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Search of human proteins with 90991702
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens]
(2015 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens] 4071 0.0
gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens] 420 e-117
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 126 2e-28
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 108 7e-23
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 107 9e-23
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 107 1e-22
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 106 2e-22
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 105 4e-22
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 100 2e-20
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 97 1e-19
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 97 1e-19
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 97 1e-19
gi|238908508 leucine-rich repeat and death domain-containing pro... 96 4e-19
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 92 5e-18
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 92 5e-18
gi|45827729 scribble isoform b [Homo sapiens] 92 5e-18
gi|45827731 scribble isoform a [Homo sapiens] 92 5e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 92 7e-18
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 92 7e-18
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 89 3e-17
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 89 4e-17
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 89 4e-17
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 89 4e-17
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 89 4e-17
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 89 6e-17
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 89 6e-17
gi|4503787 fyn-related kinase [Homo sapiens] 87 2e-16
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 87 2e-16
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 87 2e-16
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 86 5e-16
>gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens]
Length = 2015
Score = 4071 bits (10558), Expect = 0.0
Identities = 2015/2015 (100%), Positives = 2015/2015 (100%)
Query: 1 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA 60
MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA
Sbjct: 1 MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRA 60
Query: 61 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD 120
AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD
Sbjct: 61 AYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTD 120
Query: 121 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP 180
DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP
Sbjct: 121 DNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADP 180
Query: 181 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF 240
ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF
Sbjct: 181 ESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYF 240
Query: 241 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG 300
IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG
Sbjct: 241 IEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWG 300
Query: 301 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS 360
LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS
Sbjct: 301 LINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTAS 360
Query: 361 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP 420
KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP
Sbjct: 361 KNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFP 420
Query: 421 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL 480
DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL
Sbjct: 421 DPWACPLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL 480
Query: 481 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL 540
QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL
Sbjct: 481 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL 540
Query: 541 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL 600
EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL
Sbjct: 541 EFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQL 600
Query: 601 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT 660
DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT
Sbjct: 601 DTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQT 660
Query: 661 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY 720
GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY
Sbjct: 661 GRAPQVVHGEATIRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALY 720
Query: 721 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA 780
VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA
Sbjct: 721 VVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLA 780
Query: 781 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG 840
LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG
Sbjct: 781 LCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAG 840
Query: 841 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL 900
RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL
Sbjct: 841 RLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFL 900
Query: 901 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG 960
IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG
Sbjct: 901 IETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVG 960
Query: 961 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM 1020
TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM
Sbjct: 961 TGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKM 1020
Query: 1021 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR 1080
SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR
Sbjct: 1021 SFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKR 1080
Query: 1081 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL 1140
NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL
Sbjct: 1081 NQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSL 1140
Query: 1141 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER 1200
IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER
Sbjct: 1141 IDQWFPALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIER 1200
Query: 1201 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA 1260
DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA
Sbjct: 1201 DFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRA 1260
Query: 1261 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV 1320
RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
Sbjct: 1261 RYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV 1320
Query: 1321 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK 1380
ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK
Sbjct: 1321 ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK 1380
Query: 1381 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV 1440
NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV
Sbjct: 1381 NIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIV 1440
Query: 1441 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM 1500
YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM
Sbjct: 1441 YDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMM 1500
Query: 1501 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR 1560
ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
Sbjct: 1501 ECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR 1560
Query: 1561 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA 1620
NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA
Sbjct: 1561 NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQQA 1620
Query: 1621 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS 1680
LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS
Sbjct: 1621 LDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANRSKFS 1680
Query: 1681 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV 1740
IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV
Sbjct: 1681 IADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPSMVTSVV 1740
Query: 1741 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS 1800
CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS
Sbjct: 1741 CSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPLDTEPPAAS 1800
Query: 1801 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP 1860
HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP
Sbjct: 1801 HTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPRQAARSPSSLP 1860
Query: 1861 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW 1920
SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW
Sbjct: 1861 SSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQAVKILAVRDLIW 1920
Query: 1921 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE 1980
VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE
Sbjct: 1921 VPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGVLVDAAVVAKDTVVCTFENENTE 1980
Query: 1981 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR 2015
WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR
Sbjct: 1981 WCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR 2015
>gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]
Length = 2527
Score = 420 bits (1080), Expect = e-117
Identities = 384/1439 (26%), Positives = 659/1439 (45%), Gaps = 210/1439 (14%)
Query: 280 ITELDLSANCLATLPSV-----IPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEI 334
IT LDLSAN L + ++ I L +L KL L N L P Q E + S L +
Sbjct: 984 ITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFP--QQLCETLKS-LTHL 1040
Query: 335 DISSNKLSHLPPGFLHLSKLQKLTASKNCL-----------------------EKLFEEE 371
