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Search of human proteins with 13899295
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
(250 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ... 512 e-145
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [... 144 7e-35
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15... 125 3e-29
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ... 122 4e-28
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ... 122 4e-28
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ... 122 4e-28
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 97 1e-20
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 97 1e-20
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ... 90 2e-18
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 86 4e-17
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 84 9e-17
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 84 9e-17
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [... 71 8e-13
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [... 71 8e-13
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ... 67 2e-11
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is... 67 2e-11
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10... 67 2e-11
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 66 3e-11
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14... 58 9e-09
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [... 57 2e-08
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 51 8e-07
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 51 8e-07
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 51 8e-07
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 48 9e-06
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 48 9e-06
gi|155029533 membrane-spanning 4-domains, subfamily A, member 13... 47 1e-05
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14... 42 7e-04
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i... 40 0.001
gi|38146116 hypothetical protein LOC10712 isoform a [Homo sapiens] 35 0.080
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 32 0.40
>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
Length = 250
Score = 512 bits (1319), Expect = e-145
Identities = 250/250 (100%), Positives = 250/250 (100%)
Query: 1 MNSMTSAVPVANSVLVVAPHNGYPVTPGIMSHVPLYPNSQPQVHLVPGNPPSLVSNVNGQ 60
MNSMTSAVPVANSVLVVAPHNGYPVTPGIMSHVPLYPNSQPQVHLVPGNPPSLVSNVNGQ
Sbjct: 1 MNSMTSAVPVANSVLVVAPHNGYPVTPGIMSHVPLYPNSQPQVHLVPGNPPSLVSNVNGQ 60
Query: 61 PVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGS 120
PVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGS
Sbjct: 61 PVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGS 120
Query: 121 LSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNP 180
LSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNP
Sbjct: 121 LSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNP 180
Query: 181 GMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPVTSPP 240
GMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPVTSPP
Sbjct: 181 GMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPVTSPP 240
Query: 241 SYSSEIQANK 250
SYSSEIQANK
Sbjct: 241 SYSSEIQANK 250
>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
Length = 267
Score = 144 bits (363), Expect = 7e-35
Identities = 91/211 (43%), Positives = 126/211 (59%), Gaps = 18/211 (8%)
Query: 35 LYPNSQPQVHLVPGNPPSLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVL 94
++ +SQP + PS+ G V +E K LG IQI++GL HIG G ++ +
Sbjct: 59 IFASSQPGQGNIQMINPSV-----GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLIS 113
