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Search of human proteins with 7662352
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
(469 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 916 0.0
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 869 0.0
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 744 0.0
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 485 e-137
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 463 e-130
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 463 e-130
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 463 e-130
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 431 e-121
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 120 3e-27
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 118 1e-26
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 113 4e-25
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 108 1e-23
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 108 1e-23
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 107 2e-23
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 70 4e-12
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 62 1e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 1e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 61 2e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 60 3e-09
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 59 7e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 59 7e-09
gi|40538728 pleckstrin homology domain containing, family M (wit... 58 2e-08
gi|55770834 centromere protein F [Homo sapiens] 58 2e-08
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 58 2e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 57 5e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 56 6e-08
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 56 8e-08
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 56 8e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens] 56 8e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 55 1e-07
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 916 bits (2367), Expect = 0.0
Identities = 469/469 (100%), Positives = 469/469 (100%)
Query: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED
Sbjct: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
Query: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
Query: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
Query: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
Query: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
Query: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH 469
QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH
Sbjct: 421 QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH 469
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 869 bits (2246), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED
Sbjct: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
Query: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
Query: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
Query: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
Query: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
Query: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
QKSELNSRLEEKTNQMAATIKQLEQ
Sbjct: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
Score = 32.0 bits (71), Expect = 1.2
Identities = 40/193 (20%), Positives = 88/193 (45%), Gaps = 7/193 (3%)
Query: 213 VGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNR 272
+ + +++ + C K + L S +D LK + K D + + + +EE
Sbjct: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
Query: 273 HLNATVNNLQAKVDALEKS--NTKLTEELAVAN--NRIITLQEEMERVKEESSYILESNR 328
+ AT+ L+ ++ E+S + +L L + ++I +LQ E+E + + + LE
Sbjct: 435 QMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQ-LELEL 493
Query: 329 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 388
K K+ R +++ R K E+++ K E + +++ +E + ++ + E+
Sbjct: 494 KQEKERRLQNDRSI-PGRGSQKSESKMD-GKHKMQEENVKLKKPLEESHRLQPHPMDEQD 551
Query: 389 DALVSLRQQLDDL 401
L+S + QL L
Sbjct: 552 QLLLSEKPQLCQL 564
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 744 bits (1920), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 121 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180
Query: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 240
Query: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 241 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 300
Query: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 301 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 360
Query: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 361 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
QKSELNSRLEEKTNQMAATIKQLEQ
Sbjct: 481 QKSELNSRLEEKTNQMAATIKQLEQ 505
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 485 bits (1249), Expect = e-137
Identities = 251/394 (63%), Positives = 313/394 (79%), Gaps = 14/394 (3%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 43 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 102
Query: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
NK+ WGPLELVEKL PEA EI ASV+DLPGLKTP+GR RAWLRLALMQKK+++Y++ LI
Sbjct: 103 NKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLII 162
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
+++LLSEFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 163 QRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 222
Query: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 223 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 282
Query: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 283 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 342
Query: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
Query: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQ
Sbjct: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 436
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/206 (24%), Positives = 92/206 (44%), Gaps = 35/206 (16%)
Query: 232 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 291
+V I+ MY K S G + +I A L++K + A + L+ ++ EK+
Sbjct: 391 EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKT------NKITAAMRQLEQRLQQAEKA 444
Query: 292 NTKLTEE----LAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALS---E 344
+ +E L ++ +LQ+++ + KE+ LE++ K K+ R + L +
Sbjct: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQ-KEKQLVQLETDLKIEKEWRQTLQEDLQKEKD 503
Query: 345 ARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 404
A HL+ ETQ + ++KE ++++ E + L+K E++ AL
Sbjct: 504 ALSHLRNETQQIISLKKEF---LNLQDENQ----QLKKIYHEQEQAL------------- 543
Query: 405 KHELAFKLQSSDLGVKQKSELNSRLE 430
EL KL S L ++ E N L+
Sbjct: 544 -QELGNKLSESKLKIEDIKEANKALQ 568
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 463 bits (1191), Expect = e-130
Identities = 237/395 (60%), Positives = 308/395 (77%), Gaps = 14/395 (3%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 395
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 463 bits (1191), Expect = e-130
Identities = 237/395 (60%), Positives = 308/395 (77%), Gaps = 14/395 (3%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 395
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 463 bits (1191), Expect = e-130
Identities = 237/395 (60%), Positives = 308/395 (77%), Gaps = 14/395 (3%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 109 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 168
Query: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 169 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 228
Query: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 229 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 288
Query: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 289 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 348
Query: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 349 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
Query: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+
Sbjct: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 503
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 431 bits (1107), Expect = e-121
Identities = 233/406 (57%), Positives = 291/406 (71%), Gaps = 48/406 (11%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
Query: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
NK+ WGPLELVEKL PEA EI ASV+DLPGL
Sbjct: 68 NKTIWGPLELVEKLYPEAEEIGASVRDLPGL----------------------------- 98
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
+EFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 99 -----NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 153
Query: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 154 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 213
Query: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 214 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 273
Query: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 274 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
Query: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTL 457
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQS+ DL+ Q +T+
Sbjct: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQSDNDLLTQTRTI 379
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 120 bits (300), Expect = 3e-27
Identities = 101/362 (27%), Positives = 170/362 (46%), Gaps = 46/362 (12%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+ + + S+K LI+ + T+D F ++E L H LK + T+ G
Sbjct: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
Query: 126 N--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKAL 183
+SFW + + + V + S++++ + + +GRAW+R+ALM+K LSEY+
Sbjct: 88 ESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTA 145
Query: 184 INKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYL 242
+ + FYE A+++ EE ++AG+L+GLN ID +FC+KGE LD S VID++ YL
Sbjct: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
Query: 243 KDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA 302
K SS D EEL T+ + ++ E +
Sbjct: 206 KYIQSSDSISSD------------EEELR-----TLGSSGSESSTPENVGPPFLMDENSW 248
Query: 303 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 362
N+ ++++ + E+ Y+ E R ++++ +E + ++ E++ L +EKE
Sbjct: 249 FNKCKRVKQKYQLTLEQKGYLEELLRL--RENQLSESVSQNKILLQRIEDSDLAHKLEKE 306
Query: 363 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQK 422
LE + E QD L S Q LD L A E++ S D G Q+
Sbjct: 307 ----------------QLEYIIVELQDQLKSY-QSLDQLSA---EVSLSQTSLDPGQSQE 346
Query: 423 SE 424
+
Sbjct: 347 GD 348
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 118 bits (295), Expect = 1e-26
Identities = 68/192 (35%), Positives = 108/192 (56%), Gaps = 7/192 (3%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+ + + S+K LI+ + T+D F ++E L H LK + T+ G
Sbjct: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
Query: 126 N--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKAL 183
+SFW + + + V + S++++ + + +GRAW+R+ALM+K LSEY+
Sbjct: 88 ESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTA 145
Query: 184 INKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYL 242
+ + FYE A+++ EE ++AG+L+GLN ID +FC+KGE LD S VID++ YL
Sbjct: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
Query: 243 KDGNSSKGTEGD 254
K SS D
Sbjct: 206 KYIQSSDSISSD 217
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 113 bits (282), Expect = 4e-25
Identities = 81/298 (27%), Positives = 136/298 (45%), Gaps = 57/298 (19%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
+A ER NL+ + + S+K L+E +D F ++E L H K ++
Sbjct: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFS 81
Query: 125 QN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKA 182
+ + FW + L VP +S++++ + T +GRAW+R+ALM+K++SEY+
Sbjct: 82 SDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITT 139
Query: 183 LINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-VIDFSMY 241
+ FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + VID++ Y
Sbjct: 140 ALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPY 199
Query: 242 LK--------------------------------------DGNSSKGTEGDGQITAILDQ 263
LK D SK + + + + Q
Sbjct: 200 LKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQ 259
Query: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITLQEEM 313
K Y+EEL R + + +L+A+ L+ EE A N R I+ LQE++
Sbjct: 260 KGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILELQEQL 313
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 108 bits (270), Expect = 1e-23
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 64/304 (21%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK---- 120
+A ER NL+ + + S+K L+E +D F ++E L H KA
Sbjct: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAPAGP 81
