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Search of human proteins with 7657526
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo
sapiens]
(745 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 1508 0.0
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 1152 0.0
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1110 0.0
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1108 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1087 0.0
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1082 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 542 e-154
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 520 e-147
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 520 e-147
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 417 e-116
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 372 e-103
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 357 3e-98
gi|62241015 AKT1 kinase [Homo sapiens] 275 9e-74
gi|62241013 AKT1 kinase [Homo sapiens] 275 9e-74
gi|62241011 AKT1 kinase [Homo sapiens] 275 9e-74
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 273 4e-73
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 273 4e-73
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 273 6e-73
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 273 6e-73
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 272 9e-73
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 272 9e-73
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 272 9e-73
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 272 9e-73
gi|4502023 AKT2 kinase [Homo sapiens] 270 3e-72
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 269 8e-72
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 269 8e-72
gi|4506067 protein kinase C, alpha [Homo sapiens] 249 9e-66
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 248 1e-65
gi|28557781 protein kinase C, eta [Homo sapiens] 245 9e-65
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 244 3e-64
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 1508 bits (3903), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 1 MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH 60
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH
Sbjct: 1 MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH 60
Query: 61 VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT 120
VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT
Sbjct: 61 VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT 120
Query: 121 KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA 180
KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA
Sbjct: 121 KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA 180
Query: 181 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM 240
ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM
Sbjct: 181 ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM 240
Query: 241 APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA 300
APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA
Sbjct: 241 APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA 300
Query: 301 QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF 360
QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF
Sbjct: 301 QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF 360
Query: 361 DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA 420
DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA
Sbjct: 361 DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA 420
Query: 421 QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI 480
QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI
Sbjct: 421 QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI 480
Query: 481 ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV 540
ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV
Sbjct: 481 ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV 540
Query: 541 HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD 600
HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD
Sbjct: 541 HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD 600
Query: 601 AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL 660
AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL
Sbjct: 601 AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL 660
Query: 661 SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ 720
SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ
Sbjct: 661 SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ 720
Query: 721 PVLEPVAASSLAQRRSMKKRTSTGL 745
PVLEPVAASSLAQRRSMKKRTSTGL
Sbjct: 721 PVLEPVAASSLAQRRSMKKRTSTGL 745
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 1152 bits (2981), Expect = 0.0
Identities = 574/746 (76%), Positives = 647/746 (86%), Gaps = 8/746 (1%)
Query: 2 LPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV 61
+P A +PW + M V S S NG +++DEPM E E + +E +KEI ITHHV
Sbjct: 1 MPLAQLADPWQK-MAVES---PSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHV 56
Query: 62 KEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK 121
KEG+EKADP+QFELLKVLGQGSFGKVFLV+K +G DA QLYAMKVLKKA+LKVRDRVRTK
Sbjct: 57 KEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK 116
Query: 122 MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAE 181
MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD+FTRLSKEV+FTEEDVKFYLAE
Sbjct: 117 MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 176
Query: 182 LALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMA 241
LALALDHLH LGI+YRDLKPENILLDE GHIKLTDFGLSKES+D EKKAYSFCGTVEYMA
Sbjct: 177 LALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMA 236
Query: 242 PEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQ 301
PEVVNRRGH+QSADWWS+GVLMFEMLTGTLPFQGKDR ETM MILKAKLGMPQFLS EAQ
Sbjct: 237 PEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQ 296
Query: 302 SLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFC 359
SLLRMLFKRNPANRLG+ +GVEEIKRH FF+ IDW+KLY+RE+ PPFKPA+G+P+DTF
Sbjct: 297 SLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFY 356
Query: 360 FDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNA 419
FDPEFTAKTPKDSPG+P SANAHQLF+GFSFVA + +E + + + + Q++ N+
Sbjct: 357 FDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSI-VQQLHRNS 415
Query: 420 AQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPN 479
QF + YE+KEDIGVGSYSVCKRCIH TNMEFAVKIIDKSKRDP+EEIEIL+RYGQHPN
Sbjct: 416 IQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPN 475
Query: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 539
IITLKDV+DDG+YVY+VT+LMKGGELLD+IL+QK FSEREAS +L+ I+KTV+YLH QGV
Sbjct: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 535
Query: 540 VHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGY 599
VHRDLKPSNILY+DES + +SIRICDFGFAKQLR ENGLL+TPCYTANFVAPEVL +QGY
Sbjct: 536 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 595
Query: 600 DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDL 659
DAACDIWSLGVL YTML GYTPFANGP+DTPEEIL RIG+GKFSLSGG W+++SD AKDL
Sbjct: 596 DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDL 655
Query: 660 LSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTF 719
+S MLH+DPHQR TA +L+H WI H DQLP Q R D H+VKGAM ATYSAL ++
Sbjct: 656 VSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSAL-NRNQ 714
Query: 720 QPVLEPVAASSLAQRRSMKKRTSTGL 745
PVLEPV S+LAQRR +KK TST L
Sbjct: 715 SPVLEPVGRSTLAQRRGIKKITSTAL 740
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 1110 bits (2871), Expect = 0.0
Identities = 545/713 (76%), Positives = 623/713 (87%), Gaps = 6/713 (0%)
Query: 36 EPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTG 95
EP E A+ +EGVVKEI I+HHVKEG+EKADP+QFELLKVLGQGS+GKVFLVRK G
Sbjct: 32 EPTTEDTAEE--EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKG 89
Query: 96 PDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFL 155
DAGQLYAMKVLKKA+LKVRDRVR+KMERDIL EVNHPFIVKLHYAFQTEGKLYLILDFL
Sbjct: 90 SDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFL 149
Query: 156 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 215
RGGD+FTRLSKEV+FTEEDVKFYLAELALALDHLH LGI+YRDLKPENILLDE GHIK+T
Sbjct: 150 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKIT 209
Query: 216 DFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQG 275
DFGLSKE++D +K+AYSFCGT+EYMAPEVVNRRGH+QSADWWS+GVLMFEMLTG+LPFQG
Sbjct: 210 DFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQG 269
Query: 276 KDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANI 333
KDR ETM +ILKAKLGMPQFLS EAQSLLR LFKRNP NRLG+ +GVEEIKRH FF I
Sbjct: 270 KDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329
Query: 334 DWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVAT 393
DW+ LY++E++PPFKPA G+P+DTF FDPEFTA+TP DSPG+P SANAH LF+GFSFVA+
Sbjct: 330 DWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 389
Query: 394 SIAEEYKITPITSANVLPIV-QINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEF 452
S+ +E + V PIV Q++GN F + YE+KEDIGVGSYSVCKRC+H T+ E+
Sbjct: 390 SLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEY 449
Query: 453 AVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQ 512
AVKIIDKSKRDPSEEIEIL+RYGQHPNIITLKDV+DDG++VYLV +LM+GGELLDRIL+Q
