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Search of human proteins with 75750472
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
(1068 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa... 2081 0.0
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 1904 0.0
gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo sa... 1513 0.0
gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo sa... 1335 0.0
gi|224451082 cytospin A [Homo sapiens] 688 0.0
gi|224451080 cytospin A [Homo sapiens] 688 0.0
gi|38044112 restin isoform b [Homo sapiens] 102 3e-21
gi|4506751 restin isoform a [Homo sapiens] 102 3e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 100 6e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 99 2e-20
gi|19913396 smoothelin isoform b [Homo sapiens] 99 2e-20
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 97 8e-20
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 97 1e-19
gi|157738619 smoothelin-like 1 [Homo sapiens] 97 1e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 96 1e-19
gi|67782321 spectrin beta isoform a [Homo sapiens] 96 2e-19
gi|67782319 spectrin beta isoform b [Homo sapiens] 96 2e-19
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 95 4e-19
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 95 4e-19
gi|19913394 smoothelin isoform c [Homo sapiens] 94 5e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 94 7e-19
gi|71061468 centromere protein E [Homo sapiens] 94 7e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 94 9e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 94 9e-19
gi|19913398 smoothelin isoform a [Homo sapiens] 92 2e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 92 3e-18
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 92 3e-18
gi|169234649 smoothelin-like 2 isoform 2 [Homo sapiens] 92 3e-18
gi|169234647 smoothelin-like 2 isoform 1 [Homo sapiens] 92 3e-18
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 91 4e-18
>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
Length = 1068
Score = 2081 bits (5392), Expect = 0.0
Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)
Query: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN
Sbjct: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
Query: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS
Sbjct: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
Query: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK
Sbjct: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
Query: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL
Sbjct: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
Query: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY
Sbjct: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
Query: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS
Sbjct: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT
Sbjct: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
Query: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE
Sbjct: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
Query: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC
Sbjct: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
Query: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE
Sbjct: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD
Sbjct: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE
Sbjct: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
Query: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR
Sbjct: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
Query: 781 AAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNIS 840
AAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNIS
Sbjct: 781 AAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNIS 840
Query: 841 VHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRT 900
VHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRT
Sbjct: 841 VHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRT 900
Query: 901 ETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREY 960
ETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREY
Sbjct: 901 ETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREY 960
Query: 961 GGSKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKK 1020
GGSKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKK
Sbjct: 961 GGSKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKK 1020
Query: 1021 RNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET 1068
RNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET
Sbjct: 1021 RNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET 1068
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 1904 bits (4931), Expect = 0.0
Identities = 974/974 (100%), Positives = 974/974 (100%)
Query: 95 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 154
GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP
Sbjct: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 73
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG
Sbjct: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS
Sbjct: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
Sbjct: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT
Sbjct: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
Query: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE
Sbjct: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE
Sbjct: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT
Sbjct: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
Query: 575 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 634
AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD
Sbjct: 494 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 553
Query: 635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 694
HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI
Sbjct: 554 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 613
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL
Sbjct: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
Query: 755 EEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPP 814
EEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPP
Sbjct: 674 EEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPP 733
Query: 815 ESATTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSV 874
ESATTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSV
Sbjct: 734 ESATTVKSLIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSV 793
Query: 875 RPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSA 934
RPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSA
Sbjct: 794 RPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSA 853
Query: 935 STRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKWCQKKTQGYANIDITNFSSSWSDG 994
STRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKWCQKKTQGYANIDITNFSSSWSDG
Sbjct: 854 STRAWKPQSKLSVERKDPLAALAREYGGSKRNALLKWCQKKTQGYANIDITNFSSSWSDG 913
Query: 995 LAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQS 1054
LAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQS
Sbjct: 914 LAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQS 973
Query: 1055 VMQYVAQIYKYFET 1068
VMQYVAQIYKYFET
Sbjct: 974 VMQYVAQIYKYFET 987
>gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo
sapiens]
Length = 790
Score = 1513 bits (3916), Expect = 0.0
Identities = 784/784 (100%), Positives = 784/784 (100%)
Query: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN
Sbjct: 1 MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN 60
Query: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS
Sbjct: 61 KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS 120
Query: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK
Sbjct: 121 VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK 180
Query: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL
Sbjct: 181 DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL 240
Query: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY
Sbjct: 241 SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY 300
Query: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS
Sbjct: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT
Sbjct: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT 420
Query: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE
Sbjct: 421 ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE 480
Query: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC
Sbjct: 481 REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
Query: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE
Sbjct: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD
Sbjct: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD 660
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE
Sbjct: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE 720
Query: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR
Sbjct: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR 780
Query: 781 AAPP 784
AAPP
Sbjct: 781 AAPP 784
>gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
Length = 709
Score = 1335 bits (3455), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 95 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 154
GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP
Sbjct: 14 GAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKP 73
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG
Sbjct: 74 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 133
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS
Sbjct: 134 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 193
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI
Sbjct: 194 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 253
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT
Sbjct: 254 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 313
Query: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE
Sbjct: 314 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 373
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE
Sbjct: 374 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 433
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT
Sbjct: 434 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 493
Query: 575 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 634
AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD
Sbjct: 494 AESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICD 553
Query: 635 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 694
HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI
Sbjct: 554 HQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVI 613
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 754
KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL
Sbjct: 614 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLL 673
Query: 755 EEEEKNARLQKELGDVQGHGRVVTSRAAPP 784
EEEEKNARLQKELGDVQGHGRVVTSRAAPP
Sbjct: 674 EEEEKNARLQKELGDVQGHGRVVTSRAAPP 703
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 688 bits (1776), Expect = 0.0
Identities = 450/1118 (40%), Positives = 645/1118 (57%), Gaps = 109/1118 (9%)
Query: 27 AASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN--KPGSTAASGVVRLKKTATAGAISE 84
+AS+G K K T+ + K SS+D L G T +GV K T + A S
Sbjct: 33 SASTGGKLVKPGTAASLS------KTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSA 86
Query: 85 ------LTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSS 138
E++ + TG ++TKR+ +E S T R R R + +K S+ +
Sbjct: 87 SAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTR-LNQSKKLPSAGQGA 145
Query: 139 NTPTPTKHLRTPS--------TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSE 190
N K R+ + +K K +N+ ++AALE++V++LL AK KD EI LR+E
Sbjct: 146 NDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNE 205
Query: 191 LKKYKEKRTLNAEGTDALGPNVDGTSVS--PGDTEPMIRALEEKNKNFQKELSDLEEENR 248
L+ + + +N + ++ + T ++ P D E + L+E+N ++EL+ L+ ENR
Sbjct: 206 LRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENR 265
Query: 249 VLKEKLIYLEHS-----PNSEGAASHTGDSSCPTSITQESSFGSPTGNQ----------- 292
+LK++L L S NSE + S T Q G+ T +
Sbjct: 266 MLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDL 325
Query: 293 MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKS 352
+S D + + H N++ S S+V + S D + P SS S S
Sbjct: 326 LSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD---------DALDAPSSSESEGIPS 376
Query: 353 SKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAEN 412
+ S GSS N+ SE+S+A LTE+I +MEEN HST+EELQATLQEL+D QQ+ QEL +EN
Sbjct: 377 IERSRKGSSGNA-SEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSEN 435
Query: 413 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIELEQ 468
E+L +EK IL S Q ++ E S++ E +LL E V +E+ + G+ +ELEQ
Sbjct: 436 ERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDED--VKSGRYMELEQ 493
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 528
+ + E RFERE+LL +QQ L+ +L+ E++N+ A EMI LKE + + +E E+
Sbjct: 494 RYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQK 553
Query: 529 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 588
+A TLEE + T+ ++E LK+ L+ EKQK E ++ + + ++Q++L+ R
Sbjct: 554 GKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVR 613
Query: 589 AEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 648
+K+ E + L+++L + + +AKVE +Y +E Q E L+ T KL+
Sbjct: 614 LDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLR 673
Query: 649 EKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK 708
E + E DMKETIFELED+VEQHRAVKLH+N +IS+LE++V KL++QK D+ER++K
Sbjct: 674 SDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIK 733
Query: 709 TLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELG 768
TL ++++EE+ EWR+FQADLQTAVV+ANDIK EAQ+E+ +KR+L E +EKN +L KEL
Sbjct: 734 TLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELE 793
Query: 769 DVQG------HGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKS 822
+++ GRV A E D A G+ +SR S T E TVK+
Sbjct: 794 EIKSRKQEEERGRVYNYMNA----------VERDLAALRQGMGLSRRSSTSSEPTPTVKT 843
Query: 823 LIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHS---TYSSVRPASR 879
LIKSFD N + PR+PLS P++T PAAAVSPMQRHS S+ +P +
Sbjct: 844 LIKSFD---SASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTA 900
Query: 880 GVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLE-----SLSRPPS----------- 923
+R + ++P+ + L RT + L + P++E S+SR S
Sbjct: 901 LSDKRPNYGEIPVQEHLL-RTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQE 959
Query: 924 -------LGFGDT----RLLSASTRAWKP--QSKLSVERKDPLAALAREYGGSKRNALLK 970
+ G T L S+ T + P +S++ ERKDPL+ALAREYGGSKRNALLK
Sbjct: 960 GASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLK 1019
Query: 971 WCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAA 1030
WCQKKT+GY NIDITNFSSSW+DGLAFCALLHTYLPAHIPYQELNSQ+K+RN +LAF+AA
Sbjct: 1020 WCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAA 1079
Query: 1031 ESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET 1068
ESVGIK +L+++EM+ T+RPDWQ+VM YV IYKYFET
Sbjct: 1080 ESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFET 1117
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 688 bits (1776), Expect = 0.0
Identities = 450/1118 (40%), Positives = 645/1118 (57%), Gaps = 109/1118 (9%)
Query: 27 AASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN--KPGSTAASGVVRLKKTATAGAISE 84
+AS+G K K T+ + K SS+D L G T +GV K T + A S
Sbjct: 33 SASTGGKLVKPGTAASLS------KTKSSDDLLAGMAGGVTVTNGVKGKKSTCPSAAPSA 86
Query: 85 ------LTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSS 138
E++ + TG ++TKR+ +E S T R R R + +K S+ +
Sbjct: 87 SAPAMTTVENKSKISTGTASSTKRSTSTGNKESSSTRERLRERTR-LNQSKKLPSAGQGA 145
Query: 139 NTPTPTKHLRTPS--------TKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSE 190
N K R+ + +K K +N+ ++AALE++V++LL AK KD EI LR+E
Sbjct: 146 NDMALAKRSRSRTATECDVRMSKSKSDNQISDRAALEAKVKDLLTLAKTKDVEILHLRNE 205
Query: 191 LKKYKEKRTLNAEGTDALGPNVDGTSVS--PGDTEPMIRALEEKNKNFQKELSDLEEENR 248
L+ + + +N + ++ + T ++ P D E + L+E+N ++EL+ L+ ENR
Sbjct: 206 LRDMRAQLGINEDHSEGDEKSEKETIMAHQPTDVESTLLQLQEQNTAIREELNQLKNENR 265
Query: 249 VLKEKLIYLEHS-----PNSEGAASHTGDSSCPTSITQESSFGSPTGNQ----------- 292
+LK++L L S NSE + S T Q G+ T +
Sbjct: 266 MLKDRLNALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDL 325
Query: 293 MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKS 352
+S D + + H N++ S S+V + S D + P SS S S
Sbjct: 326 LSQDENTLMDHQHSNSMDNLDSECSEVYQPLTSSD---------DALDAPSSSESEGIPS 376
Query: 353 SKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAEN 412
+ S GSS N+ SE+S+A LTE+I +MEEN HST+EELQATLQEL+D QQ+ QEL +EN
Sbjct: 377 IERSRKGSSGNA-SEVSVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSEN 435
Query: 413 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER----VKNEEPTTQEGKIIELEQ 468
E+L +EK IL S Q ++ E S++ E +LL E V +E+ + G+ +ELEQ
Sbjct: 436 ERLGEEKVILMESLCQQSDKLEHFSRQIEYFRSLLDEHHISYVIDED--VKSGRYMELEQ 493
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERH 528
+ + E RFERE+LL +QQ L+ +L+ E++N+ A EMI LKE + + +E E+
Sbjct: 494 RYMDLAENARFEREQLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQK 553
Query: 529 NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 588
+A TLEE + T+ ++E LK+ L+ EKQK E ++ + + ++Q++L+ R
Sbjct: 554 GKAALAATLEEYKATVASDQIEMNRLKAQLENEKQKVAELYSIHNSGDKSDIQDLLESVR 613
Query: 589 AEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ 648
+K+ E + L+++L + + +AKVE +Y +E Q E L+ T KL+
Sbjct: 614 LDKEKAETLASSLQEDLAHTRNDANRLQDAIAKVEDEYRAFQEEAKKQIEDLNMTLEKLR 673
Query: 649 EKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLK 708
E + E DMKETIFELED+VEQHRAVKLH+N +IS+LE++V KL++QK D+ER++K
Sbjct: 674 SDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDMEREIK 733
Query: 709 TLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELG 768
TL ++++EE+ EWR+FQADLQTAVV+ANDIK EAQ+E+ +KR+L E +EKN +L KEL
Sbjct: 734 TLHRRLREESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELE 793
Query: 769 DVQG------HGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKS 822
+++ GRV A E D A G+ +SR S T E TVK+
Sbjct: 794 EIKSRKQEEERGRVYNYMNA----------VERDLAALRQGMGLSRRSSTSSEPTPTVKT 843
Query: 823 LIKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHS---TYSSVRPASR 879
LIKSFD N + PR+PLS P++T PAAAVSPMQRHS S+ +P +
Sbjct: 844 LIKSFD---SASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPISTSKPLTA 900
Query: 880 GVTQRLDLPDLPLSDILKGRTETLKPDPHLRKSPSLE-----SLSRPPS----------- 923
+R + ++P+ + L RT + L + P++E S+SR S
Sbjct: 901 LSDKRPNYGEIPVQEHLL-RTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQE 959
Query: 924 -------LGFGDT----RLLSASTRAWKP--QSKLSVERKDPLAALAREYGGSKRNALLK 970
+ G T L S+ T + P +S++ ERKDPL+ALAREYGGSKRNALLK
Sbjct: 960 GASPASLMAMGTTSPQLSLSSSPTASVTPTTRSRIREERKDPLSALAREYGGSKRNALLK 1019
Query: 971 WCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAA 1030
WCQKKT+GY NIDITNFSSSW+DGLAFCALLHTYLPAHIPYQELNSQ+K+RN +LAF+AA
Sbjct: 1020 WCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFMLAFQAA 1079
Query: 1031 ESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET 1068
ESVGIK +L+++EM+ T+RPDWQ+VM YV IYKYFET
Sbjct: 1080 ESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFET 1117
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 102 bits (253), Expect = 3e-21
Identities = 135/639 (21%), Positives = 271/639 (42%), Gaps = 85/639 (13%)
Query: 156 QENEGGEKAA----LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 211
Q + E+AA +E+ +L+ K K++ + +RS+L K +++ + E D L
Sbjct: 632 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLN-K 688
Query: 212 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + + E L+ K K + + + + +EKL+ L+
Sbjct: 689 LQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD------------- 731
Query: 272 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 331
++ + SS G ++ ++ +K I + + SS KAS
Sbjct: 732 ------ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS----KAS-------- 773
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
IT E R L T+ S+ S E L L EK + E S +
Sbjct: 774 -SITRELQGRELKLTNLQENLSEVSQV----KETLEKELQILKEKFAEASEEAVSVQRSM 828
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q T+ +L +++ L+++ EKL + +E F + ER EQL + EKL N + E +
Sbjct: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
Query: 452 K------------NEEPTTQEGKIIELEQKCTGILEQGRFEREKL----LNIQQQLTCSL 495
K N+E +E + EL+ K T E F ++ + + +Q +
Sbjct: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
Query: 496 RKVEEENQGALEMIKRLKEENEKL----NEFLELERHNNNMMAKTLEECRVTLEGLKMEN 551
+K EEE + E+ ++L + +K+ N+ EL+ ++T + L+ L+
Sbjct: 949 KKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ L+G +++ + +++ E + + K A+ +D +++ ++ +E +
Sbjct: 1006 LDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLAS 1062
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL---QEKASESDAEIKDMKETIFEL 668
++ AK++ + LKE E+L+++ L +K E EI+ +K+ +
Sbjct: 1063 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1122
Query: 669 EDQVEQHRAVKLHNNQLISEL------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 722
Q+ A++ N +L EL +S KLEE++S L QL + K+ + ++
Sbjct: 1123 SQQLS---ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1179
Query: 723 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 761
+A LQ ++ + + + E EL ++ ++ +NA
Sbjct: 1180 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1218
Score = 85.5 bits (210), Expect = 2e-16
Identities = 150/736 (20%), Positives = 281/736 (38%), Gaps = 106/736 (14%)
Query: 98 TTTKRTGIPAPREFSVTVSRERSVPRGPS-NPRKSVSSPTSSNTPTPTKHLRTPSTKPKQ 156
TT + A R T S S+ R PS + S+SS SS + P++ T +
Sbjct: 286 TTPAKAKANAVRRVMATTSA--SLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 157 ENEGGEKAALESQVRE-------LLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALG 209
+ AL+ ++E LLAE + +E+ + S + + +++ L +G D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ-- 401
Query: 210 PNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASH 269
+V M+ A + + L+ LEEE R +++ +E ++G
Sbjct: 402 -HVLELEAKMDQLRTMVEAADREKVEL---LNQLEEEKRKVEDLQFRVEEESITKGDLEV 457
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
S + E ++ E ++ + N + DV + S
Sbjct: 458 ATVSEKSRIMELEKDLALRV-----QEVAELRRRLESN------KPAGDVDMS-----LS 501
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
+ I++ ++ T + + + SL E EE H +
Sbjct: 502 LLQEISSLQEKLEVTRTDH------------------QREITSLKEHFGAREETHQKEIK 543
Query: 390 ELQATLQELSDQQQMVQ-ELTAENEKLVDE----KTILETSFHQHRERAEQLSQENEKLM 444
L ++LS + + ++ +L N++ D K+ LET+ H++ E+L K
Sbjct: 544 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-- 601
Query: 445 NLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQ 503
L E + E TQ K+ ++ + + + Q ER + L L KV +E +
Sbjct: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
Query: 504 GALEMIK---------RLKEENEKLNEFLELERH-------------------NNNMMAK 535
+LE I+ L E + LN+ E E N K
Sbjct: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK 721
Query: 536 TLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE 595
EE + L+ L+ + KS ++ +Q + A E+ + E+++ + ++A E
Sbjct: 722 ATEEKLLDLDALRKASSEGKSEMKKLRQ---QLEAAEKQIKHLEIEKNAESSKASSITRE 778
Query: 596 LSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESD 655
L EL+ L+ N + VS + +EK+ LKE K E + E+
Sbjct: 779 LQGRELKLTNLQEN--LSEVSQVKETLEKELQILKE--------------KFAEASEEAV 822
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
+ + M+ET+ +L + EQ + +L L K E K + E QL ++++
Sbjct: 823 SVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDEREEQLIKAKEKLE 881
Query: 716 EETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGR 775
+ E + D + + ND ++++ ++ KL + E + LQK + D+
Sbjct: 882 NDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE 941
Query: 776 VVTSRAAPPPVDEEPE 791
AA +E+ E
Sbjct: 942 QSQQEAAKKHEEEKKE 957
Score = 83.2 bits (204), Expect = 1e-15
Identities = 141/626 (22%), Positives = 273/626 (43%), Gaps = 102/626 (16%)
Query: 157 ENEGGEKAALESQVRELLAEAKAKD---SEINRLRSELKKYKEKRTLNAEGTDALGPNVD 213
+N + A E ++ +L A KA SE+ +LR +L+ EK+ + E + N +
Sbjct: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQIKHLE----IEKNAE 768
Query: 214 GTSVSPGDTEPMIRALEEKNKNFQKELSD-------LEEENRVLKEKLIYLEHSPNSEGA 266
+ S E ++ E K N Q+ LS+ LE+E ++LKEK + E
Sbjct: 769 SSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA----EASEEAV 822
Query: 267 ASHTGDSSCPTSITQ-ESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSSSDVTKAS 323
+ + Q E F N +SSD+++ ++N+ R + KA
Sbjct: 823 SVQRSMQETVNKLHQKEEQF-----NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 877
Query: 324 --LSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
L D ++ ++ + S+ L+ ++ + + V EL L K+ K
Sbjct: 878 EKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKE--------RDVEELQL-----KLTKAN 923
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENE---------KLVDEKTILETSFHQHRER 432
EN A LQ ++++++ + + Q+ A+ KL D + +ETS +Q +E
Sbjct: 924 EN----ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTT--QEGKIIELEQKCTGILEQ-----GRFEREKLL 485
+ + + +E ++N + T E K+ ++ +G+L++ + ++ K
Sbjct: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1039
Query: 486 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR--VT 543
+ + ++ +E L ++ K+ N KL L+ + NN + L + + +T
Sbjct: 1040 QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLT 1099
Query: 544 LEGLKMEN--GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 601
+E KME +++ Q QK+ + SA+++ E+ ++ E L +R E S +L
Sbjct: 1100 VENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVT----SHQKL 1153
Query: 602 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEI 658
+E N + LL +++ ++K+ + +A + +S TS L EK DAE+
Sbjct: 1154 EEERSVLNNQ------LLEMKKRESKFIKDADEEKASLQKSISITSALLTEK----DAEL 1203
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK--- 715
+ ++ + L E A LH+ ++ LES +KLE + +LE QLK +Q+
Sbjct: 1204 EKLRNEVTVLRG--ENASAKSLHS--VVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1259
Query: 716 -------EETEEWRRFQADLQTAVVV 734
+E E + Q D +V+V
Sbjct: 1260 GNTDTQADEDERAQESQIDFLNSVIV 1285
Score = 70.9 bits (172), Expect = 6e-12
Identities = 137/678 (20%), Positives = 267/678 (39%), Gaps = 105/678 (15%)
Query: 167 ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT--DALGPNVDGTSVSPGDTEP 224
+S++ EL + + E+ LR L+ K ++ + + + V+ D +
Sbjct: 463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR 522
Query: 225 MIRALEE----KNKNFQKELS-------DLEEENRVLKEKLIYLEHSPNSEGAASHTGDS 273
I +L+E + + QKE+ L +EN LK KL EH+ S
Sbjct: 523 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL---EHANKENSDVIALWKS 579
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 333
T+I ++E K + L T + +++ K + D++H
Sbjct: 580 KLETAIASHQQA-----------MEELKVSF-SKGLGTETAEFAEL-KTQIEKMRLDYQH 626
Query: 334 ITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEELQ 392
++ S + K + A E SL ++ K+ K E+ H E++
Sbjct: 627 EIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH---LVEME 683
Query: 393 ATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL---------SQENEKL 443
TL +L + + V+EL K ++ +++ Q + E+L S E +
Sbjct: 684 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 743
Query: 444 MNLLQERVKNEEPTTQEGKIIELEQ-----KCTGILEQGRFEREKLLNIQQQLTCSLRKV 498
M L+++++ E ++ K +E+E+ K + I + + KL N+Q+ L+ + +V
Sbjct: 744 MKKLRQQLEAAE---KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS-EVSQV 799
Query: 499 EEENQGALEMIKRLKEE------------NEKLNEFLELERHNNNMMAKTLEECRVTLEG 546
+E + L+++K E E +N+ L + NM++ LE+ R L
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQKEEQFNMLSSDLEKLRENLAD 858
Query: 547 LKM---ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQ 603
++ E + L K+K E E S + L E L E EL+
Sbjct: 859 MEAKFREKDEREEQLIKAKEKL-ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 604 ELLKANGEI----KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIK 659
+L KAN K + + K E+ + + + ++L R L++K S + +
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
Query: 660 DMK----------------------ETIFELEDQVEQHRAVKLHNNQLISELESSVIKLE 697
++K +T+ + ED+++ R N+ L+ ELE + +
Sbjct: 978 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE---ENSGLLQELEELRKQAD 1034
Query: 698 EQKS--DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTV------ 749
+ K+ E ++ + + KE+TE + QT + N++ + L+ V
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 750 KRKLLEEEEKNARLQKEL 767
K L E +K +KE+
Sbjct: 1095 KELLTVENQKMEEFRKEI 1112
Score = 60.1 bits (144), Expect = 1e-08
Identities = 121/591 (20%), Positives = 232/591 (39%), Gaps = 71/591 (12%)
Query: 123 RGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVREL-LAEAKAKD 181
R S+ KS K ++ + E+ E Q REL L +
Sbjct: 734 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 793
Query: 182 SEINRLRSELKK----YKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQ 237
SE+++++ L+K KEK +E ++ ++ T E L + +
Sbjct: 794 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 853
Query: 238 KELSDLE---EENRVLKEKLIYLEHSPNSEGAA--SHTGDSSCP-TSITQESSFGSPTGN 291
+ L+D+E E +E+LI + ++ A +GD+S T + E
