BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens] (261 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens] 525 e-149 gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens] 364 e-101 gi|194328732 Src-like-adaptor isoform c [Homo sapiens] 190 9e-49 gi|194328725 Src-like-adaptor isoform b [Homo sapiens] 190 9e-49 gi|113930754 Src-like-adaptor isoform a [Homo sapiens] 186 1e-47 gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 145 3e-35 gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 145 3e-35 gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 142 2e-34 gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 140 1e-33 gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 134 6e-32 gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 134 6e-32 gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 125 4e-29 gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 124 8e-29 gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 124 8e-29 gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 124 8e-29 gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 120 9e-28 gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 120 1e-27 gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 110 9e-25 gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 107 8e-24 gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 107 8e-24 gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 88 9e-18 gi|4503787 fyn-related kinase [Homo sapiens] 86 3e-17 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 77 2e-14 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 77 2e-14 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 77 2e-14 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 77 2e-14 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 77 2e-14 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 77 2e-14 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 77 2e-14 gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 76 3e-14 >gi|14149916 Src-like-adaptor 2 isoform a [Homo sapiens] Length = 261 Score = 525 bits (1351), Expect = e-149 Identities = 261/261 (100%), Positives = 261/261 (100%) Query: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT Sbjct: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60 Query: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI Sbjct: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120 Query: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA 180 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELA 180 Query: 181 DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEG 240 DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEG Sbjct: 181 DDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEG 240 Query: 241 LRESLSFYISLNDEAVSLDDA 261 LRESLSFYISLNDEAVSLDDA Sbjct: 241 LRESLSFYISLNDEAVSLDDA 261 >gi|28416424 Src-like-adaptor 2 isoform b [Homo sapiens] Length = 210 Score = 364 bits (934), Expect = e-101 Identities = 185/207 (89%), Positives = 188/207 (90%), Gaps = 7/207 (3%) Query: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT Sbjct: 1 MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLT 60 Query: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI Sbjct: 61 IVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLI 120 Query: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE-- 178 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSE Sbjct: 121 RESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSEGW 180 Query: 179 -----LADDICCLLKEPCVLQRAGPLP 200 C ++ L+RAG LP Sbjct: 181 PAPWQGYTPTCDCAEDTTQLERAGQLP 207 >gi|194328732 Src-like-adaptor isoform c [Homo sapiens] Length = 316 Score = 190 bits (483), Expect = 9e-49 Identities = 101/254 (39%), Positives = 147/254 (57%), Gaps = 10/254 (3%) Query: 5 PSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSE 64 P ++K + + S+ + P+ L +P+ + R GE L ++S+ Sbjct: 35 PGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD 94 Query: 65 DGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124 +G WW +S +GRE IP + VA+V HGWL+EGL R+KAEELL LP G+F+IRES+ Sbjct: 95 EGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESE 154 Query: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDIC 184 T++G YSLSVR +++HYRI L N W YISPRLTF L+ LV+HYSE+AD +C Sbjct: 155 TKKGFYSLSVR------HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLC 208 Query: 185 CLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATG----EESLLSEG 240 C+L PC+ Q + PVT+++ ++W+ + E +ESL S G Sbjct: 209 CVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYG 268 Query: 241 LRESLSFYISLNDE 254 LRES++ Y+SL E Sbjct: 269 LRESIASYLSLTSE 282 >gi|194328725 Src-like-adaptor isoform b [Homo sapiens] Length = 293 Score = 190 bits (483), Expect = 9e-49 Identities = 101/254 (39%), Positives = 147/254 (57%), Gaps = 10/254 (3%) Query: 