Guide to the Human Genome
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Search of human proteins with 7108336

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
         (532 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]         1086   0.0  
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]          528   e-150
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]         486   e-137
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]         400   e-111
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]          388   e-108
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]         388   e-108
gi|149158709 histamine receptor H1 [Homo sapiens]                     194   1e-49
gi|149158706 histamine receptor H1 [Homo sapiens]                     194   1e-49
gi|149158704 histamine receptor H1 [Homo sapiens]                     194   1e-49
gi|4504491 histamine receptor H1 [Homo sapiens]                       194   1e-49
gi|194018562 histamine receptor H3 [Homo sapiens]                     156   5e-38
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]               154   3e-37
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap...   131   2e-30
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      128   1e-29
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                128   1e-29
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa...   127   3e-29
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]                127   3e-29
gi|4557265 beta-1-adrenergic receptor [Homo sapiens]                  124   2e-28
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    124   2e-28
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    124   2e-28
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    124   2e-28
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    124   2e-28
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap...   124   3e-28
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]              122   6e-28

>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
          Length = 532

 Score = 1086 bits (2808), Expect = 0.0
 Identities = 532/532 (100%), Positives = 532/532 (100%)

Query: 1   MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 60
           MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
Sbjct: 1   MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 60

Query: 61  LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 120
           LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
Sbjct: 61  LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 120

Query: 121 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 180
           LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
Sbjct: 121 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 180

Query: 181 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE 240
           DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
Sbjct: 181 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE 240

Query: 241 KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL 300
           KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
Sbjct: 241 KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL 300

Query: 301 TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN 360
           TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
Sbjct: 301 TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN 360

Query: 361 YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP 420
           YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
Sbjct: 361 YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP 420

Query: 421 NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG 480
           NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
Sbjct: 421 NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG 480

Query: 481 YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 532
           YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
Sbjct: 481 YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 532


>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
          Length = 590

 Score =  528 bits (1359), Expect = e-150
 Identities = 288/545 (52%), Positives = 358/545 (65%), Gaps = 37/545 (6%)

Query: 8   NATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNY 67
           N ++ +GT     PL  H +W+V+ IA +T +++L+TI+GN+LV++SFKVN QLKTVNNY
Sbjct: 48  NFSSPDGT--TDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105

Query: 68  YLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFD 127
           +LLSLACADLIIG+ SMNL+TTYI+M RWALG+LACDLWLA+DYVASNASVMNLLVISFD
Sbjct: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165

Query: 128 RYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQF 187
           RYFSITRPLTYRAKRT KRAG+MIGLAW+ISF+LWAPAIL WQY VGKRTVP  EC IQF
Sbjct: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225

Query: 188 LSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAH- 246
           LSEPTITFGTAIAAFY+PV++MTILY RIY+ETEKRTK+LA LQ S   T+AE     H 
Sbjct: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASG--TEAETENFVHP 283

Query: 247 RALFRSCLRCPRPTLAQRERNQAS------WSSSRRSTSTTGKPSQATGPSANWAKAEQL 300
               RSC        + +  N+        W +++    ++ +  Q    S +W   +  
Sbjct: 284 TGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAA 343

Query: 301 TTCSSYPSSEDED-KPATDPVLQVVYKSQGKES---------------PGEEFSAEETEE 344
            +  +  SS++ED    T  +  +V K  G  +               P EE    + E 
Sbjct: 344 ASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLER 403

Query: 345 TFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMP 404
              K + +KS  D  ++         PKS   +  +    V      + N+   K     
Sbjct: 404 KADKLQAQKSVDDGGSF---------PKSFSKLPIQLESAVDTAKTSDVNSSVGK-STAT 453

Query: 405 CPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLV 464
            P    +    K        Q+TKRKR+ LVKE+KAAQTLSAILLAFIITWTPYNIMVLV
Sbjct: 454 LPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLV 513

Query: 465 STFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLY 524
           +TFCD C+P T W+LGYWLCY+NSTVNP+CYALCN+TFR TFKMLLLC+  KKK  ++ Y
Sbjct: 514 NTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQY 573

