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Search of human proteins with 90403579
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90403579 beta-gamma crystallin domain containing 3 [Homo
sapiens]
(1022 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90403579 beta-gamma crystallin domain containing 3 [Homo sapi... 2091 0.0
gi|62988361 absent in melanoma 1 [Homo sapiens] 449 e-126
gi|89886227 absent in melanoma 1-like [Homo sapiens] 359 6e-99
gi|4503061 crystallin, beta B1 [Homo sapiens] 106 1e-22
gi|4503063 crystallin, beta B2 [Homo sapiens] 106 1e-22
gi|4758074 crystallin, beta B3 [Homo sapiens] 104 4e-22
gi|12056461 crystallin, beta A3 [Homo sapiens] 94 5e-19
gi|16936542 crystallin, beta A2 [Homo sapiens] 89 2e-17
gi|16936540 crystallin, beta A2 [Homo sapiens] 89 2e-17
gi|7019357 crystallin, beta A2 [Homo sapiens] 89 2e-17
gi|4503059 crystallin, beta A4 [Homo sapiens] 89 3e-17
gi|148491074 crystallin, gamma B [Homo sapiens] 85 4e-16
gi|13377002 crystallin, gamma D [Homo sapiens] 82 2e-15
gi|148491057 crystallin, gamma A [Homo sapiens] 82 3e-15
gi|10518338 crystallin, gamma C [Homo sapiens] 81 4e-15
gi|8922120 crystallin, gamma S [Homo sapiens] 74 5e-13
gi|21389517 gammaN-crystallin [Homo sapiens] 72 2e-12
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 41 0.005
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 41 0.005
gi|55741677 SET domain containing 1A [Homo sapiens] 37 0.073
gi|56549656 ARKadia-like 1 isoform b [Homo sapiens] 37 0.073
gi|21450814 ARKadia-like 1 isoform a [Homo sapiens] 37 0.073
gi|188497637 cell division cycle associated 7-like isoform 3 [Ho... 37 0.095
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 37 0.095
gi|31657117 SMEK homolog 1, suppressor of mek1 [Homo sapiens] 37 0.12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 36 0.16
gi|116174736 sentrin/SUMO-specific protease 7 isoform 2 [Homo sa... 35 0.28
gi|4505999 protein phosphatase 1G [Homo sapiens] 35 0.28
gi|29826282 protein phosphatase 1G [Homo sapiens] 35 0.28
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 35 0.36
>gi|90403579 beta-gamma crystallin domain containing 3 [Homo sapiens]
Length = 1022
Score = 2091 bits (5417), Expect = 0.0
Identities = 1022/1022 (100%), Positives = 1022/1022 (100%)
Query: 1 MPDFQPGDTTVRLDKRMSLTAIYDKRRETDYSDKGYNLAFVSQDEQENSSFTILYEEPLQ 60
MPDFQPGDTTVRLDKRMSLTAIYDKRRETDYSDKGYNLAFVSQDEQENSSFTILYEEPLQ
Sbjct: 1 MPDFQPGDTTVRLDKRMSLTAIYDKRRETDYSDKGYNLAFVSQDEQENSSFTILYEEPLQ 60
Query: 61 EEDKYASAEARQTQSVLFHDTSADSMPVLACERSESRTDLVHHFEKGTKLGETFDSDSSE 120
EEDKYASAEARQTQSVLFHDTSADSMPVLACERSESRTDLVHHFEKGTKLGETFDSDSSE
Sbjct: 61 EEDKYASAEARQTQSVLFHDTSADSMPVLACERSESRTDLVHHFEKGTKLGETFDSDSSE 120
Query: 121 MFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSLLQ 180
MFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSLLQ
Sbjct: 121 MFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSLLQ 180
Query: 181 SVSERLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQE 240
SVSERLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQE
Sbjct: 181 SVSERLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQE 240
Query: 241 SVGISKNSYVMPNEPTTSNLQVGLWPEKTSFLQKSDLTSKLHSSLKSAYHQYLQTSQSHS 300
SVGISKNSYVMPNEPTTSNLQVGLWPEKTSFLQKSDLTSKLHSSLKSAYHQYLQTSQSHS
Sbjct: 241 SVGISKNSYVMPNEPTTSNLQVGLWPEKTSFLQKSDLTSKLHSSLKSAYHQYLQTSQSHS 300
Query: 301 SEKGARFGGIFQEPVSKYFRVQDSPGRLSPFIENVDKQTLRCNPRPGKMVIYDLHESTYK 360
SEKGARFGGIFQEPVSKYFRVQDSPGRLSPFIENVDKQTLRCNPRPGKMVIYDLHESTYK
Sbjct: 301 SEKGARFGGIFQEPVSKYFRVQDSPGRLSPFIENVDKQTLRCNPRPGKMVIYDLHESTYK 360
Query: 361 QEVYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRR 420
QEVYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRR
Sbjct: 361 QEVYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRR 420
Query: 421 HPQRNFILGSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSVSFTVKS 480
HPQRNFILGSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSVSFTVKS
Sbjct: 421 HPQRNFILGSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSVSFTVKS 480
Query: 481 GVWLAYPDINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPH 540
GVWLAYPDINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPH
Sbjct: 481 GVWLAYPDINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPH 540
Query: 541 FHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFED 600
FHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFED
Sbjct: 541 FHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFED 600
Query: 601 SNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRS 660
SNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRS
Sbjct: 601 SNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRS 660
Query: 661 IHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHL 720
IHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHL
Sbjct: 661 IHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHL 720
Query: 721 LKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYAD 780
LKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYAD
Sbjct: 721 LKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYAD 780
Query: 781 LTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSV 840
LTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSV
Sbjct: 781 LTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSV 840
Query: 841 WVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQG 900
WVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQG
Sbjct: 841 WVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIKNRAQG 900
Query: 901 EYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVA 960
EYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVA
Sbjct: 901 EYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTPGAKVA 960
Query: 961 LWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGEETQKWDIE 1020
LWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGEETQKWDIE
Sbjct: 961 LWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGEETQKWDIE 1020
Query: 1021 IL 1022
IL
Sbjct: 1021 IL 1022
>gi|62988361 absent in melanoma 1 [Homo sapiens]
Length = 1723
Score = 449 bits (1156), Expect = e-126
Identities = 288/790 (36%), Positives = 429/790 (54%), Gaps = 59/790 (7%)
Query: 275 SDLTSKLHSSLKSAYH--QYLQTSQSHSSEKGARFGGIFQEPVSKYFRVQDSPGRLSPFI 332
S+L+ + ++ A H ++++ + + F G+F+ S+Y P +
Sbjct: 949 SELSKLKNDDMEKANHIESVIKSNLPNCANSDTDFMGLFKS--SRY-----DPSISFSGM 1001
Query: 333 ENVDKQTLR------CNPRPGKMVIYDLHESTYKQ-EVYCNIPDATSWSFPNGVLIKVVR 385
D TLR NPRPGK+VIY + + K EV+ +I D +SWS +LIKVVR
Sbjct: 1002 SLSDTMTLRGSVQNKLNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVR 1061
Query: 386 GCWILYEKPHFRGQKCVLEEGEKVLNRDWILQN--RRHPQ----RNFILGSLKRVLKDCS 439
GCWILYE+P+F G LEEGE L+ W +++ RH + + ++GS++ V++D
Sbjct: 1062 GCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYR 1121
Query: 440 IPEIELFPQSDPACCPVYIQRAVPNLEELN----ISKSVSFTVKSGVWLAYPDINFKGQA 495
+ I+LF + + + + EE+ + K+ S V G WL Y + F+G
Sbjct: 1122 VSHIDLFTEPEGLGI---LSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVP 1178
Query: 496 TVLEE----DHGLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEH 551
+LE D ++ A + S+ PL+MGG KVE P + KV++YEKP F G+ E
Sbjct: 1179 FILEPGEYPDLSFWDTEAAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETG 1238
Query: 552 IDSVPNFLKNNGD-----------FHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFED 600
+ S F+ G+ F +GS++V+ G+WVAYEK F G Q+LLEEG++ D
Sbjct: 1239 MCS---FVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRD 1295
Query: 601 SNACGALSSPILSFRYLQANFIESSVTLF-ESDLES-GKFIDITNQEISDLEEIGFGSKT 658
A G + + S R + +F + + ++ E + S G ID+ +++L+E G+G KT
Sbjct: 1296 WKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGI-VANLKETGYGVKT 1354
Query: 659 RSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPP 718
+SI+V SGVWVAY+ F GEQYIL+KG Y F DWGG N I S++PI L+
Sbjct: 1355 QSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRR 1414
Query: 719 HLLKAFSKPGFQGECIDFTEETSDLT-SLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEGL 777
+ + FS+P FQG F E TS + S S +V G W++Y E+ N VLEEG
Sbjct: 1415 NQIHLFSEPQFQGHSQSFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGH 1474
Query: 778 YADLTSCGCP-ASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLE-EAVNSVLNKDLHF 835
Y L++ GCP + KSL+ ID F EP+I LF E +G+++ L E VN + L F
Sbjct: 1475 YPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNL---RSLGF 1531
Query: 836 YTQ--SVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIR 893
TQ SV V G+W+ YE ++ GRQ LL P E+PNW FS + IGSLRP Q +Y R
Sbjct: 1532 NTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCRQIGSLRPFVQKRIYFR 1591
Query: 894 IKNRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSK-ASDTCLDVIGGR 952
++N+A G +++ G+L D + + + G + QIW Y G K + A D CL ++G
Sbjct: 1592 LRNKATGLFMSTNGNLEDLKLLRIQVMEDVGADDQIWIYQEGCIKCRIAEDCCLTIVGSL 1651
Query: 953 DTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGE 1012
T G+K+ L + Q W L +G I S L LVLD+KGG D+ H+I+N + +
Sbjct: 1652 VTSGSKLGLALDQNADSQFWSLKSDGRIYSKLKPNLVLDIKGGTQYDQNHIILNTVSKEK 1711
Query: 1013 ETQKWDIEIL 1022
TQ W+ +L
Sbjct: 1712 FTQVWEAMVL 1721
>gi|89886227 absent in melanoma 1-like [Homo sapiens]
Length = 616
Score = 359 bits (922), Expect = 6e-99
Identities = 218/607 (35%), Positives = 336/607 (55%), Gaps = 17/607 (2%)
Query: 428 LGSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSV-SFTVKSGVWLAY 486
+GSL+RV+ D S PEI LF + V + A+ N + L V S TV +G+WL Y
Sbjct: 15 IGSLRRVVWDYSTPEISLFSEEGLKGEQVKLTEALKNSQGLEKPLQVASATVSAGLWLLY 74
