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Search of human proteins with 75677574
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75677574 cell cycle progression 1 isoform 2 [Homo sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75677574 cell cycle progression 1 isoform 2 [Homo sapiens] 1516 0.0
gi|75677585 cell cycle progression 1 isoform 1 [Homo sapiens] 1516 0.0
gi|19923830 pre-B-cell leukemia homeobox interacting protein 1 [... 116 7e-26
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 68 4e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 67 6e-11
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 66 1e-10
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 60 7e-09
gi|50083279 centrosome protein 4 [Homo sapiens] 59 2e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 57 5e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 57 6e-08
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 57 8e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 57 8e-08
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 57 8e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 55 2e-07
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 55 2e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 55 2e-07
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 55 3e-07
gi|238908495 similar to pleckstrin homology domain protein (5V32... 55 3e-07
gi|34878777 ring finger protein 20 [Homo sapiens] 55 3e-07
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 55 3e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 3e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 3e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 3e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 3e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 3e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 3e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 3e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 3e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 54 4e-07
gi|38044112 restin isoform b [Homo sapiens] 54 4e-07
>gi|75677574 cell cycle progression 1 isoform 2 [Homo sapiens]
Length = 757
Score = 1516 bits (3925), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 60
MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES
Sbjct: 1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 60
Query: 61 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 120
SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ
Sbjct: 61 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 120
Query: 121 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 180
EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA
Sbjct: 121 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 180
Query: 181 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI
Sbjct: 181 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK
Sbjct: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
Query: 301 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 360
TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE
Sbjct: 301 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 360
Query: 361 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 420
EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE
Sbjct: 361 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 420
Query: 421 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 480
KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK
Sbjct: 421 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 480
Query: 481 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 540
SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT
Sbjct: 481 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 540
Query: 541 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 600
KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF
Sbjct: 541 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 600
Query: 601 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 660
KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII
Sbjct: 601 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 660
Query: 661 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 720
QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG
Sbjct: 661 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 720
Query: 721 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL 757
VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL
Sbjct: 721 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL 757
>gi|75677585 cell cycle progression 1 isoform 1 [Homo sapiens]
Length = 757
Score = 1516 bits (3925), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 60
MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES
Sbjct: 1 MSENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGES 60
Query: 61 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 120
SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ
Sbjct: 61 SQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQ 120
Query: 121 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 180
EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA
Sbjct: 121 EVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRA 180
Query: 181 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI
Sbjct: 181 RKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK
Sbjct: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
Query: 301 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 360
TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE
Sbjct: 301 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 360
Query: 361 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 420
EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE
Sbjct: 361 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE 420
Query: 421 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 480
KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK
Sbjct: 421 KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK 480
Query: 481 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 540
SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT
Sbjct: 481 SKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTT 540
Query: 541 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 600
KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF
Sbjct: 541 KNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHF 600
Query: 601 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 660
KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII
Sbjct: 601 KEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQII 660
Query: 661 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 720
QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG
Sbjct: 661 QRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDG 720
Query: 721 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL 757
VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL
Sbjct: 721 VFEKLDEYIYRHFFGHTFSPPYGPRSVYIKPCHYSSL 757
>gi|19923830 pre-B-cell leukemia homeobox interacting protein 1
[Homo sapiens]
Length = 731
Score = 116 bits (291), Expect = 7e-26
Identities = 172/771 (22%), Positives = 309/771 (40%), Gaps = 124/771 (16%)
Query: 7 DSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGESSQNGTV 66
DSD+S W + E +E L PA S ++ E +ALQ S +G
Sbjct: 6 DSDNS--WVLAGSESLPVETLG---------PA---SRMDPESERALQAPHSPSKTDGKE 51
Query: 67 LM-----EETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEI---G 118
L E T + S +I EE ++ GT + D+ +EPP + G
Sbjct: 52 LAGTMDGEGTLFQTESPQSGSILTEETEVK------GTL--EGDVCGVEPPGPGDTVVQG 103
Query: 119 NQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRR 178
+ + V + ++ S Q P+ + + SS D+T + RRR
Sbjct: 104 DLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDT-DVDMEGLRRR 162
Query: 179 RARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTI 238
R R+ A + + E + E + + LN C++ ALV+ + +G F G +
Sbjct: 163 RGRE----AGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVL-LGLGVLLFSGGL 217
Query: 239 QIQKR---QQLVRKIHEDE-----LNDMKDYLSQCQQ-----------EQESFIDYKSLK 279
+ +++ R++ D + D +D L + Q + + K K
Sbjct: 218 SESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAK 277
Query: 280 EN-----LARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQ 334
EN L + E S Q L EN LR +L++ E +L+ EL +LR +
Sbjct: 278 ENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRAR 337
Query: 335 IRILED---KGTSTELV------KENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRE 385
++ LE +G + + ++ +++ E++ + SFL Q+E L EA+ L++E
Sbjct: 338 LQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQE 397
Query: 386 LERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRS 445
LER+R L G +QQ L S + L EL +L + Q
Sbjct: 398 LERQR----RLLGSVQQDLERSLQDASRGDPAHAG----------LAELGHRLAQKLQGL 443
Query: 446 DLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVR 505
+ W Q+ + K + SH ++ ++ +D ++ E +
Sbjct: 444 ENW--------GQDPGVSANASKAWHQKSHFQNSRE----WSGKEKWWDGQRDRKAEHWK 491
Query: 506 HHKEKIKQAKEAVKENLKKFSDSV-KSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRT 564
H KE E+ +E K + + +K+ + +E G+K+ G + E PR
Sbjct: 492 HKKE------ESGRERKKNWGGQEDREPAGRWKEGRPRV-EESGSKKEGKRQGPKEPPR- 543
Query: 565 VFSDYLHPQYKAPTENHHNRGPTMQNDGRKEKPVHFKEFRKNTNSKKCSPGHDCRENSHS 624
+ + + G K+K ++E K+++ S R +
Sbjct: 544 -------------------KSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRA 584
Query: 625 FRKACSGVFDCAQQESMSLFNTVVNPIRMDEFRQIIQRYMLKELDTFCHWNELDQFINKF 684
+ CSGV +CA+QE ++ F T + P+R E +++ Y+ + EL F
Sbjct: 585 -PQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFF 643
Query: 685 FLNGVFIHDQKLFTDFVNDVKDYLRNMKEYEVDNDGVFEKLDEYIYRHFFG 735
+G+F HD+ F DFV+ ++D L + + +D + +++I+ HFFG
Sbjct: 644 GEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFG 694
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.8 bits (164), Expect = 4e-11
Identities = 118/527 (22%), Positives = 217/527 (41%), Gaps = 83/527 (15%)
Query: 53 LQIEQGESSQNGTVLME-ETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEP 111
LQ +Q SQ + L E + Y +LE+ + +E + +K+ DS+ + + + +
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA------- 749
Query: 112 PKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQP 171
L+++ Q Q + D + ++ S+ + E V SS D + S+ +
Sbjct: 750 --LQDLQQQR-------QLNTDLELRATELSKQLEMEKEIV-SSTRLDLQKKSEALESI- 798
Query: 172 SPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGF 231
K + E++ + +Q+ E + +K Q N+
Sbjct: 799 -----------KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR-------------- 833
Query: 232 GHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQE-QESFIDYKSLKENLARCWTLTE 290
T+ ++ ++ ++ EL+ +KD LS+ + S +++ KEN + +
Sbjct: 834 --IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE--KENQKGKAAILD 889
Query: 291 AEKM------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTS 344
EK + Q N E + L+ SLEKE++A L+ ELN ++EQ +++ + T
Sbjct: 890 LEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ--LIQAQNTL 947
Query: 345 TELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAK---MLKRELE---RERLVTTA--L 396
+ KE Q+L+ ++ E KQ Q E L E K + K ELE +++L A L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 397 RGELQQLS-------GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQ-----R 444
E +++S SQ K + Y + E+ R+ L +E KL+ Q+ R
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 445 SDL--WERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKE 502
+ + +L E K D KK + R K S+KE + N +
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE--KELVNEKSK 1125
Query: 503 FVRHHKEKIKQAKEAVKENLKKFSDSVKS--TFRHFKDTTKNIFDEK 547
+ K +Q KE K N + S ++S + KD + + +K
Sbjct: 1126 LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Score = 44.7 bits (104), Expect = 3e-04
Identities = 118/569 (20%), Positives = 216/569 (37%), Gaps = 77/569 (13%)
Query: 37 EPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPALE---------ETSSTIEAEE 87
+ + E SLEQ+ L+ Q E Q + ++ A A E E S EA E
Sbjct: 132 DSSAELQSLEQQ-LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE 190
Query: 88 QKIP---EDSIYIGTASDDSDIVTLEPPKLEEIG--NQEVVIVEEAQSSEDFNMGSSSSS 142
QK+ E+ T D L+ P +E++ +E+V V+ + S
Sbjct: 191 QKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250
Query: 143 QYTFCQP-ETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETE 201
C+ ++ ++S + E + P + +K S S + L + +T
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS---SVNELTQKNQTL 307
Query: 202 PSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDY 261
L K Q + L + H ++ ++ + +H+ +L+ +
Sbjct: 308 TENLLKKEQDYTKLEE--------------KHNEESVS---KKNIQATLHQKDLDCQQLQ 350
Query: 262 LSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKAL 321
E + L E L E E ET+ +L E + L+ E++E+
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKE-ELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
Query: 322 SSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKM 381
LQ E+N+L ++LE T +L + + +LK+ + +K Q L +
Sbjct: 410 LQLQSEINQLHS--KLLE---TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 382 LKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELE---RKL 438
L+ +L+ + +T L+ +L + Q H + + ++ A LRE +LE R++
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKT--KQQHQEQQA----LQQSTTAKLREAQNDLEQVLRQI 518
Query: 439 TFEQQRSDLWERLYVEAKD-----QNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETF 493
+ Q+ E L ++K+ + ++ K + G G N+ +E
Sbjct: 519 GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQE---------- 568
Query: 494 DAMKNST-KEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNI--FDEKGNK 550
KN T +E V EK+K E+ K+ + D V+ H + + + N+
Sbjct: 569 ---KNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 551 RFGATKEAAEKPRTVFSDYLHPQYKAPTE 579
E+ EK L Q KA TE
Sbjct: 626 LNSQLNESKEK-----VSQLDIQIKAKTE 649
Score = 38.9 bits (89), Expect = 0.018
Identities = 82/398 (20%), Positives = 168/398 (42%), Gaps = 44/398 (11%)
Query: 46 EQEELQ-ALQIEQGESSQNGTVL--MEETAYPALEETSSTIEAEEQKIPEDSIYIGTASD 102
EQ+EL+ +L+ E+ S Q L M+E A + T E EEQ++ + + +S+
Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQA-QNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 103 DSDIVTLEPPKLEEI-GNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDE 161
+ ++E + G ++ ++++ + + ++Q + E + Q ++
Sbjct: 970 Q------KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ--NNY 1021
Query: 162 SSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVIL 221
S ET Q F R+ + A+ + + V E+ + ++L + G +I
Sbjct: 1022 EKSQETFKQLQSDFY---GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 222 ALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKEN 281
L T + Q +K E +L + L Q+E KSLKE
Sbjct: 1079 ELK------------TAKATLEQDSAKK--EQQLQERCKALQDIQKE-------KSLKEK 1117
Query: 282 --LARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILE 339
+ L E E++ +K + N+ L+ + K +++L++ L +Q L+
Sbjct: 1118 ELVNEKSKLAEIEEIKCRQEK-EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176
Query: 340 DKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGE 399
K S + E +K Q + +++ KK ++E + EAK+ E+E ++
Sbjct: 1177 GKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE----VGMKKH 1232
Query: 400 LQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERK 437
+ + + + + N+ T KKE + R++ELE++
Sbjct: 1233 EENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270
Score = 38.1 bits (87), Expect = 0.030
Identities = 71/350 (20%), Positives = 139/350 (39%), Gaps = 55/350 (15%)
Query: 243 RQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTN 302
+Q K+ E + ND++ L Q + + + ++L + +L E E+
Sbjct: 497 QQSTTAKLREAQ-NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER--------- 546
Query: 303 LATENQYLRVSL-EKEEKALSSLQEELNKLREQIRILEDK----GTSTELVKEN-----Q 352
E+ Y ++ E E L+ LQE+ + L+EQ+ L +K S + +EN Q
Sbjct: 547 ---EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 353 KLKQHLEEEKQKKHSF---LSQRETLLTEAKMLKRELE-----RERLVTTALRGELQQLS 404
+ K HL + + S +++ + L E+K +L+ + L+ +A + Q +
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKD-----QN 459
Q H + + +++E+ + +L ++ KL +Q+ E E K+ +
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723
Query: 460 GKQGTDGKKKGGRGSHRAKNKSKETFLGSVKE-------------TFDAMKNSTKEFV-- 504
+ +G+ K SKE L +++ KE V
Sbjct: 724 KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS 783
Query: 505 -RHHKEKIKQAKEAVKENLKKFSDS---VKSTFRHFKDTTKNIFDEKGNK 550
R +K +A E++K+ L K + +K F TK +E N+
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 67.0 bits (162), Expect = 6e-11
Identities = 97/431 (22%), Positives = 175/431 (40%), Gaps = 64/431 (14%)
Query: 148 QPETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELS 207
+ E ++ D E + +E + + RR+ +K VS + ++ L + ++E +
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEA---RRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 208 KRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ 267
+ GL K IL ++ + ++ R E+E+N + +++ +
Sbjct: 905 AEERCEGLIKSKIL----------------LEAKVKELTERLEEEEEMNS--ELVAKKRN 946
Query: 268 EQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEE 327
++ K ++L T E EK + E + NL+ E L ++ K K SLQE
Sbjct: 947 LEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEA 1006
Query: 328 LNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELE 387
+ + +++ EDK L+K N KL+Q ++ L Q + L + + KR+LE
Sbjct: 1007 HQQTLDDLQVEEDKVNG--LIKINAKLEQQTDD----LEGSLEQEKKLRADLERAKRKLE 1060
Query: 388 RERLVTTA----LRGELQQLSG---------SQLHGKSDSPNVYT--EKKEIAILRERLT 432
+ ++ L + QQ+ SQL K D V++ +K+I L+ R+
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 433 ELERKL--------TFEQQRSDLWERL------YVEAKDQNGKQGTDGKK------KGGR 472
ELE ++ E+QRSDL L EA Q KK K R
Sbjct: 1121 ELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRR 1180
Query: 473 GSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKST 532
A + + T K+ D++ ++ + +++KQ E K LK D + S
Sbjct: 1181 DLEEATLQHEATAATLRKKQADSVAELGEQI--DNLQRVKQKLEKEKSELKMEIDDMASN 1238
Query: 533 FRHFKDTTKNI 543
+ NI
Sbjct: 1239 IEALSKSKSNI 1249
Score = 48.5 bits (114), Expect = 2e-05
Identities = 61/334 (18%), Positives = 133/334 (39%), Gaps = 42/334 (12%)
Query: 244 QQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNL 303
Q++ R + E L + +++ +S + +NL R E EK + + ++
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 304 ATENQYLRVSLEKEEKALSSLQEELNKLR----EQIRILEDKGTS-TELVKENQKLKQHL 358
A+ + L S E+ +++++ ++++ +Q +++ D L +N +L +