Query: 121 ----TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKL 176
+ GQ + FW + L VP +S++++ + T +GRAW+R+ALM+K++
Sbjct: 82 VSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRM 138
Query: 177 SEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-V 235
SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + V
Sbjct: 139 SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVV 198
Query: 236 IDFSMYLK--------------------------------------DGNSSKGTEGDGQI 257
ID++ YLK D SK + + +
Sbjct: 199 IDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF 258
Query: 258 TAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITL 309
+ QK Y+EEL R + + +L+A+ L+ EE A N R I+ L
Sbjct: 259 RIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILEL 314
Query: 310 QEEM 313
QE++
Sbjct: 315 QEQL 318
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 108 bits (270), Expect = 1e-23
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 64/304 (21%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK---- 120
+A ER NL+ + + S+K L+E +D F ++E L H KA
Sbjct: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAPAGP 81
Query: 121 ----TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKL 176
+ GQ + FW + L VP +S++++ + T +GRAW+R+ALM+K++
Sbjct: 82 VSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRM 138
Query: 177 SEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-V 235
SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + V
Sbjct: 139 SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVV 198
Query: 236 IDFSMYLK--------------------------------------DGNSSKGTEGDGQI 257
ID++ YLK D SK + + +
Sbjct: 199 IDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF 258
Query: 258 TAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITL 309
+ QK Y+EEL R + + +L+A+ L+ EE A N R I+ L
Sbjct: 259 RIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILEL 314
Query: 310 QEEM 313
QE++
Sbjct: 315 QEQL 318
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 107 bits (267), Expect = 2e-23
Identities = 68/209 (32%), Positives = 108/209 (51%), Gaps = 24/209 (11%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-------- 117
A ER NL+ + + S+K LI+ + T+D F ++E L H LK
Sbjct: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKEISQSCRW 87
Query: 118 ---------AKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAW 166
+ T+ G +SFW + + + V + S++++ + + +GRAW
Sbjct: 88 LAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAW 145
Query: 167 LRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG 226
+R+ALM+K LSEY+ + + FYE A+++ EE ++AG+L+GLN ID +FC+KG
Sbjct: 146 IRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKG 205
Query: 227 EDLD-SQVGVIDFSMYLKDGNSSKGTEGD 254
E LD S VID++ YLK SS D
Sbjct: 206 EGLDGSFPAVIDYTPYLKYIQSSDSISSD 234
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 70.1 bits (170), Expect = 4e-12
Identities = 78/336 (23%), Positives = 155/336 (46%), Gaps = 18/336 (5%)
Query: 91 GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV 150
G + D L +F +E+ L+ K K T LG K +W V A + V
Sbjct: 32 GEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFV 91
Query: 151 KDLPGLKTPVGRGRAWLRLALMQKKLSEYM-KALINKKELLSEFYEPNALMMEEEGAIIA 209
K + L+T +G+GRA++R +L+ ++L++ + + +N K +Y + + + + I
Sbjct: 92 KSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIV 151
Query: 210 GLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSS---KGTEGDGQITAILDQKNY 266
G L L + + +G DLD+ L G+S+ K +++++
Sbjct: 152 GQLYELTEVQFDLASRGFDLDAAWPTF-ARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQ 210
Query: 267 VEEL--NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYIL 324
+E+ N LN+ +NN +ALE + ++ EL R L+E M+++ E+ +
Sbjct: 211 TQEMVSNFDLNSPLNN-----EALEGFD-EMRLELDQLEVREKQLRERMQQLDRENQELR 264
Query: 325 ESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR---QEMELAMKMLE 381
+ + +Q +T + + A +++ T L +++K+ E+ + + +E++ ++ LE
Sbjct: 265 AAVSQQGEQLQTERERGRTAAEDNVR-LTCLVAELQKQWEVTQATQNTVKELQTCLQGLE 323
Query: 382 KDVCEK-QDALVSLRQQLDDLRALKHELAFKLQSSD 416
EK +D +LR+ L+ L EL S D
Sbjct: 324 LGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLD 359
Score = 43.1 bits (100), Expect = 5e-04
Identities = 51/198 (25%), Positives = 86/198 (43%), Gaps = 29/198 (14%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEE---LAVANNRIITLQEEMERVKE 318
D + L L L+A D+L+K N L LA+A + T + R +
Sbjct: 332 DYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEP 391
Query: 319 ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMK 378
S D E Q L E + L+ E R VE+ + ++ ++
Sbjct: 392 IPS------------DAAQEMQELGEKLQALERE---RTKVEE-------VNRQQSAQLE 429
Query: 379 MLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSEL---NSRLEEKTNQ 435
L K++ K+DA SL + + ++ L+ EL+ K Q +D ++ EL S EE+ +
Sbjct: 430 QLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAE 489
Query: 436 MAATIKQLEQSEKDLVKQ 453
+ KQ +Q EK+L++Q
Sbjct: 490 LRREKKQ-QQEEKELLEQ 506
Score = 41.2 bits (95), Expect = 0.002
Identities = 51/228 (22%), Positives = 92/228 (40%), Gaps = 27/228 (11%)
Query: 259 AILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKE 318
A L+ E+L+R N L +V AL ++ E LA A + +E R +E
Sbjct: 887 AQLEHAELQEQLHR-ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRERE 945
Query: 319 ESSYILESNRKGPKQDRTAEGQALSEARKHLKE----ETQLRLDVEKELEMQISMRQEME 374
LE G +Q++ + + L A+ + QL ++ +Q + QE+
Sbjct: 946 G----LERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELN 1001
Query: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS------------DLGVKQK 422
L ++ + Q L + ++ LR E +LQ++ D+G K
Sbjct: 1002 TLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLS 1061
Query: 423 ------SELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+E + + K + AA + LE+++K+L K + NKL
Sbjct: 1062 CTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKL 1109
Score = 38.5 bits (88), Expect = 0.013
Identities = 48/216 (22%), Positives = 99/216 (45%), Gaps = 16/216 (7%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA---NNRII----T 308
Q+ + + +EE + L ++L +V LE+ EL VA N ++ +
Sbjct: 521 QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSS 580
Query: 309 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQIS 368
LQE + +EE + E+ K ++ + L +A + L++E Q + + LE ++
Sbjct: 581 LQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQ 640
Query: 369 MRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV-KQKSELNS 427
Q A++ E + Q +L SL + +R L ++++S L V K K + +
Sbjct: 641 ALQADYQALQQRESAI---QGSLASLEAEQASIR----HLGDQMEASLLAVRKAKEAMKA 693
Query: 428 RLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANK 463
++ EK + + + +Q ++ V+Q + L A ++
Sbjct: 694 QMAEKEAILQSKEGECQQLREE-VEQCQQLAEARHR 728
Score = 38.1 bits (87), Expect = 0.017
Identities = 44/213 (20%), Positives = 90/213 (42%), Gaps = 21/213 (9%)
Query: 272 RHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI-------- 323
+ L A V +LQAK+ A K+ +L++A + + ++++KE++ +
Sbjct: 786 QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
Query: 324 ---------LESNRKGPKQDRTAEGQALSEARKHLK---EETQL-RLDVEKELEMQISMR 370
L+ R Q R E +AL E K EE QL +++++L +
Sbjct: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
E+ + + L + ++AL Q+L D + L+ G++Q+ E
Sbjct: 906 AELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965
Query: 431 EKTNQMAATIKQLEQSEKDLVKQAKTLNSAANK 463
+ A ++ L+ ++A++L AA++
Sbjct: 966 KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQ 998
Score = 34.3 bits (77), Expect = 0.25
Identities = 36/150 (24%), Positives = 69/150 (46%), Gaps = 13/150 (8%)
Query: 256 QITAILDQKNYVEELNR----HLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQE 311
++ A+ ++ VEE+NR L V LQ K DA S +L +E+A LQE
Sbjct: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDA-RASLERLVKEMA-------PLQE 457
Query: 312 EMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ 371
E+ +E+ + ++ + E + L+E R+ K++ + + +E+E+ Q
Sbjct: 458 ELSGKGQEADQLWRRLQELLAHTSSWE-EELAELRREKKQQQEEKELLEQEVRSLTRQLQ 516
Query: 372 EMELAMKMLEKDVCEKQDALVSLRQQLDDL 401
+E + + + V + ++ L Q D L
Sbjct: 517 FLETQLAQVSQHVSDLEEQKKQLIQDKDHL 546
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 61.6 bits (148), Expect = 1e-09
Identities = 53/206 (25%), Positives = 103/206 (50%), Gaps = 22/206 (10%)
Query: 268 EELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRIITLQEEMERVKE-- 318
EE+N L A L+ + +D LE + K+ +E N++ L EEM + E
Sbjct: 930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 319 -----ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 373
E + E++++ + E + + + +K E Q+ D+E LE + +R ++
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD-DLEGSLEQEKKVRMDL 1048
Query: 374 ELAMKMLEKDVCEKQDALVSL---RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
E A + LE D+ Q++++ L +QQLD+ K F+L + + ++ + L S+L+
Sbjct: 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD---FELNALNARIEDEQALGSQLQ 1105
Query: 431 EKTNQMAATIKQLEQS-EKDLVKQAK 455
+K ++ A I++LE+ E + +AK
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAK 1131
Score = 57.4 bits (137), Expect = 3e-08
Identities = 52/222 (23%), Positives = 111/222 (50%), Gaps = 29/222 (13%)
Query: 252 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 306
EGD ++T +I+D +N ++L+ L +N L A+++ + ++L ++L RI
Sbjct: 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115
Query: 307 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQ 366
L+EE+E + + + + + D + E + +SE + T +++++ K+ E +
Sbjct: 1116 EELEEELEAERTARAKV-----EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 367 I-SMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ 421
MR+++E A E + D++ L +Q+D+L+ +K +L K+
Sbjct: 1171 FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE----------KE 1220
Query: 422 KSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANK 463
KSE L++ T+ M +Q+ +++ +L K +TL N+
Sbjct: 1221 KSEFKLELDDVTSNM----EQIIKAKANLEKMCRTLEDQMNE 1258
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/228 (20%), Positives = 100/228 (43%), Gaps = 18/228 (7%)
Query: 248 SKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRII 307
SK E + + Q+ ++ N L+ ++ +A + L + T++L ++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL- 1319
Query: 308 TLQEEMERVKEESSYILESNRKGP---KQDRTAEGQALSEARKHLK----EETQLRLDVE 360
EE + K ++ L+S R ++ E +A +E ++ L E Q R E
Sbjct: 1320 ---EEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
+ I +E+E A K L + + E ++A+ ++ + L KH L +++ + V+
Sbjct: 1377 TDA---IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 421 QKSELNSRLEEKTNQ----MAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+ + + L++K +A ++ E+S+ +L K S + +L
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/197 (22%), Positives = 91/197 (46%), Gaps = 18/197 (9%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI-------ITLQEEMERVKEE 319
VE N L A + L+A V+ E+S +EL + R+ +L + +++ +
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAD 1733
Query: 320 SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQI---SMRQEMELA 376
S + + ++ R AE +A+K + + + +++KE + M++ ME
Sbjct: 1734 LSQLQTEVEEAVQECRNAE----EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1789
Query: 377 MKMLEKDVCE-KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQ 435
+K L+ + E +Q AL ++QL L A EL +L++ K+ +E + + +
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQ---KRNAESVKGMRKSERR 1846
Query: 436 MAATIKQLEQSEKDLVK 452
+ Q E+ K+L++
Sbjct: 1847 IKELTYQTEEDRKNLLR 1863
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/185 (22%), Positives = 80/185 (43%), Gaps = 13/185 (7%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E++ + L A LQ+ ALE++ L E +I+ Q E ++K E L
Sbjct: 1526 LEKVRKQLEAEKMELQS---ALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1578
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQEMELAMKMLEKD 383
+ +Q + + + + L ET+ R L V+K++E ++ EME+ + +
Sbjct: 1579 KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN---EMEIQLSHANRM 1635
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 443
E Q + SL+ L D + + + N+ L+ + ++ A ++Q
Sbjct: 1636 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1695
Query: 444 EQSEK 448
E+S K
Sbjct: 1696 ERSRK 1700
Score = 36.2 bits (82), Expect = 0.066
Identities = 34/136 (25%), Positives = 62/136 (45%), Gaps = 9/136 (6%)
Query: 334 DRTAEGQALSEARKHLKEETQLRLDVEKELEMQ-ISMRQEMELAMKMLEKDVCEKQDALV 392
+R E ++ E LKE + KELE + +S+ QE L+ V +QD L
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKN----DLQLQVQAEQDNLA 899
Query: 393 SLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQS----EK 448
++ D L K +L K++ + ++ + E+N+ L K ++ +L++ E
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLEL 959
Query: 449 DLVKQAKTLNSAANKL 464
L K K ++ NK+
Sbjct: 960 TLAKVEKEKHATENKV 975
Score = 34.3 bits (77), Expect = 0.25
Identities = 34/183 (18%), Positives = 86/183 (46%), Gaps = 8/183 (4%)