D+ SNK + P L +S + L S+N + + F E
Sbjct: 1041 DLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPE 1100
Query: 372 NATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPW--ACP-LK 428
N T+ + KL++L + NK++ + + K L LN+S+N++ + + ACP ++
Sbjct: 1101 NLTDVV--EKLEQLILEGNKISGICSPL--RLKELKILNLSKNHISSLSENFLEACPKVE 1156
Query: 429 CCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAAL 488
A N L +P F + + S+N +P + L L L + N + L
Sbjct: 1157 SFSARMNFLAAMP-----FLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYL 1211
Query: 489 PPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFP--AFL 546
P W L+ L S NQ+ S+L+ A+L
Sbjct: 1212 PGPAHWKSLNLRELLFSHNQI----------------------------SILDLSEKAYL 1243
Query: 547 SESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLT 606
+E L L+ N L +PP + L++L+ L + N LR P E+G+L +W L ++L
Sbjct: 1244 WSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELH 1303
Query: 607 ISNVPAEIQKEGPKA--MLSYLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAP 664
++ + + G KA ++ +L+ +L+KA MK++IVG GK+TLL+ L +
Sbjct: 1304 LN---FDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKS 1360
Query: 665 QVVHGEAT--IRTTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVV 722
+ AT I W +Q + K + V NVWD G + + F T +ALY+
Sbjct: 1361 DLGMQSATVGIDVKDWPIQ--IRDKRKRDLV-LNVWDFAGREEFYSTHPHFMTQRALYLA 1417
Query: 723 VWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALC 782
V++L+ G+ V ++ WL NI+A+A ++ V++VGTHLD+ + K R ++ + +L
Sbjct: 1418 VYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELL--- 1474
Query: 783 RSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRL 842
GFP I H + +S + LR+ I + + + K I Q + G+L
Sbjct: 1475 ------NKRGFPAIRDYHFVNATEES-DALAKLRKTIINESLNFK-----IRDQLVVGQL 1522
Query: 843 IPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIK-DYEDLQSAISFLI 901
IP Y+ L++ +L+E R++ + + ++L QLV + N ++ D +L A+ FL
Sbjct: 1523 IPDCYVELEKIILSE--RKNVPIEFPVIDRKRLLQLVRE---NQLQLDENELPHAVHFLN 1577
Query: 902 ETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIK--GSRSVAKNGVIRAEDLRMLLV 959
E+G LLHF D + L +LYF++P WL + + +I +K G K + R + + L
Sbjct: 1578 ESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSK 1637
Query: 960 GTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPS-KPGLDTHGMRHPTANTIQRVF 1018
F + QYF+ L KF+IALP+ + L+P L +P ++ + + I R++
Sbjct: 1638 KRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCEN--SEIIIRLY 1695
Query: 1019 KMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRV 1078
+M + P+GFW R I R+L +++ Y +G +R
Sbjct: 1696 EMPYFPMGFWSRLINRLL----------------------EISPYMLSGRER-------A 1726
Query: 1079 KRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVN 1138
R +YW++G+ + + + S+V +S +KI S + + + DH++
Sbjct: 1727 LRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESF-LKITVPSCRKGCILLGQVVDHID 1785
Query: 1139 SLIDQWFPALTATE--SDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLT 1196
SL+++WFP L + +G L+++ WA ++ E+ Q ++D +
Sbjct: 1786 SLMEEWFPGLLEIDICGEGETLLKK----------WALYS--FNDGEEHQKILLDDLMKK 1833
Query: 1197 AIERDFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTV 1256
A E D + P P L +P+ ++ P+L + D P + L N +LE + +LG G G+V
Sbjct: 1834 AEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSV 1893
Query: 1257 IYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQH 1316
YRA Y+G+ VAVK F+ T LR LR QE +L L H
Sbjct: 1894 -YRAAYEGEEVAVKIFN-----------KHTSLRLLR------------QELVVLCHLHH 1929
Query: 1317 PCIVALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAY 1376
P +++L+ I P +ELA SL+ +L ++ L L +IA +A GL Y
Sbjct: 1930 PSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKAS-----LTRTLQHRIALHVADGLRY 1984
Query: 1377 LHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEI- 1435
LH II+ DLK N+L+++L I K++DYGI++ G EGTPG++APE+
Sbjct: 1985 LHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVA 2044
Query: 1436 RPRIVYDEKVDMFSYGMVLYELL-SGQRPALG------HHQLQIAKKLSKGIRPVLGQPE 1488
R ++Y+++ D++S+G++LY++L +G R G +L+I KL ++ P
Sbjct: 2045 RGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAP- 2103
Query: 1489 EVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQT---AFFSSQG 1545
+ ++ L+ +C P++RP + V + + K ++
Sbjct: 2104 ---WPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHH 2160
Query: 1546 QEYTVVFWDG----KEESRNYTVVNTEKGLMEV---QRMCCPGMKVSCQLQVQRSLW--T 1596
W G ++ +NTE E R+ C + L V++ W +
Sbjct: 2161 NSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLAL---VHLPVEKESWIVS 2217
Query: 1597 ATEDQKIYIYTLKGMCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVF 1655
T+ + + + +T ++ D+ + C K+ ++L L G ADG +A+F
Sbjct: 2218 GTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFL-LVGTADGKLAIF 2275
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 126 bits (316), Expect = 2e-28
Identities = 186/698 (26%), Positives = 285/698 (40%), Gaps = 108/698 (15%)
Query: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSN 339
I L+L N L +P + L +LR L L N LP + + L E+D+S N
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAE---LGHHLTELDVSHN 121
Query: 340 KLSHLPPGFLH-LSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPAL 398
+L+ L + L +L+KL S N L L + A L L+ELD+S N+L LP
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGA-----LAHLEELDVSFNRLAHLPDS 176
Query: 399 FLHSFKSLNSLNVSRNNLKVFPDPWA--CPLKCCKASRNALECLPDKMAVFWKNHLKDVD 456
L L +L+V N L FP L+ S N L LP+ ++ LK +
Sbjct: 177 -LSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISAL--RALKILW 233
Query: 457 FSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQ-LKTLDLSRNQLGKNEDG 515
S L +P G +L +L L L N L ALP Q ++C Q LK L+LS N +
Sbjct: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQALPAQ--FSCLQRLKMLNLSSNLFEEFP-- 289
Query: 516 LKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSE--SLEVLCLNDNHLDTVPPSVCLLKSL 573
A G + + P+ +S L L L++N + +P S+ L L
Sbjct: 290 -----AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
Query: 574 SELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLR--AQLR 631
EL L N + LP GQL + +D + P E+ +G + +Y + A +
Sbjct: 345 EELVLQGNQ-IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQ 403
Query: 632 KAEKCKLMKMIIVGPPRQGKSTLLEILQTGRA-----------------PQVVHGEATIR 674
A + +L K++++G GK+ L L R P V G I
Sbjct: 404 PAVQPRL-KLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKG---IE 459
Query: 675 TTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGE--EA 732
T W G R F V+D+ G S + F + ALYV+V NLA E
Sbjct: 460 VTSWTADASRGLR-------FIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHF 512
Query: 733 VANLQFWLLNIEAKAPNAVVLVVGTHLDL------------------IEAKFRVERIATL 774
+ +L + A+ P+AVV +VGTH DL ++ K E ++ L
Sbjct: 513 PTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSRL 572
Query: 775 RAYV-LALCRSPSGSRATGFPDITFKHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTI 833
V AL R A+ P + + +S K+L ++ Q + + + +
Sbjct: 573 AKVVDEALARDFELRSAS--PHAAY---YGVSDKNLRRRKAHFQYLLNHRLQILSPVLPV 627
Query: 834 GCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQ---LEQLVEQTPDNDI--- 887
C+ PR L++ +L+ + R ++ + R LE+L Q P
Sbjct: 628 SCRD------PRHLRRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWL 681
Query: 888 -------------KDYEDLQSAISFLIETGTLLHFPDT 912
+ LQSA+S+L E+G LL+F D+
Sbjct: 682 SWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDS 719
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 108 bits (269), Expect = 7e-23
Identities = 91/288 (31%), Positives = 136/288 (47%), Gaps = 47/288 (16%)
Query: 1247 VLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQ 1306
++G GG G V YRA + G VAVK RH D + RQ
Sbjct: 149 IIGIGGFGKV-YRAFWIGDEVAVKA-----------------ARHDPDEDISQTIENVRQ 190
Query: 1307 EASMLHALQHPCIVALIGISIHP--LCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQ 1364
EA + L+HP I+AL G+ + LC +E A LN VLS IP ++
Sbjct: 191 EAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR-----IPPDILVNW 245
Query: 1365 KIAYQIASGLAYLHKKNI---IFCDLKSDNILVWSL----DVKEHINIKLSDYGISRQSF 1417
A QIA G+ YLH + I I DLKS NIL+ D+ I +K++D+G++R+
Sbjct: 246 --AVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKI-LKITDFGLAREWH 302
Query: 1418 HEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIA---- 1473
+ GT + APE+ ++ + D++SYG++L+ELL+G+ P G L +A
Sbjct: 303 RTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVA 362
Query: 1474 -KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQM 1520
KL+ I +P LM +CW+ P RP +++ Q+
Sbjct: 363 MNKLALPIPSTCPEP-------FAKLMEDCWNPDPHSRPSFTNILDQL 403
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 107 bits (268), Expect = 9e-23
Identities = 95/298 (31%), Positives = 140/298 (46%), Gaps = 52/298 (17%)
Query: 1247 VLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQ 1306
++G GG G V YRA +QGQ VAVK R DA R+
Sbjct: 129 LIGAGGFGQV-YRATWQGQEVAVKA-----------------ARQDPEQDAAAAAESVRR 170
Query: 1307 EASMLHALQHPCIVALIGISIHP--LCFALELAPLSSLNTVLSE-NARDSSFIPLGHMLT 1363
EA + L+HP I+ L G+ + LC LE A +LN L+ NA P G
Sbjct: 171 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAP-GPRRA 229
Query: 1364 QKI--------AYQIASGLAYLHKKN---IIFCDLKSDNILVWSLDVKEHINI-----KL 1407
++I A QIA G+ YLH++ I+ DLKS NIL+ L+ EH +I K+
Sbjct: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILL--LEKIEHDDICNKTLKI 287
Query: 1408 SDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGH 1467
+D+G++R+ + GT + APE+ ++ + D++SYG++L+ELL+G+ P G
Sbjct: 288 TDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGI 347
Query: 1468 HQLQIA-----KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQM 1520
L +A KL+ I +P LM ECW P RP ++ Q+
Sbjct: 348 DGLAVAYGVAVNKLTLPIPSTCPEP-------FAKLMKECWQQDPHIRPSFALILEQL 398
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 107 bits (267), Expect = 1e-22
