Guide to the Human Genome
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Search of human proteins with 71979665

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71979665 growth factor receptor-bound protein 7 [Homo
sapiens]
         (532 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]    1096   0.0  
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]    1096   0.0  
gi|48762697 growth factor receptor-bound protein 10 isoform c [H...   550   e-157
gi|48762695 growth factor receptor-bound protein 10 isoform c [H...   550   e-157
gi|48762679 growth factor receptor-bound protein 10 isoform a [H...   550   e-157
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]    495   e-140
gi|48762693 growth factor receptor-bound protein 10 isoform b [H...   468   e-132
gi|47132519 Ras association and pleckstrin homology domains 1 is...   143   4e-34
gi|42740893 Ras association and pleckstrin homology domains 1 is...   143   4e-34
gi|56118221 amyloid beta (A4) precursor protein-binding, family ...   142   1e-33
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           55   2e-07
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            55   2e-07
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1...    55   2e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...    53   8e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...    53   8e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...    53   8e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              52   2e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                52   2e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              52   2e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              52   2e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              52   2e-06
gi|187475373 c-src tyrosine kinase [Homo sapiens]                      51   2e-06
gi|4758078 c-src tyrosine kinase [Homo sapiens]                        51   2e-06
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [...    51   3e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    50   4e-06
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    50   4e-06
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]               49   1e-05
gi|194239668 SHC (Src homology 2 domain containing) transforming...    49   1e-05
gi|194239664 SHC (Src homology 2 domain containing) transforming...    49   1e-05
gi|194239662 SHC (Src homology 2 domain containing) transforming...    49   1e-05

>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 532/532 (100%), Positives = 532/532 (100%)

Query: 1   MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60
           MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR
Sbjct: 1   MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60

Query: 61  ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120
           ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA
Sbjct: 61  ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120

Query: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180
           GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
Sbjct: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180

Query: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240
           FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG
Sbjct: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240

Query: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300
           SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
Sbjct: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300

Query: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360
           FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG
Sbjct: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360

Query: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420
           SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS
Sbjct: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420

Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
           LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY
Sbjct: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480

Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
           LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Sbjct: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532


>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 532/532 (100%), Positives = 532/532 (100%)

Query: 1   MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60
           MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR
Sbjct: 1   MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERR 60

Query: 61  ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120
           ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA
Sbjct: 61  ATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAA 120

Query: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180
           GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV
Sbjct: 121 GATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFV 180

Query: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240
           FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG
Sbjct: 181 FRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRG 240

Query: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300
           SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG
Sbjct: 241 SGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFG 300

Query: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360
           FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG
Sbjct: 301 FCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLG 360

Query: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420
           SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS
Sbjct: 361 SPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTS 420

Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
           LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY
Sbjct: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480

Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
           LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL
Sbjct: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532


>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score =  550 bits (1418), Expect = e-157
 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)

Query: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
           P    PP + +P  +P  + V+RSQP+ I    R+L+EE++  R +SLP+IPNPFPELC 
Sbjct: 32  PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 89

Query: 77  PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
           P S   +  G      L P  A+    VKV+SEDG  + VE+ A  TAR +C++LV ++H
Sbjct: 90  PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 144

Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
            + D +W LVE HPHL LER LEDHE VV+V++   +  +S+F+FRKN+AKYE FK+ P 
Sbjct: 145 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 201

Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
           + FPE+MV+ C  ++   S   L+QNFLN+ S PEIQGFL ++  G+K WK+ +  LRRS
Sbjct: 202 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 259

Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
           GLY STKGTSK+PRHLQ +AD+ +SN++ +  GRK Y  PTD G C+KPNK+RN  K LR
Sbjct: 260 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 319

Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
           + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+  Q R    S   S P+RS S+N+LVAMD
Sbjct: 320 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 378

Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
           FSG  GRVIENP EA S ALEE  AWRK++     L    P   ++LS  IHRTQ WFHG
Sbjct: 379 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 438

Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
           RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 439 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 498

Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
           +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 499 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536


>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score =  550 bits (1418), Expect = e-157
 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)

Query: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
           P    PP + +P  +P  + V+RSQP+ I    R+L+EE++  R +SLP+IPNPFPELC 
Sbjct: 32  PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 89

Query: 77  PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
           P S   +  G      L P  A+    VKV+SEDG  + VE+ A  TAR +C++LV ++H
Sbjct: 90  PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 144

Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
            + D +W LVE HPHL LER LEDHE VV+V++   +  +S+F+FRKN+AKYE FK+ P 
Sbjct: 145 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 201

Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
           + FPE+MV+ C  ++   S   L+QNFLN+ S PEIQGFL ++  G+K WK+ +  LRRS
Sbjct: 202 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 259

Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
           GLY STKGTSK+PRHLQ +AD+ +SN++ +  GRK Y  PTD G C+KPNK+RN  K LR
Sbjct: 260 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 319

Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
           + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+  Q R    S   S P+RS S+N+LVAMD
Sbjct: 320 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 378

Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
           FSG  GRVIENP EA S ALEE  AWRK++     L    P   ++LS  IHRTQ WFHG
Sbjct: 379 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 438

Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
           RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 439 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 498

Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
           +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 499 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 536


>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
           sapiens]
          Length = 594

 Score =  550 bits (1418), Expect = e-157
 Identities = 283/518 (54%), Positives = 372/518 (71%), Gaps = 17/518 (3%)

Query: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
           P    PP + +P  +P  + V+RSQP+ I    R+L+EE++  R +SLP+IPNPFPELC 
Sbjct: 90  PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147

Query: 77  PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
           P S   +  G      L P  A+    VKV+SEDG  + VE+ A  TAR +C++LV ++H
Sbjct: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202

Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
            + D +W LVE HPHL LER LEDHE VV+V++   +  +S+F+FRKN+AKYE FK+ P 
Sbjct: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259

Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
           + FPE+MV+ C  ++   S   L+QNFLN+ S PEIQGFL ++  G+K WK+ +  LRRS
Sbjct: 260 NFFPEQMVTWCQQSNG--SQTQLLQNFLNSSSCPEIQGFLHVKELGKKSWKKLYVCLRRS 317

Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
           GLY STKGTSK+PRHLQ +AD+ +SN++ +  GRK Y  PTD G C+KPNK+RN  K LR
Sbjct: 318 GLYCSTKGTSKEPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 377

Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
           + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+  Q R    S   S P+RS S+N+LVAMD
Sbjct: 378 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 436

Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
           FSG  GRVIENP EA S ALEE  AWRK++     L    P   ++LS  IHRTQ WFHG
Sbjct: 437 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 496

Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
           RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 497 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 556

Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
           +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 557 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 594


>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
          Length = 540

 Score =  495 bits (1275), Expect = e-140
 Identities = 246/483 (50%), Positives = 337/483 (69%), Gaps = 13/483 (2%)

Query: 55  REEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRP-HVVKVYSEDGAC 113
           ++++     +PSIPNPFPELC  P  S +      +  L P+  SR   V+KVYSED   
Sbjct: 66  KKKDLDVPEMPSIPNPFPELCCSPFTSVL------SADLFPKANSRKKQVIKVYSEDETS 119

Query: 114 RSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPV 173
           R+++V +  TAR VC++L+ + H + D +W L E  PH+ +ER +EDHE V+EV + W +
Sbjct: 120 RALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGI 179

Query: 174 GGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQ 233
             +++  FRKN+AKYE FK+ P   FPE MVS   + +  IS   ++Q FL++ ++PEI 
Sbjct: 180 EEENKLYFRKNYAKYEFFKN-PMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIH 238

Query: 234 GFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLY 293
           GFL  +  G+K WK+ + FLRRSGLY+STKGTSK+PRHLQ+ ++   S++YV   G+K +
Sbjct: 239 GFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKH 298

Query: 294 GMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRH 353
           G PT++GFC KPNK   G + L++ C+E+EQSRTCW+ A RL KYG+QLY+NY       
Sbjct: 299 GAPTNYGFCFKPNKA-GGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGR 357

Query: 354 LHPSCLGSPPLRSASDNTLVAMDFSGHAGRVIENPREALSVALEEAQAWRKKTNHRLSLP 413
              S     P+RS S+N+LVAMDFSG   RVIENP EALSVA+EE  AWRKK   RL   
Sbjct: 358 SGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTH 417

Query: 414 MPASGTSLSAA----IHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
              + +S S+A    IHR+Q WFH +ISR+E+QRLI QQGLVDG+FLVR+SQ NP+ FVL
Sbjct: 418 GSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVL 477

Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529
           S+ H QK+KH+ I+P E++G ++ ++DDG TRFTDL+QLVEF+QLN+G+LPC L+H C R
Sbjct: 478 SMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 537

