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Search of human proteins with 91718899
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
(379 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 771 0.0
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 692 0.0
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 662 0.0
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 641 0.0
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 641 0.0
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 342 3e-94
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 342 3e-94
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 342 3e-94
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 324 7e-89
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 319 2e-87
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 317 9e-87
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 298 4e-81
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 285 4e-77
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 270 2e-72
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 268 6e-72
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 265 4e-71
gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens] 265 4e-71
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 263 1e-70
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 263 1e-70
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 263 3e-70
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 263 3e-70
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 263 3e-70
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 257 1e-68
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 257 1e-68
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 254 1e-67
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 254 1e-67
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 254 1e-67
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 254 1e-67
gi|149408126 nemo like kinase [Homo sapiens] 248 5e-66
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 248 6e-66
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 771 bits (1991), Expect = 0.0
Identities = 379/379 (100%), Positives = 379/379 (100%)
Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
Sbjct: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
Sbjct: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
Sbjct: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
Sbjct: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360
Query: 361 KELIFQETARFQPGVLEAP 379
KELIFQETARFQPGVLEAP
Sbjct: 361 KELIFQETARFQPGVLEAP 379
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 692 bits (1787), Expect = 0.0
Identities = 341/345 (98%), Positives = 342/345 (99%), Gaps = 1/345 (0%)
Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
Sbjct: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
Sbjct: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
Sbjct: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEP 345
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE V + P
Sbjct: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE-VGQSP 344
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 662 bits (1708), Expect = 0.0
Identities = 335/379 (88%), Positives = 335/379 (88%), Gaps = 44/379 (11%)
Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
Sbjct: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
Sbjct: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
NRPIFPGKHYLDQLNHIL
Sbjct: 241 NRPIFPGKHYLDQLNHIL------------------------------------------ 258
Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360
ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
Sbjct: 259 --ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 316
Query: 361 KELIFQETARFQPGVLEAP 379
KELIFQETARFQPGVLEAP
Sbjct: 317 KELIFQETARFQPGVLEAP 335
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 641 bits (1653), Expect = 0.0
Identities = 313/374 (83%), Positives = 334/374 (89%), Gaps = 17/374 (4%)
Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
MAAAAA G G EMV+GQ FDVGPRYT L YIGEGAYGMV SAY
Sbjct: 1 MAAAAAAGAGP-----------------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY 43
Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
D+V K RVAIKKISPFEHQTYCQRTLREI+ILLRFRHEN+IGI DI+RA T+E M+DVYI
Sbjct: 44 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI 103
Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
VQDLMETDLYKLLK+Q LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL+NTTCDL
Sbjct: 104 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
KICDFGLAR+ADP+HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 164 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN+KARNYL SLP K KV W +LFP +D
Sbjct: 224 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD 283
Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360
SKALDLLD+MLTFNP+KRI VE+ALAHPYLEQYYDP+DEP+AE PF F MELDDLPKE+L
Sbjct: 284 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL 343
Query: 361 KELIFQETARFQPG 374
KELIF+ETARFQPG
Sbjct: 344 KELIFEETARFQPG 357
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 641 bits (1653), Expect = 0.0
Identities = 313/374 (83%), Positives = 334/374 (89%), Gaps = 17/374 (4%)
