Search of human proteins with 7305053

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7305053 myoferlin isoform a [Homo sapiens]
         (2061 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7305053 myoferlin isoform a [Homo sapiens]                        4224   0.0  
gi|19718759 myoferlin isoform b [Homo sapiens]                       4189   0.0  
gi|195976821 dysferlin isoform 2 [Homo sapiens]                      2384   0.0  
gi|195976769 dysferlin isoform 6 [Homo sapiens]                      2381   0.0  
gi|195976777 dysferlin isoform 3 [Homo sapiens]                      2380   0.0  
gi|4503431 dysferlin isoform 8 [Homo sapiens]                        2379   0.0  
gi|195976773 dysferlin isoform 5 [Homo sapiens]                      2377   0.0  
gi|195976766 dysferlin isoform 7 [Homo sapiens]                      2376   0.0  
gi|195976758 dysferlin isoform 11 [Homo sapiens]                     2376   0.0  
gi|195976754 dysferlin isoform 9 [Homo sapiens]                      2375   0.0  
gi|195976775 dysferlin isoform 4 [Homo sapiens]                      2372   0.0  
gi|195976756 dysferlin isoform 10 [Homo sapiens]                     2372   0.0  
gi|195976760 dysferlin isoform 12 [Homo sapiens]                     2370   0.0  
gi|195976779 dysferlin isoform 1 [Homo sapiens]                      2369   0.0  
gi|195976762 dysferlin isoform 13 [Homo sapiens]                     2367   0.0  
gi|195976764 dysferlin isoform 14 [Homo sapiens]                     2363   0.0  
gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]                   1528   0.0  
gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]                    718   0.0  
gi|119120884 fer-1-like 6 [Homo sapiens]                              689   0.0  
gi|35493868 otoferlin isoform b [Homo sapiens]                        688   0.0  
gi|35493853 otoferlin isoform c [Homo sapiens]                        684   0.0  
gi|34740331 otoferlin isoform a [Homo sapiens]                        684   0.0  
gi|35493860 otoferlin isoform d [Homo sapiens]                        681   0.0  
gi|238550198 synaptotagmin III [Homo sapiens]                          62   6e-09
gi|238550196 synaptotagmin III [Homo sapiens]                          62   6e-09
gi|14150054 synaptotagmin III [Homo sapiens]                           62   6e-09
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    60   3e-08
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    60   3e-08
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    57   2e-07
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    57   2e-07

>gi|7305053 myoferlin isoform a [Homo sapiens]
          Length = 2061

 Score = 4224 bits (10954), Expect = 0.0
 Identities = 2061/2061 (100%), Positives = 2061/2061 (100%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD
Sbjct: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
            FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL
Sbjct: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120

Query: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180
            VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR
Sbjct: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180

Query: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240
            RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF
Sbjct: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240

Query: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300
            FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL
Sbjct: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300

Query: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360
            LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF
Sbjct: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360

Query: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420
            LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE
Sbjct: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420

Query: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTG 480
            WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTG
Sbjct: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTG 480

Query: 481  AASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 540
            AASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE
Sbjct: 481  AASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 540

Query: 541  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 600
            LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG
Sbjct: 541  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 600

Query: 601  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 660
            NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL
Sbjct: 601  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 660

Query: 661  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 720
            LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT
Sbjct: 661  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 720

Query: 721  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 780
            QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI
Sbjct: 721  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 780

Query: 781  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 840
            RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL
Sbjct: 781  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 840

Query: 841  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 900
            GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL
Sbjct: 841  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 900

Query: 901  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 960
            PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK
Sbjct: 901  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 960

Query: 961  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1020
            AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR
Sbjct: 961  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1020

Query: 1021 RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM 1080
            RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM
Sbjct: 1021 RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM 1080

Query: 1081 APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH 1140
            APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH
Sbjct: 1081 APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH 1140

Query: 1141 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1200
            LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE
Sbjct: 1141 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1200

Query: 1201 PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC 1260
            PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC
Sbjct: 1201 PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC 1260

Query: 1261 GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ 1320
            GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ
Sbjct: 1261 GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ 1320

Query: 1321 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH 1380
            MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH
Sbjct: 1321 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH 1380

Query: 1381 RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA 1440
            RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA
Sbjct: 1381 RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA 1440

Query: 1441 SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT 1500
            SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT
Sbjct: 1441 SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT 1500

Query: 1501 FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV 1560
            FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV
Sbjct: 1501 FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV 1560

Query: 1561 RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI 1620
            RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI
Sbjct: 1561 RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI 1620

Query: 1621 SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV 1680
            SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV
Sbjct: 1621 SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV 1680

Query: 1681 ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE 1740
            ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE
Sbjct: 1681 ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE 1740

Query: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800
            HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV
Sbjct: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800

Query: 1801 ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL 1860
            ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL
Sbjct: 1801 ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL 1860

Query: 1861 CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR 1920
            CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR
Sbjct: 1861 CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR 1920

Query: 1921 LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE 1980
            LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE
Sbjct: 1921 LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE 1980

Query: 1981 RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF 2040
            RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF
Sbjct: 1981 RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF 2040

Query: 2041 VAVLLYSLPNYLSMKIVKPNV 2061
            VAVLLYSLPNYLSMKIVKPNV
Sbjct: 2041 VAVLLYSLPNYLSMKIVKPNV 2061


>gi|19718759 myoferlin isoform b [Homo sapiens]
          Length = 2048

 Score = 4189 bits (10865), Expect = 0.0
 Identities = 2048/2061 (99%), Positives = 2048/2061 (99%), Gaps = 13/2061 (0%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD
Sbjct: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
            FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL
Sbjct: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120

Query: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180
            VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR
Sbjct: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180

Query: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240
            RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF
Sbjct: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240

Query: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300
            FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL
Sbjct: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300

Query: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360
            LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF
Sbjct: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360

Query: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420
            LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE
Sbjct: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420

Query: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTG 480
            WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVE        
Sbjct: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVE-------- 472

Query: 481  AASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 540
                 VNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE
Sbjct: 473  -----VNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 527

Query: 541  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 600
            LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG
Sbjct: 528  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 587

Query: 601  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 660
            NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL
Sbjct: 588  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 647

Query: 661  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 720
            LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT
Sbjct: 648  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 707

Query: 721  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 780
            QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI
Sbjct: 708  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 767

Query: 781  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 840
            RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL
Sbjct: 768  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 827

Query: 841  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 900
            GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL
Sbjct: 828  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 887

Query: 901  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 960
            PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK
Sbjct: 888  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 947

Query: 961  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1020
            AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR
Sbjct: 948  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1007

Query: 1021 RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM 1080
            RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM
Sbjct: 1008 RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM 1067

Query: 1081 APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH 1140
            APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH
Sbjct: 1068 APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH 1127

Query: 1141 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1200
            LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE
Sbjct: 1128 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1187

Query: 1201 PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC 1260
            PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC
Sbjct: 1188 PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC 1247

Query: 1261 GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ 1320
            GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ
Sbjct: 1248 GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ 1307

Query: 1321 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH 1380
            MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH
Sbjct: 1308 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH 1367

Query: 1381 RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA 1440
            RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA
Sbjct: 1368 RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA 1427

Query: 1441 SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT 1500
            SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT
Sbjct: 1428 SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT 1487

Query: 1501 FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV 1560
            FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV
Sbjct: 1488 FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV 1547

Query: 1561 RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI 1620
            RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI
Sbjct: 1548 RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI 1607

Query: 1621 SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV 1680
            SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV
Sbjct: 1608 SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV 1667

Query: 1681 ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE 1740
            ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE
Sbjct: 1668 ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE 1727

Query: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800
            HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV
Sbjct: 1728 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1787

Query: 1801 ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL 1860
            ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL
Sbjct: 1788 ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL 1847

Query: 1861 CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR 1920
            CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR
Sbjct: 1848 CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR 1907

Query: 1921 LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE 1980
            LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE
Sbjct: 1908 LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE 1967

Query: 1981 RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF 2040
            RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF
Sbjct: 1968 RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF 2027

Query: 2041 VAVLLYSLPNYLSMKIVKPNV 2061
            VAVLLYSLPNYLSMKIVKPNV
Sbjct: 2028 VAVLLYSLPNYLSMKIVKPNV 2048


>gi|195976821 dysferlin isoform 2 [Homo sapiens]
          Length = 2081

 Score = 2384 bits (6179), Expect = 0.0
 Identities = 1179/2109 (55%), Positives = 1518/2109 (71%), Gaps = 80/2109 (3%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFP 517
            YL +SKI+A GGE+E+  +     +    +  +  +GF+PTFGPCY+NLYGSPRE+TGFP
Sbjct: 480  YLSMSKISAPGGEIEEEPAGAVKPSK--ASDLDDYLGFLPTFGPCYINLYGSPREFTGFP 537

Query: 518  DPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLS 577
            DPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL 
Sbjct: 538  DPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLF 596

Query: 578  AVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHT 637
            A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + 
Sbjct: 597  AAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNV 656

Query: 638  KPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDE 697
            KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE
Sbjct: 657  KPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDE 716

Query: 698  VIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDW 757
            +I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDW
Sbjct: 717  LIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDW 776

Query: 758  LDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIF 817
            L +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIF
Sbjct: 777  LLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIF 836

Query: 818  LKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWG 875
            LKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WG
Sbjct: 837  LKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWG 896

Query: 876  TSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVY 935
            T+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV+
Sbjct: 897  TTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVF 955

Query: 936  QNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEY 995
            +N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY
Sbjct: 956  ENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEY 1015

Query: 996  GITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYAS 1055
             ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYAS
Sbjct: 1016 SITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYAS 1074

Query: 1056 LIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQK 1115
            L GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E   
Sbjct: 1075 LFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSM 1129

Query: 1116 HSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTT 1175
              +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T
Sbjct: 1130 SVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKT 1189

Query: 1176 EIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPV 1235
             ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P 
Sbjct: 1190 VVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP- 1248

Query: 1236 VKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK--------------------- 1274
                  ++  P+L W P+  G +  G++L + ELI R K                     
Sbjct: 1249 -----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES 1303

Query: 1275 DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECG 1334
            + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECG
Sbjct: 1304 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG 1363

Query: 1335 GERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTI 1394
            G+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI
Sbjct: 1364 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI 1423

Query: 1395 ERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIV 1451
              L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+      +EEE +
Sbjct: 1424 RSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFI 1476

Query: 1452 DWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DE 1510
            DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E
Sbjct: 1477 DWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE 1536

Query: 1511 NEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDN 1570
             EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D 
Sbjct: 1537 TEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDP 1596

Query: 1571 NGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTR 1630
            NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++
Sbjct: 1597 NGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSK 1656

Query: 1631 DEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPI 1690
            DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+
Sbjct: 1657 DEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPV 1716

Query: 1691 LSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHST 1750
               D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S 
Sbjct: 1717 YRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSP 1774

Query: 1751 FQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGE 1810
             QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE
Sbjct: 1775 LQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGE 1834

Query: 1811 EMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFW 1870
            +MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW
Sbjct: 1835 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1894

Query: 1871 SIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAM 1930
             +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A 
Sbjct: 1895 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AF 1952

Query: 1931 NPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEP 1990
            +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEP
Sbjct: 1953 HP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEP 2010

Query: 1991 NMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPN 2050
            NMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PN
Sbjct: 2011 NMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPN 2070

Query: 2051 YLSMKIVKP 2059
            Y +MK+VKP
Sbjct: 2071 YAAMKLVKP 2079


>gi|195976769 dysferlin isoform 6 [Homo sapiens]
          Length = 2102

 Score = 2381 bits (6171), Expect = 0.0
 Identities = 1180/2126 (55%), Positives = 1520/2126 (71%), Gaps = 93/2126 (4%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFP 517
            YL +SKI+A GGE+E+  +     +    +  +  +GF+PTFGPCY+NLYGSPRE+TGFP
Sbjct: 480  YLSMSKISAPGGEIEEEPAGAVKPSK--ASDLDDYLGFLPTFGPCYINLYGSPREFTGFP 537

Query: 518  DPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLS 577
            DPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL 
Sbjct: 538  DPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLF 596

Query: 578  AVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHT 637
            A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + 
Sbjct: 597  AAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNV 656

Query: 638  KPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDE 697
            KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE
Sbjct: 657  KPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDE 716

Query: 698  VIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDW 757
            +I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDW
Sbjct: 717  LIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDW 776

Query: 758  LDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIF 817
            L +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIF
Sbjct: 777  LLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIF 836

Query: 818  LKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWG 875
            LKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WG
Sbjct: 837  LKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWG 896

Query: 876  TSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVY 935
            T+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV+
Sbjct: 897  TTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVF 955

Query: 936  QNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEY 995
            +N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY
Sbjct: 956  ENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEY 1015

Query: 996  GITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYAS 1055
             ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYAS
Sbjct: 1016 SITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYAS 1074

Query: 1056 LIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQK 1115
            L GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E   
Sbjct: 1075 LFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSM 1129

Query: 1116 HSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTT 1175
              +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T
Sbjct: 1130 SVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKT 1189

Query: 1176 EIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPV 1235
             ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P 
Sbjct: 1190 VVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP- 1248

Query: 1236 VKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK--------------------- 1274
                  ++  P+L W P+  G +  G++L + ELI R K                     
Sbjct: 1249 -----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES 1303

Query: 1275 DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECG 1334
            + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECG
Sbjct: 1304 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG 1363

Query: 1335 GERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTI 1394
            G+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI
Sbjct: 1364 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI 1423

Query: 1395 ERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE------ 1445
              L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+  +L +      
Sbjct: 1424 RSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLA 1480

Query: 1446 -----------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGL 1494
                        EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL
Sbjct: 1481 PTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGL 1540

Query: 1495 TDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQEC 1553
            +DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC
Sbjct: 1541 SDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQEC 1600

Query: 1554 TVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1613
             VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP
Sbjct: 1601 LVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLP 1660

Query: 1614 QEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRP 1673
             EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP
Sbjct: 1661 LEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRP 1720

Query: 1674 TQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILR 1733
            +QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+
Sbjct: 1721 SQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQ 1778

Query: 1734 TQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVI 1793
             QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR I
Sbjct: 1779 QQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCI 1838

Query: 1794 IWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFD 1853
            IWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFD
Sbjct: 1839 IWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFD 1898

Query: 1854 YLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPA 1913
            YLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PA
Sbjct: 1899 YLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPA 1958

Query: 1914 KSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEIL 1973
            K+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+
Sbjct: 1959 KTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIV 2014

Query: 1974 NEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLF 2033
             E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + 
Sbjct: 2015 AESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFII 2074

Query: 2034 LLILLLFVAVLLYSLPNYLSMKIVKP 2059
            L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2075 LFILLLFLAIFIYAFPNYAAMKLVKP 2100


>gi|195976777 dysferlin isoform 3 [Homo sapiens]
          Length = 2067

 Score = 2380 bits (6169), Expect = 0.0
 Identities = 1179/2109 (55%), Positives = 1514/2109 (71%), Gaps = 94/2109 (4%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFP 517
            YL +SKI+A GGE+E                 +  +GF+PTFGPCY+NLYGSPRE+TGFP
Sbjct: 480  YLSMSKISAPGGEIE----------------VDDYLGFLPTFGPCYINLYGSPREFTGFP 523

