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Search of human proteins with 78000156
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000156 eukaryotic translation initiation factor 2B,
subunit 4 delta isoform 3 [Homo sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000156 eukaryotic translation initiation factor 2B, subunit... 1021 0.0
gi|78000158 eukaryotic translation initiation factor 2B, subunit... 1016 0.0
gi|187607323 eukaryotic translation initiation factor 2B, subuni... 1004 0.0
gi|4503503 eukaryotic translation initiation factor 2B, subunit ... 104 2e-22
gi|7657058 eukaryotic translation initiation factor 2B, subunit ... 87 4e-17
gi|72534748 translation initiation factor eIF-2B subunit alpha/b... 69 1e-11
gi|23943880 translation initiation factor eIF-2B subunit alpha/b... 65 2e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 44 4e-04
gi|157785645 SPEG complex locus [Homo sapiens] 42 0.001
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 40 0.004
gi|125656165 THO complex 2 [Homo sapiens] 40 0.005
gi|24308289 leukocyte receptor cluster (LRC) member 1 [Homo sapi... 40 0.005
gi|217035154 RCSD domain containing 1 [Homo sapiens] 39 0.009
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 38 0.020
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 38 0.020
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 38 0.020
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 38 0.020
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 38 0.020
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 38 0.020
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 38 0.020
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 38 0.020
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 38 0.026
gi|21361517 UBX domain protein 1 [Homo sapiens] 38 0.026
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 37 0.034
gi|224591430 Ly1 antibody reactive homolog [Homo sapiens] 37 0.034
gi|8923398 Ly1 antibody reactive homolog [Homo sapiens] 37 0.034
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 37 0.034
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap... 37 0.044
gi|116805342 human immunodeficiency virus type I enhancer bindin... 37 0.044
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 37 0.057
>gi|78000156 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 3 [Homo sapiens]
Length = 522
Score = 1021 bits (2640), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET 60
MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET
Sbjct: 1 MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET 60
Query: 61 GSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGE 120
GSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGE
Sbjct: 61 GSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGE 120
Query: 121 QGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFS 180
QGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFS
Sbjct: 121 QGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFS 180
Query: 181 HLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYT 240
HLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYT
Sbjct: 181 HLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYT 240
Query: 241 TPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELR 300
TPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELR
Sbjct: 241 TPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELR 300
Query: 301 AAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVV 360
AAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVV
Sbjct: 301 AAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVV 360
Query: 361 DSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTA 420
DSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTA
Sbjct: 361 DSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTA 420
Query: 421 QLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHAS 480
QLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHAS
Sbjct: 421 QLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHAS 480
Query: 481 LRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 522
LRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
Sbjct: 481 LRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 522
>gi|78000158 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 2 [Homo sapiens]
Length = 523
Score = 1016 bits (2628), Expect = 0.0
Identities = 522/523 (99%), Positives = 522/523 (99%), Gaps = 1/523 (0%)
Query: 1 MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET 60
MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET
Sbjct: 1 MAAVAVAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET 60
Query: 61 GSAVSAAQCQ-GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKG 119