Query: 487 PDINFKGQATVLEEDH----GLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFH 542
P F+ +LE + S + SL P+++G VE P + ++YE P F
Sbjct: 75 PKPLFEDTPYILEPGEYPTSEAWGTSDPSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQ 134
Query: 543 GQAKEFSEHIDSVPNFLKNNGD-FHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDS 601
G++ E S I ++ + +GS+RV+GG WV YEKE F+G Q+LLEEG++ D
Sbjct: 135 GRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDW 194
Query: 602 NACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSI 661
+ G + S R ++ +F + +V LFE+ G ++++ + + D+E + G T++I
Sbjct: 195 SHWGGYDELLTSLRVIRTDFGDPAVVLFEAMDFEGHGVEVS-KALPDVELVQHGPSTQAI 253
Query: 662 HVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPP--- 718
HV SGVWVAYQ+ F GEQY+LEKG Y+ DWG N+ + S++P+ L + E
Sbjct: 254 HVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDWGAGNSTLASLQPV----LQVGEHDLHF 309
Query: 719 -HLLKAFSKPGFQGECIDFTEETSDL-TSLMPCSFKVLRGCWLLYYQEDMFVNHCVLEEG 776
++ FS+P F G+ F ++ + L S P S +V G W+L+ + + + +L EG
Sbjct: 310 VSKIQLFSRPDFLGDHFSFEDDQAALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEG 369
Query: 777 LYADLTSCGCPASKVK-SLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHF 835
+ LT+ GC AS V SL+ + F EPSI L+ LE EG+E+ L V S+ + +
Sbjct: 370 EFPTLTAMGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFNN 429
Query: 836 YTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQPAVYIRIK 895
+ SV +K G+W+ E S+F GRQ L+ EI NW +S + +GSL P+KQ VY R+
Sbjct: 430 HVLSVRIKGGIWVLCEHSDFRGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQRRVYFRLW 489
Query: 896 NRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFKSKASDTCLDVIGGRDTP 955
N A G +L V + D +A V ++ + IWYY GL K++ + T + G +P
Sbjct: 490 NAALGGFLAVPDHVEDMKAGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSP 549
Query: 956 GAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGNYCDKTHVIVNQPLEGEETQ 1015
G+KV LW E RQ W ++++G I S + + +LDVKGG D+ HV++ +P E +Q
Sbjct: 550 GSKVVLWAESRLPRQTWSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQ 609
Query: 1016 KWDIEIL 1022
W I +L
Sbjct: 610 IWTIHVL 616
Score = 136 bits (342), Expect = 1e-31
Identities = 100/338 (29%), Positives = 172/338 (50%), Gaps = 31/338 (9%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
++V+ GCW+ YEK FRG + +LEEGE DW + +L SL+ + D
Sbjct: 164 LRVLGGCWVGYEKEGFRGHQYLLEEGE---YPDW----SHWGGYDELLTSLRVIRTDFGD 216
Query: 441 PEIELFPQSDPACCPVYIQRAVPNLEELNISKSV-SFTVKSGVWLAYPDINFKGQATVLE 499
P + LF D V + +A+P++E + S + V SGVW+AY ++ F G+ VLE
Sbjct: 217 PAVVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVLE 276
Query: 500 -------EDHGLFEISTAEMKSLHP-LQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEH 551
ED G + + SL P LQ+G + ++ K+ ++ +P F G F +
Sbjct: 277 KGVYRNCEDWG---AGNSTLASLQPVLQVG--EHDLHFVSKIQLFSRPDFLGDHFSFEDD 331
Query: 552 IDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSSPI 611
++P R S RV GG W+ +++ +F+G Q +L EG+F A G L+S +
Sbjct: 332 QAALPASF-------RPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTV 384
Query: 612 L-SFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVA 670
L S + + +F E S+ L+ + GK I++ ++E+ L+ GF + S+ +K G+WV
Sbjct: 385 LGSLQKVSLHFSEPSIFLYGLECFEGKEIEL-SREVRSLQAEGFNNHVLSVRIKGGIWVL 443
Query: 671 YQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQ 708
+ F G Q+++ + + + G+ + S+ PI+
Sbjct: 444 CEHSDFRGRQWLVGSCEITNWLTYSGTQR-VGSLYPIK 480
Score = 86.7 bits (213), Expect = 1e-16
Identities = 99/413 (23%), Positives = 171/413 (41%), Gaps = 60/413 (14%)
Query: 383 VVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSIPE 442
V G W+LY KP F +LE GE + W + +GSLK + C E
Sbjct: 66 VSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSDPS-------VGSLKPMRLGCPSVE 118
Query: 443 IELFPQSDPACCPVY------IQRAVPNLEELNISKSV------SFTVKSGVWLAYPDIN 490
P++ P + + R + NL++ S+S S V G W+ Y
Sbjct: 119 KPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLASVGSLRVLGGCWVGYEKEG 178
Query: 491 FKGQATVLEEDH--------GLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFH 542
F+G +LEE G E+ T+ + ++ + + V+++E F
Sbjct: 179 FRGHQYLLEEGEYPDWSHWGGYDELLTS---------LRVIRTDFG-DPAVVLFEAMDFE 228
Query: 543 GQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSN 602
G E S+ + V L +G + +I V+ GVWVAY++ F G+Q++LE+G + +
Sbjct: 229 GHGVEVSKALPDVE--LVQHGPSTQ--AIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCE 284
Query: 603 ACGALSS------PILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGS 656
GA +S P+L +F+ S + LF G + D +
Sbjct: 285 DWGAGNSTLASLQPVLQVGEHDLHFV-SKIQLFSRPDFLGDHFSFED----DQAALPASF 339
Query: 657 KTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINE 716
+ +S V G W+ + + F G+Q+IL +G++ G + ++ +Q L +E
Sbjct: 340 RPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLG--SLQKVSLHFSE 397
Query: 717 PPHLLKAFSKPGFQGECIDFTEETSDLT----SLMPCSFKVLRGCWLLYYQED 765
P L + F+G+ I+ + E L + S ++ G W+L D
Sbjct: 398 PSIFL--YGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSD 448
Score = 63.5 bits (153), Expect = 9e-10
Identities = 65/228 (28%), Positives = 103/228 (45%), Gaps = 29/228 (12%)
Query: 376 PNGVLIKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVL 435
P+ I V+ G W+ Y++ F G++ VLE+G DW N L SL+ VL
Sbjct: 248 PSTQAIHVLSGVWVAYQEVGFSGEQYVLEKGVYRNCEDW-------GAGNSTLASLQPVL 300
Query: 436 KDCS-----IPEIELFPQSDPACCPVYI---QRAVPNLEELNISKSVSFTVKSGVWLAYP 487
+ + +I+LF + D Q A+P + S V G W+ +
Sbjct: 301 QVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQAALP-----ASFRPQSCRVHGGSWILFD 355
Query: 488 DINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGGL-KVEMPMN-LKVIIYEKPHFHGQA 545
+ NF+G +L E G F TA M L +G L KV + + + +Y F G+
Sbjct: 356 ETNFEGDQHILSE--GEFPTLTA-MGCLASTVLGSLQKVSLHFSEPSIFLYGLECFEGKE 412
Query: 546 KEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLL 593
E S + S L+ G + + S+R+ GG+WV E F+G+Q+L+
Sbjct: 413 IELSREVRS----LQAEGFNNHVLSVRIKGGIWVLCEHSDFRGRQWLV 456
>gi|4503061 crystallin, beta B1 [Homo sapiens]
Length = 252
Score = 106 bits (264), Expect = 1e-22
Identities = 65/201 (32%), Positives = 107/201 (53%), Gaps = 15/201 (7%)
Query: 528 PMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFK 587
P N +++++E +F G+ EFS + L + G F R+ SI V G WVA+E+ +F+
Sbjct: 56 PGNYRLVVFELENFQGRRAEFSGECSN----LADRG-FDRVRSIIVSAGPWVAFEQSNFR 110
Query: 588 GQQFLLEEGDFEDSNACGAL--SSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQE 645
G+ F+LE+G++ N + S ++SFR ++ + E ++LFE G I+I +
Sbjct: 111 GEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDD 170
Query: 646 ISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIR 705
L GF + S+ V SG WV YQ + G QY+LE G ++ + +WG + S+R
Sbjct: 171 APSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLR 230
Query: 706 PIQ-----LE---PLGINEPP 718
++ LE P+ EPP
Sbjct: 231 RLRDKQWHLEGSFPVLATEPP 251
Score = 70.1 bits (170), Expect = 1e-11
Identities = 45/156 (28%), Positives = 79/156 (50%), Gaps = 5/156 (3%)
Query: 464 NLEELNISKSVSFTVKSGVWLAYPDINFKGQATVLEE-DHGLFEISTAEMKSLHPLQMGG 522
NL + + S V +G W+A+ NF+G+ +LE+ ++ + ++ +S +
Sbjct: 82 NLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRP 141
Query: 523 LKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYE 582
+K++ + K+ ++E +F G E D P+ L G R+GS++V G WV Y+
Sbjct: 142 IKMDAQEH-KISLFEGANFKGNTIEIQG--DDAPS-LWVYGFSDRVGSVKVSSGTWVGYQ 197
Query: 583 KEHFKGQQFLLEEGDFEDSNACGALSSPILSFRYLQ 618
++G Q+LLE GDF N GA + S R L+
Sbjct: 198 YPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLR 233
Score = 55.1 bits (131), Expect = 3e-07
Identities = 50/187 (26%), Positives = 79/187 (42%), Gaps = 14/187 (7%)
Query: 717 PP--HLLKAFSKPGFQGECIDFTEETSDLTSL---MPCSFKVLRGCWLLYYQEDMFVNHC 771
PP + L F FQG +F+ E S+L S V G W+ + Q +
Sbjct: 55 PPGNYRLVVFELENFQGRRAEFSGECSNLADRGFDRVRSIIVSAGPWVAFEQSNFRGEMF 114
Query: 772 VLEEGLYA--DLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLE-EAVNSV 828
+LE+G Y + S + ++ S +PI +E ISLF + +G + ++ + S+
Sbjct: 115 ILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDAQEHKISLFEGANFKGNTIEIQGDDAPSL 174
Query: 829 LNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGSLRPMKQP 888
SV V SG W+ Y+ + G Q LL P + F W G+ +P Q
Sbjct: 175 WVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLLEPGD------FRHWNEWGAFQPQMQS 228
Query: 889 AVYIRIK 895
+R K
Sbjct: 229 LRRLRDK 235
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)
Query: 782 TSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVW 841
T+ ++K L P +Y + +F LE+ +GR +++ ++ +S+
Sbjct: 42 TTVPITSAKAAELPPGNY-----RLVVFELENFQGRRAEFSGECSNLADRGFD-RVRSII 95
Query: 842 VKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFS---RWKTIGSLRPMKQPA 889
V +G W+A+E SNF G +L E P W +S R + S RP+K A
Sbjct: 96 VSAGPWVAFEQSNFRGEMFILEKGEYPRWNTWSSSYRSDRLMSFRPIKMDA 146
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/121 (28%), Positives = 54/121 (44%), Gaps = 7/121 (5%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
I V G W+ +E+ +FRG+ +LE+GE W R+ L S + + D
Sbjct: 94 IIVSAGPWVAFEQSNFRGEMFILEKGEYPRWNTW-----SSSYRSDRLMSFRPIKMDAQE 148
Query: 441 PEIELFPQSDPACCPVYIQ-RAVPNLEELNISKSV-SFTVKSGVWLAYPDINFKGQATVL 498
+I LF ++ + IQ P+L S V S V SG W+ Y ++G +L
Sbjct: 149 HKISLFEGANFKGNTIEIQGDDAPSLWVYGFSDRVGSVKVSSGTWVGYQYPGYRGYQYLL 208
Query: 499 E 499
E
Sbjct: 209 E 209
>gi|4503063 crystallin, beta B2 [Homo sapiens]
Length = 205
Score = 106 bits (264), Expect = 1e-22
Identities = 66/199 (33%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 512 MKSLHPLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSI 571