Query: 518  DPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLS 577
            DPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL 
Sbjct: 524  DPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLF 582

Query: 578  AVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHT 637
            A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + 
Sbjct: 583  AAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNV 642

Query: 638  KPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDE 697
            KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE
Sbjct: 643  KPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDE 702

Query: 698  VIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDW 757
            +I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDW
Sbjct: 703  LIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDW 762

Query: 758  LDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIF 817
            L +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIF
Sbjct: 763  LLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIF 822

Query: 818  LKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWG 875
            LKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WG
Sbjct: 823  LKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWG 882

Query: 876  TSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVY 935
            T+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV+
Sbjct: 883  TTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVF 941

Query: 936  QNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEY 995
            +N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY
Sbjct: 942  ENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEY 1001

Query: 996  GITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYAS 1055
             ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYAS
Sbjct: 1002 SITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYAS 1060

Query: 1056 LIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQK 1115
            L GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E   
Sbjct: 1061 LFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSM 1115

Query: 1116 HSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTT 1175
              +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T
Sbjct: 1116 SVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKT 1175

Query: 1176 EIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPV 1235
             ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P 
Sbjct: 1176 VVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP- 1234

Query: 1236 VKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK--------------------- 1274
                  ++  P+L W P+  G +  G++L + ELI R K                     
Sbjct: 1235 -----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES 1289

Query: 1275 DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECG 1334
            + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECG
Sbjct: 1290 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG 1349

Query: 1335 GERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTI 1394
            G+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI
Sbjct: 1350 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI 1409

Query: 1395 ERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIV 1451
              L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+      +EEE +
Sbjct: 1410 RSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFI 1462

Query: 1452 DWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DE 1510
            DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E
Sbjct: 1463 DWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEE 1522

Query: 1511 NEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDN 1570
             EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D 
Sbjct: 1523 TEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDP 1582

Query: 1571 NGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTR 1630
            NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++
Sbjct: 1583 NGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSK 1642

Query: 1631 DEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPI 1690
            DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+
Sbjct: 1643 DEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPV 1702

Query: 1691 LSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHST 1750
               D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S 
Sbjct: 1703 YRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSP 1760

Query: 1751 FQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGE 1810
             QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE
Sbjct: 1761 LQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGE 1820

Query: 1811 EMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFW 1870
            +MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW
Sbjct: 1821 KMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFW 1880

Query: 1871 SIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAM 1930
             +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A 
Sbjct: 1881 RLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AF 1938

Query: 1931 NPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEP 1990
            +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEP
Sbjct: 1939 HP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEP 1996

Query: 1991 NMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPN 2050
            NMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PN
Sbjct: 1997 NMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPN 2056

Query: 2051 YLSMKIVKP 2059
            Y +MK+VKP
Sbjct: 2057 YAAMKLVKP 2065


>gi|4503431 dysferlin isoform 8 [Homo sapiens]
          Length = 2080

 Score = 2379 bits (6165), Expect = 0.0
 Identities = 1177/2108 (55%), Positives = 1512/2108 (71%), Gaps = 79/2108 (3%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPD 518
            L +SKI+A GGE+E+  +     +    +  +  +GF+PTFGPCY+NLYGSPRE+TGFPD
Sbjct: 480  LSMSKISAPGGEIEEEPAGAVKPSK--ASDLDDYLGFLPTFGPCYINLYGSPREFTGFPD 537

Query: 519  PYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSA 578
            PY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A
Sbjct: 538  PYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFA 596

Query: 579  VFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTK 638
             F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + K
Sbjct: 597  AFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVK 656

Query: 639  PVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEV 698
            PVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+
Sbjct: 657  PVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDEL 716

Query: 699  IEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWL 758
            I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL
Sbjct: 717  IAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWL 776

Query: 759  DKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFL 818
             +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFL
Sbjct: 777  LRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFL 836

Query: 819  KYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGT 876
            KYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT
Sbjct: 837  KYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGT 896

Query: 877  SGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQ 936
            +GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++
Sbjct: 897  TGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFE 955

Query: 937  NESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYG 996
            N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY 
Sbjct: 956  NQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYS 1015

Query: 997  ITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASL 1056
            ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL
Sbjct: 1016 ITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASL 1074

Query: 1057 IGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKH 1116
             GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E    
Sbjct: 1075 FGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMS 1129

Query: 1117 SATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTE 1176
             +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T 
Sbjct: 1130 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1189

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P  
Sbjct: 1190 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP-- 1247

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------D 1275
                 ++  P+L W P+  G +  G++L + ELI R K                     +
Sbjct: 1248 ----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1303

Query: 1276 GSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGG 1335
             ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG
Sbjct: 1304 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1363

Query: 1336 ERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIE 1395
            + V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI 
Sbjct: 1364 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1423

Query: 1396 RLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVD 1452
             L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+      +EEE +D
Sbjct: 1424 SLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFID 1476

Query: 1453 WWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DEN 1511
            WWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E 
Sbjct: 1477 WWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET 1536

Query: 1512 EDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNN 1571
            EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D N
Sbjct: 1537 EDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPN 1596

Query: 1572 GLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRD 1631
            G CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++D
Sbjct: 1597 GKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKD 1656

Query: 1632 EKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPIL 1691
            EK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+ 
Sbjct: 1657 EKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVY 1716

Query: 1692 SEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTF 1751
              D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  
Sbjct: 1717 RTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPL 1774

Query: 1752 QPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEE 1811
            QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+
Sbjct: 1775 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEK 1834

Query: 1812 MSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWS 1871
            MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW 
Sbjct: 1835 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1894

Query: 1872 IDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMN 1931
            +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +
Sbjct: 1895 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFH 1952

Query: 1932 PLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPN 1991
            P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPN
Sbjct: 1953 P--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPN 2010

Query: 1992 MNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNY 2051
            MNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY
Sbjct: 2011 MNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNY 2070

Query: 2052 LSMKIVKP 2059
             +MK+VKP
Sbjct: 2071 AAMKLVKP 2078


>gi|195976773 dysferlin isoform 5 [Homo sapiens]
          Length = 2088

 Score = 2377 bits (6161), Expect = 0.0
 Identities = 1180/2126 (55%), Positives = 1516/2126 (71%), Gaps = 107/2126 (5%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFP 517
            YL +SKI+A GGE+E                 +  +GF+PTFGPCY+NLYGSPRE+TGFP
Sbjct: 480  YLSMSKISAPGGEIE----------------VDDYLGFLPTFGPCYINLYGSPREFTGFP 523

Query: 518  DPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLS 577
            DPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL 
Sbjct: 524  DPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLF 582

Query: 578  AVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHT 637
            A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + 
Sbjct: 583  AAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNV 642

Query: 638  KPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDE 697
            KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE
Sbjct: 643  KPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDE 702

Query: 698  VIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDW 757
            +I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDW
Sbjct: 703  LIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDW 762

Query: 758  LDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIF 817
            L +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIF
Sbjct: 763  LLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIF 822

Query: 818  LKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWG 875
            LKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WG
Sbjct: 823  LKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWG 882

Query: 876  TSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVY 935
            T+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV+
Sbjct: 883  TTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVF 941

Query: 936  QNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEY 995
            +N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY
Sbjct: 942  ENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEY 1001

Query: 996  GITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYAS 1055
             ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYAS
Sbjct: 1002 SITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYAS 1060

Query: 1056 LIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQK 1115
            L GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E   
Sbjct: 1061 LFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSM 1115

Query: 1116 HSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTT 1175
              +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T
Sbjct: 1116 SVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKT 1175

Query: 1176 EIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPV 1235
             ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P 
Sbjct: 1176 VVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP- 1234

Query: 1236 VKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK--------------------- 1274
                  ++  P+L W P+  G +  G++L + ELI R K                     
Sbjct: 1235 -----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDES 1289

Query: 1275 DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECG 1334
            + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECG
Sbjct: 1290 EDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECG 1349

Query: 1335 GERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTI 1394
            G+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI
Sbjct: 1350 GQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTI 1409

Query: 1395 ERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE------ 1445
              L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+  +L +      
Sbjct: 1410 RSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLA 1466

Query: 1446 -----------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGL 1494
                        EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL
Sbjct: 1467 PTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGL 1526

Query: 1495 TDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQEC 1553
            +DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC
Sbjct: 1527 SDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQEC 1586

Query: 1554 TVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1613
             VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP
Sbjct: 1587 LVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLP 1646

Query: 1614 QEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRP 1673
             EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP
Sbjct: 1647 LEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRP 1706

Query: 1674 TQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILR 1733
            +QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+
Sbjct: 1707 SQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQ 1764

Query: 1734 TQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVI 1793
             QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR I
Sbjct: 1765 QQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCI 1824

Query: 1794 IWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFD 1853
            IWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFD
Sbjct: 1825 IWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFD 1884

Query: 1854 YLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPA 1913
            YLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PA
Sbjct: 1885 YLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPA 1944

Query: 1914 KSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEIL 1973
            K+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+
Sbjct: 1945 KTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIV 2000

Query: 1974 NEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLF 2033
             E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + 
Sbjct: 2001 AESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFII 2060

Query: 2034 LLILLLFVAVLLYSLPNYLSMKIVKP 2059
            L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2061 LFILLLFLAIFIYAFPNYAAMKLVKP 2086


>gi|195976766 dysferlin isoform 7 [Homo sapiens]
          Length = 2112

 Score = 2376 bits (6157), Expect = 0.0
 Identities = 1179/2140 (55%), Positives = 1522/2140 (71%), Gaps = 111/2140 (5%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE----------------- 151
            L + Y P     P  P P  L   P++P +     GG    +                  
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKK 179

Query: 152  --------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVK 186
                    G+ED  D  + G   +       GP    +  +L           +R     
Sbjct: 180  WPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAP 239

Query: 187  NSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFF 246
             SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F
Sbjct: 240  TSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLF 299

Query: 247  YNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPE 306
            +N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+
Sbjct: 300  FNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPD 359

Query: 307  DTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYR 366
            D S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++R
Sbjct: 360  DFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFR 419

Query: 367  AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
            AED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + 
Sbjct: 420  AEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNIT 479

Query: 427  LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTV 486
            L   FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E+  +     +    
Sbjct: 480  LPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSK--A 537

Query: 487  NTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLE 546
            +  +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L 
Sbjct: 538  SDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLV 597

Query: 547  KTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKF 606
            +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKF
Sbjct: 598  E-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKF 656

Query: 607  DTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAER 666
            D TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+R
Sbjct: 657  DMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 716

Query: 667  LQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLR 726
            L+  +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR
Sbjct: 717  LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLR 776

Query: 727  SRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRL 786
            +  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+
Sbjct: 777  THHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRV 836

Query: 787  AYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVE 846
            AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  E
Sbjct: 837  AYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDE 896

Query: 847  KKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKG 904
            K+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  G
Sbjct: 897  KEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAG 955

Query: 905  WEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASP 964
            W W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K    
Sbjct: 956  WTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPK 1015

Query: 965  SELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLV 1024
             ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR V
Sbjct: 1016 DDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWV 1075

Query: 1025 RKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSE 1084
            R R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E
Sbjct: 1076 RLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLE 1134

Query: 1085 THGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCY 1144
              G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY
Sbjct: 1135 KTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCY 1189

Query: 1145 VYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTV 1204
            +YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV
Sbjct: 1190 MYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATV 1249

Query: 1205 LQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVL 1264
             + PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L
Sbjct: 1250 AEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELL 1303

Query: 1265 VTAELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQL 1303
             + ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q 
Sbjct: 1304 ASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQR 1363

Query: 1304 TAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFL 1363
            TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V L
Sbjct: 1364 TAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVML 1423

Query: 1364 PKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLL 1420
            P+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLL
Sbjct: 1424 PREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLL 1482

Query: 1421 SAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKI 1480
            S  P  D++I+++D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+
Sbjct: 1483 S--PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKV 1536

Query: 1481 YNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPP 1539
            Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PP
Sbjct: 1537 YDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPP 1596

Query: 1540 RQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLN 1599
            RQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL 
Sbjct: 1597 RQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLE 1656

Query: 1600 PVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEY 1659
            PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ Y
Sbjct: 1657 PVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTY 1716

Query: 1660 CVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQH 1719
            CVSG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I + H
Sbjct: 1717 CVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPH 1774

Query: 1720 LGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFN 1779
            LG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFN
Sbjct: 1775 LGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFN 1834

Query: 1780 ITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLD 1839
            ITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL 
Sbjct: 1835 ITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLG 1894

Query: 1840 GEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYL 1899
            GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+L
Sbjct: 1895 GEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFL 1954

Query: 1900 GFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGA 1959
            G L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   
Sbjct: 1955 GSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEK 2010

Query: 1960 RVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFI 2019
            +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI
Sbjct: 2011 KILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFI 2070

Query: 2020 VWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2059
            +WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2071 LWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2110


>gi|195976758 dysferlin isoform 11 [Homo sapiens]
          Length = 2101

 Score = 2376 bits (6157), Expect = 0.0
 Identities = 1178/2125 (55%), Positives = 1514/2125 (71%), Gaps = 92/2125 (4%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPD 518
            L +SKI+A GGE+E+  +     +    +  +  +GF+PTFGPCY+NLYGSPRE+TGFPD
Sbjct: 480  LSMSKISAPGGEIEEEPAGAVKPSK--ASDLDDYLGFLPTFGPCYINLYGSPREFTGFPD 537

Query: 519  PYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSA 578
            PY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A
Sbjct: 538  PYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFA 596

Query: 579  VFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTK 638
             F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + K
Sbjct: 597  AFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVK 656

Query: 639  PVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEV 698
            PVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+
Sbjct: 657  PVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDEL 716

Query: 699  IEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWL 758
            I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL
Sbjct: 717  IAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWL 776

Query: 759  DKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFL 818
             +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFL
Sbjct: 777  LRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFL 836

Query: 819  KYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGT 876
            KYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT
Sbjct: 837  KYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGT 896

Query: 877  SGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQ 936
            +GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++
Sbjct: 897  TGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFE 955

Query: 937  NESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYG 996
            N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY 
Sbjct: 956  NQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYS 1015

Query: 997  ITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASL 1056
            ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL
Sbjct: 1016 ITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASL 1074

Query: 1057 IGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKH 1116
             GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E    
Sbjct: 1075 FGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMS 1129

Query: 1117 SATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTE 1176
             +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T 
Sbjct: 1130 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1189

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P  
Sbjct: 1190 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP-- 1247

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------D 1275
                 ++  P+L W P+  G +  G++L + ELI R K                     +
Sbjct: 1248 ----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1303

Query: 1276 GSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGG 1335
             ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG
Sbjct: 1304 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1363

Query: 1336 ERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIE 1395
            + V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI 
Sbjct: 1364 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1423

Query: 1396 RLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE------- 1445
             L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+  +L +       
Sbjct: 1424 SLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLAP 1480

