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Search of human proteins with 13677220
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13677220 receptor-type protein tyrosine phosphatase O
isoform d precursor [Homo sapiens]
(377 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 773 0.0
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 773 0.0
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 773 0.0
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 758 0.0
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 758 0.0
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 758 0.0
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 303 2e-82
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 303 2e-82
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 286 2e-77
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 279 3e-75
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 266 2e-71
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 266 2e-71
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 228 9e-60
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 228 9e-60
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 225 4e-59
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 225 4e-59
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 225 4e-59
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 225 4e-59
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 224 1e-58
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 223 2e-58
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 223 2e-58
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 223 2e-58
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 223 2e-58
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 222 4e-58
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 222 4e-58
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 220 2e-57
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 220 2e-57
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 220 2e-57
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 219 3e-57
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 219 3e-57
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 773 bits (1995), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
Query: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
Query: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
Query: 361 KQQFCISDVIYENVSKS 377
KQQFCISDVIYENVSKS
Sbjct: 361 KQQFCISDVIYENVSKS 377
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 773 bits (1995), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
Query: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
Query: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
Query: 361 KQQFCISDVIYENVSKS 377
KQQFCISDVIYENVSKS
Sbjct: 361 KQQFCISDVIYENVSKS 377
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 773 bits (1995), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 812 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871
Query: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 872 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
Query: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 1052 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 1111
Query: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 1112 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 1171
Query: 361 KQQFCISDVIYENVSKS 377
KQQFCISDVIYENVSKS
Sbjct: 1172 KQQFCISDVIYENVSKS 1188
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 758 bits (1956), Expect = 0.0
Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)
Query: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 61 LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 92
LPYNW SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 61 LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 120
Query: 93 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 152
KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 121 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 180
Query: 153 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 212
YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 181 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 240
Query: 213 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 272
PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 241 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 300
Query: 273 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 332
ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 301 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 360
Query: 333 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 377
RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 361 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 405
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 758 bits (1956), Expect = 0.0
Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)
Query: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 61 LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 92
LPYNW SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 61 LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 120
Query: 93 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 152
KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 121 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 180
Query: 153 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 212
YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 181 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 240
Query: 213 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 272
PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 241 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 300
Query: 273 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 332
ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 301 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 360
Query: 333 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 377
RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 361 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 405
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 758 bits (1956), Expect = 0.0
Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)
Query: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 812 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871
Query: 61 LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 92
LPYNW SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 872 LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 931
Query: 93 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 152
KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 932 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 991
Query: 153 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 212
YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 992 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1051
Query: 213 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 272
PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 1052 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 1111
Query: 273 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 332
ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 1112 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 1171
Query: 333 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 377
RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 1172 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 1216
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 303 bits (776), Expect = 2e-82
Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)
Query: 22 LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
LIG+L+ V L+I R+K + RE + S+ RD L + + RK + P+
Sbjct: 1847 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1901
Query: 80 QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
