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Search of human proteins with 83776596
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
(501 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 998 0.0
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 306 3e-83
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 296 4e-80
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 296 4e-80
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 283 3e-76
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 271 1e-72
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 271 1e-72
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 233 4e-61
gi|27901803 protein serine kinase H1 [Homo sapiens] 220 2e-57
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 216 3e-56
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 216 3e-56
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 216 5e-56
gi|14916455 protein serine kinase H2 [Homo sapiens] 212 7e-55
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 205 9e-53
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 201 1e-51
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 200 2e-51
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 199 6e-51
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 199 6e-51
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 198 8e-51
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 196 3e-50
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 193 3e-49
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 193 3e-49
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 193 3e-49
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 192 5e-49
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 192 8e-49
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 192 8e-49
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 192 8e-49
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 192 8e-49
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 191 1e-48
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 191 1e-48
>gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
Length = 501
Score = 998 bits (2581), Expect = 0.0
Identities = 501/501 (100%), Positives = 501/501 (100%)
Query: 1 MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDG 60
MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDG
Sbjct: 1 MPFGCVTLGDKKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDG 60
Query: 61 RKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSER 120
RKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSER
Sbjct: 61 RKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSER 120
Query: 121 DTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEP 180
DTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEP
Sbjct: 121 DTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKEP 180
Query: 181 CGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKI 240
CGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKI
Sbjct: 181 CGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKI 240
Query: 241 LAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGV 300
LAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGV
Sbjct: 241 LAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGV 300
Query: 301 CAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAAS 360
CAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAAS
Sbjct: 301 CAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAAS 360
Query: 361 GATSAPEGDAARAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTP 420
GATSAPEGDAARAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTP
Sbjct: 361 GATSAPEGDAARAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTP 420
Query: 421 ATDRSATPATDGRATPATEESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAP 480
ATDRSATPATDGRATPATEESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAP
Sbjct: 421 ATDRSATPATDGRATPATEESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAP 480
Query: 481 PSSKGEEAAGYAQESQREEAS 501
PSSKGEEAAGYAQESQREEAS
Sbjct: 481 PSSKGEEAAGYAQESQREEAS 501