Sbjct: 854 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 913
Query: 292 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
++ + K N + + L+ S + + S A E E R LS +
Sbjct: 914 ELQLKLT--KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKME 970
Query: 352 SS--KCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT 409
+S +C + + + E +Q +++ T ++L+ +E S Q ++EL
Sbjct: 971 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1030
Query: 410 AENEKLVDEKTI---LETSFHQHRERAEQLS------QENEKLMN----LLQERVKNEEP 456
+ +K +T ++ +E+ E L+ Q N KL N L + +KN E
Sbjct: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 457 TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE- 515
+ +++ +E + +E+ R E E L Q + L ++EEN E + R ++E
Sbjct: 1091 LNKSKELLTVENQK---MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
Query: 516 --NEKL--------NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH-------- 557
++KL N+ LE+++ + + EE + + + + L
Sbjct: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1207
Query: 558 -----LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 612
L+GE A +V QT ES +V+ LKV LEL E +++L ++G
Sbjct: 1208 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-----LELQLKENKRQLSSSSGNT 1262
Query: 613 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
+ ++D + + Q + L+ + LQ K + +++ M E
Sbjct: 1263 D------TQADED----ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 102 bits (253), Expect = 3e-21
Identities = 135/639 (21%), Positives = 271/639 (42%), Gaps = 85/639 (13%)
Query: 156 QENEGGEKAA----LESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPN 211
Q + E+AA +E+ +L+ K K++ + +RS+L K +++ + E D L
Sbjct: 667 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME--DTLN-K 723
Query: 212 VDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + + E L+ K K + + + + +EKL+ L+
Sbjct: 724 LQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD------------- 766
Query: 272 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 331
++ + SS G ++ ++ +K I + + SS KAS
Sbjct: 767 ------ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS----KAS-------- 808
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
IT E R L T+ S+ S E L L EK + E S +
Sbjct: 809 -SITRELQGRELKLTNLQENLSEVSQV----KETLEKELQILKEKFAEASEEAVSVQRSM 863
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q T+ +L +++ L+++ EKL + +E F + ER EQL + EKL N + E +
Sbjct: 864 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 452 K------------NEEPTTQEGKIIELEQKCTGILEQGRFEREKL----LNIQQQLTCSL 495
K N+E +E + EL+ K T E F ++ + + +Q +
Sbjct: 924 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
Query: 496 RKVEEENQGALEMIKRLKEENEKL----NEFLELERHNNNMMAKTLEECRVTLEGLKMEN 551
+K EEE + E+ ++L + +K+ N+ EL+ ++T + L+ L+
Sbjct: 984 KKHEEEKK---ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ L+G +++ + +++ E + + K A+ +D +++ ++ +E +
Sbjct: 1041 LDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDAMQI-MEQMTKEKTETLAS 1097
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL---QEKASESDAEIKDMKETIFEL 668
++ AK++ + LKE E+L+++ L +K E EI+ +K+ +
Sbjct: 1098 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1157
Query: 669 EDQVEQHRAVKLHNNQLISEL------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWR 722
Q+ A++ N +L EL +S KLEE++S L QL + K+ + ++
Sbjct: 1158 SQQLS---ALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDAD 1214
Query: 723 RFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 761
+A LQ ++ + + + E EL ++ ++ +NA
Sbjct: 1215 EEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENA 1253
Score = 89.4 bits (220), Expect = 2e-17
Identities = 163/747 (21%), Positives = 294/747 (39%), Gaps = 93/747 (12%)
Query: 98 TTTKRTGIPAPREFSVTVSRERSVPRGPS-NPRKSVSSPTSSNTPTPTKHLRTPSTKPKQ 156
TT + A R T S S+ R PS + S+SS SS + P++ T +
Sbjct: 286 TTPAKAKANAVRRVMATTSA--SLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 157 ENEGGEKAALESQVRE-------LLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDA-- 207
+ AL+ ++E LLAE + +E+ + S + + +++ L +G D
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
Query: 208 --LGPNVDG--TSVSPGDTEP--MIRALEEKNKNFQKELSDLEEENRVLK---EKLIYLE 258
L +D T V D E ++ LEE+ + + +L EE + K E LE
Sbjct: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLETQTKLE 462
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
H+ E S + + + +E S I E +K++ ALR +
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDL---ALRVQEVAELR 519
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
S P A D + + + + +SS + ++ + + SL E
Sbjct: 520 RRLESNKP-AGDVD--MSLSLLQEISSLQEKLEVTRTD---------HQREITSLKEHFG 567
Query: 379 KMEENHHSTAEELQATLQELSDQQQMVQ-ELTAENEKLVDE----KTILETSFHQHRERA 433
EE H + L ++LS + + ++ +L N++ D K+ LET+ H++
Sbjct: 568 AREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAM 627
Query: 434 EQLSQENEKLMNLLQERVKNEEPTTQEGKI-IELEQKCTGILEQGRFEREKLLNIQQQLT 492
E+L K L E + E TQ K+ ++ + + + Q ER + L
Sbjct: 628 EELKVSFSK--GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALR 685
Query: 493 CSLRKVEEENQGALEMIK---------RLKEENEKLNEFLELERH--------------- 528
L KV +E + +LE I+ L E + LN+ E E
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT 745
Query: 529 ----NNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEML 584
N K EE + L+ L+ + KS ++ +Q + A E+ + E+++
Sbjct: 746 KVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ---QLEAAEKQIKHLEIEKNA 802
Query: 585 KVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTS 644
+ ++A EL EL+ L+ N + VS + +EK+ LKE
Sbjct: 803 ESSKASSITRELQGRELKLTNLQEN--LSEVSQVKETLEKELQILKE------------- 847
Query: 645 LKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE 704
K E + E+ + + M+ET+ +L + EQ + +L L K E K + E
Sbjct: 848 -KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE-KDERE 905
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
QL ++++ + E + D + + ND ++++ ++ KL + E + LQ
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 965
Query: 765 KELGDVQGHGRVVTSRAAPPPVDEEPE 791
K + D+ AA +E+ E
Sbjct: 966 KSIEDMTVKAEQSQQEAAKKHEEEKKE 992
Score = 83.2 bits (204), Expect = 1e-15
Identities = 141/626 (22%), Positives = 273/626 (43%), Gaps = 102/626 (16%)
Query: 157 ENEGGEKAALESQVRELLAEAKAKD---SEINRLRSELKKYKEKRTLNAEGTDALGPNVD 213
+N + A E ++ +L A KA SE+ +LR +L+ EK+ + E + N +
Sbjct: 749 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEA-AEKQIKHLE----IEKNAE 803
Query: 214 GTSVSPGDTEPMIRALEEKNKNFQKELSD-------LEEENRVLKEKLIYLEHSPNSEGA 266
+ S E ++ E K N Q+ LS+ LE+E ++LKEK + E
Sbjct: 804 SSKASSITRE--LQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA----EASEEAV 857
Query: 267 ASHTGDSSCPTSITQ-ESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSSSDVTKAS 323
+ + Q E F N +SSD+++ ++N+ R + KA
Sbjct: 858 SVQRSMQETVNKLHQKEEQF-----NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAK 912
Query: 324 --LSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME 381
L D ++ ++ + S+ L+ ++ + + V EL L K+ K
Sbjct: 913 EKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKE--------RDVEELQL-----KLTKAN 958
Query: 382 ENHHSTAEELQATLQELSDQQQMVQELTAENE---------KLVDEKTILETSFHQHRER 432
EN A LQ ++++++ + + Q+ A+ KL D + +ETS +Q +E
Sbjct: 959 EN----ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 1014
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTT--QEGKIIELEQKCTGILEQ-----GRFEREKLL 485
+ + + +E ++N + T E K+ ++ +G+L++ + ++ K
Sbjct: 1015 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1074
Query: 486 NIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR--VT 543
+ + ++ +E L ++ K+ N KL L+ + NN + L + + +T
Sbjct: 1075 QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLT 1134
Query: 544 LEGLKMEN--GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNEL 601
+E KME +++ Q QK+ + SA+++ E+ ++ E L +R E S +L
Sbjct: 1135 VENQKMEEFRKEIETLKQAAAQKSQQLSALQE--ENVKLAEELGRSRDEVT----SHQKL 1188
Query: 602 RQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEI 658
+E N + LL +++ ++K+ + +A + +S TS L EK DAE+
Sbjct: 1189 EEERSVLNNQ------LLEMKKRESKFIKDADEEKASLQKSISITSALLTEK----DAEL 1238
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK--- 715
+ ++ + L E A LH+ ++ LES +KLE + +LE QLK +Q+
Sbjct: 1239 EKLRNEVTVLRG--ENASAKSLHS--VVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1294
Query: 716 -------EETEEWRRFQADLQTAVVV 734
+E E + Q D +V+V
Sbjct: 1295 GNTDTQADEDERAQESQIDFLNSVIV 1320
Score = 72.4 bits (176), Expect = 2e-12
Identities = 142/699 (20%), Positives = 277/699 (39%), Gaps = 107/699 (15%)
Query: 148 RTPSTKPKQENEGGEKAAL--ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT 205
+T + K ++E E A + +S++ EL + + E+ LR L+ K ++ +
Sbjct: 477 KTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLS 536
Query: 206 --DALGPNVDGTSVSPGDTEPMIRALEE----KNKNFQKELS-------DLEEENRVLKE 252
+ + V+ D + I +L+E + + QKE+ L +EN LK
Sbjct: 537 LLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKS 596
Query: 253 KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTS 312
KL EH+ S T+I ++E K + L T
Sbjct: 597 KL---EHANKENSDVIALWKSKLETAIASHQQA-----------MEELKVSF-SKGLGTE 641
Query: 313 GSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLA 371
+ +++ K + D++H ++ S + K + A E SL
Sbjct: 642 TAEFAEL-KTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLE 700
Query: 372 SLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE 431
++ K+ K E+ H E++ TL +L + + V+EL K ++ +++ Q +
Sbjct: 701 AIRSKLDKAEDQH---LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 432 RAEQL---------SQENEKLMNLLQERVKNEEPTTQEGKIIELEQ-----KCTGILEQG 477
E+L S E + M L+++++ E ++ K +E+E+ K + I +
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE---KQIKHLEIEKNAESSKASSITREL 814
Query: 478 RFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE------------NEKLNEFLEL 525
+ KL N+Q+ L+ + +V+E + L+++K E E +N+ L
Sbjct: 815 QGRELKLTNLQENLS-EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK-LHQ 872
Query: 526 ERHNNNMMAKTLEECRVTLEGLKM---ENGSLKSHLQGEKQKATEASAVEQTAESCEVQE 582
+ NM++ LE+ R L ++ E + L K+K E E S +
Sbjct: 873 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL-ENDIAEIMKMSGDNSS 931
Query: 583 MLKVARAEKDLLELSCNELRQELLKANGEI----KHVSSLLAKVEKDYSYLKEICDHQAE 638
L E L E EL+ +L KAN K + + K E+ + + + +
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 639 QLSRTSLKLQEKASESDAEIKDMK----------------------ETIFELEDQVEQHR 676
+L R L++K S + +++K +T+ + ED+++ R
Sbjct: 992 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR 1051
Query: 677 AVKLHNNQLISELESSVIKLEEQKS--DLERQLKTLTKQMKEETEEWRRFQADLQTAVVV 734
N+ L+ ELE + ++ K+ E ++ + + KE+TE + QT +
Sbjct: 1052 E---ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL 1108
Query: 735 ANDIKCEAQQELRTV------KRKLLEEEEKNARLQKEL 767
N++ + L+ V K L E +K +KE+
Sbjct: 1109 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEI 1147
Score = 60.1 bits (144), Expect = 1e-08
Identities = 121/591 (20%), Positives = 232/591 (39%), Gaps = 71/591 (12%)
Query: 123 RGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVREL-LAEAKAKD 181
R S+ KS K ++ + E+ E Q REL L +
Sbjct: 769 RKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL 828
Query: 182 SEINRLRSELKK----YKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQ 237
SE+++++ L+K KEK +E ++ ++ T E L + +
Sbjct: 829 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 888
Query: 238 KELSDLE---EENRVLKEKLIYLEHSPNSEGAA--SHTGDSSCP-TSITQESSFGSPTGN 291
+ L+D+E E +E+LI + ++ A +GD+S T + E
Sbjct: 889 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVE 948
Query: 292 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
++ + K N + + L+ S + + S A E E R LS +
Sbjct: 949 ELQLKLT--KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL-ERKLSDLEKKME 1005
Query: 352 SS--KCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT 409
+S +C + + + E +Q +++ T ++L+ +E S Q ++EL
Sbjct: 1006 TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELR 1065
Query: 410 AENEKLVDEKTI---LETSFHQHRERAEQLS------QENEKLMN----LLQERVKNEEP 456
+ +K +T ++ +E+ E L+ Q N KL N L + +KN E
Sbjct: 1066 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 457 TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEE- 515
+ +++ +E + +E+ R E E L Q + L ++EEN E + R ++E
Sbjct: 1126 LNKSKELLTVENQK---MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
Query: 516 --NEKL--------NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSH-------- 557
++KL N+ LE+++ + + EE + + + + L
Sbjct: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1242
Query: 558 -----LQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 612
L+GE A +V QT ES +V+ LKV LEL E +++L ++G
Sbjct: 1243 NEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN-----LELQLKENKRQLSSSSGNT 1297
Query: 613 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
+ ++D + + Q + L+ + LQ K + +++ M E
Sbjct: 1298 D------TQADED----ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 100 bits (250), Expect = 6e-21
Identities = 145/680 (21%), Positives = 290/680 (42%), Gaps = 94/680 (13%)
Query: 156 QENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGT 215
Q++ + ++ + ++L + KD +I L + L+K KE +L + + L +
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA- 555
Query: 216 SVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSC 275
G+T ++ L+EKN Q++++ L E+ + E H E +
Sbjct: 556 --GEGETA-VLNQLQEKNHTLQEQVTQLTEKLKNQSES-----HKQAQENLHDQVQEQKA 607
Query: 276 PTSITQESSFGSPTG-NQMSSDIDEYKKNIHGNALRTSGSS----SSDVTKASLSPDASD 330
Q+ T N+++S ++E K+ + ++ + S++ K + D +
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN 667
Query: 331 FEHI-TAETPSRPLSSTSNPF-------------KSSKCSTAGSSPNSVSE--LSLASLT 374
H+ TA+ + N K CS S E LSL T
Sbjct: 668 --HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 375 EK----IQKMEENHHSTAEELQATLQELSDQQQMVQEL----TAENEKLVDEKTILETSF 426
E+ I+K+E + + LQ+L Q+Q+ +L T +++L EK I+ ++
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 427 HQHRERAEQLSQENEKLMNLLQERV---KNEEPTTQEGKIIELE-----QKCTGILEQGR 478
++++E L +KL +E+ ++ E +QE KI E Q L++ +
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 479 FERE-----------KLLNIQQQLTCSLRKVEEENQ----GALEMIKRLKEENEKLNEFL 523
E+E KL + L S + E+ENQ L++ K KE +L +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 524 ELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHL--------QGEKQKATEASAVEQTA 575
E + K+LE+ + LK+E S++ L Q EK++ + +
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 576 ESCE--------VQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYS 627
+S E +Q LK+A +K LE N+L+Q+L +A E+ ++ ++ +Y
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELE---NKLQQQLTQAAQELAAEKEKISVLQNNYE 1022
Query: 628 YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS 687
+E +QL + + + ++K ++E + ++ + +R + N+LI
Sbjct: 1023 KSQETF----KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 688 ELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADL---QTAVVVANDIKCEAQQ 744
EL+++ LE+ + E+QL+ K +++ +E + +L ++ + +IKC ++
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 745 ELRTVKRKLLEEEEKNARLQ 764
E+ L EE K+ +L+
Sbjct: 1139 EITK-----LNEELKSHKLE 1153
Score = 93.2 bits (230), Expect = 1e-18
Identities = 135/618 (21%), Positives = 268/618 (43%), Gaps = 83/618 (13%)
Query: 168 SQVRELLAEAKAKDSEI-NRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMI 226
S++ E L E +E+ ++L ++++E++ L T L + D E ++
Sbjct: 463 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-------AQNDLEQVL 515
Query: 227 RALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFG 286
R + +K++ Q +LE + KE + LE A G+ T++ +
Sbjct: 516 RQIGDKDQKIQ----NLEALLQKSKENISLLEKEREDLYAKIQAGEGE--TAVLNQLQEK 569
Query: 287 SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSST 346
+ T + + + E KN + + + V + A+ ++ ET L+S
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 347 SNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE--NHHSTAEE-LQATLQELSDQQQ 403
N K K S + +EL L++ K + + NH TA+ LQ QEL+
Sbjct: 630 LNESKE-KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 688
Query: 404 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQ--ERVKNEEPTTQEG 461
+ ++TA+ + + + LE+ +++E+ L Q+ E+L ++ E E ++E
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 462 KIIELEQK--CTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR-------- 511
+ +L+Q+ LE E K L +++++ S R ++ ALE IK+
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEE 808
Query: 512 ---LKEENEKLNEFLELERHN-NNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATE 567
LK++ E L++ +++ NN + T+ E L+ +KME +L + L K K ++
Sbjct: 809 KQILKQDFETLSQETKIQHEELNNRIQTTVTE----LQKVKMEKEALMTELSTVKDKLSK 864
Query: 568 ASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQEL-LKANGEIKHVSSLLAKVEKDY 626
S + ++S +E K A DL E +C EL+ +L ++ +K L +EK+
Sbjct: 865 VSDSLKNSKSEFEKENQKGKAAILDL-EKTCKELKHQLQVQMENTLKEQKELKKSLEKE- 922
Query: 627 SYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI 686
+E + + E+ M+E + + ++ ++Q+
Sbjct: 923 ---------------------KEASHQLKLELNSMQEQLIQAQNTLKQNE---------- 951
Query: 687 SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQEL 746
K E+Q +LK ++Q K++ E Q +L+ AV+ +++ + QQ+L
Sbjct: 952 --------KEEQQLQGNINELKQSSEQKKKQIEA---LQGELKIAVLQKTELENKLQQQL 1000
Query: 747 RTVKRKLLEEEEKNARLQ 764
++L E+EK + LQ
Sbjct: 1001 TQAAQELAAEKEKISVLQ 1018
Score = 85.1 bits (209), Expect = 3e-16
Identities = 147/683 (21%), Positives = 286/683 (41%), Gaps = 84/683 (12%)
Query: 145 KHLRTPSTKPKQENEGGEK---------AALESQVRELLAEAKAKDSEINRLRSELKKYK 195
KH GGE L +V++L A K + L+ EL+KY+
Sbjct: 58 KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
Query: 196 EKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRV-LKEKL 254
+ A+ D L V +S E + + +N N K++ DL E+ L ++
Sbjct: 118 GLQQQEAK-PDGL---VTDSSAELQSLEQQLEEAQTENFNI-KQMKDLFEQKAAQLATEI 172
Query: 255 IYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGS 314
++ + E + + T +T+E N+ ++ I + K + L+ G
Sbjct: 173 ADIKSKYDEERSLREAAEQKV-TRLTEEL-------NKEATVIQDLKTEL----LQRPGI 220
Query: 315 SSSDVTKASLSPDASDFEHITAETP--SRPLSSTSNPFKSSKCSTAGSSPNSVSELS--- 369
V K L + +++T E S L +S S+ + SEL+
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 370 --LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE-NEKLVDEKTILETSF 426
+A +++QK++ + + ++ Q + L ++Q +L + NE+ V +K I + +
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI-QATL 339
Query: 427 HQHRERAEQLSQE---NEKLMNLLQERVKNEEPTTQEGK--IIELEQKCTGI------LE 475
HQ +QL +E ++ + + + TQ+ K + E+E K + L+
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 476 QGRFEREKL-LNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMA 534
Q R E+E+ L +Q ++ K+ E + E RLKE+ + +E L + +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 535 KTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLL 594
L L+ + L+ L KQ+ E A++Q+ + K+ A+ DL
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTA-------KLREAQNDL- 511
Query: 595 ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL-KEICDHQAE------------QLS 641
++ +++ + +I+++ +LL K +++ S L KE D A+ QL
Sbjct: 512 ----EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 642 RTSLKLQEKASESDAEIKDMKETIFE----LEDQVEQHRAVKLHNNQLISELESSVIKLE 697
+ LQE+ ++ ++K+ E+ + L DQV++ +A + LE+SV +L
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 698 EQKSDLERQLKTLTKQMKEETEEWRRFQA-------DLQTAVVVANDIKCEAQQELRTVK 750
Q ++ + ++ L Q+K +TE +A DLQ + A + + QQEL +
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 687
Query: 751 RKLLEEEEKNARLQKELGDVQGH 773
+L + K Q+ ++ H
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESH 710
Score = 82.8 bits (203), Expect = 2e-15
Identities = 143/660 (21%), Positives = 270/660 (40%), Gaps = 84/660 (12%)
Query: 146 HLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGT 205
HL T + + + E + +Q+ ++ A+ + K ++L S LK+YKEK + T
Sbjct: 668 HLDTAQNALQDKQQ--ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725
Query: 206 DALGPNV-----DGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHS 260
+ L + D V + + +++ N EL E ++ EK I
Sbjct: 726 EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV---- 781
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNI---HGNALRTSGSSSS 317
S S SI Q+ + + D + + H ++ +
Sbjct: 782 --SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 318 DVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKC-----STAGSSPNSVSELSLAS 372
++ K + +A E T + LS S+ K+SK + G + E +
Sbjct: 840 ELQKVKMEKEALMTELSTVKDK---LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE 896
Query: 373 LTEKIQKMEENHHSTAEELQATLQ-ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE 431
L ++Q EN +EL+ +L+ E Q+ EL + E+L+ + L+ + + ++
Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 432 ------RAEQLSQENEKLMNLLQERVKNE--EPTTQEGKIIELEQKCTGILEQGRFEREK 483
+Q S++ +K + LQ +K + T E K L+Q+ T ++ E+EK
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAAEKEK 1013
Query: 484 LLNIQ----------QQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 533
+ +Q +QL E E + +K ++E+ E L R+
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 534 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCE-VQEMLKVARAEKD 592
K ++E + L+ ++ + LQ E+ KA + E++ + E V E K+A E
Sbjct: 1074 NKLIQELKTAKATLEQDSAKKEQQLQ-ERCKALQDIQKEKSLKEKELVNEKSKLAEIE-- 1130
Query: 593 LLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS 652
E+ C + +E+ K N E+K S L + K+ + LK+ + L + L+LQ KA
Sbjct: 1131 --EIKCRQ-EKEITKLNEELK--SHKLESI-KEITNLKDA----KQLLIQQKLELQGKAD 1180
Query: 653 ESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTK 712
A ++ K L+DQV++ EL+ I E+++ L ++K
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEE----------EELKKEFI---EKEAKLHSEIKEKEV 1227
Query: 713 QMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
MK+ E +A L + N+ L TVK++ + + + L+K+ D++G
Sbjct: 1228 GMKKHEEN----EAKLTMQITALNE-------NLGTVKKEWQSSQRRVSELEKQTDDLRG 1276
Score = 75.1 bits (183), Expect = 3e-13
Identities = 121/635 (19%), Positives = 259/635 (40%), Gaps = 60/635 (9%)
Query: 159 EGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS 218
E EK +++E L+E + K L++E K+ +++R + L ++
Sbjct: 366 ELSEKGEATQKLKEELSEVETK---YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 219 PGDTEPMIRA----LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS----HT 270
+TE + L+E+ + ++L D E++ L+ KL LE + S H
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 271 GDSSCPTSITQESSFGSPTGN--QMSSDIDEYKKNIHGNALRTSGSSSSDVT--KASLSP 326
D + Q++ S T + +D+++ LR G + +A L
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQ--------VLRQIGDKDQKIQNLEALLQK 534
Query: 327 DASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHS 386
+ + E + +++ + +++ E + LTEK++ E+H
Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE-QVTQLTEKLKNQSESHKQ 593
Query: 387 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNL 446
E L +QE + Q+ E V+E L + ++ +E+ QL + + L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNE---LNSQLNESKEKVSQLDIQIKAKTEL 650
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
L T Q + L+ + E K+ Q+T K++++ +
Sbjct: 651 LLSA--EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA---KLQDKQEHCS 705
Query: 507 EMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 566
++ LKE EK +L LE+ + + + +LE +K LQ ++Q T
Sbjct: 706 QLESHLKEYKEK---YLSLEQKTEELEGQIKKLEADSLE-VKASKEQALQDLQQQRQLNT 761
Query: 567 EASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDY 626
+ E+ K EK+++ + R +L K + ++ + L K E++
Sbjct: 762 DLEL--------RATELSKQLEMEKEIV----SSTRLDLQKKSEALESIKQKLTKQEEE- 808
Query: 627 SYLKEICDHQAEQLSR-TSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQL 685
K+I E LS+ T ++ +E + + ++++ E E + + VK +++
Sbjct: 809 ---KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865
Query: 686 ISELESSVIKLEEQKS-------DLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
L++S + E++ DLE+ K L Q++ + E + Q +L+ ++ +
Sbjct: 866 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + EL +++ +L++ + + +KE +QG+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Score = 53.1 bits (126), Expect = 1e-06
Identities = 99/523 (18%), Positives = 215/523 (41%), Gaps = 69/523 (13%)
Query: 147 LRTPSTKPKQENEGGEKAAL--ESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 204
L+ ++ ++EN+ G+ A L E +EL + + + + + ELKK EK E
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK---EA 925
Query: 205 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 264
+ L ++ + ++ E++ + Q +++L++ + K+++ L+
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV--TKA 322
++ +TQ + + ++S + Y+K+ T SD ++
Sbjct: 986 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKS-----QETFKQLQSDFYGRES 1040
Query: 323 SLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEE 382
L D + + + LS S++ + G+ + EL A T +E+
Sbjct: 1041 ELLATRQDLKSVEEK-----LSLAQEDLISNR-NQIGNQNKLIQELKTAKAT-----LEQ 1089
Query: 383 NHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEK 442
+ ++LQ + L D Q+ E + + ++LV+EK+ L E++ EK
Sbjct: 1090 DSAKKEQQLQERCKALQDIQK---EKSLKEKELVNEKSKL--------AEIEEIKCRQEK 1138
Query: 443 LMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 502
+ L E +K+ + +E ++ T + + + ++ L +Q + VE+E
Sbjct: 1139 EITKLNEELKSHK--------LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190
Query: 503 QGALEMIKRLKEENEKL-NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 561
+ + ++K+E E+L EF+E E AK E +K + +K H + E
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKE-------AKLHSE-------IKEKEVGMKKHEENE 1236
Query: 562 KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 621
+ + +A + E L + E + +EL ++ GEI + + +
Sbjct: 1237 AKLTMQITA---------LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 622 VEKDYSYLKEIC---DHQAEQLSRTSLKLQEKASESDAEIKDM 661
+ + L E C + + E+L L+LQ K + A ++++
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 99.4 bits (246), Expect = 2e-20
Identities = 145/652 (22%), Positives = 267/652 (40%), Gaps = 91/652 (13%)
Query: 160 GGEKAALESQVREL---------LAEAKAKDSEINR--LRSELKKYKEKRTLNAEGTDAL 208
GGE A V+E LAE++A+ + + L+++L++ + L + L
Sbjct: 325 GGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKD---L 381
Query: 209 GPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS 268
+ + D + L K +K+ + ++ N+ L EKL LE E AA
Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441
Query: 269 HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSS-SSDVTKASLSPD 327
T D Q D+ + + + ++ SGS ++D + SL
Sbjct: 442 ETEDGEGL--------------QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGL 487
Query: 328 ASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHST 387
+ TPS P S+ +S + G SP +LA + HS
Sbjct: 488 SGQ------RTPSPPRRSSPGRGRSPR---RGPSPACSDSSTLALI-----------HSA 527
Query: 388 AEELQATLQELSDQQQMVQELTAENEKLVD----EKTILETSFHQHRERAEQLSQENEKL 443
+ Q +Q++ + + Q+L K + E+ LE + R++ + Q +E
Sbjct: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587
Query: 444 MNLLQE-RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEEN 502
+Q R NE + ++ + Q E+ R EREKL Q++L ++EEE
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 503 QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 562
+ A++ R++ E E+ + LE +++AK L E R L ++ L+
Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ------- 700
Query: 563 QKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
AE EV E L A A + LELS +LR E + +S+L +
Sbjct: 701 ------------AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESL 748
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 682
+D L + E+ +++L+ +++ +E +A + + EQ R +L
Sbjct: 749 AQDKLDLNRLVAQLEEE--KSALQGRQRQAEQEATVA-----------REEQERLEELRL 795
Query: 683 NQLISE--LESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
Q ++ LE S+ E+ + LE+QL TL + + E+ + L +
Sbjct: 796 EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
Query: 741 EAQQELRTVKRKLLEEE---EKNARLQKELGDVQGHGRVVTSRAAPPPVDEE 789
EAQ+++ ++R E+E +++A L +L + GR ++ A +++E
Sbjct: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKE 907
Score = 77.4 bits (189), Expect = 7e-14
Identities = 100/454 (22%), Positives = 195/454 (42%), Gaps = 63/454 (13%)
Query: 375 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
E +++ + A+E +L ++ + L+ E +L EK LE S + + +
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLA 921
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFERE----KLLNIQQQ 490
QL E+L Q + +E T G++ L Q+ E+ ++E KL+ +++
Sbjct: 922 QLEARREQLEAEGQALLLAKETLT--GELAGLRQQIIATQEKASLDKELMAQKLVQAERE 979
Query: 491 LTCSLRKVEEENQGALEMIKRLKE------ENEKLNEFLELERHNNNMMAKT---LEECR 541
SLR+ ++ L+ ++R KE E E+ +L+R ++A+ EE
Sbjct: 980 AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELS 1039
Query: 542 VTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAES--------------CEVQEMLKVA 587
+ L+ E + EKQ+A E+TA S E++ + A
Sbjct: 1040 EEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDA 1099
Query: 588 RAEKDLLELSCNELRQEL--LKANGE---IKHVSSL--LAKVEKDYSYLKEICDHQAEQL 640
++ ++ + N L EL L+A E H + L + +D ++ C +AE+L
Sbjct: 1100 QSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEEL 1159
Query: 641 SRTSLKLQEKASES-------------------DAEIKDMKETIFELEDQVEQHRAVKLH 681
