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Search of human proteins with 78042577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78042577 MAP7 domain containing 1 [Homo sapiens]
(841 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 1674 0.0
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 391 e-108
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 209 7e-54
gi|147903302 MAP7 domain containing 3 [Homo sapiens] 176 6e-44
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 114 5e-25
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 110 5e-24
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 107 5e-23
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 98 3e-20
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 98 4e-20
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens] 96 1e-19
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens] 96 1e-19
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens] 96 1e-19
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 89 1e-17
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 89 2e-17
gi|148746195 trichohyalin [Homo sapiens] 88 4e-17
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 86 1e-16
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 86 2e-16
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 85 2e-16
gi|56549694 enabled homolog isoform a [Homo sapiens] 83 9e-16
gi|39930375 enabled homolog isoform b [Homo sapiens] 83 9e-16
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 83 9e-16
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 83 9e-16
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 83 9e-16
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 83 9e-16
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 83 9e-16
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 83 1e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 2e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 2e-15
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 82 2e-15
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 82 2e-15
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 1674 bits (4334), Expect = 0.0
Identities = 841/841 (100%), Positives = 841/841 (100%)
Query: 1 MESGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATS 60
MESGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATS
Sbjct: 1 MESGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATS 60
Query: 61 SKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV 120
SKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV
Sbjct: 61 SKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV 120
Query: 121 PASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR 180
PASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR
Sbjct: 121 PASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR 180
Query: 181 RLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHS 240
RLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHS
Sbjct: 181 RLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHS 240
Query: 241 SPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRL 300
SPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRL
Sbjct: 241 SPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRL 300
Query: 301 MTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPV 360
MTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPV
Sbjct: 301 MTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPV 360
Query: 361 CPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDK 420
CPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDK
Sbjct: 361 CPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDK 420
Query: 421 ERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASP 480
ERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASP
Sbjct: 421 ERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASP 480
Query: 481 CPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESA 540
CPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESA
Sbjct: 481 CPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESA 540
Query: 541 APASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEAT 600
APASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEAT
Sbjct: 541 APASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEAT 600
Query: 601 RLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEARE 660
RLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEARE
Sbjct: 601 RLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEARE 660
Query: 661 KAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTR 720
KAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTR
Sbjct: 661 KAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTR 720
Query: 721 KSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKEL 780
KSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKEL
Sbjct: 721 KSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKEL 780
Query: 781 PASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSPQVTEV 840
PASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSPQVTEV
Sbjct: 781 PASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSPQVTEV 840
Query: 841 L 841
L
Sbjct: 841 L 841
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 391 bits (1005), Expect = e-108
Identities = 269/648 (41%), Positives = 353/648 (54%), Gaps = 95/648 (14%)
Query: 123 SDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL 182
S + P V + +R +LA+ERREER K LAA++ VWLE+EE+A+ EK L+ER++RL
Sbjct: 51 SGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL 110
Query: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWA-EIRQQRWSWAGALHHSS 241
EEQR K E+RRAA+EE++RQ+LE++KER+EA ++R+++++ + + RWSW G+LH S
Sbjct: 111 EEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSP 170
Query: 242 PGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLM 301
H R SVS +NL K+VD +I+KRLS SSATL NSP R R LQLS WESS+V+RL+
Sbjct: 171 SIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLL 230
Query: 302 TPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVC 361
TPT SFLARS+S L
Sbjct: 231 TPTHSFLARSKSTAALSGE----------------------------------------- 249
Query: 362 PRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKE 421
+AS SP+ + A R +P +P R KK++E
Sbjct: 250 --AASCSPI--------IMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERE 299
Query: 422 RENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPC 481
REN ++ R R P++P+AR A S L SK+ P P T RP S
Sbjct: 300 RENVLFLTSGTR------RAVSPSNPKARQPAR--SRLWLPSKSLPHLPGTP--RPTSSL 349
Query: 482 PSPG-----PGHTLPPKPPSPRGTTASPKGRVRRKEEAKE------SPSAAGPEDKSQSK 530
P PG P PP P + R K +K+ KE PS G + +
Sbjct: 350 P-PGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVE 408
Query: 531 RRASNEKESA----APASPAPSPAPSPTPAPPQKEQP-PAETPTDAAVLTSPPAPAPPVT 585
E+ A PA+PA +PAP+ PAP P P TP A++++P +
Sbjct: 409 EATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTP---AMVSAPSSTVNASA 465
Query: 586 PSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEAR-A 644
K AGTTD EEATRLLAEKRR AREQRE+EE+ERR Q E +++ REE R AE R
Sbjct: 466 SVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTT 525
Query: 645 EREAEARRREEQEAREK-----------AQAEQEEQERLQKQKEEAEARSREEAERQRLE 693
RE E+RR E ++AREK A E+EE ER Q+QKEE EAR REEAER R E
Sbjct: 526 RREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE-EARVREEAERVRQE 584
Query: 694 REKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGS 741
REKHFQ++EQER ER+KRLEEIMKRTR++E ++ K A G+
Sbjct: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGA 632
Score = 67.0 bits (162), Expect = 7e-11
Identities = 64/237 (27%), Positives = 105/237 (44%), Gaps = 30/237 (12%)
Query: 14 PPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSG 73
PP V P + RP G+ P + V P P + + + L+ +P
Sbjct: 350 PPGSVKAAPAQVRPPSPGNIRP----VKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLV 405
Query: 74 QVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV--PASDSPPT--- 128
+V A +E +P+ GP PAM P A P +S P+P V PA S P+
Sbjct: 406 KV--EEATVEERTPAEPEV--GPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTV 461
Query: 129 ---------------KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREK 173
++ + E+ +LA+E+RE+ + ++ + +K E+ A R
Sbjct: 462 NASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVA 520
Query: 174 QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKN-KERYEAAIQRSVKKTWAEIRQQ 229
+ + RR E +RL+AEQ R E+ QRQ E+ +ER EA + K+ A +R++
Sbjct: 521 EERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREE 577
Score = 50.8 bits (120), Expect = 5e-06
Identities = 66/288 (22%), Positives = 122/288 (42%), Gaps = 36/288 (12%)
Query: 8 ELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPL- 66
E+G AP A P P+P P+P P P A+V P + NA++S +
Sbjct: 421 EVGPAAPAMAPA---PASAPAPASAPAPAPVPTPAMV-----SAPSSTVNASASVKTSAG 472
Query: 67 --EPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASD 124
+PE + + + +E+ E + R R+ R + + + S
Sbjct: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEES- 531
Query: 125 SPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
+ E ++A E+ + + + EERA E+EE +A R+K+ +E R R E
Sbjct: 532 ---RRLEAEQAREKEEQLQRQAEERALR---------EREEAERAQRQKE-EEARVREEA 578
Query: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHS--SP 242
+R++ ++R + ++++LE+ K E I + ++T A ++ G + +
Sbjct: 579 ERVR-QEREKHFQREEQERLERKKRLEE--IMKRTRRTEATDKKTSDQRNGDIAKGALTG 635
Query: 243 GHKTSGSRCSVSA------VNLPKHVDSIINKRLSKSSATLWNSPSRN 284
G + S C+ +A V P V S +K +S+ L P+ N
Sbjct: 636 GTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNEN 683
Score = 37.4 bits (85), Expect = 0.059
Identities = 26/110 (23%), Positives = 56/110 (50%), Gaps = 14/110 (12%)
Query: 667 EEQERLQKQKEEAEARSREEAERQRLERE-KHFQQQEQERQERRKRLEEIMKRTRKSEVS 725
++++RL +++ REE E+Q RE +++E+ RQ K LEE RK +
Sbjct: 64 DDRQRLARER-------REEREKQLAAREIVWLEREERARQHYEKHLEE-----RKKRLE 111
Query: 726 ETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQK-EEPIPQEPQWS 774
E +QK++ + A + ++ + R + + +++ ++P + +WS
Sbjct: 112 EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWS 161
Score = 35.4 bits (80), Expect = 0.22
Identities = 24/95 (25%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK 710
R+R +E RE+ + + +E + ++EE R+R+ E+ ER+K ++Q Q+ E R+
Sbjct: 66 RQRLARERREEREKQLAAREIVWLEREE---RARQHYEKHLEERKKRLEEQRQK--EERR 120
Query: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745
R ++ R+ + E K++ ++ S +P
Sbjct: 121 R--AAVEEKRRQRLEEDKERHEAVVRRTMERSQKP 153
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 209 bits (533), Expect = 7e-54
Identities = 202/690 (29%), Positives = 308/690 (44%), Gaps = 175/690 (25%)
Query: 94 RGPTPPAMGPRDARPPRRSSQPSPTAVPASDS-------PPTKQEVKKAGERHKLAKERR 146
RG G R R +S P A P + P + K+ ER +LAKERR
Sbjct: 3 RGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKERR 62
Query: 147 EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEK 206
EER K LAA++ LEK+++A+ EKQ++ER R+LEEQR + +Q+RAA+EE+++QKL +
Sbjct: 63 EEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLRE 122
Query: 207 NKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSII 266
E ++ ++++ +Q +
Sbjct: 123 E----EERLEAMMRRSLERTQQLE-----------------------------------L 143
Query: 267 NKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGR 326
K+ S W +P L + D+L T T+S LP+
Sbjct: 144 KKKYS------WGAP-----LAIGPGGHDACDKLSTSTMS----------LPK------- 175
Query: 327 GCDPGRGPTWGRAGAS-LARGPQPDRTHPSAAVPVCPRSASASPLTPC---SVTRSVHR- 381
P P R +S +A PDR VCPR A PL P S TR++ +
Sbjct: 176 ---PTEPPMNKRLSSSTVAISYSPDRVFH-----VCPRLAPLGPLNPSYKSSPTRNIEKK 227
Query: 382 ------CAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARER 435
+ AG+ G ++ +GG EAS V+K ++ + + + + R
Sbjct: 228 KATSTSTSGAGDVG--KEALSGG---------EASLVEKVKRGQRTATSLPVVNFGSPLR 276
Query: 436 SLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPP 495
+ +P P + + + TA+ KA P SP T+ P P + LP
Sbjct: 277 RCEFSGGIPKRPSSPVISKTAT------KAYPQSPKTT----KPPYPGSPVKYRLPALSG 326
Query: 496 SPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTP 555
+ K + ++ E + AAGP+ + ++ ++ S A+ A A +
Sbjct: 327 QDMPKRKAEKEKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAEN--- 383
Query: 556 APPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQRE 615
+A L KP AGTTD EA ++LAEKRRQAR Q+E
Sbjct: 384 ---------------SAAL------------GKPTAGTTDAGEAAKILAEKRRQARLQKE 416
Query: 616 REEQER---------------------RLQAERDKRMREEQLAREAEARAEREAEARRRE 654
+EEQER RL+ E + R +EE+ R+ E + ++E E +R+
Sbjct: 417 QEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEGEEKRKA 476
Query: 655 EQEAREKAQAE--------QEEQER--LQKQKEEAEARSREEAERQRLEREKHFQQQEQE 704
+EA+ KA+ E QE+QE+ ++KQKE AE ++RE AE+ RLERE+ Q EQE
Sbjct: 477 GEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLEREQIMLQIEQE 536
Query: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSK 734
R ER+KR++EIMKRTRKS+V +K+D K
Sbjct: 537 RLERKKRIDEIMKRTRKSDVPPQVKKEDPK 566
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/185 (27%), Positives = 73/185 (39%), Gaps = 18/185 (9%)
Query: 49 PDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP 108
P +P K AT + P+SP P P P + + + P A + +
Sbjct: 288 PSSPVISKTATKAY-----PQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKE 342
Query: 109 PRRSSQPSPTAVPASDSPPTKQEVKK-AGERHKLAKERREERAKYLAAKKAVWLEKEEKA 167
R + A P + K V K A E+H A + E + L A + E A
Sbjct: 343 -REGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAA 401
Query: 168 KALREK----------QLQERRRRLEEQRLKAEQ-RRAALEERQRQKLEKNKERYEAAIQ 216
K L EK + QER + E+ RL+ E+ +R A EER R + E K+ E Q
Sbjct: 402 KILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQ 461
Query: 217 RSVKK 221
KK
Sbjct: 462 EEEKK 466
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/111 (21%), Positives = 57/111 (51%), Gaps = 13/111 (11%)
Query: 665 EQEEQERLQKQKEEAEARSREEAERQRLEREKHFQ-QQEQERQERRKRLEEIMKRTRKSE 723
+ +E++RL K++ E + E+Q LE++K + Q E++ +ER ++LE
Sbjct: 50 KSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLE---------- 99
Query: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWS 774
E +Q++D K A + ++ E R + + ++++ + + + ++S
Sbjct: 100 --EQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYS 148
Score = 40.0 bits (92), Expect = 0.009
Identities = 48/250 (19%), Positives = 94/250 (37%), Gaps = 25/250 (10%)
Query: 6 RAELGAGAPPA----VVARTPPEPRPSPEGDPSPPPP--PMSALVPDTPPDTPPAMK--- 56
R E G P V+++T + P PP P P+ +P P K
Sbjct: 277 RCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEK 336
Query: 57 ---NATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTP--------PAMGPRD 105
N L + P G+ + + A + G P G D
Sbjct: 337 EKSNKEREGTLAQQAAGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTD 396
Query: 106 ARPPRRSSQPSPTAVPASDSPPTKQEVKKAG----ERHKLAKERREERAKYLAAKKAVWL 161
A + ++ V+K ER +L ++ EER + +
Sbjct: 397 AGEAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE 456
Query: 162 EKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK-ERYEAAIQRSVK 220
E++ + + ++++ +E+R+ EE + KAE+ E+++++K EK E+ + A + +
Sbjct: 457 ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAR 516
Query: 221 KTWAEIRQQR 230
+ ++R +R
Sbjct: 517 EVAEQMRLER 526
>gi|147903302 MAP7 domain containing 3 [Homo sapiens]
Length = 876
Score = 176 bits (447), Expect = 6e-44
Identities = 199/718 (27%), Positives = 316/718 (44%), Gaps = 114/718 (15%)
Query: 107 RPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWL-EKEE 165
R SS T P D K ++K+ +LA+ERREE+ + A K L EKE
Sbjct: 42 RVATHSSNIRSTFKPVIDGSMLKNDIKQ-----RLARERREEKRRQQDANKETQLLEKER 96
Query: 166 KAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWA- 224
K K EKQ++ER+R+L+E++ K EQRR A EE++ QK E KE++ A + R++++
Sbjct: 97 KTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLA 156
Query: 225 -EIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSR 283
+ +Q+RWSW G+ +S KT+ R S S L + ++I +++ SSA L NS ++
Sbjct: 157 DDYQQKRWSWGGSAMANSES-KTANKR-SASTEKLEQGTSALI-RQMPLSSAGLQNSVAK 213
Query: 284 N-----RSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGR 338
RS L+ +S+ L + T A + VT N Q P R T
Sbjct: 214 RKTDKERSSSLNRRDSN----LHSSTDKEQAERKPRVTGVTNYVMQYVTV-PLRKCTSDE 268
Query: 339 AGASLARGPQPDRTHPSAAVPVCPRS-ASASPLTPCSVTRSVHRCAPAGERGE------- 390
A + P + + + P++ SPL AP E
Sbjct: 269 LRAVM---------FPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSM 319
Query: 391 RRKPNAGGSPAPVRRRP-------EASPVQKKEKKDKERENEKEKSALARER---SLKKR 440
P AG AP + SPV + + E S A + +
Sbjct: 320 EASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPK 379
Query: 441 QSLPASPRARLSASTASELSPKSKAR-PSSPSTSWHRPASPCPSPGPGHTLPPKPP---- 495
S+ ASP A L A L + ++P S P P ++ P
Sbjct: 380 VSIVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESME 439
Query: 496 -SPRGTT-ASPKGRVRRKEEAKESPSAAGPEDKSQ---------SKRRASNEKE----SA 540
SP ASPK + EA A KS+ +K+R S+ E S+
Sbjct: 440 ASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSS 499
Query: 541 APASPAPSPAPSPTPAPPQKEQPPAETP--TDAAVLTSPPAPAPPV-------------- 584
+P + P+P T QK PP+ P + + TS P P+
Sbjct: 500 SPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVK 559
Query: 585 -------------------------TPSKPMAGTTDREEATRLLAEKRRQAREQREREEQ 619
+ +K AG + E AT++L E RR AREQRE+EE+
Sbjct: 560 KKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEE 619
Query: 620 ERRLQAERDKRMREEQ-LAREA---EARAEREAEARRREEQEAREKAQAEQEEQERLQKQ 675
ER+ + + + +++ + +A+EA +A + + +++ + ++K +QE+QE Q
Sbjct: 620 ERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEA-PLQ 678
Query: 676 KEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDS 733
K +A+ +++EEA++++ E E+ Q QER ER+KR+EEIMKRTRK++V+ +K + S
Sbjct: 679 KGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETS 736
Score = 50.8 bits (120), Expect = 5e-06
Identities = 47/199 (23%), Positives = 88/199 (44%), Gaps = 30/199 (15%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKR------MREEQLAREAEARAEREAE 649
RE R++A A+E+R+++ R + R + L + + R RE
Sbjct: 17 RELRARMVAAANEIAKERRKQDVVNRVATHSSNIRSTFKPVIDGSMLKNDIKQRLARERR 76
Query: 650 ARRREEQEAREKAQA-EQEEQERLQ--KQKEEAEARSREEAERQRLER----EKHFQQQE 702
+R +Q+A ++ Q E+E + +LQ KQ EE + + +E E++ R EK Q+ E
Sbjct: 77 EEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDE 136
Query: 703 QERQE---------RRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP-------- 745
++++ R+RL + ++ R S +SK AN +S E
Sbjct: 137 AQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSAL 196
Query: 746 VKAVEARSPGLQKEAVQKE 764
++ + S GLQ +++
Sbjct: 197 IRQMPLSSAGLQNSVAKRK 215
Score = 42.7 bits (99), Expect = 0.001
Identities = 63/262 (24%), Positives = 100/262 (38%), Gaps = 60/262 (22%)
Query: 8 ELGAGAPPAVVARTPPEP--RPSPEGDPSPPPPPMSALVP---------DTPPDTPPAMK 56
E APP V PE +PEG PP + + P ++ +P AM
Sbjct: 387 EASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMV 446
Query: 57 NATSSKQLPLEPESPSGQVGPRPAPPQEE-----------------------SPSSEAKS 93
A+ L E+ S + R AP + E S S E
Sbjct: 447 KASPKTSLEASMEA-SPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENAC 505
Query: 94 RGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA--------KER 145
P+P + R +++ PSP + + SP T K +H L+ K++
Sbjct: 506 GLPSPISTN----RQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKK 561
Query: 146 RE------ERAKYLAAKKAVWLEKEEKAKA------LREKQLQERRRRLEEQRLKAEQRR 193
+E R + L+ + ++ E K+ A K L E RR EQR K E+ R
Sbjct: 562 KETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEER 621
Query: 194 AALEERQRQKLEKNKERYEAAI 215
EE Q++ ++K+K+ + A+
Sbjct: 622 QR-EEMQQRVIKKSKDMAKEAV 642
Score = 37.0 bits (84), Expect = 0.076
Identities = 33/153 (21%), Positives = 67/153 (43%), Gaps = 15/153 (9%)
Query: 595 DREEATRL-----LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAE 649
++E T+L + E++R+ +E++E+EEQ RR+ AE + ++E + A R E
Sbjct: 93 EKERKTKLQYEKQMEERQRKLKERKEKEEQ-RRIAAEEKRHQKDEAQKEKFTAILYRTLE 151
Query: 650 ARRREEQEAREK--------AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQ 701
RR + +++ A +E + + E+ E + RQ Q
Sbjct: 152 RRRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLE-QGTSALIRQMPLSSAGLQNS 210
Query: 702 EQERQERRKRLEEIMKRTRKSEVSETKQKQDSK 734
+R+ ++R + +R S K++ + K
Sbjct: 211 VAKRKTDKERSSSLNRRDSNLHSSTDKEQAERK 243
Score = 36.2 bits (82), Expect = 0.13
Identities = 19/77 (24%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 689 RQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKA 748
+QRL RE+ ++E+ RQ+ + +++++ RK+++ KQ ++ + E +
Sbjct: 68 KQRLARER---REEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQRR 124
Query: 749 VEARSPGLQKEAVQKEE 765
+ A QK+ QKE+
Sbjct: 125 IAAEEKRHQKDEAQKEK 141
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 114 bits (284), Expect = 5e-25
Identities = 139/550 (25%), Positives = 232/550 (42%), Gaps = 121/550 (22%)
Query: 329 DP-GRGPTWGRAGASLARGPQPDRTHPSAAVPVCP-RSASASPLTPCSVTRSVHRCAPAG 386
DP G+G GR+ + L S A P P R +P+ P + + P G
Sbjct: 242 DPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFS------TPTG 295
Query: 387 ERGE----RRKPNAGGSPAPVRRRPEASPVQKKEKKDKE------RENEKEKSALAR--- 433
R + R P A SP+P + S V K+E + ++ +E +A R
Sbjct: 296 SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIIC 355
Query: 434 ----ERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP----STSWHRPASPCPSPG 485
ER L + E P + A P P + SW P
Sbjct: 356 HSYLERLLNVEVPQKVGSEQK---EPPEEAEPVAAAEPEVPENNGNNSW---------PH 403
Query: 486 PGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPAS- 544
+ P+P+ +SP+ ++EAK + A GP + QS RR + K++ +
Sbjct: 404 NDTEIANSTPNPKPAASSPETPSAGQQEAK-TDQADGPREPPQSARRKRSYKQAVSELDE 462
Query: 545 ----------PAPSPAPSPTPAPPQKEQPPAET-------------PTDA--AVLTS--- 576
P S PS +P P K P T PT A +V+ S
Sbjct: 463 EQHLEDEELQPPRSKTPS-SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
Query: 577 ---PPAPAPPVTPSKPMAGTTDREEATRLLAEK------RR----------------QAR 611
P P + + +EEA +L +K RR QAR
Sbjct: 522 RNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 581
Query: 612 EQREREEQERRLQAE-------------RDKRMREEQLAREAEARAEREAEARRREEQEA 658
E+ E+ ++E++ Q E +++R+ EE+ ++A A+ E EARR++E+EA
Sbjct: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 641
Query: 659 REKAQAEQEEQER-----LQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713
R +QEE+ER LQK+KEE + R R+ AE +RL ++ +++EQER+E+ +R +
Sbjct: 642 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
Query: 714 EIMKRTRKS---EVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
E ++ R+ +++E +++++ + A E KA+ + LQ+E +K++ +E
Sbjct: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK---KE 758
Query: 771 PQWSLPSKEL 780
Q L ++L
Sbjct: 759 EQQRLAERQL 768
Score = 88.2 bits (217), Expect = 3e-17
Identities = 97/398 (24%), Positives = 161/398 (40%), Gaps = 50/398 (12%)
Query: 395 NAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSAS 454
N+ +P P PE ++E K + + +E AR + K+ L
Sbjct: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
Query: 455 TASELSPKSKARPSSPSTSWHRPASPCPSP--------GPGHTLPPKPPSPRGTTAS--- 503
EL P PSSP PAS P L +PR S
Sbjct: 470 ---ELQPPRSKTPSSPC-----PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
Query: 504 --------PKGR-------VRRKEEAKESPSAAGPEDKSQSKRRASNEKES----AAPAS 544
PK + +RRKEEA++ EDK + ++E A
Sbjct: 522 RNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 581
Query: 545 PAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLA 604
+++ + T+ A A K A + EA R
Sbjct: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKA---KEERLAEEKAKKKAAAKKMEEVEARRKQE 638
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQ--LAREAEARAEREAEARRREEQEAREKA 662
E+ R+ R ++EE+ERR Q K+ EEQ L + AEA+ E + R EQE RE+
Sbjct: 639 EEARRLR-WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 697
Query: 663 QAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ----ERQERRKRLEEIMKR 718
+ EQE +E+ ++++E A E++RL+ E+ Q++E+ ++++ ++ LEE K+
Sbjct: 698 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 757
Query: 719 TRKSEVSE--TKQKQDSKEANANGSSPEPVKAVEARSP 754
+ ++E +++Q+ K A G+S V+ +SP
Sbjct: 758 EEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSP 795
Score = 60.5 bits (145), Expect = 6e-09
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 26/215 (12%)
Query: 18 VARTPPEPRPSPEGDPSPPPPPMSALVP--DTPPDTPPAMKNATSSKQLPLEPESPSGQV 75
+A + P P+P+ +P A D P + P + + S KQ E +
Sbjct: 408 IANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
Query: 76 GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP-----PRRSSQPSPTAVPASDSPPTKQ 130
PP+ ++PSS P P + R R R +PT+ P S K
Sbjct: 468 DEELQPPRSKTPSS------PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRS---VMKS 518
Query: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
+K+ KE+ +R + L KEE + R+K +++RRRLEE +LK E
Sbjct: 519 FIKRNTPLRMDPKEKERQRLENLR-------RKEEAEQLRRQKVEEDKRRRLEEVKLKRE 571
Query: 191 QR-RAALEERQR--QKLEKNKERYEAAIQRSVKKT 222
+R R L+ R+R Q E+ K++ E + +KT
Sbjct: 572 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 606
Score = 47.0 bits (110), Expect = 7e-05
Identities = 29/94 (30%), Positives = 57/94 (60%), Gaps = 5/94 (5%)
Query: 129 KQEVKKAGERHKLAKERREERAKY-LAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
++ ++KA E +LA++R +ER + ++ E+ E+ + +E+QL E+ RR E++RL
Sbjct: 668 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL 727
Query: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
+AE+ L+ER++ L KE+ + ++ KK
Sbjct: 728 QAERE---LQEREK-ALRLQKEQLQRELEEKKKK 757
Score = 47.0 bits (110), Expect = 7e-05
Identities = 31/94 (32%), Positives = 56/94 (59%), Gaps = 8/94 (8%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+++ ++ ER +ERR E+ + A ++ L++ EKA L+++QLQ R LEE++ K
Sbjct: 704 REQERREQERQLAEQERRREQERLQAERE---LQEREKALRLQKEQLQ---RELEEKKKK 757
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKT 222
EQ+R L ERQ Q+ ++ K + A +++ T
Sbjct: 758 EEQQR--LAERQLQEEQEKKAKEAAGASKALNVT 789
Score = 43.1 bits (100), Expect = 0.001
Identities = 51/228 (22%), Positives = 92/228 (40%), Gaps = 34/228 (14%)
Query: 23 PEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPP 82
P+ S + +P P++A P+ P + N+ + +P+ P+PA
Sbjct: 368 PQKVGSEQKEPPEEAEPVAAAEPEVPENNG---NNSWPHNDTEIANSTPN----PKPAAS 420
Query: 83 QEESPSS---EAKSRGPTPPAMGPRDARPPR-----------------RSSQPSPTAVPA 122
E+PS+ EAK+ P P+ AR R QP + P+
Sbjct: 421 SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS 480
Query: 123 SDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL 182
S P +K H + +R + +A ++V ++ LR ++ R+RL
Sbjct: 481 SPCPASKVVRPLRTFLHTV--QRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRL 538
Query: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E R K E E+ +RQK+E++K R ++ ++ ++ Q R
Sbjct: 539 ENLRRKEEA-----EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 581
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/127 (26%), Positives = 62/127 (48%), Gaps = 25/127 (19%)
Query: 129 KQEVKKAGERHKLAKERR--EERAKYLAAKKAV-----------------WLEKEEKAKA 169
+Q+ + E+ + AKE R EE+AK AA K + WL++EE+ +
Sbjct: 596 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 655
Query: 170 LRE------KQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223
+E ++ QER R+ E + AEQR E++R++ E+ ++ +R ++
Sbjct: 656 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 715
Query: 224 AEIRQQR 230
AE ++R
Sbjct: 716 AEQERRR 722
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 1/122 (0%)
Query: 104 RDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEK 163
++ R ++ A + +++ ++A L +E E R + L KK E+
Sbjct: 610 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE-EQ 668
Query: 164 EEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223
E KA K+L E+R + ++ + EQ R E R++++ E+ ++ E +R ++
Sbjct: 669 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
Query: 224 AE 225
AE
Sbjct: 729 AE 730
Score = 39.7 bits (91), Expect = 0.012
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 13/115 (11%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWL----EKEEKAKALREKQLQERRRRLEE 184
+QE ++ + L K++ EE+ + A +A L E+E + + RE++ +E+ RR +E
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
Query: 185 QR-----LKAEQRRAALE----ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+R L ++RR E ER+ Q+ EK + +QR +++ + QQR
Sbjct: 708 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 762
Score = 38.9 bits (89), Expect = 0.020
Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 3/104 (2%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRR---LEEQ 185
KQ +K + + ++ +EER AKK +K E+ +A R+++ + RR R EE+
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 652
Query: 186 RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+ ++ +E ++++L K E A QR ++ E R+Q
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 696
Score = 35.4 bits (80), Expect = 0.22
Identities = 96/452 (21%), Positives = 143/452 (31%), Gaps = 99/452 (21%)
Query: 404 RRRPEASPVQKKEKKDKER--ENEKEKSALARERSLKKRQSLP---------------AS 446
R++ S VQ + + R K +S+ R L+ + S+ +
Sbjct: 66 RKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVT 125
Query: 447 PRARLSASTASELSPKSKARPSSPSTSWHRP----------------------------- 477
A +A+ L+ S P SP+ +P
Sbjct: 126 RAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQ 185
Query: 478 ---ASPCP---SPGPGHTLPPKP---PSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQ 528
P P SP P P P+ + K + R E S A P+D
Sbjct: 186 LMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKG 245
Query: 529 SKRRASNEKESAAPASPAPSPAPSPT-PAPPQKEQPPA-------ETPTDAAVLTSPPAP 580
A +P P SP P P +E+ A TPT + S
Sbjct: 246 QGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRT-DSQSVR 304
Query: 581 APPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREA 640
P+ PS P + ++LA+K +Q E RR K+ EE A
Sbjct: 305 HSPIAPSSP---------SPQVLAQKYSLVAKQ---ESVVRRASRRLAKKTAEEP---AA 349
Query: 641 EARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQ 700
R + R E +K +EQ+E EEAE + E E +
Sbjct: 350 SGRIICHSYLERLLNVEVPQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSWPH 403
Query: 701 QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEA 760
+ E K S + + +Q++K A+G P A RS K+A
Sbjct: 404 NDTEIANSTPN----PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRS---YKQA 456
Query: 761 VQK-------EEPIPQEPQWSLPSKELPASLV 785
V + E+ Q P+ PS PAS V
Sbjct: 457 VSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
Score = 33.1 bits (74), Expect = 1.1
Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 10/114 (8%)
Query: 666 QEEQERL--QKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
QEE ER+ ++ +E E + +++ R ++ + Q++ R R+RL +++R S+
Sbjct: 38 QEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR--RKSRSSQ 95
Query: 724 VSETK-QKQDSKEANA-----NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771
+S + + +DS E A NGS V A + P P+ P
Sbjct: 96 LSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESP 149
Score = 31.6 bits (70), Expect = 3.2
Identities = 42/162 (25%), Positives = 58/162 (35%), Gaps = 34/162 (20%)
Query: 21 TPPEPRP-SPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLE-----PESPSGQ 74
T P PR SP P+ P S +P + ++ P A + + + P+ P GQ
Sbjct: 189 TEPLPRTLSPT--PASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQ 246
Query: 75 -----------------VGPRPAPPQEESPSSEAKSRGPTP-----PAMGPRDARPPRRS 112
GPR +P +SP E P P D++ R S
Sbjct: 247 GVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHS 306
Query: 113 ----SQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERA 150
S PSP + S KQE +LAK+ EE A
Sbjct: 307 PIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPA 348
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 110 bits (275), Expect = 5e-24
Identities = 137/554 (24%), Positives = 232/554 (41%), Gaps = 125/554 (22%)
Query: 329 DP-GRGPTWGRAGASLARGPQPDRTHPSAAVPVCP-RSASASPLTPCSVTRSVHRCAPAG 386
DP G+G GR+ + L S A P P R +P+ P + + P G
Sbjct: 242 DPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFS------TPTG 295
Query: 387 ERGE----RRKPNAGGSPAPVRRRPEASPVQKKEKKDKE------RENEKEKSALAR--- 433
R + R P A SP+P + S V K+E + ++ +E +A R
Sbjct: 296 SRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIIC 355
Query: 434 ----ERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP----STSWHRPASPCPSPG 485
ER L + E P + A P P + SW P
Sbjct: 356 HSYLERLLNVEVPQKVGSEQK---EPPEEAEPVAAAEPEVPENNGNNSW---------PH 403
Query: 486 PGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPAS- 544
+ P+P+ +SP+ ++EAK + A GP + QS RR + K++ +
Sbjct: 404 NDTEIANSTPNPKPAASSPETPSAGQQEAK-TDQADGPREPPQSARRKRSYKQAVSELDE 462
Query: 545 ----------PAPSPAPSPTPAPPQKEQPPAET-----PTDAAVLTSPPAPAPPV----- 584
P S PS +P P K P T + ++T AP +
Sbjct: 463 EQHLEDEELQPPRSKTPS-SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
Query: 585 --TPSKP-------------MAGTTDREEATRLLAEK------RR--------------- 608
TP + + +EEA +L +K RR
Sbjct: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 581
Query: 609 -QAREQREREEQERRLQAE-------------RDKRMREEQLAREAEARAEREAEARRRE 654
QARE+ E+ ++E++ Q E +++R+ EE+ ++A A+ E EARR++
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQ 641
Query: 655 EQEAREKAQAEQEEQER-----LQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERR 709
E+EAR +QEE+ER LQK+KEE + R R+ AE +RL ++ +++EQER+E+
Sbjct: 642 EEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 701
Query: 710 KRLEEIMKRTRKS---EVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEP 766
+R +E ++ R+ +++E +++++ + A E KA+ + LQ+E +K++
Sbjct: 702 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK- 760
Query: 767 IPQEPQWSLPSKEL 780
+E Q L ++L
Sbjct: 761 --KEEQQRLAERQL 772
Score = 85.9 bits (211), Expect = 1e-16
Identities = 97/402 (24%), Positives = 160/402 (39%), Gaps = 54/402 (13%)
Query: 395 NAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSAS 454
N+ +P P PE ++E K + + +E AR + K+ L
Sbjct: 410 NSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDE 469
Query: 455 TASELSPKSKARPSSPSTSWHRPASPCPSP--------GPGHTLPPKPPSPRGTTAS--- 503
EL P PSSP PAS P L +PR S
Sbjct: 470 ---ELQPPRSKTPSSPC-----PASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
Query: 504 --------PK-----------GRVRRKEEAKESPSAAGPEDKSQSKRRASNEKES----A 540
PK +RRKEEA++ EDK + ++E
Sbjct: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV 581
Query: 541 APASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEAT 600
A +++ + T+ A A K A + EA
Sbjct: 582 LQARERVEQMKEEKKKQIEQKFAQIDEKTEKA---KEERLAEEKAKKKAAAKKMEEVEAR 638
Query: 601 RLLAEKRRQAREQREREEQERRLQAERDKRMREEQ--LAREAEARAEREAEARRREEQEA 658
R E+ R+ R ++EE+ERR Q K+ EEQ L + AEA+ E + R EQE
Sbjct: 639 RKQEEEARRLR-WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Query: 659 REKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ----ERQERRKRLEE 714
RE+ + EQE +E+ ++++E A E++RL+ E+ Q++E+ ++++ ++ LEE
Sbjct: 698 REQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 757
Query: 715 IMKRTRKSEVSE--TKQKQDSKEANANGSSPEPVKAVEARSP 754
K+ + ++E +++Q+ K A G+S V+ +SP
Sbjct: 758 KKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSP 799
Score = 55.8 bits (133), Expect = 2e-07
Identities = 59/225 (26%), Positives = 94/225 (41%), Gaps = 42/225 (18%)
Query: 18 VARTPPEPRPSPEGDPSPPPPPMSALVP--DTPPDTPPAMKNATSSKQLPLEPESPSGQV 75
+A + P P+P+ +P A D P + P + + S KQ E +
Sbjct: 408 IANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLE 467
Query: 76 GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP-----PRRSSQPSPTAVPAS------- 123
PP+ ++PSS P P + R R R +PT+ P S
Sbjct: 468 DEELQPPRSKTPSS------PCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIK 521
Query: 124 DSPPTKQEVKKA---GERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR 180
+ P + + K + ER +L RR+E A+ L R+K +++RR
Sbjct: 522 RNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLR----------------RQKVEEDKRR 565
Query: 181 RLEEQRLKAEQR-RAALEERQR--QKLEKNKERYEAAIQRSVKKT 222
RLEE +LK E+R R L+ R+R Q E+ K++ E + +KT
Sbjct: 566 RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Score = 47.0 bits (110), Expect = 7e-05
Identities = 29/94 (30%), Positives = 57/94 (60%), Gaps = 5/94 (5%)
Query: 129 KQEVKKAGERHKLAKERREERAKY-LAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
++ ++KA E +LA++R +ER + ++ E+ E+ + +E+QL E+ RR E++RL
Sbjct: 672 QERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL 731
Query: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
+AE+ L+ER++ L KE+ + ++ KK
Sbjct: 732 QAERE---LQEREK-ALRLQKEQLQRELEEKKKK 761
Score = 47.0 bits (110), Expect = 7e-05
Identities = 31/94 (32%), Positives = 56/94 (59%), Gaps = 8/94 (8%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+++ ++ ER +ERR E+ + A ++ L++ EKA L+++QLQ R LEE++ K
Sbjct: 708 REQERREQERQLAEQERRREQERLQAERE---LQEREKALRLQKEQLQ---RELEEKKKK 761
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKT 222
EQ+R L ERQ Q+ ++ K + A +++ T
Sbjct: 762 EEQQR--LAERQLQEEQEKKAKEAAGASKALNVT 793
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/127 (26%), Positives = 62/127 (48%), Gaps = 25/127 (19%)
Query: 129 KQEVKKAGERHKLAKERR--EERAKYLAAKKAV-----------------WLEKEEKAKA 169
+Q+ + E+ + AKE R EE+AK AA K + WL++EE+ +
Sbjct: 600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERR 659
Query: 170 LRE------KQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223
+E ++ QER R+ E + AEQR E++R++ E+ ++ +R ++
Sbjct: 660 HQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQL 719
Query: 224 AEIRQQR 230
AE ++R
Sbjct: 720 AEQERRR 726
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/122 (22%), Positives = 57/122 (46%), Gaps = 1/122 (0%)
Query: 104 RDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEK 163
++ R ++ A + +++ ++A L +E E R + L KK E+
Sbjct: 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE-EQ 672
Query: 164 EEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTW 223
E KA K+L E+R + ++ + EQ R E R++++ E+ ++ E +R ++
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Query: 224 AE 225
AE
Sbjct: 733 AE 734
Score = 39.7 bits (91), Expect = 0.012
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 13/115 (11%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWL----EKEEKAKALREKQLQERRRRLEE 184
+QE ++ + L K++ EE+ + A +A L E+E + + RE++ +E+ RR +E
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
Query: 185 QR-----LKAEQRRAALE----ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+R L ++RR E ER+ Q+ EK + +QR +++ + QQR
Sbjct: 712 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
Score = 38.9 bits (89), Expect = 0.020
Identities = 29/116 (25%), Positives = 59/116 (50%), Gaps = 15/116 (12%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAK--------------ALREKQ 174
++ ++K + + ++ +EE+ K + K A EK EKAK A + ++
Sbjct: 575 EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEE 634
Query: 175 LQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVK-KTWAEIRQQ 229
++ RR++ EE R ++ E R ++ L+K KE + ++++ + K AE R+Q
Sbjct: 635 VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Score = 38.9 bits (89), Expect = 0.020
Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 3/104 (2%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRR---LEEQ 185
KQ +K + + ++ +EER AKK +K E+ +A R+++ + RR R EE+
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEE 656
Query: 186 RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+ ++ +E ++++L K E A QR ++ E R+Q
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 700
Score = 35.4 bits (80), Expect = 0.22
Identities = 96/452 (21%), Positives = 143/452 (31%), Gaps = 99/452 (21%)
Query: 404 RRRPEASPVQKKEKKDKER--ENEKEKSALARERSLKKRQSLP---------------AS 446
R++ S VQ + + R K +S+ R L+ + S+ +
Sbjct: 66 RKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVT 125
Query: 447 PRARLSASTASELSPKSKARPSSPSTSWHRP----------------------------- 477
A +A+ L+ S P SP+ +P
Sbjct: 126 RAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQ 185
Query: 478 ---ASPCP---SPGPGHTLPPKP---PSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQ 528
P P SP P P P+ + K + R E S A P+D
Sbjct: 186 LMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKG 245
Query: 529 SKRRASNEKESAAPASPAPSPAPSPT-PAPPQKEQPPA-------ETPTDAAVLTSPPAP 580
A +P P SP P P +E+ A TPT + S
Sbjct: 246 QGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRT-DSQSVR 304
Query: 581 APPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREA 640
P+ PS P + ++LA+K +Q E RR K+ EE A
Sbjct: 305 HSPIAPSSP---------SPQVLAQKYSLVAKQ---ESVVRRASRRLAKKTAEEP---AA 349
Query: 641 EARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQ 700
R + R E +K +EQ+E EEAE + E E +
Sbjct: 350 SGRIICHSYLERLLNVEVPQKVGSEQKE------PPEEAEPVAAAEPEVPENNGNNSWPH 403
Query: 701 QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEA 760
+ E K S + + +Q++K A+G P A RS K+A
Sbjct: 404 NDTEIANSTPN----PKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRS---YKQA 456
Query: 761 VQK-------EEPIPQEPQWSLPSKELPASLV 785
V + E+ Q P+ PS PAS V
Sbjct: 457 VSELDEEQHLEDEELQPPRSKTPSSPCPASKV 488
Score = 33.1 bits (74), Expect = 1.1
Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 10/114 (8%)
Query: 666 QEEQERL--QKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
QEE ER+ ++ +E E + +++ R ++ + Q++ R R+RL +++R S+
Sbjct: 38 QEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR--RKSRSSQ 95
Query: 724 VSETK-QKQDSKEANA-----NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771
+S + + +DS E A NGS V A + P P+ P
Sbjct: 96 LSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESP 149
Score = 31.6 bits (70), Expect = 3.2
Identities = 42/162 (25%), Positives = 58/162 (35%), Gaps = 34/162 (20%)
Query: 21 TPPEPRP-SPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLE-----PESPSGQ 74
T P PR SP P+ P S +P + ++ P A + + + P+ P GQ
Sbjct: 189 TEPLPRTLSPT--PASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQ 246
Query: 75 -----------------VGPRPAPPQEESPSSEAKSRGPTP-----PAMGPRDARPPRRS 112
GPR +P +SP E P P D++ R S
Sbjct: 247 GVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHS 306
Query: 113 ----SQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERA 150
S PSP + S KQE +LAK+ EE A
Sbjct: 307 PIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPA 348
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 107 bits (267), Expect = 5e-23
Identities = 137/664 (20%), Positives = 266/664 (40%), Gaps = 83/664 (12%)
Query: 172 EKQLQERRRRLEEQRLKAEQRRAALE--ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
++++ E RR+L+ + + E ++ + ERQR +LE + A+ Q ++++ AE+R
Sbjct: 315 QEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNT 374
Query: 230 RWSWAGALHH---------------SSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSS 274
+W A L ++ G C + +P + + K S S+
Sbjct: 375 KWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVST 434
Query: 275 ATLWNSPSRNRSLQLSAWESSIVDRLM--TPTLSFLARSRSAVTLPRNGRDQGRGCDPGR 332
S + + ++ S E+ IV+ T + G+++ G +
Sbjct: 435 HIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE--- 491
Query: 333 GPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERR 392
A G + + P A P + SP+ + + + A + E+ E +
Sbjct: 492 ---------EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAE---AKSPEKEEAK 539
Query: 393 KPNAGGSP----APVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPR 448
P SP +P + ++ P K +K++ + + KS + K+ PA +
Sbjct: 540 SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
Query: 449 ARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHT-------LPPKPPSPRGTT 501
+ A + + KS A SP + + SP + P K SP
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEE 659
Query: 502 A-SP-KGRVRRKEEAKESPSAAGP---EDKSQSKRRASNEKESAAP---ASPAPSPAPSP 553
A SP K + K EAK A P E KS K ++ ++E+ +P SP A SP
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719
Query: 554 TPA---------PPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEA---TR 601
A P+K + P + + P A + P A T +EEA
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779
Query: 602 LLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE------- 654
EK + ++ + ++ + + D + E+++ ++ E ++ + E + +E
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP 839
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKH--FQQQEQERQERRKRL 712
++ EKA A + +E+ +KEEA ++EA + ++E +K ++ ++ + E +K
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEA---PKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE 896
Query: 713 EEIMKRT---RKSEVSETKQKQDSK---EANANGSSPEPVKAVEARSPGLQKEAVQKEEP 766
E K+ K ++ + K+D+K + P+ KA E P +KEA +++
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKD 956
Query: 767 IPQE 770
+E
Sbjct: 957 TKEE 960
Score = 89.4 bits (220), Expect = 1e-17
Identities = 110/458 (24%), Positives = 195/458 (42%), Gaps = 64/458 (13%)
Query: 408 EASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARP 467
E + KE++ KE E +E+ A E K SP A +AS E K
Sbjct: 472 EEEEKEAKEEEGKEEEGGEEEEAEGGEEETK-------SPPAEEAASPEKEAKSPVKEEA 524
Query: 468 SSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPE-DK 526
SP+ + SP + P K SP KEEAK P A PE ++
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKS-PEKAKSPA------------KEEAKSPPEAKSPEKEE 571
Query: 527 SQSKRRASNEKESAAPA-----SPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPA 581
++S + +++ +PA SPA + +P +P ++E A++P +A A +
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE---AKSPAEAKSPVKEEAKS 628
Query: 582 PPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAE 641
P S A + +EEA ++ E+ + E+E E+ K +AE
Sbjct: 629 PAEVKSPEKAKSPTKEEA---------KSPEKAKSPEKEEAKSPEKAKS------PVKAE 673
Query: 642 ARAEREAEARRREEQEAREKAQAEQEEQERLQKQ-----KEEA----EARSREEAERQRL 692
A++ +A++ + E ++ EKA++ +E+ + ++ KEEA +A+S + E +
Sbjct: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 693 EREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKE------ANANGSSPEPV 746