Query: 95 -----VGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICS 149
V + S + GG+PFWGGL FIISGSLSV+A + S CL+ GSLG+NIVS+I +
Sbjct: 114 FSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKE-LSRCLVKGSLGMNIVSSILA 172
Query: 150 AVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQL 209
+GVIL + D+ I + A DY W V G IS L++F LLEF +ACA++HF Q
Sbjct: 173 FIGVILLLVDMCI-NGVAGQDY----WAVLSGKGISATLMIFSLLEFFVACATAHFANQA 227
Query: 210 VCCQSSNVSVIYPNIYAANPVITPEPVTSPP 240
+ +V VI PN+Y +NPV TP ++PP
Sbjct: 228 NTTTNMSVLVI-PNMYESNPV-TPASSSAPP 256
>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
isoform 1 [Homo sapiens]
Length = 240
Score = 125 bits (315), Expect = 3e-29
Identities = 85/245 (34%), Positives = 118/245 (48%), Gaps = 20/245 (8%)
Query: 6 SAVPVANSVLVVAPHN---GYPVTPGIMSHVPLYPNSQPQVHLVP--GNPPSLVSNVNGQ 60
SA P +N V VV P N G P I+ P Q P P + +
Sbjct: 2 SAAPASNGVFVVIPPNNASGLCPPPAILPTSMCQPPGIMQFEEPPLGAQTPRATQPPDLR 61
Query: 61 PVQKALK-EGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISG 119
PV+ L E K LG +QI+IGL H+G GS++ V G GG PFWGG FIISG
Sbjct: 62 PVETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHVGIFFIEGGVPFWGGACFIISG 121
Query: 120 SLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVN 179
SLSVAAE ++ CL+ SLG NI+S + + G + + D + + Y
Sbjct: 122 SLSVAAEKN-HTSCLVRSSLGTNILSVMAAFAGTAILLMDFGVTNRDVDRGYL------- 173
Query: 180 PGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPVTSP 239
VL +F +LEF A + HFGCQ + Q+S + PN ++A+ I ++P
Sbjct: 174 ------AVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLPNAFSADFNIPSPAASAP 227
Query: 240 PSYSS 244
P+Y +
Sbjct: 228 PAYDN 232
>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 122 bits (305), Expect = 4e-28
Identities = 95/261 (36%), Positives = 130/261 (49%), Gaps = 44/261 (16%)
Query: 3 SMTSAVPVANSVL-VVAPHNGYPVTPGIM---------SHVPLYPNSQPQVHLVPGNP-- 50
+MT V ANSV ++AP N + + P S V YP S +H G
Sbjct: 57 TMTEQVIGANSVPGIIAPDNVHVIQPSNPVASGNHLQPSEVTTYPISPKVIHCDTGRANL 116
Query: 51 -------PSLVSNVNGQPV----QKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYL 99
+ + V QP+ Q + AIQI+IGL HI S + VL Y
Sbjct: 117 QNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTAIQILIGLTHIF--SAINPVLY-YYP 173
Query: 100 SISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITD 159
+++ G+P WGGL +I+SGSLSV A P S C+++ S+ NI+SA+ + G+ + ITD
Sbjct: 174 FVTWLSGYPLWGGLSYIVSGSLSVWAAKDP-SPCVVNSSISFNIISALFAFAGIFIIITD 232
Query: 160 LSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCC-QSSNVS 218
LS+ + Y A+SG LL F LLEF + C SHFGCQ CC Q NV+
Sbjct: 233 LSLYYVTTY------------SKAVSGGLLPFALLEFILTCVVSHFGCQATCCRQFENVA 280
Query: 219 VIYPNIYAANPVITPEPVTSP 239
VI P +++ NP T TSP
Sbjct: 281 VI-PTVFSFNPANT---TTSP 297
>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 122 bits (305), Expect = 4e-28
Identities = 95/261 (36%), Positives = 130/261 (49%), Gaps = 44/261 (16%)
Query: 3 SMTSAVPVANSVL-VVAPHNGYPVTPGIM---------SHVPLYPNSQPQVHLVPGNP-- 50
+MT V ANSV ++AP N + + P S V YP S +H G
Sbjct: 57 TMTEQVIGANSVPGIIAPDNVHVIQPSNPVASGNHLQPSEVTTYPISPKVIHCDTGRANL 116
Query: 51 -------PSLVSNVNGQPV----QKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYL 99
+ + V QP+ Q + AIQI+IGL HI S + VL Y
Sbjct: 117 QNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTAIQILIGLTHIF--SAINPVLY-YYP 173
Query: 100 SISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITD 159
+++ G+P WGGL +I+SGSLSV A P S C+++ S+ NI+SA+ + G+ + ITD
Sbjct: 174 FVTWLSGYPLWGGLSYIVSGSLSVWAAKDP-SPCVVNSSISFNIISALFAFAGIFIIITD 232
Query: 160 LSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCC-QSSNVS 218