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 359 EEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVY 418
EE++ ++ L + + LKR++E E A+ LQ S H Y
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ----SSRHDCDLLREQY 1351
Query: 419 TEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAK 478
E++E EL+R L+ W Y Q ++ + KKK + A+
Sbjct: 1352 EEEQEAK------AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405
Query: 479 -------------NKSKETFLGSVKE-------------TFDAMKNSTKEFVRHHKEKIK 512
K+K+ G V++ T D + + + + K+K+
Sbjct: 1406 ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLD 1465
Query: 513 QAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDE 546
++ +A E +K S S+ + ++ + + D+
Sbjct: 1466 ES-QAELEAAQKESRSLSTELFKMRNAYEEVVDQ 1498
Score = 39.3 bits (90), Expect = 0.014
Identities = 35/151 (23%), Positives = 77/151 (50%), Gaps = 3/151 (1%)
Query: 240 IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++K +Q ++ ED + D++ + C + ++ + + ++AE + + +
Sbjct: 1418 LEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTST-ELVKENQKLKQHL 358
+L+TE +R + E+ L +L+ E L+E+I L ++ T + ++E +K K+ +
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLV 1537
Query: 359 EEEKQKKHSFLSQRETLL--TEAKMLKRELE 387
E+EK L + E L E+K+L+ +LE
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLE 1568
Score = 38.1 bits (87), Expect = 0.030
Identities = 83/459 (18%), Positives = 167/459 (36%), Gaps = 115/459 (25%)
Query: 75 ALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPK-LEEIGNQEVVIVEEAQSSED 133
ALEE ++E EE KI + + + D +E + +E++ E QS D
Sbjct: 1547 ALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLD 1606
Query: 134 FNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASES--E 191
+ S + + + + ++ E ++ Q + + R + + S+ +
Sbjct: 1607 AEIRSRNDA----LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLD 1662
Query: 192 DRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIH 251
D L + ++ + + +R+ +GL + + +A+ ++ + R++
Sbjct: 1663 DALRSNEDLKEQLAIVERR--NGLLLEELEEMKVAL--------------EQTERTRRLS 1706
Query: 252 EDELNDMKDYLSQCQQEQESFIDYKS-LKENLARCWTLTEAEKMSFETQKTNLATENQYL 310
E EL D D + + S I+ K L+ ++A+C E
Sbjct: 1707 EQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE-------------------- 1746
Query: 311 RVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLS 370
+S+QE N + + + D E +K+ Q HLE K+ +
Sbjct: 1747 -----------NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 371 QRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRER 430
+ L EA+ L AL+G KK+I L R
Sbjct: 1796 DLQHRLDEAEQL------------ALKG---------------------GKKQIQKLENR 1822
Query: 431 LTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVK 490
+ ELE +L EQ K+G + K G+H+ + K KE + +
Sbjct: 1823 VRELENELDVEQ------------------KRGAEALK----GAHKYERKVKEMTYQAEE 1860
Query: 491 ETFDAMK-----NSTKEFVRHHKEKIKQAKEAVKENLKK 524
+ + ++ + + V+ +K + ++A+E L +
Sbjct: 1861 DHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSR 1899
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 66.2 bits (160), Expect = 1e-10
Identities = 103/495 (20%), Positives = 206/495 (41%), Gaps = 54/495 (10%)
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATE 306
+R+ H+ E+ ++++ LSQ +E+E+ + + K+ + + L ET KT + E
Sbjct: 2402 LRQQHDKEIKELENLLSQ--EEEENIVLEEENKKAVDKTNQL-------METLKT-IKKE 2451
Query: 307 NQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVK---------ENQKLKQH 357
N + L+ K++SSLQ + +++ + LE++ S L K EN KLK+
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 358 LEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNV 417
+ + S+ L E + +L + V T + +QL QL + N
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQ---VITIKDSQQKQLLEVQLQQNKELENK 2568
Query: 418 YTEKKEIAILRERLTELERKL--TFEQQRSDLWERL--YVEAKDQNGKQGTDGKKKGGRG 473
Y + +E E E R+ ++++ DL + + + Q +Q T +++G G
Sbjct: 2569 YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLG 2628
Query: 474 SHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTF 533
+ A+ K KE + + F +S K +E + KEA K+ + + D +K
Sbjct: 2629 LYHAQLKVKEEEVHRLSALF---SSSQKRIAELEEELVCVQKEAAKK-VGEIEDKLKKEL 2684
Query: 534 RHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENHHNRGPTMQNDGR 593
+H + + G R T+ A E+ + D + + K N+G T Q
Sbjct: 2685 KH-------LHHDAGIMR-NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQ---- 2732
Query: 594 KEKPVHFKEFRKNTNSKKCSPGHDCRENSHSFRKACSGVFDCAQQESMSLFNTVVNPIRM 653
+ F ++ +S + S H E RK + + + AQ + L N + +
Sbjct: 2733 ------IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLS 2786
Query: 654 DEFRQIIQRYMLKELDTFCHWNELDQFINKFFLNGVFIHDQKLFTDFVNDVKDYLRNMKE 713
+ + E ++ H +L+Q + + +H D N V+ + + M
Sbjct: 2787 ETAFSMNS----TEENSLSHLEKLNQQL--LSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840
Query: 714 YEVDNDGVFEKLDEY 728
+ + D ++ +L+++
Sbjct: 2841 LQNERDHLWNELEKF 2855
Score = 54.3 bits (129), Expect = 4e-07
Identities = 77/316 (24%), Positives = 137/316 (43%), Gaps = 30/316 (9%)
Query: 240 IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
IQ +++ +R + ED + +KD L Q E S E+ + W ++ + +
Sbjct: 2219 IQSKEEEIR-LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK 2277
Query: 300 KTN-LATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHL 358
+ L EN+ L LE+ S Q EL KL +++ L+D+ T+L +K K
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ--LTDLSNSLEKCK--- 2332
Query: 359 EEEKQKKHSFLSQRETLLTEAK----MLKRELERERLVTTALRGEL---QQLSGSQLHGK 411
E+K + Q+E + +K L+ +L+ R +T+ L E+ +Q S L GK
Sbjct: 2333 -EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391
Query: 412 SDSPNVYTEKKEIAILRER----LTELERKLTFEQQRSDLWERLYVEAKDQ-NGKQGTDG 466
++ V IA LR++ + ELE L+ E++ + + E +A D+ N T
Sbjct: 2392 EEAIQV-----AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLK 2446
Query: 467 KKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHH----KEKIKQAKEAVKENL 522
K +A+ S + S++ D + ++ H EK + +EA EN
Sbjct: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAEN- 2505
Query: 523 KKFSDSVKSTFRHFKD 538
K + ++ H D
Sbjct: 2506 NKLKEEIRGLRSHMDD 2521
Score = 50.4 bits (119), Expect = 6e-06
Identities = 53/208 (25%), Positives = 93/208 (44%), Gaps = 38/208 (18%)
Query: 323 SLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
S +E+N +QI L+++ E +E QK K+ + + +K++ LSQ T E KML
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAGLE--EEKQKNKEFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E+ + L+ ++ EL R+T+L K T E+
Sbjct: 1888 QEEVTKMNLLNQQIQEEL----------------------------SRVTKL--KETAEE 1917
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKE 502
++ DL ERL + + NG G + + KN+ E+ + ++K+ ++ ++
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYCQDV---TDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 503 FVRHHKEKIKQAKEAVKENLKKFSDSVK 530
V KEK K E KE L+K + K
Sbjct: 1975 LV---KEKTKVESEIRKEYLEKIQGAQK 1999
Score = 48.9 bits (115), Expect = 2e-05
Identities = 77/343 (22%), Positives = 145/343 (42%), Gaps = 43/343 (12%)
Query: 237 TIQIQKRQQLVRKIHED------ELNDMKDYLSQCQQEQESFID-YKSLKENLARCWTLT 289
T ++ K+ + V ++ E E+ +K + + ES +S + +A L
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR 1388
Query: 290 EAEKMSFETQKTNLATENQ--YLRVSLEKEEKALSSLQEELNKLREQIRILED------- 340
E + E QK E YL L ++E AL+ +Q E+ + + I+ L
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK 1448
Query: 341 ------KGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTT 394
K EL + QK ++ EE + K+ + L++ + LK + ++
Sbjct: 1449 EHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSL 1508
Query: 395 ALRGELQQLSGSQLHGKSDSPNVYTEKKEI----AILRER----LTELERKLTFEQQRSD 446
A RG +++L+ S +S EK + A+L+E +TE++R L Q S
Sbjct: 1509 A-RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSS 1567
Query: 447 LWERLYV------EAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNST 500
E L + E K++ K+ K S + K KE +++ ++ + S
Sbjct: 1568 SCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE-----LQKEYEILLQSY 1622
Query: 501 KEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNI 543
E V + E+I+ EAV++ ++ ++ST + K+T K +
Sbjct: 1623 -ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQL 1664
Score = 46.6 bits (109), Expect = 9e-05
Identities = 73/317 (23%), Positives = 130/317 (41%), Gaps = 29/317 (9%)
Query: 240 IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSF--- 296
IQ R+ L + I + + Q QQ +E Y L+E L E + SF
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 297 ETQKTNLATENQYLRVSLEKEEKALSSLQEE--LNKLREQIRILEDK-GTSTELVKENQK 353
+ +K +L+ E + L+VS+ + + +++LQEE L Q+++ E++ + L +QK
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
Query: 354 LKQHLEEE-----KQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQL 408
LEEE K+ + L E K L + R T + +L+ +
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLV 2713
Query: 409 HGKSDSPNVYTEKK----EIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
+ V E K +I ++ L+ + D +R Y D + K+
Sbjct: 2714 EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKY----DASLKELA 2769
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKK 524
K++G N+ ++ L ET +M NST+E H EK+ Q + E L
Sbjct: 2770 QLKEQG------LLNRERDALLS---ETAFSM-NSTEENSLSHLEKLNQQLLSKDEQLLH 2819
Query: 525 FSDSVKSTFRHFKDTTK 541
S ++ ++ + +K
Sbjct: 2820 LSSQLEDSYNQVQSFSK 2836
Score = 43.5 bits (101), Expect = 7e-04
Identities = 63/278 (22%), Positives = 122/278 (43%), Gaps = 45/278 (16%)
Query: 240 IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWT---LTEAEKMSF 296
+ +QQL K E+ ++ ++ LSQ Q EQ + + ++E AR T L E E +
Sbjct: 186 VMMKQQLQEK--EEFISTLQAQLSQTQAEQAA---QQVVREKDARFETQVRLHEDELLQL 240
Query: 297 ETQ---KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQK 353
TQ +T + + + L+ LE+ E++L + ++ L++++ E + NQ
Sbjct: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQR---------NQI 291
Query: 354 LKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERE----RLVTTALRGELQQL-----S 404
L Q L++ + + ++ + ET E+K+L ++E E +L L+ E+ L
Sbjct: 292 LSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQ 351
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
Q + +S E+K A + E+ + + Q+ + L KDQN K
Sbjct: 352 AGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL----KDQNSKLLQ 407
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKE 502
D KN+ ++++ D ++ +KE
Sbjct: 408 D------------KNEQAVQSAQTIQQLEDQLQQKSKE 433
Score = 43.5 bits (101), Expect = 7e-04
Identities = 75/334 (22%), Positives = 139/334 (41%), Gaps = 63/334 (18%)
Query: 253 DELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRV 312
DE+N+ YL Q Q LKE +A E EK + L E L
Sbjct: 1833 DEINN---YLQQIDQ----------LKERIAGL----EEEKQKNKEFSQTLENEKNTLLS 1875
Query: 313 SLEKEEKALSSLQEE---LNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFL 369
+ ++ L LQEE +N L +QI+ E+ T+L + ++ K LEE + + L
Sbjct: 1876 QISTKDGELKMLQEEVTKMNLLNQQIQ--EELSRVTKLKETAEEEKDDLEERLMNQLAEL 1933
Query: 370 S---------------QRETLLTEAKMLKR-----ELERERLV--TTALRGELQQLSGSQ 407
+ + E L +E K LK+ E E+++LV T + E+++ +
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
Query: 408 LHGKSDSPNVYTEKKEIAIL----RERLTELERKLTFEQQRSDLWERL-----YVEAKDQ 458
+ G P + KE+ L ++ + +L++ Q++ ER +V+ + Q
Sbjct: 1994 IQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQ 2053
Query: 459 NGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHH---KEKIKQAK 515
+ T + HR K +++ L S K D ++ + + K++++ K
Sbjct: 2054 KDLEITK-ENLAQAVEHRKKAQAE---LASFKVLLDDTQSEAARVLADNLKLKKELQSNK 2109
Query: 516 EAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGN 549
E+VK +K+ + ++ R + + EK N
Sbjct: 2110 ESVKSQMKQKDEDLE---RRLEQAEEKHLKEKKN 2140
Score = 39.7 bits (91), Expect = 0.010
Identities = 113/569 (19%), Positives = 205/569 (36%), Gaps = 75/569 (13%)
Query: 17 ISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPAL 76
I+ +G +IE L +V+ LE +LQ +E Q P L
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ-----------PKL 1394
Query: 77 EETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLE-EIGNQEVVIVEEAQSSEDFN 135
+E I +E+ + S G S+ +T K++ EI QE +I +A ++
Sbjct: 1395 DELQKLISKKEEDV---SYLSGQLSEKEAALT----KIQTEIIEQEDLI--KALHTQLEM 1445
Query: 136 MGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQ-----PSPAFRRRRARKKTVSASE- 189
+ Q E Q ++ Q + R+ A K+ S E
Sbjct: 1446 QAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEE 1505
Query: 190 -SEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVR 248
S R E+ T+ ++ + + K +L + + I R L
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKL---ITEMDRSLLEN 1562
Query: 249 KIHEDELNDMKDYLSQCQQEQESFI-DYKSLKENLARCWTLTEAEKMSFETQKTNLATEN 307
+ +K L +++E + + +SLK + + TE ++ E QK
Sbjct: 1563 QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSS--KIAESTEWQEKHKELQKEYEILLQ 1620
Query: 308 QYLRVSLEKE--EKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKK 365
Y VS E E + + ++++E +L ++R E TE K+ Q+ +Q +EE K+K
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE--KQLQEAEQEMEEMKEKM 1678
Query: 366 HSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTE----- 420
F + + K+L+ E E +RL +++H D+ E
Sbjct: 1679 RKFAKSK-----QQKILELEEENDRL-------------RAEVHPAGDTAKECMETLLSS 1720
Query: 421 ----KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHR 476
K+E+ ++ L +K D + K Q +G K+ + +
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ--IEGNVSKQANLEATEK 1778
Query: 477 AKNKSKETFLGSVK-----ETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSD--SV 529
N++ T G+ E D++ ST+ K A AV ++ + +
Sbjct: 1779 HDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY 1838
Query: 530 KSTFRHFKDTTKNIFDEK-GNKRFGATKE 557
K+ + +EK NK F T E
Sbjct: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTLE 1867
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/150 (24%), Positives = 69/150 (46%), Gaps = 5/150 (3%)
Query: 244 QQLVRKIHEDELNDMKDYLSQCQQEQESFID-YKSLKENLARCWTLTEAEKMSFETQKTN 302
QQL+ K +++L + L + +SF SL+ W E + S E K
Sbjct: 2808 QQLLSK--DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS-EEGKQR 2864
Query: 303 LATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTS-TELVKENQKLKQHLEEE 361
A + ++ +KA+SSLQ + ++L ++++ L+ + + + E LK L+E
Sbjct: 2865 SAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEY 2924
Query: 362 KQKKHSFLSQRETLLTEAKMLKRELERERL 391
+ K +F +E L E + EL + R+
Sbjct: 2925 QDKTKAFQIMQEELRQENLSWQHELHQLRM 2954
Score = 37.4 bits (85), Expect = 0.052
Identities = 69/326 (21%), Positives = 133/326 (40%), Gaps = 30/326 (9%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
+++QQLV++ + E K+YL + Q Q+ + KE L E ++ + QK
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE---LLKEKQQEVKQLQK 2026
Query: 301 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEE 360
+ + + +LE+ KAL +Q E K E+ KEN L Q +E
Sbjct: 2027 DCIRYQEKI--SALERTVKALEFVQTESQK-------------DLEITKEN--LAQAVEH 2069
Query: 361 EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQ---QLSGSQLHGKSDSPNV 417
K K + L+ + LL + + E R L+ ELQ + SQ+ K +
Sbjct: 2070 RK-KAQAELASFKVLLDDT---QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLER 2125
Query: 418 YTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRA 477
E+ E L+E+ E+ +++ L E + N K + + S
Sbjct: 2126 RLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185
Query: 478 KNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVK---ENLKKFSDSVKSTFR 534
+ + + S+++ D + + K++ R + I+ +E ++ +N D ++
Sbjct: 2186 QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI 2245
Query: 535 HFKDTTKNIFDEKGNKRFGATKEAAE 560
H ++ NI + +K+ +K E
Sbjct: 2246 HMEELKINISRLEHDKQIWESKAQTE 2271
Score = 37.0 bits (84), Expect = 0.068
Identities = 45/235 (19%), Positives = 95/235 (40%), Gaps = 23/235 (9%)
Query: 299 QKTNLAT-ENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQH 357
QK + T EN+ L ++ +++SSLQ + E++ L+ K ++ +KE +LK+
Sbjct: 2717 QKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS--LKELAQLKE- 2773
Query: 358 LEEEKQKKHSFLSQRETLLTEAKMLKRELERERLV-TTALRGELQQLSGSQLHGKSDSPN 416
+ +R+ LL+E E L L +L LH S +
Sbjct: 2774 -------QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826
Query: 417 VYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHR 476
Y + + + + + + +R LW L K + GKQ + + +
Sbjct: 2827 SYNQVQSFS---------KAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQ 2877
Query: 477 AKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKS 531
+ K+ + +KN +++++ ++E + +K L+++ D K+
Sbjct: 2878 SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE--LHPLKAQLQEYQDKTKA 2930
Score = 36.6 bits (83), Expect = 0.089
Identities = 66/328 (20%), Positives = 139/328 (42%), Gaps = 52/328 (15%)
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATE 306
+ + H+DEL +K + + L+ N + + E + +NL
Sbjct: 678 IGQCHQDELERLKSQILE-------------LELNFHKAQEIYEKNLDEKAKEISNLNQL 724
Query: 307 NQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHL-EEEKQKK 365
+ + + + A ++L EE ++L Q++ L TEL + ++L+ +L E E+Q++
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKEL---SMVTELRAQVKQLEMNLAEAERQRR 781
Query: 366 HSFLSQ--RETLLTE---------------AKMLKRELERERL-------VTTALRGELQ 401
+ SQ + LLTE ++L+ EL+ +L + +L+ +LQ
Sbjct: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ 841
Query: 402 QLSGSQLHGKSDSPNVYTEKKEIA-ILRERLTELER--KLTFEQQRSDLWERLYVEAKDQ 458
L G ++ ++ +E++ L ++ E+ + +L E++R + +E KDQ
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 459 NGKQGTDGKKKGGRGSHRAKNKSKETF-LGSVKETFDAMKNSTKEFVRHHKEKIKQAKEA 517
+ + + + ++E F LG +T N KE++++ E
Sbjct: 902 QVTEISFSM------TEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE- 954
Query: 518 VKENLKKFSDSVKSTFRHFKDTTKNIFD 545
V LK+ D + + K+ ++ FD
Sbjct: 955 VSSGLKQNYDEMSPAGQISKEELQHEFD 982
Score = 36.6 bits (83), Expect = 0.089
Identities = 117/621 (18%), Positives = 239/621 (38%), Gaps = 76/621 (12%)
Query: 3 ENSSDSDSSCGWTVISHEG----SDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQG 58
+ ++D++SS +T +S E S ++ L+ VT + E + E E + L E
Sbjct: 729 KKNADNNSSA-FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQ 787
Query: 59 ESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIG 118
+ N +L E+ ++E S ++ E + D + + + + I +L+ ++
Sbjct: 788 TAHDN--LLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ----SQLQ 841
Query: 119 NQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRR 178
N+E ++E A+ + SQ Q E E + ++
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQ-ALSQKEL--------------EITKMDQLLLEKK 886
Query: 179 RARKKTVSASESEDRLVAE---QETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFY 235
R + E +D+ V E TE +L++ +FS G+ + + +S
Sbjct: 887 RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS------- 939
