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Search of human proteins with 88703066
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|88703066 copine-like protein [Homo sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|88703066 copine-like protein [Homo sapiens] 1112 0.0
gi|25141323 copine V [Homo sapiens] 884 0.0
gi|25121972 copine VIII [Homo sapiens] 880 0.0
gi|4503015 copine III [Homo sapiens] 511 e-145
gi|30181236 copine II [Homo sapiens] 511 e-145
gi|18677733 copine IV [Homo sapiens] 497 e-140
gi|23397708 copine I isoform a [Homo sapiens] 493 e-139
gi|23397706 copine I isoform a [Homo sapiens] 493 e-139
gi|23397704 copine I isoform a [Homo sapiens] 493 e-139
gi|23397702 copine I isoform a [Homo sapiens] 493 e-139
gi|23397700 copine I isoform a [Homo sapiens] 493 e-139
gi|23397698 copine I isoform a [Homo sapiens] 493 e-139
gi|23397696 copine I isoform a [Homo sapiens] 493 e-139
gi|197333761 copine I isoform b [Homo sapiens] 493 e-139
gi|25141328 copine 7 isoform a [Homo sapiens] 480 e-135
gi|5174421 copine 6 [Homo sapiens] 467 e-131
gi|7656993 copine 7 isoform b [Homo sapiens] 399 e-111
gi|92859638 synaptotagmin V [Homo sapiens] 55 2e-07
gi|209447073 synaptotagmin I [Homo sapiens] 54 5e-07
gi|5032139 synaptotagmin I [Homo sapiens] 54 5e-07
gi|209447070 synaptotagmin I [Homo sapiens] 54 5e-07
gi|13384594 protein kinase C, gamma [Homo sapiens] 54 5e-07
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 50 4e-06
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 50 4e-06
gi|4506067 protein kinase C, alpha [Homo sapiens] 50 7e-06
gi|238550198 synaptotagmin III [Homo sapiens] 48 2e-05
gi|238550196 synaptotagmin III [Homo sapiens] 48 2e-05
gi|14150054 synaptotagmin III [Homo sapiens] 48 2e-05
gi|45504376 synaptotagmin VI [Homo sapiens] 48 2e-05
gi|28376627 synaptotagmin IX [Homo sapiens] 48 2e-05
>gi|88703066 copine-like protein [Homo sapiens]
Length = 553
Score = 1112 bits (2877), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MSLGGASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVID 60
MSLGGASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVID
Sbjct: 1 MSLGGASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVID 60
Query: 61 NTLNPDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSR 120
NTLNPDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSR
Sbjct: 61 NTLNPDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSR 120
Query: 121 VERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNED 180
VERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNED
Sbjct: 121 VERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNED 180
Query: 181 GTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTT 240
GTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTT
Sbjct: 181 GTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTT 240
Query: 241 SYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNF 300
SYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNF
Sbjct: 241 SYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNF 300
Query: 301 TVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLP 360
TVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLP
Sbjct: 301 TVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLP 360
Query: 361 PEGRISHQFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS 420
PEGRISHQFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS
Sbjct: 361 PEGRISHQFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS 420
Query: 421 DGSQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVS 480
DGSQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVS
Sbjct: 421 DGSQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVS 480
Query: 481 SRGRYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPP 540
SRGRYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPP
Sbjct: 481 SRGRYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPP 540
Query: 541 PANPSPIPAPEQP 553
PANPSPIPAPEQP
Sbjct: 541 PANPSPIPAPEQP 553
>gi|25141323 copine V [Homo sapiens]
Length = 593
Score = 884 bits (2283), Expect = 0.0
Identities = 430/567 (75%), Positives = 490/567 (86%), Gaps = 23/567 (4%)
Query: 10 SVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVR 69
S+PATK+EITVSCRNLLD D FSKSDP+ V+YTQ +++WREFGRTEVIDNTLNPDFVR
Sbjct: 19 SIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEVIDNTLNPDFVR 78
Query: 70 KFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLT--- 126
KF++DYFFEEKQNLRFD+Y+VDSK+ DFLGQAF LGE++G GSR+E+ LT
Sbjct: 79 KFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLGEIVGSPGSRLEKPLTIGA 138
Query: 127 -----------------GVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSD 169
GVPGKKCGTI+L+AEELSNCRD+ATMQ CANKLDKKDFFGKSD
Sbjct: 139 FSLNSRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVATMQFCANKLDKKDFFGKSD 198
Query: 170 PFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRD 229
PFLVFYRSNEDGTFTICHKTEV+KNTLNPVWQ FSIPVRALCNGDYDRT+K++VYDWDRD
Sbjct: 199 PFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALCNGDYDRTIKVEVYDWDRD 258
Query: 230 GSHDFIGEFTTSYRELSKAQNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFV 289
GSHDFIGEFTTSYREL++ Q+QF +YEV+NP+KK KKKKYVNSGTVTLLSF+V+SE TF+
Sbjct: 259 GSHDFIGEFTTSYRELARGQSQFNIYEVVNPKKKMKKKKYVNSGTVTLLSFAVESECTFL 318
Query: 290 DYIKGGTQLNFTVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKL 349
DYIKGGTQ+NFTVAIDFTASNGNP Q TSLHYMSPYQL+AYA+AL AVGEIIQ YDSDK+
Sbjct: 319 DYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYALALTAVGEIIQHYDSDKM 378
Query: 350 FPAYGFGAKLPPEGRISHQFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVI 409
FPA GFGAKLPP+GR+SH+FPLN N E+P+C GI+G+LE+Y +SLRTVQLYGPT FAPV+
Sbjct: 379 FPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYHRSLRTVQLYGPTNFAPVV 438
Query: 410 NQVARAAAKISDGSQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAM 469
VAR AA + DGSQY VLLIITDGVISDM QTKEAIV+A+ LPMSIIIVGVG A F+AM
Sbjct: 439 THVARNAAAVQDGSQYSVLLIITDGVISDMAQTKEAIVNAAKLPMSIIIVGVGQAEFDAM 498
Query: 470 EELDGDDVRVSSRGRYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYM 529
ELDGDDVR+SSRG+ AERDIVQFVPFRDYVDR+GN VLSMARLA+DVLAEIP+QL+SYM
Sbjct: 499 VELDGDDVRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMARLARDVLAEIPDQLVSYM 558
Query: 530 RTRDIQPRPPPPA---NPSPIPAPEQP 553
+ + I+PRPPP A +PS PA P
Sbjct: 559 KAQGIRPRPPPAAPTHSPSQSPARTPP 585
>gi|25121972 copine VIII [Homo sapiens]
Length = 564
Score = 880 bits (2275), Expect = 0.0
Identities = 420/538 (78%), Positives = 482/538 (89%), Gaps = 2/538 (0%)
Query: 10 SVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVR 69
++PAT++E++VSCRNLLD DTFSKSDP+ VLY Q ++EWREFGRTEVIDNTLNPDFVR
Sbjct: 20 AIPATRVEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVR 79
Query: 70 KFVLDYFFEEKQNLRFDVYNVDSKT-NISKPKDFLGQAFLALGEVIGGQGSRVERTLTGV 128
KF+LDYFFEE++NLRFD+Y+VDSK+ N+SK DFLGQ F LGE++G QGSR+E+ + G+
Sbjct: 80 KFILDYFFEERENLRFDLYDVDSKSPNLSK-HDFLGQVFCTLGEIVGSQGSRLEKPIVGI 138
Query: 129 PGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHK 188
PGKKCGTI+LTAEEL+ CRD MQ CANKLDKKDFFGKSDPFLVFYRSNEDG+FTICHK
Sbjct: 139 PGKKCGTIILTAEELNCCRDAVLMQFCANKLDKKDFFGKSDPFLVFYRSNEDGSFTICHK 198
Query: 189 TEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKA 248
TEVVKNTLNPVWQ F I VRALCNGDYDRT+K++VYDWDRDGSHDFIGEFTTSYRELS+
Sbjct: 199 TEVVKNTLNPVWQAFKISVRALCNGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELSRG 258
Query: 249 QNQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTA 308
Q+QF VYEV+NP+KK KKKKY NSGTVTLLSF V++E +F+DYIKGGTQ+NFTVAIDFTA
Sbjct: 259 QSQFNVYEVVNPKKKGKKKKYTNSGTVTLLSFLVETEVSFLDYIKGGTQINFTVAIDFTA 318
Query: 309 SNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQ 368
SNGNP QPTSLHYM+PYQL+AY MALKAVGEI+QDYDSDK+FPA GFGAKLPP+GRISH+
Sbjct: 319 SNGNPAQPTSLHYMNPYQLNAYGMALKAVGEIVQDYDSDKMFPALGFGAKLPPDGRISHE 378
Query: 369 FPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKISDGSQYYVL 428
F LN N ++P C GIEGV+E+Y++SL++VQLYGPT FAPVIN VAR A+ + DGSQY+VL
Sbjct: 379 FALNGNPQNPYCDGIEGVMEAYYRSLKSVQLYGPTNFAPVINHVARYASSVKDGSQYFVL 438
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSRGRYAER 488
LI+TDGVISDM QTKE+IV+AS LPMSIIIVGVGPA F+AM ELDGDDVRVSSRG+YAER
Sbjct: 439 LIVTDGVISDMAQTKESIVNASKLPMSIIIVGVGPAEFDAMVELDGDDVRVSSRGKYAER 498
Query: 489 DIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPANPSP 546
DIVQFVPFRDY+DRSGN +LSMARLAKDVLAEIPEQ LSYMR R I+P P PP P
Sbjct: 499 DIVQFVPFRDYIDRSGNHILSMARLAKDVLAEIPEQFLSYMRARGIKPSPAPPPYTPP 556
>gi|4503015 copine III [Homo sapiens]
Length = 537
Score = 511 bits (1317), Expect = e-145
Identities = 269/540 (49%), Positives = 367/540 (67%), Gaps = 23/540 (4%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
TK+ + VSC NLLD D SKSDP+ VL+ + + Q+W E RTE I N LNP F + F++
Sbjct: 7 TKVALNVSCANLLDKDIGSKSDPLCVLFLNT-SGQQWYEVERTERIKNCLNPQFSKTFII 65
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTL---TGVPG 130
DY+FE Q L+F VY++D+KT DFLG+ LG+++ + ++ R L TG P
Sbjct: 66 DYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSK--KLTRPLVMKTGRPA 123
Query: 131 KKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTE 190
K G+I ++AEE+ + R + ++ A KLD KD FGKSDP+L F++ DG + + H+TE
Sbjct: 124 GK-GSITISAEEIKDNR-VVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTE 181
Query: 191 VVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQN 250
VVKN LNPVW+PF I + +LC GD D+T+K++ YD+D DGSHD IG F T+ +L +A
Sbjct: 182 VVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEASR 241
Query: 251 QFTV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTAS 309
V +E +N +K+ KKK Y NSG +++ + E TF+DYI GG QLNFTV +DFT S
Sbjct: 242 SSPVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGS 301
Query: 310 NGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQF 369
NG+P P SLHY+SP ++ Y AL +VG +IQDYD+DK+FPA+GFGA++PP+ ++SH+F
Sbjct: 302 NGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEF 361
Query: 370 PLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVAR---AAAKISDGSQYY 426
P+N N +P C GI+G++E+Y L ++LYGPT F+P+IN VAR AA + SQY+
Sbjct: 362 PMNFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQYF 421
Query: 427 VLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRV-SSRGRY 485
VLLIITDGVI+D+ +T++AIV+AS LPMSIIIVGVG A F AME LDGD + S G
Sbjct: 422 VLLIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGEV 481
Query: 486 AERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPANPS 545
A RDIVQFVPFR + Q LA+ VLAEIP+Q++ Y T + PP NP+
Sbjct: 482 AIRDIVQFVPFRQF------QNAPKEALAQCVLAEIPQQVVGYFNTYKLL----PPKNPA 531
>gi|30181236 copine II [Homo sapiens]
Length = 548
Score = 511 bits (1316), Expect = e-145
Identities = 262/535 (48%), Positives = 371/535 (69%), Gaps = 18/535 (3%)
Query: 15 KIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLD 74
K+E++VS +NLLD D SKSDP VL+T++ W E+ RTE N LNP F +KFVLD
Sbjct: 25 KVELSVSGQNLLDRDVTSKSDPFCVLFTENNG--RWIEYDRTETAINNLNPAFSKKFVLD 82
Query: 75 YFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKCG 134
Y FEE Q L+F +++ D + DFLGQ +LG ++ + ++ R L + K G
Sbjct: 83 YHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSK--KITRPLLLLNDKPAG 140
Query: 135 TILLT--AEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVV 192
L+T A+ELS+ R + T+ L +LDKKD FGKSDPFL FY+ +DG + + H+TEV+
Sbjct: 141 KGLITIAAQELSDNR-VITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVI 199
Query: 193 KNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQF 252
K TL+PVW+PF++P+ +LC+GD ++ +++ YD+D DG HDFIGEF TS ++ +A++
Sbjct: 200 KYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSV 259
Query: 253 TV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