5 PSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSE 64 P ++K + + S+ + P+ L +P+ + R GE L ++S+ Sbjct: 12 PGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD 71 Query: 65 DGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124 +G WW +S +GRE IP + VA+V HGWL+EGL R+KAEELL LP G+F+IRES+ Sbjct: 72 EGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESE 131 Query: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDIC 184 T++G YSLSVR +++HYRI L N W YISPRLTF L+ LV+HYSE+AD +C Sbjct: 132 TKKGFYSLSVR------HRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLC 185 Query: 185 CLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATG----EESLLSEG 240 C+L PC+ Q + PVT+++ ++W+ + E +ESL S G Sbjct: 186 CVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYG 245 Query: 241 LRESLSFYISLNDE 254 LRES++ Y+SL E Sbjct: 246 LRESIASYLSLTSE 259 >gi|113930754 Src-like-adaptor isoform a [Homo sapiens] Length = 276 Score = 186 bits (473), Expect = 1e-47 Identities = 97/219 (44%), Positives = 136/219 (62%), Gaps = 10/219 (4%) Query: 40 LGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGL 99 L +P+ + R GE L ++S++G WW +S +GRE IP + VA+V HGWL+EGL Sbjct: 30 LSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGL 89 Query: 100 SREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLY 159 R+KAEELL LP G+F+IRES+T++G YSLSVR +++HYRI L N W Y Sbjct: 90 GRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVR------HRQVKHYRIFRLPNNWYY 143 Query: 160 ISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKE 219 ISPRLTF L+ LV+HYSE+AD +CC+L PC+ Q + PVT+++ ++W+ Sbjct: 144 ISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRR 203 Query: 220 LDSSLLFSEAATG----EESLLSEGLRESLSFYISLNDE 254 + E +ESL S GLRES++ Y+SL E Sbjct: 204 VSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLTSE 242 >gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog isoform A [Homo sapiens] Length = 512 Score = 145 bits (367), Expect = 3e-35 Identities = 78/191 (40%), Positives = 114/191 (59%), Gaps = 5/191 (2%) Query: 6 SRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSED 65 S ++ P P S + GQ T + E VAL + P +LS + GE + ++ E Sbjct: 38 SNKQQRPVPE-SQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEH 96 Query: 66 GDWWTVLSEVSGREYNIPSVHVAKVS----HGWLYEGLSREKAEELLLLPGNPGGAFLIR 121 G+WW S ++ +E IPS +VAK++ W ++ ++R+ AE LL PGN GAFLIR Sbjct: 97 GEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIR 156 Query: 122 ESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELAD 181 ES+T +GS+SLSVR P D I+HY+I LDNG YISPR+TFP + ++ HY + AD Sbjct: 157 ESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQAD 216 Query: 182 DICCLLKEPCV 192 +C L++ C+ Sbjct: 217 GLCRRLEKACI 227 >gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog isoform B [Homo sapiens] Length = 491 Score = 145 bits (366), Expect = 3e-35 Identities = 78/188 (41%), Positives = 113/188 (60%), Gaps = 5/188 (2%) Query: 9 KSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDW 68 K+ P P S + GQ T + E VAL + P +LS + GE + ++ E G+W Sbjct: 20 KTQPVPE-SQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEW 78 Query: 69 WTVLSEVSGREYNIPSVHVAKVS----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQ 124 W S ++ +E IPS +VAK++ W ++ ++R+ AE LL PGN GAFLIRES+ Sbjct: 79 WKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESE 138 Query: 125 TRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDIC 184 T +GS+SLSVR P D I+HY+I LDNG YISPR+TFP + ++ HY + AD +C Sbjct: 139 TLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLC 198 Query: 185 CLLKEPCV 192 L++ C+ Sbjct: 199 RRLEKACI 206 >gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] Length = 526 Score = 142 bits (359), Expect = 2e-34 Identities = 78/185 (42%), Positives = 109/185 (58%), Gaps = 7/185 (3%) Query: 12 PSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTV 71 P P+ +S P EA VAL + A +LS + G+ + ++ E G+WW Sbjct: 61 PGPNSHNS---NTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKA 117 Query: 72 LSEVSGREYNIPSVHVAKV----SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRR 127 S + +E IPS +VA+V + W ++G+SR+ AE LL PGN G+F+IR+S+T + Sbjct: 118 RSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTK 177 Query: 128 GSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLL 187 GSYSLSVR P D ++HY+I LDNG YISPR TF +LQ LVDHY + D +C L Sbjct: 178 GSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKL 237 Query: 188 KEPCV 192 PC+ Sbjct: 238 SVPCM 242 >gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] Length = 505 Score = 140 bits (352), Expect = 1e-33 Identities = 76/172 (44%), Positives = 100/172 (58%), Gaps = 5/172 (2%) Query: 25 PVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPS 84 P + K VAL + A +L + GE L ++ GDWW S V+GRE +PS Sbjct: 51 PPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPS 110 Query: 85 