E+ K ++E + E+ K E+ KS ++T K++++ A E V
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793
Query: 747 KAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK--ELPASLVNGLQPLPAHQENGFST--N 802
K+ E L+++A E+ IP++ + P K E P + P A +E +T
Sbjct: 794 KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT 853
Query: 803 GPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSPQVTEV 840
D P+ P + E K+ V+ P+ ++V
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEE-KKEPAVEKPKESKV 890
Score = 83.6 bits (205), Expect = 7e-16
Identities = 94/390 (24%), Positives = 161/390 (41%), Gaps = 30/390 (7%)
Query: 399 SPAPVRRRPEASPVQKKEKKDKERENEKEKS-ALARERSLKKRQSLPASPRARLSASTAS 457
SPA V+ +A K+E K E+ EK A + E++ ++ SP S A
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Query: 458 ELSP-KSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRR--KEEA 514
SP K+K+ + S + SP P K SP A + + KEEA
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS---PEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 515 KESPSAAGPE-----DKSQSKRRASNEKESAAPASPAPSPAPSPTP---APPQKEQPPAE 566
K A PE D + + ++E+ +PA P A SP P+K + P +
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 567 TPTDAAVLTSP---PAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRL 623
A P +P KP +E + E++ A + E ++ ++
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQ--EVKVKEPPKKAEEEKAPATPKTEEKKDSKKE 862
Query: 624 QA---ERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQ-----KQ 675
+A E K EE+ E E + EA++ E ++ ++ E+E +++ K
Sbjct: 863 EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKP 922
Query: 676 KEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
KE+ E +E + + E K +++E E++ EE K+ + +E K K+D K
Sbjct: 923 KEKTEVAKKEPDDAKAKEPSKPAEKKE-AAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981
Query: 736 ANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
+ S P+ KA ++ S QK++ E+
Sbjct: 982 LSKEPSKPKAEKAEKSSSTD-QKDSKPPEK 1010
Score = 83.2 bits (204), Expect = 9e-16
Identities = 97/409 (23%), Positives = 168/409 (41%), Gaps = 24/409 (5%)
Query: 387 ERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS 446
E GE + G + P A EK+ K E+ KS + K+ PA
Sbjct: 487 EGGEEEEAEGGEEET---KSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 447 PRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPP--SPRGTTASP 504
++ A + ++ KS SP + + SP + P K SP +
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS-PAKEEAKSPAEAKSPE 602
Query: 505 KGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPA-PPQKEQP 563
K + KEEAK SP+ A K ++K A + A SP A SP A P+KE+
Sbjct: 603 KAKSPVKEEAK-SPAEAKSPVKEEAKSPAEVKSPEKA-KSPTKEEAKSPEKAKSPEKEE- 659
Query: 564 PAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRL 623
A++P A A +P S A E+A + E+ + + + ++E +
Sbjct: 660 -AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK- 717
Query: 624 QAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQA-EQEEQERLQKQKEEAEAR 682
E+ K +E+ +A++ + EA+ E+ ++ EKA+ + + E KEEA +
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 683 SREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSS 742
+ + E+ + ++ + E+ + ++ + K K E ++ K++ K
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Query: 743 PEPVKAVEARSPGLQK----------EAVQKEEPIPQEPQWSLPSKELP 781
P P KA E ++P K EA +KE P P+ + P+ E P
Sbjct: 838 P-PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
Score = 72.8 bits (177), Expect = 1e-12
Identities = 113/586 (19%), Positives = 222/586 (37%), Gaps = 71/586 (12%)
Query: 2 ESGPRAELGAG-----APPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMK 56
E G E G +PPA A +P + SP + + P A P+ PA
Sbjct: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA--EAKSPEKEEAKSPAEV 544
Query: 57 NATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPS 116
+ + P + E+ S PP+ +SP E +++ P P A+ P + S
Sbjct: 545 KSPEKAKSPAKEEAKS--------PPEAKSPEKE-EAKSPAE-VKSPEKAKSPAKEEAKS 594
Query: 117 PTAV--PASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQ 174
P P P K+E K E KE + A+ + +KA K+ E +
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA-------KSPTKEEAK 647
Query: 175 LQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWA 234
E+ + E++ K+ ++ + + + + EK K +A +S +K + ++++ S
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE-AKSPEKAKSPVKEEAKSPE 706
Query: 235 GA---LHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSA 291
A + + + + S A K + + S A SP + ++L + +
Sbjct: 707 KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA---KSPEKAKTLDVKS 763
Query: 292 WESS--IVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQP 349
E+ + +P F +++S V +++ + + + P A A P+
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPV------KEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 350 DRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEA 409
+ P+ ++ APA + E +K ++ AP + EA
Sbjct: 818 EEVKSPVKEEEKPQEVKVKE----PPKKAEEEKAPATPKTEEKK-DSKKEEAP---KKEA 869
Query: 410 SPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPR-ARLSASTASELSPKSKARPS 468
+ +EKK+ E KE A++ + ++ +P + A + PK K +
Sbjct: 870 PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA 929
Query: 469 SPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQ 528
P P P+ + A+P+ + ++E+AK+ PE+K +
Sbjct: 930 K------------KEPDDAKAKEPSKPAEK-KEAAPEKKDTKEEKAKK------PEEKPK 970
Query: 529 SKRRASNEKE--SAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAA 572
++ +A + + S P+ P A + + +PP + D A
Sbjct: 971 TEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKA 1016
Score = 72.4 bits (176), Expect = 2e-12
Identities = 126/615 (20%), Positives = 228/615 (37%), Gaps = 91/615 (14%)
Query: 83 QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA 142
+EE E ++ G G + + P SP S P K+E K E
Sbjct: 484 KEEEGGEEEEAEG------GEEETKSPPAEEAASPEKEAKS---PVKEEAKSPAEAKSPE 534
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQ 202
KE + A+ + +KA KEE AK+ E + E+ EE + AE ++ ++
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEE-AKSPPEAKSPEK----EEAKSPAE-----VKSPEKA 584
Query: 203 KLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHV 262
K +E A +S +K + ++++ S A A SP + + S V + K
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA---KSPVKEEAKSPAEVKSPEKAKSP 641
Query: 263 DSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGR 322
K K+ SP + + +S + +P +++S V +
Sbjct: 642 TKEEAKSPEKA-----KSPEKEEAKSPEKAKSPVKAEAKSP-----EKAKSPV------K 685
Query: 323 DQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRC 382
+ + + + P A+ P+ ++ P P A +P
Sbjct: 686 AEAKSPEKAKSPV-----KEEAKSPEKAKS-PVKEEAKSPEKAK----SPVKEEAKTPEK 735
Query: 383 APAGERGERRKPNAGGSPAPVR----RRPEA-SPVQKKEKKDKERENEKEKSALARERSL 437
A + + E + P SP + + PEA +P +++ + ++ EK KS + E
Sbjct: 736 AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKS 795
Query: 438 KKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSP 497
++ P A+ A E K SP +P PPK
Sbjct: 796 PEKAKSPLKEDAK-----APEKEIPKKEEVKSPVKEEEKPQEVKVKE------PPKKAEE 844
Query: 498 RGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNE--KESAAPASPAPSPAPSPTP 555
A+PK ++ + +E+P P+ K + K+ + E KES A + P
Sbjct: 845 EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904
Query: 556 APPQKEQPPAETPTDA------AVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ 609
P ++ E DA V P A PSKP AEK+
Sbjct: 905 TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP--------------AEKKEA 950
Query: 610 AREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQ 669
A E+++ +E++ + E+ K E A+E + +E + E +A + + +Q++
Sbjct: 951 APEKKDTKEEKAKKPEEKPK---TEAKAKEDDKTLSKEPSKPKAE--KAEKSSSTDQKDS 1005
Query: 670 ERLQKQKEEAEARSR 684
+ +K E+ A+ +
Sbjct: 1006 KPPEKATEDKAAKGK 1020
Score = 70.9 bits (172), Expect = 5e-12
Identities = 122/599 (20%), Positives = 229/599 (38%), Gaps = 48/599 (8%)
Query: 143 KERREERAKYL--AAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQ 200
K + EE+ K + + K+ V +E++ + + E+ +E + +E+ K E+ E
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 201 RQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGAL-----HHSSPGHKTSGSRCSVSA 255
++ K+ EAA K+ + ++++ S A A SP S + A
Sbjct: 497 GEEETKSPPAEEAASPE--KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 256 VNLPKHVDSIIN--KRLSKSSATLWNSPSRNRSLQL----SAWESSIVDRLMTPTLSFL- 308
K + K +KS A + SP + +S S E+ ++ +P
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEV-KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 309 --ARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSAS 366
A ++S V + + + + PT A+ P+ ++ P P A
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPT-----KEEAKSPEKAKS-PEKEEAKSPEKAK 667
Query: 367 ASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEK 426
+ P A + + E + P SP V+ ++ K K++ + EK
Sbjct: 668 S----PVKAEAKSPEKAKSPVKAEAKSPEKAKSP--VKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 427 EKSALARERSLKKRQSLPA-----SPRARLSASTASELSPKSKARPSSPSTSWHRPASPC 481
KS + E ++ P SP S A L KS + PA
Sbjct: 722 AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF 781
Query: 482 PSPGPGHTL-----PPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDKSQSKRRASN 535
P P K SP A +P+ + +KEE K S E+K Q +
Sbjct: 782 PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK---SPVKEEEKPQEVKVKEP 838
Query: 536 EKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTD 595
K++ +PA +P ++E P E P PA P SK A +
Sbjct: 839 PKKAEEEKAPA-TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP-KESKVEAKKEE 896
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
E+ ++ ++ + +E+ + + + E K+ ++ A+E AE++ EA ++
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK-EAAPEKK 955
Query: 656 QEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
EKA+ +E+ + K KE+ + S+E ++ + + EK +++ + K E+
Sbjct: 956 DTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 57.0 bits (136), Expect = 7e-08
Identities = 64/260 (24%), Positives = 107/260 (41%), Gaps = 16/260 (6%)
Query: 578 PAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLA 637
P P P P T + ++ + + +E EEQ Q + EE+ A
Sbjct: 419 PFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEA 478
Query: 638 REAEARAE---REAEARRREEQ----EAREKAQAEQEEQERLQKQ-KEEAEARSREEAER 689
+E E + E E EA EE+ A E A E+E + ++++ K AEA+S E+ E
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 690 QRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAV 749
+ K ++ + +E K E ++ + E +++ + S E + + E
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPE--AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA 596
Query: 750 EARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQP----LPAHQENGFSTNGPS 805
EA+SP K V++E P E + P KE S P P +E S
Sbjct: 597 EAKSPEKAKSPVKEEAKSPAEAK--SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654
Query: 806 GDKSLSRTPETLLPFAEAEA 825
+K +++PE +AEA
Sbjct: 655 PEKEEAKSPEKAKSPVKAEA 674
Score = 45.4 bits (106), Expect = 2e-04
Identities = 62/244 (25%), Positives = 103/244 (42%), Gaps = 28/244 (11%)
Query: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT 569
RK A + SAAG S R S SA+P+ + A S T + P
Sbjct: 30 RKGGAGGTRSAAGSSSGFHSWTRTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMV 89
Query: 570 DAAVLTSPPAPAPPVTPSKPMAGTTDR----EEATRLL-----AEKRRQAREQREREEQE 620
AV TS + AG D+ E R L A +++QA E E
Sbjct: 90 --AVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYE 147
Query: 621 RRLQAERDKRMR----EEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQK 676
R ++ R +R QL E E E A R+R + EAR++ +AE +
Sbjct: 148 REVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAAR------- 200
Query: 677 EEAEARSREEAERQRLEREKHFQQQEQE----RQERRKRLEEIMKRTRKSEVSETKQKQD 732
A AR +EAE R++ +K Q ++E R+ ++ + E++ + + S ++ + + +
Sbjct: 201 --ALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAE 258
Query: 733 SKEA 736
+++A
Sbjct: 259 TRDA 262
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/125 (27%), Positives = 57/125 (45%), Gaps = 9/125 (7%)
Query: 608 RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQE 667
R+ R Q E + LQ+E R+R ++L+ A+ + A + E E R + QA
Sbjct: 272 REIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSA-QEEITEYRRQLQARTT 330
Query: 668 EQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSET 727
E E L+ K + ERQR E E Q QE ++L+ ++ T+ ++
Sbjct: 331 ELEALKSTK--------DSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQL 382
Query: 728 KQKQD 732
++ QD
Sbjct: 383 REYQD 387
Score = 38.5 bits (88), Expect = 0.026
Identities = 49/222 (22%), Positives = 82/222 (36%), Gaps = 42/222 (18%)
Query: 11 AGAPPAVVARTPPEPRPSPEGDPSP---PPPPMSALVPDTP--------PDTPPAMKNAT 59
A +P A+ P + P E SP P V + P P TP +
Sbjct: 799 AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD 858
Query: 60 SSKQLPLEPESPSGQVGPRPAPPQEESPSS---------EAKSRGPTPPAMGP------R 104
S K+ + E+P +V + P E+ S E K + PTP P
Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
Query: 105 DARPPRRS---------------SQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREER 149
DA+P ++ S+P+ A + TK+E K E + + +E
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKED 978
Query: 150 AKYLAAKKA-VWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
K L+ + + EK EK+ + +K + + E++ K +
Sbjct: 979 DKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 98.2 bits (243), Expect = 3e-20
Identities = 140/587 (23%), Positives = 214/587 (36%), Gaps = 61/587 (10%)
Query: 20 RTPPEPRPSPE-GDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPR 78
++ P PSPE P PP + L+ + +P + S++ P+ P S + R
Sbjct: 345 KSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQE-PVNPPSEASPTRDR 403
Query: 79 PAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPA-------SDSPPTKQE 131
+PP+ ++ S +PP+ P SS SP PA S SP +K
Sbjct: 404 -SPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNR 462
Query: 132 VKKAGER---HKLAKERREERAKYLAAKKAVWLEKEEKAKA--LREKQLQERRRRLEEQ- 185
+R H RR R++ A K K R + Q RR R ++
Sbjct: 463 SHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRW 522
Query: 186 -RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGH 244
R ++ QRR QR +++ RS ++ G H SP
Sbjct: 523 GRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARR-------------GRSHSRSPA- 568
Query: 245 KTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPT 304
T G S + + +R S+S +P+R RS R TP
Sbjct: 569 -TRGRSRSRTPARRGRSRSRTPARRRSRS-----RTPTRRRS------------RSRTPA 610
Query: 305 LSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRS 364
+RSR+ R R R P R+G S +R P S RS
Sbjct: 611 RRGRSRSRTPARRRSRTRSPVRRRSRSRSPA-RRSGRSRSRTPARRGRSRSRTPARRGRS 669
Query: 365 ASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAP--VRRRPEASPVQKKEKKDKER 422
S +P +RS R R R P G S + VRR S ++ +
Sbjct: 670 RSRTPARRSGRSRS--RTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSS 727
Query: 423 ENEKEKSALARERSLKKRQSLPASPRARLSASTASELS-PKSKARPSSPSTSWHRPASPC 481
K KS ++ RS + S P ++R+S+ + LS P+SKA+ +SPC
Sbjct: 728 SERKNKSRTSQRRS--RSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPC 785
Query: 482 PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAA 541
P PP+ R ++ PK + R S S+ P+ KS++ R S+ S
Sbjct: 786 PKQKS--QTPPR--RSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPH 841
Query: 542 PASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSK 588
P + +P + PQ + + +SP TPS+
Sbjct: 842 PKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSR 888
Score = 92.4 bits (228), Expect = 2e-18
Identities = 131/582 (22%), Positives = 210/582 (36%), Gaps = 52/582 (8%)
Query: 3 SGPRAELGAGAPPAVVARTPPE-PRPSPEGDPSPP--PPPMSALVPDTPPDTPPAMKNAT 59
+ PRA+ G+ + P A P PR S G S P P + ++ P+ PP + A
Sbjct: 1610 AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTAR 1669
Query: 60 SSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTA 119
+ EP++ S PP+ S S + R AR RRS S +
Sbjct: 1670 RGSRSSPEPKTKSR------TPPRRRSSRSSPELT---------RKARLSRRSRSASSSP 1714
Query: 120 VPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERR 179
S +PP + K R R + ++ + + ++ + + + LQ R
Sbjct: 1715 ETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSR 1774
Query: 180 RRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239
R ++ + +RR Q + + R + + R R H
Sbjct: 1775 SRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTR------------RRRGGSGYHS 1822
Query: 240 SSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDR 299
SP + S S + + + S++S W SR+R+ + S R
Sbjct: 1823 RSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKR-SRSRASPATHRRS----R 1877
Query: 300 LMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAG-----ASLARGPQPDRTHP 354
TP +S RSRS T P + R R + RA S +R P R
Sbjct: 1878 SRTPLIS-RRRSRSR-TSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRS 1935
Query: 355 SAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRR-RPEASPVQ 413
+ P R S S P + RS R P RR+ + SP RR R SPV
Sbjct: 1936 RSRTPT-TRRRSRSRTPPVTRRRSRSRTPPV----TRRRSRSRTSPITRRRSRSRTSPVT 1990
Query: 414 KKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTS 473
++ + + + +S ++R P R + + + L P+ ++R SP
Sbjct: 1991 RRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAI 2050
Query: 474 WHRPASPCPSPGPG-HTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRR 532
R S P G +L PP+ R +AS R + +P A S++
Sbjct: 2051 RRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSR---SATPPATRNHSGSRTPPV 2107
Query: 533 ASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVL 574
A N + + P+ SP P P +P + T +VL
Sbjct: 2108 ALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVL 2149
Score = 89.4 bits (220), Expect = 1e-17
Identities = 97/438 (22%), Positives = 163/438 (37%), Gaps = 66/438 (15%)
Query: 344 ARGPQPDRTHPSAAVPVCPRSASASPLTPCSVT-----RSVHRCAPAGERGERRKPNAGG 398
A+ P P+ P + V S S +P R +P ER + K
Sbjct: 160 AKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHR 219
Query: 399 SPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASE 458
S + ++R SP K ++K K+++ ++ +S +S + +S A + S +
Sbjct: 220 SESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRS 279
Query: 459 LSPKSKARPS-----SPS-TSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKE 512
S +K + SPS S R P PG T +P SP T P K+
Sbjct: 280 RSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKD 339
Query: 513 EAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSP--------APSPTPAPPQKEQP- 563
+ K+ SA P S E+ S P PAP+P +P P P ++P
Sbjct: 340 KDKKEKSATRPS--------PSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPV 391
Query: 564 -----------------PAETPTDAAVLTSPPAPAP----------PVTPSKPMAGTTDR 596
P + P ++ +SPP+P P P +P A + R
Sbjct: 392 NPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHR 451
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAE---REAEARRR 653
E ++ ++ R R +R++ + R R R A+ +R+ + +R R
Sbjct: 452 EISSSPTSKNRSHGRAKRDKSHS--HTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSR 509
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713
Q R ++ Q + + + RSR +R R ++ Q++ + R RR R
Sbjct: 510 SPQWRRSRS-----AQRWGRSRSPQRRGRSR-SPQRPGWSRSRNTQRRGRSRSARRGRSH 563
Query: 714 EIMKRTRKSEVSETKQKQ 731
TR S T ++
Sbjct: 564 SRSPATRGRSRSRTPARR 581
Score = 89.0 bits (219), Expect = 2e-17
Identities = 200/943 (21%), Positives = 326/943 (34%), Gaps = 145/943 (15%)
Query: 2 ESGPR-AELGAGAP-PAVVARTPPEPRPSPEGDPSPPPPPMSALVPD------------- 46
E+ PR + G+ +P P V A+TPP P S P P +LV
Sbjct: 982 ETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKS 1041
Query: 47 -TPP----------------DTPPAMKNATSSKQL-PLEPESPS----GQVGPRPAPPQE 84
TPP T P ++ TSS ++ ESPS Q P+ +
Sbjct: 1042 STPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRS 1101
Query: 85 ESPSSEAKSRGPTPPAMGPRDARPPRRSS--------QPSPTAVPASDSPPT--KQEVKK 134
SP +E SR P G A P +S Q ++ P DS + ++
Sbjct: 1102 SSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLET 1161
Query: 135 AGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKA----- 189
A + K+A +E+ +K + + + ++ R +R A
Sbjct: 1162 AESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPE 1221
Query: 190 --EQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKT- 246
EQ A Q ++L + E+ E + + +E+++ S SSP +
Sbjct: 1222 TKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTS----NFESSPEVEER 1277
Query: 247 ---------SGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSL---------- 287
S S+ S+ AV +P S S L NSP R S
Sbjct: 1278 PAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSG 1337
Query: 288 -----QLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGAS 342
+ + S + + L P L+ L S ++ R G +AG S
Sbjct: 1338 PLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMS 1397
Query: 343 ------------LARGPQPDRTHPSAA------VPVCP----RSASASPLTPCSVTRSVH 380
+ R P +R+ +++ +P P RS S+ L S T S H
Sbjct: 1398 SNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRH 1457
Query: 381 RCAPA--GERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALA--RERS 436
+ + G + R P+ G S P+A P + + E L RERS
Sbjct: 1458 SLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERS 1517
Query: 437 LKK----RQSLPASPRARLSASTAS-ELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLP 491
+ ++++ +P + S S +S EL K A P S S P S + P
Sbjct: 1518 GSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKT-----RTP 1572
Query: 492 PKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAP 551
+ S G+ SP+ + + + S S + PE K K RA+ +S + +SP P AP
Sbjct: 1573 LRQRSRSGS--SPEVDSKSRLSPRRSRSGSSPEVKD--KPRAAPRAQSGSDSSPEPK-AP 1627
Query: 552 SPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAR 611
+P P + + + S + P P K + + R R
Sbjct: 1628 APRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPR 1687
Query: 612 EQREREEQERRLQAERDKRMREEQLAREAEAR----------------AEREAEARRREE 655
+ R E +A +R R + E +R AE+ +RRR
Sbjct: 1688 RRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRS 1747
Query: 656 QEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEI 715
+ + + K + +RSR E+ R R + Q RR+R
Sbjct: 1748 ASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSR 1807
Query: 716 MKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSL 775
+ TR+ + ++ +S + P +K + + P P + S
Sbjct: 1808 SRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSR 1867
Query: 776 PSKELPAS--LVNGLQPLPAHQENGFSTNGPSGDKSLSRTPET 816
S PA+ PL + + + T+ S +S SRT T
Sbjct: 1868 AS---PATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVT 1907
Score = 81.3 bits (199), Expect = 4e-15
Identities = 193/889 (21%), Positives = 298/889 (33%), Gaps = 144/889 (16%)
Query: 12 GAPPAVVARTP-------PEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL 64
G P +A TP P SP D SPP P + +PP+ + S+
Sbjct: 375 GGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHA 434
Query: 65 PLEPESPSGQVGPRPAPPQEE----SPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV 120
PESP P PAP SP+S+ +S G P RR + A
Sbjct: 435 SSSPESPK----PAPAPGSHREISSSPTSKNRSHGRAKRDKS-HSHTPSRRMGRSRSPAT 489
Query: 121 PASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKAL----REKQLQ 176
++ K+ R + + RR A+ ++ ++ R + Q
Sbjct: 490 AKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQ 549
Query: 177 ERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEA---AIQRSVKKTWAEIRQQRWSW 233
R R +R ++ R A R R + + R + A +RS +T R + +
Sbjct: 550 RRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTP 609
Query: 234 A--GALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRN-----RS 286
A G +P + S +R V + + + S++ A S SR RS
Sbjct: 610 ARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRS 669
Query: 287 LQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGR-----GCDPGRGPTW-GRAG 340
+ S R TP +RSR+ PR GR + R G R P GR+G
Sbjct: 670 RSRTPARRSGRSRSRTPARRGRSRSRT----PRRGRSRSRSLVRRGRSHSRTPQRRGRSG 725
Query: 341 ASLAR---------------GPQPDRTHPSAAVP---VCPRSASASPLT---------PC 373
+S R P+ ++ S+ PRS + S L+ PC
Sbjct: 726 SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPC 785
Query: 374 SVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALAR 433
+S + P R +P A P R R +SP K++ K R++ S +
Sbjct: 786 PKQKS--QTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPK 843
Query: 434 ERS-LKKRQSLPASPRARLSASTASELS-------PKSKAR-PSSPSTSWHRP----ASP 480
+S RQ SP+A + T S P+ K+R PS S S P +S
Sbjct: 844 VKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSST 903
Query: 481 CPSPGPGHTLPPKP------------------PSP----------RGTTASPKGRVRRKE 512
P P + P+P PSP R + SP V +
Sbjct: 904 PPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRL 963
Query: 513 EAKESPSAAGPEDKSQSKRRASNEKESA---------APASPAPSPAPSPTPAPPQKEQP 563
+ S S + D + S A P PS + S +P P +K +
Sbjct: 964 LPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKD 1023
Query: 564 ------PAETPTDAAVLTS-PPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQRER 616
P A V +S PP + S + G + R + E R+
Sbjct: 1024 SLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHR----SDTSSPEVRQS 1079
Query: 617 EEQERRLQAERD---KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQ 673
+ LQ++ K R + E + R E + EQ R Q
Sbjct: 1080 HSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQ 1139
Query: 674 KQKEE-AEARSREEAERQRLE----REKHFQQQEQE------RQERRKRLEEIMKRTRKS 722
S + RLE +EK +++ RQ+ + + R S
Sbjct: 1140 SDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESS 1199
Query: 723 EVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771
V + + +E + GSSPE + A Q E + + +EP
Sbjct: 1200 LVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEP 1248
Score = 79.7 bits (195), Expect = 1e-14
Identities = 90/373 (24%), Positives = 145/373 (38%), Gaps = 26/373 (6%)
Query: 289 LSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQ 348
LSA+E V +P L ARSR+ + P R P G+A + P
Sbjct: 2387 LSAYER--VSGRTSPPLLDRARSRTPPSAPSQSRMTSERA-PSPSSRMGQAPSQSLLPPA 2443
Query: 349 PDRTHPSAAVPVCPRSASA---SPLTPCSVTRSVHRCA------PAGERGERRKPNAGGS 399
D+ P + VP S + TP + ++S+ A AG+ A G
Sbjct: 2444 QDQ--PRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGV 2501
Query: 400 PAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASEL 459
P P AS ++ + KE+ + + S S +S + S+S +S
Sbjct: 2502 PHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS 2561
Query: 460 SPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPS 519
+ + P P + R SP P+P +PP P +P R RR + S S
Sbjct: 2562 DSEGSSLPVQPEVALKRVPSPTPAPKEA-VREGRPPEP-----TPAKRKRRSSSSSSSSS 2615
Query: 520 AAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPA 579
++ S S +S+ S++ +S + S + SP+PA P P P A+ PP
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG----PQALPKPASPKKPPPG 2671
Query: 580 PAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLARE 639
+P KP+ D + E+RR + + R++Q +ER R + +R
Sbjct: 2672 ERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSS--SSERGSRRGQRGDSRS 2729
Query: 640 AEARAEREAEARR 652
+ RE + R
Sbjct: 2730 PSHKRRRETPSPR 2742
Score = 79.3 bits (194), Expect = 1e-14
Identities = 153/728 (21%), Positives = 260/728 (35%), Gaps = 123/728 (16%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALE 197
R + AK+ E K + + + K ++K+ ++R RR E + E+++++ +
Sbjct: 156 RAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKK 215
Query: 198 ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVN 257
++ R + E K ++ + +S +K+ + R++ S ++P K+ + S SA
Sbjct: 216 KKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRS-------TTPAPKSRRAHRSTSA-- 266
Query: 258 LPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTL 317
S+++ S SR+RS +++ R +P + +
Sbjct: 267 --------------DSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSE 312
Query: 318 PRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPV-CPRSASASPLTPCSVT 376
P Q P T + +S D+ SA P P +S P P
Sbjct: 313 PGTTSTQR----PSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPP---- 364
Query: 377 RSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERS 436
AP ER GGSP P+ P + +E N +++ R+RS
Sbjct: 365 ------APTPLLAERH----GGSPQPLATTPLS----------QEPVNPPSEASPTRDRS 404
Query: 437 LKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPS 496
P SP +L S++SE SP S P S H +SP SP P P P S
Sbjct: 405 P------PKSPE-KLPQSSSSESSPPS---PQPTKVSRHASSSP-ESPKPA----PAPGS 449
Query: 497 PRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPA 556
R ++SP + R AK S S + R S A A S + +PT
Sbjct: 450 HREISSSPTSKNRSHGRAKRDKS------HSHTPSRRMGRSRSPATAKRGRSRSRTPTKR 503
Query: 557 PPQKEQPP-------------AETPTDAAVLTSPPAPAPPVTPSKPMAGTT--------- 594
+ + P + +P SP P + + G +
Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSH 563
Query: 595 DREEATRLLAEKRRQAREQREREE----QERRLQAERDKRMREEQLAREAEARAEREAEA 650
R ATR + R AR R R + R + +R R AR +R+ A
Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR 623
Query: 651 RRREEQEAREKAQAEQEEQE--RLQKQKEEAEARSREEAERQR--------LEREKHFQQ 700
R R R ++++ + R + + RSR +R R +
Sbjct: 624 RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRS 683
Query: 701 QEQERQER---------RKRLEEIMKRTRK-SEVSETKQKQDSKEANANGSSPEPVKAVE 750
+ R+ R R R +++R R S + + + S N S ++
Sbjct: 684 RTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRS 743
Query: 751 ARSPGLQKEAV-QKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQEN---GFSTNGPSG 806
SP ++K + + P+ S+ ++G P P + S +G S
Sbjct: 744 NSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQ 803
Query: 807 DKSLSRTP 814
K+ SRTP
Sbjct: 804 PKAKSRTP 811
Score = 78.2 bits (191), Expect = 3e-14
Identities = 117/543 (21%), Positives = 200/543 (36%), Gaps = 71/543 (13%)
Query: 280 SPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRA 339
+PSR RS S+ E D L T S +RS S+ L R G P
Sbjct: 1413 TPSRERSSSASSPEMK--DGLPR-TPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDI 1469
Query: 340 GASLARG-PQPDRTHPSAAVPVCPRSASASPLTP-----------------CSVTRSVHR 381
+ +RG + D + A+P PR S SP +P SV +
Sbjct: 1470 PRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVA 1529
Query: 382 CAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQ 441
P G+R GS + +P ASP ++ E K ++ L R+RS +
Sbjct: 1530 RTPLGQRSR------SGSSQELDVKPSASPQERSESDSSPDSKAKTRTPL-RQRS-RSGS 1581
Query: 442 SLPASPRARLS-----ASTASELSPKSKARPSSPSTSWHRPASPCPSPGP-------GHT 489
S ++RLS + ++ E+ K +A P + S S P P+P G +
Sbjct: 1582 SPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSS 1641
Query: 490 LPPKPPSPRG---TTASPKGRVRRKEEAKESPSAAGPEDKSQS--KRRASNEKE------ 538
+ PSP G T +SP+ + + + S S+ P+ KS++ +RR+S
Sbjct: 1642 SKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKA 1701
Query: 539 --SAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDR 596
S S + SP P + P +P A S +P R
Sbjct: 1702 RLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGR 1761
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
+ + +R ++R +RE+ RR RD+ + +R + R RRR
Sbjct: 1762 SPSPKPRGLQRSRSRSRREKTRTTRR----RDRSGSSQSTSRRRQRSRSRSRVTRRRRGG 1817
Query: 657 EAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLERE-----KHFQQQEQERQERRKR 711
++E R ++ +R+ + ++ R K + + RR R
Sbjct: 1818 SGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSR 1877
Query: 712 -----LEEIMKRTRKSEVSETKQKQD---SKEANANGSSPEPVKAVEARSPGLQKEAVQK 763
+ R+R S VS + + ++ + + +SP + +R+P + + +
Sbjct: 1878 SRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRS 1937
Query: 764 EEP 766
P
Sbjct: 1938 RTP 1940
Score = 68.6 bits (166), Expect = 2e-11
Identities = 178/848 (20%), Positives = 281/848 (33%), Gaps = 115/848 (13%)
Query: 18 VARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGP 77
V RTP R S P + D P TP + SS L +PS
Sbjct: 1410 VPRTPSRERSSSASSPE---------MKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLS 1460
Query: 78 RPAPPQEESPSSEAKSR-----GPTPPAMGPRDARPPRRS-SQP---SPTAVPASDSPPT 128
+P ++ P + ++ R P P A+ P+ RP RS S P + P + +
Sbjct: 1461 GSSPGMKDIPRTPSRGRSECDSSPEPKAL-PQTPRPRSRSPSSPELNNKCLTPQRERSGS 1519
Query: 129 KQEV-KKAGERHKLAKERREERAKYLAAKKAVWLEKEEK------AKALREKQLQERRRR 181
+ V +K R L + R ++ L K + ++ + +KA L++R R
Sbjct: 1520 ESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRS 1579
Query: 182 LEEQRLKAEQRRAALEERQRQKLE-KNKERYEAAIQRS-----VKKTWAEIRQQRWSWAG 235
+ ++ R + R E K+K R Q K A R S +G
Sbjct: 1580 GSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSG 1639
Query: 236 ALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESS 295
+ S S + PK + R S T +P R RS
Sbjct: 1640 SSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRS--------- 1690
Query: 296 IVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPS 355
SRS+ L R R R P + +R P R PS
Sbjct: 1691 ---------------SRSSPELTRKARLSRRSRSASSSP------ETRSRTPPRHRRSPS 1729
Query: 356 AAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKK 415
+ P P +RS R A + G SP+P R + S + +
Sbjct: 1730 VSSP-----------EPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRS--RSR 1776
Query: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWH 475
+++K R + + + + + ++RQ + R S +S AR S TS
Sbjct: 1777 SRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSR 1836
Query: 476 RPASPCPSPGPGH-----TLPPKPPSPRGTTASPKGRVRRKEEA-----KESPSAAGPED 525
R +P P P + ASP R + + S S P
Sbjct: 1837 RRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVS 1896
Query: 526 KSQSKRRAS-NEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPV 584
+ +S+ R S + S + ASP P + + + TPT S PPV
Sbjct: 1897 RRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRS---RTPPV 1953
Query: 585 TPSKPMAGT---TDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAE 641
T + + T T R +R RR++R R RR ++ R +R +
Sbjct: 1954 TRRRSRSRTPPVTRRRSRSRTSPITRRRSR-SRTSPVTRRRSRSRTSPVTRRRSRSRTSP 2012
Query: 642 ARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEA-RSREEAERQRLEREKHFQQ 700
R +R R R ++++ R + + A R R + R R K
Sbjct: 2013 VTRRR---SRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLT 2069
Query: 701 QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSK--EANANGS--------SPEPVKAVE 750
+ RR R+R + T+ S+ N S S P
Sbjct: 2070 RSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDR 2129
Query: 751 ARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQP-LPAHQENGFSTNGPSGDKS 809
RSPG+ EP+ ++ S+++G P +P HQ N +
Sbjct: 2130 CRSPGML-------EPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIA 2182
Query: 810 LSRTPETL 817
L+ T +L
Sbjct: 2183 LALTAISL 2190
Score = 66.6 bits (161), Expect = 9e-11
Identities = 169/833 (20%), Positives = 276/833 (33%), Gaps = 78/833 (9%)
Query: 23 PEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSG------QVG 76
P+ R P+P PP +LV ++ P K K+ S S +
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKS 212
Query: 77 PRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAG 136
+ + ES S + K R PTP + R ++ +R S T P S A
Sbjct: 213 SKKKKHRSESESKKRKHRSPTPKS--KRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSAS 270
Query: 137 ERHKLAKERREERAK----YLAAKK-AVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQ 191
R AK LA + + + + A + +R +Q
Sbjct: 271 SSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQ 330
Query: 192 RRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRC 251
+ E++ + K EK+ R + +RS T E + A H + +
Sbjct: 331 PSSPYEDKDKDKKEKSATRPSPSPERS--STGPE--PPAPTPLLAERHGGSPQPLATTPL 386
Query: 252 SVSAVNLPKHVDSIINKRLSKSSATLWNSP--SRNRSLQLSAWESSIVDRLMTPTLSFLA 309
S VN P S++S T SP S + Q S+ ESS T +
Sbjct: 387 SQEPVNPP-----------SEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHAS 435
Query: 310 RS-RSAVTLPRNGRDQGRGCDP-GRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASA 367
S S P G + P + + GRA + P R + P + +
Sbjct: 436 SSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRS 495
Query: 368 SPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKE 427
TP R R R R G S +P RR SP + + + +
Sbjct: 496 RSRTP--TKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRR-- 551
Query: 428 KSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPG 487
R RS ++ +S SP R ++R +P+ R S P+
Sbjct: 552 ----GRSRSARRGRSHSRSPATR------------GRSRSRTPARR-GRSRSRTPARRRS 594
Query: 488 HTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGP---EDKSQSKRRASNEKESAAPAS 544
+ P R T + +GR R + A+ P +S+S R S S PA
Sbjct: 595 RSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPAR 654
Query: 545 PAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAG-TTDREEATRLL 603
S + +P + + PA + T PA P G + R R
Sbjct: 655 RGRSRSRTPARRGRSRSRTPARRSGRSRSRT--PARRGRSRSRTPRRGRSRSRSLVRRGR 712
Query: 604 AEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQ 663
+ R R R ER+ ++ +R E + R + R R R KA+
Sbjct: 713 SHSRTPQRRGRSGSSSERKNKSRTSQRRSRSN--SSPEMKKSRISSRRSRSLSSPRSKAK 770
Query: 664 AEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
+ + L + +S+ R R + + + R R+ S
Sbjct: 771 SRLSLRRSLSGSSPCPKQKSQTPPRRSR---------SGSSQPKAKSRTPPRRSRSSSSP 821
Query: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPAS 783
+ K K S++++++ SSP P V++ +P Q PQ + S+ +
Sbjct: 822 PPKQKSKTPSRQSHSS-SSPHP--KVKSGTPPRQGSITS-----PQANEQSVTPQRRSCF 873
Query: 784 LVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSPQ 836
+ L + + S +G S + S TP P + K + SP+
Sbjct: 874 ESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPR 926
Score = 53.1 bits (126), Expect = 1e-06
Identities = 90/431 (20%), Positives = 141/431 (32%), Gaps = 124/431 (28%)
Query: 344 ARGPQPDRTH--PSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPA 401
A P RT P++A V PRSA A+ + +R+ APA R P G+
Sbjct: 2321 ANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANL 2380
Query: 402 PVRRRP---------EASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLS 452
R P SP + + + +S + ER+ SP +R+
Sbjct: 2381 TSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERA--------PSPSSRMG 2432
Query: 453 ASTASELSPKSKARPSSPSTSWHRPASPC------------------------------- 481
+ + L P ++ +P SP S S C
Sbjct: 2433 QAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNG 2492
Query: 482 ----PSPGPGHTLPPKPPS------PRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSK- 530
P+PG H+ +PP+ P A + RR + S S++ S S
Sbjct: 2493 MLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSS 2552
Query: 531 -----RRASNEKESAAPASP--APSPAPSPTPAPPQ---KEQPPAETP------------ 568
+S+ + S+ P P A PSPTPAP + + +PP TP
Sbjct: 2553 SSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSS 2612
Query: 569 ---------------------------TDAAVLTSPPAPA--------PPVTPSKPMAGT 593
+ ++ +S P+PA P +P KP G
Sbjct: 2613 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGE 2672
Query: 594 TDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER-----EA 648
R + R + R +R + RR + R ++ + R +R +
Sbjct: 2673 R-RSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPS 2731
Query: 649 EARRREEQEAR 659
RRRE R
Sbjct: 2732 HKRRRETPSPR 2742
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/238 (24%), Positives = 92/238 (38%), Gaps = 30/238 (12%)
Query: 354 PSAAVPVCP----RSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGS---------- 399
PSA + P RS+S+S + S + S + + G + G S
Sbjct: 2518 PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALK 2577
Query: 400 ------PAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSA 453
PAP E P + K K R + S+ + S S +S + S+
Sbjct: 2578 RVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2637
Query: 454 STASELSPKSKARPSSPS-TSWHRPASP-CPSPGPGHTLPPKPP--SPRGTTASPKGRVR 509
S++S S S P+ P + +PASP P PG + P+ P S R + + V
Sbjct: 2638 SSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVE 2697
Query: 510 RKEEAKESPSAAGPEDKSQSKRRAS---NEKESAAPASPAPSPAPSPTPAPPQKEQPP 564
R+ + SP + + +S S R S +S +P+ PSP P + + P
Sbjct: 2698 RR---RPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/189 (23%), Positives = 68/189 (35%), Gaps = 45/189 (23%)
Query: 3 SGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMK------ 56
S + G+ + + + P +P + + PSP P P A+ PP+ PA +
Sbjct: 2550 SSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSS 2609
Query: 57 ------------------------------NATSSKQLPLEPESPSGQVGPRPAPPQEES 86
+++SS P P Q P+PA P ++
Sbjct: 2610 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP-KKP 2668
Query: 87 PSSEAKSRGPTPPAMGPRDARP--------PRRSSQPSPTAVPASDSPPTKQEVKKAGER 138
P E +SR P P RD+R R S QPSP +S S + ++ R
Sbjct: 2669 PPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSR 2728
Query: 139 HKLAKERRE 147
K RRE
Sbjct: 2729 SPSHKRRRE 2737
Score = 45.8 bits (107), Expect = 2e-04
Identities = 37/131 (28%), Positives = 52/131 (39%), Gaps = 11/131 (8%)
Query: 2 ESGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPD----TPPDTPPAMKN 57
++ PR + P +RTPP S S PPP + P + P +K+
Sbjct: 791 QTPPRRSRSGSSQPKAKSRTPPRRSRS----SSSPPPKQKSKTPSRQSHSSSSPHPKVKS 846
Query: 58 ATSSKQLPL-EPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPS 116
T +Q + P++ V P+ E SP E KSR TP + PPR S
Sbjct: 847 GTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSR--TPSRHSCSGSSPPRVKSSTP 904
Query: 117 PTAVPASDSPP 127
P P+ S P
Sbjct: 905 PRQSPSRSSSP 915
Score = 45.1 bits (105), Expect = 3e-04
Identities = 128/608 (21%), Positives = 207/608 (34%), Gaps = 71/608 (11%)
Query: 19 ARTPPEPRPSPEGDPSPPPPPMS------ALVPDTPPDTPPAMKNATSSKQLPLEPESPS 72
+RTPP R SP P S A + TP + + S+ P+
Sbjct: 1842 SRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSR 1901
Query: 73 GQVG-PRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQE 131
+ R SP S +SR TPP R RS P+ S +PP +
Sbjct: 1902 SRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRS-----RSRTPTTRRRSRSRTPPVTRR 1956
Query: 132 VKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQ 191
+ + + R R + +++ + R + RRR + +
Sbjct: 1957 -RSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTR 2015
Query: 192 RRA------ALEERQRQKL-----EKNKERYEAAIQR-SVKKTWAEIRQQRWSWAGALHH 239
RR+ A+ R R + ++++ R AI+R S +T R +R +L
Sbjct: 2016 RRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKR-----SLTR 2070
Query: 240 SSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDR 299
S P + + S S R + AT +S SR + L++ S R
Sbjct: 2071 SPPAIRRRSASGSSSD-----------RSRSATPPATRNHSGSRTPPVALNSSRMSCFSR 2119
Query: 300 -LMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGP--TWGRAGASLARGPQPD-RTHPS 355
M+PT L R RS L G R P +AG S+ GP P H
Sbjct: 2120 PSMSPTP--LDRCRSPGMLEPLGSS--------RTPMSVLQQAGGSMMDGPGPRIPDHQR 2169
Query: 356 AAVPVCPRSASASPLTPCSVTRSVHRCAPA-GERGERRKPNAGGSPAPV---RRRPEASP 411
+VP + S L +++ R P+ G + + +P P+ R P A+
Sbjct: 2170 TSVPE-NHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANL 2228
Query: 412 VQKKEKKDKERENEKEKSALARERSLKKRQSLP---------ASPRARLSASTASELSPK 462
+ N A ++ S ASPR ++ S + P+
Sbjct: 2229 ASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPR 2288
Query: 463 SKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAG 522
+ P+ PA+ G PP + ++ +P+ S A
Sbjct: 2289 TPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATA 2348
Query: 523 PEDKSQSKRRASNEKES--AAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAP 580
P + + S+ A+ S +A +PA S A +P P T +L +
Sbjct: 2349 PVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSR 2408
Query: 581 APPVTPSK 588
PP PS+
Sbjct: 2409 TPPSAPSQ 2416
Score = 43.9 bits (102), Expect = 6e-04
Identities = 77/365 (21%), Positives = 130/365 (35%), Gaps = 45/365 (12%)
Query: 483 SPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAP 542
+PG P + P+ T + ++ E + +A G D ++ +
Sbjct: 104 NPGGKEETPGQRPAVTETHQLAELNEKKNERLR---AAFGISDSYVDGSSFDPQRRAREA 160
Query: 543 ASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRL 602
PAP P P P +E + +PT P K G + R
Sbjct: 161 KQPAPEP---PKPYSLVRESSSSRSPT----------PKQKKKKKKKDRGRRSESSSPRR 207
Query: 603 LAEKRRQAREQREREE-QERRLQAERDKRMREEQLAREAEARAEREA-EARRREEQEARE 660
+K + ++ R E ++R+ ++ K R+ + + +R+ A ++RR + +
Sbjct: 208 ERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSAD 267
Query: 661 KAQAEQEEQERLQKQKEEAE-----ARSREEAERQRLEREKHFQQQEQERQERRKRLEEI 715
A + + R + + RS A +R E + F + +R E
Sbjct: 268 SASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETA 327
Query: 716 MKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSL 775
K + S E K K D KE +A SP P E S G P P P L
Sbjct: 328 TK--QPSSPYEDKDK-DKKEKSATRPSPSP----ERSSTG----------PEPPAPTPLL 370
Query: 776 PSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSP 835
+ + PL N S P+ D+S ++PE L + +E + SP
Sbjct: 371 AERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSE-----SSPPSP 425
Query: 836 QVTEV 840
Q T+V
Sbjct: 426 QPTKV 430
Score = 41.2 bits (95), Expect = 0.004
Identities = 47/201 (23%), Positives = 84/201 (41%), Gaps = 7/201 (3%)
Query: 586 PSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAE 645
P+ +GT + L RR R + EE+ RRL+A KR + L E + R E
Sbjct: 8 PTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVE 67
Query: 646 -REAEARRREEQEAREKAQAEQEEQE-RLQKQKEEAEARSREEAERQR-LEREKHFQQQE 702
R E E++ E+ Q +++ RL +++ +EE QR E H +
Sbjct: 68 LRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAEL 127
Query: 703 QERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAV----EARSPGLQK 758
E++ R R + + S Q++ + P+P V +RSP ++
Sbjct: 128 NEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQ 187
Query: 759 EAVQKEEPIPQEPQWSLPSKE 779
+ +K++ + + S P +E
Sbjct: 188 KKKKKKKDRGRRSESSSPRRE 208
Score = 40.8 bits (94), Expect = 0.005
Identities = 49/244 (20%), Positives = 89/244 (36%), Gaps = 11/244 (4%)
Query: 5 PRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL 64
P A GA P A+ A P + R S S S+ + + + + + L
Sbjct: 2509 PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL 2568
Query: 65 PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASD 124
P++PE +V P P P +E+ E + PTP R + SS S ++ +S
Sbjct: 2569 PVQPEVALKRV-PSPTPAPKEA-VREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSS 2626
Query: 125 SPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
S + + + AK +A+ K E++ + R+ ++
Sbjct: 2627 SSSSSSSSSSSSSSSSSSSSSSPSPAK--PGPQALPKPASPKKPPPGERRSRSPRKPIDS 2684
Query: 185 QR-------LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGAL 237
R E+RR + + R + + ER QR ++ + R++ +
Sbjct: 2685 LRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPM 2744