+ +E +NP+K+ KKK Y NSG + L S ++ +++F+DYI GG QL FTV IDFTASNG
Sbjct: 260 PLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNG 319
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
NPL P+SLHY++P + Y A+ AVG+IIQDYDSDK+FPA GFGA+LPP+ ++SH+F +
Sbjct: 320 NPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAI 379
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKISD---GSQYYVL 428
N N +P C+G++G+ ++Y L ++ YGPT F+P++N VAR AA+ + +QY++L
Sbjct: 380 NFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFIL 439
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
LIITDGVISDM +T+ A+V AS LPMSIIIVGVG A F AME LDGD + S G A
Sbjct: 440 LIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAA 499
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPA 542
RDIVQFVPFR++ + + LAK VLAE+P+Q++ Y + +++ P PA
Sbjct: 500 RDIVQFVPFREF------RNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA 548
>gi|18677733 copine IV [Homo sapiens]
Length = 557
Score = 497 bits (1279), Expect = e-140
Identities = 262/532 (49%), Positives = 355/532 (66%), Gaps = 20/532 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
TK+E+ V+C+ + D D SK DP V+L QS +W E RTEVI +NP + + F +
Sbjct: 24 TKVELRVACKGISDRDALSKPDPCVILKMQSHG--QWFEVDRTEVIRTCINPVYSKLFTV 81
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLT---GVPG 130
D++FEE Q LRF+V+++ S N K DFLG LG+++ + ++ ++L G
Sbjct: 82 DFYFEEVQRLRFEVHDISSNHNGLKEADFLGGMECTLGQIVSQR--KLSKSLLKHGNTAG 139
Query: 131 KKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTE 190
K T++ AEELS D + A KLD KDFF KSDPFL +R N+D T + H+TE
Sbjct: 140 KSSITVI--AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQQLVHRTE 197
Query: 191 VVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQN 250
VV N L+P W+ F + V +LC+GD DR +K V+DWD +G HDFIGEFT++++E+ A
Sbjct: 198 VVMNNLSPAWKSFKVSVNSLCSGDPDRRLKCIVWDWDSNGKHDFIGEFTSTFKEMRGAME 257
Query: 251 QFTV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTAS 309
V +E +NP+ K KKK Y NSGTV L + +F+DYI GG Q+ FTVAIDFTAS
Sbjct: 258 GKQVQWECINPKYKAKKKNYKNSGTVILNLCKIHKMHSFLDYIMGGCQIQFTVAIDFTAS 317
Query: 310 NGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQF 369
NG+P SLHY+ PYQ + Y AL AVGEI QDYDSDK+FPA+GFGA++PPE +SH F
Sbjct: 318 NGDPRNSCSLHYIHPYQPNEYLKALVAVGEICQDYDSDKMFPAFGFGARIPPEYTVSHDF 377
Query: 370 PLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAK---ISDGSQYY 426
+N N+++P CAGI+GV+E+Y L +QLYGPT AP+I +VA++A++ + SQY+
Sbjct: 378 AINFNEDNPECAGIQGVVEAYQSCLPKLQLYGPTNIAPIIQKVAKSASEETNTKEASQYF 437
Query: 427 VLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDD-VRVSSRGRY 485
+LLI+TDGVI+DM T+EAIV AS LPMS+IIVGVG A F M+ LDGDD + S +G
Sbjct: 438 ILLILTDGVITDMADTREAIVHASHLPMSVIIVGVGNADFSDMQMLDGDDGILRSPKGEP 497
Query: 486 AERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPR 537
RDIVQFVPFR++ + S A LAK VLAE+P Q++ Y + I+P+
Sbjct: 498 VLRDIVQFVPFRNF------KHASPAALAKSVLAEVPNQVVDYYNGKGIKPK 543
Score = 34.7 bits (78), Expect = 0.23
Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 6 ASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNP 65
A E S +E+ + R L D D FSKSDP + ++ + + + + RTEV+ N L+P
Sbjct: 147 AEELSGNDDYVELAFNARKLDDKDFFSKSDPFLEIFRMNDDATQ-QLVHRTEVVMNNLSP 205
>gi|23397708 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|23397706 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|23397704 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|23397702 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|23397700 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|23397698 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|23397696 copine I isoform a [Homo sapiens]
Length = 537
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 6 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 64
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 65 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 122
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 123 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 180
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 181 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 240
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 241 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 297
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 298 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 357
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 358 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 417
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 418 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 477
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 478 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 531
Query: 547 IPAPE 551
AP+
Sbjct: 532 AQAPQ 536
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 1 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 57
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 58 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 110
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 111 TLPLMLKPGKPAGRGTITV 129
>gi|197333761 copine I isoform b [Homo sapiens]
Length = 542
Score = 493 bits (1269), Expect = e-139
Identities = 259/545 (47%), Positives = 368/545 (67%), Gaps = 21/545 (3%)
Query: 14 TKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
T +++++SC +L+D D SKSDP+ VL Q W E GRTE + N +P+F + L
Sbjct: 11 TLVQLSISCDHLIDKDIGSKSDPLCVLL-QDVGGGSWAELGRTERVRNCSSPEFSKTLQL 69
Query: 74 DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133
+Y FE Q LRF +Y++D+KT + DFLG A +LG+++ Q + L PGK
Sbjct: 70 EYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLK--PGKPA 127
Query: 134 G--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEV 191
G TI ++A+EL + R + TM++ A LDKKDF GKSDPFL F+R DG + + +++EV
Sbjct: 128 GRGTITVSAQELKDNR-VVTMEVEARNLDKKDFLGKSDPFLEFFRQG-DGKWHLVYRSEV 185
