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Search of human proteins with 71979667
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71979667 growth factor receptor-bound protein 7 [Homo
sapiens]
(532 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens] 1096 0.0
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens] 1096 0.0
gi|48762697 growth factor receptor-bound protein 10 isoform c [H... 550 e-157
gi|48762695 growth factor receptor-bound protein 10 isoform c [H... 550 e-157
gi|48762679 growth factor receptor-bound protein 10 isoform a [H... 550 e-157
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens] 495 e-140
gi|48762693 growth factor receptor-bound protein 10 isoform b [H... 468 e-132
gi|47132519 Ras association and pleckstrin homology domains 1 is... 143 4e-34
gi|42740893 Ras association and pleckstrin homology domains 1 is... 143 4e-34
gi|56118221 amyloid beta (A4) precursor protein-binding, family ... 142 1e-33
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 55 2e-07
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 55 2e-07
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 55 2e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 53 8e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 53 8e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 53 8e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 52 2e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 52 2e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 52 2e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 52 2e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 52 2e-06
gi|187475373 c-src tyrosine kinase [Homo sapiens] 51 2e-06
gi|4758078 c-src tyrosine kinase [Homo sapiens] 51 2e-06
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 51 3e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 50 4e-06
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 50 4e-06
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 49 1e-05
gi|194239668 SHC (Src homology 2 domain containing) transforming... 49 1e-05
gi|194239664 SHC (Src homology 2 domain containing) transforming... 49 1e-05
gi|194239662 SHC (Src homology 2 domain containing) transforming... 49 1e-05
>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
Length = 532
Score = 1096 bits (2834), Expect = 0.0
Identities = 532/532 (100%), Positives = 532/532 (100%)
Query: 1 MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR
Sbjct: 1 MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60
Query: 61 ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120
ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA
Sbjct: 61 ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120
Query: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180
GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
Sbjct: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180
Query: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG
Sbjct: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240
Query: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300
SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
Sbjct: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300
Query: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360
FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG
Sbjct: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360
Query: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420
SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS
Sbjct: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420
Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY
Sbjct: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Sbjct: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
Length = 532
Score = 1096 bits (2834), Expect = 0.0
Identities = 532/532 (100%), Positives = 532/532 (100%)
Query: 1 MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR
Sbjct: 1 MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60
Query: 61 ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120
ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA
Sbjct: 61 ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120
Query: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180
GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
Sbjct: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180
Query: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240
FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG
Sbjct: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240
Query: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300
SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
Sbjct: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300
Query: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360
FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG
Sbjct: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360
Query: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420
SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS
Sbjct: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420
Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY
Sbjct: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Sbjct: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
sapiens]
Length = 536
Score = 550 bits (1418), Expect = e-157
Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)
Query: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC
Sbjct: 32 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 89
Query: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H
Sbjct: 90 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 144
Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
+ D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P
Sbjct: 145 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 201
Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
+ FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS
Sbjct: 202 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 259
Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR
Sbjct: 260 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 319
Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
+ C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD
Sbjct: 320 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 378
Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG
Sbjct: 379 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 438
Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 439 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 498
Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
+DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 499 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536
>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
sapiens]
Length = 536
Score = 550 bits (1418), Expect = e-157
Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)
Query: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC
Sbjct: 32 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 89
Query: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H
Sbjct: 90 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 144
Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
+ D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P
Sbjct: 145 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 201
Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
+ FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS
Sbjct: 202 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 259
Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR
Sbjct: 260 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 319
Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
+ C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD
Sbjct: 320 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 378
Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG
Sbjct: 379 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 438
Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 439 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 498
Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
+DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 499 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536
>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
sapiens]
Length = 594
Score = 550 bits (1418), Expect = e-157
Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)
Query: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC
Sbjct: 90 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147
Query: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H
Sbjct: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202
Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
+ D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P
Sbjct: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259
Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
+ FPE+MV+ C ++ S L+QNFLN+ S PEIQGFL ++ G+K WK+ + LRRS
Sbjct: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317
Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
GLY STKGTSK+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR
Sbjct: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377
Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
+ C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD
Sbjct: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436
Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG
Sbjct: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496
Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556
Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
+DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594
>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
Length = 540
Score = 495 bits (1275), Expect = e-140
Identities = 246/483 (50%), Positives = 337/483 (69%), Gaps = 13/483 (2%)
Query: 55 REEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRP-HVVKVYSEDGAC 113
++++ +PSIPNPFPELC P S + + L P+ SR V+KVYSED
Sbjct: 66 KKKDLDVPEMPSIPNPFPELCCSPFTSVL------SADLFPKANSRKKQVIKVYSEDETS 119
Query: 114 RSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPV 173
R+++V + TAR VC++L+ + H + D +W L E PH+ +ER +EDHE V+EV + W +
Sbjct: 120 RALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGI 179
Query: 174 GGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQ 233
+++ FRKN+AKYE FK+ P FPE MVS + + IS ++Q FL++ ++PEI
Sbjct: 180 EEENKLYFRKNYAKYEFFKN-PMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIH 238
Query: 234 GFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLY 293
GFL + G+K WK+ + FLRRSGLY+STKGTSK+PRHLQ+ ++ S++YV G+K +
Sbjct: 239 GFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKH 298
Query: 294 GMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRH 353
G PT++GFC KPNK G + L++ C+E+EQSRTCW+ A RL KYG+QLY+NY
Sbjct: 299 GAPTNYGFCFKPNKA-GGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGR 357