GSAVSAAQCQ GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKG
Sbjct: 61 GSAVSAAQCQVGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKG 120
Query: 120 EQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLF 179
EQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLF
Sbjct: 121 EQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLF 180
Query: 180 SHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDY 239
SHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDY
Sbjct: 181 SHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDY 240
Query: 240 TTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSEL 299
TTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSEL
Sbjct: 241 TTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSEL 300
Query: 300 RAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVV 359
RAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVV
Sbjct: 301 RAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVV 360
Query: 360 VDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGT 419
VDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGT
Sbjct: 361 VDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGT 420
Query: 420 AQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHA 479
AQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHA
Sbjct: 421 AQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHA 480
Query: 480 SLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 522
SLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
Sbjct: 481 SLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 523
>gi|187607323 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 1 [Homo sapiens]
Length = 543
Score = 1004 bits (2597), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 70
DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ
Sbjct: 32 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 91
Query: 71 GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 130
GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP
Sbjct: 92 GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 151
Query: 131 STAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNS 190
STAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNS
Sbjct: 152 STAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNS 211
Query: 191 LTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRD 250
LTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRD
Sbjct: 212 LTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRD 271
Query: 251 LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK 310
LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK
Sbjct: 272 LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK 331
Query: 311 IVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRH 370
IVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRH
Sbjct: 332 IVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRH 391
Query: 371 TLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHN 430
TLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHN
Sbjct: 392 TLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHN 451
Query: 431 VPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDV 490
VPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDV
Sbjct: 452 VPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDV 511
Query: 491 TPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 522
TPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
Sbjct: 512 TPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 543
>gi|4503503 eukaryotic translation initiation factor 2B, subunit 1
alpha, 26kDa [Homo sapiens]
Length = 305
Score = 104 bits (259), Expect = 2e-22
Identities = 63/202 (31%), Positives = 107/202 (52%), Gaps = 8/202 (3%)
Query: 310 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 369
+I L+ I+ + I +G IL + S +V R+L+ A +RF V V +S+P L G+
Sbjct: 103 RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGK 162
Query: 370 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 429
++L H VP + +L A Y++ + V++GA ++ NG +++++GT Q+A+ A+A
Sbjct: 163 KMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ 222
Query: 430 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 489
N P V E++KF F N+ D PD + K L Q L+ + D
Sbjct: 223 NKPFYVVAESFKFVR-----LFPLNQQDVPDKFKYKAD---TLKVAQTGQDLKEEHPWVD 274
Query: 490 VTPPELVDLVITELGMIPCSSV 511
T P L+ L+ T+LG++ S+V
Sbjct: 275 YTAPSLITLLFTDLGVLTPSAV 296
>gi|7657058 eukaryotic translation initiation factor 2B, subunit 2
beta, 39kDa [Homo sapiens]
Length = 351
Score = 87.0 bits (214), Expect = 4e-17
Identities = 64/230 (27%), Positives = 114/230 (49%), Gaps = 13/230 (5%)
Query: 279 LNKEITSVGSSKREEEAKSELRAAIDRYVQEKIVL---AAQAISRFAYQKISNGDVILVY 335