Query: 192 VKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
+KN LNP W+ FS+PV+ C G+ +++ D+D DGSHD IG F TS +L +
Sbjct: 186 IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE 245
Query: 252 FTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTASNG 311
F E ++P K+ KKK Y NSGT+ + V++E++F+DY+ GG Q+NFTV +DFT SNG
Sbjct: 246 F---ECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNG 302
Query: 312 NPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQFPL 371
+P P SLHY+SP ++ Y MAL +VG ++QDYDSDKLFPA+GFGA++PP+ ++SH+F L
Sbjct: 303 DPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFAL 362
Query: 372 NNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAKIS---DGSQYYVL 428
N N +P CAGI+G++++Y Q+L V+LYGPT FAP+IN VAR AA+ + SQY++L
Sbjct: 363 NFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFML 422
Query: 429 LIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRVSSR-GRYAE 487
L++TDG ++D+ T+EA+V AS+LPMS+IIVGVG A FEAME+LD D + +R G+ A
Sbjct: 423 LLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAA 482
Query: 488 RDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQP-RPPPPANPSP 546
RDIVQFVP+R + Q LA+ VLAE+P QL+SY R + P +P PP+ P
Sbjct: 483 RDIVQFVPYRRF------QNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDP 536
Query: 547 IPAPE 551
AP+
Sbjct: 537 AQAPQ 541
Score = 34.7 bits (78), Expect = 0.23
Identities = 32/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
+++C + + + + L KD KSDP V + G++ +TE V+N +P
Sbjct: 6 MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSP---E 62
Query: 203 FSIPVRALCNGDYDRTVKIDVYDWDRD----GSHDFIGEFTTSYRELSKAQNQFTVYEVL 258
FS ++ + + ++ +YD D DF+G S ++ +Q VL
Sbjct: 63 FSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQ-------VL 115
Query: 259 NPRKKCKKKKYVNSGTVTL 277
K K GT+T+
Sbjct: 116 TLPLMLKPGKPAGRGTITV 134
>gi|25141328 copine 7 isoform a [Homo sapiens]
Length = 558
Score = 480 bits (1236), Expect = e-135
Identities = 268/548 (48%), Positives = 359/548 (65%), Gaps = 22/548 (4%)
Query: 13 ATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFV 72
A+K+E+ +SCR+LLD D +KSDP V L Q++ +W + GRTEV+ ++L+P F + F
Sbjct: 21 ASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQG--QWVQVGRTEVVRSSLHPVFSKVFT 78
Query: 73 LDYFFEEKQNLRFDVYNVDSKTNIS-KPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGK 131
+DY+FEE Q LRF+VY+ + S + DFLG LG+++ + +V R L G+
Sbjct: 79 VDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQIVAQK--KVTRPLLLKFGR 136
Query: 132 KCG--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKT 189
G TI + AE++S + A KLD KD F KSDPFL YR N+D + ++T
Sbjct: 137 NAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRVNDDQGLQLVYRT 196
Query: 190 EVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQ 249
EVVKN LNPVW+ F + + +LC+ + R +K V+D+D G HDFIGEF+T++ E+ KA
Sbjct: 197 EVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGEFSTTFEEMQKAF 256
Query: 250 NQFTV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFTA 308
+ ++ +NP+ K K++ Y NSG V L ++F+DYI GG Q++FTVAIDFTA
Sbjct: 257 EEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGCQIHFTVAIDFTA 316
Query: 309 SNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISHQ 368
SNG+P SLHY++PYQ + Y AL +VGEI QDYDSDK F A GFGA++PP+ +SH
Sbjct: 317 SNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFGARIPPKYEVSHD 376
Query: 369 FPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVAR-AAAKISDG--SQY 425
F +N N ED C GI+GV+E+Y L VQLYGPT AP+I++VAR AAA+ S G SQY
Sbjct: 377 FAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVAAAEESTGKASQY 436
Query: 426 YVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDD-VRVSSRGR 484
Y+LLI+TDGV++DM T+EAIV AS LPMSIIIVGVG A F M+ LDGDD V S RG
Sbjct: 437 YILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLDGDDGVLRSPRGE 496
Query: 485 YAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPR----PPP 540
A RDIVQFVPFR+ + S A LAK VLAE+P+Q++ Y R + PR P
Sbjct: 497 PALRDIVQFVPFRELKN------ASPAALAKCVLAEVPKQVVEYYSHRGLPPRSLGVPAG 550
Query: 541 PANPSPIP 548
A+P P
Sbjct: 551 EASPGCTP 558
>gi|5174421 copine 6 [Homo sapiens]
Length = 557
Score = 467 bits (1202), Expect = e-131
Identities = 255/547 (46%), Positives = 346/547 (63%), Gaps = 19/547 (3%)
Query: 13 ATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFV 72
A+++E+ VSC LLD DT +K P V+L S ++W E RTEV+ + +P F R
Sbjct: 19 ASRVELRVSCHGLLDRDTLTKPHPCVLLKLYS--DEQWVEVERTEVLRSCSSPVFSRVLA 76
Query: 73 LDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKK 132
L+YFFEEKQ L+F V++ + + FLG LG+++ ++V + L GK
Sbjct: 77 LEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQ--TKVTKPLLLKNGKT 134
Query: 133 CG--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTE 190
G TI + AEE+S D + A KLD KD F KSDPF+ Y++NED + + +TE
Sbjct: 135 AGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTE 194
Query: 191 VVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQ- 249
VVKN LNP W+PF + + +LC+ D R +K VYD+D G HDFIGEFT++++E+ +
Sbjct: 195 VVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTA 254
Query: 250 --NQFTVYEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGTQLNFTVAIDFT 307
Q ++ +NP+ + KKK Y +SGTV L +V+ TF+DYI GG Q++FTVAIDFT
Sbjct: 255 NPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFT 314
Query: 308 ASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFGAKLPPEGRISH 367
ASNG+P SLH +SP Q + Y AL+AVG I QDYDSDK FPA+GFGA++PP +SH
Sbjct: 315 ASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSH 374
Query: 368 QFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVARAAAK---ISDGSQ 424
F +N + E+P C I GV+ SY + L +QLYGPT AP+IN+VA A + ++
Sbjct: 375 DFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATK 434
Query: 425 YYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELDGDDVRV-SSRG 483
Y VLL++TDGV+SDM +T+ AIV AS LPMSIIIVGVG A F M LDGDD + RG
