Search of human proteins with 90577164

Search of human proteins with 90577164

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo
sapiens]
         (1087 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...  2201   0.0  
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...  2163   0.0  
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...  2039   0.0  
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...  2000   0.0  
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa...  1130   0.0  
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa...  1118   0.0  
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]   125   2e-28
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]   125   2e-28
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]   125   2e-28
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]              120   7e-27
gi|13375952 TBC1 domain family, member 17 [Homo sapiens]              118   3e-26
gi|54607014 TBC1 domain family, member 25 [Homo sapiens]              107   5e-23
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    63   1e-09
gi|222352143 TBC1 domain family, member 2 [Homo sapiens]               58   4e-08
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa...    55   4e-07
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]              54   8e-07
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]    54   8e-07
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]    54   8e-07
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]              54   1e-06
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap...    53   1e-06
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap...    53   1e-06
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap...    53   1e-06
gi|22507409 TBC1 domain family, member 22A [Homo sapiens]              49   3e-05
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]    49   3e-05
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]    49   3e-05
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]    49   3e-05
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               44   6e-04
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...    43   0.002
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]     42   0.004
gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]     42   0.004

>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score = 2201 bits (5704), Expect = 0.0
 Identities = 1087/1087 (100%), Positives = 1087/1087 (100%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP
Sbjct: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
            KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 660
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH
Sbjct: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 660

Query: 661  SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE 720
            SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE
Sbjct: 661  SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE 720

Query: 721  HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL 780
            HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL
Sbjct: 721  HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL 780

Query: 781  LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA 840
            LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA
Sbjct: 781  LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA 840

Query: 841  LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL 900
            LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL
Sbjct: 841  LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL 900

Query: 901  RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT 960
            RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT
Sbjct: 901  RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT 960

Query: 961  HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK 1020
            HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK
Sbjct: 961  HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK 1020

Query: 1021 HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV 1080
            HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV
Sbjct: 1021 HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV 1080

Query: 1081 QTLIENK 1087
            QTLIENK
Sbjct: 1081 QTLIENK 1087


>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score = 2163 bits (5604), Expect = 0.0
 Identities = 1083/1148 (94%), Positives = 1084/1148 (94%), Gaps = 61/1148 (5%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP
Sbjct: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
            KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQ------------ 648
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE  +            
Sbjct: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 660

Query: 649  ---------------------SCSSG----------------------------RQNIRL 659
                                  CSSG                            RQNIRL
Sbjct: 661  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 720

Query: 660  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 719
            HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS
Sbjct: 721  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 780

Query: 720  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 779
            EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD
Sbjct: 781  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 840

Query: 780  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 839
            LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP
Sbjct: 841  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 900

Query: 840  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 899
            ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK
Sbjct: 901  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 960

Query: 900  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 959
            LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD
Sbjct: 961  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 1020

Query: 960  THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1019
            THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA
Sbjct: 1021 THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1080

Query: 1020 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1079
            KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK
Sbjct: 1081 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1140

Query: 1080 VQTLIENK 1087
            VQTLIENK
Sbjct: 1141 VQTLIENK 1148


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
            sapiens]
          Length = 1032

 Score = 2039 bits (5282), Expect = 0.0
 Identities = 1025/1087 (94%), Positives = 1027/1087 (94%), Gaps = 55/1087 (5%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFV  D +     VSV                            + LP    
Sbjct: 421  IIYPGMQSEFVPQDLM----DVSV----------------------------SNLP---- 444

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
                               SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 445  -------------------SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 485

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 486  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 545

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 660
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH
Sbjct: 546  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLH 605

Query: 661  SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE 720
            SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE
Sbjct: 606  SDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSE 665

Query: 721  HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL 780
            HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL
Sbjct: 666  HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDL 725

Query: 781  LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA 840
            LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA
Sbjct: 726  LANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPA 785

Query: 841  LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL 900
            LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL
Sbjct: 786  LASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKL 845

Query: 901  RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT 960
            RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT
Sbjct: 846  RNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDT 905

Query: 961  HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK 1020
            HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK
Sbjct: 906  HFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAK 965

Query: 1021 HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV 1080
            HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV
Sbjct: 966  HVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKV 1025

Query: 1081 QTLIENK 1087
            QTLIENK
Sbjct: 1026 QTLIENK 1032


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score = 2000 bits (5182), Expect = 0.0
 Identities = 1021/1148 (88%), Positives = 1024/1148 (89%), Gaps = 116/1148 (10%)

Query: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60
            MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR
Sbjct: 1    MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRR 60

Query: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120
            AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN
Sbjct: 61   AAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPN 120

Query: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180
            LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL
Sbjct: 121  LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCAL 180