Query: 282 QAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQA 341
+ ++ ++++ T+L E L + R L+E+M + +E + + + +QD A+ +
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL--QLQVQAEQDNLADAEE 903
Query: 342 LSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL 401
+ + +K + QL V KE+ ++ +EM + ++ + +D L++ +DDL
Sbjct: 904 RCD--QLIKNKIQLEAKV-KEMNERLEDEEEMNAELTAKKRKL---EDECSELKRDIDDL 957
Query: 402 RALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAA 461
++ + +++ VK +E + L+E ++ K L+++ + + +
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 462 NKL 464
N L
Sbjct: 1018 NTL 1020
Score = 34.3 bits (77), Expect = 0.25
Identities = 41/188 (21%), Positives = 85/188 (45%), Gaps = 14/188 (7%)
Query: 278 VNNLQAKVDALEKSNTKLT---EELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD 334
V + AK +LEK+ +L E+L V R +++ + IL ++ ++
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Query: 335 RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVS- 393
++ + EAR E +L+ E+ LE + ++E K L++++ + + L S
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN----KNLQEEISDLTEQLGSS 1519
Query: 394 ------LRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSE 447
L + L A K EL L+ ++ ++ + R + + NQ+ A I++ +
Sbjct: 1520 GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK 1579
Query: 448 KDLVKQAK 455
+ ++QAK
Sbjct: 1580 DEEMEQAK 1587
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 61.6 bits (148), Expect = 1e-09
Identities = 71/312 (22%), Positives = 148/312 (47%), Gaps = 43/312 (13%)
Query: 174 KKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLV------GLNVIDANFCMKGE 227
K LSE M AL +E +S+ + + E + L V GL I+A + +
Sbjct: 980 KNLSEEMTAL---EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD 1036
Query: 228 DLDSQVGVIDFSMYLKDG--NSSKGTEGDGQIT--AILDQKN---YVEELNRHLNATVNN 280
DL+ G ++ L+ + + EGD +++ +I+D +N +EE + ++
Sbjct: 1037 DLE---GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 281 LQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQ 340
LQAK+D + + + +++ RI L+EE+ E+ + L + + + D E +
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEI-----EAEHTLRAKIEKQRSDLARELE 1148
Query: 341 ALSEARKHLKEETQLRLDVEKELEMQI-SMRQEMELAMKMLEKDVC----EKQDALVSLR 395
+SE + T ++++ K+ E + MR+++E A E ++ D++ L
Sbjct: 1149 EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208
Query: 396 QQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAK 455
+Q+D+L+ +K +L K+KSEL +++ MA+ I+ L +S+ ++ + +
Sbjct: 1209 EQIDNLQRVKQKLE----------KEKSELKMEIDD----MASNIEALSKSKSNIERTCR 1254
Query: 456 TLNSAANKLIPK 467
T+ +++ K
Sbjct: 1255 TVEDQFSEIKAK 1266
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/205 (21%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 306
+ ++ + ++ EE+N L A NL+ K +D LE + TK+ +E N++
Sbjct: 920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV 979
Query: 307 ITLQEEMERVKEESSYI------LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
L EEM ++E S + L+ + D E ++ K + Q D+E
Sbjct: 980 KNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
LE + +R ++E A + LE D+ Q++++ L + + F+L +
Sbjct: 1040 GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID 1099
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
+ + + ++K ++ A I++LE+
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEE 1124
Score = 50.1 bits (118), Expect = 4e-06
Identities = 47/200 (23%), Positives = 91/200 (45%), Gaps = 23/200 (11%)
Query: 280 NLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEG 339
NL K+ L KS A A + T++E+ ER KEE + E+ RK ++ +
Sbjct: 835 NLFFKIKPLLKS--------AEAEKEMATMKEDFERTKEELARS-EARRKELEEKMVSLL 885
Query: 340 QALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ----------- 388
Q ++ + ++ ET+ +D E+ E I + +E +K L + + E++
Sbjct: 886 QEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 389 ---DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
D SL++ +DDL ++ + +++ VK SE + LEE +++ K L++
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
Query: 446 SEKDLVKQAKTLNSAANKLI 465
+ + + + N LI
Sbjct: 1006 AHQQTLDDLQVEEDKVNGLI 1025
Score = 43.1 bits (100), Expect = 5e-04
Identities = 52/231 (22%), Positives = 103/231 (44%), Gaps = 28/231 (12%)
Query: 229 LDSQVGVIDFSMYLKDGNSSKGTEGD-GQITAILDQKN-YVEELNRHLNATVNNL---QA 283
LD+++ + ++ LK K EGD ++ L N + E +HL L Q
Sbjct: 1605 LDAEIRSRNDALRLK-----KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQ-----DRT-- 336
+D +SN L E+LA+ R L EE+E +K + R ++ DR
Sbjct: 1660 HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQL 1719
Query: 337 --AEGQALSEARKHLKEE-TQLRLDVEKELEMQISMRQEMELAM---KMLEKDVCEKQDA 390
++ +L +K L+ + Q + +VE ++ + ++ + A+ M+ +++ ++QD
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 391 LVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQM 436
L + +L +L +L ++ G KQ +L +R+ E N++
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Score = 40.4 bits (93), Expect = 0.003
Identities = 38/188 (20%), Positives = 87/188 (46%), Gaps = 27/188 (14%)
Query: 282 QAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQA 341
QA+++A +K + L+ EL N + +++E ++ E+ + E +Q
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ-------- 1519
Query: 342 LSEARKHLKEETQLRLDVEKE-LEMQISMRQ-----------------EMELAMKMLEKD 383
++E K+L+E + + VE+E ++Q+++ + E+ L++
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRK 1579
Query: 384 VCEKQDALVSL-RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQ 442
V EK + + L R AL+ L +++S + ++ K ++ L E Q+ + +Q
Sbjct: 1580 VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQ 1639
Query: 443 LEQSEKDL 450
+ +++K L
Sbjct: 1640 MAETQKHL 1647
Score = 37.7 bits (86), Expect = 0.023
Identities = 49/222 (22%), Positives = 100/222 (45%), Gaps = 27/222 (12%)
Query: 256 QITAILDQKNYVEELNRHLNATV-NNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME 314
Q T++++ K +E A V N++Q +A EK+ +T+ +A EE++
Sbjct: 1723 QNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA--------EELK 1774
Query: 315 RVKEESSYILESNRKGPKQD--------RTAEGQALSEARKHLKEETQLRLDVEKELEMQ 366
+ ++ S++ LE +K +Q AE AL +K +++ ++E EL+++
Sbjct: 1775 KEQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVE 1833
Query: 367 ISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALK-HELAFKLQSSDLGVKQKSEL 425
E E+ V E ++ + + D L+ +L KLQ+ K+++E
Sbjct: 1834 QKRGAEALKGAHKYERKVKE-----MTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAE- 1887
Query: 426 NSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
EE+ N + ++++ ++ ++A S NKL K
Sbjct: 1888 --EAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/294 (23%), Positives = 128/294 (43%), Gaps = 28/294 (9%)
Query: 173 QKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQ 232
QK E K+ +KEL + L+ E+ + N++DA E+ Q
Sbjct: 858 QKTKDELAKSEAKRKELEEKLV---TLVQEKNDLQLQVQAESENLLDA------EERCDQ 908
Query: 233 VGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSN 292
+ F + K ++ E + +I A L K R L + L+ +D LE +
Sbjct: 909 LIKAKFQLEAKIKEVTERAEDEEEINAELTAKK------RKLEDECSELKKDIDDLELTL 962
Query: 293 TKLTEELAVANNRIITLQEEMERVKEESSYI------LESNRKGPKQDRTAEGQALSEAR 346
K+ +E N++ L EE+ + E + + L+ + D AE ++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 347 KHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL---RQQLDDLRA 403
K + Q D+E LE + +R ++E + LE D+ Q++++ L +QQLD+
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Query: 404 LKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQS-EKDLVKQAKT 456
K +LQS V+ + L + ++K ++ A I++LE+ E + +AKT
Sbjct: 1083 KKDFEYCQLQSK---VEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKT 1133
Score = 42.0 bits (97), Expect = 0.001
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 15/217 (6%)
Query: 259 AILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKE 318
A L + V L + +V L ++D L++ KL +E + I L ME V +
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 1241
Query: 319 ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMK 378
+ + + R Q A G+ E ++ L E T + ++ E +E E +
Sbjct: 1242 SKANLEKICRTLEDQLSEARGKN-EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 379 MLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS----DLGVKQ-------KSELNS 427
L + L++QL++ K+ LA LQSS DL +Q K+EL
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360
Query: 428 RLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
L + +++A + + E D +++ + L A KL
Sbjct: 1361 ALSKANSEVA---QWRTKYETDAIQRTEELEEAKKKL 1394
Score = 42.0 bits (97), Expect = 0.001
Identities = 51/231 (22%), Positives = 97/231 (41%), Gaps = 39/231 (16%)
Query: 260 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME-RVKE 318
I ++ +E+L R+ TV +Q+ +DA +S N I L+++ME + E
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQSALDAEVRS-----------RNEAIRLKKKMEGDLNE 1625
Query: 319 ESSYILESNRKGP---KQDRTAEGQALSEARKHLKEETQLRLDVEKEL------------ 363
+ +NR+ K R+ +GQ L + + HL + + + D++++L
Sbjct: 1626 IEIQLSHANRQAAETLKHLRSVQGQ-LKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 364 ---EMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
E++ ++ Q E A K+ E+++ + + + L Q L K +L L V+
Sbjct: 1685 EVEELRATLEQ-TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVE 1743
Query: 421 QKSELNSRLEEKTNQ-------MAATIKQLEQSEKDLVKQAKTLNSAANKL 464
S EEK + MA +K+ + + L + K L L
Sbjct: 1744 DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1794
Score = 38.9 bits (89), Expect = 0.010
Identities = 52/231 (22%), Positives = 99/231 (42%), Gaps = 29/231 (12%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEE------MER 315
+Q VE L A V L+A ++ E++ +EL +N R+ L + ++
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 316 VKEESSYILESNRKGPKQD-RTAEGQALSEARKHLKEETQLRLDVEKELEMQIS---MRQ 371
E L+S + +D R AE +A+K + + + +++KE + M++
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAE----EKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Query: 372 EMELAMKMLEKDVCE-KQDALVSLRQQLDDLRALKHELAFKLQSSDL----GVKQKSELN 426
+E +K L+ + E +Q AL ++Q+ L EL F+L+ VK +
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845
Query: 427 SRLEEKTNQ----------MAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
R++E T Q + + +L+ K +QA+ + AN + K
Sbjct: 1846 RRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTK 1896
Score = 37.7 bits (86), Expect = 0.023
Identities = 58/249 (23%), Positives = 106/249 (42%), Gaps = 32/249 (12%)
Query: 229 LDSQVGVIDFSMYLKDGNSSKGTEGD-GQITAILDQKN-YVEELNRHLNATVNNL---QA 283
LD++V + ++ LK K EGD +I L N E +HL + L Q
Sbjct: 1602 LDAEVRSRNEAIRLK-----KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERV-----------KEESSYILESNRKGPK 332
+D + L E+LA+ R LQ E+E + K +L+SN +
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER--V 1714
Query: 333 QDRTAEGQALSEARKHLKEE-TQLRLDVEKELEMQISMRQEMELAM---KMLEKDVCEKQ 388
Q + +L +K L+ + QL+ +VE + ++ + A+ M+ +++ ++Q
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774
Query: 389 DALVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQMAATIKQL 443
D L + +L +L +L ++ G KQ +L +R+ E ++ K+
Sbjct: 1775 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKN 1834
Query: 444 EQSEKDLVK 452
+S K L K
Sbjct: 1835 TESVKGLRK 1843
Score = 37.0 bits (84), Expect = 0.039
Identities = 32/179 (17%), Positives = 79/179 (44%), Gaps = 15/179 (8%)
Query: 300 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 359
A + T++EE ++ K+E + E+ RK ++ Q ++ + ++ E++ LD
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKS-EAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 360 EKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRALK 405
E+ + I + ++E +K + + +++ D L++ +DDL
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 406 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
++ + +++ VK +E S L+E ++ K L+++ + + + N L
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSL 1021
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 60.5 bits (145), Expect = 3e-09
Identities = 57/242 (23%), Positives = 113/242 (46%), Gaps = 18/242 (7%)
Query: 242 LKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTE---E 298
LK + E + Q I + ++ +E + +L+ +++ L LTE E
Sbjct: 39 LKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKE 98
Query: 299 LAVANNRIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEARKHLKEETQL 355
L +A +R I +Q + R KEE LE+ ++ + + E + L+E K L E+ +
Sbjct: 99 LEIAQDRNIAIQSQFTRTKEE----LEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
Query: 356 RLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVS--------LRQQLDDLRALKHE 407
+ EL++++ Q ++++K EK + ++++ L S L+ + D+L AL E
Sbjct: 155 SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 408 LAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
++ ++ K E SRLEE+ N + + + L++ +DL+ + K + K
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
Query: 468 HH 469
H
Sbjct: 275 FH 276
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/206 (23%), Positives = 93/206 (45%), Gaps = 26/206 (12%)