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 306 bits (784), Expect = 3e-83
Identities = 156/357 (43%), Positives = 225/357 (63%), Gaps = 12/357 (3%)
Query: 14 YNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGI 73
+ Q ++ D YD V+ T F E+ A+DK T KL K K + +NEI +
Sbjct: 10 WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAV 69
Query: 74 LKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAV 133
L +KHPNI+ L D++ + ++ ++L +G E+FD I+++G+Y+ERD S ++ QVL+AV
Sbjct: 70 LHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAV 129
Query: 134 AYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLEN--GLIKEPCGTPEYLAPEV 191
YLH L IVHR+LK ENL+YY+ ++SKI+ISDF L+K+E+ ++ CGTP Y+APEV
Sbjct: 130 KYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEV 189
Query: 192 VGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPY 251
+ ++ Y + VDCW+IGVI YILL G PPFY+E +D LF +IL +YEFDSPY
Sbjct: 190 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE--------NDAKLFEQILKAEYEFDSPY 241
Query: 252 WDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARA 311
WDDIS +AKD + LME + ++R T E+A+ H WI+G+ A DKNI V QI+KNFA++
Sbjct: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKS 301
Query: 312 KWKKAVRVTTLMKRLRAPE--QSSTAAAQSASATDTATPGAAGGATAAAASGATSAP 366
KWK+A T +++ +R + S Q+AS + TP A G A P
Sbjct: 302 KWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEP 358
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 296 bits (757), Expect = 4e-80
Identities = 142/332 (42%), Positives = 221/332 (66%), Gaps = 10/332 (3%)
Query: 16 QPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
Q ++ ++ + + T F E+ A++K TGKL K K+ + + +NEI +L+
Sbjct: 15 QAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLR 74
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
+KH NI+ L D++ + ++ ++L +G E+FD I+++G+Y+E+D S ++RQVL+AV Y
Sbjct: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYY 134
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLE--NGLIKEPCGTPEYLAPEVVG 193
LH + IVHR+LK ENL+YY++ + SKI+ISDF L+K+E ++ CGTP Y+APEV+
Sbjct: 135 LHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA 194
Query: 194 RQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWD 253
++ Y + VDCW+IGVI YILL G PPFY+E +D LF +IL +YEFDSPYWD
Sbjct: 195 QKPYSKAVDCWSIGVIAYILLCGYPPFYDE--------NDSKLFEQILKAEYEFDSPYWD 246
Query: 254 DISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKW 313
DIS +AKD + LME + ++R T E+A H WI+G+ A +KNI + V AQI KNFA++KW
Sbjct: 247 DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKW 306
Query: 314 KKAVRVTTLMKRLRAPEQSSTAAAQSASATDT 345
++A T +++ +R S+ + +AS + +
Sbjct: 307 RQAFNATAVVRHMRKLHLGSSLDSSNASVSSS 338
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 296 bits (757), Expect = 4e-80
Identities = 142/332 (42%), Positives = 221/332 (66%), Gaps = 10/332 (3%)
Query: 16 QPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
Q ++ ++ + + T F E+ A++K TGKL K K+ + + +NEI +L+
Sbjct: 15 QAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLR 74
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
+KH NI+ L D++ + ++ ++L +G E+FD I+++G+Y+E+D S ++RQVL+AV Y
Sbjct: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYY 134
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLE--NGLIKEPCGTPEYLAPEVVG 193
LH + IVHR+LK ENL+YY++ + SKI+ISDF L+K+E ++ CGTP Y+APEV+
Sbjct: 135 LHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA 194
Query: 194 RQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWD 253
++ Y + VDCW+IGVI YILL G PPFY+E +D LF +IL +YEFDSPYWD
Sbjct: 195 QKPYSKAVDCWSIGVIAYILLCGYPPFYDE--------NDSKLFEQILKAEYEFDSPYWD 246
Query: 254 DISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKW 313
DIS +AKD + LME + ++R T E+A H WI+G+ A +KNI + V AQI KNFA++KW
Sbjct: 247 DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKW 306
Query: 314 KKAVRVTTLMKRLRAPEQSSTAAAQSASATDT 345
++A T +++ +R S+ + +AS + +
Sbjct: 307 RQAFNATAVVRHMRKLHLGSSLDSSNASVSSS 338
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 283 bits (724), Expect = 3e-76
Identities = 157/408 (38%), Positives = 233/408 (57%), Gaps = 16/408 (3%)
Query: 16 QPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