RT L+L E A + + + ++ E L + ++ A++
Sbjct: 1160 -RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRS 1218
Query: 682 NNQL---ISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
N +L + + ES I L+ D E++L L + +E +L+T +
Sbjct: 1219 NEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE----AGELRTGLQEVERS 1274
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
+ EA++EL+ ++R++ + +N RL +EL ++QG
Sbjct: 1275 RLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/479 (20%), Positives = 190/479 (39%), Gaps = 65/479 (13%)
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEE- 390
E +A + +R L + ++ S G +EL+L E +++ E +T ++
Sbjct: 1545 ERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQE--ESVRRSERERRATLDQV 1602
Query: 391 ------LQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 444
LQAT EL Q+ + ++ A KL +K L+ R +L + L
Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLE 1662
Query: 445 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQ---QQLTCSLRKVEEE 501
LQ + +E + L+ + + Q K +Q ++L +L KVEE
Sbjct: 1663 GELQR--SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES 1720
Query: 502 NQGALEMIKRLKE--------------ENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 547
+ ++ L E +N L + L H+ ++ + L+ R L
Sbjct: 1721 EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 548 KMENGSLKSHLQ-----------------GEKQKATEASAVEQTAESCEVQEMLKVARAE 590
+ ++ SL +Q G+ Q+ E Q E+ + + K+ + E
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKL-QDE 1839
Query: 591 KDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEK 650
+ LL+ L++ L + E + V ++EKD L+ D ++ R L+ E
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLD----KVEREKLRSHED 1895
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 710
AE + T+ E ++ + + + I +LE+ V+ LE+ S + ++
Sbjct: 1896 TVRLSAEKGRLDRTLTGAELELAEAQ-------RQIQQLEAQVVVLEQSHSPAQLEVDAQ 1948
Query: 711 TKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK--NARLQKEL 767
+Q++ + E R A QT + EA++ + + LEE+ +LQ+EL
Sbjct: 1949 QQQLELQQEVERLRSAQAQT------ERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001
Score = 69.3 bits (168), Expect = 2e-11
Identities = 143/729 (19%), Positives = 276/729 (37%), Gaps = 85/729 (11%)
Query: 117 RERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAE 176
R S R PS PR+S S P+ ST + ++ + QV+++
Sbjct: 485 RGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKR---QLQVQDMRGR 541
Query: 177 AKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNF 236
+A + LR +L + +R E L DG + D + ++ L N+
Sbjct: 542 YEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELL 601
Query: 237 QKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSD 296
+E S+L +V +++ L AA + +E G ++ +
Sbjct: 602 SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQ-RDRLEEEQEDAVQDGARVRRE 660
Query: 297 ID---------EYKKNIHGNAL------RTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
++ E K+++ L + + D+ +A + A A
Sbjct: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
Query: 342 PLSSTSNPFKSSKCSTAGSSPNSVSE------LSLASLTEKI----------QKMEENHH 385
LS T + + + S ++++E L L L ++ Q+ E
Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780
Query: 386 STAEELQATLQELSDQQQMVQELTAENEKLVDE-KTILETSFHQHRERAEQLSQENEKLM 444
+ A E Q L+EL +Q++ ++ + ++ ++ + LE R QL ++ +L
Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Query: 445 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQG 504
L R + E +E Q+ LE+ E+E L L L E E +
Sbjct: 841 RQLSGREQELEQARREA------QRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT 894
Query: 505 ALEMIKRLKEENEKL-NEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 563
E RL+ E E L E++R + A+ E+ + L + +L L G +Q
Sbjct: 895 LSEEATRLRLEKEALEGSLFEVQRQLAQLEARR-EQLEAEGQALLLAKETLTGELAGLRQ 953
Query: 564 KA----------TEASAVEQTAESCEVQEMLKVARA--EKDL------LELSCNELRQEL 605
+ E A + E Q L+ RA E+DL E + EL E
Sbjct: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013
Query: 606 LKANGEI-KHVSSLLAKVEKDYSYLKE------------ICDHQAEQLSRTSLKLQEKAS 652
+ ++ + LLA++E + L E + ++E+ SLK EK +
Sbjct: 1014 AQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA 1073
Query: 653 ESDAEI---KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLE----- 704
S+ + + E+E Q ++ + + ++ L S + L Q+ +
Sbjct: 1074 LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Query: 705 --RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNAR 762
R+L+ + + ++ + R +L+T + + D + ++EL +RKL E +E
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV 1193
Query: 763 LQKELGDVQ 771
++E G+++
Sbjct: 1194 QRQEAGELR 1202
Score = 65.9 bits (159), Expect = 2e-10
Identities = 142/742 (19%), Positives = 280/742 (37%), Gaps = 69/742 (9%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
E++ L+ Q+ +L + ++ E+ + R E ++ E A +AL G +V
Sbjct: 828 ERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVA 887
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE---HSPNSEGAASHTGDSSCPTS 278
E R L E+ + E LE ++ +L LE +EG A
Sbjct: 888 AEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA---------LL 938
Query: 279 ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAET 338
+ +E+ G G + + K ++ + + +ASL + E +
Sbjct: 939 LAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE-DLQR 997
Query: 339 PSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQEL 398
R + ++ + EL EK + EE E + L
Sbjct: 998 LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057
Query: 399 SDQQQMVQ----ELTAENEKLVDEKTILET-SFHQHRER--AEQLSQENEKLMNLLQERV 451
S++QQ + E TA +EKL+ + L T S R++ A+ +++ +N L +
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 508
++ +E Q+ + EQ R +R+ L ++L LR +E+ G
Sbjct: 1118 RDLRAQREEAAAAHA-QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRE 1176
Query: 509 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
+ + + + E E++R + ++L E E L+ N L+S ++
Sbjct: 1177 LLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVK--------- 1227
Query: 569 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 628
AES + LK+A +K+ E R + K GE++ +
Sbjct: 1228 -----KAESERIS--LKLANEDKEQKLALLEEARTAVGKEAGELR-------------TG 1267
Query: 629 LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISE 688
L+E+ + + R +L+ + D+E + + EL+ ++ + + +
Sbjct: 1268 LQEV-ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLG 1326
Query: 689 LESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRT 748
L ++K E + ++L+ ++++E+ E+R + L ++ A + + R
Sbjct: 1327 LRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
Query: 749 VKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDA--AGRWPGVCV 806
++ KL + A L L +G + + + A V +++ + G+ +
Sbjct: 1387 LELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGL 1446
Query: 807 SRT-SPTP-PESATTVKSLIKSFDLGRPGGAGQNISVHKTPR-SPLSGIPVRTAPAAAVS 863
R SP P P + + G+G+ ++ T SP S P +P A S
Sbjct: 1447 GRAPSPAPRPVPGSPARD-------APAEGSGEGLNSPSTLECSPGSQPP---SPGPATS 1496
Query: 864 PMQRHSTYSSVRPASRGVTQRL 885
P +VR A R Q L
Sbjct: 1497 PASPDLDPEAVRGALREFLQEL 1518
Score = 42.0 bits (97), Expect = 0.003
Identities = 66/308 (21%), Positives = 121/308 (39%), Gaps = 34/308 (11%)
Query: 156 QENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGT 215
+E+EG AL +VR L + +N R + ++ T L +D
Sbjct: 1718 EESEG----ALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773
Query: 216 SVSPGDTEPMIRALEEKNKNFQKELSDLE----EENRVLKEKLIYLEHSPNSEGAASHTG 271
+ + +L E+ + + E++DLE E L++ L E AA +T
Sbjct: 1774 RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV 1833
Query: 272 DSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDF 331
+ GS + + ++ K+ + +ALR D + D +
Sbjct: 1834 QKLQDERRLLQERLGSL--QRALAQLEAEKREVERSALRLE----KDRVALRRTLDKVER 1887
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKME------ENHH 385
E + + + LS+ + +EL LA +IQ++E E H
Sbjct: 1888 EKLRSHEDTVRLSAEKGRLDRTLTG---------AELELAEAQRQIQQLEAQVVVLEQSH 1938
Query: 386 STAE-ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 444
S A+ E+ A Q+L QQ++ + +A+ + E+T LE HR+R L ++ L
Sbjct: 1939 SPAQLEVDAQQQQLELQQEVERLRSAQAQT---ERT-LEARERAHRQRVRGLEEQVSTLK 1994
Query: 445 NLLQERVK 452
LQ+ ++
Sbjct: 1995 GQLQQELR 2002
Score = 41.2 bits (95), Expect = 0.005
Identities = 40/200 (20%), Positives = 91/200 (45%), Gaps = 6/200 (3%)
Query: 579 EVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAE 638
E + L+ A+ E+D L + L ++L + E +S +++K + +E
Sbjct: 1513 EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDG 1572
Query: 639 QLSRTSLKL---QEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIK 695
+LS +L +E S+ E + + + LE ++ + + + IS+++++ K
Sbjct: 1573 RLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK 1632
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA---QQELRTVKRK 752
LE K L+ L + + + R + +LQ + + +D + +A Q + +++R+
Sbjct: 1633 LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQ 1692
Query: 753 LLEEEEKNARLQKELGDVQG 772
+ + E K LQ + + G
Sbjct: 1693 VADSEVKAGTLQLTVERLNG 1712
Score = 37.7 bits (86), Expect = 0.058
Identities = 51/282 (18%), Positives = 112/282 (39%), Gaps = 32/282 (11%)
Query: 446 LLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGA 505
L QE+ Q+ +I L I+ + + E + + SL ++EENQ
Sbjct: 27 LCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQ-- 84
Query: 506 LEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLE-GLKMENGSLKSHLQGEKQK 564
L++E ++ + L R + +A LE L++E G L++
Sbjct: 85 -----LLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ------- 132
Query: 565 ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK 624
E + + +S E++ L+ +A R++L + + L+ +++
Sbjct: 133 --EPRGLVR--QSVELRRQLQEEQAS----------YRRKLQAYQEGQQRQAQLVQRLQG 178
Query: 625 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 684
K+ C +QL S +L+++ +D++ + LE++ ++ ++ N
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238
Query: 685 LISELESSVIKLEEQKSDLERQLKTLT---KQMKEETEEWRR 723
L +L+ + + D+ + T K+++ WRR
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRR 280
Score = 35.8 bits (81), Expect = 0.22
Identities = 30/158 (18%), Positives = 74/158 (46%), Gaps = 26/158 (16%)
Query: 576 ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDH 635
E V+++L +RAE+D L + N + + L +A ++E E+
Sbjct: 89 ELSRVEDLLAQSRAERDELAIKYNAVSERLEQA-----------LRLEPG-----ELETQ 132
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIK 695
+ L R S++L+ + E A + +++ ++ + QL+ L+ +++
Sbjct: 133 EPRGLVRQSVELRRQLQEEQASYRR----------KLQAYQEGQQRQAQLVQRLQGKILQ 182
Query: 696 LEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 733
+++ S+LE+QL + +++++ DL++A++
Sbjct: 183 YKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
Score = 34.3 bits (77), Expect = 0.64
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 7/90 (7%)
Query: 165 ALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEP 224
+L+ QV + +A + RL L K +E +EG AL V G + + +
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEE-----SEG--ALRDKVRGLTEALAQSSA 1740
Query: 225 MIRALEEKNKNFQKELSDLEEENRVLKEKL 254
+ + +KN + QK L+ E + +VL+E+L
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERL 1770
>gi|19913396 smoothelin isoform b [Homo sapiens]
Length = 915
Score = 99.4 bits (246), Expect = 2e-20
Identities = 44/103 (42%), Positives = 67/103 (65%), Gaps = 1/103 (0%)
Query: 963 SKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRN 1022
S + LL WC+ KT+GY ++DI NFSSSWSDG+AFCAL+H + P Y +L+ Q +++N
Sbjct: 800 SIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQN 859
Query: 1023 LLLAFEAAESVGIKPS-LELSEMLYTDRPDWQSVMQYVAQIYK 1064
+AF +AE+ P L+ +M+ PDW+ V Y+ + Y+
Sbjct: 860 FEVAFSSAETHADCPQLLDTEDMVRLREPDWKCVYTYIQEFYR 902
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 97.1 bits (240), Expect = 8e-20
Identities = 137/627 (21%), Positives = 255/627 (40%), Gaps = 95/627 (15%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 273
+TE + ++E+ + + EL+ E + + L+EK++ L N SE + +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 333
C I + + ++ + ++ NA T+ + + L D D E
Sbjct: 907 RCEQLIKNKIQLEA----KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 334 ITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQA 393
A+ + K +T N E +A L E I K+ + + E Q
Sbjct: 963 TLAKV------------EKEKHATENKVKNLTEE--MAGLDETIAKLSKEKKALQETHQQ 1008
Query: 394 TLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNLLQER 450
TL +L ++ V LT KL + LE S Q ++ L + KL + L QE
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 451 VKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIK 510
+ E Q +L++K LE+ FE L++ K+E+E +++ K
Sbjct: 1069 TMDMENDKQ-----QLDEK----LEKKEFEISNLIS----------KIEDEQAVEIQLQK 1109
Query: 511 RLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQG 560
++KE E+L E +E ER + +++ LEE E L+ G+ + ++
Sbjct: 1110 KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQVEL 1166
Query: 561 EKQKATEASAVEQTAESCEVQEMLKVARAEK----DLLEL-----SCNELRQELLKANGE 611
K++ E + + E +Q VA K + EL + ++Q+L K E
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226
Query: 612 IK----HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFE 667
+K +SS + K L+++C +Q+S +L+ K E I D+
Sbjct: 1227 LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVS----ELKTKEEEQQRLINDLTAQRAR 1282
Query: 668 LEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ-------------- 713
L+ + ++ + L+S+L S +Q +L+ QL+ TK
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342
Query: 714 ---MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELGD 769
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L + L +
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1402
Query: 770 VQGHGRVVTSRAAPPPVDEEPESSEVD 796
+ H V ++ A ++ +EV+
Sbjct: 1403 AEEHVEAVNAKCASLEKTKQRLQNEVE 1429
Score = 80.9 bits (198), Expect = 6e-15
Identities = 134/632 (21%), Positives = 248/632 (39%), Gaps = 51/632 (8%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK A E++V+ L E D I +L E K +E + A V+ + +
Sbjct: 970 EKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK 1029
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E + LE + +K DLE R L+ L + S D +
Sbjct: 1030 LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFE 1089
Query: 282 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
S+ S ++ + +I KK A + +AS + + SR
Sbjct: 1090 ISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL-----SR 1144
Query: 342 PLSSTSNPFKSSKCSTAGSSP-NSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 399
L S + + +T+ N E L +++ H + L+ ++
Sbjct: 1145 ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 400 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 456
+ + + L +KL EK+ L+ AE +S+ EK+ L+++V +
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 457 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+E + + + Q+ E G + R+ L+ + L L + ++ + +E +K
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQ--LDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 514 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEAS 569
EE K L L+ RH+ +++ + EE + EG K+ LQ KA
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQ---EG--------KAELQRALSKANSEV 1371
Query: 570 AVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL 629
A +T + + R E+ LE + +L Q L +A ++ V++ A +EK L
Sbjct: 1372 AQWRTKYETDA-----IQRTEE--LEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 630 KEICDH---QAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHN 682
+ + E+ + L +K D + + K ET ELE ++ R++
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 683 NQLISELESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 739
++ + E S+ +LE + +L++++ LT+Q+ E ++ +L+ K
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH----ELEKIKKQVEQEK 1540
Query: 740 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
CE Q L + L EE K R+Q EL V+
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVK 1572
Score = 73.9 bits (180), Expect = 7e-13
Identities = 87/432 (20%), Positives = 177/432 (40%), Gaps = 62/432 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE Q T EL+ + +EL + L+ EK L+ +
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 436 LSQENEKLM-NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS 494
+ E+L+ N +Q K +E T + + E+ + T + E +L L +
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L KVE+E +K L EE L+E + + +T ++ TL+ L+ E +
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ---TLDDLQAEEDKV 1020
Query: 555 KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKH 614
K K V+ S E ++ L++ +L + K G++K
Sbjct: 1021 NILT---KAKTKLEQQVDDLEGSLEQEKKLRM-------------DLERAKRKLEGDLKL 1064
Query: 615 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETIFELEDQ 671
+E D L E + + ++S K++++ + + +IK+++ I EL ++
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEE 1124
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQM--------------KEE 717
+E RA S K E+Q+SDL R+L+ +++++ K+
Sbjct: 1125 IEAERA--------------SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKR 1170
Query: 718 TEEWRRFQADLQTAVVVAN-----------DIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
E+++ + DL+ A + D E +++ ++R + E++ + L+ E
Sbjct: 1171 EAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKME 1230
Query: 767 LGDVQGHGRVVT 778
D+ + ++
Sbjct: 1231 TDDLSSNAEAIS 1242
Score = 73.9 bits (180), Expect = 7e-13
Identities = 152/674 (22%), Positives = 278/674 (41%), Gaps = 102/674 (15%)
Query: 165 ALESQVRELLAEAKAKDSEINRL---RSELKKYKEKRTLNAEGTDALGPNVDGTS-VSPG 220
+LE QV EL + + + IN L R+ L+ + + + DAL + + S
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ 1313
Query: 221 DTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKEKLIYLEHSPNSEGAA 267
E + LEE+ K Q D + EE + K +L NSE A
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1373
Query: 268 SHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSSSSDVTKASL 324
T + T+E Q + +E+ + ++ +T ++V L
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 325 SPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH 384
+ S+ + R + +K T S E SL+ ++ K++ +
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESR--SLSTELFKVKNVY 1491
Query: 385 HSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTILETSFHQHRERAEQLSQENE 441
+ ++L+ +E + QQ + +LT AE K + H+ + +Q+ QE
Sbjct: 1492 EESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI----------HELEKIKKQVEQEKC 1541
Query: 442 KLMNLLQERVKNEEPTTQEGKIIELEQKCTGIL-EQGRFEREKLLNIQQQLTCSLRKVEE 500
++ L+E + E +EGKI+ ++ + + E R EK I Q R VE
Sbjct: 1542 EIQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVET 1599
Query: 501 -------ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGS 553
E + + ++ K+ LNE H N + A++L R T LK
Sbjct: 1600 MQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH 1659
Query: 554 LKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
L L+G++ + + VE+ A E++E+ A + E S QELL A+
Sbjct: 1660 LDDALRGQEDLKEQLAIVERRANLLQAEIEELW----ATLEQTERSRKIAEQELLDASER 1715
Query: 612 IKHV----SSLL---AKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASE--SDAEI---- 658
++ + +SL+ K+E D S L+ + E++ + S +EKA + +DA +
Sbjct: 1716 VQLLHTQNTSLINTKKKLENDVSQLQS----EVEEVIQESRNAEEKAKKAITDAAMMAEE 1771
Query: 659 ---------------KDMKETIFELEDQVEQHRAVKLH-NNQLISELESSVIKLE----- 697
K++++T+ +L+ ++++ + L + I +LE+ V +LE
Sbjct: 1772 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVEN 1831
Query: 698 EQKSDLE-----RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRK 752
EQK + E R+ + K++ +TEE R+ LQ D+ + Q ++++ KR+
Sbjct: 1832 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQ-------DLVDKLQAKVKSYKRQ 1884
Query: 753 LLE-EEEKNARLQK 765
E EE+ NA L K
Sbjct: 1885 AEEAEEQSNANLSK 1898
Score = 68.6 bits (166), Expect = 3e-11
Identities = 122/613 (19%), Positives = 243/613 (39%), Gaps = 101/613 (16%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
K E+E + L+ +++EL A + EI R+ K +++R+ + + + ++
Sbjct: 1096 KIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1155
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSS 274
G T + +++ FQK DLEE L+H DS
Sbjct: 1156 AG---GATSAQVELNKKREAEFQKLRRDLEEAT---------LQHEAMVAALRKKHADSM 1203
Query: 275 CPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHI 334
++ ID ++ K L + S+ +
Sbjct: 1204 A----------------ELGEQIDNLQR-----------------VKQKLEKEKSELKME 1230
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQAT 394
T + LSS + +K + E SL +++ +++ EE Q
Sbjct: 1231 TDD-----LSSNAEAISKAKGNL---------EKMCRSLEDQVSELKTKE----EEQQRL 1272
Query: 395 LQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNE 454
+ +L+ Q+ +Q E + +DEK L + + ++ + +Q+ E+L + L+E K +
Sbjct: 1273 INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS---TQQIEELKHQLEEETKAK 1329
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
+ C + EQ E+E +Q+ L+ + +V + R K
Sbjct: 1330 NALAHA--LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW---------RTKY 1378
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASA-VEQ 573
E + + ELE + A+ L+E +E + + SL+ Q + + + VE+
Sbjct: 1379 ETDAIQRTEELEEAKKKL-AQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1437
Query: 574 TAESCEVQEMLKVARAEKDLLELS--CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKE 631
+ +C + K +K L E E + EL + E + +S+ L KV+ Y +E
Sbjct: 1438 SNAACAALDK-KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY---EE 1493
Query: 632 ICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELES 691
D Q E L R + LQ++ S+ +I + + I ELE +Q K + E E+
Sbjct: 1494 SLD-QLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552
Query: 692 SV-----------IKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
S+ ++L + KS+++R++ + EE ++ +R + + D +
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKI----AEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 741 EAQQELRTVKRKL 753
++ + VK+K+
Sbjct: 1609 RSRNDALRVKKKM 1621
Score = 51.6 bits (122), Expect = 4e-06
Identities = 115/599 (19%), Positives = 223/599 (37%), Gaps = 68/599 (11%)
Query: 124 GPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDS 182
G + ++++S S TK+ + ++ E +K A Q E EA AK +
Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415
Query: 183 EINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSD 242
+ + + L+ E L+ E ++A AL++K +NF K LS+
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAA-----------------CAALDKKQRNFDKVLSE 1458
Query: 243 LEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN--QMSSDIDEY 300
+++ + +L + S + S+ Q + N Q SD+ E
Sbjct: 1459 WKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQ 1518
Query: 301 KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
+ G ++ K + E I A S K + +
Sbjct: 1519 --------IAEGGKQIHELEKIKKQVEQEKCE-IQAALEEAEASLEHEEGKILRIQLELN 1569
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE--------LSDQQQMVQELTAEN 412
S + +A E+I +++ NH E +Q+TL L +++M +L
Sbjct: 1570 QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629
Query: 413 EKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL--QERVKNEEPTTQE-GKIIELE-Q 468
+L + S +R L + L + L QE +K + + +++ E +
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIE 1689
Query: 469 KCTGILEQGRFEREKLLNIQQQLTCSLRK--VEEENQGALEMIKRLKEENEKLN----EF 522
+ LEQ ER + + Q+ L S R + +N + K+L+ + +L E
Sbjct: 1690 ELWATLEQT--ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747
Query: 523 LELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQE 582
++ R+ K + + + E LK E + +HL E+ K V+ + E
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNLEQTVKDLQHRLDEAE 1804
Query: 583 MLKVARAEKDLLELSC----------NELRQELLKANGEIKH---VSSLLAKVEKDYSY- 628
L + +K + +L NE ++ G KH V L + E+D
Sbjct: 1805 QLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNV 1864
Query: 629 --LKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQL 685
L+++ D ++ + +E +S+A + ++ ELE+ E+ + N+L
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKL 1923
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 96.7 bits (239), Expect = 1e-19
Identities = 144/612 (23%), Positives = 252/612 (41%), Gaps = 65/612 (10%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 273
+TE + ++E+ + ++EL+ E + + L+EK++ L N +E A +
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 274 SC----PTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
C T I E+ T + + D +E NA T+ + + L D
Sbjct: 908 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 959
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E A+ + K +T N E +A L E I K+ + + E
Sbjct: 960 DLELTLAKV------------EKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKALQE 1005
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
Q TL +L ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1006 AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKL 1065
Query: 447 LQERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQ-----QQLTCSLRKVE 499
QE + E Q+ K+ + E + + + QG+ E E+ L IQ ++L + ++E
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNL--QGKIEDEQALAIQLQKKIKELQARIEELE 1123
Query: 500 EENQGALEMIKRLKEENEKLNEFLELERHNNNM-------MAKTLEECRVTLEGLKMENG 552
EE + E R K E ++ + ELE + + A+ + E KM
Sbjct: 1124 EEIEA--ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 553 SLKSHLQGEKQKATEASAVEQTAES-CEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+S LQ E AT A+ ++ A+S E+ E + + K LE +EL+ E+
Sbjct: 1182 LEESTLQHE---ATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASN 1238
Query: 612 IKHVSSLLAKVEKDYSYLKEICDH---QAEQLSRTSLKLQEKASESDAEIKDMKETIFEL 668
++ VS A EK L++ + E+ R +L + + E + + E
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298
Query: 669 EDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---MKEETEEWRRFQ 725
+ V Q K Q I EL+ + + + KS L L++ ++E+ EE + +
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358
Query: 726 ADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELGDVQGHGRVVTSRAAPP 784
A+LQ + AN + + + T + EE EE +L + L D + H V S+ A
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418
Query: 785 PVDEEPESSEVD 796
++ +EV+
Sbjct: 1419 EKTKQRLQNEVE 1430
Score = 78.2 bits (191), Expect = 4e-14
Identities = 95/405 (23%), Positives = 177/405 (43%), Gaps = 58/405 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE + T +EL+ + +EL + L+ EK L+ Q + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEADA 901
Query: 436 LSQENEKLMNLLQERVKNE----EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQL 491
L+ E+ L++ +++ E E T + E+ + T + E +L L
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 492 TCSLRKVEEENQGALEMIKRLKEENEKLNEFL-ELERHNNNMMAKTLEEC-RVTLEGLKM 549
+L KVE+E +K L EE L+E + +L + K L+E + TL+ L+M
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK-----KALQEAHQQTLDDLQM 1016
Query: 550 ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKAN 609
E + + + + + + +E + E EK L C +L + K
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQ------------EKKL----CMDLERAKRKLE 1060
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEK---ASESDAEIKDMKETIF 666
G++K E D L E + ++S K++++ A + +IK+++ I
Sbjct: 1061 GDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE 1120
Query: 667 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQA 726
ELE+++E RA S K E+Q+SDL R+L+ ++++++E A
Sbjct: 1121 ELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE---------A 1157
Query: 727 DLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Score = 70.1 bits (170), Expect = 1e-11
Identities = 137/719 (19%), Positives = 279/719 (38%), Gaps = 91/719 (12%)
Query: 139 NTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
N K + + K E+E L+ +++EL A + + EI R+ K +++R
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
+ + + + ++ G T I +++ FQK DLEE L+
Sbjct: 1141 SDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDLEEST---------LQ 1188
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNA--LRTSGSSS 316
H + DS + ++ ++ + E K I+ A + T +
Sbjct: 1189 HEATAAALRKKHADS--VAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAK 1246
Query: 317 SDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEK 376
++ K + + E T E + L + + K+ + +G + E ++ +
Sbjct: 1247 ANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKD--AMVSQ 1304
Query: 377 IQKMEENHHSTAEELQATLQE---------------------LSDQQQMVQELTAE---- 411
+ + ++ EEL+ L+E L +Q + QE AE
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRG 1364
Query: 412 ----NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELE 467
N ++ +T ET Q R E+L + +KL LQ+ ++ E + +E
Sbjct: 1365 MSKANSEVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 468 QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELER 527
+ ++ + E E L+ ++ + ++++ + +++ K++ E+ LE +
Sbjct: 1422 K------QRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQ 1475
Query: 528 HNNNMMAKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV 580
+ ++ L EE LE LK EN +LQ E TE A E E+
Sbjct: 1476 KESRSLSTELFKVKNAYEESLDHLETLKREN----KNLQQEISDLTEQIA-EGGKHIHEL 1530
Query: 581 QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQL 640
+++ K EK L+ S E L G+I + L +V+ + D + +QL
Sbjct: 1531 EKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590
Query: 641 SRTSLKLQEK-ASESDAEIKDMKETI---FELEDQVEQHRAVKLHNNQLISE-------- 688
R L++ E S DAEI+ + + ++E + + H N+ +E