Query: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240
            EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS
Sbjct: 181  EYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLS 240

Query: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300
            ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS
Sbjct: 241  ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGS 300

Query: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360
            VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL
Sbjct: 301  VGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLL 360

Query: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420
            QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR
Sbjct: 361  QFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFR 420

Query: 421  IIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSP 480
            IIYPGMQSEFV  D +     VSV                            + LP    
Sbjct: 421  IIYPGMQSEFVPQDLM----DVSV----------------------------SNLP---- 444

Query: 481  KEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 540
                               SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD
Sbjct: 445  -------------------SLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCD 485

Query: 541  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 600
            NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD
Sbjct: 486  NMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHD 545

Query: 601  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQ------------ 648
            STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE  +            
Sbjct: 546  STSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAE 605

Query: 649  ---------------------SCSSG----------------------------RQNIRL 659
                                  CSSG                            RQNIRL
Sbjct: 606  WLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRL 665

Query: 660  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 719
            HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS
Sbjct: 666  HSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLS 725

Query: 720  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 779
            EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD
Sbjct: 726  EHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESD 785

Query: 780  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 839
            LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP
Sbjct: 786  LLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFP 845

Query: 840  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 899
            ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK
Sbjct: 846  ALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEK 905

Query: 900  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 959
            LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD
Sbjct: 906  LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMD 965

Query: 960  THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1019
            THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA
Sbjct: 966  THFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAA 1025

Query: 1020 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1079
            KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK
Sbjct: 1026 KHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYK 1085

Query: 1080 VQTLIENK 1087
            VQTLIENK
Sbjct: 1086 VQTLIENK 1093


>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1051

 Score = 1130 bits (2922), Expect = 0.0
 Identities = 608/1106 (54%), Positives = 752/1106 (67%), Gaps = 82/1106 (7%)

Query: 6    AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
            AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 4    AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63

Query: 66   RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
            RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 64   RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123

Query: 123  PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
            P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 124  PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183

Query: 183  TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241
            TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 184  TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243

Query: 242  RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
            R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 244  RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303

Query: 302  GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
            GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 304  GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362

Query: 362  FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
            FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 363  FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420

Query: 422  IYPGMQSEFVAPDF--LGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPS 479
            IYPG + E +  ++  L ++ + SV           +ML +              L  P+
Sbjct: 421  IYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMI---------CSRNLTAPN 471

Query: 480  PKEQPPMPQDLMDVSVSNLPSLWQPSP---RKSSCSSCSQSGSADGSSTN-GCNHERAPL 535
            P +      ++     S LP+ W   P   + SSC SCS S S   + ++  C  +R PL
Sbjct: 472  PMKDAGDMIEMQGFGPS-LPA-WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPL 529

Query: 536  KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWE 595
            +LLC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W 
Sbjct: 530  RLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWS 589

Query: 596  QYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQ 655
            +Y  D  +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++     ++  Q
Sbjct: 590  KYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQ 649

Query: 656  NIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHN-F 714
             +               + E +  E   R  E++                  HP++   F
Sbjct: 650  QV---------------LAEWKACEVVVRQRERE-----------------AHPATRTKF 677

Query: 715  SSGLSE--------HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAP 766
            SSG S         H + ++S +  +       P    P D      Q +   T      
Sbjct: 678  SSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVV 737

Query: 767  REELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSETEKHGQ 821
             ++ +V+ DS +S L ++ +      I  SLD    +   E+D    EG        H  
Sbjct: 738  EQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTL 797

Query: 822  ADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKD 881
             + +D   E+P+   L       AV  +A            Y+ ELLD   +NLHRI+KD
Sbjct: 798  REPQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKD 845

Query: 882  VQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCF 941
            VQRCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF
Sbjct: 846  VQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCF 905

Query: 942  TELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK 1001
            + LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK
Sbjct: 906  SHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK 965

Query: 1002 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMA 1061
            REL+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE A
Sbjct: 966  RELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERA 1025

Query: 1062 ERHNTKQVLKLARDLVYKVQTLIENK 1087
            E H+ +++L++ARDLV+KVQ LIENK
Sbjct: 1026 EHHDAQEILRIARDLVHKVQMLIENK 1051


>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 1006

 Score = 1118 bits (2891), Expect = 0.0
 Identities = 602/1104 (54%), Positives = 735/1104 (66%), Gaps = 123/1104 (11%)

Query: 6    AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFL 65
            AE   +++LL  VKKEVKQIMEEAVTRKFVHEDSSHII+ C AVEAC+LH LRRRAAGFL
Sbjct: 4    AEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFL 63