Sbjct: 450 AVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQ 509
Query: 513 KCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL 572
+ FSEREASD+L I+KT+DYLH QGVVHRDLKPSNILY DES S +SIR+CDFGFAKQL
Sbjct: 510 RYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQL 569
Query: 573 RGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEE 632
R NGLL+TPCYTANFVAPEVL +QGYDAACDIWSLG+L YTMLAG+TPFANGP+DTPEE
Sbjct: 570 RAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEE 629
Query: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPND 692
IL RIG+GK++LSGGNWD+ISD AKD++S MLH+DPHQR TA Q+LKH W+ +R+ L +
Sbjct: 630 ILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPN 689
Query: 693 QPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL 745
Q R DV H+VKGAM ATY AL P LEPV +S+LAQRR MK+ TST L
Sbjct: 690 QLSRQDV-HLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 741
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 1108 bits (2865), Expect = 0.0
Identities = 541/701 (77%), Positives = 618/701 (88%), Gaps = 4/701 (0%)
Query: 48 DEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL 107
+EGVVKEI I+HHVKEG+EKADP+QFELLKVLGQGS+GKVFLVRK G DAGQLYAMKVL
Sbjct: 34 EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL 93
Query: 108 KKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE 167
KKA+LKVRDRVR+KMERDIL EVNHPFIVKLHYAFQTEGKLYLILDFLRGGD+FTRLSKE
Sbjct: 94 KKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 153
Query: 168 VLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE 227
V+FTEEDVKFYLAELALALDHLH LGI+YRDLKPENILLDE GHIK+TDFGLSKE++D +
Sbjct: 154 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD 213
Query: 228 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILK 287
K+AYSFCGT+EYMAPEVVNRRGH+QSADWWS+GVLMFEMLTG+LPFQGKDR ETM +ILK
Sbjct: 214 KRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILK 273
Query: 288 AKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQP 345
AKLGMPQFLS EAQSLLR LFKRNP NRLG+ +GVEEIKRH FF IDW+ LY++E++P
Sbjct: 274 AKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKP 333
Query: 346 PFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPIT 405
PFKPA G+P+DTF FDPEFTA+TP DSPG+P SANAH LF+GFSFVA+S+ +E +
Sbjct: 334 PFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLH 393
Query: 406 SANVLPIV-QINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDP 464
V PIV Q++GN F + YE+KEDIGVGSYSVCKRC+H T+ E+AVKIIDKSKRDP
Sbjct: 394 KVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDP 453
Query: 465 SEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDIL 524
SEEIEIL+RYGQHPNIITLKDV+DDG++VYLV +LM+GGELLDRIL+Q+ FSEREASD+L
Sbjct: 454 SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVL 513
Query: 525 YVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY 584
I+KT+DYLH QGVVHRDLKPSNILY DES S +SIR+CDFGFAKQLR NGLL+TPCY
Sbjct: 514 CTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY 573
Query: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
TANFVAPEVL +QGYDAACDIWSLG+L YTMLAG+TPFANGP+DTPEEIL RIG+GK++L
Sbjct: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
Query: 645 SGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVK 704
SGGNWD+ISD AKD++S MLH+DPHQR TA Q+LKH W+ +R+ L +Q R DV H+VK
Sbjct: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDV-HLVK 692
Query: 705 GAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL 745
GAM ATY AL P LEPV +S+LAQRR MK+ TST L
Sbjct: 693 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 1087 bits (2811), Expect = 0.0
Identities = 541/748 (72%), Positives = 622/748 (83%), Gaps = 20/748 (2%)
Query: 2 LPFAPQDEPWDREMEVFS---GGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPIT 58
+P A EPW ME+ G +SGE GL+ DEGV+KEI IT
Sbjct: 1 MPLAQLKEPWPL-MELVPLDPENGQTSGEEAGLQ------------PSKDEGVLKEISIT 47
Query: 59 HHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRV 118
HHVK G EKADP+ FELLKVLGQGSFGKVFLVRK T PD+G LYAMKVLKKA+LKVRDRV
Sbjct: 48 HHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRV 107
Query: 119 RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFY 178
RTKMERDIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGD+FTRLSKEV+FTEEDVKFY
Sbjct: 108 RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFY 167
Query: 179 LAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVE 238
LAELAL LDHLH LGI+YRDLKPENILLDE GHIKLTDFGLSKE++D EKKAYSFCGTVE
Sbjct: 168 LAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVE 227
Query: 239 YMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSA 298
YMAPEVVNR+GHS SADWWSYGVLMFEMLTG+LPFQGKDR ETM +ILKAKLGMPQFLS
Sbjct: 228 YMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLST 287
Query: 299 EAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDD 356
EAQSLLR LFKRNPANRLGS +G EEIKRH+F++ IDW+KLY+RE++PPFKPA +PDD
Sbjct: 288 EAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDD 347
Query: 357 TFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIV-QI 415
TF FD EFT++TPKDSPG+P SA AHQLF+GFSFVAT + E+ A + +V Q+
Sbjct: 348 TFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQL 407
Query: 416 NGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYG 475
+G F + Y +KE IGVGSYS CKRC+H TNME+AVK+IDKSKRDPSEEIEIL+RYG
Sbjct: 408 HGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYG 467
Query: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
QHPNIITLKDV+DDG++VYLVT+LM+GGELLD+IL+QK FSEREAS +L+ I KTV+YLH
Sbjct: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
Query: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLM 595
QGVVHRDLKPSNILY+DES + + +RICDFGFAKQLR ENGLL+TPCYTANFVAPEVL
Sbjct: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
Query: 596 QQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDG 655
+QGYD CDIWSLG+L YTMLAGYTPFANGP+DTPEEIL RIG+GKF+LSGGNW+ +S+
Sbjct: 588 RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSET 647
Query: 656 AKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALT 715
AKDL+S MLH+DPHQR TA+Q+L+H W+T +D+LP Q D+ +VKGAM ATYSAL
Sbjct: 648 AKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLVKGAMAATYSALN 706
Query: 716 HKTFQPVLEPVAASSLAQRRSMKKRTST 743
P L+P+ +S LAQRR K ++T
Sbjct: 707 SSKPTPQLKPIESSILAQRRVRKLPSTT 734
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 1082 bits (2799), Expect = 0.0
Identities = 528/699 (75%), Positives = 605/699 (86%), Gaps = 4/699 (0%)
Query: 48 DEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL 107
DEGV+KEI ITHHVK G EKADP+ FELLKVLGQGSFGKVFLVRK T PD+G LYAMKVL
Sbjct: 46 DEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL 105
Query: 108 KKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE 167
KKA+LKVRDRVRTKMERDIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGD+FTRLSKE
Sbjct: 106 KKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 165
Query: 168 VLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQE 227
V+FTEEDVKFYLAELAL LDHLH LGI+YRDLKPENILLDE GHIKLTDFGLSKE++D E
Sbjct: 166 VMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHE 225
Query: 228 KKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILK 287
KKAYSFCGTVEYMAPEVVNR+GHS SADWWSYGVLMFEMLTG+LPFQGKDR ETM +ILK
Sbjct: 226 KKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILK 285
Query: 288 AKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQP 345
AKLGMPQFLS EAQSLLR LFKRNPANRLGS +G EEIKRH+F++ IDW+KLY+RE++P
Sbjct: 286 AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKP 345
Query: 346 PFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPIT 405
PFKPA +PDDTF FD EFT++TPKDSPG+P SA AHQLF+GFSFVAT + E+
Sbjct: 346 PFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAP 405
Query: 406 SANVLPIV-QINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDP 464
A + +V Q++G F + Y +KE IGVGSYS CKRC+H TNME+AVK+IDKSKRDP
Sbjct: 406 QAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP 465
Query: 465 SEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDIL 524
SEEIEIL+RYGQHPNIITLKDV+DDG++VYLVT+LM+GGELLD+IL+QK FSEREAS +L
Sbjct: 466 SEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVL 525
Query: 525 YVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCY 584
+ I KTV+YLH QGVVHRDLKPSNILY+DES + + +RICDFGFAKQLR ENGLL+TPCY
Sbjct: 526 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY 585
Query: 585 TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSL 644
TANFVAPEVL +QGYD CDIWSLG+L YTMLAGYTPFANGP+DTPEEIL RIG+GKF+L
Sbjct: 586 TANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 645
Query: 645 SGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVK 704
SGGNW+ +S+ AKDL+S MLH+DPHQR TA+Q+L+H W+T +D+LP Q D+ +VK
Sbjct: 646 SGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLVK 704
Query: 705 GAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTST 743
GAM ATYSAL P L+P+ +S LAQRR K ++T
Sbjct: 705 GAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTT 743
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 542 bits (1396), Expect = e-154
Identities = 319/714 (44%), Positives = 439/714 (61%), Gaps = 40/714 (5%)
Query: 66 EKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTKME 123
