Guide to the Human Genome
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Search of human proteins with 14149607

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14149607 chloride channel 7 isoform a [Homo sapiens]
         (805 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14149607 chloride channel 7 isoform a [Homo sapiens]              1597   0.0  
gi|167466160 chloride channel 7 isoform b [Homo sapiens]             1536   0.0  
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]           528   e-150
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]          288   1e-77
gi|189217923 chloride channel 5 isoform a [Homo sapiens]              261   2e-69
gi|189217921 chloride channel 5 isoform a [Homo sapiens]              261   2e-69
gi|4557473 chloride channel 5 isoform b [Homo sapiens]                261   2e-69
gi|153252026 chloride channel 4 [Homo sapiens]                        253   4e-67
gi|55770838 chloride channel 3 isoform b [Homo sapiens]               253   6e-67
gi|55770840 chloride channel 3 isoform e [Homo sapiens]               248   1e-65
gi|156104869 chloride channel 2 [Homo sapiens]                        191   2e-48
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]       183   6e-46
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]          179   1e-44
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]          179   1e-44
gi|155969705 chloride channel Kb [Homo sapiens]                       167   5e-41
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]             147   4e-35
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]             146   7e-35
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora...    32   2.3  
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora...    32   2.3  
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora...    32   2.3  
gi|18702331 OTU domain containing 7A [Homo sapiens]                    32   2.3  
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]                    32   2.3  
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  
gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]        31   4.0  

>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
          Length = 805

 Score = 1597 bits (4134), Expect = 0.0
 Identities = 805/805 (100%), Positives = 805/805 (100%)

Query: 1   MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 60
           MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
Sbjct: 1   MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 60

Query: 61  SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 120
           SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
Sbjct: 61  SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 120

Query: 121 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 180
           TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
Sbjct: 121 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 180

Query: 181 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 240
           TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
Sbjct: 181 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 240

Query: 241 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 300
           GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
Sbjct: 241 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 300

Query: 301 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 360
           FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
Sbjct: 301 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 360

Query: 361 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 420
           GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
Sbjct: 361 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 420

Query: 421 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 480
           AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
Sbjct: 421 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 480

Query: 481 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 540
           PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
Sbjct: 481 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 540

Query: 541 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 600
           WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
Sbjct: 541 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 600

Query: 601 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 660
           LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
Sbjct: 601 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 660

Query: 661 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 720
           FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
Sbjct: 661 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 720

Query: 721 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 780
           IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
Sbjct: 721 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 780

Query: 781 LVTRKDLARYRLGKRGLEELSLAQT 805
           LVTRKDLARYRLGKRGLEELSLAQT
Sbjct: 781 LVTRKDLARYRLGKRGLEELSLAQT 805


>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
          Length = 781

 Score = 1536 bits (3978), Expect = 0.0
 Identities = 781/805 (97%), Positives = 781/805 (97%), Gaps = 24/805 (2%)

Query: 1   MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS 60
           MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQ             
Sbjct: 1   MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQ------------- 47

Query: 61  SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 120
                      DMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
Sbjct: 48  -----------DMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR 96

Query: 121 TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 180
           TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
Sbjct: 97  TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA 156

Query: 181 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 240
           TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
Sbjct: 157 TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG 216

Query: 241 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 300
           GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
Sbjct: 217 GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA 276

Query: 301 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 360
           FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
Sbjct: 277 FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF 336

Query: 361 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 420
           GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
Sbjct: 337 GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV 396

Query: 421 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 480
           AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
Sbjct: 397 AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD 456

Query: 481 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 540
           PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
Sbjct: 457 PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI 516

Query: 541 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 600
           WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
Sbjct: 517 WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG 576

Query: 601 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 660
           LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
Sbjct: 577 LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG 636

Query: 661 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 720
           FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
Sbjct: 637 FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP 696

Query: 721 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 780
           IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
Sbjct: 697 IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG 756

Query: 781 LVTRKDLARYRLGKRGLEELSLAQT 805
           LVTRKDLARYRLGKRGLEELSLAQT
Sbjct: 757 LVTRKDLARYRLGKRGLEELSLAQT 781


>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
          Length = 869

 Score =  528 bits (1360), Expect = e-150
 Identities = 313/724 (43%), Positives = 446/724 (61%), Gaps = 48/724 (6%)

Query: 94  YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
           YESLDYD   N  +LE    +++   R  E  +W++   IG+ TGLV  F+D  V     
Sbjct: 48  YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107

Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
           LK+ V++ ++++ ++KG L+ SLL     N  FV + S++V  IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166

Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
           NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++  
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226

Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
             F YFR D +KRDFVSAGAAAGV+AAFGAP+GG LFSLEEG+SFWNQ LTW++ F SM 
Sbjct: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286

Query: 334 STFTLNFVLS-IYHGNMWDLSSPGLINFGRF---DSEKMA--YTIHEIPVFIAMGVVGGV 387
           +TFTLNF  S I  G+      PGL+NFG F   DS+K    +T  ++  F+ MGV+GG+
Sbjct: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGL 346

Query: 388 LGAVFNALNYWLTMFRIRYIH-RPCL-QVIEAVLVAAVTATVAFVLIYSSRDCQPL---- 441
           LGA FN LN  L  +R+R +H +P L +V+E++LV+ VT  V FV      +C+ +    
Sbjct: 347 LGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSS 406