Query: 530 VAL 532
           +AL
Sbjct: 538 IAL 540


>gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo
           sapiens]
          Length = 548

 Score =  468 bits (1204), Expect = e-132
 Identities = 253/518 (48%), Positives = 336/518 (64%), Gaps = 63/518 (12%)

Query: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEER--RATSLPSIPNPFPELCS 76
           P    PP + +P  +P  + V+RSQP+ I    R+L+EE++  R +SLP+IPNPFPELC 
Sbjct: 90  PRASGPPRSIQPQVSPR-QRVQRSQPVHILAV-RRLQEEDQQFRTSSLPAIPNPFPELCG 147

Query: 77  PPSQSPILGGPSSARGLLPRDASRPHVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAH 136
           P S   +  G      L P  A+    VKV+SEDG  + VE+ A  TAR +C++LV ++H
Sbjct: 148 PGSPPVLTPG-----SLPPSQAAAKQDVKVFSEDGTSKVVEILADMTARDLCQLLVYKSH 202

Query: 137 ALSDETWGLVECHPHLALERGLEDHESVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPH 196
            + D +W LVE HPHL LER LEDHE VV+V++   +  +S+F+FRKN+AKYE FK+ P 
Sbjct: 203 CVDDNSWTLVEHHPHLGLERCLEDHELVVQVEST--MASESKFLFRKNYAKYEFFKN-PM 259

Query: 197 SLFPEKMVSSCLDAHTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRS 256
           + FPE+MV+ C  ++   S   L+Q                                   
Sbjct: 260 NFFPEQMVTWCQQSNG--SQTQLLQ----------------------------------- 282

Query: 257 GLYYSTKGTSKDPRHLQYVADVNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLR 316
                      +PRHLQ +AD+ +SN++ +  GRK Y  PTD G C+KPNK+RN  K LR
Sbjct: 283 -----------EPRHLQLLADLEDSNIFSLIAGRKQYNAPTDHGLCIKPNKVRNETKELR 331

Query: 317 IFCSEDEQSRTCWLAAFRLFKYGVQLYKNYQQAQSRHLHPSCLGSPPLRSASDNTLVAMD 376
           + C+EDEQ+RTCW+ AFRL KYG+ LY+NY+  Q R    S   S P+RS S+N+LVAMD
Sbjct: 332 LLCAEDEQTRTCWMTAFRLLKYGMLLYQNYRIPQQRKALLSPF-STPVRSVSENSLVAMD 390

Query: 377 FSGHAGRVIENPREALSVALEEAQAWRKKTNHR--LSLPMPASGTSLSAAIHRTQLWFHG 434
           FSG  GRVIENP EA S ALEE  AWRK++     L    P   ++LS  IHRTQ WFHG
Sbjct: 391 FSGQTGRVIENPAEAQSAALEEGHAWRKRSTRMNILGSQSPLHPSTLSTVIHRTQHWFHG 450

Query: 435 RISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGRLYFS 494
           RISREES R+I QQGLVDGLFL+R+SQ NP+ FVL+LCH QK+K++ ILP E++G+ +FS
Sbjct: 451 RISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQTFFS 510

Query: 495 MDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTRVAL 532
           +DDG T+F+DL+QLV+F+QLN+G+LPC L+H C RVAL
Sbjct: 511 LDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL 548


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score =  143 bits (360), Expect = 4e-34
 Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)

Query: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162
           V++V+  D + +++ V    T R V + L+ ++H      W LVE    L +ER  EDHE
Sbjct: 272 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 331

Query: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222
           ++VE    W     ++ +F +   KY LFK+  + L  +K  +   D +  +  E+    
Sbjct: 332 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 391

Query: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282
             ++ + PEI+G L L+  G+K WK+ +  LR SG+YY  KG +K  R L     ++  N
Sbjct: 392 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 449

Query: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342
           VY     R  Y  PTD+   +K  +++   + ++  C +D ++   W+   R+ KYG QL
Sbjct: 450 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 509

Query: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383
           Y NYQ+A  R       + L S  ++S S ++ +    S H+ +
Sbjct: 510 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 553



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 21/69 (30%), Positives = 28/69 (40%), Gaps = 9/69 (13%)