Query: 525 WQGNS 529
            Q  S
Sbjct: 574 QQRQS 578


>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
          Length = 460

 Score =  486 bits (1252), Expect = e-137
 Identities = 257/491 (52%), Positives = 317/491 (64%), Gaps = 72/491 (14%)

Query: 28  WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87
           W+V  I   T ++SL T+ GN+LV+ISFKVN++LKTVNNY+LLSLACADLIIG FSMNLY
Sbjct: 23  WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLY 82

Query: 88  TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147
           TTY+LMG WALG+LACDLWLALDYVASNASVMNLL+ISFDRYFS+TRPL+YRAKRTP+RA
Sbjct: 83  TTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRA 142

Query: 148 GIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVS 207
            +MIGLAWL+SF+LWAPAIL WQYLVG+RTV   +C IQFLS+P ITFGTA+AAFY+PV+
Sbjct: 143 ALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVT 202

Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267
           VM  LY RIYRETE R ++LA LQGS++  K                             
Sbjct: 203 VMCTLYWRIYRETENRARELAALQGSETPGKG---------------------------G 235

Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327
            +S SS R      G P    G      +A +L    S+   E+ED+ +    ++ +  S
Sbjct: 236 GSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGS----MESLTSS 291

Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387
           +G+E   E        +   +A T++    +PN +  P                      
Sbjct: 292 EGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRP---------------------- 329

Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAI 447
                T  G              ++ + KG  P    Q+ KRK   LVKE+KAA+TLSAI
Sbjct: 330 -----TKKG--------------RDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAI 370

Query: 448 LLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFK 507
           LLAFI+TWTPYNIMVLVSTFC  CVP TLW LGYWLCYVNST+NP+CYALCN+ FR TF+
Sbjct: 371 LLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFR 430

Query: 508 MLLLCRWKKKK 518
           +LLLCRW K++
Sbjct: 431 LLLLCRWDKRR 441


>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
          Length = 479

 Score =  400 bits (1027), Expect = e-111
 Identities = 243/534 (45%), Positives = 308/534 (57%), Gaps = 89/534 (16%)

Query: 8   NATTVNGTPVNHQPL-------ERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 60
           N T VNG+  N            R+   E++ IA VT  +SL+T+VGN+LVM+S KVN Q
Sbjct: 3   NFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ 62

Query: 61  LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 120
           L+TVNNY+L SLACADLIIG FSMNLYT YI+ G W LG++ CDLWLALDYV SNASVMN
Sbjct: 63  LQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMN 122

Query: 121 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 180
           LL+ISFDRYF +T+PLTY A+RT K AG+MI  AW++SF+LWAPAIL WQ++VGKRTVP 
Sbjct: 123 LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD 182

Query: 181 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILY--------CRIYRE-----TEKRTKDL 227
           ++C IQFLS P +TFGTAIAAFY+PV +MT+LY         R+++       EK+ K L
Sbjct: 183 NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL 242

Query: 228 ADLQG---SDSVTKAEKRKPAHRALFRSCL-RCPRPTLAQRERNQASWSSSRRSTSTTGK 283
           A L+      SV K    + A   L    L   P P L    R  A   +S  S+S +  
Sbjct: 243 AFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSAT 302

Query: 284 PSQATGPSANWAKAEQLTTCSSYPSSEDED-KPATD-PVLQVVYKSQGKESPGEEFSAEE 341
            +    P+   +  E  T     P  +     PA+    +Q+V K  G E          
Sbjct: 303 QNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNEC--------V 354

Query: 342 TEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVK 401
           T    V A        TP       A  RP +   VA KF  + +   NQ          
Sbjct: 355 TAIEIVPA--------TP-------AGMRPAAN--VARKFASIAR---NQ---------- 384

Query: 402 IMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIM 461
                  V K+            QM  R+R       K  +T+ AILLAFI+TWTPYN+M
Sbjct: 385 -------VRKK-----------RQMAARER-------KVTRTIFAILLAFILTWTPYNVM 419

Query: 462 VLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWK 515
           VLV+TFC  C+P T+W +GYWLCYVNST+NP CYALCN TF+KTF+ LLLC+++
Sbjct: 420 VLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR 473


