BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] (532 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 1086 0.0 gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 528 e-150 gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 486 e-137 gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 400 e-111 gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 388 e-108 gi|149158709 histamine receptor H1 [Homo sapiens] 194 1e-49 gi|149158706 histamine receptor H1 [Homo sapiens] 194 1e-49 gi|149158704 histamine receptor H1 [Homo sapiens] 194 1e-49 gi|4504491 histamine receptor H1 [Homo sapiens] 194 1e-49 gi|194018562 histamine receptor H3 [Homo sapiens] 156 5e-38 gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 154 3e-37 gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 131 2e-30 gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 128 1e-29 gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 128 1e-29 gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 127 3e-29 gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 127 3e-29 gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 124 2e-28 gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 124 2e-28 gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 124 2e-28 gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 124 2e-28 gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 124 2e-28 gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 124 3e-28 gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 122 6e-28 >gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] Length = 532 Score = 1086 bits (2808), Expect = 0.0 Identities = 532/532 (100%), Positives = 532/532 (100%) Query: 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 60 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ Sbjct: 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 60 Query: 61 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 120 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN Sbjct: 61 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 120 Query: 121 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 180 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL Sbjct: 121 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 180 Query: 181 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE 240 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE Sbjct: 181 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE 240 Query: 241 KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL 300 KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL Sbjct: 241 KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL 300 Query: 301 TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN 360 TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN Sbjct: 301 TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN 360 Query: 361 YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP 420 YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP Sbjct: 361 YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP 420 Query: 421 NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG 480 NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG Sbjct: 421 NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG 480 Query: 481 YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 532 YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP Sbjct: 481 YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 532 >gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] Length = 590 Score = 528 bits (1359), Expect = e-150 Identities = 288/545 (52%), Positives = 358/545 (65%), Gaps = 37/545 (6%) Query: 8 NATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNY 67 N ++ +GT PL H +W+V+ IA +T +++L+TI+GN+LV++SFKVN QLKTVNNY Sbjct: 48 NFSSPDGT--TDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105 Query: 68 YLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFD 127 +LLSLACADLIIG+ SMNL+TTYI+M RWALG+LACDLWLA+DYVASNASVMNLLVISFD Sbjct: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165 Query: 128 RYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQF 187 RYFSITRPLTYRAKRT KRAG+MIGLAW+ISF+LWAPAIL WQY VGKRTVP EC IQF Sbjct: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225 Query: 188 LSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAH- 246 LSEPTITFGTAIAAFY+PV++MTILY RIY+ETEKRTK+LA LQ S T+AE H Sbjct: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASG--TEAETENFVHP 283 Query: 247 RALFRSCLRCPRPTLAQRERNQAS------WSSSRRSTSTTGKPSQATGPSANWAKAEQL 300 RSC + + N+ W +++ ++ + Q S +W + Sbjct: 284 TGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAA 343 Query: 301 TTCSSYPSSEDED-KPATDPVLQVVYKSQGKES---------------PGEEFSAEETEE 344 + + SS++ED T + +V K G + P EE + E Sbjct: 344 ASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLER 403 Query: 345 TFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMP 404 K + +KS D ++ PKS + + V + N+ K Sbjct: 404 KADKLQAQKSVDDGGSF---------PKSFSKLPIQLESAVDTAKTSDVNSSVGK-STAT 453 Query: 405 CPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLV 464 P + K Q+TKRKR+ LVKE+KAAQTLSAILLAFIITWTPYNIMVLV Sbjct: 454 LPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLV 513 Query: 465 STFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLY 524 +TFCD C+P T W+LGYWLCY+NSTVNP+CYALCN+TFR TFKMLLLC+ KKK ++ Y Sbjct: 514 NTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQY 573 Query: 525 WQGNS 529 Q S Sbjct: 574 QQRQS 578 >gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] Length = 460 Score = 486 bits (1252), Expect = e-137 Identities = 257/491 (52%), Positives = 317/491 (64%), Gaps = 72/491 (14%) Query: 28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87 W+V I T ++SL T+ GN+LV+ISFKVN++LKTVNNY+LLSLACADLIIG FSMNLY Sbjct: 23 WQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLY 82 Query: 88 TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147 TTY+LMG WALG+LACDLWLALDYVASNASVMNLL+ISFDRYFS+TRPL+YRAKRTP+RA Sbjct: 83 TTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRA 142 Query: 148 GIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVS 207 +MIGLAWL+SF+LWAPAIL WQYLVG+RTV +C IQFLS+P ITFGTA+AAFY+PV+ Sbjct: 143 ALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVT 202 Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267 VM LY RIYRETE R ++LA LQGS++ K Sbjct: 203 VMCTLYWRIYRETENRARELAALQGSETPGKG---------------------------G 235 Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327 +S SS R G P G +A +L S+ E+ED+ + ++ + S Sbjct: 236 GSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGS----MESLTSS 291 Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387 +G+E E + +A T++ +PN + P Sbjct: 292 EGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRP---------------------- 329 Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAI 447 T G ++ + KG P Q+ KRK LVKE+KAA+TLSAI Sbjct: 330 -----TKKG--------------RDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAI 370 Query: 448 LLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFK 507 LLAFI+TWTPYNIMVLVSTFC CVP TLW LGYWLCYVNST+NP+CYALCN+ FR TF+ Sbjct: 371 LLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFR 430 Query: 508 MLLLCRWKKKK 518 +LLLCRW K++ Sbjct: 431 LLLLCRWDKRR 441 >gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] Length = 479 Score = 400 bits (1027), Expect = e-111 Identities = 243/534 (45%), Positives = 308/534 (57%), Gaps = 89/534 (16%) Query: 8 NATTVNGTPVNHQPL-------ERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ 60 N T VNG+ N R+ E++ IA VT +SL+T+VGN+LVM+S KVN Q Sbjct: 3 NFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ 62 Query: 61 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN 120 L+TVNNY+L SLACADLIIG FSMNLYT YI+ G W LG++ CDLWLALDYV SNASVMN Sbjct: 63 LQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMN 122 Query: 121 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL 180 LL+ISFDRYF +T+PLTY A+RT K AG+MI AW++SF+LWAPAIL WQ++VGKRTVP Sbjct: 123 LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD 182 Query: 181 DECQIQFLSEPTITFGTAIAAFYIPVSVMTILY--------CRIYRE-----TEKRTKDL 227 ++C IQFLS P +TFGTAIAAFY+PV +MT+LY R+++ EK+ K L Sbjct: 183 NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL 242 Query: 228 ADLQG---SDSVTKAEKRKPAHRALFRSCL-RCPRPTLAQRERNQASWSSSRRSTSTTGK 283 A L+ SV K + A L L P P L R A +S S+S + Sbjct: 243 AFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSAT 302 Query: 284 PSQATGPSANWAKAEQLTTCSSYPSSEDED-KPATD-PVLQVVYKSQGKESPGEEFSAEE 341 + P+ + E T P + PA+ +Q+V K G E Sbjct: 303 QNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNEC--------V 354 Query: 342 TEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVK 401 T V A TP A RP + VA KF + + NQ Sbjct: 355 TAIEIVPA--------TP-------AGMRPAAN--VARKFASIAR---NQ---------- 384 Query: 402 IMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIM 461 V K+ QM R+R K +T+ AILLAFI+TWTPYN+M Sbjct: 385 -------VRKK-----------RQMAARER-------KVTRTIFAILLAFILTWTPYNVM 419 Query: 462 VLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWK 515 VLV+TFC C+P T+W +GYWLCYVNST+NP CYALCN TF+KTF+ LLLC+++ Sbjct: 420 VLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR 473 >gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] Length = 466 Score = 388 bits (997), Expect = e-108 Identities = 218/503 (43%), Positives = 278/503 (55%), Gaps = 72/503 (14%) Query: 25 HRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSM 84 ++ +EV+ I V +SL+TI+GN+LVM+S KVN L+TVNNY+L SLACADLIIG+FSM Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77 Query: 85 NLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTP 144 NLYT Y ++G W LG + CDLWLALDYV SNASVMNLL+ISFDRYF +T+PLTY KRT Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137 Query: 145 KRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYI 204 K AG+MI AW++SFILWAPAIL WQ++VG RTV EC IQF S +TFGTAIAAFY+ Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197 Query: 205 PVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQR 264 PV +MT+LY I R ++ R K D + P +L + + P Sbjct: 198 PVIIMTVLYWHISRASKSRIK-------KDKKEPVANQDPVSPSLVQGRIVKP------- 243 Query: 265 ERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVV 324 + PS G N K DPV + Sbjct: 244 --------------NNNNMPSSDDGLEHN---------------KIQNGKAPRDPVTENC 274 Query: 325 YKSQGKESPGEEFSAEET-----------EETFVKAETEKSDYDTPNYLLSPAAAHRPKS 373 + + KES + S +E V S + PKS Sbjct: 275 VQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKS 334 Query: 374 QKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPF-PVAKEPSTKGLNPNPSHQMTKRKRV 432 C + V Q NG K I+ + K+P+ K P PS Sbjct: 335 DSCTPTNTTVEVVGSSGQ---NGDEKQNIVARKIVKMTKQPAKK--KPPPS--------- 380 Query: 433 VLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNP 492 +E+K +T+ AILLAFIITW PYN+MVL++TFC C+P T+W +GYWLCY+NST+NP Sbjct: 381 ---REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINP 437 Query: 493 ICYALCNRTFRKTFKMLLLCRWK 515 CYALCN TF+KTFK LL+C +K Sbjct: 438 ACYALCNATFKKTFKHLLMCHYK 460 >gi|149158709 histamine receptor H1 [Homo sapiens] Length = 487 Score = 194 bits (494), Expect = 1e-49 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%) Query: 29 EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88 +++ + V + + L+T+ N+LV+ + + +L TV N Y++SL+ ADLI+G M + Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 Query: 89 TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148 Y+LM +W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207 I AW +SF LW IL W + + + +V D+C+ F TAI FY+P Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267 +M Y +IY+ + + + S K +P + P+ A++ Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253 Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327 ++ W +R G S PS K + S + DK P L +V+ Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311 Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387 E ++ A +K + + L + A+ + Q + + Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363 Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440 D ET G K+ + S GL+ SH + + +ERKA Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413 Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500 A+ L I+ AFI+ W PY I +V FC C L WL Y+NST+NP+ Y LCN Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473 Query: 501 TFRKTFKMLLLCR 513 F+KTFK +L R Sbjct: 474 NFKKTFKRILHIR 486 >gi|149158706 histamine receptor H1 [Homo sapiens] Length = 487 Score = 194 bits (494), Expect = 1e-49 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%) Query: 29 EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88 +++ + V + + L+T+ N+LV+ + + +L TV N Y++SL+ ADLI+G M + Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 Query: 89 TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148 Y+LM +W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207 I AW +SF LW IL W + + + +V D+C+ F TAI FY+P Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267 +M Y +IY+ + + + S K +P + P+ A++ Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253 Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327 ++ W +R G S PS K + S + DK P L +V+ Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311 Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387 E ++ A +K + + L + A+ + Q + + Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363 Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440 D ET G K+ + S GL+ SH + + +ERKA Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413 Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500 A+ L I+ AFI+ W PY I +V FC C L WL Y+NST+NP+ Y LCN Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473 Query: 501 TFRKTFKMLLLCR 513 F+KTFK +L R Sbjct: 474 NFKKTFKRILHIR 486 >gi|149158704 histamine receptor H1 [Homo sapiens] Length = 487 Score = 194 bits (494), Expect = 1e-49 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%) Query: 