BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|8393378 frizzled 3 [Homo sapiens] (666 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|8393378 frizzled 3 [Homo sapiens] 1381 0.0 gi|34734079 frizzled 6 [Homo sapiens] 684 0.0 gi|4503833 frizzled 7 [Homo sapiens] 484 e-136 gi|4503825 frizzled 1 [Homo sapiens] 482 e-136 gi|4503827 frizzled 2 [Homo sapiens] 475 e-134 gi|6005762 frizzled 10 [Homo sapiens] 374 e-103 gi|27894385 frizzled 5 precursor [Homo sapiens] 366 e-101 gi|4503835 frizzled 9 [Homo sapiens] 352 6e-97 gi|22547161 frizzled 4 [Homo sapiens] 323 2e-88 gi|13994190 frizzled 8 [Homo sapiens] 272 8e-73 gi|5032099 smoothened [Homo sapiens] 167 3e-41 gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] 103 7e-22 gi|38455388 frizzled-related protein [Homo sapiens] 95 2e-19 gi|29244926 corin [Homo sapiens] 91 3e-18 gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] 87 6e-17 gi|48475052 secreted frizzled-related protein 2 precursor [Homo ... 87 6e-17 gi|13899255 membrane frizzled-related protein [Homo sapiens] 84 5e-16 gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] 83 7e-16 gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] 68 2e-11 gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] 68 2e-11 gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 49 1e-05 gi|45433552 G protein-coupled receptor 133 [Homo sapiens] 49 2e-05 gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 48 3e-05 gi|59710093 G-protein coupled receptor 112 [Homo sapiens] 47 6e-05 gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Ho... 42 0.001 gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom... 42 0.001 gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Ho... 42 0.001 gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom... 42 0.001 gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 42 0.002 gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] 42 0.002 >gi|8393378 frizzled 3 [Homo sapiens] Length = 666 Score = 1381 bits (3574), Expect = 0.0 Identities = 666/666 (100%), Positives = 666/666 (100%) Query: 1 MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL 60 MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL Sbjct: 1 MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL 60 Query: 61 AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP 120 AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP Sbjct: 61 AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP 120 Query: 121 WPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL 180 WPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL Sbjct: 121 WPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL 180 Query: 181 HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF 240 HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF Sbjct: 181 HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF 240 Query: 241 YAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAG 300 YAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAG Sbjct: 241 YAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAG 300 Query: 301 SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV 360 SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV Sbjct: 301 SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV 360 Query: 361 CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR 420 CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR Sbjct: 361 CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR 420 Query: 421 IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF 480 IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF Sbjct: 421 IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF 480 Query: 481 LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP 540 LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP Sbjct: 481 LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP 540 Query: 541 NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPC 600 NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPC Sbjct: 541 NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPC 600 Query: 601 SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE 660 SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE Sbjct: 601 SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE 660 Query: 661 EDGTSA 666 EDGTSA Sbjct: 661 EDGTSA 666 >gi|34734079 frizzled 6 [Homo sapiens] Length = 706 Score = 684 bits (1766), Expect = 0.0 Identities = 344/633 (54%), Positives = 419/633 (66%), Gaps = 27/633 (4%) Query: 7 VFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFH 66 +F+ +F+ + GHSLF+CEPIT+ C + YN TF PNL+ HYDQ AA+ ME F Sbjct: 3 MFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL 62 Query: 67 PMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDME 126 P+ NL+CS + FLC + P C+E V PCR+LC++ YS+C KL++ FG+ WPE++E