Query: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
MAAAAA G G EMV+GQ FDVGPRYT L YIGEGAYGMV SAY
Sbjct: 1 MAAAAAAGAGP-----------------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY 43
Query: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
D+V K RVAIKKISPFEHQTYCQRTLREI+ILLRFRHEN+IGI DI+RA T+E M+DVYI
Sbjct: 44 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI 103
Query: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
VQDLMETDLYKLLK+Q LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL+NTTCDL
Sbjct: 104 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
Query: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
KICDFGLAR+ADP+HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 164 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
Query: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN+KARNYL SLP K KV W +LFP +D
Sbjct: 224 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD 283
Query: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360
SKALDLLD+MLTFNP+KRI VE+ALAHPYLEQYYDP+DEP+AE PF F MELDDLPKE+L
Sbjct: 284 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL 343
Query: 361 KELIFQETARFQPG 374
KELIF+ETARFQPG
Sbjct: 344 KELIFEETARFQPG 357
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 342 bits (877), Expect = 3e-94
Identities = 174/340 (51%), Positives = 238/340 (70%), Gaps = 4/340 (1%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 95 FRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILR 152
F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYR 211
GLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271
APE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS +
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331
+ + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF 371
+Y+DP DEP PF FA + + L +ER+KE I E F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 342 bits (877), Expect = 3e-94
Identities = 174/340 (51%), Positives = 238/340 (70%), Gaps = 4/340 (1%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 95 FRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILR 152
F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYR 211
GLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271
APE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS +
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331
+ + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF 371
+Y+DP DEP PF FA + + L +ER+KE I E F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 342 bits (877), Expect = 3e-94
Identities = 174/340 (51%), Positives = 238/340 (70%), Gaps = 4/340 (1%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
FDVG Y ++ IG GAYG+VSSA + +VAIKKI + F+ T +RTLRE++IL
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 95 FRHENVIGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILR 152
F+H+N+I I+DILR + + VY+V DLME+DL++++ S Q L+ +H+ YFLYQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 153 GLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYR 211
GLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 212 APEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 271
APE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS +
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 272 IINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLE 331
+ + R Y+QSLP + V W ++P +D +AL LL RML F P+ RI+ AL HP+L
Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLA 348
Query: 332 QYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARF 371
+Y+DP DEP PF FA + + L +ER+KE I E F
Sbjct: 349 KYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 324 bits (831), Expect = 7e-89
Identities = 169/344 (49%), Positives = 233/344 (67%), Gaps = 9/344 (2%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
+HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG
Sbjct: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP
Sbjct: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
+ ARNY+QSL K+ +A +F ++ A+DLL++ML + +KRIT +ALAH Y QY
Sbjct: 252 SESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311
Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 377
+DP DEPVA +P+ + E DL + K L + E F P L+
Sbjct: 312 HDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 319 bits (818), Expect = 2e-87
Identities = 165/344 (47%), Positives = 233/344 (67%), Gaps = 9/344 (2%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
+HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG
Sbjct: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP
Sbjct: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
EIMLN Y +++DIWSVGCI+AE+L+ R +FPG +++QL I+ + G+P +N +
Sbjct: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMP 251
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
+ +ARNY+QSL K+ +A +F ++ A+DLL++ML + +KRIT +ALAH Y QY
Sbjct: 252 SHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQY 311
Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLE 377
+DP DEPVA +P+ + E DL + K L + E F P L+
Sbjct: 312 HDPDDEPVA-DPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 354
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 317 bits (813), Expect = 9e-87
Identities = 162/340 (47%), Positives = 231/340 (67%), Gaps = 9/340 (2%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