29 EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88 +++ + V + + L+T+ N+LV+ + + +L TV N Y++SL+ ADLI+G M + Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 Query: 89 TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148 Y+LM +W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207 I AW +SF LW IL W + + + +V D+C+ F TAI FY+P Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267 +M Y +IY+ + + + S K +P + P+ A++ Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253 Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327 ++ W +R G S PS K + S + DK P L +V+ Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311 Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387 E ++ A +K + + L + A+ + Q + + Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363 Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440 D ET G K+ + S GL+ SH + + +ERKA Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413 Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500 A+ L I+ AFI+ W PY I +V FC C L WL Y+NST+NP+ Y LCN Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473 Query: 501 TFRKTFKMLLLCR 513 F+KTFK +L R Sbjct: 474 NFKKTFKRILHIR 486 >gi|4504491 histamine receptor H1 [Homo sapiens] Length = 487 Score = 194 bits (494), Expect = 1e-49 Identities = 142/493 (28%), Positives = 223/493 (45%), Gaps = 40/493 (8%) Query: 29 EVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYT 88 +++ + V + + L+T+ N+LV+ + + +L TV N Y++SL+ ADLI+G M + Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85 Query: 89 TYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAG 148 Y+LM +W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145 Query: 149 IMIGLAWLISFILWAPAILCWQYLVGKRTVPL-DECQIQFLSEPTITFGTAIAAFYIPVS 207 I AW +SF LW IL W + + + +V D+C+ F TAI FY+P Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204 Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERN 267 +M Y +IY+ + + + S K +P + P+ A++ Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPEN----------PKGD-AKKPGK 253 Query: 268 QASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKS 327 ++ W +R G S PS K + S + DK P L +V+ Sbjct: 254 ESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMKSPVVFSQEDDREVDKLYCFP-LDIVHMQ 311 Query: 328 QGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKA 387 E ++ A +K + + L + A+ + Q + + Sbjct: 312 AAAEGSSRDYVAVNRSHGQLKTDEQG--------LNTHGASEISEDQMLGDSQSFSRTDS 363 Query: 388 DGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN-------PNPSHQMTKRKRVVLVKERKA 440 D ET G K+ + S GL+ SH + + +ERKA Sbjct: 364 DTTTETAPGKGKL----------RSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKA 413 Query: 441 AQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNR 500 A+ L I+ AFI+ W PY I +V FC C L WL Y+NST+NP+ Y LCN Sbjct: 414 AKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNE 473 Query: 501 TFRKTFKMLLLCR 513 F+KTFK +L R Sbjct: 474 NFKKTFKRILHIR 486 >gi|194018562 histamine receptor H3 [Homo sapiens] Length = 445 Score = 156 bits (394), Expect = 5e-38 Identities = 73/199 (36%), Positives = 123/199 (61%), Gaps = 2/199 (1%) Query: 28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87 W + +AA+ A++ + T++GN LVM++F +S L+T NN++LL+LA +D ++G F + LY Sbjct: 33 WTAV-LAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLY 91 Query: 88 TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKR-TPKR 146 Y+L GRW G C LWL +DY+ +S N+++IS+DR+ S+TR ++YRA++ +R Sbjct: 92 VPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRR 151 Query: 147 AGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPV 206 A + L W+++F+L+ PAIL W+YL G ++P C +F + F+ P Sbjct: 152 AVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPF 211 Query: 207 SVMTILYCRIYRETEKRTK 225 +T IY ++RT+ Sbjct: 212 LSVTFFNLSIYLNIQRRTR 230 Score = 71.2 bits (173), Expect = 2e-12 Identities = 39/111 (35%), Positives = 60/111 (54%), Gaps = 4/111 (3%) Query: 408 PVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTF 467 P A S + S T+R R L ++RK A++L+ I+ F + W PY +++++ Sbjct: 326 PSASSASLEKRMKMVSQSFTQRFR--LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAA 383 Query: 468 CD-KCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKK 517 C CVP + +WL + NS VNP+ Y LC+ +FR+ F LLC K K Sbjct: 384 CHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTK-LLCPQKLK 433 >gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] Length = 450 Score = 154 bits (388), Expect = 3e-37 Identities = 120/485 (24%), Positives = 212/485 (43%), Gaps = 57/485 (11%) Query: 33 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYIL 92 IAA + L TI GN LV+++ + L+ N +L+SLA