Sbjct: 435 YSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRG 494
Query: 484 RYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTRDIQPRPPPPAN 543
A RDIVQFVPFRD+ D + + LAK VLAE+P Q++ Y ++ I P P P
Sbjct: 495 VPAARDIVQFVPFRDFKD------AAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCT 548
Query: 544 PSPIPAP 550
+ P+P
Sbjct: 549 LATTPSP 555
Score = 40.0 bits (92), Expect = 0.006
Identities = 34/104 (32%), Positives = 51/104 (49%), Gaps = 10/104 (9%)
Query: 6 ASERSVPATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNP 65
A E S +++T L + D FSKSDP + +Y ++ Q + RTEV+ N LNP
Sbjct: 144 AEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIY-KTNEDQSDQLVWRTEVVKNNLNP 202
Query: 66 DFVRKFVLDYF----FEEKQNLRFDVYNVDSKTNISKPKDFLGQ 105
+ F L + + L+F VY+ DS S DF+G+
Sbjct: 203 SW-EPFRLSLHSLCSCDVHRPLKFLVYDYDS----SGKHDFIGE 241
>gi|7656993 copine 7 isoform b [Homo sapiens]
Length = 633
Score = 399 bits (1026), Expect = e-111
Identities = 223/440 (50%), Positives = 289/440 (65%), Gaps = 17/440 (3%)
Query: 120 RVERTLTGVPGKKCG--TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRS 177
+V R L G+ G TI + AE++S + A KLD KD F KSDPFL YR
Sbjct: 200 KVTRPLLLKFGRNAGKSTITVIAEDISGNNGYVELSFRARKLDDKDLFSKSDPFLELYRV 259
Query: 178 NEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGE 237
N+D + ++TEVVKN LNPVW+ F + + +LC+ + R +K V+D+D G HDFIGE
Sbjct: 260 NDDQGLQLVYRTEVVKNNLNPVWEAFKVSLSSLCSCEETRPLKCLVWDYDSRGKHDFIGE 319
Query: 238 FTTSYRELSKAQNQFTV-YEVLNPRKKCKKKKYVNSGTVTLLSFSVDSEFTFVDYIKGGT 296
F+T++ E+ KA + ++ +NP+ K K++ Y NSG V L ++F+DYI GG
Sbjct: 320 FSTTFEEMQKAFEEGQAQWDCVNPKYKQKRRSYKNSGVVVLADLKFHRVYSFLDYIMGGC 379
Query: 297 QLNFTVAIDFTASNGNPLQPTSLHYMSPYQLSAYAMALKAVGEIIQDYDSDKLFPAYGFG 356
Q++FTVAIDFTASNG+P SLHY++PYQ + Y AL +VGEI QDYDSDK F A GFG
Sbjct: 380 QIHFTVAIDFTASNGDPRNSCSLHYINPYQPNEYLKALVSVGEICQDYDSDKRFSALGFG 439
Query: 357 AKLPPEGRISHQFPLNNNDEDPNCAGIEGVLESYFQSLRTVQLYGPTYFAPVINQVAR-A 415
A++PP+ +SH F +N N ED C GI+GV+E+Y L VQLYGPT AP+I++VAR A
Sbjct: 440 ARIPPKYEVSHDFAINFNPEDDECEGIQGVVEAYQNCLPRVQLYGPTNVAPIISKVARVA 499
Query: 416 AAKISDG--SQYYVLLIITDGVISDMTQTKEAIVSASSLPMSIIIVGVGPAMFEAMEELD 473
AA+ S G SQYY+LLI+TDGV++DM T+EAIV AS LPMSIIIVGVG A F M+ LD
Sbjct: 500 AAEESTGKASQYYILLILTDGVVTDMADTREAIVRASRLPMSIIIVGVGNADFTDMQVLD 559
Query: 474 GDD-VRVSSRGRYAERDIVQFVPFRDYVDRSGNQVLSMARLAKDVLAEIPEQLLSYMRTR 532
GDD V S RG A RDIVQFVPFR+ + S A LAK VLAE+P+Q++ Y R
Sbjct: 560 GDDGVLRSPRGEPALRDIVQFVPFRELKN------ASPAALAKCVLAEVPKQVVEYYSHR 613
Query: 533 DIQPR----PPPPANPSPIP 548
+ PR P A+P P
Sbjct: 614 GLPPRSLGVPAGEASPGCTP 633
Score = 88.6 bits (218), Expect = 1e-17
Identities = 45/101 (44%), Positives = 67/101 (66%), Gaps = 3/101 (2%)
Query: 13 ATKIEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFV 72
A+K+E+ +SCR+LLD D +KSDP V L Q++ +W + GRTEV+ ++L+P F + F
Sbjct: 21 ASKVELRLSCRHLLDRDPLTKSDPSVALLQQAQG--QWVQVGRTEVVRSSLHPVFSKVFT 78
Query: 73 LDYFFEEKQNLRFDVYNVDSKTNIS-KPKDFLGQAFLALGE 112
+DY+FEE Q LRF+VY+ + S + DFLG LG+
Sbjct: 79 VDYYFEEVQRLRFEVYDTHGPSGFSCQEDDFLGGMECTLGQ 119
Score = 39.7 bits (91), Expect = 0.007
Identities = 33/93 (35%), Positives = 48/93 (51%), Gaps = 8/93 (8%)
Query: 16 IEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDF-VRKFVLD 74
+E++ R L D D FSKSDP + LY + Q + RTEV+ N LNP + K L
Sbjct: 232 VELSFRARKLDDKDLFSKSDPFLELY-RVNDDQGLQLVYRTEVVKNNLNPVWEAFKVSLS 290
Query: 75 YF--FEEKQNLRFDVYNVDSKTNISKPKDFLGQ 105
EE + L+ V++ DS+ DF+G+
Sbjct: 291 SLCSCEETRPLKCLVWDYDSRGK----HDFIGE 319
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/218 (27%), Positives = 92/218 (42%), Gaps = 17/218 (7%)
Query: 25 LLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEEKQN-- 82
L LD SDP V +Y + + T+V TLNP F F + E
Sbjct: 135 LAALDLGGSSDPYVRVYLLPDKRRRYE----TKVHRQTLNPHFGETFAFKVPYVELGGRV 190
Query: 83 LRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGK---KCGTILLT 139
L VY+ D + D +G+ + + V G+ + R L P + K G I +
Sbjct: 191 LVMAVYDFDRFSR----NDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFS 246
Query: 140 AEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPV 199
+ + + L A L K D G SDP++ + + G KT + KNTLNP
Sbjct: 247 LRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLL-QGGKKVRKKKTTIKKNTLNPY 305
Query: 200 W-QPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIG 236
+ + FS V C+ V++ V D+D+ G ++ IG
Sbjct: 306 YNEAFSFEVP--CDQVQKVQVELTVLDYDKLGKNEAIG 341
Score = 31.2 bits (69), Expect = 2.6
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 6/76 (7%)
Query: 163 DFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVW-QPFSIPVRALCNGDYDRTVKI 221
D G SDP++ Y + ++T+V + TLNP + + F+ V + G R + +
Sbjct: 139 DLGGSSDPYVRVYLLPDKRRR---YETKVHRQTLNPHFGETFAFKVPYVELGG--RVLVM 193
Query: 222 DVYDWDRDGSHDFIGE 237
VYD+DR +D IGE
Sbjct: 194 AVYDFDRFSRNDAIGE 209
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 53.5 bits (127), Expect = 5e-07
Identities = 64/251 (25%), Positives = 104/251 (41%), Gaps = 22/251 (8%)
Query: 20 VSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEE 79
+ L LD SDP V ++ +++ T+V TLNP F +F + E
Sbjct: 164 IQAAELPALDMGGTSDPYVKVFLLPDKKKKFE----TKVHRKTLNPVFNEQFTFKVPYSE 219
Query: 80 K--QNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGK---KCG 134
+ L VY+ D SK D +G+ + + V G + R L + K G
Sbjct: 220 LGGKTLVMAVYDFD---RFSK-HDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLG 275
Query: 135 TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKN 194
I + + + + L A L K D G SDP++ + ++G KT + KN
Sbjct: 276 DICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKN 334
Query: 195 TLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
TLNP + F +P + V + V D+D+ G +D IG+ Y + A+ +
Sbjct: 335 TLNPYYNESFSFEVPFEQIQKVQ----VVVTVLDYDKIGKNDAIGKVFVGYNS-TGAELR 389
Query: 252 FTVYEVLNPRK 262
+ NPR+
Sbjct: 390 HWSDMLANPRR 400
Score = 33.5 bits (75), Expect = 0.52