Query: 66   RSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQ---IQGLQENVRKLPKLPNLS 122
            RS+K+AALF KVGK  P A ++  KVQ+L+Q  E  +      + L+       K P LS
Sbjct: 64   RSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALS 123

Query: 123  PLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEY 182
            P A+KH+W+RTAL EKVLDK+V YL EN SKYYEKEALL DPV GPILASLLVGPCALEY
Sbjct: 124  PQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEY 183

Query: 183  TKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSM-DDRPSLSA 241
            TK+KTADH+WTDPSADELVQRHRI     RQDSP KRPAL I+KRHSSGS  +DR +  A
Sbjct: 184  TKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACA 243

Query: 242  RDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSV 301
            R+ VESLHQNSR  LLYGKN+VLVQP++DMEAVPGYLSLHQ+A+ +TLKWTPNQLMNG++
Sbjct: 244  RECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTL 303

Query: 302  GDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQ 361
            GD + EKSVYWDYA+ +   ++V +HCHQQ  SGGT+VLVSQDGIQRPP  FP+GGHLL 
Sbjct: 304  GDSELEKSVYWDYALVVPFSQVVCIHCHQQ-KSGGTLVLVSQDGIQRPPLHFPQGGHLLS 362

Query: 362  FLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRI 421
            FLSCLENGLLP GQL+PPLW+Q+GKGKVFPKLRKRS   S +    +     ATDYVFRI
Sbjct: 363  FLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDM--EEMGTGRATDYVFRI 420

Query: 422  IYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPK 481
            IYPG + E  A                              G   E   +  +LP     
Sbjct: 421  IYPGHRHEHNA------------------------------GDMIEMQGFGPSLPA---- 446

Query: 482  EQPPMPQDLMDVSVSNLPSLWQPSP---RKSSCSSCSQSGSADGSSTN-GCNHERAPLKL 537
                                W   P   + SSC SCS S S   + ++  C  +R PL+L
Sbjct: 447  --------------------WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRL 486

Query: 538  LCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQY 597
            LC++MK QI+SRAFYGWLA+CRHLSTVRTHLSALV+H ++ PD P  A  GLT  +W +Y
Sbjct: 487  LCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKY 546

Query: 598  LHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNI 657
              D  +Y+E ELLR +YYGGI+ EIRK VWPFLLGHY+FGM++ E ++     ++  Q +
Sbjct: 547  QKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQV 606

Query: 658  RLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHN-FSS 716
                           + E +  E   R  E++                  HP++   FSS
Sbjct: 607  ---------------LAEWKACEVVVRQRERE-----------------AHPATRTKFSS 634

Query: 717  GLSE--------HSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPRE 768
            G S         H + ++S +  +       P    P D      Q +   T       +
Sbjct: 635  GSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQ 694

Query: 769  ELAVQ-DSLESDLLANESMDEFMSITGSLD----MALPEKDDVVMEGWRSSETEKHGQAD 823
            + +V+ DS +S L ++ +      I  SLD    +   E+D    EG        H   +
Sbjct: 695  QHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLRE 754

Query: 824  SEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQ 883
             +D   E+P+   L       AV  +A            Y+ ELLD   +NLHRI+KDVQ
Sbjct: 755  PQDPSQEKPQAGELEAGEELAAVCAAA------------YTIELLDTVALNLHRIDKDVQ 802

Query: 884  RCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTE 943
            RCDRNYWYFTP NLE+LR++MCSY+W+H+++GYVQGMCDLLAPLLV LD++ LA+SCF+ 
Sbjct: 803  RCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSH 862

Query: 944  LMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRE 1003
            LMKRM+QNFP+GGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRE
Sbjct: 863  LMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRE 922

Query: 1004 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAER 1063
            L+Y+DVF VWE IWAA+H+SS H+VLFIALALVE YR+II +NNMDFTDIIKFFNE AE 
Sbjct: 923  LLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEH 982

Query: 1064 HNTKQVLKLARDLVYKVQTLIENK 1087
            H+ +++L++ARDLV+KVQ LIENK
Sbjct: 983  HDAQEILRIARDLVHKVQMLIENK 1006


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score =  125 bits (314), Expect = 2e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 878  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 402  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 461

Query: 935  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 462  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 520

Query: 994  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 521  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 578

Query: 1054 IKFFNEMAERHNTKQVL 1070
            +K  NE++ + + + +L
Sbjct: 579  LKHINELSMKIDVEDIL 595



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 17/58 (29%), Positives = 31/58 (53%)

Query: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 668
           ++I+ GG+   +RK  W FLLG++ +  T+ ER +  +  +     ++L   S S  Q
Sbjct: 331 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 388


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score =  125 bits (314), Expect = 2e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 878  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 416  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 475

Query: 935  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 476  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 534

Query: 994  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 535  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 592