Sbjct: 1591 KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNT 1650
Query: 689 ---LESSVIKLEEQ---KSDLERQLKTLTKQ---MKEETEEWRRFQADLQTAVVVANDIK 739
L+ + + L++ + DL+ QL + ++ M+ E EE R + +A
Sbjct: 1651 QGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQEL 1710
Query: 740 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAA 798
+A + ++ + + +L+ ++ +QG + A +E+ + + DAA
Sbjct: 1711 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR--NAEEKAKKAITDAA 1767
Score = 64.3 bits (155), Expect = 6e-10
Identities = 141/702 (20%), Positives = 265/702 (37%), Gaps = 115/702 (16%)
Query: 163 KAALESQVREL---LAEAKAKDSEINRLRSELKKYKEKRTLNA-------EGTDALGPNV 212
KA E R L L+E K K+ E RL +EL K + + + DA+ +
Sbjct: 1246 KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL 1305
Query: 213 D-GTSVSPGDTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKEKLIYLE 258
G E + R LEE+ K Q D + EE + K +L
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSS 315
NSE A T + T+E Q D +E+ + ++ +T
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL 1425
Query: 316 SSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE 375
++V + + S+ I + R +K T S E SL+
Sbjct: 1426 QNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESR--SLST 1483
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE--------------NEKLVDEKTI 421
++ K++ + + + L+ +E + QQ + +LT + ++L EK+
Sbjct: 1484 ELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 422 LETSFHQHRERAEQLSQENEKLMNLLQE--RVKNEEPTTQEGKIIELEQ----------K 469
L+TS E L E K++ + E +VK+E K EL+Q
Sbjct: 1544 LQTSLE---EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 470 CTGILEQGRFEREKLLNIQQQLTCSLRKVEEE----NQGALEMIKRLKEEN--------- 516
L+ R L I++++ L ++E + N+ A E ++ L+
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLH 1660
Query: 517 --------EKLNEFLELERHNNNMMAKTLEECRVTLE----GLKMENGSL---------- 554
+ L E L + N+M +EE R +LE G KM L
Sbjct: 1661 LDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLL 1720
Query: 555 ----KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANG 610
S + +K+ T+ S ++ E + +A+K + + + + +EL K
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAM--MAEELKKEQD 1778
Query: 611 EIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESDAEIKDMKETI 665
H+ + +E+ L+ D +AEQL+ + KL+ + E ++E++ ++
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELESEVESEQKHN 1837
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE----- 720
E + +H E ++++L++ L+ ++K +Q +E E+
Sbjct: 1838 VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897
Query: 721 --WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 757
+R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1898 AKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 50.8 bits (120), Expect = 7e-06
Identities = 114/615 (18%), Positives = 243/615 (39%), Gaps = 73/615 (11%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++ +S S TK+ + ++ E +K A Q E EA +K + + +
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E ++ E ++A +D + + ++ ++K + Q EL ++E+
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQ---RNFDKVLAEWKQKYEETQAELEASQKES 1478
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGN 307
R L +L ++++ E + H ++ +E+ + ++ I E K+IH
Sbjct: 1479 RSLSTELFKVKNA--YEESLDHL------ETLKRENKNLQQEISDLTEQIAEGGKHIH-- 1528
Query: 308 ALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSE 367
+ K L + S+ + E + S K + + S +
Sbjct: 1529 --------ELEKVKKQLDHEKSELQTSLEEAEA---SLEHEEGKILRIQLELNQVKSEID 1577
Query: 368 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 427
+A E++ +++ NH E +Q+TL + + + E ++E I H
Sbjct: 1578 RKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLN--H 1635
Query: 428 QHRERAEQLSQENEKLMNL------LQERVKNEEPTTQEGKIIELE--------QKCTGI 473
+R+ AE L L L + ++ ++ ++ ++E ++
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRAS 1695
Query: 474 LEQGRFEREKLLNIQQQLTCSLRK--VEEENQGALEMIKRLKEE----NEKLNEFLELER 527
LE R ER + + Q+ L S R + +N + K+L+ + ++ + ++ R
Sbjct: 1696 LE--RTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753
Query: 528 HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEV------Q 581
+ K + + + E LK E + +HL+ K+ +EQT + ++ Q
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN------MEQTVKDLQLRLDEAEQ 1806
Query: 582 EMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS 641
LK + + LE EL E+ E KH + + K +KE+ +Q E+
Sbjct: 1807 LALKGGKKQIQKLEARVRELESEV---ESEQKHNVEAVKGLRKHERRVKELT-YQTEEDR 1862
Query: 642 RTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKS 701
+ L+LQ+ + ++K K E E+Q + A +L+ + + +E+
Sbjct: 1863 KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLA-------KFRKLQHELEEAKERAD 1915
Query: 702 DLERQLKTLTKQMKE 716
E Q+ L + +E
Sbjct: 1916 IAESQVNKLRVKSRE 1930
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 96.7 bits (239), Expect = 1e-19
Identities = 118/516 (22%), Positives = 209/516 (40%), Gaps = 100/516 (19%)
Query: 561 EKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVS---- 616
EK A + + E E+ + E+ ++ E E + EL K +GE + +
Sbjct: 72 EKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE----DAEAELKKEDGEKEETTVGSQ 127
Query: 617 SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHR 676
+ + E+ S KE AE+ T ++KA E +A+ + ++ D+ E
Sbjct: 128 EMTGRKEETKSEPKE-----AEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
Query: 677 AVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVAN 736
V+ + + S+ E+ + ++ E + K ++ K E+++ VV +
Sbjct: 183 TVEEEDAKTASQEETG----QRKECSTEPKEKATDEEAKAESQK-----------AVVED 227
Query: 737 DIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 796
+ K E ++ + K +EE +A+ + E + G P +E+ + E +
Sbjct: 228 EAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGS---------PSEEQEQDVEKE 278
Query: 797 AAGRWPGVCVSRTSPTP-PESATTVKSLIKSFDLGRPGGAGQNISVHKT-PRSPLSGIPV 854
G G V +SP PES P G G N+S P SG
Sbjct: 279 PEG---GAGVIPSSPEEWPES---------------PTGEGHNLSTDGLGPDCVASG--- 317
Query: 855 RTAPAAAVS-----PMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRTETLKPDPHL 909
+T+P+A+ S P + SS + +R+ P P + R +
Sbjct: 318 QTSPSASESSPSDVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVD----- 372
Query: 910 RKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREYGGSKRNALL 969
+ P+ F +T+ A+ G +N LL
Sbjct: 373 ----KFGGAASGPTALFRNTKAAGAAI-------------------------GGVKNMLL 403
Query: 970 KWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEA 1029
+WC+ T+ Y ++DI NFSSSWS G+AFCAL+H + P Y EL+ +++ N LAF
Sbjct: 404 EWCRAMTKKYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPAKRRHNFTLAFST 463
Query: 1030 AESVG-IKPSLELSEMLYTDRPDWQSVMQYVAQIYK 1064
AE + L++ +M+ PD + V Y+ ++Y+
Sbjct: 464 AEKLADCAQLLDVDDMVRLAVPDSKCVYTYIQELYR 499
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 96.3 bits (238), Expect = 1e-19
Identities = 139/630 (22%), Positives = 255/630 (40%), Gaps = 101/630 (16%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-----------SEGAASH 269
+TE + ++E+ + ++EL+ E + + L+EK++ L N S A
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 908 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 959
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 960 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1012
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1013 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKL 1065
Query: 447 LQERVKNEEPTTQ--EGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQG 504
QE + E Q + K+ + E + +G+ Q + E E+ L +Q Q
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGL--QSKIEDEQALGMQLQ-------------- 1109
Query: 505 ALEMIKRLKEENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSH 557
+ IK L+ E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1110 --KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSAQ 1164
Query: 558 LQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQE 604
++ K++ E + + E +Q A K D L+ +L +E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 664
+ EI ++S + V K L+++C +QLS +++ K E I D+
Sbjct: 1225 KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS----EIKTKEEEQQRLINDLTAQ 1280
Query: 665 IFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ----------- 713
L+ + ++ + L+S+L +Q +L+RQL+ K
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340
Query: 714 ------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKE 766
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400
Query: 767 LGDVQGHGRVVTSRAAPPPVDEEPESSEVD 796
L D + H V ++ A ++ +EV+
Sbjct: 1401 LQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430
Score = 78.6 bits (192), Expect = 3e-14
Identities = 153/704 (21%), Positives = 288/704 (40%), Gaps = 115/704 (16%)
Query: 163 KAALESQVREL---LAEAKAKDSEINRLRSELKKYKEK-RTLNAEGTDALGPNVDGTSVS 218
K LE R L L+E K K+ E RL ++L + + +T + E + L S
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 219 PGDTEPMIRALEEKNKNFQKE--------------------LSDLEEENRVLKEKLIYLE 258
+ + +EE + ++E L + EE + K +L
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNAL---RTSGSS 315
NSE A T + T+E Q D +E+ + ++ +T
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL 1425
Query: 316 SSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTE 375
++V + + ++ + R +K KC + + S+ SL+
Sbjct: 1426 QNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQ-KCEETHAELEA-SQKESRSLST 1483
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTILETSFHQHRER 432
++ K++ + + ++L+ +E + QQ + +LT AE K + H+ +
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRI----------HELEKI 1533
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGIL-EQGRFEREKLLNIQQQL 491
+Q+ QE +L L+E + E +EGKI+ ++ + + E R EK I Q
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMK 1591
Query: 492 TCSLRKVEE-------ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTL 544
+R VE E + + I+ K+ LNE H N M A+ L R T
Sbjct: 1592 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1651
Query: 545 EGLKMENGSLKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEKDLLELSCNELR 602
LK L L+ ++ + + VE+ A E++E+ RA + E S
Sbjct: 1652 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEEL----RATLEQTERSRKIAE 1707
Query: 603 QELLKANGEIKHV----SSLL---AKVEKDYSYLK-EICD-----HQAEQLSRTSL---- 645
QELL A+ ++ + +SL+ K+E D S ++ E+ D AE+ ++ ++
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAA 1767
Query: 646 -------KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH-NNQLISELESSVIKLE 697
K Q+ ++ + K++++T+ +L+ ++++ + L + I +LE+ V +LE
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE 1827
Query: 698 -----EQKSDL---------ERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQ 743
EQK ++ ER++K LT Q +E+ + R Q D+ + Q
Sbjct: 1828 GEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQ-----------DLVDKLQ 1876
Query: 744 QELRTVKRKLLEEEE-------KNARLQKELGDVQGHGRVVTSR 780
++++ KR+ E EE K R+Q EL + + + S+
Sbjct: 1877 AKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQ 1920
Score = 74.3 bits (181), Expect = 6e-13
Identities = 94/406 (23%), Positives = 176/406 (43%), Gaps = 60/406 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE + T +EL+ + +EL + L+ EK L+ Q + A+
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL---QVQAEADS 901
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 902 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 944
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 945 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 609
LQ Q+ + E+ + + +K+ + DL LE ++R +L +A
Sbjct: 1001 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKIRMDLERAKRKL 1059
Query: 610 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 665
G++K +E D L E + ++S K++++ + + +IK+++ I
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 725
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1120 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1156
Query: 726 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Score = 74.3 bits (181), Expect = 6e-13
Identities = 138/646 (21%), Positives = 261/646 (40%), Gaps = 102/646 (15%)
Query: 145 KHLRTPSTKPKQENEGGEKAALESQV------RELLAEAKAKDSEINRLRSELKKYKEKR 198
K +R + K++ EG K A ES + ++L + K K+ E++ L+S K ++++
Sbjct: 1046 KKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQS---KIEDEQ 1102
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1103 ALGMQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1154
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ GA S + + +E+ F +M D++E A +
Sbjct: 1155 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1203
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL--SLASLTEK 376
V A L + + + + L + K + S+ +VS+ +L +
Sbjct: 1204 V--AELGEQIDNLQRV-----KQKLEKEKSEMKM-EIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 436
++ + EE Q + +L+ Q+ +Q + E + +DEK L + + ++
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA---F 1312
Query: 437 SQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 496
+Q+ E+L L+E +K + + C + EQ E+E +Q+ ++ +
Sbjct: 1313 TQQIEELKRQLEEEIKAKSALAHA--LQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 497 KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
+V + R K E + + ELE + A+ L++ +E + + SL+
Sbjct: 1371 EVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQDAEEHVEAVNAKCASLEK 1420
Query: 557 HLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQELLKANGEIK 613
Q + + + VE+T +C + K +K L E C E EL + E +
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAELEASQKESR 1479
Query: 614 HVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVE 673
+S+ L K++ Y +E D Q E L R + LQ+ EI D+ E I E
Sbjct: 1480 SLSTELFKIKNAY---EESLD-QLETLKRENKNLQQ-------EISDLTEQIAE------ 1522
Query: 674 QHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVV 733
+ I ELE ++E++KS+L+ L+ ++ E + R Q +L
Sbjct: 1523 --------GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLEL----- 1569
Query: 734 VANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTS 779
N +K E V RK+ E++E+ ++++ H R+V S
Sbjct: 1570 --NQVKSE-------VDRKIAEKDEEIDQMKR------NHIRIVES 1600
Score = 70.9 bits (172), Expect = 6e-12
Identities = 135/716 (18%), Positives = 279/716 (38%), Gaps = 97/716 (13%)
Query: 145 KHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 204
K + K E+E L+ +++EL A + + EI R+ K +++R+ +
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1146
Query: 205 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 264
+ + ++ G T I +++ FQK DLEE L+H +
Sbjct: 1147 LEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDLEEAT---------LQHEATAA 1194
Query: 265 GAASHTGDSSCP-----TSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV 319
DS ++ + ++M +ID+ N + T + ++
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN-----METVSKAKGNL 1249
Query: 320 TKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQK 379
K + + E T E + L + ++ + +G + E +L ++ +
Sbjct: 1250 EKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD--TLVSQLSR 1307
Query: 380 MEENHHSTAEELQATLQE---------------------LSDQQQMVQELTAE------- 411
++ EEL+ L+E L +Q + QE AE
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
Query: 412 -NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKC 470
N ++ +T ET Q R E+L + +KL LQ+ ++ E K LE+
Sbjct: 1368 ANSEVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQDAEEHVEAV--NAKCASLEK-- 1420
Query: 471 TGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNN 530
++ + E E L+ ++ + ++++ + +++ K++ E+ + LE + +
Sbjct: 1421 --TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 531 NMMAKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEM 583
++ L EE LE LK EN +LQ E TE A E E++++
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKREN----KNLQQEISDLTEQIA-EGGKRIHELEKI 1533
Query: 584 LKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRT 643
K EK L+ + E L G+I + L +V+ + D + +Q+ R
Sbjct: 1534 KKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN 1593
Query: 644 SLKLQEK-ASESDAEIKDMKETI---FELEDQVEQHRAVKLHNNQLISE----------- 688
+++ E S DAEI+ + I ++E + + H N++ +E
Sbjct: 1594 HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAI 1653
Query: 689 LESSVIKLEE---QKSDLERQLKTLTKQ---MKEETEEWRRFQADLQTAVVVANDIKCEA 742
L+ + + L++ + DL+ QL + ++ ++ E EE R + + +A +A
Sbjct: 1654 LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1713
Query: 743 QQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAA 798
+ ++ + + +L+ ++ +QG + A +E+ + + DAA
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEAR--NAEEKAKKAITDAA 1767
Score = 64.3 bits (155), Expect = 6e-10
Identities = 150/691 (21%), Positives = 271/691 (39%), Gaps = 115/691 (16%)
Query: 163 KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDT 222
K LE++++E+ A+ ++ EIN +EL +KR L E ++ L ++D ++
Sbjct: 916 KIQLEAKIKEVTERAEDEE-EIN---AELTA--KKRKLEDECSE-LKKDIDDLELTLAKV 968
Query: 223 EPMIRALEEKNKNFQKELSDLEEE-NRVLKEKLIYLE-HSPNSEG--AASHTGDSSCPTS 278
E A E K KN +E++ L+E ++ KEK E H + A ++
Sbjct: 969 EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK 1028
Query: 279 ITQESSFGSPTGN-----QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPD----AS 329
I E G+ ++ D++ K+ + G+ L+ + S+ D+ D
Sbjct: 1029 IKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD-LKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 330 DF----------------------------------EHITAETPSR-----PLSSTSNPF 350
+F E I AE SR S S
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 351 K--SSKCSTAGSSPNSVSELSLASLTEKIQKMEEN-------HHSTAEELQA----TLQE 397
+ S + AG + ++ E++ E QKM + H +TA L+ ++ E
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAE-FQKMRRDLEEATLQHEATAATLRKKHADSVAE 1206
Query: 398 LSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQER---VKNE 454
L +Q +Q + + EK E + + E + EK+ L+++ +K +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266
Query: 455 EPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
E Q Q+ E G + R+ L+ + L L + ++ +E +KR E
Sbjct: 1267 EEEQQRLINDLTAQRARLQTESGEYSRQ--LDEKDTLVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 515 ENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASA 570
E K L L+ RH+ +++ + E E K+ LQ KA A
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYE-----------EEQEAKAELQRAMSKANSEVA 1373
Query: 571 VEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLK 630
+T + + R E+ LE + +L Q L A ++ V++ A +EK L+
Sbjct: 1374 QWRTKYETDA-----IQRTEE--LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426
Query: 631 EICDHQAEQLSRTS---LKLQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLHNN 683
+ + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486
Query: 684 QLISELESSVIKLE---EQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKC 740
++ + E S+ +LE + +L++++ LT+Q+ E + +L+ K
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQEKS 1542
Query: 741 EAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
E Q L + L EE K R+Q EL V+
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVK 1573
Score = 63.5 bits (153), Expect = 1e-09
Identities = 80/324 (24%), Positives = 134/324 (41%), Gaps = 52/324 (16%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE EK E E K LEE VTL E L
Sbjct: 844 LKSAETEKEMA-----NMKEEFEKTKE----ELAKTEAKRKELEEKMVTL---MQEKNDL 891
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E +A + +++ E E +E + A+K LE C
Sbjct: 892 QLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 952 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1001 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVT 778
R+ + DL+ A DI+ + QQ + KL ++E + + LQ ++ D Q G +
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQ----LDEKLKKKEFEMSGLQSKIEDEQALGMQLQ 1109
Query: 779 S--RAAPPPVDEEPESSEVDAAGR 800
+ ++E E E + A R
Sbjct: 1110 KKIKELQARIEELEEEIEAERASR 1133
Score = 54.7 bits (130), Expect = 5e-07
Identities = 112/511 (21%), Positives = 198/511 (38%), Gaps = 97/511 (18%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
KQ N A + + E AE +A E L +EL K K +A ++D
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIK----------NAYEESLD- 1497
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEE---------------NRVLKEKLIYLEH 259
+ L+ +NKN Q+E+SDL E+ +V +EK
Sbjct: 1498 ----------QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547
Query: 260 SPNSEGAASHTGDS--SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGS--- 314
+E + H + Q S + +ID+ K+N H + + S
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRN-HIRIVESMQSTLD 1606
Query: 315 ----SSSDVT--KASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSEL 368
S +D K + D ++ E I +R + +++++ + + L
Sbjct: 1607 AEIRSRNDAIRLKKKMEGDLNEME-IQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 369 -SLASLTEKIQKMEENHH---STAEELQATL-----------QELSDQQQMVQELTAENE 413
S L E++ +E + + EEL+ATL QEL D + VQ L +N
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1725
Query: 414 KLVDEKTILETSFHQHRERAEQLSQE----NEKLMN------LLQERVKNEEPTTQEGKI 463
L++ K LET Q + E + QE EK ++ E +K E+ T+ +
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 464 IELEQKCTGILEQGRFEREKLLNIQ------QQLTCSLR----KVEEENQGALEMIKRLK 513
++ + T Q R + + L ++ Q+L +R +VE E + +E +K L+
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLR 1845
Query: 514 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 573
+ K+ E + EE R + L+ L++ ++ K++A EA
Sbjct: 1846 KHERKVKE-----------LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1894
Query: 574 T--AESCEVQEMLKVARAEKDLLELSCNELR 602
++ +Q L+ A D+ E N+LR
Sbjct: 1895 VNLSKFRRIQHELEEAEERADIAESQVNKLR 1925
Score = 47.8 bits (112), Expect = 6e-05
Identities = 114/607 (18%), Positives = 224/607 (36%), Gaps = 94/607 (15%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++++S S TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1362 QRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKT 1421
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E ++ E T+A +D + + ++ ++K + EL ++E+
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQ---RNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHG- 306
R L +L ++++ T + +E+ + ++ I E K IH
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLET--------LKRENKNLQQEISDLTEQIAEGGKRIHEL 1530
Query: 307 NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS 366
++ +A+L + EH E + N KS
Sbjct: 1531 EKIKKQVEQEKSELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------------ 1576
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELSDQQQMV 405
+ +A E+I +M+ NH E +Q+TL E+ Q
Sbjct: 1577 DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1636
Query: 406 QELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPT 457
+ AE + L D + L+ + + EQL+ E+ NLLQ ++ T
Sbjct: 1637 NRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV-ERRANLLQAEIEELRAT 1695
Query: 458 TQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKE 514
+E ++ I EQ ER +LL+ Q + +K E + I +++
Sbjct: 1696 ------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ISQIQG 1743
Query: 515 ENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQT 574
E E + ++ R+ K + + + E LK E + +HL E+ K V+
Sbjct: 1744 EME---DIIQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNLEQTVKDL 1797
Query: 575 AESCEVQEMLKVARAEKDL--LELSCNELRQE--------------LLKANGEIKHVSSL 618
+ E L + +K + LE EL E L K ++K ++
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ 1857
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAV 678
+ K+ L+++ D ++ + +E +S+ + + ELE+ E+
Sbjct: 1858 TEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917
Query: 679 KLHNNQL 685
+ N+L
Sbjct: 1918 ESQVNKL 1924
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 95.9 bits (237), Expect = 2e-19
Identities = 48/105 (45%), Positives = 68/105 (64%), Gaps = 2/105 (1%)
Query: 963 SKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRN 1022
S ++ALL WCQ KT GY ++++TNF+SSW DGLAF AL+H + P I + +L + N
Sbjct: 174 SAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHN 233
Query: 1023 LLLAFEAAE-SVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYF 1066
L AF AE +GI P L+ E ++T+ PD +S++ YV Y YF
Sbjct: 234 LEHAFNVAERQLGIIPLLD-PEDVFTENPDEKSIITYVVAFYHYF 277
Score = 31.2 bits (69), Expect = 5.5
Identities = 79/407 (19%), Positives = 165/407 (40%), Gaps = 73/407 (17%)
Query: 383 NHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEK----------------------- 419
N H+ + QA + EL+ + ++ + AE ++L+DEK
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
Query: 420 TILETSFHQHRERAEQLSQEN----EKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILE 475
T E + H R+ L + K ++ +++++++++P + + K + +
Sbjct: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVED 1426
Query: 476 QGRFEREKLLNIQQQLTCSLRK-------VEEENQGALEMIKRLKEENEKLNEFLELERH 528
Q +E+L + Q+ + +E+ LE + R K++ E L++ R
Sbjct: 1427 QVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISR- 1485
Query: 529 NNNMMAKTL-EECRVTLEGLKMENGSLKSHLQGEK--QKATEASAVEQTAESCEVQEMLK 585
++ +TL E R+ L ++ ++LQ + K + E + V+++L+
Sbjct: 1486 --DLEDETLWVEERLPL----AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
Query: 586 VARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV-EKDYSYLKEICD-HQAEQL--- 640
+ + E+ C +L + L H+ S ++ E L+ + D ++A+Q
Sbjct: 1540 RGQQLVEAAEIDCQDLEERL-------GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
Query: 641 ---SRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN---NQLISELE---- 690
+ + QE SD KD + I L+ + Q RAV+ + QL S +
Sbjct: 1593 ADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652
Query: 691 ------SSVIKLEEQKSDLERQLKTLTKQMKEETEE-WRRFQADLQT 730
+I+L+ Q LK + ++ K + E + FQ +T
Sbjct: 1653 AGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRET 1699
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 95.9 bits (237), Expect = 2e-19
Identities = 48/105 (45%), Positives = 68/105 (64%), Gaps = 2/105 (1%)
Query: 963 SKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRN 1022
S ++ALL WCQ KT GY ++++TNF+SSW DGLAF AL+H + P I + +L + N
Sbjct: 174 SAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHN 233
Query: 1023 LLLAFEAAE-SVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYF 1066
L AF AE +GI P L+ E ++T+ PD +S++ YV Y YF
Sbjct: 234 LEHAFNVAERQLGIIPLLD-PEDVFTENPDEKSIITYVVAFYHYF 277
Score = 31.2 bits (69), Expect = 5.5
Identities = 79/407 (19%), Positives = 165/407 (40%), Gaps = 73/407 (17%)
Query: 383 NHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEK----------------------- 419
N H+ + QA + EL+ + ++ + AE ++L+DEK
Sbjct: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
Query: 420 TILETSFHQHRERAEQLSQEN----EKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILE 475
T E + H R+ L + K ++ +++++++++P + + K + +
Sbjct: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVED 1426
Query: 476 QGRFEREKLLNIQQQLTCSLRK-------VEEENQGALEMIKRLKEENEKLNEFLELERH 528
Q +E+L + Q+ + +E+ LE + R K++ E L++ R
Sbjct: 1427 QVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISR- 1485
Query: 529 NNNMMAKTL-EECRVTLEGLKMENGSLKSHLQGEK--QKATEASAVEQTAESCEVQEMLK 585
++ +TL E R+ L ++ ++LQ + K + E + V+++L+
Sbjct: 1486 --DLEDETLWVEERLPL----AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
Query: 586 VARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV-EKDYSYLKEICD-HQAEQL--- 640
+ + E+ C +L + L H+ S ++ E L+ + D ++A+Q
Sbjct: 1540 RGQQLVEAAEIDCQDLEERL-------GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
Query: 641 ---SRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN---NQLISELE---- 690
+ + QE SD KD + I L+ + Q RAV+ + QL S +
Sbjct: 1593 ADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652
Query: 691 ------SSVIKLEEQKSDLERQLKTLTKQMKEETEE-WRRFQADLQT 730
+I+L+ Q LK + ++ K + E + FQ +T
Sbjct: 1653 AGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRET 1699
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 94.7 bits (234), Expect = 4e-19
Identities = 189/847 (22%), Positives = 337/847 (39%), Gaps = 106/847 (12%)
Query: 33 KSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRS 92
K+ K L E L LK EDTL+ STA +R K+ + + + RS
Sbjct: 1143 KAEKQKRDLGEE--LEALK-TELEDTLD---STATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 93 GTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPST 152
++ A E + + + + R +N K+ + N + LR
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFK---RAKANLDKNKQTLEKENADLAGE-LRVLG- 1251
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
+ KQE E +K LE+QV+EL ++K D E R R+EL K E +
Sbjct: 1252 QAKQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 213 DGTSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHS 260
+G ++ DT+ +++ + N +L LEEE L+++L +E
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS--- 317
N E S T + S + F S T + ++K I + +++
Sbjct: 1367 QNLERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 318 -DVTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLAS 372
+ TK L + D + R L S F S E A
Sbjct: 1425 LEKTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1483 A--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------E 482
L + E++ L+E +++E T++ K+ LE + +G+FER E
Sbjct: 1541 KRALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEE 1596