>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
          Length = 466

 Score =  388 bits (997), Expect = e-108
 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%)

Query: 25  HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84
           ++ +EV+ I  V   +SL+TI+GN+LVM+S KVN  L+TVNNY+L SLACADLIIG+FSM
Sbjct: 18  YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77

Query: 85  NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144
           NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY  KRT 
Sbjct: 78  NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137

Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204
           K AG+MI  AW++SFILWAPAIL WQ++VG RTV   EC IQF S   +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197

Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264
           PV +MT+LY  I R ++ R K        D       + P   +L +  +  P       
Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243

Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324
                         +    PS   G   N                    K   DPV +  
Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274

Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373
            + + KES  +  S               +E  V      S  +             PKS
Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334

Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432
             C      + V     Q   NG  K  I+      + K+P+ K   P PS         
Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380

Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492
              +E+K  +T+ AILLAFIITW PYN+MVL++TFC  C+P T+W +GYWLCY+NST+NP
Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437

Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515
            CYALCN TF+KTFK LL+C +K
Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460


>gi|149158709 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  194 bits (494), Expect = 1e-49
 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%)

Query: 29  EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88
           +++ +  V + + L+T+  N+LV+ + +   +L TV N Y++SL+ ADLI+G   M +  
Sbjct: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85

Query: 89  TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148
            Y+LM +W+LG   C  WL++DYVAS AS+ ++ ++  DRY S+ +PL Y   RT  RA 
Sbjct: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145

Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207
             I  AW +SF LW   IL W + + + +V   D+C+  F         TAI  FY+P  
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204

Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267
           +M   Y +IY+   +  +    +  S       K +P +          P+   A++   
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253

Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327
           ++ W   +R     G  S    PS    K  +     S     + DK    P L +V+  
Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311

Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387
              E    ++ A       +K + +         L +  A+   + Q     +      +
Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363

Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440
           D   ET  G  K+          +  S  GL+          SH       + + +ERKA
Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413

Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500
           A+ L  I+ AFI+ W PY I  +V  FC  C    L     WL Y+NST+NP+ Y LCN 
Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473

Query: 501 TFRKTFKMLLLCR 513
            F+KTFK +L  R
Sbjct: 474 NFKKTFKRILHIR 486


>gi|149158706 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  194 bits (494), Expect = 1e-49
 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%)

Query: 29  EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88
           +++ +  V + + L+T+  N+LV+ + +   +L TV N Y++SL+ ADLI+G   M +  
Sbjct: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85

Query: 89  TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148
            Y+LM +W+LG   C  WL++DYVAS AS+ ++ ++  DRY S+ +PL Y   RT  RA 
Sbjct: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145

Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207
             I  AW +SF LW   IL W + + + +V   D+C+  F         TAI  FY+P  
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204

Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267
           +M   Y +IY+   +  +    +  S       K +P +          P+   A++   
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253

Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327
           ++ W   +R     G  S    PS    K  +     S     + DK    P L +V+  
Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311

Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387
              E    ++ A       +K + +         L +  A+   + Q     +      +
Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363

Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440
           D   ET  G  K+          +  S  GL+          SH       + + +ERKA
Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413

Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500
           A+ L  I+ AFI+ W PY I  +V  FC  C    L     WL Y+NST+NP+ Y LCN 
Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473

Query: 501 TFRKTFKMLLLCR 513
            F+KTFK +L  R
Sbjct: 474 NFKKTFKRILHIR 486


>gi|149158704 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  194 bits (494), Expect = 1e-49
 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%)

Query: 29  EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88
           +++ +  V + + L+T+  N+LV+ + +   +L TV N Y++SL+ ADLI+G   M +  
Sbjct: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85

Query: 89  TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148
            Y+LM +W+LG   C  WL++DYVAS AS+ ++ ++  DRY S+ +PL Y   RT  RA 
Sbjct: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145

Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207
             I  AW +SF LW   IL W + + + +V   D+C+  F         TAI  FY+P  
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204

Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267
           +M   Y +IY+   +  +    +  S       K +P +          P+   A++   
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253

Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327
           ++ W   +R     G  S    PS    K  +     S     + DK    P L +V+  
Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311

Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387
              E    ++ A       +K + +         L +  A+   + Q     +      +
Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363

Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440
           D   ET  G  K+          +  S  GL+          SH       + + +ERKA
Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413

Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500
           A+ L  I+ AFI+ W PY I  +V  FC  C    L     WL Y+NST+NP+ Y LCN 
Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473

Query: 501 TFRKTFKMLLLCR 513
            F+KTFK +L  R
Sbjct: 474 NFKKTFKRILHIR 486


>gi|4504491 histamine receptor H1 [Homo sapiens]
          Length = 487

 Score =  194 bits (494), Expect = 1e-49
 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%)

Query: 29  EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88
           +++ +  V + + L+T+  N+LV+ + +   +L TV N Y++SL+ ADLI+G   M +  
Sbjct: 26  QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85

Query: 89  TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148
            Y+LM +W+LG   C  WL++DYVAS AS+ ++ ++  DRY S+ +PL Y   RT  RA 
Sbjct: 86  LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145

Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207
             I  AW +SF LW   IL W + + + +V   D+C+  F         TAI  FY+P  
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204

Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267
           +M   Y +IY+   +  +    +  S       K +P +          P+   A++   
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253

Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327
           ++ W   +R     G  S    PS    K  +     S     + DK    P L +V+  
Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311

Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387
              E    ++ A       +K + +         L +  A+   + Q     +      +
Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363

Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440
           D   ET  G  K+          +  S  GL+          SH       + + +ERKA
Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413

Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500
           A+ L  I+ AFI+ W PY I  +V  FC  C    L     WL Y+NST+NP+ Y LCN 
Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473

Query: 501 TFRKTFKMLLLCR 513
            F+KTFK +L  R
Sbjct: 474 NFKKTFKRILHIR 486


>gi|194018562 histamine receptor H3 [Homo sapiens]
          Length = 445

 Score =  156 bits (394), Expect = 5e-38
 Identities = 73/199 (36%), Positives = 123/199 (61%), Gaps = 2/199 (1%)

Query: 28  WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87
           W  + +AA+ A++ + T++GN LVM++F  +S L+T NN++LL+LA +D ++G F + LY
Sbjct: 33  WTAV-LAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLY 91

Query: 88  TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKR-TPKR 146
             Y+L GRW  G   C LWL +DY+   +S  N+++IS+DR+ S+TR ++YRA++   +R
Sbjct: 92  VPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRR 151

Query: 147 AGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPV 206
           A   + L W+++F+L+ PAIL W+YL G  ++P   C  +F          +   F+ P 
Sbjct: 152 AVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPF 211

Query: 207 SVMTILYCRIYRETEKRTK 225
             +T     IY   ++RT+
Sbjct: 212 LSVTFFNLSIYLNIQRRTR 230



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 4/111 (3%)

Query: 408 PVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTF 467
           P A   S +      S   T+R R  L ++RK A++L+ I+  F + W PY +++++   
Sbjct: 326 PSASSASLEKRMKMVSQSFTQRFR--LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAA 383

Query: 468 CD-KCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKK 517
           C   CVP   +   +WL + NS VNP+ Y LC+ +FR+ F   LLC  K K
Sbjct: 384 CHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTK-LLCPQKLK 433


>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
          Length = 450

 Score =  154 bits (388), Expect = 3e-37
 Identities = 120/485 (24%), Positives = 212/485 (43%), Gaps = 57/485 (11%)

Query: 33  IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYIL 92
           IAA    + L TI GN LV+++   +  L+   N +L+SLA AD+++    +       L
Sbjct: 15  IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74

Query: 93  MGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIG 152
           +G W      C+++LALD +   +S+++L  IS DRY++++R L Y +KRTP+R   +I 
Sbjct: 75  LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134

Query: 153 LAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTIL 212
             WLI+ ++  P ++   Y   +   P    Q +   E      ++I +F+ P  +M ++
Sbjct: 135 TVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILV 191

Query: 213 YCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAH-RALFRSCLRCPRPTLAQRERNQASW 271
           Y RIY   ++  +     +G     ++++ +P H  AL  + L       + RE N  S 
Sbjct: 192 YLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSK 251

Query: 272 SSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKE 331
           S+  +    T + +       +WA         + P+S    K             +G  
Sbjct: 252 STGEKEEGETPEDTGTRALPPSWA---------ALPNSGQGQK-------------EGVC 289