Query: 1054 IKFFNEMAERHNTKQVL 1070
            +K  NE++ + + + +L
Sbjct: 593  LKHINELSMKIDVEDIL 609



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 17/58 (29%), Positives = 31/58 (53%)

Query: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 668
           ++I+ GG+   +RK  W FLLG++ +  T+ ER +  +  +     ++L   S S  Q
Sbjct: 345 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 402


>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score =  125 bits (314), Expect = 2e-28
 Identities = 70/197 (35%), Positives = 114/197 (57%), Gaps = 7/197 (3%)

Query: 878  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934
            IEKDV R DR N +Y    N  L  L +I+ +Y     ++GYVQGM DLL+PLL ++++E
Sbjct: 433  IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 492

Query: 935  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993
              AF CF   M +M+QNF      M T    + +L+++LDS     + ++ D  + YFC+
Sbjct: 493  VDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYL-ESQDSGYLYFCF 551

Query: 994  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053
            RW L+ FKRE  + D+  +WE +W     ++ H  L +  A++E  +  I+E +  F +I
Sbjct: 552  RWLLIRFKREFSFLDILRLWEVMWTELPCTNFH--LLLCCAILESEKQQIMEKHYGFNEI 609

Query: 1054 IKFFNEMAERHNTKQVL 1070
            +K  NE++ + + + +L
Sbjct: 610  LKHINELSMKIDVEDIL 626



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 17/58 (29%), Positives = 31/58 (53%)

Query: 611 RLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKESSQSCSSGRQNIRLHSDSSSSTQ 668
           ++I+ GG+   +RK  W FLLG++ +  T+ ER +  +  +     ++L   S S  Q
Sbjct: 362 QMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQ 419


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score =  120 bits (301), Expect = 7e-27
 Identities = 74/238 (31%), Positives = 124/238 (52%), Gaps = 8/238 (3%)

Query: 852  EVSPVSSSGVTYSPELLDLYTVNLH-RIEKDVQRCDRNYWYFTPA---NLEKLRNIMCSY 907
            E S +    ++ +PE    +  N+   ++KDV R DRN  +F      N+E +R I+ +Y
Sbjct: 461  EYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNY 520

Query: 908  IWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKR-MNQNFPHGGAMDTHFANMR 966
               +  +GY QGM DL+AP+L  + DE+  F CF  LM+  +  + P    M+     +R
Sbjct: 521  AVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLR 580

Query: 967  SLIQILDSELFE-LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSA 1025
             L+++     ++ L+    D     FC+RW LL FKRE    +   +WE  WA  H  + 
Sbjct: 581  ELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTD 638

Query: 1026 HYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTL 1083
            ++ LFI +A+V +Y D ++E  +    ++  F  +A   N + VL+ AR L+Y+ + L
Sbjct: 639  YFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 696



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 1/52 (1%)

Query: 594 WEQYLHDSTSYEEQELLR-LIYYGGIQPEIRKAVWPFLLGHYQFGMTETERK 644
           W  +L++    EE+  LR  I++GGI   IR  VWPFLL +Y    T  ER+
Sbjct: 401 WLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEERE 452



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 9/48 (18%)

Query: 256 LLYGKNNVLVQPRDDMEAV----PGYLSLHQTADVM-----TLKWTPN 294
           ++Y KNNV V P + ++ +    PGYL L+   D M      L W PN
Sbjct: 37  IIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPN 84


>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score =  118 bits (295), Expect = 3e-26
 Identities = 69/203 (33%), Positives = 110/203 (54%), Gaps = 7/203 (3%)

Query: 878  IEKDVQRCDR-NYWYFTPAN--LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDE 934
            IE+DV R DR N +Y  P N  L  L +I+ +Y   H ++GYVQGM DLL+P+L ++ +E
Sbjct: 375  IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434

Query: 935  ALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCY 993
              AF CF   M+ +  NF      M      +  L+++LD  L + +  + D     FC+
Sbjct: 435  VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFL-DSQDSGSLCFCF 493

Query: 994  RWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1053
            RW L+ FKRE  + DV  +WE +W      + H  L +A A++++ RD ++ +     +I
Sbjct: 494  RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLH--LLVACAILDMERDTLMLSGFGSNEI 551

Query: 1054 IKFFNEMAERHNTKQVLKLARDL 1076
            +K  NE+  + + + VL  A  L
Sbjct: 552  LKHINELTMKLSVEDVLTRAEAL 574



 Score = 37.0 bits (84), Expect = 0.10
 Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 1/69 (1%)

Query: 577 VSPDLPCDAGQGLTARIWEQYLHDSTSYEE-QELLRLIYYGGIQPEIRKAVWPFLLGHYQ 635
           + P    + G  +T   W +++      ++  EL   I+ GG+ P +R+  W FLLG+  
Sbjct: 269 LGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLS 328

