Search of human proteins with 9966839

Search of human proteins with 9966839

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9966839 G protein-coupled receptor 84 [Homo sapiens]
         (396 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9966839 G protein-coupled receptor 84 [Homo sapiens]               790   0.0  
gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]         102   8e-22
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                 97   2e-20
gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]            97   3e-20
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]     94   3e-19
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]     94   3e-19
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]     94   3e-19
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]     94   3e-19
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap...    91   2e-18
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]              89   7e-18
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap...    88   1e-17
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                 85   1e-16
gi|16876435 G protein-coupled receptor 101 [Homo sapiens]              83   5e-16
gi|222080095 orexin receptor 1 [Homo sapiens]                          82   6e-16
gi|222080109 orexin receptor 2 [Homo sapiens]                          82   8e-16
gi|150170722 G protein-coupled receptor 50 [Homo sapiens]              81   1e-15
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                   81   2e-15
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]                80   4e-15
gi|28875799 cholecystokinin B receptor [Homo sapiens]                  80   4e-15
gi|15150803 opsin 4 isoform 1 [Homo sapiens]                           79   7e-15
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa...    79   9e-15
gi|157364957 pancreatic polypeptide receptor 1 [Homo sapiens]          79   9e-15
gi|5453796 neuropeptide Y receptor Y5 [Homo sapiens]                   78   1e-14
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]          77   2e-14
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]                77   3e-14
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...    77   3e-14
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi...    76   6e-14
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]    75   8e-14
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]    75   8e-14
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]     75   8e-14

>gi|9966839 G protein-coupled receptor 84 [Homo sapiens]
          Length = 396

 Score =  790 bits (2041), Expect = 0.0
 Identities = 396/396 (100%), Positives = 396/396 (100%)

Query: 1   MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIA 60
           MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIA
Sbjct: 1   MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIA 60

Query: 61  NLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYL 120
           NLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYL
Sbjct: 61  NLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYL 120

Query: 121 LIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTT 180
           LIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTT
Sbjct: 121 LIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTT 180

Query: 181 ILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQE 240
           ILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQE
Sbjct: 181 ILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQE 240

Query: 241 LDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQP 300
           LDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQP
Sbjct: 241 LDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQP 300

Query: 301 IKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTW 360
           IKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTW
Sbjct: 301 IKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTW 360

Query: 361 LNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH 396
           LNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
Sbjct: 361 LNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH 396


>gi|17986270 dopamine receptor D2 isoform short [Homo sapiens]
          Length = 414

 Score =  102 bits (253), Expect = 8e-22
 Identities = 107/408 (26%), Positives = 176/408 (43%), Gaps = 41/408 (10%)

Query: 2   WNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIAN 61
           +N SD      H     Y Y A    +++AV    GNVL  +A++ +  L+T  N LI +
Sbjct: 22  FNGSDGKADRPH-----YNYYATLLTLLIAVI-VFGNVLVCMAVSREKALQTTTNYLIVS 75

Query: 62  LTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLL 121
           L +ADLL  TL+ P+ V   +   W+     C +F  L     + SIL LC I++ RY  
Sbjct: 76  LAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTA 135

Query: 122 IAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRP---- 177
           +A P L+   +S+K  V  ++S  +V V SF    P  +L  +      + I   P    
Sbjct: 136 VAMPMLYNTRYSSKRRVTVMIS--IVWVLSFTISCP--LLFGLNNADQNECIIANPAFVV 191

Query: 178 YTTIL-MGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPG 236
           Y++I+   + F++ L      Y ++ R+ KR          R +     H+    +    
Sbjct: 192 YSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTK------RSSRAFRAHLRAPLKEAAR 245

Query: 237 RFQELD-SRLASGGPSEGISSEPVSAATTQTLEGDSSEVG----------------DQIN 279
           R QEL+   L+S  P E     P+  +  Q    D S  G                 + +
Sbjct: 246 RAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDH 305

Query: 280 SKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLN 339
            K AK    ++ P    +   +K   R   S  +  K T+M   V   F + ++PF + +
Sbjct: 306 PKIAKIFEIQTMPNGKTRTS-LKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITH 364

Query: 340 ILDARVQA--PRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSIL 385
           IL+       P V++     L ++N  +NP++Y   N +FR+A+  IL
Sbjct: 365 ILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL 412


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 91/373 (24%), Positives = 161/373 (43%), Gaps = 64/373 (17%)

Query: 23  AVSWGVVVA---VTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVD 79
           A+S G+V+    +   VGN+L +L++A    LRT  N  I NL +ADLL    + PFS  
Sbjct: 45  AISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAA 104

Query: 80  TYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL 139
             +  +W  G  FC ++  +     + SIL+LC I++ RY+ + +   +P + + +  +L
Sbjct: 105 LEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAIL 164

Query: 140 ALVSTWVVG-VASFAPL--WPIYILVPVVCTCSFDRIRGRPYTTILMGI-YFVLGLSSVG 195
           AL+S WV+  V S  PL  W      P         +   P+  +   +  F + L+ + 
Sbjct: 165 ALLSVWVLSTVISIGPLLGWK----EPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVIL 220

Query: 196 IFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGIS 255
           + YC ++   KR  + L+   +++ S                 +EL  R+ S    E   
Sbjct: 221 VMYCRVYIVAKRTTKNLEAGVMKEMS---------------NSKELTLRIHSKNFHE--- 262

Query: 256 SEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFG 315
                               D ++S +AK       P +S   +  K +R          
Sbjct: 263 --------------------DTLSSTKAK----GHNPRSSIAVKLFKFSREK-------- 290

Query: 316 KVTRMCFAVFLCFALSYIPFLL---LNILDARVQAPRVVHMLAANLTWLNGCINPVLYAA 372
           K  +    V   F L ++PF +   L  L + ++ P  V  +   L + N C+NP++Y  
Sbjct: 291 KAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPC 350

Query: 373 MNRQFRQAYGSIL 385
            +++F++A+  IL
Sbjct: 351 SSKEFKRAFVRIL 363


>gi|4503385 dopamine receptor D2 isoform long [Homo sapiens]
          Length = 443

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 112/431 (25%), Positives = 179/431 (41%), Gaps = 58/431 (13%)

Query: 2   WNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIAN 61
           +N SD      H     Y Y A    +++AV    GNVL  +A++ +  L+T  N LI +
Sbjct: 22  FNGSDGKADRPH-----YNYYATLLTLLIAVI-VFGNVLVCMAVSREKALQTTTNYLIVS 75