Query: 1446 ----------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLT 1495
                       EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+
Sbjct: 1481 TNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLS 1540

Query: 1496 DFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECT 1554
            DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC 
Sbjct: 1541 DFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECL 1600

Query: 1555 VRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQ 1614
            VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP 
Sbjct: 1601 VRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPL 1660

Query: 1615 EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPT 1674
            EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+
Sbjct: 1661 EKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPS 1720

Query: 1675 QLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRT 1734
            QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ 
Sbjct: 1721 QLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQ 1778

Query: 1735 QGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVII 1794
            QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR II
Sbjct: 1779 QGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCII 1838

Query: 1795 WNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDY 1854
            WNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDY
Sbjct: 1839 WNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDY 1898

Query: 1855 LPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAK 1914
            LPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK
Sbjct: 1899 LPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAK 1958

Query: 1915 SPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILN 1974
            + +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ 
Sbjct: 1959 TAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVA 2014

Query: 1975 EKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFL 2034
            E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L
Sbjct: 2015 ESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIIL 2074

Query: 2035 LILLLFVAVLLYSLPNYLSMKIVKP 2059
             ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2075 FILLLFLAIFIYAFPNYAAMKLVKP 2099


>gi|195976754 dysferlin isoform 9 [Homo sapiens]
          Length = 2066

 Score = 2375 bits (6155), Expect = 0.0
 Identities = 1177/2108 (55%), Positives = 1508/2108 (71%), Gaps = 93/2108 (4%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPD 518
            L +SKI+A GGE+E                 +  +GF+PTFGPCY+NLYGSPRE+TGFPD
Sbjct: 480  LSMSKISAPGGEIE----------------VDDYLGFLPTFGPCYINLYGSPREFTGFPD 523

Query: 519  PYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSA 578
            PY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A
Sbjct: 524  PYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFA 582

Query: 579  VFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTK 638
             F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + K
Sbjct: 583  AFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVK 642

Query: 639  PVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEV 698
            PVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+
Sbjct: 643  PVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDEL 702

Query: 699  IEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWL 758
            I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL
Sbjct: 703  IAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWL 762

Query: 759  DKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFL 818
             +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFL
Sbjct: 763  LRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFL 822

Query: 819  KYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGT 876
            KYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT
Sbjct: 823  KYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGT 882

Query: 877  SGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQ 936
            +GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++
Sbjct: 883  TGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFE 941

Query: 937  NESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYG 996
            N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY 
Sbjct: 942  NQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYS 1001

Query: 997  ITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASL 1056
            ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL
Sbjct: 1002 ITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASL 1060

Query: 1057 IGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKH 1116
             GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E    
Sbjct: 1061 FGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMS 1115

Query: 1117 SATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTE 1176
             +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T 
Sbjct: 1116 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1175

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P  
Sbjct: 1176 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP-- 1233

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------D 1275
                 ++  P+L W P+  G +  G++L + ELI R K                     +
Sbjct: 1234 ----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1289

Query: 1276 GSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGG 1335
             ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG
Sbjct: 1290 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1349

Query: 1336 ERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIE 1395
            + V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI 
Sbjct: 1350 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1409

Query: 1396 RLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVD 1452
             L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+      +EEE +D
Sbjct: 1410 SLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFID 1462

Query: 1453 WWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DEN 1511
            WWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E 
Sbjct: 1463 WWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEET 1522

Query: 1512 EDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNN 1571
            EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D N
Sbjct: 1523 EDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPN 1582

Query: 1572 GLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRD 1631
            G CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++D
Sbjct: 1583 GKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKD 1642

Query: 1632 EKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPIL 1691
            EK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+ 
Sbjct: 1643 EKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVY 1702

Query: 1692 SEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTF 1751
              D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  
Sbjct: 1703 RTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPL 1760

Query: 1752 QPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEE 1811
            QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+
Sbjct: 1761 QPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEK 1820

Query: 1812 MSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWS 1871
            MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW 
Sbjct: 1821 MSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWR 1880

Query: 1872 IDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMN 1931
            +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +
Sbjct: 1881 LDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFH 1938

Query: 1932 PLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPN 1991
            P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPN
Sbjct: 1939 P--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPN 1996

Query: 1992 MNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNY 2051
            MNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY
Sbjct: 1997 MNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNY 2056

Query: 2052 LSMKIVKP 2059
             +MK+VKP
Sbjct: 2057 AAMKLVKP 2064


>gi|195976775 dysferlin isoform 4 [Homo sapiens]
          Length = 2098

 Score = 2372 bits (6147), Expect = 0.0
 Identities = 1179/2140 (55%), Positives = 1518/2140 (70%), Gaps = 125/2140 (5%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE----------------- 151
            L + Y P     P  P P  L   P++P +     GG    +                  
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKK 179

Query: 152  --------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVK 186
                    G+ED  D  + G   +       GP    +  +L           +R     
Sbjct: 180  WPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAP 239

Query: 187  NSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFF 246
             SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F
Sbjct: 240  TSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLF 299

Query: 247  YNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPE 306
            +N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+
Sbjct: 300  FNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPD 359

Query: 307  DTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYR 366
            D S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++R
Sbjct: 360  DFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFR 419

Query: 367  AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
            AED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + 
Sbjct: 420  AEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNIT 479

Query: 427  LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTV 486
            L   FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E              
Sbjct: 480  LPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE-------------- 525

Query: 487  NTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLE 546
               +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L 
Sbjct: 526  --VDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLV 583

Query: 547  KTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKF 606
            +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKF
Sbjct: 584  E-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKF 642

Query: 607  DTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAER 666
            D TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+R
Sbjct: 643  DMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 702

Query: 667  LQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLR 726
            L+  +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR
Sbjct: 703  LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLR 762

Query: 727  SRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRL 786
            +  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+
Sbjct: 763  THHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRV 822

Query: 787  AYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVE 846
            AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  E
Sbjct: 823  AYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDE 882

Query: 847  KKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKG 904
            K+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  G
Sbjct: 883  KEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAG 941

Query: 905  WEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASP 964
            W W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K    
Sbjct: 942  WTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPK 1001

Query: 965  SELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLV 1024
             ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR V
Sbjct: 1002 DDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWV 1061

Query: 1025 RKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSE 1084
            R R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E
Sbjct: 1062 RLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLE 1120

Query: 1085 THGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCY 1144
              G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY
Sbjct: 1121 KTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCY 1175

Query: 1145 VYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTV 1204
            +YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV
Sbjct: 1176 MYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATV 1235

Query: 1205 LQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVL 1264
             + PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L
Sbjct: 1236 AEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELL 1289

Query: 1265 VTAELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQL 1303
             + ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q 
Sbjct: 1290 ASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQR 1349

Query: 1304 TAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFL 1363
            TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V L
Sbjct: 1350 TAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVML 1409

Query: 1364 PKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLL 1420
            P+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLL
Sbjct: 1410 PREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLL 1468

Query: 1421 SAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKI 1480
            S  P  D++I+++D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+
Sbjct: 1469 S--PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKV 1522

Query: 1481 YNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPP 1539
            Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PP
Sbjct: 1523 YDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPP 1582

Query: 1540 RQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLN 1599
            RQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL 
Sbjct: 1583 RQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLE 1642

Query: 1600 PVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEY 1659
            PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ Y
Sbjct: 1643 PVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTY 1702

Query: 1660 CVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQH 1719
            CVSG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I + H
Sbjct: 1703 CVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPH 1760

Query: 1720 LGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFN 1779
            LG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFN
Sbjct: 1761 LGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFN 1820

Query: 1780 ITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLD 1839
            ITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL 
Sbjct: 1821 ITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLG 1880

Query: 1840 GEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYL 1899
            GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+L
Sbjct: 1881 GEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFL 1940

Query: 1900 GFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGA 1959
            G L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   
Sbjct: 1941 GSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEK 1996

Query: 1960 RVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFI 2019
            +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI
Sbjct: 1997 KILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFI 2056

Query: 2020 VWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2059
            +WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2057 LWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2096


>gi|195976756 dysferlin isoform 10 [Homo sapiens]
          Length = 2087

 Score = 2372 bits (6147), Expect = 0.0
 Identities = 1178/2125 (55%), Positives = 1510/2125 (71%), Gaps = 106/2125 (4%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPD 518
            L +SKI+A GGE+E                 +  +GF+PTFGPCY+NLYGSPRE+TGFPD
Sbjct: 480  LSMSKISAPGGEIE----------------VDDYLGFLPTFGPCYINLYGSPREFTGFPD 523

Query: 519  PYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSA 578
            PY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A
Sbjct: 524  PYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFA 582

Query: 579  VFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTK 638
             F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + K
Sbjct: 583  AFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVK 642

Query: 639  PVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEV 698
            PVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+
Sbjct: 643  PVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDEL 702

Query: 699  IEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWL 758
            I      L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL
Sbjct: 703  IAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWL 762

Query: 759  DKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFL 818
             +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFL
Sbjct: 763  LRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFL 822

Query: 819  KYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGT 876
            KYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT
Sbjct: 823  KYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGT 882

Query: 877  SGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQ 936
            +GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++
Sbjct: 883  TGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFE 941

Query: 937  NESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYG 996
            N++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY 
Sbjct: 942  NQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYS 1001

Query: 997  ITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASL 1056
            ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL
Sbjct: 1002 ITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASL 1060

Query: 1057 IGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKH 1116
             GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E    
Sbjct: 1061 FGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMS 1115

Query: 1117 SATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTE 1176
             +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T 
Sbjct: 1116 VSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTV 1175

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P  
Sbjct: 1176 VVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP-- 1233

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------D 1275
                 ++  P+L W P+  G +  G++L + ELI R K                     +
Sbjct: 1234 ----SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESE 1289

Query: 1276 GSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGG 1335
             ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG
Sbjct: 1290 DTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGG 1349

Query: 1336 ERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIE 1395
            + V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI 
Sbjct: 1350 QTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIR 1409

Query: 1396 RLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE------- 1445
             L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+  +L +       
Sbjct: 1410 SLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLAP 1466

Query: 1446 ----------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLT 1495
                       EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+
Sbjct: 1467 TNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLS 1526

Query: 1496 DFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECT 1554
            DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC 
Sbjct: 1527 DFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECL 1586

Query: 1555 VRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQ 1614
            VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP 
Sbjct: 1587 VRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPL 1646

Query: 1615 EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPT 1674
            EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+
Sbjct: 1647 EKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPS 1706

Query: 1675 QLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRT 1734
            QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ 
Sbjct: 1707 QLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQ 1764

Query: 1735 QGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVII 1794
            QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR II
Sbjct: 1765 QGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCII 1824

Query: 1795 WNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDY 1854
            WNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDY
Sbjct: 1825 WNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDY 1884

Query: 1855 LPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAK 1914
            LPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK
Sbjct: 1885 LPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAK 1944

Query: 1915 SPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILN 1974
            + +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ 
Sbjct: 1945 TAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVA 2000

Query: 1975 EKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFL 2034
            E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L
Sbjct: 2001 ESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIIL 2060

Query: 2035 LILLLFVAVLLYSLPNYLSMKIVKP 2059
             ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2061 FILLLFLAIFIYAFPNYAAMKLVKP 2085


>gi|195976760 dysferlin isoform 12 [Homo sapiens]
          Length = 2111

 Score = 2370 bits (6143), Expect = 0.0
 Identities = 1177/2139 (55%), Positives = 1516/2139 (70%), Gaps = 110/2139 (5%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE------------------ 151
             + Y P     P  P P  L   P++P +     GG    +                   
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW 179

Query: 152  -------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVKN 187
                   G+ED  D  + G   +       GP    +  +L           +R      
Sbjct: 180  PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 188  SRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFY 247
            SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F+
Sbjct: 240  SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF 299

Query: 248  NVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED 307
            N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+D
Sbjct: 300  NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD 359

Query: 308  TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRA 367
             S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++RA
Sbjct: 360  FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA 419

Query: 368  EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNL 427
            ED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + L
Sbjct: 420  EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL 479

Query: 428  QIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVN 487
               FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E+  +     +    +
Sbjct: 480  PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSK--AS 537

Query: 488  TGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEK 547
              +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +
Sbjct: 538  DLDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE 597

Query: 548  TPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFD 607
               ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD
Sbjct: 598  -HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFD 656

Query: 608  TTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERL 667
             TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL
Sbjct: 657  MTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRL 716

Query: 668  QTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRS 727
            +  +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR+
Sbjct: 717  EAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRT 776

Query: 728  RSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLA 787
              LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+A
Sbjct: 777  HHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVA 836

Query: 788  YARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEK 847
            Y R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK
Sbjct: 837  YQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEK 896

Query: 848  KFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGW 905
            +FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW
Sbjct: 897  EFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGW 955

Query: 906  EWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPS 965
             W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     
Sbjct: 956  TWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKD 1015

Query: 966  ELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVR 1025
            ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR
Sbjct: 1016 DIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVR 1075

Query: 1026 KRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSET 1085
             R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E 
Sbjct: 1076 LRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEK 1134

Query: 1086 HGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYV 1145
             G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY+
Sbjct: 1135 TGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYM 1189

Query: 1146 YQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVL 1205
            YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV 
Sbjct: 1190 YQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVA 1249

Query: 1206 QNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLV 1265
            + PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L 
Sbjct: 1250 EQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLA 1303

Query: 1266 TAELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLT 1304
            + ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q T
Sbjct: 1304 SFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRT 1363

Query: 1305 AIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLP 1364
            AIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP
Sbjct: 1364 AIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLP 1423

Query: 1365 KEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLS 1421
            +EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS
Sbjct: 1424 REELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS 1482

Query: 1422 APPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIY 1481
              P  D++I+++D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y
Sbjct: 1483 --PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVY 1536

Query: 1482 NCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPR 1540
            + +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPR
Sbjct: 1537 DTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPR 1596

Query: 1541 QFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNP 1600
            QF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL P
Sbjct: 1597 QFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEP 1656

Query: 1601 VFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYC 1660
            VFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YC
Sbjct: 1657 VFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYC 1716

Query: 1661 VSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHL 1720
            VSG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I + HL
Sbjct: 1717 VSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHL 1774

Query: 1721 GAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNI 1780
            G  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNI
Sbjct: 1775 GPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNI 1834

Query: 1781 TPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDG 1840
            TPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL G
Sbjct: 1835 TPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGG 1894

Query: 1841 EGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLG 1900
            EGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG
Sbjct: 1895 EGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLG 1954

Query: 1901 FLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGAR 1960
             L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +
Sbjct: 1955 SLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKK 2010

Query: 1961 VMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIV 2020
            ++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+
Sbjct: 2011 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2070

Query: 2021 WRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2059
            WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2071 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2109


>gi|195976779 dysferlin isoform 1 [Homo sapiens]
          Length = 2119

 Score = 2369 bits (6139), Expect = 0.0
 Identities = 1180/2157 (54%), Positives = 1520/2157 (70%), Gaps = 138/2157 (6%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE----------------- 151
            L + Y P     P  P P  L   P++P +     GG    +                  
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKK 179