LS+ + Y A+SG LL F LLEF + C SHFGCQ CC Q NV+
Sbjct: 233 LSLYYVTTY------------SKAVSGGLLPFALLEFILTCVVSHFGCQATCCRQFENVA 280
Query: 219 VIYPNIYAANPVITPEPVTSP 239
VI P +++ NP T TSP
Sbjct: 281 VI-PTVFSFNPANT---TTSP 297
>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 122 bits (305), Expect = 4e-28
Identities = 95/261 (36%), Positives = 130/261 (49%), Gaps = 44/261 (16%)
Query: 3 SMTSAVPVANSVL-VVAPHNGYPVTPGIM---------SHVPLYPNSQPQVHLVPGNP-- 50
+MT V ANSV ++AP N + + P S V YP S +H G
Sbjct: 57 TMTEQVIGANSVPGIIAPDNVHVIQPSNPVASGNHLQPSEVTTYPISPKVIHCDTGRANL 116
Query: 51 -------PSLVSNVNGQPV----QKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYL 99
+ + V QP+ Q + AIQI+IGL HI S + VL Y
Sbjct: 117 QNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTAIQILIGLTHIF--SAINPVLY-YYP 173
Query: 100 SISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITD 159
+++ G+P WGGL +I+SGSLSV A P S C+++ S+ NI+SA+ + G+ + ITD
Sbjct: 174 FVTWLSGYPLWGGLSYIVSGSLSVWAAKDP-SPCVVNSSISFNIISALFAFAGIFIIITD 232
Query: 160 LSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCC-QSSNVS 218
LS+ + Y A+SG LL F LLEF + C SHFGCQ CC Q NV+
Sbjct: 233 LSLYYVTTY------------SKAVSGGLLPFALLEFILTCVVSHFGCQATCCRQFENVA 280
Query: 219 VIYPNIYAANPVITPEPVTSP 239
VI P +++ NP T TSP
Sbjct: 281 VI-PTVFSFNPANT---TTSP 297
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 97.1 bits (240), Expect = 1e-20
Identities = 67/184 (36%), Positives = 102/184 (55%), Gaps = 13/184 (7%)
Query: 63 QKALK-EGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISG 119
+K LK E K LG +QI+ L + +G M + Y S IS Y G+ WG + FIISG
Sbjct: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISG 96
Query: 120 SLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL---SIPHPYAYPDYYPYAW 176
SLS+AA + + L+ GSLG+NI S++ +A G+++ L S HPY +YY +
Sbjct: 97 SLSIAAGIRT-TKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYC--NYYGNSN 153
Query: 177 GVNPGMAI----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVIT 232
+ M+I G++L+ +LEF IA + S FGC+++CC V +I P+ +
Sbjct: 154 NCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETAS 213
Query: 233 PEPV 236
P P+
Sbjct: 214 PTPL 217
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 97.1 bits (240), Expect = 1e-20
Identities = 67/184 (36%), Positives = 102/184 (55%), Gaps = 13/184 (7%)
Query: 63 QKALK-EGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISG 119
+K LK E K LG +QI+ L + +G M + Y S IS Y G+ WG + FIISG
Sbjct: 56 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISG 115
Query: 120 SLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL---SIPHPYAYPDYYPYAW 176
SLS+AA + + L+ GSLG+NI S++ +A G+++ L S HPY +YY +
Sbjct: 116 SLSIAAGIRT-TKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYC--NYYGNSN 172
Query: 177 GVNPGMAI----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVIT 232
+ M+I G++L+ +LEF IA + S FGC+++CC V +I P+ +
Sbjct: 173 NCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETAS 232
Query: 233 PEPV 236
P P+
Sbjct: 233 PTPL 236
>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
isoform 2 [Homo sapiens]
Length = 147
Score = 90.1 bits (222), Expect = 2e-18
Identities = 51/140 (36%), Positives = 74/140 (52%), Gaps = 14/140 (10%)
Query: 105 GGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPH 164
GG PFWGG FIISGSLSVAAE ++ CL+ SLG NI+S + + G + + D + +
Sbjct: 14 GGVPFWGGACFIISGSLSVAAEKN-HTSCLVRSSLGTNILSVMAAFAGTAILLMDFGVTN 72
Query: 165 PYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNI 224
Y VL +F +LEF A + HFGCQ + Q+S + PN
Sbjct: 73 RDVDRGYL-------------AVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLPNA 119