Query: 636 FGMTETERK 644
           +  T  E K
Sbjct: 329 WEGTAEEHK 337


>gi|54607014 TBC1 domain family, member 25 [Homo sapiens]
          Length = 688

 Score =  107 bits (268), Expect = 5e-23
 Identities = 54/145 (37%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 880  KDVQRCDRNYWYFTPA----NLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEA 935
            KDV R DR + Y+       +L  L +++ +Y   H ++ Y QGM DL +P+L ++D E 
Sbjct: 290  KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG 349

Query: 936  LAFSCFTELMKRMNQNF-PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 994
             AF CF  +MKR+  NF P G AM T FA+++ L++  D + ++ + + G     +FCYR
Sbjct: 350  HAFVCFCGIMKRLAANFHPDGRAMATKFAHLKLLLRHADPDFYQYLQEAG-ADDLFFCYR 408

Query: 995  WFLLDFKRELVYDDVFLVWETIWAA 1019
            W LL+ KRE  +DD   + E  W++
Sbjct: 409  WLLLELKREFAFDDALRMLEVTWSS 433



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%)

Query: 597 YLHDSTSYEEQELLRL-IYYGGIQPEIRKAVWPFLLGHYQFGMTETERKE 645
           YL+        E LRL IY+GG++P +RK VW +LL  Y  G+T  ER +
Sbjct: 207 YLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMD 256



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 16/50 (32%), Positives = 33/50 (66%)

Query: 1027 YVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDL 1076
            ++LF+ LA++  +RD I+ N +D+ ++   F+ +  +H+  +VL+ AR L
Sbjct: 617  FMLFLCLAILLEHRDHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 666


>gi|34147456 TBC domain-containing protein kinase-like [Homo sapiens]
          Length = 830

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 46/191 (24%), Positives = 91/191 (47%), Gaps = 12/191 (6%)

Query: 877  RIEKDVQRCDR-NYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVI-LDDE 934
            +IE D+ RC + +    +P    K R ++ +++  H ++ Y QG+  L AP L +  ++E
Sbjct: 441  QIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNE 500

Query: 935  ALAFSCFTELMKRMNQNF---PHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 991
            ALA++C +  + +   NF    +   +  +      +I   D EL   +++ G     Y 
Sbjct: 501  ALAYACMSAFIPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLY- 559

Query: 992  CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFT 1051
               WFL  F        +F +W+T+     + ++ +   I +A+++  RD +L N   F 
Sbjct: 560  AIPWFLTMFTHVFPLHKIFHLWDTLL----LGNSSFPFCIGVAILQQLRDRLLANG--FN 613

Query: 1052 DIIKFFNEMAE 1062
            + I  F+++ E
Sbjct: 614  ECILLFSDLPE 624


>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
          Length = 917

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 40/143 (27%), Positives = 71/143 (49%), Gaps = 5/143 (3%)

Query: 877  RIEKDVQRCDRNYWYFT-PANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 933
            +IE D+ R   N  +FT P +   +KLR ++ ++ WQ+  IGY QG+  L A  L++L++
Sbjct: 669  QIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEE 728

Query: 934  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDY--THFYF 991
            E  AF C   +++ +     +   +     + R L  +L  +L  LM   G +       
Sbjct: 729  EESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788

Query: 992  CYRWFLLDFKRELVYDDVFLVWE 1014
             + WFL+ F   L+ + +  VW+
Sbjct: 789  TFNWFLVVFADSLISNILLRVWD 811



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 10/21 (47%), Positives = 17/21 (80%)

Query: 592 RIWEQYLHDSTSYEEQELLRL 612
           R+W+ +L++ T Y E+E+LRL
Sbjct: 808 RVWDAFLYEGTKYNEKEILRL 828


>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
           sapiens]
          Length = 641

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 50/181 (27%), Positives = 82/181 (45%), Gaps = 30/181 (16%)

Query: 1   MASAPAEAETRQRLLRTVKKEVKQIMEEAVT-RKFVHEDSSHIISFCAAVEACVLHGLRR 59
           +A+    A  R  LL   K  +K ++E A++  + +  D   +  F   +E C+ HGL+ 
Sbjct: 36  LATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKV 95

Query: 60  RAAGFLRSNK-IAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKL 118
           R + FL  NK I      V K +P AE++   V+DL  L                     
Sbjct: 96  RKS-FLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGL--------------------- 133

Query: 119 PNLSPLAIKHLWIRTALFEKVLDKIVHYLV---ENSSKYYEKEALLMDPVDGPILASLLV 175
              +PL     W+R AL +K +   +  L+   +  S++YE  AL+M+  +G ++  LLV
Sbjct: 134 --KTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEE-EGAVIVGLLV 190