Q + + + +V+ + F E+F K + TGKL K +K + + +NEI +LK
Sbjct: 15 QTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFR-DSSLENEIAVLK 73
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
+KH NI+ L D++ + Y++ ++L +G E+FD IL++G Y+E+D S V++QVL AV Y
Sbjct: 74 KIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKY 133
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLE-NGLIKEPCGTPEYLAPEVVGR 194
LH IVHR+LK ENL+Y +NSKI+I+DF L+K+E NG++ CGTP Y+APEV+ +
Sbjct: 134 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ 193
Query: 195 QRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDD 254
+ Y + VDCW+IGVI YILL G PPFYEE E LF KI G YEF+SP+WDD
Sbjct: 194 KPYSKAVDCWSIGVITYILLCGYPPFYEETE--------SKLFEKIKEGYYEFESPFWDD 245
Query: 255 ISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWK 314
IS++AKD + L+E + ++R T E+A+SH WI GN A ++I V QI+KNFA++KW+
Sbjct: 246 ISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWR 305
Query: 315 KAVRVTTLMKRLRAPEQS--STAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAAR 372
+A ++ +R + S T + ++ T AP D +
Sbjct: 306 QAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPVLDHSV 365
Query: 373 AAKSDNVAPADRSATPATDG--SATPATDGSVTPATDGSITPATDGSV 418
A + P P G S +GS+ S+ P GS+
Sbjct: 366 ALPALTQLPCQHGRRPTAPGGRSLNCLVNGSL--HISSSLVPMHQGSL 411
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 271 bits (692), Expect = 1e-72
Identities = 134/310 (43%), Positives = 204/310 (65%), Gaps = 9/310 (2%)
Query: 19 EVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVK 78
+++ Y++ + + + F E+ A+++ + L K K+ R +NEI +L+ +
Sbjct: 27 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 86
Query: 79 HPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHS 138
HPNI+ L DV + ++ +EL TG E+FD I+++G Y+E+D S++V QVL AV+YLHS
Sbjct: 87 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 146
Query: 139 LKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENG-LIKEPCGTPEYLAPEVVGRQRY 197
L IVHR+LK ENL+Y ++SKI++SDF L+K++ G ++ CGTP Y+APE++ ++ Y
Sbjct: 147 LGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPY 206
Query: 198 GRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQ 257
G+ VD WA+GVI YILL G PPFY+E D LF +IL YEFDSP+WDDIS+
Sbjct: 207 GKAVDVWALGVISYILLCGYPPFYDE--------SDPELFSQILRASYEFDSPFWDDISE 258
Query: 258 AAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAV 317
+AKD + L+E + +R T ++A+ H WISG+ A D++I V QI KNFAR WK+A
Sbjct: 259 SAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAF 318
Query: 318 RVTTLMKRLR 327
T+ ++ +R
Sbjct: 319 NATSFLRHIR 328
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 271 bits (692), Expect = 1e-72
Identities = 134/310 (43%), Positives = 204/310 (65%), Gaps = 9/310 (2%)
Query: 19 EVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVK 78
+++ Y++ + + + F E+ A+++ + L K K+ R +NEI +L+ +
Sbjct: 93 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 152
Query: 79 HPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHS 138
HPNI+ L DV + ++ +EL TG E+FD I+++G Y+E+D S++V QVL AV+YLHS
Sbjct: 153 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 212
Query: 139 LKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENG-LIKEPCGTPEYLAPEVVGRQRY 197
L IVHR+LK ENL+Y ++SKI++SDF L+K++ G ++ CGTP Y+APE++ ++ Y
Sbjct: 213 LGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPY 272
Query: 198 GRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQ 257
G+ VD WA+GVI YILL G PPFY+E D LF +IL YEFDSP+WDDIS+
Sbjct: 273 GKAVDVWALGVISYILLCGYPPFYDE--------SDPELFSQILRASYEFDSPFWDDISE 324
Query: 258 AAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAV 317
+AKD + L+E + +R T ++A+ H WISG+ A D++I V QI KNFAR WK+A
Sbjct: 325 SAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAF 384
Query: 318 RVTTLMKRLR 327
T+ ++ +R
Sbjct: 385 NATSFLRHIR 394
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 233 bits (593), Expect = 4e-61
Identities = 133/339 (39%), Positives = 202/339 (59%), Gaps = 14/339 (4%)
Query: 38 IFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKHPNILQLVDVFVTRKEYFI 97
++R K K T K + K +K +K+ + EIG+L + HPNI++L ++F T E +
