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Search of human proteins with 14149613
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
(1477 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 2999 0.0
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 2959 0.0
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 1900 0.0
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 1894 0.0
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 1691 0.0
gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens] 704 0.0
gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens] 488 e-137
gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens] 466 e-131
gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens] 366 e-101
gi|47519929 cell recognition molecule CASPR3 [Homo sapiens] 219 1e-56
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 216 2e-55
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 166 1e-40
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 164 6e-40
gi|54873613 agrin [Homo sapiens] 137 6e-32
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 134 5e-31
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 134 8e-31
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 131 4e-30
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 131 4e-30
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 127 6e-29
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 127 1e-28
gi|239743797 PREDICTED: similar to cell recognition molecule CAS... 114 5e-25
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 114 5e-25
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 105 2e-22
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 104 6e-22
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 102 2e-21
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 97 2e-19
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 91 8e-18
gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 87 9e-17
gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens] 87 9e-17
gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 87 9e-17
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 2999 bits (7774), Expect = 0.0
Identities = 1477/1477 (100%), Positives = 1477/1477 (100%)
Query: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT
Sbjct: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
Query: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR
Sbjct: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
Query: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF
Sbjct: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
Query: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ
Sbjct: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
Query: 241 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 300
AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP
Sbjct: 241 AVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP 300
Query: 301 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 360
IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG
Sbjct: 301 IQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNG 360
Query: 361 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 420
KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP
Sbjct: 361 KFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSP 420
Query: 421 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 480
STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD
Sbjct: 421 STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLD 480
Query: 481 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 540
PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF
Sbjct: 481 PITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDF 540
Query: 541 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 600
FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA
Sbjct: 541 FAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTA 600
Query: 601 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 660
PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA
Sbjct: 601 PGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMA 660
Query: 661 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 720
EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS
Sbjct: 661 EVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLS 720
Query: 721 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 780
YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV
Sbjct: 721 YDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTV 780
Query: 781 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 840
NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT
Sbjct: 781 NLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHT 840
Query: 841 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 900
RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR
Sbjct: 841 RLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFR 900
Query: 901 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 960
NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG
Sbjct: 901 NIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG 960
Query: 961 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 1020
YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL
Sbjct: 961 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNL 1020
Query: 1021 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1080
DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC
Sbjct: 1021 DLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC 1080
Query: 1081 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1140
EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP
Sbjct: 1081 EGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWP 1140
Query: 1141 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1200
PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI
Sbjct: 1141 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAI 1200
Query: 1201 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQG 1260
EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQG
Sbjct: 1201 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQG 1260
Query: 1261 QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS 1320
QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS
Sbjct: 1261 QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS 1320
Query: 1321 IMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTR 1380
IMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTR
Sbjct: 1321 IMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTR 1380
Query: 1381 AGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRN 1440
AGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRN
Sbjct: 1381 AGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRN 1440
Query: 1441 YISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
YISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Sbjct: 1441 YISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 2959 bits (7671), Expect = 0.0
Identities = 1477/1547 (95%), Positives = 1477/1547 (95%), Gaps = 70/1547 (4%)
Query: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT
Sbjct: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
Query: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR
Sbjct: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
Query: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF
Sbjct: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
Query: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ
Sbjct: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
Query: 241 AVCDCSRTGFRGKDCSQE---------------------------------DNNVEGLAH 267
AVCDCSRTGFRGKDCSQE DNNVEGLAH
Sbjct: 241 AVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAH 300
Query: 268 LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 327
LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS
Sbjct: 301 LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
Query: 328 ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 387
ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV
Sbjct: 361 ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 420
Query: 388 -------TISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 440
TISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE
Sbjct: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 480
Query: 441 VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK 500
VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK
Sbjct: 481 VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK 540
Query: 501 TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT 560
TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT
Sbjct: 541 TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT 600
Query: 561 IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE 620
IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE
Sbjct: 601 IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE 660
Query: 621 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 680
NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC
Sbjct: 661 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 720
Query: 681 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 740
LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE
Sbjct: 721 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 780
Query: 741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 800
DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA
Sbjct: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 840
Query: 801 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 860
GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS
Sbjct: 841 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 900
Query: 861 VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT 920
VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT
Sbjct: 901 VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT 960
Query: 921 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN 980
LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN
Sbjct: 961 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN 1020
Query: 981 KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP 1040
KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP
Sbjct: 1021 KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP 1080
Query: 1041 KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ 1100
KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ
Sbjct: 1081 KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ 1140
Query: 1101 QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ 1160
QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ
Sbjct: 1141 QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ 1200
Query: 1161 KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS 1220
KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS
Sbjct: 1201 KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS 1260
Query: 1221 GGNATLQVDSWPVIERYPA------------------------------GRQLTIFNSQA 1250
GGNATLQVDSWPVIERYPA GRQLTIFNSQA
Sbjct: 1261 GGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA 1320
Query: 1251 TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA 1310
TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA
Sbjct: 1321 TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA 1380
Query: 1311 TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP 1370
TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP
Sbjct: 1381 TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP 1440
Query: 1371 SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE 1430
SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE
Sbjct: 1441 SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE 1500
Query: 1431 GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Sbjct: 1501 GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 1900 bits (4923), Expect = 0.0
Identities = 934/1369 (68%), Positives = 1118/1369 (81%), Gaps = 43/1369 (3%)
Query: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
Query: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
Query: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
Query: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
Query: 249 GFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEI 308
GF GK CS+E++ +EG AHL + S+GKEE++ATFKG+E+FCYDLS NPIQSS+DEI
Sbjct: 235 GFGGKFCSEEEHPMEGPAHLTLN----SEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEI 290
Query: 309 TLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWH 368
TL+F+TLQRNGLMLHTGKSADYVNL+LK+GAV LVINLGSGAFEALVEPVNGKFNDNAWH
Sbjct: 291 TLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWH 350
Query: 369 DVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS 428
DV+VTRNLRQH+GIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFY+GGSP+TADLPGS
Sbjct: 351 DVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGS 410
Query: 429 PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE 488
PVSNNFMGCLK+VVYKNND +LELSRLAK+GDPKMK+ G ++F+CE+VA LDP+TFE+PE
Sbjct: 411 PVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPE 470
Query: 489 SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG 548
+F++LP+W+AK+TGSIS DFRTTEPNGL+LFS G+ H + D+FA+E+LDG
Sbjct: 471 AFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDG 530
Query: 549 HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 608
HLYLLLDMGSG IK++A +KVNDGEW HVDFQRDGR G+ISVN+ TP+ A G+SEILD
Sbjct: 531 HLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILD 590
Query: 609 LDDELYLGGLPEN-KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAG 667
L+ ELYLGGLPE + L P EVWTA L GYVGC+RDLFIDG+S+D+R +AE Q G
Sbjct: 591 LESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVG 650
Query: 668 VKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFM 727
V P CS+ET K C S PC+N G+CR+GWNR++CDC GTG+LGR CEREATVLSYDGSM+M
Sbjct: 651 VAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYM 710
Query: 728 KIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRI 787
KI LP MHTEAEDVSLRF SQRAYG++MATTSR+SADTLRLELD G++KLTVNL
Sbjct: 711 KIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNL----- 765
Query: 788 NCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI 847
KGPETLFAG+ LNDNEWHTVRVVRRGKSL+L+VD+ + GQMAG H RLEFHNI
Sbjct: 766 ----GKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNV-TVEGQMAGAHMRLEFHNI 820
Query: 848 ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPV 907
ETGI+TERR++S VPSNFIGHL L FNG Y+D CK+GDI YCELNARFG R I+ADPV
Sbjct: 821 ETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPV 880
Query: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFD 967
TFK++SSY+ALATLQAY SMHLFFQFKTT+ DGL+L+NSG+GNDFIV+ELVKGY+HYVFD
Sbjct: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFD 940
Query: 968 LGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLY 1027
LGNG +L+KG+S+KP+NDNQWHNV++SRD N+HT+KID++ TQ + GARNLDLK +LY
Sbjct: 941 LGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELY 1000
Query: 1028 IGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTC 1087
IGG++K + +LPKLV +++GFQGCLASVDLNGRLPDLI+DAL GQ+ERGC+GPSTTC
Sbjct: 1001 IGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTC 1060
Query: 1088 QEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPST 1147
E+SC+NQGVCLQQWDGF+CDC+MTS+ GP+CNDPGTTYIF KGG ITY WPPNDRPST
Sbjct: 1061 TEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPST 1120
Query: 1148 RADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAII 1207
R DRLA+GFST Q+ AVLVRVDS+SGLGDYL+LHI QG +GV FNVGTDDI I+E NAI+
Sbjct: 1121 RMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIV 1180
Query: 1208 NDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQGQPFQGQL 1267
+DGKYHVVRFTRSGGNATLQVDSWPV ERYPAGRQLTIFNSQA I IGG++QG+PFQGQ+
Sbjct: 1181 SDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQV 1240
Query: 1268 SGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTT 1326
SGLYYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTT
Sbjct: 1241 SGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTT 1300
Query: 1327 TLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1374
T+AT+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 1301 TMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1349
Score = 164 bits (416), Expect = 4e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1376 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1435
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1542 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
Query: 1436 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 1894 bits (4905), Expect = 0.0
Identities = 941/1426 (65%), Positives = 1128/1426 (79%), Gaps = 87/1426 (6%)
Query: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
Query: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
Query: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
Query: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
Query: 249 GFRGKDCSQEDNNVEGLAHLMM-----------GDQGK---------SKGKEEYIATFKG 288
GF GK CS+E++ +EG AHL + G G+ +KGKEE++ATFKG
Sbjct: 235 GFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKG 294
Query: 289 SEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGS 348
+E+FCYDLS NPIQSS+DEITL+F+TLQRNGLMLHTGKSADYVNL+LK+GAV LVINLGS
Sbjct: 295 NEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGS 354
Query: 349 GAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV-------TISVDGILTTTGYT 401
GAFEALVEPVNGKFNDNAWHDV+VTRNLRQH+GIGHAMV TISVDGILTTTGYT
Sbjct: 355 GAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYT 414
Query: 402 QEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDP 461
QEDYTMLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND +LELSRLAK+GDP
Sbjct: 415 QEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDP 474
Query: 462 KMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSH 521
KMK+ G ++F+CE+VA LDP+TFE+PE+F++LP+W+AK+TGSIS DFRTTEPNGL+LFS
Sbjct: 475 KMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQ 534
Query: 522 GKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQ 581
G+ H + D+FA+E+LDGHLYLLLDMGSG IK++A +KVNDGEW HVDFQ
Sbjct: 535 GRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQ 594
Query: 582 RDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN-KAGLVFPTEVWTALLNYGY 640
RDGR G+ISVN+ TP+ A G+SEILDL+ ELYLGGLPE + L P EVWTA L GY
Sbjct: 595 RDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGY 654
Query: 641 VGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVC 700
VGC+RDLFIDG+S+D+R +AE Q GV P CS+ET K C S PC+N G+CR+GWNR++C
Sbjct: 655 VGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFIC 714
Query: 701 DCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTS 760
DC GTG+LGR CEREATVLSYDGSM+MKI LP MHTEAEDVSLRF SQRAYG++MATTS
Sbjct: 715 DCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTS 774
Query: 761 RDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKS 820
R+SADTLRLELD G++KLTVNLDC+R+ C SKGPETLFAG+ LNDNEWHTVRVVRRGKS
Sbjct: 775 RESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKS 834
Query: 821 LKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYI 880
L+L+VD+ + GQMAG H RLEFHNIETGI+TERR++S VPSNFIGHL L FNG Y+
Sbjct: 835 LQLSVDNV-TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYM 893
Query: 881 DLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDG 940
D CK+GDI YCELNARFG R I+ADPVTFK++SSY+ALATLQAY SMHLFFQFKTT+ DG
Sbjct: 894 DQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDG 953
Query: 941 LILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNL 1000
L+L+NSG+GNDFIV+ELVKGY+HYVFDLGNG +L+KG+S+KP+NDNQWHNV++SRD N+
Sbjct: 954 LLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNV 1013
Query: 1001 HTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNG 1060
HT+KID++ TQ + GARNLDLK +LYIGG++K + +LPKLV +++GFQGCLASVDLNG
Sbjct: 1014 HTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG 1073
Query: 1061 RLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
RLPDLI+DAL GQ+ERGC+GPSTTC E+SC+NQGVCLQQWDGF+CDC+MTS+ GP+CN
Sbjct: 1074 RLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1133
Query: 1121 DPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLEL 1180
DPGTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVRVDS+SGLGDYL+L
Sbjct: 1134 DPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQL 1193
Query: 1181 HIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPA- 1239
HI QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQVDSWPV ERYPA
Sbjct: 1194 HIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG 1253
Query: 1240 -----------------------------GRQLTIFNSQATIIIGGKEQGQPFQGQLSGL 1270
GRQLTIFNSQA I IGG++QG+PFQGQ+SGL
Sbjct: 1254 NFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGL 1313
Query: 1271 YYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTTTLA 1329
YYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTTT+A
Sbjct: 1314 YYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMA 1373
Query: 1330 TSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1374
T+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 1374 TTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1419
Score = 164 bits (416), Expect = 4e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1376 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1435
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1612 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
Query: 1436 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 1691 bits (4379), Expect = 0.0
Identities = 820/1071 (76%), Positives = 939/1071 (87%), Gaps = 10/1071 (0%)
Query: 407 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIH 466
MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNND+RLELSRLA+ D KMKI+
Sbjct: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
Query: 467 GVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRH 526
G V FKCENVATLDPI FETPE++ISLPKWN K+ GSISFDFRTTEPNGLILF+HGKP+
Sbjct: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
Query: 527 QKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRS 586
+KDA+ + KVDFFA+E+LDG+LYLLLDMGSGTIK+KA KK NDGEWYHVD QRDGRS
Sbjct: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
Query: 587 GTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRD 646
GTISVN+ RTP+TA GESEILDL+ ++YLGGLPEN+AGL+ PTE+WTA+LNYGYVGCIRD
Sbjct: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD 240
Query: 647 LFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTG 706
LFIDG+SK+IRQ+AE+Q+ AGVK SCS+ +AK C S PCKNN +C+DGWNR++CDC+GTG
Sbjct: 241 LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG 300
Query: 707 YLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADT 766
Y GR+CEREA++LSYDGSM+MKI +P+VMHTEAEDVS RF SQRAYG+L+ATTSRDSADT
Sbjct: 301 YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT 360
Query: 767 LRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVD 826
LRLELD GRVKL VNLDCIRINCNSSKGPETL+AG LNDNEWHTVRVVRRGKSLKLTVD
Sbjct: 361 LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD 420
Query: 827 DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNG 886
D A G M GDHTRLEFHNIETGI+TE+RY+S VPS+FIGHLQSL FNG+ YIDLCKNG
Sbjct: 421 DDVA-EGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
Query: 887 DIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 946
DIDYCEL ARFG RNIIADPVTFKTKSSY++LATLQAYTSMHLFFQFKTTS DG IL+NS
Sbjct: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
Query: 947 GDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKID 1006
GDGNDFI VELVKGY+HYVFDLGNG N+IKG+S++PLNDNQWHNV+I+RD SN H++K+D
Sbjct: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
Query: 1007 TKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLI 1066
TK+ TQ+ GA+NLDLK DLY+ G+A+ Y +LPKLV +++GFQGCLASVDLNGRLPDLI
Sbjct: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
Query: 1067 SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTY 1126
+DAL +GQIERGCEGPSTTCQEDSC+NQGVC+QQW+GF+CDCSMTS+SG CNDPG TY
Sbjct: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
Query: 1127 IFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGK 1186
IF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI QGK
Sbjct: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
Query: 1187 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIF 1246
IGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP GRQLTIF
Sbjct: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIF 839
Query: 1247 NSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTT 1306
N+QA I IGGK++G+ FQGQLSGLYY+GLKVLNMAAEN+ NI I G+VRLVGEVPS + T
Sbjct: 840 NTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGT 899
Query: 1307 ESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDID 1366
T T+M EMST++METTTT+AT+T R+ + Q T D LV+SAEC SDDED
Sbjct: 900 TQT-TSMPPEMSTTVMETTTTMATTTTRKNRSTAS---IQPTSDDLVSSAECSSDDEDFV 955
Query: 1367 PCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYR 1426
CEPS+ ANPT G R PG++EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYR
Sbjct: 956 ECEPST---ANPTEPGIRR-VPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYR 1011
Query: 1427 NRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
NRDEGSY VDE+RNYISNSAQSNG ++KEKQ SS KS +K +KNKD+EYYV
Sbjct: 1012 NRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
Score = 195 bits (496), Expect = 2e-49
Identities = 195/815 (23%), Positives = 342/815 (41%), Gaps = 110/815 (13%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGF------------CDFLELILTRGGRLQL 91
PKWN +SF +T GL+L+ + DF + L G L L
Sbjct: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELL-DGNLYL 146
Query: 92 SFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
+ NDG W+ V I+R R+ T+ ++ + + + +
Sbjct: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT-ASGESEILDLEG 205
Query: 152 GLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNS 211
+++GGLP L L + + G IRD+ ++ S ++ E N+
Sbjct: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR------SKNIRQLAEMQNA 259
Query: 212 GG-GSPCE--AGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHL 268
G S C + ++ + C N VC ++ +CDC+ TG+ G+ C +E +
Sbjct: 260 AGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREAS-------- 311
Query: 269 MMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-- 326
I ++ GS Y + + + +++++ F + + GL++ T
Sbjct: 312 --------------ILSYDGSMYMKI-IMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRD 356
Query: 327 SADYVNLALKNGAVSLVINL--------GSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQ 378
SAD + L L G V L++NL S E L K NDN WH V+V R +
Sbjct: 357 SADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLY--AGQKLNDNEWHTVRVVRRGKS 414
Query: 379 HSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
+T+ D G D+T L +F + T S V ++F+G L
Sbjct: 415 ------LKLTVDDD---VAEGTMVGDHTRL---EFHNIETGIMTEKRYISVVPSSFIGHL 462
Query: 439 KEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNA 498
+ +++ L L K GD F N+ DP+TF+T S++SL A
Sbjct: 463 QSLMFNG----LLYIDLCKNGDIDY-CELKARFGLRNIIA-DPVTFKTKSSYLSLATLQA 516
Query: 499 KKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGS 558
+ + F F+TT P+G ILF+ G DF A+E++ G+++ + D+G+
Sbjct: 517 YTSMHLFFQFKTTSPDGFILFNSGDGN-------------DFIAVELVKGYIHYVFDLGN 563
Query: 559 GTIKIKALL-KKVNDGEWYHVDFQRD-GRSGTISVNTLRTPYTAPGESEILDLDDELYLG 616
G IK + +ND +W++V RD + ++ V+T G ++ LDL +LY+
Sbjct: 564 GPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVING-AKNLDLKGDLYMA 622
Query: 617 GLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKET 676
GL + ++ G+ GC+ + ++G+ D+ A + + ++ C +
Sbjct: 623 GLAQG----MYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDA-LHRSGQIERGC-EGP 676
Query: 677 AKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC-EREATVLSYDGSMFMKIQLPV-- 733
+ C + C N G+C W + CDCS T Y G C + AT + + P
Sbjct: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
Query: 734 VMHTEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSS 792
T ++ +++ F + GIL+ S D L+L ++ G++ + N+ + I+
Sbjct: 737 RPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEE 796
Query: 793 KGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 827
+ P +ND ++H VR R G + L VD+
Sbjct: 797 RTP--------VNDGKYHVVRFTRNGGNATLQVDN 823
>gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens]
Length = 442
Score = 704 bits (1817), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 1123 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1182
GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI
Sbjct: 88 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 147
Query: 1183 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQ 1242
HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQ
Sbjct: 148 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQ 207
Query: 1243 LTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS 1302
LTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS
Sbjct: 208 LTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS 267
Query: 1303 SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDD 1362
SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDD
Sbjct: 268 SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDD 327
Query: 1363 EDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM 1422
EDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM
Sbjct: 328 EDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM 387
Query: 1423 YKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
YKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Sbjct: 388 YKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 442
Score = 42.7 bits (99), Expect = 0.003
Identities = 48/188 (25%), Positives = 78/188 (41%), Gaps = 28/188 (14%)
Query: 287 KGSEYFCYDLSQNPIQSS-SDEITLSFKTLQRNGLMLHTGKSA---DYVNLALKNGAVSL 342
KG Y N S+ +D + + F T+Q+ +++ S+ DY+ L + G + +
Sbjct: 95 KGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGV 154
Query: 343 VINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGY-T 401
N+G+ + +E N ND +H V+ TR SG G+A T+ VD Y
Sbjct: 155 KFNVGTD--DIAIEESNAIINDGKYHVVRFTR-----SG-GNA--TLQVDSWPVIERYPA 204
Query: 402 QEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDP 461
T+ S +GG G P F G L + Y L++ +A + D
Sbjct: 205 GRQLTIFNSQATIIIGGKEQ-----GQP----FQGQLSGLYYNG----LKVLNMAAENDA 251
Query: 462 KMKIHGVV 469
+ I G V
Sbjct: 252 NIAIVGNV 259
Score = 40.4 bits (93), Expect = 0.013
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 25/155 (16%)
Query: 66 LVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRN 125
LV G D+LEL + +G ++ + F++ + A ++ +NDG +H VR R N
Sbjct: 130 LVRVDSSSGLGDYLELHIHQG-KIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGN 188
Query: 126 TTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIR 185
TL +D +E R +T+F+ + + + + +PF+G +
Sbjct: 189 ATLQVDSWPV--IERYPAGRQLTIFN-------------SQATIIIGGKEQGQPFQGQLS 233
Query: 186 DVRVNSSQVLPVDS---------GEVKLDDEPPNS 211
+ N +VL + + G V+L E P+S
Sbjct: 234 GLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSS 268
Score = 38.1 bits (87), Expect = 0.063
Identities = 38/154 (24%), Positives = 64/154 (41%), Gaps = 18/154 (11%)
Query: 737 TEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGR--VKLTVNLDCIRINCNSSK 793
T A+ +++ F + + +L+ S D L L + G+ VK V D I I +++
Sbjct: 112 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 171
Query: 794 GPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIIT 853
+ND ++H VR R G + L VD + AG +L N + II
Sbjct: 172 ----------INDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIII 219