++V R L+ +G GAYG V SAYD + +VA+KK+S PF+ + +RT RE+++L
Sbjct: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
+HENVIG+ D+ A+++E +VY+V LM DL ++K Q LS++H+ + +YQ+LRG
Sbjct: 78 LKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRG 137
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
LKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD E +T YVATRWYRAP
Sbjct: 138 LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAP 191
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
EIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++G+PS E L I
Sbjct: 192 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 251
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
+ AR Y+QSLP + + +F ++ A+DLL RML + ++R++ EALAH Y QY
Sbjct: 252 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 311
Query: 334 YDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373
+DP DEP A EP+ ++E + E KEL +QE F+P
Sbjct: 312 HDPEDEPEA-EPYDESVEAKERTLEEWKELTYQEVLSFKP 350
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 298 bits (764), Expect = 4e-81
Identities = 151/334 (45%), Positives = 219/334 (65%), Gaps = 9/334 (2%)
Query: 42 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 100
Y ++G GAYG V SA D +VAIKK+S PF+ + + +R RE+ +L +HENV
Sbjct: 25 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 84
Query: 101 IGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS 159
IG+ D+ AS+L D Y+V M+TDL K++ + S + I Y +YQ+L+GLKYIHS
Sbjct: 85 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-GMEFSEEKIQYLVYQMLKGLKYIHS 143
Query: 160 ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219
A V+HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAPE++L+
Sbjct: 144 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTRWYRAPEVILSW 197
Query: 220 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN 279
Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E + + + A++
Sbjct: 198 MHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 257
Query: 280 YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 339
Y+QSLP + + +LFP++ +A DLL++ML + +KR+T +AL HP+ E + DP +E
Sbjct: 258 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 317
Query: 340 PVAEEPFTFAMELDDLPKERLKELIFQETARFQP 373
A++PF ++E + L + K+ I++E F P
Sbjct: 318 TEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 285 bits (730), Expect = 4e-77
Identities = 146/342 (42%), Positives = 218/342 (63%), Gaps = 13/342 (3%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLR 94
++V Y LQ +G GAYG V SA D +VAIKK+ PF+ + + +R RE+++L
Sbjct: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
RHENVIG+ D+ TL+ D Y+V M TDL KL+K ++L D I + +YQ+L+G
Sbjct: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKG 140
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
L+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD E +T YV TRWYRAP
Sbjct: 141 LRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE------MTGYVVTRWYRAP 194
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+ + G+P E + +
Sbjct: 195 EVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQ 254
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQY 333
+ +A+NY++ LP K +A + + A++LL++ML + +R+T EALAHPY E
Sbjct: 255 SDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESL 314
Query: 334 YDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQETARFQP 373
+D DEP ++ + DD+ + + K + ++E F+P
Sbjct: 315 HDTEDEPQVQK---YDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 270 bits (690), Expect = 2e-72
Identities = 147/330 (44%), Positives = 211/330 (63%), Gaps = 12/330 (3%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
FD+G RY L+ +G G G+V SA D+ RVAIKKI + Q+ + LREI+I+ R
Sbjct: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
Query: 96 RHENVIGIRDILRAS---------TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYF 146
H+N++ + +IL S +L + VYIVQ+ METDL +L+ L +H F
Sbjct: 73 DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLF 132
Query: 147 LYQILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYV 205
+YQ+LRGLKYIHSANVLHRDLKP+NL INT LKI DFGLARI DP + H G L+E +
Sbjct: 133 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 192
Query: 206 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 265
T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL +
Sbjct: 193 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 252
Query: 266 QEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEAL 325
+ED ++++ Y+++ ++ +L P +ALD L+++LTF+P R+T EEAL
Sbjct: 253 EEDRQELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEAL 311
Query: 326 AHPYLEQYYDPTDEPVAEEPFTFAMELDDL 355
+HPY+ Y P DEP++ PF E+DD+
Sbjct: 312 SHPYMSIYSFPMDEPISSHPFHIEDEVDDI 341
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 268 bits (685), Expect = 6e-72
Identities = 130/249 (52%), Positives = 177/249 (71%), Gaps = 2/249 (0%)
Query: 125 METDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKIC 183
ME+DL++++ S Q L+ +H+ YFLYQ+LRGLKY+HSA V+HRDLKPSNLL+N C+LKI
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 184 DFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 242
DFG+AR + +H F+TEYVATRWYRAPE+ML+ YT++ID+WSVGCI EML+ R
Sbjct: 61 DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120
Query: 243 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK 302