Sbjct: 63 PLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELE 122 Query: 127 CSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCS 186 C R CDE P D + + VQRD GFWCPR LK GY FL + C+ Sbjct: 123 CDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCA 182 Query: 187 PPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYM 246 PPCPNMYF+ +EL FA+ FIG +SI CL ATLFTFLTFLIDV RFRYPERPII+Y+VCY Sbjct: 183 PPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYS 242 Query: 247 MVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVI 306 +VSL++FIGFLL D ACN + TV GS NKACT+LFM+LYFFTMAG+VWWVI Sbjct: 243 IVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVI 302 Query: 307 LTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLY 366 LTITWFLAA KW EAIE+KA+ FHA AWG PG LT++LLAMNK+EGDNISGVCFVGLY Sbjct: 303 LTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLY 362 Query: 367 DVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSI 426 D+DA RYFVL PLCL V VG+SLLLAGIISLN VR I + NQ+KL KFMIRIGVFS Sbjct: 363 DLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVFSG 422 Query: 427 LYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLM 486 LYLVPL+ ++GCY YEQ R WE TW+ + CR+YHIPCPYQ +RP+L LF++KYLM Sbjct: 423 LYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKYLM 482 Query: 487 ALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLR-------- 538 LIVGI +VFWVGSKKTC EWA FF RK++ ++ESR+VLQE + L+ Sbjct: 483 TLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQES--CEFFLKHNSKVKHK 540 Query: 539 -------DPNTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHR 591 +I KS GTST T+ H +S D + + S Sbjct: 541 KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV 600 Query: 592 SRDGRYTP------CSYRGMEERLPHGSMSRLT 618 DG TP C E P S+SRL+ Sbjct: 601 KADGASTPRLREQDCG----EPASPAASISRLS 629 >gi|4503833 frizzled 7 [Homo sapiens] Length = 574 Score = 484 bits (1246), Expect = e-136 Identities = 237/516 (45%), Positives = 316/516 (61%), Gaps = 33/516 (6%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 C+PI++ +C D+ YN T +PNLL H +Q+ A L + F+P+V + CS + R FLC++YAP Sbjct: 49 CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108 Query: 88 ICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP---------------- 131 +C + PCR LC+RA C LM FG WPE + C FP Sbjct: 109 VCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDG 168 Query: 132 --------DCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVR 183 P L DL P + + + F CPR+LK+ P LGY FL R Sbjct: 169 SGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGER 228 Query: 184 DCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERP 237 DC PC MYF+ EE FAR ++G+ S++C ++TLFT LT+L+D+ RF YPERP Sbjct: 229 DCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERP 288 Query: 238 IIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQ-YKASTVTQGSHNKACTMLFMILYFF 296 IIF + CY MV++ GFLLEDR C Y+ TV QG+ + CT+LFM+LYFF Sbjct: 289 IIFLSGCYFMVAVAHVAGFLLEDRAVCVERFSDDGYR--TVAQGTKKEGCTILFMVLYFF 346 Query: 297 TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDN 356 MA S+WWVIL++TWFLAA KWG EAIE + FH +AW +P TI +LAM +++GD Sbjct: 347 GMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDL 406 Query: 357 ISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVK 416 +SGVC+VGL VDALR FVLAPL +Y+ +G S LLAG +SL R+R + + +KL K Sbjct: 407 LSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEK 466 Query: 417 FMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPD 476 M+RIGVFS+LY VP +V+ CYFYEQA+R WE TW+ + C+ Y +PCP PD Sbjct: 467 LMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPD 526 Query: 477 LILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFH 512 +F++KYLM +IVGI + FW+ S KT W F+H Sbjct: 527 FTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYH 562 >gi|4503825 frizzled 1 [Homo sapiens] Length = 647 Score = 482 bits (1240), Expect = e-136 Identities = 239/520 (45%), Positives = 319/520 (61%), Gaps = 37/520 (7%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 C+PI++ +C D+ YN T MPNLL H +Q+ A L + F+P+V + CS + + FLC++YAP Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175 Query: 88 ICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP--------------DC 133 +C + PCR LC+RA C LM FG WP+ ++C +FP D Sbjct: 176 VCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDK 235 Query: 134 DEPYPRLVDLNLAGEPTEGAP---------VAVQRDYGFWCPRELKIDPDLGYSFLHVRD 184 P P L+ P G F CPR LK+ L Y FL +D Sbjct: 236 GTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKD 295 Query: 185 CSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPI 238 C PC MYF EEL F+R +IG+ S++C ++TLFT LT+L+D+ RF YPERPI Sbjct: 296 CGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPI 355 Query: 239 IFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTM 298 IF + CY V++ + GFLLEDRV CN A+ A TV QG+ + CT+LFM+LYFF+M Sbjct: 356 