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Search of human proteins with 92087055
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|92087055 PERQ amino acid rich, with GYF domain 1 [Homo
sapiens]
(1035 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|92087055 PERQ amino acid rich, with GYF domain 1 [Homo sapiens] 2104 0.0
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 756 0.0
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 756 0.0
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 744 0.0
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 743 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 74 7e-13
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 62 3e-09
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 60 8e-09
gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo sa... 58 5e-08
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 56 2e-07
gi|110347429 mediator complex subunit 12 [Homo sapiens] 55 4e-07
gi|221139761 zinc finger protein 853 [Homo sapiens] 54 1e-06
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 54 1e-06
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 54 1e-06
gi|148746195 trichohyalin [Homo sapiens] 53 1e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 53 2e-06
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 52 2e-06
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 52 3e-06
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 52 3e-06
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 52 3e-06
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 52 3e-06
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 52 3e-06
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 52 3e-06
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 52 4e-06
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 52 4e-06
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 52 4e-06
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 52 4e-06
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 52 4e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 51 5e-06
>gi|92087055 PERQ amino acid rich, with GYF domain 1 [Homo sapiens]
Length = 1035
Score = 2104 bits (5451), Expect = 0.0
Identities = 1035/1035 (100%), Positives = 1035/1035 (100%)
Query: 1 MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEEL 60
MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEEL
Sbjct: 1 MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEEL 60
Query: 61 QDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGRGS 120
QDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGRGS
Sbjct: 61 QDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGRGS 120
Query: 121 TRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFE 180
TRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFE
Sbjct: 121 TRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFE 180
Query: 181 EGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGW 240
EGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGW
Sbjct: 181 EGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGW 240
Query: 241 REHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDED 300
REHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDED
Sbjct: 241 REHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDED 300
Query: 301 EEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLP 360
EEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLP
Sbjct: 301 EEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLP 360
Query: 361 PQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPPGDLE 420
PQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPPGDLE
Sbjct: 361 PQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPPGDLE 420
Query: 421 DDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYK 480
DDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYK
Sbjct: 421 DDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYK 480
Query: 481 DPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPP 540
DPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPP
Sbjct: 481 DPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPP 540
Query: 541 PLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPP 600
PLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPP
Sbjct: 541 PLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPP 600
Query: 601 PPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEA 660
PPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEA
Sbjct: 601 PPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEA 660
Query: 661 SLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRR 720
SLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRR
Sbjct: 661 SLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRR 720
Query: 721 QEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLE 780
QEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLE
Sbjct: 721 QEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLE 780
Query: 781 GERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGL 840
GERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGL
Sbjct: 781 GERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGL 840
Query: 841 WEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQD 900
WEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQD
Sbjct: 841 WEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQD 900
Query: 901 GFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLE 960
GFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLE
Sbjct: 901 GFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLE 960
Query: 961 RRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGY 1020
RRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGY
Sbjct: 961 RRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGY 1020
Query: 1021 SLHGSSGEIESVDDY 1035
SLHGSSGEIESVDDY
Sbjct: 1021 SLHGSSGEIESVDDY 1035
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 756 bits (1953), Expect = 0.0
Identities = 430/844 (50%), Positives = 542/844 (64%), Gaps = 131/844 (15%)
Query: 1 MAAET--LNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPE 58
MAAET LNFGPEWLRALS GGS+ SPP SPA+PKYKLADYRYGREEMLAL++K+NK+P
Sbjct: 1 MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPS 60
Query: 59 ELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGR 118
+L DKEF +LQ+EPL PLAL P TEEEQRNFS+SVNS AVLRL G+G G + G RGR
Sbjct: 61 DLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGR 120
Query: 119 GSTRSRGRGRGDSCFYQRSIEEGDGAFGRSP-REIQRSQSWDDRGERRFEKSARRDGARC 177
S+R RGRGRG+ FYQRS +E +G FGR RE+ RSQSW++RG+RRFEK R+D R
Sbjct: 121 SSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRP 180
Query: 178 GFEEGG---AGPRKEHARSDSENWRSLREEQE-EEEEGSWRLGAGPRRDGDRWRSASPDG 233
FEEGG G + E RS+SENWR REEQ E+E+G WRL AG RRDG+RWR SPDG
Sbjct: 181 NFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRL-AGSRRDGERWRPHSPDG 239
Query: 234 GPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPE 293
PRSAGWREH ERRR+FEFD R G R G GS ++D+D LPE
Sbjct: 240 -PRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGS-----------IDDDRDSLPE 287
Query: 294 WCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSE----------- 342
WCL+D +EEMGTFD+SGAFL LKK KEPIPEEQE+DF+ ++E EE S+
Sbjct: 288 WCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKE 347
Query: 343 ---------------GLE--EEGPEAGGKELTPLPPQEEKS------------------- 366
G+E EE P+ P P + +S
Sbjct: 348 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEK 407
Query: 367 ---------SSPSPLPTLG---------PLWGTNGDGDETAEKEPPAAEDD---IRGIQL 405
S P+ +P+ G PL D PP + +R ++
Sbjct: 408 AEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVET 467
Query: 406 ----SPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHS 461
+PG+GS + P +D+EGLKHL+Q+AEK+VA LQDS+L++E+ + +Q H
Sbjct: 468 PVVGAPGMGSVSTEP---DDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQ----EHR 520
Query: 462 AAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPL 521
A ++PL H A +KW+YKDPQGEIQGPF QEMAEWFQAGYF+MSLLVKR CDE FQPL
Sbjct: 521 AKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPL 580
Query: 522 GEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLP 581
G+++KMWGRVPF+PGP+PPP +G +DQERL +QQEL A Q LQ+QQF L+ +
Sbjct: 581 GDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQF--LIQQQYAQ 638
Query: 582 QCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPD 641
A ++KAAL QQQQQL LQQ Q LK R DQN++P+++RS+SVPD
Sbjct: 639 VLAQQQKAALS----------SQQQQQLALLLQQFQTLK-MRISDQNIIPSVTRSVSVPD 687
Query: 642 SGRLWDVHTSASSQSGGE-ASLWDIPINSSTQGPILEQLQLQHKF------QERREVELR 694
+G +W++ +AS + E S+WD+P++++T GP LEQLQ K QERRE E+R
Sbjct: 688 TGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMR 747
Query: 695 AKREEEERKRREEKRRQQ------QQEEQKRRQEEEELFRRK------HVRQQELLLKLL 742
AKREEEERKR+EE RRQQ QQEE+++R+EEEEL RRK R+QE+ L+
Sbjct: 748 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 807
Query: 743 QQQQ 746
++++
Sbjct: 808 REEE 811
Score = 244 bits (624), Expect = 2e-64
Identities = 169/442 (38%), Positives = 231/442 (52%), Gaps = 96/442 (21%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREE-----KRRQQQQEEQ-------------- 717
E +L+H+ +ER+ EL +R++E ++R++ +R QQQQ++Q
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Query: 718 --------------------KRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSP 757
K +E E R + RQQ L+K LQQQQ
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSG-- 988
Query: 758 PPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPRE----PARAQAPNH--------RVQ 805
W ++K + K+LLE+Q E RQ+ KQ ++ P RA+ H
Sbjct: 989 ---WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSV 1045
Query: 806 LGGLGTAPLNQWVSE-AGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSP 864
G + T P NQW S+ +W D +S +G W+D K G R KN +++
Sbjct: 1046 WGSINTGPPNQWASDLVSSIWSNADTK---NSNMGFWDDAVKEVGP--RNSTNKN-KNNA 1099
Query: 865 SLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMA 924
SLS S +S R KK EEEEKLLKL QG+ + QDGFTQWCEQMLH L+ +LDVP
Sbjct: 1100 SLSKSVG-VSNRQ-NKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTF 1157
Query: 925 VAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQ--------- 975
V+ LKEVESPY+VHDYIR+ LGDT EAKEFAKQFLERRAKQKA+QQRQQQQ
Sbjct: 1158 VSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP 1217
Query: 976 ------------EAW-LSSASLQTAFQANHS----TKLGPGEGSKAKRRALMLHSDPSIL 1018
W ++ ++L + FQ N S + + K K++ M+ +DPS+L
Sbjct: 1218 PQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLL 1277
Query: 1019 GYSLHGSS-----GEIESVDDY 1035
G+S++ SS GEIE++DDY
Sbjct: 1278 GFSVNASSERLNMGEIETLDDY 1299
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 756 bits (1953), Expect = 0.0
Identities = 430/844 (50%), Positives = 542/844 (64%), Gaps = 131/844 (15%)
Query: 1 MAAET--LNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPE 58
MAAET LNFGPEWLRALS GGS+ SPP SPA+PKYKLADYRYGREEMLAL++K+NK+P
Sbjct: 1 MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPS 60
Query: 59 ELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGR 118
+L DKEF +LQ+EPL PLAL P TEEEQRNFS+SVNS AVLRL G+G G + G RGR
Sbjct: 61 DLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGR 120
Query: 119 GSTRSRGRGRGDSCFYQRSIEEGDGAFGRSP-REIQRSQSWDDRGERRFEKSARRDGARC 177
S+R RGRGRG+ FYQRS +E +G FGR RE+ RSQSW++RG+RRFEK R+D R
Sbjct: 121 SSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRP 180
Query: 178 GFEEGG---AGPRKEHARSDSENWRSLREEQE-EEEEGSWRLGAGPRRDGDRWRSASPDG 233
FEEGG G + E RS+SENWR REEQ E+E+G WRL AG RRDG+RWR SPDG
Sbjct: 181 NFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRL-AGSRRDGERWRPHSPDG 239
Query: 234 GPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPE 293
PRSAGWREH ERRR+FEFD R G R G GS ++D+D LPE
Sbjct: 240 -PRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGS-----------IDDDRDSLPE 287
Query: 294 WCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSE----------- 342
WCL+D +EEMGTFD+SGAFL LKK KEPIPEEQE+DF+ ++E EE S+
Sbjct: 288 WCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKE 347
Query: 343 ---------------GLE--EEGPEAGGKELTPLPPQEEKS------------------- 366
G+E EE P+ P P + +S
Sbjct: 348 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEK 407
Query: 367 ---------SSPSPLPTLG---------PLWGTNGDGDETAEKEPPAAEDD---IRGIQL 405
S P+ +P+ G PL D PP + +R ++
Sbjct: 408 AEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVET 467
Query: 406 ----SPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHS 461
+PG+GS + P +D+EGLKHL+Q+AEK+VA LQDS+L++E+ + +Q H
Sbjct: 468 PVVGAPGMGSVSTEP---DDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQ----EHR 520
Query: 462 AAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPL 521
A ++PL H A +KW+YKDPQGEIQGPF QEMAEWFQAGYF+MSLLVKR CDE FQPL
Sbjct: 521 AKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPL 580
Query: 522 GEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLP 581
G+++KMWGRVPF+PGP+PPP +G +DQERL +QQEL A Q LQ+QQF L+ +
Sbjct: 581 GDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQF--LIQQQYAQ 638
Query: 582 QCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPD 641
A ++KAAL QQQQQL LQQ Q LK R DQN++P+++RS+SVPD
Sbjct: 639 VLAQQQKAALS----------SQQQQQLALLLQQFQTLK-MRISDQNIIPSVTRSVSVPD 687
Query: 642 SGRLWDVHTSASSQSGGE-ASLWDIPINSSTQGPILEQLQLQHKF------QERREVELR 694
+G +W++ +AS + E S+WD+P++++T GP LEQLQ K QERRE E+R
Sbjct: 688 TGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMR 747
Query: 695 AKREEEERKRREEKRRQQ------QQEEQKRRQEEEELFRRK------HVRQQELLLKLL 742
AKREEEERKR+EE RRQQ QQEE+++R+EEEEL RRK R+QE+ L+
Sbjct: 748 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 807
Query: 743 QQQQ 746
++++
Sbjct: 808 REEE 811
Score = 244 bits (624), Expect = 2e-64
Identities = 169/442 (38%), Positives = 231/442 (52%), Gaps = 96/442 (21%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREE-----KRRQQQQEEQ-------------- 717
E +L+H+ +ER+ EL +R++E ++R++ +R QQQQ++Q
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Query: 718 --------------------KRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSP 757
K +E E R + RQQ L+K LQQQQ
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSG-- 988
Query: 758 PPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPRE----PARAQAPNH--------RVQ 805
W ++K + K+LLE+Q E RQ+ KQ ++ P RA+ H
Sbjct: 989 ---WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSV 1045
Query: 806 LGGLGTAPLNQWVSE-AGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSP 864
G + T P NQW S+ +W D +S +G W+D K G R KN +++
Sbjct: 1046 WGSINTGPPNQWASDLVSSIWSNADTK---NSNMGFWDDAVKEVGP--RNSTNKN-KNNA 1099
Query: 865 SLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMA 924
SLS S +S R KK EEEEKLLKL QG+ + QDGFTQWCEQMLH L+ +LDVP
Sbjct: 1100 SLSKSVG-VSNRQ-NKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTF 1157