Query: 236 GTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMS 295
R + +K +E N++ L Q E KE L + L + E
Sbjct: 940 -------RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS--KEELQHEFDLLKKENEQ 990
Query: 296 FETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ + + L + + E+ L++L++E K +I + E + E KEN++
Sbjct: 991 RKRKLQAALINRKELLQRVSRLEEELANLKDESKK---EIPLSETERGEVEEDKENKEYS 1047
Query: 356 QHLEEEK-QKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDS 414
+ K Q+ +L Q ++E ++ + + ++ A + Q L D
Sbjct: 1048 EKCVTSKCQEIEIYLKQT---ISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDK 1104
Query: 415 PNVYTEKKEIAILRERLTE----LERKLTFEQQRSD-----LWERLYVEAKDQNGKQGTD 465
N +I +L+ ++E +++ +T SD L + V + G ++
Sbjct: 1105 TN------QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGS--SE 1156
Query: 466 GKKKGGRGSHRAKNKSKETFLGSVKETFDAMK---NSTKEFVRHHKEKIKQAKEAVKENL 522
K A K KE ++E + K +E RH +E++KQ K+
Sbjct: 1157 HWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ 1216
Query: 523 KKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVFSDYL-HPQYKAPTENH 581
++F + K + D + + + G ++ + L P +KA TE H
Sbjct: 1217 EQFDEQSKEN-ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKA-TEQH 1274
Query: 582 HNRGPTMQNDGRKEKPVHFKE 602
H + P ++++ + P H ++
Sbjct: 1275 HTQ-PVLESNLCPDWPSHSED 1294
Score = 32.3 bits (72), Expect = 1.7
Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 32/239 (13%)
Query: 290 EAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVK 349
EAEK+ E + ++ +E L K+ + + LQE++NK +I L K S E
Sbjct: 1315 EAEKVELELKVSSTTSE-------LTKKSEEVFQLQEQINKQGLEIESL--KTVSHEAEV 1365
Query: 350 ENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLH 409
+ L+Q LE + + RE L+ +L+ + + + ++ LSG
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRE--------LQPKLDELQKLISKKEEDVSYLSGQLSE 1417
Query: 410 GKSDSPNVYTEKKEIAILRERL-TELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKK 468
++ + TE E L + L T+LE + +R ++L VE + K G++
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERI---KQLQVELCEMKQKPEEIGEE 1474
Query: 469 KGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSD 527
RAK + + ++ +A+K + + +E++ A+ ++ K +D
Sbjct: 1475 S------RAKQQIQRKLQAALISRKEALKEN-----KSLQEELSLARGTIERLTKSLAD 1522
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 60.1 bits (144), Expect = 7e-09
Identities = 126/554 (22%), Positives = 214/554 (38%), Gaps = 99/554 (17%)
Query: 30 VTPTDSCEPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPAL---EETSSTIEAE 86
+ T S + + L+++ + +N + L+ L E ++ IEA+
Sbjct: 7 IASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQ 66
Query: 87 EQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTF 146
E IP+ G D E+I N ++ + + + + T
Sbjct: 67 ENYIPDH----GGGEDSCAKTDTGSENSEQIAN-----FPSGNFAKHISKTNETEQKVTQ 117
Query: 147 CQPETVFSSQPSDDESSSDET-SNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKE 205
E S+ P ES++++T S P ++ K S S SED L + S E
Sbjct: 118 ILVELRSSTFP---ESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTE 174
Query: 206 LSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQC 265
++ + +G+NK G + ++ V+ + + + +K + +
Sbjct: 175 FAEHRVPNGMNK------------------GEHALVLFEKCVQDKYLQQEHIIKKLIKEN 216
Query: 266 QQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQ 325
++ QE F+D S K+NL E K ET+K ++ T Q L S
Sbjct: 217 KKHQELFVDICSEKDNLR------EELKKRTETEKQHMNTIKQ------------LESRI 258
Query: 326 EELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRE 385
EELNK E K + +L+ ++ K +++ ++ + Q EA+
Sbjct: 259 EELNK--------EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQ---- 306
Query: 386 LERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRS 445
E+E +V +RGE + L L + ++ EKK LR+ ELE+ +Q S
Sbjct: 307 -EKEAMVMKYVRGEKESLD---LRKEKET----LEKK----LRDANKELEKNTNKIKQLS 354
Query: 446 DLWERLYVEAKDQNGKQGT----DGKKKGGRGSHR-----AKNKSKETFLGSVKETFDAM 496
RL+ + + G+ K K SH A+NK K + S KET D +
Sbjct: 355 QEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAE-MDSHKETKDKL 413
Query: 497 KNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATK 556
K +T K+ QAKE + K D +K T++ ++ N D K TK
Sbjct: 414 KETTT--------KLTQAKEEADQIRKNCQDMIK-TYQESEEIKSNELDAK----LRVTK 460
Query: 557 EAAEKPRTVFSDYL 570
EK SD L
Sbjct: 461 GELEKQMQEKSDQL 474
Score = 33.1 bits (74), Expect = 0.98
Identities = 42/183 (22%), Positives = 77/183 (42%), Gaps = 18/183 (9%)
Query: 314 LEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQ---KL---KQHLEEEKQKKHS 367
L++ L+ +EE +++R+ + + +E +K N+ KL K LE++ Q+K
Sbjct: 413 LKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSD 472
Query: 368 FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAIL 427
L + E + LKR + LR +++ L +L D + Y E I+
Sbjct: 473 QLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLR-TEDELSKYKE-----II 526
Query: 428 RERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLG 487
+ E++ L + L E+L Q GKQ + K+ + N ++ G
Sbjct: 527 NRQKAEIQNLLDKVKTADQLQEQL------QRGKQEIENLKEEVESLNSLINDLQKDIEG 580
Query: 488 SVK 490
S K
Sbjct: 581 SRK 583
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 58.9 bits (141), Expect = 2e-08
Identities = 51/240 (21%), Positives = 108/240 (45%), Gaps = 35/240 (14%)
Query: 240 IQKRQQLVRKIHE--DELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTL----TEAEK 293
+Q+++++ ++H+ E++ + ++ ++E + +D + N A W + E E
Sbjct: 845 VQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGES 904
Query: 294 MSFETQKTNLATENQYLRVS---LEKE-----------EKALSSLQEELNKLREQIRILE 339
S + ++ TE ++LR LEKE E +SS+ + +++L E++R E
Sbjct: 905 SSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQE 964
Query: 340 DKGTST------------ELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELE 387
D+ + +L + Q L + + + + E + +E+ +LK++L
Sbjct: 965 DEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSKNLEFERVVVELENVKSESDLLKKQLS 1024
Query: 388 RERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDL 447
ER L L + H S + + EI +L+E+LT E KLT + + + +
Sbjct: 1025 NERHTVKNLESLLATNRDKEFHSHLTS---HEKDTEIQLLKEKLTLSESKLTSQSRENTM 1081
Score = 39.7 bits (91), Expect = 0.010
Identities = 77/326 (23%), Positives = 132/326 (40%), Gaps = 69/326 (21%)
Query: 259 KDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEE 318
KD+L + E+ I +L+ENLA K+ ++++ NQ L+ +L +
Sbjct: 736 KDFLQETVDEKTEKI--ANLQENLANKEKAVAQMKIMISECESSV---NQ-LKETLVNRD 789
Query: 319 KALSSLQEELNKLREQIRILEDKGTSTELV---------------KENQKLKQHLEEEKQ 363
+ ++SL+ +L+ ++ L++ G S E+ +ENQ++ LE Q
Sbjct: 790 REINSLRRQLDAAHKE---LDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQ 846
Query: 364 KKHSFLSQRETLLTEAK-----MLKRELERERLVTTAL----RGELQQLSGSQLHGKSDS 414
+K S+ +TE M +E E + L+ R E ++ Q G+S S
Sbjct: 847 EKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSS 906
Query: 415 P-----NVYTEKKEIAILRERLTELERKL--------TFEQQRSDL---WERLYVEAKDQ 458
++ TE++ LRER+ LE+++ +E Q S + RL E + Q
Sbjct: 907 VRLELLSIDTERRH---LRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQ 963
Query: 459 NGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK-EFVRHHKEKIKQAKEA 517
++ T K L S K+ NS EF R E
Sbjct: 964 EDEKATVLNDLSSLRELCIK-------LDSGKDIMTQQLNSKNLEFERVVVE-------- 1008
Query: 518 VKENLKKFSDSVKSTFRHFKDTTKNI 543
EN+K SD +K + + T KN+
Sbjct: 1009 -LENVKSESDLLKKQLSNERHTVKNL 1033
Score = 32.0 bits (71), Expect = 2.2
Identities = 34/147 (23%), Positives = 63/147 (42%), Gaps = 8/147 (5%)
Query: 297 ETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQ 356
+T+ +L N+ L+ S++ + LS + EL + QI+ILE+K L +Q +
Sbjct: 663 KTEVNSLRIVNEQLQRSVDDYQHRLSIKRGELESAQAQIKILEEKIDELNLKMTSQDEEA 722
Query: 357 HLEEEK----QKKHSFLSQRETLLTE-AKMLKRELERERLVTTALRGELQQLSGSQLHGK 411
H+ ++ K+ FL + TE L+ L + ++ + + S K
Sbjct: 723 HVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISECESSVNQLK 782
Query: 412 SDSPNVYTEKKEIAILRERLTELERKL 438
N +EI LR +L ++L
Sbjct: 783 ETLVN---RDREINSLRRQLDAAHKEL 806
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 57.4 bits (137), Expect = 5e-08
Identities = 61/233 (26%), Positives = 108/233 (46%), Gaps = 31/233 (13%)
Query: 258 MKDYLSQCQQEQESFIDYKSL----KENLARCWTLTEAEKMSFETQKTNLATENQYLRVS 313
+K L +QE+E + L ++ LA LTE ET ++ L E L+
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTE-----METLQSQLMAEKLQLQEQ 888
Query: 314 LEKEEKALSSLQEELNKLREQIRILEDKGTSTEL-VKENQKLKQHLEEEKQKKHSFLSQR 372
L+ E + + +E +L + + LE+ E V+E ++ QHL+ EK+K + +
Sbjct: 889 LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948
Query: 373 ETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLT 432
E L E + +++L+ E++ T A +L++L Q+ + + + EKK +L +R+
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEA---KLKKLEEEQIILEDQNCKLAKEKK---LLEDRIA 1002
Query: 433 ELERKLTFEQQRS---------------DLWERLYVEAKDQNGKQGTDGKKKG 470
E LT E+++S DL ERL E K + + T K +G
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Score = 56.2 bits (134), Expect = 1e-07
Identities = 100/513 (19%), Positives = 195/513 (38%), Gaps = 71/513 (13%)
Query: 46 EQEELQALQIEQGESSQNGTVLME-----ETAYPALEETSSTIEAEEQKIPEDSIYIGTA 100
E+E Q LQ E+ + QN L E E+A L+ T EA+ +K+ E+ I +
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL--- 983
Query: 101 SDDSDIVTLEPPKLEE--IGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPS 158
+D + + KL E I + EE + S+ + +
Sbjct: 984 -EDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-------------------AKLKN 1023
Query: 159 DDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKC 218
E+ + + ++R+ +KT E + +++Q E ++++ + +
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 219 VILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSL 278
+ A + + + ++ ++KI E ++ +S+ Q++ ES
Sbjct: 1084 ELQAALARVEE---------EAAQKNMALKKIRE-----LESQISELQEDLES------- 1122
Query: 279 KENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRIL 338
A + E QK +L E + L+ LE + ++ QE +K +++ IL
Sbjct: 1123 ----------ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172
Query: 339 EDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRG 398
+ L +E + + ++E +QK + + L + K +K LE+ + RG
Sbjct: 1173 KKT-----LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG 1227
Query: 399 ELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQ 458
EL L GK DS + KK A L+E + + +D +L VE +
Sbjct: 1228 ELANEVKVLLQGKGDSE--HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 459 NG--KQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK-EFVRHHKEKIKQAK 515
G Q K + +++ ++T +E + STK + V K ++
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 516 EAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKG 548
E +E + + D K + D G
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Score = 49.7 bits (117), Expect = 1e-05
Identities = 65/288 (22%), Positives = 126/288 (43%), Gaps = 26/288 (9%)
Query: 254 ELNDMKDYLSQCQQEQESFI-DYKSLKENLARCWTLTEAE---KMSFETQKTNLATENQY 309
EL+++ LSQ + D+ +L+ L L + E K+S T+ + E
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Query: 310 LRVSLEKEEKALSSLQEELNKLREQIRILEDK-GTSTELVKENQKLKQHLEEEKQKKHSF 368
R LE+EE+A +L++++ L Q+ ++ K S ++ +++K+ L QK
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL----QKDLEG 1396
Query: 369 LSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILR 428
LSQR E +LE+ + T L+ EL L H + + N+ ++K+ L
Sbjct: 1397 LSQRH---EEKVAAYDKLEKTK---TRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 429 ERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAK----NKSKET 484
+ K E+ R++ EA+++ K + + +A+ NK T
Sbjct: 1451 AEEKTISAKYAEERDRAE------AEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 485 FLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKST 532
+ + + D + S E + K ++Q E +K L++ D +++T
Sbjct: 1505 EMEDLMSSKDDVGKSVHE-LEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Score = 43.9 bits (102), Expect = 6e-04
Identities = 60/263 (22%), Positives = 120/263 (45%), Gaps = 24/263 (9%)
Query: 155 SQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSG 214
+Q D D+T + + +K + + E+E ++ QE + E +KRQ
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE--MIQLQEELAAAERAKRQAQQE 1702
Query: 215 LNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIH--EDELNDMK---DYLSQCQQEQ 269
++ LA IA S G G + ++++++L +I E+EL + + + ++ ++
Sbjct: 1703 RDE---LADEIANSSG----KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA 1755
Query: 270 ESFIDYKSLKENLARCWTL-TEAEKMSFETQKTNLATENQYLRVSLEKEEKA-LSSLQEE 327
ID + NL R E + E Q L + Q + +++ + KA +++L+ +
Sbjct: 1756 NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 328 LNKLREQI--RILEDKGTSTELVKENQKLKQHL---EEEKQKKHSFLSQRETLLTEAKML 382
+ +L EQ+ E + ++ + +KLK L ++E++ + Q + T K L
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875
Query: 383 KREL---ERERLVTTALRGELQQ 402
KR+L E E A R +LQ+
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQR 1898
Score = 43.1 bits (100), Expect = 0.001
Identities = 74/439 (16%), Positives = 191/439 (43%), Gaps = 39/439 (8%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSST-----IEAEEQKIPEDSIYIGTAS 101
+ +LQ LQ++ E + T L ++ +E + T +++ K+ +D + +
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL 1310
Query: 102 DDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDE 161
D+ + E + + + ++ VE+ ++S + +++ + +Q +D +
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Query: 162 SSSDETSNQPSPAFRRRRARKKTVS--ASESEDRLVAEQETEPSKELSKRQFSSGLNKCV 219
+++ A +R +K + + E+++ A + E +K +++
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD------ 1424
Query: 220 ILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLK 279
L++ + ++K+Q+ ++ +E Y + + + + ++
Sbjct: 1425 ---LLVDLDH---QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 280 ENLARCWT-----LTEAEKMS--FETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLR 332
+LAR E E+++ F T+ +L + + S+ + EK+ +L++++ +++
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 333 EQIRILEDKGTSTELVK-----ENQKLKQHLEEEKQ-KKHSFLSQRETLLTEAKMLKREL 386
Q+ LED+ +TE K Q +K E + Q + +++ L+ + + ++ EL
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL 1598
Query: 387 E---RERLVTTALRGELQ-QLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
E ++R + A R +L+ L + H S + N K++ L+ ++ + R+L +
Sbjct: 1599 EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL--DD 1656
Query: 443 QRSDLWERLYVEAKDQNGK 461
R+ E + +AK+ K
Sbjct: 1657 TRASR-EEILAQAKENEKK 1674
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 57.0 bits (136), Expect = 6e-08
Identities = 115/560 (20%), Positives = 226/560 (40%), Gaps = 97/560 (17%)
Query: 37 EPAPECSSLEQEELQA-LQIEQGESSQNGTVLME-----ETAYPALEETSSTIEAEEQKI 90
E A E ++EE+Q L+ Q ES GT L E A ALE T++ E + +
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE----TLKRENKNL 1554
Query: 91 PEDSIYIGTASDDSDIVTLEPPKLEEIGNQEVVIV---EEAQSSEDFNMGSSSSSQYTFC 147
E+ SD +D V+L ++E+ + + E Q++ + G+ +
Sbjct: 1555 QEE------ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608
Query: 148 QPETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELS 207
+ + S ++ + E + + R + +++ AS L AE
Sbjct: 1609 RIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQAS-----LDAETRARNEALRL 1663
Query: 208 KRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ 267
K++ LN + + GH T Q + Q R + +Q ++
Sbjct: 1664 KKKMEGDLND---------LELQLGH--ATRQATEAQAATRLMQ-----------AQLKE 1701
Query: 268 EQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEE 327
EQ + + L L + + E + + LA E + LR +LE+ E++ ++E
Sbjct: 1702 EQAGRDEEQRLAAEL-------HEQAQALERRASLLAAELEELRAALEQGERSRRLAEQE 1754
Query: 328 LNKLREQIRILEDKGTSTELVKENQKLKQHL-------EEEKQKKHSFLSQRETLLTEAK 380
L + E++ +L + T L+ + +KL+ L EE Q++ + + +T+A
Sbjct: 1755 LLEATERLNLLHSQNTG--LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAA 1812
Query: 381 MLKRELERERLVTTALRGELQQLSGS--QLHGK---SDSPNVYTEKKEIAILRERLTELE 435
M+ EL++E+ + L + L + +L + ++ + KK++ L ++ ELE
Sbjct: 1813 MMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELE 1872
Query: 436 RKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDA 495
+L EQ++ + EA K K+ + KN L +++ D
Sbjct: 1873 AELDAEQKK-------HAEALKGVRKHERRVKELAYQAEEDRKN------LARMQDLVDK 1919
Query: 496 MKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGAT 555
+++ K + K + ++A++ NL K+ + +H D + +R
Sbjct: 1920 LQSKVKSY----KRQFEEAEQQANTNLAKYRKA-----QHELDDAE--------ERADMA 1962
Query: 556 KEAAEKPRTVFSDYLHPQYK 575
+ A K R D L P++K
Sbjct: 1963 ETQANKLRARTRDALGPKHK 1982
Score = 47.4 bits (111), Expect = 5e-05
Identities = 72/319 (22%), Positives = 133/319 (41%), Gaps = 41/319 (12%)
Query: 238 IQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFE 297
+Q++ + + + + EDE D ++ ++ ++ + K ++L E EK + E
Sbjct: 962 VQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATE 1021
Query: 298 TQKTNLATENQYLRVS---LEKEEKALSSL-QEELNKLR-EQIRI---------LEDKGT 343
+ NL E L S L KE+KAL Q+ L L+ E+ R+ LE +
Sbjct: 1022 NKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVE 1081
Query: 344 STEL-VKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERE------RLVTTAL 396
E +++ +KL+ E K+K L + + +A K++LE + L +L
Sbjct: 1082 DLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSL 1141
Query: 397 RGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAK 456
R E +QL G+Q+ +K+I L+ R ELE +L E+ E+ EA
Sbjct: 1142 RVEDEQLLGAQM------------QKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189
Query: 457 DQNGKQGTDGKKKGGRGS-HRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAK 515
+ + ++ GG + R + +E LG ++ +E H+ + +
Sbjct: 1190 RELEELSERLEEAGGASAGQREGCRKREAELG-------RLRRELEEAALRHEATVAALR 1242
Query: 516 EAVKENLKKFSDSVKSTFR 534
E + + V S R
Sbjct: 1243 RKQAEGAAELGEQVDSLQR 1261
Score = 44.7 bits (104), Expect = 3e-04
Identities = 64/269 (23%), Positives = 114/269 (42%), Gaps = 38/269 (14%)
Query: 290 EAEKMSFETQ-KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
E +++S T+ K L + + L SLE+E+K + KL +++ + E V
Sbjct: 1062 EEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQ------ESV 1115
Query: 349 KENQKLKQHLEEEKQKKHSFLSQR------------------ETLLTEAKMLKRELERER 390
+ + KQ LEE+ +KK S LSQ + L A+ L+ ELE ER
Sbjct: 1116 ADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER 1175
Query: 391 LVTTALR-------GELQQLSG--SQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFE 441
+ EL++LS + G S K+E + R R ELE
Sbjct: 1176 AARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLR-RELEEAALRH 1234
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETF--LGSVKETFDAMKNS 499
+ R E + G+Q D ++ + + K++ + L + ET K S
Sbjct: 1235 EATVAALRRKQAEGAAELGEQ-VDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKAS 1293