Query: 275 NATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRK----G 330
N + LQ +V L NTK++ +L A+ R LQ+ +E + E + + E N+K
Sbjct: 694 NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATT 753
Query: 331 PKQDR-----------TAEGQALSEAR-KHLKEE------TQLRLDVEKELEMQISMRQE 372
KQ++ E A++E R ++LK+E +++RL ++E + Q
Sbjct: 754 QKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQN 813
Query: 373 MELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEK 432
+ L + + E+ + R + L+HE++ + + V+Q+ L L+ +
Sbjct: 814 LLLTNLQTIQGILERSETETKQRLS-SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQ 872
Query: 433 ---TNQMAATIKQLEQSEKDLVKQAK 455
T + T L + K+L+K A+
Sbjct: 873 LLDTKRQLDTETNLHLNTKELLKNAQ 898
Score = 40.8 bits (94), Expect = 0.003
Identities = 75/357 (21%), Positives = 152/357 (42%), Gaps = 55/357 (15%)
Query: 133 LELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSE 192
+E + KL+ EA E +++D V + + + +++K + K L N +LLS
Sbjct: 307 VEELHKLLKEAGEANKAIQDH---LLEVEQSKDQMEKEMLEK-IGRLEKELENANDLLSA 362
Query: 193 FYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTE 252
A++ EEE A ++ + A G L ++ Y++ +
Sbjct: 363 TKRKGAILSEEELAAMSPTAAAV----AKIVKPGMKLTEL-----YNAYVETQDQ----- 408
Query: 253 GDGQITAILDQKNYVEELNRHLNATVNNLQAKVDAL----------EKSNTKLTEELAVA 302
+L +K + +N++L+ V ++AK L +K+ L+ +L A
Sbjct: 409 -------LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461
Query: 303 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQ------ALSEARKH--LKEETQ 354
I LQE+ ++ ++SS + NR+ Q + Q L EAR + +++E
Sbjct: 462 MKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEV 521
Query: 355 LRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQS 414
D+ E+ + Q + ++ + +E+ + Q LV+LR +L + R + + +
Sbjct: 522 SSADISSSSEV---ISQHL-VSYRNIEELQQQNQRLLVALR-ELGETREREEQETTSSKI 576
Query: 415 SDLGVKQKS---ELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKH 468
++L +K +S EL + + +QM + Q + + ++T A IP H
Sbjct: 577 TELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVA----IPLH 629
Score = 40.8 bits (94), Expect = 0.003
Identities = 48/213 (22%), Positives = 94/213 (44%), Gaps = 27/213 (12%)
Query: 260 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRII------------ 307
+L+ K EE R L V+ + + LEK N L +++ +++++
Sbjct: 1124 LLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183
Query: 308 -TLQEE---MERVKEESSYILESNRKGPKQDRTAEGQALS-----EARKHLKEETQLRLD 358
+L EE E++ E +I + A+ ++L E + +E Q L+
Sbjct: 1184 VSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN 1243
Query: 359 VEKELEMQIS---MRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS 415
E+E ++Q++ M Q EL K +V + + + LR++ + L ++ K++
Sbjct: 1244 AERE-KVQVTAKTMAQHEELMKKTETMNVVMETNKM--LREEKERLEQDLQQMQAKVRKL 1300
Query: 416 DLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK 448
+L + E N+ L EK+ + A K LE+ K
Sbjct: 1301 ELDILPLQEANAELSEKSGMLQAEKKLLEEDVK 1333
Score = 37.4 bits (85), Expect = 0.029
Identities = 42/212 (19%), Positives = 98/212 (46%), Gaps = 31/212 (14%)
Query: 264 KNYVEE---LNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEES 320
+N VE+ L R+L+ + + + ++D + E L A I TL++ + ++ +
Sbjct: 856 ENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQV 915
Query: 321 SYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKML 380
+ RT +GQ + KE+ + ++ E Q++ +++ +K
Sbjct: 916 A--------SQSSQRTGKGQPSN------KEDVDDLVSQLRQTEEQVN---DLKERLKTS 958
Query: 381 EKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATI 440
+V + Q + SL + L+ + + E+ ++ ++ +K+ +E ++LE+K ++
Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVR---KNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
Query: 441 KQL--------EQSEKDLVKQAKTLNSAANKL 464
++L E E+ L + KTL+S N++
Sbjct: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEV 1047
Score = 36.6 bits (83), Expect = 0.050
Identities = 80/382 (20%), Positives = 156/382 (40%), Gaps = 52/382 (13%)
Query: 92 RTLDSDYAPLQQFFVVMEHCLKHG-LKAKKTFLGQNKSFWGP-------------LELVE 137
R L+ D PLQ+ + K G L+A+K L ++ W E
Sbjct: 1298 RKLELDILPLQEANAELSE--KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYR 1355
Query: 138 KLVPEAAEITASVKDLPG----LKTPVGRGRAWL--RLALMQKKLSEYMKALINKKELLS 191
KL+ E T ++ L LK + R A L L+Q L E + + +KE +
Sbjct: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS-LKEDLNKVRTEKETIQ 1414
Query: 192 EFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGT 251
+ + + ++E+ I + I + + E+L +Q K +S +
Sbjct: 1415 KDLDAKIIDIQEKVKTITQV----KKIGRRYKTQYEELKAQQD--------KVMETSAQS 1462
Query: 252 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQE 311
GD Q +Q V+E+ + L T+N + K +LE L + L+ LQE
Sbjct: 1463 SGDHQ-----EQHVSVQEM-QELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
Query: 312 EMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ 371
+ +++ E S + + QDRT + + L + +E+T+ + K +I+
Sbjct: 1517 QTVQLQSELSRLRQD-----LQDRTTQEEQLRQQITEKEEKTRKAIVAAKS---KIAHLA 1568
Query: 372 EMELAMKMLEKDVCEKQDALVSLRQQLD-DLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
++ + +++ ++ AL + +LD + ALK + ++ + +++ E LE
Sbjct: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE--RHLE 1626
Query: 431 EKTNQMAATIKQLEQSEKDLVK 452
++ + K EQ + +K
Sbjct: 1627 QRDEPQEPSNKVPEQQRQITLK 1648
Score = 29.6 bits (65), Expect = 6.1
Identities = 62/307 (20%), Positives = 129/307 (42%), Gaps = 30/307 (9%)
Query: 169 LALMQKKLSEYMKA---LINKKELLSEFYEP-NALMMEEEGAI--IAGLLVGLNVIDANF 222
LAL ++K +E ++ L NKKE +S E N L E + LL L
Sbjct: 209 LALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQ 268
Query: 223 CMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQ 282
E +++ ++K N K D + + + VEEL++ L +
Sbjct: 269 ASMEEKFHNELNA-----HIKLSNLYKSAADDSEAKSN-ELTRAVEELHKLLKEAGEANK 322
Query: 283 AKVDAL---EKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGP---KQDRT 336
A D L E+S ++ +E+ +I L++E+E + S + RKG +++
Sbjct: 323 AIQDHLLEVEQSKDQMEKEML---EKIGRLEKELENANDLLS---ATKRKGAILSEEELA 376
Query: 337 AEGQALSEARKHLKEETQLR------LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 390
A + K +K +L ++ + +L ++ + + + + K+V K
Sbjct: 377 AMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPI 436
Query: 391 LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDL 450
L R++ + + L+ KL+ + +++ E + ++++ + +++E KDL
Sbjct: 437 LKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDL 496
Query: 451 VKQAKTL 457
+Q + L
Sbjct: 497 SQQIRVL 503
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 59.3 bits (142), Expect = 7e-09
Identities = 46/217 (21%), Positives = 104/217 (47%), Gaps = 16/217 (7%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 306
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 922 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 981
Query: 307 ITLQEEM-------ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 359
L EEM ++ +E + E++++ + E + + + +K E Q+ D+
Sbjct: 982 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DL 1040
Query: 360 EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV 419
E LE + +R ++E A + LE D+ Q++++ + + L + F++ + +
Sbjct: 1041 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 420 KQKSELNSRLEEKTNQMAATIKQLEQS-EKDLVKQAK 455
+ + L +L++K ++ A I++LE+ E + +AK
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Score = 56.6 bits (135), Expect = 5e-08
Identities = 52/230 (22%), Positives = 115/230 (50%), Gaps = 37/230 (16%)
Query: 252 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 306
EGD ++ +I+D +N ++L+ L ++NLQ+K++ + +L +++ RI
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 307 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEK 361
L+EE+E + ++R ++ R+ + L E + L+E Q+ ++ ++
Sbjct: 1122 EELEEEIEAER--------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1173
Query: 362 ELEMQISMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHELAFKLQSSDL 417
E E Q MR+++E A E + D++ L +Q+D+L+ +K +L
Sbjct: 1174 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE-------- 1224
Query: 418 GVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
K+KSE+ +++ +A+ ++ + +++ +L K +TL ++L K
Sbjct: 1225 --KEKSEMKMEIDD----LASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/212 (22%), Positives = 93/212 (43%), Gaps = 34/212 (16%)
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG------------P 331
+V L NT L I +Q EME + +E+ E +K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 332 KQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ--EMELAMKMLEKDVCEKQ- 388
+QD +A + + + + ++ QLRLD ++L ++ +Q ++E ++ LE +V +Q
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 389 ---DALVSLRQQLDDLRALKHE-------------LAFKLQSSDLGVKQKSELNSRLEEK 432
+A+ LR+ ++ L ++ L KLQ+ K+++E EE+
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE---EAEEQ 1894
Query: 433 TNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+N A ++L+ ++ ++A S NKL
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Score = 42.7 bits (99), Expect = 7e-04
Identities = 67/317 (21%), Positives = 129/317 (40%), Gaps = 55/317 (17%)
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 230
K EL + E A + EEG I+ + + LN + D K E++D
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601
Query: 231 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 283
S +D + ++ + +G + + Q N+ + R+ + + Q
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 342
+D +S L E+LA+ R LQ E+E ++ LE + K AE + L
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA----TLEQTERSRK---IAEQELLD 1714
Query: 343 -SEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMK-----------------MLEKD 383
SE + L + ++ +K+LE IS M+ EME ++ M+ ++
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQMAA 438
+ ++QD L + ++ +L +L ++ G KQ +L +R+ E ++ +
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES 1834
Query: 439 TIKQLEQSEKDLVKQAK 455
K+ ++ K L K +
Sbjct: 1835 EQKRNAEAVKGLRKHER 1851
Score = 37.4 bits (85), Expect = 0.029
Identities = 53/208 (25%), Positives = 88/208 (42%), Gaps = 33/208 (15%)
Query: 277 TVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT 336
+V L ++D L++ KL +E + I L +E V + + K RT
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL-------EKMCRT 1257
Query: 337 AEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ-------- 388
E Q LSE + KEE Q RL + + + E + ++ EK+ Q
Sbjct: 1258 LEDQ-LSELKS--KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF 1314
Query: 389 -DALVSLRQQLDDLRALKHELAFKLQSS----DLGVKQ-------KSELNSRLEEKTNQM 436
+ L++QL++ K+ LA LQSS DL +Q K+EL L + ++
Sbjct: 1315 TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEV 1374
Query: 437 AATIKQLEQSEKDLVKQAKTLNSAANKL 464
A + + E D +++ + L A KL
Sbjct: 1375 A---QWRTKYETDAIQRTEELEEAKKKL 1399
Score = 36.6 bits (83), Expect = 0.050
Identities = 45/231 (19%), Positives = 102/231 (44%), Gaps = 28/231 (12%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITL------------ 309
+Q VE L A + L+A ++ E+S +EL A+ R+ L
Sbjct: 1675 EQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1734
Query: 310 --QEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEE-TQLRLD-VEKELE- 364
+ ++ +++ E IL+ R ++ + A A A + KE+ T L+ ++K +E
Sbjct: 1735 KLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1794
Query: 365 ----MQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
+Q+ + + +LA+K +K + + + + L +++ + E L+ + VK
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854
Query: 421 QKSELNS-------RLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+ + RL++ +++ A +K ++ ++ +Q+ T + KL
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKL 1905
Score = 35.8 bits (81), Expect = 0.086
Identities = 44/214 (20%), Positives = 86/214 (40%), Gaps = 23/214 (10%)
Query: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 323
+N VE+L + T A AL+K + LA + E+E ++E+ +
Sbjct: 1428 QNEVEDLMLDVERT----NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 324 LES--NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE 381
K ++ + + L K+L++E D+ +++ E+E K +E
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEIS---DLTEQIAEGGKRIHELEKIKKQVE 1540
Query: 382 KDVCEKQDALVSLRQQLD-----------DLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
++ CE Q AL L+ +L +K E+ K+ D + Q + R+
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIV 1600
Query: 431 EKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
E M +T+ +S D ++ K + N++
Sbjct: 1601 E---SMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Score = 35.0 bits (79), Expect = 0.15
Identities = 40/173 (23%), Positives = 83/173 (47%), Gaps = 15/173 (8%)
Query: 287 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 346
AL K+NT++ + I EE+E K++ + L++ + + A+ +L + +
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE-HVEAVNAKCASLEKTK 1424
Query: 347 KHLKEETQ-LRLDVEKELEMQISMRQEMELAMKMLE--KDVCEKQDALVSLRQQLDDLRA 403
+ L+ E + L LDVE+ ++ ++ K+L K CE+ A + Q+ + R+