Query: 62  LTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLL 121
           L +ADLL  TL+ P+ V   +   W+     C +F  L     + SIL LC I++ RY  
Sbjct: 76  LAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTA 135

Query: 122 IAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTI 181
           +A P L+   +S+K  V  ++S  +V V SF    P  +L  +      + I   P   +
Sbjct: 136 VAMPMLYNTRYSSKRRVTVMIS--IVWVLSFTISCP--LLFGLNNADQNECIIANPAFVV 191

Query: 182 LMGI------YFVLGLSSVGIFYCLIHRQ----VKRAAQAL---------------DQYK 216
              I      + V  L  + I+  L  R+     KR+++A                +  K
Sbjct: 192 YSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMK 251

Query: 217 LRQASIHSN---HVARTDEAMPGRFQELD-SRLASGGPSEGISSEPVSAATTQTLEGDSS 272
           L    + SN    V R       R QEL+   L+S  P E     P+  +  Q    D S
Sbjct: 252 LCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPS 311

Query: 273 EVG----------------DQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGK 316
             G                 + + K AK    ++ P    +   +K   R   S  +  K
Sbjct: 312 HHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTS-LKTMSRRKLSQQKEKK 370

Query: 317 VTRMCFAVFLCFALSYIPFLLLNILDARVQA--PRVVHMLAANLTWLNGCINPVLYAAMN 374
            T+M   V   F + ++PF + +IL+       P V++     L ++N  +NP++Y   N
Sbjct: 371 ATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFN 430

Query: 375 RQFRQAYGSIL 385
            +FR+A+  IL
Sbjct: 431 IEFRKAFLKIL 441


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 86/372 (23%), Positives = 161/372 (43%), Gaps = 63/372 (16%)

Query: 23  AVSWGVVVA---VTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVD 79
           A+  GV++    + G +GN+L +L++A    L +  +  I NL +ADLL  + + PFS  
Sbjct: 26  AILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI 85

Query: 80  TYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL 139
             +  +W  G  FC ++  +     + SI+ LC+I++ RY+ +++P  +P + + +  ++
Sbjct: 86  FEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145

Query: 140 ALVSTWVVG-VASFAPLWPIYILVPVVCT-CSFDRIRGRPYTTILMGIYFVLGLSSVGIF 197
           AL+  W +  V S  PL+      P   T C  +   G    + L   Y  L L+ + + 
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY--LPLAIILVM 203

Query: 198 YCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257
           YC ++   KR ++ L                                        G+ ++
Sbjct: 204 YCRVYVVAKRESRGL--------------------------------------KSGLKTD 225

Query: 258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKV 317
                     + DS +V  +I+ K A          ASAK +     R    S  +  K 
Sbjct: 226 ----------KSDSEQVTLRIHRKNAPAGGSGM---ASAKTKTHFSVRLLKFSREK--KA 270

Query: 318 TRMCFAVFLCFALSYIPFLLLNILDA---RVQAPRVVHMLAANLTWLNGCINPVLYAAMN 374
            +    V  CF L ++PF L+  + +     +    V  +   L +LN CINP++Y   +
Sbjct: 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 375 RQFRQAYGSILK 386
           ++F++A+ ++L+
Sbjct: 331 QEFKKAFQNVLR 342


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 86/372 (23%), Positives = 161/372 (43%), Gaps = 63/372 (16%)

Query: 23  AVSWGVVVA---VTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVD 79
           A+  GV++    + G +GN+L +L++A    L +  +  I NL +ADLL  + + PFS  
Sbjct: 26  AILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI 85

Query: 80  TYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL 139
             +  +W  G  FC ++  +     + SI+ LC+I++ RY+ +++P  +P + + +  ++
Sbjct: 86  FEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145

Query: 140 ALVSTWVVG-VASFAPLWPIYILVPVVCT-CSFDRIRGRPYTTILMGIYFVLGLSSVGIF 197
           AL+  W +  V S  PL+      P   T C  +   G    + L   Y  L L+ + + 
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY--LPLAIILVM 203

Query: 198 YCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257
           YC ++   KR ++ L                                        G+ ++
Sbjct: 204 YCRVYVVAKRESRGL--------------------------------------KSGLKTD 225

Query: 258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKV 317
                     + DS +V  +I+ K A          ASAK +     R    S  +  K 
Sbjct: 226 ----------KSDSEQVTLRIHRKNAPAGGSGM---ASAKTKTHFSVRLLKFSREK--KA 270

Query: 318 TRMCFAVFLCFALSYIPFLLLNILDA---RVQAPRVVHMLAANLTWLNGCINPVLYAAMN 374
            +    V  CF L ++PF L+  + +     +    V  +   L +LN CINP++Y   +
Sbjct: 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 375 RQFRQAYGSILK 386
           ++F++A+ ++L+
Sbjct: 331 QEFKKAFQNVLR 342


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 86/372 (23%), Positives = 161/372 (43%), Gaps = 63/372 (16%)

Query: 23  AVSWGVVVA---VTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVD 79
           A+  GV++    + G +GN+L +L++A    L +  +  I NL +ADLL  + + PFS  
Sbjct: 26  AILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI 85

Query: 80  TYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL 139
             +  +W  G  FC ++  +     + SI+ LC+I++ RY+ +++P  +P + + +  ++
Sbjct: 86  FEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145

Query: 140 ALVSTWVVG-VASFAPLWPIYILVPVVCT-CSFDRIRGRPYTTILMGIYFVLGLSSVGIF 197
           AL+  W +  V S  PL+      P   T C  +   G    + L   Y  L L+ + + 
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY--LPLAIILVM 203

Query: 198 YCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257
           YC ++   KR ++ L                                        G+ ++
Sbjct: 204 YCRVYVVAKRESRGL--------------------------------------KSGLKTD 225

Query: 258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKV 317
                     + DS +V  +I+ K A          ASAK +     R    S  +  K 
Sbjct: 226 ----------KSDSEQVTLRIHRKNAPAGGSGM---ASAKTKTHFSVRLLKFSREK--KA 270

Query: 318 TRMCFAVFLCFALSYIPFLLLNILDA---RVQAPRVVHMLAANLTWLNGCINPVLYAAMN 374
            +    V  CF L ++PF L+  + +     +    V  +   L +LN CINP++Y   +
Sbjct: 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 375 RQFRQAYGSILK 386
           ++F++A+ ++L+
Sbjct: 331 QEFKKAFQNVLR 342


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 86/372 (23%), Positives = 161/372 (43%), Gaps = 63/372 (16%)