+++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +R
Sbjct: 1902 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1961
Query: 140 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
V+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQ
Sbjct: 1962 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 2021
Query: 200 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
C EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF
Sbjct: 2022 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 2081
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
+YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 2082 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 2139
Query: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
Q + + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IY
Sbjct: 2140 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 2199
Query: 372 ENVS 375
ENV+
Sbjct: 2200 ENVN 2203
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 303 bits (776), Expect = 2e-82
Identities = 165/364 (45%), Positives = 234/364 (64%), Gaps = 17/364 (4%)
Query: 22 LIGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPV 79
LIG+L+ V L+I R+K + RE + S+ RD L + + RK + P+
Sbjct: 1629 LIGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPI 1683
Query: 80 QLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 139
+++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +R
Sbjct: 1684 KINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATR 1743
Query: 140 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 199
V+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQ
Sbjct: 1744 VKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQ 1803
Query: 200 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHF 256
C EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF
Sbjct: 1804 CVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHF 1863
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLL 314
+YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+L
Sbjct: 1864 HYTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRIL 1921
Query: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIY 371
Q + + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IY
Sbjct: 1922 QQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIY 1981
Query: 372 ENVS 375
ENV+
Sbjct: 1982 ENVN 1985
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 286 bits (732), Expect = 2e-77
Identities = 156/388 (40%), Positives = 222/388 (57%), Gaps = 20/388 (5%)
Query: 2 VTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQ-----------MARECGAGTFV 50
++E +++ L ILS +L+G + +R+K + + + +
Sbjct: 1899 LSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI 1958
Query: 51 NFASLE-RDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 109
A LE +D +L L RK P+ F +++++ +++ KF +F EL
Sbjct: 1959 TVADLELKDERLT-----RLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKF 2013
Query: 110 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 169
D+ ADLP NR KNR+ NI PY+ +RV+L++ G+DYINA+YI GY P E+I
Sbjct: 2014 LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFI 2073
Query: 170 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEM 228
ATQGPLP T DFW+MV + +++ +VMLTQC EK R++C YWP +P+ +GDI +
Sbjct: 2074 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITK 2133
Query: 229 ISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATK 288
+ E+ Q DW R +I + V N+TAWP+HGVP +A ++ FV +VR
Sbjct: 2134 LMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAH 2191
Query: 289 SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIF 348
PMI+HCSAGVGRTG FIALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF
Sbjct: 2192 DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIF 2251
Query: 349 IHQCVQLMWMKKKQQFCISDVIYENVSK 376
+HQC+ + K I V Y + K
Sbjct: 2252 LHQCILDLLSNKGSNQPICFVNYSALQK 2279
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 279 bits (714), Expect = 3e-75
Identities = 145/334 (43%), Positives = 220/334 (65%), Gaps = 14/334 (4%)
Query: 47 GTFVNFASLERDGKL-PYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEE 105
G F+ + +D K ++S+ KK KL +++++F+AY K DS+ F+ ++E+
Sbjct: 991 GGFIFWRKKRKDAKNNEVSFSQIKPKKSKL---IRVENFEAYFKKQQADSNCGFAEEYED 1047
Query: 106 LKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSP 165
LKL+G+ P +AA+L NR KNRY N+LPYD SRV+L S+ DYINANY+PGY+S
Sbjct: 1048 LKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL-SVQTHSTDDYINANYMPGYHSK 1106
Query: 166 QEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDIT 225
+++IATQGPLP T DFW+MV ++ I+MLT+C E+ R KC+ YWP +++ YGDIT
Sbjct: 1107 KDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP-SKQAQDYGDIT 1165
Query: 226 VEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVR 283
V M SE +W R F + E + F++T+WPDHGVP + + ++ F ++VR
Sbjct: 1166 VAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP--DTTDLLINFRYLVR 1223
Query: 284 QQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQ 341
+S + P+++HCSAGVGRTGTFIA+DRL+ I + VD+ G+V ++R +R MVQ
Sbjct: 1224 DYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQ 1283
Query: 342 TEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 375
TE+QY+F++QCV + + + Q+ D+IY+N +
Sbjct: 1284 TEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform
2 precursor [Homo sapiens]
Length = 937
Score = 266 bits (681), Expect = 2e-71
Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)
Query: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
+ +DF +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+S
Sbjct: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
RV L ++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT
Sbjct: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
C E RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F
Sbjct: 742 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 801
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
+Y AWPDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL
Sbjct: 802 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 859
Query: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
+ ++ + V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 860 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 266 bits (681), Expect = 2e-71
Identities = 131/300 (43%), Positives = 189/300 (63%), Gaps = 6/300 (2%)
Query: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
+ +DF +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+S
Sbjct: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
RV L ++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT
Sbjct: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHF 256
C E RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F
Sbjct: 920 NCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQF 979
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLL 314
+Y AWPDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL
Sbjct: 980 HYQAWPDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLL 1037
Query: 315 QHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 374
+ ++ + V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 1038 RQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 228 bits (580), Expect = 9e-60
Identities = 129/344 (37%), Positives = 193/344 (56%), Gaps = 14/344 (4%)
Query: 17 ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPY-----NWSKNGLK 71
+L+ +LI L+++ +++ ++K + SL P N+ G++
Sbjct: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
Query: 72 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
P+ + D I+ + + KFS ++E + G ++L +N+ KNRY N
Sbjct: 1328 DHP---PIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYAN 1383
Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
++ YD SRV L S++ G+DYINANYI GY YIATQGPLPET DFW+MV +Q++
Sbjct: 1384 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT 1443
Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADE 249