Query: 483 KLLNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
K +Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAI 1651
Query: 542 VTLEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKD 592
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 593 LLELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------ 635
+L EL +EL L ++ ++ L ++E++ ++ + D
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVI 694
QAEQLS + A ++++ + ++ EL ++ E AVK I+ LE+ +
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKR 751
+LEEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 752 KLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSP 811
+L E EE++ R+ R +DE ES+E A GR S+
Sbjct: 1892 QLEEAEEESQRIN------------ANRRKLQRELDEATESNE--AMGREVNALKSKLRG 1937
Query: 812 TPPESAT 818
PP+ +
Sbjct: 1938 PPPQETS 1944
Score = 85.1 bits (209), Expect = 3e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 425
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 878 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 937
Query: 426 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 473
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 474 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 998 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1055
Query: 533 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 574
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1115
Query: 575 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 618
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 674
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1176 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 729
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1222 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
Query: 730 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Score = 82.0 bits (201), Expect = 3e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 902
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 903 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 953 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 1000
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 615
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 616 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 675 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1168
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1169 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1200
Score = 78.6 bits (192), Expect = 3e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 218
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1036
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 276
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1037 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1082
Query: 277 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 334
I + + ++ + + I NAL+ ++ D+
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1142
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 378
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 379 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1258
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 489
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 546
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1319 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1368
Query: 547 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 597
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 650
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 707
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 708 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 763
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1549 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 764 QKEL 767
+++L
Sbjct: 1598 RRQL 1601
Score = 65.9 bits (159), Expect = 2e-10
Identities = 131/681 (19%), Positives = 278/681 (40%), Gaps = 97/681 (14%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
++E + L+++ +++E + + + + R EL+K K K L + +D D
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIAD- 1080
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEE----NRVLKE------KLIYLEHSPNSE 264
+ L +K + Q L+ L++E N LK+ + L+ +SE
Sbjct: 1081 ---LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASL 324
AA + + Q+ G + D LR V K +L
Sbjct: 1138 RAARNKAEK-------QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 325 SPDASDFEHITAETPSR------PLSSTSNPFKSSKCSTAGSSPNSVSE-LSLASLTEKI 377
+ E E + L+ FK +K + + E LA +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 378 QKMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERA 433
+ ++ ++L+A +QEL SD ++ EL + KL +E + ++ +A
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 434 EQLSQENEKLMNLLQERVKNEEPTTQEG-----KIIELEQKCTGILEQGRFEREKLLNIQ 488
+L+++ L + LQ+ + + T++ K+ +LE++ + +Q E E N++
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 489 Q-------QLTCSLRKVEE---ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLE 538
+ QL+ S +K+++ + E KR ++E E L + E + + + KT
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 539 ECRVTLEGLKME---NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE 595
+ L+ L ++ L S+L+ +++K + A E+ S E +D E
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE--------RDRAE 1482
Query: 596 ----------LSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSL 645
LS +E L+A E++ + +L +D K+ +L ++
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 646 KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH--------NNQLISELESSVIKLE 697
L + ++++MK + ELED+++ KL Q +L++ + E
Sbjct: 1543 AL-------ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 698 EQKSDLERQLKTLTKQMKEETEE-------WRRFQADLQTAVVVANDI---KCEAQQELR 747
E++ L+RQL ++++E ++ ++ + DL+ + A+ + EA ++LR
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 748 TVKRKL--LEEEEKNARLQKE 766
++ ++ + E ++AR ++
Sbjct: 1656 KLQAQMKDFQRELEDARASRD 1676
Score = 65.1 bits (157), Expect = 3e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 551
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 984
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 671
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 985 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1028
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1084
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 94.7 bits (234), Expect = 4e-19
Identities = 189/847 (22%), Positives = 337/847 (39%), Gaps = 106/847 (12%)
Query: 33 KSSKSSTSLAFESRLSRLKRASSEDTLNKPGSTAASGVVRLKKTATAGAISELTESRLRS 92
K+ K L E L LK EDTL+ STA +R K+ + + + RS
Sbjct: 1136 KAEKQKRDLGEE--LEALK-TELEDTLD---STATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 93 GTGAFTTTKRTGIPAPREFSVTVSRERSVPRGPSNPRKSVSSPTSSNTPTPTKHLRTPST 152
++ A E + + + + R +N K+ + N + LR
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFK---RAKANLDKNKQTLEKENADLAGE-LRVLG- 1244
Query: 153 KPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNV 212
+ KQE E +K LE+QV+EL ++K D E R R+EL K E +
Sbjct: 1245 QAKQEVEH-KKKKLEAQVQEL--QSKCSDGE--RARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 213 DGTSVSPG-----------DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIY-LEHS 260
+G ++ DT+ +++ + N +L LEEE L+++L +E
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 261 PNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSS--- 317
N E S T + S + F S T + ++K I + +++
Sbjct: 1360 QNLERHIS-TLNIQLSDSKKKLQDFAS-TVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 318 -DVTKASLSPDASDFEHITAETPSRPLSST----SNPFKSSKCSTAGSSPNSVSELSLAS 372
+ TK L + D + R L S F S E A
Sbjct: 1418 LEKTKNRLQQELDDL--VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 373 LTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ ++ E S A L+ L+ + ++ + L AE E LV K + + H+ +
Sbjct: 1476 A--EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFER----------E 482
L + E++ L+E +++E T++ K+ LE + +G+FER E
Sbjct: 1534 KRALETQMEEMKTQLEE-LEDELQATEDAKL-RLEVNMQAL--KGQFERDLQARDEQNEE 1589
Query: 483 KLLNIQQQLTCSLRKVEEEN-QGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECR 541
K +Q+QL ++E+E Q AL + K E + + LEL+ + K EE
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD--LELQADS---AIKGREEAI 1644
Query: 542 VTLEGLKMENGSLKSHLQGEKQ---------KATEASAVEQTAESCEVQEMLKVARAEKD 592
L L+ + + L+ + K E A A+ ++QE L A +
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 593 LLELSCNELRQEL---LKANGEIK--------HVSSLLAKVEKDYSYLKEICDH------ 635
+L EL +EL L ++ ++ L ++E++ ++ + D
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 636 QAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQV-EQHRAVKLHNNQLISELESSVI 694
QAEQLS + A ++++ + ++ EL ++ E AVK I+ LE+ +
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 695 KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQ---ELRTVKR 751
+LEEQ R+ + TK +K++ ++ + ++ +A K +A++ ++ +KR
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 752 KLLEEEEKNARLQKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSP 811
+L E EE++ R+ R +DE ES+E A GR S+
Sbjct: 1885 QLEEAEEESQRIN------------ANRRKLQRELDEATESNE--AMGREVNALKSKLRG 1930
Query: 812 TPPESAT 818
PP+ +
Sbjct: 1931 PPPQETS 1937
Score = 85.1 bits (209), Expect = 3e-16
Identities = 102/466 (21%), Positives = 201/466 (43%), Gaps = 84/466 (18%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETS 425
+E L L +K ++ E + E+LQA + ++ ++M L A+ ++L + +E
Sbjct: 871 AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEAR 930
Query: 426 FHQHRERAEQLSQENEKL---MNLLQERVKNE---------EPTTQEGKIIELEQKCTGI 473
+ +R +QL E +K+ M L+E+++ E E T E KI +LE + +
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 474 LEQ-GRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNM 532
+Q + +E+ L ++++++ + EE + A + K LK ++E + LE+
Sbjct: 991 DDQNNKLSKERKL-LEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEK 1048
Query: 533 MAKTLEECRVTLEG------------------LKMENGSLKSHLQGEKQKATEASAVEQT 574
+ LE+ + LEG LKM+ + LQ + + A +
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 575 A---------ESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV-------SSL 618
A ++QE L RA ++ E +L +EL E++ L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 619 LAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMK----ETIFELEDQVEQ 674
AK E++ + LK+ D E+ +A++++M+ + + EL +Q+EQ
Sbjct: 1169 RAKREQEVTVLKKALD--------------EETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 675 HRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQ----- 729
+ K + L+ + LE++ +DL +L+ L + +E + ++ +A +Q
Sbjct: 1215 FKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Query: 730 -----TAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
A ND + Q E+ +V L E E K +L K++ +
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Score = 82.0 bits (201), Expect = 3e-15
Identities = 91/393 (23%), Positives = 180/393 (45%), Gaps = 49/393 (12%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
++ + EE + +ELQ T + + ++EL ++ +L +EK +L+ EQ
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQ----------EQ 895
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L E E + RV ++ +Q+ IL + E+ + QQL
Sbjct: 896 LQAETELYAEAEEMRV----------RLAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
+K+ ++ L++ ++L+EE E + L+LE+ K LE+ E L M++ +
Sbjct: 946 KKMAQQ---MLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLED-----EILVMDD---Q 993
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHV 615
++ +++K E + T E +E K K+ E +EL L K + +
Sbjct: 994 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 616 SSLLAKVEKDYS-YLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
L K+E D S + ++I D QA Q++ ++L +K E A + + + I + + +++
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQA-QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 675 HRAVKLHNNQLISELESSVI---KLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
R ++ H + L +L+S K E+QK DL +L+ L +++ D +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-----------DTLDS 1161
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+++ + +QE+ TV +K L+EE ++ Q
Sbjct: 1162 TATQQELRAKREQEV-TVLKKALDEETRSHEAQ 1193
Score = 78.6 bits (192), Expect = 3e-14
Identities = 141/664 (21%), Positives = 259/664 (39%), Gaps = 99/664 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEK---RTLNAEGTDALGPNVDGTSVS 218
EK E+++++L E D + N+L E K +E+ T N + N+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK-- 1029
Query: 219 PGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAAS--HTGDSSCP 276
E MI LE + K +K +LE+ LK KL EG AS H +
Sbjct: 1030 -NKHESMISELEVRLKKEEKSRQELEK----LKRKL---------EGDASDFHEQIADLQ 1075
Query: 277 TSITQESSFGSPTGNQMSSDIDEYKKNI--HGNALRTSGSSSSDVTKASLSPDASDFEHI 334
I + + ++ + + I NAL+ ++ D+
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN 1135
Query: 335 TAETPSRPLSSTSNPFKSSKCSTAGSSPNS----------VSELSLA------SLTEKIQ 378
AE R L K+ T S+ V+ L A S ++Q
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 379 KMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
+M + H EEL L++ ++ + Q L EN L E +L Q ++ E
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG----QAKQEVE 1251
Query: 435 QLSQENEKLMNLLQERVKNEEPTTQE--GKIIELE---QKCTGILEQGRFEREKLLNIQQ 489
++ E + LQ + + E E K+ +L+ + TG+L + + KL
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLN---EFLELERHNNNMMAKTLEECRVTLEG 546
L+ L+ +E Q +E +KLN + +LE N++ + EE +
Sbjct: 1312 SLSSQLQDTQELLQ---------EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK-QN 1361
Query: 547 LKMENGSLKSHLQGEKQKATE-ASAVEQTAESCE--------VQEMLKVARAEKDLLELS 597
L+ +L L K+K + AS VE E + + + + A D LE +
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYL-------KEICDHQAEQLSRTSLKLQEK 650
N L+QEL ++ + L++ +EK K I A++ R + +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLIS---ELESSVIKLEEQKSDLERQL 707
+++ + + ++E + E+ ++ +K L+S ++ +V +LE+ K LE Q+
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 708 KTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVK----RKLLEEEEKNARL 763
+ + Q++E L+ + D K + ++ +K R L +E+N
Sbjct: 1542 EEMKTQLEE-----------LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 764 QKEL 767
+++L
Sbjct: 1591 RRQL 1594
Score = 65.9 bits (159), Expect = 2e-10
Identities = 131/681 (19%), Positives = 278/681 (40%), Gaps = 97/681 (14%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
++E + L+++ +++E + + + + R EL+K K K L + +D D
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK--LEGDASDFHEQIAD- 1073
Query: 215 TSVSPGDTEPMIRALEEKNKNFQKELSDLEEE----NRVLKE------KLIYLEHSPNSE 264
+ L +K + Q L+ L++E N LK+ + L+ +SE
Sbjct: 1074 ---LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASL 324
AA + + Q+ G + D LR V K +L
Sbjct: 1131 RAARNKAEK-------QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 325 SPDASDFEHITAETPSR------PLSSTSNPFKSSKCSTAGSSPNSVSE-LSLASLTEKI 377
+ E E + L+ FK +K + + E LA +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 378 QKMEENHHSTAEELQATLQEL----SDQQQMVQELTAENEKLVDEKTILETSFHQHRERA 433
+ ++ ++L+A +QEL SD ++ EL + KL +E + ++ +A
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 434 EQLSQENEKLMNLLQERVKNEEPTTQEG-----KIIELEQKCTGILEQGRFEREKLLNIQ 488
+L+++ L + LQ+ + + T++ K+ +LE++ + +Q E E N++
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 489 Q-------QLTCSLRKVEE---ENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLE 538
+ QL+ S +K+++ + E KR ++E E L + E + + + KT
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 539 ECRVTLEGLKME---NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLE 595
+ L+ L ++ L S+L+ +++K + A E+ S E +D E
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE--------RDRAE 1475
Query: 596 ----------LSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSL 645
LS +E L+A E++ + +L +D K+ +L ++
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 646 KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLH--------NNQLISELESSVIKLE 697
L + ++++MK + ELED+++ KL Q +L++ + E
Sbjct: 1536 AL-------ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 698 EQKSDLERQLKTLTKQMKEETEE-------WRRFQADLQTAVVVANDI---KCEAQQELR 747
E++ L+RQL ++++E ++ ++ + DL+ + A+ + EA ++LR
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 748 TVKRKL--LEEEEKNARLQKE 766
++ ++ + E ++AR ++
Sbjct: 1649 KLQAQMKDFQRELEDARASRD 1669
Score = 65.1 bits (157), Expect = 3e-10
Identities = 62/282 (21%), Positives = 125/282 (44%), Gaps = 26/282 (9%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNE---FLELERHNNNMMAKTLEECRVTLEGLKMEN 551
L+K +E Q A +K L++++ +L E L+ + + EE RV L K E
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920
Query: 552 GSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGE 611
+ ++ ++ + Q Q+ML + E+ L E + +L K E
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL---EEQLEEEEAARQKLQLEKVTAE 977
Query: 612 IKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQ 671
K + K+E + + D Q +LS+ L+E+ I D+ + E E++
Sbjct: 978 AK-----IKKLEDEIL----VMDDQNNKLSKERKLLEER-------ISDLTTNLAEEEEK 1021
Query: 672 VEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTA 731
+ +K + +ISELE + K E+ + +LE+ L ++++ + ++ ADLQ
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEK----LKRKLEGDASDFHEQIADLQAQ 1077
Query: 732 VVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGH 773
+ + ++EL+ +L +E + K++ +++GH
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119
>gi|19913394 smoothelin isoform c [Homo sapiens]
Length = 917
Score = 94.4 bits (233), Expect = 5e-19
Identities = 45/105 (42%), Positives = 68/105 (64%), Gaps = 2/105 (1%)
Query: 963 SKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRN 1022
S + LL WC+ KT+GY ++DI NFSSSWSDG+AFCAL+H + P Y +L+ Q +++N
Sbjct: 800 SIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQN 859
Query: 1023 LLLAFEAAES-VGIKPSLELSEMLYT-DRPDWQSVMQYVAQIYKY 1065
+AF +AE V P +E+ +M+ +PD + V YV +Y +
Sbjct: 860 FEVAFSSAEMLVDCVPLVEVDDMMIMGKKPDPKCVFTYVQSLYNH 904
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 94.0 bits (232), Expect = 7e-19
Identities = 125/575 (21%), Positives = 244/575 (42%), Gaps = 93/575 (16%)
Query: 232 KNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN 291
K+ +KE++ ++E+ KE+L SE + S+ QE N
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELA------RSEARRKELEEKM--VSLLQEK-------N 889
Query: 292 QMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFK 351
+ + +N+ R G S + + + ++ E S ++ N
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRN--L 947
Query: 352 SSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAE 411
KCS S + +L L + K+E+ H+T +++ +E++ ++ + +LT E
Sbjct: 948 EDKCS---SLKRDIDDLELT-----LTKVEKEKHATENKVKNLSEEMTALEENISKLTKE 999
Query: 412 NEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCT 471
+ L + H++ + L E +K+ L++ K E+ T +E E+K
Sbjct: 1000 KKSLQEA----------HQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLR 1049
Query: 472 GILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNN 531
LE+ + + E L + Q+ S+ +E + Q E +K+ + E +L ++ E+ ++
Sbjct: 1050 ADLERAKRKLEGDLKMSQE---SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL 1106
Query: 532 MMAKTLEECRVTLEGLKME---NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVAR 588
K ++E + +E L+ E +L++ + EKQ++ A +E+ +E E A+
Sbjct: 1107 QFQKKIKELQARIEELEEEIEAEHTLRAKI--EKQRSDLARELEEISERLEEASGATSAQ 1164
Query: 589 AEKDLL-ELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKL 647
E + E ++R++L +A + + ++ L K + D + E+ + Q + L R KL
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS--VAELGE-QIDNLQRVKQKL 1221
Query: 648 QEKASESDAEIKDMKETIFEL--------------EDQVEQHRAVKLHNNQLISEL---- 689
+++ SE EI DM I L EDQ + +A QLI +L
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 690 -----------------ESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAV 732
ES + +L + K L +QL+ L +QM+EET+ LQ+
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS-- 1339
Query: 733 VVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 767
++ + ++ + EE+E A LQ+ L
Sbjct: 1340 ---------SRHDCDLLREQYEEEQEAKAELQRAL 1365
Score = 82.8 bits (203), Expect = 2e-15
Identities = 141/698 (20%), Positives = 274/698 (39%), Gaps = 103/698 (14%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKE--KRTLN------------------ 201
EK A E++V+ L E A + I++L E K +E ++TL+
Sbjct: 971 EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 202 -AEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEK------- 253
+ TD L +++ D E R LE K Q+ + DLE + + ++EK
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 254 LIYLEHSPNSEGAAS----------HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKN 303
L L+ + E S I E + + Q SD+ +
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ-RSDLARELEE 1149
Query: 304 IHGNALRTSGSSSSDV-----TKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTA 358
I SG++S+ + +A D E T + ++T ++ +
Sbjct: 1150 ISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ--HEATAATLRKKQADSVAEL 1207
Query: 359 GSSPNSV-----------SEL-----SLASLTEKIQKMEENHHSTAEELQATLQEL---- 398
G +++ SEL +AS E + K + N T ++ E+
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 399 SDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE-RVKNEEPT 457
Q Q++ +L + +L + L + QL++ + L L+E + + EE T
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEET 1327
Query: 458 TQEGKIIELEQK----CTGILEQGRFEREKLLNIQQQLTCSLRKVEE----ENQGALEMI 509
+ + Q C + EQ E+E +Q+ L+ + +V + A++
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 510 KRLKEENEKLNEFLELERHNN---NMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKAT 566
+ L+E +KL + L+ N N +LE+ + L+ G ++ ++ ++ T
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQ------GEVEDLMRDLERSHT 1441
Query: 567 EASAVEQTAES-----CEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAK 621
+ +++ + E ++ L ++AE + + L EL K + V L
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 622 VEKDYSYLKEICDHQAEQLSRTSLKLQEKASES---DAEIKDMKETIFELEDQVEQHRA- 677
+ ++ L+E EQ++ T LQE + E D++ + E+E +E +
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 678 ---VKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVV 734
V+L +Q+ SEL+ VI+ +E+ L+R + + ++ + R + D
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND------- 1614
Query: 735 ANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
A +K + + +L ++ +L + A QK L VQG
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Score = 70.5 bits (171), Expect = 8e-12
Identities = 147/676 (21%), Positives = 274/676 (40%), Gaps = 85/676 (12%)
Query: 163 KAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDT 222
K LE++V+EL E ++ E+N SEL +KR L + +L ++D ++
Sbjct: 916 KILLEAKVKEL-TERLEEEEEMN---SEL--VAKKRNLE-DKCSSLKRDIDDLELTLTKV 968
Query: 223 EPMIRALEEKNKNFQKELSDLEEE-NRVLKEKLIYLE-HSPNSEGAASHTGDSSCPTSI- 279
E A E K KN +E++ LEE +++ KEK E H + + I
Sbjct: 969 EKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKIN 1028
Query: 280 ------TQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDV------TKASLSPD 327
T + ++ +D++ K+ + G+ L+ S S D+ + L
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD-LKMSQESIMDLENDKQQIEEKLKKK 1087
Query: 328 ASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHST 387
+ + A+ + S K + E +L KI+K +
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARE 1146
Query: 388 AEELQATLQELSD----QQQMVQELTAENEKL---VDEKTILE--TSFHQHRERAEQLSQ 438
EE+ L+E S Q +M ++ AE +K+ ++E T+ T+ +++A+ +++
Sbjct: 1147 LEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE 1206
Query: 439 ENEKLMNLLQERVKNEEPTTQEGKIIE---------------LEQKCTGILEQGRFEREK 483
E++ NL + + K E+ ++ I+ +E+ C + +Q F K
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQ--FSEIK 1264
Query: 484 LLNIQQ-QLTCSL---------------RKVEEENQGALEMIK---RLKEENEKLNEFLE 524
+ QQ QL L +VEE+ ++ K L ++ E+L +E
Sbjct: 1265 AKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME 1324
Query: 525 LERHNNNMMAKTLEECRVTLEGLK---MENGSLKSHLQGEKQKATEASAVEQTAESCEVQ 581
E N MA L+ R + L+ E K+ LQ KA A +T +
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA- 1383
Query: 582 EMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS 641
+ R E+ LE + +L Q L +A + +S A +EK L+ + L
Sbjct: 1384 ----IQRTEE--LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 642 RT---SLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEE 698
R+ L +K D + + K+ + E + ++E + + + ++ ++ ++ +
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 699 QKSDLERQLKTLTKQMKEETEEWRRFQADLQTA---VVVANDIKCEAQQELRTVKRKLLE 755
Q L R+ K L +++ + TE+ +LQ A + K + Q L V+ L
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 756 EEEKNARLQKELGDVQ 771
EE K R+Q EL V+
Sbjct: 1558 EESKILRVQLELSQVK 1573
Score = 68.9 bits (167), Expect = 2e-11
Identities = 93/408 (22%), Positives = 165/408 (40%), Gaps = 83/408 (20%)
Query: 375 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
E++ + E E++ + LQE +D Q VQ +E E L+D + ER E
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQ---SETENLMDAE-----------ERCE 910
Query: 435 QLSQEN---EKLMNLLQERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQQ 489
L + E + L ER++ EE E K LE KC+ +
Sbjct: 911 GLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD-----------ID 959
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC-RVTLEGLK 548
L +L KVE+E +K L EE L E + K+L+E + TL+ L+
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK----KSLQEAHQQTLDDLQ 1015
Query: 549 ME----NGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQE 604
+E NG +K + + E+Q ++EQ K RA+ L +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQE----------KKLRAD----------LERA 1055
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASES---DAEIKDM 661
K G++K + +E D ++E + +LS+ K+ ++ S +IK++
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 662 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEW 721
+ I ELE+++E ++ K+E+Q+S L ++++E +E
Sbjct: 1116 QARIEELEEEIEAEHTLRA--------------KIEKQRS-------DLARELEEISERL 1154
Query: 722 RRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGD 769
+ + + E Q+ R ++ L+ E A L+K+ D
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202
Score = 66.2 bits (160), Expect = 2e-10
Identities = 145/717 (20%), Positives = 274/717 (38%), Gaps = 141/717 (19%)
Query: 145 KHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEG 204
K + K ++E + +++EL A + + EI + K +++R+ A
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146
Query: 205 TDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSE 264
+ + ++ S G T I +++ FQK DLEE L+H +
Sbjct: 1147 LEEISERLEEAS---GATSAQIEMNKKREAEFQKMRRDLEEAT---------LQHEATAA 1194
Query: 265 GAASHTGDSSCPTS------------ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRT- 311
DS + +E S + M+S+I+ K+ N RT
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS-KSNIERTC 1253
Query: 312 -------SGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNS 364
S + D + L D + + +T + LS K S S S +
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLN-MQKARLQTQNGELSHRVEE-KESLISQLTKSKQA 1311
Query: 365 VSELSLASLTEKIQKMEENHHSTAEELQATLQE---LSDQQQMVQELTAE--------NE 413
+++ L L ++++ + ++ A LQ++ + L +Q + QE AE N
Sbjct: 1312 LTQ-QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 414 KLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGI 473
++ +T ET Q R E+L + +KL LQE +N E T K LE+ +
Sbjct: 1371 EVAQWRTKYETDAIQ---RTEELEEAKKKLAQRLQEAEENTE--TANSKCASLEKTKQRL 1425
Query: 474 LEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMM 533
QG E E L+ ++ + ++++ + +++ K++ ++ LE + + +
Sbjct: 1426 --QG--EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSL 1481
Query: 534 AKTL-------EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKV 586
+ L EE LE L+ EN +L+ + + T + E + L+
Sbjct: 1482 STELFKMRNAYEEVVDQLETLRRENKNLQEEIS------------DLTEQIAETGKNLQE 1529
Query: 587 ARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQA-------EQ 639
A K L+E ++L+ L + G ++H S + +V+ + S +K D + EQ
Sbjct: 1530 AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ 1589
Query: 640 LSRTSLKLQEKA-SESDAEIK--------------DMKETIFEL---------------- 668
L R S + E S DAEI+ D+ E +L
Sbjct: 1590 LKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRT 1649
Query: 669 -------------------EDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKT 709
ED EQ V+ N L+ ELE + LE+ ER +
Sbjct: 1650 VQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ----TERTRRL 1705
Query: 710 LTKQMKEETEEWRRFQADLQTAV-----VVANDIKCEAQQELRTVKRKLLEEEEKNA 761
+++ + ++ + + + + + A+ +C+A+ E + + EE+ K A
Sbjct: 1706 SEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762
Score = 64.3 bits (155), Expect = 6e-10
Identities = 129/638 (20%), Positives = 249/638 (39%), Gaps = 76/638 (11%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSV- 217
LE R++ E KAK++ + L+S ++Y+E++ AE AL +
Sbjct: 1316 LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQW 1375
Query: 218 -SPGDTEPMIRA--LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNS----------E 264
+ +T+ + R LEE K + L + EE K LE + +