M S H Q G +N K+II+E+ +F G + E + PN LK G + GS+
Sbjct: 1 MASDHQTQAGK---PQSLNPKIIIFEQENFQGHSHELN---GPCPN-LKETG-VEKAGSV 52
Query: 572 RVIGGVWVAYEKEHFKGQQFLLEEGDFE--DSNACGALSSPILSFRYLQANFIESSVTLF 629
V G WV YE+ + KG+QF+ E+G++ DS + + S R ++ + E + L+
Sbjct: 53 LVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILY 112
Query: 630 ESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYK 689
E+ +GK ++I + ++ G+ K S+ V+SG WV YQ + G QY+LEKG YK
Sbjct: 113 ENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYK 172
Query: 690 CFFDWGGSNNIIMSIRPIQ 708
D+G + + S+R I+
Sbjct: 173 DSSDFGAPHPQVQSVRRIR 191
Score = 90.1 bits (222), Expect = 9e-18
Identities = 57/184 (30%), Positives = 94/184 (51%), Gaps = 15/184 (8%)
Query: 441 PEIELFPQSDPACCPVYIQRAVPNLEELNISKSVSFTVKSGVWLAYPDINFKGQATVLEE 500
P+I +F Q + + PNL+E + K+ S V++G W+ Y N KG+ V E+
Sbjct: 17 PKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWVGYEQANCKGEQFVFEK 76
Query: 501 ------DHGLFEISTAEMKSLHPLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDS 554
D T + SL P+++ K+I+YE P+F G+ E + D
Sbjct: 77 GEYPRWDSWTSSRRTDSLSSLRPIKVDS------QEHKIILYENPNFTGKKMEIID--DD 128
Query: 555 VPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSSPILSF 614
VP+F +G ++ S+RV G WV Y+ ++G Q+LLE+GD++DS+ GA + S
Sbjct: 129 VPSF-HAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSV 187
Query: 615 RYLQ 618
R ++
Sbjct: 188 RRIR 191
Score = 64.3 bits (155), Expect = 6e-10
Identities = 49/185 (26%), Positives = 87/185 (47%), Gaps = 18/185 (9%)
Query: 622 IESSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQY 681
+ + +FE + G ++ N +L+E G K S+ V++G WV Y+Q GEQ+
Sbjct: 15 LNPKIIIFEQENFQGHSHEL-NGPCPNLKETGV-EKAGSVLVQAGPWVGYEQANCKGEQF 72
Query: 682 ILEKGKYKCFFDWGGSNNI--IMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEE 739
+ EKG+Y + W S + S+RPI+ ++ H + + P F G+ ++ ++
Sbjct: 73 VFEKGEYPRWDSWTSSRRTDSLSSLRPIK-----VDSQEHKIILYENPNFTGKKMEIIDD 127
Query: 740 TSDLTSLMP-------CSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVK 792
D+ S S +V G W+ Y +LE+G Y D + G P +V+
Sbjct: 128 --DVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQ 185
Query: 793 SLKPI 797
S++ I
Sbjct: 186 SVRRI 190
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 804 PSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLR 863
P I +F E+ +G L ++ + SV V++G W+ YE +N G Q +
Sbjct: 17 PKIIIFEQENFQGHSHELNGPCPNLKETGVE-KAGSVLVQAGPWVGYEQANCKGEQFVFE 75
Query: 864 PNEIP---NWTAFSRWKTIGSLRPMK 886
E P +WT+ R ++ SLRP+K
Sbjct: 76 KGEYPRWDSWTSSRRTDSLSSLRPIK 101
Score = 40.0 bits (92), Expect = 0.011
Identities = 34/129 (26%), Positives = 58/129 (44%), Gaps = 7/129 (5%)
Query: 750 SFKVLRGCWLLYYQEDMFVNHCVLEEGLYA--DLTSCGCPASKVKSLKPIDYVFEEPSIS 807
S V G W+ Y Q + V E+G Y D + + SL+PI +E I
Sbjct: 51 SVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKII 110
Query: 808 LFALEHCEGRELHLEEAVNSVLNKDLHFYTQ---SVWVKSGLWIAYEGSNFLGRQILLRP 864
L+ + G+++ + + + V + H Y + SV V+SG W+ Y+ + G Q LL
Sbjct: 111 LYENPNFTGKKMEIID--DDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEK 168
Query: 865 NEIPNWTAF 873
+ + + F
Sbjct: 169 GDYKDSSDF 177
Score = 35.4 bits (80), Expect = 0.28
Identities = 31/122 (25%), Positives = 53/122 (43%), Gaps = 7/122 (5%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
+ V G W+ YE+ + +G++ V E+GE W R L SL+ + D
Sbjct: 52 VLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDS-----LSSLRPIKVDSQE 106
Query: 441 PEIELFPQSDPACCPV-YIQRAVPNLEELNISKSV-SFTVKSGVWLAYPDINFKGQATVL 498
+I L+ + + I VP+ + V S V+SG W+ Y ++G +L
Sbjct: 107 HKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLL 166
Query: 499 EE 500
E+
Sbjct: 167 EK 168
>gi|4758074 crystallin, beta B3 [Homo sapiens]
Length = 211
Score = 104 bits (260), Expect = 4e-22
Identities = 58/179 (32%), Positives = 99/179 (55%), Gaps = 7/179 (3%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
KVI+YE +F G+ E S S+ + L ++GSI+V G W+A+E F+G+QF
Sbjct: 25 KVILYELENFQGKRCELSAECPSLTDSL-----LEKVGSIQVESGPWLAFESRAFRGEQF 79
Query: 592 LLEEGDFE--DSNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDL 649
+LE+GD+ D+ + S +LS R L + + LFE+ SG+ ++I + ++ L
Sbjct: 80 VLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEIVDDDVPSL 139
Query: 650 EEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQ 708
GF + S+ +G WV Y+ + G QY+ E+G+Y+ + +W S + S+R I+
Sbjct: 140 WAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQLQSVRRIR 198
Score = 72.8 bits (177), Expect = 2e-12
Identities = 48/157 (30%), Positives = 83/157 (52%), Gaps = 5/157 (3%)
Query: 463 PNLEELNISKSVSFTVKSGVWLAYPDINFKGQATVLEE-DHGLFEISTAEMKSLHPLQMG 521
P+L + + K S V+SG WLA+ F+G+ VLE+ D+ ++ + S L +
Sbjct: 46 PSLTDSLLEKVGSIQVESGPWLAFESRAFRGEQFVLEKGDYPRWDAWSNSRDSDSLLSLR 105
Query: 522 GLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAY 581
L ++ P + K+ ++E P F G+ E + D VP+ L +G R+ S+R I G WV Y
Sbjct: 106 PLNIDSPHH-KLHLFENPAFSGRKMEIVD--DDVPS-LWAHGFQDRVASVRAINGTWVGY 161
Query: 582 EKEHFKGQQFLLEEGDFEDSNACGALSSPILSFRYLQ 618
E ++G+Q++ E G++ N A + S R ++
Sbjct: 162 EFPGYRGRQYVFERGEYRHWNEWDASQPQLQSVRRIR 198
Score = 68.9 bits (167), Expect = 2e-11
Identities = 52/183 (28%), Positives = 86/183 (46%), Gaps = 22/183 (12%)
Query: 626 VTLFESDLESGKFIDITNQ--EISD--LEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQY 681
V L+E + GK +++ + ++D LE++G SI V+SG W+A++ + F GEQ+
Sbjct: 26 VILYELENFQGKRCELSAECPSLTDSLLEKVG------SIQVESGPWLAFESRAFRGEQF 79
Query: 682 ILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEETS 741
+LEKG Y + W S + S + L PL I+ P H L F P F G ++ ++
Sbjct: 80 VLEKGDYPRWDAWSNSRD---SDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEIVDD-- 134
Query: 742 DLTSLMP-------CSFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSL 794
D+ SL S + + G W+ Y V E G Y +++S+
Sbjct: 135 DVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDASQPQLQSV 194
Query: 795 KPI 797
+ I
Sbjct: 195 RRI 197
Score = 44.7 bits (104), Expect = 5e-04
Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 6/148 (4%)
Query: 729 FQGECIDFTEETSDLTSLM---PCSFKVLRGCWLLYYQEDMFVNHCVLEEGLYA--DLTS 783
FQG+ + + E LT + S +V G WL + VLE+G Y D S
Sbjct: 34 FQGKRCELSAECPSLTDSLLEKVGSIQVESGPWLAFESRAFRGEQFVLEKGDYPRWDAWS 93
Query: 784 CGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHL-EEAVNSVLNKDLHFYTQSVWV 842
+ + SL+P++ + LF GR++ + ++ V S+ SV
Sbjct: 94 NSRDSDSLLSLRPLNIDSPHHKLHLFENPAFSGRKMEIVDDDVPSLWAHGFQDRVASVRA 153
Query: 843 KSGLWIAYEGSNFLGRQILLRPNEIPNW 870
+G W+ YE + GRQ + E +W
Sbjct: 154 INGTWVGYEFPGYRGRQYVFERGEYRHW 181
Score = 44.3 bits (103), Expect = 6e-04
Identities = 26/83 (31%), Positives = 44/83 (53%), Gaps = 4/83 (4%)
Query: 806 ISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPN 865
+ L+ LE+ +G+ L S+ + L S+ V+SG W+A+E F G Q +L
Sbjct: 26 VILYELENFQGKRCELSAECPSLTDSLLE-KVGSIQVESGPWLAFESRAFRGEQFVLEKG 84
Query: 866 EIPNWTAFSRWK---TIGSLRPM 885
+ P W A+S + ++ SLRP+
Sbjct: 85 DYPRWDAWSNSRDSDSLLSLRPL 107
Score = 35.4 bits (80), Expect = 0.28
Identities = 41/157 (26%), Positives = 66/157 (42%), Gaps = 12/157 (7%)
Query: 348 KMVIYDLHESTYKQ-EVYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLEEG 406
K+++Y+L K+ E+ P T I+V G W+ +E FRG++ VLE+G
Sbjct: 25 KVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQVESGPWLAFESRAFRGEQFVLEKG 84
Query: 407 EKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSIPEIELFPQSDPACC---PVYIQRAVP 463
+ W N R L SL+ + D ++ LF +PA + VP
Sbjct: 85 DYPRWDAW--SNSRDSDS---LLSLRPLNIDSPHHKLHLF--ENPAFSGRKMEIVDDDVP 137
Query: 464 NLEELNISKSV-SFTVKSGVWLAYPDINFKGQATVLE 499
+L V S +G W+ Y ++G+ V E
Sbjct: 138 SLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFE 174
Score = 34.3 bits (77), Expect = 0.62
Identities = 21/70 (30%), Positives = 36/70 (51%), Gaps = 8/70 (11%)
Query: 366 NIPDATSWSFPNGVL-IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQR 424
++P + F + V ++ + G W+ YE P +RG++ V E GE R W + PQ
Sbjct: 135 DVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGE---YRHWNEWDASQPQ- 190
Query: 425 NFILGSLKRV 434
L S++R+
Sbjct: 191 ---LQSVRRI 197
>gi|12056461 crystallin, beta A3 [Homo sapiens]
Length = 215
Score = 94.4 bits (233), Expect = 5e-19
Identities = 65/189 (34%), Positives = 105/189 (55%), Gaps = 18/189 (9%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ IY++ +F G+ EF+ S PN + + F + S++V G W+ YE F GQQF
Sbjct: 32 KITIYDQENFQGKRMEFTS---SCPNVSERS--FDNVRSLKVESGAWIGYEHTSFCGQQF 86
Query: 592 LLEEGDFEDSNACGALSS----PILSFRYL-QANFIESSVTLFESDLESGKFIDITNQEI 646
+LE G++ +A ++ ++SFR + AN ES +T+FE + G+ +I++ +
Sbjct: 87 ILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISD-DY 145
Query: 647 SDLEEIG-FGSKTRSIHVKSGVWVAYQQKFFCGEQYILE----KGKYKCFFDWG--GSNN 699
L+ +G F ++ S+ ++SG WV YQ + G QYILE G YK + +WG +
Sbjct: 146 PSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTS 205
Query: 700 IIMSIRPIQ 708
I SIR IQ
Sbjct: 206 QIQSIRRIQ 214
Score = 69.7 bits (169), Expect = 1e-11
Identities = 51/187 (27%), Positives = 89/187 (47%), Gaps = 21/187 (11%)
Query: 626 VTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEK 685
+T+++ + GK ++ T+ ++ E F + RS+ V+SG W+ Y+ FCG+Q+ILE+
Sbjct: 33 ITIYDQENFQGKRMEFTSS-CPNVSERSFDN-VRSLKVESGAWIGYEHTSFCGQQFILER 90
Query: 686 GKYKCFFDWGGSN----NIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEETS 741
G+Y + W GSN +MS RPI N + F K F G + +++
Sbjct: 91 GEYPRWDAWSGSNAYHIERLMSFRPI----CSANHKESKMTIFEKENFIGRQWEISDDYP 146
Query: 742 DLTSL-----MPCSFKVLRGCWLLY----YQEDMFVNHCVLEEGLYADLTSCGCPA--SK 790
L ++ S K+ G W+ Y Y+ ++ C G Y G A S+