Query: 854 ERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 887
+ F G L L +NG+ +++ D
Sbjct: 220 GGK---EQGQPFQGQLSGLYYNGLKVLNMAAEND 250
Score = 32.0 bits (71), Expect = 4.5
Identities = 19/81 (23%), Positives = 41/81 (50%), Gaps = 2/81 (2%)
Query: 539 DFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT--LRT 596
D+ + + G + + ++G+ I I+ +NDG+++ V F R G + T+ V++ +
Sbjct: 141 DYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 200
Query: 597 PYTAPGESEILDLDDELYLGG 617
Y A + I + + +GG
Sbjct: 201 RYPAGRQLTIFNSQATIIIGG 221
>gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens]
Length = 432
Score = 488 bits (1257), Expect = e-137
Identities = 251/355 (70%), Positives = 290/355 (81%), Gaps = 6/355 (1%)
Query: 1123 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1182
G TYIF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1183 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQ 1242
QGKIGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP GRQ
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 203
Query: 1243 LTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS 1302
LTIFN+QA I IGGK++G+ FQGQLSGLYY+GLKVLNMAAEN+ NI I G+VRLVGEVPS
Sbjct: 204 LTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPS 263
Query: 1303 SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDD 1362
+ T T T+M EMST++METTTT+AT+T R+ + Q T D LV+SAEC SDD
Sbjct: 264 ILGTTQT-TSMPPEMSTTVMETTTTMATTTTRKNRSTAS---IQPTSDDLVSSAECSSDD 319
Query: 1363 EDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM 1422
ED CEPS+G ANPT G R PG++EVIRESSSTTGMVVGIVAAAALCILILLYAM
Sbjct: 320 EDFVECEPSTGRSANPTEPGIRR-VPGASEVIRESSSTTGMVVGIVAAAALCILILLYAM 378
Query: 1423 YKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
YKYRNRDEGSY VDE+RNYISNSAQSNG ++KEKQ SS KS +K +KNKD+EYYV
Sbjct: 379 YKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 432
Score = 38.9 bits (89), Expect = 0.037
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 4/88 (4%)
Query: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 124 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 182
Query: 124 RNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
N TL +D E R +T+F+
Sbjct: 183 GNATLQVDNWPVN--EHYPTGRQLTIFN 208
Score = 37.7 bits (86), Expect = 0.083
Identities = 43/206 (20%), Positives = 86/206 (41%), Gaps = 35/206 (16%)
Query: 434 FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPIT-FETPESFIS 492
F GC+ V+ +++V S + G H K +V PI+ + +P S
Sbjct: 25 FWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSV----PISIYRSPVSL-- 78
Query: 493 LPKWNAKKTGSISFDFRTTEPNGLILFS---HGKPRHQKD---------AKHPQMIKVD- 539
+ G + + GLIL++ + +P + D K ++++D
Sbjct: 79 -------RGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDS 131
Query: 540 ------FFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT 593
F + + G + ++ ++G+ I IK VNDG+++ V F R+G + T+ V+
Sbjct: 132 APGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
Query: 594 --LRTPYTAPGESEILDLDDELYLGG 617
+ Y + I + ++ +GG
Sbjct: 192 WPVNEHYPTGRQLTIFNTQAQIAIGG 217
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 737 TEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSSKGP 795
T ++ +++ F + GIL+ S D L+L ++ G++ + N+ + I+ + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 796 ETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 827
+ND ++H VR R G + L VD+
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 37.0 bits (84), Expect = 0.14
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 7/106 (6%)
Query: 933 FKTTSLDGLIL-YNSGDG-NDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHN 990
F TT DG+++ +S G DF+ + + +G + VF++G IK P+ND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 991 VMISRDTSNLHTVKIDTKITTQITAGARNLDL---KSDLYIGGVAK 1033
V +R+ N T+++D + R L + ++ + IGG K
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK 220
>gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens]
Length = 459
Score = 466 bits (1200), Expect = e-131
Identities = 250/385 (64%), Positives = 289/385 (75%), Gaps = 39/385 (10%)
Query: 1123 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1182
G TYIF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1183 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-- 1240
QGKIGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP G
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNT 203
Query: 1241 ----------------------------RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 1272
RQLTIFN+QA I IGGK++G+ FQGQLSGLYY
Sbjct: 204 DNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 263
Query: 1273 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATST 1332
+GLKVLNMAAEN+ NI I G+VRLVGEVPS + T T T+M EMST++METTTT+AT+T
Sbjct: 264 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT-TSMPPEMSTTVMETTTTMATTT 322
Query: 1333 ARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAE 1392
R+ + Q T D LV+SAEC SDDED CEPS+ ANPT G R PG++E
Sbjct: 323 TRKNRSTAS---IQPTSDDLVSSAECSSDDEDFVECEPST---ANPTEPGIRR-VPGASE 375
Query: 1393 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAV 1452
VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY VDE+RNYISNSAQSNG +
Sbjct: 376 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTL 435
Query: 1453 VKEKQPSSAKSSNKNKKNKDKEYYV 1477
+KEKQ SS KS +K +KNKD+EYYV
Sbjct: 436 MKEKQQSS-KSGHKKQKNKDREYYV 459
Score = 38.5 bits (88), Expect = 0.048
Identities = 24/68 (35%), Positives = 38/68 (55%), Gaps = 2/68 (2%)
Query: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 124 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 182
Query: 124 RNTTLFID 131
N TL +D
Sbjct: 183 GNATLQVD 190
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 737 TEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSSKGP 795
T ++ +++ F + GIL+ S D L+L ++ G++ + N+ + I+ + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 796 ETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 827
+ND ++H VR R G + L VD+
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 36.2 bits (82), Expect = 0.24
Identities = 39/179 (21%), Positives = 76/179 (42%), Gaps = 33/179 (18%)
Query: 434 FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPIT-FETPESFIS 492
F GC+ V+ +++V S + G H K +V PI+ + +P S
Sbjct: 25 FWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSV----PISIYRSPVSL-- 78
Query: 493 LPKWNAKKTGSISFDFRTTEPNGLILFS---HGKPRHQKD---------AKHPQMIKVD- 539
+ G + + GLIL++ + +P + D K ++++D
Sbjct: 79 -------RGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDS 131
Query: 540 ------FFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVN 592
F + + G + ++ ++G+ I IK VNDG+++ V F R+G + T+ V+
Sbjct: 132 APGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVD 190
Score = 35.8 bits (81), Expect = 0.31
Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 933 FKTTSLDGLIL-YNSGDG-NDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHN 990
F TT DG+++ +S G DF+ + + +G + VF++G IK P+ND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 991 VMISRDTSNLHTVKID 1006
V +R+ N T+++D
Sbjct: 176 VRFTRNGGNA-TLQVD 190
>gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]
Length = 666
Score = 366 bits (940), Expect = e-101
Identities = 186/284 (65%), Positives = 221/284 (77%), Gaps = 32/284 (11%)
Query: 1123 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1182
GTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVRVDS+SGLGDYL+LHI
Sbjct: 90 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 149
Query: 1183 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPA--- 1239
QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQVDSWPV ERYPA
Sbjct: 150 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 209
Query: 1240 ---------------------------GRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 1272
GRQLTIFNSQA I IGG++QG+PFQGQ+SGLYY
Sbjct: 210 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 269
Query: 1273 NGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTTTLATS 1331
NGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTTT+AT+
Sbjct: 270 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 329
Query: 1332 TARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1374
T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 330 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 373
Score = 164 bits (416), Expect = 4e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1376 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1435
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 566 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 624
Query: 1436 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 625 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 666
Score = 37.7 bits (86), Expect = 0.083
Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 6/93 (6%)
Query: 287 KGSEYFCYDLSQNPIQSSS-DEITLSFKTLQRNGLMLHTGKSA---DYVNLALKNGAVSL 342
KG Y N S+ D + + F T QR+ +++ ++ DY+ L + G V +
Sbjct: 97 KGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGV 156
Query: 343 VINLGSGAFEALVEPVNGKFNDNAWHDVKVTRN 375
+ N+G+ + ++ N +D +H V+ TR+
Sbjct: 157 IFNVGTD--DITIDEPNAIVSDGKYHVVRFTRS 187
>gi|47519929 cell recognition molecule CASPR3 [Homo sapiens]
Length = 1288
Score = 219 bits (559), Expect = 1e-56
Identities = 256/1056 (24%), Positives = 441/1056 (41%), Gaps = 177/1056 (16%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 341
+ F G Y L + P++ D I+L FK +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 342 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
+N G+ + + PV +D WH V + + V +VD T
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIE--------LLDTQVNFTVDKH-TH 293
Query: 398 TGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVS---NNFMGCLKEVVYKNNDVRLELSR 454
+ D + L + GG P+ PG + +F GCL+ + Y DV +
Sbjct: 294 HFQAKGDSSYLDLNFEISFGGIPT----PGRSRAFRRKSFHGCLENLYYNGVDV----TE 345
Query: 455 LAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPN 514
LAK+ P++ + G V+F C T+ P+TF + S+++LP + + S++F FRT
Sbjct: 346 LAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRA 404
Query: 515 GLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGE 574
G +LF G+ R + F + + DG L L L + + +NDG+
Sbjct: 405 GHLLF--GELRRGSGS----------FVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQ 452
Query: 575 WYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTA 634
W+ V F + V+ P + ++D D Y GG +N +G + +
Sbjct: 453 WHSVSFSAKWSHMNVVVDD--DTAVQPLVAVLIDSGDTYYFGGCLDNSSGSGCKSPLG-- 508
Query: 635 LLNYGYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 692
G+ GC+R + I ++ D + Q + S ++ T + CL + C++ G C
Sbjct: 509 ----GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CLPSYCEHGGECS 563
Query: 693 DGWNRYVCDCSGTGYLG---------RSCEREAT--------VLSYDGS----------- 724
W+ + CDC GTGY G +SCE + DGS
Sbjct: 564 QSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSGPLGPFLVYCN 623
Query: 725 MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNL-- 782
M VV H + V+LR + SA + AG+++ VNL
Sbjct: 624 MTADAAWTVVQHGGPDAVTLRGAP---------SGHPRSAVSFAYAAGAGQLRSAVNLAE 674
Query: 783 ---DCIRINCNSSKGPE----TLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQM 835
+ + C +++ P+ T + + NE HT S ++ D Q T +
Sbjct: 675 RCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHT--------SWGGSLPDAQKCTCGL 726
Query: 836 AGDHTRLEFH-NIETG---------IITERRYL--SSVPSNFIGHLQSLTFNGMAYIDLC 883
G+ +++ N + G +++++ +L + + G S + + LC
Sbjct: 727 EGNCIDSQYYCNCDAGRNEWTSDTIVLSQKEHLPVTQIVMTDAGRPHSEAAYTLGPL-LC 785
Query: 884 KNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLIL 943
+ GD + + +F T++SY+ + + F FKTT G+ +
Sbjct: 786 R-GDQSFW-------------NSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFM 831
Query: 944 YNSGDGNDFIVVEL-VKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNL 1000
N G DFI +EL + + FD+GNG + S P NDNQWH+V R+ ++L
Sbjct: 832 ENLGI-TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASL 890
Query: 1001 HTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNG 1060
++ K+ G L L S L+IGG A + GF GC+ S+ LNG
Sbjct: 891 QVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATR-----------QRGFLGCIRSLQLNG 939
Query: 1061 RLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
DL A G +E GC G +T C N G C ++ G +CDC+ +++ GP C+
Sbjct: 940 VALDLEERATVTPG-VEPGCAGHCST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCS 997
Query: 1121 DPGTTYIFSKGGGQITYKWPPN----------------DRPSTRADRLAIGFSTVQKEAV 1164
+ + Y + G +TY + + D TR + + + F T + ++
Sbjct: 998 NEISAYFAT--GSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSL 1054
Query: 1165 LVRVDSSSGLGDYLELHI-HQGKIGVKFNV----GTDDIAIEESNAIINDGKYHVVRFTR 1219
L+ V SS +YL + + + G + +++ + D + N + DG+ H V+ R
Sbjct: 1055 LLYV--SSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINR 1110
Query: 1220 SGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIG 1255
A + V+ ++ T FN+ ++I+G
Sbjct: 1111 E--EAVVMVEVNQSTKKQVILSSGTEFNAVKSLILG 1144
Score = 118 bits (296), Expect = 4e-26
Identities = 116/419 (27%), Positives = 182/419 (43%), Gaps = 21/419 (5%)
Query: 712 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 770
C ++ V+ +DG + +L DV SL+F++ ++ GIL+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
L G++ +N ++ S+ P TL G L+D WH+V + + TVD +
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVD-KHT 292
Query: 831 MTGQMAGDHTRLEFHNIET---GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 887
Q GD + L+ N E GI T R + +F G L++L +NG+ +L K
Sbjct: 293 HHFQAKGDSSYLDL-NFEISFGGIPTPGRSRAFRRKSFHGCLENLYYNGVDVTELAKKHK 351
Query: 888 IDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 946
+ N F PVTF + SY+AL + + FQF+T + G +L+
Sbjct: 352 PQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411
Query: 947 -GDGNDFIVVELVKGYLHY-VFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1004
G+ V+ L G L +F G + + LND QWH+V S S+++ V
Sbjct: 412 LRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVV 469
Query: 1005 IDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPD 1064
D + A +D Y GG + S K GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL--IDSGDTYYFGGCLDNSSGSGCK--SPLGGFQGCLRLITIGDKAVD 525
Query: 1065 LI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
I AL ++ G + C C + G C Q WD FSCDC T ++G C+
Sbjct: 526 PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 73.6 bits (179), Expect = 1e-12
Identities = 73/305 (23%), Positives = 126/305 (41%), Gaps = 36/305 (11%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 800 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 857
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGLF 154
T+ + TP ND WH VR R + +L +DQ+ K + + + S LF
Sbjct: 858 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLF 917
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
+GG + R+R F G IR +++N + L++ + G
Sbjct: 918 IGG--------------TATRQR-GFLGCIRSLQLNGV--------ALDLEERATVTPGV 954
Query: 215 SPCEAGE-EGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQ 273
P AG G +C NGG C CDC+ + + G CS E + A+ G
Sbjct: 955 EPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEIS-----AYFATGSS 1009
Query: 274 GKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-SADYVN 332
+E Y T + + + + ITLSF+T + L+L+ +Y++
Sbjct: 1010 MTYHFQEHY--TLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLS 1067
Query: 333 LALKN 337
+ L N
Sbjct: 1068 VILAN 1072
Score = 46.6 bits (109), Expect = 2e-04
Identities = 49/213 (23%), Positives = 85/213 (39%), Gaps = 34/213 (15%)
Query: 54 MSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDG 112
++FQ +T + G +L+ + G F+ + + G+L+LS P + A +NDG
Sbjct: 394 VTFQFRTWNRAGHLLFGELRRGSGSFV--LFLKDGKLKLSLFQPGQSPRNVTAGAGLNDG 451
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALKLT 170
WHSV ++ + + +D A V + + SG + GG + K
Sbjct: 452 QWHSVSFSAKWSHMNVVVDDDTAVQPLVA-----VLIDSGDTYYFGGCLDNSSGSGCKSP 506
Query: 171 LASVREREPFKGWIRDVRVNSSQVLPV--------DSGEVKLDDEPPNSGGGSPCEAGEE 222
L F+G +R + + V P+ ++++D C +
Sbjct: 507 LGG------FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDS----------CGITDR 550
Query: 223 GEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
C +GG CS D CDC TG+ G+ C
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 43.1 bits (100), Expect = 0.002
Identities = 58/271 (21%), Positives = 102/271 (37%), Gaps = 48/271 (17%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCS--RTGFRGKDCSQEDNNVE 263
+E S GGS +A + C G + +D Q C+C R +
Sbjct: 706 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDAGRNEWTSDTIVLSQKEHL 759
Query: 264 GLAHLMMGDQGKSKGKEEYIA---------TFKGSEYFCYDLSQNPIQSSSDEITLS--- 311
+ ++M D G+ + Y +F S F + S + E+T
Sbjct: 760 PVTQIVMTDAGRPHSEAAYTLGPLLCRGDQSFWNSASFNTETSYLHFPAFHGELTADVCF 819
Query: 312 -FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKFNDNAWHD 369
FKT +G+ + D++ + L+ V+ ++G+G E V+ FNDN WH
Sbjct: 820 FFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFNDNQWHH 878
Query: 370 VKVTRNLR----QHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
V+ RN++ Q + M DG + L + ++GG+ +
Sbjct: 879 VRAERNVKGASLQVDQLPQKMQPAPADG-----------HVRLQLNSQLFIGGTATR--- 924
Query: 426 PGSPVSNNFMGCLKEVVYKNNDVRLELSRLA 456
F+GC++ + + N V L+L A
Sbjct: 925 -----QRGFLGCIRSL--QLNGVALDLEERA 948
Score = 35.4 bits (80), Expect = 0.41
Identities = 37/183 (20%), Positives = 72/183 (39%), Gaps = 20/183 (10%)
Query: 1150 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES------ 1203
D +++ F +Q +L+ + G +++ L + +GK+ N G + +
Sbjct: 206 DVISLKFKAMQSNGILLHREGQHG--NHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTL 263
Query: 1204 NAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKE----- 1258
++++D +H V VD + A + + I GG
Sbjct: 264 GSLLDDQHWHSVLIELLDTQVNFTVDKHT--HHFQAKGDSSYLDLNFEISFGGIPTPGRS 321
Query: 1259 ---QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQS 1315
+ + F G L LYYNG+ V +A ++ I ++GNV P T T + +S
Sbjct: 322 RAFRRKSFHGCLENLYYNGVDVTELAKKHKPQILMMGNVSF--SCPQPQTVPVTFLSSRS 379
Query: 1316 EMS 1318
++
Sbjct: 380 YLA 382
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 216 bits (549), Expect = 2e-55
Identities = 255/1063 (23%), Positives = 437/1063 (41%), Gaps = 191/1063 (17%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 341
+ F G Y L + P++ D I+L FK +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 342 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
+N G+ + + PV +D WH V + +D
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIEL----------------LD----- 281
Query: 398 TGYTQEDYTMLGSDDFFYVGGSPSTADL-----------PGSP---VSNNFMGCLKEVVY 443
TQ ++T+ F G S DL PG +F GCL+ + Y
Sbjct: 282 ---TQVNFTVDKHTHHFQAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYY 338
Query: 444 KNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGS 503
DV + LAK+ P++ + G V+F C T+ P+TF + S+++LP + + S
Sbjct: 339 NGVDV----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVS 393
Query: 504 ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKI 563
++F FRT G +LF G+ + + F + + DG L L L + +
Sbjct: 394 VTFQFRTWNRAGHLLF--GELQRGSGS----------FVLFLKDGKLKLSLFQAGQSPRN 441
Query: 564 KALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKA 623
+NDG+W+ V F + V+ P + ++D D Y GG N +
Sbjct: 442 VTAGAGLNDGQWHSVSFSAKWSHMNVVVDD--DTAVQPLVAVLIDSGDTYYFGGCLGNSS 499
Query: 624 GLVFPTEVWTALLNYGYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCL 681
G + + G+ GC+R + I ++ D + Q + S ++ T + CL
Sbjct: 500 GSGCKSPLG------GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CL 552
Query: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLG---------RSCEREAT--------VLSYDGS 724
+ C++ G C W+ + CDC GTGY G +SCE + DGS
Sbjct: 553 PSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGS 612
Query: 725 -----------MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDA 773
M VV H + V+LR + + + SA + A
Sbjct: 613 GPLGPFLVYCNMTADSAWTVVRHGGPDAVTLR-GAPSGHPL--------SAVSFAYAAGA 663
Query: 774 GRVKLTVNL-----DCIRINCNSSKGPE----TLFAGYNLNDNEWHTVRVVRRGKSLKLT 824
G+++ VNL + + C +++ P+ T + + NE HT S +
Sbjct: 664 GQLRAAVNLAERCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHT--------SWGGS 715
Query: 825 VDDQQAMTGQMAGDHTRLEFH-NIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLC 883
+ D Q T + G+ +++ N + G + + S + + + L + D
Sbjct: 716 LPDAQKCTCGLEGNCIDSQYYCNCDAG---QNEWTSD--TIVLSQKEHLPVTQIVMTDTG 770
Query: 884 K-NGDIDY------CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTT 936
+ + + DY C + F + +F T++SY+ + + F FKTT
Sbjct: 771 QPHSEADYTLGPLLCRGDKSFW------NSASFNTETSYLHFPAFHGELTADVCFFFKTT 824
Query: 937 SLDGLILYNSGDGNDFIVVEL-VKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISR 995
G+ + N G DFI +EL + + FD+GNG + S P NDNQWH+V R
Sbjct: 825 VSSGVFMENLGI-TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAER 883
Query: 996 DT--SNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCL 1053
+ ++L ++ K+ G L L S L+IGG A + GF GC+
Sbjct: 884 NVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATR-----------QRGFLGCI 932
Query: 1054 ASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTS 1113
S+ LNG DL A G +E GC G +T C N G C ++ G +CDC+ ++
Sbjct: 933 RSLQLNGVALDLEERATVTPG-VEPGCAGHCST-YGHLCRNGGRCREKRRGVTCDCAFSA 990
Query: 1114 FSGPLCNDPGTTYIFSKGGGQITYKWPPN----------------DRPSTRADRLAIGFS 1157
+ GP C++ + Y + G +TY + + D TR + + + F
Sbjct: 991 YDGPFCSNEISAYFAT--GSSMTYHFQEHYTLSENSSSLVSSLYRDVTLTR-EMITLSFR 1047
Query: 1158 TVQKEAVLVRVDSSSGLGDYLELHI-HQGKIGVKFNV----GTDDIAIEESNAIINDGKY 1212
T + ++L+ V SS +YL + + + G + +++ + D + N + DG+
Sbjct: 1048 TTRSPSLLLYV--SSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKN--MADGQL 1103
Query: 1213 HVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIG 1255
H V+ R A + V+ ++ T FN+ ++I+G
Sbjct: 1104 HQVKINRE--EAVVMVEVNQSAKKQVILSSGTEFNAVKSLILG 1144
Score = 120 bits (301), Expect = 1e-26
Identities = 115/419 (27%), Positives = 182/419 (43%), Gaps = 21/419 (5%)
Query: 712 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 770
C ++ V+ +DG + L DV SL+F++ ++ GIL+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
L G++ +N ++ S+ P TL G L+D WH+V + + TVD +
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVD-KHT 292
Query: 831 MTGQMAGDHTRLEFHNIET---GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 887
Q GD + L+ N E GI++ R + +F G L++L +NG+ +L K
Sbjct: 293 HHFQAKGDSSNLDL-NFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHK 351
Query: 888 IDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 946
+ N F PVTF + SY+AL + + FQF+T + G +L+
Sbjct: 352 PQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411
Query: 947 GD-GNDFIVVELVKGYLHY-VFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1004
G+ V+ L G L +F G + + LND QWH+V S S+++ V
Sbjct: 412 LQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVV 469
Query: 1005 IDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPD 1064
D + A +D Y GG + S K GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL--IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVD 525
Query: 1065 LI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
I AL ++ G + C C + G C Q WD FSCDC T ++G C+
Sbjct: 526 PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 73.2 bits (178), Expect = 2e-12
Identities = 73/305 (23%), Positives = 126/305 (41%), Gaps = 36/305 (11%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 800 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 857
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGLF 154
T+ + TP ND WH VR R + +L +DQ+ K + + + S LF
Sbjct: 858 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLF 917
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
+GG + R+R F G IR +++N + L++ + G
Sbjct: 918 IGG--------------TATRQR-GFLGCIRSLQLNGV--------ALDLEERATVTPGV 954
Query: 215 SPCEAGE-EGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQ 273
P AG G +C NGG C CDC+ + + G CS E + A+ G
Sbjct: 955 EPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEIS-----AYFATGSS 1009
Query: 274 GKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-SADYVN 332
+E Y T + + + + ITLSF+T + L+L+ +Y++
Sbjct: 1010 MTYHFQEHY--TLSENSSSLVSSLYRDVTLTREMITLSFRTTRSPSLLLYVSSFYEEYLS 1067
Query: 333 LALKN 337
+ L N
Sbjct: 1068 VILAN 1072
Score = 47.8 bits (112), Expect = 8e-05
Identities = 49/213 (23%), Positives = 85/213 (39%), Gaps = 34/213 (15%)
Query: 54 MSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDG 112
++FQ +T + G +L+ + G F+ + + G+L+LS P + A +NDG
Sbjct: 394 VTFQFRTWNRAGHLLFGELQRGSGSFV--LFLKDGKLKLSLFQAGQSPRNVTAGAGLNDG 451
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALKLT 170
WHSV ++ + + +D A V + + SG + GG + K
Sbjct: 452 QWHSVSFSAKWSHMNVVVDDDTAVQPLVA-----VLIDSGDTYYFGGCLGNSSGSGCKSP 506
Query: 171 LASVREREPFKGWIRDVRVNSSQVLPV--------DSGEVKLDDEPPNSGGGSPCEAGEE 222
L F+G +R + + V P+ ++++D C +
Sbjct: 507 LGG------FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDS----------CGITDR 550
Query: 223 GEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
C +GG CS D CDC TG+ G+ C
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 42.4 bits (98), Expect = 0.003
Identities = 60/275 (21%), Positives = 106/275 (38%), Gaps = 56/275 (20%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEG- 264
+E S GGS +A + C G + +D Q C+C G++ D V
Sbjct: 706 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDA----GQNEWTSDTIVLSQ 755
Query: 265 -----LAHLMMGDQGKSKGKEEYIA---------TFKGSEYFCYDLSQNPIQSSSDEITL 310
+ ++M D G+ + +Y +F S F + S + E+T
Sbjct: 756 KEHLPVTQIVMTDTGQPHSEADYTLGPLLCRGDKSFWNSASFNTETSYLHFPAFHGELTA 815
Query: 311 S----FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKFNDN 365
FKT +G+ + D++ + L+ V+ ++G+G E V+ FNDN
Sbjct: 816 DVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFNDN 874
Query: 366 AWHDVKVTRNLR----QHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPS 421
WH V+ RN++ Q + M DG + L + ++GG+ +
Sbjct: 875 QWHHVRAERNVKGASLQVDQLPQKMQPAPADG-----------HVRLQLNSQLFIGGTAT 923
Query: 422 TADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLA 456
F+GC++ + + N V L+L A
Sbjct: 924 R--------QRGFLGCIRSL--QLNGVALDLEERA 948
Score = 34.7 bits (78), Expect = 0.70
Identities = 37/181 (20%), Positives = 73/181 (40%), Gaps = 16/181 (8%)
Query: 1150 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES------ 1203
D +++ F +Q +L+ + G +++ L + +GK+ N G + +
Sbjct: 206 DVISLKFKAMQSNGILLHREGQHG--NHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTL 263
Query: 1204 NAIINDGKYHVVRFTRSGGNATLQVDSWP---VIERYPAGRQLTIFNSQATIIIGGKEQG 1260
++++D +H V VD + + L S I+ G+ +
Sbjct: 264 GSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQAKGDSSNLDLNFEISFGGILSPGRSRA 323
Query: 1261 ---QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEM 1317
+ F G L LYYNG+ V +A ++ I ++GNV P T T + +S +
Sbjct: 324 FTRKSFHGCLENLYYNGVDVTELAKKHKPQILMMGNVSF--SCPQPQTVPVTFLSSRSYL 381
Query: 1318 S 1318
+
Sbjct: 382 A 382
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 166 bits (421), Expect = 1e-40
Identities = 159/602 (26%), Positives = 257/602 (42%), Gaps = 116/602 (19%)
Query: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGY-LHYVF 966
+F SSY+ +T Q TS + F FKT + G+ L N G DFI +EL + + F
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGK-EDFIKLELKSATEVSFSF 860
Query: 967 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1024
D+GNG I S PLND+QWH V R+ ++L ++ +I T G L+L S
Sbjct: 861 DVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYS 920
Query: 1025 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1084
L++GG ++GF GC+ S+ +NG DL A +G I GC G
Sbjct: 921 QLFVGGAG------------GQQGFLGCIRSLRMNGVTLDLEERAKVTSGFIS-GCSGHC 967
Query: 1085 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN-DPGTTYIFSKGGGQITYKW---- 1139
T+ +C N G CL+++ G+SCDCS T++ G CN D G F + G + Y +
Sbjct: 968 TS-YGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA---FFEEGMWLRYNFQAPA 1023
Query: 1140 ---------------PPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIH- 1183
N P + + FST + +L+ + SS D+L + +
Sbjct: 1024 TNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYI--SSFTTDFLAVLVKP 1081
Query: 1184 QGKIGVKFNVG--TDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGR 1241
G + +++N+G + I+ + + +G+ H V TR L++D +P + +
Sbjct: 1082 TGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSS 1141
Query: 1242 QLTIFNSQATIIIG------------GKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIA 1289
T+FNS ++ +G K F G LS + +N + L AA N +
Sbjct: 1142 SDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLK-AALRQTNAS 1200
Query: 1290 IVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTD 1349
+V + GE+ ES A P T P+S TD
Sbjct: 1201 --AHVHIQGEL-----VESNCGA------------------------SPLTLSPMSSATD 1229
Query: 1350 DILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPY-PGSAEVIRESSSTTGMVV-GI 1407
P + +D A PY PG + IR + ++ G+
Sbjct: 1230 ---------PWHLDHLD-------------SASADFPYNPGQGQAIRNGVNRNSAIIGGV 1267
Query: 1408 VAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKN 1467
+A IL L + +Y R +G+YH +E++ + SA+S A + P+ ++ +++
Sbjct: 1268 IAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKG--AESAESADAAIMNNDPNFTETIDES 1325
Query: 1468 KK 1469
KK
Sbjct: 1326 KK 1327
Score = 115 bits (289), Expect = 2e-25
Identities = 105/437 (24%), Positives = 197/437 (45%), Gaps = 25/437 (5%)
Query: 701 DCSGTGYLGR-----SCEREATVLSYDGSMFMKIQLP-VVMHTEAEDVSLRFRSQRAYGI 754
D +G G +G C A V+++DG + + + M T + ++L F++ + G+
Sbjct: 165 DWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGV 224
Query: 755 LMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRV 814
++ + D + LEL ++ L++NL ++ G ++ G L+D+ WH+V +
Sbjct: 225 ILHGEGQQG-DYITLELKKAKLVLSLNLGSNQLG--PIYGHTSVMTGSLLDDHHWHSVVI 281
Query: 815 VRRGKSLKLTVD-DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLT 873
R+G+S+ LT+D Q D+ L++ GI + SS NF G ++S+
Sbjct: 282 ERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESIN 341
Query: 874 FNGMAYIDLCKNGDIDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQ 932
+NG+ DL + ++ + N F PV F +SY+ + + FQ
Sbjct: 342 YNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNA-TSYLEVPGRLNQDLFSVSFQ 400
Query: 933 FKTTSLDGLILYNS-GDGNDFIVVELVKGYLHYVFDLGNGA-NLIKGSSNKPLNDNQWHN 990
F+T + +GL++++ D + ++L + + ++ + I SS LND QWH
Sbjct: 401 FRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE 460
Query: 991 V-MISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGF 1049
V ++++ + T+ D + T + + GG + S ++ + F
Sbjct: 461 VRFLAKENFAILTIDGDEASAVR-TNSPLQVKTGEKYFFGGFLNQMNNSSHSVL--QPSF 517
Query: 1050 QGCLASVDLNGRLPDLISDAL-----FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDG 1104
QGC+ + ++ +L +L A F N I+ C C + C + G C Q WD
Sbjct: 518 QGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDM-C-AIIDRCVPNHCEHGGKCSQTWDS 575
Query: 1105 FSCDCSMTSFSGPLCND 1121
F C C T +SG C++
Sbjct: 576 FKCTCDETGYSGATCHN 592
Score = 114 bits (284), Expect = 9e-25
Identities = 102/442 (23%), Positives = 183/442 (41%), Gaps = 50/442 (11%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-TGKSADYVNLALKNGAVS 341
+ F G Y +++ D I L+FKT + G++LH G+ DY+ L LK +
Sbjct: 187 VINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLV 246
Query: 342 LVINLGS---GAFEALVEPVNGKF-NDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
L +NLGS G + G +D+ WH V + R R + +++D +
Sbjct: 247 LSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRS--------INLTLDRSMQH 298
Query: 398 TGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 457
T ++ L D GG P + P S NF GC++ + Y + ++ LA+
Sbjct: 299 FR-TNGEFDYLDLDYEITFGGIPFSGK-PSSSSRKNFKGCMESINYNG----VNITDLAR 352
Query: 458 QGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLI 517
+ + G ++F C T+ P+ F S++ +P + S+SF FRT PNGL+
Sbjct: 353 RKKLEPSNVGNLSFSCVEPYTV-PVFFNAT-SYLEVPGRLNQDLFSVSFQFRTWNPNGLL 410