Query: 238 HHSS 241
H S
Sbjct: 2745 RHRS 2748
Score = 38.1 bits (87), Expect = 0.034
Identities = 27/104 (25%), Positives = 40/104 (38%), Gaps = 16/104 (15%)
Query: 19 ARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPR 78
A+ P+ P P PPP + P P D+ ++++ S P+E PS Q PR
Sbjct: 2652 AKPGPQALPKPASPKKPPPGERRSRSPRKPIDS---LRDSRSLSYSPVERRRPSPQPSPR 2708
Query: 79 PAPPQEE-------------SPSSEAKSRGPTPPAMGPRDARPP 109
SPS + + P+P M R +R P
Sbjct: 2709 DQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 35.0 bits (79), Expect = 0.29
Identities = 32/135 (23%), Positives = 50/135 (37%), Gaps = 7/135 (5%)
Query: 6 RAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLP 65
R +PP V + TPP PS P P + + + + + +S+ P
Sbjct: 888 RHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTP 947
Query: 66 LEPE--SPSGQVGPRPAPPQEESPSS--EAKSRGPTPPAM---GPRDARPPRRSSQPSPT 118
SP V R P S SS + K + TPP G P ++ P
Sbjct: 948 RRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGP 1007
Query: 119 AVPASDSPPTKQEVK 133
++ S SP +++ K
Sbjct: 1008 SLSGSKSPCPQEKSK 1022
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 97.8 bits (242), Expect = 4e-20
Identities = 97/382 (25%), Positives = 152/382 (39%), Gaps = 52/382 (13%)
Query: 400 PAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASEL 459
P P+ E SP +K KK+KE+E + +S R RS + ++ SP S
Sbjct: 250 PEPIPEPKEPSP-EKNSKKEKEKEKTRPRS---RSRSKSRSRTRSRSP---------SHT 296
Query: 460 SPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPK--PPSPRGTTASPKGRVRRKEEAKES 517
P+ + R S S S R SP P P PP+ PP PR + R RR+ A
Sbjct: 297 RPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSA--- 353
Query: 518 PSAAGPEDKSQSKRRASNEKESAAPASPAPSPAP--SPTPAPPQKEQPPAETPTDAAVLT 575
S +G S S R S K+ S P SP+ +PP++ P
Sbjct: 354 -SLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRP----------- 401
Query: 576 SPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQ 635
SPPA PP T P ++R +R+ R + + + + E+R + R+ +
Sbjct: 402 SPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVE 461
Query: 636 LAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLERE 695
L+ E + + A A +Q Q R Q Q+ +++ S +E +R +R
Sbjct: 462 LSESEEDKGGKMAAA-----------DSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKR- 509
Query: 696 KHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
H + E R+ R +R + S K+++++ SP P RSP
Sbjct: 510 SHVKNGEVGRRRRH-------SPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPS 562
Query: 756 LQKEAVQKEEPIPQEPQWSLPS 777
++ P P P+ PS
Sbjct: 563 PAPPPRRRRTPTP-PPRRRTPS 583
Score = 96.3 bits (238), Expect = 1e-19
Identities = 158/692 (22%), Positives = 237/692 (34%), Gaps = 129/692 (18%)
Query: 23 PEPRPSPEGDPSP---PPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVG--- 76
P RPSP PSP PP P P + SS L S S
Sbjct: 311 PRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSP 370
Query: 77 PRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDS--PPTKQEVKK 134
P+ P + SP + + P+ A PPRR +PSP A P + PT Q+ +
Sbjct: 371 PKKPPKRTSSPPRKTRRLSPS--------ASPPRRRHRPSPPATPPPKTRHSPTPQQSNR 422
Query: 135 AGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRA 194
R+ R + + K + K ++R E + R+
Sbjct: 423 T----------RKSRVSVSPGRTS--------GKVTKHKGTEKR----ESPSPAPKPRKV 460
Query: 195 ALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVS 254
L E + K K A+ QQR + SS +S S S
Sbjct: 461 ELSESEEDK--------------GGKMAAADSVQQRRQYRRQNQQSSSDSGSSSS----S 502
Query: 255 AVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSA 314
PK + N + + +SPSR+ S R R
Sbjct: 503 EDERPKR-SHVKNGEVGRRRR---HSPSRSASPS--------------------PRKRQK 538
Query: 315 VTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCS 374
T PR R + P PT R S A P+ RT PR + SP P
Sbjct: 539 ETSPRGRRRRS----PSPPPTRRRRSPSPAPPPRRRRTPTPP-----PRRRTPSP-PPRR 588
Query: 375 VTRSVHRCAPAGERGERRKP----NAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSA 430
+ S R +P +R P P P +RR SP K+ ++
Sbjct: 589 RSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPV 648
Query: 431 LARER-SLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHT 489
R SL + +SP S ST SP+ R S P P P T
Sbjct: 649 TKRRSPSLSSKHRKGSSP----SRSTREARSPQPNKRHS-----------PSPRPRAPQT 693
Query: 490 LPPKPPSPRGTTASPK------------GRVRRKEEAKESPSAAGPEDKSQSKRRASNEK 537
PP RG ++SP+ RV R E K+ AA P QS RR S+ +
Sbjct: 694 SSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASP--SPQSVRRVSSSR 751
Query: 538 ESAAPASPAPSPAPSPTPAPPQKEQPPAE-TPTDAAVLTSPPAPAPPVTPSKPMAGTTDR 596
+ PA P+P P+P Q + P +P P P+P + G +
Sbjct: 752 SVSGSPEPAAKKPPAP-PSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKK 810
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
++ + K+ + ++ ++ ++E+ + A + +A A+ E A ++
Sbjct: 811 KKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKK 870
Query: 657 EAREKAQAEQEEQERLQKQKEEAEARSREEAE 688
E +A ++ + L+K E RS +A+
Sbjct: 871 ETESEA---EDNLDDLEKHLREKALRSMRKAQ 899
Score = 85.1 bits (209), Expect = 2e-16
Identities = 155/732 (21%), Positives = 248/732 (33%), Gaps = 137/732 (18%)
Query: 163 KEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKT 222
++EK +++++ + +R EE+ E+R + R+R+ + R + ++R K++
Sbjct: 137 EQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRS 196
Query: 223 WAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPS 282
H SP H+T SR A + + + ++ + S
Sbjct: 197 ---------------HSRSPRHRTK-SRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATS 240
Query: 283 RNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRN-GRDQGRGCDPGRGPTWGRAGA 341
+ L++ E + +P + T PR+ R + R R P+ R
Sbjct: 241 TSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTR--- 297
Query: 342 SLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPA 401
P R H S RS S SP R +P RR+ P
Sbjct: 298 -------PRRRHRS-------RSRSYSPR---------RRPSPRRRPSPRRRTPPRRMPP 334
Query: 402 PVRRRPEASPVQKKEKKDKERENEKEKSALARERS----LKKRQSLPASPRARLSASTAS 457
P R R SPV+++ + S+ +R RS KR S P RLS S +
Sbjct: 335 PPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS- 393
Query: 458 ELSPKSKARPSSPSTSWHRPA-SPCP-----------SPGPGHT--------------LP 491
P+ + RPS P+T + SP P S PG T P
Sbjct: 394 --PPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESP 451
Query: 492 PKPPSPRGTTAS----PKG---------------RVRRKEEAKESPSAAGPEDKSQSKRR 532
P PR S KG R + ++ + +S S++ ED+ + KR
Sbjct: 452 SPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDE-RPKRS 510
Query: 533 ASNEKESAAPASPAPSPAPSPTPAPPQKE--------QPPAETPTDAAVLTSPPAPAPPV 584
E +PS + SP+P QKE + P+ PT P+PAPP
Sbjct: 511 HVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRR---RRSPSPAPP- 566
Query: 585 TPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARA 644
P + T T +RR +R +RR + R + RA
Sbjct: 567 -PRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRA 625
Query: 645 EREAEARRREEQEAREKAQAEQEEQER---LQKQKEEAEARSREEAERQRLEREKHFQQQ 701
+RR K ++ + R L + + + SR E + + K
Sbjct: 626 SPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPS 685
Query: 702 EQERQERRKRLEEIMKRTRKSEVSETKQKQDS-KEANANGSSPEPVKAVEARSPGLQK-- 758
+ R + ++R S + S + +PEP K +A SP Q
Sbjct: 686 PRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVR 745
Query: 759 ------------EAVQKEEPIPQEP--------QWS--LPSKELPASLVNGLQPLPAHQE 796
E K+ P P P WS +P K+ + + P + QE
Sbjct: 746 RVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQE 805
Query: 797 NGFSTNGPSGDK 808
G DK
Sbjct: 806 GGGKKKKKKKDK 817
Score = 75.1 bits (183), Expect = 3e-13
Identities = 149/731 (20%), Positives = 262/731 (35%), Gaps = 99/731 (13%)
Query: 92 KSRGPTP-----PAMGPR---DARPPR---RSSQPSPTAVPASDSP-----------PTK 129
KSR P+P P R +R PR +S PSP +P P+
Sbjct: 176 KSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSV 235
Query: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ---- 185
QE + K+ K K + +K EKE++ R + + R R +
Sbjct: 236 QEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSH 295
Query: 186 ---RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSV------KKTWAEIRQQRWSWAGA 236
R + R + R+R + R + +++ + +R++R S A
Sbjct: 296 TRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASL 355
Query: 237 LHHSSPGHKTSGSRCSVSAVNLPKHVDSIINK--RLSKSSATLWNSPSRNRSLQLSAWES 294
SS +S SR PK S K RLS S+ SP R R + S +
Sbjct: 356 SGSSS---SSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSA-----SPPRRRH-RPSPPAT 406
Query: 295 SIVDRLMTPTLSFLARSRSAVTLPRNGRDQG-----RGCDPGRGPTWG--RAGASLARGP 347
+PT R+R + GR G +G + P+ L+
Sbjct: 407 PPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESE 466
Query: 348 QPDRTHPSAAVPVCPR----------SASASPLTPCSVTRSVHRCAPAGERGERRK--PN 395
+ +AA V R S+ + + R GE G RR+ P+
Sbjct: 467 EDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPS 526
Query: 396 AGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSAST 455
SP+P +R+ E SP ++ + + +S ++R P PR R +
Sbjct: 527 RSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTP-PPRRRTPSPP 585
Query: 456 ASELSPKSKARPSSPSTSWHRPASP------CPSPGPGHTLPPKPPSPRGTTASPKGRVR 509
SP S R S P + P+ P P P P P PP R + SP + R
Sbjct: 586 PRRRSP-SPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQR 644
Query: 510 RKEEAK-ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETP 568
K SPS + K S R++ E SP P+ SP+P P + + P
Sbjct: 645 SSPVTKRRSPSLSSKHRKGSSPSRSTREAR-----SPQPNKRHSPSPRPRAPQTSSSPPP 699
Query: 569 TDAAVLTSP---PAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQA 625
+SP +P+P P + ++ T E ++ + + RR+ +
Sbjct: 700 VRRGASSSPQRRQSPSPSTRPIRRVSRT----------PEPKKIKKAASPSPQSVRRVSS 749
Query: 626 ERDKRMREEQLAREAEA---RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEAR 682
R E A++ A + ++ + +KA++ + +E +
Sbjct: 750 SRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGK 809
Query: 683 SREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSS 742
+++ + ++ +++K ++ ++ ++E+ T + + T + ++
Sbjct: 810 KKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPV----AA 865
Query: 743 PEPVKAVEARS 753
PEP K E+ +
Sbjct: 866 PEPKKETESEA 876
Score = 53.5 bits (127), Expect = 8e-07
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 21/163 (12%)
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
++E ++ Q EQE+ ++KQ E+ + R +EE E R +++E+ R RR++
Sbjct: 127 KKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSR-------EKRERSRSPRRRKSRS 179
Query: 715 IMKRTRKSEVSETKQKQDSKEA--NANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
R R S V +++ S+ SP P + ++P L + +V+ +EP QE
Sbjct: 180 PSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEAT 239
Query: 773 WSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPE 815
+ ++P +P+P +E PS +K+ + E
Sbjct: 240 STSDILKVPKP-----EPIPEPKE-------PSPEKNSKKEKE 270
Score = 52.8 bits (125), Expect = 1e-06
Identities = 47/161 (29%), Positives = 57/161 (35%), Gaps = 36/161 (22%)
Query: 2 ESGPRAELGAG-APPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP----------- 49
E+ PR +PP R P P P P +P PPP P PP
Sbjct: 539 ETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRR-TPSPPPRRRSPSPRRYS 597
Query: 50 --------DTPPAMKNATSSKQLPLEPESPS----GQVGPRPAPPQ-------EESPSSE 90
+PP + S P SPS +V P P Q SPS
Sbjct: 598 PPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLS 657
Query: 91 AKSRGPTPPAMGPRDARPP----RRSSQPSPTAVPASDSPP 127
+K R + P+ R+AR P R S P P A S SPP
Sbjct: 658 SKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPP 698
Score = 50.8 bits (120), Expect = 5e-06
Identities = 57/244 (23%), Positives = 91/244 (37%), Gaps = 34/244 (13%)
Query: 3 SGPRAELGAGAPPAVVARTPPEPRP-SPEGDPSPPPPPMSAL---------VPDTPP--- 49
S P P R P PRP +P+ SPPP A P T P
Sbjct: 664 SSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRR 723
Query: 50 ---------------DTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSR 94
+P +++ +SS+ + PE + + P+P Q +SPS+
Sbjct: 724 VSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPA 783
Query: 95 GPTPPAMGPRDA-RPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYL 153
P A P + PPR S Q K + K ++HK K+ ++E+A
Sbjct: 784 VPVKKAKSPTPSPSPPRNSDQEG----GGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAA 839
Query: 154 AAKKAVWLEKEEKA-KALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYE 212
AA AV A L +++ +E +AE LE+ R+K ++ + +
Sbjct: 840 AAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQ 899
Query: 213 AAIQ 216
+ Q
Sbjct: 900 VSPQ 903
Score = 45.8 bits (107), Expect = 2e-04
Identities = 35/131 (26%), Positives = 51/131 (38%), Gaps = 12/131 (9%)
Query: 14 PPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP---DTPPAMKNATSSKQLPLEPES 70
PP +PP P P+ SP PPP + PP +P + + S + S
Sbjct: 609 PPKRRTASPP---PPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSS 665
Query: 71 PSGQV----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPAS--D 124
PS P+P SP A +PP + + P+R PSP+ P
Sbjct: 666 PSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVS 725
Query: 125 SPPTKQEVKKA 135
P +++KKA
Sbjct: 726 RTPEPKKIKKA 736
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/243 (16%), Positives = 95/243 (39%), Gaps = 28/243 (11%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
+EE + E+ + A +++ E++++R + E++ + + +R R R RRR
Sbjct: 128 KEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSS 187
Query: 656 QEAREKAQAEQEEQERLQKQKEEAEARSREE-----------------------AERQRL 692
RE+ ++ K + + A ++E ++ ++
Sbjct: 188 PVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKV 247
Query: 693 EREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEAR 752
+ + + ++ E+ + E+ ++TR S +K + ++ + + + P +R
Sbjct: 248 PKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSR 307
Query: 753 SPGLQKEAVQKEEPIPQE--PQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSL 810
S ++ + P P+ P +P P P+ + + S +G S S
Sbjct: 308 SYSPRRRPSPRRRPSPRRRTPPRRMPP---PPRHRRSRSPVRRRRRSSASLSGSSSSSSS 364
Query: 811 SRT 813
SR+
Sbjct: 365 SRS 367
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/167 (17%), Positives = 68/167 (40%), Gaps = 8/167 (4%)
Query: 612 EQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQER 671
E ++ E ++R+++ E+ M+++ ++ + E+E+ +RE + + ++ R
Sbjct: 125 ELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRR 184
Query: 672 LQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQ 731
RS + R R + E++E+ L E + ++ V E
Sbjct: 185 RSSPVRRERKRSHSRSPRHRTKSRS--PSPAPEKKEKTPELPEPSVKVKEPSVQEATSTS 242
Query: 732 DSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
D + P+P E + P +K + +++E P+ SK
Sbjct: 243 DILKV------PKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSK 283
>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 96.3 bits (238), Expect = 1e-19
Identities = 98/364 (26%), Positives = 158/364 (43%), Gaps = 52/364 (14%)
Query: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPK--------SKARP 467
E++ K ++ E+ + RE K+R P SP A +A+ A+ +P S + P
Sbjct: 157 ERRAKLQQCRAERERIMREE--KRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLP 214
Query: 468 SSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDK 526
+SP+ R AS PSP T PP S G + S RR+E A S S A
Sbjct: 215 ASPAPRAARKAS--PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
Query: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT-----DAAVLTSPPAPA 581
S R A+ + P+ + S T P + P L+ P A
Sbjct: 273 SGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTA 332
Query: 582 P-------PVTPSKPMAGTTDREEATRLLAEKRRQ----------------------ARE 612
V + + G +R+ L R Q A++
Sbjct: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
Query: 613 QREREEQERRLQAERDKRMREEQL--AREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
+REREE+E++ E+ +R Q+ R R EREA RR+ + E E+ + E E++
Sbjct: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
Query: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQK 730
L + +E AE +RE+ R +L++E++ +Q+E+ QE R+R E+I +R R + KQ+
Sbjct: 453 GLLR-RERAERAAREDRLR-KLQQEQNLKQREEGLQEGRERAEQI-RRERAQRAARAKQR 509
Query: 731 QDSK 734
Q+ +
Sbjct: 510 QEGQ 513
Score = 69.7 bits (169), Expect = 1e-11
Identities = 100/390 (25%), Positives = 158/390 (40%), Gaps = 45/390 (11%)
Query: 368 SPLTPCSVTRSVHRCAPAGERGERRKPNAGG---SPAP-VRRRPEASPVQKKEKKDKERE 423
+PL+P + + A A G ++ SPAP R+ SP + +
Sbjct: 182 TPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGS 241
Query: 424 NEKEKSALARERSLKKRQSLPASPRARLSASTASELS-----PKSKARPSSP----STSW 474
KS S ++ +L + A S+ + L P++ AR S P S++
Sbjct: 242 RTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTT 301
Query: 475 HRPASPC-----PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED-KSQ 528
+ P P P G +L SP+ TA R+ R+ A+ D K
Sbjct: 302 NAPGRPSALTLVPITGRSFSLGDLSHSPQ--TAQHVERIVRQVRAERGLRGVPERDRKIA 359
Query: 529 SKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAET-PTDAAVLTSPPAPAPPVTPS 587
+ A +++E A + K++ E A+ A A V
Sbjct: 360 ALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEER 419
Query: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD---KRMREEQLAREAEARA 644
+ G +RE A R+ + Q ER E+ RR AER +R R E+ ARE R
Sbjct: 420 RGRRGREEREAA--------RRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
Query: 645 -EREAEARRREE--QEAREKA-QAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKH-- 697
++E ++REE QE RE+A Q +E +R + K+ E + RE+ E R ER +H
Sbjct: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 531
Query: 698 -----FQQQEQERQERRKRLEEIMKRTRKS 722
+QQ QER+ R LE + R +++
Sbjct: 532 LLQGRTRQQRQEREGLRSSLEASLGRAQEN 561
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 2/131 (1%)
Query: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKA 662
L ++ +E RER EQ RR +A+R R ++ Q + + E R R E + +
Sbjct: 478 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 537
Query: 663 QAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKS 722
+ +++E+E L+ E + R++E E + R+ ++ EQ +ERR LE R S
Sbjct: 538 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARAS 595
Query: 723 EVSETKQKQDS 733
K ++++
Sbjct: 596 FHVREKVREET 606
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL----QERRRRLEEQ 185
+E ++A R + ER EER + LA ++ + L +E +A RE +L QE+ + E+
Sbjct: 425 REEREAARRRQRQYERSEERRRELAERQGL-LRRERAERAAREDRLRKLQQEQNLKQREE 483
Query: 186 RLKAEQRRAALEERQR-QKLEKNKERYEAAIQRSVKK 221
L+ + RA R+R Q+ + K+R E +QR ++
Sbjct: 484 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 520
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 15/121 (12%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+++ ++ ER L + R ERA A + + ++E+ RE+ LQE R R E+ R
Sbjct: 441 SEERRRELAERQGLLRRERAERA---AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 497
Query: 188 KAEQRRAALEERQRQKLEKNKE--------RYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239
+ QR A ++RQ +L++ K R+EA +Q ++ RQ+R +L
Sbjct: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ----RQEREGLRSSLEA 553
Query: 240 S 240
S
Sbjct: 554 S 554
Score = 40.4 bits (93), Expect = 0.007
Identities = 140/697 (20%), Positives = 233/697 (33%), Gaps = 144/697 (20%)
Query: 79 PAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKA--- 135
P P +E++ + S G A P D++ + + S +A AS + P K EV A
Sbjct: 21 PVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASA-SASAAVPRKAEVPCAAAE 79
Query: 136 -----------------------GERHKLAKERREERAKYLAAKKAVWLEK-------EE 165
G R+ L R E A K L + E
Sbjct: 80 GGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARCAVKPVELLPRALADLVREA 139
Query: 166 KAKALREK----QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
+++R + E RR + Q+ +AE+ R EE++R
Sbjct: 140 PGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR-------------------- 179
Query: 222 TWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSP 281
+ + + A A S+P ++GS S S+ +LP ++ S S ++ P
Sbjct: 180 LFTPLSPAAAAAAAAAAASAP---SAGSSSSCSSASLPASPAPRAARKASPSPSSARTQP 236
Query: 282 SRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGR--A 339
S + +S +D L L+ A + +G P R A
Sbjct: 237 PPAGS--RTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPA 294
Query: 340 GASLARGPQPDRTHPSAAVPVCPRS-----ASASPLTPCSVTRSVHRC-APAGERGERRK 393
G++ + P R VP+ RS S SP T V R V + A G RG +
Sbjct: 295 GSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPER 354
Query: 394 PNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSA 453
+ R + E ++++ + E ++ + RER +++Q R +A
Sbjct: 355 DRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAA 414
Query: 454 STASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEE 513
+GR R +EE
Sbjct: 415 QVEER----------------------------------------------RGR-RGREE 427
Query: 514 AKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV 573
+ + ++S+ +RR E++ A A Q+EQ +
Sbjct: 428 REAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEG--- 484
Query: 574 LTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ----AREQREREEQER-RLQAERD 628
+ + A RE A R K+RQ RE+RE ER R +A
Sbjct: 485 ----------LQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 534
Query: 629 KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAE 688
R R+++ RE R+ EA R +E + E E+L +++ A +R A
Sbjct: 535 GRTRQQRQEREG-LRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR 593
Query: 689 RQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVS 725
F +E+ R+E R + M R + S
Sbjct: 594 AS-------FHVREKVREETNTRSFDRMVREAQLHAS 623
Score = 35.0 bits (79), Expect = 0.29
Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP-DTPPAMKNATSSKQLPLEPE 69
A P + R + PSP + PPP S + D+ + S +
Sbjct: 211 ASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSS 270
Query: 70 SPSGQV-----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQP----SPTAV 120
S SG+ P A + P+ A S P RP + P S +
Sbjct: 271 SYSGESLRELRWPPRASARNSCPAGSASSTTNAP-------GRPSALTLVPITGRSFSLG 323
Query: 121 PASDSPPTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQER 178
S SP T Q V++ + + + R ER + +AA + L + ++ L E Q
Sbjct: 324 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA---LMLARHQEELLLLE-QRAAA 379
Query: 179 RRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ 228
+ E QR+ A+QRR E +++ LE+ + + A ++ + E R+
Sbjct: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREERE 429
Score = 32.7 bits (73), Expect = 1.4
Identities = 63/274 (22%), Positives = 98/274 (35%), Gaps = 41/274 (14%)
Query: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA---------- 565
E+ ++ P+ + + AS+ SA+ A P + P ++EQ P
Sbjct: 39 EAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDC 98
Query: 566 -ETPTDAAVLTSPPA-PAPPVTPSKPMAGTTDREEATRLLAEKRRQA--REQR------E 615
E VLTSP + A KP+ E R LA+ R+A R R E
Sbjct: 99 PEAEGSRYVLTSPRSLEACARCAVKPV------ELLPRALADLVREAPGRSMRVATGLYE 152
Query: 616 REEQERRLQ-----AERDKRMREEQ---------LAREAEARAEREAEARRREEQEAREK 661
E ERR + AER++ MREE+ A A A A A + +
Sbjct: 153 AYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSAS 212
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721
A + + + AR++ R R+ H R+E E +
Sbjct: 213 LPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
Query: 722 SEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
S S ++ + A+A S P + +PG
Sbjct: 273 SGES-LRELRWPPRASARNSCPAGSASSTTNAPG 305
>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
Length = 627
Score = 96.3 bits (238), Expect = 1e-19
Identities = 98/364 (26%), Positives = 158/364 (43%), Gaps = 52/364 (14%)
Query: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPK--------SKARP 467
E++ K ++ E+ + RE K+R P SP A +A+ A+ +P S + P
Sbjct: 157 ERRAKLQQCRAERERIMREE--KRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSASLP 214
Query: 468 SSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDK 526
+SP+ R AS PSP T PP S G + S RR+E A S S A
Sbjct: 215 ASPAPRAARKAS--PSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
Query: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT-----DAAVLTSPPAPA 581
S R A+ + P+ + S T P + P L+ P A
Sbjct: 273 SGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTA 332
Query: 582 P-------PVTPSKPMAGTTDREEATRLLAEKRRQ----------------------ARE 612
V + + G +R+ L R Q A++
Sbjct: 333 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 392
Query: 613 QREREEQERRLQAERDKRMREEQL--AREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
+REREE+E++ E+ +R Q+ R R EREA RR+ + E E+ + E E++
Sbjct: 393 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 452
Query: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQK 730
L + +E AE +RE+ R +L++E++ +Q+E+ QE R+R E+I +R R + KQ+
Sbjct: 453 GLLR-RERAERAAREDRLR-KLQQEQNLKQREEGLQEGRERAEQI-RRERAQRAARAKQR 509
Query: 731 QDSK 734
Q+ +
Sbjct: 510 QEGQ 513
Score = 69.7 bits (169), Expect = 1e-11
Identities = 100/390 (25%), Positives = 158/390 (40%), Gaps = 45/390 (11%)
Query: 368 SPLTPCSVTRSVHRCAPAGERGERRKPNAGG---SPAP-VRRRPEASPVQKKEKKDKERE 423
+PL+P + + A A G ++ SPAP R+ SP + +
Sbjct: 182 TPLSPAAAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGS 241
Query: 424 NEKEKSALARERSLKKRQSLPASPRARLSASTASELS-----PKSKARPSSP----STSW 474
KS S ++ +L + A S+ + L P++ AR S P S++
Sbjct: 242 RTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTT 301
Query: 475 HRPASPC-----PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED-KSQ 528
+ P P P G +L SP+ TA R+ R+ A+ D K
Sbjct: 302 NAPGRPSALTLVPITGRSFSLGDLSHSPQ--TAQHVERIVRQVRAERGLRGVPERDRKIA 359
Query: 529 SKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAET-PTDAAVLTSPPAPAPPVTPS 587
+ A +++E A + K++ E A+ A A V
Sbjct: 360 ALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEER 419
Query: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD---KRMREEQLAREAEARA 644
+ G +RE A R+ + Q ER E+ RR AER +R R E+ ARE R
Sbjct: 420 RGRRGREEREAA--------RRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRK 471
Query: 645 -EREAEARRREE--QEAREKA-QAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKH-- 697
++E ++REE QE RE+A Q +E +R + K+ E + RE+ E R ER +H
Sbjct: 472 LQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEA 531
Query: 698 -----FQQQEQERQERRKRLEEIMKRTRKS 722
+QQ QER+ R LE + R +++
Sbjct: 532 LLQGRTRQQRQEREGLRSSLEASLGRAQEN 561
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 2/131 (1%)
Query: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKA 662
L ++ +E RER EQ RR +A+R R ++ Q + + E R R E + +
Sbjct: 478 LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRT 537
Query: 663 QAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKS 722
+ +++E+E L+ E + R++E E + R+ ++ EQ +ERR LE R S
Sbjct: 538 RQQRQEREGLRSSLEASLGRAQENYEHLAIGRK--LERSEQLTRERRSALESARSTARAS 595
Query: 723 EVSETKQKQDS 733
K ++++
Sbjct: 596 FHVREKVREET 606
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL----QERRRRLEEQ 185
+E ++A R + ER EER + LA ++ + L +E +A RE +L QE+ + E+
Sbjct: 425 REEREAARRRQRQYERSEERRRELAERQGL-LRRERAERAAREDRLRKLQQEQNLKQREE 483
Query: 186 RLKAEQRRAALEERQR-QKLEKNKERYEAAIQRSVKK 221
L+ + RA R+R Q+ + K+R E +QR ++
Sbjct: 484 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 520
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 15/121 (12%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+++ ++ ER L + R ERA A + + ++E+ RE+ LQE R R E+ R
Sbjct: 441 SEERRRELAERQGLLRRERAERA---AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 497
Query: 188 KAEQRRAALEERQRQKLEKNKE--------RYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239
+ QR A ++RQ +L++ K R+EA +Q ++ RQ+R +L
Sbjct: 498 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ----RQEREGLRSSLEA 553
Query: 240 S 240
S
Sbjct: 554 S 554
Score = 40.4 bits (93), Expect = 0.007
Identities = 140/697 (20%), Positives = 233/697 (33%), Gaps = 144/697 (20%)
Query: 79 PAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKA--- 135
P P +E++ + S G A P D++ + + S +A AS + P K EV A
Sbjct: 21 PVPEEEKAGAEPGDSGGDEAVASVPPDSQGAQEPAASSASA-SASAAVPRKAEVPCAAAE 79
Query: 136 -----------------------GERHKLAKERREERAKYLAAKKAVWLEK-------EE 165
G R+ L R E A K L + E
Sbjct: 80 GGRREQSPLLHLDLFNFDCPEAEGSRYVLTSPRSLEACARCAVKPVELLPRALADLVREA 139
Query: 166 KAKALREK----QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
+++R + E RR + Q+ +AE+ R EE++R
Sbjct: 140 PGRSMRVATGLYEAYEAERRAKLQQCRAERERIMREEKRR-------------------- 179
Query: 222 TWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSP 281
+ + + A A S+P ++GS S S+ +LP ++ S S ++ P
Sbjct: 180 LFTPLSPAAAAAAAAAAASAP---SAGSSSSCSSASLPASPAPRAARKASPSPSSARTQP 236
Query: 282 SRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGR--A 339
S + +S +D L L+ A + +G P R A
Sbjct: 237 PPAGS--RTGRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPA 294
Query: 340 GASLARGPQPDRTHPSAAVPVCPRS-----ASASPLTPCSVTRSVHRC-APAGERGERRK 393
G++ + P R VP+ RS S SP T V R V + A G RG +
Sbjct: 295 GSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTAQHVERIVRQVRAERGLRGVPER 354
Query: 394 PNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSA 453
+ R + E ++++ + E ++ + RER +++Q R +A
Sbjct: 355 DRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAA 414
Query: 454 STASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEE 513
+GR R +EE
Sbjct: 415 QVEER----------------------------------------------RGR-RGREE 427
Query: 514 AKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV 573
+ + ++S+ +RR E++ A A Q+EQ +
Sbjct: 428 REAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQQEQNLKQREEG--- 484
Query: 574 LTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ----AREQREREEQER-RLQAERD 628
+ + A RE A R K+RQ RE+RE ER R +A
Sbjct: 485 ----------LQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQ 534
Query: 629 KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAE 688
R R+++ RE R+ EA R +E + E E+L +++ A +R A
Sbjct: 535 GRTRQQRQEREG-LRSSLEASLGRAQENYEHLAIGRKLERSEQLTRERRSALESARSTAR 593
Query: 689 RQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVS 725
F +E+ R+E R + M R + S
Sbjct: 594 AS-------FHVREKVREETNTRSFDRMVREAQLHAS 623
Score = 35.0 bits (79), Expect = 0.29
Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP-DTPPAMKNATSSKQLPLEPE 69
A P + R + PSP + PPP S + D+ + S +
Sbjct: 211 ASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSS 270
Query: 70 SPSGQV-----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQP----SPTAV 120
S SG+ P A + P+ A S P RP + P S +
Sbjct: 271 SYSGESLRELRWPPRASARNSCPAGSASSTTNAP-------GRPSALTLVPITGRSFSLG 323
Query: 121 PASDSPPTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQER 178
S SP T Q V++ + + + R ER + +AA + L + ++ L E Q
Sbjct: 324 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA---LMLARHQEELLLLE-QRAAA 379
Query: 179 RRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ 228
+ E QR+ A+QRR E +++ LE+ + + A ++ + E R+
Sbjct: 380 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREERE 429
Score = 32.7 bits (73), Expect = 1.4
Identities = 63/274 (22%), Positives = 98/274 (35%), Gaps = 41/274 (14%)
Query: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA---------- 565
E+ ++ P+ + + AS+ SA+ A P + P ++EQ P
Sbjct: 39 EAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDC 98
Query: 566 -ETPTDAAVLTSPPA-PAPPVTPSKPMAGTTDREEATRLLAEKRRQA--REQR------E 615
E VLTSP + A KP+ E R LA+ R+A R R E
Sbjct: 99 PEAEGSRYVLTSPRSLEACARCAVKPV------ELLPRALADLVREAPGRSMRVATGLYE 152
Query: 616 REEQERRLQ-----AERDKRMREEQ---------LAREAEARAEREAEARRREEQEAREK 661
E ERR + AER++ MREE+ A A A A A + +
Sbjct: 153 AYEAERRAKLQQCRAERERIMREEKRRLFTPLSPAAAAAAAAAAASAPSAGSSSSCSSAS 212
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721
A + + + AR++ R R+ H R+E E +
Sbjct: 213 LPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 272
Query: 722 SEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
S S ++ + A+A S P + +PG
Sbjct: 273 SGES-LRELRWPPRASARNSCPAGSASSTTNAPG 305
>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
Length = 625
Score = 95.9 bits (237), Expect = 1e-19
Identities = 100/364 (27%), Positives = 156/364 (42%), Gaps = 54/364 (14%)
Query: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWH 475
E++ K ++ E+ + RE K+R P SP A +A+ AS S S + SS S
Sbjct: 157 ERRAKLQQCRAERDRIMREE--KRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASL--- 211
Query: 476 RPASPCP--------SPGPGHTLPPKPPSPRGTTA-SPKGRVRRKEEAKESPSAAGPEDK 526
PASP P SP T PP S G + S RR+E A S S A
Sbjct: 212 -PASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSY 270
Query: 527 SQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT-----DAAVLTSPPAPA 581
S R A+ + P+ + S T P + P L+ P A
Sbjct: 271 SGESLRELRWPPRASARNSCPAGSASSTTNAPGRPSALTLVPITGRSFSLGDLSHSPQTA 330
Query: 582 P-------PVTPSKPMAGTTDREEATRLLAEKRRQ----------------------ARE 612
V + + G +R+ L R Q A++
Sbjct: 331 QHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVHAKQ 390
Query: 613 QREREEQERRLQAERDKRMREEQL--AREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
+REREE+E++ E+ +R Q+ R R EREA RR+ + E E+ + E E++
Sbjct: 391 RREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQ 450
Query: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQK 730
L + +E AE +RE+ R +L++E++ +Q+E+ QE R+R E+I +R R + KQ+
Sbjct: 451 GLLR-RERAERAAREDRLR-KLQQEQNLKQREEGLQEGRERAEQI-RRERAQRAARAKQR 507
Query: 731 QDSK 734
Q+ +
Sbjct: 508 QEGQ 511
Score = 72.4 bits (176), Expect = 2e-12
Identities = 101/388 (26%), Positives = 158/388 (40%), Gaps = 43/388 (11%)
Query: 368 SPLTPCSVTRSVHRCAP-AGERGERRKPNAGGSPAP-VRRRPEASPVQKKEKKDKERENE 425
+PL+P + + AP AG + SPAP R+ SP + +
Sbjct: 182 TPLSPAAAAAAAAASAPSAGSSSSCSSASLPASPAPRAARKASPSPSSARTQPPPAGSRT 241
Query: 426 KEKSALARERSLKKRQSLPASPRARLSASTASELS-----PKSKARPSSP----STSWHR 476
KS S ++ +L + A S+ + L P++ AR S P S++ +
Sbjct: 242 GRKSHSLDSLSRRREGALSSESGASSSSYSGESLRELRWPPRASARNSCPAGSASSTTNA 301
Query: 477 PASPC-----PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED-KSQSK 530
P P P G +L SP+ TA R+ R+ A+ D K +
Sbjct: 302 PGRPSALTLVPITGRSFSLGDLSHSPQ--TAQHVERIVRQVRAERGLRGVPERDRKIAAL 359
Query: 531 RRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAET-PTDAAVLTSPPAPAPPVTPSKP 589
A +++E A + K++ E A+ A A V +
Sbjct: 360 MLARHQEELLLLEQRAAAHGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRG 419
Query: 590 MAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERD---KRMREEQLAREAEARA-E 645
G +RE A R+ + Q ER E+ RR AER +R R E+ ARE R +
Sbjct: 420 RRGREEREAA--------RRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLRKLQ 471
Query: 646 REAEARRREE--QEAREKA-QAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKH---- 697
+E ++REE QE RE+A Q +E +R + K+ E + RE+ E R ER +H
Sbjct: 472 QEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEALL 531
Query: 698 ---FQQQEQERQERRKRLEEIMKRTRKS 722
+QQ QER+ R LE + R +++
Sbjct: 532 QGRTRQQRQEREGLRSSLEASLGRAQEN 559
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/97 (30%), Positives = 53/97 (54%), Gaps = 6/97 (6%)
Query: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL----QERRRRLEEQ 185
+E ++A R + ER EER + LA ++ + L +E +A RE +L QE+ + E+
Sbjct: 423 REEREAARRRQRQYERSEERRRELAERQGL-LRRERAERAAREDRLRKLQQEQNLKQREE 481
Query: 186 RLKAEQRRAALEERQR-QKLEKNKERYEAAIQRSVKK 221
L+ + RA R+R Q+ + K+R E +QR ++
Sbjct: 482 GLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRE 518
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 15/121 (12%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+++ ++ ER L + R ERA A + + ++E+ RE+ LQE R R E+ R
Sbjct: 439 SEERRRELAERQGLLRRERAERA---AREDRLRKLQQEQNLKQREEGLQEGRERAEQIRR 495
Query: 188 KAEQRRAALEERQRQKLEKNKE--------RYEAAIQRSVKKTWAEIRQQRWSWAGALHH 239
+ QR A ++RQ +L++ K R+EA +Q ++ RQ+R +L
Sbjct: 496 ERAQRAARAKQRQEGQLQREKRELSRAERARHEALLQGRTRQQ----RQEREGLRSSLEA 551
Query: 240 S 240
S
Sbjct: 552 S 552
Score = 38.5 bits (88), Expect = 0.026
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 2/74 (2%)
Query: 139 HKLAKERREERAKYLAAKKA--VWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
H + REER K A ++ W + E+ + R ++ +E RR + Q ++E+RR L
Sbjct: 387 HAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRREL 446
Query: 197 EERQRQKLEKNKER 210
ERQ + ER
Sbjct: 447 AERQGLLRRERAER 460
Score = 35.0 bits (79), Expect = 0.29
Identities = 53/230 (23%), Positives = 89/230 (38%), Gaps = 23/230 (10%)
Query: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPP-DTPPAMKNATSSKQLPLEPE 69
A P + R + PSP + PPP S + D+ + S +
Sbjct: 209 ASLPASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSS 268
Query: 70 SPSGQV-----GPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQP----SPTAV 120
S SG+ P A + P+ A S P RP + P S +
Sbjct: 269 SYSGESLRELRWPPRASARNSCPAGSASSTTNAP-------GRPSALTLVPITGRSFSLG 321
Query: 121 PASDSPPTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQER 178
S SP T Q V++ + + + R ER + +AA + L + ++ L E Q
Sbjct: 322 DLSHSPQTAQHVERIVRQVRAERGLRGVPERDRKIAA---LMLARHQEELLLLE-QRAAA 377
Query: 179 RRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQ 228
+ E QR+ A+QRR E +++ LE+ + + A ++ + E R+
Sbjct: 378 HGQWELQRVHAKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREERE 427
Score = 33.1 bits (74), Expect = 1.1
Identities = 65/272 (23%), Positives = 98/272 (36%), Gaps = 39/272 (14%)
Query: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA---------- 565
E+ ++ P+ + + AS+ SA+ A P + P ++EQ P
Sbjct: 39 EAVASVPPDSQGAQEPAASSASASASAAVPRKAEVPCAAAEGGRREQSPLLHLDLFNFDC 98
Query: 566 -ETPTDAAVLTSPPA-PAPPVTPSKPMAGTTDREEATRLLAEKRRQA--REQR------E 615
E VLTSP + A KP+ E R LA+ R+A R R E
Sbjct: 99 PEAEGSRYVLTSPRSLEACARCAVKPV------ELLPRALADLVREAPGRSMRVATGLYE 152
Query: 616 REEQERRLQ-----AERDKRMREEQL-----AREAEARAEREAEARRREEQEAREKAQAE 665
E ERR + AERD+ MREE+ A A A A A + A
Sbjct: 153 AYEAERRAKLQQCRAERDRIMREEKRRLFTPLSPAAAAAAAAASAPSAGSSSSCSSASLP 212
Query: 666 QEEQERLQKQ--KEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
R ++ + AR++ R R+ H R+E E + S
Sbjct: 213 ASPAPRAARKASPSPSSARTQPPPAGSRTGRKSHSLDSLSRRREGALSSESGASSSSYSG 272
Query: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
S ++ + A+A S P + +PG
Sbjct: 273 ES-LRELRWPPRASARNSCPAGSASSTTNAPG 303
Score = 30.4 bits (67), Expect = 7.2
Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 12/112 (10%)
Query: 129 KQEVKKAGERHKLAK--ERREERAKY----LAAKKAVWLEKEEKAKALREKQLQERRRRL 182
KQ + G R A+ ERR R + ++ + EE+ + L E+Q RR R
Sbjct: 399 KQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLRRERA 458
Query: 183 E----EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E E RL+ Q+ L++R+ + L++ +ER E I+R + A +Q++
Sbjct: 459 ERAAREDRLRKLQQEQNLKQRE-EGLQEGRERAE-QIRRERAQRAARAKQRQ 508
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 89.4 bits (220), Expect = 1e-17
Identities = 50/154 (32%), Positives = 93/154 (60%), Gaps = 12/154 (7%)
Query: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAERE 647
K G +EE R +KRR+ +E +E EE+E+R + E+ +R R + +E E + ER+
Sbjct: 84 KEKKGERKKEERER---KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERK 140
Query: 648 AEAR----RREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ 703
E R R++E+ +E+ + E++++ER Q ++E E + +E ER++ ER + +++E+
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Query: 704 ERQERRKRLEEIMKRTRKSEVSETKQKQDSKEAN 737
ER+ERR+R K+ RK + K++Q ++ N
Sbjct: 201 ERKERRER-----KKERKKKEERKKERQKDRQTN 229
Score = 79.7 bits (195), Expect = 1e-14
Identities = 57/179 (31%), Positives = 98/179 (54%), Gaps = 12/179 (6%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREA---EARAEREAEARRREEQEAREK 661
E R++ +++RE E ++ R + E+ KR RE++ RE E + ER+ E R R+++ REK
Sbjct: 46 ETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRR-REK 104
Query: 662 AQAEQEEQE-RLQKQKEEAEARSREEAERQRLEREKHFQQQEQER----QERRKRLEEIM 716
E EE+E R +K+K+E S+E ER+R E K +++E+ER +E+ + +E
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERK 164
Query: 717 KRTRK---SEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
KR RK + E K+K+ + + E K E + +K+ +K+E +E Q
Sbjct: 165 KRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQ 223
Score = 79.3 bits (194), Expect = 1e-14
Identities = 44/179 (24%), Positives = 97/179 (54%), Gaps = 13/179 (7%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
+RE+ R ++R++ R ++E++ + ++ + ER KR RE++ +E E + +R+ + ++
Sbjct: 65 EREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKE-NKEGEEKEKRKKKEKKER 123
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
+ ++E + E++E+ + +++KE + E ER+R ER+K ++Q E++E RK E
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183
Query: 715 IMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQW 773
++ R+ E K++++ KE E + +KE +KE ++ W
Sbjct: 184 KERKKRERNRKERKKERERKERR------------ERKKERKKKEERKKERQKDRQTNW 230
Score = 73.6 bits (179), Expect = 7e-13
Identities = 59/226 (26%), Positives = 112/226 (49%), Gaps = 16/226 (7%)
Query: 493 KPPSPRGTTASPKGRVR----RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPS 548
KP + G + + R R RKE KE S E + + KR+ EKE
Sbjct: 27 KPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK 86
Query: 549 PAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKR- 607
+K++ + + K G T +E R E+R
Sbjct: 87 KGERKKEERERKKRRREKENKEGEEKEKRKKK------EKKERGRTSKEGKERERKEERK 140
Query: 608 RQAREQREREEQERRLQAERDKRMREE--QLAREAEARAEREAEARRREEQEAREKAQAE 665
R+ R++RER+++ER + ER +R + E Q+ + E R E+E + R++ E+ +E+ + E
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER-KKE 199
Query: 666 QEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKR 711
+E +ER +++KE + R++ ERQ+ +R+ +++++E+ ++ER++R
Sbjct: 200 RERKERRERKKERKKKEERKK-ERQK-DRQTNWREKERGKRERKER 243
Score = 67.8 bits (164), Expect = 4e-11
Identities = 49/173 (28%), Positives = 92/173 (53%), Gaps = 13/173 (7%)
Query: 604 AEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQ 663
+E R + RE R+E ++ ++ER K RE + + + ERE E R+RE + +K +
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERRERE-----KRKREREKE-RKRERGKKEKKGE 89
Query: 664 AEQEEQERLQKQKEEAEARSREEAERQRLEREKH----FQQQEQERQERRKRLEEIMKRT 719
++EE+ER ++++E+ E+ +R++ E+++ + +E+ER+E RKR EE +R
Sbjct: 90 RKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR-EERKERE 148
Query: 720 RKSE--VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
RK E E ++K+ K E + + R ++E +KE +E
Sbjct: 149 RKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201
Score = 50.8 bits (120), Expect = 5e-06
Identities = 61/274 (22%), Positives = 102/274 (37%), Gaps = 63/274 (22%)
Query: 398 GSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTAS 457
G + +R R +K+ KK ERE+E++K RER +KR+ R R
Sbjct: 33 GWQSEIREREREIETRKEGKK--ERESERKKE--RREREKRKREREKERKRERGKKEKKG 88
Query: 458 ELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKES 517
E + + R ++ K RG T+ RKEE K
Sbjct: 89 ERKKEERERKKRRREKENKEGE------EKEKRKKKEKKERGRTSKEGKERERKEERKRE 142
Query: 518 PSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSP 577
E K + +++ EKE +KE+ E
Sbjct: 143 ------ERKERERKKEEREKER------------------ERKERKKRE----------- 167
Query: 578 PAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLA 637
+ G + E EK R+ R++RER +ER+ + ER +R +
Sbjct: 168 ----------RKQVGEKEEER-----KEKERKERKKRERNRKERKKERERKERRERK--- 209
Query: 638 REAEARAEREAEARRREEQEAREKAQAEQEEQER 671
+E + + ER+ E ++ + REK + ++E +ER
Sbjct: 210 KERKKKEERKKERQKDRQTNWREKERGKRERKER 243
Score = 48.9 bits (115), Expect = 2e-05
Identities = 30/106 (28%), Positives = 55/106 (51%), Gaps = 4/106 (3%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRR----LEE 184
K+E K+ G K KER + + +K +KEE+ K K+ ++R R+ EE
Sbjct: 117 KKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEE 176
Query: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+R + E++ ER R++ +K +ER E ++ +K E +++R
Sbjct: 177 ERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKER 222
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 2/104 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE--EQR 186
K+ ++ G++ K + ++EER + ++ E EEK K ++++ + R E E+
Sbjct: 75 KERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERE 134
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
K E++R +ER+R+K E+ KER ++ +K E ++R
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEER 178
Score = 46.6 bits (109), Expect = 1e-04
Identities = 36/143 (25%), Positives = 64/143 (44%), Gaps = 22/143 (15%)
Query: 83 QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA 142
+E+ E K RG T R+ + R+ + ++ K+ E+ +
Sbjct: 112 KEKRKKKEKKERGRTSKEGKERERKEERKREERKE-----------RERKKEEREKERER 160
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQ 202
KER++ K + K E+E K K +E++ +ER R+ +R K +R+ E R+R+
Sbjct: 161 KERKKRERKQVGEK-----EEERKEKERKERKKRERNRK---ERKKERERK---ERRERK 209
Query: 203 KLEKNKERYEAAIQRSVKKTWAE 225
K K KE + Q+ + W E
Sbjct: 210 KERKKKEERKKERQKDRQTNWRE 232
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/117 (29%), Positives = 64/117 (54%), Gaps = 10/117 (8%)
Query: 655 EQEAREKAQAEQEEQERLQKQKE-EAE-ARSREEAERQRLEREKHFQQQ---EQERQERR 709
+ E RE+ E+E + R + +KE E+E + R E E+++ EREK +++ ++++ ER+
Sbjct: 35 QSEIRER---EREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERK 91
Query: 710 KRLEEIMKRTRKSE--VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE 764
K E KR R+ E E K+K+ KE G + + K E + ++E ++E
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE 148
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/106 (25%), Positives = 57/106 (53%), Gaps = 6/106 (5%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKAL----REKQLQERRRRLEE 184
++E K+ E+ K K+ ++ER + +K+ E++E+ K RE++ +ER + E
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGR--TSKEGKERERKEERKREERKERERKKEEREKERER 160
Query: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ K +R+ E+ + +K ++ KER + R +K E +++R
Sbjct: 161 KERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERR 206
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/95 (29%), Positives = 49/95 (51%), Gaps = 6/95 (6%)
Query: 133 KKAGERHKLAKER---REERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKA 189
+K GER K +ER R E+ +K +KE+K + K+ +ER R+ E +R +
Sbjct: 85 EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 190 EQRRAALEERQRQ---KLEKNKERYEAAIQRSVKK 221