Identities = 103/355 (29%), Positives = 163/355 (45%), Gaps = 45/355 (12%)
Query: 279 QITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISS 338
QIT LDL N L LP I L +L +L L N L +P + CS L E+++ +
Sbjct: 262 QITNLDLQHNELLDLPDTIG-NLSSLSRLGLRYNRLSAIPRSLAK----CSALEELNLEN 316
Query: 339 NKLSHLPPGFLH-LSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPA 397
N +S LP L L KL LT ++NC + L+ + + + L++ N++ ++P
Sbjct: 317 NNISTLPESLLSSLVKLNSLTLARNCFQ-LYPVGGPSQF---STIYSLNMEHNRINKIPF 372
Query: 398 LFLHSFKSLNSLNVSRNNLKVFP---DPWACPLKCCKASRNALECLPDKMAVFWKNHLKD 454
K L+ LN+ N L P W ++ A+ N L +P+ ++ L+
Sbjct: 373 GIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLAT-NQLTKIPEDVSGLVS--LEV 429
Query: 455 VDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNED 514
+ S N LK++P GL L L L L+ N+L +LP + + + L+ L L+ NQL
Sbjct: 430 LILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYL-KDLQKLVLTNNQLTTLPR 488
Query: 515 GLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLS 574
G I T +L L L +N L +P + L++L
Sbjct: 489 G-----IGHLT-----------------------NLTHLGLGENLLTHLPEEIGTLENLE 520
Query: 575 ELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQ 629
ELYL +NP L LP EL L + E+ +S++P +I GP ++ +L+ Q
Sbjct: 521 ELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQ 575
Score = 88.2 bits (217), Expect = 7e-17
Identities = 105/360 (29%), Positives = 161/360 (44%), Gaps = 40/360 (11%)
Query: 279 QITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISS 338
Q+TEL L +N L +LP+ + L+NL L LS+N L LP S D + +L +D+
Sbjct: 124 QLTELYLYSNKLQSLPAEVGC-LVNLMTLALSENSLTSLP--DSLDNL--KKLRMLDLRH 178
Query: 339 NKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPAL 398
NKL +P L L L N + + E++ N L KL L I +NK+ +LPA
Sbjct: 179 NKLREIPSVVYRLDSLTTLYLRFNRITTV--EKDIKN---LSKLSMLSIRENKIKQLPA- 232
Query: 399 FLHSFKSLNSLNVSRNNLKVFPDPW--ACPLKCCKASRNALECLPDKMAVFWKNHLKDVD 456
+ +L +L+V+ N L+ P + N L LPD + + L +
Sbjct: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL--SSLSRLG 290
Query: 457 FSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRN--QL----- 509
N L +P L + AL L L+ N ++ LP + +L +L L+RN QL
Sbjct: 291 LRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGG 350
Query: 510 --------GKNEDGLKTKRIAF-------FTTRGRQRSGTEAASVLEFPAFLSESLEVLC 554
N + + +I F ++ + + L+F + S+ L
Sbjct: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTW--TSMVELN 408
Query: 555 LNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
L N L +P V L SL L L NN L++LP LG L L +LD E+ + ++P EI
Sbjct: 409 LATNQLTKIPEDVSGLVSLEVLILSNNL-LKKLPHGLGNLRKLRELDLEENKLESLPNEI 467
Score = 65.5 bits (158), Expect = 5e-10
Identities = 66/247 (26%), Positives = 110/247 (44%), Gaps = 41/247 (16%)
Query: 273 LIDISCQITELDLSANCLATLP--------------------SVIPWGLIN----LRKLN 308
L+ ++ L L+ NC P + IP+G+ + L KLN
Sbjct: 326 LLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLN 385
Query: 309 LSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLF 368
+ DN L LP D + ++E+++++N+L+ +P L L+ L S N L+KL
Sbjct: 386 MKDNQLTSLP----LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL- 440
Query: 369 EEENATNWIG-LRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPD--PWAC 425
+ +G LRKL+ELD+ +NKL LP + K L L ++ N L P
Sbjct: 441 -----PHGLGNLRKLRELDLEENKLESLPNEIAY-LKDLQKLVLTNNQLTTLPRGIGHLT 494
Query: 426 PLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENA-LKEVPLGLFQLDALMFLRLQGNQ 484
L N L LP+++ +L+++ ++N L +P L L + ++
Sbjct: 495 NLTHLGLGENLLTHLPEEIGTL--ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCP 552
Query: 485 LAALPPQ 491
L+ LPPQ
Sbjct: 553 LSHLPPQ 559
Score = 53.1 bits (126), Expect = 3e-06
Identities = 66/257 (25%), Positives = 108/257 (42%), Gaps = 30/257 (11%)
Query: 364 LEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPW 423
L K EE + + R + L S +LT+L L+L+S N L+ P
Sbjct: 94 LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYS-----------NKLQSLPAEV 142
Query: 424 AC--PLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQ 481
C L S N+L LPD + K L+ +D N L+E+P +++LD+L L L+
Sbjct: 143 GCLVNLMTLALSENSLTSLPDSLDNLKK--LRMLDLRHNKLREIPSVVYRLDSLTTLYLR 200
Query: 482 GNQLAALPPQEKWTCRQLKTLDLSRNQLGK--NEDGLKTKRIAFFTTRGRQRSGTEAASV 539
N++ + K +L L + N++ + E G I + +
Sbjct: 201 FNRITTVEKDIK-NLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQ---------L 250
Query: 540 LEFPAFLSESLEV--LCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNL 597
P + ++ L L N L +P ++ L SLS L L N L +P L + L
Sbjct: 251 EHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYN-RLSAIPRSLAKCSAL 309
Query: 598 WQLDTEDLTISNVPAEI 614
+L+ E+ IS +P +
Sbjct: 310 EELNLENNNISTLPESL 326
Score = 39.7 bits (91), Expect = 0.030
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 1/105 (0%)
Query: 528 GRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLREL 587
G ++ + A + E E+ L L+ + +P S+ L L+ELYL +N L+ L
Sbjct: 80 GTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNK-LQSL 138
Query: 588 PPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRK 632
P E+G L NL L + +++++P + ML +LR+
Sbjct: 139 PAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLRE 183
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 106 bits (265), Expect = 2e-22
Identities = 99/309 (32%), Positives = 152/309 (49%), Gaps = 49/309 (15%)
Query: 1228 PARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADT 1287
PA L L H ++G GG G V YRA ++G+ VAVK + K+ PA T
Sbjct: 84 PAGLQLPQEIPFHELQLEEIIGVGGFGKV-YRALWRGEEVAVKAARLDPEKD----PAVT 138
Query: 1288 MLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHP--LCFALELAPLSSLNTV 1345
+ QEA + ALQHP I+AL G ++P LC +E A +L+ V
Sbjct: 139 A-------------EQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRV 185
Query: 1346 LSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKN---IIFCDLKSDNILVWSLDVKEH 1402
L+ +P H+L A Q+A G+ YLH II DLKS NIL+ L+ E+
Sbjct: 186 LAGRR-----VP-PHVLVNW-AVQVARGMNYLHNDAPVPIIHRDLKSINILI--LEAIEN 236
Query: 1403 INI-----KLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYEL 1457
N+ K++D+G++R+ + GT + APE+ ++ + D++S+G++L+EL
Sbjct: 237 HNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWEL 296
Query: 1458 LSGQRPALGHHQLQIA-----KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPL 1512
L+G+ P L +A KL+ I +P F R L+ ECWD P RP
Sbjct: 297 LTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEP----FAR---LLEECWDPDPHGRPD 349
Query: 1513 ALSVVSQMK 1521
S++ +++
Sbjct: 350 FGSILKRLE 358
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 105 bits (262), Expect = 4e-22
Identities = 108/364 (29%), Positives = 164/364 (45%), Gaps = 49/364 (13%)
Query: 297 IPWGLINLRK----LNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPG----F 348
+P GL+ + LNLS +L E+P C + +DI +L G +
Sbjct: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQ--------CVWRINVDIPEEANQNLSFGATERW 78
Query: 349 LHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNS 408
+ L KL S N L+ L ++ L L LDI DN+LT LP+ + ++L
Sbjct: 79 WEQTDLTKLIISNNKLQSLTDDLRL-----LPALTVLDIHDNQLTSLPSA-IRELENLQK 132
Query: 409 LNVSRNNLKVFPDPWAC--PLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVP 466
LNVS N LK+ P+ LKC N L C+ + ++L+D+D S N L VP
Sbjct: 133 LNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQL--SNLEDLDLSNNHLTTVP 190
Query: 467 LGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQL---GKNEDGLKTKRIAF 523
L +L+ L L N+L +LP + ++LK LD + N L G+++ +
Sbjct: 191 ASFSSLSSLVRLNLSSNELKSLPAEIN-RMKRLKHLDCNSNLLETIPPELAGMESLEL-L 248
Query: 524 FTTRGRQR---------------SGTEAASVLEFPAFLS-ESLEVLCLNDNHLDTVPPSV 567
+ R + R G +LE S+ VL L DN L +VP +
Sbjct: 249 YLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI 308
Query: 568 CLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLR 627
LL+SL L L NN + LP LG L +L L E + + EI +G + +L YLR
Sbjct: 309 ILLRSLERLDLSNN-DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLR 366
Query: 628 AQLR 631
++++
Sbjct: 367 SKIK 370
Score = 80.5 bits (197), Expect = 2e-14
Identities = 74/230 (32%), Positives = 113/230 (49%), Gaps = 28/230 (12%)
Query: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSS-----------DEIIC 328
+T LD+ N L +LPS I L NL+KLN+S N L LP ++ +E+ C
Sbjct: 107 LTVLDIHDNQLTSLPSAIR-ELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTC 165
Query: 329 --------SRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLR 380
S L ++D+S+N L+ +P F LS L +L S N L+ L E N ++
Sbjct: 166 ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR-----MK 220
Query: 381 KLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACP-LKCCKASRNALEC 439
+L+ LD + N L +P L +SL L + RN L+ P+ +C LK N +E
Sbjct: 221 RLKHLDCNSNLLETIPP-ELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEM 279
Query: 440 LPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALP 489
L + + N + +D +N LK VP + L +L L L N +++LP
Sbjct: 280 L-EAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328
Score = 72.8 bits (177), Expect = 3e-12
Identities = 102/374 (27%), Positives = 163/374 (43%), Gaps = 56/374 (14%)
Query: 277 SCQIT-ELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLE-I 334
SC + EL + N + L + L ++ L+L DN L +P DEII R LE +
Sbjct: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVP-----DEIILLRSLERL 317
Query: 335 DISSNKLSHLPP--GFLHLSKL----------QKLTASKNCLEKLFEEENATNWIGLRKL 382
D+S+N +S LP G LHL L ++ SK E L + G +
Sbjct: 318 DLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQS 377
Query: 383 QELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKC-----CKASRNAL 437
+ + L + +H+ +L L+ S + PD +K S+N L
Sbjct: 378 ESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQL 437
Query: 438 ECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCR 497
+P +M V K + DVD S N L + L L L L FL L+ N L +LP +E +
Sbjct: 438 CEIPKRM-VELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLP-EEMESLV 495