Query: 442 QGGSMSYPLQL-----------FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTL 490
           Q G+ S+ LQ+           FC +  YN MA  FFN  E +++ LFH   G+++P+TL
Sbjct: 407 QIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATLFFNPQESAILQLFHQ-DGTFSPVTL 465

Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLF-GISLSYLTGAAIWADPGKYAL 549
            LF ++YF LACWTYG++V +G+F+PSLL GAA+GRL   +  SY+    I++  G +AL
Sbjct: 466 ALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHIYS--GTFAL 523

Query: 550 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQ 609
           +GAAA LGG+VRMT+SLTVI++E+T+ +TYG PIM+ LM AK  GD F +G+YD+H+ L+
Sbjct: 524 IGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLR 583

Query: 610 SVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADD 669
            VP L WE  V    L A ++M   +T +    ++  +V +L  T   H+ FPVV     
Sbjct: 584 GVPLLEWETEVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTV--HHAFPVVTENRG 641

Query: 670 TQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYP--RFPPIQSIHVS 727
            +   ++G  L S  I   K  +          ++R R +  + +YP      +   H++
Sbjct: 642 NEKEFMKGNQLISNNIKFKKSSILTRAG-----EQRKRSQSMK-SYPSSELRNMCDEHIA 695

Query: 728 QDERECTMDLSEFM-----NPSPYTVPQEASLP--RVFKLFRALGLRHLVVVDNRNQVVG 780
            +E     DL + M      P P   P ++      + + FR L    L++   R+Q+V 
Sbjct: 696 SEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLIL---RSQLVT 752

Query: 781 LVTR 784
           L+ R
Sbjct: 753 LLVR 756



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 46/117 (39%), Positives = 68/117 (58%)

Query: 671 QPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDE 730
           +P    GLILRSQL+ LL   V    S     Q RL   +  + YPR+P I  + ++   
Sbjct: 737 RPLTFHGLILRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLN 796

Query: 731 RECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
               +D++ +MNPSP+TV     + +VF LFR +GLRHL VV+   ++VG++TR +L
Sbjct: 797 PRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNL 853


>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
          Length = 353

 Score =  288 bits (737), Expect = 1e-77
 Identities = 149/273 (54%), Positives = 193/273 (70%), Gaps = 2/273 (0%)

Query: 94  YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
           YESLDYD   N  +LE    +++   R  E  +W++   IG+ TGLV  F+D  V     
Sbjct: 48  YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107

Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
           LK+ V++ ++++ ++KG L+ SLL     N  FV + S++V  IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166

Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
           NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++  
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226

Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
             F YFR D +KRDFVSAGAAAGV+AAFGAP+GG LFSLEEG+SFWNQ LTW++ F SM 
Sbjct: 227 FNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMS 286

Query: 334 STFTLNFVLS-IYHGNMWDLSSPGLINFGRFDS 365
           +TFTLNF  S I  G+      PGL+NFG F S
Sbjct: 287 ATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKS 319


>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score =  261 bits (667), Expect = 2e-69
 Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
           W++  LIG+L+G +A  IDI    +  LK  +  G                     DK  
Sbjct: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187

Query: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
                      T++G  +     F  +LWA L   F  +   +V    P A GSGIP+IK
Sbjct: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244

Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
             L+G  I   +   TLVIK   ++L+V  GL++GKEGP++H     G+++    +    
Sbjct: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300

Query: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
                     +Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++     WR
Sbjct: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350

Query: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
            FFA++++ FTL  +    +  +       ++ +  F +    + + E+  FI +G+ GG
Sbjct: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400

Query: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
           + GA+F   N  W    +   + +    VIE ++V A+TA +AF   Y+      L    
Sbjct: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456

Query: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
                +LF   G  +S         FNT +   +       G Y+ +  L L  ++   +
Sbjct: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511

Query: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
             +T+G+ + +G+FIPS+ +GA  GRL G+ +              S+ +  A    PG 
Sbjct: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571

Query: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
           YA++GAAA LGG+ RMT+SL VIM E T  + Y  P+M   MT+K V D    EG+YD H
Sbjct: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631

Query: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
           I+L   PFL  +    +H   A +VM    + P+  +  ++ + V  +  ++S+T   ++
Sbjct: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688

Query: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
           GFPVV      +  RL G +LR  LI+ +++     +   G+V   +    F +  P  P
Sbjct: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740

Query: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
           P             T+ L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++
Sbjct: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790

Query: 780 GLVTRKDLARY 790
           G++T+KD+ ++
Sbjct: 791 GIITKKDVLKH 801


>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score =  261 bits (667), Expect = 2e-69
 Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
           W++  LIG+L+G +A  IDI    +  LK  +  G                     DK  
Sbjct: 128 WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 187

Query: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
                      T++G  +     F  +LWA L   F  +   +V    P A GSGIP+IK
Sbjct: 188 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 244

Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
             L+G  I   +   TLVIK   ++L+V  GL++GKEGP++H     G+++    +    
Sbjct: 245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 300

Query: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
                     +Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++     WR
Sbjct: 301 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 350

Query: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
            FFA++++ FTL  +    +  +       ++ +  F +    + + E+  FI +G+ GG
Sbjct: 351 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 400