Sbjct: 60 VYRCKQKGTQKPYALKVLKKTVDKKI---VRTEIGVLLRLSHPNIIKLKEIFETPTEISL 116
Query: 98 FLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSLKIVHRNLKLENLVYYNRL 157
LEL TG E+FD I+++GYYSERD ++ V+Q+LEAVAYLH IVHR+LK ENL+Y
Sbjct: 117 VLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPA 176
Query: 158 KNSKIVISDFHLAKL--ENGLIKEPCGTPEYLAPEVVGRQRYGRPVDCWAIGVIMYILLS 215
++ + I+DF L+K+ L+K CGTP Y APE++ YG VD W++G+I YILL
Sbjct: 177 PDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLC 236
Query: 216 GNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQAAKDLVTRLMEVEQDQRI 275
G PFY+ E D+ +FR+IL +Y F SP+WD++S AKDLV +L+ ++ +R+
Sbjct: 237 GFEPFYD-------ERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRL 289
Query: 276 TAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAVRVTTLMKRLRAPEQSSTA 335
T +A+ H W++G AA+ ++ D ++++ AR K K AV+ RL + S +
Sbjct: 290 TTFQALQHPWVTGKAANFVHM-DTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGS 348
Query: 336 AAQSASATDTATPGAAGGATAAAASGATSAPEGDAARAA 374
+S A+ +P G A +GD A+AA
Sbjct: 349 IQESHKASRDPSPIQDGNEDMKAIPEGEKI-QGDGAQAA 386
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 220 bits (561), Expect = 2e-57
Identities = 125/316 (39%), Positives = 194/316 (61%), Gaps = 16/316 (5%)
Query: 20 VTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKH 79
VT +YD+ +I F + R + + T + + K + + R+ R+ ++E+ +L+ V+H
Sbjct: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKY-REGREVCESELRVLRRVRH 152
Query: 80 PNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSL 139
NI+QLV+VF T++ ++ +ELATG E+FD I+ +G ++ERD + V++ VL+ V YLH+L
Sbjct: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212
Query: 140 KIVHRNLKLENLVYYNRLKNSKIVISDFHLA----KLENGLIKEPCGTPEYLAPEVVGRQ 195
I HR+LK ENL+YY+ +SKI+I+DF LA K ++ L+K CGTPEY+APEV+ R+
Sbjct: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272
Query: 196 RYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDI 255
Y VD WA+GVI YILLSG PF EDD + L+R+IL G Y + W +
Sbjct: 273 PYTNSVDMWALGVIAYILLSGTMPF-----EDD---NRTRLYRQILRGKYSYSGEPWPSV 324
Query: 256 SQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASD--KNIKDGVCAQIEKN-FARAK 312
S AKD + RL+ V+ R+TA +A+ H W+ AAS KN+ + + K +R +
Sbjct: 325 SNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQ 384
Query: 313 WKKAVRVTTLMKRLRA 328
K+ + T + R+
Sbjct: 385 STKSAQSTRSSRSTRS 400
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 216 bits (551), Expect = 3e-56
Identities = 120/336 (35%), Positives = 186/336 (55%), Gaps = 7/336 (2%)
Query: 15 NQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGIL 74
++ S + ++Y +G+VI F + D++TGK K K +NE+ IL
Sbjct: 384 SESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 443
Query: 75 KMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVA 134
+ VKHPNI+ LV+ T E F+ +EL G ++FD I Y+ERD S +V + A+
Sbjct: 444 RRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALR 503
Query: 135 YLHSLKIVHRNLKLENLVYYNRLKNSK-IVISDFHLAKLENGLIKEPCGTPEYLAPEVVG 193
YLH L IVHR++K ENL+ +K + + DF LA + G + CGTP Y+APE++
Sbjct: 504 YLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIA 563
Query: 194 RQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWD 253
YG VD WA GVI YILL G PPF E N ++LF +ILAG EF +PYWD
Sbjct: 564 ETGYGLKVDIWAAGVITYILLCGFPPFRSE------NNLQEDLFDQILAGKLEFPAPYWD 617
Query: 254 DISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKW 313
+I+ +AK+L++++++V + R TA + +SH W+S +A+ + N++ V +++++F A
Sbjct: 618 NITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALP 677
Query: 314 KKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPG 349
K+ T + + S D+ PG
Sbjct: 678 KQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPG 713
Score = 30.4 bits (67), Expect = 3.9
Identities = 16/52 (30%), Positives = 23/52 (44%)
Query: 439 EESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAPPSSKGEEAAG 490
++S P + + + P P A P T PE T PP++ G E AG
Sbjct: 707 QDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAG 758
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 216 bits (551), Expect = 3e-56
Identities = 120/336 (35%), Positives = 186/336 (55%), Gaps = 7/336 (2%)
