Search of human proteins with 90577167

Search of human proteins with 90577167

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo
sapiens]
         (1148 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...  2325   0.0  
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...  2163   0.0  
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...  2162   0.0  
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...  2000   0.0  
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa...   835   0.0  
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa...   829   0.0  
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]   125   2e-28
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]   125   2e-28
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]   125   2e-28
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]              120   7e-27
gi|13375952 TBC1 domain family, member 17 [Homo sapiens]              118   4e-26
gi|54607014 TBC1 domain family, member 25 [Homo sapiens]              107   5e-23
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    63   1e-09
gi|222352143 TBC1 domain family, member 2 [Homo sapiens]               58   5e-08
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa...    55   4e-07
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]              54   9e-07
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    54   9e-07
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    54   9e-07
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]              54   1e-06
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap...    53   1e-06
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap...    53   1e-06
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap...    53   1e-06
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    49   4e-05
gi|22507409 TBC1 domain family, member 22A [Homo sapiens]              49   4e-05
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]    49   4e-05
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]    49   4e-05
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]    49   4e-05
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               44   7e-04
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...    43   0.002
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]     42   0.004

>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score = 2325 bits (6024), Expect = 0.0
 Identities = 1148/1148 (100%), Positives = 1148/1148 (100%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP
Sbjct: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
            KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE
Sbjct: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660

Query: 661  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720
            WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL
Sbjct: 661  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720

Query: 721  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780
            HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS
Sbjct: 721  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780

Query: 781  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840
            EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD
Sbjct: 781  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840

Query: 841  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900
            LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP
Sbjct: 841  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900

Query: 901  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960
            ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK
Sbjct: 901  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960

Query: 961  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020
            LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD
Sbjct: 961  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020

Query: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080
            THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA
Sbjct: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080

Query: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140
            KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK
Sbjct: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140

Query: 1141 VQTLIENK 1148
            VQTLIENK
Sbjct: 1141 VQTLIENK 1148


>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score = 2163 bits (5604), Expect = 0.0
 Identities = 1083/1148 (94%), Positives = 1084/1148 (94%), Gaps = 61/1148 (5%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP
Sbjct: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
            KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE  +            
Sbjct: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQ------------ 648

Query: 661  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720
                                  CSSG                            RQNIRL
Sbjct: 649  ---------------------SCSSG----------------------------RQNIRL 659

Query: 721  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780
            HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS
Sbjct: 660  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 719

Query: 781  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840
            EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD
Sbjct: 720  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 779

Query: 841  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900
            LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP
Sbjct: 780  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 839

Query: 901  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960
            ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK
Sbjct: 840  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 899

Query: 961  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020
            LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD
Sbjct: 900  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 959

Query: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080
            THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA
Sbjct: 960  THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1019

Query: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140
            KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK
Sbjct: 1020 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1079

Query: 1141 VQTLIENK 1148
            VQTLIENK
Sbjct: 1080 VQTLIENK 1087


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score = 2162 bits (5602), Expect = 0.0
 Identities = 1086/1148 (94%), Positives = 1088/1148 (94%), Gaps = 55/1148 (4%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFV  D +     VSV                            + LP    
Sbjct: 421  IIYPGMQSEFVPQDLM----DVSV----------------------------SNLP---- 444

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
                               SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 445  -------------------SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 485

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 486  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 545

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE
Sbjct: 546  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 605

Query: 661  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720
            WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL
Sbjct: 606  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 665

Query: 721  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780
            HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS
Sbjct: 666  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 725

Query: 781  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840
            EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD
Sbjct: 726  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 785

Query: 841  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900
            LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP
Sbjct: 786  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 845

Query: 901  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960
            ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK
Sbjct: 846  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 905

Query: 961  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020
            LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD
Sbjct: 906  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 965

Query: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080
            THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA
Sbjct: 966  THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1025

Query: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140
            KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK
Sbjct: 1026 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1085

Query: 1141 VQTLIENK 1148
            VQTLIENK
Sbjct: 1086 VQTLIENK 1093


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 1032

 Score = 2000 bits (5182), Expect = 0.0
 Identities = 1021/1148 (88%), Positives = 1024/1148 (89%), Gaps = 116/1148 (10%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFV  D +     VSV                            + LP    
Sbjct: 421  IIYPGMQSEFVPQDLM----DVSV----------------------------SNLP---- 444

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
                               SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 445  -------------------SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 485

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 486  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 545

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE  +            
Sbjct: 546  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQ------------ 593

Query: 661  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720
                                  CSSG                            RQNIRL
Sbjct: 594  ---------------------SCSSG----------------------------RQNIRL 604

Query: 721  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780
            HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS
Sbjct: 605  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 664

Query: 781  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840
            EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD
Sbjct: 665  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 724