Query: 152  --------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVK 186
                    G+ED  D  + G   +       GP    +  +L           +R     
Sbjct: 180  WPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAP 239

Query: 187  NSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFF 246
             SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F
Sbjct: 240  TSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLF 299

Query: 247  YNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPE 306
            +N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+
Sbjct: 300  FNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPD 359

Query: 307  DTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYR 366
            D S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++R
Sbjct: 360  DFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFR 419

Query: 367  AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
            AED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + 
Sbjct: 420  AEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNIT 479

Query: 427  LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTV 486
            L   FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E              
Sbjct: 480  LPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE-------------- 525

Query: 487  NTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLE 546
               +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L 
Sbjct: 526  --VDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLV 583

Query: 547  KTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKF 606
            +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKF
Sbjct: 584  E-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKF 642

Query: 607  DTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAER 666
            D TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+R
Sbjct: 643  DMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADR 702

Query: 667  LQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLR 726
            L+  +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR
Sbjct: 703  LEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLR 762

Query: 727  SRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRL 786
            +  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+
Sbjct: 763  THHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRV 822

Query: 787  AYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVE 846
            AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  E
Sbjct: 823  AYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDE 882

Query: 847  KKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKG 904
            K+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  G
Sbjct: 883  KEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAG 941

Query: 905  WEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASP 964
            W W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K    
Sbjct: 942  WTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPK 1001

Query: 965  SELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLV 1024
             ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR V
Sbjct: 1002 DDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWV 1061

Query: 1025 RKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSE 1084
            R R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E
Sbjct: 1062 RLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLE 1120

Query: 1085 THGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCY 1144
              G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY
Sbjct: 1121 KTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCY 1175

Query: 1145 VYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTV 1204
            +YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV
Sbjct: 1176 MYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATV 1235

Query: 1205 LQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVL 1264
             + PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L
Sbjct: 1236 AEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELL 1289

Query: 1265 VTAELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQL 1303
             + ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q 
Sbjct: 1290 ASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQR 1349

Query: 1304 TAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFL 1363
            TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V L
Sbjct: 1350 TAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVML 1409

Query: 1364 PKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLL 1420
            P+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLL
Sbjct: 1410 PREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLL 1468

Query: 1421 SAPPCRDIVIEMEDTKPLLASKLTE-----------------KEEEIVDWWSKFYASSGE 1463
            S  P  D++I+++D +PL+  +L +                  EEE +DWWSKF+AS GE
Sbjct: 1469 S--PGEDVLIDIDDKEPLIPIQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGE 1526

Query: 1464 HEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKG 1522
             EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG
Sbjct: 1527 REKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKG 1586

Query: 1523 SFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL 1582
             F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++
Sbjct: 1587 LFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISI 1646

Query: 1583 GKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLE 1642
            GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLE
Sbjct: 1647 GKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLE 1706

Query: 1643 NRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGG 1702
            NR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+   D  R+ +  
Sbjct: 1707 NRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQD 1764

Query: 1703 RDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQM 1762
            ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQM
Sbjct: 1765 KEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQM 1824

Query: 1763 WVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIP 1822
            WVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ 
Sbjct: 1825 WVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMI 1884

Query: 1823 GNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPR 1882
            G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R
Sbjct: 1885 GFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPAR 1944

Query: 1883 LIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFE 1942
            ++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +P      SLFE
Sbjct: 1945 VVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFE 2000

Query: 1943 QKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRP 2002
            QK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP
Sbjct: 2001 QKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRP 2060

Query: 2003 ETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2059
            +TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2061 DTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2117


>gi|195976762 dysferlin isoform 13 [Homo sapiens]
          Length = 2097

 Score = 2367 bits (6133), Expect = 0.0
 Identities = 1177/2139 (55%), Positives = 1512/2139 (70%), Gaps = 124/2139 (5%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE------------------ 151
             + Y P     P  P P  L   P++P +     GG    +                   
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW 179

Query: 152  -------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVKN 187
                   G+ED  D  + G   +       GP    +  +L           +R      
Sbjct: 180  PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 188  SRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFY 247
            SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F+
Sbjct: 240  SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF 299

Query: 248  NVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED 307
            N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+D
Sbjct: 300  NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD 359

Query: 308  TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRA 367
             S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++RA
Sbjct: 360  FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA 419

Query: 368  EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNL 427
            ED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + L
Sbjct: 420  EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL 479

Query: 428  QIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVN 487
               FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E               
Sbjct: 480  PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE--------------- 524

Query: 488  TGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEK 547
              +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +
Sbjct: 525  -VDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE 583

Query: 548  TPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFD 607
               ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD
Sbjct: 584  -HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFD 642

Query: 608  TTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERL 667
             TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL
Sbjct: 643  MTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRL 702

Query: 668  QTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRS 727
            +  +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR+
Sbjct: 703  EAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRT 762

Query: 728  RSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLA 787
              LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+A
Sbjct: 763  HHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVA 822

Query: 788  YARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEK 847
            Y R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK
Sbjct: 823  YQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEK 882

Query: 848  KFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGW 905
            +FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW
Sbjct: 883  EFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGW 941

Query: 906  EWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPS 965
             W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     
Sbjct: 942  TWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKD 1001

Query: 966  ELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVR 1025
            ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR
Sbjct: 1002 DIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVR 1061

Query: 1026 KRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSET 1085
             R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E 
Sbjct: 1062 LRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEK 1120

Query: 1086 HGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYV 1145
             G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY+
Sbjct: 1121 TGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYM 1175

Query: 1146 YQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVL 1205
            YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV 
Sbjct: 1176 YQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVA 1235

Query: 1206 QNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLV 1265
            + PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L 
Sbjct: 1236 EQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLA 1289

Query: 1266 TAELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLT 1304
            + ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q T
Sbjct: 1290 SFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRT 1349

Query: 1305 AIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLP 1364
            AIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP
Sbjct: 1350 AIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLP 1409

Query: 1365 KEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLS 1421
            +EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS
Sbjct: 1410 REELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS 1468

Query: 1422 APPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIY 1481
              P  D++I+++D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y
Sbjct: 1469 --PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVY 1522

Query: 1482 NCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPR 1540
            + +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPR
Sbjct: 1523 DTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPR 1582

Query: 1541 QFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNP 1600
            QF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL P
Sbjct: 1583 QFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEP 1642

Query: 1601 VFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYC 1660
            VFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YC
Sbjct: 1643 VFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYC 1702

Query: 1661 VSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHL 1720
            VSG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I + HL
Sbjct: 1703 VSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHL 1760

Query: 1721 GAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNI 1780
            G  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNI
Sbjct: 1761 GPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNI 1820

Query: 1781 TPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDG 1840
            TPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL G
Sbjct: 1821 TPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGG 1880

Query: 1841 EGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLG 1900
            EGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG
Sbjct: 1881 EGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLG 1940

Query: 1901 FLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGAR 1960
             L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +
Sbjct: 1941 SLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKK 1996

Query: 1961 VMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIV 2020
            ++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+
Sbjct: 1997 ILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFIL 2056

Query: 2021 WRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2059
            WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2057 WRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2095


>gi|195976764 dysferlin isoform 14 [Homo sapiens]
          Length = 2118

 Score = 2363 bits (6125), Expect = 0.0
 Identities = 1178/2156 (54%), Positives = 1514/2156 (70%), Gaps = 137/2156 (6%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE------------------ 151
             + Y P     P  P P  L   P++P +     GG    +                   
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW 179

Query: 152  -------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVKN 187
                   G+ED  D  + G   +       GP    +  +L           +R      
Sbjct: 180  PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 188  SRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFY 247
            SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F+
Sbjct: 240  SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF 299

Query: 248  NVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED 307
            N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+D
Sbjct: 300  NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD 359

Query: 308  TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRA 367
             S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++RA
Sbjct: 360  FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA 419

Query: 368  EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNL 427
            ED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + L
Sbjct: 420  EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL 479

Query: 428  QIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVN 487
               FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E               
Sbjct: 480  PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIE--------------- 524

Query: 488  TGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEK 547
              +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +
Sbjct: 525  -VDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE 583

Query: 548  TPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFD 607
               ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD
Sbjct: 584  -HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFD 642

Query: 608  TTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERL 667
             TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL
Sbjct: 643  MTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRL 702

Query: 668  QTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRS 727
            +  +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR+
Sbjct: 703  EAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRT 762

Query: 728  RSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLA 787
              LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+A
Sbjct: 763  HHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVA 822

Query: 788  YARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEK 847
            Y R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK
Sbjct: 823  YQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEK 882

Query: 848  KFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGW 905
            +FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW
Sbjct: 883  EFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGW 941

Query: 906  EWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPS 965
             W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     
Sbjct: 942  TWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKD 1001

Query: 966  ELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVR 1025
            ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR
Sbjct: 1002 DIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVR 1061

Query: 1026 KRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSET 1085
             R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E 
Sbjct: 1062 LRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEK 1120

Query: 1086 HGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYV 1145
             G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY+
Sbjct: 1121 TGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYM 1175

Query: 1146 YQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVL 1205
            YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV 
Sbjct: 1176 YQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVA 1235

Query: 1206 QNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLV 1265
            + PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L 
Sbjct: 1236 EQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLA 1289

Query: 1266 TAELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLT 1304
            + ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q T
Sbjct: 1290 SFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRT 1349

Query: 1305 AIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLP 1364
            AIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP
Sbjct: 1350 AIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLP 1409

Query: 1365 KEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLS 1421
            +EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS
Sbjct: 1410 REELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS 1468

Query: 1422 APPCRDIVIEMEDTKPLLASKLTE-----------------KEEEIVDWWSKFYASSGEH 1464
              P  D++I+++D +PL+  +L +                  EEE +DWWSKF+AS GE 
Sbjct: 1469 --PGEDVLIDIDDKEPLIPIQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGER 1526

Query: 1465 EKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGS 1523
            EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG 
Sbjct: 1527 EKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGL 1586

Query: 1524 FRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLG 1583
            F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++G
Sbjct: 1587 FKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIG 1646

Query: 1584 KKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLEN 1643
            KK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLEN
Sbjct: 1647 KKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLEN 1706

Query: 1644 RFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGR 1703
            R LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+   D  R+ +  +
Sbjct: 1707 RLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDK 1764

Query: 1704 DYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMW 1763
            +YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMW
Sbjct: 1765 EYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMW 1824

Query: 1764 VDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPG 1823
            VD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G
Sbjct: 1825 VDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIG 1884

Query: 1824 NEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRL 1883
             EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R+
Sbjct: 1885 FEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARV 1944

Query: 1884 IIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQ 1943
            + QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +P      SLFEQ
Sbjct: 1945 VFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQ 2000

Query: 1944 KSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPE 2003
            K++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+
Sbjct: 2001 KTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPD 2060

Query: 2004 TSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2059
            TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2061 TSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2116


>gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]
          Length = 2093

 Score = 1528 bits (3957), Expect = 0.0
 Identities = 852/2128 (40%), Positives = 1222/2128 (57%), Gaps = 164/2128 (7%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLR++V+SA   P      P P +S+ F+D KK+T+ V+   +PVWNE L + L   PL+
Sbjct: 1    MLRLVVQSAKIDPPLA-PLPRPCMSIDFRDIKKRTRVVEGN-DPVWNETLIWHLWNRPLE 58

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L + ++D  +  + + IG ATV LK L    S  L  K ++LLN   + T  T+ L
Sbjct: 59   NDSFLQVTLQDMGSQKKERFIGLATVLLKPLLKQPSEVLFVKDLTLLNHSMKPTDCTVTL 118

Query: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180
             + +                  M     E  G ED L    R            EA   +
Sbjct: 119  QVAH------------------MSNQDIEKTGAEDHLGITAR------------EAASQK 148

Query: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240
             +     + R LS+KPQ FQ+RV+V E RQL GNNI+PVVKV + GQ H+TRIK GNNPF
Sbjct: 149  LMVPGSTAHRALSSKPQHFQVRVKVFEARQLMGNNIKPVVKVSIAGQQHQTRIKMGNNPF 208

Query: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300
            F+E+FF N +  P++  DE I I+                  D+GF+Y  PGH ++RKWL
Sbjct: 209  FNEIFFQNFHEVPAKFFDETILIQT-----------------DIGFIYHSPGHTLLRKWL 251

Query: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360
             L  P +  SG  GY+KV+++ LG GD+   +++     +DD +  +   A + +     
Sbjct: 252  GLCQPNNPGSGVTGYLKVTIYALGVGDQALIDQKLLYG-TDDTDIQIFKSAVVPINMAYL 310

Query: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420
             L IY AED+                 +  K   V+P +EV   G+K+ T++  +  NP 
Sbjct: 311  QLFIYCAEDL-----------------HLKKHQSVNPQLEVELIGEKLRTHMQTQTDNPI 353

Query: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTG 480
            WNQ++  +I+ P +   IK  + D  +    D +GT  L L++I+++G E+E     G  
Sbjct: 354  WNQILTFRIQLPCLSSYIKFRVLDCRKKDCPDEIGTASLSLNQISSTGEEIE-----GKQ 408

Query: 481  AASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 540
            +   T  T     GF+P FGP +L L+G  +      +    +     +G+AYRGR+ +E
Sbjct: 409  SLEPTSYTPRVYSGFLPCFGPSFLTLHGGKKAPFRIQEEGACIPDSVRDGLAYRGRVFLE 468

Query: 541  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 600
            L T + K+  D  ++ +S++ +  +EK+Q R+KY L  +F S TM+ +  E I FEVSIG
Sbjct: 469  LITQI-KSYQDSTIKDLSHE-VTRIEKHQNRQKYGLCVIFLSCTMMPNFKELIHFEVSIG 526

Query: 601  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 660
            +YGNK D   KPL S+T YS  ++DGN Y+Y+PW +TKPVV +TS WED+S R++ +N L
Sbjct: 527  HYGNKMDLNYKPLVSSTPYSPVIYDGNIYHYVPWYNTKPVVAVTSNWEDVSFRMNCLNLL 586

Query: 661  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 720
                +RL+ N++ LKS    K PA  L   W KL+ E+ ED +  LP    +   T LD 
Sbjct: 587  HFTRDRLKANLDTLKSTRNPKDPA--LLYQWEKLLRELAEDCKRPLPCMTYQPKATSLDR 644

Query: 721  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 780
            +  +LRS  L ++ + A + +      K  +A  EDWL +L  +  EPQ  +PD++IW++
Sbjct: 645  KRWQLRSLLLQELAQKAKQAKP-----KDMVATAEDWLYRLNTVLPEPQMGLPDVMIWLV 699

Query: 781  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 840
              E+R+AYA++PAH VL+S +G   SG+ CGK QT+FL+YP+ +     +P  LRV +WL
Sbjct: 700  AKEQRVAYAQVPAHSVLFSPAGALHSGRLCGKIQTLFLQYPEGEGQKDVLPAHLRVCMWL 759