Query: 500 TKEFVRHHKEKIKQAKEAVKENLKKFSDS 528
++ R +++++ +AK V+E ++ +D+
Sbjct: 1294 AEKLCRTYEDQLSEAKIKVEELQRQLADA 1322
Score = 35.8 bits (81), Expect = 0.15
Identities = 78/457 (17%), Positives = 176/457 (38%), Gaps = 42/457 (9%)
Query: 17 ISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPAL 76
I+ E +D+ + + + C L + ++Q +G+ + L +E
Sbjct: 929 ITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQL----EGKVKELSERLEDE------ 978
Query: 77 EETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNM 136
EE ++ + A +K+ ++ + DD + + K ++ +V + E ++ D ++
Sbjct: 979 EEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESV 1038
Query: 137 GSSSSSQYTF--CQPETVFSSQPSDDESSS---------DETSNQPSPAFRRRRARKKTV 185
+ + + + Q +D S+ + + + ++ R T
Sbjct: 1039 ARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTE 1098
Query: 186 SASES-EDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQ 244
A E L QE+ K+Q L K +++ + G +K +
Sbjct: 1099 RAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIK 1158
Query: 245 QLVRKIHE--DELNDMKDYLSQCQQEQ-ESFIDYKSLKENLARCWTLTEAEKMSFETQKT 301
+L + E +EL + ++ ++++ E+ + + L E L + ++ ++
Sbjct: 1159 ELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREA 1218
Query: 302 NLATENQYLRVSLEKEEKALSSLQ----EELNKLREQIRILEDKGTSTELVKENQKLKQH 357
L + L + + E +++L+ E +L EQ+ L+ +L KE +L+
Sbjct: 1219 ELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR--VRQKLEKEKSELRME 1276
Query: 358 LEE----------EKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQ 407
+++ K E L+EAK+ EL+R+ + RG LQ SG
Sbjct: 1277 VDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGEL 1336
Query: 408 LHGKSDSPNVYTE-KKEIAILRERLTELERKLTFEQQ 443
+ + ++ + A+ + L EL R+L E +
Sbjct: 1337 SRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESK 1373
Score = 35.4 bits (80), Expect = 0.20
Identities = 48/209 (22%), Positives = 88/209 (42%), Gaps = 26/209 (12%)
Query: 253 DELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRV 312
+EL + K L+ QE E ++ + A+C +L +A K L TE++ + +
Sbjct: 1433 EELEEAKKKLALRLQEAEEGVEAAN-----AKCSSLEKA--------KLRLQTESEDVTL 1479
Query: 313 SLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV--------KENQKLKQHLEEEKQK 364
LE+ A ++L + K R R LE++ E + +E++ L L +
Sbjct: 1480 ELERATSAAAALDK---KQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHG 1536
Query: 365 KHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQ--LHGKSDSPNVYTEKK 422
L ETL E K L+ E+ + +Q+L ++ L G+ E+
Sbjct: 1537 HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596
Query: 423 EIAILRERLTELERKLTFEQQRSDLWERL 451
E A+ E L +L Q ++++ +L
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKL 1625
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 56.6 bits (135), Expect = 8e-08
Identities = 86/350 (24%), Positives = 147/350 (42%), Gaps = 36/350 (10%)
Query: 238 IQIQKRQQLVRKIHE--DELNDMKDYLSQCQQEQESFIDYKSLKENL-----ARCWTLTE 290
+Q + +Q + K H EL D+K L Q S K+L+E+L C E
Sbjct: 305 LQSENLKQSIEKQHHLTKELEDIKVSL------QRSVSTQKALEEDLQIATKTICQLTEE 358
Query: 291 AEKMSFETQKTNLA-----TENQYLRVSLEKEEKALSSLQEELNKLREQIRIL--EDKGT 343
E E+ K A TE + SLE+ L + Q+ L K +Q++IL E +
Sbjct: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQRLEKNEDQLKILTMELQKK 415
Query: 344 STELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQL 403
S+EL +E KL + E E ++ L ++ETLL E K ++ E + L G LQ
Sbjct: 416 SSEL-EEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAR 474
Query: 404 SGS------QLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKD 457
QL + S Y+ KE+ L+ TELE + + + +L +E K+
Sbjct: 475 EKEVHDLEIQLTAITTSEQYYS--KEVKDLK---TELENEKLKNTELTSHCNKLSLENKE 529
Query: 458 QNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEA 517
+ + + NK +E + E + + + + +E++KQ ++
Sbjct: 530 LTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDE 589
Query: 518 VKENLKKFSDSVKSTFRHFKDTTKNIFD-EKGNKRFGATKEAAEKPRTVF 566
VK L K ++ + + ++ K I + ++ NK A K V+
Sbjct: 590 VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVY 639
Score = 51.2 bits (121), Expect = 3e-06
Identities = 68/302 (22%), Positives = 136/302 (45%), Gaps = 25/302 (8%)
Query: 265 CQQEQESFIDYKSLKENLARCWTLT-EAEKMSFETQKTNLATENQYLRVSLEKEEKALSS 323
C E+ + + L++N + LT E +K S E ++ T N+ V LE+ +K L
Sbjct: 385 CSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNK--EVELEELKKVLGE 442
Query: 324 LQEELNKLREQIRILED-KGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
+ L + ++ +I E+ KGT EL+ Q ++ + + + + + + + E K L
Sbjct: 443 KETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDL 502
Query: 383 KRELERERLVTTALRGE-----------LQQLSGSQLHGKSDSPNVYTEKKEIAILRERL 431
K ELE E+L T L Q+ S L K+ ++ KK+ + +++
Sbjct: 503 KTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQI 562
Query: 432 TELERKLTFEQQRSDL-WERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVK 490
L+ T Q R++L + R ++ K K D K + + R + ++K ++ ++
Sbjct: 563 ENLQE--TETQLRNELEYVREELKQKRDEVKCKLD-KSEENCNNLRKQVENKNKYIEELQ 619
Query: 491 ETFDAM-KNSTKEFVRHHKEKIKQAK-----EAVKENLKKFSDSVKSTFRHFKDTTKNIF 544
+ A+ K T E + + +IK K E+ K+ + +D+ + K + +N+
Sbjct: 620 QENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLL 679
Query: 545 DE 546
+E
Sbjct: 680 EE 681
Score = 46.2 bits (108), Expect = 1e-04
Identities = 100/504 (19%), Positives = 198/504 (39%), Gaps = 69/504 (13%)
Query: 42 CSSLEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTAS 101
C E++E Q + + ++ + V ET +LEE T E+Q++ ++ + +
Sbjct: 353 CQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRT---EQQRLEKNEDQLKILT 409
Query: 102 DDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDE 161
+ + E ++ ++ N + V +EE + +G + Y Q E +
Sbjct: 410 MELQKKSSELEEMTKLTNNKEVELEELKKV----LGEKETLLYENKQFEKI--------- 456
Query: 162 SSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVIL 221
++E +AR+K V E + + E SKE+ + K
Sbjct: 457 --AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNT 514
Query: 222 ALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKEN 281
L + + L K E +DM + + +QE + K +E
Sbjct: 515 ELTSHCN--------------KLSLENKELTQETSDMT---LELKNQQEDINNNKKQEER 557
Query: 282 LARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKA----LSSLQEELNKLREQIRI 337
+ L + E + ET+ T L E +Y+R L+++ L +E N LR+Q+
Sbjct: 558 M-----LKQIENLQ-ETE-TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV-- 608
Query: 338 LEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTAL 396
E+K E L +EN+ LK+ E ++ + + E K+ K ELE E
Sbjct: 609 -ENKNKYIEELQQENKALKKKGTAESKQLNVY---------EIKVNKLELELESAKQKF- 657
Query: 397 RGELQQLSGSQLHGKSDSP-NVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEA 455
GE+ ++ K S N+ E ++ ++ + +L++++ Q + E + +
Sbjct: 658 -GEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHK-IAEMVALME 715
Query: 456 KDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMK------NSTKEFVRHHKE 509
K ++ ++ G +++K + + + S++ +K E R KE
Sbjct: 716 KHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKE 775
Query: 510 KIKQAKEAVKENLKKFSDSVKSTF 533
K+K+ + LK+ D TF
Sbjct: 776 KLKREAKENTATLKEKKDKKTQTF 799
Score = 34.7 bits (78), Expect = 0.34
Identities = 57/320 (17%), Positives = 134/320 (41%), Gaps = 37/320 (11%)
Query: 267 QEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLA------------TENQYLRVSL 314
+ +E+ Y L N+ + T E ++ E + + E +Y +
Sbjct: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
Query: 315 EKEEKA---LSSLQEELNKLREQIRILEDKGTSTELVKENQKLK-QHLEEEKQKKHSFLS 370
+KE++ L + E+ NK+++ +LE+ ++E KL+ ++L++ +K+H
Sbjct: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTK 322
Query: 371 QRETL---LTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAIL 427
+ E + L + ++ LE + + T +L + +Q+ + + ++ +
Sbjct: 323 ELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHS--FVVTEF 380
Query: 428 RERLTELERKLTFEQQR----SDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNK--- 480
+ LE L EQQR D + L +E + ++ + K + + K
Sbjct: 381 ETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVL 440
Query: 481 -SKETFLGSVKE---TFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHF 536
KET L K+ + +K + +E + + QA+E +L+ ++ ++ +++
Sbjct: 441 GEKETLLYENKQFEKIAEELKGTEQELI-----GLLQAREKEVHDLEIQLTAITTSEQYY 495
Query: 537 KDTTKNIFDEKGNKRFGATK 556
K++ E N++ T+
Sbjct: 496 SKEVKDLKTELENEKLKNTE 515
Score = 30.0 bits (66), Expect = 8.3
Identities = 37/174 (21%), Positives = 75/174 (43%), Gaps = 13/174 (7%)
Query: 242 KRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAE-KMSFETQK 300
K Q+ + K + ++ +M + + + + + I+ + + L + ++ + S E +
Sbjct: 694 KLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIEL 753
Query: 301 TNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQ---KLKQH 357
+NL E ++ LE E + L+ E + ++ +DK T T L++ + KL
Sbjct: 754 SNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
Query: 358 LEEEKQKKHSFLS--------QRETLLTEAK-MLKRELERERLVTTALRGELQQ 402
+ +F S +R+ L T AK L L + V T + +LQQ
Sbjct: 814 AVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQ 867
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 56.6 bits (135), Expect = 8e-08
Identities = 87/392 (22%), Positives = 153/392 (39%), Gaps = 53/392 (13%)
Query: 254 ELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTL-TEAEKMSFETQKTNLATENQY--L 310
E+ + + L Q+++ I++K L + L L E + E ++ L ENQ +
Sbjct: 1540 EIESLNEVLKNYNQQKD--IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSM 1597
Query: 311 RVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV-------KENQKL----KQHLE 359
+ LE ++K L + + E+++ LED+ S K QK+ KQ L
Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657
Query: 360 EEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNV-- 417
+ ++K+ + E+ L+E +E ERE + ++ L + NV
Sbjct: 1658 QMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAA 1717
Query: 418 YTEKKE--------------IAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQG 463
YTE++E I++L+ LTE E+ L Q + + E + Q ++
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777
Query: 464 TDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAV--KEN 521
+ AK ++ +G ++E + V H EK + K + K+N
Sbjct: 1778 IKLEHA------EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK-EGGKNNIQAKQN 1830
Query: 522 LKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTENH 581
L+ D V+ T + K+ T I ++K + E R + T +
Sbjct: 1831 LENVFDDVQKTLQE-KELTCQILEQKIKELDSCLVRQKEVHRVEMEEL--------TSKY 1881
Query: 582 HNRGPTMQNDGRKEKPVHFKEFRKNTNSKKCS 613
Q DGR KP E +NT K S
Sbjct: 1882 EKLQALQQMDGR-NKPTELLE--ENTEEKSKS 1910
Score = 50.4 bits (119), Expect = 6e-06
Identities = 113/555 (20%), Positives = 230/555 (41%), Gaps = 56/555 (10%)
Query: 41 ECSSLEQEELQALQIEQGESSQNGTVL-MEETAYPALEETSSTIEAEEQKIPEDSIYIGT 99
E ++ E AL++ Q E N +L M + + + S +E QK +S+
Sbjct: 978 EAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN-QKEQIESLTEVH 1036
Query: 100 ASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTF-CQPETVFSSQP- 157
+ +D++++ KL + + I E ++ + F C+ E +
Sbjct: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096
Query: 158 -SDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQ-ETEPSKELSKRQFSSGL 215
++ D T N+ +++ A +++ E++ + E+ E + +K L + F L
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTF---L 1153
Query: 216 NKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIH--EDELNDMKDYLSQCQQE-QESF 272
+ ++ ++A +K +L K+ ++E +K + + ++
Sbjct: 1154 QEQLVELKMLAEE----------DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
Query: 273 IDYKSLKENLAR----CWTLTEA-------EKMSFETQKTN-LATENQYLRVSLEKEEKA 320
+++K L E LA C TEA E ++ + KTN + + + + K ++A
Sbjct: 1204 LEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA 1263
Query: 321 LSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAK 380
L +++L Q+R L ++ + + Q+ LEE++ + S + E+L+TE +
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNI--SFQQATHQLEEKENQIKSMKADIESLVTEKE 1321
Query: 381 MLKRE--------LERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLT 432
L++E E+E + T L+ EL + + K + + +K EI+ L ++LT
Sbjct: 1322 ALQKEGGNQQQAASEKESCI-TQLKKELSENINAVTLMKEE---LKEKKVEISSLSKQLT 1377
Query: 433 ELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKET 492
+L +L S+ E + Q ++ + + S + SKE S E
Sbjct: 1378 DLNVQLQNSISLSEK-EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI--SALEQ 1434
Query: 493 FDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDE---KGN 549
D N E+ + + + Q + VKE + +KS + KD N+ E + N
Sbjct: 1435 VDDWSNKFSEWKKKAQSRFTQHQNTVKE--LQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 550 KRFGATKEAAEKPRT 564
KRF K E ++
Sbjct: 1493 KRFDCLKGEMEDDKS 1507
Score = 49.7 bits (117), Expect = 1e-05
Identities = 77/394 (19%), Positives = 150/394 (38%), Gaps = 43/394 (10%)
Query: 179 RARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILA-------LVIAISMGF 231
++ K+ + SE + EQ E +EL K + K ++ L+ +
Sbjct: 303 QSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK 362
Query: 232 GHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEA 291
G + Q + L K E+E+ ++ + Q + E + K E A E
Sbjct: 363 GMVIAETKRQMHETLEMK--EEEIAQLRSRIKQMTTQGEELREQKEKSERAA----FEEL 416
Query: 292 EKMSFETQKTNLATENQYLRVSLEKEEKALS--------SLQEELNKLREQIRILEDKGT 343
EK QKT A L+ ++++ K + SLQ+EL+++++++ + K +
Sbjct: 417 EKALSTAQKTEEARRK--LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474
Query: 344 STELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQL 403
++ K + ++ L ++Q+ L RE E +K LE+ + + E +Q
Sbjct: 475 EEQIAKLQKLHEKELARKEQELTKKLQTREREFQE--QMKVALEKSQSEYLKISQEKEQQ 532
Query: 404 SGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQG 463
L + +KK I LTE E KL QQ ++ + +E + K
Sbjct: 533 ESLALE------ELELQKKAI------LTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 464 TDGKKKGG------RGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEA 517
+ K + NK + K +++K+ + +KQ +
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640
Query: 518 VKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKR 551
E L++ + K T K+ E+ N++
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEK 674
Score = 47.0 bits (110), Expect = 7e-05
Identities = 114/583 (19%), Positives = 238/583 (40%), Gaps = 116/583 (19%)
Query: 34 DSCEPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPED 93
+ E A + +E + L+ E E + +E+T+ EE +++ E ++ ++
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKT----IEKTS----EEERISLQQELSRVKQE 465
Query: 94 SIYIGTASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSE-DFNMGSSSSSQYTFCQPETV 152
+ + S + I L+ +E+ +E + ++ Q+ E +F Q +
Sbjct: 466 VVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQE-----------QMKVA 514
Query: 153 FSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRL---VAEQETEPSKELS-- 207
S+ S E Q S A +KK + +ESE++L E ET ++ L
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAI-LTESENKLRDLQQEAETYRTRILELE 573
Query: 208 ---KRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQ------------------QL 246
++ N+ LA+ + + T+ ++K + Q+
Sbjct: 574 SSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQV 633
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEA--EKMSF-ETQKTNL 303
+++ ++ E+ +++ +C+QE+E+ + K + A + E EK+ +T+ +L
Sbjct: 634 LKQQYQTEMEKLRE---KCEQEKETLLKDKEIIFQ-AHIEEMNEKTLEKLDVKQTELESL 689
Query: 304 ATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQH---LEE 360
++E + + K E+ LS L+++ +K+++++ D+ + + + +K+H ++
Sbjct: 690 SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQR 749
Query: 361 EKQKKHSFLSQRETLLTEA-KMLKR-ELERERLVTTALR--GELQQLSGS----QLHGKS 412
++ ++Q E LL E K LK + E L R GELQQ S Q + +
Sbjct: 750 TEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSA 809
Query: 413 DSPNVYTEKKEIAILRERLTELERKLTF--------EQQRSDLWERL---YVEAKD---Q 458
++++A L+++L +LE + E Q+ D+ L ++ +D Q
Sbjct: 810 THEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQ 869
Query: 459 NGKQGTDGKKK--------------GGRGSHRAKN--KSKETFLGSVKE------TFDAM 496
KQ ++ ++K G + + K KE + ++E
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 497 KNSTKEFVRH---------------HKEKIKQAKEAVKENLKK 524
K S KE H EK+KQ + ++E LKK
Sbjct: 930 KLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Score = 47.0 bits (110), Expect = 7e-05
Identities = 103/499 (20%), Positives = 202/499 (40%), Gaps = 61/499 (12%)
Query: 46 EQEELQALQIE-QGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDS 104
++EEL+AL+ + ES+ L + + E+K E+ GT S S
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEK--EEQYKKGTESHLS 1675
Query: 105 DIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSS 164
++ T KL+E +EV I+EE S + + + + + +D +
Sbjct: 1676 ELNT----KLQE-REREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730
Query: 165 DETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVIL-AL 223
+T + +R K+ + +++ +ET S + Q+ L K A
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEK----EETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 224 VIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDY-KSLKENL 282
GH ++ + ++ + E K+ + Q + F D K+L+E
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 283 ARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKG 342
C L + K + L + + RV +E+ L+S E+L L++ ++ +
Sbjct: 1847 LTCQILEQKIK----ELDSCLVRQKEVHRVEMEE----LTSKYEKLQALQQ----MDGRN 1894
Query: 343 TSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQ- 401
TEL++EN EEK K H L + K+L A +L+
Sbjct: 1895 KPTELLEENT-------EEKSKSH---------LVQPKLLSN--------MEAQHNDLEF 1930
Query: 402 QLSGSQLHGKSDSPNVYTEKKEIAILR-ERLTELE-RKLTFEQQRSDLWERLYVEAKDQN 459
+L+G++ + + +K++ +LR E ELE K ++Q+R E++ E +D
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE---EKIKQEQEDLE 1987
Query: 460 GKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
K + K+ + + K +E + ++KET + + E + H+E+ Q + +
Sbjct: 1988 LKHNSTLKQLMREFNTQLAQKEQELEM-TIKETINKAQEVEAELLESHQEETNQLLKKIA 2046
Query: 520 ENLKKFSDSVKSTFRHFKD 538
E D +K T + +++
Sbjct: 2047 EK----DDDLKRTAKRYEE 2061
Score = 47.0 bits (110), Expect = 7e-05
Identities = 42/186 (22%), Positives = 89/186 (47%), Gaps = 34/186 (18%)
Query: 238 IQIQKRQQLVRKIHEDELNDMKDYLSQ-----CQQEQESF-IDYKSLKENLARCW----- 286
+++QK +++RK H+ EL +K Q +QEQE + + S + L R +
Sbjct: 1947 VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLA 2006
Query: 287 ------------TLTEAEKMSFETQKTNLATENQYLRVSLEKEE--KALSSLQEELNKLR 332
T+ +A+++ E +++ NQ L+ EK++ K + EE+ R
Sbjct: 2007 QKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAR 2066
Query: 333 EQIRILEDKGTSTELVKENQKLKQHLEEEK---------QKKHSFLSQRETLLTEAKMLK 383
E+ + + T+L + +K +Q LE+E+ + + L+Q+ TL++++K+ +
Sbjct: 2067 EEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Query: 384 RELERE 389