Query: 518 LFSHGKPR------HQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN 571
+FSH ++K I + + +D + GSG +N
Sbjct: 411 VFSHFADNLGNVEIDLTESKVGVHINITQTKMSQID------ISSGSG----------LN 454
Query: 572 DGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEV 631
DG+W+ V F ++++ + ++ + GG
Sbjct: 455 DGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSH---- 510
Query: 632 WTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSK-ETAKPCLSNPCKNNGM 690
++L + GC++ + +D Q ++ ++A+ + + S C+ N C++ G
Sbjct: 511 --SVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGK 568
Query: 691 CRDGWNRYVCDCSGTGYLGRSC 712
C W+ + C C TGY G +C
Sbjct: 569 CSQTWDSFKCTCDETGYSGATC 590
Score = 97.1 bits (240), Expect = 1e-19
Identities = 112/465 (24%), Positives = 193/465 (41%), Gaps = 73/465 (15%)
Query: 483 TFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFA 542
+F P S++ + + + ISF F+T P G+ L + GK DF
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKE--------------DFIK 847
Query: 543 IEMLDG-HLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTISVNTLRTPYT- 599
+E+ + D+G+G ++I +ND +W+ V +R+ + ++ V+ L
Sbjct: 848 LELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRK 907
Query: 600 APGESEI-LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQ 658
AP E L+L +L++GG + G++GCIR L ++G + D+ +
Sbjct: 908 APTEGHTRLELYSQLFVGGAGGQQ----------------GFLGCIRSLRMNGVTLDLEE 951
Query: 659 MAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATV 718
A+V T+G CS C+N G C + ++ Y CDCS T Y G C ++
Sbjct: 952 RAKV--TSGFISGCSGHCTS--YGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA 1007
Query: 719 LSYDGS-MFMKIQLPVVMHTEAEDVSLRFRS----QRAYGILMATTSRDSADTLR----- 768
+G + Q P T A D S R + Q ++ L R S T +
Sbjct: 1008 FFEEGMWLRYNFQAPA---TNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCIL 1064
Query: 769 -------LELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY-NLNDNEWHTVRVVRRGKS 820
+ A VK T +L IR N ++ P + + N+ + + H+V + R K+
Sbjct: 1065 LYISSFTTDFLAVLVKPTGSLQ-IRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKT 1123
Query: 821 LKLTVDDQQAMTGQMAGDHTRLEFHN---------IETGIITERRYLSSVPSNFIGHLQS 871
+ L +D +++ + L F++ IETG I + + + P F G L
Sbjct: 1124 IFLKLDHYPSVSYHLPSSSDTL-FNSPKSLFLGKVIETGKIDQEIHKYNTP-GFTGCLSR 1181
Query: 872 LTFNGMAYID--LCKNGDIDYCELNARFGFRNIIADPVTFKTKSS 914
+ FN +A + L + + + N A P+T SS
Sbjct: 1182 VQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSS 1226
Score = 73.9 bits (180), Expect = 1e-12
Identities = 72/337 (21%), Positives = 136/337 (40%), Gaps = 79/337 (23%)
Query: 504 ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSG---- 559
I+ +F+T+E G+IL G+ + D+ +E+ L L L++GS
Sbjct: 212 IALNFKTSESEGVILHGEGQ-------------QGDYITLELKKAKLVLSLNLGSNQLGP 258
Query: 560 -----TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELY 614
++ +LL +D W+ V +R GRS ++++ + GE + LDLD E+
Sbjct: 259 IYGHTSVMTGSLL---DDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEIT 315
Query: 615 LGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSK 674
GG+P +G S S+
Sbjct: 316 FGGIP---------------------------------------------FSGKPSSSSR 330
Query: 675 ETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATV-LSYDGSMFMKIQLPV 733
+ K C+ + N D R + S G L SC TV + ++ + ++++ P
Sbjct: 331 KNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEV--PG 388
Query: 734 VMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSK 793
++ + VS +FR+ G+L+ + D+ + ++L +V + +N+ +
Sbjct: 389 RLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINI------TQTKM 442
Query: 794 GPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
+ +G LND +WH VR + + LT+D +A
Sbjct: 443 SQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEA 479
Score = 65.5 bits (158), Expect = 4e-10
Identities = 76/344 (22%), Positives = 141/344 (40%), Gaps = 40/344 (11%)
Query: 40 WTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE 99
+ F + +++SF KT + G+ L ++ G DF++L L + SF +
Sbjct: 809 YLHFSTFQGETSADISFYFKTLTPWGVFL--ENMGKEDFIKLELKSATEVSFSFDVGNGP 866
Query: 100 PATLL-ADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSK-RRDMTVFSGLFVGG 157
++ + TP+ND WH V R + +L +D++ + + ++ + ++S LFVGG
Sbjct: 867 VEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGG 926
Query: 158 LPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPC 217
++ F G IR +R+N + + +V SG S C
Sbjct: 927 ----------------AGGQQGFLGCIRSLRMNGVTLDLEERAKV-------TSGFISGC 963
Query: 218 EAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNV--EG--LAHLMMGDQ 273
G C NGG C CDCS T + G C+++ EG L +
Sbjct: 964 SGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPA 1023
Query: 274 GKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-SADYVN 332
++ + + DL+Q +EI SF T + ++L+ + D++
Sbjct: 1024 TNARDSSSRVDNAPDQQNSHPDLAQ-------EEIRFSFSTTKAPCILLYISSFTTDFLA 1076
Query: 333 LALK-NGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRN 375
+ +K G++ + NLG ++ + + H V +TR+
Sbjct: 1077 VLVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRH 1120
Score = 61.6 bits (148), Expect = 5e-09
Identities = 77/306 (25%), Positives = 134/306 (43%), Gaps = 55/306 (17%)
Query: 933 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLG-NGANLIKGSSN----KPLNDNQ 987
FKT+ +G+IL+ G D+I +EL K L +LG N I G ++ L+D+
Sbjct: 216 FKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHH 275
Query: 988 WHNVMISRDTSNLHTVKIDTKITTQITAGARN-LDLKSDLYIGGVAKETYKSLPKLVHAK 1046
WH+V+I R +++ + +D + T G + LDL ++ GG+ + P ++
Sbjct: 276 WHSVVIERQGRSIN-LTLDRSMQHFRTNGEFDYLDLDYEITFGGIP---FSGKPSS-SSR 330
Query: 1047 EGFQGCLASVDLNG-RLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGF 1105
+ F+GC+ S++ NG + DL ++ SN G
Sbjct: 331 KNFKGCMESINYNGVNITDLARR-------------------KKLEPSNVG--------- 362
Query: 1106 SCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVL 1165
SFS C +P T +F +Y P R + ++ F T +L
Sbjct: 363 -----NLSFS---CVEPYTVPVFFNA---TSYLEVPG-RLNQDLFSVSFQFRTWNPNGLL 410
Query: 1166 VRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEE--SNAIINDGKYHVVRFTRSGGN 1223
V + LG+ +E+ + + K+GV N+ ++ + S + +NDG++H VRF
Sbjct: 411 VFSHFADNLGN-VEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENF 469
Query: 1224 ATLQVD 1229
A L +D
Sbjct: 470 AILTID 475
Score = 49.7 bits (117), Expect = 2e-05
Identities = 39/185 (21%), Positives = 81/185 (43%), Gaps = 18/185 (9%)
Query: 1142 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIA-- 1199
N + T D +A+ F T + E V++ + G DY+ L + + K+ + N+G++ +
Sbjct: 202 NKKMKTLKDVIALNFKTSESEGVILHGEGQQG--DYITLELKKAKLVLSLNLGSNQLGPI 259
Query: 1200 ----IEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIG 1255
+ ++++D +H V R G + L +D ++ + + + I G
Sbjct: 260 YGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDR--SMQHFRTNGEFDYLDLDYEITFG 317
Query: 1256 GKE-QGQP-------FQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTE 1307
G G+P F+G + + YNG+ + ++A + VGN+ P ++
Sbjct: 318 GIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVF 377
Query: 1308 STATA 1312
AT+
Sbjct: 378 FNATS 382
Score = 49.7 bits (117), Expect = 2e-05
Identities = 47/162 (29%), Positives = 74/162 (45%), Gaps = 34/162 (20%)
Query: 304 SSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKF 362
+S +I+ FKTL G+ L D++ L LK+ VS ++G+G E +V
Sbjct: 819 TSADISFYFKTLTPWGVFLENMGKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPT-PL 877
Query: 363 NDNAWHDVKVTRNLRQHSGIGHAMVTISVDGI------LTTTGYTQ-EDYTMLGSDDFFY 415
ND+ WH V RN++Q S + VD + T G+T+ E Y+ L +
Sbjct: 878 NDDQWHRVTAERNVKQAS--------LQVDRLPQQIRKAPTEGHTRLELYSQL------F 923
Query: 416 VGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 457
VGG+ F+GC++ + + N V L+L AK
Sbjct: 924 VGGAGG---------QQGFLGCIRSL--RMNGVTLDLEERAK 954
Score = 44.3 bits (103), Expect = 9e-04
Identities = 52/221 (23%), Positives = 88/221 (39%), Gaps = 18/221 (8%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGG-RLQLSFSIFCAEPATLLADTPVNDG 112
+SFQ +T + GL+++ +E+ LT + ++ + + + + +NDG
Sbjct: 397 VSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDG 456
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLA 172
WH VR + L ID EA V S + T F GG ++ ++ +
Sbjct: 457 QWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTG-EKYFFGGFLNQMNNSSHSVLQP 515
Query: 173 SVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG---SPCEAGEEGEGGVCL 229
S F+G ++ ++V+ V + + K P S C + C
Sbjct: 516 S------FQGCMQLIQVDDQLVNLYEVAQRK-----PGSFANVSIDMCAIIDRCVPNHCE 564
Query: 230 NGGVCSVVDDQAVCDCSRTGFRGKDC--SQEDNNVEGLAHL 268
+GG CS D C C TG+ G C S + + E HL
Sbjct: 565 HGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHL 605
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 164 bits (415), Expect = 6e-40
Identities = 190/805 (23%), Positives = 326/805 (40%), Gaps = 129/805 (16%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 341
+ F G Y L + P++ D I+L FK +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 342 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
+N G+ + + PV +D WH V + +D
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIEL----------------LD----- 281
Query: 398 TGYTQEDYTMLGSDDFFYVGGSPSTADL-----------PGSP---VSNNFMGCLKEVVY 443
TQ ++T+ F G S DL PG +F GCL+ + Y
Sbjct: 282 ---TQVNFTVDKHTHHFQAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYY 338
Query: 444 KNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGS 503
DV + LAK+ P++ + G V+F C T+ P+TF + S+++LP + + S
Sbjct: 339 NGVDV----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVS 393
Query: 504 ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKI 563
++F FRT G +LF G+ + + F + + DG L L L + +
Sbjct: 394 VTFQFRTWNRAGHLLF--GELQRGSGS----------FVLFLKDGKLKLSLFQAGQSPRN 441
Query: 564 KALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKA 623
+NDG+W+ V F + V+ P + ++D D Y GG N +
Sbjct: 442 VTAGAGLNDGQWHSVSFSAKWSHMNVVVDD--DTAVQPLVAVLIDSGDTYYFGGCLGNSS 499
Query: 624 GLVFPTEVWTALLNYGYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCL 681
G + + G+ GC+R + I ++ D + Q + S ++ T + CL
Sbjct: 500 GSGCKSPLG------GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CL 552
Query: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCERE-----------------ATVLSYDGS 724
+ C++ G C W+ + CDC GTGY G +C + DGS
Sbjct: 553 PSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGS 612
Query: 725 MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRD-SADTLRLELDAGRVKLTVNL- 782
+ L T++ +R A + A + SA + AG+++ VNL
Sbjct: 613 GPLGPFLVYCNMTDSAWTVVRHGGPDAVTLRGAPSGHPLSAVSFAYAAGAGQLRAAVNLA 672
Query: 783 ----DCIRINCNSSKGPE----TLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQ 834
+ + C +++ P+ T + + NE HT S ++ D Q T
Sbjct: 673 ERCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHT--------SWGGSLPDAQKCTCG 724
Query: 835 MAGDHTRLEFH-NIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCK-NGDIDY-- 890
+ G+ +++ N + G + + S + + + L + D + + + DY
Sbjct: 725 LEGNCIDSQYYCNCDAG---QNEWTSD--TIVLSQKEHLPVTQIVMTDTGQPHSEADYTL 779
Query: 891 ----CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 946
C + F + +F T++SY+ + + F FKTT G+ + N
Sbjct: 780 GPLLCRGDKSFW------NSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENL 833
Query: 947 GDGNDFIVVEL-VKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTV 1003
G DFI +EL + + FD+GNG + S P NDNQWH+V R+ ++L
Sbjct: 834 GI-TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 892
Query: 1004 KIDTKITTQITAGARNLDLKSDLYI 1028
++ K+ G L L S L+I
Sbjct: 893 QLPQKMQPAPADGHVRLQLNSQLFI 917
Score = 120 bits (301), Expect = 1e-26
Identities = 115/419 (27%), Positives = 182/419 (43%), Gaps = 21/419 (5%)
Query: 712 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 770
C ++ V+ +DG + L DV SL+F++ ++ GIL+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
L G++ +N ++ S+ P TL G L+D WH+V + + TVD +
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVD-KHT 292
Query: 831 MTGQMAGDHTRLEFHNIET---GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 887
Q GD + L+ N E GI++ R + +F G L++L +NG+ +L K
Sbjct: 293 HHFQAKGDSSNLDL-NFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHK 351
Query: 888 IDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 946
+ N F PVTF + SY+AL + + FQF+T + G +L+
Sbjct: 352 PQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411
Query: 947 GD-GNDFIVVELVKGYLHY-VFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1004
G+ V+ L G L +F G + + LND QWH+V S S+++ V
Sbjct: 412 LQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVV 469
Query: 1005 IDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPD 1064
D + A +D Y GG + S K GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL--IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVD 525
Query: 1065 LI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
I AL ++ G + C C + G C Q WD FSCDC T ++G C+
Sbjct: 526 PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 47.8 bits (112), Expect = 8e-05
Identities = 49/213 (23%), Positives = 85/213 (39%), Gaps = 34/213 (15%)
Query: 54 MSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDG 112
++FQ +T + G +L+ + G F+ + + G+L+LS P + A +NDG
Sbjct: 394 VTFQFRTWNRAGHLLFGELQRGSGSFV--LFLKDGKLKLSLFQAGQSPRNVTAGAGLNDG 451
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALKLT 170
WHSV ++ + + +D A V + + SG + GG + K
Sbjct: 452 QWHSVSFSAKWSHMNVVVDDDTAVQPLVA-----VLIDSGDTYYFGGCLGNSSGSGCKSP 506
Query: 171 LASVREREPFKGWIRDVRVNSSQVLPV--------DSGEVKLDDEPPNSGGGSPCEAGEE 222
L F+G +R + + V P+ ++++D C +
Sbjct: 507 LGG------FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDS----------CGITDR 550
Query: 223 GEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
C +GG CS D CDC TG+ G+ C
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 3/101 (2%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 799 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 856
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAK 136
T+ + TP ND WH VR R + +L +DQ+ K
Sbjct: 857 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQK 897
Score = 40.4 bits (93), Expect = 0.013
Identities = 45/192 (23%), Positives = 78/192 (40%), Gaps = 31/192 (16%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEG- 264
+E S GGS +A + C G + +D Q C+C G++ D V
Sbjct: 705 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDA----GQNEWTSDTIVLSQ 754
Query: 265 -----LAHLMMGDQGKSKGKEEYIA---------TFKGSEYFCYDLSQNPIQSSSDEITL 310
+ ++M D G+ + +Y +F S F + S + E+T
Sbjct: 755 KEHLPVTQIVMTDTGQPHSEADYTLGPLLCRGDKSFWNSASFNTETSYLHFPAFHGELTA 814
Query: 311 S----FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKFNDN 365
FKT +G+ + D++ + L+ V+ ++G+G E V+ FNDN
Sbjct: 815 DVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFNDN 873
Query: 366 AWHDVKVTRNLR 377
WH V+ RN++
Sbjct: 874 QWHHVRAERNVK 885
Score = 34.7 bits (78), Expect = 0.70
Identities = 37/181 (20%), Positives = 73/181 (40%), Gaps = 16/181 (8%)
Query: 1150 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES------ 1203
D +++ F +Q +L+ + G +++ L + +GK+ N G + +
Sbjct: 206 DVISLKFKAMQSNGILLHREGQHG--NHITLELIKGKLVFFLNSGNAKLPSTIAPVTLTL 263
Query: 1204 NAIINDGKYHVVRFTRSGGNATLQVDSWP---VIERYPAGRQLTIFNSQATIIIGGKEQG 1260
++++D +H V VD + + L S I+ G+ +
Sbjct: 264 GSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQAKGDSSNLDLNFEISFGGILSPGRSRA 323
Query: 1261 ---QPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEM 1317
+ F G L LYYNG+ V +A ++ I ++GNV P T T + +S +
Sbjct: 324 FTRKSFHGCLENLYYNGVDVTELAKKHKPQILMMGNVSF--SCPQPQTVPVTFLSSRSYL 381
Query: 1318 S 1318
+
Sbjct: 382 A 382
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 137 bits (346), Expect = 6e-32
Identities = 180/703 (25%), Positives = 287/703 (40%), Gaps = 118/703 (16%)
Query: 22 GCWAELGSGLEFPGAEGQ-WTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLE 80
G E G P EG+ + FP A ++ + + +GL+LY + DFL
Sbjct: 1363 GAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLA 1422
Query: 81 LILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEV 140
L L GR+QL F PA L + PV G WH + + R +R TL +D E
Sbjct: 1423 LALL-DGRVQLRFDTGSG-PAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGES 1480
Query: 141 KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV------ 194
S + + + LFVGG+P + A AL+ T +G IR + VN+ ++
Sbjct: 1481 PSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGA----GLRGCIRLLDVNNQRLELGIGP 1536
Query: 195 --LPVDSGEVKLDDEP--PN-SGGGSPCEAGEEG----------------------EGGV 227
SG + D P PN GG+PC+ E G +
Sbjct: 1537 GAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNP 1596
Query: 228 CLNGGVCSVV-DDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATF 286
C C V+ + A C+C G G C Q + +G + G S
Sbjct: 1597 CHGAAPCRVLPEGGAQCECP-LGREGTFC-QTASGQDGSGPFLADFNGFSH------LEL 1648
Query: 287 KGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSL 342
+G F DL + + + F +GL+L+ G+ D+V+LAL++ +
Sbjct: 1649 RGLHTFARDLGEKM------ALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEF 1702
Query: 343 VINLGSGAFEALV---EPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTG 399
+LG GA A++ EPV AW V + RN R+ + + V G
Sbjct: 1703 RYDLGKGA--AVIRSREPV----TLGAWTRVSLERNGRKGA--------LRVGDGPRVLG 1748
Query: 400 YTQEDYTMLGSDDFFYVGGSPSTADLP-GSPVSNNFMGCLKEV------VYKNNDVRLEL 452
+ +T+L + YVGG+P + L + VS+ F G ++ V + V ++
Sbjct: 1749 ESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQV 1808
Query: 453 SRLAKQGDPKMKIHGVVAFKCENVAT----------LDPITFETPESFISLPKWNAKKTG 502
+ G P + G C N A+ L P F P L + +A
Sbjct: 1809 DVTSFAGHPCTRASG---HPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVD 1865
Query: 503 SISFDFRT--------TEPNGLILFSHGKPRHQKDAKHPQMI-------KVDFFAIEMLD 547
+++FD RT TE + +H + + +A ++ + D+ A+ ++D
Sbjct: 1866 TLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVD 1925
Query: 548 GHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISV-NTLRTPYTAPGESEI 606
GHL L ++GS + +++ + VN W V R+ R G++ V N ++P +
Sbjct: 1926 GHLQLSYNLGSQPVVLRSTV-PVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQ 1984
Query: 607 LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFI 649
LD D L+LGGLPE G P T G+VGC+RD+ +
Sbjct: 1985 LDTDGALWLGGLPELPVGPALPKAYGT-----GFVGCLRDVVV 2022
Score = 117 bits (292), Expect = 1e-25
Identities = 170/711 (23%), Positives = 283/711 (39%), Gaps = 155/711 (21%)
Query: 473 CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKH 532
CE V FE SF++ P A T ++ +FR EP GL+L++ G R +
Sbjct: 1366 CEKVLGAPVPAFEG-RSFLAFPTLRAYHTLRLALEFRALEPQGLLLYN-GNARGK----- 1418
Query: 533 PQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVN 592
DF A+ +LDG + L D GSG + + + V G+W+ ++ R R GT+SV+
Sbjct: 1419 ------DFLALALLDGRVQLRFDTGSGPAVLTSAVP-VEPGQWHRLELSRHWRRGTLSVD 1471
Query: 593 TLRTPYT--APGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFID 650
TP +P ++ L+LD +L++GG+PE++A + + G GCIR L ++
Sbjct: 1472 G-ETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALER----TFVGAGLRGCIRLLDVN 1526
Query: 651 GQSKDIRQMAEVQSTAG--------------------------------------VKPSC 672
Q ++ + +T G V P+C
Sbjct: 1527 NQRLELG-IGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTC 1585
Query: 673 SKETAKPCLSNPCKNNGMCR---DGWNRYVCDCSGTGYLGRSCEREATVLSYDGS----- 724
+ E + PC NPC CR +G + C+C LGR T DGS
Sbjct: 1586 ADEKS-PCQPNPCHGAAPCRVLPEGGAQ--CECP----LGREGTFCQTASGQDGSGPFLA 1638
Query: 725 ---MFMKIQLPVVMHTEAEDVSLR------FRSQRAYGILMATTSR--DSADTLRLELDA 773
F ++L +HT A D+ + F ++ G+L+ + D + L L
Sbjct: 1639 DFNGFSHLELR-GLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRD 1697
Query: 774 GRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTG 833
R++ +L KG + + + W V + R G+ L V D + G
Sbjct: 1698 RRLEFRYDL---------GKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLG 1748
Query: 834 QMAGDHTRLEFHN-IETGIITERRYL---SSVPSNFIGHLQSLTFNG------------- 876
+ HT L + G + L ++V S F G +Q ++ G
Sbjct: 1749 ESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQV 1808
Query: 877 ----------------------------MAYIDLCKNG-DIDYCE---LNARFGFRNIIA 904
AY+ LC G +CE + G + +A
Sbjct: 1809 DVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLA 1868
Query: 905 -DPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYN--SGDGNDFIVVELVKGY 961
D TF + V + +A S H +T + GL+L++ + + D++ + +V G+
Sbjct: 1869 FDGRTFVEYLNAVT-ESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGH 1927
Query: 962 LHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRD-TSNLHTVKIDTKITTQITAGARNL 1020
L ++LG+ +++ S P+N N+W V+ R+ V + +T GA L
Sbjct: 1928 LQLSYNLGSQPVVLR--STVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQL 1985
Query: 1021 DLKSDLYIGGVAK-ETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDAL 1070
D L++GG+ + +LPK GF GCL V + L+ DA+
Sbjct: 1986 DTDGALWLGGLPELPVGPALPKAYGT--GFVGCLRDVVVGRHPLHLLEDAV 2034
Score = 87.4 bits (215), Expect = 9e-17
Identities = 92/411 (22%), Positives = 168/411 (40%), Gaps = 68/411 (16%)
Query: 902 IIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKG 960
++ PV S++A TL+AY ++ L +F+ GL+LYN + G DF+ + L+ G
Sbjct: 1369 VLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDG 1428
Query: 961 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKID--TKITTQITAGAR 1018
+ FD G+G ++ +S P+ QWH + +SR T+ +D T + + +G
Sbjct: 1429 RVQLRFDTGSGPAVL--TSAVPVEPGQWHRLELSRHWRR-GTLSVDGETPVLGESPSGTD 1485
Query: 1019 NLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGR----------------- 1061
L+L +DL++GGV ++ + G +GC+ +D+N +
Sbjct: 1486 GLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGV 1545
Query: 1062 --------LPDLISDALFCN-------------GQIERGCEGPSTTCQEDSCSNQGVC-L 1099
LP+ C G++ C + CQ + C C +
Sbjct: 1546 GECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRV 1605
Query: 1100 QQWDGFSCDC------------SMTSFSGPLCND-PGTTYIFSKGGGQITYKWPPNDRPS 1146
G C+C S SGP D G +++ + G T+ ++ +
Sbjct: 1606 LPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELR--GLHTFARDLGEKMA 1663
Query: 1147 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 1206
LA G S + +L + G GD++ L + ++ ++++G A+ S
Sbjct: 1664 LEVVFLARGPSGL----LLYNGQKTDGKGDFVSLALRDRRLEFRYDLG-KGAAVIRSREP 1718
Query: 1207 INDGKYHVVRFTRSGGNATLQVDSWP-VIERYPAGRQLTIFNSQATIIIGG 1256
+ G + V R+G L+V P V+ P T+ N + + +GG
Sbjct: 1719 VTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPH--TVLNLKEPLYVGG 1767
Score = 65.9 bits (159), Expect = 3e-10
Identities = 78/347 (22%), Positives = 133/347 (38%), Gaps = 30/347 (8%)
Query: 927 MHLFFQFKTTSLDGLILYNSG--DGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPL 983
M L F GL+LYN DG DF+ + L L + +DLG GA +I+ S +P+
Sbjct: 1662 MALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIR--SREPV 1719
Query: 984 NDNQWHNVMISRD-TSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKL 1042
W V + R+ V ++ + L+LK LY+GG + L +
Sbjct: 1720 TLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGA--PDFSKLARA 1777
Query: 1043 VHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQW 1102
GF G + V L GR L + + + P T C N C+ +
Sbjct: 1778 AAVSSGFDGAIQLVSLGGR-QLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPRE 1836
Query: 1103 DGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQIT------------YKWPPNDRPSTRAD 1150
+ C C FSGP C + K G + + +++
Sbjct: 1837 AAYVCLCP-GGFSGPHCEKG----LVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSN 1891
Query: 1151 RLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDG 1210
+ T + +++ ++ DY+ L I G + + +N+G+ + + S +N
Sbjct: 1892 HFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVL-RSTVPVNTN 1950
Query: 1211 KYHVVRFTRSGGNATLQV-DSWPVIERYPAGRQLTIFNSQATIIIGG 1256
++ V R +LQV + PV P G T ++ + +GG
Sbjct: 1951 RWLRVVAHREQREGSLQVGNEAPVTGSSPLG--ATQLDTDGALWLGG 1995
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 19/207 (9%)
Query: 667 GVKPSCSKETAKPCLSNPCKNNGMCRDGW---NRYVCDCSGTGYLGRSCER--EATVLSY 721
G +P ++ KPC S PC + G C+D W + C C G G CE+ A V ++
Sbjct: 1320 GRRPPAPQQPPKPCDSQPCFHGGTCQD-WALGGGFTCSCP-AGRGGAVCEKVLGAPVPAF 1377
Query: 722 DGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVN 781
+G F+ HT ++L FR+ G+L+ + D L L L GRV+L
Sbjct: 1378 EGRSFLAFPTLRAYHTLR--LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQL--- 1432
Query: 782 LDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTR 841
++ GP L + + +WH + + R + L+VD + + G+
Sbjct: 1433 ------RFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDG 1486
Query: 842 LEFH-NIETGIITERRYLSSVPSNFIG 867
L ++ G + E + ++ F+G
Sbjct: 1487 LNLDTDLFVGGVPEDQAAVALERTFVG 1513
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo
sapiens]
Length = 1308
Score = 134 bits (338), Expect = 5e-31
Identities = 115/454 (25%), Positives = 196/454 (43%), Gaps = 75/454 (16%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 341
+ G Y Q + D I+L FKT+Q +G++LH G + D++ L L+ +
Sbjct: 183 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 242
Query: 342 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
L+IN G + VN +D WH V + R +Q V +VD
Sbjct: 243 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQ--------VNFTVDEHRHH 294
Query: 398 TGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVS---NNFMGCLKEVVYKNNDVRLELSR 454
+ + ++ ++ D GG P+ PG VS NF GCL+ + Y D+
Sbjct: 295 F-HARGEFNLMNLDYEISFGGIPA----PGKSVSFPHRNFHGCLENLYYNGVDI----ID 345
Query: 455 LAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPN 514
LAKQ P++ G V+F C ++ P+TF + S+++LP ++ ++ S +F FRT
Sbjct: 346 LAKQQKPQIIAMGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKA 404
Query: 515 GLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK----- 569
GL+LFS ++++ G + L L G K+K+ L +
Sbjct: 405 GLLLFSE---------------------LQLISGGILLFLSDG----KLKSNLYQPGKLP 439
Query: 570 --------VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN 621
+NDG+W+ V +++V+ E + Y GG P+
Sbjct: 440 SDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDK 499
Query: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIR--QMAEVQSTAGVK-PSCSKETAK 678
G + + G+ GC+R + I G+ D+ Q + + + ++ SC +
Sbjct: 500 SFGSKCKSPLG------GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCG--ISD 551
Query: 679 PCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 712
CL N C++ G C W+ + C+C+ TGY G +C
Sbjct: 552 RCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATC 585
Score = 131 bits (330), Expect = 4e-30
Identities = 125/463 (26%), Positives = 206/463 (44%), Gaps = 61/463 (13%)
Query: 712 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 770
C + V+ DG + + + +D+ SL+F++ ++ GIL+ + D + L+
Sbjct: 177 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 235
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
L R+ L +N ++ S+ TL G L+D WH+V + R GK + TVD+ +
Sbjct: 236 LRRARLFLLINSGEAKLPSTSTLVNLTL--GSLLDDQHWHSVLIQRLGKQVNFTVDEHRH 293
Query: 831 MTGQMAGDHTRLEFHNIET-------GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLC 883
H R EF+ + GI + +S NF G L++L +NG+ IDL
Sbjct: 294 HF------HARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLA 347
Query: 884 KNGDIDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLI 942
K + N F + PVTF + SY+AL + FQF+T + GL+
Sbjct: 348 KQQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLL 407
Query: 943 LYNSGDGNDFIVVELVKG-YLHYVFDLGNGANLIKG-------SSNKPLNDNQWHNVMIS 994
L++ ++L+ G L ++ D +NL + ++ LND QWH+V +S
Sbjct: 408 LFSE--------LQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLS 459
Query: 995 RDTSNLHTVKIDTKITTQITA-GARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCL 1053
++L +V +D ++ + G + Y GG +++ S K GFQGC+
Sbjct: 460 AKKNHL-SVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCM 516
Query: 1054 ASVDLNGRLPDLISDAL-----FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCD 1108
+ ++G++ DLIS F + QI+ C G S C + C + G C Q W F C+
Sbjct: 517 RLISISGKVVDLISVQQGSLGNFSDLQID-SC-GISDRCLPNYCEHGGECSQSWSTFHCN 574
Query: 1109 CSMTSFSGPLC----------------NDPGTTYIFSKGGGQI 1135
C+ T + G C N G YI S G G +
Sbjct: 575 CTNTGYRGATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSGPL 617
Score = 114 bits (286), Expect = 5e-25
Identities = 95/343 (27%), Positives = 155/343 (45%), Gaps = 39/343 (11%)
Query: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG-YLHYVF 966
+F T++SY+ T S + F FKTT+ G+ L N G DFI +EL + + F
Sbjct: 796 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 854
Query: 967 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1024
D+GNG I S NDNQWH+V + R+ ++L ++ K G L L S
Sbjct: 855 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNS 914
Query: 1025 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1084
L++GG A + GF GC+ S+ LNG DL A +++ GC G
Sbjct: 915 QLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDLEERAQV-TPEVQPGCRGHC 962
Query: 1085 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDR 1144
++ + C N G C ++ GF CDC+ ++++GP C++ + Y S G + Y + N
Sbjct: 963 SSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGS--GSSVIYNFQENYL 1019
Query: 1145 PSTRA---------------DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQG---K 1186
S + + + F T + ++L+ V SS +YL + I + +
Sbjct: 1020 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFV--SSFYKEYLSVIIAKNGSLQ 1077
Query: 1187 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1229
I K N + + + DG+ H + R G +++D
Sbjct: 1078 IRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1120
Score = 97.4 bits (241), Expect = 9e-20
Identities = 90/394 (22%), Positives = 165/394 (41%), Gaps = 69/394 (17%)
Query: 464 KIHGVVAFK-----CENVATL-DPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLI 517
++H A+K C+ + + +F+T S++ P ++ + + +SF F+TT +G+
Sbjct: 771 RLHSEAAYKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVF 830
Query: 518 LFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLL-LDMGSGTIKIKALLKK-VNDGEW 575
L + G DF IE+ + D+G+G +I ND +W
Sbjct: 831 LENLGI--------------ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQW 876
Query: 576 YHVDFQRDGRSGTISVNTLRTPYTAPGESE---ILDLDDELYLGGLPENKAGLVFPTEVW 632
+HV +R+ + ++ V+ L TP T P ++ +L L+ +L++GG
Sbjct: 877 HHVRVERNMKEASLQVDQL-TPKTQPAPADGHVLLQLNSQLFVGG--------------- 920
Query: 633 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 692
TA G++GCIR L ++G + D+ + A+V T V+P C + C+N G CR
Sbjct: 921 TATRQRGFLGCIRSLQLNGMTLDLEERAQV--TPEVQPGCRGHCSS--YGKLCRNGGKCR 976
Query: 693 DGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFM----------------KIQLPVVMH 736
+ + CDC+ + Y G C E + GS + M
Sbjct: 977 ERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMK 1036
Query: 737 TEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPE 796
E + FR+ R +L+ +S + G ++ IR N + P+
Sbjct: 1037 LSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQ-------IRYKLNKYQEPD 1089
Query: 797 TL-FAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQ 829
+ F N+ D + H + + R + + +DD +
Sbjct: 1090 VVNFDFKNMADGQLHHIMINREEGVVFIEIDDNR 1123
Score = 72.8 bits (177), Expect = 2e-12
Identities = 78/346 (22%), Positives = 141/346 (40%), Gaps = 43/346 (12%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++SF KT ++ G+ L ++ G DF+ + L + SF +
Sbjct: 800 EASYLHFPTFHGELSADVSFFFKTTASSGVFL--ENLGIADFIRIELRSPTVVTFSFDVG 857
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRD-MTVFSGLF 154
++ + T ND WH VR+ R + +L +DQ+ K + + + S LF
Sbjct: 858 NGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLF 917
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
VGG + R+R F G IR +++N + + +V + +P
Sbjct: 918 VGG--------------TATRQR-GFLGCIRSLQLNGMTLDLEERAQVTPEVQP------ 956
Query: 215 SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEG----LAHLMM 270
C G +C NGG C CDC+ + + G CS E + G + +
Sbjct: 957 -GCRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQ 1015
Query: 271 GDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-SAD 329
+ SK + A+F G ++ S + I SF+T + L+L +
Sbjct: 1016 ENYLLSKNSSSHAASFHGD-----------MKLSREMIKFSFRTTRTPSLLLFVSSFYKE 1064
Query: 330 YVNLAL-KNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTR 374
