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Search of human proteins with 94966757
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
(525 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94966757 protein disulfide isomerase A2 [Homo sapiens] 1057 0.0
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s... 468 e-132
gi|28372543 protein disulfide isomerase-like, testis expressed [... 253 3e-67
gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 220 3e-57
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 206 6e-53
gi|22748703 endoplasmic reticulum protein 27 kDa [Homo sapiens] 103 3e-22
gi|5803121 protein disulfide isomerase A5 [Homo sapiens] 86 6e-17
gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ... 80 6e-15
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap... 80 6e-15
gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 79 8e-15
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul... 70 5e-12
gi|38505222 thioredoxin domain containing 10 [Homo sapiens] 69 1e-11
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s... 64 3e-10
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap... 56 9e-08
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap... 56 9e-08
gi|21361403 thioredoxin 2 precursor [Homo sapiens] 54 5e-07
gi|151101292 thioredoxin domain containing 1 [Homo sapiens] 54 5e-07
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens] 51 3e-06
gi|95113651 glutaredoxin 3 [Homo sapiens] 44 4e-04
gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 43 6e-04
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 41 0.003
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 41 0.003
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 41 0.003
gi|50592994 thioredoxin [Homo sapiens] 40 0.005
gi|7705696 thioredoxin domain containing 12 [Homo sapiens] 38 0.026
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa... 37 0.034
gi|224493723 hypothetical protein LOC100130311 [Homo sapiens] 33 0.64
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi... 33 0.64
gi|94421469 disulfide isomerase [Homo sapiens] 33 0.64
gi|29893564 microspherule protein 1 isoform 1 [Homo sapiens] 32 1.1
>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
Length = 525
Score = 1057 bits (2733), Expect = 0.0
Identities = 525/525 (100%), Positives = 525/525 (100%)
Query: 1 MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHP 60
MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHP
Sbjct: 1 MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHP 60
Query: 61 ALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTL 120
ALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTL
Sbjct: 61 ALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTL 120
Query: 121 KFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQ 180
KFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQ
Sbjct: 121 KFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQ 180
Query: 181 DLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEEL 240
DLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEEL
Sbjct: 181 DLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEEL 240
Query: 241 GLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEA 300
GLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEA
Sbjct: 241 GLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEA 300
Query: 301 APRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASI 360
APRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASI
Sbjct: 301 APRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASI 360
Query: 361 TAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTH 420
TAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTH
Sbjct: 361 TAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTH 420
Query: 421 CKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKS 480
CKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKS
Sbjct: 421 CKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKS 480
Query: 481 TRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL 525
TRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL
Sbjct: 481 TRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL 525
>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
sapiens]
Length = 508
Score = 468 bits (1204), Expect = e-132
Identities = 234/468 (50%), Positives = 319/468 (68%), Gaps = 15/468 (3%)
Query: 32 EPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAE 91
+ PEEE D +LVL + AL H LLVEFYAPWCGHC+ALAPEY+KAA L AE
Sbjct: 18 DAPEEE----DHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAE 73
Query: 92 SMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRV 151
+ LAKVD + +LA+++GV YPT+KFFRNG+ P+EYT R+A+ I WL++R
Sbjct: 74 GSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRT 133
Query: 152 GPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLF 211
GP+A L D AAA++L+ ++ VIGFF+D++ + FL A+ D+ FG+T +F
Sbjct: 134 GPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVF 193
Query: 212 QQFGLTKDTVVLFKKFDEGRADFP--VDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAK 269
++ L KD VVLFKKFDEGR +F V +E LD F+ + + LV EF QT+ K
Sbjct: 194 SKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLD------FIKHNQLPLVIEFTEQTAPK 247
Query: 270 IFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVA-ADNEHVLQYFGL 328
IF I H+LLF+ ++++ + L+ F AA F+G++LF+ +D DN+ +L++FGL
Sbjct: 248 IFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGL 307
Query: 329 KAEAAPTLRLVNLETTK-KYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQ 387
K E P +RL+ LE KY P + +TA IT FCH L G++KP+L+SQE+P DWD+
Sbjct: 308 KKEECPAVRLITLEEEMTKYKP-ESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDK 366
Query: 388 RPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELD 447
+PVK LVGKNFE VAFDE KNVFV+FYAPWC HCK++AP W+ L E Y+DHE+I+IA++D
Sbjct: 367 QPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMD 426