Query: 841  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 900
            G     K      +G   V+AEMYENQA    +WG  GL     FSDV G   L    F 
Sbjct: 760  GNVTDSKDLQLLRQGDTAVYAEMYENQAKYKDQWGQQGLYHCPNFSDVMGNKTLPMTDFQ 819

Query: 901  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 960
            PP GW W+  W V+P+R LL + D   ++  +EVY+N+ R   G W PA    TD NG  
Sbjct: 820  PPLGWHWQDSWTVEPQRRLLLDIDINKSQVLEEVYENQGRDTRGAWGPAAIPNTDVNGQP 879

Query: 961  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1020
              +   + CP GW ++ D W  ++N AVD   WEYG+ IPP   P+ W   EK YH+ RR
Sbjct: 880  MEARENVKCPQGWHFKKD-WVVELNHAVDS--WEYGVGIPPSGLPQVWSPVEKTYHSCRR 936

Query: 1021 RRLVRKRKKDLTQTASSTARAMEELQ------DQEGWEYASLIGWKFHWKQRSSDTFRRR 1074
            RR  R R ++  +  S     +  LQ      ++EGWEY +  G KFH   +    FRRR
Sbjct: 937  RRWARVRFRNHGEL-SHEQETLSFLQLGLAKGEEEGWEYDTF-GSKFHLNPQPQSRFRRR 994

Query: 1075 RWRRKMAPSETHGAAAIFKLEGAL---GADTTEDGD------------------------ 1107
             WRR++AP++  G A IF LEG+L   G    E+GD                        
Sbjct: 995  CWRRRLAPNKDKGIAPIFLLEGSLACEGGSVREEGDWAWARGNRSSTQEPQGRLSWVQAM 1054

Query: 1108 --EKSLEKQKHSATTVFGA---------------NTPIVSCNFDRVYIYHLRCYVYQARN 1150
              +    K++ S T  +G                N P + C F++ + Y L CY+YQARN
Sbjct: 1055 DLKYHAGKEEDSKTWPWGLDRQFRDPQRQDTRPPNLPFIYCTFNKPHYYQLFCYIYQARN 1114

Query: 1151 LLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPK 1210
            L++    +F  P+  + FL+ S+ T+ + S+  PTW QT+IF  + +Y  PQ   ++PP 
Sbjct: 1115 LVSNQILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIFQHLLLYENPQDTKESPPL 1174

Query: 1211 VIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNG-DKACGDVLVTAEL 1269
            V++EL+  D  GK+   GRS++ P+V L+ +  I P + WHP++    K  G++L + EL
Sbjct: 1175 VVLELWQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHPLVKELGKEEGEILASCEL 1234

Query: 1270 ILRGKD--GSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSP 1327
            IL+ +      LPIL        Y +P+ I+P ++  AIEILAWGLRNMK       +SP
Sbjct: 1235 ILQTEKLGEKQLPILSVPWKNGAYTLPKSIQPTIKRMAIEILAWGLRNMKK-----ASSP 1289

Query: 1328 SLVVECGGERVESVVIKNLKKTPNFPSS--VLFMKVFLPKEELYMPPLVIKVIDHRQFGR 1385
             L+VE G E + +  I++ +  PNFP S  VL + V +P EE Y  PLV+KV+D+  FG+
Sbjct: 1290 QLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVVDNWAFGQ 1349

Query: 1386 KPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTE 1445
            + V GQ  I+ L  + CDP+A ++ + P+L    LS    +D +  +       +SK  +
Sbjct: 1350 QTVTGQANIDFLQPYFCDPWA-QDYMHPKLPT--LSEKKHQDFLGYLYRKFWFKSSKAED 1406

Query: 1446 KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYR 1505
            + E  VDWWSK + ++ EH+   +Y  K Y  LK+Y CELE V  F+GL DF  TFKLY+
Sbjct: 1407 EYEHEVDWWSKLFWATDEHKSL-KYKYKDYHTLKVYECELEAVPAFQGLQDFCQTFKLYQ 1465

Query: 1506 GKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPD--SVPQECTVRIYIVRGL 1563
                   D  VVGEFKG FRIYP P++P  P PP QF   P+    PQ C VR+Y+VR +
Sbjct: 1466 --EQPKLDSPVVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVRVYMVRAI 1523

Query: 1564 ELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVY 1623
             LQPQD NGLCDPY+ + LGK  + +RD Y PNTL+P+FG M+EL+C +P EKDL+I +Y
Sbjct: 1524 NLQPQDYNGLCDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLY 1583

Query: 1624 DYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARF 1683
            D+D F+ D+K+G T+IDLENR LS FG+HCG+ + YC SG   WRDQ+ P+ LL+  A+ 
Sbjct: 1584 DFDLFSPDDKIGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKR 1643

Query: 1684 KGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVE 1743
            KG P P+ S +   + Y G+ + L  FE        LG  +ERLAL++L TQGLVPEHVE
Sbjct: 1644 KGLPPPLFSPEEDAVFYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQGLVPEHVE 1703

Query: 1744 TRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAK---------KYYLRVII 1794
            TRTL+S  QP I QGK+QMWVD+FPK LGPPGP  NI PRK K         +Y LR II
Sbjct: 1704 TRTLYSHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRKASEHSGHRYELRCII 1763

Query: 1795 WNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDY 1854
            W T +V L + +++ E+ SDIY+KGW+ G E++ QKTD+HY SL GE +FNWRF+F  DY
Sbjct: 1764 WKTANVDLVDDNLSREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDY 1823

Query: 1855 LPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAK 1914
            L AE+ C+ ++K++ WS+D T  + P RLIIQ+WDND FS DD+LG LELDL    +PA+
Sbjct: 1824 LAAERTCVQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPAR 1883

Query: 1915 SPEKCRLDMI-PDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEIL 1973
              ++C + M+  D K    ++ K  SLF++K++ GWWPC     G   ++GKV+M+LEIL
Sbjct: 1884 HAKQCSIRMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLEIL 1943

Query: 1974 NEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLF 2033
            +EKEA  +PAG+G+ EPN  P L  P R  TSF W  +P +   +I W+R+++ +I  + 
Sbjct: 1944 SEKEALIKPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMV 2003

Query: 2034 LLILLLFVAVLLYSLPNYLSMKIVKPNV 2061
            + I+ L +   +YS P+YL+M  +KP +
Sbjct: 2004 ISIIALMLFNFIYSAPHYLAMSWIKPQL 2031


>gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]
          Length = 802

 Score =  718 bits (1853), Expect = 0.0
 Identities = 357/746 (47%), Positives = 493/746 (66%), Gaps = 11/746 (1%)

Query: 1321 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSS--VLFMKVFLPKEELYMPPLVIKVI 1378
            M   +SP L+VE G E + +  I++ +  PNFP S  VL + V +P EE Y  PLV+KV+
Sbjct: 1    MKKASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVV 60

Query: 1379 DHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPL 1438
            D+  FG++ V GQ  I+ L  + CDP+A ++ + P+L    LS    +D +  +      
Sbjct: 61   DNWAFGQQTVTGQANIDFLQPYFCDPWA-QDYMHPKLPT--LSEKKHQDFLGYLYRKFWF 117

Query: 1439 LASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFS 1498
             +SK  ++ E  VDWWSK + ++ EH+   +Y  K Y  LK+Y CELE V  F+GL DF 
Sbjct: 118  KSSKAEDEYEHEVDWWSKLFWATDEHKSL-KYKYKDYHTLKVYECELEAVPAFQGLQDFC 176

Query: 1499 DTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPD--SVPQECTVR 1556
             TFKLY+       D  VVGEFKG FRIYP P++P  P PP QF   P+    PQ C VR
Sbjct: 177  QTFKLYQ--EQPKLDSPVVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVR 234

Query: 1557 IYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEK 1616
            +Y+VR + LQPQD NGLCDPY+ + LGK  + +RD Y PNTL+P+FG M+EL+C +P EK
Sbjct: 235  VYMVRAINLQPQDYNGLCDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEK 294

Query: 1617 DLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQL 1676
            DL+I +YD+D F+ D+K+G T+IDLENR LS FG+HCG+ + YC SG   WRDQ+ P+ L
Sbjct: 295  DLEIQLYDFDLFSPDDKIGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYL 354

Query: 1677 LQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQG 1736
            L+  A+ KG P P+ S +   + Y G+ + L  FE        LG  +ERLAL++L TQG
Sbjct: 355  LERYAKRKGLPPPLFSPEEDAVFYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQG 414

Query: 1737 LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWN 1796
            LVPEHVETRTL+S  QP I QGK+QMWVD+FPK LGPPGP  NI PRK K+Y LR IIW 
Sbjct: 415  LVPEHVETRTLYSHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWK 474

Query: 1797 TKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLP 1856
            T +V L + +++ E+ SDIY+KGW+ G E++ QKTD+HY SL GE +FNWRF+F  DYL 
Sbjct: 475  TANVDLVDDNLSREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLA 534

Query: 1857 AEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSP 1916
            AE+ C+ ++K++ WS+D T  + P RLIIQ+WDND FS DD+LG LELDL    +PA+  
Sbjct: 535  AERTCVQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHA 594

Query: 1917 EKCRLDMI-PDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNE 1975
            ++C + M+  D K    ++ K  SLF++K++ GWWPC     G   ++GKV+M+LEIL+E
Sbjct: 595  KQCSIRMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLEILSE 654

Query: 1976 KEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLL 2035
            KEA  +PAG+G+ EPN  P L  P R  TSF W  +P +   +I W+R+++ +I  + + 
Sbjct: 655  KEALIKPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVIS 714

Query: 2036 ILLLFVAVLLYSLPNYLSMKIVKPNV 2061
            I+ L +   +YS P+YL+M  +KP +
Sbjct: 715  IIALMLFNFIYSAPHYLAMSWIKPQL 740


>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score =  689 bits (1779), Expect = 0.0
 Identities = 393/1066 (36%), Positives = 585/1066 (54%), Gaps = 152/1066 (14%)

Query: 1123 GANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTL 1182
            G N P  +  +   +++ LR ++YQAR L+A D +  SDP+A + FL   +TT+II  TL
Sbjct: 810  GTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTL 869

Query: 1183 NPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM 1242
            +PTW+Q ++F+++ ++G+ + + ++PP V++EL+D+D VGK E+LG ++ +PVVKL  + 
Sbjct: 870  SPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQD 929

Query: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDG-SNLPILPPQRAPNLYMVPQGIRPVV 1301
               P+L +HP+  G+ + GD+L   EL+     G   LP + P     +Y VP  IRPV+
Sbjct: 930  YEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVL 989

Query: 1302 QLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKV 1361
                +E+L WG+R MK  Q+ S+  P  ++ECGG+ V+S VI++ K  PNF       +V
Sbjct: 990  SKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEV 1049

Query: 1362 FLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRC------------DPYAGKE 1409
             LP+ EL  PPL I V+D R FGR  +VG  TI  L +F C            D      
Sbjct: 1050 ELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGH 1109

Query: 1410 DIVPQLKASLLSA-------PPCRDIVIEME---------------------DTKPLLAS 1441
            DI   L A+  S        PP   I +++E                     D+ P+L  
Sbjct: 1110 DISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEP 1169

Query: 1442 KLT--------------------------------EKEEEIVDWWSKFYASSGEHEKCGQ 1469
            + T                                E  E ++DWWSK+YAS  + +K  +
Sbjct: 1170 EHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKE 1229

Query: 1470 YIQKG---------------------------------------YSKLKIYNCELENVAE 1490
               KG                                        + L+IY+ +LE+  E
Sbjct: 1230 RNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLKKKPKDDGIPNLAILQIYDGDLES--E 1287

Query: 1491 FEGLTDFSDTFKLYRGKSDENED----PSVVGEFKGSFRIYPLPDDPSVP--APPRQFRE 1544
            F    D+  TF+L+RGKS E++       V+G+FKGSF IY  P D S       R  + 
Sbjct: 1288 FNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSGQLRIQQG 1347

Query: 1545 LPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGR 1604
            +P + P    +R+YIV    L P D +G  DPYI I LGK  I+DRD YIP  LNPVFGR
Sbjct: 1348 IPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGR 1407

Query: 1605 MYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGV 1664
             +E+    P+E  L I +YD+D    D+ +GET IDLENRF S+  + CG+  +Y + G 
Sbjct: 1408 SFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGY 1467

Query: 1665 NTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS----LDEFEANKILHQHL 1720
            N WRD  +PT++L  + +      P       +I+ G + +S      E + ++ +  + 
Sbjct: 1468 NAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESY- 1524

Query: 1721 GAPEERLALHILRTQG--------LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLG 1772
                E LAL +L +          LVPEH+ETR L+   +P + QG+LQMWVD+FPK + 
Sbjct: 1525 ----EHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMP 1580

Query: 1773 PPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSI-TGEEMSDIYVKGWIPGNEENKQKT 1831
             PGPP +I+PR+ K Y LRV IWNT+DVIL++++I TG++ SDIYVKGW+ G E++KQ+T
Sbjct: 1581 QPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQET 1640

Query: 1832 DVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDND 1891
            DVHY SL GEGNFNWRF+FPF YLPAE+  ++ K+E+ +S+++ E + P  L++Q+WD +
Sbjct: 1641 DVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFE 1700

Query: 1892 KFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWP 1951
            + S DD+LG LE++L      AKS + C L      K  N  +    S+F+QK ++GWWP
Sbjct: 1701 RLSSDDFLGTLEMNLNSFPRAAKSAKACDL-----AKFENASEETKISIFQQKRVRGWWP 1755

Query: 1952 CYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTN 2011
                K+    + GKVE    ++  +EA++ P GK R EP     L  PNRP+TSF WF +
Sbjct: 1756 FSKSKE----LTGKVEAEFHLVTAEEAEKNPVGKARKEPE---PLAKPNRPDTSFSWFMS 1808

Query: 2012 PCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2057
            P K + +++W+ +K  II    L+IL++F+ + +Y+LP  +S +IV
Sbjct: 1809 PFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854



 Score =  349 bits (896), Expect = 1e-95
 Identities = 250/795 (31%), Positives = 396/795 (49%), Gaps = 136/795 (17%)

Query: 148 EEDEGDEDRL-DNAVRGPGPKG----------PVGTVSEAQLARRLTKVKNSRRMLSNKP 196
           ++ +GD + L +      GP+G          PV + S  + ++ LTK+ +       + 
Sbjct: 25  KDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEV----RS 80

Query: 197 QDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRG-NNPFFDELFFYNVNMTPSE 255
           Q++QI + + E RQL G NI PVV + +  +  ++ +K G N+PF++E F ++       
Sbjct: 81  QNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVH 140

Query: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGY 315
           L D+II I V++ H L    L+G FK+D+G VY++PGH    KW LL DP D  +G+KGY
Sbjct: 141 LFDKIIKISVFH-HKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGY 199

Query: 316 MKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALR--WVTFLLKIYRAEDIPQM 373
           +K  + V+G GD      +  D + + +E NLL+P G  L   W  F +++Y+AE +P+M
Sbjct: 200 LKCDISVMGKGDVLKTSPKTSDTE-EPIEKNLLIPNGFPLERPWARFYVRLYKAEGLPKM 258