Sbjct: 1376 RTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 265 GAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASL 324
SHT +C T ++ +F + +DE + + A + S S S+++ K
Sbjct: 1436 LERSHT---ACATLDKKQRNFDKVLA-EWKQKLDESQAELEA-AQKESRSLSTELFKMRN 1490
Query: 325 SPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENH 384
+ + + T ++ L + T L A T+K+ + E++
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETG-------KNLQEAEKTKKLVEQEKSD 1543
Query: 385 HSTA-EELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 443
A EE++ +L+ + VQ ++ + +D K I + E EQL + +++
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI------EKDEEIEQLKRNSQRA 1597
Query: 444 MNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQ 503
LQ + E + + + L++K G L + + + LR V+ + +
Sbjct: 1598 AEALQSVLDAEIRSRNDA--LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 504 GALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQ 563
+ + NE L E L + N ++ + LEE +V LE + + L
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 564 KA-----------TEASAVEQTAESC--EVQEMLKVARAEKDLLELSCNE---LRQELLK 607
+ +E C EV+ ++ +R ++ + + + + +EL K
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775
Query: 608 ANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS---------RTSLKLQEKASESDAEI 658
H+ + +E+ L+ D +AEQL+ + +++E +E D E
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLENRVRELENELDVEQ 1834
Query: 659 KDMKETI-----FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ 713
K E + +E + + ++A + H N I L+ V KL+ + +RQ + +Q
Sbjct: 1835 KRGAEALKGAHKYERKVKEMTYQAEEDHKN--ILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Query: 714 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKR 751
+ RR Q +L+ A A DI +LR R
Sbjct: 1893 ANTQLSRCRRVQHELEEAAERA-DIAESQVNKLRAKSR 1929
Score = 53.1 bits (126), Expect = 1e-06
Identities = 109/573 (19%), Positives = 221/573 (38%), Gaps = 47/573 (8%)
Query: 176 EAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVS-PGDTEPMIRALE---- 230
+A + E+ + +L + ++ N E ++ +++ T G+ E ++R LE
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 231 ------EKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESS 284
+K +NF K L++ +++ + +L + S ++ + Q +
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 285 FGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLS 344
N + +I + + I A ++ TK + + SD + E S
Sbjct: 1502 LRRENKN-LQEEISDLTEQI---AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEG---S 1554
Query: 345 STSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQM 404
K + S S + + E+I++++ N AE LQ+ L +
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 405 VQELTAENEKLVDEKTILETSFHQHRERAE----------QLSQENEKLMNLLQERVKNE 454
L + E ++E I H +R+ AE QL L + L+ +
Sbjct: 1615 ALRLKKKMEGDLNEMEI--QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK 1672
Query: 455 EPTT----QEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS--LRKVEEENQGALEM 508
E + G ++E ++ LEQ ER + L+ Q+ L S ++ + +N +
Sbjct: 1673 EQLAIVERRNGLLLEELEEMKVALEQT--ERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 509 IKRLKEE----NEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQK 564
K+L+ + ++ ++ R+ K + + + E LK E + +HL E+ K
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMK 1787
Query: 565 ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEK 624
V+ + E L + +K + +L N +R+ + + E K + L K
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE-NRVRELENELDVEQKRGAEALKGAHK 1846
Query: 625 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 684
+KE+ +QAE+ + L+LQ+ + A++K K E E+Q +
Sbjct: 1847 YERKVKEMT-YQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 685 LISELESSVIKLEEQKSDLERQLKTLTKQMKEE 717
+ E E Q + L + + + Q EE
Sbjct: 1906 ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 94.0 bits (232), Expect = 7e-19
Identities = 139/645 (21%), Positives = 271/645 (42%), Gaps = 68/645 (10%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRT-LNAEGTDALGPNVDGTSVSPG 220
E L+ +++EL K +++I +S+L+ K+ + L E A TS+ G
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 221 DTEPMIRA---LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPT 277
+ LE K + QKEL+ EEN L+E++I L +
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 278 SITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAE 337
S +E + +++ S++ + + G L G + D+ + ++D E +
Sbjct: 767 S--EELHIITSEKDKLFSEVVHKESRVQG-LLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 338 TPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQE 397
T N + +L+++ QK + + + EL QE
Sbjct: 824 TLHMDFEQKYKMVLEE---------NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 398 LSDQQQMVQELTAENEKLVDE----KTILETSFHQHRERAEQLSQENEKLMNLLQERVKN 453
L ++ + VQE E E+L ++ + L+T + E+L Q E++ L QE K+
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE--KD 932
Query: 454 EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+ QE IE +Q + I + ++ Q+QL +L +++ E I LK
Sbjct: 933 DLKQLQESLQIERDQLKSDIHDTVNMN----IDTQEQLRNALESLKQHQ----ETINTLK 984
Query: 514 EENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQ 573
K++E + H +T +E + + G+ + + Q + +EQ
Sbjct: 985 ---SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041
Query: 574 -------TAESCEVQEMLKVARAEKDLLELSCN-------ELRQELLKANGEIKHVSSLL 619
E E+Q+ML+ AEK+ L+ E ++EL E+K ++
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 620 AKVEKDYSYLKE-----ICDHQA---EQLSRTSLKLQEKASE---SDAEIKDMKETIFEL 668
A+ EK+++ KE CD A E+L S +LQEK + E+ +M++ I E+
Sbjct: 1102 AQ-EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 669 EDQVEQHRAVKLHNNQL-ISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQAD 727
E+ + L N +L + +E+ ++L ++ ++ ++K++TK+ K E + F+ +
Sbjct: 1161 ENLKNE-----LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215
Query: 728 LQTAVVVANDIKC---EAQQELRTVKRKLLEEEEKNARLQKELGD 769
+I+ + ++EL+ L E +E L++ + +
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Score = 80.1 bits (196), Expect = 1e-14
Identities = 89/413 (21%), Positives = 184/413 (44%), Gaps = 40/413 (9%)
Query: 375 EKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENE--KLVDEKTILETSFHQHRER 432
E +Q + +E+ A ++E +++ ++TA NE + + E L+ F +
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLL-NIQQQL 491
E + EN +L +L E ++ T+E + E + ER++L N+++ +
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKE------RDDLRSVEETLKVERDQLKENLRETI 1713
Query: 492 TCSLRKVEE---------ENQGALEMIKRLKEE--NEKLNEFLELERHNNNMMAKTL--- 537
T L K EE E+Q ++ ++ + E NE N +LE N+ + A+ L
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 538 EECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELS 597
EE R+ LK + ++ +K + S +++ E+ A+ ++ + EL
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSN-------AKLQEKIQELK 1826
Query: 598 CNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAE 657
NE + LK K V+ KV + K+I D Q+ LS+ ++ A +
Sbjct: 1827 ANEHQLITLK-----KDVNETQKKVSEMEQLKKQIKD-QSLTLSKLEIENLNLAQKLHEN 1880
Query: 658 IKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEE 717
+++MK + E ++ +KL +QL L+ + + + +++++LKT KE
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQET----KARDLEIQQELKTARMLSKEH 1936
Query: 718 TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDV 770
E + + + + +DI+ + + +++K+ E ++K +L + DV
Sbjct: 1937 KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Score = 78.6 bits (192), Expect = 3e-14
Identities = 118/647 (18%), Positives = 264/647 (40%), Gaps = 48/647 (7%)
Query: 147 LRTPSTKPKQENEG--------GEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
L+ K +ENE E +L S+V L E + K E++ + SE K +
Sbjct: 725 LQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV 784
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + T T+ ++ +++ +NF+ D E++ +++ E+ +
Sbjct: 785 VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ + DSS ++ E S+ + + + ++ E + +
Sbjct: 845 QEIVNLSKEAQKFDSSL-GALKTELSYKTQELQEKTREVQERLNEM-------------E 890
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
K L S + + E + L + + T + + +L + E+ Q
Sbjct: 891 QLKEQLENRDSTLQTVERE---KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947
Query: 379 KMEENHHS------TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRER 432
+ H + T E+L+ L+ L Q+ + L ++ + V +E + + ++
Sbjct: 948 LKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 433 AEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI---QQ 489
+Q +K +L + + ++ +IIE ++K ++++ ++ L ++ ++
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHN----NNMMAKTLEECRVTLE 545
QL L++ E E ++ L +E +K E + E+++ +++T + E
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 546 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCE-VQEMLKVARAEKDLLELSCNELRQE 604
LK ++ L+ Q E S +++ E ++ LK + +E EL Q+
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 605 LLKANGEIKHVS---SLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDM 661
L + E+K ++ +L +++K + ++ ++ T L+ +E+ + +K+
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH 1247
Query: 662 KETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL--ERQLKTLTKQMKEETE 719
+ETI EL V + + ++ N Q +LE S KL+E+ L E++L K++ E E
Sbjct: 1248 QETIDELRRSVSE-KTAQIINTQ---DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303
Query: 720 EWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
+ + + + + E + K E +E+ L KE
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Score = 76.3 bits (186), Expect = 1e-13
Identities = 92/428 (21%), Positives = 201/428 (46%), Gaps = 36/428 (8%)
Query: 370 LASLTEKIQKMEE-NHHSTAEE--LQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
++ + EK+ ++++ H A++ LQ+ ++ + +QE E + ++ EK ++
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILE-QGRFEREKLL 485
+ +QL + ++++ ++E + E + + E ++K I + +FE +K L
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQK-L 1658
Query: 486 NIQQQLTCSLR--KVEEENQGALEMIKRLKEENEKLNEFLELERHN-NNMMAKTLEECRV 542
N++ T ++R ++ EN + + + +++ + E L++ER + +T+
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 543 TLEGLKMENGSLKSHLQ----------------GEKQKATEASAVEQTAESCEVQEMLKV 586
E LK+ + LK H + QK E S A+ ++QE L++
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
Query: 587 ARAEKDLLELSCNELR----QELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSR 642
A + + ++LR ++ K + K + + AK+++ LK +HQ L +
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK-ANEHQLITLKK 1837
Query: 643 TSLKLQEKASESD---AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQ 699
+ Q+K SE + +IKD T+ +LE + + A KLH N + E++ SV+K +
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE-NLNLAQKLHEN--LEEMK-SVMKERDN 1893
Query: 700 KSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEK 759
+E LK Q+KE +E + ++Q + A + E ++ + ++ K+ E+ +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 760 NARLQKEL 767
+ +QK+L
Sbjct: 1954 ISDIQKDL 1961
Score = 72.0 bits (175), Expect = 3e-12
Identities = 138/701 (19%), Positives = 283/701 (40%), Gaps = 119/701 (16%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK + ++++ L E K E + +LK+ +E + D L ++ T D
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQE----KDDLKQLQESLQIER---DQLKSDIHDTVNMNID 961
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
T+ +R E K Q+ ++ L+ + + E++ H + G I +
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSK---ISEEVSRNLHMEENTGETKDEFQQKM-VGIDK 1017
Query: 282 ESSFGSPTGNQMSSDID-----EYKKNIHG-----NALRTSGSSSSDVTKASLSPDASDF 331
+ + +++D+ E ++ I N L+ S K L D +
Sbjct: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM-LESVIAEKEQLKTDLKEN 1076
Query: 332 EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVS---ELS-----LASLTEKIQKMEEN 383
+T E L + K + A +++ ELS LA + EK+++ +
Sbjct: 1077 IEMTIENQEE-LRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 384 HHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 443
++L +E+S+ Q+ + E+ +L +++ LE + E A++L++ E++
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 444 MNLLQERVKNEE------------------------PTTQEGKI--IELEQKCTGILEQG 477
++ +ER +E T +E KI I L++ I E
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 478 RFEREKLLNI--QQQLTCSLRKVEE------ENQGALEMIKRLKEENEKLNEF------- 522
R EK I Q L S K++E E Q L +K + E E +NE
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 523 ----------LELERHNNN-----------MMAKTLEECRVTLEGLKMENGSLKSHLQGE 561
+E+ER N + K + + E L++++ LK H++
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 562 KQKATEASAVEQTAESCE---------VQEMLKVARAEKDLL--ELSCNELRQELLKANG 610
K E+ + ++ + + + V EM + + LL E+ L + L +++
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 611 EIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED 670
E+K V AK + D L+E+ +++QL ++ K E++ E+K + E E+
Sbjct: 1436 EMKSV----AKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Query: 671 QVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ-ADLQ 729
+ + R +SE E+ + +++Q + +L+ +++ E+ E++ Q +++Q
Sbjct: 1492 TINELRV-------NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 730 TAVVVANDIKCEAQQE---LRTVKRKLLEEEEKNARLQKEL 767
V K + + L++++ K+LE + Q+E+
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585
Score = 70.5 bits (171), Expect = 8e-12
Identities = 83/393 (21%), Positives = 176/393 (44%), Gaps = 53/393 (13%)
Query: 389 EELQATLQELSDQQQMVQ-ELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL 447
+EL T +++ + Q+ Q +L A+ + VD + L+++F+ E KL +L+
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFN-----------EITKLTSLI 704
Query: 448 QERVKNEEPTTQE--GKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGA 505
+V + E GKI +L+++ +E+ RE+++ L L+ + E
Sbjct: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVI-----LLSELKSLPSE---- 755
Query: 506 LEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA 565
++RL++E + +E L + + + + ++GL E G K L A
Sbjct: 756 ---VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL------A 806
Query: 566 TEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE-LRQELLKANGEIKHVSSLLAKVEK 624
T S + T + + + L + +K + L NE + QE++ + E + S L ++
Sbjct: 807 TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT 866
Query: 625 DYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQ 684
+ SY + +LQEK E + +M++ +LE++ + V+
Sbjct: 867 ELSYKTQ--------------ELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTL 912
Query: 685 LISELESS---VIKLEEQKSDLERQLKTLT---KQMKEETEEWRRFQADLQTAVVVANDI 738
+ +L+ + V L ++K DL++ ++L Q+K + + D Q + A +
Sbjct: 913 ITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES 972
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
+ Q+ + T+K K+ EE +N +++ G+ +
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Score = 67.8 bits (164), Expect = 5e-11
Identities = 90/431 (20%), Positives = 190/431 (44%), Gaps = 65/431 (15%)
Query: 386 STAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRE-RAEQLSQENEKLM 444
S E++ +E+ D+ + + +T+E +KL E H+E R + L +E K
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV--------HKESRVQGLLEEIGKTK 802
Query: 445 NLLQERVKNEEPTTQEGKI-----IELEQKCTGILEQGRFEREKLLNIQ---QQLTCSLR 496
+ L N + T QE + ++ EQK +LE+ ++++N+ Q+ SL
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862
Query: 497 KVEEE-NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
++ E + E+ ++ +E E+LNE +L+ LE TL+ ++ E +
Sbjct: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQ--------LENRDSTLQTVEREKTLIT 914
Query: 556 SHLQGEKQKATEASAVEQTAESC-EVQEMLKVARAE-----KDLLELSCN---ELRQELL 606
LQ Q E + Q + ++QE L++ R + D + ++ + +LR L
Sbjct: 915 EKLQ---QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 607 KANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIF 666
+ +++L +K+ ++ S + ++ E K+ + D E K+ +
Sbjct: 972 SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTA 1031
Query: 667 ELEDQ--VEQHRAVKL---HNNQLISELESSVIKLEEQKSDL----------ERQLKTLT 711
+++D +EQ R + N+L LES + + E+ K+DL + +L+ L
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG 1091
Query: 712 KQMKEETE-----------EWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKN 760
++K++ E + V +K E Q+L+ +++LL +E+
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLK-EKSQQLQEKQQQLLNVQEEM 1150
Query: 761 ARLQKELGDVQ 771
+ +QK++ +++
Sbjct: 1151 SEMQKKINEIE 1161
Score = 60.1 bits (144), Expect = 1e-08
Identities = 87/420 (20%), Positives = 187/420 (44%), Gaps = 42/420 (10%)
Query: 367 ELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSF 426
E S A L EKIQ+++ N H +L +++++ Q+ V E+ +++ D+ L
Sbjct: 1812 ENSNAKLQEKIQELKANEH----QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 427 HQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLN 486
++ A++L + E++ ++++ER + +E +E +Q + E + + + L
Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKER--DNLRRVEETLKLERDQ----LKESLQETKARDLE 1921
Query: 487 IQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEF-LELERHNNNMMAKTLEECRVTLE 545
IQQ+L + +E + ++ +++ E+ ++++ +L++ + + K E + L+
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 546 GLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEM-LKVARAEKDLLELSCNELRQE 604
L+++ SH + + +EQ + E Q + ++ R + L +E +E
Sbjct: 1982 LLRVKEDVNMSH--------KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 605 L---LKANGEIKHVSSLLAKVEKD--YSYLKEIC--DHQAEQ-------LSRTSLKLQEK 650
+ K E++ + L K+E+D + L+E+ D Q Q LS L E
Sbjct: 2034 IRIVAKERDELRRIKESL-KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTES 2092
Query: 651 ASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTL 710
E + IK++ + E++D E + L + I + ++++ S Q K +
Sbjct: 2093 LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHI 2152
Query: 711 TKQMKEE---TEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKEL 767
K + E+ R L+ + IK E + + + ++E EK QKEL
Sbjct: 2153 EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEK----QKEL 2208
Score = 54.3 bits (129), Expect = 6e-07
Identities = 95/452 (21%), Positives = 195/452 (43%), Gaps = 44/452 (9%)
Query: 353 SKCSTAGSSPNSVSELSLASLTEKIQKM-EENHHSTAEELQATLQEL--------SDQQQ 403
S CS + N++ LS + + +EN S L+A L +++++
Sbjct: 464 SVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEE 523
Query: 404 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE-RVKNEEPTTQEGK 462
M +L +N+ +DE LE + +E QL E L NL++ V N++ +
Sbjct: 524 MELKLKEKND--LDEFEALERKTKKDQEM--QLIHEISNLKNLVKHAEVYNQDLENELSS 579
Query: 463 IIELEQKCTGILE--QGRFEREKLLNIQQQLTCSLRKVEEENQGALEMI---------KR 511
+EL ++ ++ Q + +KL NI+ L+ SL +E+ Q + KR
Sbjct: 580 KVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKR 639
Query: 512 ----LKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATE 567
L+ EN +L E ++ M ++ + LE K L+ LQ + T+
Sbjct: 640 ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699
Query: 568 ASAVEQTAES----CEVQEMLKVARAEKDL-LELSCNE-LRQELLKANGEIKHVSSLLAK 621
+++ C ++ K+ +K+L E+ NE LR+E++ + + SL ++
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVIL----LSELKSLPSE 755
Query: 622 VEKDYSYLKEICDHQAEQLSRTSL--KLQEKASESDAEIKDMKETIFELEDQVEQHRAVK 679
VE+ KEI D E TS KL + ++ ++ + E I + +D + ++
Sbjct: 756 VER---LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 680 LHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIK 739
+Q ++ + E++ + + + + +++ ++E ++F + L +
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 740 CEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
E Q++ R V+ +L E E+ +L+ +Q
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Score = 46.2 bits (108), Expect = 2e-04
Identities = 74/364 (20%), Positives = 146/364 (40%), Gaps = 50/364 (13%)
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 436
+ K++E H + + + + E+ + E L+ + + + RE +
Sbjct: 2180 VTKIKEEQHESINKFE---------MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK 2230
Query: 437 SQENEKLM--NLLQERVKNEEPT--TQEGKIIELEQKCTGILEQG---RFEREKLLNIQQ 489
+N L +L++ ++E P+ T+ +++ ++ T LE+ RF+ EKL N Q
Sbjct: 2231 LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQ 2290
Query: 490 QLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKM 549
+ + +V + I +NE E E + A +E L+ LK
Sbjct: 2291 KENDRICQVNNFFNNRIIAI---------MNESTEFEERS----ATISKEWEQDLKSLKE 2337
Query: 550 ENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKAN 609
+N L + Q K + V T + + V L EL L +A
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQVNPTTQD---NKNPHVTSRATQLTTEKIRELENSLHEAK 2394
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELE 669
H S + K++K+ +I KLQ K ES+ ++ KETI L+
Sbjct: 2395 ESAMHKESKIIKMQKELEVTNDII-----------AKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 670 DQVEQHRAVKLHNNQLISELESSVIKLEEQK----SDLERQLKTLTKQMKEETEEWRRFQ 725
D+V K + + I +L+ ++K++ +K + E+++ ++ + E R +
Sbjct: 2444 DKVA--LGAKPYKEE-IEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 726 ADLQ 729
+L+
Sbjct: 2501 ENLR 2504
Score = 41.2 bits (95), Expect = 0.005
Identities = 82/418 (19%), Positives = 175/418 (41%), Gaps = 71/418 (16%)
Query: 366 SELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAEN---EKLVDEKTIL 422
S+ L +++QK E E++ + +++++ +Q+ ++ A+N + + + L
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL 2023
Query: 423 ETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFERE 482
H+ E +++E ++L R+K ++ I L + + + + E
Sbjct: 2024 TKKLHESLEEIRIVAKERDEL-----RRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 483 K--LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC 540
K L + QQ LT SLR E R+K E L + E++ H EC
Sbjct: 2079 KRLLSDGQQHLTESLR----------EKCSRIK---ELLKRYSEMDDH---------YEC 2116
Query: 541 RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
L L ++ L+ ++ +K+ + A + + + + K+ A + C+
Sbjct: 2117 ---LNRLSLD---LEKEIEFQKELSMRVKA-NLSLPYLQTKHIEKLFTANQ-----RCSM 2164
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDY-----SYLKEICDHQAEQLSRTSLKLQEKASESD 655
++K ++K+V S + K++++ + + D + E+ +K+Q + D
Sbjct: 2165 EFHRIMK---KLKYVLSYVTKIKEEQHESINKFEMDFID-EVEKQKELLIKIQHLQQDCD 2220
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
+++++ +L ++ H L + SE E IK E Q Q+ + K+M
Sbjct: 2221 VPSRELRD--LKLNQNMDLHIEEILKD---FSESEFPSIKTEFQ------QVLSNRKEMT 2269
Query: 716 EETEEWRRFQAD---LQTAVVVANDIKCEA----QQELRTVKRKLLEEEEKNARLQKE 766
+ EEW + D L+ + ND C+ + + + E EE++A + KE
Sbjct: 2270 QFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE 2327
Score = 36.2 bits (82), Expect = 0.17
Identities = 86/423 (20%), Positives = 157/423 (37%), Gaps = 71/423 (16%)
Query: 404 MVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKI 463
+ +E+ +E + T E S H + Q S + + ++ E + EP+ EG +
Sbjct: 167 LTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSV 226
Query: 464 IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL---EMIKRLKE------ 514
+ R + ++ + C++ N+ ++IK+L +
Sbjct: 227 KVSHLNLVDLAGSERAAQTGAAGVRLKEGCNI------NRSLFILGQVIKKLSDGQVGGF 280
Query: 515 ---ENEKLNEFLELERHNNNMMAKTLEECRVT---------------------------- 543
+ KL L+ N AKT C +T
Sbjct: 281 INYRDSKLTRILQNSLGGN---AKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNE 337
Query: 544 -------LEGLKMENGSLKSHLQGEKQKATEASAVE--QTAESCEVQEMLKVARAEK--- 591
L+ + E LK L+ E T A A+E Q A+ E +++L+ + EK
Sbjct: 338 VSTDEALLKRYRKEIMDLKKQLE-EVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 592 --DLLELSCNELRQELLKANGEIKHVSSLLAKVEK----DYSYLKEICDHQAEQLSRTSL 645
+L S + Q+ LKA + + V+ L K+ K +Y+ I + + + S+
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRK-RRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSI 455
Query: 646 KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI-SELESSVIKLEEQKSDLE 704
L + ES D+ + ++E + A KL N + I SEL S + D E
Sbjct: 456 NLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYE 515
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
QL+T ++M+ + +E D + + E+ +K + E N L+
Sbjct: 516 -QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLE 574
Query: 765 KEL 767
EL
Sbjct: 575 NEL 577
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 93.6 bits (231), Expect = 9e-19
Identities = 141/631 (22%), Positives = 258/631 (40%), Gaps = 103/631 (16%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN---------SEGA--ASH 269
+TE + ++E+ + + EL+ E + + L+EK++ L N +EG A
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 910 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 961
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 962 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1014
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1015 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
QE + + E Q +L++K L++ FE + N+Q K+E+E +
Sbjct: 1068 AQESIMDIENEKQ-----QLDEK----LKKKEFE---ISNLQS-------KIEDEQALGI 1108
Query: 507 EMIKRLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKS 556
++ K++KE E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSA 1165
Query: 557 HLQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQ 603
++ K++ E + + E +Q A K D L+ +L +
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
E + EI ++S + V K L+++C +QLS +L+ K E I D+
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTA 1281
Query: 664 TIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---------- 713
L+ + + L+S+L +Q +L+RQL+ K
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 714 -------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQK 765
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 766 ELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 796
L + H V ++ A ++ +EV+
Sbjct: 1402 RLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432
Score = 81.3 bits (199), Expect = 5e-15
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 81/633 (12%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ-------VDDLEGSLEQEKKLRMD 1053
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E R LE K Q+ + D+E E + L EKL E S+ + I
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI-----------SNLQSKIED 1102
Query: 282 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
E + G Q+ I E + I +S +A SD SR
Sbjct: 1103 EQALGI----QLQKKIKELQARIEELEEEIEAERAS---RAKAEKQRSDL--------SR 1147
Query: 342 PLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 399
L S + + +T+ N E + +++ H +TA L+ ++
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 400 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 456
+ + + L +KL EK+ ++ E +S+ EK+ L++++ +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 457 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+E + + + Q+ E G F R+ L+ ++ L L + ++ +E +KR
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQ--LDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 514 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA-TEA 568
EE K L L+ RH+ +++ + EE + + K+ LQ KA TE
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-----------KAELQRALSKANTEV 1374
Query: 569 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 628
+ E+ +Q ++ A+K +L Q L A ++ V++ A +EK
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 629 LKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLH 681
L+ + + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 682 NNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
++ + E S+ +LE K + L++++ LT+Q+ E + +L+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQE 1542
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
KCE Q L + L EE K R+Q EL V+
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVK 1575
Score = 76.3 bits (186), Expect = 1e-13
Identities = 133/640 (20%), Positives = 251/640 (39%), Gaps = 94/640 (14%)
Query: 145 KHLRTPSTKPKQENEGGEKAA------LESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
K LR + K++ EG K A +E++ ++L + K K+ EI+ L+S K ++++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS---KIEDEQ 1104
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1105 ALGIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1156
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ GA S + + +E+ F +M D++E A +
Sbjct: 1157 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
V A L + + + + S + LAS E +
Sbjct: 1206 V--AELGEQIDNLQRVKQKLEKE------------------KSEMKMEIDDLASNVETVS 1245
Query: 379 KMEENHHSTAEELQATLQELS----DQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
K + N L+ L EL +QQ+++ +LTA+ +L E +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 435 QLS-------QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI 487
QLS Q+ E+L L+E +K + + C + EQ E+E +
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA--LQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 488 QQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 547
Q+ L+ + +V + R K E + + ELE + A+ L+ +E +
Sbjct: 1364 QRALSKANTEVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQAAEEHVEAV 1413
Query: 548 KMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQE 604
+ SL+ Q + + + VE+T +C + K +K L E C E E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAE 1472
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 664
L + E + + + L K++ Y +E D Q E L R + LQ++ S+ +I + +
Sbjct: 1473 LEASQKEARSLGTELFKIKNAY---EESLD-QLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 665 IFELEDQVEQHRAVKLHNNQLISELESSV-----------IKLEEQKSDLERQLKTLTKQ 713
I ELE +Q K + E E+S+ ++L + KS+++R++ +
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI----AE 1584