Query: 448 ATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGG 495
+TANE++A VH FPTLK+FPA R VI+Y R L+ F KFL++GG
Sbjct: 427 STANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGG 474
>gi|28372543 protein disulfide isomerase-like, testis expressed
[Homo sapiens]
Length = 584
Score = 253 bits (646), Expect = 3e-67
Identities = 148/457 (32%), Positives = 244/457 (53%), Gaps = 5/457 (1%)
Query: 38 IPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTL 97
I +E +LVL+ L L + L+V F+ P + LA E KA ++ +
Sbjct: 39 ILEERSLLVLTPAGLTQMLNQTRFLMVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGF 98
Query: 98 AKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMR 157
KVD ++EL +EFG+T+ P LK F GNR+ P G ++ + WLRR++ A
Sbjct: 99 GKVDITIEKELQQEFGITKAPELKLFFEGNRSEPISCKGVVESAALVVWLRRQISQKAFL 158
Query: 158 LEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLT 217
+ R LV++GFFQDL++E F + +D ++TFG+ + +F +T
Sbjct: 159 FNSSEQVAEFVISRPLVIVGFFQDLEEEVAELFYDVIKDFPELTFGVITIGNVIGRFHVT 218
Query: 218 KDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILN 277
D+V++FKK +++ +L+R + H V E+N++ I I++
Sbjct: 219 LDSVLVFKKGKIVNRQKLINDSTNKQ--ELNRVIKQHLTDFVIEYNTENKDLISELHIMS 276
Query: 278 HLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAAD-NEHVLQYFGLKAEAAPTL 336
H+LLFV+++ ++ ++ + A+ F+ ++LF++VD N V +YF + P++
Sbjct: 277 HMLLFVSKSSESYGIIIQHYKLASKEFQNKILFILVDADEPRNGRVFKYFRVTEVDIPSV 336
Query: 337 RLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGK 396
+++NL + +Y + +T S+ F + L+ + S+EIP WDQ VK LVGK
Sbjct: 337 QILNLSSDARYK-MPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWDQGLVKQLVGK 395
Query: 397 NFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAF 456
NF V FD+ K+VFV FYAPW CK + P E L KYQ+H IIIA++D TAN++
Sbjct: 396 NFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTANDIQLM 455
Query: 457 AVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDN 493
+ +P + FP+G + V+ YK L+ FS FL++
Sbjct: 456 YLDRYPFFRLFPSGSQQAVL-YKGEHTLKGFSDFLES 491
>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
Length = 645
Score = 220 bits (560), Expect = 3e-57
Identities = 150/490 (30%), Positives = 251/490 (51%), Gaps = 33/490 (6%)
Query: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEY 81
QE+ E + P + LVL++ + + +LVEFYAPWCGHC+ LAPEY
Sbjct: 157 QEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEY 216
Query: 82 SKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAE 141
KAA L+ S + LAKVD A+ +LA+ F V+ YPTLK FR G P +Y GPR+
Sbjct: 217 EKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKG---RPYDYNGPREKY 273
Query: 142 GIAEWLRRRVGPSAMR-LEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDAL-D 199
GI +++ + GP + L + + L G D+++IG F+ D + A + D
Sbjct: 274 GIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLRED 333
Query: 200 MTFGLTDRPRLFQQFGLTKDTVVL-----FKKFDEGRADFPVDEELGLDLGDLSRFLVTH 254
F T + + +++ +V+ F+ E R+ +D + + F++ +
Sbjct: 334 YKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHM-MDVQGSTQDSAIKDFVLKY 392
Query: 255 SMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVD 314
++ LV AK + R L + V+ + + A +R +VL V D
Sbjct: 393 ALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSF--------DYRAATQFWRSKVLEVAKD 444
Query: 315 ------VAADNEHV---LQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCH 365
AD E ++ GL + E+ KK+A ++ + ++ F
Sbjct: 445 FPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFA-MEPEEFDSDTLREFVT 503
Query: 366 AVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMA 425
A G++KP + SQ +P + ++ PVK +VGK F+ + D K+V ++FYAPWC HCK++
Sbjct: 504 AFKKGKLKPVIKSQPVPKN-NKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLE 562
Query: 426 PAWEALAEKYQDHEDIIIAELDATANEL--DAFAVHGFPTLKYFPAGPGRKVIEYK-STR 482
P + +LA+KY+ + ++IA++DATAN++ D + V GFPT+ + P+G + ++++ R
Sbjct: 563 PVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDR 622
Query: 483 DLETFSKFLD 492
DLE SKF++
Sbjct: 623 DLEHLSKFIE 632
Score = 90.5 bits (223), Expect = 3e-18
Identities = 45/127 (35%), Positives = 69/127 (54%), Gaps = 3/127 (2%)
Query: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEY 81
+E+ EE + E+ +E+G+LVL+ + + +L+EFYAPWCGHC+ APEY
Sbjct: 42 EEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEY 101
Query: 82 SKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAE 141
K A +L + + +AK+D + LA F V+ YPT+K + G +Y G R E
Sbjct: 102 EKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAV---DYEGSRTQE 158
Query: 142 GIAEWLR 148
I +R
Sbjct: 159 EIVAKVR 165
Score = 63.2 bits (152), Expect = 6e-10
Identities = 36/103 (34%), Positives = 59/103 (57%), Gaps = 7/103 (6%)
Query: 386 DQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHE-DIIIA 444
++ V L NF+ D+ V ++FYAPWC HCK+ AP +E +A +D + I +A
Sbjct: 60 EENGVLVLNDANFDNFVADKD-TVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVA 118
Query: 445 ELDATANELDA--FAVHGFPTLKYFPAGPGRKVIEYKSTRDLE 485
++DAT+ + A F V G+PT+K G + ++Y+ +R E
Sbjct: 119 KIDATSASVLASRFDVSGYPTIKILKKG---QAVDYEGSRTQE 158
>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
Length = 505
Score = 206 bits (523), Expect = 6e-53
Identities = 144/463 (31%), Positives = 229/463 (49%), Gaps = 33/463 (7%)
Query: 62 LLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLK 121
+LVEF+APWCGHC+ LAPEY AA L +V LAKVD A ++GV+ YPTLK
Sbjct: 48 MLVEFFAPWCGHCKRLAPEYEAAATRLKG---IVPLAKVDCTANTNTCNKYGVSGYPTLK 104
Query: 122 FFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQD 181
FR+G Y GPR A+GI L+++ GP+++ L E + I +D ++GFF D
Sbjct: 105 IFRDGEEA--GAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDD 162
Query: 182 LQDEDVATFLALAQDALD-MTFGLTDRPRLFQQFGLTKDTVVLFK------KFDEGRADF 234
E + FL A + D F T+ L ++ + ++LF+ KF++ +
Sbjct: 163 SFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAY 222
Query: 235 PVDEELGLDLGDLSRFLVTHSMRL---VTEFNS---QTSAKIFAARILNHLLLFVNQTLA 288
E + G + +F+ + + +TE N Q + A +++
Sbjct: 223 ---TEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYW 279