Query: 374 DDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPS 433
           + +    V + F G  D K+LVDPFVEVSFAG+   T + +  A+P W++ V  +  FP 
Sbjct: 259 NSSIMANVTKAFVG--DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPP 316

Query: 434 VCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETE 492
           +C ++K+ +  WD  + NDV + T ++ L KI+                     N  + +
Sbjct: 317 LCRRVKIQV--WDEGSMNDVALATHFIDLKKIS---------------------NEQDGD 353

Query: 493 VGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFL------- 545
            GF+PTFGP ++NLYGSPR ++   D Y E+N G GEGV++RGRILVE+A  +       
Sbjct: 354 KGFLPTFGPAWINLYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQE 412

Query: 546 ----------------------------EKTPPDKKLEPI--SNDDLLVVEKY------- 568
                                       +KT   K  +    +N   + VE +       
Sbjct: 413 SKFSKALKELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIV 472

Query: 569 -QRRRKYSLSAVFHSATML-QDVGE-AIQFEVSIGNYGNKFDTTCK-------------- 611
            ++  ++ L   F  ATM+ + +G+  I FEVSIGN+GN  D                  
Sbjct: 473 PEKNEEFLLFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDL 532

Query: 612 -----------------PLASTTQYSR-AVFDGN-YYYYLPWAHTKPVVTLTSYWEDISH 652
                            P+ASTT   +  V +GN  Y YLP+   KP V   S W D + 
Sbjct: 533 LPLLHEGQGDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTF 592

Query: 653 RLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGK 712
           RL   N L  MA+ L+ +IE ++  I  KI      E    ++ + I  +   +   E K
Sbjct: 593 RLHWSNMLEKMADFLEESIEEVRELI--KISQEAPEEKMKTVLSDFISRSSAFISEAEKK 650

Query: 713 ---ANVTVLDTQIRKLRSRSLSQIHEAA---VRMRSEATDVKSTLAEIEDWLDKLMQLTE 766
               N T LD +   L  + L  + + A   ++ + +   V   + E +++++K+  L +
Sbjct: 651 PKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVD 710

Query: 767 EPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNN 826
           EPQ+++PD+ IWM+   +R+AYARI +  +LYS       GK+CGK +T FLK P ++  
Sbjct: 711 EPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVA-GQMGKHCGKIKTHFLKPPGKRPA 769

Query: 827 GPKVPVELRVNIWLG 841
           G  V  ++ V +WLG
Sbjct: 770 GWSVQAKVDVYLWLG 784



 Score = 38.1 bits (87), Expect = 0.090
 Identities = 34/120 (28%), Positives = 51/120 (42%), Gaps = 11/120 (9%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFD---LRGIPLDFSSSLGIIV---KD 71
           G  DP   V F    + TK +   L+P WN++L F+   L G   + + S  ++V    D
Sbjct: 845 GLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYD 904

Query: 72  FETIGQNKLIGTATVALKDLTGDQSRSLP---YKLISLLNEKGQDTGATIDLVIGYDPPS 128
            + +G+ + +G    A      DQ    P   Y  I   N  G D  A  +L+    PPS
Sbjct: 905 SDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELL--QVPPS 962



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 8/77 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV--NLQIKFPSVCE------KIKL 440
           AD   L DPF +V+F      T II +  +P WNQ++  N  +    V E       + +
Sbjct: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900

Query: 441 TIYDWDRLTKNDVVGTT 457
            +YD D + K + +G T
Sbjct: 901 ELYDSDAVGKPEYLGAT 917



 Score = 32.0 bits (71), Expect = 6.4
 Identities = 23/69 (33%), Positives = 36/69 (52%), Gaps = 2/69 (2%)

Query: 21  DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD-FSSSLGIIVKDFETIGQNK 79
           DP+V++   DEKK++   +   +P +NE   FD  G  +  F   + I V   + IG + 
Sbjct: 101 DPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIG-SV 159

Query: 80  LIGTATVAL 88
           LIG+  V L
Sbjct: 160 LIGSFKVDL 168


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score =  688 bits (1775), Expect = 0.0
 Identities = 393/1039 (37%), Positives = 576/1039 (55%), Gaps = 119/1039 (11%)

Query: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260

Query: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320

Query: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 378

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 379  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 438

Query: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRF---------------- 1400
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF                
Sbjct: 439  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTG 498

Query: 1401 ----RCDPYAGKEDIVPQLKASLLSAPPCR-DIVIEMEDTKPLLASKLTEKEEE-----I 1450
                  +P    + +   +K    S    + D+  E ++ K        E EEE     +
Sbjct: 499  EVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESM 558

Query: 1451 VDWWSKFYASSG-------EHEKCGQYIQ---------------KGYSKLKIYNCELENV 1488
            +DWWSK++AS         + E  G  ++               KG  K +    E +  
Sbjct: 559  LDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKK 618

Query: 1489 AEFEG----------------------------LTDFSD---TFKLYRGKSDENEDPS-- 1515
             +  G                              +F D   TF L RGK+ ++ED S  
Sbjct: 619  TQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTE 678

Query: 1516 ---VVGEFKGSFRIY--PLPDDPSVPA----PPRQFRELPDSVPQECTVRIYIVRGLELQ 1566
               +VG FKGS  +Y  PLP+D S  A        F+ +P + P    VR+Y+VR  +L 
Sbjct: 679  EERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLH 738

Query: 1567 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1626
            P D NG  DPYI I LGK  I D+++YI   LNPVFG+ +++    P E  L ++VYD+D
Sbjct: 739  PADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWD 798

Query: 1627 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1686
                D+ +GET IDLENRF S+  + CGI + Y   G N WRD ++P+Q+L  + +    
Sbjct: 799  LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKV 858

Query: 1687 PQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQHLGAPEERLALHILRTQ-GLVPE 1740
              P     G R++   R ++      DE    K   +H+     R    I R    LVPE
Sbjct: 859  DGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE 917

Query: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800
            HVETR L +  +P I QG+L++WVD+FP  +  PG P +I+PRK KKY LRVIIWNT +V
Sbjct: 918  HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEV 977

Query: 1801 IL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1859
            +L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY SL GEGNFNWR++FPFDYL AE+
Sbjct: 978  VLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEE 1037

Query: 1860 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1919
              +++KKE  +S D+TE++IP RL +QIWD D FS DD+LG +ELDL      AK+ ++C
Sbjct: 1038 KIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQC 1097

Query: 1920 RLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV-MAGKVEMTLEILNEKEA 1978
             ++M     A   +     S+F+QK +KGWWP  A  +     + GKVE  L +L  +EA
Sbjct: 1098 TMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEA 1152

Query: 1979 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2038
            ++ P G  R+EP+    L+ PNRP+TSF+WF NP K+ ++ +W  ++W+++ LL LL+LL
Sbjct: 1153 EKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLL 1209

Query: 2039 LFVAVLLYSLPNYLSMKIV 2057
            L +A+ LYS+P YL  KI+
Sbjct: 1210 LLLALFLYSVPGYLVKKIL 1228



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 710 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 767
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 35  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 94

Query: 768 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 827
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 95  PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 153

Query: 828 P---KVPVELRVNIWLGLSAVEKKF 849
                V  ++ + +WLGLS   K+F
Sbjct: 154 SAGWTVQAKVELYLWLGLSKQRKEF 178



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 228 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 287

Query: 441 TIYDWDRLTKNDVVGTTY 458
            IYD D + K D +G T+
Sbjct: 288 EIYDQDSMGKADFMGRTF 305



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 740 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 798

Query: 447 RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478
            +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 799 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 835



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 719 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778

Query: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 779 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 813


>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317

Query: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377

Query: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 435

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 436  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 495

Query: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1416
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 496  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 552

Query: 1417 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1443
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 553  TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 612

Query: 1444 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1472
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 613  KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 672

Query: 1473 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1497
                   KG  K +    E +   +  G                              +F
Sbjct: 673  EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 732

Query: 1498 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1543
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 733  EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 792

Query: 1544 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1603
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 793  GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 852

Query: 1604 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1663
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 853  KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 912

Query: 1664 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1718
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 913  YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 971

Query: 1719 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1777
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 972  HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1031

Query: 1778 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1836
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1032 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1091

Query: 1837 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1896
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1092 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1151

Query: 1897 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1956
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1152 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1206

Query: 1957 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2015
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1207 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1263

Query: 2016 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2057
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 1264 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 710 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 767
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 92  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 151

Query: 768 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 827
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 152 PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 210

Query: 828 P---KVPVELRVNIWLGLSAVEKKF 849
                V  ++ + +WLGLS   K+F
Sbjct: 211 SAGWTVQAKVELYLWLGLSKQRKEF 235



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 285 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 344

Query: 441 TIYDWDRLTKNDVVGTTY 458
            IYD D + K D +G T+
Sbjct: 345 EIYDQDSMGKADFMGRTF 362



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 817 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 875

Query: 447 RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478
            +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 876 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 912



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 796 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 855

Query: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 856 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 890


>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007

Query: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067

Query: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 1125

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1126 IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 1185

Query: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1416
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 1186 KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 1242

Query: 1417 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1443
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 1243 TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 1302

Query: 1444 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1472
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 1303 KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 1362

Query: 1473 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1497
                   KG  K +    E +   +  G                              +F
Sbjct: 1363 EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 1422

Query: 1498 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1543
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 1423 EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 1482

Query: 1544 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1603
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 1483 GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 1542

Query: 1604 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1663
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 1543 KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 1602

Query: 1664 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1718
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 1603 YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 1661

Query: 1719 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1777
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 1662 HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1721

Query: 1778 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1836
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1722 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1781

Query: 1837 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1896
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1782 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1841

Query: 1897 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1956
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1842 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1896

Query: 1957 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2015
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1897 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1953

Query: 2016 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2057
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 1954 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995



 Score =  360 bits (925), Expect = 6e-99
 Identities = 286/954 (29%), Positives = 457/954 (47%), Gaps = 165/954 (17%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLR-----GIPLDFSSSLGIIVKDF 72
           G+ D I  V F+ +   ++ ++N       ++ +FD          +D +  L I V ++
Sbjct: 15  GRGDRIAKVTFRGQSFYSRVLEN-----CEDVADFDETFRWPVASSIDRNEMLEIQVFNY 69

Query: 73  ETIGQNKLIGTATVALKDLTGDQSRSLPYKLIS--------------------------- 105
             +  NKLIGT  + L+ +  +    +   LI                            
Sbjct: 70  SKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWD 129

Query: 106 --------LLNEKGQDTGATIDLVIGYDPPSAPHPNDLS----GPSV-------PGMGGD 146
                    L E+ +D+  T  L+ G  P S P P + S    G SV             
Sbjct: 130 DGDFLGDESLQEEEKDSQETDGLLPGSRPSSRP-PGEKSFRRAGRSVFSAMKLGKNRSHK 188

Query: 147 GEEDEGDE------DRLDNAVRGPGPKGPVGTVSEAQLARRLTKVKNSRRM-------LS 193
            E    DE      + LD+     G      +VS A +    T V N R          +
Sbjct: 189 EEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSA 248

Query: 194 NKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNN-PFFDELFFYNVNMT 252
            +P D+Q+ + VIE RQL G N+ PVV V V      T +K   N P+++E F ++ +++
Sbjct: 249 GRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVS 308

Query: 253 PSELMDEIISIRVYNSHSL-RADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSG 311
           P  + D+II I V +S +L R+  L+G FK+DVG VY +P H    KW +L+DP+D SSG
Sbjct: 309 PDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSG 368

Query: 312 SKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGI--ALRWVTFLLKIYRAED 369
            KGY+K  + V+G GD      +  + D DD+E NLLLP G+    +W  F +KIYRAE 
Sbjct: 369 LKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEG 428

Query: 370 IPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQI 429
           +P+M+ +    VK+ F G  + K+LVDP+V+V FAG+K  T++ + +  P WN+ V    
Sbjct: 429 LPRMNTSLMANVKKAFIG--ENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTD 486

Query: 430 KFPSVCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNT 488
            FP +C+++K+ I D D++  NDV +GT ++ L KI+  G                    
Sbjct: 487 LFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDG-------------------- 524

Query: 489 GETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKT 548
              + GF+PT GP ++N+YGS R YT   D + +LN G GEGV++R R+L+ LA  +  T
Sbjct: 525 ---DKGFLPTLGPAWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDT 580

Query: 549 PPDKKLEPISNDDLLVVEKYQ-------RRRKYSLSAVFHSATML--QDVGEAIQFEVSI 599
                 E  S+ ++ V +          +  ++ L   F  A+M+  ++  + I FEV+I
Sbjct: 581 ---SNPELTSSTEVQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTI 637

Query: 600 GNYGNKFDTTCKP----------------------------------LASTTQYSRAVFD 625
           GNYGN+ D   +P                                  ++ST      V D
Sbjct: 638 GNYGNEVDGLSRPQRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTD 697

Query: 626 GNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGI--QGKIP 683
            N Y++LP+   KP + + S+W D   RL   N +  +A++L+  +  ++  I  +   P
Sbjct: 698 RN-YFHLPYLERKPCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYP 756

Query: 684 ANQLAELWLKLIDEVIEDTRYTLPLT---EGKANVTVLDTQIRKLRSRSLSQIHEAAVRM 740
             +L      +++E+       L L    +G ++ T LD +  K   R L  + + A  +
Sbjct: 757 ERRLR----GVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARML 812

Query: 741 RSEAT--DVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLY 798
           R++     V+  L   +++L KL  L +EPQ+S+PDI IWM+   KR+AYAR+P+  +L+
Sbjct: 813 RAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLF 872

Query: 799 STSGENASGKYCGKTQTIFLKYPQEKNNGP---KVPVELRVNIWLGLSAVEKKF 849
           S   E  +GK C K +T+FLK P ++  G     V  ++ + +WLGLS   K+F
Sbjct: 873 SIV-EEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389  ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
            AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 975  ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 1034

Query: 441  TIYDWDRLTKNDVVGTTY 458
             IYD D + K D +G T+
Sbjct: 1035 EIYDQDSMGKADFMGRTF 1052



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 389  ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
            AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 1507 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 1565

Query: 447  RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478
             +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 1566 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 1602



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 7/89 (7%)

Query: 10  SNIPKTKFGKP----DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSL 65
           +N+ K   G+     DP V V F  +K KT    +   P+WNE + F     PL     +
Sbjct: 438 ANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPL--CKRM 495

Query: 66  GIIVKDFETIGQNKLIGTATVALKDLTGD 94
            + ++D + +  +  IGT  + L+ ++ D
Sbjct: 496 KVQIRDSDKV-NDVAIGTHFIDLRKISND 523



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193  SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
            SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 1486 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 1545

Query: 250  NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
            ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 1546 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 1580


>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score =  681 bits (1756), Expect = 0.0
 Identities = 390/1039 (37%), Positives = 575/1039 (55%), Gaps = 119/1039 (11%)

Query: 1127 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1186
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260

Query: 1187 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1242
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320

Query: 1243 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1296
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 378

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1356
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 379  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 438

Query: 1357 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRF---------------- 1400
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF                
Sbjct: 439  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTG 498