Y+++ + KNG++ + L +V D H + + R
Sbjct: 1065 YLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNMADGQLHHIMINR 1110
Score = 62.0 bits (149), Expect = 4e-09
Identities = 91/382 (23%), Positives = 152/382 (39%), Gaps = 78/382 (20%)
Query: 741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLF- 799
DVS F++ + G+ + AD +R+EL + V + + + GP +
Sbjct: 816 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV--------VTFSFDVGNGPFEISV 865
Query: 800 -AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD-HTRLEFHN--IETGIITER 855
+ + NDN+WH VRV R K L VD T D H L+ ++ G T +
Sbjct: 866 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQ 925
Query: 856 RYLSSVPSNFIGHLQSLTFNGM-----------------------AYIDLCKNGDI---- 888
R F+G ++SL NGM +Y LC+NG
Sbjct: 926 R-------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRER 978
Query: 889 ---------------DYC--ELNARFG-----FRNIIADPVTFKTKSSYVALATLQAYTS 926
+C E++A FG N + + K SS+ A S
Sbjct: 979 PIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 1038
Query: 927 MHLF-FQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYVFDLGNGANL-IKGSSNKPL 983
+ F F+TT L+L+ S +++ V + K G L + L + K +
Sbjct: 1039 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNM 1098
Query: 984 NDNQWHNVMISRDTSNLHTVKIDTKITTQI--TAGARNLDLKSDLYIGGVAKETYKSLPK 1041
D Q H++MI+R+ + ++ID Q+ ++G +KS L +G + + +
Sbjct: 1099 ADGQLHHIMINRE-EGVVFIEIDDNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDT 1156
Query: 1042 LVHAKEGFQGCLASVDLNGRLP 1063
+ +GF GCL++V L+ P
Sbjct: 1157 ALAGAQGFTGCLSAVQLSHVAP 1178
Score = 55.5 bits (132), Expect = 4e-07
Identities = 41/155 (26%), Positives = 76/155 (49%), Gaps = 21/155 (13%)
Query: 305 SDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAV-SLVINLGSGAFEALVEPVNGKFN 363
S +++ FKT +G+ L AD++ + L++ V + ++G+G FE V+ FN
Sbjct: 814 SADVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT-HFN 872
Query: 364 DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQED-YTMLGSDDFFYVGGSPST 422
DN WH V+V RN+++ S + VD + T D + +L + +VGG+ +
Sbjct: 873 DNQWHHVRVERNMKEAS--------LQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATR 924
Query: 423 ADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 457
F+GC++ + + N + L+L A+
Sbjct: 925 --------QRGFLGCIRSL--QLNGMTLDLEERAQ 949
Score = 53.1 bits (126), Expect = 2e-06
Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 18/169 (10%)
Query: 1150 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVG------TDDIAIEES 1203
D +++ F T+Q + +L+ + +G D++ L + + ++ + N G T +
Sbjct: 206 DIISLKFKTMQSDGILLHREGPNG--DHITLQLRRARLFLLINSGEAKLPSTSTLVNLTL 263
Query: 1204 NAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG-----KE 1258
++++D +H V R G VD + A + + N I GG K
Sbjct: 264 GSLLDDQHWHSVLIQRLGKQVNFTVDEHR--HHFHARGEFNLMNLDYEISFGGIPAPGKS 321
Query: 1259 QGQP---FQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSM 1304
P F G L LYYNG+ ++++A + I +GNV P SM
Sbjct: 322 VSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNVSFSCSQPQSM 370
Score = 52.0 bits (123), Expect = 4e-06
Identities = 50/210 (23%), Positives = 91/210 (43%), Gaps = 20/210 (9%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
E +FQ +T + GL+L+ + + + L L+ G+L+ + P+ + A +N
Sbjct: 391 EVSATFQFRTWNKAGLLLFSELQLISGGILLFLS-DGKLKSNLYQPGKLPSDITAGVELN 449
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALK 168
DG WHSV + + + ++ +D A + + ++SG + GG P + + K
Sbjct: 450 DGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQ---IYSGGTYYFGGCPDKSFGSKCK 506
Query: 169 LTLASVREREPFKGWIRDVRVNSSQV--LPVDSGEV-KLDDEPPNSGGGSPCEAGEEGEG 225
L F+G +R + ++ V + V G + D +S C +
Sbjct: 507 SPLGG------FQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDS-----CGISDRCLP 555
Query: 226 GVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
C +GG CS C+C+ TG+RG C
Sbjct: 556 NYCEHGGECSQSWSTFHCNCTNTGYRGATC 585
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 134 bits (336), Expect = 8e-31
Identities = 119/451 (26%), Positives = 191/451 (42%), Gaps = 69/451 (15%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 341
I F G + Y + +S D SFKT +++GL+LH G DYV L L+ +
Sbjct: 174 ILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLL 233
Query: 342 LVINLGSGAFEA----LVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
L ++LGS + G ND WH V+V R R D T
Sbjct: 234 LHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGR--------------DVNFTL 279
Query: 398 TGYTQE-----DYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLEL 452
GY Q D+ L D ++GG A +NF GC++ V++ R+ +
Sbjct: 280 DGYVQRFILNGDFERLNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN----RVNI 334
Query: 453 SRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTE 512
+ LA + ++ G VAF+C + PI F P +F+ +P + + ++SF FRT +
Sbjct: 335 ADLAVRRHSRITFEGKVAFRCLDPVP-HPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWD 393
Query: 513 PNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIK-ALLKKVN 571
GL+LFS R H + + + +G + + + SG K++ A ++N
Sbjct: 394 LTGLLLFS----RLGDGLGHVE--------LTLSEGQVNVSIAQ-SGRKKLQFAAGYRLN 440
Query: 572 DGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEV 631
DG W+ V+F IS++ + ++ + GG P+ P
Sbjct: 441 DGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPK-------PASR 493
Query: 632 WTALLNY-GYVGCIRDLFIDGQSKDIRQM--------AEVQ-STAGVKPSCSKETAKPCL 681
W N + GC+ L +DGQ ++ + AEV T G+ CS
Sbjct: 494 WDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCS-------- 545
Query: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 712
N C+++G C W+ ++C C TGY G +C
Sbjct: 546 PNMCEHDGRCYQSWDDFICYCELTGYKGETC 576
Score = 107 bits (267), Expect = 8e-23
Identities = 106/425 (24%), Positives = 184/425 (43%), Gaps = 27/425 (6%)
Query: 712 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 770
C +A +L +DG + + P + DV + F+++ G+L+ D + LE
Sbjct: 168 CPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG-DYVTLE 226
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
L+ + L ++L I G T+ AG LND WH VRV R G+ + T+D
Sbjct: 227 LEGAHLLLHMSLGSSPIQ--PRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY-V 283
Query: 831 MTGQMAGDHTRLEFHNIET-----GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLC-- 883
+ GD RL N++T G++ R + NF G ++++ FN + DL
Sbjct: 284 QRFILNGDFERL---NLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVR 340
Query: 884 KNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLIL 943
++ I + E F + + P+ F ++V + + + F+F+T L GL+L
Sbjct: 341 RHSRITF-EGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLL 399
Query: 944 YNS-GDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHT 1002
++ GDG + + L +G ++ V +G ++ ++ LND WH V N
Sbjct: 400 FSRLGDGLGHVELTLSEGQVN-VSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQ-ENHAV 457
Query: 1003 VKIDTKITTQITAGARNLDLKSDLYI-GGVAKETYKSLPKLVHAKE-GFQGCLASVDLNG 1060
+ ID ++ L Y GG K + H+ + F GC+ + ++G
Sbjct: 458 ISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWD---CHSNQTAFHGCMELLKVDG 514
Query: 1061 RLPDLI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGP 1117
+L +L L ++ G + C + C + G C Q WD F C C +T + G
Sbjct: 515 QLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGE 574
Query: 1118 LCNDP 1122
C+ P
Sbjct: 575 TCHTP 579
Score = 82.0 bits (201), Expect = 4e-15
Identities = 119/527 (22%), Positives = 204/527 (38%), Gaps = 130/527 (24%)
Query: 886 GDIDYCELNARFGFRNI--IADPVTFKTKSSYVALAT----LQAYTSMHLFFQFKTTSLD 939
GD + A+F R + D ++ T S + A ++A S+ + F F+T++
Sbjct: 760 GDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPS 819
Query: 940 GLILYNSGDG-----NDFIVVEL-VKGYLHYVFDLGNG-ANLIKGSSNKPLNDNQWHNVM 992
G+ L N G ++ VEL + + FD+GNG NL S + ND++WH V
Sbjct: 820 GVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVR 879
Query: 993 ISRDTSNLHTVKIDTKITTQITAGARN---LDLKSDLYIGGVAKETYKSLPKLVHAKEGF 1049
+ +++D + + ++ LY+G + + F
Sbjct: 880 AEINVKQAR-LRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELK-----------RRPF 927
Query: 1050 QGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDS------CSNQGVCLQQWD 1103
GCL ++ LNG +L A EG S C C + G C++++
Sbjct: 928 VGCLRAMRLNGVTLNLEGRA--------NASEGTSPNCTGHCAHPRLPCFHGGRCVERYS 979
Query: 1104 GFSCDCSMTSFSGPLCN-------DPGT-----------------TYIFSK--------- 1130
++CDC +T+F GP CN +PGT +++ S+
Sbjct: 980 YYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGY 1039
Query: 1131 --------------GGGQITYKWPPNDRP---------STRADRLAIGFSTVQKEAVLVR 1167
G G +P RP + + ++ FST AVL+
Sbjct: 1040 IPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLY 1099
Query: 1168 VDSSSGLGDYLELHI-HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATL 1226
V SS + DY+ + I G + +++ +GT + + + DG+ H + TR N +
Sbjct: 1100 V--SSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFI 1157
Query: 1227 QVDSWPVIE---------RYPAGRQLTIFNSQATIIIGGKEQ---GQPFQGQLSGLYYNG 1274
QVD +P+ E + + + L + T +I + Q F G LSG+ +N
Sbjct: 1158 QVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNN 1217
Query: 1275 LKVLN--------MAAENDANIAIVGNV---------RLVGEVPSSM 1304
+ L M AE + + G + RLV EVP +
Sbjct: 1218 VAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPEL 1264
Score = 61.2 bits (147), Expect = 7e-09
Identities = 61/268 (22%), Positives = 118/268 (44%), Gaps = 36/268 (13%)
Query: 482 ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFF 541
I+F T + + P A + +SF FRT+ P+G+ L + G P Q + ++V+
Sbjct: 788 ISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPY---VRVELN 843
Query: 542 AIEMLDGHLYLLLDMGSG--TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYT 599
+ D+G+G + + + + ND EW+ V + + + + V+ P+
Sbjct: 844 TSR----DVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVD--HRPWV 897
Query: 600 A---PGESEI-LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKD 655
P ++ I ++ D LY+G L +VGC+R + ++G + +
Sbjct: 898 LRPMPLQTYIWMEYDQPLYVGS---------------AELKRRPFVGCLRAMRLNGVTLN 942
Query: 656 IRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCERE 715
+ A ++ G P+C+ A P L PC + G C + ++ Y CDC T + G C +
Sbjct: 943 LEGRAN--ASEGTSPNCTGHCAHPRL--PCFHGGRCVERYSYYTCDCDLTAFDGPYCNHD 998
Query: 716 ATVLSYDGSMFMKIQLPVVMHTEAEDVS 743
++ +M+ L + + A + S
Sbjct: 999 IGGF-FEPGTWMRYNLQSALRSAAREFS 1025
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/193 (21%), Positives = 82/193 (42%), Gaps = 25/193 (12%)
Query: 1127 IFSKGGGQITYKWPPNDRPSTRA--DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQ 1184
++ G I+Y++P R +R+ D A F T +K+ +L+ + + G DY+ L +
Sbjct: 175 LYFDGDDAISYRFP---RGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG--DYVTLELEG 229
Query: 1185 GKIGVKFNVGTDDI------AIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYP 1238
+ + ++G+ I + ++ND +H VR R G + +D + ++R+
Sbjct: 230 AHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY--VQRFI 287
Query: 1239 AGRQLTIFNSQATIIIGG--------KEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1290
N + IGG F+G + + +N + + ++A + I
Sbjct: 288 LNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITF 347
Query: 1291 VGNV--RLVGEVP 1301
G V R + VP
Sbjct: 348 EGKVAFRCLDPVP 360
Score = 46.2 bits (108), Expect = 2e-04
Identities = 101/477 (21%), Positives = 170/477 (35%), Gaps = 87/477 (18%)
Query: 21 LGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCD--- 77
L C+ + S G RFP A ++SF +T + G+ L +C
Sbjct: 776 LRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRR 835
Query: 78 -FLELILTRGGRLQLSFSIFCAEPATLLA--DTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
++ + L + +F + + + D ND WH VR + L +D
Sbjct: 836 PYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDH-- 893
Query: 135 AKWVEVKSKRRDMTVFSGLFVG-GLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQ 193
WV R M + + +++ P + +A LK R PF G +R +R+N
Sbjct: 894 RPWV-----LRPMPLQTYIWMEYDQPLYVGSAELK--------RRPFVGCLRAMRLNGVT 940
Query: 194 VLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGV-CLNGGVCSVVDDQAVCDCSRTGFRG 252
+ L+ S G SP G + C +GG C CDC T F G
Sbjct: 941 L--------NLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDG 992
Query: 253 KDCSQE-------------------DNNVEGLAHLMMG-----DQGKSKGKEE--YIATF 286
C+ + + +H++ + G G + Y+ +
Sbjct: 993 PYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGY 1052
Query: 287 KGSEYFCYDLS---------QNPIQS-SSDEITLSFKTLQRNGLMLHTGKSA-DYVNLAL 335
G Y D + P+ + + +E++ SF T ++L+ DY+ + +
Sbjct: 1053 HGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLI 1112
Query: 336 K-NGAVSLVINLGSG--AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVD 392
K +G + L LG+ ++ PV D H + +TR R + I VD
Sbjct: 1113 KDDGTLQLRYQLGTSPYVYQLTTRPV----TDGQPHSINITRVYRN--------LFIQVD 1160
Query: 393 GI-LTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNN---FMGCLKEVVYKN 445
LT ++ + L S Y+G T + N F GCL V + N
Sbjct: 1161 YFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNN 1217
Score = 42.7 bits (99), Expect = 0.003
Identities = 52/214 (24%), Positives = 78/214 (36%), Gaps = 34/214 (15%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+SF+ +T GL+L+ +EL L+ G ++ +S + + A +NDG
Sbjct: 385 VSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEG-QVNVSIAQSGRKKLQFAAGYRLNDGF 443
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLAS 173
WH V Q + + ID VE V V T S F GG P
Sbjct: 444 WHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTS-YFFGGCP-------------- 488
Query: 174 VREREPFKGWIRDVRVNSS------QVLPVDSGEVKLDDEPPNSGG------GSPCEAGE 221
+P W D N + ++L VD V L G C +
Sbjct: 489 ----KPASRW--DCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITD 542
Query: 222 EGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
+C + G C D +C C TG++G+ C
Sbjct: 543 RCSPNMCEHDGRCYQSWDDFICYCELTGYKGETC 576
Score = 34.7 bits (78), Expect = 0.70
Identities = 45/168 (26%), Positives = 73/168 (43%), Gaps = 20/168 (11%)
Query: 31 LEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDD-EGFCDFLELILTRGGR 88
L F G + RFP+ + +F KT GL+L+ + +G LEL G
Sbjct: 175 LYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLEL---EGAH 231
Query: 89 LQLSFSIFCA--EP----ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKS 142
L L S+ + +P T+ A +ND WH VR+ R R+ +D +++ +
Sbjct: 232 LLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFI-LNG 290
Query: 143 KRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVN 190
+ + + +F+GGL A + LA R F+G I +V N
Sbjct: 291 DFERLNLDTEMFIGGL-----VGAARKNLA---YRHNFRGCIENVIFN 330
Score = 32.7 bits (73), Expect = 2.7
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 7/101 (6%)
Query: 729 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN 788
++ P + + DVS FR+ G+ + R + RV+L + D +
Sbjct: 796 LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYV---RVELNTSRDVV-FA 851
Query: 789 CNSSKGPETLFA---GYNLNDNEWHTVRVVRRGKSLKLTVD 826
+ G E L + ND+EWH VR K +L VD
Sbjct: 852 FDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVD 892
Score = 31.2 bits (69), Expect = 7.7
Identities = 40/169 (23%), Positives = 70/169 (41%), Gaps = 25/169 (14%)
Query: 300 PIQSS-SDEITLSFKTLQRNGLMLHTGKSA------DYVNLALKNGA-VSLVINLGSGAF 351
PI+++ S +++ F+T +G+ L YV + L V ++G+G
Sbjct: 800 PIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDE 859
Query: 352 EALVEPVNGKFNDNAWHDVKVTRNLRQ-HSGIGHAMVTISVDGILTTTGYTQEDYTMLGS 410
V + +FND+ WH V+ N++Q + H + + T Y +
Sbjct: 860 NLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQT--------YIWMEY 911
Query: 411 DDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQG 459
D YVG +A+L P F+GCL+ + + LE A +G
Sbjct: 912 DQPLYVG----SAELKRRP----FVGCLRAMRLNGVTLNLEGRANASEG 952
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 131 bits (330), Expect = 4e-30
Identities = 163/761 (21%), Positives = 311/761 (40%), Gaps = 137/761 (18%)
Query: 192 SQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFR 251
S+++P S + + P P +G+ GV + + + D+ +C S F
Sbjct: 72 SRLIPPTSASLPVTTVAPQ-----PIPIQRKGKNGVAIMSRLFDMPCDETLC--SADSFC 124
Query: 252 GKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEIT 309
D + + + +G G+S ++ I F G Y ++ +N Q+ +IT
Sbjct: 125 VNDYTWGGSRCQ----CTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QIT 178
Query: 310 LSFKTLQRNGLMLHTGKS----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 365
L F+ +GL+L+ G++ D+++LA+ ++ N G+G + E K
Sbjct: 179 LEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLG 235
Query: 366 AWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+PS L
Sbjct: 236 GWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWL 287
Query: 426 PGSPVSNN-FMGCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VV 469
+ +N F GC++ + + + L K D IHG
Sbjct: 288 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 347
Query: 470 AFKCENVATLDPITF-----------------ETPESFISLPKWNAKKTGSISF-----D 507
A K ++ L P+ F E+ S+ + P W + +SF
Sbjct: 348 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEIT 406
Query: 508 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 567
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 407 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 453
Query: 568 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 621
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 454 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 513
Query: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 681
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 514 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 555
Query: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 737
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 556 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 614
Query: 738 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 791
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 615 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 665
Query: 792 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 847
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 666 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 725
Query: 848 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 885
E + T R+Y+ + +G + T + +I L ++
Sbjct: 726 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 762
Score = 121 bits (304), Expect = 4e-27
Identities = 152/650 (23%), Positives = 256/650 (39%), Gaps = 101/650 (15%)
Query: 679 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 734
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 112 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 169
Query: 735 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 794
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 170 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 222
Query: 795 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 854
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 223 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 274
Query: 855 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 887
YL PS F G +QSL NG A + C +G
Sbjct: 275 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 334
Query: 888 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 926
D I AD P+ FK + A +L++Y +
Sbjct: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 394
Query: 927 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 979
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 395 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 452
Query: 980 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1037
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 453 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 509
Query: 1038 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1097
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 510 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 564
Query: 1098 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1153
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 565 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 623
Query: 1154 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1211
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 624 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 682
Query: 1212 YHVVRFTRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIIIGGKEQ 1259
+H V+ R G + + VD + G RQL N + +GG ++
Sbjct: 683 WHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGGMKE 729
Score = 105 bits (262), Expect = 3e-22
Identities = 102/382 (26%), Positives = 161/382 (42%), Gaps = 33/382 (8%)
Query: 914 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 969
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
Query: 970 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1028
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 221 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
Query: 1029 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1085
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
Query: 1086 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1141
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
Query: 1142 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1201
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 450
Query: 1202 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG----- 1256
S + G +H +R +R+ N LQVD ++E G T I IGG
Sbjct: 451 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPNYD 509
Query: 1257 ---KEQG--QPFQGQLSGLYYN 1273
K G +PF G + + N
Sbjct: 510 DVKKNSGVLKPFSGSIQKIILN 531
Score = 103 bits (256), Expect = 2e-21
Identities = 109/404 (26%), Positives = 164/404 (40%), Gaps = 73/404 (18%)
Query: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 455
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 456 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 515
Query: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
LK PF G I+ + +N + VK D + G + A
Sbjct: 516 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 555
Query: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA 284
C +GG C + CDC GF G C + +E + I
Sbjct: 556 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKA--IIEAIE----------------IP 596
Query: 285 TFKGSEYFCYDLSQNP-----IQSSSDEITLSFKTLQRNGLMLHTGKS-----ADYVNLA 334
F G Y YD NP + S + + FKT ++GL+L G S +D+++L
Sbjct: 597 QFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 653
Query: 335 LKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGI 394
L++GA+ NLGSG + VNG FND WH VK R+ SG I+VD
Sbjct: 654 LRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRD--GQSG------KITVDDY 702
Query: 395 LTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
TG + L + YVGG A +GC+
Sbjct: 703 GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 746
Score = 102 bits (253), Expect = 4e-21
Identities = 145/627 (23%), Positives = 259/627 (41%), Gaps = 114/627 (18%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 167 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 223
Query: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 282
Query: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 283 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 327
Query: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQG 274
GE G C++GG C+ + D +C C GF+G+ C A + Q
Sbjct: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCED--------AFTLTIPQF 378
Query: 275 KSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH---TGKSADYV 331
+ + Y AT E Y S E ++F+ +G++L+ TG S D++
Sbjct: 379 R-ESLRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFL 428
Query: 332 NLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISV 391
++ L G V + GSG E N WH+++V+R + +GI + V
Sbjct: 429 SINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAK--NGI------LQV 477
Query: 392 DGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL-PGSPVSNNFMGCLKEVVYKNNDVRL 450
D G + +T + + ++GG P+ D+ S V F G +++++ + + +
Sbjct: 478 DKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHV 537
Query: 451 E-------------------------LSRLAKQG---DPKMKIHGVVAFKCENVATLDP- 481
+ R K+G D + G+ K A P
Sbjct: 538 KHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQ 597
Query: 482 ------ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQM 535
+T++ P+ + K + ++ F+TT +GL+L+ P
Sbjct: 598 FIGRSYLTYDNPD----ILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS------ 647
Query: 536 IKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT-- 593
DF ++ + DG L ++GSG I + NDG W+ V RDG+SG I+V+
Sbjct: 648 ---DFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYG 703
Query: 594 LRTPYTAPGESEILDLDDELYLGGLPE 620
RT +PG L+++ LY+GG+ E
Sbjct: 704 ARTG-KSPGMMRQLNINGALYVGGMKE 729
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 131 bits (330), Expect = 4e-30
Identities = 163/761 (21%), Positives = 311/761 (40%), Gaps = 137/761 (18%)
Query: 192 SQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFR 251
S+++P S + + P P +G+ GV + + + D+ +C S F
Sbjct: 306 SRLIPPTSASLPVTTVAPQ-----PIPIQRKGKNGVAIMSRLFDMPCDETLC--SADSFC 358
Query: 252 GKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEIT 309
D + + + +G G+S ++ I F G Y ++ +N Q+ +IT
Sbjct: 359 VNDYTWGGSRCQ----CTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QIT 412
Query: 310 LSFKTLQRNGLMLHTGKS----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 365
L F+ +GL+L+ G++ D+++LA+ ++ N G+G + E K
Sbjct: 413 LEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLG 469
Query: 366 AWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+PS L
Sbjct: 470 GWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWL 521
Query: 426 PGSPVSNN-FMGCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VV 469
+ +N F GC++ + + + L K D IHG
Sbjct: 522 VRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCT 581
Query: 470 AFKCENVATLDPITF-----------------ETPESFISLPKWNAKKTGSISF-----D 507
A K ++ L P+ F E+ S+ + P W + +SF
Sbjct: 582 AIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEIT 640
Query: 508 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 567
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 641 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 687
Query: 568 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 621
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 688 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 747
Query: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 681
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 748 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 789
Query: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 737
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 790 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 848
Query: 738 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 791
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 849 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 899
Query: 792 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 847
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 900 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 959
Query: 848 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 885
E + T R+Y+ + +G + T + +I L ++
Sbjct: 960 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 996
Score = 121 bits (304), Expect = 4e-27
Identities = 152/650 (23%), Positives = 256/650 (39%), Gaps = 101/650 (15%)
Query: 679 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 734
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 346 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 403
Query: 735 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 794
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 404 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 456
Query: 795 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 854
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 457 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 508
Query: 855 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 887
YL PS F G +QSL NG A + C +G
Sbjct: 509 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 568
Query: 888 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 926
D I AD P+ FK + A +L++Y +
Sbjct: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 628
Query: 927 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 979
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 629 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 686
Query: 980 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1037
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 687 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 743
Query: 1038 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1097
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 744 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 798
Query: 1098 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1153
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 799 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 857
Query: 1154 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1211
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 858 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 916
Query: 1212 YHVVRFTRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIIIGGKEQ 1259
+H V+ R G + + VD + G RQL N + +GG ++
Sbjct: 917 WHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGGMKE 963
Score = 105 bits (262), Expect = 3e-22
Identities = 102/382 (26%), Positives = 161/382 (42%), Gaps = 33/382 (8%)
Query: 914 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 969
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
Query: 970 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1028
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 455 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
Query: 1029 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1085
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
Query: 1086 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1141
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
Query: 1142 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1201
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 684
Query: 1202 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG----- 1256
S + G +H +R +R+ N LQVD ++E G T I IGG
Sbjct: 685 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPNYD 743
Query: 1257 ---KEQG--QPFQGQLSGLYYN 1273
K G +PF G + + N
Sbjct: 744 DVKKNSGVLKPFSGSIQKIILN 765
Score = 103 bits (256), Expect = 2e-21
Identities = 109/404 (26%), Positives = 164/404 (40%), Gaps = 73/404 (18%)
Query: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 689
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 690 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 749
Query: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
LK PF G I+ + +N + VK D + G + A
Sbjct: 750 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 789
Query: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIA 284
C +GG C + CDC GF G C + +E + I
Sbjct: 790 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKA--IIEAIE----------------IP 830
Query: 285 TFKGSEYFCYDLSQNP-----IQSSSDEITLSFKTLQRNGLMLHTGKS-----ADYVNLA 334
F G Y YD NP + S + + FKT ++GL+L G S +D+++L
Sbjct: 831 QFIGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLG 887
Query: 335 LKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGI 394
L++GA+ NLGSG + VNG FND WH VK R+ SG I+VD
Sbjct: 888 LRDGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRD--GQSG------KITVDDY 936
Query: 395 LTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
TG + L + YVGG A +GC+
Sbjct: 937 GARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 980
Score = 102 bits (253), Expect = 4e-21
Identities = 145/627 (23%), Positives = 259/627 (41%), Gaps = 114/627 (18%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 401 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 457