Query: 225 YAANPVITPEPVTSPPSYSS 244
++A+ I ++PP+Y +
Sbjct: 120 FSADFNIPSPAASAPPAYDN 139
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 85.5 bits (210), Expect = 4e-17
Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 8/177 (4%)
Query: 67 KEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISGSLSVA 124
++ K LG ++I+I L + +G IM V Y I Y + WG + FIIS SLSVA
Sbjct: 65 RKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVA 124
Query: 125 AENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSI-PHPYAYPDYYPYAWGVNPGMA 183
A + + L+ GSLG NI S++ + G+++ L+ Y Y ++ + M+
Sbjct: 125 AGIRT-TKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMS 183
Query: 184 I----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPV 236
I G++L+ +LEF IA A S FGC+++CC S V +I P+ + +P P+
Sbjct: 184 ILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 84.3 bits (207), Expect = 9e-17
Identities = 58/177 (32%), Positives = 94/177 (53%), Gaps = 8/177 (4%)
Query: 67 KEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISGSLSVA 124
++ K LG ++I+I L + +G IM V Y I Y + WG + FIIS SLSVA
Sbjct: 65 RKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVA 124
Query: 125 AENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSI-PHPYAYPDYYPYAWGVNPGMA 183
A + + L+ GSLG NI S++ + G+++ L+ Y Y ++ + M+
Sbjct: 125 AGIRT-TKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMS 183
Query: 184 I----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPV 236
I G++L+ +LEF IA + S FGC+++CC S V +I P+ + +P P+
Sbjct: 184 ILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 84.3 bits (207), Expect = 9e-17
Identities = 58/177 (32%), Positives = 94/177 (53%), Gaps = 8/177 (4%)
Query: 67 KEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISGSLSVA 124
++ K LG ++I+I L + +G IM V Y I Y + WG + FIIS SLSVA
Sbjct: 65 RKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVA 124
Query: 125 AENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSI-PHPYAYPDYYPYAWGVNPGMA 183
A + + L+ GSLG NI S++ + G+++ L+ Y Y ++ + M+
Sbjct: 125 AGIRT-TKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMS 183
Query: 184 I----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPV 236
I G++L+ +LEF IA + S FGC+++CC S V +I P+ + +P P+
Sbjct: 184 ILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 71.2 bits (173), Expect = 8e-13
Identities = 41/107 (38%), Positives = 61/107 (57%), Gaps = 2/107 (1%)
Query: 54 VSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGL 113
+S++ G ++E KTLGA+QI+ GL HI LG ++ + G Y I +P WGG+
Sbjct: 34 MSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLL-MIPAGIYAPICVTVWYPLWGGI 92
Query: 114 WFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL 160
+IISGSL A E CL+ G + +N +S + G+IL I D+
Sbjct: 93 MYIISGSLLAATEKNSRK-CLVKGKMIMNSLSLFAAISGMILSIMDI 138
>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 71.2 bits (173), Expect = 8e-13
Identities = 41/107 (38%), Positives = 61/107 (57%), Gaps = 2/107 (1%)
Query: 54 VSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGL 113
+S++ G ++E KTLGA+QI+ GL HI LG ++ + G Y I +P WGG+
Sbjct: 34 MSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLL-MIPAGIYAPICVTVWYPLWGGI 92
Query: 114 WFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL 160
+IISGSL A E CL+ G + +N +S + G+IL I D+
Sbjct: 93 MYIISGSLLAATEKNSRK-CLVKGKMIMNSLSLFAAISGMILSIMDI 138
>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
isoform 2 [Homo sapiens]
Length = 195
Score = 66.6 bits (161), Expect = 2e-11
Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 16/142 (11%)