++R EER+++ K K +ER + + +K
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERK 179
Score = 38.1 bits (87), Expect = 0.034
Identities = 28/91 (30%), Positives = 47/91 (51%), Gaps = 19/91 (20%)
Query: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
E +K G+ KER ER K E+ E+ K RE++ + +R R ++++ K E
Sbjct: 46 ETRKEGK-----KERESERKK----------ERREREKRKREREKERKRERGKKEK-KGE 89
Query: 191 QRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
+++ EER+R+K + KE E + KK
Sbjct: 90 RKK---EERERKKRRREKENKEGEEKEKRKK 117
Score = 36.6 bits (83), Expect = 0.100
Identities = 24/106 (22%), Positives = 53/106 (50%), Gaps = 4/106 (3%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALRE----KQLQERRRRLEE 184
K+ +K ER + + R +E + +K EK+E+ + +E ++ +ER+R +
Sbjct: 86 KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Query: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+R + ++ R ER+ +K + K+ E +R K+ +++R
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191
Score = 34.7 bits (78), Expect = 0.38
Identities = 26/121 (21%), Positives = 53/121 (43%), Gaps = 11/121 (9%)
Query: 83 QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA 142
+EE E K R R R+ + + +++ +K ER++
Sbjct: 136 KEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR-- 193
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQ 202
KER++ER + E+ E+ K ++K+ +++ R+ + Q E+ R E ++R+
Sbjct: 194 KERKKERER---------KERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Query: 203 K 203
K
Sbjct: 245 K 245
Score = 32.3 bits (72), Expect = 1.9
Identities = 29/152 (19%), Positives = 52/152 (34%), Gaps = 2/152 (1%)
Query: 387 ERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS 446
ER + RK G R+ E +K+ ++ + +E E+++ +E+ + R S
Sbjct: 72 EREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK 131
Query: 447 PRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKG 506
R R E + + + + G + R K
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER--KERKKR 189
Query: 507 RVRRKEEAKESPSAAGPEDKSQSKRRASNEKE 538
RKE KE E K + K++ +KE
Sbjct: 190 ERNRKERKKERERKERRERKKERKKKEERKKE 221
Score = 32.3 bits (72), Expect = 1.9
Identities = 21/88 (23%), Positives = 38/88 (43%), Gaps = 3/88 (3%)
Query: 387 ERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS 446
ER +++ R++ E V +KE++ KE+E ++ K RER+ K+R+
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKK---RERNRKERKKERER 202
Query: 447 PRARLSASTASELSPKSKARPSSPSTSW 474
R + + K R T+W
Sbjct: 203 KERRERKKERKKKEERKKERQKDRQTNW 230
Score = 30.8 bits (68), Expect = 5.5
Identities = 18/68 (26%), Positives = 37/68 (54%), Gaps = 4/68 (5%)
Query: 161 LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVK 220
+E ++ K RE + ++ RR E+++ + E+ R +R+R K EK ER + +R +
Sbjct: 45 IETRKEGKKERESERKKERREREKRKREREKER----KRERGKKEKKGERKKEERERKKR 100
Query: 221 KTWAEIRQ 228
+ E ++
Sbjct: 101 RREKENKE 108
Score = 30.4 bits (67), Expect = 7.2
Identities = 15/60 (25%), Positives = 34/60 (56%)
Query: 162 EKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
E+E + + +E + + R +E+R + +++R +ER+R++ +K K+ +R KK
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKK 99
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 88.6 bits (218), Expect = 2e-17
Identities = 155/644 (24%), Positives = 214/644 (33%), Gaps = 84/644 (13%)
Query: 6 RAELGAGA-PPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMK-----NAT 59
+A+ GA A PA AR P P P G P PPPP TP A++ A
Sbjct: 7 KAKAGAAARTPA--ARAPGLLTPRPPGSPRPPPPV-----------TPAALRVLGAAGAV 53
Query: 60 SSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPT--PPAMGPRDARPPRRSSQPSP 117
K L G P AP + S+ SR P PPA G + PP +++ P P
Sbjct: 54 GRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGP 113
Query: 118 TAVPASDSPPTK-----QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALRE 172
+ P S T+ Q+ + +A+ + E K A +
Sbjct: 114 VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 173
Query: 173 KQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWS 232
+ R R + R A R R E ++ +A + S + + ++R S
Sbjct: 174 PAMARRSRAAGTE---VGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEP-SPAARRRPS 229
Query: 233 WAGALHH-------SSPGHKTSGSRCSVSAVNLPK---HVDSIINKRLSKSSATLWNSPS 282
G L SS +S +R SA P+ H K L P
Sbjct: 230 AGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR 289
Query: 283 RNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGR----GPTWGR 338
++ + L SS L TP+ S +S++ TLP C P
Sbjct: 290 KDAAPALGPLSSS---PLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPS 346
Query: 339 AGASLARGPQPDRTHPSAAV-----PVCPRSASASPLTPCSVTRSVHRCAPAGERGERRK 393
A SL P P T PS A P + S P P S + AP
Sbjct: 347 APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPA----LAL 402
Query: 394 PNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSA 453
P P+P P + P+ + N L S + A S
Sbjct: 403 PPLQAPPSP----PASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
Query: 454 STASELSPKSKARPSSPSTSWHRPASPCPSP--GPGHTLPPKPPSP---------RGTTA 502
+ +P S+A PS + P SP SP P T PP+ P P +
Sbjct: 459 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 518
Query: 503 SPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPA------------PSPA 550
+P +A SP A+ P S + A P A PSP
Sbjct: 519 APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPP 578
Query: 551 PSPT-PAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGT 593
SPT AP + P +T LT AP PP PS+ + T
Sbjct: 579 ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSST 622
Score = 70.1 bits (170), Expect = 8e-12
Identities = 83/302 (27%), Positives = 114/302 (37%), Gaps = 47/302 (15%)
Query: 337 GRAGASLARGPQPDR-------THPSAAVPVCP-RSASASPLTPCSVTRSVHRCAPAGER 388
G AGA + R P +R T P +A P RSA S P S PA R
Sbjct: 48 GAAGA-VGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRP-------PASGR 99
Query: 389 GERRKPNAGGSPAPVRRRPEASPVQKKEKKDKE--RENEKEKSALARERSLKKRQSLPAS 446
GER P SP PV AS + ++ R + +E A + KR +L A
Sbjct: 100 GERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAG 159
Query: 447 PRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKG 506
R S T SP R + T P P PS P P + P ++AS
Sbjct: 160 ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR-PAPSARPRP--PTEGPRKSVSSASEHS 216
Query: 507 RVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPS-------------PAPS- 552
A+ PSA G + S+ +S+ ++PA PS P P
Sbjct: 217 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKG 276
Query: 553 ------PTPAPPQKEQPPAETPTDAAVLTSP------PAPAPPVTPSKPMAGTTDREEAT 600
P PP+K+ PA P ++ L +P + APP P+ P + + + AT
Sbjct: 277 LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLAT 336
Query: 601 RL 602
L
Sbjct: 337 PL 338
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/141 (32%), Positives = 57/141 (40%), Gaps = 25/141 (17%)
Query: 5 PRAELGAGAPPAVVARTPPEPRP-SPEGDPSP----------------PPPPMSALVPDT 47
P+A PP +PP P SP PSP PPP P +
Sbjct: 394 PQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFS 453
Query: 48 PPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRD-A 106
PP +PP +AT Q P +P QV P P P+S S TPP P A
Sbjct: 454 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSP-------PASPPMSPSATPPPQAPPPLA 506
Query: 107 RPPRRSSQPSPTAVPASDSPP 127
PP + ++P P A PA +PP
Sbjct: 507 APPLQLAKPPPQAPPALATPP 527
Score = 43.5 bits (101), Expect = 8e-04
Identities = 39/145 (26%), Positives = 59/145 (40%), Gaps = 16/145 (11%)
Query: 5 PRAELGAGAPPAVVARTPPEPRPSP-----EGDPSPP-------PPPMSALVPDTPPDTP 52
P+A APP +A+ PP+ P+ + PSPP P SA +P +P TP
Sbjct: 499 PQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
Query: 53 PAMKNATSSKQL----PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP 108
P + L P P SP+ Q RP P ++ S + P P +R
Sbjct: 559 PPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
Query: 109 PRRSSQPSPTAVPASDSPPTKQEVK 133
P + A +S + T +E++
Sbjct: 619 PSSTLSGPDLAGHSSSATSTPEELR 643
Score = 38.9 bits (89), Expect = 0.020
Identities = 69/266 (25%), Positives = 94/266 (35%), Gaps = 59/266 (22%)
Query: 354 PSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQ 413
P A+ PV P SA+ P S+ + P+ P+A +P P P A+P
Sbjct: 454 PPASPPVSP-SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA--TPPPQAPPPLAAPPL 510
Query: 414 KKEKKDKERENEKEKSALARERSLKKRQSLPASP-----RARLSASTASELSPKSKARPS 468
+ K + L Q+LP+ P +A S S + +SP + P
Sbjct: 511 QLAKPPPQAPPALATPPL---------QALPSPPASFPGQAPFSPSASLPMSPLATPPPQ 561
Query: 469 SP--------STSWHRPASPC-------PSPGPGHT---------LPPKPPSPRGTTASP 504
+P PASP P+PGP + L P PP P + SP
Sbjct: 562 APPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPP--PSRSP 619
Query: 505 KGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSP--------APSPTPA 556
+ + A S SA ++ R + E A ASP P A S PA
Sbjct: 620 SSTLSGPDLAGHSSSATSTPEEL---RGYDSGPEGGAAASPPPDAELAACHPAAWSRGPA 676
Query: 557 PPQKEQPPAETPTDAAVLTSPPAPAP 582
PP A A L PPA P
Sbjct: 677 PPL-----AFRGAPGAPLPWPPATGP 697
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 87.8 bits (216), Expect = 4e-17
Identities = 51/146 (34%), Positives = 89/146 (60%), Gaps = 9/146 (6%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAE----REAEAR 651
RE+ R E+ R+ +++ RE+QERR E+ + RE+QL RE E R E RE E
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERR---EQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 652 RREEQEAREKAQAEQEEQERLQKQ--KEEAEARSREEAERQRLEREKHFQQQEQERQERR 709
RRE+Q RE+ + +E+Q R ++Q +E+ R ++ Q+L RE+ ++++Q R+E++
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 710 KRLEEIMKRTRKSEVSETKQKQDSKE 735
R E+ ++R ++ E E K +Q+ +E
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERRE 444
Score = 86.3 bits (212), Expect = 1e-16
Identities = 95/394 (24%), Positives = 168/394 (42%), Gaps = 32/394 (8%)
Query: 387 ERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS 446
E E R+ S RR + +++E++++ + E+E+ L E+ LK+
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL--EQRLKREHE---- 677
Query: 447 PRARLSASTASELSPKSKARPSS--PSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASP 504
R A E +++ R S P W + ++ P K R
Sbjct: 678 -EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 505 KGRVRRKEEAK-ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQP 563
+ R RR+ E + + A + + + +RR + A S S P P +EQ
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP--PLREQR 794
Query: 564 PAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQRERE--EQER 621
+ + + +RE+ + L E+ + R +R ++ E+E
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED 854
Query: 622 RLQAERDKRMREEQLAREAEARAEREAEARRRE---------EQEAREKAQAEQEEQERL 672
LQ ++++R +EQ R+ + R + E E +RR +++ R++ Q QEE+E L
Sbjct: 855 GLQEDQERRRSQEQ-RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 673 QKQKEEAEARSREEAERQRLEREKHFQQQEQ-ERQERRKRLEEIMKRTRKSEVSETKQKQ 731
Q+EE E R R+E ERQ E E+ Q++EQ R+ER KR + +R + + +K
Sbjct: 914 --QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-----KKL 966
Query: 732 DSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
KE G PE + E ++E +Q+EE
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Score = 83.2 bits (204), Expect = 9e-16
Identities = 45/139 (32%), Positives = 82/139 (58%), Gaps = 2/139 (1%)
Query: 593 TTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
T R+E +L E+ ++ RE +E EEQ R+L ER + RE Q + + R RE + RR
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKL--ERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 653 REEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRL 712
++E+E RE+ + +E+QER ++Q+E E + R E E +R ++ + Q++E+ Q+ R+
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ 368
Query: 713 EEIMKRTRKSEVSETKQKQ 731
EE + + + +++Q
Sbjct: 369 EEERREQQLRREQQLRREQ 387
Score = 82.8 bits (203), Expect = 1e-15
Identities = 63/201 (31%), Positives = 107/201 (53%), Gaps = 22/201 (10%)
Query: 596 REEATRLLAEKRR---QAREQREREEQERR---LQAERDKRMREEQLAREAEARAE---R 646
RE+ + E+RR + E+ ER EQERR L+ ++++ RE L E E R E R
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Query: 647 EAEARRREEQEAREKAQAEQEEQERLQKQ--KEEAEARSREEAERQRLEREKHFQQQEQE 704
+ RRE++E RE+ QEE+ERLQ++ E+ R +EE Q L+RE+ + +++
Sbjct: 503 REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 705 RQERRKRLEE-----IMKRTRKSEVSETKQKQDSK-EANANGSSPEPVKAVEARSPGLQK 758
R++R KR +E ++KR + K++Q+ + E E ++ E R +
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR-----E 617
Query: 759 EAVQKEEPIPQEPQWSLPSKE 779
+ +++EEP + Q L S+E
Sbjct: 618 QRLKREEPEEERRQQLLKSEE 638
Score = 82.4 bits (202), Expect = 2e-15
Identities = 47/141 (33%), Positives = 84/141 (59%), Gaps = 6/141 (4%)
Query: 596 REEATRLLAEKRRQAREQREREEQ--ERRLQAERDKRMREEQLAREAEARAEREAEARRR 653
RE+ R E+RR+ + +RE+EE+ E++L+ E+++ RE+QL RE + R E++ R
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL----R 390
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713
EQ+ R + Q +E+Q R ++Q + RE+ R+ E E+H Q+ EQER+E+R + E
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 714 EIMKRTRKSEVSETKQKQDSK 734
+ +R ET++ + +
Sbjct: 451 QEERRDWLKREEETERHEQER 471
Score = 81.6 bits (200), Expect = 3e-15
Identities = 58/165 (35%), Positives = 96/165 (58%), Gaps = 12/165 (7%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQ-LAREAEARAEREAEARRREEQEAREKAQ 663
++ +Q EQ REE+E+R ER+++ REE+ L +E E E E RRR+E E R+ +
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE-RQYRK 1082
Query: 664 AEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ---ERQERRKRLEEIMKRTR 720
E+ +QE Q +EE E R R+E ERQ E E+ Q++EQ E +E+R+R +E+ ++ R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR-QELERQYR 1141
Query: 721 KSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
+ E + +++Q +E PE + E ++E +Q+EE
Sbjct: 1142 EEEEVQQEEEQLLRE------EPEKRRRQELERQYREEEELQQEE 1180
Score = 81.6 bits (200), Expect = 3e-15
Identities = 49/141 (34%), Positives = 80/141 (56%), Gaps = 11/141 (7%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQA 664
E+ +Q EQ REE E+R + ER+++ REE+ ++ E + RE +RR ++ R+ +
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 665 EQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ---ERQERRKR--------LE 713
E+ +QE Q +EE E R R+E ERQ E E+ Q++EQ E QE+R++ E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 714 EIMKRTRKSEVSETKQKQDSK 734
E+ ++ RK + Q+ D K
Sbjct: 1204 ELQRQKRKQRYRDEDQRSDLK 1224
Score = 81.3 bits (199), Expect = 4e-15
Identities = 66/188 (35%), Positives = 99/188 (52%), Gaps = 27/188 (14%)
Query: 594 TDREEATRLLAE-KRRQAREQRER----EEQERRLQAERDKRMREEQLAREAEARAEREA 648
T+R E R + KR Q E+RER EE+ERR Q ER RE+QL RE E R E+
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER----REQQLRREQEERREQRL 519
Query: 649 EARRREEQEAREKAQAEQ-----EEQERLQKQKEEAEARSREEAERQRLEREKH------ 697
+ R+ EE+ +++ ++EQ +E+ R Q K E E R +E QRL+RE+
Sbjct: 520 K-RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 698 FQQQEQERQERRKR-LEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGL 756
+++E+ RQ+R KR EE +++ K E E ++++ +E PE E R L
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE-----EERRQQL 633
Query: 757 QKEAVQKE 764
K Q+E
Sbjct: 634 LKSEEQEE 641
Score = 80.1 bits (196), Expect = 8e-15
Identities = 57/154 (37%), Positives = 90/154 (58%), Gaps = 19/154 (12%)
Query: 597 EEATRLLAEKRRQAREQRE-REEQERRLQAERDKRMR---------EEQLAREAEARAER 646
E R L E+ RQ RE+ E ++E+E+ L ER+ R R EE+L +E E
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 647 EAEARRREEQE--AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ- 703
E E RRR+E+E RE+ + +QEE++ L +EE E R R+E ERQ E E+ Q++EQ
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLL---REEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 704 --ERQERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
E E+R+R +E+ ++ R+ E + +++Q +E
Sbjct: 1154 LREEPEKRRR-QELERQYREEEELQQEEEQLLRE 1186
Score = 79.7 bits (195), Expect = 1e-14
Identities = 51/156 (32%), Positives = 89/156 (57%), Gaps = 17/156 (10%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMR-EEQLAREAEARAEREA--EARRR 653
++ R E+RR+ + +RE+EE+ R Q R++++R E+QL RE + R E++ E + R
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLERE--------KHFQQQEQER 705
EQ+ R + Q +E+Q R ++++E E + +E QRL+RE K ++ E+
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 706 QERRKRL------EEIMKRTRKSEVSETKQKQDSKE 735
QERRK+ EE +R K E E +++Q+ +E
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Score = 79.7 bits (195), Expect = 1e-14
Identities = 54/176 (30%), Positives = 98/176 (55%), Gaps = 18/176 (10%)
Query: 608 RQAREQREREEQERRLQAERDKRMREEQL-AREAEARAEREAEARRREEQEAR-EKAQAE 665
R+ RE+R R+E+ER+ + ++ + +EEQL E E R +E E + REE+E + E+ Q
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 666 QEEQERLQKQKEEAEARS------------REEAERQRL-EREKHFQQQEQERQERRKRL 712
+EE+E+ ++Q+ E + R REE E++RL ERE+ ++++E+ +QE + L
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 713 EEIMKRTRKSEVSETKQKQD---SKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
E + R+ E+ +K++ +E PE + E ++E +Q+EE
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Score = 79.0 bits (193), Expect = 2e-14
Identities = 49/192 (25%), Positives = 102/192 (53%), Gaps = 15/192 (7%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLARE-----------AEAR 643
+ EE R L E++ RE++E E+Q++RL+ E+ R ++E+ RE E +
Sbjct: 273 EEEEQLRKL-ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 644 AEREAEARRREEQEAREKAQAEQEEQERLQKQ---KEEAEARSREEAERQRLEREKHFQQ 700
ER + RRE++E RE+ ++E+ER ++Q ++E E R ++ Q+L RE+ ++
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 701 QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEA 760
++Q R+E++ R E+ ++R ++ + +++ E E R L++E
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 761 VQKEEPIPQEPQ 772
++ + + +E +
Sbjct: 452 EERRDWLKREEE 463
Score = 78.6 bits (192), Expect = 2e-14
Identities = 62/208 (29%), Positives = 113/208 (54%), Gaps = 27/208 (12%)
Query: 596 REEATRLLAEKRRQAREQREREEQERR---LQAERDKRM----REEQLAREAEARAE--- 645
+EE RL ++R ++ +Q RE++ERR L+ E +KR+ RE++L RE E R +
Sbjct: 522 QEEEERL--QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 646 -REAEARR---REEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQ 701
RE E R+ + EQE R + + ++EE ERL++++ + REE E +R ++ ++Q
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 702 EQERQ-----ERRKRLEEIMKRTRKSEVSETKQKQDSKEAN-----ANGSSPEPVKAVEA 751
E+ RQ E+++R E+ +KR + E E + K++ +E A + + +++
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 752 RSPGLQKEAVQKEEPIPQEPQWSLPSKE 779
R P Q + ++ E Q +S P K+
Sbjct: 700 RIPKWQWQ-LESEADARQSKVYSRPRKQ 726
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/213 (29%), Positives = 107/213 (50%), Gaps = 30/213 (14%)
Query: 596 REEATRLLAEKRRQAREQREREEQERR---LQAERDKRMREEQLAREAEARAER------ 646
REE RL E+RR+ R +RE E+ERR L++E + R++QL RE + R E+
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663
Query: 647 -----EAEARRREEQEAREKAQAEQEEQERLQKQKE---------EAEARSREEAERQRL 692
E +R E+E RE+ AE+E+++ ++ K E+EA +R+ R
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR- 722
Query: 693 EREKHFQQQEQERQERRKRLEEIM-----KRTRKSEVSETKQKQDSKEANANGSSPEPVK 747
R++ Q++ QE++E+R+R E + +R + + E +++ + + A S +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 748 AVEARSP-GLQKEAVQKEEPIPQEPQWSLPSKE 779
+ AR P Q+E + E Q Q LP +E
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Score = 77.8 bits (190), Expect = 4e-14
Identities = 51/177 (28%), Positives = 98/177 (55%), Gaps = 7/177 (3%)
Query: 603 LAEKRRQAREQREREEQERRLQAERDK--RMREEQLAREAEARAEREAEARRREEQEARE 660
L K R+ ++Q+ RE Q+R Q E +K R RE L +E E E E + +R ++E +
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277
Query: 661 KAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ--ERQERRKRLEEIMKR 718
+ E++E R ++++E+ + R R E + +R + E+ +QQE+ E+QERR++ EE ++
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 719 TRKSEVSETKQKQDSKEANANGSSPE--PVKAVEARSPGLQKE-AVQKEEPIPQEPQ 772
+ E E +++Q +E + + E R L++E +++E+ + +E Q
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Score = 77.0 bits (188), Expect = 7e-14
Identities = 51/178 (28%), Positives = 97/178 (54%), Gaps = 9/178 (5%)
Query: 595 DREEATRLLAEKRRQAREQREREEQE--RRLQAERDKRM-REEQLAREAEARAEREAEAR 651
+ E + L +++ REQ+ R EQ+ R Q R++++ RE+QL RE + R RE + R
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR--REQQLR 426
Query: 652 RREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQ----QEQERQE 707
R +E+E E+ ++ ++RL++++EE + E E +R E+E+ QQ QE+ER+E
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 708 RRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
R +LEE +R ++ + +++ + E + ++ R Q+ ++EE
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Score = 76.6 bits (187), Expect = 9e-14
Identities = 92/399 (23%), Positives = 164/399 (41%), Gaps = 63/399 (15%)
Query: 384 PAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSAL-----ARERSLK 438
P + G+RR+ RRR Q++E+ ++++ E+++ A E+S +
Sbjct: 723 PRKQEGQRRRQE---QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 439 KRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPR 498
RQ L A P R + + LP + +
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQ--------------------RFLPEEEEKEQ 819
Query: 499 GTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPP 558
R R++ E ++ E++ Q + RA +E S
Sbjct: 820 --------RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 559 QKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREE 618
QK + E T PA K + EE E +R+ RE+R R+E
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE------ELQREEREKRRRQE 925
Query: 619 QERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERL-----Q 673
QER+ + E + EEQL RE ERE R+ E++ R+ + +Q+E++ L +
Sbjct: 926 QERQYREEEQLQQEEEQLLRE-----EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 674 KQKEEAEARSREEAERQ-------RLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSE 726
++++E E + REE E Q R EREK ++QE ERQ R+K + +++ + + E
Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKR-RRQEWERQYRKK---DELQQEEEQLLRE 1036
Query: 727 TKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
++K+ +E E ++ E + G ++E +++E
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Score = 76.3 bits (186), Expect = 1e-13
Identities = 52/149 (34%), Positives = 84/149 (56%), Gaps = 14/149 (9%)
Query: 597 EEATRLLAEKRRQAREQ----REREEQERRLQAERDKRMREE--QLAREAEARAEREAEA 650
EE +L E+ R+ RE+ +EREEQ+ Q ERD++ EE QL R+ R RE E
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQ-ERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 651 RRREEQEAREKAQAEQEEQERLQKQK----EEAEARSREEAERQRLEREKHFQQQEQERQ 706
R QE K E+++ R Q+Q+ EE + R +E +++R +R++ F+++EQ RQ
Sbjct: 1509 R---SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 707 ERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
ER ++ +R RK + E K ++ +E
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Score = 75.9 bits (185), Expect = 1e-13
Identities = 47/147 (31%), Positives = 87/147 (59%), Gaps = 14/147 (9%)
Query: 597 EEATRLLAEKRRQAREQRE-REEQERRLQAERDKRMREE---QLAREAEARAEREAEARR 652
E R E+ RQ RE+ E ++E+E+ L+ ER+KR R+E Q E E + E E R
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 653 REEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ-ERQERRKR 711
E+ R++ + + E+E LQ+++E+ REE E++R ERE+ ++++E+ +RQ+R++R
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQL---LREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 712 LEEIMKRTRKSEVSETKQKQDSKEANA 738
+ + + S+ K + + ++ NA
Sbjct: 1214 YRD------EDQRSDLKWQWEPEKENA 1234
Score = 74.3 bits (181), Expect = 4e-13
Identities = 61/188 (32%), Positives = 101/188 (53%), Gaps = 28/188 (14%)
Query: 605 EKRRQAREQREREEQERR------LQAERDKRMREE---------QLAREAEARAEREAE 649
++RRQ RE++ REE+E + L+ ER+KR R+E +L +E E E E
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 650 ARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ---ERQ 706
RR +E+E R+ + E+ +QE Q EE E R R+E ERQ + E+ Q++EQ E
Sbjct: 1040 KRRLQERE-RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 707 ERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEP 766
E+R+R +E ++ R+ E + +++Q +E E + E ++E VQ+EE
Sbjct: 1099 EKRRR-QERERQCREEEELQQEEEQLLREER------EKRRRQELERQYREEEEVQQEEE 1151
Query: 767 --IPQEPQ 772
+ +EP+
Sbjct: 1152 QLLREEPE 1159
Score = 73.6 bits (179), Expect = 7e-13
Identities = 52/156 (33%), Positives = 85/156 (54%), Gaps = 26/156 (16%)
Query: 605 EKRRQAREQREREEQ-ERRLQAERDKRMREEQLAREAEARAEREAEARRR----EEQEAR 659
E+RRQ R +RE+EE+ E+RL+ E +R+ +E+ + R E E E R++ EEQE R
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 660 EKAQAEQEEQER----LQKQKEE--AEARSREEAERQRLEREKHFQQQEQERQERRKRL- 712
+ Q +E+QER L++++EE E R + E E +R E+E ++QEQ R+ + R+
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 713 --------------EEIMKRTRKSEVSETKQKQDSK 734
++ R RK E +Q+Q+ K
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Score = 73.2 bits (178), Expect = 1e-12
Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 30/214 (14%)
Query: 596 REEATRLLAEKRRQAREQR-----EREEQERRLQAERDKRM----------REEQLAREA 640
RE+ R + RR+ E+R E+E +E+RL+ E+++R R EQ R+
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 641 EARAEREAEARRR----EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER--QRLER 694
+ + ++E E R R EE+E RE+ + +++ R Q+++ E + +EE ER QRL
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 695 EKHFQQQEQERQER------RKRLEEIMKRTRKSEVSETKQKQ---DSKEANANGSSPEP 745
E+ +++++ER+E+ KRLE+ + R E ++ Q +E E
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 746 VKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKE 779
+ +E R + E +++EE Q + P +E
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Score = 72.8 bits (177), Expect = 1e-12
Identities = 53/199 (26%), Positives = 108/199 (54%), Gaps = 16/199 (8%)
Query: 596 REEATRLLAEKRRQAREQRE----REEQERRLQAERDKRMREEQLAREAEARAE---REA 648
RE+ R + RR+ + +RE RE++E R + + ++ RE++L RE E R + RE
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE 462
Query: 649 EARRREEQEAREKAQAEQEEQERLQKQK-EEAEARSREEAERQRLEREKHFQQQEQ-ERQ 706
E R E++ +++ + +QEE+ R + K EE E R ++E Q+L RE+ +++++ +RQ
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 707 ERRKRLEEIMK-----RTRKSEVSETKQKQDSKEANANGSSPEPVK--AVEARSPGLQKE 759
E +RL++ ++ R + E E K++ ++ + +K E R L++E
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 760 AVQKEEPIPQEPQWSLPSK 778
++++ + +E + L +
Sbjct: 583 EERRQQRLKREQEERLEQR 601
Score = 72.4 bits (176), Expect = 2e-12
Identities = 59/173 (34%), Positives = 90/173 (52%), Gaps = 27/173 (15%)
Query: 588 KPMAGTTDREEATRLLAEKRRQAREQ--REREEQERRLQAERDKRMREE--QLAREAEAR 643
+P +RE+ R +++ + EQ +E EEQ+ R Q ERD++ REE QL R+ R
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ-ERDRKFREEEQQLRRQERER 1707
Query: 644 A---------EREAEARRREEQEAREKAQAEQ-EEQERLQKQKEEAEAR-SREEAERQRL 692
+E E + REE++ R++ + EQ QER +K EE + R REE + +R
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ 1767
Query: 693 EREKHFQQQEQERQER-----------RKRLEEIMKRTRKSEVSETKQKQDSK 734
ER++ F+++EQ RQER RK EE R + E Q++D K
Sbjct: 1768 ERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820
Score = 71.6 bits (174), Expect = 3e-12
Identities = 48/183 (26%), Positives = 96/183 (52%), Gaps = 19/183 (10%)
Query: 596 REEATRLLAEKRRQAREQRER--EEQERRLQAERDKRMREEQLAREAEARAEREAEARRR 653
RE R+ E+ + +RE ++E +LQ E +R RE Q E E + R+
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ---------EEEEQLRKL 281
Query: 654 EEQEAREKAQAEQEEQERLQKQKE---EAEARSREEAERQRLEREKHFQQQEQERQERRK 710
E QE R + Q E+++Q+RL+++++ + E RE+ E +R ++E+ QQ+E+ Q+ R+
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKE-AVQKEEPIPQ 769
EE ++ + E E +++Q + + ++ R L++E +++E+ + +
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLR----REQQLRREQQLRREQQLRR 397
Query: 770 EPQ 772
E Q
Sbjct: 398 EQQ 400
Score = 71.2 bits (173), Expect = 4e-12
Identities = 49/187 (26%), Positives = 93/187 (49%), Gaps = 11/187 (5%)
Query: 594 TDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRR 653
T +E R + + + R +EE +RR + RD+++ EE R + R E+E E
Sbjct: 93 TGLDEEKRARCDGKESLLQDRRQEEDQRRFE-PRDRQLEEEPGQRRRQKRQEQERELAEG 151
Query: 654 EEQEAREKAQAEQEEQ---ERLQKQKEEAEARSREEAERQRLEREKHFQQQE--QERQER 708
EEQ +++ +++ Q E L +Q++E + R AE ++L+ K + +E E Q R
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211
Query: 709 RKRLEEIMKRTRKSEVSETKQKQD---SKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
R+ L E+ ++ R+ + + +++QD +E E V E LQ+E Q++
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK--LQEEEPQRQR 269
Query: 766 PIPQEPQ 772
+ +E +
Sbjct: 270 ELQEEEE 276
Score = 71.2 bits (173), Expect = 4e-12
Identities = 52/163 (31%), Positives = 93/163 (57%), Gaps = 17/163 (10%)
Query: 595 DREEATRLLAEKRRQAREQ----REREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
+REE E+ R+ RE+ +EREEQ+ R Q E D++ REE+ R + R E++
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ-ESDRKFREEEQLR--QEREEQQLRP 1814
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREE---AERQRLEREKHFQQQEQE-RQ 706
++R+ + E+ Q + EEQE+ +Q+ + + R+ E+ E+ R E ++ +Q++EQ+ RQ
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ 1874
Query: 707 ERRKRLEEIMKRTRKSEVSETKQKQ----DSKEANANGSSPEP 745
ER ++L E + R+ + E + +Q S+E +G EP
Sbjct: 1875 ERERKLRE--EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Score = 70.5 bits (171), Expect = 6e-12
Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 25/196 (12%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREA------- 648
R+E R LAE Q+ +Q E+++R+ + E R R+E RE E RAE E
Sbjct: 141 RQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE-ERRAEEEQLQSCKGH 199
Query: 649 ---------EARRREEQEAR-----EKAQAEQEEQERLQKQKEEAEARSREEAERQRLER 694
+ RRRE E R EK Q +E Q+R+ +++EE E R RE R +
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR---KE 256
Query: 695 EKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSP 754
E+ Q++E +RQ + EE +++ + E+ +Q+++ ++ K E R
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 755 GLQKEAVQKEEPIPQE 770
++ Q+E QE
Sbjct: 317 QQEERREQQERREQQE 332
Score = 70.1 bits (170), Expect = 8e-12
Identities = 55/191 (28%), Positives = 98/191 (51%), Gaps = 20/191 (10%)
Query: 595 DREEATRLLAEKRRQAREQR---EREEQERRLQAERDKRMREEQLAREAEARAEREAEAR 651
+REE R R+ E++ EREEQ R Q ERD++ REE+L + + R E E R
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQ-ERDRKFREEELRHQEQGRKFLEEEQR 1382
Query: 652 RR----------EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQ 701
R EEQ+ R + + +Q Q+R +K +EE + SR+E +R+ E E+ ++Q
Sbjct: 1383 LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 702 EQER----QERRKRLEEIMKRTRKSEVSETKQKQD--SKEANANGSSPEPVKAVEARSPG 755
E+ER +E++ R E K + ++ + +++Q +E + E + R
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 756 LQKEAVQKEEP 766
+++ ++ +EP
Sbjct: 1503 FREQELRSQEP 1513
Score = 69.3 bits (168), Expect = 1e-11
Identities = 43/126 (34%), Positives = 73/126 (57%), Gaps = 3/126 (2%)
Query: 612 EQRERE-EQERRLQAERDKRM-REEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQ 669
EQ+ER+ EQERR +RD+ EEQL RE + A+R + E+Q RE+ + ++ Q
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 670 ERLQKQKEEAEA-RSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETK 728
E +K +EE + + REE +R ER++ F+++E QE+ ++ E +R R+ E
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF 1392
Query: 729 QKQDSK 734
K++ +
Sbjct: 1393 LKEEQQ 1398
Score = 69.3 bits (168), Expect = 1e-11
Identities = 46/150 (30%), Positives = 82/150 (54%), Gaps = 12/150 (8%)
Query: 586 PSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAE 645
P + +++EA R + + + + RE E++RR Q K EEQL +E E +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 646 REAEARRR-EEQEAREKAQAEQ--EEQERLQKQ-------KEEAEARSREEAERQRLERE 695
R E R+ E+E R + Q + EE++RL++Q KEE + R +E ++ R +R+
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 696 KHFQQQEQE--RQERRKRLEEIMKRTRKSE 723
+ F+++EQ+ RQER ++ E ++ R+ E
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQE 1443
Score = 69.3 bits (168), Expect = 1e-11
Identities = 52/144 (36%), Positives = 79/144 (54%), Gaps = 14/144 (9%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMR-EEQLAREAEARAEREAEARRRE 654
R+E R E+ Q R R+E+E++L+ +RD++ R EEQL +E E E + RR+E
Sbjct: 1638 RQERDRKFLEEEPQLR----RQEREQQLRHDRDRKFREEEQLLQEGE-----EQQLRRQE 1688
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQE---RQER-RK 710
+ + + QER +K +E + R+E ER+ E E+ Q+ EQE RQER RK
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1748
Query: 711 RLEEIMKRTRKSEVSETKQKQDSK 734
LEE R + E +Q++D K
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRK 1772
Score = 68.9 bits (167), Expect = 2e-11
Identities = 45/165 (27%), Positives = 88/165 (53%), Gaps = 24/165 (14%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQA----ERDKRMREEQLAREA------EARA 644
DR+ L +R++ +E+ ER +E +LQ+ E ++ EEQL R + R
Sbjct: 165 DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE 224
Query: 645 EREAEARRR--------EEQEAREKAQAEQEEQERLQKQKEEAEARSREE------AERQ 690
E++ + R R EE+E R++ ++E+E+LQ+++ + + +EE ERQ
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 691 RLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
L RE+ ++Q+Q+R R ++L + R+ + E +++Q+ +E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/182 (25%), Positives = 94/182 (51%), Gaps = 5/182 (2%)
Query: 596 REEATRLLAEKRRQAREQRERE-EQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
RE+ R + RR+ + +RE++ +E++L+ E+ R +E+ E + ER + +RE
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450
Query: 655 EQEAREKAQAEQE----EQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK 710
++E R+ + E+E EQER ++Q + + R E + E E+ QQ+ +E+Q RR+
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510
Query: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
+ E +R ++ E E Q++ E E + + R + E ++E+ + +E
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 771 PQ 772
+
Sbjct: 571 QE 572
Score = 68.6 bits (166), Expect = 2e-11
Identities = 54/187 (28%), Positives = 93/187 (49%), Gaps = 13/187 (6%)
Query: 596 REEATRLLAEKRRQAREQRER---EEQERRLQAERDKRMREEQ----LAREAEARAEREA 648
R+E R E+ + +EQ + EEQ R Q K ++EEQ RE + R +R+
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 649 EARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQER 708
+ R E+Q +R++ + E+E+ Q +++E E + EE ++ R ER + F+++EQ QER
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQ-QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 709 RKRLEEIMKRTRK---SEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
++ +R RK E +Q++D K S EP + L ++ Q++
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ--QRQR 1531
Query: 766 PIPQEPQ 772
QE Q
Sbjct: 1532 KFLQEEQ 1538
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/187 (31%), Positives = 95/187 (50%), Gaps = 13/187 (6%)
Query: 596 REEATRLLAEKRRQAREQ-RER-----EEQERRLQAERDKRMREEQLAREAEARAEREAE 649
R+E R E+ +Q R Q RER E+Q RR + ER K EEQL +E E R E
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER-KFREEEQLRQETEQEQLRRQE 1744
Query: 650 ARRR---EEQEAREKAQAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKHFQQQEQER 705
R+ EEQ E+ + + QER +K +EE + R REE + + E ++ F+++EQ R
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 706 QERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
QER ++ +R K E + + + +E +A E + Q+++ ++E+
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFA--TQEKSRREEQ 1862
Query: 766 PIPQEPQ 772
+ QE +
Sbjct: 1863 ELWQEEE 1869
Score = 67.4 bits (163), Expect = 5e-11
Identities = 51/177 (28%), Positives = 90/177 (50%), Gaps = 32/177 (18%)
Query: 596 REEATRLLAEKRRQAREQRER-----------EEQERRLQAERDKRMREE--QLAREAEA 642
+E+ + L E++R R++RER +E+E++L+ +RD++ REE QL+R+
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429
Query: 643 RAEREAEARRREEQEAREKAQAEQ-----------EEQERLQKQKEEAEARS-------R 684
R RE E + R ++ R+ + EQ EE++ LQ+++E+ R
Sbjct: 1430 RKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE 1489
Query: 685 EEAERQRLEREKHFQQQEQERQE-RRKRLEEIMKRTRKSEVSETKQKQDSKEANANG 740
EE + +R ER++ F++QE QE RK LEE + R+ + Q++ G
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Score = 66.6 bits (161), Expect = 9e-11
Identities = 47/183 (25%), Positives = 94/183 (51%), Gaps = 16/183 (8%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAE----- 649
+ E+ R EKRRQ RE++ REE+E + Q +R +R R+E + + + E E E
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQ-KRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Query: 650 ----ARRREEQEAREKAQA---EQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQE 702
+ RE ++ R+ + +++ Q+ LQ E + R RE+ R+ +R++HF ++E
Sbjct: 1238 NKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297
Query: 703 QERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQ 762
Q +E +K E +R RKS+ + +++ +E + + E +++ ++
Sbjct: 1298 QLEREEQK---EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 763 KEE 765
++E
Sbjct: 1355 RQE 1357
Score = 66.6 bits (161), Expect = 9e-11
Identities = 51/155 (32%), Positives = 88/155 (56%), Gaps = 24/155 (15%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMRE-EQLAREAEARA---------- 644
R+E R E +Q R R+E +++L+ ERD++ RE EQL +E E +
Sbjct: 1590 RQEQERKFMEDEQQLR----RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 645 -EREAEARRRE-EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQE 702
E E + RR+E EQ+ R + E+E+L ++ EE + R R+E +R+ E E+ ++QE
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR-RQERDRKFREEEQQLRRQE 1704
Query: 703 QER----QERRKRLEEIMKRTRKSEV--SETKQKQ 731
+ER +E++ R +E+ ++ R+ E ET+Q+Q
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/176 (25%), Positives = 94/176 (53%), Gaps = 13/176 (7%)
Query: 606 KRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQE-------A 658
+RR+ E R + +E++ Q +R R++++ +E E + R+ E R+E+E
Sbjct: 211 RRRELLELRRKGREEKQQQ----RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 659 REKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHF--QQQEQERQERRKRLEEIM 716
R++ E+EEQ R +++E R EE ++QRL RE+ +Q+E+ R+++ +R E+
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 717 KRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
+R ++ E E + +++ +E E + + ++E ++E+ + +E Q
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Score = 66.2 bits (160), Expect = 1e-10
Identities = 45/147 (30%), Positives = 81/147 (55%), Gaps = 14/147 (9%)
Query: 596 REEATRLLAEK----RRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEAR 651
R+E R E+ RRQ R+++ RE++ R + ER E+QL R+ R +
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ---- 1535
Query: 652 RREEQEAREKAQAEQEEQERLQKQKEEAEAR-SREEAERQRLEREKHFQQQEQE---RQE 707
EEQ+ R + + +Q Q+R +K +EE + R REE + R ER++ F+ +EQ+ +++
Sbjct: 1536 --EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 708 RRKRLEEIMKRTRKSEVSETKQKQDSK 734
RK +E+ + R+ + +Q++D K
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Score = 65.1 bits (157), Expect = 3e-10
Identities = 43/181 (23%), Positives = 93/181 (51%), Gaps = 10/181 (5%)
Query: 597 EEATRLLAEKRRQAREQREREEQ-----ERRLQAERDKRMREEQLAREAEARAEREAEAR 651
E + L ++++ REQR + E+ E+RL+ E ++ RE++LA E + +A ++R
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 652 RREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKR 711
+ Q E ++A+ + + + +++ R R+E E +R RE Q QE+ER R+++
Sbjct: 701 IPKWQWQLE-SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Query: 712 LEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771
EE R+ + + ++ S+ S+ P++ R ++ +++ +P+E
Sbjct: 760 EEE----QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Query: 772 Q 772
+
Sbjct: 816 E 816
Score = 64.7 bits (156), Expect = 3e-10
Identities = 46/149 (30%), Positives = 84/149 (56%), Gaps = 11/149 (7%)
Query: 597 EEATRLLAEKRRQAREQRER----EEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
EE R E+++ +R++R+R EEQ+ R Q + K M +EQ R E + + E R
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 653 R---EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQ-RLEREKHFQQQE---QER 705
+ +EQ +E+ + + QER +K EE R+E E+Q R +R++ F+++E QE
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679
Query: 706 QERRKRLEEIMKRTRKSEVSETKQKQDSK 734
+E++ R +E ++ R+ E +Q+++ K
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERK 1708
Score = 64.3 bits (155), Expect = 4e-10
Identities = 52/155 (33%), Positives = 83/155 (53%), Gaps = 16/155 (10%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREE-QLAREAEARAEREAEARRR 653
DRE+ R ++ R E+ + E +E++ RD++ +EE QL RE R E R+
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337
Query: 654 ---EEQEAREKAQAEQEEQERLQKQKEEAEARSREEA-----ERQRL---EREKHFQQQE 702
EEQ +E+ + QER +K +EE E R +E+ E QRL ERE+ F ++E
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREE-ELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 703 QER--QERRKRLEEIMKRT-RKSEVSETKQKQDSK 734
Q+ QER ++L + R R+ E ++Q++D K
Sbjct: 1397 QQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Score = 64.3 bits (155), Expect = 4e-10
Identities = 61/212 (28%), Positives = 103/212 (48%), Gaps = 15/212 (7%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA--RRR 653
REE +L ++R R+ RE E+Q RR + ER K + EEQ R+ R RE E + R
Sbjct: 1417 REEEQQLSRQERD--RKFREEEQQVRRQERER-KFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 654 EEQEA--REKAQAEQEEQERLQKQKEEAEARSRE----EAERQRLEREKHFQQQEQERQE 707
EEQ+ +E+ + EE+++L++Q+ + + R +E E ER+ LE E QQ +Q
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE----QQLHRQQR 1529
Query: 708 RRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPI 767
+RK L+E + R+ + +Q +D K E + +R +K +++++
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVR 1589
Query: 768 PQEPQWSLPSKELPASLVNGLQPLPAHQENGF 799
QE + E G Q L ++ F
Sbjct: 1590 RQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Score = 63.9 bits (154), Expect = 6e-10
Identities = 58/236 (24%), Positives = 111/236 (47%), Gaps = 56/236 (23%)
Query: 596 REEATRLLAEKRRQAREQREREEQ--ERRLQAERDKRMREEQLAREAEARA--------- 644
R++ R ++RR+ R +RE EE+ E+RL+ E ++ RE++LA E + +A
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Query: 645 ------EREAEAR---------RREEQEARE---------KAQAEQEEQERLQKQKEEAE 680
E EA+AR ++E Q R+ +++ + +E+ER +Q++E E
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 681 ----------ARSREEAERQRL--------EREKHFQQQEQERQERRKRLEEIMKRTRKS 722
A + E RQRL +RE+ + +E++++E+R EE K R+
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 723 EVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQK---EEPIPQEPQWSL 775
+ E +++ E E + ++ GLQ++ ++ E+ Q+ +W L
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Score = 63.9 bits (154), Expect = 6e-10
Identities = 47/168 (27%), Positives = 86/168 (51%), Gaps = 30/168 (17%)
Query: 598 EATRLLAEKRRQAREQRER-----EEQERRLQAERDKRMREEQLAR--------EAEARA 644
E +LL E+ Q ++ER EE+++ + ERD++ RE++L E E +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 645 EREAEARR--REEQEAREKAQAEQEEQERLQKQKEEAEARS-REEAERQRLEREKHFQQQ 701
R+ R+ +EEQ+ R + + +Q Q+R +K +EE + R REE + R ER++ F+ +
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584
Query: 702 EQ--------------ERQERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
EQ E+Q RR+ ++ +++ R + E +Q +E
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Score = 63.9 bits (154), Expect = 6e-10
Identities = 43/149 (28%), Positives = 82/149 (55%), Gaps = 10/149 (6%)
Query: 596 REEATRLLAEKRRQAREQRER----EEQERRLQAERDKRM--REEQLAREAEARAEREAE 649
+E + L E+++ R+QR+R EEQ+ R Q +R R+ + E + R ERE +
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 650 ARRREEQEAR---EKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQ 706
R+E++ + E+ + ++EQER + ++E + R +E ++ R ER++ F++ EQ Q
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQER-KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Query: 707 ERRKRLEEIMKRTRKSEVSETKQKQDSKE 735
ER ++ +R RK E + ++ +E
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Score = 62.8 bits (151), Expect = 1e-09
Identities = 47/179 (26%), Positives = 92/179 (51%), Gaps = 14/179 (7%)
Query: 605 EKRRQAREQREREEQERRLQAE--------RDKRMR-EEQLAREAEARA---EREAEARR 652
++RRQ R+++ REE++ R + E RD++ R EEQ R E E E + RR
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606
Query: 653 RE-EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKR 711
+E +Q+ R++ + E E+L +++EE + R+E +R+ LE E ++QE+E+Q R R
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLH-RQERDRKFLEEEPQLRRQEREQQLRHDR 1665
Query: 712 LEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
+ + + + E +Q + + + ++ E LQ+E + + + ++
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724
Score = 61.2 bits (147), Expect = 4e-09
Identities = 51/223 (22%), Positives = 101/223 (45%), Gaps = 40/223 (17%)
Query: 596 REEATRLLAEKR--RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRR 653
R+E R E+ +Q EQ REE E+R + E +++ REE+ ++ E + RE + +RR
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAE----------------------ARSREEAERQR 691
+E+E + + + E + Q+R Q+ ++E + + RE + ++
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 692 LE----REKHFQQ---------QEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANA 738
LE R++ QQ QE++R++ R+R ++ R R E ++++ KEA
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ---RDRHFPEEEQLEREEQKEAKR 1309
Query: 739 NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELP 781
+ K + ++ + + +E Q +E P
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Score = 60.5 bits (145), Expect = 6e-09
Identities = 54/197 (27%), Positives = 96/197 (48%), Gaps = 23/197 (11%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREA-EARAEREAEARRR 653
+ EE + + R+ RE+R R+E ER+ + E + + EEQL RE E R +E E + R
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 654 EEQEAR-----------EKAQAEQE----EQERLQKQKEEAEARSREEAERQRLEREKHF 698
EE+E + EK + E+E E+E LQ+QK + R R+E +R L+ +
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR--KQRYRDEDQRSDLKWQWEP 1229