Query: 289 AHRELLAGFGEAAPRF--RGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTK- 345
+R ++ A +F G L V H L FGL++ A + +V + T K
Sbjct: 280 RNRVMM-----VAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAG-EIPVVAIRTAKG 333
Query: 346 -KYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFD 404
K+ + ++ F +G +K YL S+ IP D PVK +V +NF+++ +
Sbjct: 334 EKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESND-GPVKVVVAENFDEIVNN 392
Query: 405 ETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDA-FAVHGFPT 463
E K+V ++FYAPWC HCK + P ++ L EK +I+IA++DATAN++ + + V GFPT
Sbjct: 393 ENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPT 452
Query: 464 LKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEP 506
+ + PA +Y+ R+L F +L P E+P
Sbjct: 453 IYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKP 495
Score = 65.9 bits (159), Expect = 9e-11
Identities = 31/92 (33%), Positives = 54/92 (58%), Gaps = 2/92 (2%)
Query: 58 EHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEY 117
E+ +L+EFYAPWCGHC+ L P+Y + L+ + +V +AK+D A ++ + V +
Sbjct: 393 ENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIV-IAKMDATA-NDVPSPYEVRGF 450
Query: 118 PTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRR 149
PT+ F + +P++Y G R+ +L+R
Sbjct: 451 PTIYFSPANKKLNPKKYEGGRELSDFISYLQR 482
Score = 57.4 bits (137), Expect = 3e-08
Identities = 30/83 (36%), Positives = 42/83 (50%), Gaps = 2/83 (2%)
Query: 390 VKTLVGKNFEQVAFDETKN--VFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELD 447
V L NFE D + V+F+APWC HCK +AP +EA A + + + +
Sbjct: 27 VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCT 86
Query: 448 ATANELDAFAVHGFPTLKYFPAG 470
A N + + V G+PTLK F G
Sbjct: 87 ANTNTCNKYGVSGYPTLKIFRDG 109
>gi|22748703 endoplasmic reticulum protein 27 kDa [Homo sapiens]
Length = 273
Score = 103 bits (258), Expect = 3e-22
Identities = 68/238 (28%), Positives = 120/238 (50%), Gaps = 6/238 (2%)
Query: 140 AEGIAEWLRRRVGPSAMR----LEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQ 195
AE AE + GP A + L D AA I ++ VIGFFQDL+ V ++ Q
Sbjct: 21 AEVAAEVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQ 80
Query: 196 DALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHS 255
++FG++ + + +T +T+ LF+ D + + ++ +D LSRF+ +S
Sbjct: 81 KFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLEDEDIESIDATKLSRFIEINS 140
Query: 256 MRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDV 315
+ +VTE+N T +F + I HLLL +N+ + E + + +AA F+G++LF++VD
Sbjct: 141 LHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDS 200
Query: 316 A-ADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQV 372
+N V+ +F LK P L + ++ + V+ + FC L+G++
Sbjct: 201 GMKENGKVISFFKLKESQLPALAIYQ-TLDDEWDTLPTAEVSVEHVQNFCDGFLSGKL 257
>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
Length = 519
Score = 86.3 bits (212), Expect = 6e-17
Identities = 48/131 (36%), Positives = 74/131 (56%), Gaps = 14/131 (10%)
Query: 32 EPPEEEIPK-----EDG-ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85
+PP+ ++P+ E G + L+ ++EH ++LV F+APWCGHC+ + PE+ KAA
Sbjct: 260 QPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAA 319
Query: 86 AVLAAES-MVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGP--RDAEG 142
L E+ LA VD + LAE F ++E+PTLK+F+NG E+Y P R +
Sbjct: 320 EALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNG-----EKYAVPVLRTKKK 374
Query: 143 IAEWLRRRVGP 153
EW++ P
Sbjct: 375 FLEWMQNPEAP 385
Score = 69.3 bits (168), Expect = 8e-12
Identities = 66/233 (28%), Positives = 105/233 (45%), Gaps = 21/233 (9%)
Query: 279 LLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDV-AADNEHVLQYFGLKAEAAPTLR 337
L++F + + ++ F +AA + RG + ++V +++ E++ + + ++ PT+
Sbjct: 174 LIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRG--FPTI- 230
Query: 338 LVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKN 397
E + D TA I + L P E P + V L ++
Sbjct: 231 -CYFEKGRFLFQYDNYGSTAEDIVEW----LKNPQPPQPQVPETPWADEGGSVYHLTDED 285
Query: 398 FEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDI--IIAELDATANE--L 453
F+Q E +V V F+APWC HCK+M P +E AE D ++A +DAT N+
Sbjct: 286 FDQFV-KEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALA 344
Query: 454 DAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEP 506
+ F + FPTLKYF G E + L T KFL+ P PP EP
Sbjct: 345 ERFHISEFPTLKYFKNG------EKYAVPVLRTKKKFLE-WMQNPEAPPPPEP 390
Score = 65.1 bits (157), Expect = 2e-10
Identities = 67/248 (27%), Positives = 113/248 (45%), Gaps = 34/248 (13%)
Query: 277 NHLLLFVNQTLAA--HRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAP 334
N L+L+ +AA H LL+ +A +GQ VD D E +K + +P
Sbjct: 48 NVLVLYSKSEVAAENHLRLLSTVAQAV---KGQGTICWVD-CGDAESRKLCKKMKVDLSP 103
Query: 335 TLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRP-VKTL 393
+ V L + DG A T + AV + +L + PP W++ P K +
Sbjct: 104 KDKKVEL-----FHYQDG-----AFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDV 153
Query: 394 VG----KNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDAT 449
V K+F ++ E K + + FYAPWC+ CK M P ++ A + + H ++A ++
Sbjct: 154 VHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGH--AVLAGMNVY 211
Query: 450 ANEL----DAFAVHGFPTLKYFPAGPGRKVIEYKS-TRDLETFSKFLDNGGVLPTEEPPE 504
++E + ++V GFPT+ YF GR + +Y + E ++L N P P+
Sbjct: 212 SSEFENIKEEYSVRGFPTICYFE--KGRFLFQYDNYGSTAEDIVEWLKN----PQPPQPQ 265
Query: 505 EPAAPFPE 512
P P+ +
Sbjct: 266 VPETPWAD 273
Score = 63.2 bits (152), Expect = 6e-10
Identities = 38/115 (33%), Positives = 58/115 (50%), Gaps = 9/115 (7%)
Query: 383 PDWD--QRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHED 440
P W+ Q V LVG NF + + K+ V FYAPWC HCK++ P + A A+ ++D
Sbjct: 390 PTWEEQQTSVLHLVGDNFRET-LKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRK 448
Query: 441 IIIAELDATANE----LDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491
I A +D ++ AV G+PT Y+ G+ +Y S R F+ ++
Sbjct: 449 IACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHY--GKFAEKYDSDRTELGFTNYI 501
Score = 59.3 bits (142), Expect = 8e-09