+VM+T+ EK RVKCD YWP G I V ++ E + R F ++ + E
Sbjct: 1444 ATVVMMTRLEEKSRVKCDQYWP-ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSE 1502
Query: 250 MQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA 309
+++ F + AWPDHGVP IL F+ V+ GPM++HCSAGVGRTG FI
Sbjct: 1503 KRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560
Query: 310 LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
+D +L+ ++ + VDI G V+ MRS R MVQTE+QY+FIH+ +
Sbjct: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
Score = 188 bits (477), Expect = 8e-48
Identities = 103/251 (41%), Positives = 145/251 (57%), Gaps = 13/251 (5%)
Query: 105 ELKLIGLDIPH----FAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP 160
E KL+ H +A+LP N+ KNR NI+PY+ +RV L + EG+DYINA+++
Sbjct: 1642 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD 1701
Query: 161 GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIA 220
GY + YIATQGPL E+ DFW+M+ + S IIVMLT+ E R KC YWP E
Sbjct: 1702 GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSAR 1760
Query: 221 YGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF 278
Y V+ ++E + R F++ A + Q + F +T WP+ GVP E + F
Sbjct: 1761 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDF 1818
Query: 279 ---VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSY 335
VH ++Q + GP+ +HCSAGVGRTG FI L +L+ +R VD+ V +R+
Sbjct: 1819 IGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQ 1877
Query: 336 RMSMVQTEEQY 346
R +MVQTE+QY
Sbjct: 1878 RPAMVQTEDQY 1888
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 228 bits (580), Expect = 9e-60
Identities = 129/344 (37%), Positives = 193/344 (56%), Gaps = 14/344 (4%)
Query: 17 ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPY-----NWSKNGLK 71
+L+ +LI L+++ +++ ++K + SL P N+ G++
Sbjct: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
Query: 72 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
P+ + D I+ + + KFS ++E + G ++L +N+ KNRY N
Sbjct: 1319 DHP---PIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYAN 1374
Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
++ YD SRV L S++ G+DYINANYI GY YIATQGPLPET DFW+MV +Q++
Sbjct: 1375 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT 1434
Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADE 249
+VM+T+ EK RVKCD YWP G I V ++ E + R F ++ + E
Sbjct: 1435 ATVVMMTRLEEKSRVKCDQYWP-ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSE 1493
Query: 250 MQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA 309
+++ F + AWPDHGVP IL F+ V+ GPM++HCSAGVGRTG FI
Sbjct: 1494 KRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1551
Query: 310 LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
+D +L+ ++ + VDI G V+ MRS R MVQTE+QY+FIH+ +
Sbjct: 1552 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
Score = 188 bits (477), Expect = 8e-48
Identities = 103/251 (41%), Positives = 145/251 (57%), Gaps = 13/251 (5%)
Query: 105 ELKLIGLDIPH----FAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP 160
E KL+ H +A+LP N+ KNR NI+PY+ +RV L + EG+DYINA+++
Sbjct: 1633 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD 1692
Query: 161 GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIA 220
GY + YIATQGPL E+ DFW+M+ + S IIVMLT+ E R KC YWP E
Sbjct: 1693 GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSAR 1751
Query: 221 YGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF 278
Y V+ ++E + R F++ A + Q + F +T WP+ GVP E + F
Sbjct: 1752 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDF 1809
Query: 279 ---VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSY 335
VH ++Q + GP+ +HCSAGVGRTG FI L +L+ +R VD+ V +R+
Sbjct: 1810 IGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQ 1868
Query: 336 RMSMVQTEEQY 346
R +MVQTE+QY
Sbjct: 1869 RPAMVQTEDQY 1879
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 225 bits (574), Expect = 4e-59
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 10 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 1270 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1318
Query: 70 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1377
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 1378 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1437
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1438 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1496
Query: 241 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1497 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1554
Query: 299 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1555 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1609
Score = 191 bits (484), Expect = 1e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1663 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1722
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1723 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1781
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1782 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1838
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1839 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1898
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 225 bits (574), Expect = 4e-59
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 10 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 1257 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1305
Query: 70 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1364
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 1365 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1424
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1425 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1483
Query: 241 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1484 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1541
Query: 299 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1542 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1596
Score = 191 bits (484), Expect = 1e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1650 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1709
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1710 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1768
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1769 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1825
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1826 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1885
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 225 bits (574), Expect = 4e-59
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 10 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 1261 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1309
Query: 70 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1368
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 1369 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1428
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1429 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1487
Query: 241 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1488 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1545
Query: 299 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1546 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1600
Score = 191 bits (484), Expect = 1e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1654 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1713
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1714 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1772
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1773 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1829
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 225 bits (574), Expect = 4e-59
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 10 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 69
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 859 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 907