Query: 15 NQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGIL 74
++ S + ++Y +G+VI F + D++TGK K K +NE+ IL
Sbjct: 385 SESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 444
Query: 75 KMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVA 134
+ VKHPNI+ LV+ T E F+ +EL G ++FD I Y+ERD S +V + A+
Sbjct: 445 RRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALR 504
Query: 135 YLHSLKIVHRNLKLENLVYYNRLKNSK-IVISDFHLAKLENGLIKEPCGTPEYLAPEVVG 193
YLH L IVHR++K ENL+ +K + + DF LA + G + CGTP Y+APE++
Sbjct: 505 YLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIA 564
Query: 194 RQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWD 253
YG VD WA GVI YILL G PPF E N ++LF +ILAG EF +PYWD
Sbjct: 565 ETGYGLKVDIWAAGVITYILLCGFPPFRSE------NNLQEDLFDQILAGKLEFPAPYWD 618
Query: 254 DISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKW 313
+I+ +AK+L++++++V + R TA + +SH W+S +A+ + N++ V +++++F A
Sbjct: 619 NITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALP 678
Query: 314 KKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPG 349
K+ T + + S D+ PG
Sbjct: 679 KQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPG 714
Score = 30.4 bits (67), Expect = 3.9
Identities = 16/52 (30%), Positives = 23/52 (44%)
Query: 439 EESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGATGQAPPSSKGEEAAG 490
++S P + + + P P A P T PE T PP++ G E AG
Sbjct: 708 QDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAG 759
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 216 bits (549), Expect = 5e-56
Identities = 116/335 (34%), Positives = 184/335 (54%), Gaps = 24/335 (7%)
Query: 11 KKNYNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNE 70
++ + P+ +T+RY +G+ I F + +++T + + K +K R +NE
Sbjct: 377 EEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNE 436
Query: 71 IGILKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVL 130
+ IL+ VKHPNI+ L++ E ++ +EL G ++FD I Y+ERD S ++ +
Sbjct: 437 VSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLA 496
Query: 131 EAVAYLHSLKIVHRNLKLENLVYYNRLKNSK-IVISDFHLAKLENGLIKEPCGTPEYLAP 189
A+ YLHSL IVHR++K ENL+ Y SK + + DF LA + +G + CGTP Y+AP
Sbjct: 497 SAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAP 556
Query: 190 EVVGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDS 249
E++ YG VD WA GVI YILL G PPF ++ + LF +IL G +F S
Sbjct: 557 EIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV------LFDQILMGQVDFPS 610
Query: 250 PYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFA 309
PYWD++S +AK+L+T ++ V+ DQR +A + + H W++ + + + V +I+K+F
Sbjct: 611 PYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFN 670
Query: 310 RAKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATD 344
P+ +STAA S A D
Sbjct: 671 -----------------TGPKPNSTAAGVSVIALD 688
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 212 bits (539), Expect = 7e-55
Identities = 123/327 (37%), Positives = 187/327 (57%), Gaps = 30/327 (9%)
Query: 20 VTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVKH 79
V RYD+ +I T F + R + KTT K K + R+ R+ R+A +E+ +L+ V H
Sbjct: 59 VLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETRE-REGREACVSELSVLRRVSH 117
Query: 80 PNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHSL 139
I+QL+++F T + ++ +ELATG E+FD ++ QG ++ERD +++ V + + YLH+L
Sbjct: 118 RYIVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHAL 177
Query: 140 KIVHRNLKLENLVYYNRLKNSKIVISDFHLA----KLENGLIKEPCGTPEYLAPEVVGRQ 195
+I HRNLK ENL+YY+ + SKI+I+DF LA K + +K CGTPEY+APEV+ R+
Sbjct: 178 QITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRK 237
Query: 196 RYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDI 255
Y VD WA+GVI Y LLSG PF +E + L+RKIL G Y + W I
Sbjct: 238 PYTSAVDMWALGVITYALLSGFLPFDDESQ--------TRLYRKILKGKYNYTGEPWPSI 289
Query: 256 SQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKK 315
S AKD + +L+ +E R++A +A+ H W+ AA KN RA
Sbjct: 290 SHLAKDFIDKLLILEAGHRMSAGQALDHPWVITMAAGSS----------MKNLQRA---- 335
Query: 316 AVRVTTLMKRLRAPEQSSTAAAQSASA 342
++ + + +P S +AQS+ +
Sbjct: 336 ---ISRNLMQRASPHSQSPGSAQSSKS 359
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 205 bits (521), Expect = 9e-53