Query: 699 QQQEQERQER---RKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPG 755
+++ R + + R E ++ S++ + + +QD + + G E + E R
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ--HLLGEQQERDREQERRRWQ 1287
Query: 756 LQKEAVQKEEPIPQEPQ 772
+ +EE + +E Q
Sbjct: 1288 QRDRHFPEEEQLEREEQ 1304
Score = 59.7 bits (143), Expect = 1e-08
Identities = 44/136 (32%), Positives = 74/136 (54%), Gaps = 15/136 (11%)
Query: 607 RRQAREQREREEQERRLQAERDKRMR--EEQLAREAEARAER--EAEARRRE-------- 654
RRQ R Q+ R++++R+ + E R E+QL+R+ R R E + RR+E
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEA-RSREEAERQRLEREKHFQQQEQERQERRKRLE 713
EQ+ R + +Q QER +K +E+ + + REE + R ER++ F E+E Q RR+ E
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF--LEEEPQLRRQERE 1658
Query: 714 EIMKRTRKSEVSETKQ 729
+ ++ R + E +Q
Sbjct: 1659 QQLRHDRDRKFREEEQ 1674
Score = 54.3 bits (129), Expect = 5e-07
Identities = 48/182 (26%), Positives = 83/182 (45%), Gaps = 41/182 (22%)
Query: 595 DREEATRLLAEKRRQAREQREREEQER----------RLQAERDKRM----REEQLAREA 640
+RE R E +RQ R+QR R+E +R + A RD ++ RE + R+
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 641 E------------------ARAEREAEARRREEQEA----REKAQAEQEEQERLQK---- 674
E + ER+ E RR Q+ E+ Q E+EEQ+ ++
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 675 -QKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDS 733
Q+E+ R E +R+R E ++ F+++EQ QER ++ +R RK E + ++
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373
Query: 734 KE 735
++
Sbjct: 1374 RK 1375
Score = 50.1 bits (118), Expect = 9e-06
Identities = 36/114 (31%), Positives = 65/114 (57%), Gaps = 13/114 (11%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEE------KAKALREKQLQERRRRL 182
++++ K E +L +ERRE+R K ++ L K E + K +E++L++R +R
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE 605
Query: 183 EEQRLKAEQRRAAL------EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E +RL+ E+RR EE +RQ+L K++E+ E Q+ +++ E R+QR
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR-QQQLRREQQERREQR 658
Score = 48.5 bits (114), Expect = 3e-05
Identities = 34/109 (31%), Positives = 64/109 (58%), Gaps = 12/109 (11%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKA-KALREKQLQERRRRLEEQR- 186
+QE ++ ++H+ +ERRE+R K ++ WL++EE+ + +E++ Q+ +R EE+R
Sbjct: 428 EQEEERHEQKHE--QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 187 -----LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
L+ E+RR E R++Q + +ER E ++R ++ E QQR
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE---ERLQQR 531
Score = 45.8 bits (107), Expect = 2e-04
Identities = 29/102 (28%), Positives = 55/102 (53%), Gaps = 9/102 (8%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E + ER +L +ER+EE + ++ + + LR KQ +ERR + EE+R +
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQ---------QRLRREQQLRRKQEEERREQQEERREQ 324
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E+R E R++Q + +ER E ++R ++ E + +R
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAK--KAVWLEKEEKAKALREKQLQERRRRLEEQR 186
+Q +K+ +ERRE+R K + + L K E+ + R++QL+ ++ EQR
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 187 LKAEQRRAALEER-QRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSW 233
LK E+ LE+R +R+ E+ +E+ A ++ + + R +W W
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/106 (28%), Positives = 58/106 (54%), Gaps = 6/106 (5%)
Query: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKA 189
QE ++ +R + K RR+E+ + ++ + E+E+ + REK+ ++ R R + K
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 190 EQRRAAL-----EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+Q+ L E+R+RQ+ EK K R E +Q+ ++ E R++R
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREK-KYREEEELQQEEEQLLREEREKR 1011
Score = 43.5 bits (101), Expect = 8e-04
Identities = 26/104 (25%), Positives = 59/104 (56%), Gaps = 2/104 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVW--LEKEEKAKALREKQLQERRRRLEEQR 186
+Q+ ++ + + +ERRE+R K ++ + L E++ + +E++ ++ +R EE+R
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
L+ E+R L+ Q ++ ++ +R E Q+ +K+ E +QR
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/98 (24%), Positives = 50/98 (51%), Gaps = 4/98 (4%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAK----ALREKQLQERRRRLEEQRLKAEQR 192
ERH+ + +++ + ++ WL+ EE+ + RE+QL+ + EQRLK ++
Sbjct: 465 ERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE 524
Query: 193 RAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
L++R R + + +E+ E Q ++ + Q+R
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/109 (27%), Positives = 63/109 (57%), Gaps = 10/109 (9%)
Query: 130 QEVKKAGERH--KLAKERREERAKYLAAKKAVWLEKEEKA--KALREKQLQERRRRL--- 182
Q +K+ ER +L +E+ E + L ++ LE+EE+ + RE+ +ERR++L
Sbjct: 577 QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 183 -EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E++ + +Q R +ER+ Q+L++ +E E +++ +K+ E R+++
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEE--EERLEQRLKREHEEERREQ 683
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 27/115 (23%)
Query: 123 SDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL 182
S PP +++ ER A+ER++ ++L EE+ K R +Q +ER + L
Sbjct: 785 SARPPLREQ----RERQLRAEERQQREQRFLP---------EEEEKEQRRRQRREREKEL 831
Query: 183 ----EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSW 233
EE++L+ +R L+E + L++++ER + QR R Q+W W
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEE-DGLQEDQERRRSQEQR---------RDQKWRW 876
Score = 40.4 bits (93), Expect = 0.007
Identities = 29/104 (27%), Positives = 57/104 (54%), Gaps = 10/104 (9%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ--R 186
K+E K E + +E +EE + LE++E + +E++ Q++R R E+Q R
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRK------LERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ E+RR EER+ Q ++ +E+ E ++ +++ E R+Q+
Sbjct: 309 KQEEERREQQEERREQ--QERREQQEERREQQLRREQEERREQQ 350
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/85 (30%), Positives = 49/85 (57%), Gaps = 5/85 (5%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKEEKAKALR----EKQLQERRRRLEEQRLKAEQRR 193
R K +ERRE++ + ++ ++E + + LR E++ Q+ RR EE+R + + RR
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 194 AALEERQRQKLEKNKE-RYEAAIQR 217
EER+ Q+L + ++ R E ++R
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRR 391
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/87 (32%), Positives = 47/87 (54%), Gaps = 18/87 (20%)
Query: 133 KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQR 192
K+ ER + +ERRE++ E+ E+ + RE+QL+ + EQ+L+ EQ
Sbjct: 309 KQEEERREQQEERREQQ------------ERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 193 RAALEERQRQKL--EKNKERYEAAIQR 217
EER+ Q+L E+ +ER E ++R
Sbjct: 357 ----EERREQQLRREQEEERREQQLRR 379
Score = 39.7 bits (91), Expect = 0.012
Identities = 33/116 (28%), Positives = 63/116 (54%), Gaps = 16/116 (13%)
Query: 124 DSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE 183
D ++E + GE + K RR+ER K ++ + E+E+ LRE++ E+RRR E
Sbjct: 963 DKKLQQKEEQLLGEEPE--KRRRQEREKKYREEEELQQEEEQ---LLREER--EKRRRQE 1015
Query: 184 EQR-------LKAEQRRAALEERQRQKLEKNKERY--EAAIQRSVKKTWAEIRQQR 230
+R L+ E+ + EER++++L++ + +Y E +Q+ ++ E R+ R
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Score = 39.7 bits (91), Expect = 0.012
Identities = 32/98 (32%), Positives = 55/98 (56%), Gaps = 6/98 (6%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQ-LQERRRRL-EEQRLKAEQRRAA 195
R + K RR+E + K + E+E+ + REK+ LQER R+ EE+ L+ E+ +
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 196 LEERQ---RQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
EER+ RQ+LE+ + R E +Q+ ++ E ++R
Sbjct: 1065 GEERETRRRQELER-QYRKEEELQQEEEQLLREEPEKR 1101
Score = 39.7 bits (91), Expect = 0.012
Identities = 32/119 (26%), Positives = 61/119 (51%), Gaps = 16/119 (13%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEK--EEKAKALREKQLQERRRR----- 181
++E + E +L +E RE+R + ++ E+ +E+ + LRE+ E+RRR
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP--EKRRRQELER 1168
Query: 182 --LEEQRLKAEQRRAALEERQRQKLEKNKE-RYEAAIQRSVKKTWAEIRQQR----WSW 233
EE+ L+ E+ + EE+++++ E+ ++ R E +QR +K QR W W
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Score = 38.5 bits (88), Expect = 0.026
Identities = 28/105 (26%), Positives = 55/105 (52%), Gaps = 4/105 (3%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE---Q 185
++E +K + + + EE+ + ++ L++EE+ E+Q R R+ EE Q
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 186 RLKAEQR-RAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
RL+ EQ+ R EE +R++ E+ +E+ E Q+ ++ R+Q
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Score = 38.5 bits (88), Expect = 0.026
Identities = 25/103 (24%), Positives = 55/103 (53%), Gaps = 6/103 (5%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E ++ +L +E++ R + L ++ L +E++ + RE+QL+ ++ EQ+L+
Sbjct: 365 RREQEEERREQQLRREQQLRREQQLRREQQ--LRREQQLR--REQQLRREQQLRREQQLR 420
Query: 189 AEQ--RRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
EQ RR EER QK E+ + ++ ++ W + ++
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Score = 38.5 bits (88), Expect = 0.026
Identities = 29/98 (29%), Positives = 57/98 (58%), Gaps = 6/98 (6%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQ---ERRRRLEEQRLKAEQR-- 192
R + K RR+ER + ++ + E+E+ + REK+ + ER+ R EE+ + E++
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 193 RAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
R E+R+RQ+LE+ + R E +Q+ ++ E +++R
Sbjct: 1155 REEPEKRRRQELER-QYREEEELQQEEEQLLREEQEKR 1191
Score = 38.1 bits (87), Expect = 0.034
Identities = 29/98 (29%), Positives = 51/98 (52%), Gaps = 10/98 (10%)
Query: 140 KLAKERREERAKYLAAKKAVWLEKEEKAKAL------REKQLQERRRRLEEQRLKAEQRR 193
+L +E+ E R + L ++ LE+E + + L R QL +R +QRLK EQ
Sbjct: 537 QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 194 AALEERQRQKLEK--NKERYEAAIQRSVKKTWAEIRQQ 229
+ +R+++E+ +ER E ++R ++ E RQQ
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKR--EEPEEERRQQ 632
Score = 38.1 bits (87), Expect = 0.034
Identities = 27/103 (26%), Positives = 56/103 (54%), Gaps = 6/103 (5%)
Query: 133 KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR----RLEEQRLK 188
+K E +L +ER E++ + + + + E+E+ + E+QL+ ++R R EE++L+
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRK-FREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 189 AEQRRAAL-EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E++ L +ER RQ + + + +R ++ W E Q+R
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Score = 37.7 bits (86), Expect = 0.045
Identities = 35/141 (24%), Positives = 60/141 (42%), Gaps = 12/141 (8%)
Query: 82 PQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKL 141
P+EE + R + + + + + D QE +++ E+ +
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 142 AK------ERREERAKYLAAKKAV--WLEKEEKAKALREKQLQ----ERRRRLEEQRLKA 189
K E R+ R L AK A+ L KE++ E++LQ E+RRR E++R
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931
Query: 190 EQRRAALEERQRQKLEKNKER 210
E+ + EE Q + E+ K R
Sbjct: 932 EEEQLQQEEEQLLREEREKRR 952
Score = 37.7 bits (86), Expect = 0.045
Identities = 25/96 (26%), Positives = 52/96 (54%), Gaps = 3/96 (3%)
Query: 124 DSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE 183
+ P +++ ++ RH ++ REE + L + L ++E+ + RE++ Q RR+ E
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEE-QLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706
Query: 184 EQRLKAEQ--RRAALEERQRQKLEKNKERYEAAIQR 217
+ L+ EQ RR LE + R++ + +E + ++R
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Score = 37.4 bits (85), Expect = 0.059
Identities = 26/96 (27%), Positives = 50/96 (52%), Gaps = 7/96 (7%)
Query: 133 KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQ- 191
+++ ++ +L + R+ R + L ++ W E+EE+ E+QLQ + E+ EQ
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRA--EEEQLQSCKGHETEEFPDEEQL 210
Query: 192 -RRAALEERQR---QKLEKNKERYEAAIQRSVKKTW 223
RR LE R++ +K ++ +ER + Q +K W
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW 246
Score = 37.4 bits (85), Expect = 0.059
Identities = 28/105 (26%), Positives = 61/105 (58%), Gaps = 5/105 (4%)
Query: 129 KQEVKKAGERHKLAKE-RREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+Q +K+ E +L + R E++ + ++ L K E+ K L +++ ++R +R +E+R
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER- 574
Query: 188 KAEQRRAALEERQRQKLEK-NKERYEAAIQR-SVKKTWAEIRQQR 230
+Q EER++Q+L++ +ER E ++R V++ E R+++
Sbjct: 575 -RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Score = 37.0 bits (84), Expect = 0.076
Identities = 27/107 (25%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 127 PTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQR 186
P ++++++ K R E++ + + V+ E+EEK RE L++ +L+E+
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 187 LKAEQRRAALEERQRQKLEK---NKERYEAAIQRSVKKTWAEIRQQR 230
QR EE Q +KLE+ +ER E Q+ + ++R+++
Sbjct: 265 -PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310
Score = 37.0 bits (84), Expect = 0.076
Identities = 25/97 (25%), Positives = 55/97 (56%), Gaps = 4/97 (4%)
Query: 138 RHKLAKERREERAK-YLAAKKAVWLEKEEKAKALREKQLQERRRRL-EEQRLKAEQRRAA 195
R + K RR+ER + Y KK E++ + +++ QER ++ EE+ L+ E+ +
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 196 LEERQRQKLEKNKERY--EAAIQRSVKKTWAEIRQQR 230
EER++++ ++ + +Y + +Q+ ++ E R++R
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Score = 37.0 bits (84), Expect = 0.076
Identities = 30/136 (22%), Positives = 63/136 (46%), Gaps = 9/136 (6%)
Query: 104 RDARPPRRSSQ------PSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKK 157
RD RR Q P + + K+ +K+ E +L +E REE+ + +
Sbjct: 1277 RDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR 1336
Query: 158 AVWLEKE---EKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAA 214
E++ E+ + +Q ++R+ R EE R + + R+ EE++ ++ E+ ++ +
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE 1396
Query: 215 IQRSVKKTWAEIRQQR 230
Q ++ ++RQ R
Sbjct: 1397 QQLRCQEREQQLRQDR 1412
Score = 36.6 bits (83), Expect = 0.100
Identities = 27/98 (27%), Positives = 51/98 (52%), Gaps = 13/98 (13%)
Query: 149 RAKYLAAKKAVWLEKEEKAKAL-REKQLQERR------------RRLEEQRLKAEQRRAA 195
+A Y A +A L++E++A+ +E LQ+RR R+LEE+ + +++
Sbjct: 83 QACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ 142
Query: 196 LEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSW 233
+ER+ + E+ E+ E QR ++ E+ +QR W
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW 180
Score = 36.6 bits (83), Expect = 0.100
Identities = 29/108 (26%), Positives = 57/108 (52%), Gaps = 9/108 (8%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERR-RRLEEQRL 187
+Q+ ++ +R +E +E R + +K +EE+ + RE Q +E + R+LE Q L
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 188 KAEQRRAALEERQRQKLE-----KNKERYEAAIQRSVKKTWAEIRQQR 230
+ E++ EE+Q+Q+L + K+ E Q+ ++ E R+Q+
Sbjct: 287 RRERQE---EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Score = 36.6 bits (83), Expect = 0.100
Identities = 31/114 (27%), Positives = 58/114 (50%), Gaps = 15/114 (13%)
Query: 131 EVKKAGERHKL----AKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ- 185
E ++ RH L A + + + + L ++ L++EE+ K R +Q QER+ R EEQ
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK--RRRQEQERQYREEEQL 936
Query: 186 --------RLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
R + E+RR ERQ +K +K +++ E + +K + R++++
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Score = 36.6 bits (83), Expect = 0.100
Identities = 27/101 (26%), Positives = 56/101 (55%), Gaps = 6/101 (5%)
Query: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR-RLEEQRLKA 189
E ++ R +L ++ R+E ++ + E E++ + RE+Q +E + EE++L
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Query: 190 EQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E+R E+R+RQ+LE+ + R E +Q+ ++ E ++R
Sbjct: 1126 EER----EKRRRQELER-QYREEEEVQQEEEQLLREEPEKR 1161
Score = 36.2 bits (82), Expect = 0.13
Identities = 25/93 (26%), Positives = 51/93 (54%), Gaps = 8/93 (8%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR---RLEEQ 185
++E ++ +L +E+ E R + L ++ E+E + + LR +Q +ERR R E+Q
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQ----EEERREQQLRREQEEERREQQLRREQQ 382
Query: 186 RLKAEQRRAALEERQRQKLEKNKE-RYEAAIQR 217
+ +Q R + R+ Q+L + ++ R E ++R
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Score = 36.2 bits (82), Expect = 0.13
Identities = 29/104 (27%), Positives = 57/104 (54%), Gaps = 11/104 (10%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
T+QE + ER++ E + R + ++ L ++E+ + RE++ + R+ EEQ+L
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPE----REEQQLRRQERDRKFREEE--QLRQEREEQQL 1788
Query: 188 KAEQ--RRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
++++ R+ EE+ RQ+ E+ + R + QR K W E + Q
Sbjct: 1789 RSQESDRKFREEEQLRQEREEQQLRPQ---QRDGKYRWEEEQLQ 1829
Score = 36.2 bits (82), Expect = 0.13
Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 12/111 (10%)
Query: 127 PTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQR 186
P +++ K E +L E +E+R + E++ + +A + QE+ RR EEQ
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQ---------ERDRQYRAEEQFATQEKSRR-EEQE 1863
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGAL 237
L E+ + +ER+R+ E++ R + QR + EI+ Q G L
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQR--HRQVGEIKSQEGKGHGRL 1912
Score = 35.8 bits (81), Expect = 0.17
Identities = 33/118 (27%), Positives = 58/118 (49%), Gaps = 17/118 (14%)
Query: 129 KQEVKKAGERHK----LAKERREERAKYLAAKKAVWLEKEEKAKAL-----REKQLQERR 179
KQ++K+ E + L E E R + ++ + E+EE+ + E++LQ+R
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL 532
Query: 180 RRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQR-------SVKKTWAEIRQQR 230
R ++ R + E+RR L +R+ +K +ER E ++R + K E RQQR
Sbjct: 533 RSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Score = 35.4 bits (80), Expect = 0.22
Identities = 33/135 (24%), Positives = 63/135 (46%), Gaps = 11/135 (8%)
Query: 104 RDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEK 163
R+ + RR Q ++E ++ E+ +L +E+ EER + ++ +
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQ-QLRREQEEERREQQLRREQEEERR 373
Query: 164 EEKAKALREKQLQERRRRLEEQRLKAEQ--------RRAALEERQRQKLEKNKERYEAAI 215
E++ + RE+QL+ ++ EQ+L+ EQ RR R++Q + + R E
Sbjct: 374 EQQLR--REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 216 QRSVKKTWAEIRQQR 230
+R +K E R+QR
Sbjct: 432 ERHEQKHEQERREQR 446
Score = 35.4 bits (80), Expect = 0.22
Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 8/106 (7%)
Query: 106 ARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEE 165
ARPP R + + A + +Q E + + +R ER K L +LE+EE
Sbjct: 786 ARPPLREQRERQ--LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ-----FLEEEE 838
Query: 166 KAKAL-REKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKER 210
+ + R +QLQE L+E + + + +++ R +LE+ ++R
Sbjct: 839 QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Score = 35.0 bits (79), Expect = 0.29
Identities = 20/102 (19%), Positives = 55/102 (53%), Gaps = 3/102 (2%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E K+ +R + ++ E+ + ++ E+EE+ + L ++L+ R+ E+Q+ +
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR 299
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ + +++ ++ E+ +ER E Q+ ++ E R+Q+
Sbjct: 300 LRREQQLRRKQEEERREQQEERRE---QQERREQQEERREQQ 338
Score = 35.0 bits (79), Expect = 0.29
Identities = 19/93 (20%), Positives = 54/93 (58%), Gaps = 6/93 (6%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
E +L ++ RE++ ++ +K E+ + L+E + Q+ RR+ +++ + E+++
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKF-----REEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 197 EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+ER+R+ L++ ++ ++R ++ ++RQ+
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREE-EQLRQE 1734
Score = 34.7 bits (78), Expect = 0.38
Identities = 22/90 (24%), Positives = 46/90 (51%), Gaps = 6/90 (6%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVW---LEKEEKA---KALREKQLQERRRRL 182
K+E ++ +LA+E +E+ + + ++ W LE E A K + QE +RR
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYE 212
+EQ K +R + L+ ++ ++ + ++ E
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 34.7 bits (78), Expect = 0.38
Identities = 30/110 (27%), Positives = 60/110 (54%), Gaps = 9/110 (8%)
Query: 129 KQEVKKAGE---RHKLAKERREERAKYLAAKKAVWLEKEE---KAKALREKQLQERRRRL 182
K E+++ E R + K R +ER + ++ + E+E+ + + R +Q ER+ R
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 183 EEQRLKAEQR--RAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
EE+ + E++ R E+R+RQ+ E+ + R E +Q+ ++ E R++R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERER-QCREEEELQQEEEQLLREEREKR 1131
Score = 34.7 bits (78), Expect = 0.38
Identities = 27/95 (28%), Positives = 48/95 (50%), Gaps = 7/95 (7%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALE 197
R +L ++ REE ++ +E K L E+QL+ R EEQ+L+ ++R
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER---EEQQLRRQERDRKF- 1773
Query: 198 ERQRQKLEKNKERYEAAIQRSVKKTWAE--IRQQR 230
R+ ++L + +E + Q S +K E +RQ+R
Sbjct: 1774 -REEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Score = 34.3 bits (77), Expect = 0.50
Identities = 24/101 (23%), Positives = 49/101 (48%), Gaps = 12/101 (11%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+QE ++ + + +ERRE+R L++EE+ + L ++ +E EQ L
Sbjct: 638 EQEERRQQQLRREQQERREQR-----------LKREEEEERLEQRLKREHEEERREQEL- 685
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
AE+ + ER + ++ K + + E+ K ++ R+Q
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQ 726
Score = 34.3 bits (77), Expect = 0.50
Identities = 26/100 (26%), Positives = 54/100 (54%), Gaps = 4/100 (4%)
Query: 110 RRSSQPSPTAVPASDSPPTKQEVKKAGERHK-LAKERREERAKYLAAKKAVWLEKEEKAK 168
R+S Q + +QE ++ +R + +E + ER + AK+ +EEK +
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK-Q 1319
Query: 169 ALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208
LRE++ ++RRR+ +++ + E++ L+ER+ Q L + +
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQ--LLQEREEQPLRRQE 1357
Score = 34.3 bits (77), Expect = 0.50
Identities = 24/103 (23%), Positives = 54/103 (52%), Gaps = 10/103 (9%)
Query: 129 KQEVKKAGERHKLAKE----RREERAKYLAAKKAVWLEKEEKAKALRE-----KQLQERR 179
+Q++ + + K +E RR+ER + + +EE+ + RE +Q ++R+
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 180 RRLEEQRL-KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKK 221
RLEEQ++ + EQ R +E+ Q+ + ++ +++ R ++
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Score = 33.9 bits (76), Expect = 0.65
Identities = 22/100 (22%), Positives = 55/100 (55%), Gaps = 5/100 (5%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE-----QRLKAEQ 191
ER + ++RR+++ ++ ++ AK ++QL++ ++ L+E QR + E+
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 192 RRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
RR +ERQ ++ E+ ++ E ++ +K + R++++
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Score = 33.9 bits (76), Expect = 0.65
Identities = 29/113 (25%), Positives = 60/113 (53%), Gaps = 21/113 (18%)
Query: 129 KQEVKKAGERHKLAKE----RREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
+Q++++ K +E RR+ER + +L++E++ LR ++L+ + R E+
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERER-------KFLQEEQQ---LRRQELERKFREEEQ 1730
Query: 185 QRLKAEQRRAALEERQRQKLEKNK---ERYEAAIQRSVK----KTWAEIRQQR 230
R + EQ + +ER R+ LE+ + ER E ++R + + ++RQ+R
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783
Score = 33.5 bits (75), Expect = 0.85
Identities = 33/103 (32%), Positives = 57/103 (55%), Gaps = 20/103 (19%)
Query: 140 KLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQ--RRAAL- 196
+L +E++ R + L ++ + E+EE+ R +Q E+ RR EQRLK EQ RR L
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEE----RHEQKHEQERR--EQRLKREQEERRDWLK 459
Query: 197 ---------EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ER++Q+L++++E E +R +K E R+Q+
Sbjct: 460 REEETERHEQERRKQQLKRDQE--EERRERWLKLEEEERREQQ 500
Score = 33.5 bits (75), Expect = 0.85
Identities = 36/158 (22%), Positives = 71/158 (44%), Gaps = 11/158 (6%)
Query: 83 QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHK-- 140
Q E S + R P + + R R + + +Q ++ ER K
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 141 --LAKE---RREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQ---R 192
L +E +R ERA+ L ++ E +E+ ++ +++ Q+ R +LEE+R +
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 193 RAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ AL+E+ R++ + +E E +QR ++ Q+R
Sbjct: 892 KPALQEQLRKEQQLLQEE-EEELQREEREKRRRQEQER 928
Score = 33.5 bits (75), Expect = 0.85
Identities = 25/112 (22%), Positives = 57/112 (50%), Gaps = 7/112 (6%)
Query: 124 DSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL--QERRRR 181
+ P +QE + +L +E+ K+L ++ + ++ E+ E+QL QER ++
Sbjct: 1350 EQPLRRQERDRKFREEEL--RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 182 LEEQR---LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
L + R + E+++ + +ER R+ E+ ++ +R + ++RQ+R
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Score = 32.7 bits (73), Expect = 1.4
Identities = 31/117 (26%), Positives = 59/117 (50%), Gaps = 24/117 (20%)
Query: 125 SPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRR---- 180
S P KQE ++ + + + RRE L+ +E+ +A R++Q +E+RR
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESE-----------LQWQEEERAHRQQQEEEQRRDFTW 769
Query: 181 --RLEEQRLKAEQRRAA----LEERQRQ-KLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ EE+ + QR +A E+R+RQ + E+ ++R + + +K + R+QR
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK--EQRRRQR 824
Score = 32.3 bits (72), Expect = 1.9
Identities = 24/112 (21%), Positives = 50/112 (44%), Gaps = 8/112 (7%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKE----EKAKALREKQLQERRRRLEEQRLKAEQRR 193
+H L +++ +R + ++ W +++ E+ + RE+Q + +RR + Q K R
Sbjct: 1268 QHLLGEQQERDREQ----ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE 1323
Query: 194 AALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHK 245
E+R+RQ+ ++ E +Q ++ + R L H G K
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Score = 32.3 bits (72), Expect = 1.9
Identities = 26/111 (23%), Positives = 53/111 (47%), Gaps = 10/111 (9%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKK----AVWLEKEEKAKALREKQLQERRRRLE- 183
++E K E +L + RE++ + +K L ++E+ + RE++ Q RR+ E
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446
Query: 184 -----EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
EQ+L+ E+ R EE Q + + ++ + R + ++R+Q
Sbjct: 1447 KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Score = 32.0 bits (71), Expect = 2.5
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
++QE + + R+E K+L ++ + E+ K + E+ LQER EEQ+L
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE-EEQLLQER----EEQQL 1478
Query: 188 KAEQR-RAALEERQRQKLEKNKERYEAAIQRS 218
++R R LEE Q+ + ++ ++ RS
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Score = 32.0 bits (71), Expect = 2.5
Identities = 25/101 (24%), Positives = 52/101 (51%), Gaps = 4/101 (3%)
Query: 133 KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQ---ERRRRLEEQRL-K 188
+K E +L +ER E++ + E+ + + RE+QL+ +R+ R EEQ L +
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
E+++ +ER R+ E+ ++ +R + ++R+Q
Sbjct: 1679 GEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Score = 31.6 bits (70), Expect = 3.2
Identities = 23/83 (27%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Query: 137 ERHKLAKERR-EERAKYLAAKKAVWLEKEEKAKA-LREKQLQERRRRLEEQRLKAEQRRA 194
ER + + RR ++R ++ ++ LE+EE+ +A R+++ QE ++ L E+R + ++RR
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQ--LEREEQKEAKRRDRKSQEEKQLLREER-EEKRRRQ 1332
Query: 195 ALEERQRQKLEKNKERYEAAIQR 217
+ + R++ + +ER E ++R
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRR 1355
Score = 31.6 bits (70), Expect = 3.2
Identities = 23/108 (21%), Positives = 58/108 (53%), Gaps = 7/108 (6%)
Query: 127 PTKQEVKKAGERHKLAKERR--EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
P ++ +++ + H+ ++R+ +E + ++ ++ K E+QL++ R EE
Sbjct: 1513 PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER---EE 1569
Query: 185 QRLKAEQR--RAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
Q+L ++R + LEE++ ++ E+ ++ E Q ++ ++RQ+R
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Score = 31.6 bits (70), Expect = 3.2
Identities = 30/111 (27%), Positives = 55/111 (49%), Gaps = 11/111 (9%)
Query: 129 KQEV-KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL--QERRRRLEEQ 185
+QE+ +K E +L +E +E+ + + + LE+E+ E+QL QER R+ E+
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKI-LEEEQLRPEREEQQLRRQERDRKFREE 1776
Query: 186 RLKAEQRRAALEERQRQKLE---KNKERYEAAIQRSVKKTWAEIRQQRWSW 233
EQ R EE+Q + E K +E + +R ++ + R ++ W
Sbjct: 1777 ----EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823
Score = 31.2 bits (69), Expect = 4.2
Identities = 20/107 (18%), Positives = 49/107 (45%), Gaps = 10/107 (9%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE----- 183
+Q++++ + + + +REE + L + E+E + + L E++ ++ R R++
Sbjct: 644 QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 184 -----EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAE 225
E A Q + R+++ + +E+ E +R + W E
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Score = 31.2 bits (69), Expect = 4.2
Identities = 25/95 (26%), Positives = 48/95 (50%), Gaps = 4/95 (4%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL-QERRRRL-EEQRLKAEQRRA 194
E +L+++ R+ K+ ++ V ++ E+ E+QL QER R+ EE++L E+
Sbjct: 1419 EEQQLSRQERDR--KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Query: 195 ALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
L ++R + +E+ +R K E+R Q
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511
Score = 31.2 bits (69), Expect = 4.2
Identities = 27/116 (23%), Positives = 57/116 (49%), Gaps = 16/116 (13%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQ----ERRRRLEE 184
++E + ER + R+E K+L ++ L ++E+ + RE++L+ ER+ EE
Sbjct: 1464 REEEQLLQEREEQQLHRQERDRKFLEEEQQ--LRRQERDRKFREQELRSQEPERKFLEEE 1521
Query: 185 QRLKAEQRRAAL----------EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
Q+L +QR+ E Q+++ +++++ E R ++ RQ+R
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Score = 30.8 bits (68), Expect = 5.5
Identities = 28/109 (25%), Positives = 54/109 (49%), Gaps = 13/109 (11%)
Query: 138 RHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALE 197
+ L ++RR+E + + LE+E + +++Q QER E++ + ++R LE
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQER---LE 162
Query: 198 ERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKT 246
+R RQ+ ++ R ++ W E R++R + L S GH+T
Sbjct: 163 QRDRQRRDEELWRQ--------RQEWQE-REERRAEEEQL-QSCKGHET 201
Score = 30.0 bits (66), Expect = 9.3
Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 11/95 (11%)
Query: 145 RREERAKYLAAKKAVWLEKEEKAKALREKQ---LQERRRRL--EEQRL----KAEQRRAA 195
RR+ER + ++ +E + K L E+Q Q+R+R+ EEQ+L + +QRR
Sbjct: 1495 RRQERDRKFREQEL--RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552
Query: 196 LEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ + R++ + +ER E + R + + +Q+
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587
Score = 30.0 bits (66), Expect = 9.3
Identities = 23/89 (25%), Positives = 46/89 (51%), Gaps = 9/89 (10%)
Query: 133 KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQR 192
+K E +L +ER E++ + LE E+K + +Q QER+ +EQ+L+ ++
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLE-EQKVR----RQEQERKFMEDEQQLRRQEG 1609
Query: 193 RAALEERQRQKLEKN----KERYEAAIQR 217
+ L + + +K ++ +ER E + R
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHR 1638
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 86.3 bits (212), Expect = 1e-16
Identities = 172/727 (23%), Positives = 293/727 (40%), Gaps = 84/727 (11%)
Query: 107 RPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERRE--ERAKYLAAKKAVWLEKE 164
R P +P+ PA + P ++ A + +L + R+E E+A+ L +A E
Sbjct: 234 REPLCLRPEAPSRAPA-EGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLE 292
Query: 165 EKAKALREKQL----QERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVK 220
+ + LR++ Q +R L + +A + RA R +++L + +ER +AA
Sbjct: 293 AEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAA------ 346
Query: 221 KTWAEIRQQRWSWAGALHHSSP--GHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLW 278
+ + ++ +G L S + +R + ++ + + ++ RL ++ A L
Sbjct: 347 EAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAEL- 405
Query: 279 NSPSRNRSLQLSAWESSI---VDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPT 335
R++ QL+ + + R + P + A P + +D+ R + GR T
Sbjct: 406 -DSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAP-SLQDEVREAEAGRLRT 463
Query: 336 WGRAGASLARG------PQPDRTHPSAAVP----VCPRSASASPLTPCSVTRSVHRCAPA 385
R L RG QP HP P V P A P TP + S
Sbjct: 464 LERENREL-RGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEA-PQTPVAFDHS------- 514
Query: 386 GERGERRKPNAGGSPAPVRRRPEA--SPVQKKEKKDKERENEKEKSALARERSLKKRQSL 443
+G +K GG P + P A S ++ + + +++ +++ + + Q+
Sbjct: 515 -PQGLVQKARDGG-PQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQAS 572
Query: 444 PASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTA- 502
SP+ S E SP+ R SS + PAS P GPG T P G T
Sbjct: 573 DWSPQESGSPVETQE-SPEKAGRRSSLQS----PASVAPPQGPG-TKIQAPQLLGGETEG 626
Query: 503 --SPKGRV------RRKEEAKESPSAAGPEDKSQSKRRASNE----KESAAPASPAPSPA 550
+P+G + R+E + P + P ++ N+ A A
Sbjct: 627 REAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRL 686
Query: 551 PSPTPAPP-QKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRL-LAEKRR 608
P QK Q +E + V P P + +A +EA R +A+ RR
Sbjct: 687 EGTVRDPAWQKPQQKSEGALEVQVWEGP-------IPGESLASGVAEQEALREEVAQLRR 739
Query: 609 QAREQR-EREEQERRLQAERDKRMR---EEQLAREAEARAEREAEARRREEQEAREKAQA 664
+A E E Q R+L+A+ + R E AR AEA A REAEA+ E+ RE +A
Sbjct: 740 KAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEA 799
Query: 665 EQEEQERLQKQKEE-AEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
+E E +++E EA + ER++ ERE + + E E R ++ E R E
Sbjct: 800 AGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEE 859
Query: 724 VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE-EPIPQEPQWSLPSKELPA 782
++++++ +A + V + G + E +Q+E E E Q L KE
Sbjct: 860 AERERREKEALQAELEKA------VVRGKELGARLEHLQRELEQAALERQEFLREKESQH 913
Query: 783 SLVNGLQ 789
GL+
Sbjct: 914 QRYQGLE 920
Score = 50.8 bits (120), Expect = 5e-06
Identities = 135/634 (21%), Positives = 229/634 (36%), Gaps = 64/634 (10%)
Query: 133 KKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQR 192
++AG +L +E R R + AA+ +EE+ + L+ + LEEQ A +R
Sbjct: 324 ERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLS---GVLEASKALLEEQLEAARER 380
Query: 193 RAALEERQRQKLEKNKERYEAAIQR-SVKKTWAEIRQQRWSWAGALHHS------SPGHK 245
A L E QR+ L EA + S++ ++ ++ L S SPG
Sbjct: 381 CARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEA 440
Query: 246 T-SGSRCSVSAVNLPKHVDSII-----NKRLSKSSATLWNSPSRNRSLQLSAWESSIVDR 299
+G+ S+ + N+ L L P L + E ++
Sbjct: 441 PLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPV 500
Query: 300 L----MTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTH-- 353
L TP ++F + V R+G Q P + A A + P D
Sbjct: 501 LEEAPQTP-VAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAE 559
Query: 354 -PSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPV 412
P A + P+++ SP S + AG R + P + P + +A +
Sbjct: 560 SPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQL 619
Query: 413 QKKEKKDKE--------------RENEKEKSALARERSLKKRQSLPASPRARLSASTASE 458
E + +E +E + K + S++ + + L+ A
Sbjct: 620 LGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEA 679
Query: 459 LSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTAS--PKGRVRRKEEA-- 514
+ + +W +P S G + P P + AS + R+E A
Sbjct: 680 REHDQRLEGTVRDPAWQKPQQK--SEGALEVQVWEGPIPGESLASGVAEQEALREEVAQL 737
Query: 515 KESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVL 574
+ A G E ++Q+++ + E+A + + A + E A+ A +
Sbjct: 738 RRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAE---AQAWEQARLR 794
Query: 575 TSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREE 634
+ A + + + +RE LA R+ R Q ERE R Q+E + +
Sbjct: 795 EAVEAAGQELE-----SASQEREALVEALAAAGRE-RRQWEREGSRLRAQSEAAEERMQV 848
Query: 635 QLAREAEARAEREAEARRREEQEAR-EKAQAEQEE----QERLQKQKEEAEARSREEAER 689
+ + E E E R +E +A EKA +E E LQ++ E+A ER
Sbjct: 849 LESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQA------ALER 902
Query: 690 QRLEREKHFQQQEQERQERRKRLEEIMKRTRKSE 723
Q REK Q Q + E+R E T K E
Sbjct: 903 QEFLREKESQHQRYQGLEQRLEAELQAAATSKEE 936
Score = 44.3 bits (103), Expect = 5e-04
Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 47/168 (27%)
Query: 602 LLAEKRRQARE---QREREEQERRLQAERDK-RMREEQLAREAE-------------ARA 644
LLAE+ R ++ QR EE+ RRLQ+E D+ +M +L+RE AR
Sbjct: 1137 LLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARL 1196
Query: 645 EREAEARRREEQEAREKAQ---------------------AEQEEQERLQKQKEEAEARS 683
E E + Q+ RE Q A++EE +L + + +
Sbjct: 1197 ELERAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSREN 1256
Query: 684 REEAERQRLEREKHFQQQEQE--------RQERRKRLEEIMKRTRKSE 723
RE ER LE H ++++E R+E++K +E+IM + R E
Sbjct: 1257 RELLERS-LESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYRVLE 1303
Score = 43.5 bits (101), Expect = 8e-04
Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 36/221 (16%)
Query: 573 VLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRL---QAE--- 626
+L P P PS+ A A +L K + R ++E EE+ L QAE
Sbjct: 231 LLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQG 290
Query: 627 ---RDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARS 683
+R+R+E A +A + AE R E + RE+A QE L++ +E +A
Sbjct: 291 LEAEIRRLRQEAQALSGQA---KRAELYREEAEALRERAGRLPRLQEELRRCRERLQA-- 345
Query: 684 REEAERQRLEREK-----------HFQQQEQERQERRKRLEEIMKRT--RKSEVSETKQK 730
EA + +LE E+ ++Q + +ER RL E + ++ + E +
Sbjct: 346 -AEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAE 404
Query: 731 QDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEP 771
DS + + E V+ L+ E + EP P P
Sbjct: 405 LDSLRHQVDQLAEENVE--------LELELQRSLEPPPGSP 437
Score = 38.5 bits (88), Expect = 0.026
Identities = 39/159 (24%), Positives = 66/159 (41%), Gaps = 9/159 (5%)
Query: 602 LLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREK 661
L+AEK + + E Q LQ + + + Q A+E +R + E + QE K
Sbjct: 990 LVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRK 1049
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRK 721
+ +EE ++ +EE ++Q L R+ Q Q RQE LE ++ R R
Sbjct: 1050 LEVLEEEVRAARQSQEET------RGQQQALLRDHKALAQLQRRQE--AELEGLLVRHRD 1101
Query: 722 SEVSETKQKQDSKEANANGSSPEPVKA-VEARSPGLQKE 759
+ + + +E + +A VEA+ L E
Sbjct: 1102 LKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAE 1140
Score = 37.0 bits (84), Expect = 0.076
Identities = 41/146 (28%), Positives = 65/146 (44%), Gaps = 24/146 (16%)
Query: 597 EEATRLLAEKRRQAREQRER-EEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
E A R L + Q + QR E QE L AER++ M++ +R E R
Sbjct: 1110 ELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQD--------GHRQRGLEEELRRL 1161
Query: 656 QEAREKAQAEQEE--QERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713
Q ++AQ E +ER + Q E E R R R LER + + Q Q+ +E ++L+
Sbjct: 1162 QSEHDRAQMLLAELSRERGELQGERGELRGR--LARLELERAQ-LEMQSQQLRESNQQLD 1218
Query: 714 ----------EIMKRTRKSEVSETKQ 729
E++ + R ++ E +Q
Sbjct: 1219 LSACRLTTQCELLTQLRSAQEEENRQ 1244
Score = 35.0 bits (79), Expect = 0.29
Identities = 28/90 (31%), Positives = 44/90 (48%), Gaps = 19/90 (21%)
Query: 130 QEVKKAGERH--KLAKERREERAKYLAAKKAVWLEKE-----------------EKAKAL 170
Q ++ G +H + +ERRE+ A +KAV KE E+ + L
Sbjct: 847 QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFL 906
Query: 171 REKQLQERRRRLEEQRLKAEQRRAALEERQ 200
REK+ Q +R + EQRL+AE + AA + +
Sbjct: 907 REKESQHQRYQGLEQRLEAELQAAATSKEE 936
Score = 33.1 bits (74), Expect = 1.1
Identities = 33/100 (33%), Positives = 47/100 (47%), Gaps = 9/100 (9%)
Query: 619 QERRLQAERDKRMREEQ----LAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQK 674
+ER L A+R + E+ L EA +RA E + Q A KAQ + QE
Sbjct: 218 RERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQEL--- 274
Query: 675 QKEEAEARSREEAERQRLERE-KHFQQQEQERQERRKRLE 713
+E+AE +AE Q LE E + +Q+ Q + KR E
Sbjct: 275 -EEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAE 313
Score = 30.4 bits (67), Expect = 7.2
Identities = 38/168 (22%), Positives = 65/168 (38%), Gaps = 17/168 (10%)
Query: 52 PPAMKNAT-SSKQLPLEPES-PSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPP 109
PPA+ + +S + P P+S P P A + S + +P +
Sbjct: 534 PPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQESPEKAG 593
Query: 110 RRSSQPSPTAVPASDSPPTKQEVKK------------AGERHKLAKERREERAKYL---A 154
RRSS SP +V P TK + + GE A R+E ++ +
Sbjct: 594 RRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPS 653
Query: 155 AKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQ 202
+V LE++E + + R +QRL+ R A ++ Q++
Sbjct: 654 EPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQK 701
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 85.5 bits (210), Expect = 2e-16
Identities = 82/331 (24%), Positives = 141/331 (42%), Gaps = 56/331 (16%)
Query: 503 SPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAP----------- 551
SPK E + S ++ E+K ++ ++ + S PA P+ + P
Sbjct: 344 SPK---ENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQER 400
Query: 552 --SPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTD------REEATRLL 603
S PP K P D + P P P SK D R + + +
Sbjct: 401 GTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFP----SKQQVADEDEIWKQRRRQQSEIS 456
Query: 604 A--EKRRQAREQRER--EEQERRLQAERDKRMRE------------EQLAREAEARAERE 647
A E+ R+ RE+ ER EEQ + AE+ KR+ E E RE E ERE
Sbjct: 457 AAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKERERE 516
Query: 648 AEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQE 707
E + +EQE ++ + ++E Q+ +K+ E+ + + RE + ++ E+EK ++Q+++ +E
Sbjct: 517 KELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKE 576
Query: 708 RRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPI 767
+K E+ + + E + ++K + +E N EP+ + KE EEP+
Sbjct: 577 LQKMKEQEKECELEKEREKLEEKIEPREPNL-----EPMVEKQESENSCNKE----EEPV 627
Query: 768 PQEPQWSLPSKELPASL-----VNGLQPLPA 793
+ KE + +G QP PA
Sbjct: 628 FTRQDSNRSEKEATPVVHETEPESGSQPRPA 658
Score = 76.3 bits (186), Expect = 1e-13
Identities = 104/482 (21%), Positives = 185/482 (38%), Gaps = 78/482 (16%)
Query: 345 RGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRK----------- 393
RGP P A+ P P SAS L ++ A G G + +
Sbjct: 281 RGPPPSW----ASEPERPSILSASELKELDKFDNLDAEADEGWAGAQMEVDYTEQLNFSD 336
Query: 394 PNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSA 453
+ GS +P E + K + EN+KE ++ +S + +PA P
Sbjct: 337 DDEQGSNSPKENNSE----DQGSKASENNENKKETDEVSNTKSSSQ---IPAQP------ 383
Query: 454 STASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEE 513
S A K + TS H P P P PP R G K++
Sbjct: 384 SVAKVPYGKGPSFNQERGTSSHLP------PPPKLLAQQHPPPDRQAVPGRPGPFPSKQQ 437
Query: 514 AKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV 573
+ ED+ +RR + SAA ++E+ E AA
Sbjct: 438 VAD-------EDEIWKQRRRQQSEISAAVERARKRR---------EEEERRMEEQRKAAC 481
Query: 574 LTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQRERE---EQERRLQAERDK- 629
A + G +++ + + E+ R+ +RE+E EQE+ + ER+K
Sbjct: 482 -------AEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKD 534
Query: 630 RMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER 689
R R+++ +E E E++ E + +QE ++ + ++E+++ LQK KE+ E E ER
Sbjct: 535 RERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQ-EKECELEKER 593
Query: 690 QRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEAN--------ANGS 741
++LE + ++ E ++ E + + + + KEA +GS
Sbjct: 594 EKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGS 653
Query: 742 SPEPV-------KAVEARSPGLQKEAVQ-KEEPIPQEPQWSLPSKELPASLVNGLQPLPA 793
P P + ++ P Q++ Q K++ Q+ Q + + +P+ + P P
Sbjct: 654 QPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPP 713
Query: 794 HQ 795
H+
Sbjct: 714 HR 715
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/212 (24%), Positives = 89/212 (41%), Gaps = 20/212 (9%)
Query: 33 PSPP-------PPPMSALVPDTPPDTPPAMKNATSS---KQLPLEPESPSGQVGPRPAPP 82
P PP PPP VP P P + A KQ + S V
Sbjct: 407 PPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRR 466
Query: 83 QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTK---------QEVK 133
+EE E + + + D + QPSP + + + QE +
Sbjct: 467 EEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQE 526
Query: 134 KAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRR 193
+ ER K +ER++E+ K L ++ E E++ K +EK+L+ ++ + +E + EQ +
Sbjct: 527 REKEREK-DRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEK 585
Query: 194 AALEERQRQKLEKNKERYEAAIQRSVKKTWAE 225
E++R+KLE+ E E ++ V+K +E
Sbjct: 586 ECELEKEREKLEEKIEPREPNLEPMVEKQESE 617
Score = 52.8 bits (125), Expect = 1e-06
Identities = 46/169 (27%), Positives = 81/169 (47%), Gaps = 26/169 (15%)
Query: 55 MKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQ 114
+ N SS Q+P +P G P+ QE SS P PP + + PP R
Sbjct: 370 VSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHL----PPPPKLLAQQHPPPDRQ-- 423
Query: 115 PSPTAVPASDSP-PTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREK 173
AVP P P+KQ+V + ++ K+RR ++++ AA + +EE+ + + E+
Sbjct: 424 ----AVPGRPGPFPSKQQV---ADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQ 476
Query: 174 Q---LQERRRRLEEQ------RLKAEQRRAALEERQRQK---LEKNKER 210
+ E+ +RL+E+ + E+ R E++R++ LEK +E+
Sbjct: 477 RKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQ 525
Score = 50.8 bits (120), Expect = 5e-06
Identities = 83/386 (21%), Positives = 143/386 (37%), Gaps = 39/386 (10%)