Query: 176 G 176
           G
Sbjct: 191 G 191


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 49/197 (24%), Positives = 89/197 (45%), Gaps = 21/197 (10%)

Query: 895  ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD----------EALAFSCFTEL 944
            A+ E +  I+  Y   +  I YVQGM +++ PL                EA  F CFT L
Sbjct: 206  AHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNL 265

Query: 945  MKRMNQNFPHG-----GAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLD 999
            M  +  NF          +      + S ++  D EL+ L  Q  +    +F +RW  L 
Sbjct: 266  MAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELY-LKLQEQNIKPQFFAFRWLTLL 324

Query: 1000 FKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNE 1059
              +E +  DV  +W++++A    +   ++L +  A++ + R+ +LE   DFT  ++   +
Sbjct: 325  LSQEFLLPDVIRIWDSLFADD--NRFDFLLLVCCAMLMLIREQLLEG--DFTVNMRLLQD 380

Query: 1060 MAERHNTKQVLKLARDL 1076
                 +  Q+L+ A++L
Sbjct: 381  YPIT-DVCQILQKAKEL 396


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 45/188 (23%), Positives = 88/188 (46%), Gaps = 12/188 (6%)

Query: 877  RIEKDVQRC---DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 933
            +IE D+ R    +++Y   T   ++KLRN++ ++ W++ +IGY QG+  L+A  L+ L+ 
Sbjct: 709  QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768

Query: 934  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--F 991
            E  AF C   +++       +   +     + R    ++  +L  L      Y   Y   
Sbjct: 769  ED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLI 827

Query: 992  CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDII--LENNMD 1049
             + WFL+ F   +V D +F +W++            +   ALAL +   + I  L+++M 
Sbjct: 828  TFNWFLVVFVDSVVSDILFKIWDSFL----YEGPKVIFRFALALFKYKEEEILKLQDSMS 883

Query: 1050 FTDIIKFF 1057
                +++F
Sbjct: 884  IFKYLRYF 891


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 45/188 (23%), Positives = 88/188 (46%), Gaps = 12/188 (6%)

Query: 877  RIEKDVQRC---DRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 933
            +IE D+ R    +++Y   T   ++KLRN++ ++ W++ +IGY QG+  L+A  L+ L+ 
Sbjct: 709  QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768

Query: 934  EALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFY--F 991
            E  AF C   +++       +   +     + R    ++  +L  L      Y   Y   
Sbjct: 769  ED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLI 827

Query: 992  CYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDII--LENNMD 1049
             + WFL+ F   +V D +F +W++            +   ALAL +   + I  L+++M 
Sbjct: 828  TFNWFLVVFVDSVVSDILFKIWDSFL----YEGPKVIFRFALALFKYKEEEILKLQDSMS 883

Query: 1050 FTDIIKFF 1057
                +++F
Sbjct: 884  IFKYLRYF 891


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 61/248 (24%), Positives = 106/248 (42%), Gaps = 30/248 (12%)

Query: 826  DNLSEEPEMESLFPALA-----SLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEK 880
            + L+  PE+  +F + A     S + T+S N+   VS +    S EL+ L          
Sbjct: 500  NELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKL---------- 549

Query: 881  DVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAF 938
            D+ R   + + F       + L +I+ +Y     ++GYVQGM   +A +L++  +EA AF
Sbjct: 550  DISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLEEADAF 608

Query: 939  SCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYR 994
              F  L+ +  Q       H   M  +FA      +   S+LF L  ++   T   +   
Sbjct: 609  IAFANLLNKPCQLAFFRVDH-SMMLKYFATFEVFFEENLSKLF-LHFKSYSLTPDIYLID 666

Query: 995  WFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDII 1054
            W    + + L  D    VW+            ++    L ++ +Y DI+L+  MDF  I 
Sbjct: 667  WIFTLYSKSLPLDLACRVWDVFCR----DGEEFLFRTGLGILRLYEDILLQ--MDFIHIA 720

Query: 1055 KFFNEMAE 1062
            +F  ++ E
Sbjct: 721  QFLTKLPE 728


>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%)

Query: 9   ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67
           E R  L+  +K  +K +++ A++  + +  D + +  F   +E C+ HGL+ + + F+  
Sbjct: 3   EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 61

Query: 68  NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127
           NK           F P E           L+E    +   +  +VR LP+L   + +   
Sbjct: 62  NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 99

Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176
             W+  AL +K L   +  L++N    S++YE EAL+M+  +G ++  LLVG
Sbjct: 100 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 150


>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%)