Query: 33 VPLYPNSQPQVHLVPGNPPS-----LVSNVNGQPVQKAL----KEGKTLGAIQIIIGLAH 83
+P P+S P ++ +P L+ + + P+ L KE + LG QI+ +
Sbjct: 13 LPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMIC 72
Query: 84 IGLGSIMATVL-----VGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGS 138
+ G+++ +VL G+ S SF G+PFWG ++F ISG LS+ +E + +Y L+ GS
Sbjct: 73 LCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISERRNATY-LVRGS 130
Query: 139 LGLNIVSAICSAVGVILFITDL 160
LG N S+I G+ + I +L
Sbjct: 131 LGANTASSIAGGTGITILIINL 152
>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
Length = 244
Score = 66.6 bits (161), Expect = 2e-11
Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 16/142 (11%)
Query: 33 VPLYPNSQPQVHLVPGNPPS-----LVSNVNGQPVQKAL----KEGKTLGAIQIIIGLAH 83
+P P+S P ++ +P L+ + + P+ L KE + LG QI+ +
Sbjct: 13 LPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMIC 72
Query: 84 IGLGSIMATVL-----VGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGS 138
+ G+++ +VL G+ S SF G+PFWG ++F ISG LS+ +E + +Y L+ GS
Sbjct: 73 LCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISERRNATY-LVRGS 130
Query: 139 LGLNIVSAICSAVGVILFITDL 160
LG N S+I G+ + I +L
Sbjct: 131 LGANTASSIAGGTGITILIINL 152
>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
[Homo sapiens]
Length = 267
Score = 66.6 bits (161), Expect = 2e-11
Identities = 60/227 (26%), Positives = 100/227 (44%), Gaps = 20/227 (8%)
Query: 29 IMSHVPLYPNSQPQVHLVPGNPPSLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGS 88
++S V + S PQ P L++ + QK K LGA I I L H+ G
Sbjct: 21 VLSPVQPWQTSAPQ----NTTQPKLLAPHQHEKSQKKSSLLKELGAFHITIALLHLVFGG 76
Query: 89 IMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSY----CLLSGSLGLNIV 144
+A+++ +L + +PFWG F+ISG L++ + +Y CL++ N++
Sbjct: 77 YLASIVKNLHLVV-LKSWYPFWGAASFLISGILAITMKTFSKTYLKMLCLMT-----NLI 130
Query: 145 SAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSH 204
S C G+ + DL + P+ P + Y + LL F +LE + ++
Sbjct: 131 SLFCVLSGLFVISKDLFLESPFESPIWRMYPNSTVHIQRLELALLCFTVLELFLPVPTAV 190
Query: 205 FGCQLVCCQSSN-VSVIYPNIYAANPV-ITPEPVTSPPSYSSEIQAN 249
+ C + N + + PN P+ + PV PPSY S IQ +
Sbjct: 191 TAWRGDCPSAKNDDACLVPN----TPLHLKGLPVEPPPSYQSVIQGD 233
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 65.9 bits (159), Expect = 3e-11
Identities = 50/185 (27%), Positives = 82/185 (44%), Gaps = 17/185 (9%)
Query: 52 SLVSNVNGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATV-----LVGEYLSISFYGG 106
S+ ++G P + K + LGAIQI+ + LG + ++ + +FY G
Sbjct: 32 SVYQPIDGSPDYQKAKL-QVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTG 90
Query: 107 FPFWGGLWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSI---- 162
+P WG ++F SG+LSV A +P + + S G+NI SA + VG ++++
Sbjct: 91 YPIWGAVFFCSSGTLSVVAGIKP-TRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQS 149
Query: 163 ----PHPYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVS 218
PD Y ++ GM +LL+ LLE + ++ C CC S
Sbjct: 150 LRSCHSSSESPDLCNYMGSISNGMV--SLLLILTLLELCVTISTIAMWCNANCCNSREEI 207
Query: 219 VIYPN 223
PN
Sbjct: 208 SSPPN 212
>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
isoform 1 [Homo sapiens]
Length = 679
Score = 57.8 bits (138), Expect = 9e-09
Identities = 36/103 (34%), Positives = 56/103 (54%), Gaps = 7/103 (6%)
Query: 68 EGKTLGAIQIIIGLAHIGLGSIMATVLVG--EYLSISFYGGFPFWGGLWFIISGSLSVAA 125
E + LGA QI++ L +G G+I A +G + L + G+PFWG L FI++G L+V
Sbjct: 41 EPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGALIFILTGYLTVTD 100
Query: 126 ENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAY 168
+ S L G G+N++S++ + G+ T LS H Y
Sbjct: 101 KK---SKLLGQGVTGMNVISSLVAITGIT--FTILSYRHQDKY 138