Query: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
           + GA+F   N  W    +   + +    VIE ++V A+TA +AF   Y+      L    
Sbjct: 401 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 456

Query: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
                +LF   G  +S         FNT +   +       G Y+ +  L L  ++   +
Sbjct: 457 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 511

Query: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
             +T+G+ + +G+FIPS+ +GA  GRL G+ +              S+ +  A    PG 
Sbjct: 512 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 571

Query: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
           YA++GAAA LGG+ RMT+SL VIM E T  + Y  P+M   MT+K V D    EG+YD H
Sbjct: 572 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 631

Query: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
           I+L   PFL  +    +H   A +VM    + P+  +  ++ + V  +  ++S+T   ++
Sbjct: 632 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 688

Query: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
           GFPVV      +  RL G +LR  LI+ +++     +   G+V   +    F +  P  P
Sbjct: 689 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 740

Query: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
           P             T+ L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++
Sbjct: 741 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 790

Query: 780 GLVTRKDLARY 790
           G++T+KD+ ++
Sbjct: 791 GIITKKDVLKH 801


>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
          Length = 746

 Score =  261 bits (667), Expect = 2e-69
 Identities = 217/731 (29%), Positives = 352/731 (48%), Gaps = 124/731 (16%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI-------------------DK-- 165
           W++  LIG+L+G +A  IDI    +  LK  +  G                     DK  
Sbjct: 58  WLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCP 117

Query: 166 ----------FTEKGGLS-----FSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
                      T++G  +     F  +LWA L   F  +   +V    P A GSGIP+IK
Sbjct: 118 EWNSWSQLIISTDEGAFAYIVNYFMYVLWALL---FAFLAVSLVKVFAPYACGSGIPEIK 174

Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIH----SGSVIAAGISQGRS 266
             L+G  I   +   TLVIK   ++L+V  GL++GKEGP++H     G+++    +    
Sbjct: 175 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFN---- 230

Query: 267 TSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWR 326
                     +Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++     WR
Sbjct: 231 ----------KYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWR 280

Query: 327 IFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGG 386
            FFA++++ FTL  +    +  +       ++ +  F +    + + E+  FI +G+ GG
Sbjct: 281 SFFAALVAAFTLRSINPFGNSRL-------VLFYVEFHT---PWHLFELVPFILLGIFGG 330

Query: 387 VLGAVFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGS 445
           + GA+F   N  W    +   + +    VIE ++V A+TA +AF   Y+      L    
Sbjct: 331 LWGALFIRTNIAWCRKRKTTQLGK--YPVIEVLVVTAITAILAFPNEYTRMSTSELIS-- 386

Query: 446 MSYPLQLFCADGEYNSMAAA----FFNTPEKSVVSLFHDPPGSYNPL-TLGLFTLVYFFL 500
                +LF   G  +S         FNT +   +       G Y+ +  L L  ++   +
Sbjct: 387 -----ELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVI 441

Query: 501 ACWTYGLTVSAGVFIPSLLIGAAWGRLFGISL--------------SYLTGAAIWADPGK 546
             +T+G+ + +G+FIPS+ +GA  GRL G+ +              S+ +  A    PG 
Sbjct: 442 TIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGL 501

Query: 547 YALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMH 605
           YA++GAAA LGG+ RMT+SL VIM E T  + Y  P+M   MT+K V D    EG+YD H
Sbjct: 502 YAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAH 561

Query: 606 IQLQSVPFLHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHN 659
           I+L   PFL  +    +H   A +VM    + P+  +  ++ + V  +  ++S+T   ++
Sbjct: 562 IRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISET--TYS 618

Query: 660 GFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFP 719
           GFPVV      +  RL G +LR  LI+ +++     +   G+V   +    F +  P  P
Sbjct: 619 GFPVVV---SRESQRLVGFVLRRDLIISIEN---ARKKQDGVVSTSIIY--FTEHSPPLP 670

Query: 720 PIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVV 779
           P             T+ L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++
Sbjct: 671 PY---------TPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHN-GRLL 720

Query: 780 GLVTRKDLARY 790
           G++T+KD+ ++
Sbjct: 721 GIITKKDVLKH 731


>gi|153252026 chloride channel 4 [Homo sapiens]
          Length = 760

 Score =  253 bits (647), Expect = 4e-67
 Identities = 220/727 (30%), Positives = 338/727 (46%), Gaps = 115/727 (15%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNI----------------------- 163
           WV+  LIG+L G +A  ID+ V+ +  LK  V                            
Sbjct: 71  WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130

Query: 164 --DKFTE------KGGLSFSL-----LLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK 210
              K++E      +G  ++ L     +LWA L   F  +   +V    P A GSGIP+IK
Sbjct: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALL---FAFLAVSLVRVFAPYACGSGIPEIK 187

Query: 211 CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLK 270
             L+G  I   +   TL+IK   ++L V  GL++GKEGP++H         S   S    
Sbjct: 188 TILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFS---- 243

Query: 271 RDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFA 330
                 +Y + + ++R+ +SA AAAGVS AFGAP+GGVLFSLEE + ++     WR FFA
Sbjct: 244 ------KYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFA 297