Query: 402 PVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSL--PASPRARLSASTASEL 459
P R+R + +K D++R R + ++ + P + +SE
Sbjct: 919 PSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEG 978
Query: 460 SPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKE----EAK 515
K S T W P PS + +P G P R ++E + K
Sbjct: 979 PKPEKVYKSKSETRW----GPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEK 1034
Query: 516 ESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAE--TPTDAAV 573
E A +K K + +K+ P P PAP + P QP AE T+ A
Sbjct: 1035 EGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETAT 1094
Query: 574 LTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQE----RRLQAERDK 629
L P+ P +P++ T E A + + ++ A +E ++ E + L ER +
Sbjct: 1095 LAQKPS-QDTEKPLEPVS-TVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPR 1152
Query: 630 RMREEQLAREAEARAERE-AEARRRE---EQEAREKAQAEQEEQERLQKQKEEAEAR--- 682
+ +E+ EAR R+ +Q R + + E + R + R
Sbjct: 1153 PDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGR 1212
Query: 683 --SREEAE-RQRLEREKHF------QQQEQERQERRKRLEEIMKRTRK--SEV---SETK 728
+R+ + R R +H Q++E E + E + KR R+ SE SE
Sbjct: 1213 GHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEIH 1272
Query: 729 QKQDSKEANANGSSPEPVKAVEARSP 754
+ K++ + G P+ + E + P
Sbjct: 1273 ESASDKDSLSKGKLPKREERPENKKP 1298
Score = 48.1 bits (113), Expect = 3e-05
Identities = 70/287 (24%), Positives = 106/287 (36%), Gaps = 43/287 (14%)
Query: 310 RSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASP 369
RS+++ PR + Q G + + LA P P T SA+VP + +
Sbjct: 1719 RSQTSKLPPRFAKKQATGIQQAQSSA---SVPPLASAPLPPST--SASVPASTSAPLPAT 1773
Query: 370 LTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKS 429
LTP V S PA P + APV ASP+ + +
Sbjct: 1774 LTP--VPASTSAPVPASTLA----PVLASTSAPV----PASPLAPVSASASVSASVPAST 1823
Query: 430 ALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHT 489
+ A S S PA S ST + ++ + A S P + ++ P+P P +
Sbjct: 1824 SAAAITSSSAPASAPAPTPILASVSTPASVTILASA--SIPILASALASTSAPTPAPAAS 1881
Query: 490 LPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSP 549
P P T + +P+A+ P + SA+ +PAP+P
Sbjct: 1882 SPAAPVITAPTIPA------------SAPTASVPLAPA-----------SASAPAPAPTP 1918
Query: 550 APSPTPAPPQKEQPPAET---PTDAAVLTSPPAPAPPVTPSKPMAGT 593
+P PAPP Q A+T + TS + PP + P A T
Sbjct: 1919 VSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQT 1965
Score = 47.8 bits (112), Expect = 4e-05
Identities = 65/235 (27%), Positives = 85/235 (36%), Gaps = 57/235 (24%)
Query: 404 RRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKS 463
RR+ E +Q KK+ + + S L + K+ + +A+ SAS P
Sbjct: 1698 RRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGIQ---QAQSSASV-----PPL 1749
Query: 464 KARPSSPSTSWHRPAS---PCPS---PGPGHTLPPKPPSPRGTT-ASPKGRVRRKEEAKE 516
+ P PSTS PAS P P+ P P T P P S AS V A
Sbjct: 1750 ASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVPASPLAPV 1809
Query: 517 SPSAAGPEDKSQSKRRASNEKESAAPASPAPSP--------------------------- 549
S SA+ S A+ SA ++PAP+P
Sbjct: 1810 SASASVSASVPASTSAAAITSSSAPASAPAPTPILASVSTPASVTILASASIPILASALA 1869
Query: 550 ---APSPTPAPPQKEQP-------PAETPTDAAVL----TSPPAPAP-PVTPSKP 589
AP+P PA P PA PT + L S PAPAP PV+ P
Sbjct: 1870 STSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPVSAPNP 1924
Score = 44.7 bits (104), Expect = 4e-04
Identities = 149/748 (19%), Positives = 238/748 (31%), Gaps = 149/748 (19%)
Query: 21 TPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSS-KQLPLEPESPSGQVGPRP 79
TP PE P P +S PP + KQ + + G V P+
Sbjct: 641 TPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQG-VLPQT 699
Query: 80 APPQEESPSSEAKSRGPTPPAMGPRDARP---------PR---RSSQPSPTAV---PASD 124
P Q PSS P P P P PR S P + PA D
Sbjct: 700 VPSQ---PSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMD 756
Query: 125 SPPTKQEV---------------KKAGERHKLAKERREERAKYLAAKKAVW----LEKEE 165
PP + + E + + A L+ + +W E
Sbjct: 757 IPPIHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARDHAISLSEPRMLWGSDPYPHAE 816
Query: 166 KAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQ-----KLEKNKERYEAAIQRSVK 220
+A K +E E L EQ AA Q K + +E EA +Q+ +
Sbjct: 817 PQQATTPKATEEPEDVRSEAALDQEQITAAYSVEHNQLEAHPKADFIRESSEAQVQKFLS 876
Query: 221 KTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNS 280
++ ++R P H + ++ + K + + +R+S + +
Sbjct: 877 RSVEDVR--------------PHHTDANNQSACFEAPDQKTLSAPQEERIS----AVESQ 918
Query: 281 PSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAG 340
PSR RS+ + + D RS + +P+ +P P
Sbjct: 919 PSRKRSVSHGSNHTQKPDE---------QRSEPSAGIPKVTSRCIDSKEPIERPEEKPKK 969
Query: 341 ASLAR---GPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAG 397
R GP+P++ + S + T S +R +R RR +G
Sbjct: 970 EGFIRSSEGPKPEKVYKSKSE------------TRWGPRPSSNRREEVNDRPVRR---SG 1014
Query: 398 GSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTAS 457
PV R + Q+KEK+ ++ E EK + E++ KK
Sbjct: 1015 PIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKK------------------ 1056
Query: 458 ELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKES 517
P P P PP+PP+P + P E+ +
Sbjct: 1057 ----------------------DLPPPPP----PPQPPAPIQPQSVPPPIQPEAEKFPST 1090
Query: 518 PSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPP---QKEQPPAETPTDAAVL 574
+A + SQ + E S PA T A P +++QP D +
Sbjct: 1091 ETATLAQKPSQDTEKPL-EPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIE 1149
Query: 575 TSPPAPAPPVTPSKPMAGTTDREEATR--LLAEKRRQAREQREREEQERRLQAERDKR-- 630
P P V + T +EA ++ + R + E + R + R
Sbjct: 1150 RPRPDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGR 1209
Query: 631 -----MREEQLAREAEARAER--EAEARRREEQEAR-EKAQAEQEEQERLQKQKEEAEAR 682
R+ R+ + RAE R+REE E R E + E + R Q+ E
Sbjct: 1210 GGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDS 1269
Query: 683 SREEAERQRLEREKHFQQQEQERQERRK 710
E+ + K + +ER E +K
Sbjct: 1270 EIHESASDKDSLSKGKLPKREERPENKK 1297
Score = 43.9 bits (102), Expect = 6e-04
Identities = 155/829 (18%), Positives = 286/829 (34%), Gaps = 119/829 (14%)
Query: 17 VVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAM----------------KNATS 60
V + +P + + D PPPPP P P PP + + +
Sbjct: 1042 VTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQ 1101
Query: 61 SKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRD--ARPPRRSSQPSPT 118
+ PLEP S + QV P +++ ++ P + +D PR S+P
Sbjct: 1102 DTEKPLEPVS-TVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRP--- 1157
Query: 119 AVPASDSPPTKQEVKKAGERHKLAKE--RREERAKYLAAKKAVWLEKEEKAKALREKQLQ 176
AV + P + K+A ER + R R +Y + ++ + + R
Sbjct: 1158 AVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRD 1217
Query: 177 ERRRRLEEQRLKAEQ-RRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAG 235
+ R + + +AE L +R+ + +E +R R+QR S
Sbjct: 1218 YPQYR--DNKPRAEHIPSGPLRQREESETRSESSDFEVVPKR---------RRQRGSETD 1266
Query: 236 ALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESS 295
S H+++ + S+S LPK + NK+ K ++ P + + E
Sbjct: 1267 T---DSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSF--KPDNHVRIDNRLLEKP 1321
Query: 296 IVDRLMTPTLSFL-----ARSRSAVTLPRNGRDQ-GRGCDPG--RGPTW--GRAGASLAR 345
V FL R T R GRD GR P R P + + +
Sbjct: 1322 YVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSE 1381
Query: 346 GPQP-DRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVR 404
P+P D P P +A P + + PA ER R++P P
Sbjct: 1382 VPKPEDGEPPRRHEQFIPIAADKRP------PKFERKFDPARERPRRQRPT---RPPRQD 1432
Query: 405 RRPEASPVQKKEKKDKERE------------NEKEKSALARERSLKKRQSLP---ASPRA 449
+ P ++++E K E +E + S K L +S +A
Sbjct: 1433 KPPRFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQA 1492
Query: 450 RLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVR 509
TASE S ++ R + A G + LPPK + + +S + R
Sbjct: 1493 NEEWETASESSDFNERRERDEKKNADLNAQTVVKVGE-NVLPPKREIAKRSFSSQRPVDR 1551
Query: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPT 569
+ P +G ++ NE+ S P+ P +QP T
Sbjct: 1552 QNRRGNNGPPKSG-----RNFSGPRNERRSGPPSKSG--------KRGPFDDQPAGTTGV 1598
Query: 570 DAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAR--EQREREEQERRLQAER 627
D ++ A P+ G + +++T +KR + ++ +E+ + Q +
Sbjct: 1599 D--LINGSSAHHQEGVPNG--TGQKNSKDST---GKKREDPKPGPKKPKEKVDALSQFDL 1651
Query: 628 DKRMREEQLAREAEARAEREAEARRREE---QEAREKAQAEQEEQERLQKQKEEAEARSR 684
+ + E + ++ ++ + +K Q +++ER +K+++ + ++
Sbjct: 1652 NNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQKRLQDEERRKKEEQVIQVWNK 1711
Query: 685 EEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744
+ A ++ R + ++ R K + + +Q Q S S+P
Sbjct: 1712 KNA-----------------NEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLASAPL 1754
Query: 745 PVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPA 793
P + P+P +P+ L L + P+PA
Sbjct: 1755 PPSTSASVPASTSAPLPATLTPVPASTSAPVPASTLAPVLASTSAPVPA 1803
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/94 (29%), Positives = 38/94 (40%), Gaps = 10/94 (10%)
Query: 34 SPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKS 93
S P P +A P P T P + + + +PL P S S P PAP +P+
Sbjct: 1872 SAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASAS---APAPAPTPVSAPN----- 1923
Query: 94 RGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPP 127
P PPA A+ + P T +S PP
Sbjct: 1924 --PAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPP 1955
Score = 41.2 bits (95), Expect = 0.004
Identities = 40/151 (26%), Positives = 55/151 (36%), Gaps = 11/151 (7%)
Query: 5 PRAELGAGAPPAVVARTPPEPRPSPEGDPSP-PPPPMSALVPDTPPDTPPAMKNATSSKQ 63
P + A P A + + P P P+P P+P PP P P P + SSKQ
Sbjct: 1894 PASAPTASVPLAPASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQ 1953
Query: 64 LPLEPESPSGQV---------GPRPAPPQEESP-SSEAKSRGPTPPAMGPRDARPPRRSS 113
P PS Q G PQ ++E PPA+ ++ S
Sbjct: 1954 PPPSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPIS 2013
Query: 114 QPSPTAVPASDSPPTKQEVKKAGERHKLAKE 144
P P +V A + P T + E K +E
Sbjct: 2014 PPQPPSVSAWNKPLTSFGSAPSSEGAKNGQE 2044
Score = 38.9 bits (89), Expect = 0.020
Identities = 66/346 (19%), Positives = 116/346 (33%), Gaps = 48/346 (13%)
Query: 367 ASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEK 426
ASPL P S + SV PA ++ + AP AS +
Sbjct: 1803 ASPLAPVSASASVSASVPASTSAAAITSSSAPASAPAPTPILASVSTPASVTILASASIP 1862
Query: 427 EKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGP 486
++ S +SP A + + S + + P +P+++ ++P P+P P
Sbjct: 1863 ILASALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASA----SAPAPAPTP 1918
Query: 487 GHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPA 546
P PP+P T A V+ + S P + N + A
Sbjct: 1919 VSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQTPNGTDYVASGKSI 1978
Query: 547 PSPAPSPTPAP---PQKEQPPAETPTDAAVL--TSPPAPAPPVTPSKPM----------- 590
+P T K PPA + L SPP P +KP+
Sbjct: 1979 QTPQSHGTLTAELWDNKVAPPAVLNDISKKLGPISPPQPPSVSAWNKPLTSFGSAPSSEG 2038
Query: 591 ---------------------AGTTDREEATRLLAEKRR----QAREQREREEQERRLQA 625
A + E +L+EK + +EQR+++ + ++A
Sbjct: 2039 AKNGQESGLEIGTDTIQFGAPASNGNENEVVPVLSEKSADKIPEPKEQRQKQPRAGPIKA 2098
Query: 626 ERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQER 671
++ + + +E + R+ ++A+ Q E E QE+
Sbjct: 2099 QKLPDLSPVENKEHKPGPIGKERSLKNRKVKDAQ---QVEPEGQEK 2141
Score = 37.7 bits (86), Expect = 0.045
Identities = 46/210 (21%), Positives = 74/210 (35%), Gaps = 23/210 (10%)
Query: 395 NAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSAS 454
N+ S R P+ P + KEK D + + A ++ P++ L+
Sbjct: 1620 NSKDSTGKKREDPKPGPKKPKEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDD 1679
Query: 455 TASELSPKSKARPSSPSTS----------WHRPASPCPSPGPGHTLPPKPPSPRGTTASP 504
+E+ K + + W++ + LPP+ + T
Sbjct: 1680 GFTEVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQAT---- 1735
Query: 505 KGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPP 564
G + + A P A+ P S S AS ++AP +P P+ T AP P
Sbjct: 1736 -GIQQAQSSASVPPLASAPLPPSTS---ASVPASTSAPLPATLTPVPASTSAPV-----P 1786
Query: 565 AETPTDAAVLTSPPAPAPPVTPSKPMAGTT 594
A T TS P PA P+ P A +
Sbjct: 1787 ASTLAPVLASTSAPVPASPLAPVSASASVS 1816
Score = 36.6 bits (83), Expect = 0.100
Identities = 34/139 (24%), Positives = 54/139 (38%), Gaps = 5/139 (3%)
Query: 5 PRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL 64
P + L + A V+ + P + S P A P + PA +S +
Sbjct: 1802 PASPLAPVSASASVSASVPASTSAAAITSSSAPASAPAPTPILASVSTPASVTILASASI 1861
Query: 65 PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARP--PRRSSQPSPTAVPA 122
P+ + + P PA P SP++ + PT PA P + P P +S P+P P
Sbjct: 1862 PILASALASTSAPTPA-PAASSPAAPVIT-APTIPASAPTASVPLAPASASAPAPAPTPV 1919
Query: 123 S-DSPPTKQEVKKAGERHK 140
S +P + + HK
Sbjct: 1920 SAPNPAPPAPAQTQAQTHK 1938
Score = 35.4 bits (80), Expect = 0.22
Identities = 34/122 (27%), Positives = 46/122 (37%), Gaps = 10/122 (8%)
Query: 6 RAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLP 65
+A+ A PP A PP S P+ P+ A + P T + +T + L
Sbjct: 1739 QAQSSASVPPLASAPLPPSTSASV---PASTSAPLPATLTPVPASTSAPVPASTLAPVL- 1794
Query: 66 LEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDS 125
S S V P P S S A T A + P +S P+PT + AS S
Sbjct: 1795 ---ASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAP---ASAPAPTPILASVS 1848
Query: 126 PP 127
P
Sbjct: 1849 TP 1850
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 85.1 bits (209), Expect = 2e-16
Identities = 63/238 (26%), Positives = 121/238 (50%), Gaps = 20/238 (8%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREE-QLAREAEARAEREAEARRR 653
++E + L ++ Q ++ RE+EE +R+L AER KR+ ++ + R E + RE EARR+
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQER----- 708
+E+E R + Q E+ E L+++++E E R R E E++R+ERE+ + +++ E ++R
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL 482
Query: 709 -RKRLEE---IMKRTRKSEVSETKQKQDSKEANANGS--SPEPVKAVEARSPGLQ-KEAV 761
++ L+E ++ R+ ++Q ++ + S +PEP E + ++
Sbjct: 483 QQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRF 542
Query: 762 QKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLP 819
+K E Q + L P+P+ E+ + N S +L R E +P
Sbjct: 543 RKTNHSSPEAQSKQTGRVLE-------PPVPSRSESFSNGNSESVHPALQRPAEPQVP 593
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/174 (32%), Positives = 93/174 (53%), Gaps = 17/174 (9%)
Query: 608 RQAREQREREEQERRLQAERDKRMREE-----QLAREAEARAEREAEARRR-EEQEARE- 660
R +E +ER E RR Q +++++RE+ QL E + R E++ E RRR EEQ+ RE
Sbjct: 358 RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRER 417
Query: 661 --KAQAEQEEQERLQKQK---EEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEI 715
+ Q E+E++ R Q++K EE E R +EE ER+R E EK ++ E+E++ R++LEE
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEK--RRVEREQEYIRRQLEE- 474
Query: 716 MKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQ 769
R EV + + Q+ + P P + + P ++ P P+
Sbjct: 475 --EQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPK 526
Score = 57.0 bits (136), Expect = 7e-08
Identities = 52/189 (27%), Positives = 88/189 (46%), Gaps = 25/189 (13%)
Query: 612 EQREREEQERR----LQAERDKRMREEQLAREAEARAEREAEARRR--EEQEARE----K 661
E+ E EQE + + +R + L + E + EA R++ +EQ+ RE K
Sbjct: 329 EEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYK 388
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQER---QERRKRLEEIMKR 718
Q E Q+R+++QKE+ R E+QR ERE QQ+ ++R QE ++RLEE+ +R
Sbjct: 389 RQLLAERQKRIEQQKEQR----RRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 719 TRKSE----VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAV----QKEEPIPQE 770
++ E E K++ + ++ E + +E L +E P PQ
Sbjct: 445 RKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQH 504
Query: 771 PQWSLPSKE 779
Q P ++
Sbjct: 505 SQQPPPPQQ 513
Score = 51.6 bits (122), Expect = 3e-06
Identities = 42/168 (25%), Positives = 84/168 (50%), Gaps = 16/168 (9%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR---REEQEAREK 661
++ R+ R +++ E E E ++ + E++ + E+ RR R +QE +E+
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER 366
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRL-EREKHFQQQEQERQERRKRLEEIMKR-- 718
++A R Q+ +E + R +EE +RQ L ER+K +QQ +E+R+RLEE +R
Sbjct: 367 SEAL-----RRQQLLQEQQLREQEEYKRQLLAERQKRIEQQ----KEQRRRLEEQQRRER 417
Query: 719 -TRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
R+ + E ++++ ++ + E R +K V++E+
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQ 465
Score = 45.8 bits (107), Expect = 2e-04
Identities = 114/508 (22%), Positives = 185/508 (36%), Gaps = 104/508 (20%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAK--ALREKQLQERRRRLEEQRLKAEQRRA 194
ER K ++++E+R + LE++++ + A R+++ ++RRR EE+R E R
Sbjct: 394 ERQKRIEQQKEQRRR---------LEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 195 ALEERQRQKLEKNK---ERYEAAIQRSV--KKTWAEIRQQRWSWAGAL----------HH 239
EE +R++ E+ K ER + I+R + ++ E+ QQ+ A+ H
Sbjct: 445 RKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQH 504
Query: 240 SS--PGHKTSGSRCSVSAVNLPKHVDSIINKR----------------LSKSSATLWNSP 281
S P + S+ S A H + R SK + + P
Sbjct: 505 SQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPP 564
Query: 282 SRNRSLQLSAWESSIV----DRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWG 337
+RS S S V R P + SRS V R+ QG G + G
Sbjct: 565 VPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQA---G 621
Query: 338 RAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAG 397
+ ++ + P+ VP P S S+S + H + +G GER + +
Sbjct: 622 QRNSTSSIEPRLLWERVEKLVP-RPGSGSSSGSSNSGSQPGSHPGSQSGS-GERFRVRSS 679
Query: 398 GSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLS-ASTA 456
+ E SP Q+ E K+ E++KE P P + + A
Sbjct: 680 S-------KSEGSPSQRLENAVKKPEDKKEVFR-------------PLKPAGEVDLTALA 719
Query: 457 SELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKE 516
EL RP T + + GTT V +E A E
Sbjct: 720 KELRAVEDVRPPHKVTDYSSSS-----------------EESGTTDEEDDDV-EQEGADE 761
Query: 517 SPSAAGPED--KSQSKRRASNEKESA--------APASPAPSPAPSPTPAPPQKEQPPAE 566
S S GPED + S ++ E ES + PA +P+ T Q + +
Sbjct: 762 STS--GPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASST 819
Query: 567 TPTDAAVLTSPPAPAPPVTPSKPMAGTT 594
+ + P P + P +GTT
Sbjct: 820 LQKHKSSSSFTPFIDPRLLQISPSSGTT 847
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/90 (27%), Positives = 52/90 (57%), Gaps = 3/90 (3%)
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE---EQRLKAEQRRAALEER 199
+E+ E + + LA ++ +++E+ + L E+Q +ER R + EQR + ++ + LEE
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEEL 441
Query: 200 QRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+R++ E+ + R +R V++ IR+Q
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQ 471
Score = 40.0 bits (92), Expect = 0.009
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 109 PRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE-RAKYLAAKKAVWLEKEEKA 167
P + +PS +S + ++ E KER E R + L ++ + ++E K
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQEN----KERSEALRRQQLLQEQQLREQEEYKR 389
Query: 168 KALREKQLQ-----ERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQR 217
+ L E+Q + E+RRRLEEQ+ + + R E QR++ ++ K R E +R
Sbjct: 390 QLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Score = 37.4 bits (85), Expect = 0.059
Identities = 75/419 (17%), Positives = 155/419 (36%), Gaps = 49/419 (11%)
Query: 387 ERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPAS 446
E +RR+ A +RR E ++ E+ ++ R+ E+E+ E+ +R+
Sbjct: 410 EEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQ-EYI 468
Query: 447 PRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPP-----SPRGTT 501
R E+ + + + HR P P H+ P PP P
Sbjct: 469 RRQLEEEQRHLEVLQQQLLQEQAMLLHDHR------RPHPQHSQQPPPPQQERSKPSFHA 522
Query: 502 ASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKE 561
PK + A+E ED+ + +S E +S P PS + +
Sbjct: 523 PEPKAHYEPADRARE------VEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS-----ES 571
Query: 562 QPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQER 621
+ + L P P PV + + R+ + ++ QA ++ E
Sbjct: 572 FSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 631
Query: 622 RLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEA 681
RL ER +++ + R + + + + ++ + + + R + E + +
Sbjct: 632 RLLWERVEKL----VPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPS 687
Query: 682 RSREEAERQRLEREKHFQ-------------QQEQERQERRKRLEEIMKRTRKSEVSETK 728
+ E A ++ ++++ F+ +E E + ++ + SE S T
Sbjct: 688 QRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTT 747
Query: 729 QKQD----SKEANANGSSPEPVKAVEARS-PGLQKEAVQK---EEPIPQEPQWSLPSKE 779
++D + A+ + S PE +A + + + E+V+ + + EP + PSKE
Sbjct: 748 DEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMT-PSKE 805
Score = 36.2 bits (82), Expect = 0.13
Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 14/127 (11%)
Query: 26 RPSPEGDPSPPPPPMSALVPDTPPDTPPA-MKNATSSKQLP--------LEPESPSGQVG 76
RP P+ PPPP P P A + A ++++ PE+ S Q G
Sbjct: 499 RPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTG 558
Query: 77 P--RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSP--PTKQEV 132
P P S S P P + + P R++ SP + DSP + Q+
Sbjct: 559 RVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSP-VLSRRDSPLQGSGQQN 617
Query: 133 KKAGERH 139
+AG+R+
Sbjct: 618 SQAGQRN 624
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 83.2 bits (204), Expect = 9e-16
Identities = 74/214 (34%), Positives = 105/214 (49%), Gaps = 19/214 (8%)
Query: 570 DAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAE-RD 628
DA V S A V S+ T R+ + L + + Q E E Q R+LQ + R
Sbjct: 96 DANVFASAMMHALEVLNSQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQ 153
Query: 629 KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEA- 687
K + E+L RE R ERE R R E+E E+ + EQE+ ER ++++E E R+E
Sbjct: 154 KELERERLERE---RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERL 210
Query: 688 ERQ-RLEREKHFQQQEQERQERRK--RLEEIMKRTRKSEVSETKQKQDSKE-----ANAN 739
ERQ RLER++ ++ QERQER + RLE + + E E +Q + +E A A
Sbjct: 211 ERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAP 270
Query: 740 GSSPEPVKAV----EARSPGLQKEAVQKEEPIPQ 769
S P+ +V A PGLQ + E P Q
Sbjct: 271 ASVETPLNSVLGDSSASEPGLQAASQPAETPSQQ 304
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/189 (26%), Positives = 94/189 (49%), Gaps = 12/189 (6%)
Query: 630 RMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER 689
R + A+ ++ E E +RR+ QE + + + E+E RL++++ E E RE ER
Sbjct: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE---RLERERMERERLERERLER 178
Query: 690 QRLEREKHFQQQ-EQERQERRKRLEEIMKRTRKSEVSETKQKQDSKE-ANANGSSPEPVK 747
+RLERE+ Q+Q E+ERQER + +E ++R + E E ++Q+ + E ++
Sbjct: 179 ERLERERLEQEQLERERQERER--QERLERQERLERQERLERQERLDRERQERQERERLE 236
Query: 748 AVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGD 807
+E +++ + E + E + + S PAS+ P + G S+ G
Sbjct: 237 RLERERQERERQEQLEREQLEWERERRISSAAAPASV-----ETPLNSVLGDSSASEPGL 291
Query: 808 KSLSRTPET 816
++ S+ ET
Sbjct: 292 QAASQPAET 300
Score = 54.3 bits (129), Expect = 5e-07
Identities = 49/185 (26%), Positives = 71/185 (38%), Gaps = 28/185 (15%)
Query: 412 VQKKEKKDKERENEKEKSALAR-ERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP 470
++++E+ D+ER+ +E+ L R ER ++R+ R +L +S S A P+S
Sbjct: 216 LERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRIS--SAAAPASV 273
Query: 471 STSWHRPASPCPSPGPG---HTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKS 527
T + + PG + P + PS +G P P GP S
Sbjct: 274 ETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLA------PPPPPPLPPGPAQAS 327
Query: 528 QSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPS 587
+ P P P P PS P PP PP P PP P PP P
Sbjct: 328 VAL--------PPPPGPPPPPPLPSTGPPPPP---PPPPLPNQV-----PPPPPPPPAPP 371
Query: 588 KPMAG 592
P +G
Sbjct: 372 LPASG 376
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 25/193 (12%)
Query: 91 AKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKER--REE 148
++ GPT P + P + + PS + +Q+ +K ER +L +ER RE
Sbjct: 113 SQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
Query: 149 RAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ-RLKAEQRRAALE----ERQRQK 203
+ ++ + E+ E+ + RE+Q +ER+ RLE Q RL+ ++R E ERQ ++
Sbjct: 171 LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQ 230
Query: 204 LEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVD 263
+ ER E Q ++ E Q W +S+ P V+
Sbjct: 231 ERERLERLERERQERERQEQLEREQLEWE----------------RERRISSAAAPASVE 274
Query: 264 SIINKRLSKSSAT 276
+ +N L SSA+
Sbjct: 275 TPLNSVLGDSSAS 287
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/194 (24%), Positives = 72/194 (37%), Gaps = 52/194 (26%)
Query: 404 RRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQ------SLPASPRARLSA---- 453
R R E ++ E+ ++ER+ + + L RE+ +R+ + PAS L++
Sbjct: 224 RERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
Query: 454 STASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEE 513
S+ASE ++ ++P+ + P P P PP PP P + +
Sbjct: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPP----PPLPPGPAQASVA---------- 329
Query: 514 AKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV 573
P GP S P P P P P P PP PP
Sbjct: 330 ---LPPPPGPPPPPPLP--------STGPPPP-PPPPPLPNQVPP----PP--------- 364
Query: 574 LTSPPAPAPPVTPS 587
PP PAPP+ S
Sbjct: 365 ---PPPPAPPLPAS 375
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/191 (20%), Positives = 65/191 (34%), Gaps = 21/191 (10%)
Query: 404 RRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKS 463
R R E ++++ ++ + +E + + L R+ L++++ L + R L +
Sbjct: 183 RERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER 242
Query: 464 KARPSSPSTS-----WHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ R W R + P P ++AS G ++ + E+P
Sbjct: 243 QERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG-LQAASQPAETP 301
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPP 578
S G P +P P P P PA PP P L S
Sbjct: 302 SQQGIV---------------LGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTG 346
Query: 579 APAPPVTPSKP 589
P PP P P
Sbjct: 347 PPPPPPPPPLP 357
Score = 39.3 bits (90), Expect = 0.015
Identities = 48/210 (22%), Positives = 75/210 (35%), Gaps = 27/210 (12%)
Query: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLP--LEP 68
+ + P + A + P PS +G P L P PP PP A+ + P P
Sbjct: 285 SASEPGLQAASQPAETPSQQGIVLGP------LAPPPPPPLPPGPAQASVALPPPPGPPP 338
Query: 69 ESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPT 128
P GP P PP P ++ P PP P PP +S ++ + P T
Sbjct: 339 PPPLPSTGPPPPPPPPPLP-----NQVPPPP---PPPPAPPLPASGFFLASMSEDNRPLT 390
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAK---------ALREKQLQERR 179
AG KL K R E + + A+ + L L E
Sbjct: 391 GLAAAIAGA--KLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEM 448
Query: 180 RRLEEQRLKAEQRRAALEERQRQKLEKNKE 209
L +R + ++ + +E Q++ ++ E
Sbjct: 449 SALLARRRRIAEKGSTIETEQKEDKGEDSE 478
Score = 39.3 bits (90), Expect = 0.015
Identities = 21/49 (42%), Positives = 22/49 (44%), Gaps = 2/49 (4%)
Query: 4 GPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTP 52
GP A PP PP P PS P PPPPP+ VP PP P
Sbjct: 322 GPAQASVALPPPP--GPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPP 368
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 83.2 bits (204), Expect = 9e-16
Identities = 74/214 (34%), Positives = 105/214 (49%), Gaps = 19/214 (8%)
Query: 570 DAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAE-RD 628
DA V S A V S+ T R+ + L + + Q E E Q R+LQ + R
Sbjct: 96 DANVFASAMMHALEVLNSQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQ 153
Query: 629 KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEA- 687
K + E+L RE R ERE R R E+E E+ + EQE+ ER ++++E E R+E
Sbjct: 154 KELERERLERE---RMERERLERERLERERLERERLEQEQLERERQERERQERLERQERL 210
Query: 688 ERQ-RLEREKHFQQQEQERQERRK--RLEEIMKRTRKSEVSETKQKQDSKE-----ANAN 739
ERQ RLER++ ++ QERQER + RLE + + E E +Q + +E A A
Sbjct: 211 ERQERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAP 270
Query: 740 GSSPEPVKAV----EARSPGLQKEAVQKEEPIPQ 769
S P+ +V A PGLQ + E P Q
Sbjct: 271 ASVETPLNSVLGDSSASEPGLQAASQPAETPSQQ 304
Score = 62.8 bits (151), Expect = 1e-09
Identities = 51/189 (26%), Positives = 94/189 (49%), Gaps = 12/189 (6%)
Query: 630 RMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAER 689
R + A+ ++ E E +RR+ QE + + + E+E RL++++ E E RE ER
Sbjct: 122 RQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERE---RLERERMERERLERERLER 178
Query: 690 QRLEREKHFQQQ-EQERQERRKRLEEIMKRTRKSEVSETKQKQDSKE-ANANGSSPEPVK 747
+RLERE+ Q+Q E+ERQER + +E ++R + E E ++Q+ + E ++
Sbjct: 179 ERLERERLEQEQLERERQERER--QERLERQERLERQERLERQERLDRERQERQERERLE 236
Query: 748 AVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGD 807
+E +++ + E + E + + S PAS+ P + G S+ G
Sbjct: 237 RLERERQERERQEQLEREQLEWERERRISSAAAPASV-----ETPLNSVLGDSSASEPGL 291
Query: 808 KSLSRTPET 816
++ S+ ET
Sbjct: 292 QAASQPAET 300
Score = 54.3 bits (129), Expect = 5e-07
Identities = 49/185 (26%), Positives = 71/185 (38%), Gaps = 28/185 (15%)
Query: 412 VQKKEKKDKERENEKEKSALAR-ERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP 470
++++E+ D+ER+ +E+ L R ER ++R+ R +L +S S A P+S
Sbjct: 216 LERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRIS--SAAAPASV 273
Query: 471 STSWHRPASPCPSPGPG---HTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKS 527
T + + PG + P + PS +G P P GP S
Sbjct: 274 ETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLA------PPPPPPLPPGPAQAS 327
Query: 528 QSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPS 587
+ P P P P PS P PP PP P PP P PP P
Sbjct: 328 VAL--------PPPPGPPPPPPLPSTGPPPPP---PPPPLPNQV-----PPPPPPPPAPP 371
Query: 588 KPMAG 592
P +G
Sbjct: 372 LPASG 376
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 25/193 (12%)
Query: 91 AKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKER--REE 148
++ GPT P + P + + PS + +Q+ +K ER +L +ER RE
Sbjct: 113 SQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERMERER 170
Query: 149 RAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ-RLKAEQRRAALE----ERQRQK 203
+ ++ + E+ E+ + RE+Q +ER+ RLE Q RL+ ++R E ERQ ++
Sbjct: 171 LERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQ 230
Query: 204 LEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVD 263
+ ER E Q ++ E Q W +S+ P V+
Sbjct: 231 ERERLERLERERQERERQEQLEREQLEWE----------------RERRISSAAAPASVE 274
Query: 264 SIINKRLSKSSAT 276
+ +N L SSA+
Sbjct: 275 TPLNSVLGDSSAS 287
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/194 (24%), Positives = 72/194 (37%), Gaps = 52/194 (26%)
Query: 404 RRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQ------SLPASPRARLSA---- 453
R R E ++ E+ ++ER+ + + L RE+ +R+ + PAS L++
Sbjct: 224 RERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGD 283
Query: 454 STASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEE 513
S+ASE ++ ++P+ + P P P PP PP P + +
Sbjct: 284 SSASEPGLQAASQPAETPSQQGIVLGPLAPPPP----PPLPPGPAQASVA---------- 329
Query: 514 AKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAV 573
P GP S P P P P P P PP PP
Sbjct: 330 ---LPPPPGPPPPPPLP--------STGPPPP-PPPPPLPNQVPP----PP--------- 364
Query: 574 LTSPPAPAPPVTPS 587
PP PAPP+ S
Sbjct: 365 ---PPPPAPPLPAS 375
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/191 (20%), Positives = 65/191 (34%), Gaps = 21/191 (10%)
Query: 404 RRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKS 463
R R E ++++ ++ + +E + + L R+ L++++ L + R L +
Sbjct: 183 RERLEQEQLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERER 242
Query: 464 KARPSSPSTS-----WHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ R W R + P P ++AS G ++ + E+P
Sbjct: 243 QERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPG-LQAASQPAETP 301
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPP 578
S G P +P P P P PA PP P L S
Sbjct: 302 SQQGIV---------------LGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTG 346
Query: 579 APAPPVTPSKP 589
P PP P P
Sbjct: 347 PPPPPPPPPLP 357
Score = 39.3 bits (90), Expect = 0.015
Identities = 48/210 (22%), Positives = 75/210 (35%), Gaps = 27/210 (12%)
Query: 11 AGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLP--LEP 68
+ + P + A + P PS +G P L P PP PP A+ + P P
Sbjct: 285 SASEPGLQAASQPAETPSQQGIVLGP------LAPPPPPPLPPGPAQASVALPPPPGPPP 338
Query: 69 ESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPT 128
P GP P PP P ++ P PP P PP +S ++ + P T
Sbjct: 339 PPPLPSTGPPPPPPPPPLP-----NQVPPPP---PPPPAPPLPASGFFLASMSEDNRPLT 390
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAK---------ALREKQLQERR 179
AG KL K R E + + A+ + L L E
Sbjct: 391 GLAAAIAGA--KLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLMEEM 448
Query: 180 RRLEEQRLKAEQRRAALEERQRQKLEKNKE 209
L +R + ++ + +E Q++ ++ E
Sbjct: 449 SALLARRRRIAEKGSTIETEQKEDKGEDSE 478
Score = 39.3 bits (90), Expect = 0.015
Identities = 21/49 (42%), Positives = 22/49 (44%), Gaps = 2/49 (4%)
Query: 4 GPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTP 52
GP A PP PP P PS P PPPPP+ VP PP P
Sbjct: 322 GPAQASVALPPPP--GPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPP 368
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 83.2 bits (204), Expect = 9e-16
Identities = 76/249 (30%), Positives = 123/249 (49%), Gaps = 32/249 (12%)
Query: 562 QPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQER 621
QP A PT + P TP + E+ +L EK + A+ ++ER E E
Sbjct: 689 QPTASQPTVWEGGSVWDLPLDTTTPGPAL------EQLQQL--EKAKAAKLEQERREAEM 740
Query: 622 RLQAERDKRMREEQLAREAEA--RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEA 679
R + E ++R R+E+L R+ E R ++E E +RREE+E A+ +QEE R Q+++E A
Sbjct: 741 RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL---ARRKQEEALRRQREQEIA 797
Query: 680 EARSREEAERQRLERE-KHFQQQEQERQER-------RKRLEEIMKRTRKSEVSETKQKQ 731
R REE ERQ+ E + +++ +E +ER RK+ EE K R+ E ++ + ++
Sbjct: 798 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 857
Query: 732 D----SKEANANGSSPEPVKAVE---ARSPGLQKEAVQKEEPI----PQEPQWSLPSKEL 780
+ +EA E K E R L ++ Q++E + Q+ Q L +L
Sbjct: 858 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 917
Query: 781 PASLVNGLQ 789
P+S G Q
Sbjct: 918 PSSSTWGQQ 926
Score = 72.0 bits (175), Expect = 2e-12
Identities = 64/241 (26%), Positives = 116/241 (48%), Gaps = 31/241 (12%)
Query: 596 REEATRLLAEKR---RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
+EEA R E+ R+ RE+ ER++QE L+ R E+ RE E R ++E E R
Sbjct: 784 QEEALRRQREQEIALRRQREEEERQQQEEALR-------RLEERRREEEERRKQE-ELLR 835
Query: 653 REEQEAREKAQAEQEEQERLQ----KQKEEAEARSREEAERQR----LEREKHFQQQEQE 704
++E+EA + A+ E+E Q RL+ + +EEA EE ER+R ++R+K +Q Q+
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895
Query: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE 764
+QE +RL++ ++ + +++ +++N + ++ +QK ++E
Sbjct: 896 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE----IQKLEEERE 951
Query: 765 EPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAE 824
+ +E + L+ LQ Q+ S G S T ++LL + E
Sbjct: 952 RQLREE------QRRQQRELMKALQQQQQQQQQKLS--GWGNVSKPSGTTKSLLEIQQEE 1003
Query: 825 A 825
A
Sbjct: 1004 A 1004
Score = 71.2 bits (173), Expect = 4e-12
Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 32/214 (14%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR----EAEARAEREAEAR 651
+EEA R L E+RR+ E+R++EE R+ + E K REE+ A+ E R E EA
Sbjct: 810 QEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARL 869
Query: 652 RREEQEAREKAQAEQEEQE--RLQKQKEEAEARSREEAERQRLEREK------------- 696
R EE+E + K Q ++E R ++Q++EA R +++ ++Q+L + K
Sbjct: 870 RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNT 929
Query: 697 ------------HFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744
Q+ E+ER ER+ R E+ ++ + + +Q+Q ++ + G+ +
Sbjct: 930 TACQSQATLSLAEIQKLEEER-ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSK 988
Query: 745 PVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
P ++ Q+EA Q ++ Q+ Q P++
Sbjct: 989 PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1022
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 28/201 (13%)
Query: 36 PPPPMSALVPDT-------PPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPS 88
P S VPDT P + P + S LPL+ +P GP Q+ +
Sbjct: 671 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP----GPALEQLQQLEKA 726
Query: 89 SEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE 148
AK A + R R + K++ + ++ ++ + ++EE
Sbjct: 727 KAAKLEQERREA----EMRAKREEEE-------------RKRQEELRRQQEEILRRQQEE 769
Query: 149 RAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208
K ++ ++EE + RE+++ RR+R EE+R + E+ LEER+R++ E+ K
Sbjct: 770 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 829
Query: 209 ERYEAAIQRSVKKTWAEIRQQ 229
+ Q WA ++
Sbjct: 830 QEELLRKQEEEAAKWAREEEE 850
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/135 (27%), Positives = 72/135 (53%), Gaps = 10/135 (7%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E ++ E + +ERR E + ++ + ++EE AK RE++ E +RRLEE RL+
Sbjct: 804 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLR 861
Query: 189 AEQRRAAL----EERQRQKLEKNKE----RYEAAIQRSVKKTWAEIRQQRWSWAGALHHS 240
E+ A L EER+R++LE ++ R Q ++++ + +QQ+ + S
Sbjct: 862 MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSS 921
Query: 241 SPGHKTSGSRCSVSA 255
+ G +++ + C A
Sbjct: 922 TWGQQSNTTACQSQA 936
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/179 (22%), Positives = 69/179 (38%), Gaps = 13/179 (7%)
Query: 400 PAPVRRRPEASPVQKKEK-KDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASE 458
P P + + PV + E+ D E + +E A+E ++ + R + AS +
Sbjct: 310 PIPEEQEMDFRPVDEGEECSDSEGSHNEE----AKEPDKTNKKEGEKTDRVGVEASEETP 365
Query: 459 LSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ S ARP +PS + AS +P + + A + R+ AK P
Sbjct: 366 QTSSSSARPGTPSDHQSQEASQFERKD-------EPKTEQTEKAEEETRMENSLPAKV-P 417
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSP 577
S + + ++A+P P P P+P+P E P P +V T P
Sbjct: 418 SRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEP 476
Score = 37.0 bits (84), Expect = 0.076
Identities = 27/114 (23%), Positives = 58/114 (50%), Gaps = 14/114 (12%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+ E + A RH+ +E R+ + + +K + +++++ +ALR Q Q+++++L + +L
Sbjct: 861 RMEEEAARLRHE--EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 918
Query: 189 AE------------QRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ Q +A L + QKLE+ +ER QR ++ + QQ+
Sbjct: 919 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 972
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 593 TTDREEATRLLAE--KRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
T + +AT LAE K + RE++ REEQ RR Q E K ++++Q ++ +
Sbjct: 930 TACQSQATLSLAEIQKLEEERERQLREEQ-RRQQRELMKALQQQQQQQQQKLSGWGNVS- 987
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKH 697
+ + + +QEE ++QKQ+++ + + R H
Sbjct: 988 --KPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1032
Score = 30.8 bits (68), Expect = 5.5
Identities = 16/44 (36%), Positives = 31/44 (70%), Gaps = 3/44 (6%)
Query: 161 LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKL 204
L + +K + RE+QL+E +RR + + +KA Q++ +++Q+QKL
Sbjct: 940 LAEIQKLEEERERQLREEQRRQQRELMKALQQQ---QQQQQQKL 980
Score = 30.4 bits (67), Expect = 7.2
Identities = 40/175 (22%), Positives = 63/175 (36%), Gaps = 20/175 (11%)
Query: 607 RRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQ 666
R R Q E +RR + K + R+ E R E + R + +
Sbjct: 153 REMHRSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQN 212
Query: 667 EEQE----RLQKQKEEAEA-RSREEAERQRLEREKHFQ----QQEQERQERRKRLEEIMK 717
E E RL + + E R R+ +ER + F+ ++ ER RR R
Sbjct: 213 GEDEDGGWRLAGSRRDGERWRPHSPGWREHMERRRRFEFDFRDRDDERGYRRVR------ 266
Query: 718 RTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
S +DS + E + ++ L + VQK EPIP+E +
Sbjct: 267 ----SGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQK-EPIPEEQE 316
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 83.2 bits (204), Expect = 9e-16
Identities = 76/249 (30%), Positives = 123/249 (49%), Gaps = 32/249 (12%)
Query: 562 QPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQER 621
QP A PT + P TP + E+ +L EK + A+ ++ER E E
Sbjct: 716 QPTASQPTVWEGGSVWDLPLDTTTPGPAL------EQLQQL--EKAKAAKLEQERREAEM 767
Query: 622 RLQAERDKRMREEQLAREAEA--RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEA 679
R + E ++R R+E+L R+ E R ++E E +RREE+E A+ +QEE R Q+++E A
Sbjct: 768 RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL---ARRKQEEALRRQREQEIA 824
Query: 680 EARSREEAERQRLERE-KHFQQQEQERQER-------RKRLEEIMKRTRKSEVSETKQKQ 731
R REE ERQ+ E + +++ +E +ER RK+ EE K R+ E ++ + ++
Sbjct: 825 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 884
Query: 732 D----SKEANANGSSPEPVKAVE---ARSPGLQKEAVQKEEPI----PQEPQWSLPSKEL 780
+ +EA E K E R L ++ Q++E + Q+ Q L +L
Sbjct: 885 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 944
Query: 781 PASLVNGLQ 789
P+S G Q
Sbjct: 945 PSSSTWGQQ 953
Score = 72.0 bits (175), Expect = 2e-12
Identities = 64/241 (26%), Positives = 116/241 (48%), Gaps = 31/241 (12%)
Query: 596 REEATRLLAEKR---RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
+EEA R E+ R+ RE+ ER++QE L+ R E+ RE E R ++E E R
Sbjct: 811 QEEALRRQREQEIALRRQREEEERQQQEEALR-------RLEERRREEEERRKQE-ELLR 862
Query: 653 REEQEAREKAQAEQEEQERLQ----KQKEEAEARSREEAERQR----LEREKHFQQQEQE 704
++E+EA + A+ E+E Q RL+ + +EEA EE ER+R ++R+K +Q Q+
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922
Query: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE 764
+QE +RL++ ++ + +++ +++N + ++ +QK ++E
Sbjct: 923 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE----IQKLEEERE 978
Query: 765 EPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAE 824
+ +E + L+ LQ Q+ S G S T ++LL + E
Sbjct: 979 RQLREE------QRRQQRELMKALQQQQQQQQQKLS--GWGNVSKPSGTTKSLLEIQQEE 1030
Query: 825 A 825
A
Sbjct: 1031 A 1031
Score = 71.2 bits (173), Expect = 4e-12
Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 32/214 (14%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR----EAEARAEREAEAR 651
+EEA R L E+RR+ E+R++EE R+ + E K REE+ A+ E R E EA
Sbjct: 837 QEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARL 896
Query: 652 RREEQEAREKAQAEQEEQE--RLQKQKEEAEARSREEAERQRLEREK------------- 696
R EE+E + K Q ++E R ++Q++EA R +++ ++Q+L + K
Sbjct: 897 RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNT 956
Query: 697 ------------HFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744
Q+ E+ER ER+ R E+ ++ + + +Q+Q ++ + G+ +
Sbjct: 957 TACQSQATLSLAEIQKLEEER-ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSK 1015
Query: 745 PVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
P ++ Q+EA Q ++ Q+ Q P++
Sbjct: 1016 PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1049
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 28/201 (13%)
Query: 36 PPPPMSALVPDT-------PPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPS 88
P S VPDT P + P + S LPL+ +P GP Q+ +
Sbjct: 698 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP----GPALEQLQQLEKA 753
Query: 89 SEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE 148
AK A + R R + K++ + ++ ++ + ++EE
Sbjct: 754 KAAKLEQERREA----EMRAKREEEE-------------RKRQEELRRQQEEILRRQQEE 796
Query: 149 RAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208
K ++ ++EE + RE+++ RR+R EE+R + E+ LEER+R++ E+ K
Sbjct: 797 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 856
Query: 209 ERYEAAIQRSVKKTWAEIRQQ 229
+ Q WA ++
Sbjct: 857 QEELLRKQEEEAAKWAREEEE 877
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/135 (27%), Positives = 72/135 (53%), Gaps = 10/135 (7%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E ++ E + +ERR E + ++ + ++EE AK RE++ E +RRLEE RL+
Sbjct: 831 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLR 888
Query: 189 AEQRRAAL----EERQRQKLEKNKE----RYEAAIQRSVKKTWAEIRQQRWSWAGALHHS 240
E+ A L EER+R++LE ++ R Q ++++ + +QQ+ + S
Sbjct: 889 MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSS 948
Query: 241 SPGHKTSGSRCSVSA 255
+ G +++ + C A
Sbjct: 949 TWGQQSNTTACQSQA 963
Score = 37.0 bits (84), Expect = 0.076
Identities = 27/114 (23%), Positives = 58/114 (50%), Gaps = 14/114 (12%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+ E + A RH+ +E R+ + + +K + +++++ +ALR Q Q+++++L + +L
Sbjct: 888 RMEEEAARLRHE--EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 945
Query: 189 AE------------QRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ Q +A L + QKLE+ +ER QR ++ + QQ+
Sbjct: 946 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 999
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 593 TTDREEATRLLAE--KRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
T + +AT LAE K + RE++ REEQ RR Q E K ++++Q ++ +
Sbjct: 957 TACQSQATLSLAEIQKLEEERERQLREEQ-RRQQRELMKALQQQQQQQQQKLSGWGNVS- 1014
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKH 697
+ + + +QEE ++QKQ+++ + + R H
Sbjct: 1015 --KPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1059
Score = 35.8 bits (81), Expect = 0.17
Identities = 40/179 (22%), Positives = 69/179 (38%), Gaps = 14/179 (7%)
Query: 400 PAPVRRRPEASPVQKKEK-KDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASE 458
P P + + PV + E+ D E + +E A+E ++ + R +++ +
Sbjct: 338 PIPEEQEMDFRPVDEGEECSDSEGSHNEE----AKEPDKTNKKEGEKTDRVGVASEETPQ 393
Query: 459 LSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
S S ARP +PS + AS +P + + A + R+ AK P
Sbjct: 394 TS-SSSARPGTPSDHQSQEASQFERKD-------EPKTEQTEKAEEETRMENSLPAKV-P 444
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSP 577
S + + ++A+P P P P+P+P E P P +V T P
Sbjct: 445 SRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEP 503
Score = 30.8 bits (68), Expect = 5.5
Identities = 16/44 (36%), Positives = 31/44 (70%), Gaps = 3/44 (6%)
Query: 161 LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKL 204
L + +K + RE+QL+E +RR + + +KA Q++ +++Q+QKL
Sbjct: 967 LAEIQKLEEERERQLREEQRRQQRELMKALQQQ---QQQQQQKL 1007
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 83.2 bits (204), Expect = 9e-16