Query: 498 QLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLND 557
+L+T++LS N+ +L + +LE + +++
Sbjct: 496 RLQTINLSFNRF----------------------------KMLPEVLYRIFTLETILISN 527
Query: 558 NHLDTVPPS-VCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQK 616
N + +V P + ++++L+ L L NN L ++PPELG NL L + A I
Sbjct: 528 NQVGSVDPQKMKMMENLTTLDLQNND-LLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM 586
Query: 617 EGPKAMLSYLRAQL 630
+G A+L YLR ++
Sbjct: 587 KGTAAILEYLRDRI 600
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 100 bits (248), Expect = 2e-20
Identities = 87/288 (30%), Positives = 134/288 (46%), Gaps = 45/288 (15%)
Query: 1247 VLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQ 1306
V+G GG G V YR ++G+ VAVK R D RQ
Sbjct: 122 VIGIGGFGKV-YRGSWRGELVAVKA-----------------ARQDPDEDISVTAESVRQ 163
Query: 1307 EASMLHALQHPCIVALIGISIHP--LCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQ 1364
EA + L HP I+AL + + LC +E A L+ L+ +P H+L
Sbjct: 164 EARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR-----VP-PHVLVN 217
Query: 1365 KIAYQIASGLAYLHKKN---IIFCDLKSDNILVWS---LDVKEHINIKLSDYGISRQSFH 1418
A QIA G+ YLH + +I DLKS+NIL+ D EH +K++D+G++R+
Sbjct: 218 W-AVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHK 276
Query: 1419 EGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIA----- 1473
+ GT + APE+ + + D++S+G++L+ELL+G+ P G L +A
Sbjct: 277 TTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAV 336
Query: 1474 KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMK 1521
KL+ I +P LM +CW P +RP S++ Q++
Sbjct: 337 NKLTLPIPSTCPEP-------FAQLMADCWAQDPHRRPDFASILQQLE 377
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 97.4 bits (241), Expect = 1e-19
Identities = 83/313 (26%), Positives = 144/313 (46%), Gaps = 46/313 (14%)
Query: 1221 ELFMTDFPARLFLENSKLEHSED----EGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKK 1276
E F+ ++F ENS L+ E +G +LG+G GTV QGQ +AVK+ +
Sbjct: 1037 EKFLISNEKKIFSENS-LKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDT 1095
Query: 1277 FKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISI--HPLCFAL 1334
A A K + + ++E +L AL+H IVA +G + + + +
Sbjct: 1096 SNKLA---------------AEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFM 1140
Query: 1335 ELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILV 1394
E P S++++++ F PL M+ K QI G+AYLH+ ++ D+K +N+++
Sbjct: 1141 EFVPGGSISSIINR------FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVML 1194
Query: 1395 WSLDVKEHINIKLSDYGISRQSFHEGALG--------VEGTPGYQAPEIRPRIVYDEKVD 1446
+ IKL D+G +R+ G G + GTP + APE+ Y K D
Sbjct: 1195 MPTGI-----IKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSD 1249
Query: 1447 MFSYGMVLYELLSGQRPALGHHQLQIAKKLS--KGIRPVLGQPEEVQFRRLQALMMECWD 1504
++S G ++E+ +G+ P ++ + +G+ P L P+ + M C
Sbjct: 1250 IWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPL--PDHFSENAADFVRM-CLT 1306
Query: 1505 TKPEKRPLALSVV 1517
+RP AL ++
Sbjct: 1307 RDQHERPSALQLL 1319
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 97.4 bits (241), Expect = 1e-19
Identities = 83/313 (26%), Positives = 144/313 (46%), Gaps = 46/313 (14%)
Query: 1221 ELFMTDFPARLFLENSKLEHSED----EGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKK 1276
E F+ ++F ENS L+ E +G +LG+G GTV QGQ +AVK+ +
Sbjct: 219 EKFLISNEKKIFSENS-LKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDT 277
Query: 1277 FKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISI--HPLCFAL 1334
A A K + + ++E +L AL+H IVA +G + + + +
Sbjct: 278 SNKLA---------------AEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFM 322
Query: 1335 ELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILV 1394
E P S++++++ F PL M+ K QI G+AYLH+ ++ D+K +N+++
Sbjct: 323 EFVPGGSISSIINR------FGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVML 376
Query: 1395 WSLDVKEHINIKLSDYGISRQSFHEGALG--------VEGTPGYQAPEIRPRIVYDEKVD 1446
+ IKL D+G +R+ G G + GTP + APE+ Y K D
Sbjct: 377 MPTGI-----IKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSD 431
Query: 1447 MFSYGMVLYELLSGQRPALGHHQLQIAKKLS--KGIRPVLGQPEEVQFRRLQALMMECWD 1504
++S G ++E+ +G+ P ++ + +G+ P L P+ + M C
Sbjct: 432 IWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPL--PDHFSENAADFVRM-CLT 488
Query: 1505 TKPEKRPLALSVV 1517
+RP AL ++
Sbjct: 489 RDQHERPSALQLL 501
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 97.4 bits (241), Expect = 1e-19
Identities = 104/341 (30%), Positives = 155/341 (45%), Gaps = 26/341 (7%)
Query: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSN 339
+ EL L AN L LP + L+ LRKL LSDN + LP ++ +L+E+D+S N
Sbjct: 38 LEELLLDANQLRELPEQF-FQLVKLRKLGLSDNEIQRLPPEIAN----FMQLVELDVSRN 92
Query: 340 KLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALF 399
++ +P LQ S N L +L E ++ L+ L L ++D L LP
Sbjct: 93 EIPEIPESISFCKALQVADFSGNPLTRLPE-----SFPELQNLTCLSVNDISLQSLPE-N 146
Query: 400 LHSFKSLNSLNVSRNNLKVFPDPWA--CPLKCCKASRNALECLPDKMAVFWKNHLKDVDF 457
+ + +L SL + N L PD L+ N + LP+ + HLKD+
Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALL--HLKDLWL 204
Query: 458 SENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGL- 516
N L E+P + L L+ L + N+L L P+E L L +S+N L DG+
Sbjct: 205 DGNQLSELPQEIGNLKNLLCLDVSENRLERL-PEEISGLTSLTDLVISQNLLETIPDGIG 263
Query: 517 KTKRIAFF-TTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSE 575
K K+++ + R EA ESL L L +N L T+P S+ LK LS
Sbjct: 264 KLKKLSILKVDQNRLTQLPEAVGE-------CESLTELVLTENQLLTLPKSIGKLKKLSN 316
Query: 576 LYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQK 616
L N L LP E+G +L D ++ +PAE+ +
Sbjct: 317 LNADRNK-LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQ 356
Score = 80.5 bits (197), Expect = 2e-14
Identities = 91/306 (29%), Positives = 140/306 (45%), Gaps = 24/306 (7%)
Query: 331 LLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDN 390
L E+ + +N+L LP F L KL+KL S N +++L E N++ +L ELD+S N
Sbjct: 38 LEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPE--IANFM---QLVELDVSRN 92
Query: 391 KLTELPALFLHSFKSLNSLNVSRNNLKVFPD--PWACPLKCCKASRNALECLPDKMAVFW 448
++ E+P + K+L + S N L P+ P L C + +L+ LP+ + +
Sbjct: 93 EIPEIPE-SISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLY 151
Query: 449 KNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQ 508
+L ++ EN L +P L QL L L L N++ L P+ LK L L NQ
Sbjct: 152 --NLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNL-PESIGALLHLKDLWLDGNQ 208
Query: 509 LGK--NEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPS 566
L + E G + + R E S L SL L ++ N L+T+P
Sbjct: 209 LSELPQEIGNLKNLLCLDVSENRLERLPEEISGL-------TSLTDLVISQNLLETIPDG 261
Query: 567 VCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYL 626
+ LK LS L + N L +LP +G+ +L +L + + +P I G LS L
Sbjct: 262 IGKLKKLSILKVDQN-RLTQLPEAVGECESLTELVLTENQLLTLPKSI---GKLKKLSNL 317
Query: 627 RAQLRK 632
A K
Sbjct: 318 NADRNK 323
Score = 73.2 bits (178), Expect = 2e-12
Identities = 76/233 (32%), Positives = 106/233 (45%), Gaps = 19/233 (8%)
Query: 279 QITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISS 338
++ ELDL N + LP I L++L+ L L N L ELP + LL +D+S
Sbjct: 175 RLEELDLGNNEIYNLPESIG-ALLHLKDLWLDGNQLSELPQEIGN----LKNLLCLDVSE 229
Query: 339 NKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIG-LRKLQELDISDNKLTELPA 397
N+L LP L+ L L S+N LE + + IG L+KL L + N+LT+LP
Sbjct: 230 NRLERLPEEISGLTSLTDLVISQNLLETI------PDGIGKLKKLSILKVDQNRLTQLPE 283
Query: 398 LFLHSFKSLNSLNVSRNNLKVFPDPWA--CPLKCCKASRNALECLPDKMAVFWKNHLKDV 455
+ +SL L ++ N L P L A RN L LP ++ L
Sbjct: 284 A-VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS--LTVF 340
Query: 456 DFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQ 508
+N L +P + Q L L + GN+L LP T +LK L LS NQ
Sbjct: 341 CVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP--LSLTALKLKALWLSDNQ 391
Score = 65.9 bits (159), Expect = 4e-10
Identities = 68/237 (28%), Positives = 101/237 (42%), Gaps = 35/237 (14%)
Query: 380 RKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCK--ASRNAL 437
R L+EL + N+L ELP F K L L +S N ++ P A ++ + SRN +
Sbjct: 36 RSLEELLLDANQLRELPEQFFQLVK-LRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEI 94
Query: 438 ECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCR 497
+P+ ++ + L+ DFS N L +P +L L L + L +L P+
Sbjct: 95 PEIPE--SISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSL-PENIGNLY 151
Query: 498 QLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLND 557
L +L+L N L D L R LE L L +
Sbjct: 152 NLASLELRENLLTYLPDSLTQLR----------------------------RLEELDLGN 183
Query: 558 NHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
N + +P S+ L L +L+L N L ELP E+G L NL LD + + +P EI
Sbjct: 184 NEIYNLPESIGALLHLKDLWLDGNQ-LSELPQEIGNLKNLLCLDVSENRLERLPEEI 239
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 95.9 bits (237), Expect = 4e-19
Identities = 105/395 (26%), Positives = 181/395 (45%), Gaps = 45/395 (11%)
Query: 246 LPSSYPGKTALRVKWSHLRLPWVDLDWLIDISC---QITELDLSANCLATLPSVIPWGLI 302
+P + P LRV L L + L C ++ LDL+ N +++LP I L
Sbjct: 272 IPDTLPSLKTLRV----LNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR-ELK 326
Query: 303 NLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKN 362
NL L + N L L + + ++ E+ ++ NKL + + +L+ L KN
Sbjct: 327 NLETLLMDHNKLTFL----AVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKN 382
Query: 363 CLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDP 422
L+ + E+ + L+ L +SDNKLTELP ++H +L L+V+RNN+ D
Sbjct: 383 LLKNIPEKISCC-----AMLECLSLSDNKLTELPK-YIHKLNNLRKLHVNRNNMVKITDC 436
Query: 423 WACPLKCCKA--SRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRL 480
+ C S N + +P ++ K + ++ S N + PLGL LD+L +L +
Sbjct: 437 ISHLNNICSLEFSGNIITDVPIEIKNCQK--IIKIELSYNKIMYFPLGLCALDSLYYLSV 494
Query: 481 QGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVL 540
GN ++ +P ++ +QL L+LS N+L + + + G+ + AS+