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK--EARS 1482
Query: 404 LKHELAFKLQSS--------DLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK 448
L EL FK++++ + ++ L + + T Q+A K++ + EK
Sbjct: 1483 LGTEL-FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Score = 33.9 bits (76), Expect = 0.33
Identities = 30/179 (16%), Positives = 77/179 (43%), Gaps = 15/179 (8%)
Query: 300 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT--------------AEGQALSEA 345
A + T++EE +++K+E + E+ RK ++ AE + L++A
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKS-EAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 346 RKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 405
+ + + ++ +E +++ ++ E L + +D L++ +DDL
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 406 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
++ + +++ VK +E + L+E ++ K L+++ + + + N L
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 59.3 bits (142), Expect = 7e-09
Identities = 46/217 (21%), Positives = 104/217 (47%), Gaps = 16/217 (7%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 306
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 922 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 981
Query: 307 ITLQEEM-------ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 359
L EEM ++ +E + E++++ + E + + + +K E Q+ D+
Sbjct: 982 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DL 1040
Query: 360 EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV 419
E LE + +R ++E A + LE D+ Q++++ + + L + F++ + +
Sbjct: 1041 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 420 KQKSELNSRLEEKTNQMAATIKQLEQS-EKDLVKQAK 455
+ + L +L++K ++ A I++LE+ E + +AK
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137
Score = 56.6 bits (135), Expect = 5e-08
Identities = 52/230 (22%), Positives = 115/230 (50%), Gaps = 37/230 (16%)
Query: 252 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 306
EGD ++ +I+D +N ++L+ L ++NLQ+K++ + +L +++ RI
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 307 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEK 361
L+EE+E + ++R ++ R+ + L E + L+E Q+ ++ ++
Sbjct: 1122 EELEEEIEAER--------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1173
Query: 362 ELEMQISMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHELAFKLQSSDL 417
E E Q MR+++E A E + D++ L +Q+D+L+ +K +L
Sbjct: 1174 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE-------- 1224
Query: 418 GVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
K+KSE+ +++ +A+ ++ + +++ +L K +TL ++L K
Sbjct: 1225 --KEKSEMKMEIDD----LASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/212 (22%), Positives = 93/212 (43%), Gaps = 34/212 (16%)
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG------------P 331
+V L NT L I +Q EME + +E+ E +K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 332 KQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ--EMELAMKMLEKDVCEKQ- 388
+QD +A + + + + ++ QLRLD ++L ++ +Q ++E ++ LE +V +Q
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 389 ---DALVSLRQQLDDLRALKHE-------------LAFKLQSSDLGVKQKSELNSRLEEK 432
+A+ LR+ ++ L ++ L KLQ+ K+++E EE+
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE---EAEEQ 1894
Query: 433 TNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+N A ++L+ ++ ++A S NKL
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKL 1926
Score = 42.7 bits (99), Expect = 7e-04
Identities = 67/317 (21%), Positives = 129/317 (40%), Gaps = 55/317 (17%)
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 230
K EL + E A + EEG I+ + + LN + D K E++D
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601
Query: 231 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 283
S +D + ++ + +G + + Q N+ + R+ + + Q
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 342
+D +S L E+LA+ R LQ E+E ++ LE + K AE + L
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA----TLEQTERSRK---IAEQELLD 1714
Query: 343 -SEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMK-----------------MLEKD 383
SE + L + ++ +K+LE IS M+ EME ++ M+ ++
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQMAA 438
+ ++QD L + ++ +L +L ++ G KQ +L +R+ E ++ +
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES 1834
Query: 439 TIKQLEQSEKDLVKQAK 455
K+ ++ K L K +
Sbjct: 1835 EQKRNAEAVKGLRKHER 1851
Score = 37.4 bits (85), Expect = 0.029
Identities = 53/208 (25%), Positives = 88/208 (42%), Gaps = 33/208 (15%)
Query: 277 TVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT 336
+V L ++D L++ KL +E + I L +E V + + K RT
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL-------EKMCRT 1257
Query: 337 AEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ-------- 388
E Q LSE + KEE Q RL + + + E + ++ EK+ Q
Sbjct: 1258 LEDQ-LSELKS--KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF 1314
Query: 389 -DALVSLRQQLDDLRALKHELAFKLQSS----DLGVKQ-------KSELNSRLEEKTNQM 436
+ L++QL++ K+ LA LQSS DL +Q K+EL L + ++
Sbjct: 1315 TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEV 1374
Query: 437 AATIKQLEQSEKDLVKQAKTLNSAANKL 464
A + + E D +++ + L A KL
Sbjct: 1375 A---QWRTKYETDAIQRTEELEEAKKKL 1399
Score = 36.6 bits (83), Expect = 0.050
Identities = 45/231 (19%), Positives = 102/231 (44%), Gaps = 28/231 (12%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITL------------ 309
+Q VE L A + L+A ++ E+S +EL A+ R+ L
Sbjct: 1675 EQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1734
Query: 310 --QEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEE-TQLRLD-VEKELE- 364
+ ++ +++ E IL+ R ++ + A A A + KE+ T L+ ++K +E
Sbjct: 1735 KLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQ 1794
Query: 365 ----MQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
+Q+ + + +LA+K +K + + + + L +++ + E L+ + VK
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854
Query: 421 QKSELNS-------RLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+ + RL++ +++ A +K ++ ++ +Q+ T + KL
Sbjct: 1855 ELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKL 1905
Score = 35.8 bits (81), Expect = 0.086
Identities = 44/214 (20%), Positives = 86/214 (40%), Gaps = 23/214 (10%)
Query: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 323
+N VE+L + T A AL+K + LA + E+E ++E+ +
Sbjct: 1428 QNEVEDLMLDVERT----NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 324 LES--NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE 381
K ++ + + L K+L++E D+ +++ E+E K +E
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEIS---DLTEQIAEGGKRIHELEKIKKQVE 1540
Query: 382 KDVCEKQDALVSLRQQLD-----------DLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
++ CE Q AL L+ +L +K E+ K+ D + Q + R+
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIV 1600
Query: 431 EKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
E M +T+ +S D ++ K + N++
Sbjct: 1601 E---SMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Score = 35.0 bits (79), Expect = 0.15
Identities = 40/173 (23%), Positives = 83/173 (47%), Gaps = 15/173 (8%)
Query: 287 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 346
AL K+NT++ + I EE+E K++ + L++ + + A+ +L + +
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE-HVEAVNAKCASLEKTK 1424
Query: 347 KHLKEETQ-LRLDVEKELEMQISMRQEMELAMKMLE--KDVCEKQDALVSLRQQLDDLRA 403
+ L+ E + L LDVE+ ++ ++ K+L K CE+ A + Q+ + R+
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK--EARS 1482
Query: 404 LKHELAFKLQSS--------DLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK 448
L EL FK++++ + ++ L + + T Q+A K++ + EK
Sbjct: 1483 LGTEL-FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Score = 33.9 bits (76), Expect = 0.33
Identities = 30/179 (16%), Positives = 77/179 (43%), Gaps = 15/179 (8%)
Query: 300 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT--------------AEGQALSEA 345
A + T++EE +++K+E + E+ RK ++ AE + L++A
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKS-EAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 346 RKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 405
+ + + ++ +E +++ ++ E L + +D L++ +DDL
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 406 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
++ + +++ VK +E + L+E ++ K L+++ + + + N L
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
>gi|40538728 pleckstrin homology domain containing, family M (with
RUN domain) member 1 [Homo sapiens]
Length = 1056
Score = 58.2 bits (139), Expect = 2e-08
Identities = 48/167 (28%), Positives = 73/167 (43%), Gaps = 20/167 (11%)
Query: 79 SIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFL---GQNKS------- 128
S+K L + ++L + S+ +E HGL AK G+ K
Sbjct: 25 SVKALQKQYVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAEAGGKRKKSAHQKPL 84
Query: 129 ----FWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
FW L+ V I + ++ L + T VGR RAWLRLAL + Y+K L+
Sbjct: 85 PQPVFWPLLKAVTH-----KHIISELEHLTFVNTDVGRCRAWLRLALNDGLMECYLKLLL 139
Query: 185 NKKELLSEFYEPNALMME-EEGAIIAGLLVGLNVIDANFCMKGEDLD 230
++ L E+Y+P AL+ + EEG + L GL + K L+
Sbjct: 140 QEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYKSAILN 186
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.2 bits (139), Expect = 2e-08
Identities = 55/240 (22%), Positives = 114/240 (47%), Gaps = 24/240 (10%)
Query: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
+S K E + ++T +D+ ++VE++N+ + A LQ ++ + + +L EEL+ NR
Sbjct: 2588 SSYKNLENELELTK-MDKMSFVEKVNK-MTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
Query: 306 II-TLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLK-----EETQLRL-D 358
+ LQ +E +K + E + + ++ + + K K E QLRL +
Sbjct: 2646 LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHE 2705
Query: 359 VEKELE-MQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSD- 416
EK+ + + + ++ E+ ++ + + K++ L S + ++D L++ K EL L+++
Sbjct: 2706 AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQ 2765
Query: 417 -------------LGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANK 463
V Q + N R + K + + KQLE+ ++ L K+ L +A K
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
Score = 45.4 bits (106), Expect = 1e-04
Identities = 58/315 (18%), Positives = 137/315 (43%), Gaps = 28/315 (8%)
Query: 168 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 227
+L L + +L ++A I ++++ E + N+ + E+ L ++ + + +
Sbjct: 1810 KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSD 1869
Query: 228 -----DLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQ 282
D S+ + D + D + + + +++ I +K +E +L A + +Q
Sbjct: 1870 LEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQ 1929
Query: 283 AKVDALEKSNTK-------LTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDR 335
+ LEK N L EEL+V + L+ E++ + ++++ + + + K ++ +
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 336 TAEGQ------ALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQD 389
E + A +KE+T+L + ++ + + ++ ++ LEKD
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD----SQ 2045
Query: 390 ALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKD 449
AL + +L+ +++A + +L VK+ L +RL E + K LE + +
Sbjct: 2046 ALSLTKCELE------NQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVE 2099
Query: 450 LVKQAKTLNSAANKL 464
+ A L+S ++
Sbjct: 2100 KGEFALRLSSTQEEV 2114
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/196 (25%), Positives = 89/196 (45%), Gaps = 27/196 (13%)
Query: 263 QKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSY 322
+K + EEL+R + Q + +LT+EL A N LQ E++++
Sbjct: 393 EKEFQEELSRQQRS----FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
Query: 323 ILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE- 381
LE+N + KQ QA ++ +E +LR +E+ M++E L E
Sbjct: 449 -LENNLEEFKQKLCRAEQAFQASQ---IKENELRRSMEE-------MKKENNLLKSHSEQ 497
Query: 382 --KDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQM--A 437
++VC + L +++Q L+ + E+ K S + ++ L+EK NQ +
Sbjct: 498 KAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD-------LQEKINQQENS 550
Query: 438 ATIKQLEQSEKDLVKQ 453
T+++L+ + DL KQ
Sbjct: 551 LTLEKLKLAVADLEKQ 566
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/200 (19%), Positives = 91/200 (45%), Gaps = 20/200 (10%)
Query: 276 ATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME-RVKEESSYILESNRKGPKQD 334
A + K ALE+ KLTE+L+ + + +E ++KE+ E + +
Sbjct: 348 AQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407
Query: 335 RTAEGQALS-EAR--KHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDAL 391
+T + + + +AR + L++ + ++ EL+ S++Q++E ++ ++ +C + A
Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF 467
Query: 392 VSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMA------ATIKQLEQ 445
+ + + ++LR E+ K+ + L S E+K ++ IKQ
Sbjct: 468 QASQIKENELRRSMEEMK----------KENNLLKSHSEQKAREVCHLEAELKNIKQCLN 517