Query: 19  PAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPP 78
           P P TPP     P  P+P  V    P   P    K + +        SIP P P+   PP
Sbjct: 870 PPPPTPPAMESQPLKPVPANVAPQSP---PAVKAKPKWQP------SSIPVPSPDFPPPP 920

Query: 79  SQSPILGGP 87
            +S ++  P
Sbjct: 921 PESSLVFPP 929



 Score = 29.3 bits (64), Expect = 9.4
 Identities = 12/29 (41%), Positives = 14/29 (48%)

Query: 8   PHLSSSPEDLCPAPGTPPGTPRPPDTPLP 36
           P+ +S P    P P  PP  P PP  P P
Sbjct: 618 PYTASQPSPPLPPPPPPPPPPPPPPPPPP 646



 Score = 29.3 bits (64), Expect = 9.4
 Identities = 27/109 (24%), Positives = 43/109 (39%), Gaps = 19/109 (17%)

Query: 6   SPPHLSSS---PEDLCPAPGTPPGTPRPPDTPLP-EEVKRSQP---------LLIPTTGR 52
           +PP + S    P+ L P  G  P  P PP  P P   + + +P            P    
Sbjct: 688 TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747

Query: 53  KLREEERRATSLPSIPNPFPELCSP-PSQSP-----ILGGPSSARGLLP 95
           K+ + +      P  P P P + +P P Q+P      +  P+S + + P
Sbjct: 748 KIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAP 796


>gi|42740893 Ras association and pleckstrin homology domains 1
           isoform 3 [Homo sapiens]
          Length = 644

 Score =  143 bits (360), Expect = 4e-34
 Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)

Query: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162
           V++V+  D + +++ V    T R V + L+ ++H      W LVE    L +ER  EDHE
Sbjct: 324 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 383

Query: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222
           ++VE    W     ++ +F +   KY LFK+  + L  +K  +   D +  +  E+    
Sbjct: 384 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 443

Query: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282
             ++ + PEI+G L L+  G+K WK+ +  LR SG+YY  KG +K  R L     ++  N
Sbjct: 444 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 501

Query: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342
           VY     R  Y  PTD+   +K  +++   + ++  C +D ++   W+   R+ KYG QL
Sbjct: 502 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 561

Query: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383
           Y NYQ+A  R       + L S  ++S S ++ +    S H+ +
Sbjct: 562 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 605


>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
           member 1 interacting protein [Homo sapiens]
          Length = 666

 Score =  142 bits (357), Expect = 1e-33
 Identities = 80/255 (31%), Positives = 132/255 (51%), Gaps = 5/255 (1%)

Query: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162
           VVKV+  D + +S+ V     AR V + L ++ H   +  W L E +P L +ER  EDHE
Sbjct: 179 VVKVHMNDNSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHE 238

Query: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGIS---HEDL 219
           +VVEV + W    +++ +F +   KY +FK+  +     +      + +  ++    E L
Sbjct: 239 NVVEVLSDWTRDTENKILFLEKEEKYAVFKNPQNFYLDNRGKKESKETNEKMNAKNKESL 298

Query: 220 IQNFLNAGSF--PEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVAD 277
           ++      S   PE++G L L+  G+K WKR +  LR SG+YY  KG +K  R L     
Sbjct: 299 LEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQ 358

Query: 278 VNESNVYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFK 337
               N+Y  TQ +  Y  PTD+ F +K  +++   + ++  C +D ++   W+   R+ K
Sbjct: 359 FENVNIYYGTQHKMKYKAPTDYCFVLKHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAK 418

Query: 338 YGVQLYKNYQQAQSR 352
           YG  LY NYQ+A ++
Sbjct: 419 YGKTLYDNYQRAVAK 433



 Score = 29.6 bits (65), Expect = 7.2
 Identities = 28/94 (29%), Positives = 36/94 (38%), Gaps = 10/94 (10%)

Query: 10  LSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPN 69
           L + P+D  P P  PP    P   P P +     P  +P             + LP  P 
Sbjct: 546 LPAPPDDFLPPPPPPPPLDDPELPPPPPDFMEPPPDFVPPPPPSY--AGIAGSELPPPPP 603

Query: 70  PFPELCSPPSQSPILGGPSSARGLLPRDASRPHV 103
           P P     P+ +P+   P SAR   P  A RP V
Sbjct: 604 PPP----APAPAPV---PDSARP-PPAVAKRPPV 629


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 6/107 (5%)

Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
           ++   H    WFHG+ISREES++++      +G FL+R ++ N   + L L H  KV HY
Sbjct: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHY 216

Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 526
            I   ++ G+L  S+ +G+ +F  L QLVE +     G+L  L   C
Sbjct: 217 RI-DKDKTGKL--SIPEGK-KFDTLWQLVEHYSYKADGLLRVLTVPC 259



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           +F G I+REE++  + Q G+ DGL+L+R+S+    GF LS+ H +K  HY I   E E  
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLR 524
             +++  G+T  +    L  +H      L CLL+
Sbjct: 72  GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 6/107 (5%)

Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 480
           ++   H    WFHG+ISREES++++      +G FL+R ++ N   + L L H  KV HY
Sbjct: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHY 216

Query: 481 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 526
            I   ++ G+L  S+ +G+ +F  L QLVE +     G+L  L   C
Sbjct: 217 RI-DKDKTGKL--SIPEGK-KFDTLWQLVEHYSYKADGLLRVLTVPC 259



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           +F G I+REE++  + Q G+ DGL+L+R+S+    GF LS+ H +K  HY I   E E  
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLR 524
             +++  G+T  +    L  +H      L CLL+
Sbjct: 72  GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104


>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
           [Homo sapiens]
          Length = 619

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 4/99 (4%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           +F+G ISR E++  +   G+ DGLFL+R+  R+  G+VLSL H  +  H+   P E +  
Sbjct: 10  FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 529
             +++  G+       +L EF+  +   LPC LR  C R
Sbjct: 67  GTYAIAGGKAH-CGPAELCEFYSRDPDGLPCNLRKPCNR 104



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 38/108 (35%), Positives = 60/108 (55%), Gaps = 8/108 (7%)

Query: 421 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQG-FVLSLCHLQKVKH 479
           ++   H    W+H  ++REE++R +      DG FL+R   R  QG + LSL + + V H
Sbjct: 153 IATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRP--RKEQGTYALSLIYGKTVYH 210

Query: 480 YLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 526
           YLI  S+++   Y  + +G T+F  L QLVE+ +L   G++ CL   C
Sbjct: 211 YLI--SQDKAGKY-CIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 7/89 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WFHG+IS +E+ + +  Q   DGLFLVRES R+P  +VL +   + V HY +L    +G 
Sbjct: 81  WFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 136

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
           L     D    F +L+ +VE +  ++G +
Sbjct: 137 LTI---DEAVFFCNLMDMVEHYSKDKGAI 162


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 7/89 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WFHG+IS +E+ + +  Q   DGLFLVRES R+P  +VL +   + V HY +L    +G 
Sbjct: 123 WFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 178

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
           L     D    F +L+ +VE +  ++G +
Sbjct: 179 LTI---DEAVFFCNLMDMVEHYSKDKGAI 204


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 33/89 (37%), Positives = 51/89 (57%), Gaps = 7/89 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WFHG+IS +E+ + +  Q   DGLFLVRES R+P  +VL +   + V HY +L    +G 
Sbjct: 122 WFHGKISGQEAVQQL--QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVL--HRDGH 177

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
           L     D    F +L+ +VE +  ++G +
Sbjct: 178 LTI---DEAVFFCNLMDMVEHYSKDKGAI 203


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+    L++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 158 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 214

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           +Y +    ++RF+ L +LV  H
Sbjct: 215 VYVT---AESRFSTLAELVHHH 233


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+    L++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 173 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 229

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           +Y +    ++RF+ L +LV  H
Sbjct: 230 VYVT---AESRFSTLAELVHHH 248


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+    L++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 152 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 208

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           +Y +    ++RF+ L +LV  H
Sbjct: 209 VYVT---AESRFSTLAELVHHH 227


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+    L++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 158 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 214

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           +Y +    ++RF+ L +LV  H
Sbjct: 215 VYVT---AESRFSTLAELVHHH 233


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 29/82 (35%), Positives = 50/82 (60%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+    L++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 137 WYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRI-NTTADGK 193

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           +Y +    ++RF+ L +LV  H
Sbjct: 194 VYVT---AESRFSTLAELVHHH 212


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 32/82 (39%), Positives = 49/82 (59%), Gaps = 7/82 (8%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WFHG+I+RE+++RL+       GLFLVRES   P  + L +    KV+HY I+    +  
Sbjct: 82  WFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASK-- 137