Query: 23  AVSWGVVVA---VTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVD 79
           A+  GV++    + G +GN+L +L++A    L +  +  I NL +ADLL  + + PFS  
Sbjct: 26  AILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAI 85

Query: 80  TYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVL 139
             +  +W  G  FC ++  +     + SI+ LC+I++ RY+ +++P  +P + + +  ++
Sbjct: 86  FEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLM 145

Query: 140 ALVSTWVVG-VASFAPLWPIYILVPVVCT-CSFDRIRGRPYTTILMGIYFVLGLSSVGIF 197
           AL+  W +  V S  PL+      P   T C  +   G    + L   Y  L L+ + + 
Sbjct: 146 ALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFY--LPLAIILVM 203

Query: 198 YCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257
           YC ++   KR ++ L                                        G+ ++
Sbjct: 204 YCRVYVVAKRESRGL--------------------------------------KSGLKTD 225

Query: 258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKV 317
                     + DS +V  +I+ K A          ASAK +     R    S  +  K 
Sbjct: 226 ----------KSDSEQVTLRIHRKNAPAGGSGM---ASAKTKTHFSVRLLKFSREK--KA 270

Query: 318 TRMCFAVFLCFALSYIPFLLLNILDA---RVQAPRVVHMLAANLTWLNGCINPVLYAAMN 374
            +    V  CF L ++PF L+  + +     +    V  +   L +LN CINP++Y   +
Sbjct: 271 AKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSS 330

Query: 375 RQFRQAYGSILK 386
           ++F++A+ ++L+
Sbjct: 331 QEFKKAFQNVLR 342


>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
           sapiens]
          Length = 365

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 91/367 (24%), Positives = 157/367 (42%), Gaps = 44/367 (11%)

Query: 28  VVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWR 87
           VV+    T+ N+  ++A+    KL    N LI +L + DLL   L+ P S+   +   W+
Sbjct: 30  VVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWK 89

Query: 88  TGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVV 147
            G   C V+  +     + SIL LC+IAL RY  I +   + +  +AK   L +++ W +
Sbjct: 90  LGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTI 149

Query: 148 GV-ASFAPL-WPIYILV---PVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIH 202
            +  S  PL W  +  +   P  CT   D +    Y+T  +G +++     + ++Y + H
Sbjct: 150 SIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYST--LGAFYIPLTLILILYYRIYH 207

Query: 203 RQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAA 262
                AA++L  Y+ R +S H ++            +  DS+           +   S  
Sbjct: 208 -----AAKSL--YQKRGSSRHLSN------------RSTDSQ-----------NSFASCK 237

Query: 263 TTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCF 322
            TQT         D          + + PP  +    P     R   SS+   K  R+  
Sbjct: 238 LTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHP---GERQQISSTRERKAARILG 294

Query: 323 AVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWL---NGCINPVLYAAMNRQFRQ 379
            +   F LS++PF +  ++   +    V   +A  LTWL   N  INP+LY + N  F+ 
Sbjct: 295 LILGAFILSWLPFFIKELI-VGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKL 353

Query: 380 AYGSILK 386
           A+  +++
Sbjct: 354 AFKKLIR 360


>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
          Length = 400

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 99/404 (24%), Positives = 167/404 (41%), Gaps = 35/404 (8%)

Query: 4   SSDANFSCYHESVLG------YRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNL 57
           S   N++C  E+  G      + Y A+S+  ++      GN L  +A+  +  L+T  N 
Sbjct: 8   SGHLNYTCGAENSTGASQARPHAYYALSYCALILAI-VFGNGLVCMAVLKERALQTTTNY 66

Query: 58  LIANLTLADLLYCTLLQPFSVDTYLHLH---WRTGATFCRVFGLLLFASNSVSILTLCLI 114
           L+ +L +ADLL  TL+ P+ V  YL +    W      C VF  L     + SIL LC I
Sbjct: 67  LVVSLAVADLLVATLVMPWVV--YLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAI 124

Query: 115 ALGRYLLIAHPKLFPQ---VFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFD 171
           ++ RY  +  P  +       S + + L + + WV+  A   PL   +        CS  
Sbjct: 125 SIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSIS 184

Query: 172 RIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTD 231
                 Y+++ +  Y   G++ +      +  + +R  + L +   +  S+      +T 
Sbjct: 185 NPDFVIYSSV-VSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTL 243

Query: 232 EAMPG-----RFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQM 286
              P      R+  +    A GGP  G           +  E   + +   I  K + ++
Sbjct: 244 SPDPAHLELKRYYSICQDTALGGP--GFQER---GGELKREEKTRNSLSPTIAPKLSLEV 298

Query: 287 AEKSPP--EASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDAR 344
            + S      S K  P++  R  P       K T+M   V   F + ++PF L ++L+  
Sbjct: 299 RKLSNGRLSTSLKLGPLQ-PRGVPLREK---KATQMVAIVLGAFIVCWLPFFLTHVLNTH 354

Query: 345 VQAPRVVHMLAANLTWL---NGCINPVLYAAMNRQFRQAYGSIL 385
            Q   V   L +  TWL   N  +NPV+Y   N +FR+A+  IL
Sbjct: 355 CQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398


>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
           sapiens]
          Length = 458

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 87/393 (22%), Positives = 170/393 (43%), Gaps = 52/393 (13%)

Query: 1   MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIA 60
           ++N+SD     + + V  +  +++   V++ +    GN+L ++A++++ KL    N  + 
Sbjct: 37  IFNTSDGGRFKFPDGVQNWPALSI---VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLM 93

Query: 61  NLTLADLLYCTLLQPFSVDTYLHLH-WRTGATFCRVFGLLLFASNSVSILTLCLIALGRY 119
           +L +AD+L   L+ P S+   L+ + W      C V+  L    ++ SI+ LC I+L RY
Sbjct: 94  SLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRY 153

Query: 120 LLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYT 179
           + I +P    +  S    ++ +   W + +    P       +PV+     +++     T
Sbjct: 154 VAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVP-------IPVIGLRDEEKVFVNNTT 206

Query: 180 TILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQ 239
            +L    FVL  S V  F   I   +      L  Y LR+ ++   H   T+E       
Sbjct: 207 CVLNDPNFVLIGSFVAFF---IPLTIMVITYCLTIYVLRRQALMLLH-GHTEE------- 255

Query: 240 ELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQ 299
                        G+S + +      T E ++S   +Q  + R ++  E+ P        
Sbjct: 256 -----------PPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRP-------- 296