+E +
Sbjct: 2127 QEFREQ 2132
Score = 36.2 bits (82), Expect = 0.12
Identities = 57/263 (21%), Positives = 108/263 (41%), Gaps = 18/263 (6%)
Query: 259 KDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEE 318
K Y Q Q Q+ +D ++ + L + EA+K T+ + Q L LEK+
Sbjct: 815 KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN 874
Query: 319 KALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTE 378
+ + L ++ E LED KE ++ KQ L E K++ L RE E
Sbjct: 875 SEMEQKVKSLTQVYES--KLEDGN------KEQEQTKQILVE---KENMILQMREGQKKE 923
Query: 379 AKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEI-AILRERLTELERK 437
++L ++L + L E + +Q + V + KE+ L+++L + E K
Sbjct: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQ---EKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 438 LTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMK 497
L E + + L L + K N K + + G A ++ + ++ + +
Sbjct: 981 LKKELENTAL--ELSQKEKQFNAKM-LEMAQANSAGISDAVSRLETNQKEQIESLTEVHR 1037
Query: 498 NSTKEFVRHHKEKIKQAKEAVKE 520
+ + ++K+ Q E ++E
Sbjct: 1038 RELNDVISIWEKKLNQQAEELQE 1060
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 56.6 bits (135), Expect = 8e-08
Identities = 106/476 (22%), Positives = 199/476 (41%), Gaps = 85/476 (17%)
Query: 46 EQEELQALQIEQGESSQNGTVL----MEETAYPALEETSSTIEAEE--QKIPEDSIYIGT 99
+++ +Q L I +GE V+ E+T LE + E E+ + + D+I
Sbjct: 77 KEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQE 136
Query: 100 ASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQP-- 157
S D+ +L+ + E + E + C TV+ +
Sbjct: 137 KSIGEDVYEKPISELDRL---------EEKQKETYRRMLEQLLLAEKCHRRTVYELENEK 187
Query: 158 ---SDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSG 214
+D + SD+ +N + R R K + E E A +E E +K L+K +
Sbjct: 188 HKHTDYMNKSDDFTN----LLEQERERLKKLL--EQEKAYQARKEKENAKRLNKLRDELV 241
Query: 215 LNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFID 274
K L LV M +Q QK Q L +K+ E+E +K S+ +++++ +
Sbjct: 242 KLKSFALMLVDERQMHIEQL--GLQSQKVQDLTQKLREEE-EKLKAITSKSKEDRQKLLK 298
Query: 275 YKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSL----------EKEEKALSSL 324
+ E+ A ++ E E+M+ + N + N+ LR+ L E+ K L
Sbjct: 299 LEVDFEHKASRFS-QEHEEMN--AKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKA 355
Query: 325 QEELNKLREQI-------------------RILEDKGTSTELVK---ENQKLKQHLEEEK 362
+EEL +LR++I R+LE +G E+ K + ++L++ L+EE+
Sbjct: 356 EEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEE 415
Query: 363 -------------QKKHSFLSQRETLLTEAK----MLKRELERERLVTTALRGELQQLSG 405
QK+ S L + E +++K L LE+E+ +T L EL+ +
Sbjct: 416 HHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKS 475
Query: 406 SQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFEQQRSDLWERLYVEAKDQNG 460
+ + EK E++ L++ LT+L+ + +R ++ E++ E + +G
Sbjct: 476 RVKELECSESRL--EKAELS-LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDG 528
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 55.5 bits (132), Expect = 2e-07
Identities = 65/302 (21%), Positives = 134/302 (44%), Gaps = 42/302 (13%)
Query: 247 VRKIHEDELNDMKDYLSQCQQ-EQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLA- 304
V+K E +LN+M+ LS + E+ KSL+ L + + + K N+A
Sbjct: 1614 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 305 ---------TENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQK-- 353
E + LR +E+ E++ ++EL + E++++L + TS L+ + +K
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS--LINQKKKMD 1731
Query: 354 -----LKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTAL---RGELQQLSG 405
L+ +EE Q+ + + + +T+A M+ EL++E+ + L + ++Q
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791
Query: 406 SQLHGKSDSPNVYTE--KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQG 463
H ++ + + KK++ L R+ ELE +L EQ+R+ +
Sbjct: 1792 DLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRN---------------AES 1836
Query: 464 TDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLK 523
G +K R +++E ++ + + + V+ +K + ++A+E NL
Sbjct: 1837 VKGMRKSERRIKELTYQTEEDRKNLLR--LQDLVDKLQLKVKAYKRQAEEAEEQANTNLS 1894
Query: 524 KF 525
KF
Sbjct: 1895 KF 1896
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/331 (20%), Positives = 130/331 (39%), Gaps = 29/331 (8%)
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCW-TLTEAEKM--SFETQKTNL 303
++ +E+ L ++ + + + QE D L E L T+ E EK+ E +K L
Sbjct: 1484 LKNAYEESLEHLETFKRENKNLQEEISD---LTEQLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 304 ATENQYLRVSLEKEEKALSSLQEELNKLREQI-RILEDKGTSTELVKEN-----QKLKQH 357
+ + SLE EE + Q E N+++ +I R L +K E K N L+
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 358 LEEE----------KQKKHSFLSQRETLLTEAKMLKRELERE-RLVTTALRGELQQLSGS 406
L+ E K+K L++ E L+ A + E +++ + + + L+ QL +
Sbjct: 1601 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1660
Query: 407 QLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQ------NG 460
N+ ++ +L+ L EL + ++ L E+ +E ++
Sbjct: 1661 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1720
Query: 461 KQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+ KKK + + + +E A K T + + K +Q A E
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1780
Query: 521 NLKKFSDSVKSTFRHFKDTTKNIFDEKGNKR 551
+KK + +H D + I + G K+
Sbjct: 1781 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/102 (29%), Positives = 58/102 (56%), Gaps = 3/102 (2%)
Query: 289 TEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIR-ILEDKGTSTEL 347
+++E S + + +L+TE L+ + E+ + L + + E L+E+I + E G+S +
Sbjct: 1463 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT 1522
Query: 348 VKENQKLKQHLEEEKQKKHSFLSQRETLL--TEAKMLKRELE 387
+ E +K+++ LE EK + S L + E L E K+L+ +LE
Sbjct: 1523 IHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Score = 44.3 bits (103), Expect = 4e-04
Identities = 77/380 (20%), Positives = 149/380 (39%), Gaps = 45/380 (11%)
Query: 238 IQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFE 297
IQ++ + + + + EDE + ++ ++ ++ + K ++L E EK + E
Sbjct: 913 IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE 972
Query: 298 TQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQH 357
+ NL E L + K K +LQE + + ++ EDK V K K
Sbjct: 973 NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK------VNTLTKAKVK 1026
Query: 358 LEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTA----LRGELQQLSGSQLHGKSD 413
LE++ L Q + + + + KR+LE + +T L + QQL +L K
Sbjct: 1027 LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLD-ERLKKKDF 1085
Query: 414 SPNVYTEK------------KEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGK 461
N + K++ L+ R+ ELE +L E+ E+L + + +
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145
Query: 462 QGTDGKKKGGRGSHRAK-NKSKETFLGSVKETFDAM----KNSTKEFVRHHKEKIKQAKE 516
++ GG S + + NK +E ++ + + + + H + + + E
Sbjct: 1146 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1205
Query: 517 AVKENLKKFSDSVKSTFRHFK----DTTKN---IFDEKGN---------KRFGATKEAAE 560
+ +NL++ ++ FK D T N I K N + + AE
Sbjct: 1206 QI-DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE 1264
Query: 561 KPRTVFSDYLHPQYKAPTEN 580
+ + +D + K TEN
Sbjct: 1265 ETQRSVNDLTSQRAKLQTEN 1284
Score = 43.5 bits (101), Expect = 7e-04
Identities = 52/231 (22%), Positives = 92/231 (39%), Gaps = 15/231 (6%)
Query: 244 QQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNL 303
Q++ R + E L + ++ +S + +NL R E EK F+ + ++
Sbjct: 1172 QKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1231
Query: 304 ATENQYLRVSLEKEEKALSSLQEELN----KLREQIRILEDKGTS-TELVKENQKLKQHL 358
+ + + + EK +L++++N K E R + D + +L EN +L + L
Sbjct: 1232 TSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQL 1291
Query: 359 EEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVY 418
+E++ + T + + LKR+LE E AL LQ S H Y
Sbjct: 1292 DEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQ----SARHDCDLLREQY 1347
Query: 419 TEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKK 469
E+ E EL+R L+ W Y Q ++ + KKK
Sbjct: 1348 EEETEAK------AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392
Score = 39.3 bits (90), Expect = 0.014
Identities = 101/549 (18%), Positives = 196/549 (35%), Gaps = 89/549 (16%)
Query: 44 SLEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAE----------------- 86
SLEQE+ + +E+ + G + + + + LE ++
Sbjct: 1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED 1096
Query: 87 --------EQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGS 138
++K+ E I ++ + K+E++ + +EE + G+
Sbjct: 1097 EQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Query: 139 SSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQ 198
+S + E F D E ++ ++ + A R++ E D L Q
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEAT--LQHEATAAALRKKHADSVAELGEQIDNL---Q 1211
Query: 199 ETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDM 258
+ E K +F L+ + +M QI K + + K+ + M
Sbjct: 1212 RVKQKLEKEKSEFKLELDD-------VTSNME--------QIIKAKANLEKMCRTLEDQM 1256
Query: 259 KDYLSQCQQEQESFIDYKSLK-----ENLARCWTLTEAEKMSFETQKTNLATENQY--LR 311
++ S+ ++ Q S D S + EN L E E + + + L Q L+
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 312 VSLEKEEKALSSLQEELNKLREQIRIL-----EDKGTSTELVKENQKLKQHLEEEKQKKH 366
LE+E KA ++L L R +L E+ EL + K + + + K
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 367 SFLSQRETLLTEA-KMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIA 425
+ QR L EA K L + L+ A+ + L + + E +++
Sbjct: 1377 TDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL-------EKTKHRLQNEIEDLM 1429
Query: 426 ILRERLTELERKLTFEQQRSDL----WERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKS 481
+ ER L +Q+ D W++ Y E++ + + +K R K
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSE-----LESSQKEARSLSTELFKL 1484
Query: 482 KETFLGSVK--ETFDAMKNSTKEFVR-------------HHKEKIKQAKEAVKENLKKFS 526
K + S++ ETF + +E + H EK+++ EA K L+
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Query: 527 DSVKSTFRH 535
+ +++ H
Sbjct: 1545 EEAEASLEH 1553
Score = 37.7 bits (86), Expect = 0.040
Identities = 34/145 (23%), Positives = 67/145 (46%), Gaps = 16/145 (11%)
Query: 258 MKDYLSQCQQEQESFI---DYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSL 314
+K L ++E+E ++ LKE L + +EA + E + +L E L++ +
Sbjct: 836 IKPLLKSAEREKEMASMKEEFTRLKEALEK----SEARRKELEEKMVSLLQEKNDLQLQV 891
Query: 315 EKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRET 374
+ E+ L+ +E ++L + LE K VKE + + LE+E++ +++
Sbjct: 892 QAEQDNLADAEERCDQLIKNKIQLEAK------VKE---MNERLEDEEEMNAELTAKKRK 942
Query: 375 LLTEAKMLKRELERERLVTTALRGE 399
L E LKR+++ L + E
Sbjct: 943 LEDECSELKRDIDDLELTLAKVEKE 967
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 55.5 bits (132), Expect = 2e-07
Identities = 101/524 (19%), Positives = 199/524 (37%), Gaps = 49/524 (9%)
Query: 46 EQEELQALQIEQGESS--QNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASD- 102
E E LQA Q E QN T++ E + L +E E Q++ E + G A
Sbjct: 74 ENEMLQAKLHSQEEDFRLQNSTLMAE---FSKLCSQMEQLEQENQQLKEGAAGAGVAQAG 130
Query: 103 ---DSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSD 159
D +++ L+ N + + + F+ S TV + P
Sbjct: 131 PLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLA 190
Query: 160 DESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCV 219
+ E + + + S+ ++E + E+ + S++L K+Q S
Sbjct: 191 EVELKWEMEKEEKRLLWEQLQGLE--SSKQAETSRLQEELAKLSEKLKKKQES------- 241
Query: 220 ILALVIAISMGFGHFYGTIQ-IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSL 278
L F I+ +Q+R++ K ++ L Q D +
Sbjct: 242 FCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQG 301
Query: 279 K--ENLARCWTLTEA---EKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLRE 333
+ E+ A L + + + Q L EN LR SL E+ ++ +ELN LRE
Sbjct: 302 ERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLRE 361
Query: 334 Q-----IRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELER 388
Q + + + +L+ + L L+E + L Q + + E + L +EL+
Sbjct: 362 QTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQE 421
Query: 389 ERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLW 448
R + L +L+ L KS + E+ LR L + +E++ +L
Sbjct: 422 ARKSAEKRKAMLDELAMETLQEKSQ----HKEELGAVRLRHEKEVLGVRARYERELRELH 477
Query: 449 ERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKE------TFDAMKNSTKE 502
E K+ + + +G +A+ + ET +V+E + D K +
Sbjct: 478 E----------DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFER 527
Query: 503 FVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDE 546
++ +E ++Q ++ +E LK+ + + + ++ +++ D+
Sbjct: 528 RLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQ 571
Score = 39.3 bits (90), Expect = 0.014
Identities = 33/129 (25%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 252 EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLR 311
E L + ++ L Q QQEQE E L +C AE E + ++ + + +
Sbjct: 526 ERRLKEAEESLQQQQQEQE---------EALKQCREQHAAELKGKEEELQDVRDQLEQAQ 576
Query: 312 VSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQ 371
+ K +SSL++E+ + RILE KG++ + LK+ L E+++ +
Sbjct: 577 EERDCHLKTISSLKQEVKDTVDGQRILEKKGSAA-----LKDLKRQLHLERKRADKLQER 631
Query: 372 RETLLTEAK 380
+ +LT +K
Sbjct: 632 LQDILTNSK 640
Score = 37.7 bits (86), Expect = 0.040
Identities = 50/219 (22%), Positives = 98/219 (44%), Gaps = 28/219 (12%)
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATE 306
+R++HED+ ++ Q ++E+ + ++L++ + +A+ S + K
Sbjct: 473 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE----LQAQVHSMDGAKGWFERR 528
Query: 307 NQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKH 366
+ SL+++++ +E L + REQ E KG EL Q ++ LE+ ++++
Sbjct: 529 LKEAEESLQQQQQ---EQEEALKQCREQ-HAAELKGKEEEL----QDVRDQLEQAQEERD 580
Query: 367 SFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAI 426
L +L E +K ++ +R++ L+ L QLH E+K
Sbjct: 581 CHLKTISSLKQE---VKDTVDGQRILEKKGSAALKDLK-RQLH---------LERKRADK 627
Query: 427 LRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTD 465
L+ERL ++ LT + RS L E + E + Q D
Sbjct: 628 LQERLQDI---LTNSKSRSGLEELVLSEMNSPSRTQTGD 663
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 55.1 bits (131), Expect = 2e-07
Identities = 65/302 (21%), Positives = 134/302 (44%), Gaps = 42/302 (13%)
Query: 247 VRKIHEDELNDMKDYLSQCQQ-EQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLA- 304
V+K E +LN+M+ LS + E+ KSL+ L + + + K N+A
Sbjct: 1616 VKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1675
Query: 305 ---------TENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
E + LR +E+ E++ ++EL + E++++L + TS L+ + +K++
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS--LINQKKKME 1733
Query: 356 QHL-------EEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTAL---RGELQQLSG 405
L EE Q+ + + + +T+A M+ EL++E+ + L + ++Q
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1793
Query: 406 SQLHGKSDSPNVYTE--KKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQG 463
H ++ + + KK++ L R+ ELE +L EQ+R+ +
Sbjct: 1794 DLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRN---------------AES 1838
Query: 464 TDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLK 523
G +K R +++E ++ + + + V+ +K + ++A+E NL
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLR--LQDLVDKLQLKVKAYKRQAEEAEEQANTNLS 1896
Query: 524 KF 525
KF
Sbjct: 1897 KF 1898
Score = 42.7 bits (99), Expect = 0.001
Identities = 66/329 (20%), Positives = 129/329 (39%), Gaps = 25/329 (7%)
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDY-KSLKENLARCWTLTEAEKMSFETQKTNLAT 305
++ +E+ L ++ + + + QE D + L E L + K E +K L +
Sbjct: 1486 LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQ-LEVEKLELQS 1544
Query: 306 ENQYLRVSLEKEEKALSSLQEELNKLREQI-RILEDKGTSTELVKENQK-----LKQHLE 359
+ SLE EE + Q E N+++ +I R L +K E K N + L+ L+
Sbjct: 1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD 1604
Query: 360 EE----------KQKKHSFLSQRETLLTEAKMLKRELERE-RLVTTALRGELQQLSGSQL 408
E K+K L++ E L+ A + E +++ + + + L+ QL +
Sbjct: 1605 AETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1664
Query: 409 HGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQ------NGKQ 462
N+ ++ +L+ L EL + ++ L E+ +E ++
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1724
Query: 463 GTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENL 522
+ KKK + +++ +E A K T + + K +Q A E +
Sbjct: 1725 LINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1784
Query: 523 KKFSDSVKSTFRHFKDTTKNIFDEKGNKR 551
KK + +H D + I + G K+
Sbjct: 1785 KKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1813
Score = 42.0 bits (97), Expect = 0.002
Identities = 76/376 (20%), Positives = 157/376 (41%), Gaps = 37/376 (9%)
Query: 238 IQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFE 297
IQ++ + + + + EDE + ++ ++ ++ + K ++L E EK + E
Sbjct: 915 IQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 974
Query: 298 TQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQH 357
+ NL E L + K K +LQE + + +++ EDK S L K KL+Q
Sbjct: 975 NKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS--LSKSKVKLEQQ 1032
Query: 358 -------LEEEKQKKHSFLSQRETLLTEAKMLKR---ELERERLVTTALRGELQQLSGSQ 407
LE+EK+ + + L + K+ + +LE ++L + + ++ +Q
Sbjct: 1033 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE-KLKKKEFDINQ 1091
Query: 408 LHGKSDSPNVYT--EKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTD 465
+ K + V +K++ + R+ ELE +L E+ E+L + + +
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1151
Query: 466 GKKKGGRGSHRAK-NKSKETFLGSVKETFDAM----KNSTKEFVRHHKEKIKQAKEAVKE 520
++ GG S + + NK +E ++ + + + + H + + + E + +
Sbjct: 1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI-D 1210
Query: 521 NLKKFSDSVKSTFRHFK----DTTKN---IFDEKGN-KRFGATKE--------AAEKPRT 564
NL++ ++ FK D T N I K N ++ T E E+ +
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQR 1270
Query: 565 VFSDYLHPQYKAPTEN 580
+D+ + K TEN
Sbjct: 1271 SLNDFTTQRAKLQTEN 1286
Score = 42.0 bits (97), Expect = 0.002
Identities = 64/316 (20%), Positives = 124/316 (39%), Gaps = 51/316 (16%)
Query: 177 RRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
+++ ++ E E+ L AE+ E + S L + + + G
Sbjct: 1107 QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEE-----ISERLEEAGGATSV 1161
Query: 237 TIQIQKR-----QQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEA 291
I++ K+ Q++ R + E L + ++ +S + +NL R E
Sbjct: 1162 QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK 1221
Query: 292 EKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKEN 351
EK F+ + ++ + + + + EK +L+++ N+ R +
Sbjct: 1222 EKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVK----------------- 1264
Query: 352 QKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKREL-ERERLVTTALRGEL---QQLSG-- 405