Query: 925 VAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQ--------- 975
V+ LKEVESPY+VHDYIR+ LGDT EAKEFAKQFLERRAKQKA+QQRQQQQ
Sbjct: 1158 VSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP 1217
Query: 976 ------------EAW-LSSASLQTAFQANHS----TKLGPGEGSKAKRRALMLHSDPSIL 1018
W ++ ++L + FQ N S + + K K++ M+ +DPS+L
Sbjct: 1218 PQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLL 1277
Query: 1019 GYSLHGSS-----GEIESVDDY 1035
G+S++ SS GEIE++DDY
Sbjct: 1278 GFSVNASSERLNMGEIETLDDY 1299
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 744 bits (1920), Expect = 0.0
Identities = 428/865 (49%), Positives = 539/865 (62%), Gaps = 152/865 (17%)
Query: 1 MAAET--LNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPE 58
MAAET LNFGPEWLRALS GGS+ SPP SPA+PKYKLADYRYGREEMLAL++K+NK+P
Sbjct: 1 MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPS 60
Query: 59 ELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGR 118
+L DKEF +LQ+EPL PLAL P TEEEQRNFS+SVNS AVLRL G+G G + G RGR
Sbjct: 61 DLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGR 120
Query: 119 GSTRSRGRGRGDSCFYQRSIEEGDGAFGR-SPREIQRSQSWDDRGERRFEKSARRD---- 173
S+R RGRGRG+ FYQRS +E +G FGR RE+ RSQSW++RG+RRFEK R+D
Sbjct: 121 SSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGKK 180
Query: 174 ------------------GARCGFEEGG---AGPRKEHARSDSENWRSLREEQE-EEEEG 211
R FEEGG G + E RS+SENWR REEQ E+E+G
Sbjct: 181 NGYYCMYSPVLLLGQPLCQGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDG 240
Query: 212 SWRLGAGPRRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGG 271
WRL AG RRDG+RWR SPD GPRSAGWREH ERRR+FEFD R G R G G
Sbjct: 241 GWRL-AGSRRDGERWRPHSPD-GPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSG 298
Query: 272 SSHLRRCRAPEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDF 331
S ++D+D LPEWCL+D +EEMGTFD+SGAFL LKK KEPIPEEQE+DF
Sbjct: 299 S-----------IDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDF 347
Query: 332 QGLEEEEEPSEG---------------------------LEEEGPEAGGKELTPLPPQEE 364
+ ++E EE S+ EE P+ P P +
Sbjct: 348 RPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVASEETPQTSSSSARPGTPSDH 407
Query: 365 KS----------------------------SSPSPLPTLG---------PLWGTNGDGDE 387
+S S P+ +P+ G PL D
Sbjct: 408 QSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTAS 467
Query: 388 TAEKEPPAAED---DIRGIQL----SPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQ 440
PP + +R ++ +PG+GS + P +D+EGLKHL+Q+AEK+VA LQ
Sbjct: 468 PLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEP---DDEEGLKHLEQQAEKMVAYLQ 524
Query: 441 DSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQ 500
DS+L++E+ + +Q H A ++PL H A +KW+YKDPQGEIQGPF QEMAEWFQ
Sbjct: 525 DSALDDERLASKLQ----EHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQ 580
Query: 501 AGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAA 560
AGYF+MSLLVKR CDE FQPLG+++KMWGRVPF+PGP+PPP +G +DQERL +QQEL A
Sbjct: 581 AGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTAL 640
Query: 561 ALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALK 620
Q LQ+QQF L+ + A ++KAAL QQQQQL LQQ Q LK
Sbjct: 641 YQMQHLQYQQF--LIQQQYAQVLAQQQKAALS----------SQQQQQLALLLQQFQTLK 688
Query: 621 PPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGE-ASLWDIPINSSTQGPILEQL 679
R DQN++P+++RS+SVPD+G +W++ +AS + E S+WD+P++++T GP LEQL
Sbjct: 689 -MRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQL 747
Query: 680 QLQHKF------QERREVELRAKREEEERKRREEKRRQQ------QQEEQKRRQEEEELF 727
Q K QERRE E+RAKREEEERKR+EE RRQQ QQEE+++R+EEEEL
Sbjct: 748 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 807
Query: 728 RRK------HVRQQELLLKLLQQQQ 746
RRK R+QE+ L+ ++++
Sbjct: 808 RRKQEEALRRQREQEIALRRQREEE 832
Score = 244 bits (624), Expect = 2e-64
Identities = 169/442 (38%), Positives = 231/442 (52%), Gaps = 96/442 (21%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREE-----KRRQQQQEEQ-------------- 717
E +L+H+ +ER+ EL +R++E ++R++ +R QQQQ++Q
Sbjct: 892 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951
Query: 718 --------------------KRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSP 757
K +E E R + RQQ L+K LQQQQ
Sbjct: 952 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSG-- 1009
Query: 758 PPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPRE----PARAQAPNH--------RVQ 805
W ++K + K+LLE+Q E RQ+ KQ ++ P RA+ H
Sbjct: 1010 ---WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSV 1066
Query: 806 LGGLGTAPLNQWVSE-AGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSP 864
G + T P NQW S+ +W D +S +G W+D K G R KN +++
Sbjct: 1067 WGSINTGPPNQWASDLVSSIWSNADTK---NSNMGFWDDAVKEVGP--RNSTNKN-KNNA 1120
Query: 865 SLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMA 924
SLS S +S R KK EEEEKLLKL QG+ + QDGFTQWCEQMLH L+ +LDVP
Sbjct: 1121 SLSKSVG-VSNRQ-NKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTF 1178
Query: 925 VAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQ--------- 975
V+ LKEVESPY+VHDYIR+ LGDT EAKEFAKQFLERRAKQKA+QQRQQQQ
Sbjct: 1179 VSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP 1238
Query: 976 ------------EAW-LSSASLQTAFQANHS----TKLGPGEGSKAKRRALMLHSDPSIL 1018
W ++ ++L + FQ N S + + K K++ M+ +DPS+L
Sbjct: 1239 PQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLL 1298
Query: 1019 GYSLHGSS-----GEIESVDDY 1035
G+S++ SS GEIE++DDY
Sbjct: 1299 GFSVNASSERLNMGEIETLDDY 1320
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 743 bits (1917), Expect = 0.0
Identities = 424/844 (50%), Positives = 536/844 (63%), Gaps = 137/844 (16%)
Query: 1 MAAET--LNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPE 58
MAAET LNFGPEWLRALS GGS+ SPP SPA+PKYKLADYRYGREEMLAL++K+NK+P
Sbjct: 1 MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPS 60
Query: 59 ELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGR 118
+L DKEF +LQ+EPL PLAL P TEEEQRNFS+SVNS AVLRL G+G G + G RGR
Sbjct: 61 DLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGR 120
Query: 119 GSTRSRGRGRGDSCFYQRSIEEGDGAFGRSP-REIQRSQSWDDRGERRFEKSARRDGARC 177
S+R RGRGRG+ FYQRS +E +G FGR RE+ RSQSW++RG+RRFEK R+D R
Sbjct: 121 SSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRP 180
Query: 178 GFEEGG---AGPRKEHARSDSENWRSLREEQE-EEEEGSWRLGAGPRRDGDRWRSASPDG 233
FEEGG G + E RS+SENWR REEQ E+E+G WRL AG RRDG+RWR
Sbjct: 181 NFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRL-AGSRRDGERWR------ 233
Query: 234 GPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPE 293
P S GWREH ERRR+FEFD R G R G GS ++D+D LPE
Sbjct: 234 -PHSPGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGS-----------IDDDRDSLPE 281
Query: 294 WCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSE----------- 342
WCL+D +EEMGTFD+SGAFL LKK KEPIPEEQE+DF+ ++E EE S+
Sbjct: 282 WCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKE 341
Query: 343 ---------------GLE--EEGPEAGGKELTPLPPQEEKS------------------- 366
G+E EE P+ P P + +S
Sbjct: 342 PDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEK 401
Query: 367 ---------SSPSPLPTLG---------PLWGTNGDGDETAEKEPPAAEDD---IRGIQL 405
S P+ +P+ G PL D PP + +R ++
Sbjct: 402 AEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVET 461
Query: 406 ----SPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHS 461
+PG+GS + P +D+EGLKHL+Q+AEK+VA LQDS+L++E+ + +Q H
Sbjct: 462 PVVGAPGMGSVSTEP---DDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQ----EHR 514
Query: 462 AAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPL 521
A ++PL H A +KW+YKDPQGEIQGPF QEMAEWFQAGYF+MSLLVKR CDE FQPL
Sbjct: 515 AKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPL 574
Query: 522 GEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLP 581
G+++KMWGRVPF+PGP+PPP +G +DQERL +QQEL A Q LQ+QQF L+ +
Sbjct: 575 GDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQF--LIQQQYAQ 632
Query: 582 QCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPD 641
A ++KAAL QQQQQL LQQ Q LK R DQN++P+++RS+SVPD
Sbjct: 633 VLAQQQKAALS----------SQQQQQLALLLQQFQTLK-MRISDQNIIPSVTRSVSVPD 681
Query: 642 SGRLWDVHTSASSQSGGE-ASLWDIPINSSTQGPILEQLQLQHKF------QERREVELR 694
+G +W++ +AS + E S+WD+P++++T GP LEQLQ K QERRE E+R
Sbjct: 682 TGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMR 741
Query: 695 AKREEEERKRREEKRRQQ------QQEEQKRRQEEEELFRRK------HVRQQELLLKLL 742
AKREEEERKR+EE RRQQ QQEE+++R+EEEEL RRK R+QE+ L+
Sbjct: 742 AKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQ 801
Query: 743 QQQQ 746
++++
Sbjct: 802 REEE 805
Score = 244 bits (624), Expect = 2e-64
Identities = 169/442 (38%), Positives = 231/442 (52%), Gaps = 96/442 (21%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREE-----KRRQQQQEEQ-------------- 717
E +L+H+ +ER+ EL +R++E ++R++ +R QQQQ++Q
Sbjct: 865 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924
Query: 718 --------------------KRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSP 757
K +E E R + RQQ L+K LQQQQ
Sbjct: 925 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSG-- 982
Query: 758 PPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPRE----PARAQAPNH--------RVQ 805
W ++K + K+LLE+Q E RQ+ KQ ++ P RA+ H
Sbjct: 983 ---WGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSV 1039
Query: 806 LGGLGTAPLNQWVSE-AGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSP 864
G + T P NQW S+ +W D +S +G W+D K G R KN +++
Sbjct: 1040 WGSINTGPPNQWASDLVSSIWSNADTK---NSNMGFWDDAVKEVGP--RNSTNKN-KNNA 1093
Query: 865 SLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMA 924
SLS S +S R KK EEEEKLLKL QG+ + QDGFTQWCEQMLH L+ +LDVP
Sbjct: 1094 SLSKSVG-VSNRQ-NKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTF 1151
Query: 925 VAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQ--------- 975
V+ LKEVESPY+VHDYIR+ LGDT EAKEFAKQFLERRAKQKA+QQRQQQQ
Sbjct: 1152 VSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP 1211
Query: 976 ------------EAW-LSSASLQTAFQANHS----TKLGPGEGSKAKRRALMLHSDPSIL 1018
W ++ ++L + FQ N S + + K K++ M+ +DPS+L
Sbjct: 1212 PQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLL 1271
Query: 1019 GYSLHGSS-----GEIESVDDY 1035
G+S++ SS GEIE++DDY
Sbjct: 1272 GFSVNASSERLNMGEIETLDDY 1293
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 73.9 bits (180), Expect = 7e-13
Identities = 89/327 (27%), Positives = 125/327 (38%), Gaps = 43/327 (13%)
Query: 113 GTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARR 172
G ++ G GRGD + EEG E +R + D+G E+
Sbjct: 639 GKAKSVGEAEDGPEGRGDG-----TCEEGSSGAEHWQDE-EREKGEKDKGRGEMERPGEG 692
Query: 173 DGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPD 232
+ EE +E + + E QE EE G G G +GDR +
Sbjct: 693 EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752
Query: 233 GGPRSAGWRE--HGERRRKFEFDLRGDRGG---CGEEEGRGGGGSSHLRRCRAPEGFEED 287
G + G E GER ++ + +R G GEEEG G EG EE+
Sbjct: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG------------EGEEEE 800
Query: 288 KDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEE 347
+G E E EE G + G + KG +E EE E + + E EEE EG EEE
Sbjct: 801 TEGRGE-----EKEEGG--EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
Query: 348 GPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSP 407
G G +E +EE G G+G+E E E E +
Sbjct: 854 GEGKGEEEGEEGEGEEEGEEGEGE----GEEEEGEGEGEEEGEGEGEEEEGE-------- 901
Query: 408 GVGSSAGPPGDLEDDEGLKHLQQEAEK 434
G G G G+ E++EG ++E E+
Sbjct: 902 GEGEEEG-EGEGEEEEGEGKGEEEGEE 927
Score = 68.6 bits (166), Expect = 3e-11
Identities = 79/287 (27%), Positives = 113/287 (39%), Gaps = 27/287 (9%)
Query: 118 RGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARC 177
R +G GD + EG G E++ + + +GER E+
Sbjct: 780 RAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGE----- 834
Query: 178 GFEEGGAGPRKEHARSDSENWRSLREEQEE---EEEGSWRLGAGPRRDGDRWRSASPDGG 234
G EE G G +E + E EE EE EEEG G G +G+ +G
Sbjct: 835 GEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG- 893
Query: 235 PRSAGWREHGERRRKFEFDLRGDRG---GCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGL 291
G E GE + E + G+ G GEEEG G G EG EE+ +G
Sbjct: 894 ---EGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEG----------EGEEEEGEGE 940
Query: 292 PEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEA 351
E + +EE G ++ +G +E E +E + +G EEEE EG EEEG E
Sbjct: 941 GEDGEGEGEEEEGEWEGEEEEGE-GEGEEEGEGEGEEGEGEG-EEEEGEGEGEEEEGEEE 998
Query: 352 GGKELTPLPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAED 398
G +E E + G + G G+G+ E+ E+
Sbjct: 999 GEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045
Score = 59.7 bits (143), Expect = 1e-08
Identities = 71/254 (27%), Positives = 98/254 (38%), Gaps = 48/254 (18%)
Query: 104 GKGAGPPLAGTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGE 163
G+G G G G+G+ EEG+ G E + ++ GE
Sbjct: 833 GEGEEEEGEGEEEEGEGEEEEGEGKGE--------EEGEEGEGEEEGEEGEGEGEEEEGE 884
Query: 164 RRFEKSARRDGARCGFEEGGAGPRKEHARSDSEN----WRSLREEQEEEEEGSWRLGAGP 219
E+ +G EE G G +E + E + E +E E EG G G
Sbjct: 885 GEGEEEGEGEGE----EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGE 940
Query: 220 RRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCR 279
DG+ G E GE + E + G GEEEG G G
Sbjct: 941 GEDGE------------GEGEEEEGEWEGEEE-----EGEGEGEEEGEGEGEEGE----- 978
Query: 280 APEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQG-LEEEE 338
EG EE+ +G E ++E EE G + G ++G E EE+E + +G +E EE
Sbjct: 979 -GEGEEEEGEGEGE---EEEGEEEGEEEGEGE----EEGEGEG-EEEEEGEVEGEVEGEE 1029
Query: 339 EPSEGLEEEGPEAG 352
EG EEEG E G
Sbjct: 1030 GEGEGEEEEGEEEG 1043
Score = 40.8 bits (94), Expect = 0.007
Identities = 40/171 (23%), Positives = 57/171 (33%), Gaps = 2/171 (1%)
Query: 104 GKGAGPPLAGTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGE 163
G+G G G G G G G+ + EEG+ E + + + GE
Sbjct: 917 GEGKGEEEGEEGEGEGE-EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGE 975
Query: 164 RRFEKSARRDGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDG 223
+ +G G EE G +E + E EE+E E EG G +G
Sbjct: 976 EGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE-GEEGEGEG 1034
Query: 224 DRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSH 274
+ G E R R+ E + G GEEE G +
Sbjct: 1035 EEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEY 1085
Score = 31.2 bits (69), Expect = 5.3
Identities = 15/58 (25%), Positives = 33/58 (56%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQ 734
E+ + K + R E+E + E+E ++ E K+R +++EQK R++ + R + + +
Sbjct: 672 EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE 729
Score = 30.4 bits (67), Expect = 9.0
Identities = 15/39 (38%), Positives = 24/39 (61%)
Query: 687 ERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEE 725
E EVE ++EE ERK+ E ++++ EE+ + E EE
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEE 798
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 62.0 bits (149), Expect = 3e-09
Identities = 77/292 (26%), Positives = 116/292 (39%), Gaps = 48/292 (16%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ- 735
E + Q + Q RRE E + + EE ER+R+EE+ R++ +EE++R + E+E RR+ +Q