Query: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 458 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 516
Query: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 517 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 561
Query: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQG 274
GE G C++GG C+ + D +C C GF+G+ C A + Q
Sbjct: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCED--------AFTLTIPQF 612
Query: 275 KSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH---TGKSADYV 331
+ + Y AT E Y S E ++F+ +G++L+ TG S D++
Sbjct: 613 R-ESLRSYAATPWPLEPQHY--------LSFMEFEITFRPDSGDGVLLYSYDTG-SKDFL 662
Query: 332 NLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISV 391
++ L G V + GSG E N WH+++V+R + +GI + V
Sbjct: 663 SINLAGGHVEFRFDCGSGTGVLRSEDPLTLGN---WHELRVSRTAK--NGI------LQV 711
Query: 392 DGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL-PGSPVSNNFMGCLKEVVYKNNDVRL 450
D G + +T + + ++GG P+ D+ S V F G +++++ + + +
Sbjct: 712 DKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHV 771
Query: 451 E-------------------------LSRLAKQG---DPKMKIHGVVAFKCENVATLDP- 481
+ R K+G D + G+ K A P
Sbjct: 772 KHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQ 831
Query: 482 ------ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQM 535
+T++ P+ + K + ++ F+TT +GL+L+ P
Sbjct: 832 FIGRSYLTYDNPD----ILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNS------ 881
Query: 536 IKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT-- 593
DF ++ + DG L ++GSG I + NDG W+ V RDG+SG I+V+
Sbjct: 882 ---DFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKAVRDGQSGKITVDDYG 937
Query: 594 LRTPYTAPGESEILDLDDELYLGGLPE 620
RT +PG L+++ LY+GG+ E
Sbjct: 938 ARTG-KSPGMMRQLNINGALYVGGMKE 963
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 127 bits (320), Expect = 6e-29
Identities = 130/475 (27%), Positives = 217/475 (45%), Gaps = 73/475 (15%)
Query: 907 VTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYV 965
V+F T++SY+ T A S + F FKTT+L G+ L N G DFI +E+ + +
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGI-KDFIRLEISSPSEITFA 851
Query: 966 FDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITA--GARNLDLK 1023
D+GNG + S LNDNQWH V R+ + +T+ T+ G L L
Sbjct: 852 IDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLN 911
Query: 1024 SDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGP 1083
S L++GG + ++GF GC+ S+ LNG+ DL A +G + GC G
Sbjct: 912 SQLFVGGTSSR-----------QKGFLGCIRSLHLNGQKMDLEERAKVTSG-VRPGCPGH 959
Query: 1084 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN-------DPGT--TYIFSKGGGQ 1134
++ C N G C+++ +G+ CDC+ + + GP C + GT TY+F Q
Sbjct: 960 CSS-YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMF-----Q 1013
Query: 1135 ITYKWPPNDRPSTRA---------DRLAIGFSTVQKEAVLVRVDSSSGLGDY-LELHIHQ 1184
Y N S+ A + +A+ F T Q ++L+ ++SSS D+ + L
Sbjct: 1014 EPYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINSSS--QDFVVVLLCKN 1071
Query: 1185 GKIGVKFNVGTDDIAIEESNA-IINDGKYHVVRFTRSGGNATLQVDSW--------PVIE 1235
G + V++++ ++ + +A + + H ++ R G T+Q+D P +E
Sbjct: 1072 GSLQVRYHLNKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQQLRLSYNFSPEVE 1131
Query: 1236 RYPAGRQLTIFNSQATIIIG-----GKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAI 1290
+ R LT+ + T +G K F G +S + YN + L AA A +A
Sbjct: 1132 -FRVIRSLTL--GKVTENLGLDSEVAKANAMGFAGCMSSVQYNHIAPLK-AALRHATVAP 1187
Query: 1291 VGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPIS 1345
V V ++T S + S+++ TT+ +S+ GK +EP++
Sbjct: 1188 V-------TVHGTLTESSCGFMVDSDVN-----AVTTVHSSSDPFGKTDEREPLT 1230
Score = 127 bits (318), Expect = 1e-28
Identities = 123/465 (26%), Positives = 200/465 (43%), Gaps = 65/465 (13%)
Query: 712 CEREATVLSYDGSMFMKIQL-PVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE 770
C ++ V +DG + + +M T + +SL+F+S + G+L + D + LE
Sbjct: 174 CSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQ-RGDHITLE 232
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQ-Q 829
L GR+ L +NL + +SS TL G L+D WH+V + R GK + TVD Q
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATL--GSLLDDQHWHSVLIERVGKQVNFTVDKHTQ 290
Query: 830 AMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDID 889
+ D +++ GI + + + NF G +++L +NG+ IDL K
Sbjct: 291 HFRTKGETDALDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQ 350
Query: 890 YCELNARFGFRNIIADPVTFKTKS-SYVALATLQAYTSMHLFFQFKTTSLDGLILYNS-G 947
N F P+TF S SY+ L + + FQF+T + DGL+L
Sbjct: 351 IYTGNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELS 410
Query: 948 DGNDFIVVELVKGYLHYVFD--LGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI 1005
+G+ +++ L G L V A ++ GS+ LND WH+V I+ + + T+ +
Sbjct: 411 EGSGTLLLSLEGGILRLVIQKMTERVAEILTGSN---LNDGLWHSVSINARRNRI-TLTL 466
Query: 1006 DTKIT--------TQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVD 1057
D + QI +G + Y GG S + ++ + FQGC+ +
Sbjct: 467 DDEAAPPAPDSTWVQIYSG-------NSYYFGGCPDNLTDS--QCLNPIKAFQGCMRLIF 517
Query: 1058 LNGRLPDLISDALFCNGQIERGCEGPSTT-----------CQEDSCSNQGVCLQQWDGFS 1106
++ + DLIS +++G G + C + C + G C Q W F
Sbjct: 518 IDNQPKDLIS--------VQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFY 569
Query: 1107 CDCSMTSFSGPLC----------------NDPGTTYIFSKGGGQI 1135
C+CS TS++G C N G YI S G G +
Sbjct: 570 CNCSDTSYTGATCHNSIYEQSCEVYRHQGNTAGFFYIDSDGSGPL 614
Score = 118 bits (296), Expect = 4e-26
Identities = 117/453 (25%), Positives = 193/453 (42%), Gaps = 73/453 (16%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-TGKSADYVNLALKNGAVS 341
+A F G Y +Q + + D I+L FK++Q +G++ H G+ D++ L L+ G ++
Sbjct: 180 VADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLA 239
Query: 342 LVINLGSGAFE---ALVEPVNGKF-NDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTT 397
L +NLG +L G +D WH V + R +Q V +VD T
Sbjct: 240 LHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQ--------VNFTVDKH-TQ 290
Query: 398 TGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 457
T+ + L D GG P PG+ + NF GC++ + Y ++ ++L++ K
Sbjct: 291 HFRTKGETDALDIDYELSFGGIPVPGK-PGTFLKKNFHGCIENLYYNGVNI-IDLAKRRK 348
Query: 458 QGDPKMKIH-GVVAFKCENVATLDPITF-ETPESFISLPKWNAKKTGSISFDFRTTEPNG 515
+I+ G V F C + PITF + S++ LP S+SF FRT +G
Sbjct: 349 H-----QIYTGNVTFSCSEPQIV-PITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDG 402
Query: 516 LILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIK--IKALLKKV--- 570
L+L + E+ +G LLL + G ++ I+ + ++V
Sbjct: 403 LLL-----------------------STELSEGSGTLLLSLEGGILRLVIQKMTERVAEI 439
Query: 571 ------NDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAG 624
NDG W+ V T++++ P + + Y GG P+N
Sbjct: 440 LTGSNLNDGLWHSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTD 499
Query: 625 LVFPTEVWTALLN--YGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAK---P 679
+ LN + GC+R +FID Q KD+ ++ Q + G +
Sbjct: 500 --------SQCLNPIKAFQGCMRLIFIDNQPKDL--ISVQQGSLGNFSDLHIDLCSIKDR 549
Query: 680 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 712
CL N C++ G C W + C+CS T Y G +C
Sbjct: 550 CLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATC 582
Score = 109 bits (273), Expect = 2e-23
Identities = 97/416 (23%), Positives = 187/416 (44%), Gaps = 53/416 (12%)
Query: 482 ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFF 541
++F T S++ P ++A+ + ISF F+TT +G+ L + G IK DF
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLG-------------IK-DFI 838
Query: 542 AIEMLD-GHLYLLLDMGSGTIKIKALLKKV-NDGEWYHVDFQRDGRSGTISVNTL--RTP 597
+E+ + +D+G+G +++ + ND +W++V +R+ + ++ V+ L T
Sbjct: 839 RLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTR 898
Query: 598 YTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIR 657
T+ L L+ +L++GG T+ G++GCIR L ++GQ D+
Sbjct: 899 ETSEEGHFRLQLNSQLFVGG---------------TSSRQKGFLGCIRSLHLNGQKMDLE 943
Query: 658 QMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT 717
+ A+V T+GV+P C + + C N G C + N Y+CDC+ + Y G C++E +
Sbjct: 944 ERAKV--TSGVRPGCPGHCSS--YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVS 999
Query: 718 VLSYDGS----MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDA 773
+ G+ MF + PV + ++ S + + + A +L L +++
Sbjct: 1000 AVFEAGTSVTYMFQE-PYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINS 1058
Query: 774 GRVKLTVNLDC------IRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 827
V L C +R + N + N + H +++ R G+ L + +D
Sbjct: 1059 SSQDFVVVLLCKNGSLQVRYHLNKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQ 1118
Query: 828 QQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPS-----NFIGHLQSLTFNGMA 878
Q ++ + + ++ G +TE L S + F G + S+ +N +A
Sbjct: 1119 QLRLSYNFSPEVEFRVIRSLTLGKVTENLGLDSEVAKANAMGFAGCMSSVQYNHIA 1174
Score = 80.5 bits (197), Expect = 1e-14
Identities = 86/351 (24%), Positives = 146/351 (41%), Gaps = 46/351 (13%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++A +++SF KT + G+ L ++ G DF+ L ++ + + +
Sbjct: 798 EASYLHFPTFHAEFSADISFFFKTTALSGVFL--ENLGIKDFIRLEISSPSEITFAIDVG 855
Query: 97 CAEPATLLADTP--VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGL 153
P L+ +P +ND WH VR R + T+L +D + E + + + S L
Sbjct: 856 NG-PVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQL 914
Query: 154 FVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGG 213
FVGG + ++ F G IR + +N ++ + +V SG
Sbjct: 915 FVGG---------------TSSRQKGFLGCIRSLHLNGQKMDLEERAKV-------TSGV 952
Query: 214 GSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQ 273
C G +C NGG C + +CDC+ + + G C +E + V G
Sbjct: 953 RPGCPGHCSSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAV-----FEAGTS 1007
Query: 274 GKSKGKEEYIATFKGSEYFCYDLSQNPIQS----SSDEITLSFKTLQRNGLMLHTGKSA- 328
+E Y T S LS + I + S + I LSF T Q L+L S+
Sbjct: 1008 VTYMFQEPYPVTKNIS------LSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINSSSQ 1061
Query: 329 DYVNLAL-KNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQ 378
D+V + L KNG++ + +L + F + H +K+ R R+
Sbjct: 1062 DFVVVLLCKNGSLQVRYHLNKEETHVFTIDAD-NFANRRMHHLKINREGRE 1111
Score = 53.1 bits (126), Expect = 2e-06
Identities = 39/149 (26%), Positives = 72/149 (48%), Gaps = 19/149 (12%)
Query: 305 SDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKFN 363
S +I+ FKT +G+ L D++ L + + + ++ I++G+G E +V+ + N
Sbjct: 812 SADISFFFKTTALSGVFLENLGIKDFIRLEISSPSEITFAIDVGNGPVELVVQSPS-LLN 870
Query: 364 DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQED-YTMLGSDDFFYVGGSPST 422
DN WH V+ RNL++ S + VD + +T T E+ + L + +VGG+ S
Sbjct: 871 DNQWHYVRAERNLKETS--------LQVDNLPRSTRETSEEGHFRLQLNSQLFVGGTSSR 922
Query: 423 ADLPGSPVSNNFMGCLKEVVYKNNDVRLE 451
F+GC++ + + LE
Sbjct: 923 --------QKGFLGCIRSLHLNGQKMDLE 943
Score = 52.4 bits (124), Expect = 3e-06
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 74/385 (19%)
Query: 736 HTE-AEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 794
H E + D+S F++ G+ + D +RLE+ + ++T +D G
Sbjct: 808 HAEFSADISFFFKTTALSGVFLENLG--IKDFIRLEISSPS-EITFAIDV-------GNG 857
Query: 795 PETLFAGYN--LNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD-HTRLEFHN-IETG 850
P L LNDN+WH VR R K L VD+ T + + + H RL+ ++ + G
Sbjct: 858 PVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVG 917
Query: 851 IITERRYLSSVPSNFIGHLQSLTFNGM-----------------------AYIDLCKNG- 886
+ R+ F+G ++SL NG +Y +C NG
Sbjct: 918 GTSSRQ------KGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGG 971
Query: 887 ------------------DIDYC--ELNARFGFRNIIAD------PVTFKTKSSYVALAT 920
+ +C E++A F + PVT S A+ T
Sbjct: 972 KCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYT 1031
Query: 921 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYVFDLGNGANLIKGSS 979
A + ++ F TT L+L+ + DF+VV L K G L + L +
Sbjct: 1032 DSAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHLNKEETHVFTID 1091
Query: 980 NKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGAR-NLDLKSDLYIGGVAKETYKS 1038
+ + H++ I+R+ L T+++D ++ + L +G V +
Sbjct: 1092 ADNFANRRMHHLKINREGREL-TIQMDQQLRLSYNFSPEVEFRVIRSLTLGKVTENLGLD 1150
Query: 1039 LPKLVHAKEGFQGCLASVDLNGRLP 1063
GF GC++SV N P
Sbjct: 1151 SEVAKANAMGFAGCMSSVQYNHIAP 1175
Score = 51.2 bits (121), Expect = 7e-06
Identities = 56/239 (23%), Positives = 93/239 (38%), Gaps = 38/239 (15%)
Query: 31 LEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRL 89
+ F + G + P +SFQ +T + GL+L + EG L + GG L
Sbjct: 368 ITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTLL--LSLEGGIL 425
Query: 90 QLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQ------VEAKWVEVKSK 143
+L A +L + +NDG WHSV I + TL +D ++ WV++ S
Sbjct: 426 RLVIQKMTERVAEILTGSNLNDGLWHSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSG 485
Query: 144 RRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNS--SQVLPVDSGE 201
+ + GG P L + + + F+G +R + +++ ++ V G
Sbjct: 486 -------NSYYFGGCPDNLTDS------QCLNPIKAFQGCMRLIFIDNQPKDLISVQQGS 532
Query: 202 VKLDDEPPNSGGGSP-----CEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
+ G S C + C +GG CS C+CS T + G C
Sbjct: 533 L---------GNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATC 582
Score = 46.2 bits (108), Expect = 2e-04
Identities = 37/163 (22%), Positives = 70/163 (42%), Gaps = 19/163 (11%)
Query: 1146 STRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES-- 1203
ST D +++ F ++Q + VL + G D++ L + +G++ + N+G + S
Sbjct: 199 STLKDVISLKFKSMQGDGVLFHGEGQRG--DHITLELQKGRLALHLNLGDSKARLSSSLP 256
Query: 1204 ----NAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG-KE 1258
++++D +H V R G VD + + + + + GG
Sbjct: 257 SATLGSLLDDQHWHSVLIERVGKQVNFTVDKHT--QHFRTKGETDALDIDYELSFGGIPV 314
Query: 1259 QGQP-------FQGQLSGLYYNGLKVLNMAAENDANIAIVGNV 1294
G+P F G + LYYNG+ ++++A I GNV
Sbjct: 315 PGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQI-YTGNV 356
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 127 bits (318), Expect = 1e-28
Identities = 180/815 (22%), Positives = 334/815 (40%), Gaps = 134/815 (16%)
Query: 294 YDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINLGSGAF 351
Y + + + ++ +I + F T NGL+L+ G + D++++ L G V ++ +LGSG
Sbjct: 2315 YSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPI 2374
Query: 352 EALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSD 411
L + ++N+ W+ + RN +Q V +D T+ T++ T S
Sbjct: 2375 TLLTDR---RYNNGTWYKIAFQRNRKQG-------VLAVIDAYNTSNKETKQGETPGASS 2424
Query: 412 DF-------FYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMK 464
D YVGG P + + + +F+GC+K LE+SR D
Sbjct: 2425 DLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKN---------LEISR--STFDLLRN 2473
Query: 465 IHGVVAFKCENVATLDPITFET--PESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHG 522
+GV L+PI + +I LP + F TT +G+IL + G
Sbjct: 2474 SYGV-----RKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALG 2528
Query: 523 ---KPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK----VNDGEW 575
+ R ++ H V FF++ ++ G++ + ++ G GT KALL +DG+
Sbjct: 2529 GDVEKRGDREEAH-----VPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQA 2583
Query: 576 YHVDFQRDGRSGTISV---NTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVW 632
+ + R+ R T+ + N + ES +++ + LY+GG+PE +
Sbjct: 2584 HSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSN-LYVGGIPEGEG--------- 2633
Query: 633 TALLNY--GYVGCIRDLFIDGQSKDIRQMAEVQST------AGVKPSCSKETA-KPCLSN 683
T+LL + GCI++L + + D + +P + + L
Sbjct: 2634 TSLLTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPE 2693
Query: 684 PCKNNGMCR-DGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDV 742
P C D YV G G + + +L ++ S K V
Sbjct: 2694 PRAFPEQCVVDAALEYV---PGAHQFGLT-QNSHFILPFNQSAVRK----------KLSV 2739
Query: 743 SLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY 802
L R+ + G++ ++ AD L+L GR+ +L KG +
Sbjct: 2740 ELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDL---------GKGRTKVSHPA 2790
Query: 803 NLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVP 862
L+D +WHTV+ + +TVD +++ + GD T L+ + YL +P
Sbjct: 2791 LLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGL--------FYLGGLP 2842
Query: 863 SNF----IGHLQ--------SLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFK 910
S + IG++ +T N L K+ + +N + +A T+
Sbjct: 2843 SQYQARKIGNITHSIPACIGDVTVNSK---QLDKDSPVSAFTVNRCYA----VAQEGTYF 2895
Query: 911 TKSSYVALAT--LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDL 968
S Y AL + + +++ +F+T+S +G++L S D I +ELV G + +F +
Sbjct: 2896 DGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKV--LFHV 2953
Query: 969 GNGANLIKGS----SNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQIT-AGARNLDLK 1023
NGA I + + L D +WH + ++ + + + + + ++D
Sbjct: 2954 NNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTN 3013
Query: 1024 SDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDL 1058
+ +Y+GG + K + ++ F+GCL + L
Sbjct: 3014 NPIYVGGYPAGVKQ---KCLRSQTSFRGCLRKLAL 3045
Score = 122 bits (305), Expect = 3e-27
Identities = 223/1042 (21%), Positives = 399/1042 (38%), Gaps = 217/1042 (20%)
Query: 293 CYDLSQNPIQSSS-DEITLSFKTLQRNGLMLHTGKS--ADYVNLALKNGAVSLVINLGSG 349
C Q I S++ + +TL+ KT + + L+ + G S +D++ + ++ G V+ + +LGSG
Sbjct: 2126 CIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSG 2185
Query: 350 AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTM-- 407
+ +E + +DN WH + V R IG V + T ++ T
Sbjct: 2186 STR--LEFPDFPIDDNRWHSIHVAR----FGNIGSLSVKEMSSNQKSPTKTSKSPGTANV 2239
Query: 408 --LGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKI 465
+ + +VGG + +F GCL E + L + + ++G K
Sbjct: 2240 LDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGL-WNYIEREG----KC 2294
Query: 466 HGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGS-ISFDFRTTEPNGLILF--SHG 522
G C + + +F S S+ + + T + I F T PNGL+L+ S+G
Sbjct: 2295 RG-----CFGSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYG 2349
Query: 523 KPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQR 582
DF +IE+ G + ++ D+GSG I + ++ N+G WY + FQR
Sbjct: 2350 TK--------------DFLSIELFRGRVKVMTDLGSGPITLLTD-RRYNNGTWYKIAFQR 2394
Query: 583 DGRSGTISV-------NTLRTPYTAPGESEILD-LD-DELYLGGLPENKAGLVFPTEVWT 633
+ + G ++V N PG S L+ LD D +Y+GGLP ++ V
Sbjct: 2395 NRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRV-------VRR 2447
Query: 634 ALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRD 693
+ +VGCI++L I + D+ ++++ GV+ K CL P ++ +
Sbjct: 2448 GVTTKSFVGCIKNLEISRSTFDL-----LRNSYGVR--------KGCLLEPIRSVSFLKG 2494
Query: 694 GWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYG 753
G+ I+LP + + + F + + G
Sbjct: 2495 GY---------------------------------IELPPKSLSPESEWLVTFATTNSSG 2521
Query: 754 ILMATTSRD---SADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY---NLNDN 807
I++A D D + V L + +N G +D
Sbjct: 2522 IILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDG 2581
Query: 808 EWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE--------------TGIIT 853
+ H++ +VR + + + +D+ + ++ T +E I T ++T
Sbjct: 2582 QAHSISLVRNRRIITVQLDENNPVEMKLG---TLVESRTINVSNLYVGGIPEGEGTSLLT 2638
Query: 854 ERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGF------RNIIADPV 907
RR N I +L+ L FN + D+D C L+ R ++ +P
Sbjct: 2639 MRRSFHGCIKNLIFNLELLDFNSAVGHE---QVDLDTCWLSERPKLAPDAEDSKLLPEPR 2695
Query: 908 TFK--------------------TKSSYVALATLQAYTSMHLFFQ--FKTTSLDGLILYN 945
F T++S+ L Q+ L + +T + GLI Y
Sbjct: 2696 AFPEQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYM 2755
Query: 946 SGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1004
+ D+ V++L G LH++FDLG G K S L+D +WH V +
Sbjct: 2756 AHQNQADYAVLQLHGGRLHFMFDLGKGRT--KVSHPALLSDGKWHTVKTDY-VKRKGFIT 2812
Query: 1005 IDTKITTQIT--AGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRL 1062
+D + + +T LD++ Y+GG+ + Y++ K+ + C+ V +N +
Sbjct: 2813 VDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQ-YQA-RKIGNITHSIPACIGDVTVNSK- 2869
Query: 1063 PDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDP 1122
Q+++ + T C + G +
Sbjct: 2870 ------------QLDKDSPVSAFTVNR-------------------CYAVAQEGTYFDGS 2898
Query: 1123 GTTYIFSKGGGQITYKWPPNDRPSTRAD-RLAIGFSTVQKEAVLVRVDSSSGLGDYLELH 1181
G + +G YK ++D + + F T + VL+ + S+ D + L
Sbjct: 2899 GYAALVKEG-----YK--------VQSDVNITLEFRTSSQNGVLLGI--STAKVDAIGLE 2943
Query: 1182 IHQGKIGVKFNVGTDDI--AIEESNA-IINDGKYHVVRFTRSGGNATLQVDSWPVIERYP 1238
+ GK+ N G I A E A ++ DGK+H ++ +S TL VD V P
Sbjct: 2944 LVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESP 3003
Query: 1239 AGRQLTIFNSQATIIIGGKEQG 1260
Q T ++ I +GG G
Sbjct: 3004 -HTQSTSVDTNNPIYVGGYPAG 3024
Score = 67.4 bits (163), Expect = 1e-10
Identities = 76/340 (22%), Positives = 138/340 (40%), Gaps = 47/340 (13%)
Query: 289 SEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINL 346
+ +F +Q+ ++ + LS +T +GL+ + ADY L L G + + +L
Sbjct: 2721 NSHFILPFNQSAVRKKLS-VELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDL 2779
Query: 347 GSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYT 406
G G + + +D WH VK R+ I+VDG + D T
Sbjct: 2780 GKGRTKVSHPAL---LSDGKWHTVKTDYVKRKGF--------ITVDGRESPMVTVVGDGT 2828
Query: 407 MLGSDDFFYVGGSPSTADLPG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKI 465
ML + FY+GG PS ++++ C+ +V +KQ D +
Sbjct: 2829 MLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVN-----------SKQLDKDSPV 2877
Query: 466 HGVVAFKCENVATLDPITFETPESFISLPK--WNAKKTGSISFDFRTTEPNGLILFSHGK 523
+C VA T+ + +L K + + +I+ +FRT+ NG++L
Sbjct: 2878 SAFTVNRCYAVA--QEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLL----- 2930
Query: 524 PRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN---DGEWYHVDF 580
KVD +E++DG + ++ G+G I K DG+W+ +
Sbjct: 2931 --------GISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQA 2982
Query: 581 QRDGRSGTISVNTLRTPYTAP-GESEILDLDDELYLGGLP 619
+ T+ V+ +P +S +D ++ +Y+GG P
Sbjct: 2983 NKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
Score = 55.8 bits (133), Expect = 3e-07
Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 20/192 (10%)
Query: 286 FKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS-ADYVNLALKNGAVSLVI 344
F GS Y +QS + ITL F+T +NG++L + D + L L +G V +
Sbjct: 2895 FDGSGYAALVKEGYKVQSDVN-ITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKVLFHV 2953
Query: 345 NLGSGAFEALVEPVNGK-FNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQE 403
N G+G A EP D WH ++ ++ + +T+ VDG
Sbjct: 2954 NNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHR--------ITLIVDGNAVGAESPHT 3005
Query: 404 DYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEV-VYKNNDVR-LELSRLAKQGDP 461
T + +++ YVGG P+ +F GCL+++ + K+ V+ + SR
Sbjct: 3006 QSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIKSPQVQSFDFSR------- 3058
Query: 462 KMKIHGVVAFKC 473
++HGV C
Sbjct: 3059 AFELHGVFLHSC 3070
Score = 42.4 bits (98), Expect = 0.003
Identities = 33/108 (30%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query: 60 TRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRI 119
T S GL+LY G DFL + L RG R+++ + P TLL D N+G W+ +
Sbjct: 2335 TFSPNGLLLYLGSYGTKDFLSIELFRG-RVKVMTDLGSG-PITLLTDRRYNNGTWYKIAF 2392
Query: 120 RRQFRNTTLFI------DQVEAKWVEVKSKRRDMTVF--SGLFVGGLP 159
+R + L + E K E D+ ++VGGLP
Sbjct: 2393 QRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLP 2440
Score = 38.9 bits (89), Expect = 0.037
Identities = 31/148 (20%), Positives = 65/148 (43%), Gaps = 17/148 (11%)
Query: 1146 STRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNA 1205
ST + L + T + + +L + SS+ D+L + + +G++ +++G+ +E +
Sbjct: 2136 STNYNTLTLNVKTQEPDNLLFYLGSSTA-SDFLAVEMRRGRVAFLWDLGSGSTRLEFPDF 2194
Query: 1206 IINDGKYHVVRFTRSGGNATLQVDSWPVIERYP--------AGRQLTIFNSQATII--IG 1255
I+D ++H + R G +L V ++ P L + NS + +G
Sbjct: 2195 PIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLG 2254
Query: 1256 GKEQGQP------FQGQLSGLYYNGLKV 1277
G+ + P F+G L + NG +
Sbjct: 2255 GQIKKSPAVKVTHFKGCLGEAFLNGKSI 2282
Score = 38.5 bits (88), Expect = 0.048
Identities = 32/160 (20%), Positives = 69/160 (43%), Gaps = 18/160 (11%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATL 103
P+ ++ + ++ +KT+ L+ Y DFL + + RG R+ + +
Sbjct: 2132 PQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRG-RVAFLWDLGSGSTRLE 2190
Query: 104 LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR--------DMTVFSGLFV 155
D P++D WHS+ + R +L + ++ + + D+ + +FV
Sbjct: 2191 FPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFV 2250
Query: 156 GGLPPEL-RAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
GGL ++ ++ A+K+T FKG + + +N +
Sbjct: 2251 GGLGGQIKKSPAVKVT--------HFKGCLGEAFLNGKSI 2282
>gi|239743797 PREDICTED: similar to cell recognition molecule CASPR3
[Homo sapiens]
Length = 944
Score = 114 bits (286), Expect = 5e-25
Identities = 101/372 (27%), Positives = 169/372 (45%), Gaps = 47/372 (12%)
Query: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVEL-VKGYLHYVF 966
+F T++SY+ + + F FKTT G+ + N G DFI +EL + + F
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 587
Query: 967 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1024
D+GNG + S P NDNQWH+V R+ ++L ++ K+ G L L S
Sbjct: 588 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 647
Query: 1025 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1084
L+IGG A + GF GC+ S+ LNG DL A G +E GC G
Sbjct: 648 QLFIGGTATR-----------QRGFLGCIRSLQLNGVALDLEERATVMPG-VEPGCAGHC 695
Query: 1085 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPN-- 1142
+T C N G C ++ G +CDC+ +++ GP C++ + Y + G +TY + +
Sbjct: 696 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFAT--GSSMTYHFQEHYT 752
Query: 1143 --------------DRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI-HQGKI 1187
D TR + + + F T + ++L+ V SS +YL + + + G +
Sbjct: 753 LSENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSLLLYV--SSFYEEYLSVILANNGSL 809
Query: 1188 GVKFNV----GTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQL 1243
+++ + D + N + DG+ H V+ R A + V+ ++
Sbjct: 810 QIRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINRE--EAVVMVEVNQSAKKQVILSSG 865
Query: 1244 TIFNSQATIIIG 1255
T FN+ ++I+G
Sbjct: 866 TEFNAVKSLILG 877
Score = 90.1 bits (222), Expect = 1e-17
Identities = 82/355 (23%), Positives = 150/355 (42%), Gaps = 61/355 (17%)
Query: 483 TFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFA 542
+F T S++ P ++ + T + F F+TT +G+ + + G DF
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI--------------TDFIR 574
Query: 543 IEM-LDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTISVNTL-RTPYT 599
IE+ + D+G+G ++ ND +W+HV +R+ + ++ V+ L +
Sbjct: 575 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQP 634
Query: 600 APGESEI-LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQ 658
AP + + L L+ +L++GG TA G++GCIR L ++G + D+ +
Sbjct: 635 APADGHVRLQLNSQLFIGG---------------TATRQRGFLGCIRSLQLNGVALDLEE 679
Query: 659 MAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATV 718
A V GV+P C+ + + C+N G CR+ CDC+ + Y G C E +
Sbjct: 680 RATVMP--GVEPGCAGHCST--YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISA 735
Query: 719 LSYDGSMFM------------KIQLPVVMHTEA----EDVSLRFRSQRAYGILMATTSRD 762
GS L +H + E ++L FR+ R +L+ +S
Sbjct: 736 YFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVSSFY 795
Query: 763 SADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETL-FAGYNLNDNEWHTVRVVR 816
+ + G +++ LD + P+ F N+ D + H V++ R
Sbjct: 796 EEYLSVILANNGSLQIRYKLD-------RHQNPDAFTFDFKNMADGQLHQVKINR 843
Score = 73.6 bits (179), Expect = 1e-12
Identities = 73/304 (24%), Positives = 125/304 (41%), Gaps = 34/304 (11%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 533 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 590
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGLF 154
T+ + TP ND WH VR R + +L +DQ+ K + + + S LF
Sbjct: 591 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLF 650
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
+GG + R+R F G IR +++N + + V EP +G
Sbjct: 651 IGG--------------TATRQR-GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHC 695
Query: 215 SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQG 274
S G +C NGG C CDC+ + + G CS E + A+ G
Sbjct: 696 ST-------YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEIS-----AYFATGSSM 743
Query: 275 KSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-SADYVNL 333
+E Y T + + + + ITLSF+T + L+L+ +Y+++
Sbjct: 744 TYHFQEHY--TLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSV 801
Query: 334 ALKN 337
L N
Sbjct: 802 ILAN 805
Score = 50.1 bits (118), Expect = 2e-05
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 1048 GFQGCLASVDLNGRLPDLI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDG 1104
GFQGCL + + + D I AL ++ G + C C + G C Q WD
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDT 261
Query: 1105 FSCDCSMTSFSGPLCN 1120
FSCDC T ++G C+
Sbjct: 262 FSCDCLGTGYTGETCH 277
Score = 48.1 bits (113), Expect = 6e-05
Identities = 24/76 (31%), Positives = 40/76 (52%), Gaps = 3/76 (3%)
Query: 639 GYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWN 696
G+ GC+R + I ++ D + Q + S ++ T + CL + C++ G C W+
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CLPSYCEHGGECSQSWD 260
Query: 697 RYVCDCSGTGYLGRSC 712
+ CDC GTGY G +C
Sbjct: 261 TFSCDCLGTGYTGETC 276
Score = 47.4 bits (111), Expect = 1e-04
Identities = 78/317 (24%), Positives = 115/317 (36%), Gaps = 82/317 (25%)
Query: 741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 800
DV F++ + G+ M D +R+EL A ++T + D C + T F
Sbjct: 549 DVCFFFKTTVSSGVFMENLG--ITDFIRIELRAP-TEVTFSFDVGNGPCEVTVQSPTPF- 604
Query: 801 GYNLNDNEWHTVRVVRRGKSLKLTVDD-QQAMTGQMAGDHTRLEFHN--IETGIITERRY 857
NDN+WH VR R K L VD Q M A H RL+ ++ G T +R
Sbjct: 605 ----NDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQR- 659
Query: 858 LSSVPSNFIGHLQSLTFNGMA-----------------------YIDLCKNGDIDYCELN 894
F+G ++SL NG+A Y LC+NG
Sbjct: 660 ------GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHCSTYGHLCRNGG------R 707
Query: 895 ARFGFRNIIAD--------PVTFKTKSSYVALATLQAY----------------TSMH-- 928
R R + D P S+Y A + Y +S+H
Sbjct: 708 CREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRD 767
Query: 929 -------LFFQFKTTSLDGLILYNSGDGNDFIVVELV-KGYLHYVFDLGNGANLIKGSSN 980
+ F+TT L+LY S +++ V L G L + L N + +
Sbjct: 768 VTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFD 827
Query: 981 -KPLNDNQWHNVMISRD 996
K + D Q H V I+R+
Sbjct: 828 FKNMADGQLHQVKINRE 844
Score = 43.9 bits (102), Expect = 0.001
Identities = 58/271 (21%), Positives = 103/271 (38%), Gaps = 48/271 (17%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCS--RTGFRGKDCSQEDNNVE 263
+E S GGS +A + C G + +D Q C+C R +
Sbjct: 439 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDAGRNEWTSDTIVLSQKEHL 492
Query: 264 GLAHLMMGDQGKSKGKEEYIA---------TFKGSEYFCYDLSQNPIQSSSDEITLS--- 311
+ ++M D G+ + +Y +F S F + S + E+T
Sbjct: 493 PVTQIVMTDAGQPHSEADYTLGPLLCRGDKSFWNSASFNTETSYLHFPAFHGELTADVCF 552
Query: 312 -FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKFNDNAWHD 369
FKT +G+ + D++ + L+ V+ ++G+G E V+ FNDN WH
Sbjct: 553 FFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFNDNQWHH 611
Query: 370 VKVTRNLR----QHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
V+ RN++ Q + M DG + L + ++GG+ +
Sbjct: 612 VRAERNVKGASLQVDQLPQKMQPAPADG-----------HVRLQLNSQLFIGGTATR--- 657
Query: 426 PGSPVSNNFMGCLKEVVYKNNDVRLELSRLA 456
F+GC++ + + N V L+L A
Sbjct: 658 -----QRGFLGCIRSL--QLNGVALDLEERA 681
Score = 32.0 bits (71), Expect = 4.5
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 228 CLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
C +GG CS D CDC TG+ G+ C
Sbjct: 249 CEHGGECSQSWDTFSCDCLGTGYTGETC 276
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 114 bits (286), Expect = 5e-25
Identities = 95/343 (27%), Positives = 155/343 (45%), Gaps = 39/343 (11%)
Query: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG-YLHYVF 966
+F T++SY+ T S + F FKTT+ G+ L N G DFI +EL + + F