>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
[Homo sapiens]
Length = 200
Score = 57.0 bits (136), Expect = 2e-08
Identities = 46/159 (28%), Positives = 75/159 (47%), Gaps = 9/159 (5%)
Query: 61 PVQKAL-KEGKTLGAIQIIIGLAHIGLGSIMATVLVGEY--LSISFYGGFPFWGGLWFII 117
P+QK ++ K LG IQI+ G+ G I L+ Y F G+PFWG + FI
Sbjct: 38 PLQKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRFPFIFLSGYPFWGSVLFIN 97
Query: 118 SGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVIL----FITDLSIPHPYAYPDYYP 173
SG+ +A + + ++ + +N +SA+ + G+IL FI D + Y++ +
Sbjct: 98 SGAFLIAVKRKTTETLIILSRI-MNFLSALGAIAGIILLTFGFILDQNYICGYSHQNSQC 156
Query: 174 YAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCC 212
A V + I L+ F ++E I+ S GC C
Sbjct: 157 KAVTV-LFLGILITLMTFSIIELFISLPFSILGCHSEDC 194
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 51.2 bits (121), Expect = 8e-07
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 5/92 (5%)
Query: 68 EGKTLGAIQIIIGLAHIGLGSIMATVLVG----EYLSISFYGGFPFWGGLWFIISGSLSV 123
E K +G IQI+ G+ + LG I+A+ + S +PF G +FIISGSLS+
Sbjct: 44 EIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSI 103
Query: 124 AAENQPYSYCLLSGSLGLNIVSAICSAVGVIL 155
A E + + L+ SL +I+SA+ + VG I+
Sbjct: 104 ATEKR-LTKLLVHSSLVGSILSALSALVGFII 134
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 51.2 bits (121), Expect = 8e-07
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 5/92 (5%)
Query: 68 EGKTLGAIQIIIGLAHIGLGSIMATVLVG----EYLSISFYGGFPFWGGLWFIISGSLSV 123
E K +G IQI+ G+ + LG I+A+ + S +PF G +FIISGSLS+
Sbjct: 44 EIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSI 103
Query: 124 AAENQPYSYCLLSGSLGLNIVSAICSAVGVIL 155
A E + + L+ SL +I+SA+ + VG I+
Sbjct: 104 ATEKR-LTKLLVHSSLVGSILSALSALVGFII 134
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 51.2 bits (121), Expect = 8e-07
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 5/92 (5%)
Query: 68 EGKTLGAIQIIIGLAHIGLGSIMATVLVG----EYLSISFYGGFPFWGGLWFIISGSLSV 123
E K +G IQI+ G+ + LG I+A+ + S +PF G +FIISGSLS+
Sbjct: 44 EIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSI 103
Query: 124 AAENQPYSYCLLSGSLGLNIVSAICSAVGVIL 155
A E + + L+ SL +I+SA+ + VG I+
Sbjct: 104 ATEKR-LTKLLVHSSLVGSILSALSALVGFII 134
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 47.8 bits (112), Expect = 9e-06
Identities = 48/173 (27%), Positives = 76/173 (43%), Gaps = 31/173 (17%)
Query: 58 NGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEY----LSISFYGGFPFWGGL 113
NG P + + LG +QI+ L LG+I+ + +S + G+PF G L
Sbjct: 39 NGLPTETTV-----LGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGAL 93
Query: 114 WFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL------------- 160
F I+GSLS+ + Q LS SL N VS++ + G+ L +
Sbjct: 94 CFGITGSLSIISGKQSTKPFDLS-SLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSE 152
Query: 161 -----SIPHPYAYPDYYPYAWGVNPGMAISGVL---LVFCLLEFGIACASSHF 205
S+P+ Y Y + ++++GVL L+F +LE +A SS F
Sbjct: 153 MDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 205
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 47.8 bits (112), Expect = 9e-06
Identities = 48/173 (27%), Positives = 76/173 (43%), Gaps = 31/173 (17%)
Query: 58 NGQPVQKALKEGKTLGAIQIIIGLAHIGLGSIMATVLVGEY----LSISFYGGFPFWGGL 113
NG P + + LG +QI+ L LG+I+ + +S + G+PF G L
Sbjct: 39 NGLPTETTV-----LGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGAL 93
Query: 114 WFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL------------- 160
F I+GSLS+ + Q LS SL N VS++ + G+ L +
Sbjct: 94 CFGITGSLSIISGKQSTKPFDLS-SLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSE 152