Identities = 149/481 (30%), Positives = 231/481 (48%), Gaps = 29/481 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L R + + +TA A TA G G A S +G
Sbjct: 299 KLKGAILTTMLATRNFSVGRQTTAPA----TMSTAASGTTMGLVEQAKSLLNKKADGVKP 354
Query: 372 RAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTPATDRSA-TPAT 430
+ + N A A + P T P DG I ++D + T D A P
Sbjct: 355 QTNSTKNSAAATSPKGTLPPAALEPQTTVIHNP-VDG-IKESSDSANTTIEDEDAKAPRV 412
Query: 431 DGRATPATEESTVPTTQSSAMLATKAAATPEPAMAQPDSTAPEGA-TGQAPPSSKGEEAA 489
+ S P + + A +P PA + S G P ++G +A
Sbjct: 413 PDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSA 472
Query: 490 G 490
G
Sbjct: 473 G 473
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 201 bits (512), Expect = 1e-51
Identities = 132/385 (34%), Positives = 205/385 (53%), Gaps = 33/385 (8%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTT-----GKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R KT+ K+ KK RD +K+ + A+ I +
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ + Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
+H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA++A+ H W+ + + + + F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 312 KWKKAVRVTTLMKR-LRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDA 370
K K A+ T L+ R QSS A+ +AS AAG A AA S +G
Sbjct: 299 KLKGAILTTMLVSRNFSVGRQSSAPASPAAS--------AAGLAGQAAKSLLNKKSDGGV 350
Query: 371 ARAAKSDNV---APADRSATPATDG 392
+ S +V P ATDG
Sbjct: 351 KKRKSSSSVHLMEPQTTVVHNATDG 375
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 200 bits (509), Expect = 2e-51
Identities = 136/415 (32%), Positives = 210/415 (50%), Gaps = 27/415 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L R + + +TA A TA G G A S +G
Sbjct: 299 KLKGAILTTMLATRNFSVGRQTTAPA----TMSTAASGTTMGLVEQAKSLLNKKADGVKP 354
Query: 372 RAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDGSVTPATDRSA 426
+ + N A A + P T P DG I ++D + T D A
Sbjct: 355 QTNSTKNSAAATSPKGTLPPAALEPQTTVIHNP-VDG-IKESSDSANTTIEDEDA 407
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 199 bits (505), Expect = 6e-51
Identities = 121/340 (35%), Positives = 192/340 (56%), Gaps = 28/340 (8%)
Query: 21 TDRYDLGQVIKTEEFCEIFR-----AKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
T+ Y L + + F + R A + K+ KK RD +K+ + A+ I +
Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREAR----ICR 65
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 66 LLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 125
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++LK + + ++DF LA G + GTP YL+PEV+
Sbjct: 126 CHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------RLYQQIKAGAYDFPSPEW 237
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWIS--GNAASDKNIKDGVCAQIEKNFAR 310
D ++ AKDL+ +++ + +RITA EA+ H WIS AS + ++ V ++K AR
Sbjct: 238 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDC-LKKFNAR 296
Query: 311 AKWKKAVRVTTLMKR-----LRAPEQSSTAAAQSASATDT 345
K K A+ T L R + S +S+ +T+T
Sbjct: 297 RKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNT 336
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 199 bits (505), Expect = 6e-51
Identities = 129/406 (31%), Positives = 205/406 (50%), Gaps = 22/406 (5%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L R + + +TA A ++A T G A + A E
Sbjct: 299 KLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKEPQTT 358
Query: 372 RAAKS-DNVAPADRSATPATDGSATPATDGSVTPATDGSITPATDG 416
D + + SA + A + T+ I +G
Sbjct: 359 VIHNPVDGIKESSDSANTTIEDEDAKARKQEIIKTTEQLIEAVNNG 404
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 198 bits (504), Expect = 8e-51
Identities = 117/315 (37%), Positives = 183/315 (58%), Gaps = 23/315 (7%)
Query: 21 TDRYDLGQVIKTEEFCEIFR-----AKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
T+ Y L + + F + R A + K+ KK RD +K+ + A+ I +
Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREAR----ICR 65
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 66 LLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 125
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++LK + + ++DF LA G + GTP YL+PEV+