Query: 331 SMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGA 390
           ++++ FTL         ++    +  L+ F  +      + + E+  FI +GV GG+ G 
Sbjct: 298 ALVAAFTLR--------SINPFGNSRLVLF--YVEYHTPWYMAELFPFILLGVFGGLWGT 347

Query: 391 VFNALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYP 449
           +F   N  W    +   + +    V+E ++V A+TA +A+   Y+ +    L        
Sbjct: 348 LFIRCNIAWCRRRKTTRLGK--YPVLEVIVVTAITAIIAYPNPYTRQSTSELIS------ 399

Query: 450 LQLFCADGEY-NSMAAAFFNTPEKS-VVSLFHDPPGSYNPLT----LGLFTLVYFFLACW 503
            +LF   G   +S    + N P  +  V    D P      T    L L  +    +  +
Sbjct: 400 -ELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIF 458

Query: 504 TYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLT--------------GAAIWADPGKYAL 549
           T+G+ + +G+FIPS+ +GA  GR+ GI +  L                 A    PG YA+
Sbjct: 459 TFGMKIPSGLFIPSMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAM 518

Query: 550 MGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQL 608
           +GAAA LGG+ RMT+SL VIM E T  + Y  P+M   +T+K V D F  EG+Y+ HI L
Sbjct: 519 VGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHL 578

Query: 609 QSVPFLHWEAPVTSHSLTAREVM-----STPVTCLRRREKVGVIVDVLSDTASNHNGFPV 663
              PFL  +   T H   A +VM       P++ L +       V+ L    +++NGFPV
Sbjct: 579 NGYPFLDVKDEFT-HRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLI-KETDYNGFPV 636

Query: 664 VEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQS 723
           V   D     RL G   R +LI+ +K+     +   G+V   +    F +  P   P  S
Sbjct: 637 VVSRDS---ERLIGFAQRRELILAIKN---ARQRQEGIVSNSIMY--FTEEPPEL-PANS 687

Query: 724 IHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVT 783
            H         + L   +N SP+TV     +  V  +FR LGLR  +V     +++G++T
Sbjct: 688 PH--------PLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVT-RSGRLLGIIT 738

Query: 784 RKDLARY 790
           +KD+ R+
Sbjct: 739 KKDVLRH 745


>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
          Length = 818

 Score =  253 bits (645), Expect = 6e-67
 Identities = 211/723 (29%), Positives = 340/723 (47%), Gaps = 107/723 (14%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169
           W++  L G+ +G +A  IDI  + +  LK  +                N   F E+    
Sbjct: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188

Query: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
                           G    + +++     +F  +   +V    P A GSGIP+IK  L
Sbjct: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248

Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
           +G  I   +   TL+IK   ++L+V  GL++GKEGP++H         S          +
Sbjct: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298

Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
              +Y   + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++     WR FFA+++
Sbjct: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358

Query: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393
           + F L         ++    +  L+ F  +      + + E+  FI +GV GG+ GA F 
Sbjct: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408

Query: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452
             N  W    +     +    V+E ++VAA+TA +AF   Y+      L    +   L  
Sbjct: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461

Query: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508
            C   E +S+     +     +V    D P   G Y+ +      L++   +  +T+G+ 
Sbjct: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521

Query: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554
           V +G+FIPS+ IGA  GR+ GI++  L               + AD   PG YA++GAAA
Sbjct: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581

Query: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613
            LGG+ RMT+SL VI+ E T  + Y  P+M  +MT+K VGD F  EG+Y+ HI+L   PF
Sbjct: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641

Query: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667
           L  +   T H+  A +VM    + P   +  ++ + V  I +++++T  ++NGFPV+   
Sbjct: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696

Query: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727
              +  RL G  LR  L + ++      +   G+V        F    P  P        
Sbjct: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743

Query: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
             E    + L   ++ SP+TV     +  V  +FR LGLR  +V  N  +++G++T+KD+
Sbjct: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GRLLGIITKKDI 800

Query: 788 ARY 790
            R+
Sbjct: 801 LRH 803


>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
          Length = 866

 Score =  248 bits (634), Expect = 1e-65
 Identities = 210/723 (29%), Positives = 338/723 (46%), Gaps = 107/723 (14%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKG-------------NIDKFTEK---- 169
           W++  L G+ +G +A  IDI  + +  LK  +                N   F E+    
Sbjct: 129 WLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCP 188

Query: 170 ----------------GGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
                           G    + +++     +F  +   +V    P A GSGIP+IK  L
Sbjct: 189 QWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTIL 248

Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
           +G  I   +   TL+IK   ++L+V  GL++GKEGP++H         S          +
Sbjct: 249 SGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFS----------Y 298

Query: 274 KIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMI 333
              +Y   + +KR+ +SA +AAGVS AFGAP+GGVLFSLEE + ++     WR FFA+++
Sbjct: 299 LFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALV 358

Query: 334 STFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFN 393
           + F L         ++    +  L+ F  +      + + E+  FI +GV GG+ GA F 
Sbjct: 359 AAFVLR--------SINPFGNSRLVLF--YVEYHTPWYLFELFPFILLGVFGGLWGAFFI 408