Query: 841  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900
            LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP
Sbjct: 725  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 784

Query: 901  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960
            ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK
Sbjct: 785  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 844

Query: 961  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020
            LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD
Sbjct: 845  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 904

Query: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080
            THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA
Sbjct: 905  THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 964

Query: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140
            KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK
Sbjct: 965  KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1024

Query: 1141 VQTLIENK 1148
            VQTLIENK
Sbjct: 1025 VQTLIENK 1032


>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 1051

 Score =  835 bits (2158), Expect = 0.0
 Identities = 461/854 (53%), Positives = 570/854 (66%), Gaps = 70/854 (8%)

Query: 6   AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
           AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 4   AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63

Query: 66  RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
           RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 64  RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123

Query: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
           P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183

Query: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241
           TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243

Query: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
           R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303

Query: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
           GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362

Query: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
           FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420

Query: 422 IYPGMQSEFVAPDF--LGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPS 479
           IYPG + E +  ++  L ++ + SV           +ML +              L  P+
Sbjct: 421 IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMI---------CSRNLTAPN 471

Query: 480 PKEQPPMPQDLMDVSVSNLPSLWQPSP---RKSSCSSCSQSGSADGSSTN-GCNHERAPL 535
           P +      ++     S LP+ W   P   + SSC SCS S S   + ++  C  +R PL
Sbjct: 472 PMKDAGDMIEMQGFGPS-LPA-WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPL 529

Query: 536 KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 595
           +LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W 
Sbjct: 530 RLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWS 589

Query: 596 QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 655
           +Y  D  +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++VD  + A Y 
Sbjct: 590 KYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQ 649

Query: 656 QTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGR 715
           Q +AEW  CE +VRQRERE+H A   K SSG+S+DSH+ R++HRDSTISN+         
Sbjct: 650 QVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISND--------- 700

Query: 716 QNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEK-QPKIPNGNLVNGTC----------- 763
                         VF SVD++E  E +   + + +P+   G    GT            
Sbjct: 701 --------------VFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFD 746

Query: 764 SPDSGHPSSHNFS------SGLSEHSEPSLSTEDSVLDAQRNTP-----TVLRPRDGSVD 812
           SPDSG PSS N+S      S L E        ED   +   + P     T+  P+D S +
Sbjct: 747 SPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQE 806

Query: 813 DRQSSEATTSQDEA 826
             Q+ E    ++ A
Sbjct: 807 KPQAGELEAGEELA 820



 Score =  406 bits (1043), Expect = e-113
 Identities = 212/394 (53%), Positives = 266/394 (67%), Gaps = 26/394 (6%)

Query: 769  HPSSHN-FSSGLSE--------HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819
            HP++   FSSG S         H + ++S +  +       P    P D      Q +  
Sbjct: 670  HPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGP 729

Query: 820  TTSQDEAPREELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRS 874
             T       ++ +V+ DS +S L ++ +      I  SLD    +   E+D    EG   
Sbjct: 730  GTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSG 789

Query: 875  SETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTV 934
                 H   + +D   E+P+   L       AV  +A            Y+ ELLD   +
Sbjct: 790  PGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVAL 837

Query: 935  NLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 994
            NLHRI+KDVQRCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD+
Sbjct: 838  NLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDN 897

Query: 995  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
            + LA+SCF+ LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY
Sbjct: 898  DQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 957

Query: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
            RWFLLDFKREL+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDI
Sbjct: 958  RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 1017

Query: 1115 IKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 1148
            IKFFNE AE H+ +++L++ARDLV+KVQ LIENK
Sbjct: 1018 IKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1051


>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 1006

 Score =  829 bits (2141), Expect = 0.0
 Identities = 455/849 (53%), Positives = 555/849 (65%), Gaps = 105/849 (12%)

Query: 6   AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
           AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 4   AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63

Query: 66  RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
           RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 64  RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123

Query: 123 PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
           P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 124 PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183

Query: 183 TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGS-MDDRPSLSA 241
           TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 184 TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243

Query: 242 RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
           R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 244 RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303

Query: 302 GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
           GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 304 GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362

Query: 362 FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
           FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 363 FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVD--MEEMGTGRATDYVFRI 420

Query: 422 IYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPK 481
           IYPG + E  A D +         PAW + P      + ++GS                 
Sbjct: 421 IYPGHRHEHNAGDMIEMQGFGPSLPAWHLEP------LCSQGS----------------- 457

Query: 482 EQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTN-GCNHERAPLKLLCD 540
                                       SC SCS S S   + ++  C  +R PL+LLC+
Sbjct: 458 ----------------------------SCLSCSSSSSPHATPSHCSCIPDRLPLRLLCE 489

Query: 541 NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
           +MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W +Y  D
Sbjct: 490 SMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKD 549