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 7 SERSVP-ATKIEITV-SCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLN 64
S R VP A K+ + + +NL +D SDP V ++ + ++ +T + NTLN
Sbjct: 280 SLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKK--KTTIKKNTLN 337
Query: 65 PDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFL 108
P + F + FE+ Q ++ V V I K D +G+ F+
Sbjct: 338 PYYNESFSFEVPFEQIQKVQV-VVTVLDYDKIGK-NDAIGKVFV 379
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 53.5 bits (127), Expect = 5e-07
Identities = 64/251 (25%), Positives = 104/251 (41%), Gaps = 22/251 (8%)
Query: 20 VSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEE 79
+ L LD SDP V ++ +++ T+V TLNP F +F + E
Sbjct: 164 IQAAELPALDMGGTSDPYVKVFLLPDKKKKFE----TKVHRKTLNPVFNEQFTFKVPYSE 219
Query: 80 K--QNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGK---KCG 134
+ L VY+ D SK D +G+ + + V G + R L + K G
Sbjct: 220 LGGKTLVMAVYDFD---RFSK-HDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLG 275
Query: 135 TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKN 194
I + + + + L A L K D G SDP++ + ++G KT + KN
Sbjct: 276 DICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKN 334
Query: 195 TLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
TLNP + F +P + V + V D+D+ G +D IG+ Y + A+ +
Sbjct: 335 TLNPYYNESFSFEVPFEQIQKVQ----VVVTVLDYDKIGKNDAIGKVFVGYNS-TGAELR 389
Query: 252 FTVYEVLNPRK 262
+ NPR+
Sbjct: 390 HWSDMLANPRR 400
Score = 33.5 bits (75), Expect = 0.52
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 7 SERSVP-ATKIEITV-SCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLN 64
S R VP A K+ + + +NL +D SDP V ++ + ++ +T + NTLN
Sbjct: 280 SLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKK--KTTIKKNTLN 337
Query: 65 PDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFL 108
P + F + FE+ Q ++ V V I K D +G+ F+
Sbjct: 338 PYYNESFSFEVPFEQIQKVQV-VVTVLDYDKIGK-NDAIGKVFV 379
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 53.5 bits (127), Expect = 5e-07
Identities = 64/251 (25%), Positives = 104/251 (41%), Gaps = 22/251 (8%)
Query: 20 VSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEE 79
+ L LD SDP V ++ +++ T+V TLNP F +F + E
Sbjct: 164 IQAAELPALDMGGTSDPYVKVFLLPDKKKKFE----TKVHRKTLNPVFNEQFTFKVPYSE 219
Query: 80 K--QNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGK---KCG 134
+ L VY+ D SK D +G+ + + V G + R L + K G
Sbjct: 220 LGGKTLVMAVYDFD---RFSK-HDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLG 275
Query: 135 TILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKN 194
I + + + + L A L K D G SDP++ + ++G KT + KN
Sbjct: 276 DICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLM-QNGKRLKKKKTTIKKN 334
Query: 195 TLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKAQNQ 251
TLNP + F +P + V + V D+D+ G +D IG+ Y + A+ +
Sbjct: 335 TLNPYYNESFSFEVPFEQIQKVQ----VVVTVLDYDKIGKNDAIGKVFVGYNS-TGAELR 389
Query: 252 FTVYEVLNPRK 262
+ NPR+
Sbjct: 390 HWSDMLANPRR 400
Score = 33.5 bits (75), Expect = 0.52
Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 7 SERSVP-ATKIEITV-SCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLN 64
S R VP A K+ + + +NL +D SDP V ++ + ++ +T + NTLN
Sbjct: 280 SLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKK--KTTIKKNTLN 337
Query: 65 PDFVRKFVLDYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFL 108
P + F + FE+ Q ++ V V I K D +G+ F+
Sbjct: 338 PYYNESFSFEVPFEQIQKVQV-VVTVLDYDKIGK-NDAIGKVFV 379
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 53.5 bits (127), Expect = 5e-07
Identities = 35/93 (37%), Positives = 46/93 (49%), Gaps = 3/93 (3%)
Query: 156 ANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDY 215
A L D G SDP++ + T KT VK TLNPVW V L GD
Sbjct: 180 ARNLIPMDPNGLSDPYVKLKLIPDPRNLTK-QKTRTVKATLNPVWNETF--VFNLKPGDV 236
Query: 216 DRTVKIDVYDWDRDGSHDFIGEFTTSYRELSKA 248
+R + ++V+DWDR +DF+G + EL KA
Sbjct: 237 ERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKA 269
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 50.4 bits (119), Expect = 4e-06
Identities = 63/249 (25%), Positives = 102/249 (40%), Gaps = 56/249 (22%)
Query: 23 RNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEEKQN 82
R+L +D+ SDP Y + R + +++++ TLNP + +F D+ E++
Sbjct: 259 RDLKAMDSNGLSDP----YVKFRLGHQKY---KSKIMPKTLNPQWREQF--DFHLYEERG 309
Query: 83 LRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKCGTILLTA-- 140
D+ D + K DF+G+ + L + Q ++E L G + LTA
Sbjct: 310 GVIDITAWDK--DAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASA 367
Query: 141 ------------------EEL----------SNCRDIATMQ---LCANKLDKKDFFGKSD 169
EE+ N +D+ +Q + A L D GKSD
Sbjct: 368 TVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSD 427
Query: 170 PFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP-FSIPVRALCNGDYDRTVKIDVYDWDR 228
PF V +N+ T V LNP W F+ ++ D +++ VYD DR
Sbjct: 428 PFCVVELNNDRLL------THTVYKNLNPEWNKVFTFNIK-----DIHSVLEVTVYDEDR 476
Query: 229 DGSHDFIGE 237
D S DF+G+
Sbjct: 477 DRSADFLGK 485
Score = 35.4 bits (80), Expect = 0.14
Identities = 30/107 (28%), Positives = 48/107 (44%), Gaps = 16/107 (14%)
Query: 147 RDIATMQLCANK-LDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVW-QPFS 204
R I ++ L + L D G SDP++ F ++ +K++++ TLNP W + F
Sbjct: 248 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQK------YKSKIMPKTLNPQWREQFD 301
Query: 205 IPVRALCNGDYDRTVKIDVYDWDRDGS--HDFIGEFTTSYRELSKAQ 249
+ +R ID+ WD+D DFIG LS+ Q
Sbjct: 302 FHLYE------ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ 342
Score = 30.0 bits (66), Expect = 5.8
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 11/79 (13%)
Query: 159 LDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDR- 217
L +D G SDP++ F ++ +++++ LNPVW+ +A D+ R
Sbjct: 52 LAARDRGGTSDPYVKFKIGGKE-----VFRSKIIHKNLNPVWEE-----KACILVDHLRE 101
Query: 218 TVKIDVYDWDRDGSHDFIG 236