Identities = 38/129 (29%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 27 RSPSEEPPEEEIPKEDGILVLS--RHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKA 84
+ P P EE P ++ L + L +E LL+ FYAPWC C+ + P + KA
Sbjct: 136 KDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKA 195
Query: 85 AAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIA 144
A L +++ + V + EE+ V +PT+ +F G + G AE I
Sbjct: 196 ATQLRGHAVLAGM-NVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYG-STAEDIV 253
Query: 145 EWLRRRVGP 153
EWL+ P
Sbjct: 254 EWLKNPQPP 262
Score = 52.8 bits (125), Expect = 8e-07
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 8/131 (6%)
Query: 20 WGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAP 79
W Q A P E EE+ + +L L L++ LV FYAPWC HC+ + P
Sbjct: 378 WMQNPEAPPPPEPTWEEQ---QTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIP 434
Query: 80 EYSKAAAVLAAESMVVTLAKVD--GPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGP 137
++ A A + + A VD ++L ++ V YPT ++ G E+Y
Sbjct: 435 HFT-ATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGK--FAEKYDSD 491
Query: 138 RDAEGIAEWLR 148
R G ++R
Sbjct: 492 RTELGFTNYIR 502
>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
[Homo sapiens]
Length = 432
Score = 79.7 bits (195), Expect = 6e-15
Identities = 44/112 (39%), Positives = 64/112 (57%), Gaps = 7/112 (6%)
Query: 383 PDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEK-YQDHEDI 441
P+ D+ V L NF+ + F+KFYAPWC HCK +AP WE L++K + +
Sbjct: 317 PEADKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGV 374
Query: 442 IIAELDATA--NELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491
IAE+D TA N ++V G+PTL F G+KV E+ RDL++ +F+
Sbjct: 375 KIAEVDCTAERNICSKYSVRGYPTLLLFRG--GKKVSEHSGGRDLDSLHRFV 424
Score = 79.3 bits (194), Expect = 8e-15
Identities = 42/112 (37%), Positives = 62/112 (55%), Gaps = 15/112 (13%)
Query: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHED--IIIAELDATANE--LDAFAVHGFPTLK 465
FV F+APWC HC+ + P W L +KY ED + +A++D TA+ A V G+PTLK
Sbjct: 81 FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140
Query: 466 YFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFP--EPPA 515
F PG++ ++Y+ RD +T ++ + EEP P P EPP+
Sbjct: 141 LFK--PGQEAVKYQGPRDFQTLENWM-------LQTLNEEPVTPEPEVEPPS 183
Score = 75.9 bits (185), Expect = 9e-14
Identities = 46/123 (37%), Positives = 66/123 (53%), Gaps = 11/123 (8%)
Query: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATAN-EL-DAFAVHGFPTLKYF 467
F+KF+APWC HCK +AP WE LA + E + I ++D T + EL V G+PTL +F
Sbjct: 209 FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 268
Query: 468 PAGPGRKVIEYKSTRDLETFSKFLDN------GGVLPTEEPPEEPA-APFPEPPANSTMG 520
G+KV +YK RDLE+ +++++ G T P E P A PE + +
Sbjct: 269 --RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLA 326
Query: 521 SKE 523
E
Sbjct: 327 LTE 329
Score = 74.7 bits (182), Expect = 2e-13
Identities = 55/165 (33%), Positives = 78/165 (47%), Gaps = 13/165 (7%)
Query: 6 LPVLLLLLLR--ASCPWGQ--EQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREH-- 59
L LLLLLL WG ++ A + ++ PP + EDG S+H + H
Sbjct: 18 LTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAAD--GEDGQDPHSKHLYTADMFTHGI 75
Query: 60 --PALLVEFYAPWCGHCQALAPEYSKAA-AVLAAESMVVTLAKVDGPAQRELAEEFGVTE 116
A V F+APWCGHCQ L P ++ + E V +AKVD A ++ GV
Sbjct: 76 QSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRG 135
Query: 117 YPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDE 161
YPTLK F+ G +Y GPRD + + W+ + + + E E
Sbjct: 136 YPTLKLFKPGQEA--VKYQGPRDFQTLENWMLQTLNEEPVTPEPE 178
Score = 72.4 bits (176), Expect = 1e-12
Identities = 57/182 (31%), Positives = 86/182 (47%), Gaps = 18/182 (9%)
Query: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHT--LGLALREHPALLVEFYAPWCGHCQALAP 79
+E P EPP K+ G+ LS L +A +H ++F+APWCGHC+ALAP
Sbjct: 170 EEPVTPEPEVEPPSAPELKQ-GLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAP 225
Query: 80 EYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139
+ + A L S V + KVD EL V YPTL +FR+G + ++Y G RD
Sbjct: 226 TWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKV--DQYKGKRD 282
Query: 140 AEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD 199
E + E++ S ++ + A + + V+ + D T LAL ++ D
Sbjct: 283 LESLREYVE-----SQLQRTETGATETVTPSEAPVLAA----EPEADKGTVLALTENNFD 333
Query: 200 MT 201
T
Sbjct: 334 DT 335
Score = 69.3 bits (168), Expect = 8e-12
Identities = 39/118 (33%), Positives = 62/118 (52%), Gaps = 5/118 (4%)
Query: 28 SPSEEPPEEEIPKEDG--ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85
+PSE P P+ D +L L+ + + E ++FYAPWCGHC+ LAP + + +
Sbjct: 306 TPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS 364
Query: 86 AVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGI 143
V +A+VD A+R + ++ V YPTL FR G + E++G RD + +
Sbjct: 365 KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV--SEHSGGRDLDSL 420
>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
sapiens]
Length = 324
Score = 79.7 bits (195), Expect = 6e-15
Identities = 44/112 (39%), Positives = 64/112 (57%), Gaps = 7/112 (6%)
Query: 383 PDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEK-YQDHEDI 441
P+ D+ V L NF+ + F+KFYAPWC HCK +AP WE L++K + +
Sbjct: 209 PEADKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGV 266
Query: 442 IIAELDATA--NELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491
IAE+D TA N ++V G+PTL F G+KV E+ RDL++ +F+
Sbjct: 267 KIAEVDCTAERNICSKYSVRGYPTLLLFRG--GKKVSEHSGGRDLDSLHRFV 316
Score = 75.9 bits (185), Expect = 9e-14
Identities = 46/123 (37%), Positives = 66/123 (53%), Gaps = 11/123 (8%)
Query: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATAN-EL-DAFAVHGFPTLKYF 467
F+KF+APWC HCK +AP WE LA + E + I ++D T + EL V G+PTL +F
Sbjct: 101 FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 160
Query: 468 PAGPGRKVIEYKSTRDLETFSKFLDN------GGVLPTEEPPEEPA-APFPEPPANSTMG 520
G+KV +YK RDLE+ +++++ G T P E P A PE + +
Sbjct: 161 --RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLA 218