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Query: 736 --ELLLKLLQQQQAV-------PVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLH 786
E+L + L Q+QA+ P P PPP +K E + H
Sbjct: 478 HLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAP---------EPKAH 528
Query: 787 KQPPPREPARAQAPNHRVQLGGLGTAPL---NQWVSEAGPLWGGPDKSGGGSSGLGLWE- 842
+P R R + +PL Q S+A G S LWE
Sbjct: 529 YEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQA-----GQRNSTSSIEPRLLWER 583
Query: 843 -----DTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKT---EEEEKLLKLLQG 894
P SG S G NS S P SG R ++ E +L
Sbjct: 584 VEKLVPRPGSGSS----SGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENA 639
Query: 895 IPRPQDGFTQWCEQMLHTLSATGSLDVPMAVAILKEVES---PYDVHDYIRS 943
+ +P+D +++ L G +D+ L+ VE P+ V DY S
Sbjct: 640 VKKPEDK-----KEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSS 686
Score = 46.2 bits (108), Expect = 2e-04
Identities = 34/102 (33%), Positives = 58/102 (56%), Gaps = 13/102 (12%)
Query: 655 QSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAK-------REEEERKRR-- 705
Q G +S+ ++P S+ + L +LQ + +ER E R + RE+EE KR+
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFL---RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL 392
Query: 706 -EEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E ++R +QQ+EQ+RR EE++ R+ RQQE + +Q++
Sbjct: 393 AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEE 434
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 60.5 bits (145), Expect = 8e-09
Identities = 106/448 (23%), Positives = 167/448 (37%), Gaps = 101/448 (22%)
Query: 439 LQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEW 498
L L+ Q Q GLR + ALP G+ GPF +A+
Sbjct: 3636 LPGHGLQPPQGPPGGQAGGLRLTPGGMALP---------------GQPGGPFLNTALAQQ 3680
Query: 499 FQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELA 558
Q + S G GF P ++ G P L Q +L++Q+
Sbjct: 3681 QQQQH-SGGAGSLAGPSGGFFPGNLALRSLG---------PDSRLLQERQLQLQQQRMQL 3730
Query: 559 AAALYQQLQHQQFLQ------LVSSRQLPQCALREKAALGD----LTPPP---------- 598
A L QQ Q QQ Q + +Q ++ ALG L PP
Sbjct: 3731 AQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQL 3790
Query: 599 -PPPPQQQQ-----QQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWD----- 647
P PPQ Q Q+ QQ P+G + +L T SR LS P +
Sbjct: 3791 SPQPPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGH 3850
Query: 648 ------------VHTSASSQSG------------GEASLWDIPINSSTQGPILEQLQLQH 683
H S +G G+ L P+ S Q +QLQ Q
Sbjct: 3851 RLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQ 3910
Query: 684 KFQERREVEL------------RAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH 731
+ Q++++ +L + +++++ +++++++ +QQQQ+ Q+++Q++++ F+++
Sbjct: 3911 QLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQ 3970
Query: 732 VRQQELLLK----LL--QQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQL 785
+QQ LL LL QQQQ V P P + G TLL L G+ Q
Sbjct: 3971 QQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLL---LTGKEQN 4027
Query: 786 HKQPPPREPARAQAPNHRVQLGGLGTAP 813
P A H+ +GT P
Sbjct: 4028 TVDPAVSSEATEGPSTHQGGPLAIGTTP 4055
Score = 46.2 bits (108), Expect = 2e-04
Identities = 110/515 (21%), Positives = 195/515 (37%), Gaps = 89/515 (17%)
Query: 546 MDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQ 605
+DQ R ++++ A Y+ Q QQ Q +Q L AL P Q
Sbjct: 3578 LDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAVL----ALS---------PSQS 3624
Query: 606 QQQLTAFLQQL---QALKPPRG---GDQNLLPTMSRSLSVPDSGRLWDVHTSASSQ---- 655
+ LT QL L+PP+G G L +++P ++T+ + Q
Sbjct: 3625 PRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLTPGGMALPGQPGGPFLNTALAQQQQQQ 3684
Query: 656 -SGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQ 714
SGG SL + G L L+ + R ++ R + +++R + +K +QQQQ
Sbjct: 3685 HSGGAGSL-----AGPSGGFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQ 3739
Query: 715 EEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTL 774
++Q +++ L + ++QQ+ +Q QA+ P PP GL Q LS +
Sbjct: 3740 QQQ----QQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQLSPQ-- 3793
Query: 775 LELQLEGERQLHKQPPPREPARAQAPNHRVQL-----GGLGT-APLNQWVSEAGPLWGGP 828
PP+ P P L G LG P Q + + P
Sbjct: 3794 ---------------PPQGPQGMLGPAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSP 3838
Query: 829 DKSGGGSSGLG---------LWEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIR 879
+ G +G + + GS+ GL + + S LS +P+
Sbjct: 3839 QLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMA---GLSHLQQSLMSHSGQPKLSAQPMG 3895
Query: 880 KKTE-EEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVH 938
+ ++++ L+ Q + + Q Q +Q+ L++ + +
Sbjct: 3896 SLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQQ--------------LQQQQQQQQLQ 3941
Query: 939 DYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGP 998
+ L+ ++ Q +++ +Q+ QQ+QQQQ L+ + + Q ++
Sbjct: 3942 QQQQQ----QLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRTLLSPQQQQQQQVAL 3997
Query: 999 GEGSKAKRRALMLHSDPSILGYSLHGSSGEIESVD 1033
G G AK L S P LG +L + E +VD
Sbjct: 3998 GPGMPAK--PLQHFSSPGALGPTLLLTGKEQNTVD 4030
Score = 35.0 bits (79), Expect = 0.37
Identities = 36/101 (35%), Positives = 41/101 (40%), Gaps = 27/101 (26%)
Query: 314 PLKKGPKEPIPEEQELD-------FQGLE-------EEEEPSEGLEEEGPEAGGKELTPL 359
PL++ P P PEE L F LE EE PS LE P + E +PL
Sbjct: 488 PLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALET--PLSPPPEASPL 545
Query: 360 -PPQEEKSSSPSP--LPTLGPLWGTNGDGDETAEKEPPAAE 397
PP EE SP P LPT P E + PP E
Sbjct: 546 SPPFEESPLSPPPEELPTSPP--------PEASRLSPPPEE 578
Score = 34.3 bits (77), Expect = 0.62
Identities = 79/334 (23%), Positives = 125/334 (37%), Gaps = 67/334 (20%)
Query: 706 EEKRRQQQQEEQKRRQEEEEL-----FRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPL 760
E++ + Q+Q +Q R+Q++E +R K +QQ+ + QQ AV + +PS P L
Sbjct: 3569 EQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQHSAV-LALSPSQSPRL 3627
Query: 761 WAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGG-----------L 809
L Q L H PP+ P QA R+ GG L
Sbjct: 3628 LTKLPGQLLPG--------------HGLQPPQGPPGGQAGGLRLTPGGMALPGQPGGPFL 3673
Query: 810 GTAPLNQWVSEAGPLWGGPDKSGGGSSG-----LGLWEDTPKSGGSLVRGLGLKNSR--- 861
TA Q + GG G S G L L P S R L L+ R
Sbjct: 3674 NTALAQQQQQQHS---GGAGSLAGPSGGFFPGNLALRSLGPDSRLLQERQLQLQQQRMQL 3730
Query: 862 -----SSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGI-PRPQDGFTQWCEQ--MLHTL 913
HL G+ ++ +++ ++ Q + P+PQ Q ++ L
Sbjct: 3731 AQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQTNQALGPKPQGLMPPSSHQGLLVQQL 3790
Query: 914 SAT------GSLDVPMAVAILKEVE----SPYDVHDYIRSCLGDTLEAKEFAKQ---FLE 960
S G L P VA+L++ P H + L + + A+Q +
Sbjct: 3791 SPQPPQGPQGMLG-PAQVAVLQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMG 3849
Query: 961 RR---AKQKASQQRQQQQEAWLSSASLQTAFQAN 991
R A+Q+ QQ+ QQQ + + LQ + ++
Sbjct: 3850 HRLVTAQQQQQQQQHQQQGSMAGLSHLQQSLMSH 3883
Score = 33.5 bits (75), Expect = 1.1
Identities = 42/139 (30%), Positives = 59/139 (42%), Gaps = 25/139 (17%)
Query: 700 EERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPP 759
E K+ +K++Q + Q +Q++++ +QQ LL QA+ +P SSP
Sbjct: 3254 EHEKKELQKKQQLSAQLQPAQQQQQQ-------QQQHSLLSAPGPAQAMSLPHEGSSPS- 3305
Query: 760 LWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVS 819
AG +Q L L L G RQ P P P Q P H +Q AP VS
Sbjct: 3306 -LAGSQQQ-------LSLGLAGARQ-PGLPQPLMP--TQPPAHALQ---QRLAPSMAMVS 3351
Query: 820 EAGPLWGGPDKSGGGSSGL 838
G + G GG +GL
Sbjct: 3352 NQGHMLSG---QHGGQAGL 3367
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 320 KEPIPEEQELDFQGLEEEEEPSEGLEEE----GPEAGGKELTPLPPQEEKSSSP 369
++ +P Q+ D G + +E S GLE + GPE GG + +P+P EK +P
Sbjct: 1814 RKELPTSQKGD-DGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTP 1866
>gi|15826852 acyl-Coenzyme A binding domain containing 3 [Homo
sapiens]
Length = 528
Score = 57.8 bits (138), Expect = 5e-08
Identities = 33/69 (47%), Positives = 46/69 (66%), Gaps = 4/69 (5%)
Query: 683 HKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHV---RQQELLL 739
HK E+ E E + K EEE R+R EE+R + Q+EE+KRR+EEEE RR+ R +E L
Sbjct: 179 HKI-EKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERL 237
Query: 740 KLLQQQQAV 748
+L QQ+Q +
Sbjct: 238 RLEQQKQQI 246
Score = 48.5 bits (114), Expect = 3e-05
Identities = 26/77 (33%), Positives = 48/77 (62%), Gaps = 6/77 (7%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKR---REEKRRQQQQEEQKRRQEEEELFRRKHVR- 733
+++ + + ++R+E E R +REEEER+R EEKRR++++E +R +EE + +R
Sbjct: 180 KIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREEEERLRREEEERRRIEEERLRL 239
Query: 734 --QQELLLKLLQQQQAV 748
Q++ ++ L Q AV
Sbjct: 240 EQQKQQIMAALNSQTAV 256
Score = 35.0 bits (79), Expect = 0.37
Identities = 23/79 (29%), Positives = 41/79 (51%), Gaps = 10/79 (12%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQ----------KRRQEEEEL 726
E+LQ + + + R E E + EEE R+ EE+ R +QQ++Q + Q+
Sbjct: 205 ERLQKEEEKRRREEEERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQ 264
Query: 727 FRRKHVRQQELLLKLLQQQ 745
+ QQ++L++ LQ+Q
Sbjct: 265 QYPGNYEQQQILIRQLQEQ 283
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 56.2 bits (134), Expect = 2e-07
Identities = 34/93 (36%), Positives = 54/93 (58%), Gaps = 10/93 (10%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ- 735
E + Q + Q RRE E + + EE ER+R+EE+ R++ +EE++R + E+E RR+ +Q
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Query: 736 --ELLLKLLQQQQAV-------PVPPAPSSPPP 759
E+L + L Q+QA+ P P PPP
Sbjct: 478 HLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPP 510
Score = 52.0 bits (123), Expect = 3e-06
Identities = 38/131 (29%), Positives = 70/131 (53%), Gaps = 22/131 (16%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
LE+ Q + + R++ + +RE+EE++R EE R++++EE++RR EEE +R+ R+Q
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE---KRRVEREQ 465
Query: 736 ELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLH----KQPPP 791
E + + L+++Q L +Q L + +L L R+ H +QPPP
Sbjct: 466 EYIRRQLEEEQR------------HLEVLQQQLLQEQAML---LHDHRRPHPQHSQQPPP 510
Query: 792 REPARAQAPNH 802
+ R++ H
Sbjct: 511 PQQERSKPSFH 521
Score = 46.2 bits (108), Expect = 2e-04
Identities = 34/102 (33%), Positives = 58/102 (56%), Gaps = 13/102 (12%)
Query: 655 QSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAK-------REEEERKRR-- 705
Q G +S+ ++P S+ + L +LQ + +ER E R + RE+EE KR+
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFL---RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL 392
Query: 706 -EEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E ++R +QQ+EQ+RR EE++ R+ RQQE + +Q++
Sbjct: 393 AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEE 434
>gi|110347429 mediator complex subunit 12 [Homo sapiens]
Length = 2177
Score = 54.7 bits (130), Expect = 4e-07
Identities = 37/144 (25%), Positives = 72/144 (50%), Gaps = 10/144 (6%)
Query: 651 SASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRR 710
SA G S +P Q +Q Q Q + Q++++ + R++++++ ++++
Sbjct: 2034 SAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQ 2093
Query: 711 QQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLS 770
QQQQ++Q+++Q++++ +++ QQ+ QQQQA P P P S P +QGL
Sbjct: 2094 QQQQQQQQQQQQQQQQQQQQQQHQQQ------QQQQAAPPQPQPQSQPQ----FQRQGLQ 2143
Query: 771 MKTLLELQLEGERQLHKQPPPREP 794
+ RQL +Q +P
Sbjct: 2144 QTQQQQQTAALVRQLQQQLSNTQP 2167
Score = 36.6 bits (83), Expect = 0.13
Identities = 22/101 (21%), Positives = 60/101 (59%), Gaps = 22/101 (21%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEEL---------- 726
+Q Q H Q++++ LR +++++++++++++++QQQQ++Q+++ ++++
Sbjct: 2072 QQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQP 2131
Query: 727 -----FRRKHVRQQE------LLLKLLQQQQAVPVPPAPSS 756
F+R+ ++Q + L++ LQQQ + P PS+
Sbjct: 2132 QSQPQFQRQGLQQTQQQQQTAALVRQLQQQLS-NTQPQPST 2171
Score = 34.3 bits (77), Expect = 0.62
Identities = 26/80 (32%), Positives = 35/80 (43%), Gaps = 12/80 (15%)
Query: 550 RLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPP---PQ--- 603
R ++QQ++ QQ Q QQ Q +Q Q ++ PP P P PQ
Sbjct: 2080 RQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQR 2139
Query: 604 ------QQQQQLTAFLQQLQ 617
QQQQQ A ++QLQ
Sbjct: 2140 QGLQQTQQQQQTAALVRQLQ 2159
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 53.5 bits (127), Expect = 1e-06
Identities = 68/274 (24%), Positives = 117/274 (42%), Gaps = 34/274 (12%)
Query: 532 PFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQ-LPQCALREKAA 590
P P S P + +E Q+EL L QQ + QQ Q +Q P L+++
Sbjct: 64 PQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQ-- 121
Query: 591 LGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMS--------RSLSVPDS 642
P Q QQQL+ QLQ K Q L P + + V +
Sbjct: 122 ----------PQQDGQQQLS----QLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQ 167
Query: 643 GRLWDVHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEER 702
RL +Q E + + Q + EQ LQ + ++ ++ +L ++E+ ++
Sbjct: 168 QRLQQQQEQLQTQQAQEQQV--LQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQ 225
Query: 703 KRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLK--LLQQQQAVPVPPAPSSPPPL 760
++ ++++ Q QQ++Q +++ +++ ++QQ+ L+ LL+QQQA L
Sbjct: 226 QQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQA-----QLQQQLLL 280
Query: 761 WAGLAKQGLSMKTLLELQLEGERQLHKQPPPREP 794
Q + LL+ Q E +Q QPPP EP
Sbjct: 281 QQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEP 314
Score = 48.9 bits (115), Expect = 2e-05
Identities = 64/249 (25%), Positives = 104/249 (41%), Gaps = 24/249 (9%)
Query: 548 QERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQQ 607
QE+L+ QQ L QQ Q QQ +Q Q Q L+++ L QQQQ+
Sbjct: 174 QEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQE 233
Query: 608 QLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWDIP- 666
QL QQL L+ Q LL L + +Q + L
Sbjct: 234 QLQQ-QQQLLLLQQQGQLQQQLLQQQQAQLQQ-------QLLEQQQAQLQQQLLLQQQEQ 285
Query: 667 INSSTQGPILEQLQLQHKFQERREVELRAKREEE------------ERKRREEKRRQQQQ 714
+ Q +L+Q Q Q + Q+ + L + EEE E++ ++++ ++Q
Sbjct: 286 LQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQ 345
Query: 715 EEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMK-- 772
+E +R+QE+ +L + Q+L +L QQQQ + P+ G +Q + ++
Sbjct: 346 QELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELT 405
Query: 773 -TLLELQLE 780
ELQLE
Sbjct: 406 PVQPELQLE 414
Score = 46.2 bits (108), Expect = 2e-04
Identities = 63/250 (25%), Positives = 106/250 (42%), Gaps = 62/250 (24%)
Query: 547 DQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQ 606
+Q+RL++QQE QQ Q QQ LQ QL Q ++E+ L QQQQ
Sbjct: 166 EQQRLQQQQEQLQT---QQAQEQQVLQ--QQEQLQQ-QVQEQQLL-----------QQQQ 208
Query: 607 QQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWDIP 666
+QL QQ Q L+ Q L L
Sbjct: 209 EQL----QQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLL--------------------- 243
Query: 667 INSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEEL 726
+ +Q QLQ + ++++ +L+ + E+++ + +++ QQQE+ +++Q+++ L
Sbjct: 244 --------LQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295