IFLSGCYTAVAVAYIAGFLLEDRVVCNDKF-AEDGARTVAQGTKKEGCTILFMMLYFFSM 414 Query: 299 AGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNIS 358 A S+WWVIL++TWFLAA KWG EAIE + FH +AW +P TI +LA+ +++GD +S Sbjct: 415 ASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLS 474 Query: 359 GVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFM 418 GVCFVGL +VDALR FVLAPL +Y+ +G S LLAG +SL R+R + + +KL K M Sbjct: 475 GVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLM 534 Query: 419 IRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVT-------Q 471 +RIGVFS+LY VP +VI CYFYEQA+R WE +W+ + C+ Y IPCP+ Sbjct: 535 VRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHP 594 Query: 472 MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFF 511 PD +F++KYLM LIVGI S FW+ S KT W F+ Sbjct: 595 PMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFY 634 >gi|4503827 frizzled 2 [Homo sapiens] Length = 565 Score = 475 bits (1223), Expect = e-134 Identities = 233/515 (45%), Positives = 317/515 (61%), Gaps = 32/515 (6%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 C+PI++ +C D+ YN T MPNLL H +Q+ A L + F+P+V + CS + R FLC++YAP Sbjct: 39 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98 Query: 88 ICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP------------DCDE 135 +C + PCR +C+RA C LM FG WPE + C FP ++ Sbjct: 99 VCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSED 158 Query: 136 PYPRLVDL-----------NLAGEPTEGA--PVAVQRDYGFWCPRELKIDPDLGYSFLHV 182 P L+ G P G P ++ F CPR LK+ L Y FL Sbjct: 159 GAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGE 218 Query: 183 RDCSPPCP------NMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPER 236 RDC+ PC +M+F +EE FAR +I S++C ++T FT T+L+D+ RFRYPER Sbjct: 219 RDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPER 278 Query: 237 PIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFF 296 PIIF + CY MVS+ + GF+L++RV CN ++ TV QG+ + CT+LFM+LYFF Sbjct: 279 PIIFLSGCYTMVSVAYIAGFVLQERVVCNERF-SEDGYRTVVQGTKKEGCTILFMMLYFF 337 Query: 297 TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDN 356 +MA S+WWVIL++TWFLAA KWG EAIE + FH +AW +P TI +LAM +I+GD Sbjct: 338 SMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDL 397 Query: 357 ISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVK 416 +SGVCFVGL +D LR FVLAPL +Y+ +G S LLAG +SL R+R + + +KL + Sbjct: 398 LSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLER 457 Query: 417 FMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPD 476 M+RIGVFS+LY VP +VI CYFYEQA+R WE +W+ + C+ IPCP T PD Sbjct: 458 LMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPD 517 Query: 477 LILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFF 511 ++++KYLM LIVGI S FW+ S KT W F+ Sbjct: 518 FTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFY 552 >gi|6005762 frizzled 10 [Homo sapiens] Length = 581 Score = 374 bits (961), Expect = e-103 Identities = 200/515 (38%), Positives = 299/515 (58%), Gaps = 30/515 (5%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 C+PI + MC+D+ YN T MPNL+ H +Q+ AA+ + F P+V C R FLC+LYAP Sbjct: 34 CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93 Query: 88 ICMEYGRVTLP-CRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDL--N 144 +C E +P CR +C++A +CS +ME F WP+ ++C + P+ ++P ++ N Sbjct: 94 MCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNN 153 Query: 145 LAGEPTEGAPV-----AVQRDYGFWCPRELKIDPDLGY-----SFLHVR---DCSPPCP- 190 + EPT G+ + QR + P G F HV C+P C Sbjct: 154 GSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTP 213 Query: 191 --NMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMV 248 ++Y+ RE+ FA ++ + +++C ++ FT LTFLID RFRYPERPIIF ++CY + Sbjct: 214 GVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVY 273 Query: 249 SLIFFIG-FLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVIL 307 S+ + I F + +AC+ Y + +G + CT++F++LY+F MA S+WWV+L Sbjct: 274 SVGYLIRLFAGAESIACDRDSGQLY---VIQEGLESTGCTLVFLVLYYFGMASSLWWVVL 330 Query: 308 TITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYD 367 T+TWFLAA KWG EAIE + FH +AW IP TI++L M ++ GD ++GVC+VG D Sbjct: 331 TLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMD 390 Query: 368 VDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSIL 427 V+AL FVL PL Y+V+G S +L+G ++L +R + EN DKL K M+RIG+FS+L Sbjct: 391 VNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVL 450 Query: 428 YLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYH----IPCPYQVTQMSRPDLILFLMK 483 Y VP VI CYFYE+ W+ Q +C+ + + C + S P + +F++K Sbjct: 451 YTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDC---LMAASIPAVEIFMVK 507 Query: 484 YLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE 518 M L+VGI S W+ + KT W R KK+ Sbjct: 508 IFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKK 542 >gi|27894385 frizzled 5 precursor [Homo sapiens] Length = 585 Score = 366 bits (939), Expect = e-101 Identities = 211/516 (40%), Positives = 286/516 (55%), Gaps = 48/516 (9%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 C+ IT+ MC+ + YN T MPN NH Q A L + F P+V + CS D R FLC++Y P Sbjct: 33 CQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTP 92 Query: 88 ICM-EYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP----DCD-------- 134 IC+ +Y + PCR +C+RA + CS LM +G WPE M C R P D + Sbjct: 93 ICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNR 152 Query: 135 ------EPYPRLVDLNLAGEPTEGAPVA---VQRDYGFWCPRELKIDPDLGYSFL----- 180 P P L G P GAP + F C P L S Sbjct: 153 SEATTAPPRPFPAKPTLPGPP--GAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKV 210 Query: 181 ---HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERP 237 V +C+ PC F +E +FA ++IGL S++C +T T TFLID+ RFRYPERP Sbjct: 211 RTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERP 270 Query: 238 IIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKA-CTMLFMILYFF 296 IIF + CY+ VSL GFL+ V +AS+ + + + + A CT++F+++YFF Sbjct: 271 IIFLSACYLCVSL----GFLVR-LVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFF 325 Query: 297 TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDN 356 MA S+WWVIL++TWFLAA KWG+EAI A FH +AW IP +I LA++ ++GD Sbjct: 326 GMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDP 385 Query: 357 ISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVK 416 ++G+C+VG ++++LR FVL PL LY++VG LLAG +SL R+R I DKL K Sbjct: 386 VAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEK 445 Query: 417 FMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSR-- 474 MIRIG+F++LY VP +V+ CY YEQ YR WE CP T R Sbjct: 446 LMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAA--------LTCACPGHDTGQPRAK 497 Query: 475 PDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASF 510 P+ + ++KY M L+VGI S W+ S KT W F Sbjct: 498 PEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRF 533 >gi|4503835 frizzled 9 [Homo sapiens] Length = 591 Score = 352 bits (903), Expect = 6e-97 Identities = 194/513 (37%), Positives = 280/513 (54%), Gaps = 31/513 (6%) Query: 22 GHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFL 81 G C+ + + MC+ + YN T MPNLL H Q AA + F P+V C R FL Sbjct: 33 GRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFL 92 Query: 82 CALYAPICMEYGRVTLP-CRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRL 140 C+LYAP+C + +P CR +C++A C+ +ME F WP+ ++C+R P ++P+ Sbjct: 93 CSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALC 152 Query: 141 VDLNLAGEPTEGAPVAVQRDYGFW--CPRELKIDPDLG------------YSFLHV---R 183 ++ A E P + G PR + DLG F +V R Sbjct: 153 ME---APENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSR 209 Query: 184 DCSPPCP---NMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF 240 C+P C +++ R + FA ++ + S +C +T FT LTFL++ RF+YPERPIIF Sbjct: 210 SCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIF 269 Query: 241 YAVCYMMVSLIFFIGFLL-EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMA 299 ++CY + SL F I + VAC+ A Y + +G N CT++F++LY+F MA Sbjct: 270 LSMCYNVYSLAFLIRAVAGAQSVACDQEAGALY---VIQEGLENTGCTLVFLLLYYFGMA 326 Query: 300 GSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISG 359 S+WWV+LT+TWFLAA KWG EAIE FH +AWG+P TI++L + K+ GD ++G Sbjct: 327 SSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTG 386 Query: 360 VCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMI 419 +C+V D AL FVL PL Y+V+G S LL G ++L +R + N +KL K M+ Sbjct: 387 LCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMV 446 Query: 420 RIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQM---SRPD 476 +IGVFSILY VP VI CY YE+ W ++ C P + + S P Sbjct: 447 KIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPT 506 Query: 477 LILFLMKYLMALIVGIPSVFWVGSKKTCFEWAS 509 + +F++K M+L+VGI S WV S KT W S Sbjct: 507 VAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQS 539 >gi|22547161 frizzled 4 [Homo sapiens] Length = 537 Score = 323 bits (829), Expect = 2e-88 Identities = 177/496 (35%), Positives = 264/496 (53%), Gaps = 52/496 (10%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 C+PI + MCQ+L YN T MPNL+ H Q A L + F P++ CS + FLC++Y P Sbjct: 45 CDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVP 104 Query: 88 ICMEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP--------------D 132 +C E + + PC +C C +++ FG WPE + CS+FP D Sbjct: 105 MCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGD 164 Query: 133 CDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNM 192 + P P + GE E V D W R L GY + Sbjct: 165 EEVPLPHKTPIQ-PGE--ECHSVGTNSDQYIWVKRSLNCVLKCGYD-----------AGL 210 Query: 193 YFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIF 252 Y R + F ++ + + +C +T FT LTFLID +RF YPERPIIF ++CY + S+ + Sbjct: 211 YSRSAK-EFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAY 269 Query: 253 