+ I V+D+D DF+G
Sbjct: 102 PLYIKVFDYDFGLQDDFMG 120
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 50.4 bits (119), Expect = 4e-06
Identities = 63/249 (25%), Positives = 102/249 (40%), Gaps = 56/249 (22%)
Query: 23 RNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEEKQN 82
R+L +D+ SDP Y + R + +++++ TLNP + +F D+ E++
Sbjct: 480 RDLKAMDSNGLSDP----YVKFRLGHQKY---KSKIMPKTLNPQWREQF--DFHLYEERG 530
Query: 83 LRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKCGTILLTA-- 140
D+ D + K DF+G+ + L + Q ++E L G + LTA
Sbjct: 531 GVIDITAWDK--DAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASA 588
Query: 141 ------------------EEL----------SNCRDIATMQ---LCANKLDKKDFFGKSD 169
EE+ N +D+ +Q + A L D GKSD
Sbjct: 589 TVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSD 648
Query: 170 PFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP-FSIPVRALCNGDYDRTVKIDVYDWDR 228
PF V +N+ T V LNP W F+ ++ D +++ VYD DR
Sbjct: 649 PFCVVELNNDRLL------THTVYKNLNPEWNKVFTFNIK-----DIHSVLEVTVYDEDR 697
Query: 229 DGSHDFIGE 237
D S DF+G+
Sbjct: 698 DRSADFLGK 706
Score = 35.4 bits (80), Expect = 0.14
Identities = 30/107 (28%), Positives = 48/107 (44%), Gaps = 16/107 (14%)
Query: 147 RDIATMQLCANK-LDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVW-QPFS 204
R I ++ L + L D G SDP++ F ++ +K++++ TLNP W + F
Sbjct: 469 RGIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQK------YKSKIMPKTLNPQWREQFD 522
Query: 205 IPVRALCNGDYDRTVKIDVYDWDRDGS--HDFIGEFTTSYRELSKAQ 249
+ +R ID+ WD+D DFIG LS+ Q
Sbjct: 523 FHLYE------ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQ 563
Score = 30.0 bits (66), Expect = 5.8
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 11/79 (13%)
Query: 159 LDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQPFSIPVRALCNGDYDR- 217
L +D G SDP++ F ++ +++++ LNPVW+ +A D+ R
Sbjct: 273 LAARDRGGTSDPYVKFKIGGKE-----VFRSKIIHKNLNPVWEE-----KACILVDHLRE 322
Query: 218 TVKIDVYDWDRDGSHDFIG 236
+ I V+D+D DF+G
Sbjct: 323 PLYIKVFDYDFGLQDDFMG 341
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 7/118 (5%)
Query: 131 KKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTE 190
+K G I L AE + A L D G SDP+ V + D KT+
Sbjct: 157 EKRGRIYLKAEVADEKLHVTVRD--AKNLIPMDPNGLSDPY-VKLKLIPDPKNESKQKTK 213
Query: 191 VVKNTLNPVW-QPFSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRELSK 247
+++TLNP W + F+ ++ D DR + ++++DWDR +DF+G + EL K
Sbjct: 214 TIRSTLNPQWNESFTFKLKP---SDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMK 268
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/126 (32%), Positives = 54/126 (42%), Gaps = 15/126 (11%)
Query: 115 GGQGSRVERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVF 174
GG GS T G CG I L + L A L KD G SDP++
Sbjct: 287 GGPGSGEAGT-----GAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKI 341
Query: 175 YRSNEDGTFTICHKTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGS 231
Y + +T+V + TLNPV+ FS+P+ L R + VYD+DR
Sbjct: 342 YLLPDRKKK---FQTKVHRKTLNPVFNETFQFSVPLAELAQ----RKLHFSVYDFDRFSR 394
Query: 232 HDFIGE 237
HD IG+
Sbjct: 395 HDLIGQ 400
Score = 40.0 bits (92), Expect = 0.006
Identities = 67/273 (24%), Positives = 104/273 (38%), Gaps = 26/273 (9%)
Query: 17 EITVSCRNLLDL---DTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
++ V LDL D+ SDP V +Y ++++ T+V TLNP F F
Sbjct: 315 QLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQ----TKVHRKTLNPVFNETFQF 370
Query: 74 DYFFEE--KQNLRFDVYNVDSKTNISKPKDFLGQA----FLALGEVIGGQGSRVERTLTG 127
E ++ L F VY+ D + D +GQ L L E + + G
Sbjct: 371 SVPLAELAQRKLHFSVYDFDRFSR----HDLIGQVVLDNLLELAEQPPDRPLWRDIVEGG 426
Query: 128 VPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICH 187
G + + L + + A+ L D G SDP++ +E G
Sbjct: 427 SEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISE-GRRLKKR 485
Query: 188 KTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRE 244
KT + KNTLNP + F + ++ N + I V D+D G ++ IG
Sbjct: 486 KTSIKKNTLNPTYNEALVFDVAPESVENVG----LSIAVVDYDCIGHNEVIGVCRVGPDA 541
Query: 245 LSKAQNQFTVYEVLNPRKKCKK-KKYVNSGTVT 276
+ + NPRK + + V TVT
Sbjct: 542 ADPHGREHWAEMLANPRKPVEHWHQLVEEKTVT 574
Score = 29.3 bits (64), Expect = 9.8
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 7/82 (8%)
Query: 13 ATKIEITV-SCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGR--TEVIDNTLNPDFVR 69
A ++ +T+ NL +D SDP Y ++ E R + T + NTLNP +
Sbjct: 445 AGRLTVTIIKASNLKAMDLTGFSDP----YVKASLISEGRRLKKRKTSIKKNTLNPTYNE 500
Query: 70 KFVLDYFFEEKQNLRFDVYNVD 91
V D E +N+ + VD
Sbjct: 501 ALVFDVAPESVENVGLSIAVVD 522
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/126 (32%), Positives = 54/126 (42%), Gaps = 15/126 (11%)
Query: 115 GGQGSRVERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVF 174
GG GS T G CG I L + L A L KD G SDP++
Sbjct: 287 GGPGSGEAGT-----GAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKI 341
Query: 175 YRSNEDGTFTICHKTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGS 231
Y + +T+V + TLNPV+ FS+P+ L R + VYD+DR
Sbjct: 342 YLLPDRKKK---FQTKVHRKTLNPVFNETFQFSVPLAELAQ----RKLHFSVYDFDRFSR 394
Query: 232 HDFIGE 237
HD IG+
Sbjct: 395 HDLIGQ 400
Score = 40.0 bits (92), Expect = 0.006
Identities = 67/273 (24%), Positives = 104/273 (38%), Gaps = 26/273 (9%)
Query: 17 EITVSCRNLLDL---DTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
++ V LDL D+ SDP V +Y ++++ T+V TLNP F F
Sbjct: 315 QLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQ----TKVHRKTLNPVFNETFQF 370
Query: 74 DYFFEE--KQNLRFDVYNVDSKTNISKPKDFLGQA----FLALGEVIGGQGSRVERTLTG 127
E ++ L F VY+ D + D +GQ L L E + + G
Sbjct: 371 SVPLAELAQRKLHFSVYDFDRFSR----HDLIGQVVLDNLLELAEQPPDRPLWRDIVEGG 426
Query: 128 VPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICH 187
G + + L + + A+ L D G SDP++ +E G
Sbjct: 427 SEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISE-GRRLKKR 485
Query: 188 KTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRE 244