EK FELLKVLG G++GKVFLVRK +G D G+LYAMKVLKKA++ K + T+ E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 124 RDILVEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 182
R +L + PF+V LHYAFQTE KL+LILD++ GG++FT LS+ FTE +V+ Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 183 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV-DQEKKAYSFCGTVEYMA 241
LAL+HLH+LGI+YRD+K ENILLD GH+ LTDFGLSKE V D+ ++AYSFCGT+EYMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 242 PEVV--NRRGHSQSADWWSYGVLMFEMLTGTLPF----QGKDRNETMNMILKAKLGMPQF 295
P++V GH ++ DWWS GVLM+E+LTG PF + + E ILK++ PQ
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
Query: 296 LSAEAQSLLRMLFKRNPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
+SA A+ L++ L ++P RL G +EIK HLFF I+WD L ++V PFKP
Sbjct: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
Query: 354 PDDTFCFDPEFTAKTPKDSP-GLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPI 412
D F EFT P SP LP S + +LF+G+SFVA SI + I
Sbjct: 342 ELDVSNFAEEFTEMDPTYSPAALPQS--SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMG 399
Query: 413 VQING--NAAQ--------FGEVYEL---KEDIGVGSYSVCKRCIHATTNMEFAVKIIDK 459
V+ G N A+ F + Y+L + +G GS+S+C++C+H +N FAVKII K
Sbjct: 400 VERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISK 459
Query: 460 -SKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSER 518
+ + +EI L HPNI+ L +VF D + +LV +L+ GGEL +RI K+K FSE
Sbjct: 460 RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSET 519
Query: 519 EASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGL 578
EAS I+ + V ++H GVVHRDLKP N+L+ DE+ + + I+I DFGFA+ +N
Sbjct: 520 EASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQP 578
Query: 579 LLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPND----TPEEIL 634
L TPC+T ++ APE+L Q GYD +CD+WSLGV+ YTML+G PF + + EI+
Sbjct: 579 LKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIM 638
Query: 635 LRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQP 694
+I G FS G W N+S AKDL+ +L +DP++R + + W+ QL ++
Sbjct: 639 KKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPL 698
Query: 695 KRNDV----SHVVKGAMVATYSALT-HKTFQPVLEPVAASSLAQRRSMKKRTST 743
D+ V + AT+ A +K L+ V + LA+RR MKK TST
Sbjct: 699 MTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TST 751
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 520 bits (1340), Expect = e-147
Identities = 309/736 (41%), Positives = 435/736 (59%), Gaps = 36/736 (4%)
Query: 39 EEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDA 98
+E + +SC E + E +T H EK FELLKVLG G++GKVFLVRK G DA
Sbjct: 3 DEDDDESCAVELRITEANLTGHE----EKVSVENFELLKVLGTGAYGKVFLVRKAGGHDA 58
Query: 99 GQLYAMKVLKKASLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILDFL 155
G+LYAMKVL+KA+L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++
Sbjct: 59 GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYV 118
Query: 156 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 215
GG++FT L + F E +V+ Y E+ LAL+HLH+LGI+YRDLK EN+LLD GHI LT
Sbjct: 119 SGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLT 178
Query: 216 DFGLSKESVDQEK-KAYSFCGTVEYMAPEVV-NRRGHSQSADWWSYGVLMFEMLTGTLPF 273
DFGLSKE + +EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG PF
Sbjct: 179 DFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Query: 274 ----QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRH 327
+ + E ILK P + AQ LL+ L ++P RLG+ +G +E++ H
Sbjct: 239 TLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNH 298
Query: 328 LFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKG 387
FF +DW L R++ PF+P D F EFT P SP ++F+G
Sbjct: 299 PFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQG 358
Query: 388 FSFVATSIAEEYKITPITSANVLP-IVQINGNAA----QFGEVYEL---KEDIGVGSYSV 439
+SFVA SI ++ +T P G AA + YEL + +G GS+SV
Sbjct: 359 YSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSFSV 418
Query: 440 CKRCIHATTNMEFAVKIIDKS-KRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTD 498
C+RC + EFAVKI+ + + + E+ L HPN++ L +V D + YLV +
Sbjct: 419 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 478
Query: 499 LMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-GVVHRDLKPSNILYMDESAS 557
L++GGELL+ I K++ FSE EAS IL + V ++H + GVVHRDLKP NILY D++
Sbjct: 479 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 538
Query: 558 ADSIRICDFGFAKQLRGENGL-LLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTML 616
A ++I DFGFA+ G+ + TPC+T + APE+L QQGYD +CD+WSLGV+ Y ML
Sbjct: 539 A-PVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMML 597
Query: 617 AGYTPF----ANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRY 672
+G PF G EI+ +I G+FSL G W +S+ AK+L+ +L +DP +R
Sbjct: 598 SGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 657
Query: 673 TAEQILKHSWITHRDQLPNDQPKRNDV----SHVVKGAMVATYSALTH-KTFQPVLEPVA 727
E + SW+ + + DV V+ + AT+ A K L+ V
Sbjct: 658 KLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVE 717
Query: 728 ASSLAQRRSMKKRTST 743
+ LA+RR K R++T
Sbjct: 718 NAPLAKRRKQKLRSAT 733
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 520 bits (1340), Expect = e-147
Identities = 310/742 (41%), Positives = 436/742 (58%), Gaps = 42/742 (5%)
Query: 39 EEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDA 98
+E + +SC E + E +T H EK FELLKVLG G++GKVFLVRK G DA
Sbjct: 3 DEDDDESCAVELRITEANLTGHE----EKVSVENFELLKVLGTGAYGKVFLVRKAGGHDA 58
Query: 99 GQLYAMKVLKKASLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILDFL 155
G+LYAMKVL+KA+L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++
Sbjct: 59 GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYV 118
Query: 156 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 215
GG++FT L + F E +V+ Y E+ LAL+HLH+LGI+YRDLK EN+LLD GHI LT
Sbjct: 119 SGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLT 178
Query: 216 DFGLSKESVDQEK-KAYSFCGTVEYMAPEVV-NRRGHSQSADWWSYGVLMFEMLTGTLPF 273
DFGLSKE + +EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG PF
Sbjct: 179 DFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
Query: 274 ----QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRH 327
+ + E ILK P + AQ LL+ L ++P RLG+ +G +E++ H
Sbjct: 239 TLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNH 298
Query: 328 LFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKG 387
FF +DW L R++ PF+P D F EFT P SP ++F+G
Sbjct: 299 PFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQG 358
Query: 388 FSFVATSIAEEYKITPITSANVLP-IVQINGNAA----------QFGEVYEL---KEDIG 433
+SFVA SI ++ +T P G AA F + YEL + +G
Sbjct: 359 YSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALG 418
Query: 434 VGSYSVCKRCIHATTNMEFAVKIIDKS-KRDPSEEIEILMRYGQHPNIITLKDVFDDGRY 492
GS+SVC+RC + EFAVKI+ + + + E+ L HPN++ L +V D +
Sbjct: 419 QGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLH 478
Query: 493 VYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-GVVHRDLKPSNILY 551
YLV +L++GGELL+ I K++ FSE EAS IL + V ++H + GVVHRDLKP NILY
Sbjct: 479 TYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILY 538
Query: 552 MDESASADSIRICDFGFAKQLRGENGL-LLTPCYTANFVAPEVLMQQGYDAACDIWSLGV 610
D++ A ++I DFGFA+ G+ + TPC+T + APE+L QQGYD +CD+WSLGV
Sbjct: 539 ADDTPGA-PVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGV 597
Query: 611 LFYTMLAGYTPF----ANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHM 666
+ Y ML+G PF G EI+ +I G+FSL G W +S+ AK+L+ +L +
Sbjct: 598 ILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTV 657
Query: 667 DPHQRYTAEQILKHSWITHRDQLPNDQPKRNDV----SHVVKGAMVATYSALTH-KTFQP 721
DP +R E + SW+ + + DV V+ + AT+ A K
Sbjct: 658 DPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGF 717
Query: 722 VLEPVAASSLAQRRSMKKRTST 743
L+ V + LA+RR K R++T
Sbjct: 718 FLKSVENAPLAKRRKQKLRSAT 739
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 417 bits (1071), Expect = e-116
Identities = 241/508 (47%), Positives = 323/508 (63%), Gaps = 29/508 (5%)
Query: 66 EKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASL--KVRDRVRTKME 123
EK FELLKVLG G++GKVFLVRK +G D G+LYAMKVLKKA++ K + T+ E
Sbjct: 42 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 101
Query: 124 RDILVEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAEL 182
R +L + PF+V LHYAFQTE KL+LILD++ GG++FT LS+ FTE +V+ Y+ E+
Sbjct: 102 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI 161
Query: 183 ALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV-DQEKKAYSFCGTVEYMA 241
LAL+HLH+LGI+YRD+K ENILLD GH+ LTDFGLSKE V D+ ++AYSFCGT+EYMA
Sbjct: 162 VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMA 221
Query: 242 PEVV--NRRGHSQSADWWSYGVLMFEMLTGTLPF----QGKDRNETMNMILKAKLGMPQF 295
P++V GH ++ DWWS GVLM+E+LTG PF + + E ILK++ PQ
Sbjct: 222 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQE 281
Query: 296 LSAEAQSLLRMLFKRNPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
+SA A+ L++ L ++P RL G +EIK HLFF I+WD L ++V PFKP
Sbjct: 282 MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRD 341
Query: 354 PDDTFCFDPEFTAKTPKDSP-GLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPI 412
D F EFT P SP LP S + +LF+G+SFVA SI + I
Sbjct: 342 ELDVSNFAEEFTEMDPTYSPAALPQS--SEKLFQGYSFVAPSILFKRNAAVIDPLQFHMG 399
Query: 413 VQING--NAAQ--------FGEVYEL---KEDIGVGSYSVCKRCIHATTNMEFAVKIIDK 459
V+ G N A+ F + Y+L + +G GS+S+C++C+H +N FAVKII K