Query: 354 LHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLP 413
S P+RS S+N+LVAMDFSG RVIENP EALSVA+EE AWRKK RL
Sbjct: 358 SGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTH 417
Query: 414 MPASGTSLSAA----IHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
+ +S S+A IHR+Q WFH +ISR+E+QRLI QQGLVDG+FLVR+SQ NP+ FVL
Sbjct: 418 GSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVL 477
Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529
S+ H QK+KH+ I+P E++G ++ ++DDG TRFTDL+QLVEF+QLN+G+LPC L+H C R
Sbjct: 478 SMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 537
Query: 530 VAL 532
+AL
Sbjct: 538 IAL 540
>gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo
sapiens]
Length = 548
Score = 468 bits (1204), Expect = e-132
Identities = 253/518 (48%), Positives = 336/518 (64%), Gaps = 63/518 (12%)
Query: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
P PP + +P +P + V+RSQP+ I R+L+EE++ R +SLP+IPNPFPELC
Sbjct: 90 PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147
Query: 77 PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
P S + G L P A+ VKV+SEDG + VE+ A TAR +C++LV ++H
Sbjct: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202
Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
+ D +W LVE HPHL LER LEDHE VV+V++ + +S+F+FRKN+AKYE FK+ P
Sbjct: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259
Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
+ FPE+MV+ C ++ S L+Q
Sbjct: 260 NFFPEQMVTWCQQSNG--SQTQLLQ----------------------------------- 282
Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
+PRHLQ +AD+ +SN++ + GRK Y PTD G C+KPNK+RN K LR
Sbjct: 283 -----------EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 331
Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
+ C+EDEQ+RTCW+ AFRL KYG+ LY+NY+ Q R S S P+RS S+N+LVAMD
Sbjct: 332 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 390
Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
FSG GRVIENP EA S ALEE AWRK++ L P ++LS IHRTQ WFHG
Sbjct: 391 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 450
Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 451 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 510
Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
+DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 511 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 548
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 143 bits (360), Expect = 4e-34
Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)
Query: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162
V++V+ D + +++ V T R V + L+ ++H W LVE L +ER EDHE
Sbjct: 272 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 331
Query: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222
++VE W ++ +F + KY LFK+ + L +K + D + + E+
Sbjct: 332 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 391
Query: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282
++ + PEI+G L L+ G+K WK+ + LR SG+YY KG +K R L ++ N
Sbjct: 392 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 449
Query: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342
VY R Y PTD+ +K +++ + ++ C +D ++ W+ R+ KYG QL
Sbjct: 450 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 509
Query: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383
Y NYQ+A R + L S ++S S ++ + S H+ +
Sbjct: 510 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 553
Score = 31.2 bits (69), Expect = 2.5
Identities = 21/69 (30%), Positives = 28/69 (40%), Gaps = 9/69 (13%)
Query: 19 PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPP 78
P P TPP P P+P V P P K + + SIP P P+ PP
Sbjct: 870 PPPPTPPAMESQPLKPVPANVAPQSP---PAVKAKPKWQP------SSIPVPSPDFPPPP 920
Query: 79 SQSPILGGP 87
+S ++ P
Sbjct: 921 PESSLVFPP 929
Score = 29.3 bits (64), Expect = 9.4
Identities = 12/29 (41%), Positives = 14/29 (48%)
Query: 8 PHLSSSPEDLCPAPGTPPGTPRPPDTPLP 36
P+ +S P P P PP P PP P P
Sbjct: 618 PYTASQPSPPLPPPPPPPPPPPPPPPPPP 646
Score = 29.3 bits (64), Expect = 9.4
Identities = 27/109 (24%), Positives = 43/109 (39%), Gaps = 19/109 (17%)
Query: 6 SPPHLSSS---PEDLCPAPGTPPGTPRPPDTPLP-EEVKRSQP---------LLIPTTGR 52
+PP + S P+ L P G P P PP P P + + +P P
Sbjct: 688 TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747
Query: 53 KLREEERRATSLPSIPNPFPELCSP-PSQSP-----ILGGPSSARGLLP 95
K+ + + P P P P + +P P Q+P + P+S + + P
Sbjct: 748 KIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAP 796
>gi|42740893 Ras association and pleckstrin homology domains 1
isoform 3 [Homo sapiens]
Length = 644
Score = 143 bits (360), Expect = 4e-34
Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)
Query: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162
V++V+ D + +++ V T R V + L+ ++H W LVE L +ER EDHE
Sbjct: 324 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 383
Query: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222
++VE W ++ +F + KY LFK+ + L +K + D + + E+
Sbjct: 384 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 443
Query: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282
++ + PEI+G L L+ G+K WK+ + LR SG+YY KG +K R L ++ N
Sbjct: 444 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 501
Query: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342
VY R Y PTD+ +K +++ + ++ C +D ++ W+ R+ KYG QL
Sbjct: 502 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 561
Query: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383
Y NYQ+A R + L S ++S S ++ + S H+ +