Sbjct: 495 NGNYISEIPVDISFS-KQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASIS 553
Query: 541 E----------------FPAFLS--ESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNP 582
FP L E+L+VL L++N L + +C LK + +L +N
Sbjct: 554 NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
Query: 583 GLRELPPELGQLGNLWQLDTEDL---TISNVPAEI 614
+ P EL QL +L QL+ + ++ +P E+
Sbjct: 614 FI-HFPIELCQLQSLEQLNISQIKGRKLTRLPGEL 647
Score = 85.9 bits (211), Expect = 4e-16
Identities = 96/365 (26%), Positives = 162/365 (44%), Gaps = 50/365 (13%)
Query: 279 QITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLE-IDIS 337
+I EL L+ N L + I LR L L N L +P ++I C +LE + +S
Sbjct: 350 KIKELQLADNKLEVISHKIE-NFRELRILILDKNLLKNIP-----EKISCCAMLECLSLS 403
Query: 338 SNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWI------------------GL 379
NKL+ LP L+ L+KL ++N + K+ + + N I
Sbjct: 404 DNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNC 463
Query: 380 RKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALEC 439
+K+ ++++S NK+ P L L + SL L+V+ N + P + + LE
Sbjct: 464 QKIIKIELSYNKIMYFP-LGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH-----LEL 517
Query: 440 LPDKMAVFWKN-----HLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKW 494
+K+ +F ++ +LK +D +N +K++P + + +L L L N+ P +E
Sbjct: 518 SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFP-RELC 576
Query: 495 TCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLS-----ES 549
T L+ LDLS NQL K + +G Q+ + + FP L E
Sbjct: 577 TLENLQVLDLSENQLQKISSDI-------CNLKGIQKLNFSSNQFIHFPIELCQLQSLEQ 629
Query: 550 LEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISN 609
L + + L +P + + L EL + NN +RE+P +G+L NL L + IS
Sbjct: 630 LNISQIKGRKLTRLPGELSNMTQLKELDISNN-AIREIPRNIGELRNLVSLHAYNNQISY 688
Query: 610 VPAEI 614
+P +
Sbjct: 689 LPPSL 693
Score = 73.2 bits (178), Expect = 2e-12
Identities = 91/359 (25%), Positives = 158/359 (44%), Gaps = 63/359 (17%)
Query: 278 CQITE-LDLSANCLATLPSVIPWGLINLRKLNLSDN----------HLGELPGVQSSDEI 326
C + E L LS N L LP I L NLRKL+++ N HL + ++ S I
Sbjct: 394 CAMLECLSLSDNKLTELPKYIH-KLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNI 452
Query: 327 I---------CSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWI 377
I C ++++I++S NK+ + P G L L L+ + N + ++ + + +
Sbjct: 453 ITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFS--- 509
Query: 378 GLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLK------CCK 431
++L L++S+NKL F S +L L++ +N +K P + + CC
Sbjct: 510 --KQLLHLELSENKLLIFSEHFC-SLINLKYLDLGKNQIKKIPASISNMISLHVLILCC- 565
Query: 432 ASRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQ 491
N E P ++ +L+ +D SEN L+++ + L + L NQ P +
Sbjct: 566 ---NKFETFPRELCTL--ENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIE 620
Query: 492 -------EKWTCRQLKTLDLSR--NQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEF 542
E+ Q+K L+R +L N LK I+ R R+ E +++
Sbjct: 621 LCQLQSLEQLNISQIKGRKLTRLPGELS-NMTQLKELDISNNAIREIPRNIGELRNLVSL 679
Query: 543 PAFLSE------------SLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPP 589
A+ ++ L+ L L+ N+L +P ++ + SL E+ +NP LR PP
Sbjct: 680 HAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLR--PP 736
Score = 70.5 bits (171), Expect = 2e-11
Identities = 69/236 (29%), Positives = 112/236 (47%), Gaps = 32/236 (13%)
Query: 274 IDISCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLE 333
I S Q+ L+LS N L LINL+ L+L N + ++P S +I +L
Sbjct: 506 ISFSKQLLHLELSENKLLIFSEHF-CSLINLKYLDLGKNQIKKIPA--SISNMISLHVLI 562
Query: 334 IDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLT 393
+ NK P L LQ L S+N L+K+ +++ L+ +Q+L+ S N+
Sbjct: 563 L--CCNKFETFPRELCTLENLQVLDLSENQLQKI-----SSDICNLKGIQKLNFSSNQFI 615
Query: 394 ELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKNHLK 453
P + L +SL LN+S+ +K K +R LP +++ LK
Sbjct: 616 HFP-IELCQLQSLEQLNISQ-------------IKGRKLTR-----LPGELSNM--TQLK 654
Query: 454 DVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQL 509
++D S NA++E+P + +L L+ L NQ++ LPP + L+ L+LS N L
Sbjct: 655 ELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPP-SLLSLNDLQQLNLSGNNL 709
Score = 45.8 bits (107), Expect = 4e-04
Identities = 28/82 (34%), Positives = 48/82 (58%), Gaps = 1/82 (1%)
Query: 550 LEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISN 609
LE+L L +N L ++P + LL +L L + +N + +P E+ QLGN+ QL + I N
Sbjct: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNH-ISHIPKEISQLGNIRQLFFYNNYIEN 248
Query: 610 VPAEIQKEGPKAMLSYLRAQLR 631
P++++ G +LS + +LR
Sbjct: 249 FPSDLECLGNLEILSLGKNKLR 270
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 92.0 bits (227), Expect = 5e-18
Identities = 85/293 (29%), Positives = 136/293 (46%), Gaps = 44/293 (15%)
Query: 1228 PARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADT 1287
P ++L+ L + E LG G GTV + Y VK +K KN AN PA
Sbjct: 337 PKEVYLDRKLLTLEDKE---LGSGNFGTV--KKGYYQMKKVVKTVAVKILKNEANDPA-- 389
Query: 1288 MLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGI-SIHPLCFALELAPLSSLNTVL 1346
+K+ E EA+++ L +P IV +IGI +E+A L LN L
Sbjct: 390 ----------LKD--ELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 437
Query: 1347 SEN--ARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHIN 1404
+N +D + I L H Q++ G+ YL + N + DL + N+L+ V +H
Sbjct: 438 QQNRHVKDKNIIELVH--------QVSMGMKYLEESNFVHRDLAARNVLL----VTQHY- 484
Query: 1405 IKLSDYGISR-----QSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459
K+SD+G+S+ +++++ + + APE + K D++S+G++++E S
Sbjct: 485 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 544
Query: 1460 -GQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP 1511
GQ+P G ++ L KG R +G P R + LM CW E RP
Sbjct: 545 YGQKPYRGMKGSEVTAMLEKGER--MGCPAGCP-REMYDLMNLCWTYDVENRP 594
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 92.0 bits (227), Expect = 5e-18
Identities = 85/293 (29%), Positives = 136/293 (46%), Gaps = 44/293 (15%)
Query: 1228 PARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADT 1287
P ++L+ L + E LG G GTV + Y VK +K KN AN PA
Sbjct: 360 PKEVYLDRKLLTLEDKE---LGSGNFGTV--KKGYYQMKKVVKTVAVKILKNEANDPA-- 412
Query: 1288 MLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGI-SIHPLCFALELAPLSSLNTVL 1346
+K+ E EA+++ L +P IV +IGI +E+A L LN L
Sbjct: 413 ----------LKD--ELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 460
Query: 1347 SEN--ARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHIN 1404
+N +D + I L H Q++ G+ YL + N + DL + N+L+ V +H
Sbjct: 461 QQNRHVKDKNIIELVH--------QVSMGMKYLEESNFVHRDLAARNVLL----VTQHY- 507
Query: 1405 IKLSDYGISR-----QSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459
K+SD+G+S+ +++++ + + APE + K D++S+G++++E S
Sbjct: 508 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 567
Query: 1460 -GQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP 1511
GQ+P G ++ L KG R +G P R + LM CW E RP
Sbjct: 568 YGQKPYRGMKGSEVTAMLEKGER--MGCPAGCP-REMYDLMNLCWTYDVENRP 617
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 92.0 bits (227), Expect = 5e-18
Identities = 114/369 (30%), Positives = 156/369 (42%), Gaps = 41/369 (11%)
Query: 277 SCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELP------------GVQSSD 324
S + EL L AN L LP + L+NLRKL LSDN + LP V +D
Sbjct: 35 SRSLEELLLDANQLRELPKPF-FRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND 93
Query: 325 --EI-----ICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWI 377
EI C L D S N LS LP GF L L L + L+ L +
Sbjct: 94 IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVG----- 148
Query: 378 GLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDP-WACP-LKCCKASRN 435
L L L++ +N L LPA L L L++ N+L+V PD A P L+ RN
Sbjct: 149 NLANLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRN 207
Query: 436 ALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWT 495
L LP ++ L +D SEN L+E+P L L L L L N L L P
Sbjct: 208 QLSALPPELGNL--RRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRL-PDGIGQ 264
Query: 496 CRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCL 555
+QL L + +N+L + + A ++ P L + ++ L
Sbjct: 265 LKQLSILKVDQNRLCEVTE-------AIGDCENLSELILTENLLMALPRSLGKLTKLTNL 317
Query: 556 N--DNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAE 613
N NHL+ +PP + +LS L L +N L LPPEL L LD + ++P
Sbjct: 318 NVDRNHLEALPPEIGGCVALSVLSLRDN-RLAVLPPELAHTTELHVLDVAGNRLQSLPFA 376
Query: 614 IQKEGPKAM 622
+ KA+
Sbjct: 377 LTHLNLKAL 385
Score = 74.3 bits (181), Expect = 1e-12
Identities = 86/291 (29%), Positives = 123/291 (42%), Gaps = 65/291 (22%)
Query: 328 CSRLLE-IDISSNKLSHLPPGFLHLSK-LQKLTASKNCLEKLFEEENATNWIGLRKLQEL 385
C+R +E +D L +P S+ L++L N L +L + + L L++L
Sbjct: 10 CNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKP-----FFRLLNLRKL 64
Query: 386 DISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMA 445
+SDN++ LP + +F L L+VSRN++ P+ +K CKA
Sbjct: 65 GLSDNEIQRLPPE-VANFMQLVELDVSRNDIPEIPES----IKFCKA------------- 106
Query: 446 VFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLS 505
L+ DFS N L +P G QL +L L L L AL P + L TL+L
Sbjct: 107 ------LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL-PGDVGNLANLVTLELR 159
Query: 506 RNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLS--ESLEVLCLNDNHLDTV 563
N L PA LS LE L L N L+ +
Sbjct: 160 ENLL------------------------------KSLPASLSFLVKLEQLDLGGNDLEVL 189
Query: 564 PPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
P ++ L +L EL+L N L LPPELG L L LD + + +PAE+
Sbjct: 190 PDTLGALPNLRELWLDRNQ-LSALPPELGNLRRLVCLDVSENRLEELPAEL 239
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 92.0 bits (227), Expect = 5e-18
Identities = 114/369 (30%), Positives = 156/369 (42%), Gaps = 41/369 (11%)
Query: 277 SCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELP------------GVQSSD 324
S + EL L AN L LP + L+NLRKL LSDN + LP V +D