VHVAKVS----HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPA 140 VA+V W + R++AE LL P N G+FLIRES+T +G++SLSV+ Sbjct: 111 NFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVK-DVTT 169 Query: 141 SWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCV 192 + I+HY+I CLD G YISPR+TFPSLQALV HYS+ D +C L PCV Sbjct: 170 QGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCV 221 >gi|112789548 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 134 bits (338), Expect = 6e-32 Identities = 70/162 (43%), Positives = 95/162 (58%), Gaps = 4/162 (2%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVS----HG 93 +AL S+ +L GE L I+ + G+WW S +G+E IP VAK + Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP 126 Query: 94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 153 W ++ LSR+ AE LL PGN G+FLIRES++ GS+SLSVR + ++HY+I L Sbjct: 127 WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNL 186 Query: 154 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQR 195 DNG YISPR+TFP L LV HY+ +D +C L PC Q+ Sbjct: 187 DNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQK 228 >gi|112789546 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 134 bits (338), Expect = 6e-32 Identities = 70/162 (43%), Positives = 95/162 (58%), Gaps = 4/162 (2%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVS----HG 93 +AL S+ +L GE L I+ + G+WW S +G+E IP VAK + Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP 126 Query: 94 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 153 W ++ LSR+ AE LL PGN G+FLIRES++ GS+SLSVR + ++HY+I L Sbjct: 127 WFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNL 186 Query: 154 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQR 195 DNG YISPR+TFP L LV HY+ +D +C L PC Q+ Sbjct: 187 DNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQK 228 >gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] Length = 537 Score = 125 bits (314), Expect = 4e-29 Identities = 72/159 (45%), Positives = 91/159 (57%), Gaps = 5/159 (3%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV-SEDGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 VAL + A +LS GE I+ S +GDWW S +G IPS +VA V + Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + L R+ AE LL GNP G FLIRES+T +G+YSLS+R D ++HY+I Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207 Query: 153 LDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 191 LDNG YI+ R F +LQ LV HYSE A +CC L PC Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPC 246 >gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] Length = 529 Score = 124 bits (311), Expect = 8e-29 Identities = 69/163 (42%), Positives = 96/163 (58%), Gaps = 5/163 (3%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 +AL + A +L+ GE I++ +GDWW S SG+ IPS +VA V + Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + + R+ AE LL PGNP GAFLIRES+T +G+YSLS+R D ++HY+I Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202 Query: 153 LDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQR 195 LD G YI+ R+ F S+Q LV HY E+ D +C LL PC + + Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK 245 >gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] Length = 529 Score = 124 bits (311), Expect = 8e-29 Identities = 69/163 (42%), Positives = 96/163 (58%), Gaps = 5/163 (3%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 +AL + A +L+ GE I++ +GDWW S SG+ IPS +VA V + Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + + R+ AE LL PGNP GAFLIRES+T +G+YSLS+R D ++HY+I Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202 Query: 153 LDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQR 195 LD G YI+ R+ F S+Q LV HY E+ D +C LL PC + + Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK 245 >gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapiens] Length = 529 Score = 124 bits (311), Expect = 8e-29 Identities = 69/163 (42%), Positives = 96/163 (58%), Gaps = 5/163 (3%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 +AL + A +L+ GE I++ +GDWW S SG+ IPS +VA V + Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + + R+ AE LL PGNP GAFLIRES+T +G+YSLS+R D ++HY+I Sbjct: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202 Query: 153 LDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQR 195 LD G YI+ R+ F S+Q LV HY E+ D +C LL PC + + Sbjct: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK 245 >gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] Length = 534 Score = 120 bits (302), Expect = 9e-28 Identities = 72/168 (42%), Positives = 94/168 (55%), Gaps = 8/168 (4%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV-SEDGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 VAL + A +LS GE I+ S +GDWW S +G IPS +VA V + Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + L R+ AE LL GNP G FLIRES+T +G+YSLS+R D ++HY+I Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207 Query: 153 LDNGWLYISPRLTFPSLQALVDHYSELADDIC---CLLKEPCVLQRAG 