Query: 727 FRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQ---LEGER 783
+QQ+ + LQQQQ P P P + L L + LE Q LE ++
Sbjct: 296 ------QQQQ---EQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346
Query: 784 QLHKQPPPRE 793
+L +Q R+
Sbjct: 347 ELERQQEQRQ 356
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/220 (25%), Positives = 94/220 (42%), Gaps = 20/220 (9%)
Query: 546 MDQERLKKQQELAAAALYQQLQHQ-----QFLQLVSSRQLPQCALREKAALGDLTPPPPP 600
+ Q++L +QQE +QQ Q Q Q L L QL Q L+++ A
Sbjct: 211 LQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQ 270
Query: 601 PPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEA 660
Q QQQ L +QLQ + Q LL L +L + E
Sbjct: 271 QAQLQQQLLLQQQEQLQQQQ-----QQQLLQQQQEQLQ---QQQLQPPPLEPEEEEEVEL 322
Query: 661 SLWDIPINSST----QGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEE 716
L + + S Q LE+ Q + QE+R+++L+ +EE ++ E++ QQQQ+
Sbjct: 323 ELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKL---QEELQQLEQQLEQQQQQL 379
Query: 717 QKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSS 756
+++ + E +QQE+ L+L Q + + P++
Sbjct: 380 EQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELVPAA 419
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 53.5 bits (127), Expect = 1e-06
Identities = 74/275 (26%), Positives = 116/275 (42%), Gaps = 58/275 (21%)
Query: 535 PGPSPPPLLGNMDQER---LKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCAL-REKAA 590
P P P M E+ L++ QE + ++LQ QQ + + R L + +E+ +
Sbjct: 1450 PAPFSPLTAQQMKPEKPSTLQRPQE----TVIRELQPQQQPRTIERRDLQYITVSKEELS 1505
Query: 591 LGDLTPPPP------PPPQQQQQQ-----LTAFLQQLQALKPPRGGDQNLLPTMSRSLSV 639
GD P P ++QQQ L+ +Q+LQ+ KP R +++ R L +
Sbjct: 1506 SGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQS-KPDRSAEES---DRLRKLML 1561
Query: 640 PDSGRLWDVHTSASSQSGGEASLWDIPI-----------NSSTQGPILEQLQLQHKFQER 688
+ + + E D+ + T P + L L + R
Sbjct: 1562 EWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARTAMPAISVLDLLQDEERR 1621
Query: 689 REVELRA--KREEEERKRREEKRRQQQQE------EQKRRQEE------EELFRRKHVRQ 734
R+ +L KRE E+R R+EE+RR+Q++E E+KRRQEE E RR+H
Sbjct: 1622 RQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEA 1681
Query: 735 QELLLK---------LLQQQQAVPVP-PAPSSPPP 759
LL+ L + P P PAP +PPP
Sbjct: 1682 ARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPP 1716
Score = 38.1 bits (87), Expect = 0.043
Identities = 21/65 (32%), Positives = 33/65 (50%)
Query: 694 RAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPA 753
R KREE +R +EK R +++ E+KRR++E +L + + L QQ P P+
Sbjct: 1408 RRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPS 1467
Query: 754 PSSPP 758
P
Sbjct: 1468 TLQRP 1472
Score = 33.9 bits (76), Expect = 0.82
Identities = 26/105 (24%), Positives = 47/105 (44%), Gaps = 20/105 (19%)
Query: 690 EVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVP 749
+V +R+ EE +R EK + + +EE++R++ E+E + L Q +
Sbjct: 1402 QVAAAERRKREEHQRWYEKEKARLEEERERKRREQE--------------RKLGQMRTQS 1447
Query: 750 VPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREP 794
+ PAP SP L Q + + LQ E + + P ++P
Sbjct: 1448 LNPAPFSP------LTAQQMKPEKPSTLQRPQETVIRELQPQQQP 1486
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 53.5 bits (127), Expect = 1e-06
Identities = 67/236 (28%), Positives = 106/236 (44%), Gaps = 36/236 (15%)
Query: 686 QERREVELRAKREEEER-------KRREEKRRQQQQEEQKRRQEEE----ELFRRKHVRQ 734
Q+RRE ELR ++E E+R +R EE+RR + ++E KR+Q EE E +R+ ++
Sbjct: 408 QQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQE 467
Query: 735 QELLLKLL-QQQQAVPVPPAP---------SSPPPLWAGLAKQGLSMKTLLELQLEGERQ 784
++ L+ L Q+Q+ PV P S P WA +++K+ L +
Sbjct: 468 RDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKS-QGPALTASQS 526
Query: 785 LHKQPPPREPARAQAPN---HRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGLW 841
+H+QP +A N HRV++ + P SE PL +K SS L
Sbjct: 527 VHEQPTKGLSGFQEALNVTSHRVEMPRQNSDP----TSENPPLPTRIEKF-DRSSWLRQE 581
Query: 842 ED----TPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQ 893
ED P+ S+ L KNS + S L +PIR + + +L+
Sbjct: 582 EDIPPKVPQRTTSISPALARKNSPGNGSALG--PRLGSQPIRASNPDLRRTEPILE 635
Score = 47.0 bits (110), Expect = 9e-05
Identities = 42/145 (28%), Positives = 67/145 (46%), Gaps = 22/145 (15%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQP------- 789
K L++Q+ KQ L+ Q + +R + K+P
Sbjct: 446 YKRKQLEEQRQA----------ERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 790 --PPREPARAQAPNHRVQLGGLGTA 812
P +PA A+ H V + G A
Sbjct: 496 MSPSEKPAWAKEIPHLVAVKSQGPA 520
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 53.5 bits (127), Expect = 1e-06
Identities = 67/236 (28%), Positives = 106/236 (44%), Gaps = 36/236 (15%)
Query: 686 QERREVELRAKREEEER-------KRREEKRRQQQQEEQKRRQEEE----ELFRRKHVRQ 734
Q+RRE ELR ++E E+R +R EE+RR + ++E KR+Q EE E +R+ ++
Sbjct: 408 QQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQE 467
Query: 735 QELLLKLL-QQQQAVPVPPAP---------SSPPPLWAGLAKQGLSMKTLLELQLEGERQ 784
++ L+ L Q+Q+ PV P S P WA +++K+ L +
Sbjct: 468 RDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKS-QGPALTASQS 526
Query: 785 LHKQPPPREPARAQAPN---HRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGLW 841
+H+QP +A N HRV++ + P SE PL +K SS L
Sbjct: 527 VHEQPTKGLSGFQEALNVTSHRVEMPRQNSDP----TSENPPLPTRIEKF-DRSSWLRQE 581
Query: 842 ED----TPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQ 893
ED P+ S+ L KNS + S L +PIR + + +L+
Sbjct: 582 EDIPPKVPQRTTSISPALARKNSPGNGSALG--PRLGSQPIRASNPDLRRTEPILE 635
Score = 47.0 bits (110), Expect = 9e-05
Identities = 42/145 (28%), Positives = 67/145 (46%), Gaps = 22/145 (15%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQP------- 789
K L++Q+ KQ L+ Q + +R + K+P
Sbjct: 446 YKRKQLEEQRQA----------ERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEG 495
Query: 790 --PPREPARAQAPNHRVQLGGLGTA 812
P +PA A+ H V + G A
Sbjct: 496 MSPSEKPAWAKEIPHLVAVKSQGPA 520
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/79 (34%), Positives = 52/79 (65%), Gaps = 8/79 (10%)
Query: 676 LEQLQLQHKFQE--------RREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF 727
LE+ +L+ + QE RRE +LR K+EEE R+++EE+R QQ++ EQ+ + E++L
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 728 RRKHVRQQELLLKLLQQQQ 746
R + R+++ L + ++++
Sbjct: 341 REQEERREQQLRREQEEER 359
Score = 53.1 bits (126), Expect = 1e-06
Identities = 28/64 (43%), Positives = 41/64 (64%), Gaps = 4/64 (6%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQ----EEQKRRQEEEELFRRKHV 732
EQLQL+ + Q R+ R R EE+ +E+ RR++Q+ EEQKRRQE E R +H+
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 733 RQQE 736
R+Q+
Sbjct: 1886 RRQQ 1889
Score = 50.8 bits (120), Expect = 6e-06
Identities = 25/70 (35%), Positives = 44/70 (62%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
+QL+ + + R E +L +REE++ R+E R+ ++E+Q RRQE + FR + +R QE
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Query: 737 LLLKLLQQQQ 746
K L+++Q
Sbjct: 1513 PERKFLEEEQ 1522
Score = 48.9 bits (115), Expect = 2e-05
Identities = 26/60 (43%), Positives = 40/60 (66%), Gaps = 1/60 (1%)
Query: 688 RREVELRAKREEEERKRREEKRRQQQQEEQK-RRQEEEELFRRKHVRQQELLLKLLQQQQ 746
R E E + +R+E +RK REE++ Q++EEQ RRQE + FR + +R QE K L+++Q
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Score = 48.1 bits (113), Expect = 4e-05
Identities = 25/76 (32%), Positives = 53/76 (69%), Gaps = 3/76 (3%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFR---RKHVR 733
+QL+ Q + ++ RE E + +R+E ERK +E+++ ++QE +++ +EEE+L + ++ +R
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 734 QQELLLKLLQQQQAVP 749
+QE K+L+++Q P
Sbjct: 1742 RQERYRKILEEEQLRP 1757
Score = 47.8 bits (112), Expect = 5e-05
Identities = 21/75 (28%), Positives = 46/75 (61%)
Query: 672 QGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH 731
Q + + QL+ K +E R + +RE++ER+ ++E+RR+QQ ++ + E++L R +
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 732 VRQQELLLKLLQQQQ 746
++E L+ Q+++
Sbjct: 357 EERREQQLRREQEEE 371
Score = 47.4 bits (111), Expect = 7e-05
Identities = 26/75 (34%), Positives = 50/75 (66%), Gaps = 8/75 (10%)
Query: 680 QLQHKFQERREVELRAKREEEE-----RKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQ 734
QL+ + +ERRE +LR ++EEE R+ +EE+RR+QQ +++ + E++L R + +R+
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Query: 735 QELLLK---LLQQQQ 746
++ L + L ++QQ
Sbjct: 398 EQQLRREQQLRREQQ 412
Score = 47.0 bits (110), Expect = 9e-05
Identities = 28/69 (40%), Positives = 44/69 (63%), Gaps = 8/69 (11%)
Query: 686 QERREVELRAKREEEERKR-----REEKRRQQQQEEQKRRQEEEELFRRKHVRQQE---L 737
QERR+ +L+ +EEE R+R EE+R QQ++ EQ+ R+E+EE ++ RQ+E L
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528
Query: 738 LLKLLQQQQ 746
+L +QQ
Sbjct: 529 QQRLRSEQQ 537
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/72 (36%), Positives = 46/72 (63%), Gaps = 9/72 (12%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEER-----KRREEKRRQQQQEEQKRRQEEEE----L 726
L++ + + + Q+R E + +RE+EER KR EEKR +Q++ EQ+ ++E+EE L
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 727 FRRKHVRQQELL 738
+R+ R+Q+ L
Sbjct: 579 LKREEERRQQRL 590
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/77 (36%), Positives = 49/77 (63%), Gaps = 1/77 (1%)
Query: 670 STQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRR 729
S + P+ EQ + Q + +ER++ E R EEEE+++R +RR++++E Q +EEE+L RR
Sbjct: 785 SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ-FLEEEEQLQRR 843
Query: 730 KHVRQQELLLKLLQQQQ 746
+ +Q + LQ+ Q
Sbjct: 844 ERAQQLQEEEDGLQEDQ 860
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/77 (37%), Positives = 46/77 (59%), Gaps = 9/77 (11%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQ-------QQQEEQKRRQEEEELFRR 729
EQL+ + + + E EL+ REE E++RR+E+ RQ QQ+EEQ R+E E+ R+
Sbjct: 897 EQLRKEQQLLQEEEEELQ--REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 730 KHVRQQELLLKLLQQQQ 746
+ RQ KL Q+++
Sbjct: 955 ERERQYRKDKKLQQKEE 971
Score = 46.2 bits (108), Expect = 2e-04
Identities = 30/84 (35%), Positives = 55/84 (65%), Gaps = 14/84 (16%)
Query: 677 EQLQLQHKFQERREVELRA----KREEEERKRREEKRRQQQ----QEEQKRRQE---EEE 725
EQ + + + +ERRE +LR +RE++ R+ +EE+RR+QQ QEE++R Q+ E++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 726 LFRRKHVRQQELLLK---LLQQQQ 746
L R + +R+++ L + L ++QQ
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQ 406
Score = 45.8 bits (107), Expect = 2e-04
Identities = 31/73 (42%), Positives = 47/73 (64%), Gaps = 6/73 (8%)
Query: 675 ILEQLQLQHKFQERREVELRAKREEEERKRREEKR-RQQQQEEQKRRQEEEELFRRKHVR 733
ILE+ QL+ ER E +LR R+E +RK REE++ RQ+++E+Q R QE + FR +
Sbjct: 1749 ILEEEQLR---PEREEQQLR--RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803
Query: 734 QQELLLKLLQQQQ 746
+QE + L+ QQ
Sbjct: 1804 RQEREEQQLRPQQ 1816
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/73 (38%), Positives = 49/73 (67%), Gaps = 6/73 (8%)
Query: 680 QLQHKFQERREVELRAK---REEEERKRREEKRRQQQ--QEEQKRRQEEEELFRRKHVRQ 734
QL+ + Q RRE +LR + R E++ +R ++ RR+QQ +E+Q RR++EEE +KH ++
Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQE 441
Query: 735 -QELLLKLLQQQQ 746
+E LK Q+++
Sbjct: 442 RREQRLKREQEER 454
Score = 45.4 bits (106), Expect = 3e-04
Identities = 22/53 (41%), Positives = 39/53 (73%), Gaps = 2/53 (3%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELL 738
QERRE +LR RE+EER+ + KR+++++ Q+R + E++L R + R+++LL
Sbjct: 500 QERREQQLR--REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 11/81 (13%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQK-RRQEEEELF-------- 727
+QL+ Q + Q+ R+ R REEE++ R+E+ R+ ++EEQ+ RRQE E F
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLR 1456
Query: 728 --RRKHVRQQELLLKLLQQQQ 746
R + R++E LL+ ++QQ
Sbjct: 1457 QERHRKFREEEQLLQEREEQQ 1477
Score = 45.1 bits (105), Expect = 4e-04
Identities = 24/68 (35%), Positives = 43/68 (63%), Gaps = 1/68 (1%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
EQ + + + QERRE + +RE++ R+ +EE+R QQ + EQ+ + E++L R + ++E
Sbjct: 316 EQQEERREQQERREQQ-EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 737 LLLKLLQQ 744
L+ QQ
Sbjct: 375 QQLRREQQ 382
Score = 44.7 bits (104), Expect = 5e-04
Identities = 28/81 (34%), Positives = 48/81 (59%), Gaps = 11/81 (13%)
Query: 677 EQLQLQHKFQERREV-------ELRAKREEEE----RKRREEKRRQQQQEEQKRRQEEEE 725
E+ Q Q + QE E ELR +R+EEE R RRE++ R++Q+EE++ +QEE
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 726 LFRRKHVRQQELLLKLLQQQQ 746
+ + +Q+E + L+++Q
Sbjct: 323 EQQERREQQEERREQQLRREQ 343
Score = 44.7 bits (104), Expect = 5e-04
Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 13/122 (10%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF--RRKHVRQ 734
+QL+ + R E +L + EE++ +R+E R+ +++E+Q RRQE E F + +R+
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 735 QELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGER---QLHKQPPP 791
QEL K +++Q L +Q K L E QL ER QL +Q
Sbjct: 1719 QELERKFREEEQLRQETEQEQ--------LRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 792 RE 793
R+
Sbjct: 1771 RK 1772
Score = 44.3 bits (103), Expect = 6e-04
Identities = 27/73 (36%), Positives = 51/73 (69%), Gaps = 4/73 (5%)
Query: 677 EQLQLQH-KFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFR--RKHVR 733
++L+ Q+ K +E ++ E + REE E++RR+E+ RQ ++EE+ +QEEE+L R R+ R
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE-LQQEEEQLLREEREKRR 1132
Query: 734 QQELLLKLLQQQQ 746
+QEL + ++++
Sbjct: 1133 RQELERQYREEEE 1145
Score = 44.3 bits (103), Expect = 6e-04
Identities = 25/77 (32%), Positives = 46/77 (59%), Gaps = 4/77 (5%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRR----KHV 732
EQL+ Q ++++ E E EE++ RR+E+ R+ ++EEQ R++ EE+ R +
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKF 1797
Query: 733 RQQELLLKLLQQQQAVP 749
R++E L + ++QQ P
Sbjct: 1798 REEEQLRQEREEQQLRP 1814
Score = 43.9 bits (102), Expect = 8e-04
Identities = 25/77 (32%), Positives = 49/77 (63%), Gaps = 7/77 (9%)
Query: 677 EQLQLQHKFQERREVELRAKREEEER----KRREEKRRQQQQEEQKRRQEEEELFRRKHV 732
EQ + + +ERRE +LR ++EEE R +R ++ RR+QQ +++ + E++L R + +
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 733 RQQELLLK---LLQQQQ 746
R+++ L + L ++QQ
Sbjct: 408 RREQQLRREQQLRREQQ 424
Score = 43.9 bits (102), Expect = 8e-04
Identities = 23/70 (32%), Positives = 43/70 (61%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
E+ L+ + ++RR EL + EEE ++EE++ +++ E++RRQE E +R + QQE
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 737 LLLKLLQQQQ 746
L ++Q+
Sbjct: 1180 EEQLLREEQE 1189
Score = 43.9 bits (102), Expect = 8e-04
Identities = 21/60 (35%), Positives = 40/60 (66%), Gaps = 3/60 (5%)
Query: 680 QLQHKFQERREVELRAK---REEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
+L+ +++E EV+ + REE E++RR+E RQ ++EE+ +++EE+ L + R+QE
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/80 (33%), Positives = 48/80 (60%), Gaps = 11/80 (13%)
Query: 677 EQLQLQHKFQERR---------EVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF 727
+QL+ Q + Q+RR E +LR +REE++ R+E R+ + +E++ RRQE+E F