Query: 394 ALNY-WLTMFRIRYIHRPCLQVIEAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQL 452
             N  W    +     +    V+E ++VAA+TA +AF   Y+      L    +   L  
Sbjct: 409 RANIAWCRRRKSTKFGK--YPVLEVIIVAAITAVIAFPNPYTR-----LNTSELIKELFT 461

Query: 453 FCADGEYNSMAAAFFNTPEKSVVSLFHDPP---GSYNPLTLGLFTLVY-FFLACWTYGLT 508
            C   E +S+     +     +V    D P   G Y+ +      L++   +  +T+G+ 
Sbjct: 462 DCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIK 521

Query: 509 VSAGVFIPSLLIGAAWGRLFGISLSYLT-----------GAAIWAD---PGKYALMGAAA 554
           V +G+FIPS+ IGA  GR+ GI++  L               + AD   PG YA++GAAA
Sbjct: 522 VPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAA 581

Query: 555 QLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPF 613
            LGG+ RMT+SL VI+ E T  + Y  P+M  +MT+K VGD F  EG+Y+ HI+L   PF
Sbjct: 582 CLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 641

Query: 614 LHWEAPVTSHSLTAREVM----STPVTCLRRREKVGV--IVDVLSDTASNHNGFPVVEHA 667
           L  +   T H+  A +VM    + P   +  ++ + V  I +++++T  ++NGFPV+   
Sbjct: 642 LDAKEEFT-HTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINET--SYNGFPVIM-- 696

Query: 668 DDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPPIQSIHVS 727
              +  RL G  LR  L + ++      +   G+V        F    P  P        
Sbjct: 697 -SKESQRLVGFALRRDLTIAIES---ARKKQEGIVGSSRVC--FAQHTPSLPA------- 743

Query: 728 QDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVGLVTRKDL 787
             E    + L   ++ SP+TV     +  V  +FR LGLR  +V  N   V+G++T+K++
Sbjct: 744 --ESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHN-GIVLGIITKKNI 800

Query: 788 ARY 790
             +
Sbjct: 801 LEH 803


>gi|156104869 chloride channel 2 [Homo sapiens]
          Length = 898

 Score =  191 bits (486), Expect = 2e-48
 Identities = 165/601 (27%), Positives = 277/601 (46%), Gaps = 60/601 (9%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLL----WATL 182
           W+   L+G+L  LV+  +D  +      +  + +G          L+ S+LL    W T 
Sbjct: 91  WIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRG----------LNTSILLQYLAWVTY 140

Query: 183 NAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGL 242
               +   +     + P A GSGIP++K  L GV +   + LKT + KV G+  ++  G+
Sbjct: 141 PVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGM 200

Query: 243 AVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFG 302
            +GKEGP +H  S+ AA +S+     L     I+E   R+TE    ++A  A GV   F 
Sbjct: 201 PLGKEGPFVHIASMCAALLSK----FLSLFGGIYENESRNTE---MLAAACAVGVGCCFA 253

Query: 303 APVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGR 362
           AP+GGVLFS+E  ++F+     WR FFA+  S F    VL++++ +   +++     F R
Sbjct: 254 APIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFR-VLAVWNRDEETITALFKTRF-R 311

Query: 363 FDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWL--TMFRIRYIHRPCL--QVIEAV 418
            D     + + E+P F  +G+  G  GA+F  LN  +   M + + I+R  +  +++   
Sbjct: 312 LD---FPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPA 368

Query: 419 LVAAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLF 478
           LV  + +T+ F   +          G +S    L         +        E    S  
Sbjct: 369 LVTLLISTLTFPPGFGQ-----FMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQA 423

Query: 479 HDPPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGA 538
            +PP +   LTL +F L+ F+++     + V  G F+P  +IGAA+GRL G S++     
Sbjct: 424 WNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPD 483

Query: 539 AIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAK 591
            I  D       PG YA++GAAA L G V  T+S  VI+ E T  + +  P+M+ ++ A 
Sbjct: 484 GIHTDSSTYRIVPGGYAVVGAAA-LAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILAN 542

Query: 592 IVGDVFIEGLYDMHIQLQSVPFL-------HWEAPVTSHSLTAREVMSTPVTCLRRREKV 644
            V       LYD  I+++ +P+L       H +  V    +  R+V    ++C  R  ++
Sbjct: 543 AVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRL 602

Query: 645 GVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQR 704
                     A +     ++   +  +   L G I RSQ++ LL  ++   R    + +R
Sbjct: 603 ----------ALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQER 652

Query: 705 R 705
           R
Sbjct: 653 R 653



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 19/86 (22%), Positives = 44/86 (51%), Gaps = 2/86 (2%)

Query: 705 RLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF-MNPSPYTVPQEASLPRVFKLFRA 763
           R+ L    D      P + +   + + +  ++ S+  ++P+P+ + +  SL +   +F  
Sbjct: 753 RISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSL 812

Query: 764 LGLRHLVVVDNRNQVVGLVTRKDLAR 789
           LG+ H   V +  +++G+VT K+L +
Sbjct: 813 LGVDH-AYVTSIGRLIGIVTLKELRK 837


>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
          Length = 988

 Score =  183 bits (464), Expect = 6e-46
 Identities = 161/583 (27%), Positives = 267/583 (45%), Gaps = 44/583 (7%)