Sbjct: 126 CHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 185
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 186 RKDPYGKPVDLWACGVILYILLVGYPPFWDEDQH--------RLYQQIKAGAYDFPSPEW 237
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWIS--GNAASDKNIKDGVCAQIEKNFAR 310
D ++ AKDL+ +++ + +RITA EA+ H WIS AS + ++ V ++K AR
Sbjct: 238 DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDC-LKKFNAR 296
Query: 311 AKWKKAVRVTTLMKR 325
K K A+ T L R
Sbjct: 297 RKLKGAILTTMLATR 311
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 196 bits (499), Expect = 3e-50
Identities = 125/391 (31%), Positives = 202/391 (51%), Gaps = 31/391 (7%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKR----------LRAPEQSSTAAAQSASATDTATPGAAGGATAAAASG 361
K K A+ T L R +A + SA T+ G A ++
Sbjct: 299 KLKGAILTTMLATRNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALESSDS 358
Query: 362 ATSAPEGDAARAAKSDNVAPADRSATPATDG 392
A + E + A+A K + + ++ +G
Sbjct: 359 ANTTIEDEDAKARKQEIIKTTEQLIEAVNNG 389
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 193 bits (491), Expect = 3e-49
Identities = 124/381 (32%), Positives = 201/381 (52%), Gaps = 35/381 (9%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L A ++ SA + A G ++ S T+ + D A
Sbjct: 299 KLKGAILTTML-------------ATRNFSAAKSLLNKKADGVKESSDSANTTIEDED-A 344
Query: 372 RAAKSDNVAPADRSATPATDG 392
+A K + + ++ +G
Sbjct: 345 KARKQEIIKTTEQLIEAVNNG 365
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 193 bits (491), Expect = 3e-49
Identities = 123/363 (33%), Positives = 195/363 (53%), Gaps = 30/363 (8%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L R + +AA+ S + G + S A ++P+G
Sbjct: 299 KLKGAILTTMLATR-------NFSAAK--SLLNKKADGVKPQTNSTKNSAAATSPKGTLP 349
Query: 372 RAA 374
AA
Sbjct: 350 PAA 352
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 193 bits (490), Expect = 3e-49
Identities = 121/363 (33%), Positives = 192/363 (52%), Gaps = 31/363 (8%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L +T + S + G + S A ++P+G
Sbjct: 299 KLKGAILTTML----------ATRNFSAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLP 348
Query: 372 RAA 374
AA
Sbjct: 349 PAA 351
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 192 bits (489), Expect = 5e-49
Identities = 142/456 (31%), Positives = 226/456 (49%), Gaps = 60/456 (13%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTT-----GKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R KT+ K+ KK RD +K+ + A+ I +
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ + Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
+H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA++A+ H W+ + + + + F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 312 KWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDAA 371
K K A+ T L+ R ++A + GG + +
Sbjct: 299 KLKGAILTTMLVSR------------NFSAAKSLLNKKSDGGVKPQSNN----------- 335
Query: 372 RAAKSDNVAPADRSATPATDGSATPATDGSVTPATDGSITPATD--GSVTPATDRSATPA 429
K+ V+PA PA +A V ATDG I +T+ + T D A P
Sbjct: 336 ---KNSLVSPAQE---PAPLQTAMEPQTTVVHNATDG-IKGSTESCNTTTEDEDLKAAPL 388
Query: 430 TDGRATPATEESTVPTTQSSA-MLATKAAATPEPAM 464
G S+VP +SS A A P+P++
Sbjct: 389 RTGNG------SSVPEGRSSRDRTAPSAGMQPQPSL 418
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 192 bits (487), Expect = 8e-49
Identities = 111/314 (35%), Positives = 179/314 (57%), Gaps = 21/314 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTT-----GKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R KT+ K+ KK RD +K+ + A+ I +
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ + Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
+H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA++A+ H W+ + + + + F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 312 KWKKAVRVTTLMKR 325
K K A+ T L+ R
Sbjct: 299 KLKGAILTTMLVSR 312
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 192 bits (487), Expect = 8e-49
Identities = 111/314 (35%), Positives = 179/314 (57%), Gaps = 21/314 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTT-----GKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R KT+ K+ KK RD +K+ + A+ I +
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ + Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