Query: 1401 ----RCDPYAGKEDIVPQLKASLLSAPPCR-DIVIEMEDTKPLLASKLTEKEEE-----I 1450
                  +P    + +   +K    S    + D+  E ++ K        E EEE     +
Sbjct: 499  EVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESM 558

Query: 1451 VDWWSKFYASSG-------EHEKCGQYIQ---------------KGYSKLKIYNCELENV 1488
            +DWWSK++AS         + E  G  ++               KG  K +    E +  
Sbjct: 559  LDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKK 618

Query: 1489 AEFEG----------------------------LTDFSD---TFKLYRGKSDENEDPS-- 1515
             +  G                              +F D   TF L RGK+ ++ED S  
Sbjct: 619  TQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTE 678

Query: 1516 ---VVGEFKGSFRIY--PLPDDPSVPA----PPRQFRELPDSVPQECTVRIYIVRGLELQ 1566
               +VG FKGS  +Y  PLP+D S  A        F+ +P + P    VR+Y+VR  +L 
Sbjct: 679  EERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLH 738

Query: 1567 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1626
            P D NG  DPYI I LGK  I D+++YI   LNPVFG+ +++    P E  L ++VYD+D
Sbjct: 739  PADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWD 798

Query: 1627 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1686
                D+ +GET IDLENRF S+  + CGI + Y   G N WRD ++P+Q+L  + +    
Sbjct: 799  LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKV 858

Query: 1687 PQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQHLGAPEERLALHILRTQ-GLVPE 1740
              P     G R++   R ++      DE    K   +H+     R    I R    LVPE
Sbjct: 859  DGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE 917

Query: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800
            HVETR L +  +P I QG+L++WVD+FP  +  PG P +I+PRK KKY LRVIIWNT +V
Sbjct: 918  HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEV 977

Query: 1801 IL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1859
            +L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY SL GEGNFNWR++FPFDYL AE+
Sbjct: 978  VLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEE 1037

Query: 1860 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1919
              +++KKE  +S D+TE++IP RL +QIWD D FS DD+LG +ELDL      AK+ ++C
Sbjct: 1038 KIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQC 1097

Query: 1920 RLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV-MAGKVEMTLEILNEKEA 1978
             ++M     A   +     S+F+QK +KGWWP  A  +     + GKVE  L +L  +EA
Sbjct: 1098 TMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEA 1152

Query: 1979 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2038
            ++ P G  R+EP+    L+ PNRP+T+F+WF NP K++K+++  R+KW+II ++  L+ L
Sbjct: 1153 EKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGL 1209

Query: 2039 LFVAVLLYSLPNYLSMKIV 2057
            L + + LYSLP Y+  K++
Sbjct: 1210 LMLGLFLYSLPGYMVKKLL 1228



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 710 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 767
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 35  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 94

Query: 768 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 827
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 95  PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 153

Query: 828 P---KVPVELRVNIWLGLSAVEKKF 849
                V  ++ + +WLGLS   K+F
Sbjct: 154 SAGWTVQAKVELYLWLGLSKQRKEF 178



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 228 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 287

Query: 441 TIYDWDRLTKNDVVGTTY 458
            IYD D + K D +G T+
Sbjct: 288 EIYDQDSMGKADFMGRTF 305



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 8/97 (8%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 740 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 798

Query: 447 RLTKNDVVGTTYLHL-----SKIAASGGEVEDFSSSG 478
            +  +D++G T + L     SK  A+ G  + +S+ G
Sbjct: 799 LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 835



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 719 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778

Query: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 779 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 813


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 1557 IYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1613
            + I++ L+L  +D+NG  DPY+KI L    KK  + + H    TLNPVF   ++ S  L 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH--RKTLNPVFNETFQFSVPLA 375

Query: 1614 Q--EKDLKISVYDYDTFTRDEKVGETIID 1640
            +  ++ L  SVYD+D F+R + +G+ ++D
Sbjct: 376  ELAQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 54/336 (16%)

Query: 1123 GANTPIVSCNFDRVYIY---HLRCYVYQARNLLALDKDSFSDPYAHICFLHRSK---TTE 1176
            G   P    +F   Y+Y    L   + QA +L A D + FSDPY  I  L   K    T+
Sbjct: 295  GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            +   TLNP      +F+E   +  P   L    K+   ++D D+  + + +G+ +   ++
Sbjct: 355  VHRKTLNP------VFNETFQFSVPLAELAQ-RKLHFSVYDFDRFSRHDLIGQVVLDNLL 407

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQG 1296
            +L  +    P  LW  ++ G     D+         G+   +L  LP             
Sbjct: 408  ELAEQPPDRP--LWRDIVEGGSEKADL---------GELNFSLCYLP------------- 443

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSP----SLVVECGGERVESVVIKNLKKTPNF 1352
                 +LT   I A    N+K   +   + P    SL+ E    +     IK     P +
Sbjct: 444  --TAGRLTVTIIKA---SNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTY 498

Query: 1353 PSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIV 1412
              +++F    +  E +    L I V+D+   G   V+G C   R+     DP+ G+E   
Sbjct: 499  NEALVF---DVAPESVENVGLSIAVVDYDCIGHNEVIGVC---RVGPDAADPH-GREHWA 551

Query: 1413 PQLKASLLSAPPCRDIVIEMEDTKPLLASK-LTEKE 1447
              L            +V E   T     SK L+EKE
Sbjct: 552  EMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKE 587



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 43/185 (23%), Positives = 81/185 (43%), Gaps = 22/185 (11%)

Query: 390 DKKNLVDPFVEVSFAG---KKVCTNIIEKNANPEWNQVVNLQIKFPSVCE-KIKLTIYDW 445
           D     DP+V++       KK  T +  K  NP +N+     +    + + K+  ++YD+
Sbjct: 330 DSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDF 389

Query: 446 DRLTKNDVVGTTYL-HLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVG--FVPTFGPC 502
           DR +++D++G   L +L ++A    +   +     G  S   + GE      ++PT G  
Sbjct: 390 DRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEG-GSEKADLGELNFSLCYLPTAGRL 448

Query: 503 YLNLYGSPR----EYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPIS 558
            + +  +      + TGF DPY + +      +   GR L +  T ++K      L P  
Sbjct: 449 TVTIIKASNLKAMDLTGFSDPYVKAS------LISEGRRLKKRKTSIKK----NTLNPTY 498

Query: 559 NDDLL 563
           N+ L+
Sbjct: 499 NEALV 503



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 2   LRVIVESASNIPKTKF-GKPDPIVSVIFKDE-----KKKTKKVDNELNPVWNEILEFDLR 55
           L V +  ASN+      G  DP V      E     K+KT    N LNP +NE L FD+ 
Sbjct: 448 LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVA 507

Query: 56  GIPLDFSSSLGIIVKDFETIGQNKLIGTATV 86
              ++ +  L I V D++ IG N++IG   V
Sbjct: 508 PESVE-NVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 1549 VPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGR- 1604
            +P    + + I++   L+  D  G  DPY+K +L   G+++ + +     NTLNP +   
Sbjct: 442  LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEA 501

Query: 1605 -MYELSCYLPQEKDLKISVYDYDTFTRDEKVG 1635
             +++++    +   L I+V DYD    +E +G
Sbjct: 502  LVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 2   LRVIVESASNIP-KTKFGKPDPIVSV-IFKDEKKK--TKKVDNELNPVWNEILEFDLRGI 57
           L V +  A ++P K   G  DP V + +  D KKK  TK     LNPV+NE  +F +   
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 58  PLDFSSSLGIIVKDFETIGQNKLIG 82
            L     L   V DF+   ++ LIG
Sbjct: 376 EL-AQRKLHFSVYDFDRFSRHDLIG 399


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 1557 IYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1613
            + I++ L+L  +D+NG  DPY+KI L    KK  + + H    TLNPVF   ++ S  L 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH--RKTLNPVFNETFQFSVPLA 375

Query: 1614 Q--EKDLKISVYDYDTFTRDEKVGETIID 1640
            +  ++ L  SVYD+D F+R + +G+ ++D
Sbjct: 376  ELAQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 54/336 (16%)

Query: 1123 GANTPIVSCNFDRVYIY---HLRCYVYQARNLLALDKDSFSDPYAHICFLHRSK---TTE 1176
            G   P    +F   Y+Y    L   + QA +L A D + FSDPY  I  L   K    T+
Sbjct: 295  GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            +   TLNP      +F+E   +  P   L    K+   ++D D+  + + +G+ +   ++
Sbjct: 355  VHRKTLNP------VFNETFQFSVPLAELAQ-RKLHFSVYDFDRFSRHDLIGQVVLDNLL 407

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQG 1296
            +L  +    P  LW  ++ G     D+         G+   +L  LP             
Sbjct: 408  ELAEQPPDRP--LWRDIVEGGSEKADL---------GELNFSLCYLP------------- 443

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSP----SLVVECGGERVESVVIKNLKKTPNF 1352
                 +LT   I A    N+K   +   + P    SL+ E    +     IK     P +
Sbjct: 444  --TAGRLTVTIIKA---SNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTY 498

Query: 1353 PSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIV 1412
              +++F    +  E +    L I V+D+   G   V+G C   R+     DP+ G+E   
Sbjct: 499  NEALVF---DVAPESVENVGLSIAVVDYDCIGHNEVIGVC---RVGPDAADPH-GREHWA 551

Query: 1413 PQLKASLLSAPPCRDIVIEMEDTKPLLASK-LTEKE 1447
              L            +V E   T     SK L+EKE
Sbjct: 552  EMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKE 587



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 43/185 (23%), Positives = 81/185 (43%), Gaps = 22/185 (11%)

Query: 390 DKKNLVDPFVEVSFAG---KKVCTNIIEKNANPEWNQVVNLQIKFPSVCE-KIKLTIYDW 445
           D     DP+V++       KK  T +  K  NP +N+     +    + + K+  ++YD+
Sbjct: 330 DSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDF 389

Query: 446 DRLTKNDVVGTTYL-HLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVG--FVPTFGPC 502
           DR +++D++G   L +L ++A    +   +     G  S   + GE      ++PT G  
Sbjct: 390 DRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEG-GSEKADLGELNFSLCYLPTAGRL 448

Query: 503 YLNLYGSPR----EYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPIS 558
            + +  +      + TGF DPY + +      +   GR L +  T ++K      L P  
Sbjct: 449 TVTIIKASNLKAMDLTGFSDPYVKAS------LISEGRRLKKRKTSIKK----NTLNPTY 498

Query: 559 NDDLL 563
           N+ L+
Sbjct: 499 NEALV 503



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 2   LRVIVESASNIPKTKF-GKPDPIVSVIFKDE-----KKKTKKVDNELNPVWNEILEFDLR 55
           L V +  ASN+      G  DP V      E     K+KT    N LNP +NE L FD+ 
Sbjct: 448 LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVA 507

Query: 56  GIPLDFSSSLGIIVKDFETIGQNKLIGTATV 86
              ++ +  L I V D++ IG N++IG   V
Sbjct: 508 PESVE-NVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 1549 VPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGR- 1604
            +P    + + I++   L+  D  G  DPY+K +L   G+++ + +     NTLNP +   
Sbjct: 442  LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEA 501

Query: 1605 -MYELSCYLPQEKDLKISVYDYDTFTRDEKVG 1635
             +++++    +   L I+V DYD    +E +G
Sbjct: 502  LVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 2   LRVIVESASNIP-KTKFGKPDPIVSV-IFKDEKKK--TKKVDNELNPVWNEILEFDLRGI 57
           L V +  A ++P K   G  DP V + +  D KKK  TK     LNPV+NE  +F +   
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 58  PLDFSSSLGIIVKDFETIGQNKLIG 82
            L     L   V DF+   ++ LIG
Sbjct: 376 EL-AQRKLHFSVYDFDRFSRHDLIG 399


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 1557 IYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1613
            + I++ L+L  +D+NG  DPY+KI L    KK  + + H    TLNPVF   ++ S  L 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH--RKTLNPVFNETFQFSVPLA 375

Query: 1614 Q--EKDLKISVYDYDTFTRDEKVGETIID 1640
            +  ++ L  SVYD+D F+R + +G+ ++D
Sbjct: 376  ELAQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 54/336 (16%)

Query: 1123 GANTPIVSCNFDRVYIY---HLRCYVYQARNLLALDKDSFSDPYAHICFLHRSK---TTE 1176
            G   P    +F   Y+Y    L   + QA +L A D + FSDPY  I  L   K    T+
Sbjct: 295  GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

Query: 1177 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1236
            +   TLNP      +F+E   +  P   L    K+   ++D D+  + + +G+ +   ++
Sbjct: 355  VHRKTLNP------VFNETFQFSVPLAELAQ-RKLHFSVYDFDRFSRHDLIGQVVLDNLL 407

Query: 1237 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQG 1296
            +L  +    P  LW  ++ G     D+         G+   +L  LP             
Sbjct: 408  ELAEQPPDRP--LWRDIVEGGSEKADL---------GELNFSLCYLP------------- 443

Query: 1297 IRPVVQLTAIEILAWGLRNMKNFQMASITSP----SLVVECGGERVESVVIKNLKKTPNF 1352
                 +LT   I A    N+K   +   + P    SL+ E    +     IK     P +
Sbjct: 444  --TAGRLTVTIIKA---SNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTY 498

Query: 1353 PSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIV 1412
              +++F    +  E +    L I V+D+   G   V+G C   R+     DP+ G+E   
Sbjct: 499  NEALVF---DVAPESVENVGLSIAVVDYDCIGHNEVIGVC---RVGPDAADPH-GREHWA 551

Query: 1413 PQLKASLLSAPPCRDIVIEMEDTKPLLASK-LTEKE 1447
              L            +V E   T     SK L+EKE
Sbjct: 552  EMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKE 587



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 43/185 (23%), Positives = 81/185 (43%), Gaps = 22/185 (11%)

Query: 390 DKKNLVDPFVEVSFAG---KKVCTNIIEKNANPEWNQVVNLQIKFPSVCE-KIKLTIYDW 445
           D     DP+V++       KK  T +  K  NP +N+     +    + + K+  ++YD+
Sbjct: 330 DSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDF 389

Query: 446 DRLTKNDVVGTTYL-HLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVG--FVPTFGPC 502
           DR +++D++G   L +L ++A    +   +     G  S   + GE      ++PT G  
Sbjct: 390 DRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEG-GSEKADLGELNFSLCYLPTAGRL 448

Query: 503 YLNLYGSPR----EYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPIS 558
            + +  +      + TGF DPY + +      +   GR L +  T ++K      L P  
Sbjct: 449 TVTIIKASNLKAMDLTGFSDPYVKAS------LISEGRRLKKRKTSIKK----NTLNPTY 498

Query: 559 NDDLL 563
           N+ L+
Sbjct: 499 NEALV 503



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 2   LRVIVESASNIPKTKF-GKPDPIVSVIFKDE-----KKKTKKVDNELNPVWNEILEFDLR 55
           L V +  ASN+      G  DP V      E     K+KT    N LNP +NE L FD+ 
Sbjct: 448 LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVA 507