Query: 300 PIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQA---PRVVHMLAA 356
             +G  +A ++  +  KV  + F VFL   + + PF + NIL    +     +++  L  
Sbjct: 297 --RGTMQAINNERKASKVLGIVFFVFL---IMWCPFFITNILSVLCEKSCNQKLMEKLLN 351

Query: 357 NLTWLN---GCINPVLYAAMNRQFRQAYGSILK 386
              W+      INP++Y   N+ +R+A+ + L+
Sbjct: 352 VFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLR 384


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 88/372 (23%), Positives = 148/372 (39%), Gaps = 59/372 (15%)

Query: 24  VSWGVVVA---VTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDT 80
           V  GV +A   +    GN+L +L++A    L+T  N  I NL +ADLL    + PFS   
Sbjct: 97  VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156

Query: 81  YLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLA 140
            +   W  G  FC V+  +     + SIL+LC I++ RY+ + H   +P + + +     
Sbjct: 157 EVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAI 216

Query: 141 LVSTWVVG-VASFAPL--WPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIF 197
           L   WVV  V S  PL  W   +  P    C      G  Y        F L ++ + + 
Sbjct: 217 LALLWVVALVVSVGPLLGWKEPV-PPDERFCGITEEAG--YAVFSSVCSFYLPMAVIVVM 273

Query: 198 YCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSE 257
           YC ++   +   ++L+    R+                G+  E+  R+   G + G    
Sbjct: 274 YCRVYVVARSTTRSLEAGVKRER---------------GKASEVVLRIHCRGAATGADG- 317

Query: 258 PVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKV 317
                      G  S  G    S  + ++ + S  + +AK   I                
Sbjct: 318 ---------AHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAI---------------- 352

Query: 318 TRMCFAVFLCFALSYIPF---LLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMN 374
                 V   F L + PF   L L  L  +++    V  +   L + N C+NP++Y   +
Sbjct: 353 ------VVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSS 406

Query: 375 RQFRQAYGSILK 386
           R+F++A+  +L+
Sbjct: 407 REFKRAFLRLLR 418


>gi|16876435 G protein-coupled receptor 101 [Homo sapiens]
          Length = 508

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 96/437 (21%), Positives = 165/437 (37%), Gaps = 81/437 (18%)

Query: 28  VVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWR 87
           V+      VGN++  L L  +P+L    N  I NL + DLL  +L+ P+ V T + L W 
Sbjct: 39  VIFLAASFVGNIVLALVLQRKPQLLQVTNRFIFNLLVTDLLQISLVAPWVVATSVPLFWP 98

Query: 88  TGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVV 147
             + FC     L       S+ T+ ++++ RYL I HP  +P   + +   L L  TW+V
Sbjct: 99  LNSHFCTALVSLTHLFAFASVNTIVVVSVDRYLSIIHPLSYPSKMTQRRGYLLLYGTWIV 158

Query: 148 GVASFAPLWPIYILVPVV-----CTCSFDRIRGRPYTTILMGIYFVLGL----SSVGIFY 198
            +    P  P+Y             CS        YT + +  + V+ L    +   + +
Sbjct: 159 AILQSTP--PLYGWGQAAFDERNALCSMIWGASPSYTILSVVSFIVIPLIVMIACYSVVF 216

Query: 199 CLIHRQ------VKR-----------------AAQALDQYKLRQASIHSNHVARTDEAMP 235
           C   RQ      VKR                  A+  ++++  ++     H     +A  
Sbjct: 217 CAARRQHALLYNVKRHSLEVRVKDCVENEDEEGAEKKEEFQ-DESEFRRQHEGEV-KAKE 274

Query: 236 GRFQELDSRLASGGPSEGISSEPVSA------------ATTQTLEGDSSEVGDQINSKRA 283
           GR +  D  L +   S G S   V A            A+  ++EG       + NS +A
Sbjct: 275 GRMEAKDGSLKAKEGSTGTSESSVEARGSEEVRESSTVASDGSMEGKEGSTKVEENSMKA 334

Query: 284 KQ------------------------MAEKSPPEASAKAQPIKGARRAPDSSSEFG---- 315
            +                           +   EA    + +  +RR  +S+        
Sbjct: 335 DKGRTEVNQCSIDLGEDDMEFGEDDINFSEDDVEAVNIPESLPPSRRNSNSNPPLPRCYQ 394

Query: 316 -KVTRMCFAVFLCFALSYIPFLLLNIL----DARVQAPRVVHMLAANLTWLNGCINPVLY 370
            K  ++ F +   + LS  P+  L +L    D   Q P+ V  +   L +L  CI+P +Y
Sbjct: 395 CKAAKVIFIIIFSYVLSLGPYCFLAVLAVWVDVETQVPQWVITIIIWLFFLQCCIHPYVY 454

Query: 371 AAMNRQFRQAYGSILKR 387
             M++  ++    +LK+
Sbjct: 455 GYMHKTIKKEIQDMLKK 471


>gi|222080095 orexin receptor 1 [Homo sapiens]
          Length = 425

 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 96/384 (25%), Positives = 149/384 (38%), Gaps = 80/384 (20%)

Query: 19  YRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSV 78
           Y +V ++  V V V   VGN L  LA+     +RT  N  I NL+LAD+L   +  P S+
Sbjct: 45  YEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASL 104

Query: 79  DTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVF-SAKGI 137
              +   W  G   C+V   L   S SV++LTL  IAL R+  I HP LF      A+G 
Sbjct: 105 LVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGS 164

Query: 138 VLALVSTWVVGVASFAPLWPIYILVPVV----------CTCSFDRIRGRPYTTILMGIYF 187
           +L +   W V +A   P   +     V+            C  +R     Y  I    +F
Sbjct: 165 ILGI---WAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCD-ERWADDLYPKIYHSCFF 220

Query: 188 VLG-LSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLA 246
           ++  L+ +G+   + + Q+ R              +    +  T  A+   ++    +L 
Sbjct: 221 IVTYLAPLGLM-AMAYFQIFR-------------KLWGRQIPGTTSALVRNWKRPSDQL- 265

Query: 247 SGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARR 306
            G   +G+S EP   A     E               KQM                 ARR
Sbjct: 266 -GDLEQGLSGEPQPRARAFLAE--------------VKQMR----------------ARR 294

Query: 307 APDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILD---------ARVQAPRVVHMLAAN 357
                    K  +M   V L FAL Y+P  +LN+L          +  +A       +  
Sbjct: 295 ---------KTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHW 345