Query: 446 SEKDLVKQAKTLNSAANKLI 465
++ ++ K N++ ++
Sbjct: 518 QSQNFAEEMKAKNTSQETML 537
Score = 40.4 bits (93), Expect = 0.003
Identities = 65/264 (24%), Positives = 111/264 (42%), Gaps = 46/264 (17%)
Query: 237 DFSMYLKDGN----SSKGTEGDGQITAIL--DQKNYVEELNRHLNATVN---NLQAKVDA 287
D S LKD + E D Q ++ + +N + +LN+ V +LQA++
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 288 --LEKSNTKLTEELAVANN-----RIITLQEEMERVK---EESSYILESNRKGPK----- 332
EK N E A+ R+ + QEE+ +++ E+ +E++ K
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 333 -QDRTAEGQALSEARKHLKEETQLR--------LDVEK---ELEMQISMRQEMELAMKML 380
++R E +L + ++L+ E Q+ LD E E+E + +EM ++K+
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 381 EKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATI 440
E D LV+LR + ++L E +L D K S S LEEK
Sbjct: 2202 ELD-------LVTLRSEKENLTKQIQEKQGQLSELD---KLLSSFKSLLEEKEQAEIQIK 2251
Query: 441 KQLEQSEKDLVKQAKTLNSAANKL 464
++ + + + L Q K LN A L
Sbjct: 2252 EESKTAVEMLQNQLKELNEAVAAL 2275
Score = 35.4 bits (80), Expect = 0.11
Identities = 42/185 (22%), Positives = 81/185 (43%), Gaps = 20/185 (10%)
Query: 278 VNNLQAKVDALEKSNTKLTEELAVAN----NRIITLQEEMERVKEESSYILESNRKGPKQ 333
V L+AK++ + +S L ++ N LQ+E ER+ E I+ S+ + Q
Sbjct: 2366 VETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE--IINSSFENILQ 2423
Query: 334 DRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDAL-- 391
++ E + E E Q +L KEL +++ + A K E+++ + + L
Sbjct: 2424 EKEQEKVQMKEKSSTAMEMLQTQL---KELNERVAALHNDQEACKAKEQNLSSQVECLEL 2480
Query: 392 --VSLRQQLDD-------LRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQ 442
L Q LD+ L++ + L +++ +++K E SRL+ + + +
Sbjct: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSK 2540
Query: 443 LEQSE 447
L Q E
Sbjct: 2541 LSQVE 2545
Score = 33.9 bits (76), Expect = 0.33
Identities = 24/116 (20%), Positives = 63/116 (54%), Gaps = 2/116 (1%)
Query: 340 QALSEARKHLKEETQLRLDV-EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQL 398
+A ++ ++ E +LRL EKE++ Q++ QE++L ++ + ++ EK+ L R +L
Sbjct: 284 KAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDEL 343
Query: 399 DDLRALKHELAFKLQSSDLGVKQKSE-LNSRLEEKTNQMAATIKQLEQSEKDLVKQ 453
A + + K + + +K+ +E L+ + + + + +++++ EK+ ++
Sbjct: 344 VRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399
Score = 32.7 bits (73), Expect = 0.73
Identities = 42/199 (21%), Positives = 91/199 (45%), Gaps = 31/199 (15%)
Query: 281 LQAKVDALE---KSNTKLTEELAVANNRIITLQEEMER--VKEES---SYILESNRKGPK 332
LQ +VD+LE +S ++ +L ++ ++ E+E +K E S++ E++++ K
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
Query: 333 --QDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 390
+D +A ++E L+ + EKEL++ + + ++ L+K +D+
Sbjct: 888 LQEDTSAHQNVVAETLSALENK-------EKELQLLNDKVETEQAEIQELKKSNHLLEDS 940
Query: 391 LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEE--------------KTNQM 436
L L+ + L K E++ + + +++ ++ N L+E K+
Sbjct: 941 LKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
Query: 437 AATIKQLEQSEKDLVKQAK 455
A I + E+S +L Q K
Sbjct: 1001 ANYIDEREKSISELSDQYK 1019
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 57.8 bits (138), Expect = 2e-08
Identities = 50/220 (22%), Positives = 106/220 (48%), Gaps = 22/220 (10%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 306
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 920 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 979
Query: 307 ITLQEEM-------ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 359
L EEM ++ +E + E++++ + E + + + +K E Q+ D+
Sbjct: 980 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DL 1038
Query: 360 EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL---RQQLDDLRALKHELAFKLQSSD 416
E LE + +R ++E A + LE D+ Q++ + + +QQLD+ K F++
Sbjct: 1039 EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE---FEMSGLQ 1095
Query: 417 LGVKQKSELNSRLEEKTNQMAATIKQLEQS-EKDLVKQAK 455
++ + L +L++K ++ A I++LE+ E + +AK
Sbjct: 1096 SKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK 1135
Score = 44.3 bits (103), Expect = 2e-04
Identities = 69/317 (21%), Positives = 129/317 (40%), Gaps = 55/317 (17%)
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 230
K EL + E A + EEG I+ + + LN + D K E++D
Sbjct: 1541 KSELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVE 1599
Query: 231 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 283
S +D + ++ + +G + + Q N+ + R+ A + + Q
Sbjct: 1600 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL 1659
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 342
+D +S L E+LA+ R LQ E+E ++ LE + K AE + L
Sbjct: 1660 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA----TLEQTERSRK---IAEQELLD 1712
Query: 343 -SEARKHLKEETQLRLDVEKELEMQISMRQ-EMELAMK-----------------MLEKD 383
SE + L + ++ +K+LE IS Q EME ++ M+ ++
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEE 1772
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQMAA 438
+ ++QD L + +L +L +L ++ G KQ +L +R+ E ++ +
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVES 1832
Query: 439 TIKQLEQSEKDLVKQAK 455
K+ ++ K L K +
Sbjct: 1833 EQKRNVEAVKGLRKHER 1849
Score = 39.7 bits (91), Expect = 0.006
Identities = 45/208 (21%), Positives = 81/208 (38%), Gaps = 45/208 (21%)
Query: 268 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESN 327
+ L L + LQA+++ LE+ A A + L E+E + E
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE--------- 1152
Query: 328 RKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVC-- 385
R E + A Q+ ++ ++E E Q MR+++E A E
Sbjct: 1153 -------RLEEAGGATSA--------QIEMNKKREAEFQ-KMRRDLEEATLQHEATAATL 1196
Query: 386 --EKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 443
+ D++ L +Q+D+L+ +K +L K+KSE+ +++ + M K
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLE----------KEKSEMKMEIDDLASNMETVSKAK 1246
Query: 444 EQSEK------DLVKQAKTLNSAANKLI 465
EK D + + KT +LI
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLI 1274
Score = 34.3 bits (77), Expect = 0.25
Identities = 31/179 (17%), Positives = 75/179 (41%), Gaps = 15/179 (8%)
Query: 300 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 359
A + ++EE E+ KEE + E+ RK ++ Q ++ + ++ E D
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKT-EAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 360 EKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRALK 405
E+ + I + ++E +K + + +++ D L++ +DDL
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 406 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
++ + +++ VK +E + L+E ++ K L+++ + + + N L
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.6 bits (135), Expect = 5e-08
Identities = 47/220 (21%), Positives = 107/220 (48%), Gaps = 24/220 (10%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 321
++ ++ + + A + +L+ ++D E + KL E A +I ++EE+ +++++S
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 322 YILESNRKGPKQDRTAE-GQALSEARKHLKEETQLR-------LDVEKELEMQISMRQEM 373
++ + +DR AE L+E + K ++R D+E+ L+ + RQE+
Sbjct: 996 KFIKEKKL--MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 374 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS-----------DLGVKQK 422
E A + L+ + + QD + L+ Q+D+L+ + +LQ + + +K
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 423 SELNSR---LEEKTNQMAATIKQLEQSEKDLVKQAKTLNS 459
EL ++ L+E A+ + E+ ++DL ++ + L +
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT 1153
Score = 55.8 bits (133), Expect = 8e-08
Identities = 60/237 (25%), Positives = 104/237 (43%), Gaps = 25/237 (10%)
Query: 243 KDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA 302
K G + E ++ + K E + L+A V L AKV ++ +L E+ +
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS-- 1283
Query: 303 NNRIITLQEEMERVKEESSYILESNRKGPK--QDRTAEGQALSEARKHLKEETQLRLDV- 359
LQ E++ V S+ + E+ +KG K +D + L + ++ L+EET+ +L++
Sbjct: 1284 -----KLQNELDNV---STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 360 ------EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ 413
E+E ++E E A K LEK V Q L ++++DD L +
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE---E 1392
Query: 414 SSDLGVKQKSELNSRLEEKT---NQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
+ +K L+ RLEEK +++ T +L+Q DL A+ L K
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/200 (22%), Positives = 92/200 (46%), Gaps = 16/200 (8%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 313
L+ K E N+ L A + +L + D LEKS L +++ ++ L++E+
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 314 ERVKEESSYILESNRKGPKQD-----RTAEGQALSEARKHLKEETQLRLDVE---KELEM 365
+ E++ LE N + K +T + Q + R +K+ +L ++E K+ +
Sbjct: 1556 QAT-EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 366 QISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSEL 425
++ +++ME+ +K LE + A + +QL L+A + +L+ + +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674
Query: 426 NSRLEEKTNQMAATIKQLEQ 445
+ E+K + A I QL++
Sbjct: 1675 SKESEKKLKSLEAEILQLQE 1694
Score = 44.3 bits (103), Expect = 2e-04
Identities = 45/197 (22%), Positives = 87/197 (44%), Gaps = 16/197 (8%)
Query: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 323
KN ++ R L A + LQ ++ + S K A + L EE+E +K E
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNK-------AEKQKRDLSEELEALKTELEDT 1158
Query: 324 LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEK 382
L++ ++ RT Q ++E +K L+EET K E QI MRQ A++ L +
Sbjct: 1159 LDTTA-AQQELRTKREQEVAELKKALEEET-------KNHEAQIQDMRQRHATALEELSE 1210
Query: 383 DVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQ 442
+ + + +L + L ELA +++ + +L+ + ++ A + +
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE 1270
Query: 443 LEQSEKDLVKQAKTLNS 459
++ +L ++A L +
Sbjct: 1271 GDRLRVELAEKASKLQN 1287
Score = 43.9 bits (102), Expect = 3e-04
Identities = 49/226 (21%), Positives = 103/226 (45%), Gaps = 23/226 (10%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDA-LEKSNTKLTEELAVANNRIITLQEEME 314
Q+ + D+ E+ L + ++A+ + L+ + + E+ + ++ L+ E+E
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 315 RVKEESSYILESNRKGP--KQDRTAEGQALSEAR----KHLKEETQLRLDVEKELEMQIS 368
+++ + + S +K +D A+ +A ++AR K L++ D ++ELE +
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 369 MRQEM-------ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ 421
R E+ E +K LE ++ + Q+ L S + + ELA ++ +S G
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 422 KSELNSRLEEKTNQMAATIKQLEQSEKDLVK--------QAKTLNS 459
+ RLE + Q+ +++ EQS +L+ Q TLN+
Sbjct: 1727 LLDEKRRLEARIAQLEEELEE-EQSNMELLNDRFRKTTLQVDTLNA 1771
Score = 42.0 bits (97), Expect = 0.001
Identities = 46/219 (21%), Positives = 95/219 (43%), Gaps = 9/219 (4%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEM 313
+ +I + ++ E RH + L ++ + L +E RI L+EE+
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745
Query: 314 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 373
E + + + RK Q T + +E R ++ R +E++ + + QE+
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 374 ELAMKMLEKDVCEKQDALV-SLRQQLDD---LRALKHELA----FKLQSSDLGVKQKSEL 425
E A+K K +A + L +QL+ RA ++L KL+ + V+ +
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 426 NSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+ +E+ + A +KQL++ ++ ++A N++ KL
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKL 1903
Score = 39.3 bits (90), Expect = 0.008
Identities = 39/201 (19%), Positives = 80/201 (39%), Gaps = 7/201 (3%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERV---KEESSYI 323
V+E + + ++ K L + L E+L +E R+ K+E I
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 324 LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKD 383
L + + ++ Q L +K ++ Q D+E++L+ + RQ+++L E
Sbjct: 924 LH-DLESRVEEEEERNQILQNEKKKMQAHIQ---DLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 443
+ + ++ ++ L Q K + ++ + ++ E L + N+ I L
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 444 EQSEKDLVKQAKTLNSAANKL 464
E+ K K + L A KL
Sbjct: 1040 EERLKKEEKTRQELEKAKRKL 1060
Score = 35.0 bits (79), Expect = 0.15
Identities = 41/250 (16%), Positives = 98/250 (39%), Gaps = 7/250 (2%)
Query: 215 LNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHL 274
L ++A E+L S + +D + + T +A+LD+K +E L
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 275 NATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD 334
+ Q+ ++ L K T ++ N + + ++ + N++ +
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801
Query: 335 RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL 394
+ EG S+ + + +E++LE + R ++ EK + E +
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKE-------I 1854
Query: 395 RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQA 454
Q++D R + +++ ++ +KQ EE+ + A+ ++L++ D +
Sbjct: 1855 FMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Query: 455 KTLNSAANKL 464
+ L+ + L
Sbjct: 1915 EGLSREVSTL 1924
Score = 31.2 bits (69), Expect = 2.1