Sbjct: 35 SRSLEELLLDANQLRELPKPF-FRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND 93
Query: 325 --EI-----ICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWI 377
EI C L D S N LS LP GF L L L + L+ L +
Sbjct: 94 IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVG----- 148
Query: 378 GLRKLQELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDP-WACP-LKCCKASRN 435
L L L++ +N L LPA L L L++ N+L+V PD A P L+ RN
Sbjct: 149 NLANLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRN 207
Query: 436 ALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWT 495
L LP ++ L +D SEN L+E+P L L L L L N L L P
Sbjct: 208 QLSALPPELGNL--RRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRL-PDGIGQ 264
Query: 496 CRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCL 555
+QL L + +N+L + + A ++ P L + ++ L
Sbjct: 265 LKQLSILKVDQNRLCEVTE-------AIGDCENLSELILTENLLMALPRSLGKLTKLTNL 317
Query: 556 N--DNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAE 613
N NHL+ +PP + +LS L L +N L LPPEL L LD + ++P
Sbjct: 318 NVDRNHLEALPPEIGGCVALSVLSLRDN-RLAVLPPELAHTTELHVLDVAGNRLQSLPFA 376
Query: 614 IQKEGPKAM 622
+ KA+
Sbjct: 377 LTHLNLKAL 385
Score = 74.3 bits (181), Expect = 1e-12
Identities = 86/291 (29%), Positives = 123/291 (42%), Gaps = 65/291 (22%)
Query: 328 CSRLLE-IDISSNKLSHLPPGFLHLSK-LQKLTASKNCLEKLFEEENATNWIGLRKLQEL 385
C+R +E +D L +P S+ L++L N L +L + + L L++L
Sbjct: 10 CNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKP-----FFRLLNLRKL 64
Query: 386 DISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMA 445
+SDN++ LP + +F L L+VSRN++ P+ +K CKA
Sbjct: 65 GLSDNEIQRLPPE-VANFMQLVELDVSRNDIPEIPES----IKFCKA------------- 106
Query: 446 VFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLS 505
L+ DFS N L +P G QL +L L L L AL P + L TL+L
Sbjct: 107 ------LEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQAL-PGDVGNLANLVTLELR 159
Query: 506 RNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLS--ESLEVLCLNDNHLDTV 563
N L PA LS LE L L N L+ +
Sbjct: 160 ENLL------------------------------KSLPASLSFLVKLEQLDLGGNDLEVL 189
Query: 564 PPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
P ++ L +L EL+L N L LPPELG L L LD + + +PAE+
Sbjct: 190 PDTLGALPNLRELWLDRNQ-LSALPPELGNLRRLVCLDVSENRLEELPAEL 239
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 91.7 bits (226), Expect = 7e-18
Identities = 70/243 (28%), Positives = 121/243 (49%), Gaps = 18/243 (7%)
Query: 1297 AMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFAL--ELAPLSSLNTVLSENARDSS 1354
A+K + +EA +L L H I+ G+ + P + + E A L SL ++ N +
Sbjct: 43 AVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEE- 101
Query: 1355 FIPLGHMLTQKIAYQIASGLAYLHKK---NIIFCDLKSDNILVWSLDVKEHINIKLSDYG 1411
+ + H++T A +A G+ YLH + +I DLKS N+++ + V +K+ D+G
Sbjct: 102 -MDMDHIMTW--ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGV-----LKICDFG 153
Query: 1412 ISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQ 1471
SR H + + GT + APE+ + E D +SYG+VL+E+L+ + P G LQ
Sbjct: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213
Query: 1472 IA-KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMY 1530
+A + K R L P R L+ +CW+ +KRP ++S ++ + T +
Sbjct: 214 VAWLVVEKNER--LTIPSSCP-RSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLP 270
Query: 1531 ELC 1533
+ C
Sbjct: 271 DKC 273
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 91.7 bits (226), Expect = 7e-18
Identities = 70/243 (28%), Positives = 121/243 (49%), Gaps = 18/243 (7%)
Query: 1297 AMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFAL--ELAPLSSLNTVLSENARDSS 1354
A+K + +EA +L L H I+ G+ + P + + E A L SL ++ N +
Sbjct: 43 AVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEE- 101
Query: 1355 FIPLGHMLTQKIAYQIASGLAYLHKK---NIIFCDLKSDNILVWSLDVKEHINIKLSDYG 1411
+ + H++T A +A G+ YLH + +I DLKS N+++ + V +K+ D+G
Sbjct: 102 -MDMDHIMTW--ATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGV-----LKICDFG 153
Query: 1412 ISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQ 1471
SR H + + GT + APE+ + E D +SYG+VL+E+L+ + P G LQ
Sbjct: 154 ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQ 213
Query: 1472 IA-KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMY 1530
+A + K R L P R L+ +CW+ +KRP ++S ++ + T +
Sbjct: 214 VAWLVVEKNER--LTIPSSCP-RSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLP 270
Query: 1531 ELC 1533
+ C
Sbjct: 271 DKC 273
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 89.4 bits (220), Expect = 3e-17
Identities = 97/344 (28%), Positives = 157/344 (45%), Gaps = 25/344 (7%)
Query: 277 SCQ-ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEI- 334
+CQ + +L + N L+ LP+ I L+NL++L++S N + E P + I C + L I
Sbjct: 67 NCQALRKLSIPDNDLSNLPTTIA-SLVNLKELDISKNGVQEFP-----ENIKCCKCLTII 120
Query: 335 DISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTE 394
+ S N +S LP GF L L +L + LE L N+ L KL+ L++ +N L
Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFL-----PANFGRLVKLRILELRENHLKT 175
Query: 395 LPALFLHSFKSLNSLNVSRNNLKVFPD--PWACPLKCCKASRNALECLPDKMAVFWKNHL 452
LP +H L L++ N P+ L+ NAL+ LP + L
Sbjct: 176 LPKS-MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKL--KML 232
Query: 453 KDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKN 512
+D S+N ++ V + + +AL L L N L LP ++L TL + NQL
Sbjct: 233 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVDDNQLTML 291
Query: 513 EDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKS 572
+ + + S E S+ +L SL L +++N L +P + K+
Sbjct: 292 PNTIGNLSLL----EEFDCSCNELESLPSTIGYL-HSLRTLAVDENFLPELPREIGSCKN 346
Query: 573 LSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQK 616
++ + L +N L LP E+GQ+ L L+ D + N+P K
Sbjct: 347 VTVMSLRSNK-LEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTK 389
Score = 68.9 bits (167), Expect = 5e-11
Identities = 89/337 (26%), Positives = 139/337 (41%), Gaps = 44/337 (13%)
Query: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSN 339
I+ LD S L +P + L +L L N + ELP C L ++ I N
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELP----KQLFNCQALRKLSIPDN 79
Query: 340 KLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALF 399
LS+LP L L++L SKN +++ E + + ++ S N +++LP F
Sbjct: 80 DLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI-----IEASVNPISKLPDGF 134
Query: 400 LHSFKSLNSLNVSRNNLKVFPDPWA--CPLKCCKASRNALECLPDKMAVFWKNHLKDVDF 457
+L L ++ L+ P + L+ + N L+ LP M L+ +D
Sbjct: 135 T-QLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKL--AQLERLDL 191
Query: 458 SENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNEDGLK 517
N E+P L Q+ L L + N L L P + L LD+S+N++
Sbjct: 192 GNNEFGELPEVLDQIQNLRELWMDNNALQVL-PGSIGKLKMLVYLDMSKNRI-------- 242
Query: 518 TKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPSVCLLKSLSELY 577
T SG EA LE L L+ N L +P S+ LLK L+ L
Sbjct: 243 -------ETVDMDISGCEA-------------LEDLLLSSNMLQQLPDSIGLLKKLTTLK 282
Query: 578 LGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
+ +N L LP +G L L + D + ++P+ I
Sbjct: 283 VDDNQ-LTMLPNTIGNLSLLEEFDCSCNELESLPSTI 318
Score = 55.8 bits (133), Expect = 4e-07
Identities = 64/220 (29%), Positives = 98/220 (44%), Gaps = 24/220 (10%)
Query: 433 SRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQE 492
S +L+ +P ++ F + L+++ N ++E+P LF AL L + N L+ LP
Sbjct: 30 SHCSLQQVPKEVFNFERT-LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTI 88
Query: 493 KWTCRQLKTLDLSRNQLGKNEDGLK---------------TKRIAFFTTRGRQRSGTEAA 537
+ LK LD+S+N + + + +K +K FT
Sbjct: 89 A-SLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLND 147
Query: 538 SVLEF-PAFLSE--SLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQL 594
+ LEF PA L +L L +NHL T+P S+ L L L LGNN ELP L Q+
Sbjct: 148 AFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNE-FGELPEVLDQI 206
Query: 595 GNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLRAQLRKAE 634
NL +L ++ + +P I G ML YL + E
Sbjct: 207 QNLRELWMDNNALQVLPGSI---GKLKMLVYLDMSKNRIE 243
Score = 50.4 bits (119), Expect = 2e-05
Identities = 60/184 (32%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 253 KTALRVKWSHLRLPWVDLDWLIDISCQITELDLSANCLATLPSVIPWGLIN-LRKLNLSD 311
K + + S R+ VD+D I + +L LS+N L LP I GL+ L L + D
Sbjct: 230 KMLVYLDMSKNRIETVDMD--ISGCEALEDLLLSSNMLQQLPDSI--GLLKKLTTLKVDD 285
Query: 312 NHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEE- 370
N L LP + S L E D S N+L LP +L L+ L +N L +L E
Sbjct: 286 NQLTMLPNTIGN----LSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREI 341
Query: 371 ---ENAT-------------NWIG-LRKLQELDISDNKLTELPALFLHSFKSLNSLNVSR 413
+N T IG ++KL+ L++SDN+L LP F K L +L +S
Sbjct: 342 GSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFT-KLKELAALWLSD 400
Query: 414 NNLK 417
N K
Sbjct: 401 NQSK 404
>gi|21735566 mitogen-activated protein kinase kinase kinase 7 isoform
D [Homo sapiens]
Length = 491
Score = 89.0 bits (219), Expect = 4e-17
Identities = 79/303 (26%), Positives = 141/303 (46%), Gaps = 42/303 (13%)
Query: 1224 MTDFPARLFLENSKLEHSEDE-GSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFAN 1282
M + P+++ L ++++ E E V+G+G G V+ +A+++ + VA+K+ + +
Sbjct: 18 MIEAPSQV-LNFEEIDYKEIEVEEVVGRGAFG-VVCKAKWRAKDVAIKQIESESERK--- 72
Query: 1283 VPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSL 1342
F E L + HP IV L G ++P+C +E A SL
Sbjct: 73 --------------------AFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSL 112
Query: 1343 NTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK---KNIIFCDLKSDNILVWSLDV 1399
VL A + H ++ + Q + G+AYLH K +I DLK N+L+ V
Sbjct: 113 YNVL-HGAEPLPYYTAAHAMSWCL--QCSQGVAYLHSMQPKALIHRDLKPPNLLL----V 165
Query: 1400 KEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459
+K+ D+G + +G+ + APE+ Y EK D+FS+G++L+E+++
Sbjct: 166 AGGTVLKICDFGTACD-IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 1460 GQRP--ALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVV 1517