Query: 358 LTWLNGCINPVLYAAMNRQFRQAY 381
           L + N   NP++Y  ++ +FR+ +
Sbjct: 346 LVYANSAANPIIYNFLSGKFREQF 369


>gi|222080109 orexin receptor 2 [Homo sapiens]
          Length = 444

 Score = 82.0 bits (201), Expect = 8e-16
 Identities = 87/381 (22%), Positives = 144/381 (37%), Gaps = 76/381 (19%)

Query: 19  YRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSV 78
           Y +V ++  ++V V   +GNVL  +A+     +RT  N  I NL+LAD+L      P ++
Sbjct: 53  YEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATL 112

Query: 79  DTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIV 138
              +   W  G + C+V   L   S SVS+LTL  IAL R+  I HP +F    +AK   
Sbjct: 113 VVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRAR 170

Query: 139 LALVSTWVVGVASFAP---------LWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVL 189
            ++V  W+V      P         ++P       + T   +R  G  Y  +    +F++
Sbjct: 171 NSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLV 230

Query: 190 GLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGG 249
              +      L + Q+ R              +    +  T   +  +++ L       G
Sbjct: 231 TYMAPLCLMVLAYLQIFR-------------KLWCRQIPGTSSVVQRKWKPLQPVSQPRG 277

Query: 250 PSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPD 309
           P +   S               S V  +I   RA++                        
Sbjct: 278 PGQPTKSR-------------MSAVAAEIKQIRARR------------------------ 300

Query: 310 SSSEFGKVTRMCFAVFLCFALSYIPFLLLNILD------ARVQAPRVVHMLAANLTWL-- 361
                 K  RM   V L FA+ Y+P  +LN+L       A  +    V+       WL  
Sbjct: 301 ------KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVY 354

Query: 362 -NGCINPVLYAAMNRQFRQAY 381
            N   NP++Y  ++ +FR+ +
Sbjct: 355 ANSAANPIIYNFLSGKFREEF 375


>gi|150170722 G protein-coupled receptor 50 [Homo sapiens]
          Length = 617

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 53/189 (28%), Positives = 86/189 (45%), Gaps = 2/189 (1%)

Query: 28  VVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWR 87
           V+  V   +GN + +LA+    KLR   N+ + +L++AD+L      P  +       W 
Sbjct: 36  VITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWD 95

Query: 88  TGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVV 147
                C++ G +   S   SI  +  IA+ RY  I H   + ++FS +   + LV TW++
Sbjct: 96  LSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIM 155

Query: 148 GVASFAPLWPIYILV--PVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQV 205
            V +  P   I  +   P   TC F+ +    +T  ++ I+FVL L  VG  Y  I  +V
Sbjct: 156 TVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKV 215

Query: 206 KRAAQALDQ 214
             A     Q
Sbjct: 216 LAARDPAGQ 224



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 21/69 (30%), Positives = 37/69 (53%), Gaps = 6/69 (8%)

Query: 322 FAVFLCFALSYIPFLLLNILDA------RVQAPRVVHMLAANLTWLNGCINPVLYAAMNR 375
           F +FL FA+ + P  +L +L A        + P  +++ A  + + N C+N V+Y  +N 
Sbjct: 240 FVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNE 299

Query: 376 QFRQAYGSI 384
            FR+ Y +I
Sbjct: 300 NFRREYWTI 308


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 92/375 (24%), Positives = 148/375 (39%), Gaps = 62/375 (16%)

Query: 37  GNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVF 96
           GNVL ++A+A  P+L+T  NL I +L  ADL+   L+ PF     +   W  G+ FC ++
Sbjct: 75  GNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELW 134

Query: 97  GLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFS---AKGIVLALVSTWVV-GVASF 152
             +     + SI TLC+IAL RYL I  P  +  + +   A+G+V    + W +  + SF
Sbjct: 135 TSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV---CTVWAISALVSF 191

Query: 153 APL----WPIYILVPVVC-----TCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHR 203
            P+    W         C      C F  +  R Y      + F + L  +   Y  + R
Sbjct: 192 LPILMHWWRAESDEARRCYNDPKCCDF--VTNRAYAIASSVVSFYVPLCIMAFVYLRVFR 249

Query: 204 QVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAAT 263
           + ++  + +D  + R         AR     P       S + +  P  G    P +AA 
Sbjct: 250 EAQKQVKKIDSCERR----FLGGPARPPSPSP-------SPVPAPAPPPG-PPRPAAAAA 297

Query: 264 TQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFA 323
           T  L           N +  K+   +       KA    G                    
Sbjct: 298 TAPL----------ANGRAGKRRPSRLVALREQKALKTLG-------------------I 328

Query: 324 VFLCFALSYIPFLLLNILDA--RVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAY 381
           +   F L ++PF L N++ A  R   P  + +    L + N   NP++Y   +  FR+A+
Sbjct: 329 IMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIY-CRSPDFRKAF 387

Query: 382 GSILKRGPRSFHRLH 396
             +L    R+  R H
Sbjct: 388 QGLLCCARRAARRRH 402


>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
          Length = 408

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 96/378 (25%), Positives = 152/378 (40%), Gaps = 77/378 (20%)

Query: 28  VVVAVTGTVG-NVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHW 86
           + +AV  TVG N+L ++A+A  P+L+T  N+ + +L  ADL+   L+ P +    L  HW
Sbjct: 44  LALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHW 103

Query: 87  RTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWV 146
             GAT C ++  +     + SI TLC +A+ RYL + +P  +  + + +    A+V  WV
Sbjct: 104 PLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWV 163

Query: 147 VGVA-SFAPLWPIYILVPVVC----------TCSFDRIRGRPYTTILMGIYFVLGLSSVG 195
           V  A SFAP+   +  V               C+F      PY  +   + F L L  + 
Sbjct: 164 VSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAF--ASNMPYVLLSSSVSFYLPLLVML 221

Query: 196 IFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGIS 255
             Y  +         A  Q +L +  +             GRF   +S  A   PS  ++
Sbjct: 222 FVYARVF------VVATRQLRLLRGEL-------------GRFPPEESPPA---PSRSLA 259

Query: 256 SEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFG 315
             PV                              +PPE       +    R P       
Sbjct: 260 PAPVGTC---------------------------APPEG------VPACGRRPARLLPLR 286

Query: 316 KVTRMCF--AVFLCFALSYIPFLLLNILDARVQAPRVV---HMLAAN-LTWLNGCINPVL 369
           +   +C    +   F L ++PF L N+L A +  P +V     LA N L + N   NP++
Sbjct: 287 EHRALCTLGLIMGTFTLCWLPFFLANVLRA-LGGPSLVPGPAFLALNWLGYANSAFNPLI 345