Identities = 76/249 (30%), Positives = 123/249 (49%), Gaps = 32/249 (12%)
Query: 562 QPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQER 621
QP A PT + P TP + E+ +L EK + A+ ++ER E E
Sbjct: 695 QPTASQPTVWEGGSVWDLPLDTTTPGPAL------EQLQQL--EKAKAAKLEQERREAEM 746
Query: 622 RLQAERDKRMREEQLAREAEA--RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEA 679
R + E ++R R+E+L R+ E R ++E E +RREE+E A+ +QEE R Q+++E A
Sbjct: 747 RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL---ARRKQEEALRRQREQEIA 803
Query: 680 EARSREEAERQRLERE-KHFQQQEQERQER-------RKRLEEIMKRTRKSEVSETKQKQ 731
R REE ERQ+ E + +++ +E +ER RK+ EE K R+ E ++ + ++
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 732 D----SKEANANGSSPEPVKAVE---ARSPGLQKEAVQKEEPI----PQEPQWSLPSKEL 780
+ +EA E K E R L ++ Q++E + Q+ Q L +L
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Query: 781 PASLVNGLQ 789
P+S G Q
Sbjct: 924 PSSSTWGQQ 932
Score = 72.0 bits (175), Expect = 2e-12
Identities = 64/241 (26%), Positives = 116/241 (48%), Gaps = 31/241 (12%)
Query: 596 REEATRLLAEKR---RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
+EEA R E+ R+ RE+ ER++QE L+ R E+ RE E R ++E E R
Sbjct: 790 QEEALRRQREQEIALRRQREEEERQQQEEALR-------RLEERRREEEERRKQE-ELLR 841
Query: 653 REEQEAREKAQAEQEEQERLQ----KQKEEAEARSREEAERQR----LEREKHFQQQEQE 704
++E+EA + A+ E+E Q RL+ + +EEA EE ER+R ++R+K +Q Q+
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE 764
+QE +RL++ ++ + +++ +++N + ++ +QK ++E
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE----IQKLEEERE 957
Query: 765 EPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAE 824
+ +E + L+ LQ Q+ S G S T ++LL + E
Sbjct: 958 RQLREE------QRRQQRELMKALQQQQQQQQQKLS--GWGNVSKPSGTTKSLLEIQQEE 1009
Query: 825 A 825
A
Sbjct: 1010 A 1010
Score = 71.2 bits (173), Expect = 4e-12
Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 32/214 (14%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR----EAEARAEREAEAR 651
+EEA R L E+RR+ E+R++EE R+ + E K REE+ A+ E R E EA
Sbjct: 816 QEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARL 875
Query: 652 RREEQEAREKAQAEQEEQE--RLQKQKEEAEARSREEAERQRLEREK------------- 696
R EE+E + K Q ++E R ++Q++EA R +++ ++Q+L + K
Sbjct: 876 RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNT 935
Query: 697 ------------HFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744
Q+ E+ER ER+ R E+ ++ + + +Q+Q ++ + G+ +
Sbjct: 936 TACQSQATLSLAEIQKLEEER-ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSK 994
Query: 745 PVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
P ++ Q+EA Q ++ Q+ Q P++
Sbjct: 995 PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1028
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 28/201 (13%)
Query: 36 PPPPMSALVPDT-------PPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPS 88
P S VPDT P + P + S LPL+ +P GP Q+ +
Sbjct: 677 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP----GPALEQLQQLEKA 732
Query: 89 SEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE 148
AK A + R R + K++ + ++ ++ + ++EE
Sbjct: 733 KAAKLEQERREA----EMRAKREEEE-------------RKRQEELRRQQEEILRRQQEE 775
Query: 149 RAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208
K ++ ++EE + RE+++ RR+R EE+R + E+ LEER+R++ E+ K
Sbjct: 776 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 835
Query: 209 ERYEAAIQRSVKKTWAEIRQQ 229
+ Q WA ++
Sbjct: 836 QEELLRKQEEEAAKWAREEEE 856
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/135 (27%), Positives = 72/135 (53%), Gaps = 10/135 (7%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E ++ E + +ERR E + ++ + ++EE AK RE++ E +RRLEE RL+
Sbjct: 810 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLR 867
Query: 189 AEQRRAAL----EERQRQKLEKNKE----RYEAAIQRSVKKTWAEIRQQRWSWAGALHHS 240
E+ A L EER+R++LE ++ R Q ++++ + +QQ+ + S
Sbjct: 868 MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSS 927
Query: 241 SPGHKTSGSRCSVSA 255
+ G +++ + C A
Sbjct: 928 TWGQQSNTTACQSQA 942
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/179 (22%), Positives = 69/179 (38%), Gaps = 13/179 (7%)
Query: 400 PAPVRRRPEASPVQKKEK-KDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASE 458
P P + + PV + E+ D E + +E A+E ++ + R + AS +
Sbjct: 316 PIPEEQEMDFRPVDEGEECSDSEGSHNEE----AKEPDKTNKKEGEKTDRVGVEASEETP 371
Query: 459 LSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ S ARP +PS + AS +P + + A + R+ AK P
Sbjct: 372 QTSSSSARPGTPSDHQSQEASQFERKD-------EPKTEQTEKAEEETRMENSLPAKV-P 423
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSP 577
S + + ++A+P P P P+P+P E P P +V T P
Sbjct: 424 SRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEP 482
Score = 37.0 bits (84), Expect = 0.076
Identities = 27/114 (23%), Positives = 58/114 (50%), Gaps = 14/114 (12%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+ E + A RH+ +E R+ + + +K + +++++ +ALR Q Q+++++L + +L
Sbjct: 867 RMEEEAARLRHE--EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 924
Query: 189 AE------------QRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ Q +A L + QKLE+ +ER QR ++ + QQ+
Sbjct: 925 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 978
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 593 TTDREEATRLLAE--KRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
T + +AT LAE K + RE++ REEQ RR Q E K ++++Q ++ +
Sbjct: 936 TACQSQATLSLAEIQKLEEERERQLREEQ-RRQQRELMKALQQQQQQQQQKLSGWGNVS- 993
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKH 697
+ + + +QEE ++QKQ+++ + + R H
Sbjct: 994 --KPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038
Score = 30.8 bits (68), Expect = 5.5
Identities = 16/44 (36%), Positives = 31/44 (70%), Gaps = 3/44 (6%)
Query: 161 LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKL 204
L + +K + RE+QL+E +RR + + +KA Q++ +++Q+QKL
Sbjct: 946 LAEIQKLEEERERQLREEQRRQQRELMKALQQQ---QQQQQQKL 986
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 83.2 bits (204), Expect = 9e-16
Identities = 76/249 (30%), Positives = 123/249 (49%), Gaps = 32/249 (12%)
Query: 562 QPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQER 621
QP A PT + P TP + E+ +L EK + A+ ++ER E E
Sbjct: 695 QPTASQPTVWEGGSVWDLPLDTTTPGPAL------EQLQQL--EKAKAAKLEQERREAEM 746
Query: 622 RLQAERDKRMREEQLAREAEA--RAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEA 679
R + E ++R R+E+L R+ E R ++E E +RREE+E A+ +QEE R Q+++E A
Sbjct: 747 RAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEEL---ARRKQEEALRRQREQEIA 803
Query: 680 EARSREEAERQRLERE-KHFQQQEQERQER-------RKRLEEIMKRTRKSEVSETKQKQ 731
R REE ERQ+ E + +++ +E +ER RK+ EE K R+ E ++ + ++
Sbjct: 804 LRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEE 863
Query: 732 D----SKEANANGSSPEPVKAVE---ARSPGLQKEAVQKEEPI----PQEPQWSLPSKEL 780
+ +EA E K E R L ++ Q++E + Q+ Q L +L
Sbjct: 864 NRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKL 923
Query: 781 PASLVNGLQ 789
P+S G Q
Sbjct: 924 PSSSTWGQQ 932
Score = 72.0 bits (175), Expect = 2e-12
Identities = 64/241 (26%), Positives = 116/241 (48%), Gaps = 31/241 (12%)
Query: 596 REEATRLLAEKR---RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
+EEA R E+ R+ RE+ ER++QE L+ R E+ RE E R ++E E R
Sbjct: 790 QEEALRRQREQEIALRRQREEEERQQQEEALR-------RLEERRREEEERRKQE-ELLR 841
Query: 653 REEQEAREKAQAEQEEQERLQ----KQKEEAEARSREEAERQR----LEREKHFQQQEQE 704
++E+EA + A+ E+E Q RL+ + +EEA EE ER+R ++R+K +Q Q+
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901
Query: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE 764
+QE +RL++ ++ + +++ +++N + ++ +QK ++E
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAE----IQKLEEERE 957
Query: 765 EPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAEAE 824
+ +E + L+ LQ Q+ S G S T ++LL + E
Sbjct: 958 RQLREE------QRRQQRELMKALQQQQQQQQQKLS--GWGNVSKPSGTTKSLLEIQQEE 1009
Query: 825 A 825
A
Sbjct: 1010 A 1010
Score = 71.2 bits (173), Expect = 4e-12
Identities = 58/214 (27%), Positives = 106/214 (49%), Gaps = 32/214 (14%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR----EAEARAEREAEAR 651
+EEA R L E+RR+ E+R++EE R+ + E K REE+ A+ E R E EA
Sbjct: 816 QEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARL 875
Query: 652 RREEQEAREKAQAEQEEQE--RLQKQKEEAEARSREEAERQRLEREK------------- 696
R EE+E + K Q ++E R ++Q++EA R +++ ++Q+L + K
Sbjct: 876 RHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNT 935
Query: 697 ------------HFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744
Q+ E+ER ER+ R E+ ++ + + +Q+Q ++ + G+ +
Sbjct: 936 TACQSQATLSLAEIQKLEEER-ERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSK 994
Query: 745 PVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
P ++ Q+EA Q ++ Q+ Q P++
Sbjct: 995 PSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1028
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/201 (22%), Positives = 83/201 (41%), Gaps = 28/201 (13%)
Query: 36 PPPPMSALVPDT-------PPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPS 88
P S VPDT P + P + S LPL+ +P GP Q+ +
Sbjct: 677 PSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTP----GPALEQLQQLEKA 732
Query: 89 SEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE 148
AK A + R R + K++ + ++ ++ + ++EE
Sbjct: 733 KAAKLEQERREA----EMRAKREEEE-------------RKRQEELRRQQEEILRRQQEE 775
Query: 149 RAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNK 208
K ++ ++EE + RE+++ RR+R EE+R + E+ LEER+R++ E+ K
Sbjct: 776 ERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRK 835
Query: 209 ERYEAAIQRSVKKTWAEIRQQ 229
+ Q WA ++
Sbjct: 836 QEELLRKQEEEAAKWAREEEE 856
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/135 (27%), Positives = 72/135 (53%), Gaps = 10/135 (7%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E ++ E + +ERR E + ++ + ++EE AK RE++ E +RRLEE RL+
Sbjct: 810 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEE--EAQRRLEENRLR 867
Query: 189 AEQRRAAL----EERQRQKLEKNKE----RYEAAIQRSVKKTWAEIRQQRWSWAGALHHS 240
E+ A L EER+R++LE ++ R Q ++++ + +QQ+ + S
Sbjct: 868 MEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSS 927
Query: 241 SPGHKTSGSRCSVSA 255
+ G +++ + C A
Sbjct: 928 TWGQQSNTTACQSQA 942
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/179 (22%), Positives = 69/179 (38%), Gaps = 13/179 (7%)
Query: 400 PAPVRRRPEASPVQKKEK-KDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASE 458
P P + + PV + E+ D E + +E A+E ++ + R + AS +
Sbjct: 316 PIPEEQEMDFRPVDEGEECSDSEGSHNEE----AKEPDKTNKKEGEKTDRVGVEASEETP 371
Query: 459 LSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ S ARP +PS + AS +P + + A + R+ AK P
Sbjct: 372 QTSSSSARPGTPSDHQSQEASQFERKD-------EPKTEQTEKAEEETRMENSLPAKV-P 423
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSP 577
S + + ++A+P P P P+P+P E P P +V T P
Sbjct: 424 SRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEP 482
Score = 37.0 bits (84), Expect = 0.076
Identities = 27/114 (23%), Positives = 58/114 (50%), Gaps = 14/114 (12%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+ E + A RH+ +E R+ + + +K + +++++ +ALR Q Q+++++L + +L
Sbjct: 867 RMEEEAARLRHE--EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLP 924
Query: 189 AE------------QRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ Q +A L + QKLE+ +ER QR ++ + QQ+
Sbjct: 925 SSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQ 978
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 593 TTDREEATRLLAE--KRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
T + +AT LAE K + RE++ REEQ RR Q E K ++++Q ++ +
Sbjct: 936 TACQSQATLSLAEIQKLEEERERQLREEQ-RRQQRELMKALQQQQQQQQQKLSGWGNVS- 993
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKH 697
+ + + +QEE ++QKQ+++ + + R H
Sbjct: 994 --KPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLH 1038
Score = 30.8 bits (68), Expect = 5.5
Identities = 16/44 (36%), Positives = 31/44 (70%), Gaps = 3/44 (6%)
Query: 161 LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKL 204
L + +K + RE+QL+E +RR + + +KA Q++ +++Q+QKL
Sbjct: 946 LAEIQKLEEERERQLREEQRRQQRELMKALQQQ---QQQQQQKL 986
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 83.2 bits (204), Expect = 9e-16
Identities = 50/192 (26%), Positives = 101/192 (52%), Gaps = 5/192 (2%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREE-QLAREAEARAEREAEARRR 653
++E + L ++ Q ++ RE+EE +R+L AER KR+ ++ + R E + RE EARR+
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713
+E+E R + Q E+ E L+++++E E R R E E++R+ERE+ + +++ E ++R +
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVL 482
Query: 714 EIMKRTRKSEVSETKQKQDSKEANA----NGSSPEPVKAVEARSPGLQKEAVQKEEPIPQ 769
+ ++ + E + ++ + A E + + + ++P P
Sbjct: 483 QQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPP 542
Query: 770 EPQWSLPSKELP 781
+ + S PS P
Sbjct: 543 QQERSKPSFHAP 554
Score = 70.5 bits (171), Expect = 6e-12
Identities = 48/119 (40%), Positives = 75/119 (63%), Gaps = 14/119 (11%)
Query: 608 RQAREQREREEQERRLQAERDKRMREE-----QLAREAEARAEREAEARRR-EEQEARE- 660
R +E +ER E RR Q +++++RE+ QL E + R E++ E RRR EEQ+ RE
Sbjct: 358 RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRER 417
Query: 661 --KAQAEQEEQERLQKQK---EEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
+ Q E+E++ R Q++K EE E R +EE ER+R E EK ++ E+E++ R++LEE
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEK--RRVEREQEYIRRQLEE 474
Score = 64.3 bits (155), Expect = 4e-10
Identities = 72/248 (29%), Positives = 108/248 (43%), Gaps = 49/248 (19%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEA---RAEREAEARRR 653
E+ R +R+Q REQR RE++E+R E ++R +EE+ R AE R ERE E RR
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRR 470
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSR-----EEAER--QRLERE----------- 695
+ +E E+ E +Q+ LQ+Q E R R +AER ++L++E
Sbjct: 471 QLEE--EQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDH 528
Query: 696 -----KHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE------ 744
+H QQ +QER K + E ++ ++ + + N SSPE
Sbjct: 529 RRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQT 588
Query: 745 ------PVKAVEARSPGLQKEAVQKEEPIPQEP--QWSLPSKELPASLVNGLQPLPAHQE 796
PV + E+V P EP QWS ASL N + P+ +
Sbjct: 589 GRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVQWS-----HLASLKNNVSPV--SRS 641
Query: 797 NGFSTNGP 804
+ FS P
Sbjct: 642 HSFSDPSP 649
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/189 (25%), Positives = 96/189 (50%), Gaps = 10/189 (5%)
Query: 615 EREEQERRLQAERDKRMREEQLAREAEARAEREAEARRR-EEQEAREKAQAEQEEQERLQ 673
++E +ER R + ++E+QL + E + + AE ++R E+Q+ + + EQ+ +ER
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 674 KQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEV--SETKQKQ 731
++++E E R RE+ E++RLE +++ +E +ERR+ EE + R+ E + +++Q
Sbjct: 420 RRQQEREQRRREQEEKRRLE---ELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQ 476
Query: 732 DSKEANANGSSPEPVKAVEARSPGLQ--KEAVQKEEPIPQEPQW--SLPSKELPASLVNG 787
E E +E R ++ ++A + + + QE + SL +
Sbjct: 477 RHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHS 536
Query: 788 LQPLPAHQE 796
QP P QE
Sbjct: 537 QQPPPPQQE 545
Score = 55.8 bits (133), Expect = 2e-07
Identities = 48/175 (27%), Positives = 85/175 (48%), Gaps = 18/175 (10%)
Query: 612 EQREREEQERR----LQAERDKRMREEQLAREAEARAEREAEARRR--EEQEARE----K 661
E+ E EQE + + +R + L + E + EA R++ +EQ+ RE K
Sbjct: 329 EEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYK 388
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQER---QERRKRLEEIMKR 718
Q E Q+R+++QKE+ R E+QR ERE QQ+ ++R QE ++RLEE ++R
Sbjct: 389 RQLLAERQKRIEQQKEQR----RRLEEQQRREREARRQQEREQRRREQEEKRRLEE-LER 443
Query: 719 TRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQW 773
RK E + +++ + E R + ++ + +E+ + E +W
Sbjct: 444 RRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRW 498
Score = 51.6 bits (122), Expect = 3e-06
Identities = 42/168 (25%), Positives = 84/168 (50%), Gaps = 16/168 (9%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR---REEQEAREK 661
++ R+ R +++ E E E ++ + E++ + E+ RR R +QE +E+
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER 366
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRL-EREKHFQQQEQERQERRKRLEEIMKR-- 718
++A R Q+ +E + R +EE +RQ L ER+K +QQ +E+R+RLEE +R
Sbjct: 367 SEAL-----RRQQLLQEQQLREQEEYKRQLLAERQKRIEQQ----KEQRRRLEEQQRRER 417
Query: 719 -TRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
R+ + E ++++ ++ + E R +K V++E+
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQ 465
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/90 (27%), Positives = 52/90 (57%), Gaps = 3/90 (3%)
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE---EQRLKAEQRRAALEER 199
+E+ E + + LA ++ +++E+ + L E+Q +ER R + EQR + ++ + LEE
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEEL 441
Query: 200 QRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+R++ E+ + R +R V++ IR+Q
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQ 471
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/78 (30%), Positives = 45/78 (57%), Gaps = 11/78 (14%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAK--ALREKQLQERRRRLEEQRLKAEQRRA 194
ER K ++++E+R + LE++++ + A R+++ ++RRR EE+R E R
Sbjct: 394 ERQKRIEQQKEQRRR---------LEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 195 ALEERQRQKLEKNKERYE 212
EE +R++ E+ K R E
Sbjct: 445 RKEEEERRRAEEEKRRVE 462
Score = 41.2 bits (95), Expect = 0.004
Identities = 105/583 (18%), Positives = 209/583 (35%), Gaps = 81/583 (13%)
Query: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQR-LKA 189
E +K R ++RRE A+ ++ E+EEK R ++L+ RR+ EE+R +
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKR---RLEELERRRKEEEERRRAEE 456
Query: 190 EQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGS 249
E+RR E+ ++ + ++R+ +Q+ + + A + + RW H + +
Sbjct: 457 EKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEE-HRQAERLQRQLQ 515
Query: 250 RCSVSAVNL--------PKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLM 301
+ ++L P+H + +S + +++P + + + DR
Sbjct: 516 QEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPS-FHAPEPKAHYEPADRAREVEDRF- 573
Query: 302 TPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVC 361
R + + + GR +P P R+ S + G + HP+ P
Sbjct: 574 --------RKTNHSSPEAQSKQTGRVLEP---PVPSRS-ESFSNG-NSESVHPALQRPAE 620
Query: 362 PR------SASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKK 415
P+ ++ + ++P S + S +P R + P P P S V +
Sbjct: 621 PQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD----PCP----PSRSEVLSQ 672
Query: 416 EKKDKERENEKEKSALARERSLKKRQSLPASPRARL------------SASTASELSPKS 463
K + + A +R S + +P +R S S+ ++
Sbjct: 673 SSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRN 732
Query: 464 KARPSSPSTSWHRPASPCPSPGPGHT-----LPPKPPSPRGTT--ASPKGRVRRKEEAKE 516
P W R P PG G + +P S G+ + + RVR +++
Sbjct: 733 STSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEG 792
Query: 517 SPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTS 576
SPS + + ++ ++KE P PA + + A
Sbjct: 793 SPS----QRLENAVKKPEDKKEVFRPLKPA-----------GEVDLTALAKELRAVEDVR 837
Query: 577 PPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQL 636
PP + S +GTTD E+ + ++ ++ ++ R + + E +
Sbjct: 838 PPHKVTDYSSSSEESGTTDEED-----DDVEQEGADESTSGPEDTRAASSLNLSNGETES 892
Query: 637 AREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEA 679
+ + E+E +E + Q LQK K +
Sbjct: 893 VKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 935
Score = 40.0 bits (92), Expect = 0.009
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 109 PRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE-RAKYLAAKKAVWLEKEEKA 167
P + +PS +S + ++ E KER E R + L ++ + ++E K
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQEN----KERSEALRRQQLLQEQQLREQEEYKR 389
Query: 168 KALREKQLQ-----ERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQR 217
+ L E+Q + E+RRRLEEQ+ + + R E QR++ ++ K R E +R
Sbjct: 390 QLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Score = 33.5 bits (75), Expect = 0.85
Identities = 103/548 (18%), Positives = 180/548 (32%), Gaps = 77/548 (14%)
Query: 107 RPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEK 166
R RR Q + + ++E ++ E K ER +E Y+ + LE+E++
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQE---YIRRQ----LEEEQR 477
Query: 167 AKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEI 226
+ ++QL + + L E R + + E QRQ + ++ Y ++Q ++ +
Sbjct: 478 HLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQL--QQEQAYLLSLQHDHRRPHPQH 535
Query: 227 RQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINK-------RLSKSSATLWN 279
QQ S P + + + V+ K SK + +
Sbjct: 536 SQQ--PPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLE 593
Query: 280 SPSRNRSLQLSAWES-SIVDRLMTPT--------LSFLARSRSAVTLPRNGRDQG----- 325
P +RS S S S+ L P L+ L + S V+ + D
Sbjct: 594 PPVPSRSESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAH 653
Query: 326 ------RGCDPGRGPTWGRAGASLARGPQP-----DRTHPSAAVPVCP-RSASASPL--- 370
C P R ++ S + P P R+ P P R+ S SP+
Sbjct: 654 HHLRSQDPCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSR 713
Query: 371 TPCSVTRSVHRCAPAGERGERRKPNAGGSPAP----------VRRRPEASPVQKKEKKDK 420
+ S + + AG+R N+ S P V R S +
Sbjct: 714 RDSPLQGSGQQNSQAGQR------NSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQ 767
Query: 421 ERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASP 480
+ +S ++ SP RL + K RP P+ A
Sbjct: 768 PGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALA 827
Query: 481 CPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKE----SPSAAGPED--KSQSKRRAS 534
PP + +++ G +++ E S +GPED + S ++
Sbjct: 828 KELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSN 887
Query: 535 NEKESA--------APASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTP 586
E ES + PA +P+ T Q + + + + P P +
Sbjct: 888 GETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQ 947
Query: 587 SKPMAGTT 594
P +GTT
Sbjct: 948 ISPSSGTT 955
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 82.8 bits (203), Expect = 1e-15
Identities = 41/115 (35%), Positives = 76/115 (66%), Gaps = 1/115 (0%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREE-QLAREAEARAEREAEARRR 653
++E + L ++ Q ++ RE+EE +R+L AER KR+ ++ + R E + RE EARR+
Sbjct: 363 NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQ 422
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQER 708
+E+E R + Q E+ E L+++++E E R R E E++R+ERE+ + +++ E ++R
Sbjct: 423 QEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Score = 73.2 bits (178), Expect = 1e-12
Identities = 57/174 (32%), Positives = 93/174 (53%), Gaps = 17/174 (9%)
Query: 608 RQAREQREREEQERRLQAERDKRMREE-----QLAREAEARAEREAEARRR-EEQEARE- 660
R +E +ER E RR Q +++++RE+ QL E + R E++ E RRR EEQ+ RE
Sbjct: 358 RLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRER 417
Query: 661 --KAQAEQEEQERLQKQK---EEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEI 715
+ Q E+E++ R Q++K EE E R +EE ER+R E EK ++ E+E++ R++LEE
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEK--RRVEREQEYIRRQLEE- 474
Query: 716 MKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQ 769
R EV + + Q+ + P P + + P ++ P P+
Sbjct: 475 --EQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPK 526
Score = 60.5 bits (145), Expect = 6e-09
Identities = 54/195 (27%), Positives = 89/195 (45%), Gaps = 28/195 (14%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMRE-EQLAREAEARAEREAEARR-- 652
+E+ RL ++RR+ +R++E ++RR + E +R+ E E+ +E E R E E RR
Sbjct: 403 KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 653 REEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK-- 710
RE++ R + + EQ E LQ+Q + +A + R +H QQ +QER K
Sbjct: 463 REQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHD---HRRPHPQHSQQPPPPQQERSKPS 519
Query: 711 --------------RLEEI-MKRTRKSEVSETKQK--QDSKEANANGSSPEPVKAVEARS 753
R E+ ++ T +S V + Q S + N+ ++E
Sbjct: 520 FHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIE--- 576
Query: 754 PGLQKEAVQKEEPIP 768
P L E V+K P P
Sbjct: 577 PRLLWERVEKLVPRP 591
Score = 57.0 bits (136), Expect = 7e-08
Identities = 52/189 (27%), Positives = 88/189 (46%), Gaps = 25/189 (13%)
Query: 612 EQREREEQERR----LQAERDKRMREEQLAREAEARAEREAEARRR--EEQEARE----K 661
E+ E EQE + + +R + L + E + EA R++ +EQ+ RE K
Sbjct: 329 EEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYK 388
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQER---QERRKRLEEIMKR 718
Q E Q+R+++QKE+ R E+QR ERE QQ+ ++R QE ++RLEE+ +R
Sbjct: 389 RQLLAERQKRIEQQKEQR----RRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 719 TRKSE----VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAV----QKEEPIPQE 770
++ E E K++ + ++ E + +E L +E P PQ
Sbjct: 445 RKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQH 504
Query: 771 PQWSLPSKE 779
Q P ++
Sbjct: 505 SQQPPPPQQ 513
Score = 51.6 bits (122), Expect = 3e-06
Identities = 42/168 (25%), Positives = 84/168 (50%), Gaps = 16/168 (9%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR---REEQEAREK 661
++ R+ R +++ E E E ++ + E++ + E+ RR R +QE +E+
Sbjct: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER 366
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRL-EREKHFQQQEQERQERRKRLEEIMKR-- 718
++A R Q+ +E + R +EE +RQ L ER+K +QQ +E+R+RLEE +R
Sbjct: 367 SEAL-----RRQQLLQEQQLREQEEYKRQLLAERQKRIEQQ----KEQRRRLEEQQRRER 417
Query: 719 -TRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
R+ + E ++++ ++ + E R +K V++E+
Sbjct: 418 EARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQ 465
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/90 (27%), Positives = 52/90 (57%), Gaps = 3/90 (3%)
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE---EQRLKAEQRRAALEER 199
+E+ E + + LA ++ +++E+ + L E+Q +ER R + EQR + ++ + LEE
Sbjct: 382 REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEEL 441
Query: 200 QRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+R++ E+ + R +R V++ IR+Q
Sbjct: 442 ERRRKEEEERRRAEEEKRRVEREQEYIRRQ 471
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/78 (30%), Positives = 45/78 (57%), Gaps = 11/78 (14%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAK--ALREKQLQERRRRLEEQRLKAEQRRA 194
ER K ++++E+R + LE++++ + A R+++ ++RRR EE+R E R
Sbjct: 394 ERQKRIEQQKEQRRR---------LEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Query: 195 ALEERQRQKLEKNKERYE 212
EE +R++ E+ K R E
Sbjct: 445 RKEEEERRRAEEEKRRVE 462
Score = 40.0 bits (92), Expect = 0.009
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 109 PRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE-RAKYLAAKKAVWLEKEEKA 167
P + +PS +S + ++ E KER E R + L ++ + ++E K
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQEN----KERSEALRRQQLLQEQQLREQEEYKR 389
Query: 168 KALREKQLQ-----ERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQR 217
+ L E+Q + E+RRRLEEQ+ + + R E QR++ ++ K R E +R
Sbjct: 390 QLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERR 444
Score = 35.0 bits (79), Expect = 0.29
Identities = 34/151 (22%), Positives = 58/151 (38%), Gaps = 12/151 (7%)
Query: 26 RPSPEGDPSPPPPPMSALVPDTPPDTPPA-MKNATSSKQLPLEPESPSGQVGPRPAPPQE 84
RP P+ PPPP P P A + A ++++P+ S S + R +P Q
Sbjct: 499 RPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSPLQG 558
Query: 85 ESPSSEAKSRGPTPPAMGPR---------DARPPRRSSQPSPTAVPASDSPPTKQEVKKA 135
+ + + ++ PR RP SS S + S P Q +
Sbjct: 559 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQ--SGS 616
Query: 136 GERHKLAKERREERAKYLAAKKAVWLEKEEK 166
GER ++ + E + + AV +++K
Sbjct: 617 GERFRVRSSSKSEGSPSQRLENAVKKPEDKK 647
Score = 33.9 bits (76), Expect = 0.65
Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 4/78 (5%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E ++ ER + +E+ E+R ++ E+EE+ +A EK+ ER + ++L+
Sbjct: 416 EREARRQQEREQRRREQEEKRRLEELERRRK--EEEERRRAEEEKRRVEREQEYIRRQLE 473
Query: 189 AEQRRAALEERQRQKLEK 206
EQR LE Q+Q L++
Sbjct: 474 EEQRH--LEVLQQQLLQE 489
Score = 33.1 bits (74), Expect = 1.1
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 11/96 (11%)
Query: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQE-RRRRLE-EQRLK 188
E +K R ++RRE A+ ++ E+EEK ++L+E RRR E E+R +
Sbjct: 400 EQQKEQRRRLEEQQRREREARRQQEREQRRREQEEK------RRLEELERRRKEEEERRR 453
Query: 189 AEQRRAALEERQ---RQKLEKNKERYEAAIQRSVKK 221
AE+ + +E Q R++LE+ + E Q+ +++
Sbjct: 454 AEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQE 489
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 82.0 bits (201), Expect = 2e-15
Identities = 56/184 (30%), Positives = 97/184 (52%), Gaps = 15/184 (8%)
Query: 598 EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQE 657
E + L E+ ++ REQ+E EQE ++Q + +K +E+ RE E + R+ E +E++
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
Query: 658 AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMK 717
RE+ Q ++++ER+ +Q E R RE+ ER R E+EK ++Q E+ R+E K+++E K
Sbjct: 385 MREQEQKMRDQEERMWEQDE----RLREKEERMR-EQEKMWEQVEKMREE--KKMQEQEK 437
Query: 718 RTRKSE--------VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQ 769
+TR E + E ++K +E + K E +KE Q+ P +
Sbjct: 438 KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 497
Query: 770 EPQW 773
E W
Sbjct: 498 EKLW 501
Score = 74.3 bits (181), Expect = 4e-13
Identities = 55/194 (28%), Positives = 106/194 (54%), Gaps = 13/194 (6%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQ-LAREAEARAEREAEARRR 653
+R E EK+ +E++ REE+ R ER+K+MREE+ + RE E + + + E +
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMR---EREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREK-----HFQQQEQER-QE 707
+E++ E+ + QE++E++ +Q+E+ + + E+QRL +K H + QEQE+ QE
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 708 RRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGL--QKEAVQKEE 765
+ +++ E K +K++ E K+ D ++ S E K + + Q+E +Q++E
Sbjct: 682 QEEKIWEQEKMEKKTQEQE-KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
Query: 766 PIPQEPQWSLPSKE 779
QE + + +E
Sbjct: 741 EKMQEQEEEMWEQE 754
Score = 73.6 bits (179), Expect = 7e-13
Identities = 59/186 (31%), Positives = 102/186 (54%), Gaps = 14/186 (7%)
Query: 594 TDREEATRLLAEKRRQAREQREREE----QERRLQAERDK-RMREEQLAREAEARAEREA 648
T +EE R E R Q ++ R++EE QE RL+ + K R +EE++ R+ + E+E
Sbjct: 269 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEK 328
Query: 649 EARRREEQEAREKAQAEQEEQERLQKQKE-EAEARSREEAER-----QRL-EREKHFQQQ 701
E R +E++ +K EQEEQ + Q++K E E + RE+ E+ +RL E+EK ++Q
Sbjct: 329 ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 388
Query: 702 EQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAV 761
EQ+ +++ +R+ E +R R+ E E ++Q+ E + + Q+E +
Sbjct: 389 EQKMRDQEERMWEQDERLREKE--ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 762 QKEEPI 767
Q+EE I
Sbjct: 447 QEEERI 452
Score = 72.4 bits (176), Expect = 2e-12
Identities = 48/193 (24%), Positives = 100/193 (51%), Gaps = 8/193 (4%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQA-ERDKRMREEQLAREAEARAEREAEARRR 653
++EE R +K E+ E++ QE+ + +++++MREE+ RE E + E E R
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607
Query: 654 EEQEAREKAQAEQEEQERLQKQKE---EAEARSREEAERQRLEREKHFQQQEQERQERRK 710
+E++ +E+ + QE++E++ +Q+E E E + E+ E+ + EK ++QQ Q+ +
Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Query: 711 RLEEIMKRTRKSEVSETK----QKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEP 766
E M+ K + E K +K + K + + K E S +++ +++EE
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
Query: 767 IPQEPQWSLPSKE 779
+ +E + + +E
Sbjct: 728 MMREQEEKMQEQE 740
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/207 (24%), Positives = 99/207 (47%), Gaps = 24/207 (11%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
RE+ ++ ++ + R++ EQE +++ + +K R+E+ RE E RE E RE+
Sbjct: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL-REQEKELREQ 340
Query: 656 QEAREKAQA---------EQEEQERLQKQKE--------EAEARSREEAERQRLEREKHF 698
+E RE+ + EQEE+ R Q++K E E + RE+ ++ R + E+ +
Sbjct: 341 KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 400
Query: 699 QQQE--QERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGL 756
+Q E +E++ER + E++ ++ K + Q+Q+ K + E + E
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
Query: 757 QKEAVQKEEPIPQEPQ----WSLPSKE 779
++E +E+ + Q W KE
Sbjct: 461 EEEETMREQEEKMQKQEENMWEQEEKE 487
Score = 68.9 bits (167), Expect = 2e-11
Identities = 49/190 (25%), Positives = 101/190 (53%), Gaps = 16/190 (8%)
Query: 598 EATRLLAEKRRQAREQR--EREEQERRLQAERDK-----RMREEQLAREAEARAEREAEA 650
E ++ +++ Q +E++ E+E+ E++ Q + K +MREE+ RE E + E E
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREK-----HFQQQEQER 705
R +E++ +E+ + QE++E + +Q+E+ + + E+QRL +K H + QEQE+
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 706 ---QERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQ 762
QE + R +E R ++ ++ ++K +E G E + E + G +++
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE-EKMWGQEEKMWGQEEKMWG 847
Query: 763 KEEPIPQEPQ 772
+EE + ++ Q
Sbjct: 848 QEEKMEEKMQ 857
Score = 68.6 bits (166), Expect = 2e-11
Identities = 50/186 (26%), Positives = 96/186 (51%), Gaps = 8/186 (4%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMRE-EQLAREAEARAEREAEARRREE 655
+E + E+ + REQ E+ ++ E++K+MRE EQ R+ E R + E R +E
Sbjct: 351 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 410
Query: 656 QEAREKAQA-EQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
+ RE+ + EQ E+ R +K+ +E E ++R++ E +++ E+ +++E++ +E + + E
Sbjct: 411 ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEE--KMQEEERIREREKKMREEEETMRE 468
Query: 715 IMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAV--QKEEPIPQEPQ 772
++ +K E E +Q+ KE + K E Q+E + Q+E+ QE
Sbjct: 469 QEEKMQKQE--ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 526
Query: 773 WSLPSK 778
W K
Sbjct: 527 WGQEKK 532
Score = 67.4 bits (163), Expect = 5e-11
Identities = 33/135 (24%), Positives = 74/135 (54%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
RE+ ++ ++ R ++++ EQE++++ + ++ +++ RE E R + + + E
Sbjct: 365 REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424
Query: 656 QEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEI 715
+ EK EQE++ R Q++K + E R RE ++ R E E +Q+E+ +++ E+
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE 484
Query: 716 MKRTRKSEVSETKQK 730
K ++ + E K+K
Sbjct: 485 EKEWQQQRLPEQKEK 499
Score = 67.0 bits (162), Expect = 7e-11
Identities = 43/142 (30%), Positives = 81/142 (57%), Gaps = 5/142 (3%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMRE-EQLAREAEARAEREAEARRRE 654
R+E EK+ + +EQ+ R+++ER E+D+R+RE E+ RE E E+ + R +
Sbjct: 373 RQEERLWEQEKQMREQEQKMRDQEER--MWEQDERLREKEERMREQEKMWEQVEKMREEK 430
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ--ERQERRKRL 712
+ + +EK +QEE+ + +++ E E + REE E R + EK +Q+E E++E+ +
Sbjct: 431 KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 490
Query: 713 EEIMKRTRKSEVSETKQKQDSK 734
+ + ++ K E Q+Q+ K
Sbjct: 491 QRLPEQKEKLWEQEKMQEQEEK 512
Score = 66.2 bits (160), Expect = 1e-10
Identities = 55/203 (27%), Positives = 93/203 (45%), Gaps = 24/203 (11%)
Query: 593 TTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
T D+EE R E+R + RE++ REE+E + E + +EE++ + E E+E + +
Sbjct: 578 TWDQEEKMR--EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Query: 653 REEQ--EAREKAQAEQE---EQERLQKQKE-----------------EAEARSREEAERQ 690
+EE+ E EK ++E EQ+RL +QKE E + +E+ E++
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 691 RLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVE 750
E+EK QE+ R+E R E R + + E ++K +E E + E
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 751 ARSPGLQKEAVQKEEPIPQEPQW 773
+K Q+ P +E W
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLW 778
Score = 65.1 bits (157), Expect = 3e-10
Identities = 57/207 (27%), Positives = 106/207 (51%), Gaps = 26/207 (12%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQ-LAREAEARAEREAEAR-RR 653
REE + + E+ ++ R+Q E+ ++E R++ ER+K+MREE+ RE E + +++ E +
Sbjct: 427 REE--KKMQEQEKKTRDQEEKMQEEERIR-EREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 654 EEQEAREKAQAEQEE----QERLQKQKE---EAEARSREEAE---------RQRLEREKH 697
EE+E +++ EQ+E QE++Q+Q+E E E + R++ E RQ RE+
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 698 FQQQEQERQERRKR-----LEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEAR 752
Q EQE + R + EE M++ + + +T +++ E E
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 753 SPGLQKEAVQKEEPIPQEPQWSLPSKE 779
Q+E +Q++E QE + + +E
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQE 630
Score = 64.7 bits (156), Expect = 3e-10
Identities = 47/189 (24%), Positives = 98/189 (51%), Gaps = 6/189 (3%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
REE EK+ + E+ R EQE ++Q + +K +E+ E E + + E E + E+
Sbjct: 586 REEERMREREKKMREEEEMMR-EQEEKMQEQEEKMQEQEEKMWEQEEKMQ-EQEEKMWEQ 643
Query: 656 QEAREKAQAEQEEQERLQKQKEEA-EARSREEAERQRLEREKHFQQQEQER--QERRKRL 712
+E + + + EQ+RL +QKE+ E +E E+ + + EK ++Q++ E+ QE+ K+
Sbjct: 644 EEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT 703
Query: 713 EEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
+ ++ R+ E ++K+ +E E ++ E + ++E ++EE + ++ +
Sbjct: 704 WD-QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE 762
Query: 773 WSLPSKELP 781
+ LP
Sbjct: 763 KMWEQQRLP 771
Score = 63.9 bits (154), Expect = 6e-10
Identities = 46/190 (24%), Positives = 98/190 (51%), Gaps = 8/190 (4%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
E+ ++ EK+ Q +E++ R+ QE ++Q E R RE+++ E E E+E + +++EE
Sbjct: 421 EQVEKMREEKKMQEQEKKTRD-QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 657 --EAREKAQAEQ---EEQERL--QKQKEEAEARSREEAERQRLEREKHFQQQEQERQERR 709
E EK +Q E++E+L Q++ +E E + E+ E+ R + E Q+++ RQE+
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539
Query: 710 KRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQ 769
+ E+ M + + ++ D +E + + K + ++E +++ E +
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
Query: 770 EPQWSLPSKE 779
E + + +E
Sbjct: 600 EEEEMMREQE 609
Score = 63.5 bits (153), Expect = 8e-10
Identities = 45/183 (24%), Positives = 99/183 (54%), Gaps = 12/183 (6%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ--EAREKA 662
E+ + RE+++ +EQE++ + +++++M+EE+ RE E + E E R +E+ + +E+
Sbjct: 421 EQVEKMREEKKMQEQEKKTR-DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 663 QAEQEEQE----RLQKQKEEA-EARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMK 717
EQEE+E RL +QKE+ E +E E + E+E+ + QE+ + +K +
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539
Query: 718 RTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPS 777
R ++ ++ E ++K +E + + +E ++ +K+ +EE + +E +
Sbjct: 540 REQEDQMWEQEEKMRDQEQ----KMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE 595
Query: 778 KEL 780
K++
Sbjct: 596 KKM 598
Score = 63.5 bits (153), Expect = 8e-10
Identities = 50/202 (24%), Positives = 94/202 (46%), Gaps = 16/202 (7%)
Query: 595 DREEATRLLAEKRRQARE----QREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
+ EE R EK ++ E Q E+E Q++RL +++K +E++ + E E+E +
Sbjct: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
Query: 651 RRREEQEAREKAQAEQE----------EQERLQKQKEEAEARSREEAERQRLEREKH-FQ 699
R +EE +EK QE EQE + +E+ E E++ E+EK +
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 700 QQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKE 759
Q+E+ R+E R R E R + + E ++K +E E + E + +++
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ-EQEEKMWEQEEKMQEQEEK 639
Query: 760 AVQKEEPIPQEPQWSLPSKELP 781
++EE + ++ + + LP
Sbjct: 640 MWEQEEKMWEQEEKMWEQQRLP 661
Score = 63.5 bits (153), Expect = 8e-10
Identities = 40/180 (22%), Positives = 90/180 (50%), Gaps = 6/180 (3%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
+E + E+ + R+Q E QE+++ + R +E+Q+ + E ++E + +EE+
Sbjct: 507 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 657 EAREKAQAEQEEQERLQKQKEEAEARSRE----EAERQRLEREKHFQQQEQERQERRKRL 712
++ + E++ ++ +K +EE R RE E E E+E+ Q+QE++ QE+ +++
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626
Query: 713 EEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
E + + E E +Q+ K E + E + + E +Q++E + ++ +
Sbjct: 627 WE--QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEE 684
Score = 57.8 bits (138), Expect = 4e-08
Identities = 35/182 (19%), Positives = 90/182 (49%), Gaps = 5/182 (2%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE 655
+E+ ++ ++ + ++ + +EQE ++ + +K +E+ E + E++ + E+
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK 672
Query: 656 QEAREKAQAEQE---EQERLQKQKEEAEARS--REEAERQRLEREKHFQQQEQERQERRK 710
+ +EK Q ++E EQE+++K+ +E E ++ +E+ + RE+ + +E+E R +
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ 732
Query: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
+ + + E E +Q+ K E + E + + E +Q++E I ++
Sbjct: 733 EEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Query: 771 PQ 772
+
Sbjct: 793 EE 794
Score = 57.0 bits (136), Expect = 7e-08
Identities = 40/170 (23%), Positives = 81/170 (47%), Gaps = 22/170 (12%)
Query: 611 REQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
R++ E EQE++++ + +K R+E+ RE E + + E R+E+ RE+ + +E+++
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335
Query: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQK 730
L++QKE ++QE++ QE+ +++ E ++ R+ E +Q+
Sbjct: 336 ELREQKE--------------------LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 375
Query: 731 QDSKEANANGSSPE-PVKAVEARSPGLQKEAVQKEEPI-PQEPQWSLPSK 778
+ E E ++ E R + +KEE + QE W K
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Score = 57.0 bits (136), Expect = 7e-08
Identities = 46/187 (24%), Positives = 96/187 (51%), Gaps = 14/187 (7%)
Query: 593 TTDREEAT----RLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREA 648
T ++E+ T ++ E+ + RE++ REE+E + E + +EE++ + E E+E
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 649 EARRREEQEAREKAQAEQEEQ----ERLQKQKE--EAEARSREEAERQRLEREKHFQQQE 702
+ +EE+ ++ EQ+E+ E++Q+Q++ E E + R++ E+ R + EK Q+E
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Query: 703 QERQERRK---RLEEIMKRTRKSEVSETKQ-KQDSKEANANGSSPEPVKAVEARSPGLQK 758
+ R + K + E++ + K E K Q+ K E ++ E + G ++
Sbjct: 816 KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE 875
Query: 759 EAVQKEE 765
+ ++EE
Sbjct: 876 KMREQEE 882
Score = 56.6 bits (135), Expect = 9e-08
Identities = 42/192 (21%), Positives = 96/192 (50%), Gaps = 23/192 (11%)
Query: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR-REEQEAREK 661
L E++ + E + +EQE+ +Q + +K +E++ ++ + + ++ + + REE+ RE+
Sbjct: 660 LPEQKEKLWEHEKMQEQEK-MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
Query: 662 AQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQE-------------QERQER 708
+ +EE+E +++Q+E+ + E E + E+E+ +QE Q E+
Sbjct: 719 EKKMREEEEMMREQEEKMQ-----EQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQ 773
Query: 709 RKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPI- 767
+++L E K + ++ E ++K +E G E ++ E + G +++ +EE +
Sbjct: 774 KEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQE-EKMRGQEEKMRGQEEKMWGQEEKMW 832
Query: 768 -PQEPQWSLPSK 778
+E W K
Sbjct: 833 GQEEKMWGQEEK 844
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/187 (20%), Positives = 96/187 (51%), Gaps = 12/187 (6%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
D+EE + ++++ R+++ RE++++ + E +K +EQ + E R E++ + + ++
Sbjct: 522 DQEE---MWGQEKKMWRQEKMREQEDQMWEQE-EKMRDQEQKMWDQEERMEKKTQEQEKK 577
Query: 655 EQEAREKAQAEQE--EQERLQKQKE----EAEARSREEAERQRLEREKHFQQQE--QERQ 706
+ EK + E+ E+E+ +++E E E + +E+ E+ + + EK ++Q+E QE++
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637
Query: 707 ERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEP 766
E+ EE M + + + + ++ + E K E ++E ++K+
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697
Query: 767 IPQEPQW 773
++ W
Sbjct: 698 EQEKKTW 704
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/138 (28%), Positives = 73/138 (52%), Gaps = 10/138 (7%)
Query: 603 LAEKRRQAREQ---REREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAR 659
L +K + +E+ E E+ E +L + KR E + + E R+E+E R
Sbjct: 223 LKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELR 282
Query: 660 EKAQAEQEEQERLQKQKE---EAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIM 716
E+ + ++++E++ +Q+E E E + RE+ E+ +EK ++QE+E +E+ K L E
Sbjct: 283 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-WRQEKRLREQEKELREQEKELRE-Q 340
Query: 717 KRTRKSEVSETKQKQDSK 734
K R+ E E Q+Q+ K
Sbjct: 341 KELREQE--EQMQEQEEK 356
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/121 (28%), Positives = 64/121 (52%), Gaps = 13/121 (10%)
Query: 603 LAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREE----QEA 658
L E++ + E + +EQE+ + E R +EE++ + E +E + R +EE QE
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
Query: 659 REKAQAE----QEE-----QERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERR 709
+ Q E QEE +E+++++ + E + RE+ E+ R + EK +Q+E+ R +
Sbjct: 830 KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Query: 710 K 710
K
Sbjct: 890 K 890
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/118 (23%), Positives = 65/118 (55%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
E+ +L ++ Q +E+ +E++ R Q E+ + E+ +E + R + E + E+
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831
Query: 657 EAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
+E+ QEE+ Q++K E + + +EE R++ E+ + +++ +E++E+ + EE
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 44.7 bits (104), Expect = 4e-04
Identities = 33/141 (23%), Positives = 69/141 (48%), Gaps = 3/141 (2%)
Query: 605 EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ-EAREKAQ 663
E+ + EQ+ EQ+ +L E +K +E++ + E ++E + R +EE+ +E+
Sbjct: 759 EQEEKMWEQQRLPEQKEKLW-EHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM 817
Query: 664 AEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMK-RTRKS 722