Sbjct: 723 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 781
Query: 967 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1024
D+GNG I S NDNQWH+V + R+ ++L ++ K G L L S
Sbjct: 782 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNS 841
Query: 1025 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1084
L++GG A + GF GC+ S+ LNG DL A +++ GC G
Sbjct: 842 QLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDLEERAQV-TPEVQPGCRGHC 889
Query: 1085 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDR 1144
++ + C N G C ++ GF CDC+ ++++GP C++ + Y S G + Y + N
Sbjct: 890 SSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGS--GSSVIYNFQENYL 946
Query: 1145 PSTRA---------------DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQG---K 1186
S + + + F T + ++L+ V SS +YL + I + +
Sbjct: 947 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFV--SSFYKEYLSVIIAKNGSLQ 1004
Query: 1187 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1229
I K N + + + DG+ H + R G +++D
Sbjct: 1005 IRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1047
Score = 108 bits (270), Expect = 4e-23
Identities = 114/455 (25%), Positives = 189/455 (41%), Gaps = 93/455 (20%)
Query: 712 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 770
C + V+ DG + + + +D+ SL+F++ ++ GIL+ + D + L+
Sbjct: 152 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 210
Query: 771 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 830
L R+ L +N ++ S+ TL G L+D WH+V + R GK + TVD+ +
Sbjct: 211 LRRARLFLLINSGEAKLPSTSTLVNLTL--GSLLDDQHWHSVLIQRLGKQVNFTVDEHRH 268
Query: 831 MTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDY 890
H R EF+ L +L + G
Sbjct: 269 HF------HARGEFN-----------------------LMNLDYEG-------------- 285
Query: 891 CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 950
N F + PVTF + SY+AL + FQF+T + GL+L++
Sbjct: 286 ---NVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE---- 338
Query: 951 DFIVVELVKG-YLHYVFDLGNGANLIKG-------SSNKPLNDNQWHNVMISRDTSNLHT 1002
++L+ G L ++ D +NL + ++ LND QWH+V +S ++L +
Sbjct: 339 ----LQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHL-S 393
Query: 1003 VKIDTKITTQITA-GARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGR 1061
V +D ++ + G + Y GG +++ S K GFQGC+ + ++G+
Sbjct: 394 VAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMRLISISGK 451
Query: 1062 LPDLISDAL-----FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSG 1116
+ DLIS F + QI+ C G S C + C + G C Q W F C+C+ T + G
Sbjct: 452 VVDLISVQQGSLGNFSDLQID-SC-GISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRG 509
Query: 1117 PLC----------------NDPGTTYIFSKGGGQI 1135
C N G YI S G G +
Sbjct: 510 ATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSGPL 544
Score = 97.4 bits (241), Expect = 9e-20
Identities = 90/394 (22%), Positives = 165/394 (41%), Gaps = 69/394 (17%)
Query: 464 KIHGVVAFK-----CENVATL-DPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLI 517
++H A+K C+ + + +F+T S++ P ++ + + +SF F+TT +G+
Sbjct: 698 RLHSEAAYKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVF 757
Query: 518 LFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLL-LDMGSGTIKIKALLKK-VNDGEW 575
L + G DF IE+ + D+G+G +I ND +W
Sbjct: 758 LENLGI--------------ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQW 803
Query: 576 YHVDFQRDGRSGTISVNTLRTPYTAPGESE---ILDLDDELYLGGLPENKAGLVFPTEVW 632
+HV +R+ + ++ V+ L TP T P ++ +L L+ +L++GG
Sbjct: 804 HHVRVERNMKEASLQVDQL-TPKTQPAPADGHVLLQLNSQLFVGG--------------- 847
Query: 633 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 692
TA G++GCIR L ++G + D+ + A+V T V+P C + C+N G CR
Sbjct: 848 TATRQRGFLGCIRSLQLNGMTLDLEERAQV--TPEVQPGCRGHCSS--YGKLCRNGGKCR 903
Query: 693 DGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFM----------------KIQLPVVMH 736
+ + CDC+ + Y G C E + GS + M
Sbjct: 904 ERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMK 963
Query: 737 TEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPE 796
E + FR+ R +L+ +S + G ++ IR N + P+
Sbjct: 964 LSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQ-------IRYKLNKYQEPD 1016
Query: 797 TL-FAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQ 829
+ F N+ D + H + + R + + +DD +
Sbjct: 1017 VVNFDFKNMADGQLHHIMINREEGVVFIEIDDNR 1050
Score = 79.3 bits (194), Expect = 2e-14
Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 50/262 (19%)
Query: 467 GVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRH 526
G V+F C ++ P+TF + S+++LP ++ ++ S +F FRT GL+LFS
Sbjct: 285 GNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE----- 338
Query: 527 QKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-------------VNDG 573
++++ G + L L G K+K+ L + +NDG
Sbjct: 339 ----------------LQLISGGILLFLSDG----KLKSNLYQPGKLPSDITAGVELNDG 378
Query: 574 EWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWT 633
+W+ V +++V+ E + Y GG P+ G + +
Sbjct: 379 QWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLG- 437
Query: 634 ALLNYGYVGCIRDLFIDGQSKDIR--QMAEVQSTAGVK-PSCSKETAKPCLSNPCKNNGM 690
G+ GC+R + I G+ D+ Q + + + ++ SC + CL N C++ G
Sbjct: 438 -----GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCG--ISDRCLPNYCEHGGE 490
Query: 691 CRDGWNRYVCDCSGTGYLGRSC 712
C W+ + C+C+ TGY G +C
Sbjct: 491 CSQSWSTFHCNCTNTGYRGATC 512
Score = 72.8 bits (177), Expect = 2e-12
Identities = 78/346 (22%), Positives = 141/346 (40%), Gaps = 43/346 (12%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++SF KT ++ G+ L ++ G DF+ + L + SF +
Sbjct: 727 EASYLHFPTFHGELSADVSFFFKTTASSGVFL--ENLGIADFIRIELRSPTVVTFSFDVG 784
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRD-MTVFSGLF 154
++ + T ND WH VR+ R + +L +DQ+ K + + + S LF
Sbjct: 785 NGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLF 844
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
VGG + R+R F G IR +++N + + +V + +P
Sbjct: 845 VGG--------------TATRQR-GFLGCIRSLQLNGMTLDLEERAQVTPEVQP------ 883
Query: 215 SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEG----LAHLMM 270
C G +C NGG C CDC+ + + G CS E + G + +
Sbjct: 884 -GCRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQ 942
Query: 271 GDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-SAD 329
+ SK + A+F G ++ S + I SF+T + L+L +
Sbjct: 943 ENYLLSKNSSSHAASFHGD-----------MKLSREMIKFSFRTTRTPSLLLFVSSFYKE 991
Query: 330 YVNLAL-KNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTR 374
Y+++ + KNG++ + L +V D H + + R
Sbjct: 992 YLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNMADGQLHHIMINR 1037
Score = 62.0 bits (149), Expect = 4e-09
Identities = 91/382 (23%), Positives = 152/382 (39%), Gaps = 78/382 (20%)
Query: 741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLF- 799
DVS F++ + G+ + AD +R+EL + V + + + GP +
Sbjct: 743 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV--------VTFSFDVGNGPFEISV 792
Query: 800 -AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD-HTRLEFHN--IETGIITER 855
+ + NDN+WH VRV R K L VD T D H L+ ++ G T +
Sbjct: 793 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQ 852
Query: 856 RYLSSVPSNFIGHLQSLTFNGM-----------------------AYIDLCKNGDI---- 888
R F+G ++SL NGM +Y LC+NG
Sbjct: 853 R-------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRER 905
Query: 889 ---------------DYC--ELNARFG-----FRNIIADPVTFKTKSSYVALATLQAYTS 926
+C E++A FG N + + K SS+ A S
Sbjct: 906 PIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 965
Query: 927 MHLF-FQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYVFDLGNGANL-IKGSSNKPL 983
+ F F+TT L+L+ S +++ V + K G L + L + K +
Sbjct: 966 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNM 1025
Query: 984 NDNQWHNVMISRDTSNLHTVKIDTKITTQI--TAGARNLDLKSDLYIGGVAKETYKSLPK 1041
D Q H++MI+R+ + ++ID Q+ ++G +KS L +G + + +
Sbjct: 1026 ADGQLHHIMINRE-EGVVFIEIDDNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDT 1083
Query: 1042 LVHAKEGFQGCLASVDLNGRLP 1063
+ +GF GCL++V L+ P
Sbjct: 1084 ALAGAQGFTGCLSAVQLSHVAP 1105
Score = 55.5 bits (132), Expect = 4e-07
Identities = 41/155 (26%), Positives = 76/155 (49%), Gaps = 21/155 (13%)
Query: 305 SDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAV-SLVINLGSGAFEALVEPVNGKFN 363
S +++ FKT +G+ L AD++ + L++ V + ++G+G FE V+ FN
Sbjct: 741 SADVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT-HFN 799
Query: 364 DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQED-YTMLGSDDFFYVGGSPST 422
DN WH V+V RN+++ S + VD + T D + +L + +VGG+ +
Sbjct: 800 DNQWHHVRVERNMKEAS--------LQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATR 851
Query: 423 ADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 457
F+GC++ + + N + L+L A+
Sbjct: 852 --------QRGFLGCIRSL--QLNGMTLDLEERAQ 876
Score = 52.0 bits (123), Expect = 4e-06
Identities = 50/210 (23%), Positives = 91/210 (43%), Gaps = 20/210 (9%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
E +FQ +T + GL+L+ + + + L L+ G+L+ + P+ + A +N
Sbjct: 318 EVSATFQFRTWNKAGLLLFSELQLISGGILLFLS-DGKLKSNLYQPGKLPSDITAGVELN 376
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALK 168
DG WHSV + + + ++ +D A + + ++SG + GG P + + K
Sbjct: 377 DGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQ---IYSGGTYYFGGCPDKSFGSKCK 433
Query: 169 LTLASVREREPFKGWIRDVRVNSSQV--LPVDSGEV-KLDDEPPNSGGGSPCEAGEEGEG 225
L F+G +R + ++ V + V G + D +S C +
Sbjct: 434 SPLGG------FQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDS-----CGISDRCLP 482
Query: 226 GVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
C +GG CS C+C+ TG+RG C
Sbjct: 483 NYCEHGGECSQSWSTFHCNCTNTGYRGATC 512
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 283 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-TGKSADYVNLALKNGAVS 341
+ G Y Q + D I+L FKT+Q +G++LH G + D++ L L+ +
Sbjct: 158 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 217
Query: 342 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTR 374
L+IN G + VN +D WH V + R
Sbjct: 218 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQR 254
Score = 37.0 bits (84), Expect = 0.14
Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 19/115 (16%)
Query: 504 ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKI 563
IS F+T + +G++L G D +++ L+LL++ G +
Sbjct: 183 ISLKFKTMQSDGILLHREGP-------------NGDHITLQLRRARLFLLINSGEAKLPS 229
Query: 564 KALLKKV------NDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDE 612
+ L + +D W+ V QR G+ +V+ R + A GE +++LD E
Sbjct: 230 TSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYE 284
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 105 bits (263), Expect = 2e-22
Identities = 168/776 (21%), Positives = 292/776 (37%), Gaps = 139/776 (17%)
Query: 538 VDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTP 597
+DF AIEM G + L D+GSG +++ ++D WY + R GR+GTISV L P
Sbjct: 2192 IDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2251
Query: 598 Y----------TAPGESEILDLDDE--LYLGGLPENKAGLVFPTEVWTALLNYGYVGCIR 645
T+P ILD+D L++GGL K V T + GC+
Sbjct: 2252 KASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT-GKLKKADAVRVIT------FTGCMG 2304
Query: 646 DLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGT 705
+ + D + + E + K C +P V D GT
Sbjct: 2305 ETYFDNKPIGLWNFREKEGDC-----------KGCTVSP-------------QVEDSEGT 2340
Query: 706 GYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSAD 765
+ +DG + + P+ + V +FR+ + +LM +RD D
Sbjct: 2341 -------------IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRD 2387
Query: 766 TLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 825
+ +EL G +K++ +L G ++ + N ND +W + + R K +++
Sbjct: 2388 FMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 826 DD-----QQAMTGQMAGDHTRLEFHNIET----GIITERRYLSSVP-SNFIGHLQSLTFN 875
D ++ + +G++ L+ + G+ T R V + G L+ + +
Sbjct: 2439 VDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIEIS 2498
Query: 876 GMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKT 935
Y L DY + N+ V+F K +V L+ + + F T
Sbjct: 2499 RTPYNIL---SSPDYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEINLSFST 2552
Query: 936 TSLDGLILYNSG------------DGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKP- 982
+ G+IL SG G + V+ L +G L L GA ++ +P
Sbjct: 2553 KNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKIVIRPE 2610
Query: 983 ---LNDNQWHNVMISRDTSNLHTVKID-TKITTQITAGARNLDLKSDLYIGGVAKETYKS 1038
+D + H+V + R T + TV++D + Q + +++K L++GG E
Sbjct: 2611 PNLFHDGREHSVHVER-TRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPEFQ-- 2666
Query: 1039 LPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVC 1098
P + F+GC+ ++ +N D F N I R C ED + +
Sbjct: 2667 -PSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAAPAEIV 2724
Query: 1099 LQ----QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAI 1154
+Q F + + I SK G +R +AI
Sbjct: 2725 IQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFG------------LSRNSHIAI 2772
Query: 1155 GFSTVQKEAVL-----VRVDSSSGL---------GDYLELHIHQGKIGVKFNVGTDDIAI 1200
F + + L VR ++ SGL D+ + + G +++G+ D
Sbjct: 2773 AFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHT 2832
Query: 1201 EESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG 1256
INDG++H ++ RS L VD R + ++ I + + +GG
Sbjct: 2833 MIPTK-INDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGG 2885
Score = 75.5 bits (184), Expect = 4e-13
Identities = 91/392 (23%), Positives = 163/392 (41%), Gaps = 53/392 (13%)
Query: 302 QSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVN 359
+ S + I ++ KT + L+ + G K D++ + ++ G VS + ++GSG VE +
Sbjct: 2164 KGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGV--GRVEYPD 2221
Query: 360 GKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDG----ILTTTGYTQED--YTMLGSDD- 412
+D+ W+ + +R +G + ++DG I+ +T ++ YT+L D
Sbjct: 2222 LTIDDSYWYRIVASR-----TGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDAN 2276
Query: 413 -FFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAF 471
+VGG + F GC+ E + N + L R K+GD K
Sbjct: 2277 AMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSPQVE 2335
Query: 472 KCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAK 531
E D + + +S P ++ F FRT + L+++ +
Sbjct: 2336 DSEGTIQFDGEGY----ALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLR----- 2386
Query: 532 HPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISV 591
DF ++E+ DGH+ + D+GSG + + + NDG+W R + IS+
Sbjct: 2387 -------DFMSVELTDGHIKVSYDLGSGMASVVS-NQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 592 NTLRT------PYTAPGESEILDL--DDELYLGGLPENKAGLVFPTEVWTALLNYGYVGC 643
+ T ++ G + LDL DD++Y GGLP + + + Y GC
Sbjct: 2439 VDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLR-------NLRPEVNLKKYSGC 2491
Query: 644 IRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKE 675
++D+ I +I + GV CS E
Sbjct: 2492 LKDIEISRTPYNILSSPDY---VGVTKGCSLE 2520
Score = 72.4 bits (176), Expect = 3e-12
Identities = 159/812 (19%), Positives = 300/812 (36%), Gaps = 117/812 (14%)
Query: 294 YDLSQNPIQ--SSSDEITLSFKTLQRNGLMLH--TGKSADYVNLALKNGAVSLVINLGSG 349
Y L PI+ + + F+T + L+++ T D++++ L +G + + +LGSG
Sbjct: 2348 YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSG 2407
Query: 350 AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLG 409
+ N ND W ++R +++ + I + + + + T+ L
Sbjct: 2408 MASVVS---NQNHNDGKWKSFTLSR-IQKQANISIVDIDTNQEENIATSSSGNNFGLDLK 2463
Query: 410 SDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV 469
+DD Y GG P+ +L + GCLK++ E+SR GV
Sbjct: 2464 ADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDI---------EISRTPYNILSSPDYVGVT 2514
Query: 470 -AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQK 528
ENV T ++F P F+ L I+ F T +G+IL G
Sbjct: 2515 KGCSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAPP 2570
Query: 529 DAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN---DGEWYHVDFQRDGR 585
K Q + ++ I + G L + L G+ T++ + + N DG + V +R
Sbjct: 2571 RRKRRQTGQA-YYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRG 2629
Query: 586 SGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYG-YVGCI 644
T+ V+ R + +++ +L++GG P P + L N + GCI
Sbjct: 2630 IFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAP--------PEFQPSPLRNIPPFEGCI 2680
Query: 645 RDLFIDGQSKDIRQM-----AEVQSTAGVKPSCSKETAKPC---------------LSNP 684
+L I+ D + A++ A K ++ A P P
Sbjct: 2681 WNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTP 2740
Query: 685 CKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSL 744
+G C + G+ G S + D + ++ + + + TEAE
Sbjct: 2741 VLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAES--- 2795
Query: 745 RFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNL 804
G+L + AD ++L G + +L G +
Sbjct: 2796 --------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GSGDTHTMIPTKI 2838
Query: 805 NDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSN 864
ND +WH ++++R + L VD T + + + Y+ +P N
Sbjct: 2839 NDGQWHKIKIMRSKQEGILYVDGASNRT---------ISPKKADILDVVGMLYVGGLPIN 2889
Query: 865 FIGH-LQSLTFNGMAYIDLCKNG--------DIDYCELNARFGFRNIIADPVTFKTKSSY 915
+ + +T++ ID C D++ + G A T+ + +
Sbjct: 2890 YTTRRIGPVTYS----IDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGF 2945
Query: 916 V-ALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANL 974
A+ + + + F+F+TT+ G++L S D + +E++ L + D G G
Sbjct: 2946 AKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAGRFT 3005
Query: 975 IKGSSNKP--LNDNQWHNVMISRDTSNLHTVKIDTKITTQI-TAGARNLDLKSDLYIGGV 1031
+ P L D QWH V ++ + ++ Q + + D +++GG
Sbjct: 3006 AVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGF 3065
Query: 1032 AKETYK-----SLPKLVHAKEGFQGCLASVDL 1058
+ + S+P F+GC+ S+ L
Sbjct: 3066 PDDLKQFGLTTSIP--------FRGCIRSLKL 3089
Score = 66.2 bits (160), Expect = 2e-10
Identities = 87/375 (23%), Positives = 147/375 (39%), Gaps = 54/375 (14%)
Query: 308 ITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 365
I L +T +GL+ + + AD+ + L+NG +LGSG ++ K ND
Sbjct: 2785 IELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPT---KINDG 2841
Query: 366 AWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
WH +K+ R+ ++ GI + VDG T + + +L YVGG P
Sbjct: 2842 QWHKIKIMRSKQE--GI------LYVDGASNRT-ISPKKADILDVVGMLYVGGLPINYTT 2892
Query: 426 PG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITF 484
PV+ + GC++ + LE P H F T F
Sbjct: 2893 RRIGPVTYSIDGCVRNLHMAEAPADLE--------QPTSSFHVGTCFANAQRGTY----F 2940
Query: 485 ETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIE 544
+ ++ + + F+FRTT G++L + K+D IE
Sbjct: 2941 DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQ-------------KMDGMGIE 2987
Query: 545 MLDGHLYLLLDMGSG---TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAP 601
M+D L +D G+G + + + DG+W+ V + ++V+ + +P
Sbjct: 2988 MIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSP 3047
Query: 602 G-ESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDL-FIDGQSKDIR-Q 658
S D +D +++GG P++ T + + GCIR L G K +
Sbjct: 3048 NPASTSADTNDPVFVGGFPDDLKQFGLTTSI-------PFRGCIRSLKLTKGTGKPLEVN 3100
Query: 659 MAEVQSTAGVKP-SC 672
A+ GV+P SC
Sbjct: 3101 FAKALELRGVQPVSC 3115
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 3/106 (2%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+ +++T + GL+ Y DF + L R G S+ + + T++ T +NDG
Sbjct: 2785 IELEVRTEAESGLLFYMARINHADFATVQL-RNGLPYFSYDLGSGDTHTMIP-TKINDGQ 2842
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP 159
WH ++I R + L++D + + K K + V L+VGGLP
Sbjct: 2843 WHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVGMLYVGGLP 2887
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/303 (22%), Positives = 119/303 (39%), Gaps = 47/303 (15%)
Query: 934 KTTSLDGLILY-NSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVM 992
KT D L+ Y S DF+ +E+ KG + +++D+G+G ++ + ++D+ W+ ++
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 993 ISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGC 1052
SR N T R LD G A +P H+
Sbjct: 2234 ASRTGRN-------------GTISVRALD-------GPKA----SIVPSTHHSTSPPGYT 2269
Query: 1053 LASVDLN-----GRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSC 1107
+ VD N G L + A GC G E N+ + L +
Sbjct: 2270 ILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMG------ETYFDNKPIGLWNFREKEG 2323
Query: 1108 DCSMTSFSGPLCNDPGTTYIFSKGGGQIT--YKWPPNDRPSTRADRLAIGFSTVQKEAVL 1165
DC + S + + GT +G ++ +W PN + F T A+L
Sbjct: 2324 DCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPN------ISTVMFKFRTFSSSALL 2377
Query: 1166 VRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNAT 1225
+ + ++ L D++ + + G I V +++G+ +A SN NDGK+ +R A
Sbjct: 2378 MYL-ATRDLRDFMSVELTDGHIKVSYDLGS-GMASVVSNQNHNDGKWKSFTLSRIQKQAN 2435
Query: 1226 LQV 1228
+ +
Sbjct: 2436 ISI 2438
Score = 38.5 bits (88), Expect = 0.048
Identities = 34/149 (22%), Positives = 71/149 (47%), Gaps = 22/149 (14%)
Query: 52 SEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVND 111
S + F+ +T S+ L++Y DF+ + LT G +++S+ + A+++++ ND
Sbjct: 2362 STVMFKFRTFSSSALLMYLATRDLRDFMSVELT-DGHIKVSYDLGSGM-ASVVSNQNHND 2419
Query: 112 GAWHSV---RIRRQFRNTTLFIDQVEAKWVEVKSKRR----DMTVFSGLFVGGLPPELRA 164
G W S RI++Q + + ID + + + S D+ ++ GGLP
Sbjct: 2420 GKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLP----- 2474
Query: 165 AALKLTLASVRER---EPFKGWIRDVRVN 190
TL ++R + + G ++D+ ++
Sbjct: 2475 -----TLRNLRPEVNLKKYSGCLKDIEIS 2498
Score = 35.8 bits (81), Expect = 0.31
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 15/121 (12%)
Query: 81 LILTRGGRLQLSFSIFCAEPATLLADTPVN---DGAWHSVRIRRQFRNTTLFIDQVEAKW 137
+IL GRL++ S ++ N DG HSV + R T+ +D+ ++
Sbjct: 2583 VILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE-NRRY 2641
Query: 138 VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPV 197
++ + + + V LFVGG PPE + + L R PF+G I ++ +NS +P+
Sbjct: 2642 MQNLTVEQPIEV-KKLFVGGAPPEFQPSPL-------RNIPPFEGCIWNLVINS---VPM 2690
Query: 198 D 198
D
Sbjct: 2691 D 2691
Score = 35.0 bits (79), Expect = 0.54
Identities = 28/119 (23%), Positives = 47/119 (39%), Gaps = 12/119 (10%)
Query: 58 LKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSV 117
+KT A L+ Y F DFL + + R G++ + + D ++D W+ +
Sbjct: 2174 VKTAVADNLLFYLGSAKFIDFLAIEM-RKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRI 2232
Query: 118 RIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG-----------LFVGGLPPELRAA 165
R RN T+ + ++ + T G LFVGGL +L+ A
Sbjct: 2233 VASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKA 2291
Score = 32.3 bits (72), Expect = 3.5
Identities = 17/79 (21%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 1150 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIND 1209
+ + + T + +L + S+ + D+L + + +GK+ ++VG+ +E + I+D
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDD 2226
Query: 1210 GKYHVVRFTRSGGNATLQV 1228
++ + +R+G N T+ V
Sbjct: 2227 SYWYRIVASRTGRNGTISV 2245
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 104 bits (260), Expect = 6e-22
Identities = 169/780 (21%), Positives = 292/780 (37%), Gaps = 143/780 (18%)
Query: 538 VDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTP 597
+DF AIEM G + L D+GSG +++ ++D WY + R GR+GTISV L P
Sbjct: 2192 IDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2251
Query: 598 Y----------TAPGESEILDLDDE--LYLGGLPENKAGLVFPTEVWTALLNYGYVGCIR 645
T+P ILD+D L++GGL K V T + GC+
Sbjct: 2252 KASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT-GKLKKADAVRVIT------FTGCMG 2304
Query: 646 DLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGT 705
+ + D + + E + K C +P V D GT
Sbjct: 2305 ETYFDNKPIGLWNFREKEGDC-----------KGCTVSP-------------QVEDSEGT 2340
Query: 706 GYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSAD 765
+ +DG + + P+ + V +FR+ + +LM +RD D
Sbjct: 2341 -------------IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRD 2387
Query: 766 TLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 825
+ +EL G +K++ +L G ++ + N ND +W + + R K +++
Sbjct: 2388 FMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 826 DD-----QQAMTGQMAGDHTRLEF---HNIETGIITERRYLSSVP------SNFIGHLQS 871
D ++ + +G++ L+ I G + R LS + G L+
Sbjct: 2439 VDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKD 2498
Query: 872 LTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFF 931
+ + Y L DY + N+ V+F K +V L+ + +
Sbjct: 2499 IEISRTPYNIL---SSPDYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEINL 2552
Query: 932 QFKTTSLDGLILYNSG------------DGNDFIVVELVKGYLHYVFDLGNGANLIKGSS 979
F T + G+IL SG G + V+ L +G L L GA ++
Sbjct: 2553 SFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKIV 2610
Query: 980 NKP----LNDNQWHNVMISRDTSNLHTVKID-TKITTQITAGARNLDLKSDLYIGGVAKE 1034
+P +D + H+V + R T + TV++D + Q + +++K L++GG E
Sbjct: 2611 IRPEPNLFHDGREHSVHVER-TRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPE 2668
Query: 1035 TYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSN 1094
P + F+GC+ ++ +N D F N I R C ED +
Sbjct: 2669 FQ---PSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAAP 2724
Query: 1095 QGVCLQ----QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRAD 1150
+ +Q F + + I SK G +R
Sbjct: 2725 AEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFG------------LSRNS 2772
Query: 1151 RLAIGFSTVQKEAVL-----VRVDSSSGL---------GDYLELHIHQGKIGVKFNVGTD 1196
+AI F + + L VR ++ SGL D+ + + G +++G+
Sbjct: 2773 HIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSG 2832
Query: 1197 DIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGG 1256
D INDG++H ++ RS L VD R + ++ I + + +GG
Sbjct: 2833 DTHTMIPTK-INDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGG 2889
Score = 77.0 bits (188), Expect = 1e-13
Identities = 93/392 (23%), Positives = 163/392 (41%), Gaps = 49/392 (12%)
Query: 302 QSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVN 359
+ S + I ++ KT + L+ + G K D++ + ++ G VS + ++GSG VE +
Sbjct: 2164 KGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGV--GRVEYPD 2221
Query: 360 GKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDG----ILTTTGYTQED--YTMLGSDD- 412
+D+ W+ + +R +G + ++DG I+ +T ++ YT+L D
Sbjct: 2222 LTIDDSYWYRIVASR-----TGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDAN 2276
Query: 413 -FFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAF 471
+VGG + F GC+ E + N + L R K+GD K
Sbjct: 2277 AMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSPQVE 2335
Query: 472 KCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAK 531
E D + + +S P ++ F FRT + L+++ +
Sbjct: 2336 DSEGTIQFDGEGY----ALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLR----- 2386
Query: 532 HPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISV 591
DF ++E+ DGH+ + D+GSG + + + NDG+W R + IS+
Sbjct: 2387 -------DFMSVELTDGHIKVSYDLGSGMASVVS-NQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 592 NTLRT------PYTAPGESEILDL--DDELYLGGLPENKAGLVFPTEVWTALLNYGYVGC 643
+ T ++ G + LDL DD++Y GGLP + L L Y GC
Sbjct: 2439 VDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLR-NLSMKARPEVNLKKYS--GC 2495
Query: 644 IRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKE 675
++D+ I +I + GV CS E
Sbjct: 2496 LKDIEISRTPYNILSSPDY---VGVTKGCSLE 2524
Score = 69.3 bits (168), Expect = 3e-11
Identities = 161/816 (19%), Positives = 302/816 (37%), Gaps = 121/816 (14%)
Query: 294 YDLSQNPIQ--SSSDEITLSFKTLQRNGLMLH--TGKSADYVNLALKNGAVSLVINLGSG 349
Y L PI+ + + F+T + L+++ T D++++ L +G + + +LGSG
Sbjct: 2348 YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSG 2407
Query: 350 AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLG 409
+ N ND W ++R +++ + I + + + + T+ L
Sbjct: 2408 MASVVS---NQNHNDGKWKSFTLSR-IQKQANISIVDIDTNQEENIATSSSGNNFGLDLK 2463
Query: 410 SDDFFYVGGSPSTADLP--GSPVSN--NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKI 465
+DD Y GG P+ +L P N + GCLK++ E+SR
Sbjct: 2464 ADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDI---------EISRTPYNILSSPDY 2514
Query: 466 HGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKP 524
GV ENV T ++F P F+ L I+ F T +G+IL G
Sbjct: 2515 VGVTKGCSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGT 2570
Query: 525 RHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN---DGEWYHVDFQ 581
K Q + ++ I + G L + L G+ T++ + + N DG + V +
Sbjct: 2571 PAPPRRKRRQTGQA-YYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVE 2629
Query: 582 RDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYG-Y 640
R T+ V+ R + +++ +L++GG P P + L N +
Sbjct: 2630 RTRGIFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAP--------PEFQPSPLRNIPPF 2680
Query: 641 VGCIRDLFIDGQSKDIRQM-----AEVQSTAGVKPSCSKETAKPC--------------- 680
GCI +L I+ D + A++ A K ++ A P
Sbjct: 2681 EGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFP 2740
Query: 681 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 740
P +G C + G+ G S + D + ++ + + + TEAE
Sbjct: 2741 TPTPVLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAE 2798
Query: 741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 800
G+L + AD ++L G + +L G
Sbjct: 2799 S-----------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GSGDTHTMI 2838
Query: 801 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 860
+ND +WH ++++R + L VD T + + + Y+
Sbjct: 2839 PTKINDGQWHKIKIMRSKQEGILYVDGASNRT---------ISPKKADILDVVGMLYVGG 2889
Query: 861 VPSNFIGH-LQSLTFNGMAYIDLCKNG--------DIDYCELNARFGFRNIIADPVTFKT 911
+P N+ + +T++ ID C D++ + G A T+
Sbjct: 2890 LPINYTTRRIGPVTYS----IDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFD 2945
Query: 912 KSSYV-ALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGN 970
+ + A+ + + + F+F+TT+ G++L S D + +E++ L + D G
Sbjct: 2946 GTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGA 3005
Query: 971 GANLIKGSSNKP--LNDNQWHNVMISRDTSNLHTVKIDTKITTQI-TAGARNLDLKSDLY 1027
G + P L D QWH V ++ + ++ Q + + D ++
Sbjct: 3006 GRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVF 3065
Query: 1028 IGGVAKETYK-----SLPKLVHAKEGFQGCLASVDL 1058
+GG + + S+P F+GC+ S+ L
Sbjct: 3066 VGGFPDDLKQFGLTTSIP--------FRGCIRSLKL 3093
Score = 66.2 bits (160), Expect = 2e-10
Identities = 87/375 (23%), Positives = 147/375 (39%), Gaps = 54/375 (14%)
Query: 308 ITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 365
I L +T +GL+ + + AD+ + L+NG +LGSG ++ K ND
Sbjct: 2789 IELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPT---KINDG 2845
Query: 366 AWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADL 425
WH +K+ R+ ++ GI + VDG T + + +L YVGG P
Sbjct: 2846 QWHKIKIMRSKQE--GI------LYVDGASNRT-ISPKKADILDVVGMLYVGGLPINYTT 2896
Query: 426 PG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITF 484
PV+ + GC++ + LE P H F T F
Sbjct: 2897 RRIGPVTYSIDGCVRNLHMAEAPADLE--------QPTSSFHVGTCFANAQRGTY----F 2944
Query: 485 ETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIE 544
+ ++ + + F+FRTT G++L + K+D IE
Sbjct: 2945 DGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQ-------------KMDGMGIE 2991
Query: 545 MLDGHLYLLLDMGSG---TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAP 601
M+D L +D G+G + + + DG+W+ V + ++V+ + +P
Sbjct: 2992 MIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSP 3051
Query: 602 G-ESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDL-FIDGQSKDIR-Q 658
S D +D +++GG P++ T + + GCIR L G K +
Sbjct: 3052 NPASTSADTNDPVFVGGFPDDLKQFGLTTSI-------PFRGCIRSLKLTKGTGKPLEVN 3104
Query: 659 MAEVQSTAGVKP-SC 672
A+ GV+P SC
Sbjct: 3105 FAKALELRGVQPVSC 3119
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 3/106 (2%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+ +++T + GL+ Y DF + L R G S+ + + T++ T +NDG
Sbjct: 2789 IELEVRTEAESGLLFYMARINHADFATVQL-RNGLPYFSYDLGSGDTHTMIP-TKINDGQ 2846
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP 159
WH ++I R + L++D + + K K + V L+VGGLP
Sbjct: 2847 WHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVGMLYVGGLP 2891
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/303 (22%), Positives = 119/303 (39%), Gaps = 47/303 (15%)
Query: 934 KTTSLDGLILY-NSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVM 992