Sbjct: 147 SLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQ 206
Query: 791 VKSLKPI 797
++S++ I
Sbjct: 207 IQSIRRI 213
Score = 54.7 bits (130), Expect = 4e-07
Identities = 50/172 (29%), Positives = 77/172 (44%), Gaps = 18/172 (10%)
Query: 343 NPRPG-----KMVIYDLHESTYKQ-EVYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHF 396
NP PG K+ IYD K+ E + P+ + SF N +KV G WI YE F
Sbjct: 22 NPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSF 81
Query: 397 RGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI----PEIELFPQSDPA 452
GQ+ +LE GE W N H +R L S + + CS ++ +F + +
Sbjct: 82 CGQQFILERGEYPRWDAWSGSNAYHIER---LMSFRPI---CSANHKESKMTIFEKENFI 135
Query: 453 CCPVYIQRAVPNLEELN--ISKSVSFTVKSGVWLAYPDINFKGQATVLEEDH 502
I P+L+ + ++ S ++SG W+ Y ++G +LE DH
Sbjct: 136 GRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDH 187
Score = 46.6 bits (109), Expect = 1e-04
Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 787 PASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGL 846
P +K+ P I+++ E+ +G+ + + +V + +S+ V+SG
Sbjct: 14 PTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFD-NVRSLKVESGA 72
Query: 847 WIAYEGSNFLGRQILLRPNEIPNWTAFS 874
WI YE ++F G+Q +L E P W A+S
Sbjct: 73 WIGYEHTSFCGQQFILERGEYPRWDAWS 100
Score = 39.3 bits (90), Expect = 0.019
Identities = 38/173 (21%), Positives = 73/173 (42%), Gaps = 11/173 (6%)
Query: 718 PHLLKAFSKPGFQGECIDFTEETSDLTSLM---PCSFKVLRGCWLLYYQEDMFVNHCVLE 774
P + + + FQG+ ++FT +++ S KV G W+ Y +LE
Sbjct: 30 PWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILE 89
Query: 775 EGLY----ADLTSCGCPASKVKSLKPIDYV-FEEPSISLFALEHCEGRELHLEEAVNSVL 829
G Y A S ++ S +PI +E +++F E+ GR+ + + S+
Sbjct: 90 RGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQ 149
Query: 830 NKD-LHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIGS 881
+ S+ ++SG W+ Y+ + G Q +L + + + W+ GS
Sbjct: 150 AMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDH--HGGDYKHWREWGS 200
>gi|16936542 crystallin, beta A2 [Homo sapiens]
Length = 197
Score = 89.4 bits (220), Expect = 2e-17
Identities = 56/132 (42%), Positives = 78/132 (59%), Gaps = 7/132 (5%)
Query: 563 GDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSS----PILSFR-YL 617
G R+ S++V GVWVA+E F+GQQF+LE+GD+ +A SS +LSFR L
Sbjct: 40 GGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVL 99
Query: 618 QANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSK-TRSIHVKSGVWVAYQQKFF 676
AN +S VTLFE D G D+ + + L +G+ SK S+ V SG WVAYQ +
Sbjct: 100 CANHNDSRVTLFEGDNFQGCKFDLVD-DYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGY 158
Query: 677 CGEQYILEKGKY 688
G QY+LE+ ++
Sbjct: 159 RGYQYVLERDRH 170
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/147 (30%), Positives = 75/147 (51%), Gaps = 14/147 (9%)
Query: 624 SSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYIL 683
+S+TL++ + G+ + + + +++ E G + RS+ V++GVWVA++ F G+Q+IL
Sbjct: 12 ASLTLWDEEDFQGRRCRLLS-DCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFIL 70
Query: 684 EKGKYKCFFDWGGS----NNIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEE 739
EKG Y + W GS +N ++S RP+ L N + F FQG D ++
Sbjct: 71 EKGDYPRWSAWSGSSSHNSNQLLSFRPV----LCANHNDSRVTLFEGDNFQGCKFDLVDD 126
Query: 740 TSDLTSLMPC-----SFKVLRGCWLLY 761
L S+ S KV G W+ Y
Sbjct: 127 YPSLPSMGWASKDVGSLKVSSGAWVAY 153
Score = 49.3 bits (116), Expect = 2e-05
Identities = 33/128 (25%), Positives = 64/128 (50%), Gaps = 16/128 (12%)
Query: 475 SFTVKSGVWLAYPDINFKGQATVLEEDH--------GLFEISTAEMKSLHPLQMGGLKVE 526
S V++GVW+A+ +F+GQ +LE+ G ++ ++ S P+
Sbjct: 47 SVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHN-- 104
Query: 527 MPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHF 586
+ +V ++E +F G + + S+P+ + D +GS++V G WVAY+ +
Sbjct: 105 ---DSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKD---VGSLKVSSGAWVAYQYPGY 158
Query: 587 KGQQFLLE 594
+G Q++LE
Sbjct: 159 RGYQYVLE 166
Score = 48.9 bits (115), Expect = 2e-05
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 4/131 (3%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
+KV G W+ +E P F+GQ+ +LE+G+ W N +L + + +
Sbjct: 48 VKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAW--SGSSSHNSNQLLSFRPVLCANHND 105
Query: 441 PEIELFPQSDPACCPVYIQRAVPNLEELN-ISKSV-SFTVKSGVWLAYPDINFKGQATVL 498
+ LF + C + P+L + SK V S V SG W+AY ++G VL
Sbjct: 106 SRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165
Query: 499 EEDHGLFEIST 509
E D E T
Sbjct: 166 ERDRHSGEFCT 176
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/70 (31%), Positives = 40/70 (57%)
Query: 805 SISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRP 864
S++L+ E +GR L +V + +SV V++G+W+A+E +F G+Q +L
Sbjct: 13 SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72
Query: 865 NEIPNWTAFS 874
+ P W+A+S
Sbjct: 73 GDYPRWSAWS 82
Score = 32.7 bits (73), Expect = 1.8
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 14/123 (11%)
Query: 750 SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPAS----KVKSLKPIDYVFEEPS 805
S KV G W+ + D +LE+G Y ++ +S ++ S +P+ S
Sbjct: 47 SVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDS 106
Query: 806 -ISLFALEHCEGRELHLEEAVNSV-----LNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQ 859
++LF ++ +G + L + S+ +KD+ S+ V SG W+AY+ + G Q
Sbjct: 107 RVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVG----SLKVSSGAWVAYQYPGYRGYQ 162
Query: 860 ILL 862
+L
Sbjct: 163 YVL 165
Score = 30.8 bits (68), Expect = 6.8
Identities = 14/41 (34%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 364 YCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLE 404
Y ++P + W+ + +KV G W+ Y+ P +RG + VLE
Sbjct: 127 YPSLP-SMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLE 166
>gi|16936540 crystallin, beta A2 [Homo sapiens]
Length = 197
Score = 89.4 bits (220), Expect = 2e-17
Identities = 56/132 (42%), Positives = 78/132 (59%), Gaps = 7/132 (5%)
Query: 563 GDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSS----PILSFR-YL 617
G R+ S++V GVWVA+E F+GQQF+LE+GD+ +A SS +LSFR L
Sbjct: 40 GGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVL 99
Query: 618 QANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSK-TRSIHVKSGVWVAYQQKFF 676
AN +S VTLFE D G D+ + + L +G+ SK S+ V SG WVAYQ +
Sbjct: 100 CANHNDSRVTLFEGDNFQGCKFDLVD-DYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGY 158
Query: 677 CGEQYILEKGKY 688
G QY+LE+ ++
Sbjct: 159 RGYQYVLERDRH 170
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/147 (30%), Positives = 75/147 (51%), Gaps = 14/147 (9%)
Query: 624 SSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYIL 683
+S+TL++ + G+ + + + +++ E G + RS+ V++GVWVA++ F G+Q+IL
Sbjct: 12 ASLTLWDEEDFQGRRCRLLS-DCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFIL 70
Query: 684 EKGKYKCFFDWGGS----NNIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEE 739
EKG Y + W GS +N ++S RP+ L N + F FQG D ++
Sbjct: 71 EKGDYPRWSAWSGSSSHNSNQLLSFRPV----LCANHNDSRVTLFEGDNFQGCKFDLVDD 126
Query: 740 TSDLTSLMPC-----SFKVLRGCWLLY 761
L S+ S KV G W+ Y
Sbjct: 127 YPSLPSMGWASKDVGSLKVSSGAWVAY 153
Score = 49.3 bits (116), Expect = 2e-05
Identities = 33/128 (25%), Positives = 64/128 (50%), Gaps = 16/128 (12%)
Query: 475 SFTVKSGVWLAYPDINFKGQATVLEEDH--------GLFEISTAEMKSLHPLQMGGLKVE 526
S V++GVW+A+ +F+GQ +LE+ G ++ ++ S P+
Sbjct: 47 SVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHN-- 104
Query: 527 MPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHF 586
+ +V ++E +F G + + S+P+ + D +GS++V G WVAY+ +
Sbjct: 105 ---DSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKD---VGSLKVSSGAWVAYQYPGY 158
Query: 587 KGQQFLLE 594
+G Q++LE
Sbjct: 159 RGYQYVLE 166
Score = 48.9 bits (115), Expect = 2e-05
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 4/131 (3%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
+KV G W+ +E P F+GQ+ +LE+G+ W N +L + + +
Sbjct: 48 VKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAW--SGSSSHNSNQLLSFRPVLCANHND 105
Query: 441 PEIELFPQSDPACCPVYIQRAVPNLEELN-ISKSV-SFTVKSGVWLAYPDINFKGQATVL 498
+ LF + C + P+L + SK V S V SG W+AY ++G VL
Sbjct: 106 SRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165
Query: 499 EEDHGLFEIST 509
E D E T
Sbjct: 166 ERDRHSGEFCT 176
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/70 (31%), Positives = 40/70 (57%)
Query: 805 SISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRP 864
S++L+ E +GR L +V + +SV V++G+W+A+E +F G+Q +L
Sbjct: 13 SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72
Query: 865 NEIPNWTAFS 874
+ P W+A+S
Sbjct: 73 GDYPRWSAWS 82
Score = 32.7 bits (73), Expect = 1.8
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 14/123 (11%)
Query: 750 SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPAS----KVKSLKPIDYVFEEPS 805
S KV G W+ + D +LE+G Y ++ +S ++ S +P+ S
Sbjct: 47 SVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDS 106
Query: 806 -ISLFALEHCEGRELHLEEAVNSV-----LNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQ 859
++LF ++ +G + L + S+ +KD+ S+ V SG W+AY+ + G Q
Sbjct: 107 RVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVG----SLKVSSGAWVAYQYPGYRGYQ 162
Query: 860 ILL 862
+L
Sbjct: 163 YVL 165
Score = 30.8 bits (68), Expect = 6.8
Identities = 14/41 (34%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 364 YCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLE 404
Y ++P + W+ + +KV G W+ Y+ P +RG + VLE
Sbjct: 127 YPSLP-SMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLE 166
>gi|7019357 crystallin, beta A2 [Homo sapiens]
Length = 197
Score = 89.4 bits (220), Expect = 2e-17