Sbjct: 400 VERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISK 459
Query: 460 -SKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSER 518
+ + +EI L HPNI+ L +VF D + +LV +L+ GGEL +RI K+K FSE
Sbjct: 460 RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSET 519
Query: 519 EASDILYVISKTVDYLHCQGVVHRDLKP 546
EAS I+ + V ++H GVVHRDLKP
Sbjct: 520 EASYIMRKLVSAVSHMHDVGVVHRDLKP 547
Score = 106 bits (265), Expect = 7e-23
Identities = 85/298 (28%), Positives = 149/298 (50%), Gaps = 29/298 (9%)
Query: 404 ITSANVLPIVQINGNAAQFG-EVYELKEDIGVGSYS---VCKRCIHATTNMEFAVKIIDK 459
+T + L + G+A + G E +EL + +G G+Y + ++ T +A+K++ K
Sbjct: 26 LTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKK 85
Query: 460 S----KRDPSE----EIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILK 511
+ K +E E ++L Q P ++TL F ++L+ D + GGEL + +
Sbjct: 86 ATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQ 145
Query: 512 QKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQ 571
++ F+E E + I +++LH G+++RD+K NIL S + + DFG +K+
Sbjct: 146 RERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILL----DSNGHVVLTDFGLSKE 201
Query: 572 -LRGENGLLLTPCYTANFVAPEVLM--QQGYDAACDIWSLGVLFYTMLAGYTPF-ANGPN 627
+ E + C T ++AP+++ G+D A D WSLGVL Y +L G +PF +G
Sbjct: 202 FVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEK 261
Query: 628 DTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRY-----TAEQILKH 680
++ EI RI + +S AKDL+ +L DP +R A++I +H
Sbjct: 262 NSQAEISRRILKSEPPYP----QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEH 315
Score = 81.3 bits (199), Expect = 3e-15
Identities = 45/130 (34%), Positives = 75/130 (57%), Gaps = 15/130 (11%)
Query: 77 KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDI----LVEVNH 132
K LG+GSF + RK + Q +A+K++ K R+ +++I L E H
Sbjct: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCE-GH 478
Query: 133 PFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQL 192
P IVKLH F + +L+++ L GG++F R+ K+ F+E + + + +L A+ H+H +
Sbjct: 479 PNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 538
Query: 193 GIVYRDLKPE 202
G+V+RDLKPE
Sbjct: 539 GVVHRDLKPE 548
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 372 bits (955), Expect = e-103
Identities = 200/414 (48%), Positives = 272/414 (65%), Gaps = 17/414 (4%)
Query: 4 FAPQDEPWDREMEVFSGG-GASSGEVNGLKMVDEPMEEGEADSCHDEGVVK--EIPITH- 59
F P + DRE E +G + DE E G+ + D G V E+ + H
Sbjct: 10 FYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHC 69
Query: 60 --------HVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKAS 111
V G EK P FELL+VLG+G +GKVF VRK TG + G+++AMKVLKKA
Sbjct: 70 EKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAM 129
Query: 112 L--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL 169
+ +D TK ER+IL EV HPFIV L YAFQT GKLYLIL++L GG++F +L +E +
Sbjct: 130 IVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 189
Query: 170 FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKK 229
F E+ FYLAE+++AL HLHQ GI+YRDLKPENI+L+ GH+KLTDFGL KES+
Sbjct: 190 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV 249
Query: 230 AYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAK 289
++FCGT+EYMAPE++ R GH+++ DWWS G LM++MLTG PF G++R +T++ ILK K
Sbjct: 250 THTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK 309
Query: 290 LGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPF 347
L +P +L+ EA+ LL+ L KRN A+RLG+ E++ H FF +I+W++L R+V+PPF
Sbjct: 310 LNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPF 369
Query: 348 KPASGKPDDTFCFDPEFTAKTPKDSP-GLPASANAHQLFKGFSFVATSIAEEYK 400
KP +D FD +FT +TP DSP S +A+Q+F GF++VA S+ E K
Sbjct: 370 KPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVK 423
Score = 112 bits (279), Expect = 2e-24
Identities = 77/261 (29%), Positives = 130/261 (49%), Gaps = 21/261 (8%)
Query: 424 EVYELKEDIGVGSYSVC---KRCIHATTNMEFAVKIIDKSK--RDPSEEIEI-----LMR 473
E +EL +G G Y ++ A T FA+K++ K+ R+ + ++
Sbjct: 89 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 148
Query: 474 YGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDY 533
+HP I+ L F G +YL+ + + GGEL ++ ++ F E A L IS + +
Sbjct: 149 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH 208
Query: 534 LHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEV 593
LH +G+++RDLKP NI+ + +++ DFG K+ + + T C T ++APE+
Sbjct: 209 LHQKGIIYRDLKPENIMLNHQG----HVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEI 264
Query: 594 LMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNIS 653
LM+ G++ A D WSLG L Y ML G PF + ++ + +I K +L ++
Sbjct: 265 LMRSGHNRAVDWWSLGALMYDMLTGAPPFT---GENRKKTIDKILKCKLNLP----PYLT 317
Query: 654 DGAKDLLSHMLHMDPHQRYTA 674
A+DLL +L + R A
Sbjct: 318 QEARDLLKKLLKRNAASRLGA 338
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 357 bits (915), Expect = 3e-98
Identities = 180/370 (48%), Positives = 249/370 (67%), Gaps = 6/370 (1%)
Query: 37 PMEEGEADSCHDEGVVKEIPITH-HVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTG 95
P+ E A G +E+ +T V G E+ P FELL+VLG+G +GKVF VRK G
Sbjct: 30 PLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQG 89
Query: 96 PDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILD 153
+ G++YAMKVL+KA + +D T+ ER+IL V HPFIV+L YAFQT GKLYLIL+
Sbjct: 90 TNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILE 149
Query: 154 FLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIK 213
L GG++FT L +E +F E+ FYLAE+ LAL HLH GI+YRDLKPENI+L GHIK
Sbjct: 150 CLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIK 209
Query: 214 LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPF 273
LTDFGL KES+ + ++FCGT+EYMAPE++ R GH+++ DWWS G LM++MLTG+ PF
Sbjct: 210 LTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPF 269
Query: 274 QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFA 331
++R +TM+ I++ KL +P +L+ +A+ L++ KRNP+ R+G +++RH FF
Sbjct: 270 TAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFR 329
Query: 332 NIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPA-SANAHQLFKGFSF 390
+++WD L V PPF+P +D FD FT +TP DSP A S +A+Q F GF++
Sbjct: 330 HMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTY 389
Query: 391 VATSIAEEYK 400
VA S+ + K
Sbjct: 390 VAPSVLDSIK 399
Score = 117 bits (294), Expect = 3e-26
Identities = 82/276 (29%), Positives = 135/276 (48%), Gaps = 28/276 (10%)
Query: 426 YELKEDIGVGSYSVC---KRCIHATTNMEFAVKIIDKSK--RDPSEEIEI-----LMRYG 475
+EL +G G Y ++ +A+K++ K+K R+ + ++
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
+HP I+ L F G +YL+ + + GGEL + ++ F E A L I+ + +LH
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
Query: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLM 595
QG+++RDLKP NI+ +S I++ DFG K+ E + T C T ++APE+L+
Sbjct: 187 SQGIIYRDLKPENIML----SSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
Query: 596 QQGYDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEEILLRIGNGKFSLSGGNWDNISD 654
+ G++ A D WSLG L Y ML G PF A T ++I+ GK +L ++
Sbjct: 243 RSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKII----RGKLALP----PYLTP 294
Query: 655 GAKDLLSHMLHMDPHQRY-----TAEQILKHSWITH 685
A+DL+ L +P QR A + +H + H
Sbjct: 295 DARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRH 330
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 275 bits (704), Expect = 9e-74
Identities = 151/378 (39%), Positives = 227/378 (60%), Gaps = 15/378 (3%)
Query: 29 NGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVF 88
+GLK +E + + S D +E+ ++ + + + +FE LK+LG+G+FGKV
Sbjct: 108 DGLKKQEEEEMDFRSGSPSDNSGAEEMEVS--LAKPKHRVTMNEFEYLKLLGKGTFGKVI 165
Query: 89 LVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 147
LV++K G+ YAMK+LKK + +D V T E +L HPF+ L Y+FQT +
Sbjct: 166 LVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 148 LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH-QLGIVYRDLKPENILL 206
L ++++ GG++F LS+E +F+E+ +FY AE+ ALD+LH + +VYRDLK EN++L
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 207 DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEM 266
D+ GHIK+TDFGL KE + +FCGT EY+APEV+ + ++ DWW GV+M+EM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342
Query: 267 LTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL--GSEGVEEI 324
+ G LPF +D + +IL ++ P+ L EA+SLL L K++P RL GSE +EI
Sbjct: 343 MCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402
Query: 325 KRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK----TPKDSPGLPASAN 380
+H FFA I W +Y++++ PPFKP DT FD EFTA+ TP D +
Sbjct: 403 MQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVD 462
Query: 381 AHQL--FKGFSFVATSIA 396
+ + F FS+ A+ A
Sbjct: 463 SERRPHFPQFSYSASGTA 480
Score = 102 bits (253), Expect = 2e-21
Identities = 79/267 (29%), Positives = 128/267 (47%), Gaps = 23/267 (8%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPN 479
+E + +G G++ T +A+KI+ K +E+ +++ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-G 538
+ LK F + V + GGEL + +++ FSE A I +DYLH +
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
VV+RDLK N++ +D+ I+I DFG K+ + + T C T ++APEVL
Sbjct: 270 VVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 599 YDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKD 658
Y A D W LGV+ Y M+ G PF N ++ E++L + +F + + AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFPRT------LGPEAKS 378