Query: 9   ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67
           E R  L+  +K  +K +++ A++  + +  D + +  F   +E C+ HGL+ + + F+  
Sbjct: 3   EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 61

Query: 68  NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127
           NK           F P E           L+E    +   +  +VR LP+L   + +   
Sbjct: 62  NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 99

Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176
             W+  AL +K L   +  L++N    S++YE EAL+M+  +G ++  LLVG
Sbjct: 100 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 150


>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
           sapiens]
          Length = 708

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 28/172 (16%)

Query: 9   ETRQRLLRTVKKEVKQIMEEAVTR-KFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRS 67
           E R  L+  +K  +K +++ A++  + +  D + +  F   +E C+ HGL+ + + F+  
Sbjct: 111 EERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKS-FIGQ 169

Query: 68  NKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIK 127
           NK           F P E           L+E    +   +  +VR LP+L   + +   
Sbjct: 170 NK---------SFFGPLE-----------LVEKLCPEASDIATSVRNLPELK--TAVGRG 207

Query: 128 HLWIRTALFEKVLDKIVHYLVENS---SKYYEKEALLMDPVDGPILASLLVG 176
             W+  AL +K L   +  L++N    S++YE EAL+M+  +G ++  LLVG
Sbjct: 208 RAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEE-EGMVIVGLLVG 258


>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
          Length = 517

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 44/230 (19%), Positives = 91/230 (39%), Gaps = 28/230 (12%)

Query: 877  RIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL----- 931
            +I  D+ R         P   E    I+  +  +H   GYVQG+ DL+ P  V+      
Sbjct: 279  QIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYI 338

Query: 932  -------------------DDEALAFSCFTELMKRMNQNFPHG-GAMDTHFANMRSLIQI 971
                               + EA  + C ++L+  +  N+      +      +  L+  
Sbjct: 339  EAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSR 398

Query: 972  LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFI 1031
            +D ++   + Q+ +  +  F +RW      RE+       +W+T + ++    +H+ L++
Sbjct: 399  IDEQVHRHLDQH-EVRYLQFAFRWMNNLLMREVPLRCTIRLWDT-YQSEPDGFSHFHLYV 456

Query: 1032 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQ 1081
              A +  +R  ILE   DF +++ F   +   H   + + L     Y+++
Sbjct: 457  CAAFLVRWRKEILEEK-DFQELLLFLQNLPTAHWDDEDISLLLAEAYRLK 505


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 874  NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 931
            +L  I+ D+ R   N   F       + L +I+ +Y     ++GYVQGM   +A +L++ 
Sbjct: 182  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 240

Query: 932  DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 987
             D A AF  F+ L+ +  Q       H G M T+FA      +    +LF    +N + T
Sbjct: 241  LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 298

Query: 988  HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047
               +   W    + + L  D    +W+            ++   AL +++++ DI+    
Sbjct: 299  PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 352

Query: 1048 MDFTDIIKFFNEMAE 1062
            MDF  + +F   + E
Sbjct: 353  MDFIHMAQFLTRLPE 367


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 874  NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 931
            +L  I+ D+ R   N   F       + L +I+ +Y     ++GYVQGM   +A +L++ 
Sbjct: 462  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 520

Query: 932  DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 987
             D A AF  F+ L+ +  Q       H G M T+FA      +    +LF    +N + T
Sbjct: 521  LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 578

Query: 988  HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047
               +   W    + + L  D    +W+            ++   AL +++++ DI+    
Sbjct: 579  PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 632

Query: 1048 MDFTDIIKFFNEMAE 1062
            MDF  + +F   + E
Sbjct: 633  MDFIHMAQFLTRLPE 647


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 15/195 (7%)

Query: 874  NLHRIEKDVQRCDRNYWYFTPANL--EKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 931
            +L  I+ D+ R   N   F       + L +I+ +Y     ++GYVQGM   +A +L++ 
Sbjct: 462  SLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILN 520

Query: 932  DDEALAFSCFTELMKRMNQ----NFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYT 987
             D A AF  F+ L+ +  Q       H G M T+FA      +    +LF    +N + T
Sbjct: 521  LDTADAFIAFSNLLNKPCQMAFFRVDH-GLMLTYFAAFEVFFEENLPKLFAHFKKN-NLT 578

Query: 988  HFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047
               +   W    + + L  D    +W+            ++   AL +++++ DI+    
Sbjct: 579  PDIYLIDWIFTLYSKSLPLDLACRIWDVFCR----DGEEFLFRTALGILKLFEDIL--TK 632

Query: 1048 MDFTDIIKFFNEMAE 1062
            MDF  + +F   + E
Sbjct: 633  MDFIHMAQFLTRLPE 647


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 15/214 (7%)