Query: 714 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKL 753
EE ++ +R + ++ D + ++ + +K+K+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Score = 73.9 bits (180), Expect = 7e-13
Identities = 95/406 (23%), Positives = 175/406 (43%), Gaps = 60/406 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE Q EL+ + +EL + L+ EK L+ Q + AE
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAEG 903
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 904 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 946
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 947 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 609
LQ Q+ + E+ + + +K+ + DL LE +LR +L +A
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKLRMDLERAKRKL 1061
Query: 610 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 665
G++K + +E + L E + ++S K++++ + + +IK+++ I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 725
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1122 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1158
Query: 726 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Score = 63.2 bits (152), Expect = 1e-09
Identities = 80/332 (24%), Positives = 141/332 (42%), Gaps = 68/332 (20%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +K+ + E + K LEE VTL LK +N L
Sbjct: 846 LKSAETEKEMAT-----MKEEFQKIKD----ELAKSEAKRKELEEKMVTL--LKEKN-DL 893
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 954 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1003 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 768
R+ + DL+ A DI+ E QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 769 DVQGHGRVVTSRAAPPPVDEEPESSEVDAAGR 800
++Q ++E E E + A R
Sbjct: 1116 ELQAR------------IEELEEEIEAERASR 1135
Score = 58.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 235/634 (37%), Gaps = 111/634 (17%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++++S + TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E L+ E T+A AL++K +NF K L++ +++
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAA-----------------CAALDKKQRNFDKILAEWKQKC 1466
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN------QMSSDIDEYK 301
+L + S G ++ S+ Q + N ++ I E
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 302 KNIHG-NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
K IH ++ +A+L + EH E + N KS
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------ 1578
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELS 399
+ +A E+I +++ NH E +Q+TL E+
Sbjct: 1579 ------DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 400 DQQQMVQELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q + AE + L D + L+ + + EQL+ E+ NLLQ +
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEI 1691
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 508
+ T +E ++ I EQ ER +LL+ Q + +K E +
Sbjct: 1692 EELRAT------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ 1739
Query: 509 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
+ + ++ + L+ R+ K + + + E LK E + +HL+ K+
Sbjct: 1740 ---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN---- 1791
Query: 569 SAVEQTAESCEV------QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
+EQT + ++ Q LK + + LE EL E+ E K + + +
Sbjct: 1792 --MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV---ESEQKRNAEAVKGL 1846
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 682
K +KE+ +Q E+ + L+LQ+ + A++K K E E+Q + A
Sbjct: 1847 RKHERRVKELT-YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA----- 1900
Query: 683 NQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 716
+L+ + + EE+ E Q+ L + +E
Sbjct: 1901 --KFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 58.5 bits (140), Expect = 3e-08
Identities = 126/652 (19%), Positives = 259/652 (39%), Gaps = 88/652 (13%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSVS 218
+E R+L E KAK++ + L+S ++Y+E++ AE AL T V+
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA--NTEVA 1375
Query: 219 PGDTEPMIRA------LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 272
T+ A LEE K + L EE + K LE + + + D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT--KQRLQNEVED 1433
Query: 273 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 332
T N + +D+ ++N + + + T A L +
Sbjct: 1434 LMLDVERT----------NAACAALDKKQRNF--DKILAEWKQKCEETHAELEASQKEAR 1481
Query: 333 HITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
+ E L N ++ S N + ++ LTE+I + + H +
Sbjct: 1482 SLGTE-----LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1536
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE---QLSQENEKLMNLLQ 448
+ QE + Q ++E A E +E IL ++ ++E ++++++E++ L +
Sbjct: 1537 KQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 449 ERVKNEEP--TTQEGKI------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEE 500
++ E +T + +I I L++K G L E E LN ++ +
Sbjct: 1595 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN----EMEIQLNHANRMAAEALRNYR 1650
Query: 501 ENQGALE----MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
QG L+ + E L E L + N++ +EE R TLE + +
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 557 HLQGEKQKA----TEASAVEQTAESCE---------VQEMLKVARAEKDLLELSCNE--- 600
L ++ T+ +++ T + E ++++L+ AR ++ + + +
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESD 655
+ +EL K H+ + +E+ L+ D +AEQL+ + KL+ + E +
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELE 1829
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
E++ ++ E + +H E ++++L++ L+ ++K+ +Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 716 EETEE-------WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 757
E E+ +R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 93.6 bits (231), Expect = 9e-19
Identities = 141/631 (22%), Positives = 258/631 (40%), Gaps = 103/631 (16%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN---------SEGA--ASH 269
+TE + ++E+ + + EL+ E + + L+EK++ L N +EG A
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 270 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 329
D T I E+ T + + D +E NA T+ + + L D
Sbjct: 910 RCDQLIKTKIQLEAKIKEVT--ERAEDEEEI------NAELTAKKRKLEDECSELKKDID 961
Query: 330 DFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAE 389
D E +T + +T N K+ AG + ++A LT++ + ++E H T +
Sbjct: 962 DLE-LTLAKVEKEKHATENKVKNLTEEMAG------LDETIAKLTKEKKALQEAHQQTLD 1014
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL---MNL 446
+LQA ++ V LT KL + LE S Q ++ L + KL + L
Sbjct: 1015 DLQA-------EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKL 1067
Query: 447 LQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGAL 506
QE + + E Q +L++K L++ FE + N+Q K+E+E +
Sbjct: 1068 AQESIMDIENEKQ-----QLDEK----LKKKEFE---ISNLQS-------KIEDEQALGI 1108
Query: 507 EMIKRLKE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKS 556
++ K++KE E+L E +E ER + +++ LEE E L+ G+ +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS---ERLEEAGGATSA 1165
Query: 557 HLQGEKQKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQ 603
++ K++ E + + E +Q A K D L+ +L +
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKE 663
E + EI ++S + V K L+++C +QLS +L+ K E I D+
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS----ELKSKEEEQQRLINDLTA 1281
Query: 664 TIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ---------- 713
L+ + + L+S+L +Q +L+RQL+ K
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQS 1341
Query: 714 -------MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQK 765
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1401
Query: 766 ELGDVQGHGRVVTSRAAPPPVDEEPESSEVD 796
L + H V ++ A ++ +EV+
Sbjct: 1402 RLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432
Score = 81.3 bits (199), Expect = 5e-15
Identities = 137/633 (21%), Positives = 254/633 (40%), Gaps = 81/633 (12%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 1001 EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ-------VDDLEGSLEQEKKLRMD 1053
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E R LE K Q+ + D+E E + L EKL E S+ + I
Sbjct: 1054 LERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI-----------SNLQSKIED 1102
Query: 282 ESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSR 341
E + G Q+ I E + I +S +A SD SR
Sbjct: 1103 EQALGI----QLQKKIKELQARIEELEEEIEAERAS---RAKAEKQRSDL--------SR 1147
Query: 342 PLSSTSNPFKSSKCSTAGS-SPNSVSELSLASLTEKIQKMEENHHSTAEELQAT-LQELS 399
L S + + +T+ N E + +++ H +TA L+ ++
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 400 DQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQEN---EKLMNLLQERVKNEEP 456
+ + + L +KL EK+ ++ E +S+ EK+ L++++ +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 457 TTQEGKIIELE---QKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKRLK 513
+E + + + Q+ E G F R+ L+ ++ L L + ++ +E +KR
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQ--LDEKEALVSQLSRGKQAFTQQIEELKRQL 1325
Query: 514 EENEK----LNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKA-TEA 568
EE K L L+ RH+ +++ + EE + + K+ LQ KA TE
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQES-----------KAELQRALSKANTEV 1374
Query: 569 SAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSY 628
+ E+ +Q ++ A+K +L Q L A ++ V++ A +EK
Sbjct: 1375 AQWRTKYETDAIQRTEELEEAKK--------KLAQRLQAAEEHVEAVNAKCASLEKTKQR 1426
Query: 629 LKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMK----ETIFELEDQVEQHRAVKLH 681
L+ + + RT+ L +K D + + K ET ELE ++ R++
Sbjct: 1427 LQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTE 1486
Query: 682 NNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDI 738
++ + E S+ +LE K + L++++ LT+Q+ E + +L+
Sbjct: 1487 LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH----ELEKIKKQVEQE 1542
Query: 739 KCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
KCE Q L + L EE K R+Q EL V+
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILRIQLELNQVK 1575
Score = 76.3 bits (186), Expect = 1e-13
Identities = 133/640 (20%), Positives = 251/640 (39%), Gaps = 94/640 (14%)
Query: 145 KHLRTPSTKPKQENEGGEKAA------LESQVRELLAEAKAKDSEINRLRSELKKYKEKR 198
K LR + K++ EG K A +E++ ++L + K K+ EI+ L+S K ++++
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQS---KIEDEQ 1104
Query: 199 TLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLE 258
L + L + + E I A +K+ SDL E + E+L
Sbjct: 1105 ALGIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1156
Query: 259 HSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSD 318
+ GA S + + +E+ F +M D++E A +
Sbjct: 1157 --EEAGGATS----AQIEMNKKREAEF-----QKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 319 VTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQ 378
V A L + + + + S + LAS E +
Sbjct: 1206 V--AELGEQIDNLQRVKQKLEKE------------------KSEMKMEIDDLASNVETVS 1245
Query: 379 KMEENHHSTAEELQATLQELS----DQQQMVQELTAENEKLVDEKTILETSFHQHRERAE 434
K + N L+ L EL +QQ+++ +LTA+ +L E +
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVS 1305
Query: 435 QLS-------QENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNI 487
QLS Q+ E+L L+E +K + + C + EQ E+E +
Sbjct: 1306 QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA--LQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 488 QQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGL 547
Q+ L+ + +V + R K E + + ELE + A+ L+ +E +
Sbjct: 1364 QRALSKANTEVAQW---------RTKYETDAIQRTEELEEAKKKL-AQRLQAAEEHVEAV 1413
Query: 548 KMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS--CNELRQE 604
+ SL+ Q + + + VE+T +C + K +K L E C E E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK-KQRNFDKILAEWKQKCEETHAE 1472
Query: 605 LLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKET 664
L + E + + + L K++ Y +E D Q E L R + LQ++ S+ +I + +
Sbjct: 1473 LEASQKEARSLGTELFKIKNAY---EESLD-QLETLKRENKNLQQEISDLTEQIAEGGKR 1528
Query: 665 IFELEDQVEQHRAVKLHNNQLISELESSV-----------IKLEEQKSDLERQLKTLTKQ 713
I ELE +Q K + E E+S+ ++L + KS+++R++ +
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI----AE 1584
Query: 714 MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKL 753
EE ++ +R + ++ D + ++ + +K+K+
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1624
Score = 73.9 bits (180), Expect = 7e-13
Identities = 95/406 (23%), Positives = 175/406 (43%), Gaps = 60/406 (14%)
Query: 376 KIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQ 435
K + E+ + EE Q EL+ + +EL + L+ EK L+ Q + AE
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL---QVQAEAEG 903
Query: 436 LSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSL 495
L+ E+ L++ + I+LE K + E+ E E I +LT
Sbjct: 904 LADAEERCDQLIKTK-------------IQLEAKIKEVTERAEDEEE----INAELTAKK 946
Query: 496 RKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLK 555
RK+E+E +K+ ++ E +E E+H K L E L+ + K
Sbjct: 947 RKLEDE----CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 556 SHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDL---LELSCNELRQELLKAN--- 609
LQ Q+ + E+ + + +K+ + DL LE +LR +L +A
Sbjct: 1003 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE-KKLRMDLERAKRKL 1061
Query: 610 -GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKAS---ESDAEIKDMKETI 665
G++K + +E + L E + ++S K++++ + + +IK+++ I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 666 FELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQ 725
ELE+++E RA S K E+Q+SDL R+L+ ++++++E
Sbjct: 1122 EELEEEIEAERA--------------SRAKAEKQRSDLSRELEEISERLEE--------- 1158
Query: 726 ADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNARLQKELGD 769
A T+ + + K EA Q+ R ++ L+ E A L+K+ D
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Score = 63.2 bits (152), Expect = 1e-09
Identities = 80/332 (24%), Positives = 141/332 (42%), Gaps = 68/332 (20%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +K+ + E + K LEE VTL LK +N L
Sbjct: 846 LKSAETEKEMAT-----MKEEFQKIKD----ELAKSEAKRKELEEKMVTL--LKEKN-DL 893
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 953
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 954 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDETIAKLTKEK 1002
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + IKLE+Q DLE L+ K +
Sbjct: 1003 KALQEAHQQTLDDLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQ----------ELRTVKRKLLEEEEKNARLQKELG 768
R+ + DL+ A DI+ E QQ E+ ++ K+ +E+ +LQK++
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 769 DVQGHGRVVTSRAAPPPVDEEPESSEVDAAGR 800
++Q ++E E E + A R
Sbjct: 1116 ELQAR------------IEELEEEIEAERASR 1135
Score = 58.9 bits (141), Expect = 2e-08
Identities = 125/634 (19%), Positives = 235/634 (37%), Gaps = 111/634 (17%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++++S + TK+ + ++ E +K A Q E EA AK + + +
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E L+ E T+A AL++K +NF K L++ +++
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAA-----------------CAALDKKQRNFDKILAEWKQKC 1466
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGN------QMSSDIDEYK 301
+L + S G ++ S+ Q + N ++ I E
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 302 KNIHG-NALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS 360
K IH ++ +A+L + EH E + N KS
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEV------ 1578
Query: 361 SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQ---------------------ELS 399
+ +A E+I +++ NH E +Q+TL E+
Sbjct: 1579 ------DRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 400 DQQQMVQELTAENEK--------LVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERV 451
Q + AE + L D + L+ + + EQL+ E+ NLLQ +
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV-ERRANLLQAEI 1691
Query: 452 KNEEPTTQEGKIIELEQKCTGILEQGRF---EREKLLNIQQQLTCSLRKVEEENQGALEM 508
+ T +E ++ I EQ ER +LL+ Q + +K E +
Sbjct: 1692 EELRAT------LEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD------ 1739
Query: 509 IKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA 568
+ + ++ + L+ R+ K + + + E LK E + +HL+ K+
Sbjct: 1740 ---ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAHLERMKKN---- 1791
Query: 569 SAVEQTAESCEV------QEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKV 622
+EQT + ++ Q LK + + LE EL E+ E K + + +
Sbjct: 1792 --MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV---ESEQKRNAEAVKGL 1846
Query: 623 EKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHN 682
K +KE+ +Q E+ + L+LQ+ + A++K K E E+Q + A
Sbjct: 1847 RKHERRVKELT-YQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLA----- 1900
Query: 683 NQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 716
+L+ + + EE+ E Q+ L + +E
Sbjct: 1901 --KFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932
Score = 58.5 bits (140), Expect = 3e-08
Identities = 126/652 (19%), Positives = 259/652 (39%), Gaps = 88/652 (13%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSVS 218
+E R+L E KAK++ + L+S ++Y+E++ AE AL T V+
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA--NTEVA 1375
Query: 219 PGDTEPMIRA------LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGD 272
T+ A LEE K + L EE + K LE + + + D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT--KQRLQNEVED 1433
Query: 273 SSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFE 332
T N + +D+ ++N + + + T A L +
Sbjct: 1434 LMLDVERT----------NAACAALDKKQRNF--DKILAEWKQKCEETHAELEASQKEAR 1481
Query: 333 HITAETPSRPLSSTSNPFKSSKCSTAG-SSPNSVSELSLASLTEKIQKMEENHHSTAEEL 391
+ E L N ++ S N + ++ LTE+I + + H +
Sbjct: 1482 SLGTE-----LFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1536
Query: 392 QATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAE---QLSQENEKLMNLLQ 448
+ QE + Q ++E A E +E IL ++ ++E ++++++E++ L +
Sbjct: 1537 KQVEQEKCELQAALEEAEASLEH--EEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 449 ERVKNEEP--TTQEGKI------IELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEE 500
++ E +T + +I I L++K G L E E LN ++ +
Sbjct: 1595 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN----EMEIQLNHANRMAAEALRNYR 1650
Query: 501 ENQGALE----MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
QG L+ + E L E L + N++ +EE R TLE + +
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 557 HLQGEKQKA----TEASAVEQTAESCE---------VQEMLKVARAEKDLLELSCNE--- 600
L ++ T+ +++ T + E ++++L+ AR ++ + + +
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLS-----RTSLKLQEKASESD 655
+ +EL K H+ + +E+ L+ D +AEQL+ + KL+ + E +
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD-EAEQLALKGGKKQIQKLEARVRELE 1829
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
E++ ++ E + +H E ++++L++ L+ ++K+ +Q +
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE 1889
Query: 716 EETEE-------WRRFQADLQTAVVVANDIKCEAQQ---ELRTVKRKLLEEE 757
E E+ +R+ Q +L+ A A+ + + + + R V K++ EE
Sbjct: 1890 EAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|19913398 smoothelin isoform a [Homo sapiens]
Length = 940
Score = 92.4 bits (228), Expect = 2e-18
Identities = 42/98 (42%), Positives = 64/98 (65%), Gaps = 1/98 (1%)
Query: 963 SKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRN 1022
S + LL WC+ KT+GY ++DI NFSSSWSDG+AFCAL+H + P Y +L+ Q +++N
Sbjct: 800 SIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPEAFDYGQLSPQNRRQN 859
Query: 1023 LLLAFEAAESVGIKPS-LELSEMLYTDRPDWQSVMQYV 1059
+AF +AE+ P L+ +M+ PDW+ ++ V
Sbjct: 860 FEVAFSSAETHADCPQLLDTEDMVRLREPDWKMLVDCV 897
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 92.0 bits (227), Expect = 3e-18
Identities = 97/417 (23%), Positives = 188/417 (45%), Gaps = 42/417 (10%)
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQL 436
+ K+E+ H+T +++ +E++ +++ +LT E + L + H++ + L
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA----------HQQALDDL 1010
Query: 437 SQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 496
E +K+ L + +VK E+ +E E+K LE+ + + E L + Q+ S+
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE---SIM 1067
Query: 497 KVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGS--- 553
+E + Q E +K+ E LN +E E+ + + K L+E + +E L+ E +
Sbjct: 1068 DLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Query: 554 -------LKSHLQGEKQKATEASAVEQTAESCEVQ-EMLKVARAEKDLLELSCNE--LRQ 603
L+S L E ++ +E +E+ + VQ EM K AE + E L+
Sbjct: 1128 ARAKVEKLRSDLSRELEEISER--LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1185
Query: 604 ELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIK---D 660
E A KH S+ A++ + L+ + ++ S L+L + S + IK +
Sbjct: 1186 EATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 661 MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQL-------KTLTKQ 713
+++ LEDQ+ +HR+ + +++L S KL+ + +L RQL LT+
Sbjct: 1245 LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 714 MKEETEEWRRFQADLQTAVVVANDIK---CEAQQELRTVKRKLLEEEEKNARLQKEL 767
T++ + L+ V N + A+ + ++ + EE E A LQ+ L
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1361
Score = 85.5 bits (210), Expect = 2e-16
Identities = 134/621 (21%), Positives = 244/621 (39%), Gaps = 65/621 (10%)
Query: 157 ENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTS 216
E E + LE R+L + K I L ++ ++ E+ +AL ++
Sbjct: 1039 EQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE--- 1095
Query: 217 VSPGDTEPMIRALEEKNKNFQKELSDLEEE---NRVLKEKLIYLEH--SPNSEGAASHTG 271
D + + L++K K Q + +LEEE R + K+ L S E +
Sbjct: 1096 ----DEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLE 1151
Query: 272 DSSCPTSITQESSFGSPTGNQ-MSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASD 330
++ TS+ E + Q M D++E A + V A L +
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV--AELGEQIDN 1209
Query: 331 FEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSV-SELSLASLTEKIQKMEENHHSTAE 389
+ + + L + FK + + ++ +L + ++ H S AE
Sbjct: 1210 LQRV-----KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE 1264
Query: 390 ELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE 449
E Q ++ +L+ Q+ +Q E + +DEK E Q +Q+ E L L+E
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEK---EALISQLTRGKLTYTQQLEDLKRQLEE 1321
Query: 450 RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMI 509
VK + + C + EQ E E +Q+ L+ + +V +
Sbjct: 1322 EVKAKNALAH--ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ--------- 1370
Query: 510 KRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL---KSHLQGEKQKA- 565
R K E + + ELE +A+ L+E +E + + SL K LQ E +
Sbjct: 1371 WRTKYETDAIQRTEELEEAKKK-LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1429
Query: 566 --TEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVE 623
E S A + + K+ K E E + EL + E + +S+ L K++
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYE----ESQSELESSQKEARSLSTELFKLK 1485
Query: 624 KDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNN 683
Y +E +H E R + LQE+ S+ ++ +TI ELE +Q A K+
Sbjct: 1486 NAY---EESLEH-LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ 1541
Query: 684 QLISELESSV-----------IKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAV 732
+ E E+S+ ++ + K+++ER+L ++M++ R LQT++
Sbjct: 1542 SALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSL 1601
Query: 733 VVANDIKCEAQQELRTVKRKL 753
D + ++ E VK+K+
Sbjct: 1602 ----DAETRSRNEALRVKKKM 1618
Score = 72.0 bits (175), Expect = 3e-12
Identities = 122/636 (19%), Positives = 260/636 (40%), Gaps = 87/636 (13%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK AL+ ++ L + +A++ ++N L K +++ D L +++ D
Sbjct: 995 EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ-------VDDLEGSLEQEKKVRMD 1047
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQ 281
E R LE K Q+ + DLE + + L E+L + N+ A I
Sbjct: 1048 LERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR-----------IED 1096
Query: 282 ESSFGSPTGN---QMSSDIDEYKKNIHGNALRTSGSS----SSDVTK------------- 321
E + GS ++ + I+E ++ + A RT+ + SD+++
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELE--AERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 322 --ASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQK 379
S+ + + + R L + +++ + +SV+EL + +Q+
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG--EQIDNLQR 1212
Query: 380 MEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQE 439
+++ E + L +++ + + + A EK+ LE ++HR +AE+ +
Sbjct: 1213 VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC---RTLEDQMNEHRSKAEETQRS 1269
Query: 440 NEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVE 499
+ +L +R K + + + ++ ++ L +G+ L QQL R++E
Sbjct: 1270 ---VNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGK------LTYTQQLEDLKRQLE 1320
Query: 500 EENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQ 559
EE +K +N L L+ RH+ +++ + EE L+ S +
Sbjct: 1321 EE----------VKAKNA-LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 560 GEKQKATEASAVEQTAESCEVQEML--KVARAEK--DLLELSCNELRQELLKANGEIKHV 615
+ K E A+++T E E ++ L ++ AE+ + + C+ L + + EI+
Sbjct: 1370 QWRTKY-ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE-- 1426
Query: 616 SSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQH 675
L+ VE+ + + D + + + ++K ES +E++ ++ L ++ +
Sbjct: 1427 -DLMVDVERSNAAAAAL-DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 676 RAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVA 735
+ + + + + L+E+ SDL QL + K + E + ++ +A+
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE-------- 1536
Query: 736 NDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQ 771
K E Q L + L EE K R Q E ++
Sbjct: 1537 ---KMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569
Score = 65.5 bits (158), Expect = 3e-10
Identities = 132/641 (20%), Positives = 266/641 (41%), Gaps = 98/641 (15%)
Query: 166 LESQVRELLAEAKAKDSEINRLRSEL-------KKYKEKRTLNAEGTDALGPNVDGTSV- 217
LE R+L E KAK++ + L+S ++Y+E+ AE L +
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 218 -SPGDTEPMIRA--LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN------SEGAAS 268
+ +T+ + R LEE K + L + EE + K LE + + +
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Query: 269 HTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDA 328
++ ++ ++ + +E + + + + + S S+++ K + +
Sbjct: 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ-KEARSLSTELFKLKNAYEE 1490
Query: 329 SDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTA 388
S EH+ ET R + S GSS ++ EL + +KME S
Sbjct: 1491 S-LEHL--ETFKRENKNLQEEI-SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQ--SAL 1544
Query: 389 EELQATLQ----ELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLM 444
EE +A+L+ ++ Q ++ AE E+ + EK E EQ + + +++
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD----------EEMEQAKRNHLRVV 1594
Query: 445 NLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE---REKLLNIQQQLTCSLRKVEEE 501
+ LQ + E T + + +++K G L + + ++ Q+ SL+ + ++
Sbjct: 1595 DSLQTSLDAE--TRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652
Query: 502 NQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGE 561
Q L+ R N+ L E + + NN++ LEE R +E Q E
Sbjct: 1653 TQIQLDDAVRA---NDDLKENIAIVERRNNLLQAELEELRAVVE-------------QTE 1696
Query: 562 KQKATEASAVEQTAESCEVQEMLKVARA-EKDLLELSCNELRQELLKANGEIKHVSSLLA 620
+ + + +T+E ++ + +K ++ ++L+ E+ +A E ++
Sbjct: 1697 RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAK 1756
Query: 621 KVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKL 680
K D + + AE+L K Q+ ++ + K+M++TI +L+ ++++ + L
Sbjct: 1757 KAITDAAMM-------AEELK----KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Query: 681 H-NNQLISELESSVIKLE-----EQKSDL---------ERQLKTLTKQMKEETEEWRRFQ 725
+ + +LE+ V +LE EQK + ER++K LT Q +E+ + R Q
Sbjct: 1806 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865
Query: 726 ADLQTAVVVANDIKCEAQQELRTVKRKLLE-EEEKNARLQK 765
D+ + Q +++ KR+ E EE+ N L K
Sbjct: 1866 -----------DLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1895
Score = 62.0 bits (149), Expect = 3e-09
Identities = 78/367 (21%), Positives = 162/367 (44%), Gaps = 44/367 (11%)
Query: 437 SQENEKLMNLLQERVKN--EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCS 494
S E EK M ++E E E + ELE+K +L++ + ++ Q L +
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
+ ++ + +++ ++KE NE+L + E+ K +EC LK + L
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC----SELKRDIDDL 957
Query: 555 KSHL-QGEKQK-ATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEI 612
+ L + EK+K ATE T E + E++ EK L+ + + +L ++
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 613 KHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELED-- 670
++ K+E+ L + EQ + + L+ + + ++K +E+I +LE+
Sbjct: 1018 NTLTKAKVKLEQQVDDL----EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 671 -------------------QVEQHRAVKLHNNQLISELESSVIKLEEQ-------KSDLE 704
++E +A+ + + EL++ + +LEE+ ++ +E
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 705 RQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEA--QQELRTVKRKLLEEEEKNAR 762
+ L+++++E +E R +A T+V + + K EA Q+ R ++ L+ E A
Sbjct: 1134 KLRSDLSRELEEISE--RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAA 1191
Query: 763 LQKELGD 769
L+K+ D
Sbjct: 1192 LRKKHAD 1198
Score = 60.1 bits (144), Expect = 1e-08
Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 46/288 (15%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +L E LE + K LEE V+L E L
Sbjct: 840 LKSAEREKEMA-----SMKEEFTRLKEALE----KSEARRKELEEKMVSL---LQEKNDL 887
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E+ +A + V++ E E +E + A+K LE C
Sbjct: 888 QLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDEC 947
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 948 SELKRD-------IDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDEIIAKLTKEK 996
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + +KLE+Q DLE L+ K +
Sbjct: 997 KALQEAHQQALDDLQAEE-------DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE 766
R+ + DL+ D++ + QQ +K+K E NAR++ E
Sbjct: 1050 RAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Score = 57.8 bits (138), Expect = 5e-08
Identities = 116/615 (18%), Positives = 234/615 (38%), Gaps = 63/615 (10%)
Query: 129 RKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEA-KAKDSEINRL 187
++ +S S TK+ + ++ E +K A Q E EA AK S + +
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417
Query: 188 RSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEEN 247
+ L+ E ++ E ++A +D + + ++ ++K + Q EL ++E
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQ---RNFDKILAEWKQKYEESQSELESSQKEA 1474
Query: 248 RVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGN 307
R L +L L+++ E + H QE SD+ E
Sbjct: 1475 RSLSTELFKLKNA--YEESLEHLETFKRENKNLQEEI----------SDLTEQ------- 1515
Query: 308 ALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSE 367
L +SG + ++ K +A E + + S K + + + E
Sbjct: 1516 -LGSSGKTIHELEKVRKQLEAEKME-LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Query: 368 LSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFH 427
LA E++++ + NH + LQ +L + + E +K+ + +E
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDA---ETRSRNEALRVKKKMEGDLNEMEIQLS 1630
Query: 428 QHRERAEQLSQENEKLMNLLQE-RVKNEEPTTQEGKI---IELEQKCTGILEQGRFEREK 483
A + ++ + L +LL++ +++ ++ + I + ++ +L+ E E+
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---ELEE 1687
Query: 484 LLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKL------------------NEFLEL 525
L + +Q S + E+E E ++ L +N L E ++
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 526 ERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLK 585
R+ K + + + E LK E + +HL E+ K ++ + E +
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDT-SAHL--ERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 586 VARAEKDL--LELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRT 643
+ +K L LE EL EL E K + + + K +KE+ +Q E+ +
Sbjct: 1805 LKGGKKQLQKLEARVRELENEL---EAEQKRNAESVKGMRKSERRIKELT-YQTEEDRKN 1860
Query: 644 SLKLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDL 703
L+LQ+ + ++K K E E+Q + + + E E E Q + L
Sbjct: 1861 LLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920
Query: 704 ERQLKTL-TKQMKEE 717
+ + + TK + EE
Sbjct: 1921 RAKSRDIGTKGLNEE 1935
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 91.7 bits (226), Expect = 3e-18
Identities = 201/871 (23%), Positives = 343/871 (39%), Gaps = 111/871 (12%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLR----SELKKYKEKRTLNAEGTDALG----PNVD 213
E A L+ + L E + KD E+ +LR +++K+ +E R + + L +
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHAS 1103
Query: 214 GT---SVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHT 270
G+ S + G TEP LE + E+S LE++ + +E+ LE S +E A+
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEA----LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 271 GDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASD 330
DS+ T Q G+ S+ ++ S + D KA ++ +
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219
Query: 331 FEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEEN----HHS 386
E + S L + G S + L +A +EK QK+EE
Sbjct: 1220 AERKNSLISS--LEEEVSILNRQVLEKEGES-KELKRLVMAE-SEKSQKLEERLRLLQAE 1275
Query: 387 TAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQE----NEK 442
TA + S ++ VQ L E EK L ERAE+L QE EK
Sbjct: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1335
Query: 443 LMNLLQ--ERVKNEEPTTQE--GKIIELEQKCTGI-LEQGRFEREKLLNIQQQ------L 491
Q ++ E +TQ +++ + C + EQ E+ ++Q L
Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGL 1395
Query: 492 TCSLRKVEEENQGALEMIKRLKEENEKLNEFLELER----HNNNMMAKT----LEECRVT 543
L + + E G L +++ E E+ + L E+ +M+ K EE R
Sbjct: 1396 RAELLRAQRE-LGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1454
Query: 544 LEGLKMENGSLKSHLQGEKQK-ATEASAVEQTAES--CEVQ-------EMLKVARAEKDL 593
E + L+ L ++K E +AV AE+ EVQ L+V A+ +
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 594 LELSCNELRQ----ELLKANGEIKHVSSLLAKVEKDYSYL-KEICD-HQAEQLSRTSLK- 646
++ E RQ E K +++ + + K L K++ D QA ++ + LK
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
Query: 647 LQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQ 706
+Q + ES E + ++ + EL+ Q+ Q H + + ++ ++Q +L+ Q
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 707 LKTLTKQMKEETE---EWRRFQADLQTAVVVANDIKCEAQQELR--TVKRKLLEEEEKNA 761
L++L + KE E E R +LQ A + EA+Q R T + + LE + +A
Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTK----EAEQTCRHLTAQVRSLEAQVAHA 1690
Query: 762 RLQ-KELGDVQGHGRVVTSR--AAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESAT 818
Q ++LG Q + SR A P +D +S ++ P S+ T P+ +
Sbjct: 1691 DQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTS 1750
Query: 819 TVKSLIKSFDLGRPGGAGQNISVHKTPR-SPLSGIPVRTAPAAAVSPMQRH--------- 868
PG IS P+ L + PA + +P++
Sbjct: 1751 V------------PGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFL 1798
Query: 869 STYSSVRPASRGVTQRLDL----------PDLPLSDILKGRTETLKPDPHLRKSPSLESL 918
+ R A R TQ +++ PD S R+ LR + S +SL
Sbjct: 1799 DSGRKTRSARRRTTQIINITMTKKLDVEEPDSANSSFYSTRSAPAS-QASLRATSSTQSL 1857
Query: 919 SRPPSLGFGDTRLLSASTRAWKPQSKLSVER 949
+R S +G++ LLS ++P ++ S R
Sbjct: 1858 ARLGSPDYGNSALLSLP--GYRPTTRSSARR 1886
Score = 77.8 bits (190), Expect = 5e-14
Identities = 123/565 (21%), Positives = 237/565 (41%), Gaps = 69/565 (12%)
Query: 227 RALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFG 286
+ LEEKN+ Q +LS LEE L+ ++ P +G GD ++ QE++
Sbjct: 374 KCLEEKNEILQGKLSQLEEHLSQLQ------DNPPQEKGEV--LGDVLQLETLKQEAATL 425
Query: 287 SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSST 346
+ Q+ + ++ L T +A L + FE + LSS
Sbjct: 426 AANNTQLQARVE---------MLETERGQQ----EAKLLAERGHFEE-----EKQQLSSL 467
Query: 347 SNPFKS--SKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQM 404
+S S S A S+ A LT ++ + + +Q QEL+ +Q
Sbjct: 468 ITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527
Query: 405 VQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKII 464
+E A+ + + ++ E + R + EQLS ++ L+E + +E T Q+
Sbjct: 528 AKEKQAQLAQTLQQQ---EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQD---- 580
Query: 465 ELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALEMIKR----LKEENEKLN 520
+Q T E+ RE+ ++Q L +E+E LE++++ E +
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQ-----LEALEKEKAAKLEILQQQLQVANEARDSAQ 635
Query: 521 EFLELERHNNNMMAKTLEECRVTLEGLKMEN-------GSLKSHLQGEKQKATEASAVEQ 573
+ + +++ +EE + +E + E L+ L+ E+QKATE V Q
Sbjct: 636 TSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ 695
Query: 574 TAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKHVSSLLAKVEKDYSYL---- 629
E ++QE L +A K+ L+++ L +E +A ++ +++++ + L
Sbjct: 696 --EKDQLQEQL---QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 630 -KEICDHQAEQLSRTSL--KLQEKASESDAEIKDMKETIFELEDQVEQHRAVKLHNNQLI 686
+E + + E+ R L +LQ+ AE + ++ EL + + + QL+
Sbjct: 751 KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR---ELAEAMAAQHTAESECEQLV 807
Query: 687 SELESSVIKLEEQKSDLERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQEL 746
E+ + + E+ + + + +Q+ EE + + +LQ A I E+ EL
Sbjct: 808 KEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGI--ESHSEL 865
Query: 747 RTVKRKLLEEEEKNARLQKELGDVQ 771
+ + R+ E E +A L + L VQ
Sbjct: 866 Q-ISRQQNELAELHANLARALQQVQ 889
Score = 74.7 bits (182), Expect = 4e-13
Identities = 140/666 (21%), Positives = 268/666 (40%), Gaps = 70/666 (10%)
Query: 162 EKAALESQVRELLA----------EAKAKDSEIN-RLRSELKKYKEKRTLNAEGTDALGP 210
EKA L +V EL A EA+A+ +E+ +LRSE +K EK + A+ D L
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERV-AQEKDQLQE 702
Query: 211 NV----DGTSVSPGDTEPMIRALEEKNKNFQKELSDLEEENRVLKE------KLIYLEHS 260
+ + V+ G E R + + Q+ +S+L+ E R L E K + E +
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 261 PNS--EGAASHTGDSSCPTS--ITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSS 316
E G++ + + +E + + S+ ++ K + R S
Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 317 SDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEK 376
+ ++ + T + +K AG +S ++S +
Sbjct: 823 EEAQYGAMFQEQ-------LMTLKEECEKARQELQEAKEKVAGIESHSELQIS-----RQ 870
Query: 377 IQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLV---DEKTILETSFHQHRERA 433
++ E H + A LQ ++ Q++ +L+ EK+ E LET + E+
Sbjct: 871 QNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQ 930
Query: 434 EQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTC 493
E S+E K +R + E Q+G+ Q +E+ E E++ N ++L
Sbjct: 931 ETASRELVKEPARAGDR-QPEWLEEQQGRQFCSTQAALQAMER---EAEQMGNELERLRA 986
Query: 494 SLRKVE---EENQGALEM-IKRLKEENEKLNEFLELER----HNNNMMAKTLEECRVTLE 545
+L + + +E +G E + RL +E + L LE+ + L E RV
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFA 1046
Query: 546 GLKMENGSLKSHLQGEKQ-----KATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE 600
L+ + +G+ Q + EA+ +++ E + + LK A+K+ S +
Sbjct: 1047 TLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSG 1106
Query: 601 LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQ-EKASESDAEIK 659
+ E A G + L + + S L++ C Q EQ L+ E+AS ++ +
Sbjct: 1107 AQSE---AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERD-- 1161
Query: 660 DMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSD---LERQLKTLTKQMKE 716
+ L+ Q+E+ H+ ++ + + + D E + K + ++
Sbjct: 1162 ---SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
Query: 717 ETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRV 776
E E + L+ V + N E + E + +KR ++ E EK+ +L++ L +Q
Sbjct: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETAS 1278
Query: 777 VTSRAA 782
++RAA
Sbjct: 1279 NSARAA 1284
Score = 73.9 bits (180), Expect = 7e-13
Identities = 98/461 (21%), Positives = 194/461 (42%), Gaps = 74/461 (16%)
Query: 360 SSPNSVSELSLASLTEKIQKMEEN-HHSTAEELQATLQELSDQQQMVQELTA--ENEKLV 416
S N L +Q++++ + T E +AT + L Q Q+ +EL+A +++K +
Sbjct: 317 SEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 417 DEKT-ILETSFHQHRERAEQLS-----QENEKLMNLLQ-ERVKNEEPT-----TQEGKII 464
+EK IL+ Q E QL ++ E L ++LQ E +K E T TQ +
Sbjct: 377 EEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARV 436
Query: 465 EL------EQKCTGILEQGRFEREK-----LLNIQQQLTCSLRKVEEENQGALE------ 507
E+ +Q+ + E+G FE EK L+ Q +L + +EE + A +
Sbjct: 437 EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARL 496
Query: 508 -------------MIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
+ +++++++L + + +A+TL++ +GL+ + L
Sbjct: 497 TAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQL 556
Query: 555 KSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNELRQELLKANGEIKH 614
S L+ ++Q+ E + ++ Q++ A E L + + +K
Sbjct: 557 SSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE-----------EREASLRERDAALKQ 605
Query: 615 VSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKDMKETIFELEDQVEQ 674
+ +L EK+ + EI Q + + Q +++ E ++ + EL+ VE
Sbjct: 606 LEAL----EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVET 661
Query: 675 HRAVKLHNNQLISELESSVI----------KLEEQKSDLERQLKTLTKQMKEET----EE 720
R + ++ELE + ++ ++K L+ QL+ L + +K EE
Sbjct: 662 ARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEE 721
Query: 721 WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNA 761
RR L+ +++K E + + KR+ E EE+ A
Sbjct: 722 KRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Score = 71.6 bits (174), Expect = 4e-12
Identities = 131/657 (19%), Positives = 257/657 (39%), Gaps = 81/657 (12%)
Query: 155 KQENEGGEKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDG 214
K E G+ + LE + +L + E+ +L+ K++ A L V+
Sbjct: 379 KNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
Query: 215 TSVSPGDTEPMIRA----LEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPNSEGAASHT 270
G E + A EE+ + ++DL+ L + LE + + GA
Sbjct: 439 LETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTA 498
Query: 271 GDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASD 330
+S + +T +++ I + + + G + + AS
Sbjct: 499 QVASLTSELTT-----------LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 331 FEHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEE 390
E S L K + + +L+ A+ + E + + ++
Sbjct: 548 GLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD--AALKQ 605
Query: 391 LQATLQELSDQQQMVQE-LTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQE 449
L+A +E + + +++Q+ L NE + +TS Q + +LS++ E+L ++
Sbjct: 606 LEALEKEKAAKLEILQQQLQVANEA----RDSAQTSVTQAQREKAELSRKVEELQACVE- 660
Query: 450 RVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEE---NQGAL 506
+E + ++ ELE + +Q E+E++ + QL L+ ++E +G+L
Sbjct: 661 -TARQEQHEAQAQVAELELQLRSE-QQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL 718
Query: 507 EMIKR-----LKEENEKLNEFLE-----LERHNNNMMAKTLEECRVTLEGLKMENGSLKS 556
E KR L+E+ ++E +E+H K LEE R +GL+ L
Sbjct: 719 EEEKRRAADALEEQQRCISELKAETRSLVEQHKRER--KELEEERAGRKGLEARLQQLGE 776
Query: 557 HLQGE----KQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE------------ 600
Q E +++ EA A + TAES E ++++K A ++ E S E
Sbjct: 777 AHQAETEVLRRELAEAMAAQHTAES-ECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQL 835
Query: 601 --LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQE---KASESD 655
L++E KA E++ +A +E H Q+SR +L E + +
Sbjct: 836 MTLKEECEKARQELQEAKEKVAGIES----------HSELQISRQQNELAELHANLARAL 885
Query: 656 AEIKDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMK 715
++++ + +L D + + ++ ++ LE+ V K EQ+ R+L +
Sbjct: 886 QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG 945
Query: 716 EETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQG 772
+ EW Q Q C Q L+ ++R+ + + RL+ L + QG
Sbjct: 946 DRQPEWLEEQQGRQF---------CSTQAALQAMEREAEQMGNELERLRAALMESQG 993
Score = 67.0 bits (162), Expect = 9e-11
Identities = 97/410 (23%), Positives = 174/410 (42%), Gaps = 46/410 (11%)
Query: 370 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 429
L L +K + + H T ++ Q E S + + +L+ EN L + + Q
Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337
Query: 430 RERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQ 489
++ +L++E+ K QE ++ + +E ++KC + E+ + KL +++
Sbjct: 338 QDALNELTEEHSKAT---QEWLEKQAQLEKELSAALQDKKC--LEEKNEILQGKLSQLEE 392
Query: 490 ---QLTCSLRKVEEENQGALEMIKRLKEE-------NEKLNEFLE-LERHNNNMMAKTLE 538
QL + + + E G + ++ LK+E N +L +E LE AK L
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
Query: 539 ECRVTLEGLKMENGSLKSHLQGEKQKATEASA-VEQTAESCEVQEMLKVARAEKDLLELS 597
E R E K + SL + LQ ++A +EQ +++ + +VA +L L+
Sbjct: 453 E-RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLN 511
Query: 598 CN--ELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESD 655
+ QEL + K + LA+ + + HQ EQLS +SLK +E+
Sbjct: 512 ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS-SSLKQKEQ----- 565
Query: 656 AEIKDMKETIFELEDQVEQHRAVKL-HNNQLISELESSVIKLEEQKSDLERQLKTLTKQM 714
+L++ E+ A + H QL + E L E+ + L +QL+ L K+
Sbjct: 566 -----------QLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL-KQLEALEKEK 613
Query: 715 KEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQ 764
+ E LQ + VAN+ + AQ + +R+ E K LQ
Sbjct: 614 AAKLEI-------LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Score = 66.2 bits (160), Expect = 2e-10
Identities = 116/508 (22%), Positives = 216/508 (42%), Gaps = 85/508 (16%)
Query: 367 ELSLASLTEKIQKMEE-NHHSTAEELQAT-LQELSDQQQMVQELTAENEKLVDEKTILET 424
+ +A + ++I ++ N A L+ L+EL D+ + LT + + + L+T
Sbjct: 248 DAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNE---SLTMRLHETLKQCQDLKT 304
Query: 425 SFHQHRERAEQLSQEN--------------EKLMNLLQERVKNEEPTTQE--GKIIELEQ 468
Q + QLS+EN ++L + L E + TQE K +LE+
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364
Query: 469 KCTGILEQGRFEREKLLNIQ---QQLTCSLRKVEE-------ENQGALEMIKRLKEE--- 515
+ + L+ + EK +Q QL L ++++ E G + ++ LK+E
Sbjct: 365 ELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT 424
Query: 516 ----NEKLNEFLE-LERHNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEA-S 569
N +L +E LE AK L E R E K + SL + LQ ++A
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAE-RGHFEEEKQQLSSLITDLQSSISNLSQAKE 483
Query: 570 AVEQTAESCEVQEMLKVARAEKDL--LELSCNELRQELLKANGEIKHVSSLLAKVEKDYS 627
+EQ +++ + +VA +L L + + QEL + K + LA+ +
Sbjct: 484 ELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQE 543
Query: 628 YLKEICDHQAEQLSRTSLKLQEK-----------------------ASESDAEIKDMKET 664
+ HQ EQLS +SLK +E+ A E +A +++
Sbjct: 544 QASQGLRHQVEQLS-SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAA 602
Query: 665 IFELEDQVEQHRAVKLH--------NNQLISELESSVIKLEEQKSDLERQLKTLTKQMKE 716
+ +LE +E+ +A KL N+ ++SV + + +K++L R+++ L Q
Sbjct: 603 LKQLE-ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEEL--QACV 659
Query: 717 ETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE----EEKNARLQKELGDVQG 772
ET + +A Q A + +++ ++Q+ T K ++ +E +E+ L++ L +G
Sbjct: 660 ETARQEQHEAQAQVAEL---ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 773 HGRVVTSRAAPPPVDEEPESSEVDAAGR 800
RAA +++ SE+ A R
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETR 744
>gi|169234649 smoothelin-like 2 isoform 2 [Homo sapiens]
Length = 317
Score = 91.7 bits (226), Expect = 3e-18
Identities = 81/320 (25%), Positives = 137/320 (42%), Gaps = 40/320 (12%)
Query: 764 QKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSL 823
Q G G + + +AP P P S + + P ++R S S T +
Sbjct: 15 QPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQ-PVTAITRVSDR--FSGETSAAA 71
Query: 824 IKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASR--GV 881
+ GG + S TP +P SP +++S+++ P+S V
Sbjct: 72 LSPMSAATLGGLNPSPSEVITPWTP--------------SPSEKNSSFTWSVPSSGYGAV 117
Query: 882 TQR--------LDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLS 933
T + P P+S T+ + R+ ++L R + +
Sbjct: 118 TASKHSNSPPLVTPPQSPVSPQPPAITQVHRQGERRRELVRSQTLPRT-----SEAQARK 172
Query: 934 ASTRAWKPQSKLSVERKDPLAALAREYG------GSKRNALLKWCQKKTQGYANIDITNF 987
A W+ ++ + + A L R S + LL+WC+ KT GY ++D+ NF
Sbjct: 173 ALFEKWEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNF 232
Query: 988 SSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESV-GIKPSLELSEMLY 1046
SSSWSDG+AFCAL+H++ P Y L+ ++++N LAF AE++ + +E+ +M+
Sbjct: 233 SSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMV 292
Query: 1047 TDR-PDWQSVMQYVAQIYKY 1065
R PD V YV +Y +
Sbjct: 293 MGRKPDPMCVFTYVQSLYNH 312
>gi|169234647 smoothelin-like 2 isoform 1 [Homo sapiens]
Length = 461
Score = 91.7 bits (226), Expect = 3e-18
Identities = 81/320 (25%), Positives = 137/320 (42%), Gaps = 40/320 (12%)
Query: 764 QKELGDVQGHGRVVTSRAAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSL 823
Q G G + + +AP P P S + + P ++R S S T +
Sbjct: 159 QPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQ-PVTAITRVSDR--FSGETSAAA 215
Query: 824 IKSFDLGRPGGAGQNISVHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASR--GV 881
+ GG + S TP +P SP +++S+++ P+S V
Sbjct: 216 LSPMSAATLGGLNPSPSEVITPWTP--------------SPSEKNSSFTWSVPSSGYGAV 261
Query: 882 TQR--------LDLPDLPLSDILKGRTETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLS 933
T + P P+S T+ + R+ ++L R + +
Sbjct: 262 TASKHSNSPPLVTPPQSPVSPQPPAITQVHRQGERRRELVRSQTLPRT-----SEAQARK 316
Query: 934 ASTRAWKPQSKLSVERKDPLAALAREYG------GSKRNALLKWCQKKTQGYANIDITNF 987
A W+ ++ + + A L R S + LL+WC+ KT GY ++D+ NF
Sbjct: 317 ALFEKWEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNF 376
Query: 988 SSSWSDGLAFCALLHTYLPAHIPYQELNSQEKKRNLLLAFEAAESV-GIKPSLELSEMLY 1046
SSSWSDG+AFCAL+H++ P Y L+ ++++N LAF AE++ + +E+ +M+
Sbjct: 377 SSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMV 436
Query: 1047 TDR-PDWQSVMQYVAQIYKY 1065
R PD V YV +Y +
Sbjct: 437 MGRKPDPMCVFTYVQSLYNH 456
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 91.3 bits (225), Expect = 4e-18
Identities = 141/628 (22%), Positives = 243/628 (38%), Gaps = 97/628 (15%)
Query: 221 DTEPMIRALEEKNKNFQKELSDLEEENRVLKEKLIYLEHSPN-------SEGAASHTGDS 273
+TE + ++E+ + + EL+ E + + L+EKL+ L N +E +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 274 SCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDASDFEH 333
C I + + DE + NA T+ + + L D D E
Sbjct: 905 RCDQLIKAKFQLEAKIKEVTERAEDEEEI----NAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 334 ITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEENHHSTAEELQA 393
A+ + K +T N ELS L E I K+ + E Q
Sbjct: 961 TLAKV------------EKEKHATENKVKNLTEELS--GLDETIAKLTREKKALQEAHQQ 1006
Query: 394 TLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLLQERVKN 453
L +L ++ V L KL + LE+S Q ++ L + KL
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKL---------- 1056
Query: 454 EEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR-KVEEENQGALEMIKRL 512
EG ++L Q+ LE + + ++ L + C L+ KVE+E L+ K++
Sbjct: 1057 ------EGD-LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI 1109
Query: 513 KE---ENEKLNEFLELER-------HNNNMMAKTLEECRVTLEGLKMENGSLKSHLQGEK 562
KE E+L E +E ER + A+ LEE E L+ G + ++ K
Sbjct: 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELS---ERLEEAGGVTSTQIELNK 1166
Query: 563 QKATEASAVEQTAESCEVQEMLKVARAEK-------------DLLELSCNELRQELLKAN 609
++ E + + E +Q VA K D L+ +L +E +
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLK---LQEKASESDAEIKDMKETIF 666
EI +SS + V K + L++IC +QLS K +Q SE + ++
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 667 ELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQ------------- 713
EL Q+E+ ++ +S+L S +Q +L+RQL+ K
Sbjct: 1287 ELSRQLEEKESI-------VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Query: 714 ----MKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEE-EEKNARLQKELG 768
++E+ EE + +A+LQ A+ AN + + + T + EE EE +L + L
Sbjct: 1340 DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Query: 769 DVQGHGRVVTSRAAPPPVDEEPESSEVD 796
D + V ++ A ++ EV+
Sbjct: 1400 DSEEQVEAVNAKCASLEKTKQRLQGEVE 1427
Score = 76.3 bits (186), Expect = 1e-13
Identities = 130/649 (20%), Positives = 254/649 (39%), Gaps = 86/649 (13%)
Query: 162 EKAALESQVRELLAEAKAKDSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGD 221
EK A E++V+ L E D I +L E K +E + A V+ + +
Sbjct: 968 EKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSK 1027
Query: 222 TEPMIRALEEKNKNFQKELSDLEEENRVLK-------EKLIYLEHSPNSEGAASHTGD-- 272
E + LE + +K DLE R L+ E ++ LE+ D
Sbjct: 1028 LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFE 1087
Query: 273 -SSCPTSITQESSFG---SPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDA 328
+ + E + G ++ + I+E ++ I T+A
Sbjct: 1088 YCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER----------ATRAKTEKQR 1137
Query: 329 SDFEHITAETPSR-----PLSSTSNPFKSSKCSTAGSSPNSVSELSLASLTEKIQKMEEN 383
SD+ E R ++ST + + + E +L + + +
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH-EAMVAALRKK 1196
Query: 384 HHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKL 443
H + EL + L +Q +++ +E + +D+ + S + + E++ + E
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED- 1255
Query: 444 MNLLQERVKNEEP-------TTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLR 496
L + R KNEE TTQ+ ++ Q G L + E+E +++ QL+ S +
Sbjct: 1256 -QLSEARGKNEEIQRSLSELTTQKSRL----QTEAGELSRQLEEKESIVS---QLSRSKQ 1307
Query: 497 KVEEENQGALEMIKRLKEENEKLNEF---LELERHNNNMMAKTLEECRVTLEGLKMENGS 553
++ + E+ ++L+EEN+ N L+ RH+ +++ + EE + L+
Sbjct: 1308 AFTQQTE---ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 554 LKSHLQGEKQKATEASAVEQTAESCEVQ----EMLKVARAEKDLLELSCNELRQELLKAN 609
S + + K E A+++T E E + + L+ + + + + C L + +
Sbjct: 1365 ANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Query: 610 GEIKHVSSLLAKVEKDYSYLKEICDHQA---EQLSRTSLKLQEKASESDAEIKDMKETIF 666
GE++ L+ VE+ S + Q + L+ K +E +E +A +K+ +
Sbjct: 1424 GEVE---DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLST 1480
Query: 667 EL-------EDQVEQHRAVKLHNNQL-----------------ISELESSVIKLEEQKSD 702
EL E+ ++Q VK N L I ELE S ++E +K+D
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAD 1540
Query: 703 LERQLKTLTKQMKEETEEWRRFQADLQTAVVVANDIKCEAQQELRTVKR 751
++ L+ ++ E + R Q +L + E +E+ +KR
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589
Score = 66.6 bits (161), Expect = 1e-10
Identities = 161/731 (22%), Positives = 280/731 (38%), Gaps = 155/731 (21%)
Query: 157 ENEGGEKAALESQVREL---LAEAKAKDSEINRLRSELKKYKEKRTLNA--------EGT 205
E+ KA LE R L L+EA+ K+ EI R SEL K + A E
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 206 DALGPNVDGTSVSPGDTEPMIRALEEKNKN-------FQKELSDLE------EENRVLKE 252
+ TE + R LEE+NK Q D + EE + K
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Query: 253 KLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTS 312
+L NSE A T + T+E Q D +E + ++
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC---- 1412
Query: 313 GSSSSDVTKASLSPDASDF--EHITAETPSRPLSSTSNPFKSSKCSTAGSSPNSVSELSL 370
+S + TK L + D + A + + L F S +EL
Sbjct: 1413 --ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 371 A-----SLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELT---AENEKLVDEKTIL 422
+ SL+ ++ K++ + ++L+ +E + +Q + +LT AEN K +
Sbjct: 1471 SLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI------ 1524
Query: 423 ETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQ-GRFER 481
H+ + +Q+ E + L+E E +E KI+ ++ + T + + R
Sbjct: 1525 ----HELEKSRKQIELEKADIQLALEEAEAALEH--EEAKILRIQLELTQVKSEIDRKIA 1578
Query: 482 EKLLNIQQQLTCSLRKVEEENQGAL--------EMIKRLKEENEKLNEFLELERHNNNMM 533
EK I+Q L + ++ E Q AL E I+ K+ LNE H N
Sbjct: 1579 EKDEEIEQ-LKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637
Query: 534 AKTLEECRVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAE--SCEVQEMLKVARAEK 591
A+TL+ R LK L L+G++ + + VE+ A EV+E+ RA
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL----RATL 1693
Query: 592 DLLELSCNELRQELLKANGEIKHV----SSLL---AKVEKDYSYLKEICDHQAEQLSRTS 644
+ E + QELL +N ++ + +SL+ K+E D L+ + E SR +
Sbjct: 1694 EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS----EVEDASRDA 1749
Query: 645 LKLQEKASES--DAEI-------------------KDMKETIFELEDQVEQHRAVKLHNN 683
+EKA ++ DA + K++++T+ +L+ ++++ + L
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1809
Query: 684 QL-ISELESSVIKLE-----EQKSDLE---------RQLKTLTKQMKEETE--------- 719
+ I +LE+ + +LE EQK + E R++K LT Q +E+ +
Sbjct: 1810 KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV 1869
Query: 720 --------------------------EWRRFQADLQTA-----VVVANDIKCEAQQELRT 748
++R+ Q +L+ A + + K A+ T
Sbjct: 1870 DKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFT 1929
Query: 749 VKRKLLEEEEK 759
R ++ E E+
Sbjct: 1930 SSRMVVHESEE 1940
Score = 55.5 bits (132), Expect = 3e-07
Identities = 75/322 (23%), Positives = 136/322 (42%), Gaps = 49/322 (15%)
Query: 495 LRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEECRVTLEGLKMENGSL 554
L+ E E + A +KEE +K + E + K LEE VTL E L
Sbjct: 841 LKSAETEKEMAT-----MKEEFQKTKD----ELAKSEAKRKELEEKLVTLV---QEKNDL 888
Query: 555 KSHLQGEKQKATEA---------------SAVEQTAESCEVQEMLKVA-RAEKDLLELSC 598
+ +Q E + +A + +++ E E +E + A+K LE C
Sbjct: 889 QLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 948
Query: 599 NELRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEI 658
+EL+++ I + LAKVEK+ K +++ + L+ L E ++ E
Sbjct: 949 SELKKD-------IDDLELTLAKVEKE----KHATENKVKNLTEELSGLDETIAKLTREK 997
Query: 659 KDMKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEET 718
K ++E + D ++ ++ L + KLE+Q DLE L+ K +
Sbjct: 998 KALQEAHQQALDDLQAEE-------DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLE 1050
Query: 719 EEWRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKE--LGDVQGHGRV 776
R+ + DL+ A D++ + QQ +K+K E + ++++ E LG +Q ++
Sbjct: 1051 RNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLG-LQFQKKI 1109
Query: 777 VTSRAAPPPVDEEPESSEVDAA 798
+A ++EE E+ A
Sbjct: 1110 KELQARIEELEEEIEAERATRA 1131
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.123 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,093,871
Number of Sequences: 37866
Number of extensions: 2050322
Number of successful extensions: 23776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 429
Number of HSP's successfully gapped in prelim test: 1386
Number of HSP's that attempted gapping in prelim test: 11396
Number of HSP's gapped (non-prelim): 7741
length of query: 1068
length of database: 18,247,518
effective HSP length: 113
effective length of query: 955
effective length of database: 13,968,660
effective search space: 13340070300
effective search space used: 13340070300
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.