KT D L+ Y S DF+ +E+ KG + +++D+G+G ++ + ++D+ W+ ++
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 993 ISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGC 1052
SR N T R LD G A +P H+
Sbjct: 2234 ASRTGRN-------------GTISVRALD-------GPKA----SIVPSTHHSTSPPGYT 2269
Query: 1053 LASVDLN-----GRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSC 1107
+ VD N G L + A GC G E N+ + L +
Sbjct: 2270 ILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMG------ETYFDNKPIGLWNFREKEG 2323
Query: 1108 DCSMTSFSGPLCNDPGTTYIFSKGGGQIT--YKWPPNDRPSTRADRLAIGFSTVQKEAVL 1165
DC + S + + GT +G ++ +W PN + F T A+L
Sbjct: 2324 DCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPN------ISTVMFKFRTFSSSALL 2377
Query: 1166 VRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNAT 1225
+ + ++ L D++ + + G I V +++G+ +A SN NDGK+ +R A
Sbjct: 2378 MYL-ATRDLRDFMSVELTDGHIKVSYDLGS-GMASVVSNQNHNDGKWKSFTLSRIQKQAN 2435
Query: 1226 LQV 1228
+ +
Sbjct: 2436 ISI 2438
Score = 38.1 bits (87), Expect = 0.063
Identities = 34/146 (23%), Positives = 71/146 (48%), Gaps = 12/146 (8%)
Query: 52 SEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVND 111
S + F+ +T S+ L++Y DF+ + LT G +++S+ + A+++++ ND
Sbjct: 2362 STVMFKFRTFSSSALLMYLATRDLRDFMSVELT-DGHIKVSYDLGSGM-ASVVSNQNHND 2419
Query: 112 GAWHSV---RIRRQFRNTTLFIDQVEAKWVEVKSKRR----DMTVFSGLFVGGLPPELRA 164
G W S RI++Q + + ID + + + S D+ ++ GGL P LR
Sbjct: 2420 GKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGL-PTLRN 2478
Query: 165 AALKLTLASVREREPFKGWIRDVRVN 190
++K + + G ++D+ ++
Sbjct: 2479 LSMK--ARPEVNLKKYSGCLKDIEIS 2502
Score = 35.8 bits (81), Expect = 0.31
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 15/121 (12%)
Query: 81 LILTRGGRLQLSFSIFCAEPATLLADTPVN---DGAWHSVRIRRQFRNTTLFIDQVEAKW 137
+IL GRL++ S ++ N DG HSV + R T+ +D+ ++
Sbjct: 2587 VILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE-NRRY 2645
Query: 138 VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPV 197
++ + + + V LFVGG PPE + + L R PF+G I ++ +NS +P+
Sbjct: 2646 MQNLTVEQPIEV-KKLFVGGAPPEFQPSPL-------RNIPPFEGCIWNLVINS---VPM 2694
Query: 198 D 198
D
Sbjct: 2695 D 2695
Score = 35.0 bits (79), Expect = 0.54
Identities = 28/119 (23%), Positives = 47/119 (39%), Gaps = 12/119 (10%)
Query: 58 LKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSV 117
+KT A L+ Y F DFL + + R G++ + + D ++D W+ +
Sbjct: 2174 VKTAVADNLLFYLGSAKFIDFLAIEM-RKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRI 2232
Query: 118 RIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG-----------LFVGGLPPELRAA 165
R RN T+ + ++ + T G LFVGGL +L+ A
Sbjct: 2233 VASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKA 2291
Score = 32.3 bits (72), Expect = 3.5
Identities = 17/79 (21%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 1150 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIND 1209
+ + + T + +L + S+ + D+L + + +GK+ ++VG+ +E + I+D
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDD 2226
Query: 1210 GKYHVVRFTRSGGNATLQV 1228
++ + +R+G N T+ V
Sbjct: 2227 SYWYRIVASRTGRNGTISV 2245
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 102 bits (255), Expect = 2e-21
Identities = 108/402 (26%), Positives = 163/402 (40%), Gaps = 73/402 (18%)
Query: 54 MSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTPVN 110
M F++ R S G++LY D G DFL + L GG ++ F C L ++ P+
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDPLT 57
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRAAA 166
G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 58 LGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 117
Query: 167 LKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGG 226
LK PF G I+ + +N + VK D + G + A
Sbjct: 118 LK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCVRA 157
Query: 227 VCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATF 286
C +GG C + CDC GF G C + +E + I F
Sbjct: 158 PCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKA--IIEAIE----------------IPQF 198
Query: 287 KGSEYFCYDLSQNP-----IQSSSDEITLSFKTLQRNGLMLHTGKS-----ADYVNLALK 336
G Y YD NP + S + + FKT ++GL+L G S +D+++L L+
Sbjct: 199 IGRSYLTYD---NPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLR 255
Query: 337 NGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILT 396
+GA+ NLGSG + VNG FND WH VK R+ SG I+VD
Sbjct: 256 DGALVFSYNLGSGVASIM---VNGSFNDGRWHRVKAVRD--GQSG------KITVDDYGA 304
Query: 397 TTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
TG + L + YVGG A +GC+
Sbjct: 305 RTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCI 346
Score = 99.0 bits (245), Expect = 3e-20
Identities = 90/344 (26%), Positives = 152/344 (44%), Gaps = 26/344 (7%)
Query: 927 MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLND 985
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S PL
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
Query: 986 NQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLV 1043
WH + +SR N +++D + + G + +D++IGGV Y + K
Sbjct: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
Query: 1044 HAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWD 1103
+ F G + + LN R + D F +G E + C C++ G C + +
Sbjct: 116 GVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGSCRPRKE 170
Query: 1104 GFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLAIGFSTV 1159
G+ CDC + F G C I G +TY P R S + + F T
Sbjct: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
Query: 1160 QKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRF 1217
K+ +L+ R DS D++ L + G + +N+G+ +A N NDG++H V+
Sbjct: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGRWHRVKA 288
Query: 1218 TRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIIIGGKEQ 1259
R G + + VD + G RQL N + +GG ++
Sbjct: 289 VRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGGMKE 329
Score = 96.3 bits (238), Expect = 2e-19
Identities = 89/401 (22%), Positives = 173/401 (43%), Gaps = 68/401 (16%)
Query: 508 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 567
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 7 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 53
Query: 568 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 621
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 54 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 113
Query: 622 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 681
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 114 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 155
Query: 682 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 737
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 156 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 214
Query: 738 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 791
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 215 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 265
Query: 792 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 847
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 266 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 325
Query: 848 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 885
E + T R+Y+ + +G + T + +I L ++
Sbjct: 326 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 362
Score = 43.5 bits (101), Expect = 0.002
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 52 SEMSFQLKTRSARGLVLYFDDEGF---CDFLELILTRGGRLQLSFSIFCAEPATLLADTP 108
S + + KT + GL+L+ D DF+ L L R G L S+++ A+++ +
Sbjct: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSGV-ASIMVNGS 277
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGL 158
NDG WH V+ R ++ + +D A+ + R + + L+VGG+
Sbjct: 278 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 96.7 bits (239), Expect = 2e-19
Identities = 153/698 (21%), Positives = 266/698 (38%), Gaps = 139/698 (19%)
Query: 680 CLSNPCKNNGMC----RDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQL-PVV 734
C C NNG C +DG + + C C +GY G CE AT LS++G F+ ++ V
Sbjct: 445 CTHQQCLNNGTCIPHFQDGQHGFSCLCP-SGYTGSLCEI-ATTLSFEGDGFLWVKSGSVT 502
Query: 735 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 794
+++LRF++ + +L+ ++RD ++LEL +G + L++ ++ N SK
Sbjct: 503 TKGSVCNIALRFQTVQPMALLLFRSNRDVF--VKLELLSGYIHLSIQVN------NQSK- 553
Query: 795 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLE-------FHN- 846
LF +N +D EWH V V+ +++ LT+ D +A T LE F N
Sbjct: 554 -VLLFISHNTSDGEWHFVEVIF-AEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNS 611
Query: 847 ---------IETGIITERRYLSSVPSNFIGHLQSLT--FNGMAYIDLCKNGDI------- 888
G+ Y +F+G LQ + +N + ++ +
Sbjct: 612 FLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCV 671
Query: 889 --DYCE----------LNARFGF--------------RNIIADPVTFKTKSSYVALATLQ 922
D+CE +N + R +A + YV +
Sbjct: 672 RKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDE 731
Query: 923 AY-TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNK 981
+Y ++ L +T GL+L +I V L +G L + N L+
Sbjct: 732 SYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTP--NSPKLVV---KF 786
Query: 982 PLNDNQWHNVMISRDTSNLHTVKIDTKITTQ----ITAGARNLDLKSDLYIGGVAKETYK 1037
LND H + + + KI+ ++Q I+A ++ +YIGG+ +
Sbjct: 787 VLNDGNVHLISLK-----IKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQET 841
Query: 1038 SLPKLVHAKEGFQGCLASVDLNGR----LPDLISDALF--CNGQIERGCEGPSTTCQEDS 1091
L F+GC+ V LN + P+ ++A + +GC G ++ C+ +
Sbjct: 842 ELNGGF-----FKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNS-CKSNP 895
Query: 1092 CSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPG-----------------------TTYIF 1128
C N GVC +WD FSC C + SG C + +F
Sbjct: 896 CHNGGVCHSRWDDFSCSCPALT-SGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVF 954
Query: 1129 SKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIG 1188
+ GQI ++ N + + GF T +++ + ++L + I ++
Sbjct: 955 NGQSGQILFR--SNGNITRELTNITFGFRTRDANVIILHAEKEP---EFLNISIQDSRLF 1009
Query: 1189 VKFNVGTDDIAIE-ESNAIINDGKYHVVRFTRSGGNATLQVDSW--------PVIERYPA 1239
+ G + S +NDG +H V T S + Q W P + A
Sbjct: 1010 FQLQSGNSFYMLSLTSLQSVNDGTWHEV--TLSMTDPLSQTSRWQMEVDNETPFVTSTIA 1067
Query: 1240 GRQLTIFNSQATIIIGGK--EQGQPFQGQLSGLYYNGL 1275
L I +G + + + QG LS + G+
Sbjct: 1068 TGSLNFLKDNTDIYVGDRAIDNIKGLQGCLSTIEIGGI 1105
Score = 74.7 bits (182), Expect = 6e-13
Identities = 100/421 (23%), Positives = 177/421 (42%), Gaps = 62/421 (14%)
Query: 427 GSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFET 486
G S+ +GC + NN + + + G + G CE TL +FE
Sbjct: 435 GRDCSDILLGCTHQQCL-NNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTL---SFEG 490
Query: 487 PESFISLPKWNAKKTGS---ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAI 543
+ F+ + + GS I+ F+T +P L+LF R +D F +
Sbjct: 491 -DGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLF-----RSNRDV---------FVKL 535
Query: 544 EMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVD-FQRDGRSGTISVNTLRTPYTAPG 602
E+L G+++L + + + + + + +DGEW+ V+ + + T+ ++ + A
Sbjct: 536 ELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKA 595
Query: 603 ESEILDLDDEL------YLGGLPENKAGLVFPTEVWTALLNY-------GYVGCIRDLFI 649
+ L+ D + +LGGLP V T ALLN+ +VGC++D+ I
Sbjct: 596 PTP-LESDQSICAFQNSFLGGLP------VGMTSNGVALLNFYNMPSTPSFVGCLQDIKI 648
Query: 650 DGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLG 709
D + ++ S+ VK C ++ C S PC++ G C + W Y CDC Y G
Sbjct: 649 DWNHITLENISS-GSSLNVKAGCVRKDW--CESQPCQSRGRCINLWLSYQCDCH-RPYEG 704
Query: 710 RSCERE--ATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTL 767
+C RE A D S I + + +S+ R+ + G+L+A + +
Sbjct: 705 PNCLREYVAGRFGQDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLA-LENSTYQYI 763
Query: 768 RLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 827
R+ L+ GR+ + + NS K L + LND H + + + ++L
Sbjct: 764 RVWLERGRLAM--------LTPNSPK----LVVKFVLNDGNVHLISLKIKPYKIELYQSS 811
Query: 828 Q 828
Q
Sbjct: 812 Q 812
Score = 72.4 bits (176), Expect = 3e-12
Identities = 133/587 (22%), Positives = 211/587 (35%), Gaps = 141/587 (24%)
Query: 214 GSPCEAG-EEGEGGVCLNGGVCSVVDDQAVCDC-----SRTGFRGKDCS---------QE 258
G CE E C NGG C + C C SRT + G+DCS Q
Sbjct: 391 GIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQC 450
Query: 259 DNNVEGLAHLMMGDQGKS-------KGKEEYIAT---FKGSEYFCYDLSQNPIQSSSDEI 308
NN + H G G S G IAT F+G + + S I
Sbjct: 451 LNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTKGSVCNI 510
Query: 309 TLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWH 368
L F+T+Q L+L +V L L +G + L I + + + L ++ +D WH
Sbjct: 511 ALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQSKVLLF--ISHNTSDGEWH 568
Query: 369 DVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFF------YVGGSP-- 420
V+V I VT+++ + T L SD ++GG P
Sbjct: 569 FVEV---------IFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNSFLGGLPVG 619
Query: 421 ------STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCE 474
+ + P + +F+GCL+++ N + LE ++ +K V CE
Sbjct: 620 MTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLE--NISSGSSLNVKAGCVRKDWCE 677
Query: 475 NVATLD---------------PITFETP---ESFISLPKWNAKKTGSISFDF-------- 508
+ +E P +++ TG + F
Sbjct: 678 SQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDESYGDTI 737
Query: 509 ------RTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIK 562
RT +P+GL+L Q I+V L+ +L S +
Sbjct: 738 SLSMFVRTLQPSGLLLALENSTY--------QYIRV------WLERGRLAMLTPNSPKLV 783
Query: 563 IKALLKKVNDGEWYHVD----------FQRDGRSGTISVNTLRTPYTAPGESEILDLDDE 612
+K +L NDG + + +Q G IS +T + ++ D
Sbjct: 784 VKFVL---NDGNVHLISLKIKPYKIELYQSSQNLGFISASTWK-----------IEKGDV 829
Query: 613 LYLGGLPENKAGLVFPTEVWTALLNYGYV-GCIRDLFIDGQSKDIRQMAEVQSTAGVKPS 671
+Y+GGLP+ + TE LN G+ GCI+D+ ++ Q+ + + A + P
Sbjct: 830 IYIGGLPDKQ-----ETE-----LNGGFFKGCIQDVRLNNQNLEF--FPNPTNNASLNPV 877
Query: 672 CSKETA-----KPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 713
T C SNPC N G+C W+ + C C G++CE
Sbjct: 878 LVNVTQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCPAL-TSGKACE 923
Score = 69.7 bits (169), Expect = 2e-11
Identities = 125/631 (19%), Positives = 236/631 (37%), Gaps = 110/631 (17%)
Query: 675 ETAKP-CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPV 733
ET P C S PC NN C D + Y C C GY G CE + + + P
Sbjct: 299 ETLMPLCWSKPCHNNATCEDSVDNYTCHC-WPGYTGAQCEIDLNECNSN---------PC 348
Query: 734 VMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLD---CIRINCN 790
+ E ++S + R G+ + + +++ + + G + D C C
Sbjct: 349 QSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCI-CQPGFTGIHCEEDVNECSSNPCQ 407
Query: 791 SSKGPETLFAGYNLN---DNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI 847
+ E L Y + DN T R + L QQ + H + H
Sbjct: 408 NGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHG- 466
Query: 848 ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPV 907
+ PS + G L + L GD GF + + V
Sbjct: 467 ---------FSCLCPSGYTGSLCEIATT------LSFEGD----------GFLWVKSGSV 501
Query: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFD 967
T K +AL +F+T L+L+ S + + F+ +EL+ GY+H
Sbjct: 502 TTKGSVCNIAL-------------RFQTVQPMALLLFRS-NRDVFVKLELLSGYIHLSIQ 547
Query: 968 LGNGANLIKGSSNKPLNDNQWHNV-----------MISRDTSNLHTVKIDTKITTQITAG 1016
+ N + ++ S+ +D +WH V +I K T + + +
Sbjct: 548 VNNQSKVLLFISHNT-SDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSIC 606
Query: 1017 ARNLDLKSDLYIG----GVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFC 1072
A L +G GVA + ++P + F GCL + ++ L + +
Sbjct: 607 AFQNSFLGGLPVGMTSNGVALLNFYNMP----STPSFVGCLQDIKIDWNHITLENISSGS 662
Query: 1073 NGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGG 1132
+ ++ GC C+ C ++G C+ W + CDC + GP C Y+ + G
Sbjct: 663 SLNVKAGCVRKDW-CESQPCQSRGRCINLWLSYQCDCH-RPYEGPNCL---REYVAGRFG 717
Query: 1133 GQITYKWPPNDRPSTRADRLAIGF--STVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVK 1190
+ + + D +++ T+Q +L+ +++S+ Y+ + + +G++ +
Sbjct: 718 QDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENST--YQYIRVWLERGRLAM- 774
Query: 1191 FNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQA 1250
+ + ++ ++NDG H++ +L++ + IE Y + + L ++
Sbjct: 775 LTPNSPKLVVK---FVLNDGNVHLI---------SLKIKPYK-IELYQSSQNLGFISAST 821
Query: 1251 -------TIIIGGKEQGQPFQGQLSGLYYNG 1274
I IGG Q + +L+G ++ G
Sbjct: 822 WKIEKGDVIYIGGLPDKQ--ETELNGGFFKG 850
Score = 57.4 bits (137), Expect = 1e-07
Identities = 72/328 (21%), Positives = 130/328 (39%), Gaps = 34/328 (10%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+S ++T GL+L ++ + ++ + L RG L+ L+ +NDG
Sbjct: 739 LSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAMLT-----PNSPKLVVKFVLNDGN 792
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEV---KSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
H + ++ + L+ ++ K ++ D+ +++GGLP +
Sbjct: 793 VHLISLKIKPYKIELYQSSQNLGFISASTWKIEKGDV-----IYIGGLPDKQETEL---- 843
Query: 171 LASVREREPFKGWIRDVRVNSSQV--LPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVC 228
FKG I+DVR+N+ + P + L+ N G C + C
Sbjct: 844 -----NGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQG--CAGDNSCKSNPC 896
Query: 229 LNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKS--KGKEEYI-AT 285
NGGVC D C C GK C E+ G + G Q + +G E A
Sbjct: 897 HNGGVCHSRWDDFSCSCPALT-SGKAC--EEVQWCGFSPCPHGAQCQPVLQGFECIANAV 953
Query: 286 FKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVIN 345
F G S I IT F+T N ++LH K +++N+++++ + +
Sbjct: 954 FNGQSGQILFRSNGNITRELTNITFGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQ 1013
Query: 346 LGSGAFEALVEPVNGKFNDNAWHDVKVT 373
G+ + + + ND WH+V ++
Sbjct: 1014 SGNSFYMLSLTSLQ-SVNDGTWHEVTLS 1040
Score = 53.9 bits (128), Expect = 1e-06
Identities = 61/226 (26%), Positives = 93/226 (41%), Gaps = 40/226 (17%)
Query: 503 SISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIK 562
+I+F FRT + N +IL + +P +F I + D L+ L G+
Sbjct: 975 NITFGFRTRDANVIILHAEKEP--------------EFLNISIQDSRLFFQLQSGNSFYM 1020
Query: 563 IKAL-LKKVNDGEWYHVDFQR-DGRSGT----ISVNTLRTPYT----APGESEILDLDDE 612
+ L+ VNDG W+ V D S T + V+ TP+ A G L + +
Sbjct: 1021 LSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDN-ETPFVTSTIATGSLNFLKDNTD 1079
Query: 613 LYLGGLP-ENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQ----STAG 667
+Y+G +N GL L+ +G I + + I + E Q ST
Sbjct: 1080 IYVGDRAIDNIKGL-------QGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNS 1132
Query: 668 VKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 713
V C + C SNPC + G C D ++ Y C C G+ G+ CE
Sbjct: 1133 VVTGCLQLNV--CNSNPCLHGGNCEDIYSSYHCSCP-LGWSGKHCE 1175
Score = 52.0 bits (123), Expect = 4e-06
Identities = 46/213 (21%), Positives = 87/213 (40%), Gaps = 34/213 (15%)
Query: 928 HLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQ 987
++ F F+T + +IL+ + +F+ + + L + GN ++ +S + +ND
Sbjct: 975 NITFGFRTRDANVIILHAEKEP-EFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGT 1033
Query: 988 WHNVMISRDTSNLHT----VKIDTK---ITTQITAGARN-LDLKSDLYIGGVAKETYKSL 1039
WH V +S T +++D + +T+ I G+ N L +D+Y+G A + K
Sbjct: 1034 WHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDIYVGDRAIDNIK-- 1091
Query: 1040 PKLVHAKEGFQGCLASVDLNG-------------RLPDLISDALFCNGQIERGCEGPSTT 1086
G QGCL+++++ G P + GC
Sbjct: 1092 --------GLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCL-QLNV 1142
Query: 1087 CQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLC 1119
C + C + G C + + C C + +SG C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPL-GWSGKHC 1174
Score = 50.4 bits (119), Expect = 1e-05
Identities = 18/34 (52%), Positives = 24/34 (70%)
Query: 680 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 713
C S PC + G+C DG NRY C+C+G+G+ G CE
Sbjct: 266 CASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCE 299
Score = 45.1 bits (105), Expect = 5e-04
Identities = 91/444 (20%), Positives = 165/444 (37%), Gaps = 75/444 (16%)
Query: 22 GCWAELGSGLEFPGAEGQWTRF----PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCD 77
G E+ + L F G W + K + C ++ + +T L+L+ +
Sbjct: 477 GSLCEIATTLSFEGDGFLWVKSGSVTTKGSVC---NIALRFQTVQPMALLLFRSNRDVFV 533
Query: 78 FLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFID-----Q 132
LEL+ G + LS + L +DG WH V + T ID +
Sbjct: 534 KLELL---SGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEK 590
Query: 133 VEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALK-LTLASVREREPFKGWIRDVRVNS 191
AK + + F F+GGLP + + + L ++ F G ++D++++
Sbjct: 591 CIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDW 650
Query: 192 SQVLPVDSGEVKLDDEPPNSGGGSPCEAG----EEGEGGVCLNGGVCSVVDDQAVCDCSR 247
+ + E +SG +AG + E C + G C + CDC R
Sbjct: 651 NHITL----------ENISSGSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHR 700
Query: 248 TGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDE 307
+ G +C +E + G G+ I T +S D
Sbjct: 701 P-YEGPNCLRE---------YVAGRFGQDDSTGYVIFTLD--------------ESYGDT 736
Query: 308 ITLSF--KTLQRNGLMLHTGKSA-DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFND 364
I+LS +TLQ +GL+L S Y+ + L+ G +++ L + + +V+ V ND
Sbjct: 737 ISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAM---LTPNSPKLVVKFV---LND 790
Query: 365 NAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTAD 424
H ++ ++ + I + G+ + D Y+GG P +
Sbjct: 791 GNVH--LISLKIKPYK--------IELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQE 840
Query: 425 LPGSPVSNNFMGCLKEVVYKNNDV 448
+ F GC+++V N ++
Sbjct: 841 TELN--GGFFKGCIQDVRLNNQNL 862
Score = 41.6 bits (96), Expect = 0.006
Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 680 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYD 722
C S+PC+N +C+DG + Y C C GY GR C+ E + D
Sbjct: 152 CASSPCQNGAVCQDGIDGYSCFCV-PGYQGRHCDLEVDECASD 193
Score = 39.7 bits (91), Expect = 0.022
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 680 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 713
C S PC N C+D Y CDC+ G+LG CE
Sbjct: 228 CWSQPCLNGATCQDALGAYFCDCA-PGFLGDHCE 260
Score = 38.5 bits (88), Expect = 0.048
Identities = 21/79 (26%), Positives = 34/79 (43%), Gaps = 5/79 (6%)
Query: 1044 HAKEGFQGCLASVDLNGRLPDLISDALFCN---GQIERGCEGPSTTCQEDSCSNQGVCLQ 1100
H + C ++ ++G D ++ A C G CE CQ C+N C+
Sbjct: 1173 HCELNIDECFSNPCIHGNCSDRVA-AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCIS 1231
Query: 1101 QWDGFSCDCSMTSFSGPLC 1119
+G+SC C +F+G C
Sbjct: 1232 HTNGYSCLC-FGNFTGKFC 1249
Score = 37.4 bits (85), Expect = 0.11
Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 2/42 (4%)
Query: 672 CSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 713
C K+ + C S+PC N G+C+D N++ C C + G CE
Sbjct: 1294 CEKDIDE-CASDPCVNGGLCQDLLNKFQCLCD-VAFAGERCE 1333
Score = 37.0 bits (84), Expect = 0.14
Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 3/71 (4%)
Query: 1052 CLASVDLNGRLPDLISDALFCN---GQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCD 1108
C + LNG A FC+ G + CE + C C + G+C+ + +SC+
Sbjct: 228 CWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCN 287
Query: 1109 CSMTSFSGPLC 1119
C+ + F+G C
Sbjct: 288 CTGSGFTGTHC 298
Score = 35.4 bits (80), Expect = 0.41
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
Query: 672 CSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGT-GYLGRSCE 713
C+K + CLSN C+NN C+D C CS T L + C+
Sbjct: 27 CNKNNTR-CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCD 68
Score = 35.4 bits (80), Expect = 0.41
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 680 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCERE 715
C S+PCKN C + RY C C Y G +CE E
Sbjct: 190 CASDPCKNEATCLNEIGRYTCICP-HNYSGVNCELE 224
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 214 GSPCEAG-EEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
G CE +E CL+GG+C +++ C+C+ +GF G C
Sbjct: 256 GDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHC 298
Score = 33.1 bits (74), Expect = 2.0
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 679 PCLSNPCKNNGMC--RDGWNRYVCDCSGTGYLGRSCE 713
PC SNPC+ + C G ++C C GY G CE
Sbjct: 73 PCFSNPCQGSATCVNTPGERSFLCKCP-PGYSGTICE 108
Score = 32.3 bits (72), Expect = 3.5
Identities = 16/47 (34%), Positives = 20/47 (42%), Gaps = 1/47 (2%)
Query: 1074 GQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1120
G R CE C C N VC DG+SC C + + G C+
Sbjct: 139 GYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFC-VPGYQGRHCD 184
Score = 31.2 bits (69), Expect = 7.7
Identities = 14/40 (35%), Positives = 19/40 (47%), Gaps = 1/40 (2%)
Query: 1080 CEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLC 1119
CE C D C N G+C + F C C + +F+G C
Sbjct: 1294 CEKDIDECASDPCVNGGLCQDLLNKFQCLCDV-AFAGERC 1332
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 90.9 bits (224), Expect = 8e-18
Identities = 97/389 (24%), Positives = 154/389 (39%), Gaps = 93/389 (23%)
Query: 472 KCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAK 531
+CE A P P SF+ + ++S F T + +GL LF +G+ + K
Sbjct: 1512 RCEVAARSFP-----PSSFVMFRGLRQRFHLTLSLSFATVQQSGL-LFYNGR----LNEK 1561
Query: 532 HPQMIKVDFFAIEMLDGHLYLLLDMG-SGTIKIKALLKKVNDGEWYHVDFQRDGRSGTIS 590
H DF A+E++ G + L G S T+ + ++DG+W+ V + + T +
Sbjct: 1562 H------DFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDA 1615
Query: 591 VNTLRTPY---------------------------------TAPGESEILDLDDELYLGG 617
+ + P + LDL L LGG
Sbjct: 1616 LGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGG 1675
Query: 618 ---LPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSK 674
LPEN FP + ++GC+RDL IDG+ D MA + G C
Sbjct: 1676 VPNLPEN-----FPVS------HKDFIGCMRDLHIDGRRVD---MAAFVANNGTMAGCQA 1721
Query: 675 ETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE---------REATVLSYDGSM 725
+ C S PCKN+G C + W + CDC G+ G+ C+ R LS++
Sbjct: 1722 KLHF-CDSGPCKNSGFCSERWGSFSCDCP-VGFGGKDCQLTMAHPHHFRGNGTLSWNFGS 1779
Query: 726 FMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCI 785
M + +P + L FR++ G+LM + + TL +LD G + +TV
Sbjct: 1780 DMAVSVPWYL-------GLAFRTRATQGVLMQVQAGPHS-TLLCQLDRGLLSVTVTR--- 1828
Query: 786 RINCNSSKGPETLFAGYNLNDNEWHTVRV 814
S + L ++D WH +R+
Sbjct: 1829 ----GSGRASHLLLDQVTVSDGRWHDLRL 1853
Score = 89.0 bits (219), Expect = 3e-17
Identities = 81/341 (23%), Positives = 140/341 (41%), Gaps = 48/341 (14%)
Query: 913 SSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS--GDGNDFIVVELVKGYLHYVFDLGN 970
SS+V L+ + L F T GL+ YN + +DF+ +ELV G + + G
Sbjct: 1523 SSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 971 GANLIKGSSNKPLNDNQWHNVMI-----------------SRDTSNLHTVK-IDTKITTQ 1012
++ + L+D QWH V + S+D + +V D + Q
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
Query: 1013 I---------------TAGARNLDLKSDLYIGGVAKETYKSLPK-LVHAKEGFQGCLASV 1056
T+ ++LDL L +GGV +LP+ + + F GC+ +
Sbjct: 1643 FGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVP-----NLPENFPVSHKDFIGCMRDL 1697
Query: 1057 DLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSG 1116
++GR D+ A N GC+ C C N G C ++W FSCDC + F G
Sbjct: 1698 HIDGRRVDMA--AFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPV-GFGG 1754
Query: 1117 PLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGD 1176
C +G G +++ + +D + L + F T + VL++V +G
Sbjct: 1755 KDCQLTMAHPHHFRGNGTLSWNF-GSDMAVSVPWYLGLAFRTRATQGVLMQV--QAGPHS 1811
Query: 1177 YLELHIHQGKIGVKFNVGTDDIA-IEESNAIINDGKYHVVR 1216
L + +G + V G+ + + ++DG++H +R
Sbjct: 1812 TLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLR 1852
Score = 66.6 bits (161), Expect = 2e-10
Identities = 124/572 (21%), Positives = 202/572 (35%), Gaps = 130/572 (22%)
Query: 214 GSPCEAGEEGEG---GVCLNGGVCSVVDDQAV-CDCSRTG-FRGKDCSQEDNNVEGLAHL 268
G CE E GVC NGG C+ + C C G F G C + + +
Sbjct: 1467 GEDCELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFV 1526
Query: 269 MMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-- 326
M F+G Q ++LSF T+Q++GL+ + G+
Sbjct: 1527 M----------------FRGLR-----------QRFHLTLSLSFATVQQSGLLFYNGRLN 1559
Query: 327 -SADYVNLALKNGAVSLVINLGSGAFEALVEP-VNGKFNDNAWHDVKVTR-NLRQHSGIG 383
D++ L L G V L + G +V P V G +D WH V + N + +G
Sbjct: 1560 EKHDFLALELVAGQVRLTYSTGES--NTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALG 1617
Query: 384 HA-------MVTISVDGI----------------LTTTGYTQEDYTMLGSDDFFYVGGSP 420
A + +SVD G L +GG P
Sbjct: 1618 GAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVP 1677
Query: 421 STADLPGSPVSN-NFMGCLKEVVYKNN--DVRLELSRLAKQGDPKMKIHGVVAFKCENVA 477
+ + PVS+ +F+GC++++ D+ ++ + K+H + C+N
Sbjct: 1678 NLPE--NFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSG 1735
Query: 478 TLD----------PITFETPESFISLP-----------KWNAKKTGSISFD------FRT 510
P+ F + +++ WN ++S FRT
Sbjct: 1736 FCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRT 1795
Query: 511 TEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLK-K 569
G+++ P H ++ ++ G L + + GSG L +
Sbjct: 1796 RATQGVLMQVQAGP-------HSTLL------CQLDRGLLSVTVTRGSGRASHLLLDQVT 1842
Query: 570 VNDGEWY--HVDFQRD--GRSG----TISVNTLRTPYTAPGESEILDLD-DELYLGGLPE 620
V+DG W+ ++ Q + GR G +S++ T SE+ L +L++GGLP
Sbjct: 1843 VSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPP 1902
Query: 621 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 680
A G VGCI+ +++ + +P C A C
Sbjct: 1903 GSAEEA----------PQGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCVVTNA--C 1950
Query: 681 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 712
S PC + CRD W + C C GY G C
Sbjct: 1951 ASGPCPPHADCRDLWQTFSCTCQ-PGYYGPGC 1981
Score = 62.0 bits (149), Expect = 4e-09
Identities = 121/538 (22%), Positives = 202/538 (37%), Gaps = 112/538 (20%)
Query: 672 CSKET-AKPCLSNPCKNNGMCRDGWN-RYVCDC-SGTGYLGRSCEREATVLSYDGSMFMK 728
C +T A C+ C+N G C D N + C C +G + G CE A S+ S F+
Sbjct: 1470 CELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAAR--SFPPSSFVM 1527
Query: 729 IQ-LPVVMHTEAEDVSLRFRSQRAYGILMAT-TSRDSADTLRLELDAGRVKLTVNLDCIR 786
+ L H +SL F + + G+L + D L LEL AG+V+LT +
Sbjct: 1528 FRGLRQRFHL---TLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTG--- 1581
Query: 787 INCNSSKGPETLFAGYNLNDNEWHTVRV----------------VRRGKSLKLTVDDQQ- 829
N+ P T+ G L+D +WHTV + + K L+VDD
Sbjct: 1582 -ESNTVVSP-TVPGG--LSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDV 1637
Query: 830 -------AMTGQMAGDHTRLEFHNIETGIITERRYLSSVPS----------NFIGHLQSL 872
A G + ++ + ++ +T L VP+ +FIG ++ L
Sbjct: 1638 AVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKDFIGCMRDL 1697
Query: 873 TFNGMAYIDL----CKNGDIDYCELNARF---------GF-----RNIIAD-PVTFKTKS 913
+G +D+ NG + C+ F GF + D PV F K
Sbjct: 1698 HIDGRR-VDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKD 1756
Query: 914 SYVALA-----------------TLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVE 956
+ +A + +L F+T + G+++ + ++ +
Sbjct: 1757 CQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQ 1816
Query: 957 LVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMI-------SRDTSNLHTVKIDTKI 1009
L +G L G+G ++D +WH++ + R ++ V +D +
Sbjct: 1817 LDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSL 1876
Query: 1010 ---TTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGR---LP 1063
T + + + L +K L++GG+ + + P +G GC+ V L P
Sbjct: 1877 FQDTMAVGSELQGLKVK-QLHVGGLPPGSAEEAP------QGLVGCIQGVWLGSTPSGSP 1929
Query: 1064 DLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCND 1121
L+ + N E GC + C C C W FSC C + GP C D
Sbjct: 1930 ALLPPSHRVNA--EPGCV-VTNACASGPCPPHADCRDLWQTFSCTC-QPGYYGPGCVD 1983
Score = 55.5 bits (132), Expect = 4e-07
Identities = 98/414 (23%), Positives = 159/414 (38%), Gaps = 106/414 (25%)
Query: 77 DFLELILTRGGRLQLSFSIFCAEPATLLADTP---VNDGAWHSVRIRRQFRNTT------ 127
DFL L L G+++L++S E T+++ T ++DG WH+V +R + T
Sbjct: 1563 DFLALELV-AGQVRLTYST--GESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGA 1619
Query: 128 ----------LFIDQVE-----------------AKWVEVKSKRRDMTVFSGLFVGGLP- 159
L +D + A V+ SK+ + + L +GG+P
Sbjct: 1620 QGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKK-SLDLTGPLLLGGVPN 1678
Query: 160 -PELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCE 218
PE + K F G +RD L +D V + N+G + C+
Sbjct: 1679 LPENFPVSHK----------DFIGCMRD--------LHIDGRRVDMAAFVANNGTMAGCQ 1720