Identities = 56/132 (42%), Positives = 78/132 (59%), Gaps = 7/132 (5%)
Query: 563 GDFHRIGSIRVIGGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSS----PILSFR-YL 617
G R+ S++V GVWVA+E F+GQQF+LE+GD+ +A SS +LSFR L
Sbjct: 40 GGLPRVRSVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVL 99
Query: 618 QANFIESSVTLFESDLESGKFIDITNQEISDLEEIGFGSK-TRSIHVKSGVWVAYQQKFF 676
AN +S VTLFE D G D+ + + L +G+ SK S+ V SG WVAYQ +
Sbjct: 100 CANHNDSRVTLFEGDNFQGCKFDLVD-DYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGY 158
Query: 677 CGEQYILEKGKY 688
G QY+LE+ ++
Sbjct: 159 RGYQYVLERDRH 170
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/147 (30%), Positives = 75/147 (51%), Gaps = 14/147 (9%)
Query: 624 SSVTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYIL 683
+S+TL++ + G+ + + + +++ E G + RS+ V++GVWVA++ F G+Q+IL
Sbjct: 12 ASLTLWDEEDFQGRRCRLLS-DCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFIL 70
Query: 684 EKGKYKCFFDWGGS----NNIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEE 739
EKG Y + W GS +N ++S RP+ L N + F FQG D ++
Sbjct: 71 EKGDYPRWSAWSGSSSHNSNQLLSFRPV----LCANHNDSRVTLFEGDNFQGCKFDLVDD 126
Query: 740 TSDLTSLMPC-----SFKVLRGCWLLY 761
L S+ S KV G W+ Y
Sbjct: 127 YPSLPSMGWASKDVGSLKVSSGAWVAY 153
Score = 49.3 bits (116), Expect = 2e-05
Identities = 33/128 (25%), Positives = 64/128 (50%), Gaps = 16/128 (12%)
Query: 475 SFTVKSGVWLAYPDINFKGQATVLEEDH--------GLFEISTAEMKSLHPLQMGGLKVE 526
S V++GVW+A+ +F+GQ +LE+ G ++ ++ S P+
Sbjct: 47 SVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHN-- 104
Query: 527 MPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHF 586
+ +V ++E +F G + + S+P+ + D +GS++V G WVAY+ +
Sbjct: 105 ---DSRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKD---VGSLKVSSGAWVAYQYPGY 158
Query: 587 KGQQFLLE 594
+G Q++LE
Sbjct: 159 RGYQYVLE 166
Score = 48.9 bits (115), Expect = 2e-05
Identities = 37/131 (28%), Positives = 57/131 (43%), Gaps = 4/131 (3%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
+KV G W+ +E P F+GQ+ +LE+G+ W N +L + + +
Sbjct: 48 VKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAW--SGSSSHNSNQLLSFRPVLCANHND 105
Query: 441 PEIELFPQSDPACCPVYIQRAVPNLEELN-ISKSV-SFTVKSGVWLAYPDINFKGQATVL 498
+ LF + C + P+L + SK V S V SG W+AY ++G VL
Sbjct: 106 SRVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVL 165
Query: 499 EEDHGLFEIST 509
E D E T
Sbjct: 166 ERDRHSGEFCT 176
Score = 43.5 bits (101), Expect = 0.001
Identities = 22/70 (31%), Positives = 40/70 (57%)
Query: 805 SISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRP 864
S++L+ E +GR L +V + +SV V++G+W+A+E +F G+Q +L
Sbjct: 13 SLTLWDEEDFQGRRCRLLSDCANVCERGGLPRVRSVKVENGVWVAFEYPDFQGQQFILEK 72
Query: 865 NEIPNWTAFS 874
+ P W+A+S
Sbjct: 73 GDYPRWSAWS 82
Score = 32.7 bits (73), Expect = 1.8
Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 14/123 (11%)
Query: 750 SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPAS----KVKSLKPIDYVFEEPS 805
S KV G W+ + D +LE+G Y ++ +S ++ S +P+ S
Sbjct: 47 SVKVENGVWVAFEYPDFQGQQFILEKGDYPRWSAWSGSSSHNSNQLLSFRPVLCANHNDS 106
Query: 806 -ISLFALEHCEGRELHLEEAVNSV-----LNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQ 859
++LF ++ +G + L + S+ +KD+ S+ V SG W+AY+ + G Q
Sbjct: 107 RVTLFEGDNFQGCKFDLVDDYPSLPSMGWASKDVG----SLKVSSGAWVAYQYPGYRGYQ 162
Query: 860 ILL 862
+L
Sbjct: 163 YVL 165
Score = 30.8 bits (68), Expect = 6.8
Identities = 14/41 (34%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 364 YCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLE 404
Y ++P + W+ + +KV G W+ Y+ P +RG + VLE
Sbjct: 127 YPSLP-SMGWASKDVGSLKVSSGAWVAYQYPGYRGYQYVLE 166
>gi|4503059 crystallin, beta A4 [Homo sapiens]
Length = 196
Score = 88.6 bits (218), Expect = 3e-17
Identities = 61/189 (32%), Positives = 101/189 (53%), Gaps = 18/189 (9%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K++++++ F G+ EF+ SV F + S++V+ G WV +E F+GQQ+
Sbjct: 13 KMVVWDEDGFQGRRHEFTAECPSVLEL-----GFETVRSLKVLSGAWVGFEHAGFQGQQY 67
Query: 592 LLEEGDFEDSNACGALSS----PILSFRYLQ-ANFIESSVTLFESDLESGKFIDITNQEI 646
+LE G++ +A G ++ + SFR AN +S +T+FE + GK ++++ +
Sbjct: 68 ILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSD-DY 126
Query: 647 SDLEEIGF-GSKTRSIHVKSGVWVAYQQKFFCGEQYILE----KGKYKCFFDWGGSNNI- 700
L+ +G+ G++ S HV SG WV Q + G QY+LE G YK F +WG
Sbjct: 127 PSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDHHSGDYKHFREWGSHAPTF 186
Query: 701 -IMSIRPIQ 708
+ SIR IQ
Sbjct: 187 QVQSIRRIQ 195
Score = 55.5 bits (132), Expect = 3e-07
Identities = 47/165 (28%), Positives = 73/165 (44%), Gaps = 14/165 (8%)
Query: 645 EISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSI 704
E + E+GF + RS+ V SG WV ++ F G+QYILE+G+Y + WGG N +
Sbjct: 32 ECPSVLELGFET-VRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGG-NTAYPAE 89
Query: 705 RPIQLEPLG-INEPPHLLKAFSKPGFQGECIDFTEETSDLTSL-----MPCSFKVLRGCW 758
R P N L F + F G+ + +++ L ++ SF V G W
Sbjct: 90 RLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAW 149
Query: 759 LLY----YQEDMFVNHCVLEEGLYADLTSCG--CPASKVKSLKPI 797
+ Y+ +V C G Y G P +V+S++ I
Sbjct: 150 VCSQFPGYRGFQYVLECDHHSGDYKHFREWGSHAPTFQVQSIRRI 194
Score = 47.4 bits (111), Expect = 7e-05
Identities = 37/156 (23%), Positives = 64/156 (41%), Gaps = 20/156 (12%)
Query: 463 PNLEELNISKSVSFTVKSGVWLAYPDINFKGQATVLEEDH--------GLFEISTAEMKS 514
P++ EL S V SG W+ + F+GQ +LE G + S
Sbjct: 34 PSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTS 93
Query: 515 LHPLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVI 574
P + + ++ I+E+ +F G+ E S D P+ + + +GS V
Sbjct: 94 FRPAACANHR-----DSRLTIFEQENFLGKKGELS---DDYPSLQAMGWEGNEVGSFHVH 145
Query: 575 GGVWVAYEKEHFKGQQFLLE----EGDFEDSNACGA 606
G WV + ++G Q++LE GD++ G+
Sbjct: 146 SGAWVCSQFPGYRGFQYVLECDHHSGDYKHFREWGS 181
Score = 41.2 bits (95), Expect = 0.005
Identities = 43/171 (25%), Positives = 70/171 (40%), Gaps = 11/171 (6%)
Query: 339 TLRCNPRPG--KMVIYDLHESTY---KQEVYCNIPDATSWSFPNGVLIKVVRGCWILYEK 393
TL+C G KMV++D E + + E P F +KV+ G W+ +E
Sbjct: 2 TLQCTKSAGPWKMVVWD--EDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEH 59
Query: 394 PHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSIPEIELFPQSDPAC 453
F+GQ+ +LE GE W N +P + + + +F Q +
Sbjct: 60 AGFQGQQYILERGEYPSWDAW-GGNTAYPAER-LTSFRPAACANHRDSRLTIFEQENFLG 117
Query: 454 CPVYIQRAVPNLEELNI--SKSVSFTVKSGVWLAYPDINFKGQATVLEEDH 502
+ P+L+ + ++ SF V SG W+ ++G VLE DH
Sbjct: 118 KKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVCSQFPGYRGFQYVLECDH 168
Score = 37.4 bits (85), Expect = 0.073
Identities = 22/60 (36%), Positives = 33/60 (55%), Gaps = 3/60 (5%)
Query: 815 EGRELHLEEAVNSVLNKDLHFYT-QSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAF 873
+GR SVL +L F T +S+ V SG W+ +E + F G+Q +L E P+W A+
Sbjct: 23 QGRRHEFTAECPSVL--ELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAW 80
>gi|148491074 crystallin, gamma B [Homo sapiens]
Length = 175
Score = 84.7 bits (208), Expect = 4e-16
Identities = 48/176 (27%), Positives = 87/176 (49%), Gaps = 7/176 (3%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ YE F G++ E + ++ + F R SIRV G W+ YE+ +++G Q+
Sbjct: 3 KITFYEDRAFQGRSYECTTDCPNLQPY------FSRCNSIRVESGCWMIYERPNYQGHQY 56
Query: 592 LLEEGDFEDSNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEE 651
L G++ D LS I S + + + +++ D G+ ++T+ IS +
Sbjct: 57 FLRRGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDR 116
Query: 652 IGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPI 707
++ S++V G W+ Y+ + G QY+L G+Y+ F DWG N + S+R +
Sbjct: 117 FHL-TEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRV 171
Score = 62.8 bits (151), Expect = 2e-09
Identities = 46/180 (25%), Positives = 80/180 (44%), Gaps = 20/180 (11%)
Query: 626 VTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEK 685
+T +E G+ + T + +L+ + S+ SI V+SG W+ Y++ + G QY L +
Sbjct: 4 ITFYEDRAFQGRSYECTT-DCPNLQP--YFSRCNSIRVESGCWMIYERPNYQGHQYFLRR 60
Query: 686 GKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHL----LKAFSKPGFQGECIDFTEETS 741
G+Y + W G ++ I S I PPH +K + + +G+ + T++
Sbjct: 61 GEYPDYQQWMGLSDSIRSCCLI---------PPHSGAYRMKIYDRDELRGQMSELTDDCI 111
Query: 742 DLTSLMPC----SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPI 797
+ S VL G W+LY + +L G Y G P +KV SL+ +
Sbjct: 112 SVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRV 171
Score = 51.6 bits (122), Expect = 4e-06
Identities = 43/161 (26%), Positives = 75/161 (46%), Gaps = 23/161 (14%)
Query: 463 PNLEELNISKSVSFTVKSGVWLAYPDINFKGQATVLEE----DHGLFEISTAEMKS--LH 516
PNL+ S+ S V+SG W+ Y N++G L D+ + + ++S L
Sbjct: 24 PNLQPY-FSRCNSIRVESGCWMIYERPNYQGHQYFLRRGEYPDYQQWMGLSDSIRSCCLI 82
Query: 517 PLQMGGLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFH--RIGSIRVI 574
P G +++ IY++ GQ E ++ SV + FH I S+ V+
Sbjct: 83 PPHSGAYRMK--------IYDRDELRGQMSELTDDCISVQD------RFHLTEIHSLNVL 128
Query: 575 GGVWVAYEKEHFKGQQFLLEEGDFEDSNACGALSSPILSFR 615
G W+ YE +++G+Q+LL G++ GA ++ + S R
Sbjct: 129 EGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLR 169
Score = 49.3 bits (116), Expect = 2e-05
Identities = 46/164 (28%), Positives = 69/164 (42%), Gaps = 15/164 (9%)
Query: 729 FQGECIDFTEETSDLTSLMPC-----SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTS 783
FQG E T+D +L P S +V GCW++Y + + + L G Y D
Sbjct: 12 FQGRSY---ECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRRGEYPDYQQ 68
Query: 784 CGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVK 843
+ ++S I + ++ + G+ L + SV ++ S+ V
Sbjct: 69 WMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLTEIHSLNVL 128