L+K +TS G ++ ++L++ I + E +V + I+ A + I + +VI+
Sbjct: 109 LHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTI 168
Query: 336 GCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLP 395
G S V L+EA R+F V+V + P+ +G +L AG+ + + A V+
Sbjct: 169 GFSRTVEAFLKEA-ARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMS 227
Query: 396 EVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNE 455
V+KV++G +LANG++ + GT LAL A+ H+ P++VC +K + + ++
Sbjct: 228 RVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHK 287
Query: 456 LDDPDD-LQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELG 504
P++ L G+ L H V+D PPEL+ L I+ +G
Sbjct: 288 FVAPEEVLPFTEGD--ILEKVSVHCP------VFDYVPPELITLFISNIG 329
>gi|72534748 translation initiation factor eIF-2B subunit
alpha/beta/delta-like protein isoform 1 [Homo sapiens]
Length = 369
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/285 (24%), Positives = 130/285 (45%), Gaps = 46/285 (16%)
Query: 251 LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK 310
LV ++ +SFL RP + +M A + ++ V + + E E +E V+E+
Sbjct: 75 LVAFVRDKLSFLVTARPTAVNMARAAR----DLADVAAREAEREGATE------EAVRER 124
Query: 311 IVLAAQAI---------------SRFAYQKI--SNGDVILVYGCSS---------LVSRI 344
++ + + +R +++ S G V ++ C++ +
Sbjct: 125 VICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHCNTGALATAGYGTALGV 184
Query: 345 LQEAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASYLL--IPAASYVLPEVSKVL 401
++ + GR ++RP+ +G R T LV+ +PA+ + + AA+ VS V+
Sbjct: 185 IRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVV 244
Query: 402 LGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDD 461
+GA ++ANG ++VGT QLA+VA+ H +P V + R++T + E +
Sbjct: 245 VGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQE 304
Query: 462 LQCKRGEHVALANWQNHASLRLLNLVYDVTPPELV-DLVITELGM 505
L G +A + + N +DVTP +L+ +ITELG+
Sbjct: 305 LTDVNGVRIAA------PGIGVWNPAFDVTPHDLITGGIITELGV 343
>gi|23943880 translation initiation factor eIF-2B subunit
alpha/beta/delta-like protein isoform 2 [Homo sapiens]
Length = 322
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/174 (31%), Positives = 88/174 (50%), Gaps = 19/174 (10%)
Query: 345 LQEAWTEGRRFRVV---------VVDSRPWLEG-RHTLRSLVHAGVPASYLL--IPAASY 392
L E W E R R + V+++RP+ +G R T LV+ +PA+ + + AA+
Sbjct: 129 LCEHWEEHTRQRELPLRGPLGGTVLETRPYNQGARLTAFELVYEQIPATLITDSMVAAAM 188
Query: 393 VLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFV 452
VS V++GA ++ANG ++VGT QLA+VA+ H +P V + R++T +
Sbjct: 189 AHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEI 248
Query: 453 SNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELV-DLVITELGM 505
E +L G +A + + N +DVTP +L+ +ITELG+
Sbjct: 249 IIEERPGQELTDVNGVRIAA------PGIGVWNPAFDVTPHDLITGGIITELGV 296
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/148 (21%), Positives = 70/148 (47%), Gaps = 9/148 (6%)
Query: 33 KEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPRE-KVP 91
++ K ++E K + + EK P A S A+ + P +E +S ++ +P + K P
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 92 AG-------RSKAELRAERRAKQEAERALK-QARKGEQGGPPPKASPSTAGETPSGVKRL 143
++K+ + E ++ ++A+ +K +A+ E+ P KA + + S VK
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 144 PEYPQVDDLLLRRLVKKPERQQVPTRKD 171
+ P+ ++ K PE+ + P +++
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEE 729
Score = 39.7 bits (91), Expect = 0.007
Identities = 38/173 (21%), Positives = 74/173 (42%), Gaps = 18/173 (10%)
Query: 9 REDSGSGMKAELPPGPGAVGREMTK---EEKLQLRKEKKQQKKKRKEEKGAEPETGSAVS 65
+E++ S +A+ P + +E K E K +++E K + + EK P A S
Sbjct: 589 KEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS 648
Query: 66 AAQCQGPTRELPESGIQLGTP---------REKVPAGRSKAELRAERRAKQEAERALKQA 116
+ + P +E +S + +P + K P KAE ++ +AK + ++A
Sbjct: 649 PEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV---KAEAKSPEKAKSPVK---EEA 702
Query: 117 RKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTR 169
+ E+ P K + + S VK + P+ ++ K PE+ + P +
Sbjct: 703 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEK 755
Score = 38.5 bits (88), Expect = 0.015
Identities = 45/194 (23%), Positives = 77/194 (39%), Gaps = 63/194 (32%)
Query: 27 VGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETG------------------------- 61
V E+T+EE EK+ ++++ KEE+G E E
Sbjct: 466 VTEEVTEEE------EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519
Query: 62 ---SAVSAAQCQGPTRELPESGIQLGTP-REKVPA-----------------GRSKAELR 100
A S A+ + P +E +S ++ +P + K PA +S AE++
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK 579
Query: 101 AERRAKQEAERALK---QARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRL 157
+ +AK A+ K +A+ E+ P K + E S VK + P
Sbjct: 580 SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-------- 631
Query: 158 VKKPERQQVPTRKD 171