Query: 219 AGEEG-EGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSK 277
A + G C N G CS CDC GF GKDC +AH
Sbjct: 1721 AKLHFCDSGPCKNSGFCSERWGSFSCDCP-VGFGGKDCQLT------MAH---------- 1763
Query: 278 GKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLA-LK 336
F+G+ ++ + S + L+F+T G+++ L L
Sbjct: 1764 -----PHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLD 1818
Query: 337 NGAVSLVINLGSG-AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGIL 395
G +S+ + GSG A L++ V +D WHD+++ GH ++ +S+D L
Sbjct: 1819 RGLLSVTVTRGSGRASHLLLDQVT--VSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSL 1876
Query: 396 TTTGYTQEDYTMLGSD------DFFYVGGSPSTADLPGS--PVSNNFMGCLKEV 441
+D +GS+ +VGG P PGS +GC++ V
Sbjct: 1877 F------QDTMAVGSELQGLKVKQLHVGGLP-----PGSAEEAPQGLVGCIQGV 1919
Score = 41.2 bits (95), Expect = 0.007
Identities = 36/172 (20%), Positives = 69/172 (40%), Gaps = 36/172 (20%)
Query: 1080 CEGPSTTCQEDSCSNQGVCLQQWDGFSC---------DCSMTSFSG----PLCNDPGTTY 1126
CE C + C N G C ++ G++C DC + + +G +C + GT
Sbjct: 1432 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCT 1491
Query: 1127 IFSKGGGQ----------------ITYKWPPNDRPSTRADR------LAIGFSTVQKEAV 1164
GG + +PP+ R R L++ F+TVQ+ +
Sbjct: 1492 DAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGL 1551
Query: 1165 LVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES-NAIINDGKYHVV 1215
L + D+L L + G++ + ++ G + + + ++DG++H V
Sbjct: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTV 1603
>gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 87.4 bits (215), Expect = 9e-17
Identities = 162/843 (19%), Positives = 311/843 (36%), Gaps = 131/843 (15%)
Query: 286 FKGSEYFCY-DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVI 344
F GS Y D+++ + +T NGL+L + + L ++NG + +
Sbjct: 1045 FDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFY 1104
Query: 345 NLGSGAFEALVEPV--NGKFNDNAWHDVKVT-RNLRQHSGIGHAMVTISVDGILTTTGYT 401
+ G +E + ND +H++ + N ++ + S+D +T
Sbjct: 1105 DFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFT 1164
Query: 402 QEDYTMLGSDDFFYVGGSP-----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLA 456
Y+GG+P S A P+ NF GC+K ++ D L L +
Sbjct: 1165 D-----------IYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNL-LEQTE 1212
Query: 457 KQGDPKMKIHGVVAFKCENVATLDPITFETPESFI-SLPKWNAKKTGSISFDFRTTEPNG 515
G V + C + + + +SFI S+ K + F+FRT +PNG
Sbjct: 1213 TLG---------VGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNG 1263
Query: 516 LILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEW 575
L+ + D F+I + +G + ++D+ IK++++ K+ NDG
Sbjct: 1264 LLFYYASGS--------------DVFSISLDNGTV--IMDVKG--IKVQSVDKQYNDGLS 1305
Query: 576 YHVDFQRDGRSGTISVNTLRTPYTAPGESEILDL---DDELYLGGLPENKAGLVFPTEVW 632
+ V + V+ R P + +I + + Y GG P
Sbjct: 1306 HFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSP------------- 1352
Query: 633 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSC----------------SKET 676
+ + GCI + + +D+ + T V S K
Sbjct: 1353 ISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNL 1412
Query: 677 AKPCLSNPCKNNGMCRDG--WNRYVCDCSGTG-------YLGRSCEREATVLSYDGSMFM 727
+KP S K G +D W+ +L S Y G+
Sbjct: 1413 SKPKASQN-KKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANS 1471
Query: 728 KIQLPVVMHTEAE-----DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNL 782
+ + H + + S+R R++ ++G++ + ++ D + L L GR+ N+
Sbjct: 1472 RQEFE---HLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNV 1528
Query: 783 DCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRL 842
++ S + ND WH V +R S +L +D + + +
Sbjct: 1529 GHKKLKIRSQE---------KYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATW 1579
Query: 843 EFHN-IETGIITERRYLSSVPSN----FIGHLQSLTFNGMAYIDLCKNGDIDYCELNARF 897
+ I G + + + +V N F G L +L NG + + + C
Sbjct: 1580 KIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPC------ 1633
Query: 898 GFRNIIADPVTFKTKSSYVAL-ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVE 956
F + F T+ YV L + + F+ + S G +++ +++ V
Sbjct: 1634 -FEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVH 1692
Query: 957 LVKGYLHYVFDLGNGANLIKGS--SNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQI- 1013
+ G + + + NG S + L D +WH + + RD SN+ + +D+++ +
Sbjct: 1693 MKNGQV--IVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRD-SNVVQLDVDSEVNHVVG 1749
Query: 1014 TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCN 1073
+ +D + +++GGV + P+L +K F GC+ ++G P S A +
Sbjct: 1750 PLNPKPIDHREPVFVGGVPESLL--TPRLAPSKP-FTGCIRHFVIDGH-PVSFSKAALVS 1805
Query: 1074 GQI 1076
G +
Sbjct: 1806 GAV 1808
Score = 58.2 bits (139), Expect = 6e-08
Identities = 87/370 (23%), Positives = 142/370 (38%), Gaps = 53/370 (14%)
Query: 329 DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG-HAMV 387
+Y+ LA+KN + V NLG+ E ++ + VK+ R +G H V
Sbjct: 886 EYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIER-------VGKHGKV 938
Query: 388 TISVDGILTTT-------GYTQEDYTMLG---SDDFFYVGGSPSTADLPGSPVSNNFMGC 437
++V + +T G D ++L D FYVGG PS LP S F+GC
Sbjct: 939 FLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGC 998
Query: 438 LKEVVYKNNDVRLELSRLAKQGDPKMKI---HGVVAFKCENVAT--LDPITFETPESFIS 492
L+ N+ + L + DP + +AF A+ D +
Sbjct: 999 LELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITR 1058
Query: 493 LPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL 552
K+ + + RT NGLIL FF +EM +G+L++
Sbjct: 1059 RGKFG--QVTRFDIEVRTPADNGLILLMVNGSM--------------FFRLEMRNGYLHV 1102
Query: 553 LLDMG--SGTIKIKALLKK--VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 608
D G G + ++ LKK +ND +++ + I V R + E +
Sbjct: 1103 FYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIP 1162
Query: 609 LDDELYLGGLPENKAGLVFPTEVWTA--LLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTA 666
D +Y+GG P + + A L+ + GC++ Q KD + E T
Sbjct: 1163 FTD-IYIGGAPPE----ILQSRALRAHLPLDINFRGCMKG--FQFQKKDF-NLLEQTETL 1214
Query: 667 GVKPSCSKET 676
GV C +++
Sbjct: 1215 GVGYGCPEDS 1224
Score = 53.1 bits (126), Expect = 2e-06
Identities = 157/817 (19%), Positives = 293/817 (35%), Gaps = 155/817 (18%)
Query: 537 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYH--VDFQRDGRSGTISVNTL 594
K ++ + + + +L + ++G+ ++I K V+ Y V +R G+ G + +
Sbjct: 884 KKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVP 943
Query: 595 RTPYTAP----------GESEILDLDDE---LYLGGLPENKAGLVFPTEVWTALLNYGYV 641
TA G+ +LDLD E Y+GG+P N ++ T+L G+V
Sbjct: 944 SLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSN-------FKLPTSLNLPGFV 996
Query: 642 GCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCD 701
GC+ + + D+ + + + PS S A+ L+ + Y D
Sbjct: 997 GCLE---LATLNNDVISLYNFKHIYNMDPSTSVPCARDKLA-------FTQSRAASYFFD 1046
Query: 702 CSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSR 761
G+GY + R+ T G + D+ +R + +LM S
Sbjct: 1047 --GSGY---AVVRDITRRGKFGQV------------TRFDIEVRTPADNGLILLMVNGSM 1089
Query: 762 DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP---ETLFAGYNLNDNEWHTVRVV-RR 817
RLE+ G + + + S GP E +ND ++H + ++
Sbjct: 1090 ----FFRLEMRNGYLHVFYDF-------GFSGGPVHLEDTLKKAQINDAKYHEISIIYHN 1138
Query: 818 GKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETG-----IITERRYLSSVPS--NFIGHLQ 870
K + L VD + + M + ++ F +I G I+ R + +P NF G ++
Sbjct: 1139 DKKMILVVDRRHVKS--MDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1196
Query: 871 SLTFNGMAYIDLCKNGDIDYCELNARFGFR------NIIADPVTFKTKSSYVALATLQAY 924
F + D + E G ++I+ F +S ++ + +
Sbjct: 1197 GFQF---------QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFF 1247
Query: 925 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 984
F F+T +GL+ Y + G+D + L G + + D+ + S +K N
Sbjct: 1248 DGFEGGFNFRTLQPNGLLFYYAS-GSDVFSISLDNGTV--IMDV---KGIKVQSVDKQYN 1301
Query: 985 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1044
D H V+ S + + +++ G++N K+ Y +
Sbjct: 1302 DGLSHFVISSVSPTRYELIVDKSRV------GSKNPTKGKIEQTQASEKKFYFGGSPISA 1355
Query: 1045 AKEGFQGCLAS-----VDLNGRLPD----------------LISDALFCNGQIERGCEGP 1083
F GC+++ VD + + D + S LF + + P
Sbjct: 1356 QYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKP 1415
Query: 1084 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI---TYKWP 1140
+ + ++ WD + P N P ++ + Y++
Sbjct: 1416 KASQNKKGGKSKDA--PSWDPVALKL-------PERNTPRNSHCHLSNSPRAIEHAYQYG 1466
Query: 1141 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGL---------GDYLELHIHQGKIGVKF 1191
+ L F + ++ +R SS G+ D++ L + G++ F
Sbjct: 1467 GTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMF 1526
Query: 1192 NVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQAT 1251
NVG + I S NDG +H V F R + L +D V+E + T + +
Sbjct: 1527 NVGHKKLKIR-SQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEAT-WKIKGP 1584
Query: 1252 IIIGGKEQGQ-----------PFQGQLSGLYYNGLKV 1277
I +GG G+ F G LS L NG +
Sbjct: 1585 IYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASI 1621
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
+S+ S +L+TRS+ G++ Y D+ DF+ L L GRL F++ + + + N
Sbjct: 1485 KSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAH-GRLVYMFNV-GHKKLKIRSQEKYN 1542
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
DG WH V R+ + L ID + + + +++GG+ P A +
Sbjct: 1543 DGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP--GKAVKNVQ 1600
Query: 171 LASVREREPFKGWIRDVRVNSSQV 194
+ S+ F G + ++++N + +
Sbjct: 1601 INSIYS---FSGCLSNLQLNGASI 1621
Score = 49.7 bits (117), Expect = 2e-05
Identities = 72/383 (18%), Positives = 142/383 (37%), Gaps = 67/383 (17%)
Query: 304 SSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 361
+ + ++ +T +G++ + + D++ L L +G + + N+G + + K
Sbjct: 1484 AKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQE---K 1540
Query: 362 FNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILT---TTGYTQEDYTMLGSDDFFYVGG 418
+ND WHDV R + SG + +DG+ + T+ + + G Y+GG
Sbjct: 1541 YNDGLWHDVIFIRE--RSSG------RLVIDGLRVLEESLPPTEATWKIKGP---IYLGG 1589
Query: 419 SPSTADLPGSPVSN-------NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAF 471
PG V N +F GCL + + +
Sbjct: 1590 VA-----PGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFS-------------VT 1631
Query: 472 KCENVATLDPITFETPESFISLPK-WNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDA 530
C F T ++ L + +N I+F+ R +G ++ H
Sbjct: 1632 PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHS-------- 1683
Query: 531 KHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTI 589
+ ++ + M +G + + ++ G K+ + DG W+ + RD +
Sbjct: 1684 -----VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQL 1738
Query: 590 SVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFI 649
V++ P + +D + +++GG+PE+ L+ P + + GCIR I
Sbjct: 1739 DVDSEVNHVVGPLNPKPIDHREPVFVGGVPES---LLTP----RLAPSKPFTGCIRHFVI 1791
Query: 650 DGQSKDIRQMAEVQSTAGVKPSC 672
DG + A V + SC
Sbjct: 1792 DGHPVSFSKAALVSGAVSIN-SC 1813
Score = 35.8 bits (81), Expect = 0.31
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 35 GAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFS 94
G GQ TRF +++T + GL+L + LE+ R G L + +
Sbjct: 1060 GKFGQVTRF-----------DIEVRTPADNGLILLMVNGSMFFRLEM---RNGYLHVFYD 1105
Query: 95 I-FCAEPATL---LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF 150
F P L L +ND +H + I + N I V+ + V+ + F
Sbjct: 1106 FGFSGGPVHLEDTLKKAQINDAKYHEISII--YHNDKKMILVVDRRHVKSMDNEKMKIPF 1163
Query: 151 SGLFVGGLPPE-LRAAALKLTL 171
+ +++GG PPE L++ AL+ L
Sbjct: 1164 TDIYIGGAPPEILQSRALRAHL 1185
>gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]
Length = 1823
Score = 87.4 bits (215), Expect = 9e-17
Identities = 162/843 (19%), Positives = 311/843 (36%), Gaps = 131/843 (15%)
Query: 286 FKGSEYFCY-DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVI 344
F GS Y D+++ + +T NGL+L + + L ++NG + +
Sbjct: 1052 FDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFY 1111
Query: 345 NLGSGAFEALVEPV--NGKFNDNAWHDVKVT-RNLRQHSGIGHAMVTISVDGILTTTGYT 401
+ G +E + ND +H++ + N ++ + S+D +T
Sbjct: 1112 DFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFT 1171
Query: 402 QEDYTMLGSDDFFYVGGSP-----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLA 456
Y+GG+P S A P+ NF GC+K ++ D L L +
Sbjct: 1172 D-----------IYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNL-LEQTE 1219
Query: 457 KQGDPKMKIHGVVAFKCENVATLDPITFETPESFI-SLPKWNAKKTGSISFDFRTTEPNG 515
G V + C + + + +SFI S+ K + F+FRT +PNG
Sbjct: 1220 TLG---------VGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNG 1270
Query: 516 LILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEW 575
L+ + D F+I + +G + ++D+ IK++++ K+ NDG
Sbjct: 1271 LLFYYASGS--------------DVFSISLDNGTV--IMDVKG--IKVQSVDKQYNDGLS 1312
Query: 576 YHVDFQRDGRSGTISVNTLRTPYTAPGESEILDL---DDELYLGGLPENKAGLVFPTEVW 632
+ V + V+ R P + +I + + Y GG P
Sbjct: 1313 HFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSP------------- 1359
Query: 633 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSC----------------SKET 676
+ + GCI + + +D+ + T V S K
Sbjct: 1360 ISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNL 1419
Query: 677 AKPCLSNPCKNNGMCRDG--WNRYVCDCSGTG-------YLGRSCEREATVLSYDGSMFM 727
+KP S K G +D W+ +L S Y G+
Sbjct: 1420 SKPKASQN-KKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANS 1478
Query: 728 KIQLPVVMHTEAE-----DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNL 782
+ + H + + S+R R++ ++G++ + ++ D + L L GR+ N+
Sbjct: 1479 RQEFE---HLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNV 1535
Query: 783 DCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRL 842
++ S + ND WH V +R S +L +D + + +
Sbjct: 1536 GHKKLKIRSQE---------KYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATW 1586
Query: 843 EFHN-IETGIITERRYLSSVPSN----FIGHLQSLTFNGMAYIDLCKNGDIDYCELNARF 897
+ I G + + + +V N F G L +L NG + + + C
Sbjct: 1587 KIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPC------ 1640
Query: 898 GFRNIIADPVTFKTKSSYVAL-ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVE 956
F + F T+ YV L + + F+ + S G +++ +++ V
Sbjct: 1641 -FEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVH 1699
Query: 957 LVKGYLHYVFDLGNGANLIKGS--SNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQI- 1013
+ G + + + NG S + L D +WH + + RD SN+ + +D+++ +
Sbjct: 1700 MKNGQV--IVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRD-SNVVQLDVDSEVNHVVG 1756
Query: 1014 TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCN 1073
+ +D + +++GGV + P+L +K F GC+ ++G P S A +
Sbjct: 1757 PLNPKPIDHREPVFVGGVPESLL--TPRLAPSKP-FTGCIRHFVIDGH-PVSFSKAALVS 1812
Query: 1074 GQI 1076
G +
Sbjct: 1813 GAV 1815
Score = 58.2 bits (139), Expect = 6e-08
Identities = 87/370 (23%), Positives = 142/370 (38%), Gaps = 53/370 (14%)
Query: 329 DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG-HAMV 387
+Y+ LA+KN + V NLG+ E ++ + VK+ R +G H V
Sbjct: 893 EYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIER-------VGKHGKV 945
Query: 388 TISVDGILTTT-------GYTQEDYTMLG---SDDFFYVGGSPSTADLPGSPVSNNFMGC 437
++V + +T G D ++L D FYVGG PS LP S F+GC
Sbjct: 946 FLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGC 1005
Query: 438 LKEVVYKNNDVRLELSRLAKQGDPKMKI---HGVVAFKCENVAT--LDPITFETPESFIS 492
L+ N+ + L + DP + +AF A+ D +
Sbjct: 1006 LELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITR 1065
Query: 493 LPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL 552
K+ + + RT NGLIL FF +EM +G+L++
Sbjct: 1066 RGKFG--QVTRFDIEVRTPADNGLILLMVNGSM--------------FFRLEMRNGYLHV 1109
Query: 553 LLDMG--SGTIKIKALLKK--VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 608
D G G + ++ LKK +ND +++ + I V R + E +
Sbjct: 1110 FYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIP 1169
Query: 609 LDDELYLGGLPENKAGLVFPTEVWTA--LLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTA 666
D +Y+GG P + + A L+ + GC++ Q KD + E T
Sbjct: 1170 FTD-IYIGGAPPE----ILQSRALRAHLPLDINFRGCMKG--FQFQKKDF-NLLEQTETL 1221
Query: 667 GVKPSCSKET 676
GV C +++
Sbjct: 1222 GVGYGCPEDS 1231
Score = 53.1 bits (126), Expect = 2e-06
Identities = 157/817 (19%), Positives = 293/817 (35%), Gaps = 155/817 (18%)
Query: 537 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYH--VDFQRDGRSGTISVNTL 594
K ++ + + + +L + ++G+ ++I K V+ Y V +R G+ G + +
Sbjct: 891 KKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVP 950
Query: 595 RTPYTAP----------GESEILDLDDE---LYLGGLPENKAGLVFPTEVWTALLNYGYV 641
TA G+ +LDLD E Y+GG+P N ++ T+L G+V
Sbjct: 951 SLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSN-------FKLPTSLNLPGFV 1003
Query: 642 GCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCD 701
GC+ + + D+ + + + PS S A+ L+ + Y D
Sbjct: 1004 GCLE---LATLNNDVISLYNFKHIYNMDPSTSVPCARDKLA-------FTQSRAASYFFD 1053
Query: 702 CSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSR 761
G+GY + R+ T G + D+ +R + +LM S
Sbjct: 1054 --GSGY---AVVRDITRRGKFGQV------------TRFDIEVRTPADNGLILLMVNGSM 1096
Query: 762 DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP---ETLFAGYNLNDNEWHTVRVV-RR 817
RLE+ G + + + S GP E +ND ++H + ++
Sbjct: 1097 ----FFRLEMRNGYLHVFYDF-------GFSGGPVHLEDTLKKAQINDAKYHEISIIYHN 1145
Query: 818 GKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETG-----IITERRYLSSVPS--NFIGHLQ 870
K + L VD + + M + ++ F +I G I+ R + +P NF G ++
Sbjct: 1146 DKKMILVVDRRHVKS--MDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1203
Query: 871 SLTFNGMAYIDLCKNGDIDYCELNARFGFR------NIIADPVTFKTKSSYVALATLQAY 924
F + D + E G ++I+ F +S ++ + +
Sbjct: 1204 GFQF---------QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFF 1254
Query: 925 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 984
F F+T +GL+ Y + G+D + L G + + D+ + S +K N
Sbjct: 1255 DGFEGGFNFRTLQPNGLLFYYAS-GSDVFSISLDNGTV--IMDV---KGIKVQSVDKQYN 1308
Query: 985 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1044
D H V+ S + + +++ G++N K+ Y +
Sbjct: 1309 DGLSHFVISSVSPTRYELIVDKSRV------GSKNPTKGKIEQTQASEKKFYFGGSPISA 1362
Query: 1045 AKEGFQGCLAS-----VDLNGRLPD----------------LISDALFCNGQIERGCEGP 1083
F GC+++ VD + + D + S LF + + P
Sbjct: 1363 QYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKP 1422
Query: 1084 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI---TYKWP 1140
+ + ++ WD + P N P ++ + Y++
Sbjct: 1423 KASQNKKGGKSKDA--PSWDPVALKL-------PERNTPRNSHCHLSNSPRAIEHAYQYG 1473
Query: 1141 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGL---------GDYLELHIHQGKIGVKF 1191
+ L F + ++ +R SS G+ D++ L + G++ F
Sbjct: 1474 GTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMF 1533
Query: 1192 NVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQAT 1251
NVG + I S NDG +H V F R + L +D V+E + T + +
Sbjct: 1534 NVGHKKLKIR-SQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEAT-WKIKGP 1591
Query: 1252 IIIGGKEQGQ-----------PFQGQLSGLYYNGLKV 1277
I +GG G+ F G LS L NG +
Sbjct: 1592 IYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASI 1628
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
+S+ S +L+TRS+ G++ Y D+ DF+ L L GRL F++ + + + N
Sbjct: 1492 KSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAH-GRLVYMFNV-GHKKLKIRSQEKYN 1549
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
DG WH V R+ + L ID + + + +++GG+ P A +
Sbjct: 1550 DGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP--GKAVKNVQ 1607
Query: 171 LASVREREPFKGWIRDVRVNSSQV 194
+ S+ F G + ++++N + +
Sbjct: 1608 INSIYS---FSGCLSNLQLNGASI 1628
Score = 49.7 bits (117), Expect = 2e-05
Identities = 72/383 (18%), Positives = 142/383 (37%), Gaps = 67/383 (17%)
Query: 304 SSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 361
+ + ++ +T +G++ + + D++ L L +G + + N+G + + K
Sbjct: 1491 AKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQE---K 1547
Query: 362 FNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILT---TTGYTQEDYTMLGSDDFFYVGG 418
+ND WHDV R + SG + +DG+ + T+ + + G Y+GG
Sbjct: 1548 YNDGLWHDVIFIRE--RSSG------RLVIDGLRVLEESLPPTEATWKIKGP---IYLGG 1596
Query: 419 SPSTADLPGSPVSN-------NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAF 471
PG V N +F GCL + + +
Sbjct: 1597 VA-----PGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFS-------------VT 1638
Query: 472 KCENVATLDPITFETPESFISLPK-WNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDA 530
C F T ++ L + +N I+F+ R +G ++ H
Sbjct: 1639 PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHS-------- 1690
Query: 531 KHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTI 589
+ ++ + M +G + + ++ G K+ + DG W+ + RD +
Sbjct: 1691 -----VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQL 1745
Query: 590 SVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFI 649
V++ P + +D + +++GG+PE+ L+ P + + GCIR I
Sbjct: 1746 DVDSEVNHVVGPLNPKPIDHREPVFVGGVPES---LLTP----RLAPSKPFTGCIRHFVI 1798
Query: 650 DGQSKDIRQMAEVQSTAGVKPSC 672
DG + A V + SC
Sbjct: 1799 DGHPVSFSKAALVSGAVSIN-SC 1820
Score = 35.8 bits (81), Expect = 0.31
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 35 GAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFS 94
G GQ TRF +++T + GL+L + LE+ R G L + +
Sbjct: 1067 GKFGQVTRF-----------DIEVRTPADNGLILLMVNGSMFFRLEM---RNGYLHVFYD 1112
Query: 95 I-FCAEPATL---LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF 150
F P L L +ND +H + I + N I V+ + V+ + F
Sbjct: 1113 FGFSGGPVHLEDTLKKAQINDAKYHEISII--YHNDKKMILVVDRRHVKSMDNEKMKIPF 1170
Query: 151 SGLFVGGLPPE-LRAAALKLTL 171
+ +++GG PPE L++ AL+ L
Sbjct: 1171 TDIYIGGAPPEILQSRALRAHL 1192
>gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 87.4 bits (215), Expect = 9e-17
Identities = 162/843 (19%), Positives = 311/843 (36%), Gaps = 131/843 (15%)
Query: 286 FKGSEYFCY-DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVI 344
F GS Y D+++ + +T NGL+L + + L ++NG + +
Sbjct: 1045 FDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFY 1104
Query: 345 NLGSGAFEALVEPV--NGKFNDNAWHDVKVT-RNLRQHSGIGHAMVTISVDGILTTTGYT 401
+ G +E + ND +H++ + N ++ + S+D +T
Sbjct: 1105 DFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIPFT 1164
Query: 402 QEDYTMLGSDDFFYVGGSP-----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLA 456
Y+GG+P S A P+ NF GC+K ++ D L L +
Sbjct: 1165 D-----------IYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNL-LEQTE 1212
Query: 457 KQGDPKMKIHGVVAFKCENVATLDPITFETPESFI-SLPKWNAKKTGSISFDFRTTEPNG 515
G V + C + + + +SFI S+ K + F+FRT +PNG
Sbjct: 1213 TLG---------VGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFRTLQPNG 1263
Query: 516 LILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEW 575
L+ + D F+I + +G + ++D+ IK++++ K+ NDG
Sbjct: 1264 LLFYYASGS--------------DVFSISLDNGTV--IMDVKG--IKVQSVDKQYNDGLS 1305
Query: 576 YHVDFQRDGRSGTISVNTLRTPYTAPGESEILDL---DDELYLGGLPENKAGLVFPTEVW 632
+ V + V+ R P + +I + + Y GG P
Sbjct: 1306 HFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSP------------- 1352
Query: 633 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSC----------------SKET 676
+ + GCI + + +D+ + T V S K
Sbjct: 1353 ISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNL 1412
Query: 677 AKPCLSNPCKNNGMCRDG--WNRYVCDCSGTG-------YLGRSCEREATVLSYDGSMFM 727
+KP S K G +D W+ +L S Y G+
Sbjct: 1413 SKPKASQN-KKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANS 1471
Query: 728 KIQLPVVMHTEAE-----DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNL 782
+ + H + + S+R R++ ++G++ + ++ D + L L GR+ N+
Sbjct: 1472 RQEFE---HLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNV 1528
Query: 783 DCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRL 842
++ S + ND WH V +R S +L +D + + +
Sbjct: 1529 GHKKLKIRSQE---------KYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATW 1579
Query: 843 EFHN-IETGIITERRYLSSVPSN----FIGHLQSLTFNGMAYIDLCKNGDIDYCELNARF 897
+ I G + + + +V N F G L +L NG + + + C
Sbjct: 1580 KIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPC------ 1633
Query: 898 GFRNIIADPVTFKTKSSYVAL-ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVE 956
F + F T+ YV L + + F+ + S G +++ +++ V
Sbjct: 1634 -FEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNGEYLNVH 1692
Query: 957 LVKGYLHYVFDLGNGANLIKGS--SNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQI- 1013
+ G + + + NG S + L D +WH + + RD SN+ + +D+++ +
Sbjct: 1693 MKNGQV--IVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRD-SNVVQLDVDSEVNHVVG 1749
Query: 1014 TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCN 1073
+ +D + +++GGV + P+L +K F GC+ ++G P S A +
Sbjct: 1750 PLNPKPIDHREPVFVGGVPESLL--TPRLAPSKP-FTGCIRHFVIDGH-PVSFSKAALVS 1805
Query: 1074 GQI 1076
G +
Sbjct: 1806 GAV 1808
Score = 58.2 bits (139), Expect = 6e-08
Identities = 87/370 (23%), Positives = 142/370 (38%), Gaps = 53/370 (14%)
Query: 329 DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG-HAMV 387
+Y+ LA+KN + V NLG+ E ++ + VK+ R +G H V
Sbjct: 886 EYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIER-------VGKHGKV 938
Query: 388 TISVDGILTTT-------GYTQEDYTMLG---SDDFFYVGGSPSTADLPGSPVSNNFMGC 437
++V + +T G D ++L D FYVGG PS LP S F+GC
Sbjct: 939 FLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGC 998
Query: 438 LKEVVYKNNDVRLELSRLAKQGDPKMKI---HGVVAFKCENVAT--LDPITFETPESFIS 492
L+ N+ + L + DP + +AF A+ D +
Sbjct: 999 LELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITR 1058
Query: 493 LPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL 552
K+ + + RT NGLIL FF +EM +G+L++
Sbjct: 1059 RGKFG--QVTRFDIEVRTPADNGLILLMVNGSM--------------FFRLEMRNGYLHV 1102
Query: 553 LLDMG--SGTIKIKALLKK--VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 608
D G G + ++ LKK +ND +++ + I V R + E +
Sbjct: 1103 FYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIP 1162
Query: 609 LDDELYLGGLPENKAGLVFPTEVWTA--LLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTA 666
D +Y+GG P + + A L+ + GC++ Q KD + E T
Sbjct: 1163 FTD-IYIGGAPPE----ILQSRALRAHLPLDINFRGCMKG--FQFQKKDF-NLLEQTETL 1214
Query: 667 GVKPSCSKET 676
GV C +++
Sbjct: 1215 GVGYGCPEDS 1224
Score = 53.1 bits (126), Expect = 2e-06
Identities = 157/817 (19%), Positives = 293/817 (35%), Gaps = 155/817 (18%)
Query: 537 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYH--VDFQRDGRSGTISVNTL 594
K ++ + + + +L + ++G+ ++I K V+ Y V +R G+ G + +
Sbjct: 884 KKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVP 943
Query: 595 RTPYTAP----------GESEILDLDDE---LYLGGLPENKAGLVFPTEVWTALLNYGYV 641
TA G+ +LDLD E Y+GG+P N ++ T+L G+V
Sbjct: 944 SLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSN-------FKLPTSLNLPGFV 996
Query: 642 GCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCD 701
GC+ + + D+ + + + PS S A+ L+ + Y D
Sbjct: 997 GCLE---LATLNNDVISLYNFKHIYNMDPSTSVPCARDKLA-------FTQSRAASYFFD 1046
Query: 702 CSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSR 761
G+GY + R+ T G + D+ +R + +LM S
Sbjct: 1047 --GSGY---AVVRDITRRGKFGQV------------TRFDIEVRTPADNGLILLMVNGSM 1089
Query: 762 DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP---ETLFAGYNLNDNEWHTVRVV-RR 817
RLE+ G + + + S GP E +ND ++H + ++
Sbjct: 1090 ----FFRLEMRNGYLHVFYDF-------GFSGGPVHLEDTLKKAQINDAKYHEISIIYHN 1138
Query: 818 GKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETG-----IITERRYLSSVPS--NFIGHLQ 870
K + L VD + + M + ++ F +I G I+ R + +P NF G ++
Sbjct: 1139 DKKMILVVDRRHVKS--MDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1196
Query: 871 SLTFNGMAYIDLCKNGDIDYCELNARFGFR------NIIADPVTFKTKSSYVALATLQAY 924
F + D + E G ++I+ F +S ++ + +
Sbjct: 1197 GFQF---------QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFF 1247
Query: 925 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 984
F F+T +GL+ Y + G+D + L G + + D+ + S +K N
Sbjct: 1248 DGFEGGFNFRTLQPNGLLFYYAS-GSDVFSISLDNGTV--IMDV---KGIKVQSVDKQYN 1301
Query: 985 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1044
D H V+ S + + +++ G++N K+ Y +
Sbjct: 1302 DGLSHFVISSVSPTRYELIVDKSRV------GSKNPTKGKIEQTQASEKKFYFGGSPISA 1355
Query: 1045 AKEGFQGCLAS-----VDLNGRLPD----------------LISDALFCNGQIERGCEGP 1083
F GC+++ VD + + D + S LF + + P
Sbjct: 1356 QYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKP 1415
Query: 1084 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI---TYKWP 1140
+ + ++ WD + P N P ++ + Y++
Sbjct: 1416 KASQNKKGGKSKDA--PSWDPVALKL-------PERNTPRNSHCHLSNSPRAIEHAYQYG 1466
Query: 1141 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGL---------GDYLELHIHQGKIGVKF 1191
+ L F + ++ +R SS G+ D++ L + G++ F
Sbjct: 1467 GTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMF 1526
Query: 1192 NVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQAT 1251
NVG + I S NDG +H V F R + L +D V+E + T + +
Sbjct: 1527 NVGHKKLKIR-SQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEAT-WKIKGP 1584
Query: 1252 IIIGGKEQGQ-----------PFQGQLSGLYYNGLKV 1277
I +GG G+ F G LS L NG +
Sbjct: 1585 IYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASI 1621
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
+S+ S +L+TRS+ G++ Y D+ DF+ L L GRL F++ + + + N
Sbjct: 1485 KSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAH-GRLVYMFNV-GHKKLKIRSQEKYN 1542
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
DG WH V R+ + L ID + + + +++GG+ P A +
Sbjct: 1543 DGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP--GKAVKNVQ 1600
Query: 171 LASVREREPFKGWIRDVRVNSSQV 194
+ S+ F G + ++++N + +
Sbjct: 1601 INSIYS---FSGCLSNLQLNGASI 1621
Score = 49.7 bits (117), Expect = 2e-05
Identities = 72/383 (18%), Positives = 142/383 (37%), Gaps = 67/383 (17%)
Query: 304 SSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 361
+ + ++ +T +G++ + + D++ L L +G + + N+G + + K
Sbjct: 1484 AKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQE---K 1540
Query: 362 FNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILT---TTGYTQEDYTMLGSDDFFYVGG 418
+ND WHDV R + SG + +DG+ + T+ + + G Y+GG
Sbjct: 1541 YNDGLWHDVIFIRE--RSSG------RLVIDGLRVLEESLPPTEATWKIKGP---IYLGG 1589
Query: 419 SPSTADLPGSPVSN-------NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAF 471
PG V N +F GCL + + +
Sbjct: 1590 VA-----PGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFS-------------VT 1631
Query: 472 KCENVATLDPITFETPESFISLPK-WNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDA 530
C F T ++ L + +N I+F+ R +G ++ H
Sbjct: 1632 PCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHS-------- 1683
Query: 531 KHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTI 589
+ ++ + M +G + + ++ G K+ + DG W+ + RD +
Sbjct: 1684 -----VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQL 1738
Query: 590 SVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFI 649
V++ P + +D + +++GG+PE+ L+ P + + GCIR I
Sbjct: 1739 DVDSEVNHVVGPLNPKPIDHREPVFVGGVPES---LLTP----RLAPSKPFTGCIRHFVI 1791
Query: 650 DGQSKDIRQMAEVQSTAGVKPSC 672
DG + A V + SC
Sbjct: 1792 DGHPVSFSKAALVSGAVSIN-SC 1813
Score = 35.8 bits (81), Expect = 0.31
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 35 GAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFS 94
G GQ TRF +++T + GL+L + LE+ R G L + +
Sbjct: 1060 GKFGQVTRF-----------DIEVRTPADNGLILLMVNGSMFFRLEM---RNGYLHVFYD 1105
Query: 95 I-FCAEPATL---LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF 150
F P L L +ND +H + I + N I V+ + V+ + F
Sbjct: 1106 FGFSGGPVHLEDTLKKAQINDAKYHEISII--YHNDKKMILVVDRRHVKSMDNEKMKIPF 1163
Query: 151 SGLFVGGLPPE-LRAAALKLTL 171
+ +++GG PPE L++ AL+ L
Sbjct: 1164 TDIYIGGAPPEILQSRALRAHL 1185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,753,348
Number of Sequences: 37866
Number of extensions: 2671483
Number of successful extensions: 10329
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 7592
Number of HSP's gapped (non-prelim): 1971
length of query: 1477
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1362
effective length of database: 13,892,928
effective search space: 18922167936
effective search space used: 18922167936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.