Query: 127 WVICALIGILTGLVACFIDIV-VENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAA 185
           W+   L+G+L  LV+  +D V  ++L   K+   +        +  L    L+W T    
Sbjct: 118 WIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLV 170

Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG 245
            +L  ++    I P A GSGIP++K  L GV +   + +K  V KV  +   +  G+ VG
Sbjct: 171 LILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVG 230

Query: 246 KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPV 305
           KEGP +H  S+ AA +S+  S            + +     D ++ G A GV   FG P+
Sbjct: 231 KEGPFVHIASICAAVLSKFMSV-------FCGVYEQPYYYSDILTVGCAVGVGCCFGTPL 283

Query: 306 GGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDS 365
           GGVLFS+E  ++++     WR FFA+  S F    VL++++ +   +++    NF R D 
Sbjct: 284 GGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFR-VLAVWNKDAVTITALFRTNF-RMD- 340

Query: 366 EKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVI--EAVLVAAV 423
               + + E+P F A+G+  G+LGAVF  L+  + M  +R  H+   Q +    +L   +
Sbjct: 341 --FPFDLKELPAFAAIGICCGLLGAVFVYLHRQV-MLGVRK-HKALSQFLAKHRLLYPGI 396

Query: 424 TATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPG 483
              V     +     Q + G  M         D   N+        PE    S     P 
Sbjct: 397 VTFVIASFTFPPGMGQFMAGELMPREAISTLFD---NNTWVKHAGDPESLGQSAVWIHPR 453

Query: 484 SYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD 543
               + + LF ++ F+++     + +  G F+P  ++GAA+GRL G  ++ L    I  D
Sbjct: 454 VNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFD 513

Query: 544 -------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDV 596
                  PG YA++GAAA L G V  T+S  VI  E T  + +  P+M+ ++ A +V   
Sbjct: 514 DIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQS 572

Query: 597 FIEGLYDMHIQLQSVPF---LHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSD 653
               LYD  IQ++ +P+   L W   ++ +++   ++M   V  +      G +  +L  
Sbjct: 573 LQPSLYDSIIQVKKLPYLPDLGWN-QLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQT 631

Query: 654 TASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVER 696
           T       P+V+  D      L G + RS+L  LL+  +  ER
Sbjct: 632 TTV--KTLPLVDSKDS---MILLGSVERSELQALLQRHLCPER 669


>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
          Length = 308

 Score =  179 bits (453), Expect = 1e-44
 Identities = 93/189 (49%), Positives = 128/189 (67%), Gaps = 1/189 (0%)

Query: 94  YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
           YESLDYD   N  +LE    +++   R  E  +W++   IG+ TGLV  F+D  V     
Sbjct: 48  YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107

Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
           LK+ V++ ++++ ++KG L+ SLL     N  FV + S++V  IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166

Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
           NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++  
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226

Query: 274 KIFEYFRRD 282
             F YFR D
Sbjct: 227 FNFPYFRSD 235


>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
          Length = 320

 Score =  179 bits (453), Expect = 1e-44
 Identities = 93/189 (49%), Positives = 128/189 (67%), Gaps = 1/189 (0%)

Query: 94  YESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAG 153
           YESLDYD   N  +LE    +++   R  E  +W++   IG+ TGLV  F+D  V     
Sbjct: 48  YESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFFVRLFTQ 107

Query: 154 LKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFL 213
           LK+ V++ ++++ ++KG L+ SLL     N  FV + S++V  IEPVAAGSGIP++KC+L
Sbjct: 108 LKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LIEPVAAGSGIPEVKCYL 166

Query: 214 NGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDF 273
           NGVK+P +VRL+TL+ KV GV+ SV GGL VGKEGPMIHSGSV+ AG+ Q +S SL++  
Sbjct: 167 NGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVVGAGLPQFQSISLRKIQ 226

Query: 274 KIFEYFRRD 282
             F YFR D
Sbjct: 227 FNFPYFRSD 235


>gi|155969705 chloride channel Kb [Homo sapiens]
          Length = 687

 Score =  167 bits (422), Expect = 5e-41
 Identities = 172/690 (24%), Positives = 299/690 (43%), Gaps = 103/690 (14%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185
           W     +G+L  LV+C +D+ VE+       V++ +   + E G       L W     A
Sbjct: 50  WYFLMTLGVLMALVSCAMDLAVES-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102

Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243
            V   S     I P + GSGIP++K  L GV +   + +K    KV G+  ++  G  L 
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLF 162

Query: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303
           +GK GP +H   ++AA + + R+T++             +++ + + A AA GV+  F A
Sbjct: 163 LGKVGPFVHLSVMMAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215

Query: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363
           P  GVLFS+E  +S ++ +  WR FFA+    F    +L++++     ++S    +F R 
Sbjct: 216 PFSGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFR-LLAVFNSEQETITSLYKTSF-RV 273

Query: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVF-NALNYWLTMFRIRYIHRPCLQVIEAVLVAA 422
           D   + + + EI  F+A+G + G+LG+ +      +    R        L   + V  A 
Sbjct: 274 D---VPFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSAL 330

Query: 423 VTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPP 482
            T      L+ +S    P  G  ++  L +            + F+    ++++    PP
Sbjct: 331 AT------LVLASITYPPSAGRFLASRLSM-------KQHLDSLFDNHSWALMTQNSSPP 377