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 728 R--RKHVRQQELLLKLLQQQ 745
+ +R+QE +L Q++
Sbjct: 1598 MEDEQQLRRQEGQQQLRQER 1617
Score = 42.7 bits (99), Expect = 0.002
Identities = 27/76 (35%), Positives = 48/76 (63%), Gaps = 7/76 (9%)
Query: 677 EQLQLQHKFQE-RREVELRAKREEEERKRREEKRRQQQQEE------QKRRQEEEELFRR 729
EQ LQ + +E +RE + +R+E+ER+ REE++ QQ++E+ +KRR++E E R
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 730 KHVRQQELLLKLLQQQ 745
K + Q+ +LL ++
Sbjct: 962 KDKKLQQKEEQLLGEE 977
Score = 42.7 bits (99), Expect = 0.002
Identities = 22/60 (36%), Positives = 37/60 (61%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
E+ L + ++RR E K EEE ++EE++ +++ E++RRQE E +R+K QQE
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/77 (36%), Positives = 45/77 (58%), Gaps = 9/77 (11%)
Query: 670 STQGPILEQLQLQHKFQERREVELRAK-REEEERKRREEKRRQQQQEEQKR--------R 720
S +G E+ + + + R +ELR K REE++++RRE + R Q+EE+K R
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 721 QEEEELFRRKHVRQQEL 737
+EEE+L + RQ+EL
Sbjct: 255 KEEEKLQEEEPQRQREL 271
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/69 (39%), Positives = 43/69 (62%), Gaps = 8/69 (11%)
Query: 685 FQERREVELRAK----REEEERKRREEKRRQ---QQQEEQKRRQEEEELFRRKHVRQQEL 737
FQE E E R + R+EEE+ + EE +RQ Q++EEQ R+ E +EL RR+ +++
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL-RRERQEEEQQ 296
Query: 738 LLKLLQQQQ 746
+L ++QQ
Sbjct: 297 QQRLRREQQ 305
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/73 (34%), Positives = 47/73 (64%), Gaps = 6/73 (8%)
Query: 680 QLQHKFQERREVELRAKREEE--ERKRREEKRRQQQQEEQKRRQE----EEELFRRKHVR 733
QL+ + Q RRE +LR ++EEE E+K +E+R Q+ + EQ+ R++ EEE R + R
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 734 QQELLLKLLQQQQ 746
+++ L + ++++
Sbjct: 472 RKQQLKRDQEEER 484
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/79 (34%), Positives = 48/79 (60%), Gaps = 10/79 (12%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEE-----LFRRKH 731
EQ + + +E R +L E+EER++++ +R QQ++ EQ+ ++EEEE +R+H
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 732 V---RQQELLLKLLQQQQA 747
R+QEL + +Q+QA
Sbjct: 677 EEERREQELAEE--EQEQA 693
Score = 42.4 bits (98), Expect = 0.002
Identities = 37/134 (27%), Positives = 65/134 (48%), Gaps = 12/134 (8%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRR--KHVR 733
L + + KF RE E + +R+E ERK EE+++ +Q+ +K R+EE+ L R + +
Sbjct: 1423 LSRQERDRKF---REEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 734 QQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPRE 793
+QE K L+++Q + +Q L + LE E+QLH+Q R+
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRK-------FREQELRSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 794 PARAQAPNHRVQLG 807
+ + R + G
Sbjct: 1533 FLQEEQQLRRQERG 1546
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/73 (32%), Positives = 44/73 (60%), Gaps = 3/73 (4%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRR---KHVR 733
+QL+ + + R + +L +REE++ R+E R+ ++E Q RRQE E+ R + R
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670
Query: 734 QQELLLKLLQQQQ 746
++E LL+ ++QQ
Sbjct: 1671 EEEQLLQEGEEQQ 1683
Score = 42.0 bits (97), Expect = 0.003
Identities = 25/78 (32%), Positives = 47/78 (60%), Gaps = 3/78 (3%)
Query: 672 QGPILEQLQLQHKFQERREVELR---AKREEEERKRREEKRRQQQQEEQKRRQEEEELFR 728
Q + + QL+ + +ERRE L+ KR E+ER+ + KR Q+++ +Q ++EEE +
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588
Query: 729 RKHVRQQELLLKLLQQQQ 746
R Q+E L + L++++
Sbjct: 589 RLKREQEERLEQRLKREE 606
Score = 42.0 bits (97), Expect = 0.003
Identities = 19/53 (35%), Positives = 35/53 (66%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRK 730
Q QL+ + QERRE L+ + EEE ++R ++ ++++ EQ+ +EE+E R +
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Score = 42.0 bits (97), Expect = 0.003
Identities = 27/67 (40%), Positives = 40/67 (59%), Gaps = 8/67 (11%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQE-------EQKRRQEEEELFRR 729
E+LQ + + R E E R +R+E ER+ REE+ QQ++E E++RRQE E +R
Sbjct: 1084 EELQQEEEQLLREEPEKR-RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 730 KHVRQQE 736
+ QQE
Sbjct: 1143 EEEVQQE 1149
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/75 (32%), Positives = 49/75 (65%), Gaps = 5/75 (6%)
Query: 677 EQLQLQHKFQE--RREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRR---KH 731
EQL+ + + Q+ R+E + + + EE++ +R+E++R+ + E+Q RRQE ++ R+ +
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Query: 732 VRQQELLLKLLQQQQ 746
R+ E LL+ ++QQ
Sbjct: 1621 FREDEQLLQEREEQQ 1635
Score = 42.0 bits (97), Expect = 0.003
Identities = 27/81 (33%), Positives = 46/81 (56%), Gaps = 11/81 (13%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERK---------RREEKRRQQQQEEQKRRQEEEELF 727
+QL Q + ++ E E + +R+E E++ R EE+ Q+ +E+Q RRQE + F
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 728 R--RKHVRQQELLLKLLQQQQ 746
R + +R+QE K LQ++Q
Sbjct: 1694 REEEQQLRRQERERKFLQEEQ 1714
Score = 42.0 bits (97), Expect = 0.003
Identities = 36/134 (26%), Positives = 62/134 (46%), Gaps = 21/134 (15%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRR----KHV 732
+QL+ Q ++ RE E + E+E+ RR+E+ R+ +EEQ R + EE+ RR +
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 733 RQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPR 792
R++E L + ++QQ L Q K E QL ER+ + P +
Sbjct: 1774 REEEQLRQEREEQQ-----------------LRSQESDRKFREEEQLRQEREEQQLRPQQ 1816
Query: 793 EPARAQAPNHRVQL 806
+ + ++QL
Sbjct: 1817 RDGKYRWEEEQLQL 1830
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 4/70 (5%)
Query: 680 QLQHKFQERREVELRAKREE--EERKRREEKRRQQQQE--EQKRRQEEEELFRRKHVRQQ 735
QL + +ERR+ L+ ++EE E+R +REE R +Q+E EQ+ ++EE E RR+ + +
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 736 ELLLKLLQQQ 745
E + QQQ
Sbjct: 637 EEQEERRQQQ 646
Score = 41.6 bits (96), Expect = 0.004
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 15/116 (12%)
Query: 688 RREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQA 747
R++ R ++E+EE++RR E Q Q+EE+ RQ++EE RR Q + K + +Q
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 748 VPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHR 803
+ S+ PPL +Q L+ E +Q ++ P E + Q R
Sbjct: 784 L------SARPPLREQRERQ---------LRAEERQQREQRFLPEEEEKEQRRRQR 824
Score = 41.6 bits (96), Expect = 0.004
Identities = 18/57 (31%), Positives = 37/57 (64%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVR 733
++L+ Q++ +E + E EE+ KRR+E+ RQ ++EE+ +RQ+ ++ +R + R
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Score = 41.2 bits (95), Expect = 0.005
Identities = 22/60 (36%), Positives = 41/60 (68%), Gaps = 6/60 (10%)
Query: 680 QLQHKFQERREVELRAK---REEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
QL+ + Q RRE +LR + R E+E +R E+K Q+++E++ +R++EE RR ++++E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE---RRDWLKREE 462
Score = 41.2 bits (95), Expect = 0.005
Identities = 23/68 (33%), Positives = 45/68 (66%), Gaps = 8/68 (11%)
Query: 677 EQLQLQHKFQERREVELRAKREEEER----KRREEKRRQQQQEEQKRRQ----EEEELFR 728
E+ Q + K ++ +E R KREE ER +RRE++ ++++ EE++R+Q EE+E R
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 729 RKHVRQQE 736
++ +R+++
Sbjct: 644 QQQLRREQ 651
Score = 41.2 bits (95), Expect = 0.005
Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 29/89 (32%)
Query: 677 EQLQLQHKFQERREVELRAKREEE--------------ERKRREEKRRQ-------QQQE 715
E+LQ + + + RR+ + R REEE E++RR+E+ RQ QQ+E
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 716 EQ--------KRRQEEEELFRRKHVRQQE 736
EQ +RRQE E+ +R + QQE
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQE 999
Score = 40.8 bits (94), Expect = 0.007
Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 16/77 (20%)
Query: 677 EQLQLQHKFQERREVELRAKRE--------EEERKRREEKRRQQQ----QEEQKRRQ--- 721
E+ Q QERRE L+ ++E EEE +R E++RR+QQ QEE++R +
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 722 -EEEELFRRKHVRQQEL 737
EEEE ++ R+Q+L
Sbjct: 491 LEEEERREQQERREQQL 507
Score = 40.4 bits (93), Expect = 0.009
Identities = 29/63 (46%), Positives = 40/63 (63%), Gaps = 13/63 (20%)
Query: 686 QERREVELRAKREEEERK----RREEKRRQQ----QQE---EQKRRQEEEELFRRKHVRQ 734
QERRE L KRE+EER+ +REE+RRQQ +QE EQ+ ++EE E ++ R+
Sbjct: 560 QERREQRL--KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617
Query: 735 QEL 737
Q L
Sbjct: 618 QRL 620
Score = 40.4 bits (93), Expect = 0.009
Identities = 30/85 (35%), Positives = 48/85 (56%), Gaps = 15/85 (17%)
Query: 677 EQLQLQHKFQERREVELRAKREEEE---------RKRREEKRRQ----QQQEEQKRRQEE 723
EQL + + RR+ R REEEE R+ RE++RRQ Q +EE++ +QEE
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 724 EELFRR--KHVRQQELLLKLLQQQQ 746
E+L R + R+QEL + ++++
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEE 1175
Score = 40.4 bits (93), Expect = 0.009
Identities = 25/85 (29%), Positives = 48/85 (56%), Gaps = 14/85 (16%)
Query: 676 LEQLQLQHKFQERREV---ELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH- 731
LE+ Q H+ Q +R+ E + +R+E ++RR+++ R+ ++EEQ R++ EE+ R+
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 732 ----------VRQQELLLKLLQQQQ 746
VR+QE K ++ +Q
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQ 1602
Score = 40.0 bits (92), Expect = 0.011
Identities = 28/60 (46%), Positives = 38/60 (63%), Gaps = 9/60 (15%)
Query: 686 QERREVELRAKREEEERKRRE--EKRRQQQQEEQKR-----RQEEEELFR--RKHVRQQE 736
QE+ E + +EEEE +RE EKRR+Q+QE Q R +QEEE+L R R+ R+QE
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Score = 40.0 bits (92), Expect = 0.011
Identities = 18/63 (28%), Positives = 41/63 (65%)
Query: 684 KFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQ 743
K E ++ E + REE E++R +E+ RQ ++EE+ +++EE+ L + R+++ L + +
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 744 QQQ 746
+++
Sbjct: 1082 KEE 1084
Score = 40.0 bits (92), Expect = 0.011
Identities = 31/82 (37%), Positives = 43/82 (52%), Gaps = 5/82 (6%)
Query: 677 EQLQLQHKF----QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHV 732
EQ Q K QE + E + +R+E ERK REE R+QQ+EEQ+ RQ E+ ++
Sbjct: 1849 EQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ-VGEIKSQEGK 1907
Query: 733 RQQELLLKLLQQQQAVPVPPAP 754
LL Q +VPV +P
Sbjct: 1908 GHGRLLEPGTHQFASVPVRSSP 1929
Score = 39.7 bits (91), Expect = 0.015
Identities = 20/68 (29%), Positives = 41/68 (60%), Gaps = 5/68 (7%)
Query: 684 KFQERREVELRAKREEEERKRREEKR-----RQQQQEEQKRRQEEEELFRRKHVRQQELL 738
K +E E + +RE++ R+ +EE+R RQ+++E ++R E+ RR+ ++E L
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 739 LKLLQQQQ 746
LK ++++
Sbjct: 550 LKREEEKR 557
Score = 39.7 bits (91), Expect = 0.015
Identities = 26/71 (36%), Positives = 39/71 (54%), Gaps = 12/71 (16%)
Query: 678 QLQLQHKFQERREVELRAKRE-----EEERKRREEKRRQQQQE-------EQKRRQEEEE 725
Q + + + Q+ E LR +RE E ER+ REE+ QQ++E E +RRQE E
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 726 LFRRKHVRQQE 736
+R++ QQE
Sbjct: 1079 QYRKEEELQQE 1089
Score = 39.7 bits (91), Expect = 0.015
Identities = 24/66 (36%), Positives = 40/66 (60%), Gaps = 7/66 (10%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ------QEEQKRRQEEEELFRRK 730
E++Q + + R E E R +R+E ER+ REE+ QQ+ +E++KRRQE E +R +
Sbjct: 1144 EEVQQEEEQLLREEPEKR-RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 731 HVRQQE 736
Q++
Sbjct: 1203 EELQRQ 1208
Score = 39.3 bits (90), Expect = 0.019
Identities = 24/58 (41%), Positives = 38/58 (65%), Gaps = 6/58 (10%)
Query: 686 QERREVELRAKRE----EEERKRREEKRRQQQQEEQKRRQEEEELF--RRKHVRQQEL 737
Q R++ EL+ + E EE KRR ++R +Q +EE++ +QEEE+L R+ R+QEL
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Score = 39.3 bits (90), Expect = 0.019
Identities = 22/59 (37%), Positives = 39/59 (66%), Gaps = 2/59 (3%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
+QL+ Q + ++ RE ELR+ +E ERK EE+++ +Q+ Q++ +EE+ RR+ QQ
Sbjct: 1492 QQLRRQERDRKFREQELRS--QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Score = 38.9 bits (89), Expect = 0.025
Identities = 27/76 (35%), Positives = 46/76 (60%), Gaps = 7/76 (9%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEE------QKRRQEEEELFRRK 730
E+LQ Q + Q RE + +R+E ER+ REE+ QQ++E+ +KRR++E E R+
Sbjct: 1114 EELQ-QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Query: 731 HVRQQELLLKLLQQQQ 746
Q+ +LL+++Q
Sbjct: 1173 EEELQQEEEQLLREEQ 1188
Score = 38.9 bits (89), Expect = 0.025
Identities = 28/82 (34%), Positives = 47/82 (57%), Gaps = 11/82 (13%)
Query: 675 ILEQLQLQHKFQERREVELRAKR--EEEERKRREEKR-----RQQQQEEQKRRQEEEELF 727
+L + Q + + QERR + R + EEE+ +R E+K R+ Q+E+Q R+E EE
Sbjct: 1270 LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKR 1329
Query: 728 RRKHV----RQQELLLKLLQQQ 745
RR+ R++E LL+ ++Q
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQ 1351
Score = 38.5 bits (88), Expect = 0.033
Identities = 22/74 (29%), Positives = 48/74 (64%), Gaps = 5/74 (6%)
Query: 677 EQLQLQHKFQERREVELRA----KREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHV 732
EQ + + +ERRE +LR +RE++ R+ ++ +R QQ + EQ+ R+ E++L R + +
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQL 419
Query: 733 RQQELLLKLLQQQQ 746
R+++ L + ++++
Sbjct: 420 RREQQLRREQEEER 433
Score = 38.5 bits (88), Expect = 0.033
Identities = 24/75 (32%), Positives = 44/75 (58%), Gaps = 6/75 (8%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQ-----KRRQEEEELFRRK 730
L++ +++ QE R E R KREE E +RR++ + ++QEE+ +R Q+E R K
Sbjct: 602 LKREEVERLEQEERR-EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 731 HVRQQELLLKLLQQQ 745
++E L + L+++
Sbjct: 661 REEEEERLEQRLKRE 675
Score = 38.5 bits (88), Expect = 0.033
Identities = 23/63 (36%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 674 PILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVR 733
P E+ + + + + RE EL+ EEE+ +RRE R QQ QEE+ QE++E R + R
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRE--RAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 734 QQE 736
+ +
Sbjct: 870 RDQ 872
Score = 38.5 bits (88), Expect = 0.033
Identities = 20/60 (33%), Positives = 35/60 (58%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
E+ L + + RR EL + +EE ++EE++ +++ E++RRQE E R + QQE
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Score = 38.1 bits (87), Expect = 0.043
Identities = 21/69 (30%), Positives = 39/69 (56%), Gaps = 4/69 (5%)
Query: 682 QHKFQERREVELRAKREEEER----KRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQEL 737
+ K QE R +EEEE+ +R+E +R +Q++E+Q++R E+ RRK ++
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 738 LLKLLQQQQ 746
+ ++QQ
Sbjct: 317 QQEERREQQ 325
Score = 38.1 bits (87), Expect = 0.043
Identities = 21/59 (35%), Positives = 34/59 (57%), Gaps = 5/59 (8%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
Q LQH E++E + E+ER+R +++ R +EEQ R+E++E RR Q+E
Sbjct: 1264 QQDLQHLLGEQQE-----RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317
Score = 38.1 bits (87), Expect = 0.043
Identities = 27/67 (40%), Positives = 39/67 (58%), Gaps = 12/67 (17%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQ-------EEQKRRQEEEELFRRKHVRQQELL 738