Query: 521 SKE 523
E
Sbjct: 219 LTE 221
Score = 72.4 bits (176), Expect = 1e-12
Identities = 57/182 (31%), Positives = 86/182 (47%), Gaps = 18/182 (9%)
Query: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHT--LGLALREHPALLVEFYAPWCGHCQALAP 79
+E P EPP K+ G+ LS L +A +H ++F+APWCGHC+ALAP
Sbjct: 62 EEPVTPEPEVEPPSAPELKQ-GLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAP 117
Query: 80 EYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139
+ + A L S V + KVD EL V YPTL +FR+G + ++Y G RD
Sbjct: 118 TWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKV--DQYKGKRD 174
Query: 140 AEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD 199
E + E++ S ++ + A + + V+ + D T LAL ++ D
Sbjct: 175 LESLREYVE-----SQLQRTETGATETVTPSEAPVLAA----EPEADKGTVLALTENNFD 225
Query: 200 MT 201
T
Sbjct: 226 DT 227
Score = 69.3 bits (168), Expect = 8e-12
Identities = 39/118 (33%), Positives = 62/118 (52%), Gaps = 5/118 (4%)
Query: 28 SPSEEPPEEEIPKEDG--ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85
+PSE P P+ D +L L+ + + E ++FYAPWCGHC+ LAP + + +
Sbjct: 198 TPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS 256
Query: 86 AVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGI 143
V +A+VD A+R + ++ V YPTL FR G + E++G RD + +
Sbjct: 257 KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV--SEHSGGRDLDSL 312
Score = 43.1 bits (100), Expect = 6e-04
Identities = 24/71 (33%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 91 ESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRR 150
E V +AKVD A ++ GV YPTLK F+ G +Y GPRD + + W+ +
Sbjct: 2 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEA--VKYQGPRDFQTLENWMLQT 59
Query: 151 VGPSAMRLEDE 161
+ + E E
Sbjct: 60 LNEEPVTPEPE 70
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 13/79 (16%)
Query: 441 IIIAELDATANE--LDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLP 498
+ +A++D TA+ A V G+PTLK F PG++ ++Y+ RD +T ++
Sbjct: 6 VYVAKVDCTAHSDVCSAQGVRGYPTLKLFK--PGQEAVKYQGPRDFQTLENWM------- 56
Query: 499 TEEPPEEPAAPFP--EPPA 515
+ EEP P P EPP+
Sbjct: 57 LQTLNEEPVTPEPEVEPPS 75
>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
Length = 440
Score = 79.3 bits (194), Expect = 8e-15
Identities = 39/83 (46%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122
LVEFYAPWCGHCQ L PE+ KAA L VV + VD L ++GV +PT+K
Sbjct: 47 LVEFYAPWCGHCQRLTPEWKKAATAL---KDVVKVGAVDADKHHSLGGQYGVQGFPTIKI 103
Query: 123 FRNGNRTHPEEYTGPRDAEGIAE 145
F N+ PE+Y G R E I +
Sbjct: 104 F-GSNKNRPEDYQGGRTGEAIVD 125
Score = 70.5 bits (171), Expect = 4e-12
Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 21 GQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPE 80
G G S ++ + K+D I + L +VEFYAPWCGHC+ L PE
Sbjct: 140 GGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199
Query: 81 YSKAAAVLAAESM-VVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139
++ AA+ + ++ V LA VD + LA +G+ +PT+K F+ G P +Y G R
Sbjct: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGE--SPVDYDGGRT 257
Query: 140 AEGI 143
I
Sbjct: 258 RSDI 261
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/207 (29%), Positives = 92/207 (44%), Gaps = 26/207 (12%)
Query: 315 VAADNEHVL--QYFGLKAEAAPTLRLVNLETTKKYAPVD------GGPVTAASITAFCHA 366
V AD H L QY + PT+++ + K P D G + A+++A
Sbjct: 81 VDADKHHSLGGQY---GVQGFPTIKIFG---SNKNRPEDYQGGRTGEAIVDAALSALRQL 134
Query: 367 V---LNGQVKPYLLSQEIPPDWD-QRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCK 422
V L G+ Y ++ D ++ V L +F++ D V+FYAPWC HCK
Sbjct: 135 VKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCK 194
Query: 423 EMAPAWEALAE--KYQDHEDIIIAELDATANELDA--FAVHGFPTLKYFPAGPGRKVIEY 478
+ P W A A K Q + +A +DAT N++ A + + GFPT+K F G +
Sbjct: 195 NLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDG 254
Query: 479 KSTRDLETFSKFLDNGGVLPTEEPPEE 505
TR + S+ LD + PP E
Sbjct: 255 GRTRS-DIVSRALD---LFSDNAPPPE 277
Score = 54.3 bits (129), Expect = 3e-07
Identities = 25/81 (30%), Positives = 37/81 (45%)
Query: 393 LVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANE 452
L NF + V+FYAPWC HC+ + P W+ A +D + + D +
Sbjct: 30 LTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSL 89
Query: 453 LDAFAVHGFPTLKYFPAGPGR 473
+ V GFPT+K F + R
Sbjct: 90 GGQYGVQGFPTIKIFGSNKNR 110
>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
[Homo sapiens]
Length = 406
Score = 70.1 bits (170), Expect = 5e-12
Identities = 45/159 (28%), Positives = 73/159 (45%), Gaps = 5/159 (3%)
Query: 39 PKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAE---SMVV 95
P I L + L LV FYA WC Q L P + +A+ V+ E V
Sbjct: 26 PVTTEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQV 85
Query: 96 TLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSA 155
A+VD ++A+ + +++YPTLK FRNG EY G R + +A+++R++
Sbjct: 86 VFARVDCDQHSDIAQRYRISKYPTLKLFRNG-MMMKREYRGQRSVKALADYIRQQKSDPI 144
Query: 156 MRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALA 194
+ D A L + +IG+F+ ++ F +A
Sbjct: 145 QEIRDLAEITTLDRSK-RNIIGYFEQKDSDNYRVFERVA 182
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 12/127 (9%)
Query: 385 WDQRPVKTLVGKNFEQVAFDETKN----VFVKFYAPWCTHCKEMAPAWE----ALAEKYQ 436
W PV T + + + DE N V FYA WC + + P +E + E++
Sbjct: 22 WVFTPVTTEI-TSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFP 80
Query: 437 DHEDIIIAELDATANE--LDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNG 494
+ ++ A +D + + + +PTLK F G K EY+ R ++ + ++
Sbjct: 81 NENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK-REYRGQRSVKALADYIRQQ 139
Query: 495 GVLPTEE 501
P +E
Sbjct: 140 KSDPIQE 146
>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
Length = 454
Score = 68.6 bits (166), Expect = 1e-11
Identities = 34/90 (37%), Positives = 51/90 (56%), Gaps = 3/90 (3%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122
LV+FYAPWCGHC+ L P +++ + + V + K+D + +A EFGV YPT+K
Sbjct: 45 LVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKL 104
Query: 123 FRNGNRTHPEEYTGPRDAEGIAEWLRRRVG 152
+ G+ + Y GPR + I E+ R G