Query: 601 STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660
             +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++VD  + A Y Q +AE
Sbjct: 550 KKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAE 609

Query: 661 WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720
           W  CE +VRQRERE+H A   K SSG+S+DSH+ R++HRDSTISN+              
Sbjct: 610 WKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISND-------------- 655

Query: 721 HSDSSSSTQVFESVDEVEQVEAEGRLEEK-QPKIPNGNLVNGTC-----------SPDSG 768
                    VF SVD++E  E +   + + +P+   G    GT            SPDSG
Sbjct: 656 ---------VFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSG 706

Query: 769 HPSSHNFS------SGLSEHSEPSLSTEDSVLDAQRNTP-----TVLRPRDGSVDDRQSS 817
            PSS N+S      S L E        ED   +   + P     T+  P+D S +  Q+ 
Sbjct: 707 LPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAG 766

Query: 818 EATTSQDEA 826
           E    ++ A
Sbjct: 767 ELEAGEELA 775



 Score =  406 bits (1043), Expect = e-113
 Identities = 212/394 (53%), Positives = 266/394 (67%), Gaps = 26/394 (6%)

Query: 769  HPSSHN-FSSGLSE--------HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819
            HP++   FSSG S         H + ++S +  +       P    P D      Q +  
Sbjct: 625  HPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGP 684

Query: 820  TTSQDEAPREELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRS 874
             T       ++ +V+ DS +S L ++ +      I  SLD    +   E+D    EG   
Sbjct: 685  GTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSG 744

Query: 875  SETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTV 934
                 H   + +D   E+P+   L       AV  +A            Y+ ELLD   +
Sbjct: 745  PGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVAL 792

Query: 935  NLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 994
            NLHRI+KDVQRCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD+
Sbjct: 793  NLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDN 852

Query: 995  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
            + LA+SCF+ LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY
Sbjct: 853  DQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 912

Query: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
            RWFLLDFKREL+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDI
Sbjct: 913  RWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDI 972

Query: 1115 IKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 1148
            IKFFNE AE H+ +++L++ARDLV+KVQ LIENK
Sbjct: 973  IKFFNERAEHHDAQEILRIARDLVHKVQMLIENK 1006


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score =  125 bits (314), Expect = 2e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 939  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 402  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461

Query: 996  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 462  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520

Query: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 521  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578

Query: 1115 IKFFNEMAERHNTKQVL 1131
            +K  NE++ + + + +L
Sbjct: 579  LKHINELSMKIDVEDIL 595



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)

Query: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 670
           ++I+ GG+   +RK  W FLLG++ +  T+ ER ++ +Q    Y +   +W   ++I ++
Sbjct: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 387

Query: 671 RERES 675
           +E+ +
Sbjct: 388 QEKRN 392


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score =  125 bits (314), Expect = 2e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 939  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 416  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 475

Query: 996  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 476  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 534

Query: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 535  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 592

Query: 1115 IKFFNEMAERHNTKQVL 1131
            +K  NE++ + + + +L
Sbjct: 593  LKHINELSMKIDVEDIL 609



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)

Query: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 670
           ++I+ GG+   +RK  W FLLG++ +  T+ ER ++ +Q    Y +   +W   ++I ++
Sbjct: 345 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 401

Query: 671 RERES 675
           +E+ +
Sbjct: 402 QEKRN 406


>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score =  125 bits (314), Expect = 2e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 939  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492

Query: 996  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551

Query: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 552  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609

Query: 1115 IKFFNEMAERHNTKQVL 1131
            +K  NE++ + + + +L
Sbjct: 610  LKHINELSMKIDVEDIL 626



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 18/65 (27%), Positives = 39/65 (60%), Gaps = 3/65 (4%)

Query: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQ 670
           ++I+ GG+   +RK  W FLLG++ +  T+ ER ++ +Q    Y +   +W   ++I ++
Sbjct: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQW---KSISQE 418

Query: 671 RERES 675
           +E+ +
Sbjct: 419 QEKRN 423


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score =  120 bits (301), Expect = 7e-27
 Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%)

Query: 913  EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 968
            E S +    ++ +PE    +  N+   ++KDV R DRN  +F      N+E +R I+ +Y
Sbjct: 461  EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520

Query: 969  IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 1027
               +  +GY QGM DL+AP+L  + DE+  F CF  LM+  +  + P    M+     +R
Sbjct: 521  AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580

Query: 1028 SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 1086
             L+++     ++ L+    D     FC+RW LL FKRE    +   +WE  WA  H  + 
Sbjct: 581  ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638

Query: 1087 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1144
            ++ LFI +A+V +Y D ++E  +    ++  F  +A   N + VL+ AR L+Y+ + L
Sbjct: 639  YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696



 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 24/64 (37%), Positives = 35/64 (54%), Gaps = 1/64 (1%)