197 LDNG YI+ R F +LQ LV HYSE AD +C ++ C Q +G Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSG 255 >gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] Length = 543 Score = 120 bits (301), Expect = 1e-27 Identities = 67/159 (42%), Positives = 92/159 (57%), Gaps = 5/159 (3%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 VAL + A +LS + GE I++ +GDWW S +G+ IPS +VA + Sbjct: 97 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + + R+ AE LLL PGN G FL+RES+T +G+YSLS+R D ++HY+I Sbjct: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216 Query: 153 LDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 191 LDNG YI+ R F +LQ LV HY+E AD +C L C Sbjct: 217 LDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVC 255 >gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] Length = 482 Score = 110 bits (276), Expect = 9e-25 Identities = 65/145 (44%), Positives = 83/145 (57%), Gaps = 5/145 (3%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV-SEDGDWWTVLSEVSGREYNIPSVHVAKV----SH 92 VAL + A +LS GE I+ S +GDWW S +G IPS +VA V + Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAE 147 Query: 93 GWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHC 152 W + L R+ AE LL GNP G FLIRES+T +G+YSLS+R D ++HY+I Sbjct: 148 EWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRK 207 Query: 153 LDNGWLYISPRLTFPSLQALVDHYS 177 LDNG YI+ R F +LQ LV HYS Sbjct: 208 LDNGGYYITTRAQFETLQQLVQHYS 232 >gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] Length = 536 Score = 107 bits (268), Expect = 8e-24 Identities = 65/161 (40%), Positives = 92/161 (57%), Gaps = 5/161 (3%) Query: 36 TAVALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV---- 90 T VAL + + +LS + GE L IV+ +GDWW S +G+ IPS +VA Sbjct: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147 Query: 91 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150 + W + ++R ++E LLL NP G FL+RES+T +G+Y LSV A ++HY+I Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207 Query: 151 HCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 191 LD+G YI+ R F SLQ LV +YS+ AD +C L C Sbjct: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 >gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapiens] Length = 536 Score = 107 bits (268), Expect = 8e-24 Identities = 65/161 (40%), Positives = 92/161 (57%), Gaps = 5/161 (3%) Query: 36 TAVALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV---- 90 T VAL + + +LS + GE L IV+ +GDWW S +G+ IPS +VA Sbjct: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147 Query: 91 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150 + W + ++R ++E LLL NP G FL+RES+T +G+Y LSV A ++HY+I Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207 Query: 151 HCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 191 LD+G YI+ R F SLQ LV +YS+ AD +C L C Sbjct: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 >gi|18250298 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [Homo sapiens] Length = 488 Score = 87.8 bits (216), Expect = 9e-18 Identities = 63/175 (36%), Positives = 92/175 (52%), Gaps = 17/175 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYN--IPSVHVAKVS---- 91 +AL F A ELS+R G+ L + E+G + +SG+ +P HVAK S Sbjct: 57 LALYDFTARCGGELSVRRGDRLCAL-EEGGGYIFARRLSGQPSAGLVPITHVAKASPETL 115 Query: 92 --HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYR 149 W + G+SR +A++LLL P N GAFLIR S++ G YSLSVR ++ HYR Sbjct: 116 SDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQA-----KVCHYR 170 Query: 150 IHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDI 204 + +G LY+ FP L+ L+ +Y I L +PC+ Q+A P +D+ Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKA---PRQDV 222 >gi|4503787 fyn-related kinase [Homo sapiens] Length = 505 Score = 85.9 bits (211), Expect = 3e-17 Identities = 64/227 (28%), Positives = 107/227 (47%), Gaps = 27/227 (11%) Query: 29 EAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYN------- 81 +++R VAL + A +LS R G+ L ++ + W + R Sbjct: 39 QSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQG 98 Query: 82 -IPSVHVAK----VSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRL 136 IPS +VA+ + W + + R AE+ LL N G+FLIRES++++G +SLSV Sbjct: 99 YIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSV-- 156 Query: 137 SRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRA 196 ++HYRI LD G +++ R F +L V HY++ +D +C L +PC+ + Sbjct: 157 ---LDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQ- 212 Query: 197 GPLPGKDIPLPVTVQRTPLNWKELD--SSLLFSEAATGEESLLSEGL 241 +P P + ++ E+D S L +G+ + EGL Sbjct: 213 -------VPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGL 252 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 77.0 bits (188), Expect = 2e-14 Identities = 54/159 (33%), Positives = 85/159 (53%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ + +G+W ++ +G+ + +PS ++ V+ Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 