Sbjct: 562 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 605
>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
member 1 interacting protein [Homo sapiens]
Length = 666
Score = 142 bits (357), Expect = 1e-33
Identities = 80/255 (31%), Positives = 132/255 (51%), Gaps = 5/255 (1%)
Query: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162
VVKV+ D + +S+ V AR V + L ++ H + W L E +P L +ER EDHE
Sbjct: 179 VVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHE 238
Query: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGIS---HEDL 219
+VVEV + W +++ +F + KY +FK+ + + + + ++ E L
Sbjct: 239 NVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESL 298
Query: 220 IQNFLNAGSF--PEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVAD 277
++ S PE++G L L+ G+K WKR + LR SG+YY KG +K R L
Sbjct: 299 LEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQ 358
Query: 278 VNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFK 337
N+Y TQ + Y PTD+ F +K +++ + ++ C +D ++ W+ R+ K
Sbjct: 359 FENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAK 418
Query: 338 YGVQLYKNYQQAQSR 352
YG LY NYQ+A ++
Sbjct: 419 YGKTLYDNYQRAVAK 433
Score = 29.6 bits (65), Expect = 7.2
Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 10/94 (10%)
Query: 10 LSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPN 69
L + P+D P P PP P P P + P +P + LP P
Sbjct: 546 LPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSY--AGIAGSELPPPPP 603
Query: 70 PFPELCSPPSQSPILGGPSSARGLLPRDASRPHV 103
P P P+ +P+ P SAR P A RP V
Sbjct: 604 PPP----APAPAPV---PDSARP-PPAVAKRPPV 629
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 6/107 (5%)
Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
++ H WFHG+ISREES++++ +G FL+R ++ N + L L H KV HY
Sbjct: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHY 216
Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 526
I ++ G+L S+ +G+ +F L QLVE + G+L L C
Sbjct: 217 RI-DKDKTGKL--SIPEGK-KFDTLWQLVEHYSYKADGLLRVLTVPC 259
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
+F G I+REE++ + Q G+ DGL+L+R+S+ GF LS+ H +K HY I E E
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLR 524
+++ G+T + L +H L CLL+
Sbjct: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 54.7 bits (130), Expect = 2e-07
Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 6/107 (5%)
Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
++ H WFHG+ISREES++++ +G FL+R ++ N + L L H KV HY
Sbjct: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHY 216
Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 526
I ++ G+L S+ +G+ +F L QLVE + G+L L C
Sbjct: 217 RI-DKDKTGKL--SIPEGK-KFDTLWQLVEHYSYKADGLLRVLTVPC 259
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
+F G I+REE++ + Q G+ DGL+L+R+S+ GF LS+ H +K HY I E E
Sbjct: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLR 524
+++ G+T + L +H L CLL+
Sbjct: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 4/99 (4%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
+F+G ISR E++ + G+ DGLFL+R+ R+ G+VLSL H + H+ P E +
Sbjct: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529
+++ G+ +L EF+ + LPC LR C R
Sbjct: 67 GTYAIAGGKAH-CGPAELCEFYSRDPDGLPCNLRKPCNR 104
Score = 53.9 bits (128), Expect = 4e-07
Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 8/108 (7%)
Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQG-FVLSLCHLQKVKH 479
++ H W+H ++REE++R + DG FL+R R QG + LSL + + V H
Sbjct: 153 IATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRP--RKEQGTYALSLIYGKTVYH 210
Query: 480 YLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 526
YLI S+++ Y + +G T+F L QLVE+ +L G++ CL C
Sbjct: 211 YLI--SQDKAGKY-CIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WFHG+IS +E+ + + Q DGLFLVRES R+P +VL + + V HY +L +G
Sbjct: 81 WFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 136
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
L D F +L+ +VE + ++G +
Sbjct: 137 LTI---DEAVFFCNLMDMVEHYSKDKGAI 162
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WFHG+IS +E+ + + Q DGLFLVRES R+P +VL + + V HY +L +G
Sbjct: 123 WFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 178
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
L D F +L+ +VE + ++G +
Sbjct: 179 LTI---DEAVFFCNLMDMVEHYSKDKGAI 204
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 52.8 bits (125), Expect = 8e-07
Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WFHG+IS +E+ + + Q DGLFLVRES R+P +VL + + V HY +L +G
Sbjct: 122 WFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 177
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
L D F +L+ +VE + ++G +
Sbjct: 178 LTI---DEAVFFCNLMDMVEHYSKDKGAI 203
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ L++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 158 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 214
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
+Y + ++RF+ L +LV H
Sbjct: 215 VYVT---AESRFSTLAELVHHH 233
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ L++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 173 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 229
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
+Y + ++RF+ L +LV H
Sbjct: 230 VYVT---AESRFSTLAELVHHH 248
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ L++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 152 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 208
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
+Y + ++RF+ L +LV H
Sbjct: 209 VYVT---AESRFSTLAELVHHH 227