Sbjct: 105 LK-GDLAY--NYRGPRTKDDIIEFAHRVSG 131
Score = 49.7 bits (117), Expect = 7e-06
Identities = 31/95 (32%), Positives = 45/95 (47%), Gaps = 9/95 (9%)
Query: 402 AFDETKNV---FVKFYAPWCTHCKEMAPAW-EALAEKYQDHEDIIIAELDATANELDA-- 455
+F E +N V FYAPWC HCK++ P W E E + + ++DAT+ A
Sbjct: 34 SFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASE 93
Query: 456 FAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKF 490
F V G+PT+K G Y+ R + +F
Sbjct: 94 FGVRGYPTIKLL---KGDLAYNYRGPRTKDDIIEF 125
>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
sapiens]
Length = 793
Score = 63.9 bits (154), Expect = 3e-10
Identities = 32/91 (35%), Positives = 49/91 (53%), Gaps = 5/91 (5%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLK- 121
+++FYAPWCG CQ APE+ A ++ + V KVD A + ++ G+ YPT+K
Sbjct: 692 VIDFYAPWCGPCQNFAPEFELLARMIKGK---VKAGKVDCQAYAQTCQKAGIRAYPTVKF 748
Query: 122 -FFRNGNRTHPEEYTGPRDAEGIAEWLRRRV 151
F+ R EE RDA+ IA + ++
Sbjct: 749 YFYERAKRNFQEEQINTRDAKAIAALISEKL 779
Score = 56.6 bits (135), Expect = 5e-08
Identities = 33/96 (34%), Positives = 49/96 (51%), Gaps = 6/96 (6%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122
LV+F+APWC C+AL PE +A+ +L + TL D L + + YPT
Sbjct: 472 LVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTL---DCTVHEGLCNMYNIQAYPTTVV 528
Query: 123 FRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRL 158
F N+++ EY G AE I E++ + PS + L
Sbjct: 529 F---NQSNIHEYEGHHSAEQILEFIEDLMNPSVVSL 561
Score = 53.9 bits (128), Expect = 3e-07
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 6/120 (5%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122
+V+FY+PWC CQ L PE+ + A L ++ + +D + V YP ++F
Sbjct: 580 MVDFYSPWCHPCQVLMPEWKRMARTLTG---LINVGSIDCQQYHSFCAQENVQRYPEIRF 636
Query: 123 F--RNGNRTHPEEYTG-PRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFF 179
F ++ H Y G RDA + W + + L + ++ ++ G++ VI F+
Sbjct: 637 FPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTDLTPQTFSEKVLQGKNHWVIDFY 696
Score = 50.1 bits (118), Expect = 5e-06
Identities = 33/115 (28%), Positives = 49/115 (42%), Gaps = 5/115 (4%)
Query: 44 ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGP 103
I+ L R A+ V FY+P C HC LAP + A + ++ + V+
Sbjct: 131 IITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDG---LLRIGAVNCG 187
Query: 104 AQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRL 158
R L GV YP+L FR+G P +Y G R E + + + V + L
Sbjct: 188 DDRMLCRMKGVNSYPSLFIFRSG--MAPVKYHGDRSKESLVSFAMQHVRSTVTEL 240
Score = 41.6 bits (96), Expect = 0.002
Identities = 19/75 (25%), Positives = 32/75 (42%)
Query: 393 LVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANE 452
L + F + + + FYAPWC C+ AP +E LA + + A A
Sbjct: 675 LTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYAQT 734
Query: 453 LDAFAVHGFPTLKYF 467
+ +PT+K++
Sbjct: 735 CQKAGIRAYPTVKFY 749
Score = 39.7 bits (91), Expect = 0.007
Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 3/105 (2%)
Query: 386 DQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAE 445
D + TL + F+ A + + FV FY+P C+HC ++AP W A++ I
Sbjct: 127 DDPEIITLERREFD-AAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRIGAVN 185
Query: 446 LDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKF 490
V+ +P+L F + G ++Y R E+ F
Sbjct: 186 CGDDRMLCRMKGVNSYPSLFIFRS--GMAPVKYHGDRSKESLVSF 228
Score = 34.3 bits (77), Expect = 0.29
Identities = 37/180 (20%), Positives = 66/180 (36%), Gaps = 27/180 (15%)
Query: 291 RELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPV 350
R LL A+ GQ+ F +D +E + + + +A PT + N +Y
Sbjct: 484 RALLPELRRASNLLYGQLKFGTLDCTV-HEGLCNMYNI--QAYPTTVVFNQSNIHEYE-- 538
Query: 351 DGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNV- 409
G +A I F ++N V +L F ++ N
Sbjct: 539 --GHHSAEQILEFIEDLMNPSVV------------------SLTPTTFNELVTQRKHNEV 578
Query: 410 -FVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFP 468
V FY+PWC C+ + P W+ +A ++ + + V +P +++FP
Sbjct: 579 WMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQQYHSFCAQENVQRYPEIRFFP 638
Score = 32.7 bits (73), Expect = 0.83
Identities = 24/106 (22%), Positives = 45/106 (42%), Gaps = 10/106 (9%)
Query: 390 VKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDAT 449
V TL +NF ++ + V F+APWC C+ + P + + + LD T
Sbjct: 455 VTTLGPQNFPA---NDKEPWLVDFFAPWCPPCRALLPELRRASNLL--YGQLKFGTLDCT 509
Query: 450 ANE--LDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDN 493
+E + + + +PT F + EY+ E +F+++
Sbjct: 510 VHEGLCNMYNIQAYPTTVVFNQS---NIHEYEGHHSAEQILEFIED 552
>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
sapiens]
Length = 604
Score = 55.8 bits (133), Expect = 9e-08
Identities = 40/121 (33%), Positives = 55/121 (45%), Gaps = 10/121 (8%)
Query: 7 PVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTL-GLALREHPALLVE 65
P LLLLLL G RS P D + +L T+ G L A VE
Sbjct: 12 PSLLLLLLWLLAVPGANAAPRSALYSP-------SDPLTLLQADTVRGAVLGSRSAWAVE 64
Query: 66 FYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELA--EEFGVTEYPTLKFF 123
F+A WCGHC A AP + A + A + LA +D + A +F + +PT++FF
Sbjct: 65 FFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFF 124
Query: 124 R 124
+
Sbjct: 125 K 125
Score = 49.3 bits (116), Expect = 9e-06
Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 12/109 (11%)
Query: 411 VKFYAPWCTHCKEMAPAWEALAEKYQD-HEDIIIAELDATANELDA----FAVHGFPTLK 465
V+F+A WC HC AP W+ALAE + + +A LD A F + GFPT++
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 466 YFPA--GPGRKVIEYKSTRDLETFSKFL-----DNGGVLPTEEPPEEPA 507
+F A G + + D++T + L + P PP EPA
Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPA 171
>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
sapiens]
Length = 747
Score = 55.8 bits (133), Expect = 9e-08
Identities = 40/121 (33%), Positives = 55/121 (45%), Gaps = 10/121 (8%)
Query: 7 PVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTL-GLALREHPALLVE 65
P LLLLLL G RS P D + +L T+ G L A VE
Sbjct: 12 PSLLLLLLWLLAVPGANAAPRSALYSP-------SDPLTLLQADTVRGAVLGSRSAWAVE 64