Query: 659 LLSHMLHMDPHQRY-----TAEQILKH 680
LLS +L DP QR A++I++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 275 bits (704), Expect = 9e-74
Identities = 151/378 (39%), Positives = 227/378 (60%), Gaps = 15/378 (3%)
Query: 29 NGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVF 88
+GLK +E + + S D +E+ ++ + + + +FE LK+LG+G+FGKV
Sbjct: 108 DGLKKQEEEEMDFRSGSPSDNSGAEEMEVS--LAKPKHRVTMNEFEYLKLLGKGTFGKVI 165
Query: 89 LVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 147
LV++K G+ YAMK+LKK + +D V T E +L HPF+ L Y+FQT +
Sbjct: 166 LVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 148 LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH-QLGIVYRDLKPENILL 206
L ++++ GG++F LS+E +F+E+ +FY AE+ ALD+LH + +VYRDLK EN++L
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 207 DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEM 266
D+ GHIK+TDFGL KE + +FCGT EY+APEV+ + ++ DWW GV+M+EM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342
Query: 267 LTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL--GSEGVEEI 324
+ G LPF +D + +IL ++ P+ L EA+SLL L K++P RL GSE +EI
Sbjct: 343 MCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402
Query: 325 KRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK----TPKDSPGLPASAN 380
+H FFA I W +Y++++ PPFKP DT FD EFTA+ TP D +
Sbjct: 403 MQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVD 462
Query: 381 AHQL--FKGFSFVATSIA 396
+ + F FS+ A+ A
Sbjct: 463 SERRPHFPQFSYSASGTA 480
Score = 102 bits (253), Expect = 2e-21
Identities = 79/267 (29%), Positives = 128/267 (47%), Gaps = 23/267 (8%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPN 479
+E + +G G++ T +A+KI+ K +E+ +++ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-G 538
+ LK F + V + GGEL + +++ FSE A I +DYLH +
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
VV+RDLK N++ +D+ I+I DFG K+ + + T C T ++APEVL
Sbjct: 270 VVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 599 YDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKD 658
Y A D W LGV+ Y M+ G PF N ++ E++L + +F + + AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFPRT------LGPEAKS 378
Query: 659 LLSHMLHMDPHQRY-----TAEQILKH 680
LLS +L DP QR A++I++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 275 bits (704), Expect = 9e-74
Identities = 151/378 (39%), Positives = 227/378 (60%), Gaps = 15/378 (3%)
Query: 29 NGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVF 88
+GLK +E + + S D +E+ ++ + + + +FE LK+LG+G+FGKV
Sbjct: 108 DGLKKQEEEEMDFRSGSPSDNSGAEEMEVS--LAKPKHRVTMNEFEYLKLLGKGTFGKVI 165
Query: 89 LVRKKTGPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 147
LV++K G+ YAMK+LKK + +D V T E +L HPF+ L Y+FQT +
Sbjct: 166 LVKEKA---TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222
Query: 148 LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH-QLGIVYRDLKPENILL 206
L ++++ GG++F LS+E +F+E+ +FY AE+ ALD+LH + +VYRDLK EN++L
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282
Query: 207 DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEM 266
D+ GHIK+TDFGL KE + +FCGT EY+APEV+ + ++ DWW GV+M+EM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342
Query: 267 LTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRL--GSEGVEEI 324
+ G LPF +D + +IL ++ P+ L EA+SLL L K++P RL GSE +EI
Sbjct: 343 MCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEI 402
Query: 325 KRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK----TPKDSPGLPASAN 380
+H FFA I W +Y++++ PPFKP DT FD EFTA+ TP D +
Sbjct: 403 MQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVD 462
Query: 381 AHQL--FKGFSFVATSIA 396
+ + F FS+ A+ A
Sbjct: 463 SERRPHFPQFSYSASGTA 480
Score = 102 bits (253), Expect = 2e-21
Identities = 79/267 (29%), Positives = 128/267 (47%), Gaps = 23/267 (8%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPN 479
+E + +G G++ T +A+KI+ K +E+ +++ +HP
Sbjct: 150 FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF 209
Query: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-G 538
+ LK F + V + GGEL + +++ FSE A I +DYLH +
Sbjct: 210 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 269
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
VV+RDLK N++ +D+ I+I DFG K+ + + T C T ++APEVL
Sbjct: 270 VVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 599 YDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKD 658
Y A D W LGV+ Y M+ G PF N ++ E++L + +F + + AK
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRFPRT------LGPEAKS 378
Query: 659 LLSHMLHMDPHQRY-----TAEQILKH 680
LLS +L DP QR A++I++H
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQH 405
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 273 bits (698), Expect = 4e-73
Identities = 146/331 (44%), Positives = 206/331 (62%), Gaps = 11/331 (3%)
Query: 68 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKAS-LKVRDRVRTKMERDI 126
A P F+ LKV+G+G++GKV L ++K+ G YA+KVL+K S LK +++ ER +
Sbjct: 30 AQPTDFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKKKEQSHIMAERSV 86
Query: 127 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
L++ V HPF+V L Y+FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 146
Query: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 245
+ +LH L I+YRDLKPENILLD GH+ LTDFGL KE V+ E +FCGT EY+APEV+
Sbjct: 147 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 206
Query: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
+ + ++ DWW G +++EML G PF +D ++ IL L +P + A LL+
Sbjct: 207 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 266
Query: 306 MLFKRNPANRLGSEG-VEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 364
L ++ RLGS+ EIK H+FF+ I+WD LY + + PPF P P D FDPEF
Sbjct: 267 SLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEF 326
Query: 365 TAKTPKDSPG-----LPASANAHQLFKGFSF 390
T + S G + +S+ A F GFS+
Sbjct: 327 TQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
Score = 108 bits (269), Expect = 2e-23
Identities = 75/253 (29%), Positives = 119/253 (47%), Gaps = 18/253 (7%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS----KRDPSE---EIEILMRYGQHP 478
++ + IG G+Y + +AVK++ K K++ S E +L++ +HP
Sbjct: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 94
Query: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
++ L+ F +Y V D + GGEL + +++ F E A ++ + YLH
Sbjct: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 154
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
+++RDLKP NIL + + + DFG K+ T C T ++APEVL ++
Sbjct: 155 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 210
Query: 599 YDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKD 658
YD A D W LG + Y ML G PF + E +L + + GG + A D
Sbjct: 211 YDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL---HQPLQIPGGR----TVAACD 263
Query: 659 LLSHMLHMDPHQR 671
LL +LH D QR
Sbjct: 264 LLQSLLHKDQRQR 276
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 273 bits (698), Expect = 4e-73
Identities = 146/331 (44%), Positives = 206/331 (62%), Gaps = 11/331 (3%)
Query: 68 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKAS-LKVRDRVRTKMERDI 126
A P F+ LKV+G+G++GKV L ++K+ G YA+KVL+K S LK +++ ER +
Sbjct: 90 AQPTDFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKKKEQSHIMAERSV 146
Query: 127 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
L++ V HPF+V L Y+FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 206
Query: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 245
+ +LH L I+YRDLKPENILLD GH+ LTDFGL KE V+ E +FCGT EY+APEV+
Sbjct: 207 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 266
Query: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
+ + ++ DWW G +++EML G PF +D ++ IL L +P + A LL+
Sbjct: 267 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 326
Query: 306 MLFKRNPANRLGSEG-VEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 364
L ++ RLGS+ EIK H+FF+ I+WD LY + + PPF P P D FDPEF
Sbjct: 327 SLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEF 386
Query: 365 TAKTPKDSPG-----LPASANAHQLFKGFSF 390
T + S G + +S+ A F GFS+
Sbjct: 387 TQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
Score = 108 bits (269), Expect = 2e-23
Identities = 75/253 (29%), Positives = 119/253 (47%), Gaps = 18/253 (7%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS----KRDPSE---EIEILMRYGQHP 478
++ + IG G+Y + +AVK++ K K++ S E +L++ +HP
Sbjct: 95 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP 154
Query: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
++ L+ F +Y V D + GGEL + +++ F E A ++ + YLH
Sbjct: 155 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN 214
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
+++RDLKP NIL + + + DFG K+ T C T ++APEVL ++
Sbjct: 215 IIYRDLKPENILLDCQG----HVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEP 270
Query: 599 YDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKD 658
YD A D W LG + Y ML G PF + E +L + + GG + A D
Sbjct: 271 YDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL---HQPLQIPGGR----TVAACD 323
Query: 659 LLSHMLHMDPHQR 671
LL +LH D QR
Sbjct: 324 LLQSLLHKDQRQR 336
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 273 bits (697), Expect = 6e-73
Identities = 138/319 (43%), Positives = 204/319 (63%), Gaps = 11/319 (3%)