Query: 594 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHA 652
           W  +L++    EE+  LR  I++GGI   IR  VWPFLL +Y    T  ER+ +  Q   
Sbjct: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRK 460

Query: 653 CYAQ 656
            Y++
Sbjct: 461 EYSE 464



 Score = 34.3 bits (77), Expect = 0.70
 Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%)

Query: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294
           ++Y KNNV V P + ++ +    PGYL L+   D M      L W PN
Sbjct: 37  IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84


>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score =  118 bits (295), Expect = 4e-26
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%)

Query: 939  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 995
            IE+DV R DR N +Y  P N  L  L +I+ +Y   H ++GYVQGM DLL+P+L ++ +E
Sbjct: 375  IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434

Query: 996  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 1054
              AF CF   M+ +  NF      M      +  L+++LD  L + +  + D     FC+
Sbjct: 435  VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493

Query: 1055 RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114
            RW L+ FKRE  + DV  +WE +W      + H  L +A A++++ RD ++ +     +I
Sbjct: 494  RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551

Query: 1115 IKFFNEMAERHNTKQVLKLARDL 1137
            +K  NE+  + + + VL  A  L
Sbjct: 552  LKHINELTMKLSVEDVLTRAEAL 574



 Score = 37.7 bits (86), Expect = 0.063
 Identities = 26/105 (24%), Positives = 49/105 (46%), Gaps = 14/105 (13%)

Query: 577 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 635
           + P    + G  +T   W +++      ++  EL   I+ GG+ P +R+  W FLLG+  
Sbjct: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328

Query: 636 FGMTETE-----RKEVDEQIHACYAQTMAEWLGCEAIVRQRERES 675
           +  T  E     RK+ DE     Y +   +W   +++  ++ER +
Sbjct: 329 WEGTAEEHKAHIRKKTDE-----YFRMKLQW---KSVSPEQERRN 365


>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
          Length = 688

 Score =  107 bits (268), Expect = 5e-23
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 941  KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 996
            KDV R DR + Y+       +L  L +++ +Y   H ++ Y QGM DL +P+L ++D E 
Sbjct: 290  KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349

Query: 997  LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 1055
             AF CF  +MKR+  NF P G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 350  HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408

Query: 1056 WFLLDFKRELVYDDVFLVWETIWAA 1080
            W LL+ KRE  +DD   + E  W++
Sbjct: 409  WLLLELKREFAFDDALRMLEVTWSS 433



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 26/66 (39%), Positives = 37/66 (56%), Gaps = 1/66 (1%)

Query: 597 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYA 655
           YL+        E LRL IY+GG++P +RK VW +LL  Y  G+T  ER +  ++    Y 
Sbjct: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYE 266

Query: 656 QTMAEW 661
           Q  +EW
Sbjct: 267 QLKSEW 272



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 16/50 (32%), Positives = 33/50 (66%)

Query: 1088 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1137
            ++LF+ LA++  +RD I+ N +D+ ++   F+ +  +H+  +VL+ AR L
Sbjct: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666


>gi|34147456 TBC domain-containing protein kinase-like [Homo sapiens]
          Length = 830

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%)

Query: 938  RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 995
            +IE D+ RC + +    +P    K R ++ +++  H ++ Y QG+  L AP L +  ++E
Sbjct: 441  QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500

Query: 996  ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 1052
            ALA++C +  + +   NF    +   +  +      +I   D EL   +++ G     Y 
Sbjct: 501  ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559

Query: 1053 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 1112
               WFL  F        +F +W+T+     + ++ +   I +A+++  RD +L N   F 
Sbjct: 560  AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613

Query: 1113 DIIKFFNEMAE 1123
            + I  F+++ E
Sbjct: 614  ECILLFSDLPE 624


>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
          Length = 917

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 40/143 (27%), Positives = 71/143 (49%), Gaps = 5/143 (3%)

Query: 938  RIEKDVQRCDRNYWYFT-PANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 994
            +IE D+ R   N  +FT P +   +KLR ++ ++ WQ+  IGY QG+  L A  L++L++
Sbjct: 669  QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728

Query: 995  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDY--THFYF 1052
            E  AF C   +++ +     +   +     + R L  +L  +L  LM   G +       
Sbjct: 729  EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788

Query: 1053 CYRWFLLDFKRELVYDDVFLVWE 1075
             + WFL+ F   L+ + +  VW+
Sbjct: 789  TFNWFLVVFADSLISNILLRVWD 811



 Score = 31.2 bits (69), Expect = 5.9
 Identities = 10/21 (47%), Positives = 17/21 (80%)

Query: 592 RIWEQYLHDSTSYEEQELLRL 612
           R+W+ +L++ T Y E+E+LRL
Sbjct: 808 RVWDAFLYEGTKYNEKEILRL 828


>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
           sapiens]
          Length = 641