Query: 66 FYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELA--EEFGVTEYPTLKFF 123
F+A WCGHC A AP + A + A + LA +D + A +F + +PT++FF
Sbjct: 65 FFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFF 124
Query: 124 R 124
+
Sbjct: 125 K 125
Score = 49.3 bits (116), Expect = 9e-06
Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 12/109 (11%)
Query: 411 VKFYAPWCTHCKEMAPAWEALAEKYQD-HEDIIIAELDATANELDA----FAVHGFPTLK 465
V+F+A WC HC AP W+ALAE + + +A LD A F + GFPT++
Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122
Query: 466 YFPA--GPGRKVIEYKSTRDLETFSKFL-----DNGGVLPTEEPPEEPA 507
+F A G + + D++T + L + P PP EPA
Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPA 171
>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
Length = 166
Score = 53.5 bits (127), Expect = 5e-07
Identities = 28/91 (30%), Positives = 53/91 (58%), Gaps = 5/91 (5%)
Query: 62 LLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLK 121
++V+F+A WCG C+ L P K ++A + V +AKVD +LA E+ V+ PT+
Sbjct: 81 VVVDFHAQWCGPCKILGPRLEK---MVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVL 137
Query: 122 FFRNGNRTHPEEYTGPRDAEGIAEWLRRRVG 152
+NG+ +++ G +D + + +L++ +G
Sbjct: 138 AMKNGDVV--DKFVGIKDEDQLEAFLKKLIG 166
Score = 35.4 bits (80), Expect = 0.13
Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 5/100 (5%)
Query: 395 GKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELD 454
G +F+ + V V F+A WC CK + P E + K H +++A++D +
Sbjct: 67 GPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAK--QHGKVVMAKVDIDDHTDL 124
Query: 455 A--FAVHGFPTLKYFPAGP-GRKVIEYKSTRDLETFSKFL 491
A + V PT+ G K + K LE F K L
Sbjct: 125 AIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKL 164
>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
Length = 280
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/135 (29%), Positives = 59/135 (43%), Gaps = 27/135 (20%)
Query: 6 LPVLLLLLLRASCPW--GQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALL 63
+P+ +L+LL PW G+ R ++E E + + +
Sbjct: 9 VPLAVLVLLLWGAPWTHGRRSNVRVITDENWRELLEGD--------------------WM 48
Query: 64 VEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFF 123
+EFYAPWC CQ L PE+ A E + V +AKVD Q L+ F +T PT+
Sbjct: 49 IEFYAPWCPACQNLQPEWESFAE--WGEDLEVNIAKVDVTEQPGLSGRFIITALPTIYHC 106
Query: 124 RNGNRTHPEEYTGPR 138
++G Y GPR
Sbjct: 107 KDGEF---RRYQGPR 118
Score = 48.5 bits (114), Expect = 1e-05
Identities = 27/85 (31%), Positives = 44/85 (51%), Gaps = 6/85 (7%)
Query: 411 VKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANE--LDAFAVHGFPTLKYFP 468
++FYAPWC C+ + P WE+ AE +D E + IA++D T F + PT+ +
Sbjct: 49 IEFYAPWCPACQNLQPEWESFAEWGEDLE-VNIAKVDVTEQPGLSGRFIITALPTIYHCK 107
Query: 469 AGPGRKVIEYKSTRDLETFSKFLDN 493
G R+ Y+ R + F F+ +
Sbjct: 108 DGEFRR---YQGPRTKKDFINFISD 129
>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
Length = 698
Score = 50.8 bits (120), Expect = 3e-06
Identities = 39/137 (28%), Positives = 62/137 (45%), Gaps = 13/137 (9%)
Query: 6 LPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTL-GLALREHPALLV 64
LP LL+LL A+ G AR ED + VL ++ G A LV
Sbjct: 33 LPRLLVLLAAAAVGPGAGGAARLYRAG--------EDAVWVLDSGSVRGATANSSAAWLV 84
Query: 65 EFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELA--EEFGVTEYPTLKF 122
+FY+ WCGHC AP + A + + + +A +D ++ A ++ + YPT ++
Sbjct: 85 QFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRY 144
Query: 123 FRNGNR--THPEEYTGP 137
F+ + T E + GP
Sbjct: 145 FKAFTKEFTTGENFKGP 161
Score = 50.1 bits (118), Expect = 5e-06
Identities = 39/118 (33%), Positives = 52/118 (44%), Gaps = 24/118 (20%)
Query: 411 VKFYAPWCTHCKEMAPAWEALAEKYQDHEDII-IAELDATANELDA----FAVHGFPTLK 465
V+FY+ WC HC AP W ALA +D I +A LD + A + +H +PT +
Sbjct: 84 VQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFR 143
Query: 466 YFPA------------GPGRKVIEYKSTRDLETFSKFLDN--GGVLPTEEPPEEPAAP 509
YF A GP R E ++ R +T FL N G P P +P P
Sbjct: 144 YFKAFTKEFTTGENFKGPDR---ELRTVR--QTMIDFLQNHTEGSRPPACPRLDPIQP 196
>gi|95113651 glutaredoxin 3 [Homo sapiens]
Length = 335
Score = 43.9 bits (102), Expect = 4e-04
Identities = 22/75 (29%), Positives = 39/75 (52%), Gaps = 4/75 (5%)
Query: 54 LALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFG 113
L L+ L+V F+APW C + ++ A LA E V+ K++ E++E++
Sbjct: 26 LRLKAKSLLVVHFWAPWAPQCAQM----NEVMAELAKELPQVSFVKLEAEGVPEVSEKYE 81
Query: 114 VTEYPTLKFFRNGNR 128
++ PT FF+N +
Sbjct: 82 ISSVPTFLFFKNSQK 96
>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
Length = 958
Score = 43.1 bits (100), Expect = 6e-04
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 37 EIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVT 96
+ P + I ++ T + + +L+ +YAPWCG C +L + + A L ++ T
Sbjct: 658 QFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTF--T 715
Query: 97 LAKVDGPAQRELAEEFGVTEYPTLKFF 123
+A++D +Q +L EF V PT+ FF
Sbjct: 716 VARID-VSQNDLPWEFMVDRLPTVLFF 741
Score = 41.2 bits (95), Expect = 0.002
Identities = 42/174 (24%), Positives = 77/174 (44%), Gaps = 11/174 (6%)
Query: 10 LLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLA---LREHPALLVEF 66
LLL L+ +C + + P++ PP +L L + L A R+ +L+ F
Sbjct: 76 LLLALKFTC--SRAKDVIIPAK-PPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFF 132
Query: 67 YAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNG 126
YAPWCG A E +AA+ L+ + + V + + + F +P + +
Sbjct: 133 YAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHF--FYFPVIYLYHRS 190
Query: 127 NRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQ 180
P EY GP A I +++RR + P + + ++ + + V+G+F+
Sbjct: 191 --FGPIEYKGPMSAVYIEKFVRRVMKP-LLYIPSQSELLDFLSNYEPGVLGYFE 241
Score = 39.7 bits (91), Expect = 0.007
Identities = 30/120 (25%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 366 AVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMA 425
+VL +K +L+ Q + + F +V + ++V + +YAPWC C +
Sbjct: 641 SVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQK-QDVLLLYYAPWCGFCPSLN 699
Query: 426 PAWEALAEKYQDHEDIIIAELDATANELD-AFAVHGFPTLKYFPAGPGRKVIEYKSTRDL 484