Query: 483 GS------------YNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWG 525
                         Y+P      TL  F ++ F++      + + AG F+P  + GAA G
Sbjct: 378 WPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIG 437

Query: 526 RLFGISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVT 578
           RLFG +LS++    I A        PG YAL GAAA   G V  T+S  ++  E T  + 
Sbjct: 438 RLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAA-FSGAVTHTISTALLAFEVTGQIV 496

Query: 579 YGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVT 636
           +  P+++ ++ A  +        YD  + ++ +P+L       + SH +     M+  +T
Sbjct: 497 HALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSIT 556

Query: 637 CLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVER 696
            L +   +  +V V+  T+++   +P+VE    T+   L G++ R+QL+  LK +     
Sbjct: 557 TLAKDMPLEEVVKVV--TSTDVAKYPLVE---STESQILVGIVRRAQLVQALKAEP---- 607

Query: 697 SNLGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPS-PYT--VPQEAS 753
                              P + P          ++C  D+     P+ P T  +  E S
Sbjct: 608 -------------------PSWAP--------GHQQCLQDILAAGCPTEPVTLKLSPETS 640

Query: 754 LPRVFKLFRALGLRHLVVVDNRNQVVGLVT 783
           L     LF  L L H + V +R + VG V+
Sbjct: 641 LHEAHNLFELLNL-HSLFVTSRGRAVGCVS 669


>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
          Length = 687

 Score =  147 bits (371), Expect = 4e-35
 Identities = 166/686 (24%), Positives = 292/686 (42%), Gaps = 95/686 (13%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185
           W     +G+L  LV+  ++  +         V++ +   + E G       L W     A
Sbjct: 50  WYFLMTLGVLMALVSYAMNFAIGC-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102

Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243
            V   S     I P + GSGIP++K  L GV +   + +K    KV G+  ++  G  L 
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162

Query: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303
           +GK GP +H   +IAA + + R+T++             +++ + + A AA GV+  F A
Sbjct: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215

Query: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363
           P  GVLFS+E  +S ++    WR FFA+    F    +L++++     ++S    +F R 
Sbjct: 216 PFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFR-LLAVFNSEQETITSLYKTSF-RV 273

Query: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMF--------RIRYIHRPCLQVI 415
           D   + + + EI  F+A+G + GVL   +         F        ++    +P    +
Sbjct: 274 D---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSAL 330

Query: 416 EAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL-QLFCADGEYNSMAAAFFNTPEKSV 474
             +L+A++T         +SR        SM   L  LF  D    ++     + P    
Sbjct: 331 ATLLLASITYPPGVGHFLASR-------LSMKQHLDSLF--DNHSWALMTQNSSPPWPEE 381

Query: 475 VSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG 529
           +   H     Y+P      TL  F ++ F++      + + AG F+P  ++GAA GRL G
Sbjct: 382 LDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLG 441

Query: 530 ISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFP 582
            +L+      I          PG YAL GAAA   G V  T+S  ++  E T  + +  P
Sbjct: 442 EALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALP 500

Query: 583 IMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRR 640
           +++ ++ A  +        YD  I ++ +P+L       + SH +     M+  +T L +
Sbjct: 501 VLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK 560

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLG 700
              +  +V V+  T+++   +P+VE    T+   L G++ R+QL+  L+ +         
Sbjct: 561 DTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQAE--------- 606

Query: 701 LVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEF---MNPSPYTVPQEASLPRV 757
                             PP +    +   ++C  D+        P   T+  E +L + 
Sbjct: 607 ------------------PPSR----APGHQQCLQDILARGCPTEPVTLTLFSETTLHQA 644

Query: 758 FKLFRALGLRHLVVVDNRNQVVGLVT 783
             LF+ L L+ L V  +R + VG V+
Sbjct: 645 QNLFKLLNLQSLFVT-SRGRAVGCVS 669


>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
          Length = 686

 Score =  146 bits (369), Expect = 7e-35
 Identities = 148/589 (25%), Positives = 260/589 (44%), Gaps = 60/589 (10%)

Query: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185
           W     +G+L  LV+  ++  +         V++ +   + E G       L W     A
Sbjct: 50  WYFLMTLGVLMALVSYAMNFAIGC-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102

Query: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243
            V   S     I P + GSGIP++K  L GV +   + +K    KV G+  ++  G  L 
Sbjct: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162

Query: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303
           +GK GP +H   +IAA + + R+T++             +++ + + A AA GV+  F A
Sbjct: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215

Query: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363
           P  GVLFS+E  +S ++    WR FFA+    F    +L++++     ++S    +F R 
Sbjct: 216 PFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFR-LLAVFNSEQETITSLYKTSF-RV 273

Query: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMF--------RIRYIHRPCLQVI 415
           D   + + + EI  F+A+G + GVL   +         F        ++    +P    +
Sbjct: 274 D---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSAL 330

Query: 416 EAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL-QLFCADGEYNSMAAAFFNTPEKSV 474
             +L+A++T         +SR        SM   L  LF  D    ++     + P    
Sbjct: 331 ATLLLASITYPPGVGHFLASR-------LSMKQHLDSLF--DNHSWALMTQNSSPPWPEE 381