Query: 370 YAAMNRQFRQAYGSILKR 387
           Y   +  FR A+  +L R
Sbjct: 346 Y-CRSPDFRSAFRRLLCR 362


>gi|28875799 cholecystokinin B receptor [Homo sapiens]
          Length = 447

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 93/402 (23%), Positives = 162/402 (40%), Gaps = 56/402 (13%)

Query: 3   NSSDANFSCYHESVLGYRY------VAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFN 56
           +SS  N SC    + G         + ++   V+ +    GN+L ++ L +  +LRT  N
Sbjct: 31  SSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTN 90

Query: 57  LLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIAL 116
             + +L ++DLL      PF++   L   +  G   C+    L+  S SVS L+L  IAL
Sbjct: 91  AFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIAL 150

Query: 117 GRYLLIAHPKLFPQVFSAKG-IVLALVSTWVVGVASFAPLWPIYILV----PVVCTC--- 168
            RY  I  P L  +V+  +      +V+TW++      P +P+Y +V    P V  C   
Sbjct: 151 ERYSAICRP-LQARVWQTRSHAARVIVATWLLSGLLMVP-YPVYTVVQPVGPRVLQCVHR 208

Query: 169 -SFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHV 227
               R+R      +L+ ++F+ G+  + + Y LI R++    +  D      +   S   
Sbjct: 209 WPSARVRQTWSVLLLLLLFFIPGV-VMAVAYGLISRELYLGLR-FD----GDSDSDSQSR 262

Query: 228 ARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMA 287
            R    +PG   +                             ++  VG+  +    +   
Sbjct: 263 VRNQGGLPGAVHQ-----------------------NGRCRPETGAVGEDSDGCYVQLPR 299

Query: 288 EKSPPEASAKAQPIKGARRAPDSSSEFGK--VTRMCFAVFLCFALSYIPFLLLNILDARV 345
            +   E +A   P  G+   P  +    K  V RM   + + F L ++P    N   A  
Sbjct: 300 SRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRA-F 358

Query: 346 QAPRVVHMLAAN-------LTWLNGCINPVLYAAMNRQFRQA 380
             P     L+         L++ + C+NP++Y  M+R+FRQA
Sbjct: 359 DGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQA 400


>gi|15150803 opsin 4 isoform 1 [Homo sapiens]
          Length = 478

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 55/195 (28%), Positives = 86/195 (44%), Gaps = 7/195 (3%)

Query: 28  VVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWR 87
           ++V +TG +GN+  +        LRT  N+ I NL ++D L      P    + L+  W 
Sbjct: 78  LLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWL 137

Query: 88  TGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVV 147
            G T C  +          S++TL  IAL RYL+I  P     V S +     L+  W+ 
Sbjct: 138 FGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLY 197

Query: 148 GVA-SFAPL--WPIYILVPVVCTCSFDRIRGRP----YTTILMGIYFVLGLSSVGIFYCL 200
            +A S  P   W  Y+   ++ +CS+D +   P    YT +L    F L L  +   Y  
Sbjct: 198 ALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIF 257

Query: 201 IHRQVKRAAQALDQY 215
           I R ++   +AL  +
Sbjct: 258 IFRAIRETGRALQTF 272


>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
           sapiens]
          Length = 366

 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 92/393 (23%), Positives = 171/393 (43%), Gaps = 43/393 (10%)

Query: 3   NSSDANFSCYHESVLGYR----YVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLL 58
           NSSD N +   E +L        V+++   +  +T T+ N L + A+ +  KL    N L
Sbjct: 5   NSSDQNLTS--EELLNRMPSKILVSLTLSGLALMTTTI-NSLVIAAIIVTRKLHHPANYL 61

Query: 59  IANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGR 118
           I +L + D L   L+ PFS+   +   W  G   C ++  +     + SIL L  IAL R
Sbjct: 62  ICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDR 121

Query: 119 YLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIY-----ILVPVVCTCSFDRI 173
           Y  I     + +  + K   + +   W++ V  F  + P++           C    D I
Sbjct: 122 YRAITDAVEYARKRTPKHAGIMITIVWIISV--FISMPPLFWRHQGTSRDDECIIKHDHI 179

Query: 174 RGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEA 233
               Y+T   G +++  L+ + I Y  I+R  K        Y  RQAS     +A+    
Sbjct: 180 VSTIYST--FGAFYI-PLALILILYYKIYRAAKTL------YHKRQAS----RIAK---- 222

Query: 234 MPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPE 293
                +E++ ++      +   S   S    ++L   S++  D+I+S   + +  +   E
Sbjct: 223 -----EEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDF-DKIHS-TVRSLRSEFKHE 275

Query: 294 ASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHM 353
            S + Q I G R    +++    +  +  A  +C+   ++  L++N+ D    +  + + 
Sbjct: 276 KSWRRQKISGTRERKAATT----LGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNF 331

Query: 354 LAANLTWLNGCINPVLYAAMNRQFRQAYGSILK 386
           LA  L +LN  INP++Y   N  F++A+  +++
Sbjct: 332 LAW-LGYLNSLINPLIYTIFNEDFKKAFQKLVR 363


>gi|157364957 pancreatic polypeptide receptor 1 [Homo sapiens]
          Length = 375

 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 67/231 (29%), Positives = 103/231 (44%), Gaps = 23/231 (9%)

Query: 8   NFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADL 67
           NFS + +  +      V+   +  V G +GN+  +     Q +     NLLIANL  +D 
Sbjct: 29  NFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDF 88

Query: 68  LYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKL 127
           L C L QP +    +  +W  G T C++   +   S +VSIL+L L+AL R+ LI +P  
Sbjct: 89  LMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTG 148

Query: 128 F-PQVFSAKGIVLALVSTWVVGVASFAPLWPIYILV----------------PVVCTCSF 170
           + P +  A    L +V  WV+      P     IL                  VVCT S+
Sbjct: 149 WKPSISQA---YLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESW 205

Query: 171 DRIRGRP-YTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQ--YKLR 218
                R  YTT L+   + L L  + + Y  I+R+++R  +   +  Y LR
Sbjct: 206 PLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLR 256


>gi|5453796 neuropeptide Y receptor Y5 [Homo sapiens]
          Length = 445

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 85/419 (20%), Positives = 164/419 (39%), Gaps = 38/419 (9%)

Query: 3   NSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANL 62
           NS    +  Y  SV   +Y  +     V++ G +GN+L L+AL  +   +T  N LI NL
Sbjct: 24  NSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNL 83