Query: 56  GIPLDFSSSLGIIVKDFETIGQNKLIGTATV 86
              ++ +  L I V D++ IG N++IG   V
Sbjct: 508 PESVE-NVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 1549 VPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGR- 1604
            +P    + + I++   L+  D  G  DPY+K +L   G+++ + +     NTLNP +   
Sbjct: 442  LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEA 501

Query: 1605 -MYELSCYLPQEKDLKISVYDYDTFTRDEKVG 1635
             +++++    +   L I+V DYD    +E +G
Sbjct: 502  LVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 2   LRVIVESASNIP-KTKFGKPDPIVSV-IFKDEKKK--TKKVDNELNPVWNEILEFDLRGI 57
           L V +  A ++P K   G  DP V + +  D KKK  TK     LNPV+NE  +F +   
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 58  PLDFSSSLGIIVKDFETIGQNKLIG 82
            L     L   V DF+   ++ LIG
Sbjct: 376 EL-AQRKLHFSVYDFDRFSRHDLIG 399


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 44/124 (35%), Positives = 61/124 (49%), Gaps = 14/124 (11%)

Query: 1138 IYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEI 1197
            I  L  +V +A  L A   +  S+PY  I    +S TT  I  TLNP W+    F   ++
Sbjct: 1541 IGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDL 1600

Query: 1198 YGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMD----ITPKLLWHPV 1253
            Y   Q VL       + LFD DQ   D+FLGR+   PV K+ +E +    +T +LL H V
Sbjct: 1601 Y---QDVL------CLTLFDRDQFSPDDFLGRTEI-PVAKIRTEQESKGPMTRRLLLHEV 1650

Query: 1254 MNGD 1257
              G+
Sbjct: 1651 PTGE 1654



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 396  DPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIK-LTIYDWDRLTKNDVV 454
            +P+ E+S   +   T  I+   NP+WN   N Q     + + +  LT++D D+ + +D +
Sbjct: 1564 NPYCEISMGSQSYTTRTIQDTLNPKWN--FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFL 1621

Query: 455  GTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGF 495
            G T + ++KI     E E           + V TGE  V F
Sbjct: 1622 GRTEIPVAKIRT---EQESKGPMTRRLLLHEVPTGEVWVRF 1659


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 44/124 (35%), Positives = 61/124 (49%), Gaps = 14/124 (11%)

Query: 1138 IYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEI 1197
            I  L  +V +A  L A   +  S+PY  I    +S TT  I  TLNP W+    F   ++
Sbjct: 1568 IGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDL 1627

Query: 1198 YGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMD----ITPKLLWHPV 1253
            Y   Q VL       + LFD DQ   D+FLGR+   PV K+ +E +    +T +LL H V
Sbjct: 1628 Y---QDVL------CLTLFDRDQFSPDDFLGRTEI-PVAKIRTEQESKGPMTRRLLLHEV 1677

Query: 1254 MNGD 1257
              G+
Sbjct: 1678 PTGE 1681



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 6/101 (5%)

Query: 396  DPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIK-LTIYDWDRLTKNDVV 454
            +P+ E+S   +   T  I+   NP+WN   N Q     + + +  LT++D D+ + +D +
Sbjct: 1591 NPYCEISMGSQSYTTRTIQDTLNPKWN--FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFL 1648

Query: 455  GTTYLHLSKIAASGGEVEDFSSSGTGAASYTVNTGETEVGF 495
            G T + ++KI     E E           + V TGE  V F
Sbjct: 1649 GRTEIPVAKIRT---EQESKGPMTRRLLLHEVPTGEVWVRF 1686


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
            sapiens]
          Length = 778

 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 4/98 (4%)

Query: 1555 VRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQ 1614
            V I ++ G +L+  D+NGL DPY+K  LG +  + +   +P TLNP +   ++   Y  +
Sbjct: 251  VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSK--IMPKTLNPQWREQFDFHLYEER 308

Query: 1615 EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSH 1652
               + I+ +D D   RD+ +G   +DL    LSR  +H
Sbjct: 309  GGVIDITAWDKDAGKRDDFIGRCQVDLS--ALSREQTH 344



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 36/107 (33%), Positives = 53/107 (49%), Gaps = 6/107 (5%)

Query: 1544 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1603
            E+P + P    + I + RG  L  +D  G  DPY+K  +G K +  R   I   LNPV+ 
Sbjct: 31   EVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEV-FRSKIIHKNLNPVW- 88

Query: 1604 RMYELSCYLPQ--EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSR 1648
               E +C L     + L I V+DYD   +D+ +G   +DL    L+R
Sbjct: 89   --EEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNR 133



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 65/278 (23%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 201 IRVRVIEGRQLSGNNIR----PVVKVHVCGQTHRTRIK-RGNNPFFDELFFYNVNMTPSE 255
           + + +IEGR L   +      P VK  +  Q ++++I  +  NP + E F +++     E
Sbjct: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLY----E 306

Query: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED-------- 307
               +I I  ++  + + D  +G  ++D+  +  E  H +    L L + E         
Sbjct: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLE---LQLEEGEGHLVLLVTL 363

Query: 308 TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFL-LKIYR 366
           T+S +     +S+  L           D+    + ++    L     L+ V FL +K+ R
Sbjct: 364 TASATVSISDLSVNSL----------EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIR 413

Query: 367 AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
           AE +                  AD     DPF  V     ++ T+ + KN NPEWN+V  
Sbjct: 414 AEGLMA----------------ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFT 457

Query: 427 LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKI 464
             IK   +   +++T+YD DR    D +G   + L  I
Sbjct: 458 FNIK--DIHSVLEVTVYDEDRDRSADFLGKVAIPLLSI 493



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 9/83 (10%)

Query: 1147 QARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQ 1206
            + R+L A+D +  SDPY      H+   ++I+  TLNP W +   F    +Y E   V+ 
Sbjct: 257  EGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDF---HLYEERGGVID 313

Query: 1207 NPPKVIMELFDNDQVGKDEFLGR 1229
                  +  +D D   +D+F+GR
Sbjct: 314  ------ITAWDKDAGKRDDFIGR 330



 Score = 41.2 bits (95), Expect = 0.011
 Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 3/76 (3%)

Query: 390 DKKNLVDPFVEVSFAGKKVC-TNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRL 448
           D+    DP+V+    GK+V  + II KN NP W +   + +    + E + + ++D+D  
Sbjct: 56  DRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILV--DHLREPLYIKVFDYDFG 113

Query: 449 TKNDVVGTTYLHLSKI 464
            ++D +G+ +L L+++
Sbjct: 114 LQDDFMGSAFLDLTQL 129



 Score = 38.5 bits (88), Expect = 0.069
 Identities = 33/115 (28%), Positives = 55/115 (47%), Gaps = 22/115 (19%)

Query: 1138 IYHLRCYVYQARNLLALDKDSFSDPYAHICF----LHRSKTTEIIHSTLNPTWDQ--TII 1191
            +Y L   + + ++L A D+   SDPY         + RSK   IIH  LNP W++   I+
Sbjct: 39   MYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK---IIHKNLNPVWEEKACIL 95

Query: 1192 FDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFS-PVVKLNSEMDIT 1245
             D +    EP         + +++FD D   +D+F+G +      ++LN   D+T
Sbjct: 96   VDHLR---EP---------LYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 23/89 (25%), Positives = 44/89 (49%), Gaps = 10/89 (11%)

Query: 1141 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1200
            L+  V +A  L+A D    SDP+  +   +    T  ++  LNP W++   F+  +I+  
Sbjct: 407  LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIH-- 464

Query: 1201 PQTVLQNPPKVIMELFDNDQVGKDEFLGR 1229
              +VL+      + ++D D+    +FLG+
Sbjct: 465  --SVLE------VTVYDEDRDRSADFLGK 485



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQ 77
           GK DP   V   +++  T  V   LNP WN++  F+++    D  S L + V D +    
Sbjct: 424 GKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIK----DIHSVLEVTVYDEDRDRS 479

Query: 78  NKLIGTATVALKDLTGDQSRSLPYK 102
              +G   + L  +   + ++   K
Sbjct: 480 ADFLGKVAIPLLSIQNGEQKAYVLK 504



 Score = 36.2 bits (82), Expect = 0.34
 Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 390 DKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLT 449
           D   L DP+V+     +K  + I+ K  NP+W +  +  + +      I +T +D D   
Sbjct: 265 DSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL-YEERGGVIDITAWDKDAGK 323

Query: 450 KNDVVGTTYLHLSKIA 465
           ++D +G   + LS ++
Sbjct: 324 RDDFIGRCQVDLSALS 339



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 9/89 (10%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDL---RGIPLDFSSSLGIIVKDFET 74
           G  DP V      +K K+K +   LNP W E  +F L   RG  +D      I   D + 
Sbjct: 268 GLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVID------ITAWDKDA 321

Query: 75  IGQNKLIGTATVALKDLTGDQSRSLPYKL 103
             ++  IG   V L  L+ +Q+  L  +L
Sbjct: 322 GKRDDFIGRCQVDLSALSREQTHKLELQL 350


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
            sapiens]
          Length = 999

 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 4/98 (4%)

Query: 1555 VRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQ 1614
            V I ++ G +L+  D+NGL DPY+K  LG +  + +   +P TLNP +   ++   Y  +
Sbjct: 472  VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSK--IMPKTLNPQWREQFDFHLYEER 529

Query: 1615 EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSH 1652
               + I+ +D D   RD+ +G   +DL    LSR  +H
Sbjct: 530  GGVIDITAWDKDAGKRDDFIGRCQVDLS--ALSREQTH 565



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 36/107 (33%), Positives = 53/107 (49%), Gaps = 6/107 (5%)

Query: 1544 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1603
            E+P + P    + I + RG  L  +D  G  DPY+K  +G K +  R   I   LNPV+ 
Sbjct: 252  EVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEV-FRSKIIHKNLNPVW- 309

Query: 1604 RMYELSCYLPQ--EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSR 1648
               E +C L     + L I V+DYD   +D+ +G   +DL    L+R
Sbjct: 310  --EEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNR 354



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 65/278 (23%), Positives = 115/278 (41%), Gaps = 49/278 (17%)

Query: 201 IRVRVIEGRQLSGNNIR----PVVKVHVCGQTHRTRIK-RGNNPFFDELFFYNVNMTPSE 255
           + + +IEGR L   +      P VK  +  Q ++++I  +  NP + E F +++     E
Sbjct: 472 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLY----E 527

Query: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED-------- 307
               +I I  ++  + + D  +G  ++D+  +  E  H +    L L + E         
Sbjct: 528 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLE---LQLEEGEGHLVLLVTL 584

Query: 308 TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFL-LKIYR 366
           T+S +     +S+  L           D+    + ++    L     L+ V FL +K+ R
Sbjct: 585 TASATVSISDLSVNSL----------EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIR 634

Query: 367 AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
           AE +                  AD     DPF  V     ++ T+ + KN NPEWN+V  
Sbjct: 635 AEGLMA----------------ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFT 678

Query: 427 LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKI 464
             IK   +   +++T+YD DR    D +G   + L  I
Sbjct: 679 FNIK--DIHSVLEVTVYDEDRDRSADFLGKVAIPLLSI 714



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 9/83 (10%)

Query: 1147 QARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQ 1206
            + R+L A+D +  SDPY      H+   ++I+  TLNP W +   F    +Y E   V+ 
Sbjct: 478  EGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDF---HLYEERGGVID 534

Query: 1207 NPPKVIMELFDNDQVGKDEFLGR 1229
                  +  +D D   +D+F+GR
Sbjct: 535  ------ITAWDKDAGKRDDFIGR 551



 Score = 41.2 bits (95), Expect = 0.011
 Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 3/76 (3%)

Query: 390 DKKNLVDPFVEVSFAGKKVC-TNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRL 448
           D+    DP+V+    GK+V  + II KN NP W +   + +    + E + + ++D+D  
Sbjct: 277 DRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILV--DHLREPLYIKVFDYDFG 334

Query: 449 TKNDVVGTTYLHLSKI 464
            ++D +G+ +L L+++
Sbjct: 335 LQDDFMGSAFLDLTQL 350



 Score = 38.9 bits (89), Expect = 0.053
 Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 27/149 (18%)

Query: 1104 EDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPY 1163
            E G+E    ++  +      A  P+         +Y L   + + ++L A D+   SDPY
Sbjct: 231  ETGEEHGSSQKIINTAGTSNAEVPLADPG-----MYQLDITLRRGQSLAARDRGGTSDPY 285

Query: 1164 AHICF----LHRSKTTEIIHSTLNPTWDQ--TIIFDEVEIYGEPQTVLQNPPKVIMELFD 1217
                     + RSK   IIH  LNP W++   I+ D +    EP         + +++FD
Sbjct: 286  VKFKIGGKEVFRSK---IIHKNLNPVWEEKACILVDHLR---EP---------LYIKVFD 330

Query: 1218 NDQVGKDEFLGRSIFS-PVVKLNSEMDIT 1245
             D   +D+F+G +      ++LN   D+T
Sbjct: 331  YDFGLQDDFMGSAFLDLTQLELNRPTDVT 359



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 23/89 (25%), Positives = 44/89 (49%), Gaps = 10/89 (11%)

Query: 1141 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1200
            L+  V +A  L+A D    SDP+  +   +    T  ++  LNP W++   F+  +I+  
Sbjct: 628  LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIH-- 685

Query: 1201 PQTVLQNPPKVIMELFDNDQVGKDEFLGR 1229
              +VL+      + ++D D+    +FLG+
Sbjct: 686  --SVLE------VTVYDEDRDRSADFLGK 706



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQ 77
           GK DP   V   +++  T  V   LNP WN++  F+++    D  S L + V D +    
Sbjct: 645 GKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIK----DIHSVLEVTVYDEDRDRS 700

Query: 78  NKLIGTATVALKDLTGDQSRSLPYK 102
              +G   + L  +   + ++   K
Sbjct: 701 ADFLGKVAIPLLSIQNGEQKAYVLK 725



 Score = 36.2 bits (82), Expect = 0.34
 Identities = 19/76 (25%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 390 DKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLT 449
           D   L DP+V+     +K  + I+ K  NP+W +  +  + +      I +T +D D   
Sbjct: 486 DSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL-YEERGGVIDITAWDKDAGK 544

Query: 450 KNDVVGTTYLHLSKIA 465
           ++D +G   + LS ++
Sbjct: 545 RDDFIGRCQVDLSALS 560



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 9/89 (10%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDL---RGIPLDFSSSLGIIVKDFET 74
           G  DP V      +K K+K +   LNP W E  +F L   RG  +D      I   D + 
Sbjct: 489 GLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVID------ITAWDKDA 542

Query: 75  IGQNKLIGTATVALKDLTGDQSRSLPYKL 103
             ++  IG   V L  L+ +Q+  L  +L
Sbjct: 543 GKRDDFIGRCQVDLSALSREQTHKLELQL 571


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,662,745
Number of Sequences: 37866
Number of extensions: 4263574
Number of successful extensions: 12821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 11313
Number of HSP's gapped (non-prelim): 984
length of query: 2061
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1943
effective length of database: 13,779,330
effective search space: 26773238190
effective search space used: 26773238190
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.