Query: 475 VSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG 529
           +   H     Y+P      TL  F ++ F++      + + AG F+P  ++GAA GRL G
Sbjct: 382 LDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLG 441

Query: 530 ISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFP 582
            +L+      I          PG YAL GAAA   G V  T+S  ++  E T  + +  P
Sbjct: 442 EALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALP 500

Query: 583 IMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRR 640
           +++ ++ A  +        YD  I ++ +P+L       + SH +     M+  +T L +
Sbjct: 501 VLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK 560

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLK 689
              +  +V V+  T+++   +P+VE    T+   L G++ R+QL+  L+
Sbjct: 561 DTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQ 604


>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 4 isoform 1 [Homo
           sapiens]
          Length = 1834

 Score = 32.0 bits (71), Expect = 2.3
 Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 24/139 (17%)

Query: 446 MSYPLQLFCADGEYNSMAAAFFNTPEKS------VVSLFHDPPGSYN---------PLTL 490
           M++   + C   E N+   AF + PE++      +  + H   G+ +          LT+
Sbjct: 724 MAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTI 783

Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYAL- 549
            LF+ ++ F+  W +   V+      S L    WG +    L ++     WA+  K  L 
Sbjct: 784 QLFSQLFHFINMWLFNRLVTDP---DSGLCSHYWGAIIRQQLGHIEA---WAE--KQGLE 835

Query: 550 MGAAAQLGGIVRMTLSLTV 568
           + A   L  IV+ T  LT+
Sbjct: 836 LAADCHLSRIVQATTLLTM 854


>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 4 isoform 2 [Homo
           sapiens]
          Length = 1651

 Score = 32.0 bits (71), Expect = 2.3
 Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 24/139 (17%)

Query: 446 MSYPLQLFCADGEYNSMAAAFFNTPEKS------VVSLFHDPPGSYN---------PLTL 490
           M++   + C   E N+   AF + PE++      +  + H   G+ +          LT+
Sbjct: 725 MAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTI 784

Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYAL- 549
            LF+ ++ F+  W +   V+      S L    WG +    L ++     WA+  K  L 
Sbjct: 785 QLFSQLFHFINMWLFNRLVTDP---DSGLCSHYWGAIIRQQLGHIEA---WAE--KQGLE 836

Query: 550 MGAAAQLGGIVRMTLSLTV 568
           + A   L  IV+ T  LT+
Sbjct: 837 LAADCHLSRIVQATTLLTM 855


>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 4 isoform 3 [Homo
           sapiens]
          Length = 1612

 Score = 32.0 bits (71), Expect = 2.3
 Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 24/139 (17%)

Query: 446 MSYPLQLFCADGEYNSMAAAFFNTPEKS------VVSLFHDPPGSYN---------PLTL 490
           M++   + C   E N+   AF + PE++      +  + H   G+ +          LT+
Sbjct: 709 MAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTI 768

Query: 491 GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYAL- 549
            LF+ ++ F+  W +   V+      S L    WG +    L ++     WA+  K  L 
Sbjct: 769 QLFSQLFHFINMWLFNRLVTDP---DSGLCSHYWGAIIRQQLGHIEA---WAE--KQGLE 820

Query: 550 MGAAAQLGGIVRMTLSLTV 568
           + A   L  IV+ T  LT+
Sbjct: 821 LAADCHLSRIVQATTLLTM 839


>gi|18702331 OTU domain containing 7A [Homo sapiens]
          Length = 926

 Score = 32.0 bits (71), Expect = 2.3
 Identities = 21/68 (30%), Positives = 26/68 (38%)

Query: 27  TARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPDMDPPHPFPKEIPHN 86
           TA PGGG    + +GP   R  P  A   V H+ +    DE   P +    P       N
Sbjct: 742 TASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGALRPCATYPQQN 801

Query: 87  EKLLSLKY 94
             L S  Y
Sbjct: 802 RSLSSQSY 809


>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
          Length = 1858

 Score = 32.0 bits (71), Expect = 2.3
 Identities = 24/76 (31%), Positives = 30/76 (39%), Gaps = 18/76 (23%)

Query: 18   EEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLDPD---MD 74
            EE    L     PG G+ LL+GA P    ++P               +DE   P     D
Sbjct: 1433 EEMKCCLPDDGGPGAGSFLLHGASPPLLHRAP---------------EDEAAGPPGDACD 1477

Query: 75   PPHPFPKEIPHNEKLL 90
             P PFP  +PH   LL
Sbjct: 1478 IPPPFPNLLPHRPPLL 1493


>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


>gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]
          Length = 845

 Score = 31.2 bits (69), Expect = 4.0
 Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 2/99 (2%)

Query: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVF--VERSN 698
           RE   + ++ L    +++N    +E    ++  +L+ LIL   L++ L   VF  V  ++
Sbjct: 126 REDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTH 185

Query: 699 LGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDL 737
           L L   RL++  F         I  I + ++   CT DL
Sbjct: 186 LDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDL 224


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,442,108
Number of Sequences: 37866
Number of extensions: 1314243
Number of successful extensions: 4309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 4186
Number of HSP's gapped (non-prelim): 56
length of query: 805
length of database: 18,247,518
effective HSP length: 110
effective length of query: 695
effective length of database: 14,082,258
effective search space: 9787169310
effective search space used: 9787169310
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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