Query: 63  TLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLI 122
             +D+L      PF++ + L   W  G   C +   L   S  VS L L  IA+ RY +I
Sbjct: 84  AFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMI 143

Query: 123 AHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGR------ 176
            HP       +A      + + W +G A  +PL   + LV +  T     +  R      
Sbjct: 144 KHP--ISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVES 201

Query: 177 --------PYTTILMGIYFVLGLSSVGIFYCLIHRQV----KRAAQALDQYKLRQASIHS 224
                    +T  L+ + ++L L  + + +  + R +          L++ ++   ++H 
Sbjct: 202 WPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHP 261

Query: 225 NHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAK 284
           +  +     + G  +   S +          +  V  A  +  + + S +  +       
Sbjct: 262 SKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRS 321

Query: 285 QMAEKS------------PPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSY 332
           Q++  S             PE ++    ++  R           V      + L FA+S+
Sbjct: 322 QLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSW 381

Query: 333 IPFLLLNIL----DARVQAP--RVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSIL 385
           +P  L +++    D  +     ++V+ +   L  ++ C+NP+LY  +N   +    S++
Sbjct: 382 MPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLI 440


>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
          Length = 479

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 92/449 (20%), Positives = 167/449 (37%), Gaps = 89/449 (19%)

Query: 20  RYVAVSWGVVVAVTGT------VGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLL 73
           RY  V    +  VTG+      VGN+L +L++ +  +L+T  N  + +L  ADL+    +
Sbjct: 26  RYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLI----I 81

Query: 74  QPFSVDTY----LHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFP 129
             FS++ Y    +  +W  GA  C ++  L +  ++ S++ L +I+  RY  +  P  +P
Sbjct: 82  GAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYP 141

Query: 130 QVFSAKGIVLALVSTWVVGVASFAP---LWPIYILVPVV----CTCSFDRIRGRPYTTIL 182
              + K   L + + WV+    +AP    W   +    V    C   F       + T +
Sbjct: 142 ARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAI 201

Query: 183 MGIYFVLGLSSVGIFYCLI---HRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQ 239
              Y  + + +V   +  +    R  K   +   + K +  +   + + +     P   +
Sbjct: 202 AAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGE 261

Query: 240 ELDSRLASG----GPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEAS 295
                L +G     P   +   P   A   T    SS  G    + + +   E S  EA+
Sbjct: 262 AAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSS--GSATQNTKERPATELSTTEAT 319

Query: 296 AKAQPI---------------------------------------KGARRAPDSSSEFG- 315
             A P                                         G R A + + +F  
Sbjct: 320 TPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFAS 379

Query: 316 -----------------KVTRMCFAVFLCFALSYIPFLLLNILDARVQA--PRVVHMLAA 356
                            KVTR  FA+ L F L++ P+ ++ +++   Q+  P  V  +  
Sbjct: 380 IARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGY 439

Query: 357 NLTWLNGCINPVLYAAMNRQFRQAYGSIL 385
            L ++N  INP  YA  N  F++ +  +L
Sbjct: 440 WLCYVNSTINPACYALCNATFKKTFRHLL 468


>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
          Length = 462

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 95/405 (23%), Positives = 151/405 (37%), Gaps = 47/405 (11%)

Query: 27  GVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHW 86
           G ++  T  VGNVL ++A+     LR   NL + +L  AD+L  TL+ PFS+   L  +W
Sbjct: 59  GFLIVFT-VVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYW 117

Query: 87  RTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWV 146
             G  +C V+  L     + SI+ LC I+L RY  +     +    + + +   +V+ W+
Sbjct: 118 YFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWL 177

Query: 147 V-GVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTI--LMGIYFVLGLSSVGIFYCLIHR 203
           +  V SF PL  +Y   P         +    +  +   +G +F   L  +G+ Y  I+R
Sbjct: 178 ISAVISFPPLVSLY-RQPDGAAYPQCGLNDETWYILSSCIGSFFAPCL-IMGLVYARIYR 235

Query: 204 QVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAAT 263
             K   + L +   ++A +  +  + T E   G             P   +  +  SAA 
Sbjct: 236 VAKLRTRTLSE---KRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAA 292

Query: 264 TQTLE------------GDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSS 311
            +               G     G           AE     AS    P     RA   S
Sbjct: 293 ERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRS 352

Query: 312 SEF----------------------GKVTRMCFAVFLCFALSYIPFL----LLNILDARV 345
            EF                       + T +   V   F L + PF     L  I     
Sbjct: 353 VEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREAC 412

Query: 346 QAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPR 390
           Q P  +      + + N  +NPV+Y   N+ FR+++  IL R  R
Sbjct: 413 QVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRR 457


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 93/399 (23%), Positives = 160/399 (40%), Gaps = 39/399 (9%)

Query: 18  GYRYVAVSWGVVVAVT-------GTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYC 70
           G   V VS+ V+ ++          +GN   + A+A++  L+   N LI +L + DL+  
Sbjct: 27  GISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVS 86

Query: 71  TLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQ 130
            L+ P +    +   W  G   C +F  L     + SIL LC IAL RY  I  P  +  
Sbjct: 87  VLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN 146

Query: 131 VFSAKGIVLALVSTWVVG-VASFAPL--W--PIYILVPVVCTCSFDRIRGRPYTTILMGI 185
             + +     +  TW++G + S  P+  W  P     P  CT S D      YT     I
Sbjct: 147 KRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKD----HGYT-----I 197

Query: 186 YFVLGLSSVGIFYCLI-HRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSR 244
           Y   G   + +   L+ + ++ RAA+   +  +++               P   + ++  
Sbjct: 198 YSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGE 257

Query: 245 LASGGPSEGISSEPVSA--ATTQTLEGDSS------EVGDQINSKRAKQMAEKSPPEASA 296
             S     G+ S+   A  A     +GD        EV    NSK    +  ++ P   A
Sbjct: 258 SGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCA 317

Query: 297 KAQPIKGARRAPDSSSEFG-----KVTRMCFAVFLCFALSYIPF----LLLNILDARVQA 347
            A   +   R  ++  +       K  +    +   F L ++PF    L+L   ++    
Sbjct: 318 PASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHM 377

Query: 348 PRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILK 386
           P ++  +   L + N  +NPV+YA  N+ F+ A+  I+K
Sbjct: 378 PTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIK 416


>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
           sapiens]
          Length = 440

 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 88/377 (23%), Positives = 150/377 (39%), Gaps = 75/377 (19%)