Query: 332 SPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQ 391
               E  AEE EE     E E+ + +     +SPA+A  P  Q+      R++    G  
Sbjct: 290 GASPEDEAEEEEE----EEEEEEECEPQAVPVSPASACSPPLQQ--PQGSRVLATLRGQV 343

Query: 392 ETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAF 451
               G   +                            R+R  L +E++    L+ ++  F
Sbjct: 344 LLGRGVGAI-----------------------GGQWWRRRAQLTREKRFTFVLAVVIGVF 380

Query: 452 IITWTPYNIMVLVSTFCDK-C-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKML 509
           ++ W P+     +   C K C VP  L+   +W+ Y NS++NP+ Y + N+ FR+ F+ +
Sbjct: 381 VLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRI 440

Query: 510 LLCRW 514
           L   W
Sbjct: 441 LCRPW 445


>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
           sapiens]
          Length = 390

 Score =  131 bits (329), Expect = 2e-30
 Identities = 73/213 (34%), Positives = 111/213 (52%), Gaps = 5/213 (2%)

Query: 28  WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87
           W+V+ +  + A+++L T + N  V+ +     +L T  NY + SLA  DL++ I  M + 
Sbjct: 48  WKVLLVMLL-ALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIS 106

Query: 88  TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147
           T Y + GRW LG + CD WL+ D     AS+++L VI+ DRY++IT  + Y AKRTPKRA
Sbjct: 107 TMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRA 166

Query: 148 GIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVS 207
            +MI L W+ S  +  P     Q    K    + EC +        T  + + AFY P  
Sbjct: 167 AVMIALVWVFSISISLPPFFWRQ---AKAEEEVSECVVN-TDHILYTVYSTVGAFYFPTL 222

Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAE 240
           ++  LY RIY E   R       +    +T+A+
Sbjct: 223 LLIALYGRIYVEARSRILKQTPNRTGKRLTRAQ 255



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 34/90 (37%), Positives = 54/90 (60%), Gaps = 2/90 (2%)

Query: 423 SHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFC-DKC-VPVTLWHLG 480
           S  + ++K+++  +ERKA +TL  IL AFI+ W P+ I+ LV   C D C   + ++   
Sbjct: 295 SDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFF 354

Query: 481 YWLCYVNSTVNPICYALCNRTFRKTFKMLL 510
            WL Y+NS +NPI Y + N  F++ F  L+
Sbjct: 355 TWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  128 bits (322), Expect = 1e-29
 Identities = 65/233 (27%), Positives = 127/233 (54%), Gaps = 4/233 (1%)

Query: 3   GDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLK 62
           G ++  A   +  P +    +R  +W V+ +  V +++ L  + GNVLV+ +     +L+
Sbjct: 7   GSAFLLAPNRSHAPDHDVTQQRDEVW-VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQ 65

Query: 63  TVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLL 122
           TV NY++ SLACADL++G+  +     +ILM  W  G+  C+ W ++D +   AS+  L 
Sbjct: 66  TVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLC 125

Query: 123 VISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFIL-WAPAILCWQYLVGKRTVP-- 179
           VI+ DRYF+IT P  Y++  T  +A ++I + W++S +  + P  + W     +  +   
Sbjct: 126 VIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCY 185

Query: 180 LDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQG 232
            +E    F +       ++I +FY+P+ +M  +Y R+++E +++ + +   +G
Sbjct: 186 ANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEG 238



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 1/86 (1%)

Query: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVN 487
           +R     +KE KA +TL  I+  F + W P+ I+ +V    D  +   ++ L  W+ YVN
Sbjct: 259 RRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVN 318

Query: 488 STVNPICYALCNRTFRKTFKMLLLCR 513
           S  NP+ Y   +  FR  F+ LL  R
Sbjct: 319 SGFNPLIYCR-SPDFRIAFQELLCLR 343


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score =  128 bits (322), Expect = 1e-29
 Identities = 68/220 (30%), Positives = 117/220 (53%), Gaps = 6/220 (2%)