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 50/181 (27%), Positives = 82/181 (45%), Gaps = 30/181 (16%)

Query: 1   MASAPAEAETRQRLLRTVKKEVKQIMEEAVT-RKFVHEDSSHIISFCAAVEACVLHGLRR 59
           +A+    A  R  LL   K  +K ++E A++  + +  D   +  F   +E C+ HGL+ 
Sbjct: 36  LATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 95

Query: 60  RAAGFLRSNK-IAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKL 118
           R + FL  NK I      V K +P AE++   V+DL  L                     
Sbjct: 96  RKS-FLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL--------------------- 133

Query: 119 PNLSPLAIKHLWIRTALFEKVLDKIVHYLV---ENSSKYYEKEALLMDPVDGPILASLLV 175
              +PL     W+R AL +K +   +  L+   +  S++YE  AL+M+  +G ++  LLV
Sbjct: 134 --KTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEE-EGAVIVGLLV 190

Query: 176 G 176
           G
Sbjct: 191 G 191


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 49/197 (24%), Positives = 89/197 (45%), Gaps = 21/197 (10%)

Query: 956  ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD----------EALAFSCFTEL 1005
            A+ E +  I+  Y   +  I YVQGM +++ PL                EA  F CFT L
Sbjct: 206  AHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNL 265

Query: 1006 MKRMNQNFPHG-----GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLD 1060
            M  +  NF          +      + S ++  D EL+ L  Q  +    +F +RW  L 
Sbjct: 266  MAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELY-LKLQEQNIKPQFFAFRWLTLL 324

Query: 1061 FKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNE 1120
              +E +  DV  +W++++A    +   ++L +  A++ + R+ +LE   DFT  ++   +
Sbjct: 325  LSQEFLLPDVIRIWDSLFADD--NRFDFLLLVCCAMLMLIREQLLEG--DFTVNMRLLQD 380

Query: 1121 MAERHNTKQVLKLARDL 1137
                 +  Q+L+ A++L
Sbjct: 381  YPIT-DVCQILQKAKEL 396


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 45/188 (23%), Positives = 88/188 (46%), Gaps = 12/188 (6%)

Query: 938  RIEKDVQRC---DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 994
            +IE D+ R    +++Y   T   ++KLRN++ ++ W++ +IGY QG+  L+A  L+ L+ 
Sbjct: 709  QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768

Query: 995  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--F 1052
            E  AF C   +++       +   +     + R    ++  +L  L      Y   Y   
Sbjct: 769  ED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLI 827

Query: 1053 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDII--LENNMD 1110
             + WFL+ F   +V D +F +W++            +   ALAL +   + I  L+++M 
Sbjct: 828  TFNWFLVVFVDSVVSDILFKIWDSFL----YEGPKVIFRFALALFKYKEEEILKLQDSMS 883

Query: 1111 FTDIIKFF 1118
                +++F
Sbjct: 884  IFKYLRYF 891


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 45/188 (23%), Positives = 88/188 (46%), Gaps = 12/188 (6%)

Query: 938  RIEKDVQRC---DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 994
            +IE D+ R    +++Y   T   ++KLRN++ ++ W++ +IGY QG+  L+A  L+ L+ 
Sbjct: 709  QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768

Query: 995  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--F 1052
            E  AF C   +++       +   +     + R    ++  +L  L      Y   Y   
Sbjct: 769  ED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLI 827

Query: 1053 CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDII--LENNMD 1110
             + WFL+ F   +V D +F +W++            +   ALAL +   + I  L+++M 
Sbjct: 828  TFNWFLVVFVDSVVSDILFKIWDSFL----YEGPKVIFRFALALFKYKEEEILKLQDSMS 883

Query: 1111 FTDIIKFF 1118
                +++F
Sbjct: 884  IFKYLRYF 891


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 30/248 (12%)

Query: 887  DNLSEEPEMESLFPALA-----SLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEK 941
            + L+  PE+  +F + A     S + T+S N+   VS +    S EL+ L          
Sbjct: 500  NELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKL---------- 549

Query: 942  DVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAF 999
            D+ R   + + F       + L +I+ +Y     ++GYVQGM   +A +L++  +EA AF
Sbjct: 550  DISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLEEADAF 608

Query: 1000 SCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 1055
              F  L+ +  Q       H   M  +FA      +   S+LF L  ++   T   +   
Sbjct: 609  IAFANLLNKPCQLAFFRVDH-SMMLKYFATFEVFFEENLSKLF-LHFKSYSLTPDIYLID 666

Query: 1056 WFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDII 1115
            W    + + L  D    VW+            ++    L ++ +Y DI+L+  MDF  I 
Sbjct: 667  WIFTLYSKSLPLDLACRVWDVFCR----DGEEFLFRTGLGILRLYEDILLQ--MDFIHIA 720