Query: 70 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 908 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 966
Query: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 967 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1026
Query: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1027 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1085
Query: 241 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 298
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1086 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1143
Query: 299 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1144 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1198
Score = 191 bits (484), Expect = 1e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1312 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1370
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1427
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1487
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 224 bits (571), Expect = 1e-58
Identities = 124/348 (35%), Positives = 199/348 (57%), Gaps = 19/348 (5%)
Query: 17 ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLT 76
+L+ + I +++ +++ + K + E + +S+ + ++P + + ++ R+L
Sbjct: 860 VLAVVFIICIVIAILLYKSKPDRKRAESDSRK----SSIPNNKEIPSHHPTDPVELRRLN 915
Query: 77 ---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKN 127
P+ + + +I+ + + + KFS ++E + G ++L +N+ KN
Sbjct: 916 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKN 974
Query: 128 RYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVL 187
RY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET DFW+M+
Sbjct: 975 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1034
Query: 188 QQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--N 245
+Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R F + N
Sbjct: 1035 EQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1093
Query: 246 YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTG 305
+ E ++V F +TAWPDHGVP L F+ V+ GPM++HCSAGVGRTG
Sbjct: 1094 GSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1151
Query: 306 TFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1152 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199
Score = 191 bits (484), Expect = 1e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1253 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1312
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1313 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1371
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1372 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1428
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1429 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1488
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 223 bits (569), Expect = 2e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 78 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 929 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 987
Query: 138 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 988 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1047
Query: 198 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1048 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1106
Query: 256 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1107 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1164
Query: 316 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1165 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202
Score = 191 bits (486), Expect = 7e-49
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1256 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1374
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1375 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1431
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1432 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1491
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 223 bits (569), Expect = 2e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 78 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 1334 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 1392
Query: 138 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 1393 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1452
Query: 198 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1453 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511
Query: 256 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1512 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1569
Query: 316 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1570 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607
Score = 191 bits (486), Expect = 7e-49
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1779
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1780 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1836
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1837 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1896
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 223 bits (569), Expect = 2e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 78 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 925 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 983
Query: 138 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 984 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1043
Query: 198 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1044 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1102
Query: 256 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1103 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1160
Query: 316 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1161 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198
Score = 191 bits (486), Expect = 7e-49
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1370
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1427
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1487
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 223 bits (569), Expect = 2e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 78 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 137
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 1430
Query: 138 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 197
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
Query: 198 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 255
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1491 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1549
Query: 256 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 315
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1550 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607
Query: 316 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1645
Score = 191 bits (486), Expect = 7e-49
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 117 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 176
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1699 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1758
Query: 177 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 236
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1759 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1817
Query: 237 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 291
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1818 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1874
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1875 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1934
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 222 bits (566), Expect = 4e-58
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 7/277 (2%)
Query: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
+++ D +I M + Y F ++E L G A NR KNRY NI+ YD S