Query: 844 SGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRW----KTIGSLR 883
G WI YE N+ GRQ LLRP E + F W +GSLR
Sbjct: 129 EGSWILYEMPNYRGRQYLLRPGE---YRRFLDWGAPNAKVGSLR 169
Score = 41.2 bits (95), Expect = 0.005
Identities = 21/55 (38%), Positives = 32/55 (58%), Gaps = 7/55 (12%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVL 435
+ V+ G WILYE P++RG++ +L GE DW N + +GSL+RV+
Sbjct: 125 LNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAK-------VGSLRRVM 172
Score = 38.5 bits (88), Expect = 0.033
Identities = 28/130 (21%), Positives = 51/130 (39%), Gaps = 30/130 (23%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
I+V GCW++YE+P+++G + L GE + W +G + C I
Sbjct: 36 IRVESGCWMIYERPNYQGHQYFLRRGEYPDYQQW-------------MGLSDSIRSCCLI 82
Query: 441 PEIELFPQSDPACCPVY------------IQRAVPNLEELNISKSVSFTVKSGVWLAYPD 488
P P S +Y + + ++++ S V G W+ Y
Sbjct: 83 P-----PHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLTEIHSLNVLEGSWILYEM 137
Query: 489 INFKGQATVL 498
N++G+ +L
Sbjct: 138 PNYRGRQYLL 147
>gi|13377002 crystallin, gamma D [Homo sapiens]
Length = 174
Score = 82.4 bits (202), Expect = 2e-15
Identities = 51/176 (28%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ +YE F G+ E S ++ +L R S RV G W+ YE+ ++ G Q+
Sbjct: 3 KITLYEDRGFQGRHYECSSDHPNLQPYLS------RCNSARVDSGCWMLYEQPNYSGLQY 56
Query: 592 LLEEGDFEDSNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEE 651
L GD+ D LS + S R + + + L+E + G+ I+ T ++ S L++
Sbjct: 57 FLRRGDYADHQQWMGLSDSVRSCRLIPHSG-SHRIRLYEREDYRGQMIEFT-EDCSCLQD 114
Query: 652 IGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPI 707
++ S++V G WV Y+ + G QY+L G Y+ + DWG +N + S+R +
Sbjct: 115 RFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRV 170
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/146 (28%), Positives = 66/146 (45%), Gaps = 10/146 (6%)
Query: 656 SKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGIN 715
S+ S V SG W+ Y+Q + G QY L +G Y W G ++ + S R I +
Sbjct: 31 SRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIP------H 84
Query: 716 EPPHLLKAFSKPGFQGECIDFTEETSDLTSLMPC----SFKVLRGCWLLYYQEDMFVNHC 771
H ++ + + ++G+ I+FTE+ S L S VL G W+LY +
Sbjct: 85 SGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQY 144
Query: 772 VLEEGLYADLTSCGCPASKVKSLKPI 797
+L G Y G ++V SL+ +
Sbjct: 145 LLMPGDYRRYQDWGATNARVGSLRRV 170
Score = 53.1 bits (126), Expect = 1e-06
Identities = 48/161 (29%), Positives = 73/161 (45%), Gaps = 8/161 (4%)
Query: 728 GFQGECIDFTEETSDLTS-LMPC-SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCG 785
GFQG + + + +L L C S +V GCW+LY Q + L G YAD
Sbjct: 11 GFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWM 70
Query: 786 CPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSG 845
+ V+S + I + I L+ E G+ + E + + ++ S+ V G
Sbjct: 71 GLSDSVRSCRLIPHSGSH-RIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEG 129
Query: 846 LWIAYEGSNFLGRQILLRPNE---IPNWTAFSRWKTIGSLR 883
W+ YE SN+ GRQ LL P + +W A + +GSLR
Sbjct: 130 SWVLYELSNYRGRQYLLMPGDYRRYQDWGATN--ARVGSLR 168
Score = 38.1 bits (87), Expect = 0.043
Identities = 19/55 (34%), Positives = 32/55 (58%), Gaps = 7/55 (12%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVL 435
+ V+ G W+LYE ++RG++ +L G+ +DW N R +GSL+RV+
Sbjct: 124 LNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNAR-------VGSLRRVI 171
Score = 35.4 bits (80), Expect = 0.28
Identities = 26/120 (21%), Positives = 53/120 (44%), Gaps = 13/120 (10%)
Query: 382 KVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLK--RVLKDCS 439
+V GCW+LYE+P++ G + L G+ ++ W+ + S++ R++
Sbjct: 37 RVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWM----------GLSDSVRSCRLIPHSG 86
Query: 440 IPEIELFPQSDPACCPVYIQRAVPNLEE-LNISKSVSFTVKSGVWLAYPDINFKGQATVL 498
I L+ + D + L++ ++ S V G W+ Y N++G+ +L
Sbjct: 87 SHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLL 146
>gi|148491057 crystallin, gamma A [Homo sapiens]
Length = 174
Score = 82.0 bits (201), Expect = 3e-15
Identities = 52/176 (29%), Positives = 85/176 (48%), Gaps = 8/176 (4%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ YE F G+ I PN F R SIRV G W+ YE+ +++G Q+
Sbjct: 3 KITFYEDRDFQGRCYNC---ISDCPNLRVY---FSRCNSIRVDSGCWMLYERPNYQGHQY 56
Query: 592 LLEEGDFEDSNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEE 651
L G + D LS + S R + + + L+E D G ++T+ + + + E
Sbjct: 57 FLRRGKYPDYQHWMGLSDSVQSCRIIP-HTSSHKLRLYERDDYRGLMSELTD-DCACVPE 114
Query: 652 IGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPI 707
+ + S+HV G WV Y+ + G QY+L G Y+ + DWGG++ + S+R +
Sbjct: 115 LFRLPEIYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLRRV 170
Score = 65.1 bits (157), Expect = 3e-10
Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 10/146 (6%)
Query: 656 SKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGIN 715
S+ SI V SG W+ Y++ + G QY L +GKY + W G ++ + S R I +
Sbjct: 31 SRCNSIRVDSGCWMLYERPNYQGHQYFLRRGKYPDYQHWMGLSDSVQSCRIIP------H 84
Query: 716 EPPHLLKAFSKPGFQGECIDFTEETSDLTSLMPC----SFKVLRGCWLLYYQEDMFVNHC 771
H L+ + + ++G + T++ + + L S VL GCW+LY +
Sbjct: 85 TSSHKLRLYERDDYRGLMSELTDDCACVPELFRLPEIYSLHVLEGCWVLYEMPNYRGRQY 144
Query: 772 VLEEGLYADLTSCGCPASKVKSLKPI 797
+L G Y G +KV SL+ +
Sbjct: 145 LLRPGDYRRYHDWGGADAKVGSLRRV 170
Score = 47.0 bits (110), Expect = 9e-05
Identities = 43/161 (26%), Positives = 66/161 (40%), Gaps = 10/161 (6%)
Query: 729 FQGECIDFTEETSDLTSLMP-C-SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGC 786
FQG C + + +L C S +V GCW+LY + + + L G Y D
Sbjct: 12 FQGRCYNCISDCPNLRVYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRRGKYPDYQHWMG 71
Query: 787 PASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGL 846
+ V+S + I + + L+ + G L + V S+ V G
Sbjct: 72 LSDSVQSCRIIPHTSSH-KLRLYERDDYRGLMSELTDDCACVPELFRLPEIYSLHVLEGC 130
Query: 847 WIAYEGSNFLGRQILLRPNEIPNWTAFSRW----KTIGSLR 883
W+ YE N+ GRQ LLRP + + + W +GSLR
Sbjct: 131 WVLYEMPNYRGRQYLLRPGD---YRRYHDWGGADAKVGSLR 168
Score = 40.4 bits (93), Expect = 0.009
Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 7/54 (12%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRV 434
+ V+ GCW+LYE P++RG++ +L G+ DW + + +GSL+RV
Sbjct: 124 LHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAK-------VGSLRRV 170
Score = 37.4 bits (85), Expect = 0.073
Identities = 29/130 (22%), Positives = 51/130 (39%), Gaps = 31/130 (23%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDW------------ILQNRRHPQRNFIL 428
I+V GCW+LYE+P+++G + L G+ + W I H R +
Sbjct: 36 IRVDSGCWMLYERPNYQGHQYFLRRGKYPDYQHWMGLSDSVQSCRIIPHTSSHKLRLYER 95
Query: 429 GSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSVSFTVKSGVWLAYPD 488
+ ++ + + D AC P E + + S V G W+ Y
Sbjct: 96 DDYRGLMSELT---------DDCACVP----------ELFRLPEIYSLHVLEGCWVLYEM 136
Query: 489 INFKGQATVL 498
N++G+ +L
Sbjct: 137 PNYRGRQYLL 146
>gi|10518338 crystallin, gamma C [Homo sapiens]
Length = 174
Score = 81.3 bits (199), Expect = 4e-15
Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 8/176 (4%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ YE F G++ E + ++ + F R SIRV G W+ YE+ +++GQQ+
Sbjct: 3 KITFYEDRAFQGRSYETTTDCPNLQPY------FSRCNSIRVESGCWMLYERPNYQGQQY 56
Query: 592 LLEEGDFEDSNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISDLEE 651
LL G++ D LS I S L + + L+E + G +++ +++ +++
Sbjct: 57 LLRRGEYPDYQQWMGLSDSIRSC-CLIPQTVSHRLRLYEREDHKGLMMEL-SEDCPSIQD 114
Query: 652 IGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPI 707
S+ RS+HV G WV Y+ + G QY+L +Y+ DWG + S+R +
Sbjct: 115 RFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRV 170
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/176 (25%), Positives = 82/176 (46%), Gaps = 13/176 (7%)
Query: 626 VTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEK 685
+T +E G+ + T + +L+ + S+ SI V+SG W+ Y++ + G+QY+L +
Sbjct: 4 ITFYEDRAFQGRSYETTT-DCPNLQP--YFSRCNSIRVESGCWMLYERPNYQGQQYLLRR 60
Query: 686 GKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEETSDLTS 745
G+Y + W G ++ SIR L P ++ H L+ + + +G ++ +E+ +
Sbjct: 61 GEYPDYQQWMGLSD---SIRSCCLIPQTVS---HRLRLYEREDHKGLMMELSEDCPSIQD 114
Query: 746 LMPCS----FKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTSCGCPASKVKSLKPI 797
S VL GCW+LY + +L Y G +K SL+ +
Sbjct: 115 RFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRV 170
Score = 54.7 bits (130), Expect = 4e-07
Identities = 48/163 (29%), Positives = 70/163 (42%), Gaps = 14/163 (8%)
Query: 729 FQGECIDFTEETSDLTSLMPC-----SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADLTS 783
FQG E T+D +L P S +V GCW+LY + + +L G Y D
Sbjct: 12 FQGRSY---ETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQ 68
Query: 784 CGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVK 843
+ ++S I + L+ E +G + L E S+ ++ +S+ V
Sbjct: 69 WMGLSDSIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQDRFHLSEIRSLHVL 127
Query: 844 SGLWIAYEGSNFLGRQILLRPNE---IPNWTAFSRWKTIGSLR 883
G W+ YE N+ GRQ LLRP E +W A GSLR
Sbjct: 128 EGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMD--AKAGSLR 168
Score = 51.2 bits (121), Expect = 5e-06
Identities = 38/153 (24%), Positives = 67/153 (43%), Gaps = 8/153 (5%)
Query: 463 PNLEELNISKSVSFTVKSGVWLAYPDINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGG 522
PNL+ S+ S V+SG W+ Y N++GQ +L + L
Sbjct: 24 PNLQPY-FSRCNSIRVESGCWMLYERPNYQGQQYLLRRGE---YPDYQQWMGLSDSIRSC 79
Query: 523 LKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYE 582
+ ++ ++ +YE+ G E SE S+ ++ I S+ V+ G WV YE
Sbjct: 80 CLIPQTVSHRLRLYEREDHKGLMMELSEDCPSI----QDRFHLSEIRSLHVLEGCWVLYE 135