LEE ++ + F +QR L TE L R+L E+E L++ RG+L QQ+
Sbjct: 1265 ------LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK 1318
Query: 406 SQLHGKSDSPN-----VYTEKKEIAILRERL-------TELERKLTFEQQRSDLWERLYV 453
QL + + N + + + + +LRE+ EL+R L+ W Y
Sbjct: 1319 RQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1378
Query: 454 EAKDQNGKQGTDGKKK 469
Q ++ + KKK
Sbjct: 1379 TDAIQRTEELEEAKKK 1394
Score = 40.8 bits (94), Expect = 0.005
Identities = 30/102 (29%), Positives = 56/102 (54%), Gaps = 3/102 (2%)
Query: 289 TEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIR-ILEDKGTSTEL 347
+++E S + + +L+TE L+ + E+ + L + + E L+E+I + E G +
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN 1524
Query: 348 VKENQKLKQHLEEEKQKKHSFLSQRETLL--TEAKMLKRELE 387
V E +K+++ LE EK + S L + E L E K+L+ +LE
Sbjct: 1525 VHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE 1566
Score = 34.7 bits (78), Expect = 0.34
Identities = 61/309 (19%), Positives = 129/309 (41%), Gaps = 59/309 (19%)
Query: 253 DELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTL--------TEAEKMSFETQKTNLA 304
+EL + K L+Q Q+ E ++ + A+C +L E E + + +++N A
Sbjct: 1386 EELEEAKKKLAQRLQDAEEAVEAVN-----AKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440
Query: 305 T------ENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHL 358
+ + ++ E ++K S Q EL +++ R L STEL K ++ L
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEES-QSELESSQKEARSL-----STELFKLKNAYEESL 1494
Query: 359 E--EEKQKKHSFLSQRETLLTEA-----------KMLKRELERERLVTTALRGELQQLSG 405
E E ++++ L + + LTE + ++++LE E+L L+ L++
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKL---ELQSALEEAEA 1551
Query: 406 SQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTD 465
S H + E +I E+ERKL + + +E +N ++ D
Sbjct: 1552 SLEHEEGKILRAQLEFNQIK------AEIERKLAEKDEE--------MEQAKRNHQRVVD 1597
Query: 466 GKKKGGRGSHRAKN---KSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENL 522
+ R++N + K+ G + E + + ++++K + +K+
Sbjct: 1598 SLQTSLDAETRSRNEVLRVKKKMEGDLNE-MEIQLSHANRMAAEAQKQVKSLQSLLKDTQ 1656
Query: 523 KKFSDSVKS 531
+ D+V++
Sbjct: 1657 IQLDDAVRA 1665
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 54.7 bits (130), Expect = 3e-07
Identities = 63/286 (22%), Positives = 125/286 (43%), Gaps = 30/286 (10%)
Query: 240 IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
+Q+ ++ KI + + K+ Q E + I SLK L E K+
Sbjct: 1211 VQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEI 1270
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
+ +++L+ S E+ ++ LS+ Q+ + L+E+ R + + + E+ K++ H
Sbjct: 1271 TSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVH-N 1329
Query: 360 EEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYT 419
KQ+K+ +SQ ET + K+E E ++ L+ +LQ DS N
Sbjct: 1330 VLKQQKNKSMSQAET-----EGAKQEREHLEMLIDQLKIKLQ-----------DSQNN-- 1371
Query: 420 EKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKN 479
L+ ++EL+ T + + L ER ++ K+ +K S
Sbjct: 1372 -------LQINVSELQ---TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1421
Query: 480 KSKET-FLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKK 524
KS+ T + + + ++NS ++ VRH +E+ ++ E +++ L K
Sbjct: 1422 KSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSK 1467
Score = 49.7 bits (117), Expect = 1e-05
Identities = 69/295 (23%), Positives = 116/295 (39%), Gaps = 30/295 (10%)
Query: 278 LKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRI 337
LKE + +LTE EK F + N E E+EE+ + L +++ + +
Sbjct: 582 LKELEGKINSLTE-EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 338 LEDK-----GTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLV 392
LE K G E +KE + Q LE+ + +E L E K L E +
Sbjct: 641 LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNK---- 696
Query: 393 TTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLY 452
L E +QLS V+ +KE IL+E +T+LE+KL + D +L
Sbjct: 697 ---LSSEKKQLSRDL--------EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745
Query: 453 VEAKDQNGKQGTD----GKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHK 508
+ Q T K+ G S ++ K L +V E+ +
Sbjct: 746 ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
Query: 509 EKIKQAKEAVK---ENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAE 560
EK+ + ++ +K E + +KS R ++ + + K + + KEA +
Sbjct: 806 EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQ--EKVLLRKELEEIQSEKEALQ 858
Score = 49.3 bits (116), Expect = 1e-05
Identities = 121/577 (20%), Positives = 246/577 (42%), Gaps = 78/577 (13%)
Query: 24 IEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGESSQNGTVLMEETAYPALEETSSTI 83
+ L ++ +S +SL++E LQ I Q E + LM + +E ++
Sbjct: 216 VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE----LMCQ-----IEASAKEH 266
Query: 84 EAEEQKIPE--DSIYIGTASDDSDIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSS 141
EAE K+ E +++ + + +I +LE + + +++D + S
Sbjct: 267 EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKAT------SNANQDNQICSILL 320
Query: 142 SQYTFCQP---ETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTVSASESEDRLVAEQ 198
+ TF + E V + + E S + + + K + A +D E+
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHER 380
Query: 199 ETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQ-QLVRKIHEDELND 257
E K +++ + CVI L ++ F T++ R+ Q +++ H+ E+++
Sbjct: 381 EDLEFK-INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISE 439
Query: 258 MKD-YLS------------------QC----QQEQESFIDYKSLKENLARCWTLT--EAE 292
+ + +LS QC Q++QE+ ++Y+SL+E + T A
Sbjct: 440 LNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAG 499
Query: 293 KMS--FETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLR-EQIRILEDKGTSTELVK 349
K+S FE+ K A++ L+ L +L E +N+L+ E ++L + ELV
Sbjct: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQ----ELVP 555
Query: 350 ENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLH 409
E + ++L+E+ LSQR+T+L E + L E+ + +L S H
Sbjct: 556 ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEK------DDFINKLKNS--H 607
Query: 410 GKSDSPNVYTEKKEIAILRERLTELERKLTF----EQQRSDLWERL--YVEAKDQNGKQG 463
+ D+ + E++E IL E ++E+ + + EQ+ ++L L ++ KDQN
Sbjct: 608 EEMDNFHKKCEREERLIL-ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQN---- 662
Query: 464 TDGKKKGGRGSHRAKNKSKETFLGSVKETFD---AMKNSTKEFVRHHKEKIKQAKEAV-K 519
D K + + ++ KE VK ++ + + K+ R + + Q ++ + K
Sbjct: 663 -DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 520 ENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATK 556
E++ + ++ + K + +E+ K F T+
Sbjct: 722 EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQ 758
Score = 43.1 bits (100), Expect = 0.001
Identities = 103/560 (18%), Positives = 206/560 (36%), Gaps = 111/560 (19%)
Query: 2 SENSSDSDSSCGWTVISHEGSDIEMLNSVTPTDSCEPAPECSSLEQEELQALQIEQGESS 61
SE S DS+ V+ G + +N +C+ Q + + L++E+
Sbjct: 768 SEVSEDSEEKDVVNVLQAVGESLAKINE----------EKCNLAFQRDEKVLELEKEIKC 817
Query: 62 QNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDIVTLEPPKLEEIGNQE 121
L EE+ E S + E++K+ L +LEEI +++
Sbjct: 818 -----LQEESVVQCEELKSLLRDYEQEKV------------------LLRKELEEIQSEK 854
Query: 122 VVIVEEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAF------ 175
+ + ++ N + +Q Q E V + S E N+ F
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT------CSKSEIHNEKEKCFIKEHEN 908
Query: 176 ----------RRRRARKKTVSASESEDRLVAEQETEPSKELSKR---------QFSSGLN 216
R RRA + S ++ V KEL ++ + +N
Sbjct: 909 LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKIN 968
Query: 217 KCVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELN-DMKDYLSQCQQEQESFIDY 275
K ++A+ + Q K + + +D+L+ M+D + + + ++Y
Sbjct: 969 KIKLVAVKAKKELDSSR--KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEY 1026
Query: 276 KSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQI 335
+ E L + + +FE + +L + + + E L + L+
Sbjct: 1027 EKQSEQL----DVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNA 1082
Query: 336 RILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTA 395
++LE + E+ + + + LE EK +K + + T + E + L+ +L++E+
Sbjct: 1083 KLLEVQ--ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQK 1140
Query: 396 LRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEA 455
EL+ + K D+ EIA + EL +KLT +++ E L E
Sbjct: 1141 TMQELELV-------KKDAQQTTLMNMEIADYERLMKELNQKLT---NKNNKIEDLEQEI 1190
Query: 456 KDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAK 515
K Q KQ T ++E ++++S V+ ++EK + K
Sbjct: 1191 KIQKQKQET------------------------LQEEITSLQSS----VQQYEEKNTKIK 1222
Query: 516 EAVKENLKKFSDSVKSTFRH 535
+ + + K+ +DS ++ H
Sbjct: 1223 QLLVKTKKELADSKQAETDH 1242
Score = 40.4 bits (93), Expect = 0.006
Identities = 45/214 (21%), Positives = 106/214 (49%), Gaps = 30/214 (14%)
Query: 239 QIQKRQQLVRKIHEDELNDMKDYLSQCQQE----QESFIDYKSLKENLARCWTLTEAEKM 294
++QK Q++ K H +N++++ Q Q+E Q++ + + +K++ A+ TL E
Sbjct: 1107 KLQKEQKI--KEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKD-AQQTTLMNMEIA 1163
Query: 295 SFE----------TQKTNLATE-NQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGT 343
+E T K N + Q +++ +K+E +LQEE+ L+ ++ E+K
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQE----TLQEEITSLQSSVQQYEEK-- 1217
Query: 344 STELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQL 403
+T++ + K K+ L + KQ + L + +L E + ++++E ++ + E ++
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKI 1277
Query: 404 SGSQLHGKSDSPNVYTEKKEIAILRERLTELERK 437
H K+ + ++ ++ ++R+T L+ +
Sbjct: 1278 ---HEHLKTSAEQ---HQRTLSAYQQRVTALQEE 1305
Score = 38.5 bits (88), Expect = 0.023
Identities = 60/304 (19%), Positives = 118/304 (38%), Gaps = 47/304 (15%)
Query: 290 EAEKMSFETQKTNLAT---ENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE 346
EAEK+ E + AT E + L+V L+KE+K L +EL ++ +D +T
Sbjct: 1104 EAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVK------KDAQQTTL 1157
Query: 347 LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGS 406
+ E ++ ++E QK + ++ E L E K+ K++ E + T+L+ +QQ
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK 1217
Query: 407 QLHGKSDSPNVYTEKKEIAILRERLTE-------LERKLTFEQQRSDLWERLYVEAKDQN 459
K + KKE+A ++ T+ L+ +L QQ+ ++++ E +
Sbjct: 1218 NTKIKQ---LLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 460 GKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
K + E + + +++++ +E +
Sbjct: 1275 HK---------------------------IHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307
Query: 520 ENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVFSDYLHPQYKAPTE 579
K +V S F +K N+ ++ NK + K + L Q K +
Sbjct: 1308 A-AKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
Query: 580 NHHN 583
+ N
Sbjct: 1367 DSQN 1370
Score = 31.2 bits (69), Expect = 3.7
Identities = 65/271 (23%), Positives = 113/271 (41%), Gaps = 45/271 (16%)
Query: 287 TLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQ------EELNKLREQIRILED 340
TL + + + F ++ L + + LEKE + L S + + L E++ L
Sbjct: 24 TLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLL 83
Query: 341 KGTSTE-----LVKENQKLKQHLEEEKQK---KHSFLSQRE-TLLTEAKMLKRELERERL 391
+ TE L KEN K+KQ +E+ K H L Q + E + LK EL R
Sbjct: 84 EKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRS 143
Query: 392 VTTALRGELQ-----------QLSGSQLHGKSDSPNVYTEKKEIAILR----ERLTELER 436
+ + LQ +LS + NV ++EI +R E++ L++
Sbjct: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK 203
Query: 437 KL---TFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETF 493
+L T E++ + + +EA Q+ ++ + ++ + K VKE
Sbjct: 204 QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQE-------ELLQLKAIHQEEVKELM 256
Query: 494 DAMKNSTKEFVRHHKEKIKQAKEAVKENLKK 524
++ S KE H+ +I + E +KENL K
Sbjct: 257 CQIEASAKE----HEAEINKLNE-LKENLVK 282
>gi|238908495 similar to pleckstrin homology domain protein (5V327)
[Homo sapiens]
Length = 506
Score = 54.7 bits (130), Expect = 3e-07
Identities = 77/329 (23%), Positives = 132/329 (40%), Gaps = 52/329 (15%)
Query: 257 DMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEK 316
+ ++YL + +E E + +E L R + EAEK FE L E + ++ LE
Sbjct: 162 EKQEYLDKLMEETEELCLQREQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELEL 221
Query: 317 EEKALSSLQEELNKLREQIRILE--------DKGTSTELVKENQKLKQHLEEEKQKK--- 365
+ L +++E +LR L+ +K + E+++EN+ Q L + ++
Sbjct: 222 TARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPS 281
Query: 366 ---HSFLSQRE---TLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYT 419
HS L Q E L E K+L + +E + E ++ SQ +S T
Sbjct: 282 GGLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNSLQELT 341
Query: 420 EKKEIAILRERLTELERKLTFE-QQRSDLWERL-YVEAKDQNGKQGTDGKKKGGRGSHRA 477
+K+ + ER+L E + R DL RL E ++ +QG + K
Sbjct: 342 AEKQ---------QAERELKAEVKVRMDLERRLREAEGALRSLEQGLNSK---------V 383
Query: 478 KNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFK 537
+NK KE + M+ R +E I+ A E K +K++ K
Sbjct: 384 RNKEKE----------ERMRADVSHLKRFFEECIRNA-----ELEAKMPVIMKNSVYIHK 428
Query: 538 DTTKNIFDEKGNKRFGATKEAAEKPRTVF 566
T+ I + ++R +T KP F
Sbjct: 429 AATRRIKSCRFHRRRSSTSWNDMKPSQSF 457
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 54.7 bits (130), Expect = 3e-07
Identities = 111/527 (21%), Positives = 209/527 (39%), Gaps = 47/527 (8%)
Query: 48 EELQALQIEQGESSQNGTVLMEETAYPALEETS---STIEAEEQKIPEDSIYIGTASDDS 104
+EL + ++ Q T L++E +E S S +E E ++ I D
Sbjct: 219 QELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDI 278
Query: 105 DIVTLEPPKLEEIGNQEVVIVEEAQSSEDFNMGSSSSSQY--TFCQPETVFSSQPSDDES 162
D + K E+ N+ + V E +S+ + + + SS Y T F ++ E
Sbjct: 279 DKIR----KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE 334
Query: 163 SSDETSNQPSPAFRRRRARKKTVSASES---EDRLVAEQETE--PSKELSKRQFSSGLNK 217
+ + N+ + R+ ++ + +E E R EQ + P + QFS N+
Sbjct: 335 NKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNE 394
Query: 218 CVILALVIAISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKS 277
+ L + + H GT + Q V I DE++ K ++ Q +++ +
Sbjct: 395 SLQLKAHLDEARTLLH--GTRGTHQHQ--VELIERDEVSLHKKLRTEVIQLEDTLAQVRK 450
Query: 278 LKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRI 337
E E + E ++T LA Q ++ E +SSLQ ++L
Sbjct: 451 ------------EYEMLRIEFEQT-LAANEQAGPINREMRH-LISSLQNHNHQL------ 490
Query: 338 LEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKREL--ERERLVTTA 395
KG ++ ++ + L + + + S L Q ++ + K EL + E L + +
Sbjct: 491 ---KGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQS 547
Query: 396 LRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEA 455
+ Q +++ K D E++E RER E E++ E+Q+ E+ A
Sbjct: 548 SASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSA 607
Query: 456 KDQNGKQGTDGKKKGGRGSHRAK--NKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQ 513
KD+ + DG+KK + K K + +K D +++ KE + K ++
Sbjct: 608 KDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKE--QRDKVQLMA 665
Query: 514 AKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAE 560
A++ K L+ +K K K + DE ++ A +E E
Sbjct: 666 AEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIE 712
Score = 45.1 bits (105), Expect = 2e-04
Identities = 66/330 (20%), Positives = 133/330 (40%), Gaps = 25/330 (7%)
Query: 126 EEAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETSNQPSPAFRRRRARKKTV 185
E A+ D SS SS Q + D+E E + R R K+
Sbjct: 532 EPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERE--REREREKEKE 589
Query: 186 SASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQIQKRQQ 245
E + +E+E + +K+ K + G K + + I + + QK +
Sbjct: 590 REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQ-----ESQKEMK 644
Query: 246 LVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLAT 305
L+ ++ + +D + E++S + + L++ L L + EK + +A
Sbjct: 645 LLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLK---DLEDKEKK----ENKKMAD 697
Query: 306 ENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTST-----ELVKENQKLKQHLEE 360
E+ ++ +E+ + LQ++L +++ L + T ++ ++N +L Q L E
Sbjct: 698 EDALRKIRAVEEQ--IEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLRE 755
Query: 361 EKQKKHSFLSQRETLLTEAKMLKRELER--ERLVTTALRGELQQLSGSQLHGKSD--SPN 416
+ +S+R K+LK E E ++++T + + Q +L K N
Sbjct: 756 KDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSN 815
Query: 417 VYTEKKEIAILRERLTELERKLTFEQQRSD 446
+ T +KE+ + + L +RK Q +D
Sbjct: 816 IGTGEKELGLRTQALEMNKRKAMEAAQLAD 845
Score = 31.2 bits (69), Expect = 3.7
Identities = 46/225 (20%), Positives = 89/225 (39%), Gaps = 29/225 (12%)
Query: 310 LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFL 369
L+ +E +A+S + +KL+E++ +L K S + + +EE Q+ +SFL
Sbjct: 174 LQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLI--------VEEAVQELNSFL 225
Query: 370 SQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRE 429
+Q L E L +E R + SQ K S V T + +++L
Sbjct: 226 AQENMRLQELTDLLQEKHR---------------TMSQEFSKLQS-KVETAESRVSVLES 269
Query: 430 RLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGR---GSHRAKNKSKETFL 486
+ +L+ + ++R R E ++ +G G G+ + E
Sbjct: 270 MIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
Query: 487 GSVKETFDAMKNSTKEF--VRHHKEKIKQAKEAVKENLKKFSDSV 529
++E + +N E +R E++ E +K L+ + V
Sbjct: 330 AELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQV 374
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 54.7 bits (130), Expect = 3e-07
Identities = 115/583 (19%), Positives = 230/583 (39%), Gaps = 88/583 (15%)
Query: 23 DIEMLNSVTPTDSCEPAPECSSLEQE-ELQALQIEQGESSQNGTVLMEETAYP------- 74
+IE ++++ +++ C+ LE++ E +QI+Q +S + +E
Sbjct: 56 EIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQI 115
Query: 75 ALEETSSTIEAEEQKIPEDS-IYIGTAS----------------DDSDI--VTLEPPKLE 115
AL++ +++ Q +P + + TAS DD D + ++
Sbjct: 116 ALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN 175
Query: 116 EIGNQEVVIVEE-------AQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSDETS 168
+ N+ + E AQ+S+ G+ +S Q C+ + + + D+
Sbjct: 176 RLSNEVSRLESEVGHWRHIAQTSKA--QGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQ 233
Query: 169 NQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFS----SGLNKCVILALV 224
++ S + + +S E+ E+ E + L ++ S + L+K +
Sbjct: 234 HEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKT 293
Query: 225 IAISMGFGHFYGTIQIQKRQQLVRKIH-EDELNDMKDYLSQCQQEQESFIDYKSLKENLA 283
I + +QI+K + + ED++ D+ LS + +++ + + + N+
Sbjct: 294 IQV----------LQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD-ILRREQEQLNVE 342
Query: 284 RCWTLTEAEKMSFETQK--------TNLATENQYLRVSLEKEEKALSSLQEELNKLREQI 335
+ + E E + E K ++ TE + + E+ LQ+ L+ +I
Sbjct: 343 KRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFR-LQQALSDAENEI 401