Query: 866  ELLDLYTVNLHRIEKDVQRCDRNYWYFT----PANLEKLRNIMCSYIWQHIEIGYVQGMC 921
            ELL   T   H I  D+ R    + YF+    P  L  L N++ +Y     E+GY QG+ 
Sbjct: 954  ELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLS-LFNLLKAYSLLDKEVGYCQGIS 1012

Query: 922  DLLAPLLVILDDEALAFSCFTELMKRM---NQNFPHGGAMDTHFANMRSLIQILDSELFE 978
             +   LL+ + +E  AF     LM  +    Q  P   ++      +  L+     +L+ 
Sbjct: 1013 FVAGVLLLHMSEEQ-AFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYN 1071

Query: 979  LMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEV 1038
             + +N + +   +   WFL  F  +     V  V++ I+    +     +  +AL+L+  
Sbjct: 1072 HLEEN-EISPSLYAAPWFLTLFASQFSLGFVARVFDIIF----LQGTEVIFKVALSLLSS 1126

Query: 1039 YRDIILENNMDFTDIIKFFNEMAERHNTKQVLKL 1072
               +I+E    F +I++F        NT ++ K+
Sbjct: 1127 QETLIMECE-SFENIVEFLKNTLPDMNTSEMEKI 1159


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
            sapiens]
          Length = 815

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 73/332 (21%), Positives = 128/332 (38%), Gaps = 40/332 (12%)

Query: 757  EATTSQDEAPREELAVQDS------LESDLLANESMDEFMSITGSLDMALPEKDDVVMEG 810
            E  + Q E+ +EE     S       + D    ES +E  S TG +    PEK   ++  
Sbjct: 456  EVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEK---ILYS 512

Query: 811  WRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDL 870
            W     + H       NL   P+  S    L    V  +         +G   +  +LD 
Sbjct: 513  WGELLGKWHS------NLGARPKGLS---TLVKSGVPEALRAEVWQLLAGCHDNQAMLDR 563

Query: 871  YTVNLHR-------IEKDVQRCDRNYWYFTPAN---LEKLRNIMCSYIWQHIEIGYVQGM 920
            Y + + +       I +D+ R    + YF        E L  I  +Y     +IGY QG 
Sbjct: 564  YRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQ 623

Query: 921  CDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELM 980
              L A LL+ + +E  AF    ++M        +    +        L +++  +L +L 
Sbjct: 624  SFLAAVLLLHMPEEQ-AFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLH 682

Query: 981  HQNGDY---THFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVE 1037
                D     H Y   +WFL  F  +     VF + + +         + +  +ALAL++
Sbjct: 683  SHFSDLNLEAHMY-ASQWFLTLFTAKFPLCMVFHIIDLLLC----EGLNIIFHVALALLK 737

Query: 1038 VYRDIILENNMDFTDIIKFFN-EMAERHNTKQ 1068
              ++ +L+   DF   +KFF  ++ +R+  ++
Sbjct: 738  TSKEDLLQ--ADFEGALKFFRVQLPKRYRAEE 767


>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
          Length = 817

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%)

Query: 878  IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 934
            IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 163  IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222

Query: 935  AL-------------------------AFSCFTELMKRMN---QNFPHGGAMDTH----- 961
            A                          A++ F++LM+        F H G          
Sbjct: 223  AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282

Query: 962  --FANMRS-----------------LIQILDSELFELMHQNG-DYTHFYFCYRWFLLDFK 1001
              FA  +                  L++  D EL+  MH N  +     +  RW  L F 
Sbjct: 283  IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELY--MHLNRLEIAPQIYGLRWVRLLFG 340

Query: 1002 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047
            RE    D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 341  REFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384


>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
          Length = 795

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 60/226 (26%)

Query: 878  IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 934
            IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 163  IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222

Query: 935  AL-------------------------AFSCFTELMKRMN---QNFPHGGAMDTH----- 961
            A                          A++ F++LM+        F H G          
Sbjct: 223  AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282

Query: 962  --FANMRS-----------------LIQILDSELFELMHQNG-DYTHFYFCYRWFLLDFK 1001
              FA  +                  L++  D EL+  MH N  +     +  RW  L F 
Sbjct: 283  IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELY--MHLNRLEIAPQIYGLRWVRLLFG 340

Query: 1002 RELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047
            RE    D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 341  REFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,364,049
Number of Sequences: 37866
Number of extensions: 2101130
Number of successful extensions: 8565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 8369
Number of HSP's gapped (non-prelim): 279
length of query: 1087
length of database: 18,247,518
effective HSP length: 113
effective length of query: 974
effective length of database: 13,968,660
effective search space: 13605474840
effective search space used: 13605474840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.