Query: 1116 KFFNEMAE 1123
            +F  ++ E
Sbjct: 721  QFLTKLPE 728


>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%)

Query: 9   ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67
           E R  L+  +K  +K +++ A++  + +  D + +  F   +E C+ HGL+ + + F+  
Sbjct: 3   EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 61

Query: 68  NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127
           NK           F P E           L+E    +   +  +VR LP+L   + +   
Sbjct: 62  NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 99

Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176
             W+  AL +K L   +  L++N    S++YE EAL+M+  +G ++  LLVG
Sbjct: 100 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 150


>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%)

Query: 9   ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67
           E R  L+  +K  +K +++ A++  + +  D + +  F   +E C+ HGL+ + + F+  
Sbjct: 3   EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 61

Query: 68  NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127
           NK           F P E           L+E    +   +  +VR LP+L   + +   
Sbjct: 62  NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 99

Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176
             W+  AL +K L   +  L++N    S++YE EAL+M+  +G ++  LLVG
Sbjct: 100 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 150


>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
           sapiens]
          Length = 708

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%)

Query: 9   ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67
           E R  L+  +K  +K +++ A++  + +  D + +  F   +E C+ HGL+ + + F+  
Sbjct: 111 EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 169

Query: 68  NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127
           NK           F P E           L+E    +   +  +VR LP+L   + +   
Sbjct: 170 NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 207

Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176
             W+  AL +K L   +  L++N    S++YE EAL+M+  +G ++  LLVG
Sbjct: 208 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 258


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 51/223 (22%), Positives = 88/223 (39%), Gaps = 1/223 (0%)

Query: 675 SHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESV 734
           S+++  +  S   S DS+         + S++SS S SS   N    SDSS S+   +S 
Sbjct: 558 SNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS 617

Query: 735 DEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVL 794
           D  +      + E       + +  + + S DS   S  + SS  S  S+ S S++ S  
Sbjct: 618 DSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDS 677

Query: 795 DAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSIT 854
            +  ++       D S D   SSE++ S D +  +     DS  S+   ++S +   S  
Sbjct: 678 SSSSDSSNSSDSSDSS-DSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSD 736

Query: 855 GSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMES 897
            S      +  D       S  ++    +DS D+       +S
Sbjct: 737 SSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDS 779



 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 48/204 (23%), Positives = 88/204 (43%), Gaps = 8/204 (3%)

Query: 700  DSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLV 759
            DS+ S++SS S SS   +    SDSS S+   +S D  +   ++G   +   +  + N  
Sbjct: 808  DSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD--SSDGSDSDSSNRSDSSNSS 865

Query: 760  NGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDS-VLDAQRNTPTVLRPRDGSVDDRQSSE 818
            + + S DS + S  + SS  +E S  S S++ S   D+  +  +       S +   SSE
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925

Query: 819  ATTSQDEAPREELA-VQDSLESDLLANES----MDEFMSITGSLDMALPEKDDVVMEGWR 873
            ++ S D +   + +   DS +S   +N S      +  + + S D    +  D       
Sbjct: 926  SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDS 985

Query: 874  SSETEKHGQADSEDNLSEEPEMES 897
            S  ++    +DS D+ +     +S
Sbjct: 986  SDSSDSSDSSDSSDSSNSSDSSDS 1009



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 44/198 (22%), Positives = 80/198 (40%), Gaps = 2/198 (1%)

Query: 700  DSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLV 759
            DS+ S++SS S  S   N    SDSS+S+   +S D  +  ++            + +  
Sbjct: 955  DSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS-SNSSDSSDSSDSS 1013

Query: 760  NGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819
            + + S DS + S  + SS  S+ S+ S S++ S      ++       D S D   SS++
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS-DSSDSSDS 1072

Query: 820  TTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEK 879
            + S D +   E +      +   +++S D   S   S      +  D       S  ++ 
Sbjct: 1073 SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132

Query: 880  HGQADSEDNLSEEPEMES 897
               +DS ++       ES
Sbjct: 1133 SDSSDSSNSSDSSDSSES 1150



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 42/198 (21%), Positives = 72/198 (36%), Gaps = 4/198 (2%)

Query: 700  DSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLV 759
            DS+ S+ SS S  S   +    SDSS+ +    S D  +  ++    +       N +  
Sbjct: 831  DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890

Query: 760  NGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819
            +   S  S    S +  S  S  S  S ++ DS   +  +  +       S D   SS++
Sbjct: 891  SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950

Query: 820  TTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEK 879
            + S D +   +     S  SD   + S D   S   S      +  D       S+ ++ 
Sbjct: 951  SNSSDSSNSSD----SSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDS 1006