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
              S+D+ +  F +L+QLVE +
Sbjct: 138 --LSIDE-EVYFENLMQLVEHY 156


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 32/82 (39%), Positives = 49/82 (59%), Gaps = 7/82 (8%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WFHG+I+RE+++RL+       GLFLVRES   P  + L +    KV+HY I+    +  
Sbjct: 82  WFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASK-- 137

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
              S+D+ +  F +L+QLVE +
Sbjct: 138 --LSIDE-EVYFENLMQLVEHY 156


>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
           [Homo sapiens]
          Length = 593

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 43/146 (29%), Positives = 68/146 (46%), Gaps = 21/146 (14%)

Query: 380 HAGRVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRTQLWFHGRISRE 439
           + G       E +   +E     ++K    + L  P     L+ A   ++ WFHG +S +
Sbjct: 66  YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP-----LNCADPTSERWFHGHLSGK 120

Query: 440 ESQRLIGQQGLVDGLFLVRESQRNPQGFVLSL----------CHLQKVKHYLILPSEEEG 489
           E+++L+ ++G   G FLVRESQ +P  FVLS+              KV H +I   E   
Sbjct: 121 EAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQE--- 176

Query: 490 RLYFSMDDGQTRFTDLLQLVEFHQLN 515
            L + +  G+ RF  L  LVE ++ N
Sbjct: 177 -LKYDVGGGE-RFDSLTDLVEHYKKN 200



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 6/89 (6%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WFH  I+  E++ L+  +G VDG FL R S+ NP  F LS+     V H  I  + +   
Sbjct: 6   WFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQLNRGIL 519
           LY     G  +F  L +LV+++  + G L
Sbjct: 65  LY-----GGEKFATLAELVQYYMEHHGQL 88


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+     ++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 127 WYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI-NTASDGK 183

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           LY S    ++RF  L +LV  H
Sbjct: 184 LYVS---SESRFNTLAELVHHH 202


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 30/82 (36%), Positives = 48/82 (58%), Gaps = 6/82 (7%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           W+HG +SR  ++ L+     ++G FLVRES+ +P    +SL +  +V HY I  +  +G+
Sbjct: 146 WYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI-NTASDGK 202

Query: 491 LYFSMDDGQTRFTDLLQLVEFH 512
           LY S    ++RF  L +LV  H
Sbjct: 203 LYVS---SESRFNTLAELVHHH 221


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 30/83 (36%), Positives = 44/83 (53%), Gaps = 4/83 (4%)

Query: 431 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 490
           WF G ISR E+ R +  +G   G FL+R S++    +VLS+   Q V+HY I      GR
Sbjct: 78  WFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIW-RRAGGR 136

Query: 491 LYFSMDDGQTRFTDLLQLVEFHQ 513
           L+    +    F  L +LV +H+
Sbjct: 137 LHL---NEAVSFLSLPELVNYHR 156


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)

Query: 410 LSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
           L +P P    S++  + R + WFHG++SR E++ L+     ++G FLVRES   P  +VL
Sbjct: 358 LRVPPPPQSVSMAEQL-RGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVL 412

Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515
           +     + KH L++  E   R          RF  +  L+ +H  N
Sbjct: 413 TGLQSGQPKHLLLVDPEGVVR------TKDHRFESVSHLISYHMDN 452


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)

Query: 410 LSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
           L +P P    S++  + R + WFHG++SR E++ L+     ++G FLVRES   P  +VL
Sbjct: 469 LRVPPPPQSVSMAEQL-RGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVL 523

Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515
           +     + KH L++  E   R          RF  +  L+ +H  N
Sbjct: 524 TGLQSGQPKHLLLVDPEGVVR------TKDHRFESVSHLISYHMDN 563


>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)

Query: 410 LSLPMPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVL 469
           L +P P    S++  + R + WFHG++SR E++ L+     ++G FLVRES   P  +VL
Sbjct: 468 LRVPPPPQSVSMAEQL-RGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVL 522

Query: 470 SLCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLN 515
           +     + KH L++  E   R          RF  +  L+ +H  N
Sbjct: 523 TGLQSGQPKHLLLVDPEGVVR------TKDHRFESVSHLISYHMDN 562


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,973,154
Number of Sequences: 37866
Number of extensions: 1268928
Number of successful extensions: 9363
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 359
Number of HSP's that attempted gapping in prelim test: 7867
Number of HSP's gapped (non-prelim): 1472
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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