Query: 161 -----SIPHPYAYPDYYPYAWGVNPGMAISGVL---LVFCLLEFGIACASSHF 205
S+P+ Y Y + ++++GVL L+F +LE +A SS F
Sbjct: 153 MDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 205
>gi|155029533 membrane-spanning 4-domains, subfamily A, member 13
isoform 1 [Homo sapiens]
Length = 152
Score = 47.4 bits (111), Expect = 1e-05
Identities = 38/137 (27%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 78 IIGLAHIGLGSIMATVLVGE-------YLSISFYGGFPFWGGLWFIISGSLSVAAENQPY 130
+IG+ HI + + + +G+ Y +++ G WG ++FII+G + P
Sbjct: 1 MIGIFHIFMWYFLLVLYMGQIKGAFGTYEPVTYKTGCTLWG-IFFIIAGVFLIRVTKYPT 59
Query: 131 SYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAYPDYYPYAWGVNPGMAISGVLLV 190
++S +L +NI+ I + V L I +LS + +Y +Y G +S +LL
Sbjct: 60 RSGIIS-TLIINIICIITTITAVTLTIIELSHFNSVSYRNYGQ----AKLGREVSRILLF 114
Query: 191 FCLLEFGIACASSHFGC 207
F LEF IA S + C
Sbjct: 115 FYGLEFSIALTHSIYSC 131
>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
isoform 2 [Homo sapiens]
Length = 662
Score = 41.6 bits (96), Expect = 7e-04
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 24/103 (23%)
Query: 68 EGKTLGAIQIIIGLAHIGLGSIMATVLVG--EYLSISFYGGFPFWGGLWFIISGSLSVAA 125
E + LGA QI++ L +G G+I A +G + L + G+PFWG L
Sbjct: 41 EPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGAL------------ 88
Query: 126 ENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIPHPYAY 168
+ G G+N++S++ + G+ T LS H Y
Sbjct: 89 --------IGQGVTGMNVISSLVAITGIT--FTILSYRHQDKY 121
>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
isoform b [Homo sapiens]
Length = 168
Score = 40.4 bits (93), Expect = 0.001
Identities = 33/119 (27%), Positives = 50/119 (42%), Gaps = 11/119 (9%)
Query: 113 LWFIISGSLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSIP--------H 164
L F SG+LSV A +P + + S G+NI SA + VG ++++
Sbjct: 51 LGFCSSGTLSVVAGIKP-TRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHS 109
Query: 165 PYAYPDYYPYAWGVNPGMAISGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPN 223
PD Y ++ GM +LL+ LLE + ++ C CC S PN
Sbjct: 110 SSESPDLCNYMGSISNGMV--SLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPN 166
>gi|38146116 hypothetical protein LOC10712 isoform a [Homo sapiens]
Length = 668
Score = 34.7 bits (78), Expect = 0.080
Identities = 20/85 (23%), Positives = 42/85 (49%), Gaps = 5/85 (5%)
Query: 71 TLGAIQIIIGLAHIGLGSIMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPY 130
TLG +Q+++G+ + + ++V E + S P W G SG + + + +P+
Sbjct: 36 TLGLVQVLLGILVVTFSMVASSVTTTESIKRS----CPSWAGFSLAFSGVVGIVSWKRPF 91
Query: 131 SYCLLSGSLGLNIVSAICSAVGVIL 155
+ + SL L+++ + S G +L
Sbjct: 92 TLVISFFSL-LSVLCVMLSMAGSVL 115
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 32.3 bits (72), Expect = 0.40
Identities = 28/86 (32%), Positives = 39/86 (45%), Gaps = 18/86 (20%)
Query: 78 IIGLAHIGLG------SIMATVLVGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYS 131
I+G A IGLG S M T + G S GF GG +++IS SL
Sbjct: 203 IVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPE------- 255
Query: 132 YCLLSGSLGLNIVSAICSAVGVILFI 157
GS+GL + A +AV V +++
Sbjct: 256 ---FGGSIGL--IFAFANAVAVAMYV 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,362,266
Number of Sequences: 37866
Number of extensions: 483264
Number of successful extensions: 1642
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 1496
Number of HSP's gapped (non-prelim): 132
length of query: 250
length of database: 18,247,518
effective HSP length: 100
effective length of query: 150
effective length of database: 14,460,918
effective search space: 2169137700
effective search space used: 2169137700
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.