Query: 336 RILEDKGTSTELVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTA 395
L L ++N KLK +E +++K ++E L + +LK E E + +TA
Sbjct: 402 MRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEEL--QMSLLKLNNEYEVIKSTA 459
Query: 396 LR-----GELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER 450
R EL L L K N +KE I + EL+R Q + +
Sbjct: 460 TRDISLDSELHDLR-LNLEAKEQELNQSISEKETLI--AEIEELDR------QNQEATKH 510
Query: 451 LYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEK 510
+ + KDQ KQ +G + ++ K V + D + TKE + KEK
Sbjct: 511 M-ILIKDQLSKQQNEGDSIISKLKQDLNDEKKR-----VHQLEDDKMDITKE-LDVQKEK 563
Query: 511 IKQAKEAVKE---NLKKFSDSVKSTFRHF-KDTTKNIFDEKGN 549
+ Q++ A+ + +K D V++ K N+ +K N
Sbjct: 564 LIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN 606
Score = 40.4 bits (93), Expect = 0.006
Identities = 67/319 (21%), Positives = 130/319 (40%), Gaps = 41/319 (12%)
Query: 246 LVRKIHEDELNDMKDYLSQCQQEQESFI-DYKSLKENLARCWTLTEAEKMSFETQKTNLA 304
L ++ ED++ ++ D L++ Q+ S + LKE++ + E ++ E ++
Sbjct: 576 LTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQ--NEEELSRIRNELMQSLNQ 633
Query: 305 TENQYLRVSLEKEEKA----LSSLQEELNKLREQIR--ILEDKGTSTELVKENQKLKQHL 358
N + +L KE +A L EL +L E ++ + K + +LV + ++ L
Sbjct: 634 DSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQL 693
Query: 359 EEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVY 418
EE + ++ T++ KM K E+E E E + S++ N+
Sbjct: 694 EECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLN 753
Query: 419 TEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAK 478
T ++ E L +L +K E E K + TD K+ S +
Sbjct: 754 TSALQLE--HEHLIKLNQKKDME----------IAELKKNIEQMDTDHKETKDVLSSSLE 801
Query: 479 NKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKD 538
+ + T L + KE F EK+K+ ++E L K+S +++ +
Sbjct: 802 EQKQLTQLINKKEIF--------------IEKLKERSSKLQEELDKYSQALRK-----NE 842
Query: 539 TTKNIFDEKGNKRFGATKE 557
+ +EK ++ G+ KE
Sbjct: 843 ILRQTIEEK-DRSLGSMKE 860
Score = 38.9 bits (89), Expect = 0.018
Identities = 53/231 (22%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 239 QIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFET 298
Q++++Q +++K+ +++ +K Q E+F + + E L + T + + E
Sbjct: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEM 1456
Query: 299 QKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQ-KLKQH 357
L EN+ + + +E +LQE K +R +K +KE +Q
Sbjct: 1457 DIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLR---EKEFECHSMKEKALAFEQL 1513
Query: 358 LEEEKQKKHSFLSQRETLLTEAKMLKRE--------------LERERLVTTALRGELQQL 403
L+E++Q K L+Q LL K ++ + L+++++ TAL+ E+Q+L
Sbjct: 1514 LKEKEQGKTGELNQ---LLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570
Query: 404 SGSQLHGKS----------DSPNVYT------EKKEIAILRERLTELERKL 438
+ +S + YT E +E A LR+++T LE KL
Sbjct: 1571 RDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE-AKLRKKVTVLEEKL 1620
Score = 36.2 bits (82), Expect = 0.12
Identities = 43/176 (24%), Positives = 78/176 (44%), Gaps = 32/176 (18%)
Query: 248 RKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEK----MSFETQK--T 301
R ++ L ++L + Q+++ ++ LK+N+ + T + K S E QK T
Sbjct: 750 RNLNTSALQLEHEHLIKLNQKKD--MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLT 807
Query: 302 NLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEE 361
L + + + +EK ++ S LQEEL+K + +R +N+ L+Q +EE+
Sbjct: 808 QLINKKE---IFIEKLKERSSKLQEELDKYSQALR-------------KNEILRQTIEEK 851
Query: 362 KQKKHSFLSQRETLLTEAKMLKRELERERLV--------TTALRGELQQLSGSQLH 409
+ S + L E + L+ E R V T L E+ QL+ + H
Sbjct: 852 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEH 907
Score = 31.2 bits (69), Expect = 3.7
Identities = 51/271 (18%), Positives = 112/271 (41%), Gaps = 56/271 (20%)
Query: 244 QQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNL 303
+QL+++ + + ++ L+ + QE + ++ ++ + + E + + + L
Sbjct: 1511 EQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570
Query: 304 ATE----NQYLRVS----LEKEE----KALSSLQEELNKLREQIRILEDKGTSTELVKEN 351
+ NQ L LE E+ +AL++ E KLR+++ +LE+K S+ EN
Sbjct: 1571 RDKEFRSNQELERLRNHLLESEDSYTREALAAEDREA-KLRKKVTVLEEKLVSSSNAMEN 1629
Query: 352 QK-------------------------LKQHLEEEKQKKHSF-LSQRETLL-----TEAK 380
L+ + +E+ K+++ L+ + +L E
Sbjct: 1630 ASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKA 1689
Query: 381 MLKRELERERLVTTALRGELQQLSG---------SQLHGKSDSPNVYTEKKEIAILRERL 431
M ELE+++ + + + L G + + DS + TE ++ + E++
Sbjct: 1690 MYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTE--QLDVKEEQI 1747
Query: 432 TELERKLTFEQQR-SDLWERLYVEAKDQNGK 461
EL+R+ Q+ D+ ++L A GK
Sbjct: 1748 EELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2102
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2340
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQ 2362
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1515
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1574
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1575 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1621
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1672
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2065
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2066 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2122
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2123 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2172 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2222
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2370
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2486
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2543
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2534
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2535 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2593 RLREQLQLLEEQHRAALAHSE 2613
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1385 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1443 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1488
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1598
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1719 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1759
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSK 1786
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 670 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 729
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 730 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2106
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2166
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2226
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2344
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQ 2366
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1519
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1578
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1579 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1625
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1676
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 2015 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2069
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2070 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2126
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2127 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2176 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2226
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2374
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2490
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2491 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2547
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2482 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2538
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2539 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2596
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2597 RLREQLQLLEEQHRAALAHSE 2617
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1389 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1447 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1492
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1602
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1723 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1763
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSK 1790
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 674 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 733
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 734 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 790
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2102
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2162
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2222
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2340
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQ 2362
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1515
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1574
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1575 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1621
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1672
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 2011 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2065
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2066 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2122
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2123 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2172 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2222
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2370
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2486
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2487 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2543
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2534
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2535 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2593 RLREQLQLLEEQHRAALAHSE 2613
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1385 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1443 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1488
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1598
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1719 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1759
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSK 1786
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 670 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 729
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 730 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2070
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2130
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2190
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2308
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQ 2330
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1483
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1542
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1543 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1589
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1640
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 1979 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2033
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2034 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2090
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2091 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2140 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2190
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2338
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2454
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2455 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2511
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2446 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2502
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2503 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2560
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2561 RLREQLQLLEEQHRAALAHSE 2581
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1353 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1411 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1456
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1566
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1687 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1727
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSK 1754
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 638 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 697
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 698 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 754
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2239
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2359
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2477
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQ 2499
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1652
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1711
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1712 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1758
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1809
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2202
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2203 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2259
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2260 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2309 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2359
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2507
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2623
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2624 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2680
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2615 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2671
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2672 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2729
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2730 RLREQLQLLEEQHRAALAHSE 2750
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1522 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1580 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1625
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1735
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1856 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1896
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSK 1923
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 807 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 866
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 867 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2080
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2200
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2318
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQ 2340
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1493
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1552
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1553 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1599
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1650
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2043
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2044 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2100
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2101 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2150 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2200
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2348
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2464
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2465 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2521
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2456 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2512
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2513 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2570
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2571 RLREQLQLLEEQHRAALAHSE 2591
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1363 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1421 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1466
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1576
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1697 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1737
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSK 1764
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 648 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 707
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 708 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 764
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2030 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2088
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2148
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2208
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2326
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQ 2348
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1382
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1501
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1560
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1561 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1607
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1658
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1996
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 1997 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2051
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2052 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2108
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2109 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2158 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2208
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2356
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2472
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2473 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2529