+H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA++A+ H W+ + + + + F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 312 KWKKAVRVTTLMKR 325
K K A+ T L+ R
Sbjct: 299 KLKGAILTTMLVSR 312
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 192 bits (487), Expect = 8e-49
Identities = 111/314 (35%), Positives = 179/314 (57%), Gaps = 21/314 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTT-----GKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R KT+ K+ KK RD +K+ + A+ I +
Sbjct: 11 TDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ + Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
+H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 IHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA++A+ H W+ + + + + F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARR 298
Query: 312 KWKKAVRVTTLMKR 325
K K A+ T L+ R
Sbjct: 299 KLKGAILTTMLVSR 312
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 192 bits (487), Expect = 8e-49
Identities = 113/314 (35%), Positives = 177/314 (56%), Gaps = 21/314 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + I F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KH NI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LEAV +
Sbjct: 67 LLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H + +VHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
++ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKEAYGKPVDIWACGVILYILLVGYPPFWDEDQH--------KLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNF-ARA 311
D ++ AK+L+ +++ + +RITA EA+ H W+ + + + K F AR
Sbjct: 239 DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARR 298
Query: 312 KWKKAVRVTTLMKR 325
K K A+ T L R
Sbjct: 299 KLKGAILTTMLATR 312
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 191 bits (486), Expect = 1e-48
Identities = 122/348 (35%), Positives = 195/348 (56%), Gaps = 35/348 (10%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQH--------RLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI--SGNAASDKNIKDGVCAQIEKNFAR 310
D ++ AKDL+ +++ + +RITA EA+ H WI AS + ++ V ++K AR
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC-LKKFNAR 297
Query: 311 AKWKKAVRVTTLMKR--------LRAPE----QSSTAAAQSASATDTA 346
K K A+ T L R L+ P+ + S+++ Q +T+++
Sbjct: 298 RKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESS 345
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 191 bits (486), Expect = 1e-48
Identities = 126/382 (32%), Positives = 200/382 (52%), Gaps = 24/382 (6%)
Query: 21 TDRYDLGQVIKTEEFCEIFRAKDKTTG-----KLHTCKKFQKRDGRKVRKAAKNEIGILK 75
TD Y L + + F + R TG K+ KK RD +K+ + A+ I +
Sbjct: 11 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR----ICR 66
Query: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
++KHPNI++L D +++ +L TG E+F+ I+ + YYSE D S+ ++Q+LE+V +
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENGLIKE---PCGTPEYLAPEVV 192
H IVHR+LK ENL+ ++ K + + ++DF LA G + GTP YL+PEV+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186
Query: 193 GRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYW 252
+ YG+PVD WA GVI+YILL G PPF++E + L+++I AG Y+F SP W
Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQH--------RLYQQIKAGAYDFPSPEW 238
Query: 253 DDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI--SGNAASDKNIKDGVCAQIEKNFAR 310
D ++ AKDL+ +++ + +RITA EA+ H WI AS + ++ V ++K AR
Sbjct: 239 DTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC-LKKFNAR 297
Query: 311 AKWKKAVRVTTLMKRLRAPEQSSTAAAQSASATDTATPGAAGGATAAAASGATSAPEGDA 370
K K A+ T L R + +S T G + S T+ + D
Sbjct: 298 RKLKGAILTTMLATRNFSAAKSLLKKPDGVKEPQTTVIHNPDGNKESTESSNTTIEDED- 356
Query: 371 ARAAKSDNVAPADRSATPATDG 392
+A K + + ++ +G
Sbjct: 357 VKARKQEIIKVTEQLIEAINNG 378
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,279,096
Number of Sequences: 37866
Number of extensions: 914317
Number of successful extensions: 15854
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 906
Number of HSP's that attempted gapping in prelim test: 6278
Number of HSP's gapped (non-prelim): 5069
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.