FIGFLL-EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITW 311 + + +R++C+ A+ + +G N C ++F+++YFF MA S+WWVILT+TW Sbjct: 270 IVRLTVGRERISCDFEEAAE--PVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTW 327 Query: 312 FLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDAL 371 FLAA KWG EAIE + FH +AW IP TI++L M ++ D ++G+C+VG ++DAL Sbjct: 328 FLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDAL 387 Query: 372 RYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVP 431 FV+APL Y+V+G + AG+++L ++R + + DKL + M++IGVFS+LY VP Sbjct: 388 TGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVP 447 Query: 432 LLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILFLMKYLMALIVG 491 VI CYFYE + W R ++ + ++K M+L+VG Sbjct: 448 ATCVIACYFYE-------ISNWALFR------------YSADDSNMAVEMLKIFMSLLVG 488 Query: 492 IPSVFWVGSKKTCFEW 507 I S W+ S KT W Sbjct: 489 ITSGMWIWSAKTLHTW 504 >gi|13994190 frizzled 8 [Homo sapiens] Length = 694 Score = 272 bits (695), Expect = 8e-73 Identities = 146/367 (39%), Positives = 210/367 (57%), Gaps = 47/367 (12%) Query: 182 VRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFY 241 + +C+ PC N +F ++E +F ++IGL S++C +T T TFLID+ RF+YPERPIIF Sbjct: 257 IANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFL 316 Query: 242 AVCYMMVSLIFFIGFLL-EDRVACNASIP----------AQYKASTVTQGSHNKA----- 285 + CY+ VS+ + + + ++VAC+ P A A G+ Sbjct: 317 SACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEY 376 Query: 286 -------------------CTMLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEK 326 CT++F+++YFF MA S+WWVIL++TWFLAA KWG+EAI Sbjct: 377 EELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAG 436 Query: 327 KALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVG 386 + FH +AW +P +I +LA++ ++GD ++G+C+VG +D LR FVLAPL +Y+ +G Sbjct: 437 YSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIG 496 Query: 387 VSLLLAGIISLNRVRIEIPLE--KENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQA 444 LLAG +SL R+R I + KL K MIR+G+F++LY VP VV+ C FYEQ Sbjct: 497 TMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQH 556 Query: 445 YRGIWETTWIQERCREYHIPC--PYQVTQMSRPDLILFLMKYLMALIVGIPSVFWVGSKK 502 R WE T ++ PC Q Q RPD +F++KY M L+VGI S WV S K Sbjct: 557 NRPRWEAT--------HNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGK 608 Query: 503 TCFEWAS 509 T W S Sbjct: 609 TLESWRS 615 Score = 113 bits (283), Expect = 5e-25 Identities = 53/134 (39%), Positives = 78/134 (58%), Gaps = 2/134 (1%) Query: 27 SCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYA 86 +C+ IT+ +C+ + YN T+MPN NH Q A L + F P+V + CS D + FLC++Y Sbjct: 34 ACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYT 93 Query: 87 PICME-YGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDLNL 145 PIC+E Y + PCR +C+RA + C+ LM +G WP+ M C R P+ P +D N Sbjct: 94 PICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNR 153 Query: 146 AGEPTEGAPVAVQR 159 + T AP +R Sbjct: 154 T-DLTTAAPSPPRR 166 >gi|5032099 smoothened [Homo sapiens] Length = 787 Score = 167 bits (423), Expect = 3e-41 Identities = 134/504 (26%), Positives = 222/504 (44%), Gaps = 52/504 (10%) Query: 28 CEPITLRMCQD--LPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLD-CSRDFRPFLCAL 84 CEP+ +C LPY T + Q+ A + + + N C +P LCA+ Sbjct: 70 CEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAV 129 Query: 85 YAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECS--RFPDCDEPYPRLVD 142 Y P C E RV LP R LCQ C+ + G WP+ + C+ RFP+ + + Sbjct: 130 YMPKC-ENDRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDRFPEGCTNEVQNIK 186 Query: 143 LNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFLHVRDCSPPCPNMYFRREELSFA 202 N +G+ P+ + W + V C C N F E Sbjct: 187 FNSSGQCE--VPLVRTDNPKSW--------------YEDVEGCGIQCQNPLFTEAEHQDM 230 Query: 203 RYFIGLISIICLSATLFTFLTFLIDVTRF-RYPERPIIFYAVCYMMVSLIFFIGFLLEDR 261 +I + TLFT TF+ D RYP + + C+ + S+ + F+ R Sbjct: 231 HSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGAR 290 Query: 262 --VACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKW 319 + C A + T + +C ++F+I+Y+ MAG VW+V+LT W + Sbjct: 291 REIVCRADGTMRLGEPT---SNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALG 347 Query: 320 GS-EAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAP 378 + + + K FH W +P LT+ +LA+ +++GD++SG+CFVG + FVLAP Sbjct: 348 TTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAP 407 Query: 379 LCLYVVVGVSLLLAGIISLNRVRIEIP--LEKENQDKLVKFMIRIGVFSILYLVPLLVVI 436 + L ++VG L+ G+++L ++ P L ++ K+ + M+R+G+F L +L+ Sbjct: 408 IGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITF 467 Query: 437 GCYFYEQAYRGIWETTWIQERCREYHIPCPYQVT-------------QMSRPDLILFLMK 483 C+FY+ + WE ++ R+Y + C VT +RP L++ + Sbjct: 468 SCHFYDFFNQAEWERSF-----RDY-VLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKIN 521 Query: 484 YLMALIVGIPSVFWVGSKKTCFEW 507 GI WV +K T W Sbjct: 522 LFAMFGTGIAMSTWVWTKATLLIW 545 >gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] Length = 346 Score = 103 bits (256), Expect = 7e-22 Identities = 47/109 (43%), Positives = 70/109 (64%), Gaps = 2/109 (1%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87 CE + + MC+ +P+N T MPN L+H Q+ A LA+E + +V+++CS R FLCA+YAP Sbjct: 24 CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83 Query: 88 IC-MEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 134 IC +E+ + PC+ +CQRA +C LM+M+ WPE + C P D Sbjct: 84 ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYD 132 >gi|38455388 frizzled-related protein [Homo sapiens] Length = 325 Score = 94.7 bits (234), Expect = 2e-19 Identities = 44/117 (37%), Positives = 68/117 (58%), Gaps = 2/117 (1%) Query: 20 IGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRP 79 + G +CEP+ + +C+ LP+N T MPN L+H Q A LA+E F ++ CS D Sbjct: 27 VPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLF 86 Query: 80 FLCALYAPIC-MEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 134 FLCA+YAPIC +++ + PC+ +C+RA C ++ + WPE++ C P D Sbjct: 87 FLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYD 143 >gi|29244926 corin [Homo sapiens] Length = 1042 Score = 91.3 bits (225), Expect = 3e-18 Identities = 41/108 (37%), Positives = 62/108 (57%), Gaps = 3/108 (2%) Query: 28 CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLDCSRDFRPFLCALY 85 CEPITL +C +LPYN+T PN H Q+ A+++ E F +V +C + F C + Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514 Query: 86 APIC-MEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPD 132 P C + G PCR LC+ + C ++ + G+ WPED +CS+FP+ Sbjct: 515 VPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPE 562 Score = 56.2 bits (134), Expect = 9e-08 Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 4/107 (3%) Query: 27 SCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYA 86 +C IT CQ LPY+ T P LL+ ++ F + L C + F C L Sbjct: 138 ACMNITHSQCQMLPYHATLTP-LLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAF 196 Query: 87 PICMEYGRVT---LPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRF 130 P C+ G + LPCR C+ A C ++ M WP+ + CS+F Sbjct: 197 PECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQF 243 >gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] Length = 314 Score = 86.7 bits (213), Expect = 6e-17 Identities = 37/105 (35%), Positives = 58/105 (55%), Gaps = 2/105 (1%) Query: 30 PITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC 89 P LR+C ++ Y +PNLL H + P++N +C + FLC+L+AP+C Sbjct: 62 PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121 Query: 90 MEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 134 ++ R PCR LC+ C +M+ FG WPE ++C +FP+ D Sbjct: 122 LD--RPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGD 164 >gi|48475052 secreted frizzled-related protein 2 precursor [Homo sapiens] Length = 295 Score = 86.7 bits (213), Expect = 6e-17 Identities = 44/131 (33%), Positives = 68/131 (51%), Gaps = 3/131 (2%) Query: 27 SCEPI--TLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCAL 84 +C+PI L++C + Y +PNLL H + + P+V C D + FLC+L Sbjct: 39 NCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSL 98 Query: 85 YAPICMEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDL 143 +AP+C++ T+ PC LC + C+ +M FG PWP+ +EC RFP ++ L Sbjct: 99 FAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASS 158 Query: 144 NLAGEPTEGAP 154 + TE AP Sbjct: 159 DHLLPATEEAP 169 >gi|13899255 membrane frizzled-related protein [Homo sapiens] Length = 579 Score = 83.6 bits (205), Expect = 5e-16 Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 3/107 (2%) Query: 27 SCEPITLRMCQDLPYNTTFMPNL-LNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALY 85 +CEP+ + MC L YNTT PN+ + Q+ + + + +L C + FR LC L Sbjct: 465 ACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLL 524 Query: 86 APICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPD 132 P C G V PCR +CQ A +C + + G PWP C+R P+ Sbjct: 525 VPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPE 569 >gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] Length = 317 Score = 83.2 bits (204), Expect = 7e-16 Identities = 37/102 (36%), Positives = 55/102 (53%), Gaps = 2/102 (1%) Query: 30 PITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC 89 P L +C + Y +PNLL H + P++ C D + FLC+L+AP+C Sbjct: 57 PADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC 116 Query: 90 MEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP 131 ++ R PCR LC+ + C+ LME +G PWPE + C +FP Sbjct: 117 LD--RPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFP 156 >gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] Length = 641 Score = 68.2 bits (165), Expect = 2e-11 Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 11/124 (8%) Query: 27 SCEPITLRMCQDLPYNTTFMPNLLNH-----YDQQTAALAMEPFHPMVNLDCSRDFRPFL 81 +C + LR C D YN T PNLL H + + + + H ++ C+ D R Sbjct: 