Identities = 39/218 (17%), Positives = 85/218 (38%), Gaps = 20/218 (9%)
Query: 247 SSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAK--------------VDALEKSN 292
SS+ + + + ++ +Q+ EE ++L V LQ++ +++LE++
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394
Query: 293 TKLTEELAVANNRI---ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKH- 348
KL ++ + R+ +++E+ K L+ R + +K
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 349 --LKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKH 406
L EE + +E + + +E E L + + E +A +Q LRA
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 407 ELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLE 444
+L V + + LE++ +M +++LE
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 56.2 bits (134), Expect = 6e-08
Identities = 51/238 (21%), Positives = 106/238 (44%), Gaps = 30/238 (12%)
Query: 254 DGQITAILDQKNYVEELN-------RHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI 306
+G++ + ++ EE+N R L L+ +D L+ + K +E N++
Sbjct: 965 EGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKV 1024
Query: 307 ITLQEEM-------ERVKEESSYILESNRK--GPKQDRTAEGQALSEARKHLKEETQLRL 357
L EEM R+ +E + E++++ G Q AL++A+ L+++ +
Sbjct: 1025 KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVE--- 1081
Query: 358 DVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDL 417
D+E LE + +R + E A + LE D+ Q+++ Q L + +L L
Sbjct: 1082 DLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSL 1141
Query: 418 GVKQKSELNSRLEEKTNQMAATIKQLEQS-----------EKDLVKQAKTLNSAANKL 464
V+ + L +++++K ++ A ++LE+ EK + A+ L + +L
Sbjct: 1142 RVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERL 1199
Score = 43.1 bits (100), Expect = 5e-04
Identities = 56/224 (25%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 259 AILDQKNYVEELNRHLNATVNN---LQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
A+ +++ EE+ R L A L ++ L + + E L LQEE+
Sbjct: 1501 ALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISD 1560
Query: 316 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-ETQLRLDVEKELEMQISMRQ-EM 373
+ ++ S +S ++ K + EG+ SE + L+E E L L+ K L +Q+ + Q +
Sbjct: 1561 LTDQVSLSGKSIQELEKTKKALEGEK-SEIQAALEEAEGALELEETKTLRIQLELSQVKA 1619
Query: 374 ELAMKMLEKD-VC-----EKQDALVSLRQQLD-DLRA------LKHELAFKLQSSDLGVK 420
E+ K+ EKD C Q A+ SL+ LD + RA LK ++ L +L +
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKL 464
+ + + T M A +K+ + + + A L+ A L
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQAL 1723
Score = 40.8 bits (94), Expect = 0.003
Identities = 48/223 (21%), Positives = 97/223 (43%), Gaps = 38/223 (17%)
Query: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 323
K E+L R ++ + KV+ L++ + + R+ T E+ R+ EE +
Sbjct: 1291 KASAEKLCRTYEDQLSEAKIKVEELQRQ----LADASTQRGRLQTESGELSRLLEEKECL 1346
Query: 324 LESNRKGPKQDRTAEGQALSEARKHLKEETQ-----------LRLDVE---KELEMQISM 369
+ +G + Q+L E R+ L+EE++ LR D + ++ E +
Sbjct: 1347 ISQLSRG----KALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA 1402
Query: 370 RQEMELAMKMLEKDVCE-----KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE 424
+ E++ + +V + + DA+ Q+ ++L K +LA +LQ ++ GV+ +
Sbjct: 1403 QAELQRLLSKANAEVAQWRSKYEADAI----QRTEELEEAKKKLALRLQEAEEGVEAANA 1458
Query: 425 LNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPK 467
S LE+ +L+ +D+ + + SAA L K
Sbjct: 1459 KCSSLEKAK-------LRLQTESEDVTLELERATSAAAALDKK 1494
Score = 38.1 bits (87), Expect = 0.017
Identities = 44/213 (20%), Positives = 99/213 (46%), Gaps = 16/213 (7%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
+I+ + DQ + + + L T L+ + ++ + + L + + + +Q E+ +
Sbjct: 1557 EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQ 1616
Query: 316 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQE 372
VK E L + R +A+ + L ET+ R L ++K++E ++ +
Sbjct: 1617 VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN---D 1673
Query: 373 MELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHE---LAFKLQSSDLGVKQKSELNSRL 429
+EL + + E Q A ++ QL + +A + E LA +L +++++ L L
Sbjct: 1674 LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL---L 1730
Query: 430 EEKTNQMAATIKQLEQS----EKDLVKQAKTLN 458
+ ++ A ++Q E+S E++L++ + LN
Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLN 1763
Score = 37.7 bits (86), Expect = 0.023
Identities = 40/186 (21%), Positives = 92/186 (49%), Gaps = 20/186 (10%)
Query: 284 KVDALEKSNTKLT-------EELAVANNRIITLQEEMERVKEESSYI-LESNRKGPKQDR 335
+ + LE++ KL E + AN + +L++ R++ ES + LE R
Sbjct: 1431 RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERA------ 1484
Query: 336 TAEGQALSEARKHLKE--ETQLRLDVEKELEMQISMRQEMELAMKM--LEKDVCEKQDAL 391
T+ AL + ++HL+ E + R + E + E++ + R+ L ++ L E +AL
Sbjct: 1485 TSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL 1544
Query: 392 VSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLV 451
+L+++ +L+ +L ++ S +++ + LE + +++ A +++ E + + +
Sbjct: 1545 ETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALE--L 1602
Query: 452 KQAKTL 457
++ KTL
Sbjct: 1603 EETKTL 1608
Score = 36.6 bits (83), Expect = 0.050
Identities = 68/318 (21%), Positives = 124/318 (38%), Gaps = 66/318 (20%)
Query: 171 LMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD 230
LMQ +L E ++ L +E +E A +E +++A L E+L
Sbjct: 1694 LMQAQLKEEQAGRDEEQRLAAELHE-QAQALERRASLLAAEL--------------EELR 1738
Query: 231 SQVGVIDFSMYLKDGNSSKGTEG----DGQITAILDQKNYVEELNRHLNATVNNL-QAKV 285
+ + + S L + + TE Q T +L+QK +E L+ V Q +
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERR 1798
Query: 286 DALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEA 345
+A EK+ +T+ +A E +K+E QD +A + + +
Sbjct: 1799 EAEEKAKKAITDAAMMA-----------EELKKE-------------QDTSAHLERMKKT 1834
Query: 346 RKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE----------------KDVCEKQD 389
+ E Q RL+ ++ ++ +Q +L K+ E K V + +
Sbjct: 1835 LEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHER 1894
Query: 390 ALVSLRQQLDDLR---ALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQS 446
+ L Q ++ R A +L KLQS K++ E E++ N A ++ +
Sbjct: 1895 RVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE---EAEQQANTNLAKYRKAQHE 1951
Query: 447 EKDLVKQAKTLNSAANKL 464
D ++A + ANKL
Sbjct: 1952 LDDAEERADMAETQANKL 1969
Score = 34.7 bits (78), Expect = 0.19
Identities = 37/178 (20%), Positives = 81/178 (45%), Gaps = 31/178 (17%)
Query: 272 RHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGP 331
R L + +AK LE+++ +T+E N+ + LQ E
Sbjct: 906 RGLRGALAAAEAKRQELEETHVSITQE---KNDLALQLQAE------------------- 943
Query: 332 KQDRTAEGQALSEARKHLKEETQLRLDVE-KELEMQISMRQEMELAMKMLEKDVCEKQDA 390
QD A+ +E R HL +++++L+ + KEL ++ +E+ + + + +D
Sbjct: 944 -QDNLAD----AEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKL---EDE 995
Query: 391 LVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEK 448
L++ +DDL+ + + Q+++ VK +E + L+E ++ K L+++ +
Sbjct: 996 CTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053
Score = 29.3 bits (64), Expect = 8.0
Identities = 47/242 (19%), Positives = 99/242 (40%), Gaps = 24/242 (9%)
Query: 250 GTEGDGQITAIL-DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIIT 308
G + + ++ A L +Q +E L A + L+A ++ E+S +EL A R+
Sbjct: 1705 GRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNL 1764
Query: 309 L--------------QEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEE-T 353
L + ++ ++ E + R+ ++ + A A A + KE+ T
Sbjct: 1765 LHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDT 1824
Query: 354 QLRLDVEKEL------EMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHE 407
L+ K+ E+Q + + + A++ +K V + + + L +L D KH
Sbjct: 1825 SAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAEL-DAEQKKHA 1883
Query: 408 LAFK-LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIP 466
A K ++ + VK+ + + +M + +L+ K +Q + AN +
Sbjct: 1884 EALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLA 1943
Query: 467 KH 468
K+
Sbjct: 1944 KY 1945
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 55.8 bits (133), Expect = 8e-08
Identities = 47/180 (26%), Positives = 93/180 (51%), Gaps = 8/180 (4%)
Query: 281 LQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT--AE 338
LQ K + L++ KLT+ N ++ ++E+E+ ++ + LE K KQD++ AE
Sbjct: 258 LQEKDEMLQELEKKLTQ----VQNSLLKKEKELEK-QQCMATELEMTVKEAKQDKSKEAE 312
Query: 339 GQALSEARKHLKEETQLRLDVEKELEMQISM-RQEMELAMKMLEKDVCEKQDALVSLRQQ 397
+AL + LK + E+ Q + ++E LA LE + Q L+ +Q+
Sbjct: 313 CKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQK 372
Query: 398 LDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTL 457
D ++ L+ EL + S + K+++ R+EE + +++ +++LE S+K+ + KT+
Sbjct: 373 ADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTV 432
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/220 (25%), Positives = 98/220 (44%), Gaps = 18/220 (8%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTE-ELAVANNRIITLQE-EMERVKEE 319
++ ++EL + L N+L K LEK TE E+ V + +E E + ++ E
Sbjct: 260 EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE 319
Query: 320 SSYILESNRKGPKQDRTAEGQAL------SEARKHLKEETQLRLDVEKELEMQ-ISMRQE 372
+ S + +Q+R A QA + A HL E+TQ +L L+ Q QE
Sbjct: 320 VQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL-EDTQRKLQKGLLLDKQKADTIQE 378
Query: 373 MELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEK 432
++ ++ML+K+ + S R+++++L E KL++SD +Q + + + K
Sbjct: 379 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK 438
Query: 433 TNQMAATIKQLEQS--------EKDLVKQAKTLNSAANKL 464
N M IK + E+DL + K L +L
Sbjct: 439 MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQL 478
Score = 45.8 bits (107), Expect = 8e-05
Identities = 44/191 (23%), Positives = 92/191 (48%), Gaps = 13/191 (6%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
V E + +N ++ ++ + KL E+L A + +E++++ KE ++E
Sbjct: 432 VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK-LMEG 490
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQ-LRLDVE---KELEMQISMRQEMELAMKMLEK 382
+ +Q+ + + L E + L+EE + LR +++ +LE ++ + ++ L K
Sbjct: 491 ELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNK 550
Query: 383 DVCEKQDALVSLRQQLDD-LRALKHELAFKLQS------SDLGVKQKSELNSRLEEKTNQ 435
++ ++++L+SL+ QLD L+ KH L + S + +L L EK N
Sbjct: 551 EIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL-EKLNH 609
Query: 436 MAATIKQLEQS 446
+ + K L+QS
Sbjct: 610 VTSETKSLQQS 620
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 55.8 bits (133), Expect = 8e-08
Identities = 47/180 (26%), Positives = 93/180 (51%), Gaps = 8/180 (4%)
Query: 281 LQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT--AE 338
LQ K + L++ KLT+ N ++ ++E+E+ ++ + LE K KQD++ AE
Sbjct: 403 LQEKDEMLQELEKKLTQ----VQNSLLKKEKELEK-QQCMATELEMTVKEAKQDKSKEAE 457
Query: 339 GQALSEARKHLKEETQLRLDVEKELEMQISM-RQEMELAMKMLEKDVCEKQDALVSLRQQ 397
+AL + LK + E+ Q + ++E LA LE + Q L+ +Q+
Sbjct: 458 CKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQK 517
Query: 398 LDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTL 457
D ++ L+ EL + S + K+++ R+EE + +++ +++LE S+K+ + KT+
Sbjct: 518 ADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTV 577
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/220 (25%), Positives = 98/220 (44%), Gaps = 18/220 (8%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTE-ELAVANNRIITLQE-EMERVKEE 319
++ ++EL + L N+L K LEK TE E+ V + +E E + ++ E
Sbjct: 405 EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE 464
Query: 320 SSYILESNRKGPKQDRTAEGQAL------SEARKHLKEETQLRLDVEKELEMQ-ISMRQE 372
+ S + +Q+R A QA + A HL E+TQ +L L+ Q QE
Sbjct: 465 VQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL-EDTQRKLQKGLLLDKQKADTIQE 523
Query: 373 MELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEK 432
++ ++ML+K+ + S R+++++L E KL++SD +Q + + + K
Sbjct: 524 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK 583
Query: 433 TNQMAATIKQLEQS--------EKDLVKQAKTLNSAANKL 464
N M IK + E+DL + K L +L
Sbjct: 584 MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQL 623
Score = 45.8 bits (107), Expect = 8e-05
Identities = 44/191 (23%), Positives = 92/191 (48%), Gaps = 13/191 (6%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
V E + +N ++ ++ + KL E+L A + +E++++ KE ++E
Sbjct: 577 VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK-LMEG 635
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQ-LRLDVE---KELEMQISMRQEMELAMKMLEK 382
+ +Q+ + + L E + L+EE + LR +++ +LE ++ + ++ L K
Sbjct: 636 ELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNK 695
Query: 383 DVCEKQDALVSLRQQLDD-LRALKHELAFKLQS------SDLGVKQKSELNSRLEEKTNQ 435
++ ++++L+SL+ QLD L+ KH L + S + +L L EK N
Sbjct: 696 EIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL-EKLNH 754
Query: 436 MAATIKQLEQS 446
+ + K L+QS
Sbjct: 755 VTSETKSLQQS 765
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 55.8 bits (133), Expect = 8e-08
Identities = 47/203 (23%), Positives = 96/203 (47%), Gaps = 16/203 (7%)