AD+++ + L Sbjct: 15 IAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANEL 74 Query: 93 MGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIG 152 +G W C+++LALD + +S+++L IS DRY++++R L Y +KRTP+R +I Sbjct: 75 LGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134 Query: 153 LAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTIL 212 WLI+ ++ P ++ Y + P Q + E ++I +F+ P +M ++ Sbjct: 135 TVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILV 191 Query: 213 YCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAH-RALFRSCLRCPRPTLAQRERNQASW 271 Y RIY ++ + +G ++++ +P H AL + L + RE N S Sbjct: 192 YLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSK 251 Query: 272 SSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKE 331 S+ + T + + +WA + P+S K +G Sbjct: 252 STGEKEEGETPEDTGTRALPPSWA---------ALPNSGQGQK-------------EGVC 289 Query: 332 SPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQ 391 E AEE EE E E+ + + +SPA+A P Q+ R++ G Sbjct: 290 GASPEDEAEEEEE----EEEEEEECEPQAVPVSPASACSPPLQQ--PQGSRVLATLRGQV 343 Query: 392 ETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAF 451 G + R+R L +E++ L+ ++ F Sbjct: 344 LLGRGVGAI-----------------------GGQWWRRRAQLTREKRFTFVLAVVIGVF 380 Query: 452 IITWTPYNIMVLVSTFCDK-C-VPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKML 509 ++ W P+ + C K C VP L+ +W+ Y NS++NP+ Y + N+ FR+ F+ + Sbjct: 381 VLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRI 440 Query: 510 LLCRW 514 L W Sbjct: 441 LCRPW 445 >gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sapiens] Length = 390 Score = 131 bits (329), Expect = 2e-30 Identities = 73/213 (34%), Positives = 111/213 (52%), Gaps = 5/213 (2%) Query: 28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87 W+V+ + + A+++L T + N V+ + +L T NY + SLA DL++ I M + Sbjct: 48 WKVLLVMLL-ALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIS 106 Query: 88 TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147 T Y + GRW LG + CD WL+ D AS+++L VI+ DRY++IT + Y AKRTPKRA Sbjct: 107 TMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRA 166 Query: 148 GIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVS 207 +MI L W+ S + P Q K + EC + T + + AFY P Sbjct: 167 AVMIALVWVFSISISLPPFFWRQ---AKAEEEVSECVVN-TDHILYTVYSTVGAFYFPTL 222 Query: 208 VMTILYCRIYRETEKRTKDLADLQGSDSVTKAE 240 ++ LY RIY E R + +T+A+ Sbjct: 223 LLIALYGRIYVEARSRILKQTPNRTGKRLTRAQ 255 Score = 67.8 bits (164), Expect = 2e-11 Identities = 34/90 (37%), Positives = 54/90 (60%), Gaps = 2/90 (2%) Query: 423 SHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFC-DKC-VPVTLWHLG 480 S + ++K+++ +ERKA +TL IL AFI+ W P+ I+ LV C D C + ++ Sbjct: 295 SDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFF 354 Query: 481 YWLCYVNSTVNPICYALCNRTFRKTFKMLL 510 WL Y+NS +NPI Y + N F++ F L+ Sbjct: 355 TWLGYLNSLINPIIYTMSNEDFKQAFHKLI 384 >gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] Length = 413 Score = 128 bits (322), Expect = 1e-29 Identities = 65/233 (27%), Positives = 127/233 (54%), Gaps = 4/233 (1%) Query: 3 GDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLK 62 G ++ A + P + +R +W V+ + V +++ L + GNVLV+ + +L+ Sbjct: 7 GSAFLLAPNRSHAPDHDVTQQRDEVW-VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQ 65 Query: 63 TVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLL 122 TV NY++ SLACADL++G+ + +ILM W G+ C+ W ++D + AS+ L Sbjct: 66 TVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLC 125 Query: 123 VISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFIL-WAPAILCWQYLVGKRTVP-- 179 VI+ DRYF+IT P Y++ T +A ++I + W++S + + P + W + + Sbjct: 126 VIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCY 185 Query: 180 LDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQG 232 +E F + ++I +FY+P+ +M +Y R+++E +++ + + +G Sbjct: 186 ANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEG 238 Score = 49.7 bits (117), Expect = 7e-06 Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 1/86 (1%) Query: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVN 487 +R +KE KA +TL I+ F + W P+ I+ +V D + ++ L W+ YVN Sbjct: 259 RRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVN 318 Query: 488 STVNPICYALCNRTFRKTFKMLLLCR 513 S NP+ Y + FR F+ LL R Sbjct: 319 SGFNPLIYCR-SPDFRIAFQELLCLR 343 >gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] Length = 520 Score = 128 bits (322), Expect = 1e-29 Identities = 68/220 (30%), Positives = 117/220 (53%), Gaps = 6/220 (2%) Query: 8 NATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNY 67 N T N T N L + + I++ V L IVGN+LV++S N L+T NY Sbjct: 24 NFTGPNQTSSN-STLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNY 82 Query: 68 YLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFD 127 ++++LA ADL++ + ++G W LG + CD+W A+D + AS+++L IS D Sbjct: 83 FIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISID 142 Query: 128 RYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQF 187 RY + L Y T ++A + + W++S ++ +L W K P D+ + Sbjct: 143 RYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGW-----KEPAPNDDKECGV 197 Query: 188 LSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDL 227 EP +++ +FYIP++V+ ++YCR+Y ++ TK+L Sbjct: 198 TEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNL 237 Score = 57.8 bits (138), Expect = 2e-08 Identities = 34/101 (33%), Positives = 54/101 (53%), Gaps = 2/101 (1%) Query: 414 STKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMV-LVSTFCDKCV 472 STK NP + K +E+KAA+TL ++ FI+ W P+ I + L S F Sbjct: 267 STKAKGHNPRSSIAV-KLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKP 325 Query: 473 PVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCR 513 P ++ + +WL Y NS +NPI Y ++ F++ F +L C+ Sbjct: 326 PDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQ 366 >gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sapiens] Length = 422 Score = 127 bits (319), Expect = 3e-29 Identities = 68/198 (34%), Positives = 114/198 (57%), Gaps = 5/198 (2%) Query: 28 WEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLY 87 ++VIT + ++ ++GN V+ + + L+ V NY + SLA DL++ + + + Sbjct: 35 YQVITSLLLGTLI-FCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMA 93 Query: 88 TTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 147 Y ++ +W LG + CDL++ALD + +S+++L I+ DRY++IT P+ Y KRTP+RA Sbjct: 94 ALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRA 153 Query: 148 GIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVS 207 +I L WLI F++ P +L W+ R+ P D C I + T + AFYIP+ Sbjct: 154 AALISLTWLIGFLISIPPMLGWR-TPEDRSDP-DACTIS--KDHGYTIYSTFGAFYIPLL 209 Query: 208 VMTILYCRIYRETEKRTK 225 +M +LY RI+R R + Sbjct: 210 LMLVLYGRIFRAARFRIR 227 Score = 70.5 bits (171), Expect = 4e-12 Identities = 32/88 (36%), Positives = 53/88 (60%), Gaps = 2/88 (2%) Query: 429 RKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKC--VPVTLWHLGYWLCYV 486 ++++ L +ERK +TL I+ FI+ W P+ I+ LV FC+ +P L + WL Y Sbjct: 332 KRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYS 391 Query: 487 NSTVNPICYALCNRTFRKTFKMLLLCRW 514 NS +NP+ YA N+ F+ FK ++ C++ Sbjct: 392 NSLLNPVIYAYFNKDFQNAFKKIIKCKF 419 >gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] Length = 572 Score = 127 bits (318), Expect = 3e-29 Identities = 61/197 (30%), Positives = 107/197 (54%), Gaps = 5/197 (2%) Query: 31 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90 + + A L+ + GN+LV++S N L+TV NY++++LA ADL++ + T Sbjct: 97 VGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATM 156 Query: 91 ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIM 150 ++G WA G CD+W A+D + AS+++L IS DRY + L Y A T ++A + Sbjct: 157 EVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAI 216 Query: 151 IGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMT 210 + L W+++ ++ +L W K VP DE E +++ +FY+P++V+ Sbjct: 217 LALLWVVALVVSVGPLLGW-----KEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIV 271 Query: 211 ILYCRIYRETEKRTKDL 227 ++YCR+Y T+ L Sbjct: 272 VMYCRVYVVARSTTRSL 288 Score = 58.2 bits (139), Expect = 2e-08 Identities = 31/112 (27%), Positives = 60/112 (53%), Gaps = 4/112 (3%) Query: 417 GLNPNPSHQMTKRKRVVLVK---ERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVP 473 G+ H V L+K E+KAA+TL+ ++ F++ W P+ ++ + + + P Sbjct: 320 GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKP 379 Query: 474 VT-LWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLY 524 ++ + +WL Y NS VNP+ Y +R F++ F LL C+ ++++ L+ Sbjct: 380 SEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLW 431 >gi|4557265 beta-1-adrenergic receptor [Homo sapiens] Length = 477 Score = 124 bits (312), Expect = 2e-28 Identities = 63/216 (29%), Positives = 119/216 (55%), Gaps = 6/216 (2%) Query: 16 PVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACA 75 P + P + W + + A++ L+ + GNVLV+++ +L+T+ N +++SLA A Sbjct: 45 PASESPEPLSQQWTA-GMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASA 103 Query: 76 DLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRP 135 DL++G+ + T ++ GRW GS C+LW ++D + AS+ L VI+ DRY +IT P Sbjct: 104 DLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSP 163 Query: 136 LTYRAKRTPKRAGIMIGLAWLIS-FILWAPAILCW---QYLVGKRTVPLDECQIQFLSEP 191 Y++ T RA ++ W IS + + P ++ W + +R +C F++ Sbjct: 164 FRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKC-CDFVTNR 