124 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 125 HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 177 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G LY+S F +L LV H+S +AD + L P Sbjct: 178 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 216 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 77.0 bits (188), Expect = 2e-14 Identities = 54/159 (33%), Positives = 85/159 (53%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ + +G+W ++ +G+ + +PS ++ V+ Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTK-NGQGW-VPSNYITPVNSLEK 143 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 144 HSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYE-----GRVYHYRIN 196 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G LY+S F +L LV H+S +AD + L P Sbjct: 197 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP 235 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 77.0 bits (188), Expect = 2e-14 Identities = 55/159 (34%), Positives = 88/159 (55%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+ Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 155 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 208 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G +Y++ F +L LV H+S +AD + L P Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 247 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 77.0 bits (188), Expect = 2e-14 Identities = 55/159 (34%), Positives = 88/159 (55%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+ Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 170 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 223 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G +Y++ F +L LV H+S +AD + L P Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 262 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 77.0 bits (188), Expect = 2e-14 Identities = 55/159 (34%), Positives = 88/159 (55%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+ Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 149 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 150 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 202 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G +Y++ F +L LV H+S +AD + L P Sbjct: 203 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 241 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 77.0 bits (188), Expect = 2e-14 Identities = 55/159 (34%), Positives = 88/159 (55%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+ Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 155 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 208 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G +Y++ F +L LV H+S +AD + L P Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 247 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 77.0 bits (188), Expect = 2e-14 Identities = 55/159 (34%), Positives = 88/159 (55%), Gaps = 15/159 (9%) Query: 38 VALGSFPAGGPAELSLRLGEPLTIV--SEDGDWWTVLSEVSGREYNIPSVHVAKVS---- 91 VAL F A G LS+ GE L ++ +++G+W V S+ +G+ + +PS ++ V+ Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSK-NGQGW-VPSNYITPVNSLEK 134 Query: 92 HGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIH 151 H W + +SR AE LL N G+FL+RES++ G S+S+R R+ HYRI+ Sbjct: 135 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYE-----GRVYHYRIN 187 Query: 152 CLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 190 +G +Y++ F +L LV H+S +AD + L P Sbjct: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP 226 >gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] Length = 330 Score = 76.3 bits (186), Expect = 3e-14 Identities = 52/140 (37%), Positives = 74/140 (52%), Gaps = 10/140 (7%) Query: 37 AVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLY 96 AVA F A G ELS G+ L I+S +W+ +E+ +E +P + W + Sbjct: 3 AVAKFDFTASGEDELSFHTGDVLKILSNQEEWFK--AELGSQEGYVPKNFIDIQFPKWFH 60 Query: 97 EGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNG 156 EGLSR +AE LL+ G G F+IR SQ+ G +S+SVR D ++H+++ DN Sbjct: 61 EGLSRHQAENLLM--GKEVGFFIIRASQSSPGDFSISVRHE-----DDVQHFKV-MRDNK 112 Query: 157 WLYISPRLTFPSLQALVDHY 176 Y FPSL LVD+Y Sbjct: 113 GNYFLWTEKFPSLNKLVDYY 132 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.133 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,055,386 Number of Sequences: 37866 Number of extensions: 543928 Number of successful extensions: 1496 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 104 Number of HSP's successfully gapped in prelim test: 79 Number of HSP's that attempted gapping in prelim test: 1293 Number of HSP's gapped (non-prelim): 205 length of query: 261 length of database: 18,247,518 effective HSP length: 100 effective length of query: 161 effective length of database: 14,460,918 effective search space: 2328207798 effective search space used: 2328207798 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.