+FPGK+Y+ QL I+ +LG+PS + + + R Y+QSLP + V W ++P +D +
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQ 180
Query: 303 ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKE 362
AL LL RML F P+ RI+ AL HP+L +Y+DP DEP PF FA + + L +ER+KE
Sbjct: 181 ALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKE 240
Query: 363 LIFQETARF 371
I E F
Sbjct: 241 AIVAEIEDF 249
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 265 bits (678), Expect = 4e-71
Identities = 135/263 (51%), Positives = 184/263 (69%), Gaps = 8/263 (3%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
+HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG
Sbjct: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP
Sbjct: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251
Query: 274 NMKARNYLQSLPSKTKVAWAKLF 296
+ ARNY+QSL K+ +A +F
Sbjct: 252 SESARNYIQSLTQMPKMNFANVF 274
>gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens]
Length = 587
Score = 265 bits (678), Expect = 4e-71
Identities = 141/333 (42%), Positives = 208/333 (62%), Gaps = 22/333 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
+D+G R+ Q +G G G+V SA D +VA+KKI+ + ++ + LREI+I+ R
Sbjct: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
Query: 96 RHENVIGIRDILRASTLEAMRDV------YIVQDLMETDLYKLLKSQQLSNDHICYFLYQ 149
H+N++ + ++L + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
Query: 150 ILRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATR 208
+LRGLKYIHSANVLHRDLKP+N+ I+T LKI DFGLARI D + H G+L+E + T+
Sbjct: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL + +ED
Sbjct: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
Query: 269 LNCIINMKARNYLQSLPSKTKVAW------AKLFPKSDSKALDLLDRMLTFNPNKRITVE 322
+ L+ +PS W KL P+ +S+A+D L+++LTFNP R+T E
Sbjct: 253 KD--------ELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAE 304
Query: 323 EALAHPYLEQYYDPTDEPVAEEPFTFAMELDDL 355
L HPY+ Y P DEP ++ PF E+DD+
Sbjct: 305 MGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDI 337
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 263 bits (673), Expect = 1e-70
Identities = 146/353 (41%), Positives = 224/353 (63%), Gaps = 24/353 (6%)
Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
+YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316
+ + RNY+++ P + + +LFP S+A DLL +ML +P+
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 263 bits (673), Expect = 1e-70
Identities = 146/353 (41%), Positives = 224/353 (63%), Gaps = 24/353 (6%)
Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
+YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316
+ + RNY+++ P + + +LFP S+A DLL +ML +P+
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 263 bits (671), Expect = 3e-70
Identities = 145/348 (41%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321
RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V
Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
++AL HPY+ +YDP E A P + +LD+ E KELI++E
Sbjct: 351 DDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 263 bits (671), Expect = 3e-70
Identities = 145/348 (41%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 58 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 117
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 118 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 176
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 177 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 232
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 233 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 290
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321
RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V
Sbjct: 291 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 350
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
++AL HPY+ +YDP E A P + +LD+ E KELI++E
Sbjct: 351 DDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 263 bits (671), Expect = 3e-70
Identities = 145/348 (41%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD V VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+I + ++ TLE +DVY+V +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPKS------------DSKALDLLDRMLTFNPNKRITV 321
RNY+++ P + + KLFP S S+A DLL +ML +P KRI+V
Sbjct: 253 QPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV 312
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
++AL HPY+ +YDP E A P + +LD+ E KELI++E
Sbjct: 313 DDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 359
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 257 bits (656), Expect = 1e-68
Identities = 142/348 (40%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321
R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
+EAL HPY+ +YDP+ E A P +LD+ E KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 257 bits (656), Expect = 1e-68
Identities = 142/348 (40%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321
R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
+EAL HPY+ +YDP+ E A P +LD+ E KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 254 bits (648), Expect = 1e-67
Identities = 142/348 (40%), Positives = 218/348 (62%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321
R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
+EAL HPY+ +YDP+ E A P +LD+ E KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 254 bits (648), Expect = 1e-67