Query: 8   NATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNY 67
           N T  N T  N   L +  +   I++  V     L  IVGN+LV++S   N  L+T  NY
Sbjct: 24  NFTGPNQTSSN-STLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNY 82

Query: 68  YLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFD 127
           ++++LA ADL++    +       ++G W LG + CD+W A+D +   AS+++L  IS D
Sbjct: 83  FIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISID 142

Query: 128 RYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQF 187
           RY  +   L Y    T ++A + +   W++S ++    +L W     K   P D+ +   
Sbjct: 143 RYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGW-----KEPAPNDDKECGV 197

Query: 188 LSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDL 227
             EP     +++ +FYIP++V+ ++YCR+Y   ++ TK+L
Sbjct: 198 TEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNL 237



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 34/101 (33%), Positives = 54/101 (53%), Gaps = 2/101 (1%)

Query: 414 STKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMV-LVSTFCDKCV 472
           STK    NP   +   K     +E+KAA+TL  ++  FI+ W P+ I + L S F     
Sbjct: 267 STKAKGHNPRSSIAV-KLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP 325

Query: 473 PVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCR 513
           P  ++ + +WL Y NS +NPI Y   ++ F++ F  +L C+
Sbjct: 326 PDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQ 366


>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
           sapiens]
          Length = 422

 Score =  127 bits (319), Expect = 3e-29
 Identities = 68/198 (34%), Positives = 114/198 (57%), Gaps = 5/198 (2%)

Query: 28  WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87
           ++VIT   +  ++    ++GN  V+ +  +   L+ V NY + SLA  DL++ +  + + 
Sbjct: 35  YQVITSLLLGTLI-FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMA 93

Query: 88  TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147
             Y ++ +W LG + CDL++ALD +   +S+++L  I+ DRY++IT P+ Y  KRTP+RA
Sbjct: 94  ALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRA 153

Query: 148 GIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVS 207
             +I L WLI F++  P +L W+     R+ P D C I    +   T  +   AFYIP+ 
Sbjct: 154 AALISLTWLIGFLISIPPMLGWR-TPEDRSDP-DACTIS--KDHGYTIYSTFGAFYIPLL 209

Query: 208 VMTILYCRIYRETEKRTK 225
           +M +LY RI+R    R +
Sbjct: 210 LMLVLYGRIFRAARFRIR 227



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 32/88 (36%), Positives = 53/88 (60%), Gaps = 2/88 (2%)

Query: 429 RKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC--VPVTLWHLGYWLCYV 486
           ++++ L +ERK  +TL  I+  FI+ W P+ I+ LV  FC+    +P  L  +  WL Y 
Sbjct: 332 KRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYS 391

Query: 487 NSTVNPICYALCNRTFRKTFKMLLLCRW 514
           NS +NP+ YA  N+ F+  FK ++ C++
Sbjct: 392 NSLLNPVIYAYFNKDFQNAFKKIIKCKF 419


>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
          Length = 572

 Score =  127 bits (318), Expect = 3e-29
 Identities = 61/197 (30%), Positives = 107/197 (54%), Gaps = 5/197 (2%)

Query: 31  ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90
           + +    A   L+ + GN+LV++S   N  L+TV NY++++LA ADL++    +    T 
Sbjct: 97  VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156

Query: 91  ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIM 150
            ++G WA G   CD+W A+D +   AS+++L  IS DRY  +   L Y A  T ++A  +
Sbjct: 157 EVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAI 216

Query: 151 IGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMT 210
           + L W+++ ++    +L W     K  VP DE       E      +++ +FY+P++V+ 
Sbjct: 217 LALLWVVALVVSVGPLLGW-----KEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIV 271

Query: 211 ILYCRIYRETEKRTKDL 227
           ++YCR+Y      T+ L
Sbjct: 272 VMYCRVYVVARSTTRSL 288



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 31/112 (27%), Positives = 60/112 (53%), Gaps = 4/112 (3%)

Query: 417 GLNPNPSHQMTKRKRVVLVK---ERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVP 473
           G+     H       V L+K   E+KAA+TL+ ++  F++ W P+  ++ + +   +  P
Sbjct: 320 GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKP 379

Query: 474 VT-LWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLY 524
              ++ + +WL Y NS VNP+ Y   +R F++ F  LL C+ ++++    L+
Sbjct: 380 SEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLW 431