VK PE+ + PT+++
Sbjct: 632 VKSPEKAKSPTKEE 645
Score = 38.5 bits (88), Expect = 0.015
Identities = 35/171 (20%), Positives = 72/171 (42%), Gaps = 10/171 (5%)
Query: 8 VREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAA 67
V+E++ S +A+ P A K + + + K++ K E K PE A S A
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPE-KAKSPAKEEAKSPPEAKS--PEKEEAKSPA 576
Query: 68 QCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKG-------E 120
+ + P + + + +P E ++K+ ++ E ++ EA+ +K+ K E
Sbjct: 577 EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE 636
Query: 121 QGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKD 171
+ P K + + S K + P+ ++ K PE+ + P + +
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Score = 36.6 bits (83), Expect = 0.057
Identities = 40/171 (23%), Positives = 76/171 (44%), Gaps = 21/171 (12%)
Query: 6 VAVREDSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVS 65
V V+E + + P P ++ +K+E+ ++ K + +++KE +P+ S V
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE-SKVE 891
Query: 66 AAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQ---ARKGEQG 122
A +E E ++ TP ++ PA K E++ + + K++ E A K+ A+ E
Sbjct: 892 A------KKEEAEDKKKVPTPEKEAPA---KVEVKEDAKPKEKTEVAKKEPDDAKAKEPS 942
Query: 123 GPPPK--ASPSTAGETPSGVKRLPEYPQV------DDLLLRRLVKKPERQQ 165
P K A+P K+ E P+ DD L + KP+ ++
Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEK 993
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 21/138 (15%)
Query: 25 GAVGREMTKEEKLQLRKEKKQ--QKKKRKEEKG--------AEPETGSAVSAAQCQGPTR 74
G + R ++EE ++ + + Q+ E G + P+T AVS A Q P+
Sbjct: 499 GRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAAAQPPSP 558
Query: 75 ELPES-GIQLGTPREKVPAGRS------KAELRAERRAKQEAERALKQARKGEQGGPPPK 127
E G + G PR + PAGR+ + E+R + RA+++ R PPP
Sbjct: 559 SSAEKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSPV---PPPA 615
Query: 128 ASPSTA-GETPSGVKRLP 144
A P A + P G KR P
Sbjct: 616 ADPPEARTKAPPGRKREP 633
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/136 (27%), Positives = 57/136 (41%), Gaps = 26/136 (19%)
Query: 12 SGSGMKAELP-PGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 70
+ G+ LP P + +KE + Q ++ +KQ+K+++K+EK E E
Sbjct: 697 TAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQEKEREKE----------- 745
Query: 71 GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 130
R+ E REK R K E +++ K+ R L RK + GPP P
Sbjct: 746 ---RQKQEK------EREKQEKEREKQEKERQKQEKKAQGRKLSLRRKAD--GPP---GP 791
Query: 131 STAGETPSGVKRLPEY 146
G+ PS R Y
Sbjct: 792 HDGGDRPSAEARQDAY 807
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 40.0 bits (92), Expect = 0.005
Identities = 43/177 (24%), Positives = 70/177 (39%), Gaps = 20/177 (11%)
Query: 9 REDSGSGMKA------ELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGS 62
RE S G+KA P G + G + K +K++ K+K KE+K P T
Sbjct: 1231 RERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTP 1290
Query: 63 AVSAAQCQG---PTRELPESGIQLGTPREKVP-AGRSKAELRAERRAKQE--------AE 110
G P E P + +E+ P + + K + + E +AK E AE
Sbjct: 1291 EARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAE 1350
Query: 111 RALKQARKGEQGGPPPK--ASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQ 165
Q R+ E+ + A + E G ++ P + + R + +PER+Q
Sbjct: 1351 SKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQ 1407
>gi|24308289 leukocyte receptor cluster (LRC) member 1 [Homo
sapiens]
Length = 264
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 18/144 (12%)
Query: 22 PGPGAVG--REMTKEEKLQLR------KEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPT 73
PG G V RE+ +E K +R +EK+Q+K+++++ G G + + AQ Q P
Sbjct: 71 PGSGPVDLFRELLEEGKGVIRGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPW 130
Query: 74 RELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTA 133
+LP + G P P + K+ L R ++ + K+ G++G K +
Sbjct: 131 YQLPPG--RGGPPPGPAPDEKIKSRLDPLREMQKHLGK--KRQHGGDEGSRSRKEKEGSE 186
Query: 134 GETPSGVKRLPEYPQVDDLLLRRL 157
+ P E P +D L RL
Sbjct: 187 KQRPK------EPPSLDQLRAERL 204
Score = 30.4 bits (67), Expect = 4.1
Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 6/106 (5%)
Query: 19 ELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPE 78
+LPPG G +EK++ R + ++ +K +K + S + +G ++ P+
Sbjct: 132 QLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRKEKEGSEKQRPK 191
Query: 79 SGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGP 124
L +++ A R + E A R++ EA A Q R ++G P
Sbjct: 192 EPPSL----DQLRAERLRRE--AAERSRAEALLARVQGRALQEGQP 231
>gi|217035154 RCSD domain containing 1 [Homo sapiens]
Length = 416
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 14/102 (13%)
Query: 52 EEKGAEPETGSAVSAAQCQGPTRELPESG-----IQLGTPREKVPAGRSKAELRAERRAK 106
++ GA+ E G V ++ + P L G ++ P EK P RS + R K