Query: 58 THHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDR 117
THH ++ F+ LK+LG+G+FGKV LVR+K +G+ YAMK+LKK + +D
Sbjct: 138 THHKRKTMN-----DFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDE 189
Query: 118 V-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVK 176
V T E +L HPF+ L Y+FQT+ +L +++++ GG++F LS+E +F+E+ +
Sbjct: 190 VAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTR 249
Query: 177 FYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGT 236
FY AE+ ALD+LH IVYRDLK EN++LD+ GHIK+TDFGL KE + +FCGT
Sbjct: 250 FYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT 309
Query: 237 VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFL 296
EY+APEV+ + ++ DWW GV+M+EM+ G LPF +D + +IL + P+ L
Sbjct: 310 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTL 369
Query: 297 SAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKP 354
S++A+SLL L ++P RLG + +EI RH FF+ ++W +Y +++ PPFKP
Sbjct: 370 SSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSE 429
Query: 355 DDTFCFDPEFTAKTPKDSP 373
DT FD EFTA+T +P
Sbjct: 430 TDTRYFDEEFTAQTITITP 448
Score = 105 bits (261), Expect = 2e-22
Identities = 77/264 (29%), Positives = 131/264 (49%), Gaps = 22/264 (8%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPNIITLKD 485
+G G++ + +A+KI+ K +E+ +++ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
F + V + + GGEL + +++ FSE I +DYLH +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 546 PSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDI 605
N++ +D+ I+I DFG K+ + + T C T ++APEVL Y A D
Sbjct: 274 LENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 606 WSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLH 665
W LGV+ Y M+ G PF N ++ E++L + + KF + +S AK LLS +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFPRT------LSSDAKSLLSGLLI 382
Query: 666 MDPHQRY-----TAEQILKHSWIT 684
DP++R A++I++HS+ +
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFS 406
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 273 bits (697), Expect = 6e-73
Identities = 138/319 (43%), Positives = 204/319 (63%), Gaps = 11/319 (3%)
Query: 58 THHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDR 117
THH ++ F+ LK+LG+G+FGKV LVR+K +G+ YAMK+LKK + +D
Sbjct: 138 THHKRKTMN-----DFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDE 189
Query: 118 V-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVK 176
V T E +L HPF+ L Y+FQT+ +L +++++ GG++F LS+E +F+E+ +
Sbjct: 190 VAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTR 249
Query: 177 FYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGT 236
FY AE+ ALD+LH IVYRDLK EN++LD+ GHIK+TDFGL KE + +FCGT
Sbjct: 250 FYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGT 309
Query: 237 VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFL 296
EY+APEV+ + ++ DWW GV+M+EM+ G LPF +D + +IL + P+ L
Sbjct: 310 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTL 369
Query: 297 SAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKP 354
S++A+SLL L ++P RLG + +EI RH FF+ ++W +Y +++ PPFKP
Sbjct: 370 SSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSE 429
Query: 355 DDTFCFDPEFTAKTPKDSP 373
DT FD EFTA+T +P
Sbjct: 430 TDTRYFDEEFTAQTITITP 448
Score = 105 bits (261), Expect = 2e-22
Identities = 77/264 (29%), Positives = 131/264 (49%), Gaps = 22/264 (8%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPNIITLKD 485
+G G++ + +A+KI+ K +E+ +++ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
F + V + + GGEL + +++ FSE I +DYLH +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 546 PSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDI 605
N++ +D+ I+I DFG K+ + + T C T ++APEVL Y A D
Sbjct: 274 LENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 606 WSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLH 665
W LGV+ Y M+ G PF N ++ E++L + + KF + +S AK LLS +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFPRT------LSSDAKSLLSGLLI 382
Query: 666 MDPHQRY-----TAEQILKHSWIT 684
DP++R A++I++HS+ +
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFS 406
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 272 bits (695), Expect = 9e-73
Identities = 146/334 (43%), Positives = 207/334 (61%), Gaps = 14/334 (4%)
Query: 68 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDI 126
A P+ F LKV+G+GSFGKV L R K YA+KVL KKA LK ++ ER++
Sbjct: 93 AKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 127 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
L++ V HPF+V LH++FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
Query: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 245
L +LH L IVYRDLKPENILLD GHI LTDFGL KE+++ +FCGT EY+APEV+
Sbjct: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
Query: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
+++ + ++ DWW G +++EML G PF ++ E + IL L + ++ A+ LL
Sbjct: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
Query: 306 MLFKRNPANRLGS-EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 364
L +++ RLG+ + EIK H+FF+ I+WD L +++ PPF P P+D FDPEF
Sbjct: 330 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 389
Query: 365 TAKTPKDSPGLPASA--------NAHQLFKGFSF 390
T + +S G + A + F GFS+
Sbjct: 390 TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 423
Score = 115 bits (287), Expect = 2e-25
Identities = 80/251 (31%), Positives = 117/251 (46%), Gaps = 18/251 (7%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHPNIITLK 484
IG GS+ H + +AVK++ K ++ E +L++ +HP ++ L
Sbjct: 104 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 163
Query: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
F +Y V D + GGEL + +++CF E A I+ + YLH +V+RDL
Sbjct: 164 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 223
Query: 545 KPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACD 604
KP NIL S I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 224 KPENILL----DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 279
Query: 605 IWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHML 664
W LG + Y ML G PF + E+ I N L NI++ A+ LL +L
Sbjct: 280 WWCLGAVLYEMLYGLPPFY---SRNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 332
Query: 665 HMDPHQRYTAE 675
D +R A+
Sbjct: 333 QKDRTKRLGAK 343
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 272 bits (695), Expect = 9e-73
Identities = 146/334 (43%), Positives = 207/334 (61%), Gaps = 14/334 (4%)
Query: 68 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDI 126
A P+ F LKV+G+GSFGKV L R K YA+KVL KKA LK ++ ER++
Sbjct: 107 AKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 127 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
L++ V HPF+V LH++FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 164 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 223
Query: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 245
L +LH L IVYRDLKPENILLD GHI LTDFGL KE+++ +FCGT EY+APEV+
Sbjct: 224 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 283
Query: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
+++ + ++ DWW G +++EML G PF ++ E + IL L + ++ A+ LL
Sbjct: 284 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 343
Query: 306 MLFKRNPANRLGS-EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 364
L +++ RLG+ + EIK H+FF+ I+WD L +++ PPF P P+D FDPEF
Sbjct: 344 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 403
Query: 365 TAKTPKDSPGLPASA--------NAHQLFKGFSF 390
T + +S G + A + F GFS+
Sbjct: 404 TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 437
Score = 115 bits (287), Expect = 2e-25
Identities = 80/251 (31%), Positives = 117/251 (46%), Gaps = 18/251 (7%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHPNIITLK 484
IG GS+ H + +AVK++ K ++ E +L++ +HP ++ L
Sbjct: 118 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 177
Query: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
F +Y V D + GGEL + +++CF E A I+ + YLH +V+RDL
Sbjct: 178 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 237
Query: 545 KPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACD 604
KP NIL S I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 238 KPENILL----DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 293
Query: 605 IWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHML 664
W LG + Y ML G PF + E+ I N L NI++ A+ LL +L
Sbjct: 294 WWCLGAVLYEMLYGLPPFY---SRNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 346
Query: 665 HMDPHQRYTAE 675
D +R A+
Sbjct: 347 QKDRTKRLGAK 357
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 272 bits (695), Expect = 9e-73
Identities = 146/334 (43%), Positives = 207/334 (61%), Gaps = 14/334 (4%)
Query: 68 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDI 126
A P+ F LKV+G+GSFGKV L R K YA+KVL KKA LK ++ ER++
Sbjct: 121 AKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 127 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
L++ V HPF+V LH++FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
Query: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 245
L +LH L IVYRDLKPENILLD GHI LTDFGL KE+++ +FCGT EY+APEV+
Sbjct: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
Query: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
+++ + ++ DWW G +++EML G PF ++ E + IL L + ++ A+ LL