31 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 90 Query: 82 CALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRF-----PDCDEP 136 CA+ AP C E G V PCR +C+ C + + WP ++C R+ C +P Sbjct: 91 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149 Query: 137 YPRL 140 +L Sbjct: 150 LEKL 153 >gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] Length = 652 Score = 68.2 bits (165), Expect = 2e-11 Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 11/124 (8%) Query: 27 SCEPITLRMCQDLPYNTTFMPNLLNH-----YDQQTAALAMEPFHPMVNLDCSRDFRPFL 81 +C + LR C D YN T PNLL H + + + + H ++ C+ D R Sbjct: 42 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 101 Query: 82 CALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRF-----PDCDEP 136 CA+ AP C E G V PCR +C+ C + + WP ++C R+ C +P Sbjct: 102 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 160 Query: 137 YPRL 140 +L Sbjct: 161 LEKL 164 >gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo sapiens] Length = 1584 Score = 48.9 bits (115), Expect = 1e-05 Identities = 51/226 (22%), Positives = 91/226 (40%), Gaps = 41/226 (18%) Query: 215 SATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS--LIFFIGFLLEDRVACNASIPAQY 272 S TL + + V R+ ER +I C ++S + IG Sbjct: 959 SLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIG----------------- 1001 Query: 273 KASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITW--FLAAVPKWGSEAIEKKALL 330 TQ + CT++ L+FF ++ W +LT W ++A + I K+ L Sbjct: 1002 ----QTQTRNKVVCTLVAAFLHFFFLSSFCW--VLTEAWQSYMAVTGHLRNRLIRKRFLC 1055 Query: 331 FHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLL 390 WG+P + I + K +G + C++ L L Y + P V+V + Sbjct: 1056 L---GWGLPALVVAISVGFTKAKGYSTMNYCWLSL--EGGLLYAFVGPAAAVVLVN---M 1107 Query: 391 LAGIISLNRVRIEIPLEKEN-QDKLVKFMIRIGVFSILYLVPLLVV 435 + GI+ N++ + K+ DK +K ++S ++PLL + Sbjct: 1108 VIGILVFNKL-----VSKDGITDKKLKERAGASLWSSCVVLPLLAL 1148 >gi|45433552 G protein-coupled receptor 133 [Homo sapiens] Length = 874 Score = 48.5 bits (114), Expect = 2e-05 Identities = 46/196 (23%), Positives = 86/196 (43%), Gaps = 30/196 (15%) Query: 199 LSFARYFIGLISIICLSATLFTF--LTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGF 256 LS Y +S++CL ATL TF L+ + + RY + +AV ++ ++ I F Sbjct: 566 LSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQRYHIHANLSFAV--LVAQVLLLISF 623 Query: 257 LLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAV 316 LE C ++ ++L++F ++ W ++ + + + Sbjct: 624 RLEPGTT---------------------PCQVMAVLLHYFFLSAFAWMLVEGLHLYSMVI 662 Query: 317 PKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVL 376 +GSE + K ++ WG P + II L+ ++ S C++ L A+ FV Sbjct: 663 KVFGSE--DSKHRYYYGMGWGFPLLICIISLSF-AMDSYGTSNNCWLSLAS-GAIWAFV- 717 Query: 377 APLCLYVVVGVSLLLA 392 AP +VV + +L+A Sbjct: 718 APALFVIVVNIGILIA 733 >gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] Length = 1585 Score = 48.1 bits (113), Expect = 3e-05 Identities = 44/195 (22%), Positives = 83/195 (42%), Gaps = 37/195 (18%) Query: 210 SIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVS--LIFFIGFLLEDRVACNAS 267 ++ C++ L T L RF ER II C +++ ++ +G Sbjct: 941 AVSCMA--LLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVG------------ 986 Query: 268 IPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITW--FLAAVPKWGSEAIE 325 ++ +++G CTM L+FF ++ W +LT W +LA + + + + Sbjct: 987 -----QSRVLSKG----VCTMTAAFLHFFFLSSFCW--VLTEAWQSYLAVIGRMRTRLVR 1035 Query: 326 KKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVV 385 K+ F WG+P + + + + +G S C++ L L Y + P + V+V Sbjct: 1036 KR---FLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSL--EGGLLYAFVGPAAVIVLV 1090 Query: 386 GVSLLLAGIISLNRV 400 +L GII N++ Sbjct: 1091 N---MLIGIIVFNKL 1102 >gi|59710093 G-protein coupled receptor 112 [Homo sapiens] Length = 3080 Score = 47.0 bits (110), Expect = 6e-05 Identities = 50/225 (22%), Positives = 95/225 (42%), Gaps = 27/225 (12%) Query: 209 ISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASI 268 IS I L + T++ F R YP + +I +M++L+F I N+ + Sbjct: 2753 ISSIFLGVAVVTYIAF--HKLRKDYPAKILINLCTALLMLNLVFLI----------NSWL 2800 Query: 269 PAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKA 328 + K C + L++F + W + + +LA V K + I Sbjct: 2801 SSFQKVGV---------CITAAVALHYFLLVSFTWMGLEAVHMYLALV-KVFNIYIPNYI 2850 Query: 329 LLFHASAWGIPGTLTIILLAMNK-IEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGV 387 L F WGIP + I +++ K + G F + D V+A CL ++ + Sbjct: 2851 LKFCLVGWGIPAIMVAITVSVKKDLYGTLSPTTPFCWIKDDSIFYISVVAYFCLIFLMNL 2910 Query: 388 SLLLAGIISLNRVRIEIPLEKENQDKLVKFMIRIGVFSILYLVPL 432 S+ ++ LN V+ +I ++ + K++ ++ G S+ +L+ L Sbjct: 2911 SMFCTVLVQLNSVKSQI---QKTRRKMILHDLK-GTMSLTFLLGL 2951 >gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Homo sapiens] Length = 1221 Score = 42.4 bits (98), Expect = 0.001 Identities = 35/150 (23%), Positives = 66/150 (44%), Gaps = 22/150 (14%) Query: 199 LSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLL 258 L+F Y IS I +ATL T++ F + R YP + ++ + + ++L+F + Sbjct: 864 LTFISYIGCGISAIFSAATLLTYVAF--EKLRRDYPSKILMNLSTALLFLNLLFLLD--- 918 Query: 259 EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPK 318 +T + + C + ++L+FF +A W + I ++A V K Sbjct: 919 ----------------GWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALV-K 961 Query: 319 WGSEAIEKKALLFHASAWGIPGTLTIILLA 348 + I + L F WG+P + ++LA Sbjct: 962 VFNTYIRRYILKFCIIGWGLPALVVSVVLA 991 >gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo sapiens] Length = 1250 Score = 42.4 bits (98), Expect = 0.001 Identities = 35/150 (23%), Positives = 66/150 (44%), Gaps = 22/150 (14%) Query: 199 LSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLL 258 L+F Y IS I +ATL T++ F + R YP + ++ + + ++L+F + Sbjct: 864 LTFISYIGCGISAIFSAATLLTYVAF--EKLRRDYPSKILMNLSTALLFLNLLFLLD--- 918 Query: 259 EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPK 318 +T + + C + ++L+FF +A W + I ++A V K Sbjct: 919 ----------------GWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALV-K 961 Query: 319 WGSEAIEKKALLFHASAWGIPGTLTIILLA 348 + I + L F WG+P + ++LA Sbjct: 962 VFNTYIRRYILKFCIIGWGLPALVVSVVLA 991 >gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Homo sapiens] Length = 1193 Score = 42.4 bits (98), Expect = 0.001 Identities = 35/150 (23%), Positives = 66/150 (44%), Gaps = 22/150 (14%) Query: 199 LSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLL 258 L+F Y IS I +ATL T++ F + R YP + ++ + + ++L+F + Sbjct: 836 LTFISYIGCGISAIFSAATLLTYVAF--EKLRRDYPSKILMNLSTALLFLNLLFLLD--- 890 Query: 259 EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPK 318 +T + + C + ++L+FF +A W + I ++A V K Sbjct: 891 ----------------GWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALV-K 933 Query: 319 WGSEAIEKKALLFHASAWGIPGTLTIILLA 348 + I + L F WG+P + ++LA Sbjct: 934 VFNTYIRRYILKFCIIGWGLPALVVSVVLA 963 >gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo sapiens] Length = 1222 Score = 42.4 bits (98), Expect = 0.001 Identities = 35/150 (23%), Positives = 66/150 (44%), Gaps = 22/150 (14%) Query: 199 LSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLL 258 L+F Y IS I +ATL T++ F + R YP + ++ + + ++L+F + Sbjct: 836 LTFISYIGCGISAIFSAATLLTYVAF--EKLRRDYPSKILMNLSTALLFLNLLFLLD--- 890 Query: 259 EDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVPK 318 +T + + C + ++L+FF +A W + I ++A V K Sbjct: 891 ----------------GWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALV-K 933 Query: 319 WGSEAIEKKALLFHASAWGIPGTLTIILLA 348 + I + L F WG+P + ++LA Sbjct: 934 VFNTYIRRYILKFCIIGWGLPALVVSVVLA 963 >gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] Length = 1522 Score = 42.0 bits (97), Expect = 0.002 Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 13/123 (10%) Query: 281 SHNKA-CTMLFMILYFFTMAGSVWWVILTITW--FLAAVPKWGSEAIEKKALLFHASAWG 337 +HNK+ CT L+FF +A W +LT W ++A K + I K+ F WG Sbjct: 935 THNKSICTTTTAFLHFFFLASFCW--VLTEAWQSYMAVTGKIRTRLIRKR---FLCLGWG 989 Query: 338 IPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISL 397 +P + + + +G C++ L L Y + P V+V ++ GI+ Sbjct: 990 LPALVVATSVGFTRTKGYGTDHYCWLSL--EGGLLYAFVGPAAAVVLVN---MVIGILVF 1044 Query: 398 NRV 400 N++ Sbjct: 1045 NKL 1047 >gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] Length = 870 Score = 41.6 bits (96), Expect = 0.002 Identities = 43/193 (22%), Positives = 78/193 (40%), Gaps = 22/193 (11%) Query: 211 IICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDR--------- 261 I+ +SA L TF T +D Y + + F ++SLI+ + LL + Sbjct: 357 IMYVSAWLLTFPT--MDPKPLAYAIQNVSFDISIVSLISLIWSLAILLLSKKYKQLPHML 414 Query: 262 ----VACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAAVP 317 + + + A + + ++F++LY + +W +L I+ FL Sbjct: 415 TTNLLIAQSIVCAGMMIWNFVKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKK- 473 Query: 318 KWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLA 377 E ++ + S WGIP L +LL K GD+I F Y + + + Sbjct: 474 ---RERVQIPVGIIIISGWGIPALLVGVLLITGKHNGDSIDSAFF---YGKEQMITTAVT 527 Query: 378 PLCLYVVVGVSLL 390 C ++ G+SL+ Sbjct: 528 LFCSILIAGISLM 540 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.140 0.450 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,797,739 Number of Sequences: 37866 Number of extensions: 1177501 Number of successful extensions: 3671 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 27 Number of HSP's successfully gapped in prelim test: 36 Number of HSP's that attempted gapping in prelim test: 3549 Number of HSP's gapped (non-prelim): 105 length of query: 666 length of database: 18,247,518 effective HSP length: 109 effective length of query: 557 effective length of database: 14,120,124 effective search space: 7864909068 effective search space used: 7864909068 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.