Sbjct: 194 QQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPS-----RTEK 248
Query: 107 QEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQ 148
QE +RA ++A+ GE+ ++S G+ P+ + +PE PQ
Sbjct: 249 QEEDRATEEAKNGEKA---RRSSEEVDGQHPA-QEEVPESPQ 286
Score = 37.7 bits (86), Expect = 0.026
Identities = 38/148 (25%), Positives = 61/148 (41%), Gaps = 23/148 (15%)
Query: 13 GSGMKAELPPGPGAVGREMTKEEKLQLRK-----EKKQQKKKRKEEKGAEPETGSA---- 63
GS + +E G G R + EK LR+ EK+++ + +E K E S+
Sbjct: 215 GSPLSSEGAAGEGV--RTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVD 272
Query: 64 ----VSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKG 119
+ P PE+ + G+PRE+ PAG E E+ + + ER +
Sbjct: 273 GQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGE---EAEMEKATEVKGERV-----QN 324
Query: 120 EQGGPPPKASPSTAGETPSGVKRLPEYP 147
E+ GP + + E + VK P P
Sbjct: 325 EEVGPEHDSQETKKLEEGAAVKETPHSP 352
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 38.1 bits (87), Expect = 0.020
Identities = 44/197 (22%), Positives = 72/197 (36%), Gaps = 24/197 (12%)
Query: 22 PGP-GAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESG 80
PGP G G ++ EE + R + + K+ GA +T R +G
Sbjct: 126 PGPLGQKGLRISAEETVA-RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
Query: 81 IQLGTPREKVPAGRSKAELRAERRAKQEA------ERALKQARKGEQGG----------- 123
++G PR P+ R + R++ A E + R+ GG
Sbjct: 185 TEVGLPRP-APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
Query: 124 --PPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSH 181
P +SP+ +G + G R P +P + ++ P Q P RKD + S
Sbjct: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP--QVTPPRKDAAPALGPLSS 301
Query: 182 LPQYSRQNSLTQFMSIP 198
P + S T+ +P
Sbjct: 302 SPLATPSPSGTKARPVP 318
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 38.1 bits (87), Expect = 0.020
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 13/90 (14%)
Query: 29 REMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPRE 88
++ TKE + + KE++++K+KRK +K E E RE E + E
Sbjct: 43 KKKTKETEKRKEKEEEEKKRKRKRKKKKEEEE-------------REEEEEEEEEEKEEE 89
Query: 89 KVPAGRSKAELRAERRAKQEAERALKQARK 118
+ GR + + + RR ++E E+ K+ RK
Sbjct: 90 EKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 38.1 bits (87), Expect = 0.020
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 14 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 70
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 71 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 121
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 122 GGPPPKASPSTAGETPSG 139
G P ST G P G
Sbjct: 424 GKSPQVKPASTMGMGPLG 441
Score = 33.1 bits (74), Expect = 0.63
Identities = 27/111 (24%), Positives = 44/111 (39%), Gaps = 8/111 (7%)
Query: 30 EMTKEEKLQLRKEKKQQKKKRKEEKGAEP----ETGSAVSAAQCQGPTRELPESGIQLGT 85
E+ EK+ L+ K KGA P + G+ S + P + S +
Sbjct: 213 EVKASEKI-LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 271
Query: 86 PREKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGGPPPKASPSTA 133
E+ PA ++ + +A + Q + A + RKG PP K P+ A
Sbjct: 272 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Score = 29.3 bits (64), Expect = 9.2
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 19 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 68
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1344 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1398
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 38.1 bits (87), Expect = 0.020
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 14 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 70
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 71 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 121
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 122 GGPPPKASPSTAGETPSG 139
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 37.0 bits (84), Expect = 0.044
Identities = 31/130 (23%), Positives = 49/130 (37%), Gaps = 11/130 (8%)
Query: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEP----ETGSAVSA 66
+ GS + E P G R K + L+ K KGA P + G+ S
Sbjct: 274 EEGSESEEEAPAGT----RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 67 AQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGG 123
+ P + S + E+ PA ++ + +A + Q + A + RKG
Sbjct: 330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 389
Query: 124 PPPKASPSTA 133
PP K P+ A
Sbjct: 390 PPGKTGPAVA 399
Score = 29.3 bits (64), Expect = 9.2
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 19 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 68
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1383 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1437
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 38.1 bits (87), Expect = 0.020
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 14 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 70