Query: 880  HGQADSEDNLSEEPEMES 897
               +DS D+ +      S
Sbjct: 1007 SDSSDSSDSSNSSDSSNS 1024



 Score = 38.1 bits (87), Expect = 0.048
 Identities = 46/221 (20%), Positives = 83/221 (37%), Gaps = 15/221 (6%)

Query: 700 DSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLV 759
           DS+ S++SS S  S   +    SDS SS        + +  ++    +            
Sbjct: 556 DSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS---------- 605

Query: 760 NGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819
           + + S DS   S  + S   S  SE   S  DS  D+  +  +       S D   SS +
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665

Query: 820 TTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEK 879
           + S D +        DS  S   +N S     S + +   +    D    +   SS++  
Sbjct: 666 SDSSDSSDS-----SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 720

Query: 880 HGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSS 920
              +DS+ + S +    S     +  + ++++++ S  S S
Sbjct: 721 SNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 761



 Score = 37.7 bits (86), Expect = 0.063
 Identities = 43/198 (21%), Positives = 78/198 (39%), Gaps = 6/198 (3%)

Query: 700 DSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLV 759
           +S  S+ S+ S SS   +    SDSSSS+    S D  +  ++     E      + +  
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS-SESSDSSDSSDSD 711

Query: 760 NGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819
           +   S  S   SS + SS  S+ S+ S S++ S      N+         S D   SS++
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS----SDSSDSSDSSNSSDS 767

Query: 820 TTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEK 879
           + S D +   + +          +++S D   S   S      +  D   +   S+ ++ 
Sbjct: 768 SDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD-SSDSDSSNSSDS 826

Query: 880 HGQADSEDNLSEEPEMES 897
              +DS D+ +     +S
Sbjct: 827 SNSSDSSDSSNSSDSSDS 844



 Score = 34.3 bits (77), Expect = 0.70
 Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 9/130 (6%)

Query: 700  DSTISNESSQSC-SSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNL 758
            DS+ S++SS S  SS   +    SDSS S+   +S D  +  ++    +       N   
Sbjct: 1176 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSN--- 1232

Query: 759  VNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQS-- 816
               + S DS   S  + SS  S+ S+ S ST DS  ++   + +     +GS  D  S  
Sbjct: 1233 -ESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEG 1291

Query: 817  --SEATTSQD 824
              S  +TS D
Sbjct: 1292 SDSNHSTSDD 1301



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 41/215 (19%), Positives = 83/215 (38%), Gaps = 1/215 (0%)

Query: 707 SSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPD 766
           +S   S+G  +    SD++SS++   S +  E  +     + K  +  + +  + T + D
Sbjct: 466 NSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSD 525

Query: 767 S-GHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDE 825
           S G+ ++ N  +  S+  +    + DS      N+       D    D  SS  + S D 
Sbjct: 526 SNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS 585

Query: 826 APREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADS 885
              +      S  S+   +    +    + S D +  + D    E   S    K   +DS
Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDS 645

Query: 886 EDNLSEEPEMESLFPALASLAVTTSANEVSPVSSS 920
             + S +    S     ++ + ++ +++ S  SSS
Sbjct: 646 NSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680


>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
          Length = 517

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%)

Query: 938  RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 992
            +I  D+ R         P   E    I+  +  +H   GYVQG+ DL+ P  V+      
Sbjct: 279  QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338

Query: 993  -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 1032
                               + EA  + C ++L+  +  N+      +      +  L+  
Sbjct: 339  EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398

Query: 1033 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 1092
            +D ++   + Q+ +  +  F +RW      RE+       +W+T + ++    +H+ L++
Sbjct: 399  IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456

Query: 1093 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1142
              A +  +R  ILE   DF +++ F   +   H   + + L     Y+++
Sbjct: 457  CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 935  NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 992
            +L  I+ D+ R   N   F       + L +I+ +Y     ++GYVQGM   +A +L++ 
Sbjct: 182  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 240

Query: 993  DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 1048
             D A AF  F+ L+ +  Q       H G M T+FA      +    +LF    +N + T
Sbjct: 241  LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 298

Query: 1049 HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1108
               +   W    + + L  D    +W+            ++   AL +++++ DI+    
Sbjct: 299  PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 352

Query: 1109 MDFTDIIKFFNEMAE 1123
            MDF  + +F   + E
Sbjct: 353  MDFIHMAQFLTRLPE 367


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 935  NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 992
            +L  I+ D+ R   N   F       + L +I+ +Y     ++GYVQGM   +A +L++ 
Sbjct: 462  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 520

Query: 993  DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 1048
             D A AF  F+ L+ +  Q       H G M T+FA      +    +LF    +N + T
Sbjct: 521  LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 578

Query: 1049 HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1108
               +   W    + + L  D    +W+            ++   AL +++++ DI+    
Sbjct: 579  PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 632