Sbjct: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
Query: 306 MLFKRNPANRLGS-EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 364
L +++ RLG+ + EIK H+FF+ I+WD L +++ PPF P P+D FDPEF
Sbjct: 358 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 417
Query: 365 TAKTPKDSPGLPASA--------NAHQLFKGFSF 390
T + +S G + A + F GFS+
Sbjct: 418 TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 451
Score = 115 bits (287), Expect = 2e-25
Identities = 80/251 (31%), Positives = 117/251 (46%), Gaps = 18/251 (7%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHPNIITLK 484
IG GS+ H + +AVK++ K ++ E +L++ +HP ++ L
Sbjct: 132 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 191
Query: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
F +Y V D + GGEL + +++CF E A I+ + YLH +V+RDL
Sbjct: 192 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 251
Query: 545 KPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACD 604
KP NIL S I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 252 KPENILL----DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 307
Query: 605 IWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHML 664
W LG + Y ML G PF + E+ I N L NI++ A+ LL +L
Sbjct: 308 WWCLGAVLYEMLYGLPPFY---SRNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 360
Query: 665 HMDPHQRYTAE 675
D +R A+
Sbjct: 361 QKDRTKRLGAK 371
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 272 bits (695), Expect = 9e-73
Identities = 146/334 (43%), Positives = 207/334 (61%), Gaps = 14/334 (4%)
Query: 68 ADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDI 126
A P+ F LKV+G+GSFGKV L R K YA+KVL KKA LK ++ ER++
Sbjct: 188 AKPSDFHFLKVIGKGSFGKVLLARHKAEE---VFYAVKVLQKKAILKKKEEKHIMSERNV 244
Query: 127 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALA 185
L++ V HPF+V LH++FQT KLY +LD++ GG++F L +E F E +FY AE+A A
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
Query: 186 LDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVV 245
L +LH L IVYRDLKPENILLD GHI LTDFGL KE+++ +FCGT EY+APEV+
Sbjct: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
Query: 246 NRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLR 305
+++ + ++ DWW G +++EML G PF ++ E + IL L + ++ A+ LL
Sbjct: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
Query: 306 MLFKRNPANRLGS-EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEF 364
L +++ RLG+ + EIK H+FF+ I+WD L +++ PPF P P+D FDPEF
Sbjct: 425 GLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEF 484
Query: 365 TAKTPKDSPGLPASA--------NAHQLFKGFSF 390
T + +S G + A + F GFS+
Sbjct: 485 TEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSY 518
Score = 115 bits (287), Expect = 2e-25
Identities = 80/251 (31%), Positives = 117/251 (46%), Gaps = 18/251 (7%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHPNIITLK 484
IG GS+ H + +AVK++ K ++ E +L++ +HP ++ L
Sbjct: 199 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 258
Query: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
F +Y V D + GGEL + +++CF E A I+ + YLH +V+RDL
Sbjct: 259 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 318
Query: 545 KPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACD 604
KP NIL S I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 319 KPENILL----DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 374
Query: 605 IWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHML 664
W LG + Y ML G PF + E+ I N L NI++ A+ LL +L
Sbjct: 375 WWCLGAVLYEMLYGLPPFY---SRNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 427
Query: 665 HMDPHQRYTAE 675
D +R A+
Sbjct: 428 QKDRTKRLGAK 438
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 270 bits (691), Expect = 3e-72
Identities = 142/344 (41%), Positives = 209/344 (60%), Gaps = 13/344 (3%)
Query: 35 DEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKT 94
++PM+ + S D +E+ + V + K F+ LK+LG+G+FGKV LVR+K
Sbjct: 117 EDPMDY-KCGSPSDSSTTEEMEVA--VSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA 173
Query: 95 GPDAGQLYAMKVLKKASLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILD 153
G+ YAMK+L+K + +D V T E +L HPF+ L YAFQT +L +++
Sbjct: 174 ---TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVME 230
Query: 154 FLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIK 213
+ GG++F LS+E +FTEE +FY AE+ AL++LH +VYRD+K EN++LD+ GHIK
Sbjct: 231 YANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIK 290
Query: 214 LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPF 273
+TDFGL KE + +FCGT EY+APEV+ + ++ DWW GV+M+EM+ G LPF
Sbjct: 291 ITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 350
Query: 274 QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFA 331
+D +IL ++ P+ LS EA+SLL L K++P RLG +E+ H FF
Sbjct: 351 YNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFL 410
Query: 332 NIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK----TPKD 371
+I+W + ++++ PPFKP DT FD EFTA+ TP D
Sbjct: 411 SINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPD 454
Score = 102 bits (255), Expect = 1e-21
Identities = 74/260 (28%), Positives = 126/260 (48%), Gaps = 22/260 (8%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI------EILMRYGQHPNIITLKD 485
+G G++ T +A+KI+ K +E+ +++ +HP + LK
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
F + V + GGEL + +++ F+E A I ++YLH + VV+RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 546 PSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDI 605
N++ +D+ I+I DFG K+ + + T C T ++APEVL Y A D
Sbjct: 278 LENLM-LDKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
Query: 606 WSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLH 665
W LGV+ Y M+ G PF N ++ E++L + +F + +S AK LL+ +L
Sbjct: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFPRT------LSPEAKSLLAGLLK 386
Query: 666 MDPHQRY-----TAEQILKH 680
DP QR A+++++H
Sbjct: 387 KDPKQRLGGGPSDAKEVMEH 406
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 269 bits (687), Expect = 8e-72
Identities = 154/383 (40%), Positives = 218/383 (56%), Gaps = 18/383 (4%)
Query: 27 EVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV----KEGYEKADPAQFELLKVLGQG 82
+V +D P + + DE +++ T G A P F+ LKV+G+G
Sbjct: 112 DVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKG 171
Query: 83 SFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDILVE-VNHPFIVKLHY 140
SFGKV L ++K G+ YA+KVL KK L +++ ER++L++ V HPF+V LHY
Sbjct: 172 SFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
Query: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200
+FQT KLY +LDF+ GG++F L +E F E +FY AE+A AL +LH + IVYRDLK
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
Query: 201 PENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYG 260
PENILLD +GH+ LTDFGL KE + +FCGT EY+APEV+ ++ + + DWW G
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
Query: 261 VLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS-E 319
+++EML G PF +D E + IL L + +S A S+L L +++ NRLG+ E
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE 408
Query: 320 GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKT-------PKDS 372
EI+ H FF ++ W L ++++ PPF P PDD FD FT +T D
Sbjct: 409 DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDY 468
Query: 373 PGLPASA-NAHQLFKGFSFVATS 394
+ AS A F GFS+ S
Sbjct: 469 SIVNASVLEADDAFVGFSYAPPS 491
Score = 99.8 bits (247), Expect = 8e-21
Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 11/204 (5%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHP 478
++ + IG GS+ +AVK++ K ++ E +L++ +HP
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
++ L F +Y V D + GGEL + +++ F E A I+ + YLH
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
+V+RDLKP NIL S + + DFG K+ + T C T ++APEV+ +Q
Sbjct: 282 IVYRDLKPENILL----DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337
Query: 599 YDAACDIWSLGVLFYTMLAGYTPF 622
YD D W LG + Y ML G PF
Sbjct: 338 YDNTVDWWCLGAVLYEMLYGLPPF 361
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 269 bits (687), Expect = 8e-72
Identities = 154/383 (40%), Positives = 218/383 (56%), Gaps = 18/383 (4%)
Query: 27 EVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV----KEGYEKADPAQFELLKVLGQG 82
+V +D P + + DE +++ T G A P F+ LKV+G+G
Sbjct: 112 DVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKG 171
Query: 83 SFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDILVE-VNHPFIVKLHY 140
SFGKV L ++K G+ YA+KVL KK L +++ ER++L++ V HPF+V LHY
Sbjct: 172 SFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
Query: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200
+FQT KLY +LDF+ GG++F L +E F E +FY AE+A AL +LH + IVYRDLK
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
Query: 201 PENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYG 260
PENILLD +GH+ LTDFGL KE + +FCGT EY+APEV+ ++ + + DWW G
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
Query: 261 VLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS-E 319
+++EML G PF +D E + IL L + +S A S+L L +++ NRLG+ E
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE 408
Query: 320 GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKT-------PKDS 372
EI+ H FF ++ W L ++++ PPF P PDD FD FT +T D
Sbjct: 409 DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDY 468
Query: 373 PGLPASA-NAHQLFKGFSFVATS 394