KT + KNTLNP + F + ++ N + I V D+D G ++ IG
Sbjct: 486 KTSIKKNTLNPTYNEALVFDVAPESVENVG----LSIAVVDYDCIGHNEVIGVCRVGPDA 541
Query: 245 LSKAQNQFTVYEVLNPRKKCKK-KKYVNSGTVT 276
+ + NPRK + + V TVT
Sbjct: 542 ADPHGREHWAEMLANPRKPVEHWHQLVEEKTVT 574
Score = 29.3 bits (64), Expect = 9.8
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 7/82 (8%)
Query: 13 ATKIEITV-SCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGR--TEVIDNTLNPDFVR 69
A ++ +T+ NL +D SDP Y ++ E R + T + NTLNP +
Sbjct: 445 AGRLTVTIIKASNLKAMDLTGFSDP----YVKASLISEGRRLKKRKTSIKKNTLNPTYNE 500
Query: 70 KFVLDYFFEEKQNLRFDVYNVD 91
V D E +N+ + VD
Sbjct: 501 ALVFDVAPESVENVGLSIAVVD 522
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/126 (32%), Positives = 54/126 (42%), Gaps = 15/126 (11%)
Query: 115 GGQGSRVERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVF 174
GG GS T G CG I L + L A L KD G SDP++
Sbjct: 287 GGPGSGEAGT-----GAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKI 341
Query: 175 YRSNEDGTFTICHKTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGS 231
Y + +T+V + TLNPV+ FS+P+ L R + VYD+DR
Sbjct: 342 YLLPDRKKK---FQTKVHRKTLNPVFNETFQFSVPLAELAQ----RKLHFSVYDFDRFSR 394
Query: 232 HDFIGE 237
HD IG+
Sbjct: 395 HDLIGQ 400
Score = 40.0 bits (92), Expect = 0.006
Identities = 67/273 (24%), Positives = 104/273 (38%), Gaps = 26/273 (9%)
Query: 17 EITVSCRNLLDL---DTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVL 73
++ V LDL D+ SDP V +Y ++++ T+V TLNP F F
Sbjct: 315 QLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQ----TKVHRKTLNPVFNETFQF 370
Query: 74 DYFFEE--KQNLRFDVYNVDSKTNISKPKDFLGQA----FLALGEVIGGQGSRVERTLTG 127
E ++ L F VY+ D + D +GQ L L E + + G
Sbjct: 371 SVPLAELAQRKLHFSVYDFDRFSR----HDLIGQVVLDNLLELAEQPPDRPLWRDIVEGG 426
Query: 128 VPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICH 187
G + + L + + A+ L D G SDP++ +E G
Sbjct: 427 SEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISE-GRRLKKR 485
Query: 188 KTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIGEFTTSYRE 244
KT + KNTLNP + F + ++ N + I V D+D G ++ IG
Sbjct: 486 KTSIKKNTLNPTYNEALVFDVAPESVENVG----LSIAVVDYDCIGHNEVIGVCRVGPDA 541
Query: 245 LSKAQNQFTVYEVLNPRKKCKK-KKYVNSGTVT 276
+ + NPRK + + V TVT
Sbjct: 542 ADPHGREHWAEMLANPRKPVEHWHQLVEEKTVT 574
Score = 29.3 bits (64), Expect = 9.8
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 7/82 (8%)
Query: 13 ATKIEITV-SCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGR--TEVIDNTLNPDFVR 69
A ++ +T+ NL +D SDP Y ++ E R + T + NTLNP +
Sbjct: 445 AGRLTVTIIKASNLKAMDLTGFSDP----YVKASLISEGRRLKKRKTSIKKNTLNPTYNE 500
Query: 70 KFVLDYFFEEKQNLRFDVYNVD 91
V D E +N+ + VD
Sbjct: 501 ALVFDVAPESVENVGLSIAVVD 522
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 48.1 bits (113), Expect = 2e-05
Identities = 38/127 (29%), Positives = 55/127 (43%), Gaps = 16/127 (12%)
Query: 114 IGGQGSRVERTLTGVPGKKCGTILLTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLV 173
+ G+ ++ E T K CG I + + L A L KDF G SDP++
Sbjct: 132 VDGEDAKSEAT------KSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVK 185
Query: 174 FYRSNEDGTFTICHKTEVVKNTLNPVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDG 230
Y + +T V + TLNP + F +P L DR + + V+D+DR
Sbjct: 186 IYLLPDRKCKL---QTRVHRKTLNPTFDENFHFPVPYEELA----DRKLHLSVFDFDRFS 238
Query: 231 SHDFIGE 237
HD IGE
Sbjct: 239 RHDMIGE 245
Score = 37.7 bits (86), Expect = 0.028
Identities = 58/217 (26%), Positives = 86/217 (39%), Gaps = 22/217 (10%)
Query: 29 DTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRKFVLDYFFEE--KQNLRFD 86
D SDP V +Y + + T V TLNP F F +EE + L
Sbjct: 175 DFCGSSDPYVKIYLLPDRKCKLQ----TRVHRKTLNPTFDENFHFPVPYEELADRKLHLS 230
Query: 87 VYNVDSKTNISKPKDFLGQAFLA-LGEVIG-GQGSRVERTLTGVPGKKC--GTILLTAEE 142
V++ D + D +G+ L L E + + + + + + G I+ +
Sbjct: 231 VFDFDRFSR----HDMIGEVILDNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSLCY 286
Query: 143 LSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVWQP 202
L + + L D G SDP+ V DG KT + KNTLNPV+
Sbjct: 287 LPTAGRLTLTVIKCRNLKAMDITGYSDPY-VKVSLLCDGRRLKKKKTTIKKNTLNPVYNE 345
Query: 203 ---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIG 236
F IP N D ++ I V D+DR G ++ IG
Sbjct: 346 AIIFDIPPE---NMD-QVSLLISVMDYDRVGHNEIIG 378
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 156 ANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLNPVW-QPFSIPVRALCNGD 214
A L KDF G SDP++ Y + T H+T+V + TLNPV+ + F PV N
Sbjct: 244 AVNLPAKDFSGTSDPYVKIYLLPDRKTK---HQTKVHRKTLNPVFDEVFLFPVPY--NDL 298
Query: 215 YDRTVKIDVYDWDRDGSHDFIGEFTTSY 242
R + VYD+DR HD IG+ +
Sbjct: 299 EARKLHFSVYDFDRFSRHDLIGQVVVDH 326
Score = 41.2 bits (95), Expect = 0.003
Identities = 62/222 (27%), Positives = 86/222 (38%), Gaps = 22/222 (9%)
Query: 24 NLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDF--VRKFVLDYFFEEKQ 81
NL D SDP V +Y + + T+V TLNP F V F + Y E +
Sbjct: 246 NLPAKDFSGTSDPYVKIYLLPDRKTKHQ----TKVHRKTLNPVFDEVFLFPVPYNDLEAR 301
Query: 82 NLRFDVYNVDSKTNISKPKDFLGQA----FLALGEVIGGQGSRVERTLTGVPGKKCGTIL 137
L F VY+ D + D +GQ FL L + + G ++
Sbjct: 302 KLHFSVYDFDRFSR----HDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGELM 357
Query: 138 LTAEELSNCRDIATMQLCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVVKNTLN 197
+ L + + A L D G SDP+ V DG KT +NTLN
Sbjct: 358 FSLCYLPTAGRLTITIIKARNLKAMDITGASDPY-VKVSLMCDGRRLKKRKTSTKRNTLN 416
Query: 198 PVWQP---FSIPVRALCNGDYDRTVKIDVYDWDRDGSHDFIG 236
PV+ F +P N D + I V D+DR G ++ IG
Sbjct: 417 PVYNEAIVFDVPPE---NIDQIH-LSIAVMDYDRVGHNEIIG 454
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,214,374
Number of Sequences: 37866
Number of extensions: 966933
Number of successful extensions: 7565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 6839
Number of HSP's gapped (non-prelim): 577
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.