>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
          Length = 477

 Score =  124 bits (312), Expect = 2e-28
 Identities = 63/216 (29%), Positives = 119/216 (55%), Gaps = 6/216 (2%)

Query: 16  PVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACA 75
           P +  P    + W    +  + A++ L+ + GNVLV+++     +L+T+ N +++SLA A
Sbjct: 45  PASESPEPLSQQWTA-GMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASA 103

Query: 76  DLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRP 135
           DL++G+  +    T ++ GRW  GS  C+LW ++D +   AS+  L VI+ DRY +IT P
Sbjct: 104 DLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSP 163

Query: 136 LTYRAKRTPKRAGIMIGLAWLIS-FILWAPAILCW---QYLVGKRTVPLDECQIQFLSEP 191
             Y++  T  RA  ++   W IS  + + P ++ W   +    +R     +C   F++  
Sbjct: 164 FRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKC-CDFVTNR 222

Query: 192 TITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDL 227
                +++ +FY+P+ +M  +Y R++RE +K+ K +
Sbjct: 223 AYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKI 258



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 4/112 (3%)

Query: 404 PCPFPVAKEPSTKGLN-PNPSHQMTKRK--RVVLVKERKAAQTLSAILLAFIITWTPYNI 460
           P P P    P+      P  + +  KR+  R+V ++E+KA +TL  I+  F + W P+ +
Sbjct: 283 PAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFL 342

Query: 461 MVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLC 512
             +V  F  + VP  L+    WL Y NS  NPI Y   +  FRK F+ LL C
Sbjct: 343 ANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  124 bits (311), Expect = 2e-28
 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%)

Query: 20  QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79
           QP     + + I +  +   + L  ++GN+LV++S   +  L +V +YY+++LA ADL++
Sbjct: 16  QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75

Query: 80  GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139
               +     + ++G WA G + C++W A+D +   AS+M L +IS DRY  ++ PL Y 
Sbjct: 76  TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135

Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199
              T +R  + +   W +S ++    +  W     ++  P DE   Q   EP     +A+
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190

Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245
            +FY+P++++ ++YCR+Y   ++ ++ L      D   S+ VT    RK A
Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%)

Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494
           +E+KAA+TL  ++  F++ W P+ +++ + +F     P  T++ + +WL Y+NS +NPI 
Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325

Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518
           Y   ++ F+K F+ +L    LCR +  K
Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  124 bits (311), Expect = 2e-28
 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%)

Query: 20  QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79
           QP     + + I +  +   + L  ++GN+LV++S   +  L +V +YY+++LA ADL++
Sbjct: 16  QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75

Query: 80  GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139
               +     + ++G WA G + C++W A+D +   AS+M L +IS DRY  ++ PL Y 
Sbjct: 76  TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135

Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199
              T +R  + +   W +S ++    +  W     ++  P DE   Q   EP     +A+
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190

Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245
            +FY+P++++ ++YCR+Y   ++ ++ L      D   S+ VT    RK A
Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%)

Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494
           +E+KAA+TL  ++  F++ W P+ +++ + +F     P  T++ + +WL Y+NS +NPI 
Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325

Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518
           Y   ++ F+K F+ +L    LCR +  K
Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  124 bits (311), Expect = 2e-28
 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%)

Query: 20  QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79
           QP     + + I +  +   + L  ++GN+LV++S   +  L +V +YY+++LA ADL++
Sbjct: 16  QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75

Query: 80  GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139
               +     + ++G WA G + C++W A+D +   AS+M L +IS DRY  ++ PL Y 
Sbjct: 76  TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135

Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199
              T +R  + +   W +S ++    +  W     ++  P DE   Q   EP     +A+
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190

Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245
            +FY+P++++ ++YCR+Y   ++ ++ L      D   S+ VT    RK A
Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%)

Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494
           +E+KAA+TL  ++  F++ W P+ +++ + +F     P  T++ + +WL Y+NS +NPI 
Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325

Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518
           Y   ++ F+K F+ +L    LCR +  K
Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  124 bits (311), Expect = 2e-28
 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%)