QER E LR R+E +RK REE+ R Q+Q E++ RRQE E F ++ +Q+L
Sbjct: 1346 QEREEQPLR--RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE---EQQLR 1400
Query: 739 LKLLQQQ 745
+ +QQ
Sbjct: 1401 CQEREQQ 1407
Score = 37.7 bits (86), Expect = 0.056
Identities = 27/77 (35%), Positives = 48/77 (62%), Gaps = 9/77 (11%)
Query: 677 EQLQLQHKFQERR----EVELRAK-REEEERKRREEKRRQQQQEEQKRRQEEEELFR--R 729
E+ +L+ + +ER+ E +LR + RE++ R+ R+ K R ++E+Q RQE + FR
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR--EEEQQLSRQERDRKFREEE 1436
Query: 730 KHVRQQELLLKLLQQQQ 746
+ VR+QE K L+++Q
Sbjct: 1437 QQVRRQERERKFLEEEQ 1453
Score = 37.4 bits (85), Expect = 0.074
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 10/75 (13%)
Query: 682 QHKFQERREVELRAK---REEEERKRREEKRRQ-------QQQEEQKRRQEEEELFRRKH 731
+ K++E E++ + REE E++RR+E RQ QQ+EEQ R+E E+ ++
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Query: 732 VRQQELLLKLLQQQQ 746
RQ +L Q+++
Sbjct: 1047 ERQYREEEELQQEEE 1061
Score = 37.4 bits (85), Expect = 0.074
Identities = 24/88 (27%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 666 PINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQ---QQEEQKRRQE 722
P+ + + +L+H+ Q R+ +E + +ER+R+ K QQ Q+ EQ+ RQ+
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 723 EEELFR--RKHVRQQELLLKLLQQQQAV 748
+ FR + + +QE K +++Q V
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQV 1439
Score = 37.4 bits (85), Expect = 0.074
Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 6/72 (8%)
Query: 677 EQLQLQHKFQERREVELRAKREEEE--RKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQ 734
EQL+ + + Q+ R E K EEE R+ REE++ + QQ + K R EEE+L + +
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL----QLEE 1832
Query: 735 QELLLKLLQQQQ 746
QE L+ + +Q
Sbjct: 1833 QEQRLRQERDRQ 1844
Score = 37.0 bits (84), Expect = 0.096
Identities = 31/125 (24%), Positives = 61/125 (48%), Gaps = 10/125 (8%)
Query: 679 LQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEE----QKRRQEEEELFRRKHVRQ 734
LQ + + +++R E R ++ EEE +R ++RQ+Q+ E +++ +++E L +R R+
Sbjct: 110 LQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRR 169
Query: 735 QELLLKLLQQQQAVPVPPAPSSPPPLWAGLA------KQGLSMKTLLELQLEGERQLHKQ 788
E L + Q+ Q A G ++ L + LLEL+ +G + +Q
Sbjct: 170 DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQ 229
Query: 789 PPPRE 793
R+
Sbjct: 230 RRERQ 234
Score = 36.6 bits (83), Expect = 0.13
Identities = 28/74 (37%), Positives = 45/74 (60%), Gaps = 11/74 (14%)
Query: 682 QHKFQERREVELRAKREEEE---RKRREEKRRQQ---QQEEQKRR---QEEEELFRRKHV 732
+ K Q+RRE + R +EEEE RKR R+++ Q+EE +R+ QEEEE R+ +
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK--L 281
Query: 733 RQQELLLKLLQQQQ 746
+QEL + +++Q
Sbjct: 282 ERQELRRERQEEEQ 295
Score = 36.6 bits (83), Expect = 0.13
Identities = 21/64 (32%), Positives = 37/64 (57%), Gaps = 5/64 (7%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRR-----QEEEELFRRKH 731
E+ + Q + ++ RE E + EE+ + EKRR+Q+ E Q R+ QEEE+L R +
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 732 VRQQ 735
+++
Sbjct: 1039 EKRR 1042
Score = 36.2 bits (82), Expect = 0.16
Identities = 23/81 (28%), Positives = 48/81 (59%), Gaps = 14/81 (17%)
Query: 680 QLQHKFQERREV---ELRAKREEEERKRREEKRRQQQ---------QEEQKRRQEE--EE 725
+L+ + +ERR+ E +R E+ER++++ KR Q++ +EE++R Q+E E+
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 726 LFRRKHVRQQELLLKLLQQQQ 746
RR+ ++E LK ++++
Sbjct: 506 QLRREQEERREQRLKRQEEEE 526
Score = 36.2 bits (82), Expect = 0.16
Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 21/79 (26%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKR------------------REEK--RRQQQQEE 716
++L+ +H+ +ERRE EL + +E+ R+R R+ K R ++QE
Sbjct: 670 QRLKREHE-EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 717 QKRRQEEEELFRRKHVRQQ 735
Q+RRQE+EE RR+ Q
Sbjct: 729 QRRRQEQEEKRRRRESELQ 747
Score = 36.2 bits (82), Expect = 0.16
Identities = 23/58 (39%), Positives = 39/58 (67%), Gaps = 8/58 (13%)
Query: 686 QERREVELRAKRE-----EEERKRREEKRRQQQQEEQKRRQEEEELFR--RKHVRQQE 736
Q R++ +L+ K E E E++RR+E R ++ +EE++ +QEEE+L R R+ R+QE
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQE-REKKYREEEELQQEEEQLLREEREKRRRQE 1015
Score = 36.2 bits (82), Expect = 0.16
Identities = 27/83 (32%), Positives = 45/83 (54%), Gaps = 13/83 (15%)
Query: 677 EQLQLQHKFQERREVELRAKREEE------ERKRREEKRRQ-------QQQEEQKRRQEE 723
E+ +LQ + ++ RE E + EE+ E +RR+E RQ QQ+EEQ R+E
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 724 EELFRRKHVRQQELLLKLLQQQQ 746
E+ R++ RQ +L Q+++
Sbjct: 1099 EKRRRQERERQCREEEELQQEEE 1121
Score = 36.2 bits (82), Expect = 0.16
Identities = 18/59 (30%), Positives = 36/59 (61%)
Query: 688 RREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
R E +L +REE+ +R+E R+ +++E + + Q + L + +R+QE K L+++Q
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397
Score = 36.2 bits (82), Expect = 0.16
Identities = 22/75 (29%), Positives = 44/75 (58%), Gaps = 3/75 (4%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQ-- 734
E+ L+ + Q R+ R +EE++ RR+E+ +Q++Q+ ++ +EEE+L + + +Q
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 735 -QELLLKLLQQQQAV 748
QE K ++Q V
Sbjct: 1574 RQERDRKFRLEEQKV 1588
Score = 35.8 bits (81), Expect = 0.21
Identities = 17/59 (28%), Positives = 39/59 (66%), Gaps = 1/59 (1%)
Query: 678 QLQLQHKFQERR-EVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
Q QL+ + R+ +V R +++E +R+R+E++ +++++E + + QEEE R++ +Q
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Score = 35.8 bits (81), Expect = 0.21
Identities = 24/81 (29%), Positives = 49/81 (60%), Gaps = 13/81 (16%)
Query: 676 LEQLQLQHKFQERR----EVELRAK------REEEERKRREEKRRQQQQEEQKRRQEEEE 725
LE+ +++ + QER+ E +LR + R+E +RK RE+++ Q++EEQ+ ++E +
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERD 1642
Query: 726 LFRRKHVRQQELLLKLLQQQQ 746
RK + ++ L + ++QQ
Sbjct: 1643 ---RKFLEEEPQLRRQEREQQ 1660
Score = 35.4 bits (80), Expect = 0.28
Identities = 23/70 (32%), Positives = 40/70 (57%), Gaps = 2/70 (2%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEEL-FRRKHVRQQE 736
Q Q + K ER L A+ E++ R+ + ++QQ EQ+ EEEE RR+ R++E
Sbjct: 770 QWQAEEK-SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 737 LLLKLLQQQQ 746
L+ L++++
Sbjct: 829 KELQFLEEEE 838
Score = 35.0 bits (79), Expect = 0.37
Identities = 20/59 (33%), Positives = 37/59 (62%), Gaps = 10/59 (16%)
Query: 678 QLQLQHKFQERREV-------ELRAKREEEERKRREE---KRRQQQQEEQKRRQEEEEL 726
Q + Q + ++ RE+ E + + E+ +R+RR+E ++RQ+ QE ++RR EEE+L
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQL 193
Score = 35.0 bits (79), Expect = 0.37
Identities = 26/80 (32%), Positives = 44/80 (55%), Gaps = 9/80 (11%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQK-RRQEEEELFRRKHV-- 732
L+ L+ + + Q R + + E+ ++ +E +R Q+Q+ +QK R Q EEE RR+H
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 733 ---RQQELLLK---LLQQQQ 746
QE L K LLQ+++
Sbjct: 891 AKPALQEQLRKEQQLLQEEE 910
Score = 34.7 bits (78), Expect = 0.48
Identities = 21/66 (31%), Positives = 38/66 (57%), Gaps = 6/66 (9%)
Query: 677 EQLQLQHK--FQERREVELRAKREEEERKR----REEKRRQQQQEEQKRRQEEEELFRRK 730
E+LQ + + +E RE R + E + RK+ +EE++ +++ E++R QE E +R +
Sbjct: 994 EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053
Query: 731 HVRQQE 736
QQE
Sbjct: 1054 EELQQE 1059
Score = 34.3 bits (77), Expect = 0.62
Identities = 66/297 (22%), Positives = 117/297 (39%), Gaps = 53/297 (17%)
Query: 58 EELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRG 117
+ L ++EF AVL+ P P ++ + E + + V+ L + K A +
Sbjct: 34 KNLLEREFGAVLR-RPHDPKTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQA 92
Query: 118 RG---STRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDG 174
G R+R G+ +S R EE F R+++ ++ G+RR +K ++
Sbjct: 93 TGLDEEKRARCDGK-ESLLQDRRQEEDQRRFEPRDRQLE-----EEPGQRRRQKRQEQER 146
Query: 175 ARCGFEEGGAGP----RKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSAS 230
EE +++ R D E WR +E QE EE R + ++ +S
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER---------RAEEEQLQSCK 197
Query: 231 PDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDG 290
G + + + + RR+ +LR G EE RR R F+E+++
Sbjct: 198 ---GHETEEFPDEEQLRRRELLELRRK----GREE------KQQQRRERQDRVFQEEEE- 243
Query: 291 LPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEE 347
EW + + + +E + EE+ + L+EEEE LE +
Sbjct: 244 -KEWRKRE---------------TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Score = 34.3 bits (77), Expect = 0.62
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 38/217 (17%)
Query: 159 DDRGERRFEKSARRDGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEE--EGSWRLG 216
D R + + + +++G R E+ R+E E R+ R++QEEE+ + +W+
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ 772
Query: 217 AGPRRDGDRWR-SASP---DGGPRSAGWREHGERRRKF-----EFDLRGDRGGCGEEEGR 267
A + + R R SA P + R E +R ++F E + R + E+E +
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ 832
Query: 268 GGGGSSHLRRCRAPEGFEEDKDGLPE-----------------WCLDDEDEEMGTFDASG 310
L+R + +E++DGL E W L++E +
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR------RR 886
Query: 311 AFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEE 347
L K +E + +EQ+L L+EEEE + E E
Sbjct: 887 HTLYAKPALQEQLRKEQQL----LQEEEEELQREERE 919
Score = 34.3 bits (77), Expect = 0.62
Identities = 20/59 (33%), Positives = 37/59 (62%), Gaps = 2/59 (3%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
+ L+ Q + ++ RE ELR +E+ RK EE++R ++QE +++ +EE+ R + QQ
Sbjct: 1351 QPLRRQERDRKFREEELR--HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Score = 33.9 bits (76), Expect = 0.82
Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 22/93 (23%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRR----------------------EEKRRQQQ 713
L++ Q + + QE+R + + EEERKRR EE+ Q+
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
+E +KRR++E+E R+ + Q+ +LL++++
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Score = 33.9 bits (76), Expect = 0.82
Identities = 18/70 (25%), Positives = 40/70 (57%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
E+ L+ + ++RR+ R REEEE +R++ K+R + ++++ + + E + VR +
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 737 LLLKLLQQQQ 746
+ K + +Q
Sbjct: 1240 VYCKGRENEQ 1249
Score = 33.5 bits (75), Expect = 1.1
Identities = 15/51 (29%), Positives = 32/51 (62%)
Query: 672 QGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQE 722
Q + + + Q + R+E E + +R E E + +EE+R +QQ+E+++R++
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Score = 33.1 bits (74), Expect = 1.4
Identities = 19/68 (27%), Positives = 41/68 (60%), Gaps = 7/68 (10%)
Query: 686 QERREVELRAKR-------EEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELL 738
QER E +LR ++ EEE+ + E+++R +Q+ +++ R EE+ + K R+++ L
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 739 LKLLQQQQ 746
+ +Q++
Sbjct: 1865 WQEEEQKR 1872
Score = 32.3 bits (72), Expect = 2.4
Identities = 18/63 (28%), Positives = 38/63 (60%), Gaps = 5/63 (7%)
Query: 689 REVELRAKREEEERKRREEKRRQQQQE-----EQKRRQEEEELFRRKHVRQQELLLKLLQ 743
+E L+ +R+EE+++R E + RQ ++E QKR+++E EL + +++ L+
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 744 QQQ 746
+Q+
Sbjct: 166 RQR 168
Score = 32.3 bits (72), Expect = 2.4
Identities = 21/70 (30%), Positives = 40/70 (57%), Gaps = 11/70 (15%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKR----REEKRRQQ----QQEEQKRRQ---EEEE 725
+QL + +ERR+ +LR +++E +R EE+R +Q + EE++R Q EEE+
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 726 LFRRKHVRQQ 735
R+ ++ +
Sbjct: 691 EQARERIKSR 700
Score = 32.0 bits (71), Expect = 3.1
Identities = 23/73 (31%), Positives = 37/73 (50%), Gaps = 6/73 (8%)
Query: 680 QLQHKFQERREVEL------RAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVR 733
Q Q + + RRE EL RA R+++E ++R + Q Q EE+ R + R
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 734 QQELLLKLLQQQQ 746
Q+E L+ ++QQ
Sbjct: 793 QRERQLRAEERQQ 805
Score = 30.8 bits (68), Expect = 6.9
Identities = 53/234 (22%), Positives = 85/234 (36%), Gaps = 54/234 (23%)
Query: 135 QRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFEEGGAGPRKEHARSD 194
+ +++ + R RE +R Q W ER++ K EE + R
Sbjct: 993 EEELQQEEEQLLREEREKRRRQEW----ERQYRKKDELQQ-----EEEQLLREEREKRRL 1043
Query: 195 SENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDL 254
E R REE+E ++E LG R R+ ER+ + E +L
Sbjct: 1044 QERERQYREEEELQQEEEQLLGE-----------------ERETRRRQELERQYRKEEEL 1086
Query: 255 RGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLP 314
+ + EE R+CR E +++++ L L +E E+
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL----LREEREKR----------- 1131
Query: 315 LKKGPKEPIPEEQELDFQGLEEEE---EPSEGLEEEGPEAGGKELTPLPPQEEK 365
QEL+ Q EEEE E + L EE + +EL +EE+
Sbjct: 1132 ----------RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 52.8 bits (125), Expect = 2e-06
Identities = 28/69 (40%), Positives = 47/69 (68%), Gaps = 1/69 (1%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
E + Q + Q RRE E + + EE ER+R+EE+ R ++ EE+KRR E E+ + R+ + +++
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEER-RRAEEEKRRVEREQEYIRRQLEEEQ 476
Query: 737 LLLKLLQQQ 745
L++LQQQ
Sbjct: 477 RHLEVLQQQ 485
Score = 51.6 bits (122), Expect = 4e-06
Identities = 25/71 (35%), Positives = 49/71 (69%), Gaps = 3/71 (4%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
LE+ Q + + R++ + +RE+EE++R EE R++++EE++RR EEE +R+ R+Q
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE---KRRVEREQ 465
Query: 736 ELLLKLLQQQQ 746
E + + L+++Q
Sbjct: 466 EYIRRQLEEEQ 476
Score = 46.6 bits (109), Expect = 1e-04
Identities = 41/133 (30%), Positives = 70/133 (52%), Gaps = 11/133 (8%)
Query: 677 EQLQLQHKFQERREVEL--RAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQ 734
E+ Q + + +E+R +E R ++EEEER+R EE++R+ ++E++ R++ EE R V Q
Sbjct: 424 EREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQ 483
Query: 735 QELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKT--LLELQLEGER---QLHKQP 789
Q+ LLQ+Q + A ++ L + LL LQ + R Q +QP
Sbjct: 484 QQ----LLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQP 539
Query: 790 PPREPARAQAPNH 802
PP + R++ H
Sbjct: 540 PPPQQERSKPSFH 552
Score = 46.2 bits (108), Expect = 2e-04
Identities = 34/102 (33%), Positives = 58/102 (56%), Gaps = 13/102 (12%)
Query: 655 QSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAK-------REEEERKRR-- 705
Q G +S+ ++P S+ + L +LQ + +ER E R + RE+EE KR+
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFL---RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL 392
Query: 706 -EEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E ++R +QQ+EQ+RR EE++ R+ RQQE + +Q++
Sbjct: 393 AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEE 434
Score = 37.0 bits (84), Expect = 0.096
Identities = 33/104 (31%), Positives = 49/104 (47%), Gaps = 20/104 (19%)
Query: 676 LEQLQLQHKFQERR---EVELRAKREEEE--RKRREEKRRQQQQEEQKRRQEEEELF--- 727
LE+L+ + K +E R E E R E+E R++ EE++R + +Q+ QE+ L