+ LA + +A +D + N+L F V PT+ +FP RK + K D+
Sbjct: 700 HIFIQLARNL-PMDTFTVARIDVSQNDLPWEFMVDRLPTVLFFPC--NRKDLSVKYPEDV 756
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 40.8 bits (94), Expect = 0.003
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 14/107 (13%)
Query: 28 SPSEE-----PPEE--EIPKEDGI-LVLSRHTLGLALREHPALLV--EFYAPWCGHCQAL 77
+PS+E P EE E P+ D + ++LS+ +L+E LV +F A WCG C+ +
Sbjct: 360 TPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTI 419
Query: 78 APEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFR 124
P + L+ + V +VD E+ E + PT +F++
Sbjct: 420 RPFFH----ALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYK 462
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 40.8 bits (94), Expect = 0.003
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 14/107 (13%)
Query: 28 SPSEE-----PPEE--EIPKEDGI-LVLSRHTLGLALREHPALLV--EFYAPWCGHCQAL 77
+PS+E P EE E P+ D + ++LS+ +L+E LV +F A WCG C+ +
Sbjct: 427 TPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTI 486
Query: 78 APEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFR 124
P + L+ + V +VD E+ E + PT +F++
Sbjct: 487 RPFFH----ALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYK 529
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 40.8 bits (94), Expect = 0.003
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 14/107 (13%)
Query: 28 SPSEE-----PPEE--EIPKEDGI-LVLSRHTLGLALREHPALLV--EFYAPWCGHCQAL 77
+PS+E P EE E P+ D + ++LS+ +L+E LV +F A WCG C+ +
Sbjct: 360 TPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTI 419
Query: 78 APEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFR 124
P + L+ + V +VD E+ E + PT +F++
Sbjct: 420 RPFFH----ALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYK 462
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 40.0 bits (92), Expect = 0.005
Identities = 33/96 (34%), Positives = 47/96 (48%), Gaps = 15/96 (15%)
Query: 390 VKTLVGKNFEQVAFDET--KNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELD 447
VK + K Q A D K V V F A WC CK + P + +L+EKY ++I E+D
Sbjct: 2 VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKY---SNVIFLEVD 58
Query: 448 A-----TANELDAFAVHGFPTLKYFPAGPGRKVIEY 478
A+E + V PT ++F G+KV E+
Sbjct: 59 VDDCQDVASECE---VKCMPTFQFFK--KGQKVGEF 89
Score = 37.4 bits (85), Expect = 0.034
Identities = 20/67 (29%), Positives = 35/67 (52%), Gaps = 4/67 (5%)
Query: 62 LLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLK 121
++V+F A WCG C+ + P + L+ + V +VD +++A E V PT +
Sbjct: 23 VVVDFSATWCGPCKMIKPFFHS----LSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQ 78
Query: 122 FFRNGNR 128
FF+ G +
Sbjct: 79 FFKKGQK 85
>gi|7705696 thioredoxin domain containing 12 [Homo sapiens]
Length = 172
Score = 37.7 bits (86), Expect = 0.026
Identities = 19/73 (26%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
Query: 62 LLVEFYAPWCGHCQALAPEYSKAAAV--LAAESMVVTLAKVDGPAQRELAEEFGVTEYPT 119
L+V + WCG C+AL P+++++ + L+ ++V L + P + + + G P
Sbjct: 57 LMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGY--IPR 114
Query: 120 LKFFRNGNRTHPE 132
+ F + HPE
Sbjct: 115 ILFLDPSGKVHPE 127
>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
sapiens]
Length = 349
Score = 37.4 bits (85), Expect = 0.034
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 5/53 (9%)
Query: 381 IPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAE 433
+PP+ Q V+ + N+ V E +KFYAPWC C++ WEA A+
Sbjct: 32 LPPE--QSRVQPMTASNWTLVMEGEW---MLKFYAPWCPSCQQTDSEWEAFAK 79
Score = 37.0 bits (84), Expect = 0.044
Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122
+++FYAPWC CQ E+ A E + +++ KVD + L+ F VT P
Sbjct: 56 MLKFYAPWCPSCQQTDSEWE--AFAKNGEILQISVGKVDVIQEPGLSGRFFVTTLPAFFH 113
Query: 123 FRNGNRTHPEEYTGPRDAEGIAEWL 147
++G Y GP E + ++
Sbjct: 114 AKDGIF---RRYRGPGIFEDLQNYI 135
>gi|224493723 hypothetical protein LOC100130311 [Homo sapiens]
Length = 190
Score = 33.1 bits (74), Expect = 0.64
Identities = 20/37 (54%), Positives = 22/37 (59%), Gaps = 3/37 (8%)
Query: 30 SEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEF 66
S EPPE PK G+L + TLGL LRE A LV F
Sbjct: 53 SLEPPE---PKMQGMLPAPKPTLGLVLREATASLVSF 86
>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
sapiens]
Length = 562
Score = 33.1 bits (74), Expect = 0.64
Identities = 25/98 (25%), Positives = 38/98 (38%), Gaps = 14/98 (14%)
Query: 435 YQDHEDIIIAELDATANELDAFAVHGF-------------PTLKYFPAGPGRKVIEYK-S 480
+ D E D +L A AVH F ++ F GP +Y+ S
Sbjct: 209 FDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLS 268
Query: 481 TRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANST 518
D + + P ++P +P AP P+PPA+ T
Sbjct: 269 QDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPT 306
>gi|94421469 disulfide isomerase [Homo sapiens]
Length = 360
Score = 33.1 bits (74), Expect = 0.64
Identities = 17/62 (27%), Positives = 25/62 (40%), Gaps = 4/62 (6%)
Query: 63 LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122
LV FY PWC +LAP ++ A + +D L+ FG P +
Sbjct: 212 LVLFYTPWCRFSASLAPHFNSLPRAFPA----LHFLALDASQHSSLSTRFGTVAVPNILL 267
Query: 123 FR 124
F+
Sbjct: 268 FQ 269
>gi|29893564 microspherule protein 1 isoform 1 [Homo sapiens]
Length = 462
Score = 32.3 bits (72), Expect = 1.1
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 12/113 (10%)
Query: 74 CQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEE 133
CQA+ + +A A + ++++ A+ +L + G T PTL+ F++ HP+
Sbjct: 189 CQAMRQLHPEAIAAIQSKALF-------SKAEEQLLSKVGSTSQPTLETFQDLLHRHPDA 241
Query: 134 YTGPRDAEGI-AEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDE 185
+ R A+ + A W ++ LED+ Q L G ++ +DL D+
Sbjct: 242 FYLARTAKALQAHW---QLMKQYYLLEDQ-TVQPLPKGDQVLNFSDAEDLIDD 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,980,462
Number of Sequences: 37866
Number of extensions: 986163
Number of successful extensions: 4392
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 4238
Number of HSP's gapped (non-prelim): 109
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.