QEE+ Q++K + E + +E+ +++ Q ++E+ + EE M+ + K
Sbjct: 818 RGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKM 877
Query: 723 EVSETKQKQDSKEANANGSSP 743
E K + ++ GS P
Sbjct: 878 REQEEKMRGQEEKIYCVGSPP 898
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/127 (26%), Positives = 65/127 (51%), Gaps = 5/127 (3%)
Query: 612 EQREREEQERRLQAERDKRMREEQL-AREAEARAEREAEARRREEQEAREKAQAEQEEQE 670
+++ E QE+ AE +K E QL +E + + ER + + ++ QEE+
Sbjct: 224 KKKNAELQEKLPLAESEKS--EIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 281
Query: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQE--RQERRKRLEEIMKRTRKSEVSETK 728
R Q++K + E + E+E ++QE++ RQE+R R +E R ++ E+ E K
Sbjct: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK 341
Query: 729 QKQDSKE 735
+ ++ +E
Sbjct: 342 ELREQEE 348
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/103 (20%), Positives = 56/103 (54%), Gaps = 4/103 (3%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+++ +K E+ K+ K+ +E+ K +K +EE++ REK+++E + EQ K
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKM----REEESMREREKKMREEEEMMREQEEK 735
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
+++ ++E++ + E+ ++ +E + ++ E +++ W
Sbjct: 736 MQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/103 (22%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+QE K + K+ + K +K W ++EEK + + +E++ R EE+ ++
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW-DQEEKMREEERMREREKKMREEEEMMR 606
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
++ + +E + Q+ E+ E +Q +K W E ++ W
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW-EQEEKMW 648
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/103 (24%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 129 KQEVKKAGERHKLAKERR-EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+QE K + K+ +E R ER K + ++ + E+EEK + +E+++QE+ ++ EQ
Sbjct: 573 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE-QEEKMQEQEEKMWEQEE 631
Query: 188 KAEQRRAALEERQRQKLEKNKERYE-AAIQRSVKKTWAEIRQQ 229
K +++ + E++ + E+ ++ +E + +K W + Q
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 674
Score = 40.4 bits (93), Expect = 0.007
Identities = 29/106 (27%), Positives = 54/106 (50%), Gaps = 12/106 (11%)
Query: 129 KQEVKKAGERHKLAKER-REERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+++++K E+ +ER RE+ K ++ +W ++EK +EK+L+E+ + L EQ+
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMW--RQEKRLREQEKELREQEKELREQKE 342
Query: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSW 233
EQ E Q Q+ E+ E ++ +K W RQ+ W
Sbjct: 343 LREQ------EEQMQEQEEKMWEQEEKMREQEEKMW---RQEERLW 379
Score = 40.4 bits (93), Expect = 0.007
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 3/104 (2%)
Query: 128 TKQEVKKAGERHKLAKERR-EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQR 186
T+++ KK ++ K+ +E ER K + ++ + E+EEK + EK +QE+ + EQ
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK-MQEQEEEMWEQE 754
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
K ++ + E+QR +K K +E + +K W + + R
Sbjct: 755 EKMWEQEEKMWEQQRLPEQKEK-LWEHEKMQEQEKIWEQEEKMR 797
Score = 40.0 bits (92), Expect = 0.009
Identities = 24/98 (24%), Positives = 50/98 (51%), Gaps = 3/98 (3%)
Query: 129 KQEVKKAGERHKLAKERR-EERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
+QE K + K+ +E R ER K + ++ E+EEK + E ++ + ++QRL
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAE 225
++ + +E+ +++ EK E+ E R ++ W +
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKI--RDQEEMWGQ 529
Score = 39.3 bits (90), Expect = 0.015
Identities = 27/104 (25%), Positives = 57/104 (54%), Gaps = 5/104 (4%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLE-EQRL 187
++E+++ + + KE RE+ + ++ +W E+EEK + EK ++ R E E+++
Sbjct: 327 EKELREQEKELREQKELREQEEQMQEQEEKMW-EQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 188 K-AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ EQ+ EER ++ E+ +E+ E R +K W ++ + R
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEER--MREQEKMWEQVEKMR 427
Score = 38.9 bits (89), Expect = 0.020
Identities = 22/104 (21%), Positives = 55/104 (52%), Gaps = 5/104 (4%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLE----KEEKAKALREKQLQERRRRL-E 183
+Q+++ ER ER E+ + + ++ +W + +EEK +EK+ +++ ++ E
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE 448
Query: 184 EQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIR 227
E+R++ +++ EE ++ E+ ++ E + +K W + R
Sbjct: 449 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Score = 38.9 bits (89), Expect = 0.020
Identities = 24/106 (22%), Positives = 54/106 (50%), Gaps = 7/106 (6%)
Query: 129 KQEVKKAGERHKLAKER----REERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
++ KK E ++ +E+ +E+ K ++ +W E+EEK + EK ++ + E+
Sbjct: 592 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW-EQEEKMQEQEEKMWEQEEKMWEQ 650
Query: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+ EQ+R L E++ + E K + + +Q +K W + + ++
Sbjct: 651 EEKMWEQQR--LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694
Score = 38.9 bits (89), Expect = 0.020
Identities = 26/104 (25%), Positives = 51/104 (49%), Gaps = 10/104 (9%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++ +++ E+ + +E+ +E+ + + ++ E+EEK EK ++ + E+QRL
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 189 AEQRRAALEERQRQKLEK---------NKERYEAAIQRSVKKTW 223
EQ+ E + Q+ EK +E+ E Q KKTW
Sbjct: 662 -EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Score = 38.1 bits (87), Expect = 0.034
Identities = 22/104 (21%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
T+++ KK ++ + K R EER + K + +EE+ +E+++QE+ +++EQ
Sbjct: 571 TQEQEKKTWDQEE--KMREEERMREREKK----MREEEEMMREQEEKMQEQEEKMQEQEE 624
Query: 188 KAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
K ++ ++E++ + E+ ++ +E + ++ E +++ W
Sbjct: 625 KMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Score = 36.6 bits (83), Expect = 0.100
Identities = 23/94 (24%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+QE K + K+ RE+ K ++ +W ++++ + ++ + QE R +++RL+
Sbjct: 352 EQEEKMWEQEEKM----REQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKT 222
++ R +E+ +++EK +E E +Q KKT
Sbjct: 408 EKEERMREQEKMWEQVEKMRE--EKKMQEQEKKT 439
Score = 36.2 bits (82), Expect = 0.13
Identities = 21/94 (22%), Positives = 45/94 (47%), Gaps = 1/94 (1%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
E + +E RE+ K ++ +W ++E + + + QE + +E+RL+ EQ +
Sbjct: 273 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR-EQEKELR 331
Query: 197 EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
E+ + + +K E +Q +K W + + R
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMR 365
Score = 35.4 bits (80), Expect = 0.22
Identities = 22/94 (23%), Positives = 49/94 (52%), Gaps = 11/94 (11%)
Query: 144 ERREERAKYL-------AAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
+R+ ERAK+L ++ +W ++EE + ++ + QE + +E+RL+ ++ +
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311
Query: 197 EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+E + + EK E ++ K E+R+Q+
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEK----ELREQK 341
Score = 35.4 bits (80), Expect = 0.22
Identities = 23/109 (21%), Positives = 55/109 (50%), Gaps = 7/109 (6%)
Query: 130 QEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKA 189
++V+K E K+ ++ ++ R + ++ + + EK E+ ++E+ ++++Q
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 480
Query: 190 EQRRAALEERQRQKLEKNKERY--EAAIQRSVKKTWAE---IRQQRWSW 233
++ +E Q+Q+L + KE+ + +Q +K W + IR Q W
Sbjct: 481 WEQEE--KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Score = 34.7 bits (78), Expect = 0.38
Identities = 20/96 (20%), Positives = 45/96 (46%), Gaps = 9/96 (9%)
Query: 144 ERREERAKYLAAKKAVW--------LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAA 195
E+ +E+ K ++ +W +++EK +EK +E R E++++ E+
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 196 LEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
+E + Q+ E+ + E + +K W E ++ W
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMW-EQEEKMW 765
Score = 33.9 bits (76), Expect = 0.65
Identities = 24/90 (26%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 129 KQEVKKAGERHKL--AKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQR 186
+QE K + K+ +ER E+ K + ++ ++EE+ ++++L+E+ R+ EQ
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE-QDERLREKEERMREQE 417
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQ 216
EQ EE++ Q+ EK E +Q
Sbjct: 418 KMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Score = 33.5 bits (75), Expect = 0.85
Identities = 34/158 (21%), Positives = 60/158 (37%), Gaps = 10/158 (6%)
Query: 83 QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA 142
+++ E K+R R + + + + KQE + K
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 488
Query: 143 KERREERAKYLAAKKAVWLEKEEKAKALREKQL-------QERRRRLEEQRLKAEQRRAA 195
+++R K ++ E+EEK EK QE++ +E+ + E +
Sbjct: 489 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 548
Query: 196 LEER---QRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
EE+ Q QK+ +ER E Q KKTW + + R
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR 586
Score = 32.7 bits (73), Expect = 1.4
Identities = 23/115 (20%), Positives = 51/115 (44%), Gaps = 18/115 (15%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAK----------ALREKQLQER 178
+QE K + +E++ R + + ++ E+EEK + EK+ QE+
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574
Query: 179 RRRL--------EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAE 225
++ EE+R++ +++ EE ++ E+ + E +Q +K W +
Sbjct: 575 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQ 629
Score = 32.3 bits (72), Expect = 1.9
Identities = 18/104 (17%), Positives = 52/104 (50%), Gaps = 2/104 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL--EEQR 186
+QE K + K+ ++ + R + ++ +E+K +E+Q+QE+ ++ +E++
Sbjct: 304 EQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
++ ++ + +E + + EK E ++ ++ W + + R
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407
Score = 32.3 bits (72), Expect = 1.9
Identities = 20/105 (19%), Positives = 52/105 (49%), Gaps = 8/105 (7%)
Query: 129 KQEVKKAGERHKL---AKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL-EE 184
+++ ++ E+ K+ ++ REE+ KK ++++ K E++++ER +++ EE
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKT----RDQEEKMQEEERIREREKKMREE 462
Query: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
+ EQ ++ + ++ KE + + +K W + + Q
Sbjct: 463 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Score = 32.3 bits (72), Expect = 1.9
Identities = 21/91 (23%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 130 QEVKKAGERHKLA---KERREERAKYLAAKKAVWLEKE-----EKAKALREKQLQERRRR 181
QE K G+ K+ ++ R + K ++ +W ++E E+ +E++++E+ +
Sbjct: 799 QEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQG 858
Query: 182 LEEQRLKAEQRRAALEERQRQKLEKNKERYE 212
EE+ + E++ EE+ R++ EK + + E
Sbjct: 859 QEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 31.2 bits (69), Expect = 4.2
Identities = 24/110 (21%), Positives = 51/110 (46%), Gaps = 8/110 (7%)
Query: 129 KQEVKKAGERHKLAKERR---EERAKYLAAKKAVWL-----EKEEKAKALREKQLQERRR 180
+QE K + K+ ++ E+ K ++ +W E++EK + Q QE+ +
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 181 RLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
EE+ + E+ +E++++ ++ K R E +++ KK E R
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Score = 30.4 bits (67), Expect = 7.2
Identities = 34/171 (19%), Positives = 68/171 (39%), Gaps = 11/171 (6%)
Query: 612 EQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQER 671
E+ +E L+ R+ EE + AE + + + E + K + E+ +
Sbjct: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
Query: 672 LQKQKEEAEARSREEAERQRLEREKHFQQQEQE----RQERRKRLEEIMKRTRKSEVSET 727
+ + E ++ RE+ + ++QE RQE R R +E R ++ ++
Sbjct: 260 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQ 319
Query: 728 KQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
+++ +E E + E R Q+E +Q++E E W K
Sbjct: 320 EKRLREQEKELREQEKELREQKELRE---QEEQMQEQE----EKMWEQEEK 363
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/175 (29%), Positives = 101/175 (57%), Gaps = 8/175 (4%)
Query: 598 EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQE 657
E + L E+ ++ REQ++ EQE ++Q + +K +E+ RE E + R+ E +E++
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 658 AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMK 717
RE+ Q ++++ER+ +Q E R RE+ ER R E+EK ++Q+E+ ++E R R E K
Sbjct: 347 MREQEQKMRDQEERMWEQDE----RLREKEERMR-EQEKMWEQEEKMQEEERIRERE--K 399
Query: 718 RTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQ 772
+ R+ E + +Q++ ++ N E + + R P QKE + ++E + ++ +
Sbjct: 400 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE-QKEKLWEQEKMQEQEE 453
Score = 74.7 bits (182), Expect = 3e-13
Identities = 48/196 (24%), Positives = 107/196 (54%), Gaps = 15/196 (7%)
Query: 596 REEATRLLAEKR-----RQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
RE+ R+ +K+ + RE+++ +EQE++ +++++MREE+ RE E + E E
Sbjct: 517 REKEERMREQKKMWQQEEKMREEKKTQEQEKKTW-DQEEKMREEERMREREKKMREEEEM 575
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSRE--EAERQRLEREKHFQQQEQE---- 704
R +E++ +E+ + +E++E++ +Q+E+ + + + E E + E+E+ + QEQE
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW 635
Query: 705 RQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKE 764
QE + + +E ++ ++ E ++K +E G E ++ E + G +++ ++E
Sbjct: 636 EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE-EKMREQEEKMQGQEEKMREQE 694
Query: 765 EPI--PQEPQWSLPSK 778
E + +E W K
Sbjct: 695 EKMRGQEEKMWGQEEK 710
Score = 73.9 bits (180), Expect = 6e-13
Identities = 62/203 (30%), Positives = 106/203 (52%), Gaps = 21/203 (10%)
Query: 594 TDREEATRLLAEKRRQAREQREREE----QERRLQAERDK-RMREEQLAREAEARAEREA 648
T +EE R E R Q ++ R++EE QE RL+ + K R +EE++ R+ + E+E
Sbjct: 231 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 649 EARRREEQEAREKAQAEQEEQERLQKQKE-EAEARSREEAER-----QRL-EREKHFQQQ 701
E R +E++ +K EQEEQ + Q++K E E + RE+ E+ +RL E+EK ++Q
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350
Query: 702 EQERQERRKRLEEIMKRTRKSEVSETKQ-----KQDSKEANANGSSPEPVKAVEARSPGL 756
EQ+ +++ +R+ E +R R+ E +Q +++ + E E +
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMRE 410
Query: 757 QKEAVQKEEPIPQEPQWSLPSKE 779
Q+E +QK+E E W KE
Sbjct: 411 QEEKMQKQE----ENMWEQEEKE 429
Score = 70.5 bits (171), Expect = 6e-12
Identities = 40/135 (29%), Positives = 83/135 (61%), Gaps = 3/135 (2%)
Query: 598 EATRLLAEKRRQAREQRERE-EQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
E + + E+ ++ R+Q ER EQ+ RL+ E+++RMRE++ E E + + E R R E+
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLR-EKEERMREQEKMWEQEEKMQEEERIRER-EK 399
Query: 657 EAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIM 716
+ RE+ + +E++E++QKQ+E + +E ++QRL +K ++++ QE+ +++ E
Sbjct: 400 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 459
Query: 717 KRTRKSEVSETKQKQ 731
++ R E ++K+
Sbjct: 460 EKIRDQEEMWGQEKK 474
Score = 69.7 bits (169), Expect = 1e-11
Identities = 45/182 (24%), Positives = 93/182 (51%), Gaps = 7/182 (3%)
Query: 605 EKRRQAREQREREEQERRLQAER----DKRMREEQLAREAEARA-EREAEARRREEQEAR 659
E+R +++R RE++ER + ++ +++MREE+ +E E + ++E + R E R
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565
Query: 660 EKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRT 719
EK E+EE R Q++K + + E E + E+E+ Q+QE++ E+ +++ E +
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 720 RKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGL--QKEAVQKEEPIPQEPQWSLPS 777
+ E E +Q+ K E + + + + Q+E +Q +E +E + +
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 778 KE 779
+E
Sbjct: 686 QE 687
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/208 (28%), Positives = 110/208 (52%), Gaps = 31/208 (14%)
Query: 593 TTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
T D+EE R E+R + RE++ REE+E + E + +EE++ + E E+E + +
Sbjct: 549 TWDQEEKMR--EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQE 606
Query: 653 REE-----------QEAREKAQAEQE----EQERLQKQKE---EAEARSREEAERQRLER 694
+EE QE +K Q ++E ++E++Q+Q+E E E + RE+ E+ R E+
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR-EQ 665
Query: 695 EKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSP 754
E+ Q QE++ +E+ ++++ ++ ++ E ++K +E G E + E +
Sbjct: 666 EEKMQGQEEKMREQEEKMQ-----GQEEKMREQEEKMRGQEEKMWGQE-EKMWGQEEKMW 719
Query: 755 GLQKEAVQKEEPI---PQEPQWSLPSKE 779
G Q+E +KEE I ++ Q LP E
Sbjct: 720 G-QEEMREKEERIRDQKEKMQERLPEHE 746
Score = 68.2 bits (165), Expect = 3e-11
Identities = 46/186 (24%), Positives = 98/186 (52%), Gaps = 3/186 (1%)
Query: 596 REEATRLLAEKRRQAREQREREEQERRLQAERDKRMRE-EQLAREAEARAEREAEARRRE 654
RE+ ++ ++ + ++++ +QE R+ E+D+R+RE E+ RE + ++E + R +
Sbjct: 482 REQEDQMWEQEEKMRDQEQKMWDQEERMW-EQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEE 714
+ + +EK +QEE+ R +++ E E + REE E R + EK +Q+E+ R++ K E+
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 715 IMKRTRKSE-VSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQW 773
K + E + E ++K +E E + + Q+E + ++E +E +
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE 660
Query: 774 SLPSKE 779
+ +E
Sbjct: 661 KMREQE 666
Score = 67.4 bits (163), Expect = 5e-11
Identities = 43/184 (23%), Positives = 91/184 (49%), Gaps = 6/184 (3%)
Query: 595 DREEATRLLAEKRRQARE----QREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650
+ EE R EK ++ E Q E+E Q++RL +++K +E++ + E E+E +
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462
Query: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQ--ERQER 708
R +EE +EK QE+ + Q E E + R++ ++ + E+ ++Q E+ E++ER
Sbjct: 463 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER 522
Query: 709 RKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIP 768
+ +++ ++ K + Q+Q+ K + E + E ++E + +E+
Sbjct: 523 MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 582
Query: 769 QEPQ 772
+ Q
Sbjct: 583 MQEQ 586
Score = 66.6 bits (161), Expect = 9e-11
Identities = 35/146 (23%), Positives = 86/146 (58%), Gaps = 8/146 (5%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
D+EE + ++++ R+++ RE++++ + E R +E+++ + E E++ R +E
Sbjct: 464 DQEE---MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE 520
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQR-----LEREKHFQQQEQERQERR 709
E+ +K +QEE+ R +K+ +E E ++ ++ E+ R EREK +++E+ +E+
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 580
Query: 710 KRLEEIMKRTRKSEVSETKQKQDSKE 735
++++E ++ R+ E +Q++ +E
Sbjct: 581 EKMQEQEEKMREQEEKMWEQEEKMQE 606
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/174 (26%), Positives = 96/174 (55%), Gaps = 9/174 (5%)
Query: 598 EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQE 657
E L EK + REQ++ +QE +++ E+ + +E++ + E RE E R E++
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM--REEERMREREKK 568
Query: 658 AREKAQAEQEEQERLQKQKE---EAEARSREEAERQRLEREKHFQQQEQ--ERQERRKRL 712
RE+ + +E++E++Q+Q+E E E + E+ E+ + + EK ++Q+E+ E++E K
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628
Query: 713 E-EIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEE 765
E E M ++ ++ E ++K +E E ++ E + G +++ ++EE
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMR-EQEEKMREQEEKMQGQEEKMREQEE 681
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/150 (31%), Positives = 83/150 (55%), Gaps = 13/150 (8%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMRE-EQLAREAEARAE------REAE 649
+E + E+ + REQ E+ ++ E++K+MRE EQ R+ E R RE E
Sbjct: 313 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 372
Query: 650 ARRREEQ---EAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQ 706
R RE++ E EK Q E+ +ER +K +EE E RE+ E+ + + E ++Q+E+E Q
Sbjct: 373 ERMREQEKMWEQEEKMQEEERIREREKKMREEEET-MREQEEKMQKQEENMWEQEEKEWQ 431
Query: 707 ERR--KRLEEIMKRTRKSEVSETKQKQDSK 734
++R ++ E++ ++ + E E +Q+ K
Sbjct: 432 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Score = 64.7 bits (156), Expect = 3e-10
Identities = 52/180 (28%), Positives = 92/180 (51%), Gaps = 10/180 (5%)
Query: 598 EATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ- 656
E L EK + REQ + EQE ++Q E R RE+++ E E E+E + +++EE
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 422
Query: 657 -EAREKAQAEQ---EEQERL--QKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK 710
E EK +Q E++E+L Q++ +E E + E+ E+ R + E Q+++ RQE+ +
Sbjct: 423 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 482
Query: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
E+ M + + ++ D +E E ++ E R QK+ Q+EE + +E
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEE--RMWEQDERLREKEERMRE-QKKMWQQEEKMREE 539
Score = 62.8 bits (151), Expect = 1e-09
Identities = 45/184 (24%), Positives = 90/184 (48%), Gaps = 2/184 (1%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
+E + E+ + R+Q E QE+++ + R +E+Q+ + E ++E + +EE+
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 657 E-AREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEI 715
+++ E+EE+ R QK+ + E + REE + Q E+ K + Q+E+ R+E R R E
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEK-KTWDQEEKMREEERMREREK 567
Query: 716 MKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSL 775
R + + E ++K +E + + E +K Q+E+ QE + +
Sbjct: 568 KMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKM 627
Query: 776 PSKE 779
+E
Sbjct: 628 QEQE 631
Score = 61.2 bits (147), Expect = 4e-09
Identities = 43/179 (24%), Positives = 89/179 (49%), Gaps = 8/179 (4%)
Query: 603 LAEKRRQAREQRER-EEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREK 661
+ E+ Q EQ E+ +QE+++ + ++ +++ RE E R + + ++EE+ EK
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 662 AQAEQEEQ--ERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRT 719
EQE++ ++ +K +EE R RE+ R+ E + +++ QE++E+ + EE M
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE- 599
Query: 720 RKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
++ ++ E ++K +E E + Q+E +Q++E E W K
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE----EKMWEQEEK 654
Score = 60.5 bits (145), Expect = 6e-09
Identities = 46/199 (23%), Positives = 97/199 (48%), Gaps = 23/199 (11%)
Query: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQ 656
E+ ++ E+R + RE++ REE+E + E + +EE + + E +++ ++E+
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Query: 657 EAREKAQAEQ----EEQERLQKQKE---------------EAEARSREEAERQRLEREKH 697
+EK Q ++ E++E+++ Q+E E E + E+ E+ R + +K
Sbjct: 443 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502
Query: 698 FQQQEQ--ERQERRKRLEEIMKRTRKSEVSETKQKQDSK--EANANGSSPEPVKAVEARS 753
+ Q+E+ E+ ER + EE M+ +K E K +++ K E E E R
Sbjct: 503 WDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM 562
Query: 754 PGLQKEAVQKEEPIPQEPQ 772
+K+ ++EE + ++ +
Sbjct: 563 REREKKMREEEEMMREQEE 581
Score = 60.1 bits (144), Expect = 8e-09
Identities = 47/197 (23%), Positives = 104/197 (52%), Gaps = 19/197 (9%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
++E + L E++ + EQ + +EQE ++ E+++++R+++ E + R+ + R +E
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIW-EQEEKIRDQEEMWGQEKKMWRQEKMREQE 485
Query: 655 EQ------EAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQER--- 705
+Q + R++ Q +++ER+ +Q E R RE+ ER R E++K +QQ+E+ R
Sbjct: 486 DQMWEQEEKMRDQEQKMWDQEERMWEQDE----RLREKEERMR-EQKKMWQQEEKMREEK 540
Query: 706 --QERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQK 763
QE+ K+ + ++ R+ E ++K+ +E E ++ E + +++ ++
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 764 EEPI--PQEPQWSLPSK 778
EE + +E W K
Sbjct: 601 EEKMQEQEEKMWEQEEK 617
Score = 60.1 bits (144), Expect = 8e-09
Identities = 34/154 (22%), Positives = 75/154 (48%), Gaps = 3/154 (1%)
Query: 595 DREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRRE 654
++EE + EK + E+ +E+E ++Q + + +E+ +E E + + E R +
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 655 EQEARE---KAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKR 711
E++ RE K Q ++E+ +++ + E + RE+ E+ R + EK + Q+E+ + K
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKM 718
Query: 712 LEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745
+ R ++ + + K+K + EP
Sbjct: 719 WGQEEMREKEERIRDQKEKMQERLPEHEERCSEP 752
Score = 58.9 bits (141), Expect = 2e-08
Identities = 45/191 (23%), Positives = 100/191 (52%), Gaps = 16/191 (8%)
Query: 598 EATRLLAEKRRQAREQRERE-EQERRLQAERDKRMREEQLA--REAEARAEREAEARRRE 654
E + ++ ++ +Q ER EQ+ RL+ E+++RMRE++ +E + R E++ + + ++
Sbjct: 490 EQEEKMRDQEQKMWDQEERMWEQDERLR-EKEERMREQKKMWQQEEKMREEKKTQEQEKK 548
Query: 655 EQEAREKAQAEQEEQERLQKQKEEAEA-RSREE-----AERQRLEREKHFQQQEQERQER 708
+ EK + E+ +ER +K +EE E R +EE E+ R + EK ++Q+E+ +++
Sbjct: 549 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQE 608
Query: 709 RKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIP 768
K E+ K + E + +++++ + K E Q+E ++++E
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE------QEEKMREQEEKM 662
Query: 769 QEPQWSLPSKE 779
+E + + +E
Sbjct: 663 REQEEKMQGQE 673
Score = 58.2 bits (139), Expect = 3e-08
Identities = 44/145 (30%), Positives = 77/145 (53%), Gaps = 8/145 (5%)
Query: 593 TTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARR 652
T EE + AE + + R E E+ E +L + KR E + + E
Sbjct: 179 TITNEELKKKNAELQEKLR-LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMW 237
Query: 653 REEQEAREKAQAEQEEQERLQKQKE---EAEARSREEAERQRLEREKHFQQQEQERQERR 709
R+E+E RE+ + ++++E++ +Q+E E E + RE+ E+ R +EK ++QE+E +E+
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR-RQEKRLREQEKELREQE 296
Query: 710 KRLEEIMKRTRKSEVSETKQKQDSK 734
K L E K+ R+ E E Q+Q+ K
Sbjct: 297 KELRE-QKKLREQE--EQMQEQEEK 318
Score = 40.4 bits (93), Expect = 0.007
Identities = 21/94 (22%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 137 ERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
E + +E RE+ K ++ +W ++E + + + QE + R +E+RL+ +++
Sbjct: 235 EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELRE 294
Query: 197 EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+E++ ++ +K +E+ E +Q +K W + + R
Sbjct: 295 QEKELREQKKLREQ-EEQMQEQEEKMWEQEEKMR 327
Score = 40.4 bits (93), Expect = 0.007
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 11/113 (9%)
Query: 129 KQEVKKAGERHKLAKERR-EERAKYLAAKKAVWLEKEEKAKALREK------QLQERRRR 181
+QE K + K+ +E R ER K + ++ + E+EEK + EK ++ E+ +
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK 603
Query: 182 LEEQRLKA-EQRRAALEERQRQKLEKNKE---RYEAAIQRSVKKTWAEIRQQR 230
++EQ K EQ E+ + K+++ +E E +Q +K W + + R
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR 656
Score = 40.0 bits (92), Expect = 0.009
Identities = 26/106 (24%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
++E+++ ++ + +E+ + + L ++ E+EEK + +EK+L+E+ + L EQ +
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR-QEKRLREQEKELREQEKE 298
Query: 189 A-EQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSW 233
EQ++ +E Q Q+ E+ E ++ +K W RQ+ W
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMW---RQEERLW 341
Score = 39.7 bits (91), Expect = 0.012
Identities = 23/102 (22%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+QE K + +E++ R + + ++ E+EEK + +E+++ ++ R+ EQ +
Sbjct: 457 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD-QEQKMWDQEERMWEQDER 515
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
++ + E+++ ++ K R E Q KKTW + + R
Sbjct: 516 LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR 557
Score = 39.3 bits (90), Expect = 0.015
Identities = 23/103 (22%), Positives = 53/103 (51%), Gaps = 7/103 (6%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERR------RRL 182
+Q++ ER ER E+ + + +K +W ++EEK + ++ Q QE++ +
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMW-QQEEKMREEKKTQEQEKKTWDQEEKMR 557
Query: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAE 225
EE+R++ +++ EE ++ E+ + E ++ +K W +
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Score = 38.9 bits (89), Expect = 0.020
Identities = 32/121 (26%), Positives = 59/121 (48%), Gaps = 18/121 (14%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKE---------EKAKALREKQLQERR 179
+Q+++ ER ER E+ + + ++ +W ++E E+ K +RE++ E
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEE--ETM 408
Query: 180 RRLEEQRLKAEQRRAALEER--QRQKLEKNKERY--EAAIQRSVKKTWAE---IRQQRWS 232
R EE+ K E+ EE+ Q+Q+L + KE+ + +Q +K W + IR Q
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 468
Query: 233 W 233
W
Sbjct: 469 W 469
Score = 38.5 bits (88), Expect = 0.026
Identities = 25/107 (23%), Positives = 53/107 (49%), Gaps = 8/107 (7%)
Query: 129 KQEVKKAGERHKL---AKERREERAKYLAAKKAVWLEKE---EKAKALRE--KQLQERRR 180
+QE K + +L K+ RE+ K ++ +W + E EK + +RE K ++ +
Sbjct: 328 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Query: 181 RLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIR 227
EE+R++ +++ EE ++ E+ ++ E + +K W + R
Sbjct: 388 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 434
Score = 38.5 bits (88), Expect = 0.026
Identities = 22/103 (21%), Positives = 51/103 (49%), Gaps = 2/103 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
K+E + ++ +E+ E K +K W ++EEK + + +E++ R EE+ ++
Sbjct: 519 KEERMREQKKMWQQEEKMREEKKTQEQEKKTW-DQEEKMREEERMREREKKMREEEEMMR 577
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRW 231
++ + +E + ++ E+ E +Q +K W E ++ W
Sbjct: 578 EQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW-EQEEKMW 619
Score = 37.0 bits (84), Expect = 0.076
Identities = 23/97 (23%), Positives = 47/97 (48%), Gaps = 2/97 (2%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+QE E +ER ER K + ++ E+EEK + E ++ + ++QRL
Sbjct: 377 EQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP 436
Query: 189 AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAE 225
++ + +E+ +++ EK E+ E R ++ W +
Sbjct: 437 EQKEKLWEQEKMQEQEEKIWEQEEKI--RDQEEMWGQ 471
Score = 36.6 bits (83), Expect = 0.100
Identities = 22/94 (23%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 144 ERREERAKYL-------AAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAAL 196
+R+ ERAK+L ++ +W ++EE + ++ + QE + +E+RL+ ++ +
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 197 EERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
+E + ++ EK E ++ K E+R+Q+
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEK----ELREQK 303
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/110 (24%), Positives = 58/110 (52%), Gaps = 10/110 (9%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL--------QERRR 180
++E+++ + + K+ RE+ + ++ +W E+EEK + EK QE++
Sbjct: 289 EKELREQEKELREQKKLREQEEQMQEQEEKMW-EQEEKMREQEEKMWRQEERLWEQEKQM 347
Query: 181 RLEEQRLK-AEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQ 229
R +EQ+++ E+R +ER R+K E+ +E+ + Q + IR++
Sbjct: 348 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397
Score = 35.8 bits (81), Expect = 0.17
Identities = 20/85 (23%), Positives = 48/85 (56%), Gaps = 6/85 (7%)
Query: 128 TKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRL 187
T+++ KK ++ + K R EER + K + +EE+ +E+++QE+ ++ EQ
Sbjct: 542 TQEQEKKTWDQEE--KMREEERMREREKK----MREEEEMMREQEEKMQEQEEKMREQEE 595
Query: 188 KAEQRRAALEERQRQKLEKNKERYE 212
K ++ ++E++ + E+ ++ +E
Sbjct: 596 KMWEQEEKMQEQEEKMWEQEEKMWE 620
Score = 35.4 bits (80), Expect = 0.22
Identities = 21/87 (24%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 129 KQEVKKAGERHKLAKER---REERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ 185
+QE K + K+ ++ +E+ K ++ +W ++EE +E+ + E+ +++EQ
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 186 RLKAEQRRAALEERQRQKLEKNKERYE 212
E++ EE+ R++ EK +E+ E
Sbjct: 645 ----EEKMWEQEEKMREQEEKMREQEE 667
Score = 34.7 bits (78), Expect = 0.38
Identities = 20/83 (24%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL-QERRRRLEEQRL 187
++++++ E+ + +E+ E+ + + ++ E+EEK + EK QE + +E+++
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKM 718
Query: 188 KAEQRRAALEERQRQKLEKNKER 210
++ EER R + EK +ER
Sbjct: 719 WGQEEMREKEERIRDQKEKMQER 741
Score = 34.3 bits (77), Expect = 0.50
Identities = 29/111 (26%), Positives = 57/111 (51%), Gaps = 12/111 (10%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQL-QERRRRLEEQRL 187
+QE K + K+ ++ EE K ++ +W E+EEK + EK QE + R +E+++
Sbjct: 606 EQEEKMWEQEEKMWEQ--EEEDKMQEQEEMMW-EQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 188 K-AEQRRAALEERQRQKLEKNKERYEAAIQRSVK------KTWAEIRQQRW 231
+ E++ EE+ R++ EK + + E ++ K K W + ++ W
Sbjct: 663 REQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ-EEKMW 712
Score = 33.5 bits (75), Expect = 0.85
Identities = 24/111 (21%), Positives = 54/111 (48%), Gaps = 9/111 (8%)
Query: 129 KQEVKKAGERHKL--AKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQR 186
+QE K + K+ +ER E+ K + ++ ++EE+ E+ ++ R E+++
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 380
Query: 187 LKAEQRRAALEERQRQKLEKNKE------RYEAAIQRSVKKTWAEIRQQRW 231
+ ++ + EER R++ +K +E E +Q+ + W E ++ W
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW-EQEEKEW 430
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/104 (17%), Positives = 52/104 (50%), Gaps = 2/104 (1%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL--EEQR 186
+QE K + K+ ++ + R + ++ +E+K +E+Q+QE+ ++ +E++
Sbjct: 266 EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEK 325
Query: 187 LKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
++ ++ + +E + + EK E ++ ++ W + + R
Sbjct: 326 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 369
Score = 32.3 bits (72), Expect = 1.9
Identities = 31/149 (20%), Positives = 65/149 (43%), Gaps = 20/149 (13%)
Query: 634 EQLAREAEA------RAEREAEARRREEQEAREKAQAEQEEQERLQ------KQKEEAEA 681
E+L +E +A R E +++ E +EK + + E+ +Q K+K E
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAK 221
Query: 682 RSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGS 741
+ + L+ E Q++E QE++ R +E ++ + E + K +E
Sbjct: 222 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE------ 275
Query: 742 SPEPVKAVEARSPGLQKEAVQKEEPIPQE 770
E ++ E R +KE ++E+ + ++
Sbjct: 276 --EKMRRQEKRLREQEKELREQEKELREQ 302
Score = 32.3 bits (72), Expect = 1.9
Identities = 25/101 (24%), Positives = 50/101 (49%), Gaps = 15/101 (14%)
Query: 143 KERREERAKYLAAKKAVWLEKE----------EKAKALREKQLQERRRRLEEQRLKA--- 189
KE+ E+ K ++ +W ++E ++ K R+++++E+ ++ EQ K
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Query: 190 EQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQR 230
EQ+ EER ++ E+ +E+ E R KK W + + R
Sbjct: 499 EQKMWDQEERMWEQDERLREKEER--MREQKKMWQQEEKMR 537
Score = 32.0 bits (71), Expect = 2.5
Identities = 21/82 (25%), Positives = 43/82 (52%), Gaps = 11/82 (13%)
Query: 129 KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLK 188
+QE K G+ K+ RE+ K ++ +W +EEK EK + R +E+R++
Sbjct: 678 EQEEKMQGQEEKM----REQEEKMRGQEEKMW-GQEEKMWGQEEKMWGQEEMREKEERIR 732
Query: 189 AEQRRAALEERQRQKLEKNKER 210
++ E+ +++L +++ER
Sbjct: 733 DQK------EKMQERLPEHEER 748
Score = 31.2 bits (69), Expect = 4.2
Identities = 42/173 (24%), Positives = 77/173 (44%), Gaps = 15/173 (8%)
Query: 612 EQREREEQERRLQAERDKRMREEQLAREAEARAE-REAEARRREEQEAREKAQAEQEEQE 670
E+ +E L+ R+ EE + AE + + R AE+ + E Q ++ + + E +
Sbjct: 162 EELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAK 221
Query: 671 RLQKQKEEAEARSREEAERQRLE-REKHFQQQEQE----RQERRKRLEEIMKRTRKSEVS 725
L Q + + EE RQ E RE+ + ++QE RQE R R +E R ++ ++
Sbjct: 222 FLLPQVQTNTLQ--EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR 279
Query: 726 ETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSK 778
+++ +E E + + R Q+E +Q++E E W K
Sbjct: 280 RQEKRLREQEKELREQEKELREQKKLRE---QEEQMQEQE----EKMWEQEEK 325
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 82.0 bits (201), Expect = 2e-15
Identities = 82/382 (21%), Positives = 147/382 (38%), Gaps = 45/382 (11%)
Query: 409 ASPVQKKEKKDKERENEKEKSALARER-----SLKKRQSLPASPRARLSASTASELSPKS 463
A+ + + D + + + S L R+ S+ KR +S + S S + E + +S
Sbjct: 133 ATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
Query: 464 KARPSSPS----TSWHRPASPCPSPGP-GHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ S T + A P GP G K PS + + + E +
Sbjct: 193 SSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMAR 252
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPP 578
SA+ S S + K+ PA P P P P+ E+PP+ + +D+
Sbjct: 253 SASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS------- 305
Query: 579 APAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR 638
D +E R+ KRR +RE E + RR Q E +R+RE++ +
Sbjct: 306 ----------------DSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQE--K 347
Query: 639 EAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHF 698
E + R A+ E +E+ E ++K+ + R + E E
Sbjct: 348 EEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELER 407
Query: 699 QQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPG--L 756
+ ++ ++ + E K +K + ++KQ +K P V+ RS G +
Sbjct: 408 EAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK--------PVKVERTRKRSEGFSM 459
Query: 757 QKEAVQKEEPIPQEPQWSLPSK 778
++ +K+EP +E L S+
Sbjct: 460 DRKVEKKKEPSVEEKLQKLHSE 481
Score = 47.4 bits (111), Expect = 6e-05
Identities = 49/278 (17%), Positives = 108/278 (38%), Gaps = 34/278 (12%)
Query: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPP----QKEQPPA 565
RK + ++ P ++ S+ + +EK S +P A P +K++ P+
Sbjct: 171 RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS 230
Query: 566 ETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQA 625
+ +D+ + P P + ++ + ++ K+ R R+ E+ L
Sbjct: 231 ASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK----PPRGRKPAEKPLPK 286
Query: 626 ERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSRE 685
R ++ + E+ + + ++ +E +R+ + K R+
Sbjct: 287 PRGRKPKPER--------------------PPSSSSSDSDSDEVDRISEWKR------RD 320
Query: 686 EAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745
EA R+ LE + +Q+E+ R+ R + EE +R +++ E ++ + EP
Sbjct: 321 EARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEP 380
Query: 746 VKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPAS 783
VK + G + EP + + + S + P S
Sbjct: 381 VKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQS 418
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/136 (28%), Positives = 58/136 (42%), Gaps = 14/136 (10%)
Query: 56 KNATSSKQLPLEPESPSGQVGP----RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPR- 110
K A S+ + +S + P R A S SS P G + A P
Sbjct: 226 KKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLP 285
Query: 111 --RSSQPSPTAVPASDSPPT-KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKA 167
R +P P P+S S + EV + E K R E R + L A++ E+EE+
Sbjct: 286 KPRGRKPKPERPPSSSSSDSDSDEVDRISEW----KRRDEARRRELEARRR--REQEEEL 339
Query: 168 KALREKQLQERRRRLE 183
+ LRE++ +E+ RR E
Sbjct: 340 RRLREQEKEEKERRRE 355
Score = 35.4 bits (80), Expect = 0.22
Identities = 52/236 (22%), Positives = 88/236 (37%), Gaps = 25/236 (10%)
Query: 3 SGPRAELGAGAPPAVVARTPPE-PRPSPEGDPSPPPPPMSALVPDTPPDTPPAM---KNA 58
S +++ PP R P E P P P G P P S+ D+ D + K
Sbjct: 262 SSSDSDVSVKKPPR--GRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRR 319
Query: 59 TSSKQLPLEPESPSGQVGP-RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSP 117
+++ LE Q R QE+ + R A R S S
Sbjct: 320 DEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEA--------ERGSGGSSG 371
Query: 118 TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQE 177
+ D P K+ K G + + E AKK+ + + R+ +E
Sbjct: 372 DELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE 431
Query: 178 RRRRLEEQRLKAEQRRAALEERQRQKLE------KNKERYEAAIQRSVKKTWAEIR 227
+R R EE+ +Q + ER R++ E K +++ E +++ ++K +EI+
Sbjct: 432 KRVRPEEK----QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIK 483
Score = 34.3 bits (77), Expect = 0.50
Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 23/160 (14%)
Query: 68 PESPSGQVGPRPAP---------PQEESPSSEAKSRGPTP-PAMGPRDARPPRRSSQPSP 117
PE + PR P P S+A S G P P R A SS S
Sbjct: 206 PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSD 265
Query: 118 TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKK--------AVWLEKEEKAKA 169
+ V P ++ +K + + K + E ++ + W ++E
Sbjct: 266 SDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEA--- 322
Query: 170 LREKQLQERRRRLEEQRLKAEQRRAALE-ERQRQKLEKNK 208
R ++L+ RRRR +E+ L+ + + E ER+R++ ++ +
Sbjct: 323 -RRRELEARRRREQEEELRRLREQEKEEKERRRERADRGE 361
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 82.0 bits (201), Expect = 2e-15
Identities = 82/382 (21%), Positives = 147/382 (38%), Gaps = 45/382 (11%)
Query: 409 ASPVQKKEKKDKERENEKEKSALARER-----SLKKRQSLPASPRARLSASTASELSPKS 463
A+ + + D + + + S L R+ S+ KR +S + S S + E + +S
Sbjct: 133 ATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSES 192
Query: 464 KARPSSPS----TSWHRPASPCPSPGP-GHTLPPKPPSPRGTTASPKGRVRRKEEAKESP 518
+ S T + A P GP G K PS + + + E +
Sbjct: 193 SSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMAR 252
Query: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPP 578
SA+ S S + K+ PA P P P P+ E+PP+ + +D+
Sbjct: 253 SASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS------- 305
Query: 579 APAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAR 638
D +E R+ KRR +RE E + RR Q E +R+RE++ +
Sbjct: 306 ----------------DSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQE--K 347
Query: 639 EAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHF 698
E + R A+ E +E+ E ++K+ + R + E E
Sbjct: 348 EEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELER 407
Query: 699 QQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPG--L 756
+ ++ ++ + E K +K + ++KQ +K P V+ RS G +
Sbjct: 408 EAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAK--------PVKVERTRKRSEGFSM 459
Query: 757 QKEAVQKEEPIPQEPQWSLPSK 778
++ +K+EP +E L S+
Sbjct: 460 DRKVEKKKEPSVEEKLQKLHSE 481
Score = 47.4 bits (111), Expect = 6e-05
Identities = 49/278 (17%), Positives = 108/278 (38%), Gaps = 34/278 (12%)
Query: 510 RKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPP----QKEQPPA 565
RK + ++ P ++ S+ + +EK S +P A P +K++ P+
Sbjct: 171 RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPS 230
Query: 566 ETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQA 625
+ +D+ + P P + ++ + ++ K+ R R+ E+ L
Sbjct: 231 ASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK----PPRGRKPAEKPLPK 286
Query: 626 ERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSRE 685
R ++ + E+ + + ++ +E +R+ + K R+
Sbjct: 287 PRGRKPKPER--------------------PPSSSSSDSDSDEVDRISEWKR------RD 320
Query: 686 EAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745
EA R+ LE + +Q+E+ R+ R + EE +R +++ E ++ + EP
Sbjct: 321 EARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEP 380
Query: 746 VKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPAS 783
VK + G + EP + + + S + P S
Sbjct: 381 VKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQS 418
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/136 (28%), Positives = 58/136 (42%), Gaps = 14/136 (10%)
Query: 56 KNATSSKQLPLEPESPSGQVGP----RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPR- 110
K A S+ + +S + P R A S SS P G + A P
Sbjct: 226 KKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLP 285
Query: 111 --RSSQPSPTAVPASDSPPT-KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKA 167
R +P P P+S S + EV + E K R E R + L A++ E+EE+
Sbjct: 286 KPRGRKPKPERPPSSSSSDSDSDEVDRISEW----KRRDEARRRELEARRR--REQEEEL 339
Query: 168 KALREKQLQERRRRLE 183
+ LRE++ +E+ RR E
Sbjct: 340 RRLREQEKEEKERRRE 355
Score = 35.4 bits (80), Expect = 0.22
Identities = 52/236 (22%), Positives = 88/236 (37%), Gaps = 25/236 (10%)
Query: 3 SGPRAELGAGAPPAVVARTPPE-PRPSPEGDPSPPPPPMSALVPDTPPDTPPAM---KNA 58
S +++ PP R P E P P P G P P S+ D+ D + K
Sbjct: 262 SSSDSDVSVKKPPR--GRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRR 319
Query: 59 TSSKQLPLEPESPSGQVGP-RPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSP 117
+++ LE Q R QE+ + R A R S S
Sbjct: 320 DEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEA--------ERGSGGSSG 371
Query: 118 TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQE 177
+ D P K+ K G + + E AKK+ + + R+ +E
Sbjct: 372 DELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE 431
Query: 178 RRRRLEEQRLKAEQRRAALEERQRQKLE------KNKERYEAAIQRSVKKTWAEIR 227
+R R EE+ +Q + ER R++ E K +++ E +++ ++K +EI+
Sbjct: 432 KRVRPEEK----QQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIK 483
Score = 34.3 bits (77), Expect = 0.50
Identities = 36/160 (22%), Positives = 64/160 (40%), Gaps = 23/160 (14%)
Query: 68 PESPSGQVGPRPAP---------PQEESPSSEAKSRGPTP-PAMGPRDARPPRRSSQPSP 117
PE + PR P P S+A S G P P R A SS S
Sbjct: 206 PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSD 265
Query: 118 TAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKK--------AVWLEKEEKAKA 169
+ V P ++ +K + + K + E ++ + W ++E
Sbjct: 266 SDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEA--- 322
Query: 170 LREKQLQERRRRLEEQRLKAEQRRAALE-ERQRQKLEKNK 208
R ++L+ RRRR +E+ L+ + + E ER+R++ ++ +
Sbjct: 323 -RRRELEARRRREQEEELRRLREQEKEEKERRRERADRGE 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.121 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,310,110
Number of Sequences: 37866
Number of extensions: 3237317
Number of successful extensions: 139481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2246
Number of HSP's successfully gapped in prelim test: 3640
Number of HSP's that attempted gapping in prelim test: 23013
Number of HSP's gapped (non-prelim): 54105
length of query: 841
length of database: 18,247,518
effective HSP length: 111
effective length of query: 730
effective length of database: 14,044,392
effective search space: 10252406160
effective search space used: 10252406160
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.