Sbjct: 438 LEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECR 497
Query: 728 --RRKHVRQQELLLKLLQQQQAV----------PVPPAPSSPPP 759
+ RQ E L + LQQ+QA P P PPP
Sbjct: 498 WREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPP 541
Score = 31.2 bits (69), Expect = 5.3
Identities = 24/97 (24%), Positives = 38/97 (39%), Gaps = 6/97 (6%)
Query: 324 PEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLPPQEEKSSSP------SPLPTLGP 377
P E+ Q + + E + ++ + E+ P P S SP SPL G
Sbjct: 664 PSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQ 723
Query: 378 LWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAG 414
G + T+ EP + + + PG GSS+G
Sbjct: 724 QNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 760
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/72 (40%), Positives = 50/72 (69%), Gaps = 6/72 (8%)
Query: 676 LEQLQLQHKFQERR-EVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQ 734
LE+ +L+ K +E R +E A+++EEERKR+EE++++Q+ EE+++ EE K +
Sbjct: 431 LEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKAGEE-----AKRKAE 485
Query: 735 QELLLKLLQQQQ 746
+ELLLK Q+Q+
Sbjct: 486 EELLLKEKQEQE 497
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/112 (28%), Positives = 61/112 (54%), Gaps = 12/112 (10%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
E+L+L+ +E R+ E KR+EEE+K++E + +++ EE KR+ EEE L + K ++++
Sbjct: 443 ERLRLE---EEARKQEEERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQ 499
Query: 737 LLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQ 788
+ +Q++A +A+Q + + LQ+E ER K+
Sbjct: 500 EKAMIEKQKEAAETKARE---------VAEQMRLEREQIMLQIEQERLERKK 542
Score = 41.6 bits (96), Expect = 0.004
Identities = 21/51 (41%), Positives = 35/51 (68%), Gaps = 1/51 (1%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
++RR+ L+ ++EE+ER +EE+ R ++EE KR+ EEE L + R+QE
Sbjct: 406 EKRRQARLQKEQEEQERVEKEEQDR-LEREELKRKAEEERLRLEEEARKQE 455
Score = 40.8 bits (94), Expect = 0.007
Identities = 27/70 (38%), Positives = 45/70 (64%), Gaps = 5/70 (7%)
Query: 675 ILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQ-QQQEEQKRRQEEEEL---FRRK 730
ILE+ Q + + Q +++E R ++ EE+R+R ++KR +++ +QK R+EEE L RR
Sbjct: 76 ILEK-QKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRS 134
Query: 731 HVRQQELLLK 740
R Q+L LK
Sbjct: 135 LERTQQLELK 144
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/60 (41%), Positives = 43/60 (71%), Gaps = 3/60 (5%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQ 745
Q+RRE ELR ++E E+R+ EE Q ++EE++RR E E+ + R+ + +++ L++LQQQ
Sbjct: 408 QQRREKELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ 464
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/70 (37%), Positives = 45/70 (64%), Gaps = 3/70 (4%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQ 746
+ + L+++Q
Sbjct: 446 YIRRQLEEEQ 455
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
Score = 41.2 bits (95), Expect = 0.005
Identities = 67/260 (25%), Positives = 109/260 (41%), Gaps = 51/260 (19%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEK---RRQQQQE------------------ 715
++L+ Q + ++RR E + +REEE R+ E+ RRQ ++E
Sbjct: 413 KELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALL 472
Query: 716 -EQKRRQEEE----ELFRRKHVRQQELLLKLL-QQQQAVPVPPAP---------SSPPPL 760
E KR+Q EE E +R+ ++++ L+ L Q+Q+ PV P S P
Sbjct: 473 LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPA 532
Query: 761 WAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPN---HRVQLGGLGTAPLNQW 817
WA +++K+ L + +H+QP +A N HRV++ + P
Sbjct: 533 WAKEIPHLVAVKS-QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDP---- 587
Query: 818 VSEAGPLWGGPDKSGGGSSGLGLWED----TPKSGGSLVRGLGLKNSRSSPSLSDSYSHL 873
SE PL +K SS L ED P+ S+ L KNS + S L
Sbjct: 588 TSENPPLPTRIEKF-DRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG--PRL 644
Query: 874 SGRPIRKKTEEEEKLLKLLQ 893
+PIR + + +L+
Sbjct: 645 GSQPIRASNPDLRRTEPILE 664
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/60 (41%), Positives = 43/60 (71%), Gaps = 3/60 (5%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQ 745
Q+RRE ELR ++E E+R+ EE Q ++EE++RR E E+ + R+ + +++ L++LQQQ
Sbjct: 408 QQRREKELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ 464
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/70 (37%), Positives = 45/70 (64%), Gaps = 3/70 (4%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQ 746
+ + L+++Q
Sbjct: 446 YIRRQLEEEQ 455
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
Score = 41.2 bits (95), Expect = 0.005
Identities = 67/260 (25%), Positives = 109/260 (41%), Gaps = 51/260 (19%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEK---RRQQQQE------------------ 715
++L+ Q + ++RR E + +REEE R+ E+ RRQ ++E
Sbjct: 413 KELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALL 472
Query: 716 -EQKRRQEEE----ELFRRKHVRQQELLLKLL-QQQQAVPVPPAP---------SSPPPL 760
E KR+Q EE E +R+ ++++ L+ L Q+Q+ PV P S P
Sbjct: 473 LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPA 532
Query: 761 WAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPN---HRVQLGGLGTAPLNQW 817
WA +++K+ L + +H+QP +A N HRV++ + P
Sbjct: 533 WAKEIPHLVAVKS-QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDP---- 587
Query: 818 VSEAGPLWGGPDKSGGGSSGLGLWED----TPKSGGSLVRGLGLKNSRSSPSLSDSYSHL 873
SE PL +K SS L ED P+ S+ L KNS + S L
Sbjct: 588 TSENPPLPTRIEKF-DRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG--PRL 644
Query: 874 SGRPIRKKTEEEEKLLKLLQ 893
+PIR + + +L+
Sbjct: 645 GSQPIRASNPDLRRTEPILE 664
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 52.0 bits (123), Expect = 3e-06
Identities = 38/119 (31%), Positives = 61/119 (51%), Gaps = 13/119 (10%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHV---RQQELLLKLL 742
Q+RRE ELR ++E E+R+ EE Q ++EE++RR E E+ ++RK + RQ E L + L
Sbjct: 408 QQRREKELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQL 464
Query: 743 QQQQAVPV-------PPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREP 794
+Q++ V P PL+ S K ++E +L++Q P P
Sbjct: 465 KQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMP 523
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 3/70 (4%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQ 746
K L++Q+
Sbjct: 446 YKRKQLEEQR 455
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 52.0 bits (123), Expect = 3e-06
Identities = 38/119 (31%), Positives = 61/119 (51%), Gaps = 13/119 (10%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHV---RQQELLLKLL 742
Q+RRE ELR ++E E+R+ EE Q ++EE++RR E E+ ++RK + RQ E L + L
Sbjct: 408 QQRREKELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQL 464
Query: 743 QQQQAVPV-------PPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREP 794
+Q++ V P PL+ S K ++E +L++Q P P
Sbjct: 465 KQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMP 523
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 3/70 (4%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQ 746
K L++Q+
Sbjct: 446 YKRKQLEEQR 455
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/60 (41%), Positives = 43/60 (71%), Gaps = 3/60 (5%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQ 745
Q+RRE ELR ++E E+R+ EE Q ++EE++RR E E+ + R+ + +++ L++LQQQ
Sbjct: 408 QQRREKELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ 464
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/70 (37%), Positives = 45/70 (64%), Gaps = 3/70 (4%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQ 746
+ + L+++Q
Sbjct: 446 YIRRQLEEEQ 455
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
Score = 38.9 bits (89), Expect = 0.025
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 30/144 (20%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKR--RQQQQEEQ----------------- 717
++L+ Q + ++RR E + +REEE R+ E+ R+Q +EEQ
Sbjct: 413 KELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALL 472
Query: 718 ---KRRQEEE----ELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLS 770
KR+Q EE E +R+ ++++ L+ L Q+Q P PL+ S
Sbjct: 473 LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ----EQRPVEKKPLYHYKEGMSPS 528
Query: 771 MKTLLELQLEGERQLHKQPPPREP 794
K ++E +L++Q P P
Sbjct: 529 EKPAWAKEVEERSRLNRQSSPAMP 552
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 52.0 bits (123), Expect = 3e-06
Identities = 25/60 (41%), Positives = 43/60 (71%), Gaps = 3/60 (5%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQ 745
Q+RRE ELR ++E E+R+ EE Q ++EE++RR E E+ + R+ + +++ L++LQQQ
Sbjct: 408 QQRREKELRKQQEREQRRHYEE---QMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQ 464
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/70 (37%), Positives = 45/70 (64%), Gaps = 3/70 (4%)
Query: 680 QLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEE---ELFRRKHVRQQE 736
QL + Q+R E + +R EE++RRE++ R+QQ+ EQ+R EE+ E RR+ +QE
Sbjct: 386 QLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQE 445
Query: 737 LLLKLLQQQQ 746
+ + L+++Q
Sbjct: 446 YIRRQLEEEQ 455
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/93 (34%), Positives = 58/93 (62%), Gaps = 6/93 (6%)
Query: 654 SQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQ 713
+ SG +S+ ++P S+ + L +LQL +K ER E LR ++ E++++ EE +RQ
Sbjct: 333 NDSGEPSSILNLPGESTLRRDFL-RLQLANK--ERSEA-LRRQQLEQQQRENEEHKRQLL 388
Query: 714 QEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQ 746
E QKR +E++E +R+ + +Q+ K L++QQ
Sbjct: 389 AERQKRIEEQKE--QRRRLEEQQRREKELRKQQ 419
Score = 38.9 bits (89), Expect = 0.025
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 30/144 (20%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKR--RQQQQEEQ----------------- 717
++L+ Q + ++RR E + +REEE R+ E+ R+Q +EEQ
Sbjct: 413 KELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALL 472
Query: 718 ---KRRQEEE----ELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLS 770
KR+Q EE E +R+ ++++ L+ L Q+Q P PL+ S
Sbjct: 473 LEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQ----EQRPVEKKPLYHYKEGMSPS 528
Query: 771 MKTLLELQLEGERQLHKQPPPREP 794
K ++E +L++Q P P
Sbjct: 529 EKPAWAKEVEERSRLNRQSSPAMP 552
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 51.6 bits (122), Expect = 4e-06
Identities = 89/367 (24%), Positives = 136/367 (37%), Gaps = 75/367 (20%)
Query: 40 RYGREEMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAV 99
R +EE Y +E + E+ + +E +L++ + A EEE R + V +
Sbjct: 796 RQRKEERRITYYREKEEEEQRRAEE--QMLKEREERERAERAKREEELREYQERVKKLEE 853
Query: 100 LRLMGKGAGPPLAGTSRGRGSTRSRGRG---RGDSCFYQRSIE-------EGDGAFGRSP 149
+ + + R R R G R DS + R E E D + R P
Sbjct: 854 VERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGP 913
Query: 150 --REIQRSQSWD-DRGERRFEKSARRDG----------------ARCGFEEGGAGPRK-- 188
+E +R + D DR RR E+ RR G R G ++ GPR+
Sbjct: 914 PEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDD-RGPRRGP 972
Query: 189 -------EHARSDSENWRSLREEQE-----EEEEGSWRLGAG---PRR--DGDR--WRSA 229
A D +WR+ +++ +E+ G+WR PRR D DR WR+A
Sbjct: 973 EEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTA 1032
Query: 230 SPDGGPRSAGWREHGERRR---------KFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRA 280
D GPR + G RR + D RG R G ++ G G R
Sbjct: 1033 DEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDD----RG 1088
Query: 281 PEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEP 340
P +D G DD G D G P + + IP +G E++ P
Sbjct: 1089 PRRGMDDDRGPRRGMDDDRGPRRGLDDDRG---PWRNADDDRIPR------RGAEDDRGP 1139
Query: 341 SEGLEEE 347
++++
Sbjct: 1140 WRNMDDD 1146
Score = 40.4 bits (93), Expect = 0.009
Identities = 28/99 (28%), Positives = 56/99 (56%), Gaps = 12/99 (12%)
Query: 649 HTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEK 708
H + S+ + L+ + + ++ Q E+L+ +F+ER E + EE +R+R+EE+
Sbjct: 746 HKNRMSRMLEDRDLFVMRLKAARQSVYEEKLK---QFEERLAEERHNRLEERKRQRKEER 802
Query: 709 R----RQQQQEEQKRRQEE-----EELFRRKHVRQQELL 738
R R++++EEQ+R +E+ EE R + +++E L
Sbjct: 803 RITYYREKEEEEQRRAEEQMLKEREERERAERAKREEEL 841
Score = 38.9 bits (89), Expect = 0.025
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 1/62 (1%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
LE+ + Q K +ERR R K EEE+R+ E+ +++++ E+ R + EE R R +
Sbjct: 791 LEERKRQRK-EERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVK 849
Query: 736 EL 737
+L
Sbjct: 850 KL 851
Score = 38.9 bits (89), Expect = 0.025
Identities = 22/53 (41%), Positives = 36/53 (67%), Gaps = 1/53 (1%)
Query: 684 KFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
K +E RE RAKREEE R+ +E+ ++ ++ E+K+RQ E E+ R+ R++E
Sbjct: 824 KEREERERAERAKREEELRE-YQERVKKLEEVERKKRQRELEIEERERRREEE 875
Score = 38.1 bits (87), Expect = 0.043
Identities = 22/61 (36%), Positives = 37/61 (60%), Gaps = 4/61 (6%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRR-QEEEELFRRKHVRQ 734
LE L +Q +E+ E+E R ++ RK EE+ RQ+ +E +K R +E E ++K VR+
Sbjct: 582 LESLNIQ---REKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRE 638
Query: 735 Q 735
+
Sbjct: 639 R 639
Score = 37.7 bits (86), Expect = 0.056
Identities = 19/53 (35%), Positives = 36/53 (67%), Gaps = 1/53 (1%)
Query: 686 QERREVELRAKREEEERKRREEKRRQQQ-QEEQKRRQEEEELFRRKHVRQQEL 737
+E+R E + +E EER+R E +R+++ +E Q+R ++ EE+ R+K R+ E+
Sbjct: 813 EEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEI 865
Score = 33.5 bits (75), Expect = 1.1
Identities = 22/67 (32%), Positives = 42/67 (62%), Gaps = 2/67 (2%)
Query: 675 ILEQLQLQHKFQERREVELRAKREEEERKRRE-EKRRQQQQEEQKRRQEEEELFRRKHVR 733
IL + Q + +ER E L +RE+EE ++RE E ++ ++ EE++ RQE +E + + ++
Sbjct: 568 ILARRQTIEERKERLE-SLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQ 626
Query: 734 QQELLLK 740
+ E + K
Sbjct: 627 EHEQIKK 633
Score = 33.5 bits (75), Expect = 1.1
Identities = 36/134 (26%), Positives = 49/134 (36%), Gaps = 21/134 (15%)
Query: 142 DGAFGRSPREIQRSQSW-----------DDRGERRFEKSARRDGARCGFEEGGAGPRKEH 190
+G + R P E S SW DDR R ++ R+ + GP
Sbjct: 1245 EGGWRRGPAE--ESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRS 1302
Query: 191 ARSDSENWRSL--REEQEEEEEGSWRLGAGP--RRDGDRWRSASPDGGPRSAGWREHGE- 245
R + +WR R++ EE R P RD +R R +G A WR +
Sbjct: 1303 EREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDR 1362
Query: 246 ---RRRKFEFDLRG 256
RR K E D G
Sbjct: 1363 ESLRRTKNETDEDG 1376
Score = 33.1 bits (74), Expect = 1.4
Identities = 46/198 (23%), Positives = 82/198 (41%), Gaps = 37/198 (18%)
Query: 696 KREEEERKRREEKRRQQQQEEQK----RRQEEEELFRRKHVRQQELLLKLLQQQQAVPVP 751
+R EER R E+R++Q++EE++ R +EEEE R +E +LK ++++
Sbjct: 781 ERLAEERHNRLEERKRQRKEERRITYYREKEEEE-----QRRAEEQMLKEREERER---- 831
Query: 752 PAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGGLGT 811
A AK+ ++ E +++ ++ ++ RE + R + LG
Sbjct: 832 ----------AERAKREEELREYQE-RVKKLEEVERKKRQRELEIEERERRREEERRLGD 880
Query: 812 APLNQWVSEAGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSPSLSDSYS 871
+ L++ S WG D G W P++ RG K R + S
Sbjct: 881 SSLSRKDSR----WGDRDSE-------GTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRS 929
Query: 872 HL--SGRPIRKKTEEEEK 887
H RP R +E+ +