Query: 18  GYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFS 77
           G  +VA +  VV+A+T    ++L  L +  QP LR   N  + +L  +DL+   ++ P +
Sbjct: 25  GSGWVAAALCVVIALTAAANSLLIAL-ICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPA 83

Query: 78  VDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFP-QVFSAKG 136
           +   L+  W      C ++        S SIL LCLI+L RYLLI  P  +  ++   + 
Sbjct: 84  MLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRA 143

Query: 137 IVLALVSTWVVGVASFAPL---WPI--YILVPVVCTCSFDRIRGRPYTTILMGIYFVLGL 191
           + L L +  +  +ASF PL   W    +   PV   C    +   P+  +  G+ F L  
Sbjct: 144 LALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRL--LASLPFVLVASGLTFFLPS 201

Query: 192 SSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPS 251
            ++   YC I    ++ A       ++ AS+ +   ++  E +               P 
Sbjct: 202 GAICFTYCRILLAARKQA-------VQVASLTTGMASQASETLQ----------VPRTPR 244

Query: 252 EGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSS 311
            G+ S                                     A ++    K +R+A  +S
Sbjct: 245 PGVES-------------------------------------ADSRRLATKHSRKALKAS 267

Query: 312 SEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGC---INPV 368
              G +  M       F ++++PF + NI+ A      +   L   LTWL  C   +NP+
Sbjct: 268 LTLGILLGM-------FFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPI 318

Query: 369 LYAAMNRQFRQAYGSIL 385
           +Y    R F++A G  L
Sbjct: 319 IYPLFMRDFKRALGRFL 335


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 97/406 (23%), Positives = 157/406 (38%), Gaps = 70/406 (17%)

Query: 2   WNSSDANFSCYHESVLGYRYVAVSWGVV---VAVTGTVGNVLTLLALAIQPKLRTRFNLL 58
           W++   N S   E +   R   V  G +   + +    GN L ++++    KLR   N L
Sbjct: 60  WDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYL 119

Query: 59  IANLTLADLLYCTLLQPF-SVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALG 117
           I +L LADL     + PF SV   +   W  G  FC VF  +     + SI+TLC+I++ 
Sbjct: 120 IVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID 179

Query: 118 RYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVA-SFAPL--WPIYILVPVVCTCSFDRIR 174
           RYL I  P  +P   + K +   ++S W++  + +  PL  W   +    VC  S D   
Sbjct: 180 RYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF-- 237

Query: 175 GRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAM 234
              YT     + F + +S +   Y  I++  +++           A+ H           
Sbjct: 238 --GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKS-----------AAKHK---------F 275

Query: 235 PGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEA 294
           PG F  +               EP S      +     EV +  N  R  +   K+    
Sbjct: 276 PG-FPRV---------------EPDSVIALNGIVKLQKEVEECANLSRLLKHERKN---- 315

Query: 295 SAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQA------P 348
                 I   +R   +++  G +          F + ++PF LL+     +        P
Sbjct: 316 ------ISIFKREQKAATTLGIIVG-------AFTVCWLPFFLLSTARPFICGTSCSCIP 362

Query: 349 RVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHR 394
             V      L + N  INP +YA  NR  R  Y S+L+   R+ +R
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 97/406 (23%), Positives = 157/406 (38%), Gaps = 70/406 (17%)

Query: 2   WNSSDANFSCYHESVLGYRYVAVSWGVV---VAVTGTVGNVLTLLALAIQPKLRTRFNLL 58
           W++   N S   E +   R   V  G +   + +    GN L ++++    KLR   N L
Sbjct: 60  WDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYL 119

Query: 59  IANLTLADLLYCTLLQPF-SVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALG 117
           I +L LADL     + PF SV   +   W  G  FC VF  +     + SI+TLC+I++ 
Sbjct: 120 IVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID 179

Query: 118 RYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVA-SFAPL--WPIYILVPVVCTCSFDRIR 174
           RYL I  P  +P   + K +   ++S W++  + +  PL  W   +    VC  S D   
Sbjct: 180 RYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF-- 237

Query: 175 GRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAM 234
              YT     + F + +S +   Y  I++  +++           A+ H           
Sbjct: 238 --GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKS-----------AAKHK---------F 275

Query: 235 PGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEA 294
           PG F  +               EP S      +     EV +  N  R  +   K+    
Sbjct: 276 PG-FPRV---------------EPDSVIALNGIVKLQKEVEECANLSRLLKHERKN---- 315

Query: 295 SAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQA------P 348
                 I   +R   +++  G +          F + ++PF LL+     +        P
Sbjct: 316 ------ISIFKREQKAATTLGIIVG-------AFTVCWLPFFLLSTARPFICGTSCSCIP 362

Query: 349 RVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHR 394
             V      L + N  INP +YA  NR  R  Y S+L+   R+ +R
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 97/406 (23%), Positives = 157/406 (38%), Gaps = 70/406 (17%)

Query: 2   WNSSDANFSCYHESVLGYRYVAVSWGVV---VAVTGTVGNVLTLLALAIQPKLRTRFNLL 58
           W++   N S   E +   R   V  G +   + +    GN L ++++    KLR   N L
Sbjct: 60  WDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYL 119

Query: 59  IANLTLADLLYCTLLQPF-SVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALG 117
           I +L LADL     + PF SV   +   W  G  FC VF  +     + SI+TLC+I++ 
Sbjct: 120 IVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID 179

Query: 118 RYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVA-SFAPL--WPIYILVPVVCTCSFDRIR 174
           RYL I  P  +P   + K +   ++S W++  + +  PL  W   +    VC  S D   
Sbjct: 180 RYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF-- 237

Query: 175 GRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAM 234
              YT     + F + +S +   Y  I++  +++           A+ H           
Sbjct: 238 --GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKS-----------AAKHK---------F 275

Query: 235 PGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEA 294
           PG F  +               EP S      +     EV +  N  R  +   K+    
Sbjct: 276 PG-FPRV---------------EPDSVIALNGIVKLQKEVEECANLSRLLKHERKN---- 315

Query: 295 SAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQA------P 348
                 I   +R   +++  G +          F + ++PF LL+     +        P
Sbjct: 316 ------ISIFKREQKAATTLGIIVG-------AFTVCWLPFFLLSTARPFICGTSCSCIP 362

Query: 349 RVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHR 394
             V      L + N  INP +YA  NR  R  Y S+L+   R+ +R
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINR 408


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.137    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,668,180
Number of Sequences: 37866
Number of extensions: 536948
Number of successful extensions: 3861
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 408
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 2717
Number of HSP's gapped (non-prelim): 1129
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.