Query: 1109 MDFTDIIKFFNEMAE 1123
            MDF  + +F   + E
Sbjct: 633  MDFIHMAQFLTRLPE 647


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 935  NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 992
            +L  I+ D+ R   N   F       + L +I+ +Y     ++GYVQGM   +A +L++ 
Sbjct: 462  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 520

Query: 993  DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 1048
             D A AF  F+ L+ +  Q       H G M T+FA      +    +LF    +N + T
Sbjct: 521  LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 578

Query: 1049 HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1108
               +   W    + + L  D    +W+            ++   AL +++++ DI+    
Sbjct: 579  PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 632

Query: 1109 MDFTDIIKFFNEMAE 1123
            MDF  + +F   + E
Sbjct: 633  MDFIHMAQFLTRLPE 647


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 15/214 (7%)

Query: 927  ELLDLYTVNLHRIEKDVQRCDRNYWYFT----PANLEKLRNIMCSYIWQHIEIGYVQGMC 982
            ELL   T   H I  D+ R    + YF+    P  L  L N++ +Y     E+GY QG+ 
Sbjct: 954  ELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS-LFNLLKAYSLLDKEVGYCQGIS 1012

Query: 983  DLLAPLLVILDDEALAFSCFTELMKRM---NQNFPHGGAMDTHFANMRSLIQILDSELFE 1039
             +   LL+ + +E  AF     LM  +    Q  P   ++      +  L+     +L+ 
Sbjct: 1013 FVAGVLLLHMSEEQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071

Query: 1040 LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEV 1099
             + +N + +   +   WFL  F  +     V  V++ I+    +     +  +AL+L+  
Sbjct: 1072 HLEEN-EISPSLYAAPWFLTLFASQFSLGFVARVFDIIF----LQGTEVIFKVALSLLSS 1126

Query: 1100 YRDIILENNMDFTDIIKFFNEMAERHNTKQVLKL 1133
               +I+E    F +I++F        NT ++ K+
Sbjct: 1127 QETLIMECE-SFENIVEFLKNTLPDMNTSEMEKI 1159


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
            sapiens]
          Length = 815

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 73/332 (21%), Positives = 128/332 (38%), Gaps = 40/332 (12%)

Query: 818  EATTSQDEAPREELAVQDS------LESDLLANESMDEFMSITGSLDMALPEKDDVVMEG 871
            E  + Q E+ +EE     S       + D    ES +E  S TG +    PEK   ++  
Sbjct: 456  EVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEK---ILYS 512

Query: 872  WRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDL 931
            W     + H       NL   P+  S    L    V  +         +G   +  +LD 
Sbjct: 513  WGELLGKWHS------NLGARPKGLS---TLVKSGVPEALRAEVWQLLAGCHDNQAMLDR 563

Query: 932  YTVNLHR-------IEKDVQRCDRNYWYFTPAN---LEKLRNIMCSYIWQHIEIGYVQGM 981
            Y + + +       I +D+ R    + YF        E L  I  +Y     +IGY QG 
Sbjct: 564  YRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQ 623

Query: 982  CDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELM 1041
              L A LL+ + +E  AF    ++M        +    +        L +++  +L +L 
Sbjct: 624  SFLAAVLLLHMPEEQ-AFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLH 682

Query: 1042 HQNGDY---THFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVE 1098
                D     H Y   +WFL  F  +     VF + + +         + +  +ALAL++
Sbjct: 683  SHFSDLNLEAHMY-ASQWFLTLFTAKFPLCMVFHIIDLLLC----EGLNIIFHVALALLK 737

Query: 1099 VYRDIILENNMDFTDIIKFFN-EMAERHNTKQ 1129
              ++ +L+   DF   +KFF  ++ +R+  ++
Sbjct: 738  TSKEDLLQ--ADFEGALKFFRVQLPKRYRAEE 767


>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
          Length = 817

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%)

Query: 939  IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 995
            IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 163  IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222

Query: 996  AL-------------------------AFSCFTELMKRMN---QNFPHGGAMDTH----- 1022
            A                          A++ F++LM+        F H G          
Sbjct: 223  AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282

Query: 1023 --FANMRS-----------------LIQILDSELFELMHQNG-DYTHFYFCYRWFLLDFK 1062
              FA  +                  L++  D EL+  MH N  +     +  RW  L F 
Sbjct: 283  IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELY--MHLNRLEIAPQIYGLRWVRLLFG 340

Query: 1063 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1108
            RE    D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 341  REFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,684,371
Number of Sequences: 37866
Number of extensions: 2201273
Number of successful extensions: 8897
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 98
Number of HSP's that attempted gapping in prelim test: 8695
Number of HSP's gapped (non-prelim): 243
length of query: 1148
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1035
effective length of database: 13,968,660
effective search space: 14457563100
effective search space used: 14457563100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.