+ AS A F GFS+ S
Sbjct: 469 SIVNASVLEADDAFVGFSYAPPS 491
Score = 99.8 bits (247), Expect = 8e-21
Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 11/204 (5%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHP 478
++ + IG GS+ +AVK++ K ++ E +L++ +HP
Sbjct: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
Query: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
++ L F +Y V D + GGEL + +++ F E A I+ + YLH
Sbjct: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
+V+RDLKP NIL S + + DFG K+ + T C T ++APEV+ +Q
Sbjct: 282 IVYRDLKPENILL----DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337
Query: 599 YDAACDIWSLGVLFYTMLAGYTPF 622
YD D W LG + Y ML G PF
Sbjct: 338 YDNTVDWWCLGAVLYEMLYGLPPF 361
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 249 bits (635), Expect = 9e-66
Identities = 137/326 (42%), Positives = 199/326 (61%), Gaps = 12/326 (3%)
Query: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVR-TKMERDILVEVN 131
F L VLG+GSFGKV L +K +LYA+K+LKK + D V T +E+ +L ++
Sbjct: 339 FNFLMVLGKGSFGKVMLADRK---GTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395
Query: 132 HP-FIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
P F+ +LH FQT +LY +++++ GGD+ + + F E FY AE+++ L LH
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455
Query: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250
+ GI+YRDLK +N++LD GHIK+ DFG+ KE + +FCGT +Y+APE++ + +
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 515
Query: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 310
+S DWW+YGVL++EML G PF G+D +E I++ + P+ LS EA S+ + L +
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTK 575
Query: 311 NPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKP-ASGKPDDTFCFDPEFTAK 367
+PA RL G EG +++ H FF IDW+KL RE+QPPFKP GK + FD FT
Sbjct: 576 HPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAEN--FDKFFTRG 633
Query: 368 TP-KDSPGLPASANAHQL-FKGFSFV 391
P P AN Q F+GFS+V
Sbjct: 634 QPVLTPPDQLVIANIDQSDFEGFSYV 659
Score = 91.7 bits (226), Expect = 2e-18
Identities = 60/204 (29%), Positives = 96/204 (47%), Gaps = 11/204 (5%)
Query: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHPNIITLK 484
+G GS+ T +A+KI+ K +++E +L + P + L
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
F +Y V + + GG+L+ I + F E +A IS + +LH +G+++RDL
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 464
Query: 545 KPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACD 604
K N++ E I+I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 465 KLDNVMLDSEG----HIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVD 520
Query: 605 IWSLGVLFYTMLAGYTPFANGPND 628
W+ GVL Y MLAG PF D
Sbjct: 521 WWAYGVLLYEMLAGQPPFDGEDED 544
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 248 bits (633), Expect = 1e-65
Identities = 128/307 (41%), Positives = 191/307 (62%), Gaps = 11/307 (3%)
Query: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM--ERDILVEV 130
F L VLG+GSFGKV L +K G D +LYA+K+LKK + D V M +R + +
Sbjct: 342 FNFLMVLGKGSFGKVMLSERK-GTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
PF+ +LH FQT +LY +++++ GGD+ + + F E FY AE+A+ L L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250
GI+YRDLK +N++LD GHIK+ DFG+ KE++ +FCGT +Y+APE++ + +
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 310
+S DWW++GVL++EML G PF+G+D +E I++ + P+ +S EA ++ + L +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 311 NPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK- 367
+P RL G EG +IK H FF IDW+KL ++E+QPP+KP + DT FD EFT +
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQP 638
Query: 368 ---TPKD 371
TP D
Sbjct: 639 VELTPTD 645
Score = 91.7 bits (226), Expect = 2e-18
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 12/247 (4%)
Query: 390 FVATSIAEEYKITPITSANVLPIVQINGNAAQFGEV-YELKEDIGVGSYSVCKRCIHATT 448
F I++ K+ + N + NGN + + +G GS+ T
Sbjct: 305 FERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT 364
Query: 449 NMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHPNIITLKDVFDDGRYVYLVTDLMK 501
+ +AVKI+ K +++E +L G+ P + L F +Y V + +
Sbjct: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424
Query: 502 GGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSI 561
GG+L+ I + F E A I+ + +L +G+++RDLK N++ E I
Sbjct: 425 GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG----HI 480
Query: 562 RICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTP 621
+I DFG K+ + T C T +++APE++ Q Y + D W+ GVL Y MLAG P
Sbjct: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540
Query: 622 FANGPND 628
F D
Sbjct: 541 FEGEDED 547
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 245 bits (626), Expect = 9e-65
Identities = 132/332 (39%), Positives = 192/332 (57%), Gaps = 14/332 (4%)
Query: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM--ERDILVEV 130
FE ++VLG+GSFGKV L R K + G LYA+KVLKK + D V M +R + +
Sbjct: 355 FEFIRVLGKGSFGKVMLARVK---ETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 411
Query: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
NHPF+ +L FQT +L+ +++F+ GGD+ + K F E +FY AE+ AL LH
Sbjct: 412 NHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLH 471
Query: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250
GI+YRDLK +N+LLD GH KL DFG+ KE + +FCGT +Y+APE++ +
Sbjct: 472 DKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY 531
Query: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 310
+ DWW+ GVL++EML G PF+ ++ ++ IL ++ P +L +A +L+ +
Sbjct: 532 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTK 591
Query: 311 NPANRLGS---EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAK 367
NP RLGS G I RH FF IDW +L R+++PPF+P +D FDP+F +
Sbjct: 592 NPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKE 651
Query: 368 ----TPKDSPGLPASANAHQLFKGFSFVATSI 395
TP D LP F+ FS+V+ +
Sbjct: 652 EPVLTPIDEGHLPMINQDE--FRNFSYVSPEL 681
Score = 94.4 bits (233), Expect = 4e-19
Identities = 65/217 (29%), Positives = 101/217 (46%), Gaps = 12/217 (5%)
Query: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHP 478
+E +G GS+ T +AVK++ K +++E IL HP
Sbjct: 355 FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHP 414
Query: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
+ L F ++ V + + GG+L+ I K + F E A I + +LH +G
Sbjct: 415 FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKG 474
Query: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
+++RDLK N+L E ++ DFG K+ T C T +++APE+L +
Sbjct: 475 IIYRDLKLDNVLLDHEG----HCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 530
Query: 599 YDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEEIL 634
Y A D W++GVL Y ML G+ PF A +D E IL
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL 567
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 244 bits (622), Expect = 3e-64
Identities = 134/326 (41%), Positives = 198/326 (60%), Gaps = 12/326 (3%)
Query: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKM--ERDILVEV 130
F L VLG+GSFGKV L +K G D +LYA+K+LKK + D V M +R + +
Sbjct: 342 FNFLMVLGKGSFGKVMLSERK-GTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 131 NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLH 190
PF+ +LH FQT +LY +++++ GGD+ + + F E FY AE+A+ L L
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 191 QLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGH 250
GI+YRDLK +N++LD GHIK+ DFG+ KE++ +FCGT +Y+APE++ + +
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 251 SQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKR 310
+S DWW++GVL++EML G PF+G+D +E I++ + P+ +S EA ++ + L +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
Query: 311 NPANRL--GSEGVEEIKRHLFFANIDWDKLYKREVQPPFKP-ASGKPDDTFCFDPEFTAK 367
+P RL G EG +IK H FF IDW+KL ++E+QPP+KP A G+ + FD FT
Sbjct: 579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAEN--FDRFFTRH 636
Query: 368 TP-KDSPGLPASANAHQL-FKGFSFV 391
P P N Q F+GFSFV
Sbjct: 637 PPVLTPPDQEVIRNIDQSEFEGFSFV 662
Score = 91.7 bits (226), Expect = 2e-18
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 12/247 (4%)
Query: 390 FVATSIAEEYKITPITSANVLPIVQINGNAAQFGEV-YELKEDIGVGSYSVCKRCIHATT 448
F I++ K+ + N + NGN + + +G GS+ T
Sbjct: 305 FERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGT 364
Query: 449 NMEFAVKIIDKSKRDPSEEIE-------ILMRYGQHPNIITLKDVFDDGRYVYLVTDLMK 501
+ +AVKI+ K +++E +L G+ P + L F +Y V + +
Sbjct: 365 DELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVN 424
Query: 502 GGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSI 561
GG+L+ I + F E A I+ + +L +G+++RDLK N++ E I
Sbjct: 425 GGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG----HI 480
Query: 562 RICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTP 621
+I DFG K+ + T C T +++APE++ Q Y + D W+ GVL Y MLAG P
Sbjct: 481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP 540
Query: 622 FANGPND 628
F D
Sbjct: 541 FEGEDED 547
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,341,384
Number of Sequences: 37866
Number of extensions: 1297681
Number of successful extensions: 7227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 73
Number of HSP's that attempted gapping in prelim test: 2547
Number of HSP's gapped (non-prelim): 1854
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.