++P +G +I + G RP L + + +++LM CW P +RP +V
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP---KPIESLMTRCWSKDPSQRPSMEEIV 281
Query: 1518 SQM 1520
M
Sbjct: 282 KIM 284
>gi|21735564 mitogen-activated protein kinase kinase kinase 7 isoform
C [Homo sapiens]
Length = 518
Score = 89.0 bits (219), Expect = 4e-17
Identities = 79/303 (26%), Positives = 141/303 (46%), Gaps = 42/303 (13%)
Query: 1224 MTDFPARLFLENSKLEHSEDE-GSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFAN 1282
M + P+++ L ++++ E E V+G+G G V+ +A+++ + VA+K+ + +
Sbjct: 18 MIEAPSQV-LNFEEIDYKEIEVEEVVGRGAFG-VVCKAKWRAKDVAIKQIESESERK--- 72
Query: 1283 VPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSL 1342
F E L + HP IV L G ++P+C +E A SL
Sbjct: 73 --------------------AFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSL 112
Query: 1343 NTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK---KNIIFCDLKSDNILVWSLDV 1399
VL A + H ++ + Q + G+AYLH K +I DLK N+L+ V
Sbjct: 113 YNVL-HGAEPLPYYTAAHAMSWCL--QCSQGVAYLHSMQPKALIHRDLKPPNLLL----V 165
Query: 1400 KEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459
+K+ D+G + +G+ + APE+ Y EK D+FS+G++L+E+++
Sbjct: 166 AGGTVLKICDFGTACD-IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 1460 GQRP--ALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVV 1517
++P +G +I + G RP L + + +++LM CW P +RP +V
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP---KPIESLMTRCWSKDPSQRPSMEEIV 281
Query: 1518 SQM 1520
M
Sbjct: 282 KIM 284
>gi|21735562 mitogen-activated protein kinase kinase kinase 7 isoform
B [Homo sapiens]
Length = 606
Score = 89.0 bits (219), Expect = 4e-17
Identities = 79/303 (26%), Positives = 141/303 (46%), Gaps = 42/303 (13%)
Query: 1224 MTDFPARLFLENSKLEHSEDE-GSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFAN 1282
M + P+++ L ++++ E E V+G+G G V+ +A+++ + VA+K+ + +
Sbjct: 18 MIEAPSQV-LNFEEIDYKEIEVEEVVGRGAFG-VVCKAKWRAKDVAIKQIESESERK--- 72
Query: 1283 VPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSL 1342
F E L + HP IV L G ++P+C +E A SL
Sbjct: 73 --------------------AFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSL 112
Query: 1343 NTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK---KNIIFCDLKSDNILVWSLDV 1399
VL A + H ++ + Q + G+AYLH K +I DLK N+L+ V
Sbjct: 113 YNVL-HGAEPLPYYTAAHAMSWCL--QCSQGVAYLHSMQPKALIHRDLKPPNLLL----V 165
Query: 1400 KEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459
+K+ D+G + +G+ + APE+ Y EK D+FS+G++L+E+++
Sbjct: 166 AGGTVLKICDFGTACD-IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 1460 GQRP--ALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVV 1517
++P +G +I + G RP L + + +++LM CW P +RP +V
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP---KPIESLMTRCWSKDPSQRPSMEEIV 281
Query: 1518 SQM 1520
M
Sbjct: 282 KIM 284
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform A
[Homo sapiens]
Length = 579
Score = 89.0 bits (219), Expect = 4e-17
Identities = 79/303 (26%), Positives = 141/303 (46%), Gaps = 42/303 (13%)
Query: 1224 MTDFPARLFLENSKLEHSEDE-GSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFAN 1282
M + P+++ L ++++ E E V+G+G G V+ +A+++ + VA+K+ + +
Sbjct: 18 MIEAPSQV-LNFEEIDYKEIEVEEVVGRGAFG-VVCKAKWRAKDVAIKQIESESERK--- 72
Query: 1283 VPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIHPLCFALELAPLSSL 1342
F E L + HP IV L G ++P+C +E A SL
Sbjct: 73 --------------------AFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSL 112
Query: 1343 NTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK---KNIIFCDLKSDNILVWSLDV 1399
VL A + H ++ + Q + G+AYLH K +I DLK N+L+ V
Sbjct: 113 YNVL-HGAEPLPYYTAAHAMSWCL--QCSQGVAYLHSMQPKALIHRDLKPPNLLL----V 165
Query: 1400 KEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459
+K+ D+G + +G+ + APE+ Y EK D+FS+G++L+E+++
Sbjct: 166 AGGTVLKICDFGTACD-IQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
Query: 1460 GQRP--ALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRPLALSVV 1517
++P +G +I + G RP L + + +++LM CW P +RP +V
Sbjct: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLP---KPIESLMTRCWSKDPSQRPSMEEIV 281
Query: 1518 SQM 1520
M
Sbjct: 282 KIM 284
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 88.6 bits (218), Expect = 6e-17
Identities = 95/345 (27%), Positives = 155/345 (44%), Gaps = 27/345 (7%)
Query: 277 SCQ-ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEID 335
+CQ + +L L N L TLP+ I LINLR+L++S N + E P + C L ++
Sbjct: 67 NCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKNGIQEFPENIKN----CKVLTIVE 121
Query: 336 ISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTEL 395
S N +S LP GF L L +L + LE L N+ L KLQ L++ +N+L L
Sbjct: 122 ASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL-----PANFGRLTKLQILELRENQLKML 176
Query: 396 PALFLHSFKSLNSLNVSRNNLKVFPD--PWACPLKCCKASRNALECLPDKMAVFWKNHLK 453
P ++ L L++ N P+ LK N L +P + L
Sbjct: 177 PKT-MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL--KQLT 233
Query: 454 DVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNE 513
+D S+N ++ V G+ + L L L N L LP + + + + TL + NQL
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLP 292
Query: 514 DGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSE--SLEVLCLNDNHLDTVPPSVCLLK 571
D + + S E ++ P+ + + +L + N+L +PP + K
Sbjct: 293 DSIG----GLISVEELDCSFNEVEAL---PSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
Query: 572 SLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQK 616
+++ L+L +N L LP E+G + L ++ D + N+P K
Sbjct: 346 NITVLFLHSNK-LETLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389
Score = 72.8 bits (177), Expect = 3e-12
Identities = 75/290 (25%), Positives = 133/290 (45%), Gaps = 30/290 (10%)
Query: 334 IDISSNKLSHLPPGFLHLSK-LQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKL 392
+D S L +P K L++L N +E+L ++ + L +L + DN L
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQ-----LFNCQSLHKLSLPDNDL 81
Query: 393 TELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCK------ASRNALECLPDKMAV 446
T LPA + + +L L+VS+N ++ FP+ +K CK AS N + LPD +
Sbjct: 82 TTLPA-SIANLINLRELDVSKNGIQEFPE----NIKNCKVLTIVEASVNPISKLPDGFSQ 136
Query: 447 FWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSR 506
+L + ++ L+ +P +L L L L+ NQL LP QL+ LDL
Sbjct: 137 LL--NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMN-RLTQLERLDLGS 193
Query: 507 NQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLS--ESLEVLCLNDNHLDTVP 564
N+ + + L+ G + +A + P F+ + L L ++ N+++ V
Sbjct: 194 NEFTEVPEVLE-------QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 565 PSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
+ ++L +L L +N L++LP +G L N+ L ++ + +P I
Sbjct: 247 EGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
Score = 48.5 bits (114), Expect = 6e-05
Identities = 48/186 (25%), Positives = 83/186 (44%), Gaps = 12/186 (6%)
Query: 433 SRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQE 492
S +LE +P ++ F K L+++ N ++E+P LF +L L L N L LP
Sbjct: 30 SHCSLEQVPKEIFTFEKT-LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASI 88
Query: 493 KWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEV 552
L+ LD+S+N + + + +K ++ + + P S+ L +
Sbjct: 89 A-NLINLRELDVSKNGIQEFPENIKNCKVLTIVE-------ASVNPISKLPDGFSQLLNL 140
Query: 553 --LCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNV 610
L LND L+ +P + L L L L N L+ LP + +L L +LD + V
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQ-LKMLPKTMNRLTQLERLDLGSNEFTEV 199
Query: 611 PAEIQK 616
P +++
Sbjct: 200 PEVLEQ 205
Score = 44.3 bits (103), Expect = 0.001
Identities = 44/138 (31%), Positives = 64/138 (46%), Gaps = 11/138 (7%)
Query: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSN 339
IT L + N L LP I GLI++ +L+ S N + LP S ++ R D N
Sbjct: 278 ITTLKIDENQLMYLPDSIG-GLISVEELDCSFNEVEALPS--SIGQLTNLRTFAAD--HN 332
Query: 340 KLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALF 399
L LPP + L N LE L EE ++KL+ +++SDN+L LP F
Sbjct: 333 YLQQLPPEIGSWKNITVLFLHSNKLETLPEEMG-----DMQKLKVINLSDNRLKNLPFSF 387
Query: 400 LHSFKSLNSLNVSRNNLK 417
+ L ++ +S N K
Sbjct: 388 T-KLQQLTAMWLSDNQSK 404
Score = 35.8 bits (81), Expect = 0.44
Identities = 38/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 535 EAASVLEFPA--FLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELG 592
+A + E P F +SL L L DN L T+P S+ L +L EL + N G++E P +
Sbjct: 54 DANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKN-GIQEFPENIK 112
Query: 593 QLGNLWQLDTEDLTISNVPAEI-------QKEGPKAMLSYLRAQLRKAEKCKLMKM---- 641
L ++ IS +P Q A L +L A + K +++++
Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQ 172
Query: 642 IIVGPPRQGKSTLLEILQTG 661
+ + P + T LE L G
Sbjct: 173 LKMLPKTMNRLTQLERLDLG 192
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 88.6 bits (218), Expect = 6e-17
Identities = 95/345 (27%), Positives = 155/345 (44%), Gaps = 27/345 (7%)
Query: 277 SCQ-ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEID 335
+CQ + +L L N L TLP+ I LINLR+L++S N + E P + C L ++
Sbjct: 67 NCQSLHKLSLPDNDLTTLPASIA-NLINLRELDVSKNGIQEFPENIKN----CKVLTIVE 121
Query: 336 ISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTEL 395
S N +S LP GF L L +L + LE L N+ L KLQ L++ +N+L L
Sbjct: 122 ASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL-----PANFGRLTKLQILELRENQLKML 176
Query: 396 PALFLHSFKSLNSLNVSRNNLKVFPD--PWACPLKCCKASRNALECLPDKMAVFWKNHLK 453
P ++ L L++ N P+ LK N L +P + L
Sbjct: 177 PKT-MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL--KQLT 233
Query: 454 DVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQLGKNE 513
+D S+N ++ V G+ + L L L N L LP + + + + TL + NQL
Sbjct: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLP 292
Query: 514 DGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSE--SLEVLCLNDNHLDTVPPSVCLLK 571