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ L++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 158 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 214
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
+Y + ++RF+ L +LV H
Sbjct: 215 VYVT---AESRFSTLAELVHHH 233
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ L++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 137 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 193
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
+Y + ++RF+ L +LV H
Sbjct: 194 VYVT---AESRFSTLAELVHHH 212
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/82 (39%), Positives = 49/82 (59%), Gaps = 7/82 (8%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WFHG+I+RE+++RL+ GLFLVRES P + L + KV+HY I+ +
Sbjct: 82 WFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASK-- 137
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
S+D+ + F +L+QLVE +
Sbjct: 138 --LSIDE-EVYFENLMQLVEHY 156
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 51.2 bits (121), Expect = 2e-06
Identities = 32/82 (39%), Positives = 49/82 (59%), Gaps = 7/82 (8%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WFHG+I+RE+++RL+ GLFLVRES P + L + KV+HY I+ +
Sbjct: 82 WFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASK-- 137
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
S+D+ + F +L+QLVE +
Sbjct: 138 --LSIDE-EVYFENLMQLVEHY 156
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 50.8 bits (120), Expect = 3e-06
Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 21/146 (14%)
Query: 380 HAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISRE 439
+ G E + +E ++K + L P L+ A ++ WFHG +S +
Sbjct: 66 YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP-----LNCADPTSERWFHGHLSGK 120
Query: 440 ESQRLIGQQGLVDGLFLVRESQRNPQGFVLSL----------CHLQKVKHYLILPSEEEG 489
E+++L+ ++G G FLVRESQ +P FVLS+ KV H +I E
Sbjct: 121 EAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQE--- 176
Query: 490 RLYFSMDDGQTRFTDLLQLVEFHQLN 515
L + + G+ RF L LVE ++ N
Sbjct: 177 -LKYDVGGGE-RFDSLTDLVEHYKKN 200
Score = 46.2 bits (108), Expect = 7e-05
Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WFH I+ E++ L+ +G VDG FL R S+ NP F LS+ V H I + +
Sbjct: 6 WFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
LY G +F L +LV+++ + G L
Sbjct: 65 LY-----GGEKFATLAELVQYYMEHHGQL 88
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 50.4 bits (119), Expect = 4e-06
Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ ++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 127 WYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI-NTASDGK 183
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
LY S ++RF L +LV H
Sbjct: 184 LYVS---SESRFNTLAELVHHH 202
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 50.4 bits (119), Expect = 4e-06
Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 6/82 (7%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
W+HG +SR ++ L+ ++G FLVRES+ +P +SL + +V HY I + +G+
Sbjct: 146 WYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI-NTASDGK 202
Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
LY S ++RF L +LV H
Sbjct: 203 LYVS---SESRFNTLAELVHHH 221
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 48.5 bits (114), Expect = 1e-05
Identities = 30/83 (36%), Positives = 44/83 (53%), Gaps = 4/83 (4%)
Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
WF G ISR E+ R + +G G FL+R S++ +VLS+ Q V+HY I GR
Sbjct: 78 WFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIW-RRAGGR 136
Query: 491 LYFSMDDGQTRFTDLLQLVEFHQ 513
L+ + F L +LV +H+
Sbjct: 137 LHL---NEAVSFLSLPELVNYHR 156
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 48.5 bits (114), Expect = 1e-05
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)
Query: 410 LSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
L +P P S++ + R + WFHG++SR E++ L+ ++G FLVRES P +VL
Sbjct: 358 LRVPPPPQSVSMAEQL-RGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVL 412
Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515
+ + KH L++ E R RF + L+ +H N
Sbjct: 413 TGLQSGQPKHLLLVDPEGVVR------TKDHRFESVSHLISYHMDN 452
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 48.5 bits (114), Expect = 1e-05
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)
Query: 410 LSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
L +P P S++ + R + WFHG++SR E++ L+ ++G FLVRES P +VL
Sbjct: 469 LRVPPPPQSVSMAEQL-RGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVL 523
Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515
+ + KH L++ E R RF + L+ +H N
Sbjct: 524 TGLQSGQPKHLLLVDPEGVVR------TKDHRFESVSHLISYHMDN 563
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 48.5 bits (114), Expect = 1e-05
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)
Query: 410 LSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
L +P P S++ + R + WFHG++SR E++ L+ ++G FLVRES P +VL
Sbjct: 468 LRVPPPPQSVSMAEQL-RGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVL 522
Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515
+ + KH L++ E R RF + L+ +H N
Sbjct: 523 TGLQSGQPKHLLLVDPEGVVR------TKDHRFESVSHLISYHMDN 562
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,973,154
Number of Sequences: 37866
Number of extensions: 1268928
Number of successful extensions: 9363
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 359
Number of HSP's that attempted gapping in prelim test: 7867
Number of HSP's gapped (non-prelim): 1472
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.