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2464 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2520
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2521 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2578
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2579 RLREQLQLLEEQHRAALAHSE 2599
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1371 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1428
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1429 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1474
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1535 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1584
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1705 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1745
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSK 1772
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 656 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 715
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 716 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 772
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 54.7 bits (130), Expect = 3e-07
Identities = 65/322 (20%), Positives = 130/322 (40%), Gaps = 24/322 (7%)
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQK 300
QKR Q K H + + L Q Q+++S +D + AR EAE+ + ++
Sbjct: 2071 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR-AAEEAEEARVQAER 2129
Query: 301 TNLATENQY-----LRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLK 355
+ Q L+ S E++ +A + Q KLR++ + E QK
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2189
Query: 356 QHLEEEKQKKHS--FLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSD 413
E EK KK + L Q+ + E L+ +LE L ELQ+L
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ 2249
Query: 414 SPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWER----LYVEAKDQNGKQGTDGKKK 469
V E + + E L++L+ ++ E + L ++ +++ + + KQ + +
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 470 ---GGRGSHRAKNKSKETFLGS-------VKETFDAMKNSTKEFVRHHKEKIKQAKEAVK 519
+ + R + ++E +KE A++ +T+ ++ E ++Q KE +
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQQKELAQ 2367
Query: 520 ENLKKFSDSVKSTFRHFKDTTK 541
E ++ + + + + T+
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQ 2389
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/356 (22%), Positives = 146/356 (41%), Gaps = 40/356 (11%)
Query: 183 KTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGT-IQIQ 241
+T+ E E+RL +Q E + L+ + + L K LA A + +Q +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1423
Query: 242 KRQQLVRKIH-----EDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM-- 294
++++VR+ + + +++ L Q +Q E+ I K+ + A L E++
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 295 ------SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELV 348
+ E Q+ E Q LR E+ E QEE +LR Q++ + E V
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE-V 1542
Query: 349 KENQKLKQHLEEEKQKKHSFLSQRETLL----TEAKMLKRELERERLVTTALRGELQQLS 404
+ ++K E ++K+ + + E L E ++ + E+ER R V AL Q+ +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE-TAQRSA 1601
Query: 405 GSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGT 464
++L K A E+ +LER L E+ + R E + Q +
Sbjct: 1602 EAELQSKR------------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1648
Query: 465 DGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKE 520
+++ R R + K+ E ++ A + S + E KQ +EA +E
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ-----AEAEKQKEEAERE 1699
Score = 47.0 bits (110), Expect = 7e-05
Identities = 82/360 (22%), Positives = 142/360 (39%), Gaps = 66/360 (18%)
Query: 240 IQKRQQLVRKIHEDELNDMK----DYLSQCQQEQESFIDYKS-----------LKENLAR 284
I++R +RK + EL K D L Q +Q +E + K+ L+ L R
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Query: 285 CWTLTEAEKMSFETQKTNLATENQYL----RVSLEKEEKALSSLQEELNKLREQIRILED 340
+ E S E + A + Q R E EE+ SL E R++ LE+
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2037
Query: 341 KGTSTELVKENQKLKQHLEEE------------------KQKKHSFLSQRETLLTEAKML 382
V+E ++L++ E+E ++K H+F Q+ + + L
Sbjct: 2038 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ-----KEQEL 2092
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELER-KLTFE 441
++ L++E+ V LRGE + + + +++ V E +E A R ++ E ER K + E
Sbjct: 2093 QQTLQQEQSVLDQLRGEAE--AARRAAEEAEEARVQAE-REAAQSRRQVEEAERLKQSAE 2149
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETFDAMKNSTK 501
+Q A+ + Q K + A+ E K+ DA K
Sbjct: 2150 EQ-----------AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198
Query: 502 EFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEK 561
+F E+ + K V++ L ++ T D KN+ DE+ + EAA +
Sbjct: 2199 KFA----EQTLRQKAQVEQELTTLRLQLEET-----DHQKNLLDEELQRLKAEATEAARQ 2249
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 36/290 (12%)
Query: 182 KKTVSASESEDRLVAEQET-EPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYGTIQI 240
K+ + A + RL AE E + KEL++ Q +A +A F T++
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ--GFQRTLEA 2397
Query: 241 QKRQQLVRKIHEDELNDMKDYLSQCQ-QEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
++++QL + L +S+ Q + +E ++ E + TE T
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 300 KTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLE 359
L + Q E+ +A++ L+ E KL+++ ++L+ K + V++ Q L +
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----Q 2513
Query: 360 EEKQKKHSFLSQRETLL---------------------TEAKMLKRELERERLVTTALRG 398
E + + SFLS++++LL +A+ L+ E +R++ +
Sbjct: 2514 ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ---QQMEQ 2570
Query: 399 ELQQLSGSQLHGK----SDSPNVYTEKKEIAILRERLTELERKLTFEQQR 444
E Q+L S + V +++E+ L ++ + E L E QR
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/141 (23%), Positives = 73/141 (51%), Gaps = 9/141 (6%)
Query: 237 TIQIQKRQQLVRKIHEDELNDMKDYLSQCQQ--EQESFIDYKSLKENLARCWTLTEAEKM 294
T+Q ++ Q + + + L++ KD L Q ++ EQE + ++ +A+ L E +
Sbjct: 2505 TVQQEQLLQETQALQQSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-- 2561
Query: 295 SFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTE--LVKENQ 352
+ Q+ + E Q L S+E+ + +E + + +E+++ LE + E L +ENQ
Sbjct: 2562 --QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2619
Query: 353 KLKQHLEEEKQKKHSFLSQRE 373
+L++ L+ +++ + L+ E
Sbjct: 2620 RLREQLQLLEEQHRAALAHSE 2640
Score = 38.5 bits (88), Expect = 0.023
Identities = 89/447 (19%), Positives = 170/447 (38%), Gaps = 69/447 (15%)
Query: 47 QEELQALQIEQGESSQNGTVLMEETAYPALEETSSTIEAEEQKIPEDSIYIGTASDDSDI 106
Q E +A +++Q Q V EE A A ++ S E +Q I + ++
Sbjct: 1412 QAEREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1469
Query: 107 VTLEPPKLEEIGNQEVVIVE-EAQSSEDFNMGSSSSSQYTFCQPETVFSSQPSDDESSSD 165
++EE E+ +V + +++E G+ Q + E E+ +
Sbjct: 1470 AERSRLRIEE----EIRVVRLQLEATERQRGGAEGELQALRARAE----------EAEAQ 1515
Query: 166 ETSNQPSPAFRRRRARKKTVSASESEDRLVAEQETEPSKELSKRQFSSGLNKCVILALVI 225
+ Q RR+ + ++ ++E L + + E K++ L + + A
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575
Query: 226 AISMGFGHFYGTIQIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESF------IDYKSLK 279
+ Q+Q + ++ E EL Q ++ SF ++ +
Sbjct: 1576 ERRLRQAEVERARQVQVALETAQRSAEAEL----------QSKRASFAEKTAQLERSLQE 1625
Query: 280 ENLARCWTLTEAEKMSFETQKTNLATE-------------NQYLRVSLEKEEKA--LSSL 324
E++A EAE+ + + + A E N+ LR+ L+ EE A S
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 325 QEELNKLREQI-RILEDKGTSTE-LVKENQKLKQHLEEEKQKKHSFLSQRETLLTEAKML 382
Q E K +E+ R +G + E V++ + +Q LE+++Q QR E L
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745
Query: 383 KRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFEQ 442
+ E E+ L EL +L ++E A ++ ELE +L +
Sbjct: 1746 RAETEQGEQQRQLLEEELARL-----------------QREAAAATQKRQELEAELA--K 1786
Query: 443 QRSDLWERLYVEAKDQNGKQGTDGKKK 469
R+++ L +A+ + + T K K
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSK 1813
Score = 30.0 bits (66), Expect = 8.3
Identities = 26/117 (22%), Positives = 49/117 (41%), Gaps = 14/117 (11%)
Query: 182 KKTVSASESEDRLVAEQE-----TEPSKELSKRQFSSGLNKCVILALVIAISMGFGHFYG 236
KK + DRL+ E E + + Q+S L C + + + + F+
Sbjct: 697 KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 756
Query: 237 TI-----QIQKRQQLVRKIHEDE----LNDMKDYLSQCQQEQESFIDYKSLKENLAR 284
+ Q+QK Q+ +R+ + + + ++D L Q E+E +YK LA+
Sbjct: 757 DVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 813
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 54.3 bits (129), Expect = 4e-07
Identities = 54/289 (18%), Positives = 133/289 (46%), Gaps = 19/289 (6%)
Query: 239 QIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFET 298
Q +K Q+ + E E + + + +++E + + ++E + W E
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLWEQEKMQEQEEKIWEQEE----KIRD 522
Query: 299 QKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHL 358
Q+ E + R +E++ QEE K+R+Q + + D+ E + Q+ K
Sbjct: 523 QEEMWGQEKKMWRQEKMREQEDQMWEQEE--KMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 359 EEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVY 418
+EEK ++ + +RE + E + + RE E + ++ + +++ + +
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEK------MQEQEEKMQEQEEKMWEQEEKMQ 634
Query: 419 TEKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAK 478
+++++ E++ E E K+ +Q+ + E+L+ K Q ++ + ++K + +
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE-QEKME 693
Query: 479 NKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSD 527
K++E K+T+D K +E +R ++K+++ +E ++E +K +
Sbjct: 694 KKTQE----QEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738
Score = 48.1 bits (113), Expect = 3e-05
Identities = 44/232 (18%), Positives = 101/232 (43%), Gaps = 14/232 (6%)
Query: 268 EQESFIDYKSLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEE 327
E E + + ++E + W + EK + E +K E S+ + EK + +E
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 328 LNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQKKHSFL-SQRETLLTEAKMLKREL 386
+ + E+++ E+K E Q+ K +EEK + L Q+E L KM ++E
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 387 -----ERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTELERKLTFE 441
E+ R +RG+ +++ G + + ++ +++++ E++ E K+ +
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848
Query: 442 QQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKSKETFLGSVKETF 493
+++ +E K Q ++ +++ RG + +E G ++ +
Sbjct: 849 EEK--------MEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKIY 892
Score = 43.1 bits (100), Expect = 0.001
Identities = 56/297 (18%), Positives = 135/297 (45%), Gaps = 22/297 (7%)
Query: 239 QIQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFET 298
Q +K + K+ E E + +QE++ + +++ R W E ++ E
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW---EQDERLREK 409
Query: 299 QKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVK---ENQKLK 355
++ E + +V +EEK +QE+ K R+Q ++++ E K E ++
Sbjct: 410 EERMREQEKMWEQVEKMREEK---KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETM 466
Query: 356 QHLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSP 415
+ EE+ QK+ + ++E + + L ++E+L E ++ Q D
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPE--QKEKLWEQEKMQEQEEKIWEQEEKIRDQE 524
Query: 416 NVYTEKKEI---AILRERLTEL-ERKLTFEQQRSDLWER-LYVEAKDQNGKQGTDGKKKG 470
++ ++K++ +RE+ ++ E++ Q +W++ +E K Q ++ T +++
Sbjct: 525 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
Query: 471 GRGSHRAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSD 527
R R + + K+ ++E + M+ +E ++ +EK+++ +E + E +K +
Sbjct: 585 MREEERMREREKK-----MREEEEMMREQ-EEKMQEQEEKMQEQEEKMWEQEEKMQE 635
Score = 39.3 bits (90), Expect = 0.014
Identities = 57/317 (17%), Positives = 133/317 (41%), Gaps = 37/317 (11%)
Query: 266 QQEQESFIDYKSLKENLARCWTLTEA---EKMSFETQKTNLATENQYLRVS---LEKEEK 319
+QE+E K +++ + W E ++ Q+ + + + LR L ++EK
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEK 335
Query: 320 ALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEE---------KQKKHSFLS 370
L Q+EL + EQ++ E+K E Q+ K +EE ++++
Sbjct: 336 ELRE-QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD 394
Query: 371 QRETLLTEAKMLKRELER-----------ERLVTTALRGELQQLSGSQLHGKSDSPNVYT 419
Q E + + + L+ + ER E++ E ++ + Q + +
Sbjct: 395 QEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE 454
Query: 420 EKKEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKN 479
+K++ E + E E K+ ++Q ++WE+ E K+ ++ + K+K +
Sbjct: 455 REKKMREEEETMREQEEKM--QKQEENMWEQ---EEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Query: 480 KSK----ETFLGSVKETFDAMKNS-TKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFR 534
+ K E + +E + K +E +R ++++ + +E +++ +K D + +
Sbjct: 510 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Query: 535 HFKDTTKNIFDEKGNKR 551
++ K +D++ R
Sbjct: 570 KTQEQEKKTWDQEEKMR 586
Score = 38.5 bits (88), Expect = 0.023
Identities = 51/233 (21%), Positives = 102/233 (43%), Gaps = 35/233 (15%)
Query: 302 NLATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEE 361
+ A E Q ++ K EEL K R+ + + + T T N++LK+ E
Sbjct: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTIT-----NEELKKKNAEL 230
Query: 362 KQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEK 421
++K S++ + K LKR+LER + + L Q+ + L +
Sbjct: 231 QEKLPLAESEKSEIQLNVKELKRKLERAKFL-------LPQVQTNTL------------Q 271
Query: 422 KEIAILRERLTELERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSHRAKNKS 481
+E+ E L E E+K+ +Q +W R ++Q GK + ++K R R + +
Sbjct: 272 EEMWRQEEELREQEKKI--RKQEEKMW-RQEERLREQEGKM-REQEEKMWRQEKRLREQE 327
Query: 482 KETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFR 534
KE ++E ++ + +R +E++++ +E + E +K + + +R
Sbjct: 328 KE-----LREQEKELREQKE--LREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/317 (20%), Positives = 135/317 (42%), Gaps = 23/317 (7%)
Query: 240 IQKRQQLVRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKMSFETQ 299
+Q +Q R H E+ ++ L + +E+E+ ++ K + A L E E + Q
Sbjct: 631 LQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ 690
Query: 300 KTNLAT-ENQYLRVSLEKEEKALSSLQEELNKLREQIRILED-KGTSTELVKENQKLKQH 357
+ + E + L+ ++ K + + +L E++ L+ + S+E E +KL+Q
Sbjct: 691 EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ 750
Query: 358 LE-EEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPN 416
LE EKQ KH + ++ ++A + REL+ L T L+ L ++S +
Sbjct: 751 LEAAEKQIKHLEI-EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK--------- 800
Query: 417 VYTEKKEIAILRERLTEL-ERKLTFEQQRSDLWERLYVEAKDQNGKQGTDGKKKGGRGSH 475
T +KE+ IL+E+ E E ++ ++ + +L+ + + N K +
Sbjct: 801 -ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM 859
Query: 476 RAKNKSKETFLGSVKETFDAMKNSTKEFVRHHKEKIKQAKEAVKENLKKFSDSVKSTFRH 535
AK + K+ + + + ++N E ++ + Q L K +D ++ R
Sbjct: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ--------LTKMNDELRLKERD 911
Query: 536 FKDTTKNIFDEKGNKRF 552
++ + N F
Sbjct: 912 VEELQLKLTKANENASF 928
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/212 (28%), Positives = 91/212 (42%), Gaps = 31/212 (14%)
Query: 255 LNDMKDYLSQCQQEQESFIDYKSLKEN-LARCWTLTEA-EKMSFETQKTN-LATENQYLR 311
L D K ++ Q E ++ LKEN L L ++ E ++ E QK E + L+
Sbjct: 1063 LEDTKQTNAKLQNELDT------LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1116
Query: 312 VSLEKEEKALSSLQEELNKLREQIRILEDKGTS---------------TELVKENQKLKQ 356
+ ++ + LS+LQEE KL E++ D+ TS E+ K K +
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1176
Query: 357 HLEEEKQKKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPN 416
+EEK +S LLTE ELE+ R T LRGE S LH +
Sbjct: 1177 DADEEKASLQKSISITSALLTEK---DAELEKLRNEVTVLRGE--NASAKSLHSVVQTLE 1231
Query: 417 VYTEKKEIAI--LRERLTELERKLTFEQQRSD 446
K E+ + L +L E +R+L+ +D
Sbjct: 1232 SDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1263
Score = 43.5 bits (101), Expect = 7e-04
Identities = 79/384 (20%), Positives = 147/384 (38%), Gaps = 60/384 (15%)
Query: 247 VRKIHEDELNDMKDYLSQCQQEQESFIDYKSLKENLARCWTLTEAEKM---SFETQKTNL 303
V++ E EL +K+ ++ +E S +S++E + + E M E + NL
Sbjct: 799 VKETLEKELQILKEKFAEASEEAVSV--QRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
Query: 304 ATENQYLRVSLEKEEKALSSLQEELNKLREQIRILEDKGTSTELVKENQKLKQHLEEEKQ 363
A R E+EE+ + + ++ N + E +++ D + + + +LK+ EE Q
Sbjct: 857 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 916
Query: 364 KKHSFLSQRETLLTEAKMLKRELERERLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKE 423
K + ++ A L++ +E ++ E Q ++ H + EKKE
Sbjct: 917 LKLTKANE------NASFLQKSIE-----DMTVKAEQSQQEAAKKHEE--------EKKE 957
Query: 424 IAILRERLTELERKL-TFEQQRSDL---WERLYVEAKD---------QNGKQGTDGKKKG 470
L +L++LE+K+ T Q +L +ER E K Q T+ K KG
Sbjct: 958 ---LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1014
Query: 471 GRGSHRA---------KNKSKETFLGSVKETFDAMKNSTK---------EFVRHHKEKIK 512
R + K K + ++ M+ TK E + K++
Sbjct: 1015 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074
Query: 513 QAKEAVKENLKKFSDSVKSTFRHFKDTTKNIFDEKGNKRFGATKEAAEKPRTVFSDYLHP 572
+ +KEN K + + + T +N E+ K K+AA + S
Sbjct: 1075 NELDTLKENNLKNVEELNKSKELL--TVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132
Query: 573 QYKAPTENHHNRGPTMQNDGRKEK 596
K E +R + +E+
Sbjct: 1133 NVKLAEELGRSRDEVTSHQKLEEE 1156
Score = 34.7 bits (78), Expect = 0.34
Identities = 65/269 (24%), Positives = 117/269 (43%), Gaps = 32/269 (11%)
Query: 277 SLKENLARCWTLTEAEKMSFETQKTNLATENQYLRVSLEKEEKALSSLQEELNKLREQIR 336
SL + ++ E + + + T+L + +KE KAL + E+L+K E ++
Sbjct: 501 SLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK 560
Query: 337 I-LE--DKGTSTELVKENQKLK----QHLEEEKQKKHSFLSQRETLLTEAKMLKRELERE 389
LE +K S + KL+ H + ++ K SF T E LK ++E+
Sbjct: 561 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM 620
Query: 390 RLVTTALRGELQQLSGSQLHGKSDSPNVYTEKKEIAILRERLTEL--ERKLTFEQQRSDL 447
RL + E++ L Q DS KE+ LR +L ++ E++ + E RS L
Sbjct: 621 RL---DYQHEIENLQNQQ-----DSERA-AHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671
Query: 448 ---WERLYVEAKDQ-NGKQGTDGKKKG---GRGSHRAKNKSKETFLGSVKET------FD 494
++ VE +D N Q + K K + + K + F +K T D
Sbjct: 672 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 731
Query: 495 AMKNSTKEFVRHHKEKIKQAKEAVKENLK 523
A++ ++ E + +K++Q EA ++ +K
Sbjct: 732 ALRKASSE-GKSEMKKLRQQLEAAEKQIK 759
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,584,585
Number of Sequences: 37866
Number of extensions: 1360037
Number of successful extensions: 11380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 992
Number of HSP's that attempted gapping in prelim test: 7043
Number of HSP's gapped (non-prelim): 3603
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.