222 Query: 192 TITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDL 227 +++ +FY+P+ +M +Y R++RE +K+ K + Sbjct: 223 AYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKI 258 Score = 60.1 bits (144), Expect = 5e-09 Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 4/112 (3%) Query: 404 PCPFPVAKEPSTKGLN-PNPSHQMTKRK--RVVLVKERKAAQTLSAILLAFIITWTPYNI 460 P P P P+ P + + KR+ R+V ++E+KA +TL I+ F + W P+ + Sbjct: 283 PAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFL 342 Query: 461 MVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLC 512 +V F + VP L+ WL Y NS NPI Y + FRK F+ LL C Sbjct: 343 ANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393 >gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] Length = 455 Score = 124 bits (311), Expect = 2e-28 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%) Query: 20 QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79 QP + + I + + + L ++GN+LV++S + L +V +YY+++LA ADL++ Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75 Query: 80 GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139 + + ++G WA G + C++W A+D + AS+M L +IS DRY ++ PL Y Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135 Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199 T +R + + W +S ++ + W ++ P DE Q EP +A+ Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190 Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245 +FY+P++++ ++YCR+Y ++ ++ L D S+ VT RK A Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241 Score = 60.1 bits (144), Expect = 5e-09 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%) Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494 +E+KAA+TL ++ F++ W P+ +++ + +F P T++ + +WL Y+NS +NPI Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325 Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518 Y ++ F+K F+ +L LCR + K Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353 >gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] Length = 466 Score = 124 bits (311), Expect = 2e-28 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%) Query: 20 QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79 QP + + I + + + L ++GN+LV++S + L +V +YY+++LA ADL++ Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75 Query: 80 GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139 + + ++G WA G + C++W A+D + AS+M L +IS DRY ++ PL Y Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135 Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199 T +R + + W +S ++ + W ++ P DE Q EP +A+ Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190 Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245 +FY+P++++ ++YCR+Y ++ ++ L D S+ VT RK A Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241 Score = 60.1 bits (144), Expect = 5e-09 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%) Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494 +E+KAA+TL ++ F++ W P+ +++ + +F P T++ + +WL Y+NS +NPI Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325 Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518 Y ++ F+K F+ +L LCR + K Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353 >gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] Length = 475 Score = 124 bits (311), Expect = 2e-28 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%) Query: 20 QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79 QP + + I + + + L ++GN+LV++S + L +V +YY+++LA ADL++ Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75 Query: 80 GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139 + + ++G WA G + C++W A+D + AS+M L +IS DRY ++ PL Y Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135 Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199 T +R + + W +S ++ + W ++ P DE Q EP +A+ Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190 Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245 +FY+P++++ ++YCR+Y ++ ++ L D S+ VT RK A Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241 Score = 60.1 bits (144), Expect = 5e-09 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%) Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494 +E+KAA+TL ++ F++ W P+ +++ + +F P T++ + +WL Y+NS +NPI Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325 Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518 Y ++ F+K F+ +L LCR + K Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353 >gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] Length = 429 Score = 124 bits (311), Expect = 2e-28 Identities = 65/231 (28%), Positives = 121/231 (52%), Gaps = 10/231 (4%) Query: 20 QPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLII 79 QP + + I + + + L ++GN+LV++S + L +V +YY+++LA ADL++ Sbjct: 16 QPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLL 75 Query: 80 GIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYR 139 + + ++G WA G + C++W A+D + AS+M L +IS DRY ++ PL Y Sbjct: 76 TSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP 135 Query: 140 AKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAI 199 T +R + + W +S ++ + W ++ P DE Q EP +A+ Sbjct: 136 TIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQINEEPGYVLFSAL 190 Query: 200 AAFYIPVSVMTILYCRIYRETEKRTKDL-----ADLQGSDSVTKAEKRKPA 245 +FY+P++++ ++YCR+Y ++ ++ L D S+ VT RK A Sbjct: 191 GSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNA 241 Score = 60.1 bits (144), Expect = 5e-09 Identities = 29/88 (32%), Positives = 54/88 (61%), Gaps = 5/88 (5%) Query: 436 KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPV-TLWHLGYWLCYVNSTVNPIC 494 +E+KAA+TL ++ F++ W P+ +++ + +F P T++ + +WL Y+NS +NPI Sbjct: 266 REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPII 325 Query: 495 YALCNRTFRKTFKMLL----LCRWKKKK 518 Y ++ F+K F+ +L LCR + K Sbjct: 326 YPCSSQEFKKAFQNVLRIQCLCRKQSSK 353 >gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sapiens] Length = 377 Score = 124 bits (310), Expect = 3e-28 Identities = 69/207 (33%), Positives = 107/207 (51%), Gaps = 4/207 (1%) Query: 31 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTY 90 I++A V +V++L T++ N V+ + + +L T NY + SLA DL++ I M + Y Sbjct: 39 ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAY 98 Query: 91 ILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIM 150 + W G + CD+WL+ D AS+++L VI+ DRY++IT L Y +RT A M Sbjct: 99 TITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATM 158 Query: 151 IGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMT 210 I + W IS + P + Q K + +C + S+ + T + AFYIP ++ Sbjct: 159 IAIVWAISICISIPPLFWRQ---AKAQEEMSDCLVN-TSQISYTIYSTCGAFYIPSVLLI 214 Query: 211 ILYCRIYRETEKRTKDLADLQGSDSVT 237 ILY RIYR R + L G T Sbjct: 215 ILYGRIYRAARNRILNPPSLYGKRFTT 241 Score = 67.4 bits (163), Expect = 3e-11 Identities = 35/85 (41%), Positives = 51/85 (60%), Gaps = 2/85 (2%) Query: 428 KRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFC-DKC-VPVTLWHLGYWLCY 485 +RKR+ +ERKA + L IL AFII W P+ ++ LV C D C + L+ WL Y Sbjct: 287 ERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGY 346 Query: 486 VNSTVNPICYALCNRTFRKTFKMLL 510 +NS +NPI Y + N FR+ F+ ++ Sbjct: 347 LNSLINPIIYTVFNEEFRQAFQKIV 371 >gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] Length = 465 Score = 122 bits (307), Expect = 6e-28 Identities = 69/234 (29%), Positives = 123/234 (52%), Gaps = 3/234 (1%) Query: 3 GDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLK 62 G++ N T G P + L +T+ + ++ L+T+ GNVLV+I+ + LK Sbjct: 24 GNASWNGTEAPGGGARATP---YSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALK 80 Query: 63 TVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLL 122 N +L+SLA AD+++ + +MG W G C+++LALD + +S+++L Sbjct: 81 APQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLC 140 Query: 123 VISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDE 182 IS DRY+SIT+ + Y KRTP+R +I W+IS ++ P ++ + G E Sbjct: 141 AISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAE 200 Query: 183 CQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSV 236 + + + + I +F+ P +M ++Y RIY+ ++RT+ +G D+V Sbjct: 201 PRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAV 254 Score = 56.2 bits (134), Expect = 7e-08 Identities = 27/85 (31%), Positives = 48/85 (56%), Gaps = 4/85 (4%) Query: 436 KERKAAQTLSAILLAFIITWTPYNIM-VLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPIC 494 +E++ L+ ++ F++ W P+ L + C VP TL+ +W Y NS++NP+ Sbjct: 383 REKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCS--VPRTLFKFFFWFGYCNSSLNPVI 440 Query: 495 YALCNRTFRKTFKMLLLCRWKKKKV 519 Y + N FR+ FK +LCR +K++ Sbjct: 441 YTIFNHDFRRAFKK-ILCRGDRKRI 464 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.132 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,692,533 Number of Sequences: 37866 Number of extensions: 922866 Number of successful extensions: 4875 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 534 Number of HSP's successfully gapped in prelim test: 247 Number of HSP's that attempted gapping in prelim test: 3295 Number of HSP's gapped (non-prelim): 1316 length of query: 532 length of database: 18,247,518 effective HSP length: 107 effective length of query: 425 effective length of database: 14,195,856 effective search space: 6033238800 effective search space used: 6033238800 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.