Query: 20  QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79
           QP     + + I +  +   + L  ++GN+LV++S   +  L +V +YY+++LA ADL++
Sbjct: 16  QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75

Query: 80  GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139
               +     + ++G WA G + C++W A+D +   AS+M L +IS DRY  ++ PL Y 
Sbjct: 76  TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135

Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199
              T +R  + +   W +S ++    +  W     ++  P DE   Q   EP     +A+
Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190

Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245
            +FY+P++++ ++YCR+Y   ++ ++ L      D   S+ VT    RK A
Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%)

Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494
           +E+KAA+TL  ++  F++ W P+ +++ + +F     P  T++ + +WL Y+NS +NPI 
Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325

Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518
           Y   ++ F+K F+ +L    LCR +  K
Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353


>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
           sapiens]
          Length = 377

 Score =  124 bits (310), Expect = 3e-28
 Identities = 69/207 (33%), Positives = 107/207 (51%), Gaps = 4/207 (1%)

Query: 31  ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90
           I++A V +V++L T++ N  V+ +  +  +L T  NY + SLA  DL++ I  M +   Y
Sbjct: 39  ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAY 98

Query: 91  ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIM 150
            +   W  G + CD+WL+ D     AS+++L VI+ DRY++IT  L Y  +RT   A  M
Sbjct: 99  TITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATM 158

Query: 151 IGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMT 210
           I + W IS  +  P +   Q    K    + +C +   S+ + T  +   AFYIP  ++ 
Sbjct: 159 IAIVWAISICISIPPLFWRQ---AKAQEEMSDCLVN-TSQISYTIYSTCGAFYIPSVLLI 214

Query: 211 ILYCRIYRETEKRTKDLADLQGSDSVT 237
           ILY RIYR    R  +   L G    T
Sbjct: 215 ILYGRIYRAARNRILNPPSLYGKRFTT 241



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 35/85 (41%), Positives = 51/85 (60%), Gaps = 2/85 (2%)

Query: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFC-DKC-VPVTLWHLGYWLCY 485
           +RKR+   +ERKA + L  IL AFII W P+ ++ LV   C D C +   L+    WL Y
Sbjct: 287 ERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGY 346

Query: 486 VNSTVNPICYALCNRTFRKTFKMLL 510
           +NS +NPI Y + N  FR+ F+ ++
Sbjct: 347 LNSLINPIIYTVFNEEFRQAFQKIV 371


>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
          Length = 465

 Score =  122 bits (307), Expect = 6e-28
 Identities = 69/234 (29%), Positives = 123/234 (52%), Gaps = 3/234 (1%)

Query: 3   GDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLK 62
           G++  N T   G      P   + L   +T+  +  ++ L+T+ GNVLV+I+   +  LK
Sbjct: 24  GNASWNGTEAPGGGARATP---YSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALK 80

Query: 63  TVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLL 122
              N +L+SLA AD+++    +       +MG W  G   C+++LALD +   +S+++L 
Sbjct: 81  APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140

Query: 123 VISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDE 182
            IS DRY+SIT+ + Y  KRTP+R   +I   W+IS ++  P ++  +   G       E
Sbjct: 141 AISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAE 200

Query: 183 CQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSV 236
            + +   +      + I +F+ P  +M ++Y RIY+  ++RT+     +G D+V
Sbjct: 201 PRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAV 254



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 27/85 (31%), Positives = 48/85 (56%), Gaps = 4/85 (4%)

Query: 436 KERKAAQTLSAILLAFIITWTPYNIM-VLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPIC 494
           +E++    L+ ++  F++ W P+     L +  C   VP TL+   +W  Y NS++NP+ 
Sbjct: 383 REKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVI 440

Query: 495 YALCNRTFRKTFKMLLLCRWKKKKV 519
           Y + N  FR+ FK  +LCR  +K++
Sbjct: 441 YTIFNHDFRRAFKK-ILCRGDRKRI 464


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.132    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,692,533
Number of Sequences: 37866
Number of extensions: 922866
Number of successful extensions: 4875
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 534
Number of HSP's successfully gapped in prelim test: 247
Number of HSP's that attempted gapping in prelim test: 3295
Number of HSP's gapped (non-prelim): 1316
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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