Sbjct: 930 HRRDEERPRRLGDDEDRE 947
Score = 31.6 bits (70), Expect = 4.0
Identities = 21/54 (38%), Positives = 33/54 (61%), Gaps = 9/54 (16%)
Query: 677 EQLQLQHKFQERREVELR------AKREEEERKRREEKRRQQQQEEQKRRQEEE 724
E+ + + + +RE ELR K EE ERK+R+ R+ + EE++RR+EEE
Sbjct: 825 EREERERAERAKREEELREYQERVKKLEEVERKKRQ---RELEIEERERRREEE 875
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 18/142 (12%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKR--REEKRRQQQQEEQKRRQEEEELFRRKHV-- 732
EQ +LQ K Q+RR +++A R EEER++ RE++ +++Q EEQ++ + + +++H
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
Query: 733 -----RQQELLLKLLQQQQAVPVPPAP---------SSPPPLWAGLAKQGLSMKTLLELQ 778
+QQ+ L+ QQQQ +P P + P WA ++ M
Sbjct: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Query: 779 LEGERQLHKQPPPREPARAQAP 800
L + P P P + P
Sbjct: 537 LAKSKPGSTGPEPPIPQASPGP 558
Score = 49.7 bits (117), Expect = 1e-05
Identities = 27/80 (33%), Positives = 53/80 (66%), Gaps = 10/80 (12%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQ-------QQEEQKRRQEEEELFRRK 730
Q +++ + +ERR VE + +RE E+RK +E++++++ ++EE++R+ E E+ ++RK
Sbjct: 395 QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454
Query: 731 HV---RQQELLLKLLQQQQA 747
+ RQ E L + LQQ+ A
Sbjct: 455 QLEEQRQSERLQRQLQQEHA 474
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/71 (36%), Positives = 44/71 (61%), Gaps = 5/71 (7%)
Query: 681 LQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH-----VRQQ 735
L H+ Q R E + +R EE++RRE ++R+ Q++EQ+RR E+ + RR+ R+Q
Sbjct: 390 LLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 736 ELLLKLLQQQQ 746
E K L++Q+
Sbjct: 450 EYKRKQLEEQR 460
Score = 39.7 bits (91), Expect = 0.015
Identities = 19/79 (24%), Positives = 44/79 (55%)
Query: 668 NSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF 727
N S + +Q QLQ + Q E ++ + +R+ E+K +++ EEQ+RR+ E+
Sbjct: 362 NKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKL 421
Query: 728 RRKHVRQQELLLKLLQQQQ 746
+ K +++ ++ L++++
Sbjct: 422 QEKEQQRRLEDMQALRREE 440
Score = 31.6 bits (70), Expect = 4.0
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 547 DQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQ 606
D + L++++E A Q+ + +Q + S +L + +E A L L QQQQ
Sbjct: 432 DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL--------QQQQ 483
Query: 607 QQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPD 641
QQ QQ Q L P GD+ L R ++ D
Sbjct: 484 QQQQLQKQQQQQLLP---GDRKPLYHYGRGMNPAD 515
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 18/142 (12%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKR--REEKRRQQQQEEQKRRQEEEELFRRKHV-- 732
EQ +LQ K Q+RR +++A R EEER++ RE++ +++Q EEQ++ + + +++H
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
Query: 733 -----RQQELLLKLLQQQQAVPVPPAP---------SSPPPLWAGLAKQGLSMKTLLELQ 778
+QQ+ L+ QQQQ +P P + P WA ++ M
Sbjct: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Query: 779 LEGERQLHKQPPPREPARAQAP 800
L + P P P + P
Sbjct: 537 LAKSKPGSTGPEPPIPQASPGP 558
Score = 49.7 bits (117), Expect = 1e-05
Identities = 27/80 (33%), Positives = 53/80 (66%), Gaps = 10/80 (12%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQ-------QQEEQKRRQEEEELFRRK 730
Q +++ + +ERR VE + +RE E+RK +E++++++ ++EE++R+ E E+ ++RK
Sbjct: 395 QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454
Query: 731 HV---RQQELLLKLLQQQQA 747
+ RQ E L + LQQ+ A
Sbjct: 455 QLEEQRQSERLQRQLQQEHA 474
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/71 (36%), Positives = 44/71 (61%), Gaps = 5/71 (7%)
Query: 681 LQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH-----VRQQ 735
L H+ Q R E + +R EE++RRE ++R+ Q++EQ+RR E+ + RR+ R+Q
Sbjct: 390 LLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 736 ELLLKLLQQQQ 746
E K L++Q+
Sbjct: 450 EYKRKQLEEQR 460
Score = 39.7 bits (91), Expect = 0.015
Identities = 19/79 (24%), Positives = 44/79 (55%)
Query: 668 NSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF 727
N S + +Q QLQ + Q E ++ + +R+ E+K +++ EEQ+RR+ E+
Sbjct: 362 NKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKL 421
Query: 728 RRKHVRQQELLLKLLQQQQ 746
+ K +++ ++ L++++
Sbjct: 422 QEKEQQRRLEDMQALRREE 440
Score = 32.3 bits (72), Expect = 2.4
Identities = 88/393 (22%), Positives = 135/393 (34%), Gaps = 78/393 (19%)
Query: 547 DQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQ 606
D + L++++E A Q+ + +Q + S +L + +E A L L QQQQ
Sbjct: 432 DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL--------QQQQ 483
Query: 607 QQLTAFLQQLQALKPPRGGDQNLLPTMSRSLS----------VPDSGRLWDVHTSASSQS 656
QQ QQ Q L P GD+ L R ++ V + R+ S ++S
Sbjct: 484 QQQQLQKQQQQQLLP---GDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 657 GGEASLWDIPINSSTQGP--ILEQ---LQLQHKFQERREVELRAKREEEERKRREEKRRQ 711
++ + PI ++ GP L Q +Q + QE L A R + R Q
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 712 QQQEEQKRR-------QEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGL 764
Q++ R + + + Q P PS PP W
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWV-- 658
Query: 765 AKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPL 824
+ + PP+ P R + + G G + Q V + P
Sbjct: 659 -------------------RPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPD 699
Query: 825 WGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSR--------SSPSLS-------DS 869
D S + P S G L + L+ +R SSP LS D
Sbjct: 700 LRRSDPGWERSDSV-----LPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDD 754
Query: 870 YSHLSGRP--IRKKTEEEEKLLK--LLQGIPRP 898
+ GRP ++ E+ LLK L PRP
Sbjct: 755 HRSRPGRPASYKRAIGEDFVLLKERTLDEAPRP 787
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 18/142 (12%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKR--REEKRRQQQQEEQKRRQEEEELFRRKHV-- 732
EQ +LQ K Q+RR +++A R EEER++ RE++ +++Q EEQ++ + + +++H
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
Query: 733 -----RQQELLLKLLQQQQAVPVPPAP---------SSPPPLWAGLAKQGLSMKTLLELQ 778
+QQ+ L+ QQQQ +P P + P WA ++ M
Sbjct: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Query: 779 LEGERQLHKQPPPREPARAQAP 800
L + P P P + P
Sbjct: 537 LAKSKPGSTGPEPPIPQASPGP 558
Score = 49.7 bits (117), Expect = 1e-05
Identities = 27/80 (33%), Positives = 53/80 (66%), Gaps = 10/80 (12%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQ-------QQEEQKRRQEEEELFRRK 730
Q +++ + +ERR VE + +RE E+RK +E++++++ ++EE++R+ E E+ ++RK
Sbjct: 395 QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454
Query: 731 HV---RQQELLLKLLQQQQA 747
+ RQ E L + LQQ+ A
Sbjct: 455 QLEEQRQSERLQRQLQQEHA 474
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/71 (36%), Positives = 44/71 (61%), Gaps = 5/71 (7%)
Query: 681 LQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH-----VRQQ 735
L H+ Q R E + +R EE++RRE ++R+ Q++EQ+RR E+ + RR+ R+Q
Sbjct: 390 LLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 736 ELLLKLLQQQQ 746
E K L++Q+
Sbjct: 450 EYKRKQLEEQR 460
Score = 39.7 bits (91), Expect = 0.015
Identities = 19/79 (24%), Positives = 44/79 (55%)
Query: 668 NSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF 727
N S + +Q QLQ + Q E ++ + +R+ E+K +++ EEQ+RR+ E+
Sbjct: 362 NKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKL 421
Query: 728 RRKHVRQQELLLKLLQQQQ 746
+ K +++ ++ L++++
Sbjct: 422 QEKEQQRRLEDMQALRREE 440
Score = 31.6 bits (70), Expect = 4.0
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 547 DQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQ 606
D + L++++E A Q+ + +Q + S +L + +E A L L QQQQ
Sbjct: 432 DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL--------QQQQ 483
Query: 607 QQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPD 641
QQ QQ Q L P GD+ L R ++ D
Sbjct: 484 QQQQLQKQQQQQLLP---GDRKPLYHYGRGMNPAD 515
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/142 (27%), Positives = 67/142 (47%), Gaps = 18/142 (12%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKR--REEKRRQQQQEEQKRRQEEEELFRRKHV-- 732
EQ +LQ K Q+RR +++A R EEER++ RE++ +++Q EEQ++ + + +++H
Sbjct: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
Query: 733 -----RQQELLLKLLQQQQAVPVPPAP---------SSPPPLWAGLAKQGLSMKTLLELQ 778
+QQ+ L+ QQQQ +P P + P WA ++ M
Sbjct: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
Query: 779 LEGERQLHKQPPPREPARAQAP 800
L + P P P + P
Sbjct: 537 LAKSKPGSTGPEPPIPQASPGP 558
Score = 49.7 bits (117), Expect = 1e-05
Identities = 27/80 (33%), Positives = 53/80 (66%), Gaps = 10/80 (12%)
Query: 678 QLQLQHKFQERREVELRAKREEEERKRREEKRRQQ-------QQEEQKRRQEEEELFRRK 730
Q +++ + +ERR VE + +RE E+RK +E++++++ ++EE++R+ E E+ ++RK
Sbjct: 395 QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRK 454
Query: 731 HV---RQQELLLKLLQQQQA 747
+ RQ E L + LQQ+ A
Sbjct: 455 QLEEQRQSERLQRQLQQEHA 474
Score = 47.0 bits (110), Expect = 9e-05
Identities = 26/71 (36%), Positives = 44/71 (61%), Gaps = 5/71 (7%)
Query: 681 LQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKH-----VRQQ 735
L H+ Q R E + +R EE++RRE ++R+ Q++EQ+RR E+ + RR+ R+Q
Sbjct: 390 LLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQ 449
Query: 736 ELLLKLLQQQQ 746
E K L++Q+
Sbjct: 450 EYKRKQLEEQR 460
Score = 39.7 bits (91), Expect = 0.015
Identities = 19/79 (24%), Positives = 44/79 (55%)
Query: 668 NSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELF 727
N S + +Q QLQ + Q E ++ + +R+ E+K +++ EEQ+RR+ E+
Sbjct: 362 NKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKL 421
Query: 728 RRKHVRQQELLLKLLQQQQ 746
+ K +++ ++ L++++
Sbjct: 422 QEKEQQRRLEDMQALRREE 440
Score = 31.6 bits (70), Expect = 4.0
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 11/95 (11%)
Query: 547 DQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQ 606
D + L++++E A Q+ + +Q + S +L + +E A L L QQQQ
Sbjct: 432 DMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL--------QQQQ 483
Query: 607 QQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPD 641
QQ QQ Q L P GD+ L R ++ D
Sbjct: 484 QQQQLQKQQQQQLLP---GDRKPLYHYGRGMNPAD 515
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 51.2 bits (121), Expect = 5e-06
Identities = 26/66 (39%), Positives = 49/66 (74%), Gaps = 3/66 (4%)
Query: 682 QHKFQERREVELRAKREEEERKRREEKRRQQQQE--EQKRRQEEEELFRRKHVRQQELLL 739
+ + QERRE E R ++E E++RRE++RR+Q+++ EQ+RR+E+E L + ++++E L
Sbjct: 686 EQREQERREQE-RREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL 744
Query: 740 KLLQQQ 745
+L ++Q
Sbjct: 745 RLQKEQ 750
Score = 48.5 bits (114), Expect = 3e-05
Identities = 24/62 (38%), Positives = 44/62 (70%), Gaps = 1/62 (1%)
Query: 677 EQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQE 736
EQ +L+ + +R E R ++E E++RRE++RR+Q++ EQ+RR++E +L ++ R+QE
Sbjct: 671 EQERLRKAAEAKRLAEQR-EQERREQERREQERREQERREQERREQERQLAEQERRREQE 729
Query: 737 LL 738
L
Sbjct: 730 RL 731
Score = 45.1 bits (105), Expect = 4e-04
Identities = 28/68 (41%), Positives = 41/68 (60%), Gaps = 14/68 (20%)
Query: 681 LQHKFQERREVELRAKREEEERKR-------------REEKRRQQQQEEQKRR-QEEEEL 726
LQ + +ERR EL K++EEE++R RE++RR+Q++ EQ+RR QE E
Sbjct: 651 LQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ 710
Query: 727 FRRKHVRQ 734
RR+ RQ
Sbjct: 711 ERREQERQ 718
Score = 38.5 bits (88), Expect = 0.033
Identities = 33/122 (27%), Positives = 60/122 (49%), Gaps = 12/122 (9%)
Query: 677 EQLQLQHKFQERREVELRAKREEE----ERKRREEKRRQQQQEEQKRRQEEEELFRRKHV 732
E+ + + + QER+ E +RE+E ER+ +E ++ + Q+EQ +R+ EE ++K
Sbjct: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE---KKKKE 762
Query: 733 RQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPR 792
QQ L + LQ++Q A + L + Q + T ++ +G H+ PP
Sbjct: 763 EQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPAC-TSYQMTPQG----HRAPPKI 817
Query: 793 EP 794
P
Sbjct: 818 NP 819
Score = 37.7 bits (86), Expect = 0.056
Identities = 20/61 (32%), Positives = 38/61 (62%), Gaps = 1/61 (1%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
+E+++ + K QE LR ++EEE +R +E +++++EEQ+R ++ E R R+Q
Sbjct: 632 MEEVEARRK-QEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Query: 736 E 736
E
Sbjct: 691 E 691
Score = 36.6 bits (83), Expect = 0.13
Identities = 36/128 (28%), Positives = 61/128 (47%), Gaps = 10/128 (7%)
Query: 677 EQLQLQHKFQERREVELRAKREEE---ERKRREEKRRQQ--QQEEQKRRQEEEELFRRKH 731
E+ + + +E+ + + AK+ EE RK+ EE RR + QQEE++RR +EL ++K
Sbjct: 611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR--HQELLQKKK 668
Query: 732 VRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPP 791
+QE L K + ++ ++ + + + E ERQL +Q
Sbjct: 669 EEEQERLRKAAEAKRLAEQREQERREQ---ERREQERREQERREQERREQERQLAEQERR 725
Query: 792 REPARAQA 799
RE R QA
Sbjct: 726 REQERLQA 733
Score = 35.8 bits (81), Expect = 0.21
Identities = 19/53 (35%), Positives = 36/53 (67%), Gaps = 3/53 (5%)
Query: 699 EEERKRREEKRRQQQQEEQKRRQEEEELFRRKH---VRQQELLLKLLQQQQAV 748
E+ER+R E RR+++ E+ +R++ EE+ RR ++++E L K+LQ ++ V
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERV 588
Score = 35.4 bits (80), Expect = 0.28
Identities = 23/75 (30%), Positives = 41/75 (54%), Gaps = 8/75 (10%)
Query: 680 QLQHKFQERREVELRAKREE--EERKRREEKRRQQQQEEQKRRQEEEELFRR------KH 731
Q++ KF + E +AK E EE+ +++ ++ ++ E +R+QEEE R +
Sbjct: 598 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657
Query: 732 VRQQELLLKLLQQQQ 746
R QELL K +++Q
Sbjct: 658 RRHQELLQKKKEEEQ 672
Score = 34.7 bits (78), Expect = 0.48
Identities = 19/51 (37%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 677 EQLQLQ--HKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEE 725
EQL+ Q + + RR E++ KREE RK + + R +Q +E+K++Q E++
Sbjct: 552 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQK 602
Score = 31.6 bits (70), Expect = 4.0
Identities = 15/66 (22%), Positives = 42/66 (63%), Gaps = 1/66 (1%)
Query: 682 QHKFQERREVELR-AKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLK 740
Q K ++++++E + A+ +E+ K +EE+ +++ +++ ++ EE+ R+ ++ L+
Sbjct: 590 QMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Query: 741 LLQQQQ 746
LQQ++
Sbjct: 650 WLQQEE 655
Score = 30.4 bits (67), Expect = 9.0
Identities = 18/68 (26%), Positives = 39/68 (57%), Gaps = 4/68 (5%)
Query: 676 LEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQ 735
LE L+ + + ++ R R K EE++R+R EE + ++++ +K Q E + + K +++
Sbjct: 542 LENLRRKEEAEQLR----RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKK 597
Query: 736 ELLLKLLQ 743
++ K Q
Sbjct: 598 QIEQKFAQ 605
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,338,485
Number of Sequences: 37866
Number of extensions: 3254773
Number of successful extensions: 53653
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 565
Number of HSP's successfully gapped in prelim test: 872
Number of HSP's that attempted gapping in prelim test: 26013
Number of HSP's gapped (non-prelim): 16656
length of query: 1035
length of database: 18,247,518
effective HSP length: 112
effective length of query: 923
effective length of database: 14,006,526
effective search space: 12928023498
effective search space used: 12928023498
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.