Query: 583 KEHFKGQQFLLEEGDFEDSNACGALSSPILSFR 615
+++G+Q+LL ++ GA+ + S R
Sbjct: 136 LPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLR 168
Score = 50.8 bits (120), Expect = 6e-06
Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 19/124 (15%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVLKDCSI 440
I+V GCW+LYE+P+++GQ+ +L GE + W +G + C I
Sbjct: 36 IRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQW-------------MGLSDSIRSCCLI 82
Query: 441 PE-----IELFPQSDPACCPVYIQRAVPNLEE-LNISKSVSFTVKSGVWLAYPDINFKGQ 494
P+ + L+ + D + + P++++ ++S+ S V G W+ Y N++G+
Sbjct: 83 PQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGR 142
Query: 495 ATVL 498
+L
Sbjct: 143 QYLL 146
Score = 39.3 bits (90), Expect = 0.019
Identities = 19/55 (34%), Positives = 32/55 (58%), Gaps = 7/55 (12%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRVL 435
+ V+ GCW+LYE P++RG++ +L E +DW + + GSL+RV+
Sbjct: 124 LHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAK-------AGSLRRVV 171
>gi|8922120 crystallin, gamma S [Homo sapiens]
Length = 178
Score = 74.3 bits (181), Expect = 5e-13
Identities = 47/177 (26%), Positives = 83/177 (46%), Gaps = 8/177 (4%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ YE +F G+ + +L R SI+V GG W YE+ +F G +
Sbjct: 7 KITFYEDKNFQGRRYDCDCDCADFHTYLS------RCNSIKVEGGTWAVYERPNFAGYMY 60
Query: 592 LLEEGDFEDSNACGALSSPILSFRYLQA-NFIESSVTLFESDLESGKFIDITNQEISDLE 650
+L +G++ + L+ + S R + + + + +FE SG+ + T S +E
Sbjct: 61 ILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIME 120
Query: 651 EIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPI 707
+ + S V GVW+ Y+ + G QY+L+K +Y+ DWG ++ + S R I
Sbjct: 121 QFHM-REIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRI 176
Score = 60.8 bits (146), Expect = 6e-09
Identities = 40/146 (27%), Positives = 65/146 (44%), Gaps = 8/146 (5%)
Query: 656 SKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRPIQLEPLGIN 715
S+ SI V+ G W Y++ F G YIL +G+Y + W G N+ + S R + L G
Sbjct: 35 SRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGG-- 92
Query: 716 EPPHLLKAFSKPGFQGECIDFTEETSDLTSLMPC----SFKVLRGCWLLYYQEDMFVNHC 771
+ ++ F K F G+ + TE+ + S KVL G W+ Y +
Sbjct: 93 --QYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQY 150
Query: 772 VLEEGLYADLTSCGCPASKVKSLKPI 797
+L++ Y G + V+S + I
Sbjct: 151 LLDKKEYRKPIDWGAASPAVQSFRRI 176
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 25/156 (16%)
Query: 470 ISKSVSFTVKSGVWLAYPDINFKGQATVLEEDH--------GLFEISTAEMKSLHPLQMG 521
+S+ S V+ G W Y NF G +L + GL + + +++H L G
Sbjct: 34 LSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLND-RLSSCRAVH-LPSG 91
Query: 522 GLKVEMPMNLKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFH--RIGSIRVIGGVWV 579
G K+ I+EK F GQ E +E S+ FH I S +V+ GVW+
Sbjct: 92 G-------QYKIQIFEKGDFSGQMYETTEDCPSIME------QFHMREIHSCKVLEGVWI 138
Query: 580 AYEKEHFKGQQFLLEEGDFEDSNACGALSSPILSFR 615
YE +++G+Q+LL++ ++ GA S + SFR
Sbjct: 139 FYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFR 174
Score = 44.7 bits (104), Expect = 5e-04
Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 9/122 (7%)
Query: 381 IKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWILQNRRHPQRNFILGSLKRV-LKDCS 439
IKV G W +YE+P+F G +L +GE + W+ N R L S + V L
Sbjct: 40 IKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDR-------LSSCRAVHLPSGG 92
Query: 440 IPEIELFPQSDPACCPVYIQRAVPN-LEELNISKSVSFTVKSGVWLAYPDINFKGQATVL 498
+I++F + D + P+ +E+ ++ + S V GVW+ Y N++G+ +L
Sbjct: 93 QYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLL 152
Query: 499 EE 500
++
Sbjct: 153 DK 154
Score = 37.0 bits (84), Expect = 0.095
Identities = 37/146 (25%), Positives = 58/146 (39%), Gaps = 3/146 (2%)
Query: 724 FSKPGFQGECIDFTEETSDL-TSLMPC-SFKVLRGCWLLYYQEDMFVNHCVLEEGLYADL 781
+ FQG D + +D T L C S KV G W +Y + + +L +G Y +
Sbjct: 11 YEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEY 70
Query: 782 TSCGCPASKVKSLKPIDYVFE-EPSISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSV 840
++ S + + + I +F G+ E S++ + S
Sbjct: 71 QRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSC 130
Query: 841 WVKSGLWIAYEGSNFLGRQILLRPNE 866
V G+WI YE N+ GRQ LL E
Sbjct: 131 KVLEGVWIFYELPNYRGRQYLLDKKE 156
Score = 34.7 bits (78), Expect = 0.47
Identities = 14/33 (42%), Positives = 22/33 (66%)
Query: 382 KVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDW 414
KV+ G WI YE P++RG++ +L++ E DW
Sbjct: 131 KVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDW 163
Score = 31.6 bits (70), Expect = 4.0
Identities = 17/48 (35%), Positives = 21/48 (43%), Gaps = 6/48 (12%)
Query: 832 DLHFYTQ---SVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRW 876
D H Y S+ V+ G W YE NF G +L E P + RW
Sbjct: 29 DFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPE---YQRW 73
>gi|21389517 gammaN-crystallin [Homo sapiens]
Length = 182
Score = 72.4 bits (176), Expect = 2e-12
Identities = 38/120 (31%), Positives = 67/120 (55%), Gaps = 6/120 (5%)
Query: 626 VTLFESDLESGKFIDITNQEISDLEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEK 685
+TL+E +G+ +++ + + ++ GF ++ SIHV+SG WV + F G+Q+ILE
Sbjct: 8 ITLYEGKHFTGQKLEVFG-DCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEH 66
Query: 686 GKYKCFFDWGGSNNIIMSIRPIQLEPLGINEPPHLLKAFSKPGFQGECIDFTEETSDLTS 745
G Y FF W ++ + S RP+ G++ L+ F F G+C++F E++ L S
Sbjct: 67 GDYPDFFRWNSHSDHMGSCRPV-----GMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQS 121
Score = 55.8 bits (133), Expect = 2e-07
Identities = 27/69 (39%), Positives = 38/69 (55%), Gaps = 4/69 (5%)
Query: 532 KVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQF 591
K+ +YE HF GQ E D+ ++ G +R+ SI V G WV + F+GQQF
Sbjct: 7 KITLYEGKHFTGQKLEVFGDCDN----FQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQF 62
Query: 592 LLEEGDFED 600
+LE GD+ D
Sbjct: 63 ILEHGDYPD 71
Score = 40.8 bits (94), Expect = 0.007
Identities = 23/94 (24%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 806 ISLFALEHCEGRELHLEEAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPN 865
I+L+ +H G++L + ++ ++ S+ V+SG W+ + +F G+Q +L
Sbjct: 8 ITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFILEHG 67
Query: 866 EIPNWTAFSRWKT----IGSLRPMKQPAVYIRIK 895
+ P+ F RW + +GS RP+ + R++
Sbjct: 68 DYPD---FFRWNSHSDHMGSCRPVGMHGEHFRLE 98
Score = 40.0 bits (92), Expect = 0.011
Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 345 RPGKMVIYD-LHESTYKQEVYCNIPDATSWSFPNGV-LIKVVRGCWILYEKPHFRGQKCV 402
R GK+ +Y+ H + K EV+ + + F N V I V G W+ + P FRGQ+ +
Sbjct: 4 RSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQQFI 63
Query: 403 LEEGE 407
LE G+
Sbjct: 64 LEHGD 68
Score = 36.2 bits (82), Expect = 0.16
Identities = 37/140 (26%), Positives = 58/140 (41%), Gaps = 14/140 (10%)
Query: 475 SFTVKSGVWLAYPDINFKGQATVLEE----DHGLFEISTAEMKSLHPLQMGGLKVEMPMN 530
S V+SG W+ + +F+GQ +LE D + + M S P+ M G +
Sbjct: 41 SIHVESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCRPVGMHG------EH 94
Query: 531 LKVIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQ 590
++ I+E +F GQ EF E DS FL++ G + + G A+ F +
Sbjct: 95 FRLEIFEGCNFTGQCLEFLE--DS--PFLQSRGWVKNCVNTIKVYGDGAAWSPRSFGAED 150
Query: 591 FLLEEGDFEDSNACGALSSP 610
F L D A + P
Sbjct: 151 FQLSSSLQSDQGPEEATTKP 170
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 41.2 bits (95), Expect = 0.005
Identities = 53/221 (23%), Positives = 94/221 (42%), Gaps = 22/221 (9%)
Query: 20 TAIYDKRRETDYSDKGYNLAFVSQDEQE--------NSSFTILYEEPLQEEDKYASAEAR 71
T ++ + E D G +L +D+Q+ S T + + E +KY +
Sbjct: 500 TIVHRLKDEETNEDSGRDLK-PHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
Query: 72 QTQSVLFHDTSADSMPVLA-CERSESRTDLVHH---FEKGTKLGETFDSDSSEM---FLS 124
Q S + S S+PV A + SE+ +V+H FE+ +L + +EM +
Sbjct: 559 QKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIE 618
Query: 125 VEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSL----LQ 180
+ K+ +ALS +DD+ + D LS EV+ + + S ++ S +SL Q
Sbjct: 619 TSINQPKV--VALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQ 676
Query: 181 SVSERLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGE 221
S + D + +E+E ++L GD+ S E
Sbjct: 677 DTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTE 717
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 41.2 bits (95), Expect = 0.005
Identities = 53/221 (23%), Positives = 94/221 (42%), Gaps = 22/221 (9%)
Query: 20 TAIYDKRRETDYSDKGYNLAFVSQDEQE--------NSSFTILYEEPLQEEDKYASAEAR 71
T ++ + E D G +L +D+Q+ S T + + E +KY +
Sbjct: 500 TIVHRLKDEETNEDSGRDLK-PHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
Query: 72 QTQSVLFHDTSADSMPVLA-CERSESRTDLVHH---FEKGTKLGETFDSDSSEM---FLS 124
Q S + S S+PV A + SE+ +V+H FE+ +L + +EM +
Sbjct: 559 QKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIE 618
Query: 125 VEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSL----LQ 180
+ K+ +ALS +DD+ + D LS EV+ + + S ++ S +SL Q
Sbjct: 619 TSINQPKV--VALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQ 676
Query: 181 SVSERLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGE 221
S + D + +E+E ++L GD+ S E
Sbjct: 677 DTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTE 717
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 37.4 bits (85), Expect = 0.073
Identities = 47/192 (24%), Positives = 73/192 (38%), Gaps = 33/192 (17%)
Query: 117 DSSEMFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPR------KSRDSEN 170
+ SE+ + E KR + P + EDD QE PG P+ K++
Sbjct: 899 EPSEISEASEEKRPR--PSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHR 956
Query: 171 QSSSVLSLLQSVSERLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDP 230
+S ++ S + S+ DE+D E +E+E+ EEA K + GE
Sbjct: 957 KSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGE--------- 1007
Query: 231 SITFYPDDQESVGISKNSYVMPNEPTTSNLQVGLWPEKTSFLQKSDLTSKLHSSLKSAYH 290
D+ES SK S ++ + TS + S +S SS S+
Sbjct: 1008 -------DEESDSSSKCSLYADSDGEN---------DSTSDSESSSSSSSSSSSSSSSSS 1051
Query: 291 QYLQTSQSHSSE 302
+S SSE
Sbjct: 1052 SSSSSSSESSSE 1063
Score = 32.3 bits (72), Expect = 2.3
Identities = 34/120 (28%), Positives = 44/120 (36%), Gaps = 32/120 (26%)
Query: 92 ERSESRTDLVHHFEKGTKL--GETFDSDSSEMFLSVEAKRYKIYPLALSPIYEDDSSQED 149
E E R + V +K T++ GE +SDSS +Y D + D
Sbjct: 985 EEDEDREEAVDTTKKETEVSDGEDEESDSSSK----------------CSLYADSDGEND 1028
Query: 150 ILSSEVSPGHHGPRKSRDSENQSSSVLSLLQSVSERLKMNFDEDDREAADEEEEEEEAAV 209
S S S S + SSS S +S SE DEEEEE AA+
Sbjct: 1029 STSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSE--------------DEEEEERPAAL 1074
>gi|56549656 ARKadia-like 1 isoform b [Homo sapiens]
Length = 343
Score = 37.4 bits (85), Expect = 0.073
Identities = 50/207 (24%), Positives = 80/207 (38%), Gaps = 16/207 (7%)
Query: 56 EEPLQEEDKYASAEARQTQSVLFHDTSADSMPVLACE--RSESRTDLVHHFEKGTKLGET 113
+E +EED E++ + + T SMP L E R S + L G
Sbjct: 25 QETAKEEDGSVELESQVQKDGVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRV 84
Query: 114 FDSDSS-EMFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGP---RKSRDSE 169
++SDSS LS + + LS E++ SQ + G G RKSR S
Sbjct: 85 YESDSSNHCMLSPSSSGHLADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSR 144
Query: 170 NQSSSVLSLLQSVSE----------RLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGS 219
++S + + + ++K + + +E ++ EAA K +L S
Sbjct: 145 SESETSTMAAKKNRQSSDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDS 204
Query: 220 GERVTFQLPDPSITFYPDDQESVGISK 246
+ D S + DD+E G SK
Sbjct: 205 STSDSDLTCDSSTSSSDDDEEVSGSSK 231
>gi|21450814 ARKadia-like 1 isoform a [Homo sapiens]
Length = 404
Score = 37.4 bits (85), Expect = 0.073
Identities = 50/207 (24%), Positives = 80/207 (38%), Gaps = 16/207 (7%)
Query: 56 EEPLQEEDKYASAEARQTQSVLFHDTSADSMPVLACE--RSESRTDLVHHFEKGTKLGET 113
+E +EED E++ + + T SMP L E R S + L G
Sbjct: 25 QETAKEEDGSVELESQVQKDGVADSTVISSMPCLLMELRRDSSESQLASTESDKPTTGRV 84
Query: 114 FDSDSS-EMFLSVEAKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGP---RKSRDSE 169
++SDSS LS + + LS E++ SQ + G G RKSR S
Sbjct: 85 YESDSSNHCMLSPSSSGHLADSDTLSSAEENEPSQAETAVEGDPSGVSGATVGRKSRRSR 144
Query: 170 NQSSSVLSLLQSVSE----------RLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGS 219
++S + + + ++K + + +E ++ EAA K +L S
Sbjct: 145 SESETSTMAAKKNRQSSDKQNGRVAKVKGHRSQKHKERIRLLRQKREAAARKKYNLLQDS 204
Query: 220 GERVTFQLPDPSITFYPDDQESVGISK 246
+ D S + DD+E G SK
Sbjct: 205 STSDSDLTCDSSTSSSDDDEEVSGSSK 231
>gi|188497637 cell division cycle associated 7-like isoform 3 [Homo
sapiens]
Length = 408
Score = 37.0 bits (84), Expect = 0.095
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 10/135 (7%)
Query: 127 AKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSLLQSVSERL 186
A RY+I P ++ I+ S E+ + P ++ SE S SL +S + +
Sbjct: 4 ATRYQI-PKEVADIFNAPSDDEEFVGFRDDV----PMETLSSEESCDSFDSL-ESGKQVV 57
Query: 187 KMNFDEDDREAA----DEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQESV 242
+ + +D + + +E+EEE++A R+ G RV FQ P + PD S
Sbjct: 58 ESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSS 117
Query: 243 GISKNSYVMPNEPTT 257
+S + NE T
Sbjct: 118 EQLFSSARLQNEKKT 132
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 37.0 bits (84), Expect = 0.095
Identities = 53/189 (28%), Positives = 76/189 (40%), Gaps = 29/189 (15%)
Query: 45 EQENSSFTILYEEPLQEEDKYASAEARQTQSVLFHDTSADSMPVLACERSESRTDLVHHF 104
++++ FT EE EED A+ E Q + + H A + LA E S +L+ +
Sbjct: 397 DEDDEEFTANEEEAEDEEDTIAAEE--QLEGEVDH---AMELSELAREGELSMEELLQQY 451
Query: 105 EKGTKLGETFDSDSSEMFLSVEAKRYKIYPL----ALSPIYEDDSSQEDILS--SEVSPG 158
G D E V+A P A P ED SSQ D + SE
Sbjct: 452 AGAYAPGSGSSEDEDED--EVDANSSDCEPEGPVEAEEPPQEDSSSQSDSVEDRSEDEED 509
Query: 159 HHGPRKSRDSENQSSSVLSLLQSVSERLKMNFDEDDREAADEEEEEEEAAVLH------- 211
H S + E SS +S SE + D + ADEEEE+++ V +
Sbjct: 510 EH----SEEEETSGSSASE--ESESEESE---DAQSQSQADEEEEDDDFGVEYLLARDEE 560
Query: 212 KGDLRAGSG 220
+ + AGSG
Sbjct: 561 QSEADAGSG 569
>gi|31657117 SMEK homolog 1, suppressor of mek1 [Homo sapiens]
Length = 820
Score = 36.6 bits (83), Expect = 0.12
Identities = 46/220 (20%), Positives = 95/220 (43%), Gaps = 18/220 (8%)
Query: 11 VRLDKRMSLTA-----IYDKRRETDYSD--KGYNLAFVSQDEQENSSFTILYEEPLQEED 63
+R++ SLTA + + DY KG L F Q E++++ L+
Sbjct: 595 IRVEDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNHR 654
Query: 64 KYASAEARQTQSVLFHDTSADSMP-----VLACERSESRTDLVHHFEKGTKLGETFDSDS 118
A + + ++ +T D M V +++++ D++ K + + +S+
Sbjct: 655 YRRDARTLEDEEEMWFNTDEDDMEDGEAVVSPSDKTKNDDDIMDPISKFMERKKLKESEE 714
Query: 119 SEMFL--SVEAKRYKIYPLALSPIYEDD----SSQEDILSSEVSPGHHGPRKSRDSENQS 172
E+ L ++ ++ + L+LS + + SS ++ S SPG G S S ++
Sbjct: 715 KEVLLKTNLSGRQSPSFKLSLSSGTKTNLTSQSSTTNLPGSPGSPGSPGSPGSPGSVPKN 774
Query: 173 SSVLSLLQSVSERLKMNFDEDDREAADEEEEEEEAAVLHK 212
+S + + + + + DD E DE+E++E+ L K
Sbjct: 775 TSQTAAITTKGGLVGLVDYPDDDEDDDEDEDKEDTLPLSK 814
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 36.2 bits (82), Expect = 0.16
Identities = 61/286 (21%), Positives = 109/286 (38%), Gaps = 27/286 (9%)
Query: 25 KRRETDYSDKGYNLAFVSQDEQENSSFTILYEEPLQEEDKYASAEARQTQSVLFHDTSAD 84
K+ E D +D L ++ E + T L + L+EE A + Q + H+ +
Sbjct: 1665 KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQ--AGRDEEQRLAAELHEQAQA 1722
Query: 85 ---SMPVLACERSESRTDLVHHFEKGTKLGETFDSDSSEMFLSVEAKRYKIYPLALSPIY 141
+LA E E R L E+ +L E +++E + ++ + L
Sbjct: 1723 LERRASLLAAELEELRAAL-EQGERSRRLAEQELLEATERLNLLHSQNTGL--LNQKKKL 1779
Query: 142 EDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSLL-------QSVS---ERLKMNFD 191
E D +Q LS EV R++ + ++ + +++ Q S ER+K +
Sbjct: 1780 EADLAQ---LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLE 1836
Query: 192 EDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQESVGISKNSYVM 251
+ RE EE E+AA LR G + + + D ++ V
Sbjct: 1837 QTVRELQARLEEAEQAA------LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVR 1890
Query: 252 PNEPTTSNLQVGLWPEKTSFLQKSDLTSKLHSSLKSAYHQYLQTSQ 297
+E L ++ + + DL KL S +KS Q+ + Q
Sbjct: 1891 KHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQ 1936
>gi|116174736 sentrin/SUMO-specific protease 7 isoform 2 [Homo
sapiens]
Length = 985
Score = 35.4 bits (80), Expect = 0.28
Identities = 49/225 (21%), Positives = 93/225 (41%), Gaps = 35/225 (15%)
Query: 69 EARQTQSVLFHDTSADSMPVLACERSESRTDLVHHFEKGTKLGETFDSDSSEMFLSVEAK 128
+A + QS TS DS+ C++ E ++ E+G++ +T D +S++ + K
Sbjct: 126 DANKVQSDSLPSTSVDSLET--CQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEK 183
Query: 129 RYKIYPLALSPIYEDDSSQEDILSSEVSPGH-HGPRKSRDSENQSSSV-LSLLQSVSERL 186
R K ++L D+ ED+ S H +++D + S V L+L+ ++R
Sbjct: 184 RRKDDGISL---LISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRR 240
Query: 187 KMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQESVGISK 246
N D + ++ E+ + ++ + PS ++ D +
Sbjct: 241 LRNNLPDSQYCTSLDKSTEQTK-------KQEDDSTISTEFEKPSENYHQDPK------- 286
Query: 247 NSYVMPNEPTTSNLQVGLWPEKTSFLQKSDLTSK---LHSSLKSA 288
+P E TT P K+ F + S L S+ L ++ KSA
Sbjct: 287 ----LPEEITTK-------PTKSDFTKLSSLNSQELTLSNATKSA 320
>gi|4505999 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 35.4 bits (80), Expect = 0.28
Identities = 32/122 (26%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 94 SESRTDLVHHFEKGTKLGETFDSD--SSEMFLSVEAKRYKIYPLALSPIYEDDSSQEDIL 151
+++ T + E+GT+ G+ + + E S + K+ +A S +ED + D
Sbjct: 208 AKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEA 267
Query: 152 SSEVSPGHHGPRKSRDSENQSSSVLSLLQSVSERLKMNFDEDDREAADEEEEEEEAAVLH 211
E DSE S SE + DEDD E A+E++EEEE ++
Sbjct: 268 EEE----------EEDSEECSEEEDGYS---SEEAENEEDEDDTEEAEEDDEEEEEEMMV 314
Query: 212 KG 213
G
Sbjct: 315 PG 316
>gi|29826282 protein phosphatase 1G [Homo sapiens]
Length = 546
Score = 35.4 bits (80), Expect = 0.28
Identities = 32/122 (26%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 94 SESRTDLVHHFEKGTKLGETFDSD--SSEMFLSVEAKRYKIYPLALSPIYEDDSSQEDIL 151
+++ T + E+GT+ G+ + + E S + K+ +A S +ED + D
Sbjct: 208 AKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEA 267
Query: 152 SSEVSPGHHGPRKSRDSENQSSSVLSLLQSVSERLKMNFDEDDREAADEEEEEEEAAVLH 211
E DSE S SE + DEDD E A+E++EEEE ++
Sbjct: 268 EEE----------EEDSEECSEEEDGYS---SEEAENEEDEDDTEEAEEDDEEEEEEMMV 314
Query: 212 KG 213
G
Sbjct: 315 PG 316
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 35.0 bits (79), Expect = 0.36
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 14/79 (17%)
Query: 142 EDDSSQEDILSSEVS-------PGHHGPRKSRDSENQSSSV-------LSLLQSVSERLK 187
ED QE +S EVS P +K+ ENQ S + + + S K
Sbjct: 1342 EDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENK 1401
Query: 188 MNFDEDDREAADEEEEEEE 206
N +E++ E +EEEEEEE
Sbjct: 1402 SNSEEEEEEKEEEEEEEEE 1420
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,565,432
Number of Sequences: 37866
Number of extensions: 1888961
Number of successful extensions: 8793
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 7865
Number of HSP's gapped (non-prelim): 543
length of query: 1022
length of database: 18,247,518
effective HSP length: 112
effective length of query: 910
effective length of database: 14,006,526
effective search space: 12745938660
effective search space used: 12745938660
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.