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 71 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 121
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 122 GGPPPKASPSTAGETPSG 139
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 37.0 bits (84), Expect = 0.044
Identities = 31/130 (23%), Positives = 49/130 (37%), Gaps = 11/130 (8%)
Query: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEP----ETGSAVSA 66
+ GS + E P G R K + L+ K KGA P + G+ S
Sbjct: 274 EEGSESEEEAPAGT----RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 67 AQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGG 123
+ P + S + E+ PA ++ + +A + Q + A + RKG
Sbjct: 330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 389
Query: 124 PPPKASPSTA 133
PP K P+ A
Sbjct: 390 PPGKTGPAVA 399
Score = 29.3 bits (64), Expect = 9.2
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 19 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 68
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1420 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1474
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 38.1 bits (87), Expect = 0.020
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 14 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 70
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 71 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 121
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 122 GGPPPKASPSTAGETPSG 139
G P ST G P G
Sbjct: 424 GKSPQVKPASTMGMGPLG 441
Score = 33.1 bits (74), Expect = 0.63
Identities = 27/111 (24%), Positives = 44/111 (39%), Gaps = 8/111 (7%)
Query: 30 EMTKEEKLQLRKEKKQQKKKRKEEKGAEP----ETGSAVSAAQCQGPTRELPESGIQLGT 85
E+ EK+ L+ K KGA P + G+ S + P + S +
Sbjct: 213 EVKASEKI-LQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 271
Query: 86 PREKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGGPPPKASPSTA 133
E+ PA ++ + +A + Q + A + RKG PP K P+ A
Sbjct: 272 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Score = 29.3 bits (64), Expect = 9.2
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 19 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 68
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1343 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1397
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 38.1 bits (87), Expect = 0.020
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 14 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 70
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 71 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 121
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 122 GGPPPKASPSTAGETPSG 139
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 37.0 bits (84), Expect = 0.044
Identities = 31/130 (23%), Positives = 49/130 (37%), Gaps = 11/130 (8%)
Query: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEP----ETGSAVSA 66
+ GS + E P G R K + L+ K KGA P + G+ S
Sbjct: 274 EEGSESEEEAPAGT----RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 67 AQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGG 123
+ P + S + E+ PA ++ + +A + Q + A + RKG
Sbjct: 330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 389
Query: 124 PPPKASPSTA 133
PP K P+ A
Sbjct: 390 PPGKTGPAVA 399
Score = 29.3 bits (64), Expect = 9.2
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 19 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 68
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1382 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1436
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 38.1 bits (87), Expect = 0.020
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 14 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 70
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 71 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 121
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 122 GGPPPKASPSTAGETPSG 139
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 37.0 bits (84), Expect = 0.044
Identities = 31/130 (23%), Positives = 49/130 (37%), Gaps = 11/130 (8%)
Query: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEP----ETGSAVSA 66
+ GS + E P G R K + L+ K KGA P + G+ S
Sbjct: 274 EEGSESEEEAPAGT----RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Query: 67 AQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGG 123
+ P + S + E+ PA ++ + +A + Q + A + RKG
Sbjct: 330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 389
Query: 124 PPPKASPSTA 133
PP K P+ A
Sbjct: 390 PPGKTGPAVA 399
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 37.7 bits (86), Expect = 0.026
Identities = 45/200 (22%), Positives = 72/200 (36%), Gaps = 24/200 (12%)