Identities = 142/348 (40%), Positives = 218/348 (62%), Gaps = 24/348 (6%)
Query: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
F V RY L+ IG GA G+V +AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 95 FRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
H+N+IG+ ++ +LE +DVYIV +LM+ +L ++++ +L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-MELDHERMSYLLYQMLCG 138
Query: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273
E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 274 NMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPNKRITV 321
R Y+++ P ++ KLFP S+A DLL +ML + +KRI+V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 322 EEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
+EAL HPY+ +YDP+ E A P +LD+ E KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 254 bits (648), Expect = 1e-67
Identities = 143/353 (40%), Positives = 219/353 (62%), Gaps = 24/353 (6%)
Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316
+ + RNY+++ P + + +LFP S+A DLL +ML +P+
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 254 bits (648), Expect = 1e-67
Identities = 143/353 (40%), Positives = 219/353 (62%), Gaps = 24/353 (6%)
Query: 31 VKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREI 89
V F V RY QL+ IG GA G+V +A+D V VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 90 QILLRFRHENVIGIRDILRAS-TLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLY 148
+L H+N+I + ++ TLE +DVY+V +LM+ +L +++ +L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERMSYLLY 133
Query: 149 QILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATR 208
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 209 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 268
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
Query: 269 LNCIINMKARNYLQSLPSKTKVAWAKLFPK------------SDSKALDLLDRMLTFNPN 316
+ + RNY+++ P + + +LFP S+A DLL +ML +P+
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 317 KRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPK--ERLKELIFQE 367
KRI+V+EAL HPY+ +YDP E A P + +L++ E KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 248 bits (634), Expect = 5e-66
Identities = 141/350 (40%), Positives = 212/350 (60%), Gaps = 25/350 (7%)
Query: 48 IGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFRHENVIGIRDI 106
IG GA+G+V S D RVA+KK+ + F++ C+R RE+++L F+H+NV+ DI
Sbjct: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
Query: 107 LRASTLEAMRDVYIVQDLMETDLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANVLHR 165
L+ ++ ++Y+V +LM++DL+K++ S Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
Query: 166 DLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 225
D+KP NLL+N+ C LKICDFGLAR+ E D + +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 264 DIKPGNLLVNSNCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
Query: 226 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLP 285
IDIWSVGCI AE+L R +F + + QL+ I +LG+PS E + + L+
Sbjct: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPH 381
Query: 286 SKTKV-AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ------------ 332
+ + L ++ +A+ LL RML F+P+KRI+ ++ALAHPYL++
Sbjct: 382 KQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKC 441
Query: 333 --------YYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 374
Y EPV F E + ++KE+I Q Q G
Sbjct: 442 CFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKG 491
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 248 bits (633), Expect = 6e-66
Identities = 138/305 (45%), Positives = 195/305 (63%), Gaps = 9/305 (2%)
Query: 41 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-SPFEHQTYCQRTLREIQILLRFR-HE 98
RY + +G+GAYG+V A D VAIKKI F +T QRT REI +L F H
Sbjct: 12 RYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHP 71
Query: 99 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSND-HICYFLYQILRGLKYI 157
N+I + D++RA E RD+Y+V + M+TDL +++ L D H+ YQ+LR +++
Sbjct: 72 NIISLLDVIRA---ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
Query: 158 HSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IAD-PEHDHTGFLTEYVATRWYRAPEI 215
HS +V+HRD KPSN+L++ C +K+CDFGLAR + D PE +TEYVATRWYRAPE+
Sbjct: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEV 188
Query: 216 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 275
+L+S YT +D+WS+GCIL EML RP+FPG L QL IL + PS+EDL + +
Sbjct: 189 LLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSG 248
Query: 276 KARNYLQSLPSKTKVAWAKLFPKSDS-KALDLLDRMLTFNPNKRITVEEALAHPYLEQYY 334
+ L L S+ + L P S +ALDLL R+L F P+KR++ +AL HPY+++++
Sbjct: 249 CRASVLHQLGSRPRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFH 308
Query: 335 DPTDE 339
P+DE
Sbjct: 309 CPSDE 313
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,775,678
Number of Sequences: 37866
Number of extensions: 682194
Number of successful extensions: 4149
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 720
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 2026
Number of HSP's gapped (non-prelim): 1033
length of query: 379
length of database: 18,247,518
effective HSP length: 104
effective length of query: 275
effective length of database: 14,309,454
effective search space: 3935099850
effective search space used: 3935099850
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.