Query: 268 EELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRIITLQEEM------- 313
EE+N L A L+ + +D LE + K+ +E N++ L EEM
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Query: 314 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 373
++ +E + E++++ + E + S ++ +K E Q+ D+E LE + +R ++
Sbjct: 992 AKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD-DLEGSLEQEKKVRMDL 1050
Query: 374 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKT 433
E A + LE D+ Q++++ L L + F + + ++ + L +L++K
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110
Query: 434 NQMAATIKQLEQS-EKDLVKQAK 455
+ A I++LE+ E + +AK
Sbjct: 1111 KENQARIEELEEELEAERTARAK 1133
Score = 44.3 bits (103), Expect = 2e-04
Identities = 43/197 (21%), Positives = 93/197 (47%), Gaps = 18/197 (9%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI-------ITLQEEMERVKEE 319
VE N L A + L+A V+ E+S +EL + R+ +L + ++++ +
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESD 1735
Query: 320 SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQI---SMRQEMELA 376
+ + + ++ R AE +A+K + + + +++KE + M++ ME
Sbjct: 1736 LTQLQSEVEEAVQECRNAE----EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1791
Query: 377 MKMLEKDVCE-KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQ 435
+K L+ + E +Q AL ++QL L A EL +L++ K+ +E + + +
Sbjct: 1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQ---KRNAESVKGMRKSERR 1848
Query: 436 MAATIKQLEQSEKDLVK 452
+ Q E+ +K+L++
Sbjct: 1849 IKELTYQTEEDKKNLLR 1865
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/248 (19%), Positives = 105/248 (42%), Gaps = 47/248 (18%)
Query: 260 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEE 319
I+ K +E+++R L N + K++ ++S T + A ++ T E+ R EE
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KLQTENGELARQLEE 1295
Query: 320 SSYILESNRKGP----------KQDRTAEGQA---LSEA-----------RKHLKEETQL 355
++ +G K+ EG+A L+ A R+ +EET+
Sbjct: 1296 KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
Query: 356 RLDVEKELEMQ---------------ISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDD 400
+ ++++ L I +E+E A K L + + + ++A+ ++ +
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 401 LRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQ----MAATIKQLEQSEKDLVKQAKT 456
L KH L +++ + V++ + + L++K +A ++ E+S+ +L K
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 457 LNSAANKL 464
S + +L
Sbjct: 1476 ARSLSTEL 1483
Score = 39.7 bits (91), Expect = 0.006
Identities = 40/185 (21%), Positives = 79/185 (42%), Gaps = 13/185 (7%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E++ + L LQ+ ALE++ L E +I+ Q E ++K E L
Sbjct: 1528 LEKVRKQLEVEKLELQS---ALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1580
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQEMELAMKMLEKD 383
+ +Q + + + + L ET+ R L V+K++E ++ EME+ + +
Sbjct: 1581 KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN---EMEIQLSHANRM 1637
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 443
E Q + SL+ L D + + + N+ L+ + ++ A ++Q
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Query: 444 EQSEK 448
E+S K
Sbjct: 1698 ERSRK 1702
Score = 37.7 bits (86), Expect = 0.023
Identities = 54/264 (20%), Positives = 108/264 (40%), Gaps = 82/264 (31%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDA-------LEKSNTKLTEELAVANNRIITLQEEM- 313
D+ N + + L V++L+ ++ LE++ KL +L + I+ L+ +
Sbjct: 1017 DKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKL 1076
Query: 314 ---ERVKEESSYILESNRKGPKQDRTAEGQALS-EARKHLKEETQLRLDVEKELEM---- 365
E++K++ I + N K + Q L+ + +K LKE ++E+ELE
Sbjct: 1077 QLEEKLKKKEFDINQQNSK------IEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 366 -------------------------------QISMRQEMELAMKMLEKDVCE-------- 386
QI M ++ E + + +D+ E
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1190
Query: 387 -------KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAAT 439
D++ L +Q+D+L+ +K +L K+KSE L++ T+ M
Sbjct: 1191 AAALRKKHADSVAELGEQIDNLQRVKQKLE----------KEKSEFKLELDDVTSNM--- 1237
Query: 440 IKQLEQSEKDLVKQAKTLNSAANK 463
+Q+ +++ +L K ++TL AN+
Sbjct: 1238 -EQIIKAKANLEKVSRTLEDQANE 1260
Score = 34.3 bits (77), Expect = 0.25
Identities = 38/159 (23%), Positives = 68/159 (42%), Gaps = 33/159 (20%)
Query: 310 QEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISM 369
++EM +KEE I E+ K SEAR+ EE + L EK ++Q+ +
Sbjct: 848 EKEMATMKEEFGRIKETLEK-------------SEARRKELEEKMVSLLQEKN-DLQLQV 893
Query: 370 RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRL 429
+ E QD L ++ D L K +L K++ + ++ + E+N+ L
Sbjct: 894 QAE---------------QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAEL 938
Query: 430 EEKTNQM----AATIKQLEQSEKDLVKQAKTLNSAANKL 464
K ++ + K ++ E L K K ++ NK+
Sbjct: 939 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 977
Score = 32.0 bits (71), Expect = 1.2
Identities = 33/181 (18%), Positives = 78/181 (43%), Gaps = 19/181 (10%)
Query: 300 AVANNRIITLQEEMERVKE--ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRL 357
A + T++EE R+KE E S E+ RK ++ + Q ++ + ++ E
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKS---EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 358 DVEKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRA 403
D E+ + I + ++E +K + + + +++ D L++ +DDL
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 404 LKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANK 463
++ + +++ VK +E + L+E ++ K L+++ + + + N
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 464 L 464
L
Sbjct: 1022 L 1022
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/215 (24%), Positives = 101/215 (46%), Gaps = 21/215 (9%)
Query: 262 DQKNYVEELNRHLNATVNNLQA---KVDALEKSNTKLTEE---LAVANNRIITLQEEMER 315
++ +++E+ N L + NL+ K++ALE+ N++L E L + L ++E
Sbjct: 632 NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES 691
Query: 316 VKEESSYILESN---RKGPKQDRTA---------EGQALSEARKHLKEETQLRLDVEKEL 363
+++E+S + E N R+ + + A E + L ++ LK+ +L K+
Sbjct: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Query: 364 EMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKS 423
E Q +++ + L+K + + L +L DL L L+ + K+
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 424 EL---NSRLEEKTNQMAATIKQLEQSEKDLVKQAK 455
+L N LE++T+Q+ KQLE+ K L +QA+
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 18/209 (8%)
Query: 263 QKNYVEELNRHLNATVNNL--------QAKVDALEKSNTKLTEELAVANNRIITLQEEME 314
Q +E+ N HLN TV++L +A+V +EK N L E + ++++ ++ E
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 315 RVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEME 374
++K+E + E + + L HL++E +L L++ + +E
Sbjct: 612 QIKKELEHYKEKGER---------AEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
LE++ + + L S + L +L+ E + +L +L +++ E K
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENS-QLDEENLELRRNVESLKCASMKMA 721
Query: 435 QMAATIKQLEQSEKDLVKQAKTLNSAANK 463
Q+ K+LE ++ L K + L ++ K
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKK 750
Score = 46.2 bits (108), Expect = 6e-05
Identities = 53/221 (23%), Positives = 106/221 (47%), Gaps = 25/221 (11%)
Query: 256 QITAILDQKNYVEELNRHLNATVN---NLQAKVDALEKSNTKLTEE----------LAVA 302
+I A+ + + +E NR L T++ NL ++++LEK N++L EE L A
Sbjct: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 303 NNRIITLQ---EEMERVKEESSYILESNRKGPKQDRTAEG--QALSEARKHLKEETQLRL 357
+ ++ LQ +E+E KE+ LE + K+ E Q L + L++ +
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--- 773
Query: 358 DVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDL 417
+ K+++ S Q++E+ + L+K++ E + + L Q + ++L+ E + +
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS----QLEK 829
Query: 418 GVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLN 458
KQ + N RL ++ T+++ +L K+ KTL+
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/217 (20%), Positives = 92/217 (42%), Gaps = 25/217 (11%)
Query: 269 ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR 328
E +HL+ + + +AK+ L + + TE+L + ++ E++R+++E+ +L R
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 329 --------------KGPKQDRTAEGQALSEARKH-----------LKEETQLRLDVEKEL 363
K + D+ + + R H LKE+ Q+ L+ + L
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 364 EMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKS 423
E Q+ + + LEK+ + + L + + D R EL + + ++ KQ
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 424 ELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSA 460
+ + L + Q++ T + E +K L + L S+
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Score = 38.1 bits (87), Expect = 0.017
Identities = 51/219 (23%), Positives = 92/219 (42%), Gaps = 21/219 (9%)
Query: 259 AILDQKNYVEELNRHLNATVNNLQAKVDALEKSNT-------KLTEELAVANNRIITLQE 311
A+ Q +E N +L A + LQ + +L++ NT KL E + N++ +L
Sbjct: 1064 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123
Query: 312 EMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ 371
+ ++ + S + N K+ + S + H K E L E E IS
Sbjct: 1124 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL-LHERQASEYESLISKHG 1182
Query: 372 EMELAMKMLE---KDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSR 428
++ A K LE +D+ ++ + L+ + QL+DL E K++ + ++ K+
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL-----EKMLKVEQEKMLLENKNHETVA 1237
Query: 429 LEEK-----TNQMAATIKQLEQSEKDLVKQAKTLNSAAN 462
E K +++ T QL + + L K L S N
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1276
Score = 32.7 bits (73), Expect = 0.73
Identities = 48/208 (23%), Positives = 92/208 (44%), Gaps = 24/208 (11%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEE---LAVANNRIIT----LQEEME 314
D+ + +E+ N L A +++++ + D K +L EE L +A + + L E+E
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
Query: 315 RVKEESSYILESNRK--GPKQDRTAEGQALS---EARKHLKEETQLRLDVEKELEMQISM 369
++ S + E+ +K G + + + L E + K +LR V+ +E S
Sbjct: 435 QISRTSE-LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS-VEGNASK 492
Query: 370 RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRL 429
+ME + L K V ++ +V +Q L + + L +L +K+K++L +
Sbjct: 493 ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL----------MKEKAQLEKTI 542
Query: 430 EEKTNQMAATIKQLEQSEKDLVKQAKTL 457
E IK LEQ + L + +L
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSL 570
Score = 31.2 bits (69), Expect = 2.1
Identities = 37/182 (20%), Positives = 68/182 (37%), Gaps = 18/182 (9%)
Query: 251 TEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQ 310
T+ + Q + K +EE NRHL + L + L + N + + V + I
Sbjct: 1304 TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
Query: 311 EEMERVKEESSYILESNRK--GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQIS 368
E+ R KE+ + K P R + RK +K + + + +K L + +
Sbjct: 1364 NELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPT 1423
Query: 369 MRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSR 428
E +++ +D QD+ L+D LG K+ S +N
Sbjct: 1424 RSDSSEGFLQLPHQD---SQDSSSVGSNSLED-------------GQTLGTKKSSTMNDL 1467
Query: 429 LE 430
++
Sbjct: 1468 VQ 1469
Score = 30.4 bits (67), Expect = 3.6
Identities = 24/106 (22%), Positives = 48/106 (45%), Gaps = 6/106 (5%)
Query: 262 DQKNYVEELNR------HLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
D KN LN L A + L+ + L+ ++TKL + + + L+EE
Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Query: 316 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEK 361
+ ++ ++ NR +Q+ ++ E R+++ + +LR EK
Sbjct: 1327 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
Score = 29.6 bits (65), Expect = 6.1
Identities = 36/197 (18%), Positives = 89/197 (45%), Gaps = 22/197 (11%)
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEM--ERVKEE------SSYILESNRKGPKQDR 335
++ LEK N +L + + ++TL+E++ E++K + E + G ++R
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
Query: 336 TAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAM-------KMLEKDVCEKQ 388
+ ++ ++ E++L ++K LE++ +E + + L +++ +
Sbjct: 942 LLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1001
Query: 389 DALVSLRQQLDDLRALKHELAFK------LQSSDLGVKQKSELNSRLEEKTNQMAATIKQ 442
+L+Q+ D+ R ++ + S ++ ++ RL E + AT++
Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE-VERNNATLQA 1060
Query: 443 LEQSEKDLVKQAKTLNS 459
+Q+ K +KQ +T N+
Sbjct: 1061 EKQALKTQLKQLETQNN 1077
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,961,319
Number of Sequences: 37866
Number of extensions: 682621
Number of successful extensions: 6122
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 658
Number of HSP's that attempted gapping in prelim test: 3298
Number of HSP's gapped (non-prelim): 2524
length of query: 469
length of database: 18,247,518
effective HSP length: 106
effective length of query: 363
effective length of database: 14,233,722
effective search space: 5166841086
effective search space used: 5166841086
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.