D + + S E ++ P+ + + +L + N+L +PP + K
Sbjct: 293 DSIG----GLISVEELDCSFNEVEAL---PSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
Query: 572 SLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQK 616
+++ L+L +N L LP E+G + L ++ D + N+P K
Sbjct: 346 NITVLFLHSNK-LETLPEEMGDMQKLKVINLSDNRLKNLPFSFTK 389
Score = 72.8 bits (177), Expect = 3e-12
Identities = 75/290 (25%), Positives = 133/290 (45%), Gaps = 30/290 (10%)
Query: 334 IDISSNKLSHLPPGFLHLSK-LQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKL 392
+D S L +P K L++L N +E+L ++ + L +L + DN L
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQ-----LFNCQSLHKLSLPDNDL 81
Query: 393 TELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCK------ASRNALECLPDKMAV 446
T LPA + + +L L+VS+N ++ FP+ +K CK AS N + LPD +
Sbjct: 82 TTLPA-SIANLINLRELDVSKNGIQEFPE----NIKNCKVLTIVEASVNPISKLPDGFSQ 136
Query: 447 FWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSR 506
+L + ++ L+ +P +L L L L+ NQL LP QL+ LDL
Sbjct: 137 LL--NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMN-RLTQLERLDLGS 193
Query: 507 NQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLS--ESLEVLCLNDNHLDTVP 564
N+ + + L+ G + +A + P F+ + L L ++ N+++ V
Sbjct: 194 NEFTEVPEVLE-------QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
Query: 565 PSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEI 614
+ ++L +L L +N L++LP +G L N+ L ++ + +P I
Sbjct: 247 EGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
Score = 48.5 bits (114), Expect = 6e-05
Identities = 48/186 (25%), Positives = 83/186 (44%), Gaps = 12/186 (6%)
Query: 433 SRNALECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQE 492
S +LE +P ++ F K L+++ N ++E+P LF +L L L N L LP
Sbjct: 30 SHCSLEQVPKEIFTFEKT-LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASI 88
Query: 493 KWTCRQLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEV 552
L+ LD+S+N + + + +K ++ + + P S+ L +
Sbjct: 89 A-NLINLRELDVSKNGIQEFPENIKNCKVLTIVE-------ASVNPISKLPDGFSQLLNL 140
Query: 553 --LCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNV 610
L LND L+ +P + L L L L N L+ LP + +L L +LD + V
Sbjct: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQ-LKMLPKTMNRLTQLERLDLGSNEFTEV 199
Query: 611 PAEIQK 616
P +++
Sbjct: 200 PEVLEQ 205
Score = 44.3 bits (103), Expect = 0.001
Identities = 44/138 (31%), Positives = 64/138 (46%), Gaps = 11/138 (7%)
Query: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSN 339
IT L + N L LP I GLI++ +L+ S N + LP S ++ R D N
Sbjct: 278 ITTLKIDENQLMYLPDSIG-GLISVEELDCSFNEVEALPS--SIGQLTNLRTFAAD--HN 332
Query: 340 KLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALF 399
L LPP + L N LE L EE ++KL+ +++SDN+L LP F
Sbjct: 333 YLQQLPPEIGSWKNITVLFLHSNKLETLPEEMG-----DMQKLKVINLSDNRLKNLPFSF 387
Query: 400 LHSFKSLNSLNVSRNNLK 417
+ L ++ +S N K
Sbjct: 388 T-KLQQLTAMWLSDNQSK 404
Score = 35.8 bits (81), Expect = 0.44
Identities = 38/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 535 EAASVLEFPA--FLSESLEVLCLNDNHLDTVPPSVCLLKSLSELYLGNNPGLRELPPELG 592
+A + E P F +SL L L DN L T+P S+ L +L EL + N G++E P +
Sbjct: 54 DANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKN-GIQEFPENIK 112
Query: 593 QLGNLWQLDTEDLTISNVPAEI-------QKEGPKAMLSYLRAQLRKAEKCKLMKM---- 641
L ++ IS +P Q A L +L A + K +++++
Sbjct: 113 NCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQ 172
Query: 642 IIVGPPRQGKSTLLEILQTG 661
+ + P + T LE L G
Sbjct: 173 LKMLPKTMNRLTQLERLDLG 192
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 86.7 bits (213), Expect = 2e-16
Identities = 69/225 (30%), Positives = 116/225 (51%), Gaps = 33/225 (14%)
Query: 1302 SEFRQEASMLHALQHPCIVALIGISI--HPLCFALELAPLSSLNTVLSENARDSSFIPLG 1359
++F +EA ++ L+HP ++ L + P+ EL SL L +
Sbjct: 272 NDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIH---- 327
Query: 1360 HMLTQKI--AYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISR--- 1414
LTQ++ A Q+ASG+AYL +N I DL + N+L V EH K++D+G++R
Sbjct: 328 --LTQQVDMAAQVASGMAYLESRNYIHRDLAARNVL-----VGEHNIYKVADFGLARVFK 380
Query: 1415 -------QSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS-GQRPALG 1466
+S HE L V+ T APE + K D++S+G++LYE+++ G+ P G
Sbjct: 381 VDNEDIYESRHEIKLPVKWT----APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSG 436
Query: 1467 HHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP 1511
Q+ + L++ R L QP ++ +M+ECW+ +P++RP
Sbjct: 437 MTGAQVIQMLAQNYR--LPQPSNCP-QQFYNIMLECWNAEPKERP 478
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 86.7 bits (213), Expect = 2e-16
Identities = 88/311 (28%), Positives = 148/311 (47%), Gaps = 46/311 (14%)
Query: 1222 LFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFA 1281
L P+ L+ S++E E ++G G G V Y+ R + + VA+KR+ + + +
Sbjct: 447 LLRAGLPSHFHLQLSEIEFHE----IIGSGSFGKV-YKGRCRNKIVAIKRYRANTYCSKS 501
Query: 1282 NVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIH-PLCFALELAPLS 1340
+V F +E S+L L HPC++ +G ++ P FA+ +S
Sbjct: 502 DVDM------------------FCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYIS 543
Query: 1341 --SLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK--KNIIFCDLKSDNILVWS 1396
SL ++L E R + L L IA +A G+ YLH + II DL S NIL++
Sbjct: 544 GGSLFSLLHEQKR---ILDLQSKLI--IAVDVAKGMEYLHNLTQPIIHRDLNSHNILLY- 597
Query: 1397 LDVKEHINIKLSDYGISR--QSFHEGALGVE-GTPGYQAPEIRPRIV-YDEKVDMFSYGM 1452
E + ++D+G SR QS E + + G + APE+ + Y K D+FSY +
Sbjct: 598 ----EDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYAL 653
Query: 1453 VLYELLSGQRPALGHHQLQIAKKLS-KGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP 1511
L+E+L+G+ P A ++ IRP +G + + +L++ W+ PE RP
Sbjct: 654 CLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIP---KPISSLLIRGWNACPEGRP 710
Query: 1512 LALSVVSQMKD 1522
VV ++++
Sbjct: 711 EFSEVVMKLEE 721
Score = 32.0 bits (71), Expect = 6.3
Identities = 26/93 (27%), Positives = 44/93 (47%), Gaps = 6/93 (6%)
Query: 123 PAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPES 182
P +AAY+GH V + LL+ + + L LA +G L + KLL + G+ +
Sbjct: 170 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL-MEEGSKADV 228
Query: 183 YAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLR 215
A + +PL+ + G+ DI +LL+
Sbjct: 229 NAQDNED-----HVPLHFCSRFGHHDIVKYLLQ 256
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 86.7 bits (213), Expect = 2e-16
Identities = 88/311 (28%), Positives = 148/311 (47%), Gaps = 46/311 (14%)
Query: 1222 LFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFA 1281
L P+ L+ S++E E ++G G G V Y+ R + + VA+KR+ + + +
Sbjct: 548 LLRAGLPSHFHLQLSEIEFHE----IIGSGSFGKV-YKGRCRNKIVAIKRYRANTYCSKS 602
Query: 1282 NVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIH-PLCFALELAPLS 1340
+V F +E S+L L HPC++ +G ++ P FA+ +S
Sbjct: 603 DVDM------------------FCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYIS 644
Query: 1341 --SLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHK--KNIIFCDLKSDNILVWS 1396
SL ++L E R + L L IA +A G+ YLH + II DL S NIL++
Sbjct: 645 GGSLFSLLHEQKR---ILDLQSKLI--IAVDVAKGMEYLHNLTQPIIHRDLNSHNILLY- 698
Query: 1397 LDVKEHINIKLSDYGISR--QSFHEGALGVE-GTPGYQAPEIRPRIV-YDEKVDMFSYGM 1452
E + ++D+G SR QS E + + G + APE+ + Y K D+FSY +
Sbjct: 699 ----EDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYAL 754
Query: 1453 VLYELLSGQRPALGHHQLQIAKKLS-KGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP 1511
L+E+L+G+ P A ++ IRP +G + + +L++ W+ PE RP
Sbjct: 755 CLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIP---KPISSLLIRGWNACPEGRP 811
Query: 1512 LALSVVSQMKD 1522
VV ++++
Sbjct: 812 EFSEVVMKLEE 822
Score = 32.0 bits (71), Expect = 6.3
Identities = 26/93 (27%), Positives = 44/93 (47%), Gaps = 6/93 (6%)
Query: 123 PAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPES 182
P +AAY+GH V + LL+ + + L LA +G L + KLL + G+ +
Sbjct: 271 PLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL-MEEGSKADV 329
Query: 183 YAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLR 215
A + +PL+ + G+ DI +LL+
Sbjct: 330 NAQDNED-----HVPLHFCSRFGHHDIVKYLLQ 357
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 85.5 bits (210), Expect = 5e-16
Identities = 78/278 (28%), Positives = 120/278 (43%), Gaps = 67/278 (24%)
Query: 1248 LGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQE 1307
+G G G V + R+ G+ VAVK+ K +T ++HLR
Sbjct: 131 VGSGAQGAV-FLGRFHGEEVAVKKVRDLK---------ETDIKHLRK------------- 167
Query: 1308 ASMLHALQHPCIVALIGISIHPLCFAL--ELAPLSSLNTVLSENARDSSFIPLGHMLTQK 1365
L+HP I+ G+ C+ + E L VL P+ L
Sbjct: 168 ------LKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGR------PVTPSLLVD 215
Query: 1366 IAYQIASGLAYLHKKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQ-SFHEGALGV 1424
+ IA G+ YLH II DLKS N+L+ DV +K+SD+G S++ S +
Sbjct: 216 WSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDV-----VKISDFGTSKELSDKSTKMSF 270
Query: 1425 EGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRP-----------ALGHHQLQIA 1473
GT + APE+ EKVD++S+G+VL+ELL+G+ P +G + L +
Sbjct: 271 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL- 329
Query: 1474 KKLSKGIRPVLGQPEEVQFRRLQALMMECWDTKPEKRP 1511
PV + + L+ +CW++KP RP
Sbjct: 330 --------PVPSSCPD----GFKILLRQCWNSKPRNRP 355
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,209,288
Number of Sequences: 37866
Number of extensions: 3847935
Number of successful extensions: 15591
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 417
Number of HSP's successfully gapped in prelim test: 705
Number of HSP's that attempted gapping in prelim test: 11562
Number of HSP's gapped (non-prelim): 2650
length of query: 2015
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1898
effective length of database: 13,817,196
effective search space: 26225038008
effective search space used: 26225038008
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.