Query: 22 PGP-GAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESG 80
PGP G G ++ EE + R + + K+ GA +T R +G
Sbjct: 117 PGPLGQKGLRISAEETVA-RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 175
Query: 81 IQLGTPREKVPAGRSKAELRAERRAKQEA------ERALKQARKGEQGG----------- 123
++G PR P+ R + R++ A E + R+ GG
Sbjct: 176 TEVGLPRP-APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 234
Query: 124 --PPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSH 181
P +SP+ +G + G R P +P + ++ P Q P RKD + S
Sbjct: 235 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP--QVTPPRKDAAPALGPLSS 292
Query: 182 LPQYSRQNSLTQFMSIPSSV 201
P + S S P S+
Sbjct: 293 SPLATPSPSAPPSPSAPPSL 312
>gi|21361517 UBX domain protein 1 [Homo sapiens]
Length = 312
Score = 37.7 bits (86), Expect = 0.026
Identities = 40/146 (27%), Positives = 65/146 (44%), Gaps = 16/146 (10%)
Query: 13 GSGMKA-ELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET-----GSAVSA 66
GSG A E P R+ + L+L +K++++++R+E + E E G +SA
Sbjct: 74 GSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSA 133
Query: 67 AQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPP 126
A+ + E+ + + + + A R + + ER +AERA K G G PP
Sbjct: 134 ARQRLQEDEMRRAAEERRREKAEELAARQRVREKIER---DKAERAKKYG--GSVGSQPP 188
Query: 127 KASPSTAGETPSGVKRLP----EYPQ 148
+P G PS + P EY Q
Sbjct: 189 PVAPE-PGPVPSSPSQEPPTKREYDQ 213
>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
sapiens]
Length = 1158
Score = 37.4 bits (85), Expect = 0.034
Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 41 KEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELR 100
++ K + KK K++KG + S + + +E P + P+EK P K + +
Sbjct: 88 EKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATK--KPKEKPPKATKKPKEK 145
Query: 101 AERRAKQEAERALKQARKGEQGGPPPKASPSTAGETP 137
+ K+ E+ K +K G PP +PS E P
Sbjct: 146 PPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWP 182
>gi|224591430 Ly1 antibody reactive homolog [Homo sapiens]
Length = 379
Score = 37.4 bits (85), Expect = 0.034
Identities = 35/159 (22%), Positives = 75/159 (47%), Gaps = 14/159 (8%)
Query: 26 AVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGT 85
AV ++ ++ + RKE++Q+K+KR E+K + E S Q ++ E+ ++ G
Sbjct: 177 AVEQQGEVKKNKRERKEERQKKRKR-EKKELKLENHQENSRNQKPKKRKKGQEADLEAG- 234
Query: 86 PREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPE 145
E+VP A R++++ +++ + ++AR G G + ++ +LPE
Sbjct: 235 -GEEVPEANGSAGKRSKKKKQRKDSASEEEARVG--AGKRKRRHSEVETDSKKKKMKLPE 291
Query: 146 YPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQ 184
+P+ + PE + P + + K ++ + L Q
Sbjct: 292 HPEGGE---------PEDDEAPAKGKFNWKGTIKAILKQ 321
Score = 32.3 bits (72), Expect = 1.1
Identities = 28/132 (21%), Positives = 53/132 (40%), Gaps = 4/132 (3%)
Query: 33 KEEKLQLRKEKKQQKKKRKEEKGAEPET---GSAVSAAQCQGPTRELPESGIQLGTPREK 89
KE KL+ +E + +K +K +KG E + G V A R + + E+
Sbjct: 204 KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEE 263
Query: 90 VPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSG-VKRLPEYPQ 148
G K + R ++ +K E G P +P+ G +K + +
Sbjct: 264 ARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAP 323
Query: 149 VDDLLLRRLVKK 160
+++ +++L KK
Sbjct: 324 DNEITIKKLRKK 335
>gi|8923398 Ly1 antibody reactive homolog [Homo sapiens]
Length = 379
Score = 37.4 bits (85), Expect = 0.034
Identities = 35/159 (22%), Positives = 75/159 (47%), Gaps = 14/159 (8%)
Query: 26 AVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGT 85
AV ++ ++ + RKE++Q+K+KR E+K + E S Q ++ E+ ++ G
Sbjct: 177 AVEQQGEVKKNKRERKEERQKKRKR-EKKELKLENHQENSRNQKPKKRKKGQEADLEAG- 234
Query: 86 PREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPE 145
E+VP A R++++ +++ + ++AR G G + ++ +LPE
Sbjct: 235 -GEEVPEANGSAGKRSKKKKQRKDSASEEEARVG--AGKRKRRHSEVETDSKKKKMKLPE 291
Query: 146 YPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQ 184
+P+ + PE + P + + K ++ + L Q
Sbjct: 292 HPEGGE---------PEDDEAPAKGKFNWKGTIKAILKQ 321
Score = 32.3 bits (72), Expect = 1.1
Identities = 28/132 (21%), Positives = 53/132 (40%), Gaps = 4/132 (3%)
Query: 33 KEEKLQLRKEKKQQKKKRKEEKGAEPET---GSAVSAAQCQGPTRELPESGIQLGTPREK 89
KE KL+ +E + +K +K +KG E + G V A R + + E+
Sbjct: 204 KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEE 263
Query: 90 VPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSG-VKRLPEYPQ 148
G K + R ++ +K E G P +P+ G +K + +
Sbjct: 264 ARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAP 323
Query: 149 VDDLLLRRLVKK 160
+++ +++L KK
Sbjct: 324 DNEITIKKLRKK 335
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 37.4 bits (85), Expect = 0.034
Identities = 27/104 (25%), Positives = 48/104 (46%), Gaps = 12/104 (11%)
Query: 29 REMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPRE 88
++ K+ + RK KK++KK++K +K A E+ + AQ Q R P E
Sbjct: 228 KKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVR-----------PEE 276
Query: 89 KVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPST 132
P ++ +R E ER ++ R+ E+ PP + P++
Sbjct: 277 IPPIPENRFLMRKSPPKADEKERKNRE-RERERECNPPNSQPAS 319
Score = 30.4 bits (67), Expect = 4.1
Identities = 27/156 (17%), Positives = 65/156 (41%), Gaps = 12/156 (7%)
Query: 17 KAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTREL 76
K + P A R ++ E + K KK++KK+ K + + + S++ Q +
Sbjct: 158 KTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSD-- 215
Query: 77 PESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGET 136
+ E +SK + R+ ++ ++ K+ +K ++ + + +
Sbjct: 216 -------SSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQP 268
Query: 137 PSGVK--RLPEYPQVDDLLLRRLVKKPERQQVPTRK 170
S V+ +P P+ + L+R+ K + ++ R+
Sbjct: 269 QSTVRPEEIPPIPE-NRFLMRKSPPKADEKERKNRE 303
>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
sapiens]
Length = 2524
Score = 37.0 bits (84), Expect = 0.044
Identities = 29/125 (23%), Positives = 47/125 (37%), Gaps = 9/125 (7%)
Query: 30 EMTKEEKLQLRKEKKQQKKKRKEEKGAEPETG-------SAVSAAQCQGPTRELPESGIQ 82
E+ ++ KL++ KE+ ++KK+K A E + A+ G E+ E
Sbjct: 664 EILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEA 723
Query: 83 LGTPREKVPAGRSKAELRAERRAKQEA--ERALKQARKGEQGGPPPKASPSTAGETPSGV 140
L +VP G + E+ + A+ Q GP P A+ G P
Sbjct: 724 LHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPP 783
Query: 141 KRLPE 145
PE
Sbjct: 784 TPPPE 788
Score = 32.0 bits (71), Expect = 1.4
Identities = 38/158 (24%), Positives = 58/158 (36%), Gaps = 19/158 (12%)
Query: 10 EDSGSGMKAELPPGPGAVGREMTKEEKLQLR------KEKKQQKKKRKEE------KGAE 57
E +G+ PP P A + KEEK + +E ++QK EE K E
Sbjct: 801 EATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEE 860
Query: 58 PETGSAVSAAQ---CQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAER--- 111
P A+ +G E E+ + EK G +A A Q+++
Sbjct: 861 PVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSAT 920
Query: 112 -ALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQ 148
+ + + E G SP + TP+G R PQ
Sbjct: 921 CSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQ 958
>gi|116805342 human immunodeficiency virus type I enhancer binding
protein 1 [Homo sapiens]
Length = 2718
Score = 37.0 bits (84), Expect = 0.044
Identities = 34/96 (35%), Positives = 43/96 (44%), Gaps = 21/96 (21%)
Query: 125 PPKA---SPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQV---PTRKDYGSKVSL 178
PP A SP TA PS P+ PQ ++QQ+ PT L
Sbjct: 2334 PPAAAEHSPQTAAGMPSVASPHPD-PQ------------EQKQQITLQPTPGLPSPHTHL 2380
Query: 179 FSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYS 214
FSHLP +S+Q S T + +P IH +V GL YS
Sbjct: 2381 FSHLPLHSQQQSRTPYNMVPVGGIH--VVPAGLTYS 2414
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 36.6 bits (83), Expect = 0.057
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 1/94 (1%)
Query: 28 GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPR 87
G+E ++E+ + + K++++KK + EK E + Q E E + R
Sbjct: 130 GKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKR 189
Query: 88 EKVPAGRSKAELRAERRAKQEAERALKQARKGEQ 121
E+ R K R ERR +++ ER K+ RK E+
Sbjct: 190 ERNRKERKKERERKERRERKK-ERKKKEERKKER 222
Score = 36.2 bits (82), Expect = 0.075
Identities = 33/138 (23%), Positives = 63/138 (45%), Gaps = 7/138 (5%)
Query: 33 KEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPA 92
K+E+ + K K++++K+RK E+G + + G + + R E+ + G +EK
Sbjct: 60 KKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKEN--KEGEEKEK--- 114
Query: 93 GRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDL 152
+ K + R +K+ ER K+ RK E+ + E ++ E QV +
Sbjct: 115 RKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEK 174
Query: 153 LLRRLVKKPERQQVPTRK 170
R K+ ER++ R+
Sbjct: 175 EEER--KEKERKERKKRE 190
Score = 33.5 bits (75), Expect = 0.49
Identities = 27/148 (18%), Positives = 63/148 (42%), Gaps = 3/148 (2%)
Query: 24 PGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQL 83
PG +E +++ RKE K++++ ++++ E E + + + + G +
Sbjct: 32 PGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERK 91
Query: 84 GTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRL 143
RE+ R K E + K++ + ++ R ++G + E ++
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK 151
Query: 144 PEYPQVDDLLLRRLVKKPERQQVPTRKD 171
E + + R+ KK ER+QV +++
Sbjct: 152 EEREKERE---RKERKKRERKQVGEKEE 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,058,786
Number of Sequences: 37866
Number of extensions: 1029932
Number of successful extensions: 9986
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 384
Number of HSP's that attempted gapping in prelim test: 8129
Number of HSP's gapped (non-prelim): 1690
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.