Sbjct: 869 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 927
Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
RVRL+ ++ + +DYINANYI GY+ P+ YIATQGP+ ET DFW+M+ Q+ S IVM+T
Sbjct: 928 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987
Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHF 256
E RVKC YWP ++ YGDI V +I E ++ R F + E++++ F
Sbjct: 988 NLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1045
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
++T+WPDHGVP A +L FV V+ GP+++HCSAG GRTG FIA+D +L
Sbjct: 1046 HFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1103
Query: 317 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
+ VDI V E+R+ R+++VQTEEQY+F+H +
Sbjct: 1104 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
Score = 128 bits (321), Expect = 1e-29
Identities = 78/239 (32%), Positives = 125/239 (52%), Gaps = 12/239 (5%)
Query: 120 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
LP N KNR ++LP D L+S+ + E ++YINA + + P ++ TQ PLP T
Sbjct: 1199 LPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1257
Query: 180 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAC 239
DFW++V +VML + + + C YWP + YG I VE +S + +D
Sbjct: 1258 ADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWP-EKTSGCYGPIQVEFVSADIDEDIIH 1314
Query: 240 RHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKGP 292
R FRI QD V H Y WP + T + S+L+ V + ++Q +G
Sbjct: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYR-DTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
Query: 293 MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
++HC G GR+GTF A+ + + I+ +D+ +V +R+ + +MV+T EQY F+++
Sbjct: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE 1432
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 222 bits (566), Expect = 4e-58
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 7/277 (2%)
Query: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
+++ D +I M + Y F ++E L G A NR KNRY NI+ YD S
Sbjct: 888 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 946
Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
RVRL+ ++ + +DYINANYI GY+ P+ YIATQGP+ ET DFW+M+ Q+ S IVM+T
Sbjct: 947 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006
Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHF 256
E RVKC YWP ++ YGDI V +I E ++ R F + E++++ F
Sbjct: 1007 NLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
++T+WPDHGVP A +L FV V+ GP+++HCSAG GRTG FIA+D +L
Sbjct: 1065 HFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1122
Query: 317 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
+ VDI V E+R+ R+++VQTEEQY+F+H +
Sbjct: 1123 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Score = 128 bits (321), Expect = 1e-29
Identities = 78/239 (32%), Positives = 125/239 (52%), Gaps = 12/239 (5%)
Query: 120 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
LP N KNR ++LP D L+S+ + E ++YINA + + P ++ TQ PLP T
Sbjct: 1218 LPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1276
Query: 180 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAC 239
DFW++V +VML + + + C YWP + YG I VE +S + +D
Sbjct: 1277 ADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWP-EKTSGCYGPIQVEFVSADIDEDIIH 1333
Query: 240 RHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKGP 292
R FRI QD V H Y WP + T + S+L+ V + ++Q +G
Sbjct: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYR-DTPPSKRSLLKVVRRLEKWQEQYDGREGR 1392
Query: 293 MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
++HC G GR+GTF A+ + + I+ +D+ +V +R+ + +MV+T EQY F+++
Sbjct: 1393 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE 1451
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform
3 precursor [Homo sapiens]
Length = 1256
Score = 220 bits (560), Expect = 2e-57
Identities = 125/346 (36%), Positives = 188/346 (54%), Gaps = 19/346 (5%)
Query: 13 SVLAILSTLLIGLLLVTLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLK 71
+++A L+ L+I + L++L K + L R C +ERD + K
Sbjct: 528 ALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------K 575
Query: 72 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
+ P+ D K D F +F+ + + P A P N+ KNRY +
Sbjct: 576 QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVD 635
Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
ILPYD++RV L +N + G++YINA+YI G+ P++YIA QGP ET +DFW+M+ +QK+
Sbjct: 636 ILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA 695
Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM 250
+IVM+T+C E R KC YWP EE A+GD+ V++ + D+ + I E
Sbjct: 696 TVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 755
Query: 251 ---QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTF 307
++V H +T+WPDHGVP +L+ V + GP+++HCSAGVGRTGT+
Sbjct: 756 ATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY 813
Query: 308 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I +D +L+ + VD+ G V ++R R MVQ E QYI IHQ +
Sbjct: 814 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Score = 140 bits (354), Expect = 1e-33
Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)
Query: 123 NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 163
N+ KNR +N++PYD++RV L + EE + YINA++I Y
Sbjct: 918 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 977
Query: 164 SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 223
P+ IA QGPL ET DFW+M+ Q+K ++IVMLT+ + C YW E YGD
Sbjct: 978 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 1035
Query: 224 ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 280
I V++ ++ + R F + ++ + + V + YT W +P S++Q V
Sbjct: 1036 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 1095
Query: 281 MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 333
Q S+G P++IHC G +TG F AL LL+ E VDI +V +R
Sbjct: 1096 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1155
Query: 334 SYRMSMVQTEEQYIFIHQCV 353
R MV T EQY F++ +
Sbjct: 1156 KARPGMVSTFEQYQFLYDVI 1175
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform
1 precursor [Homo sapiens]
Length = 1304
Score = 220 bits (560), Expect = 2e-57
Identities = 125/346 (36%), Positives = 188/346 (54%), Gaps = 19/346 (5%)
Query: 13 SVLAILSTLLIGLLLVTLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLK 71
+++A L+ L+I + L++L K + L R C +ERD + K
Sbjct: 576 ALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------K 623
Query: 72 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
+ P+ D K D F +F+ + + P A P N+ KNRY +
Sbjct: 624 QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVD 683
Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
ILPYD++RV L +N + G++YINA+YI G+ P++YIA QGP ET +DFW+M+ +QK+
Sbjct: 684 ILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA 743
Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM 250
+IVM+T+C E R KC YWP EE A+GD+ V++ + D+ + I E
Sbjct: 744 TVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 803
Query: 251 ---QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTF 307
++V H +T+WPDHGVP +L+ V + GP+++HCSAGVGRTGT+
Sbjct: 804 ATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY 861
Query: 308 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I +D +L+ + VD+ G V ++R R MVQ E QYI IHQ +
Sbjct: 862 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Score = 140 bits (354), Expect = 1e-33
Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)
Query: 123 NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 163
N+ KNR +N++PYD++RV L + EE + YINA++I Y
Sbjct: 966 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 1025
Query: 164 SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 223
P+ IA QGPL ET DFW+M+ Q+K ++IVMLT+ + C YW E YGD
Sbjct: 1026 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 1083
Query: 224 ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 280
I V++ ++ + R F + ++ + + V + YT W +P S++Q V
Sbjct: 1084 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 1143
Query: 281 MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 333
Q S+G P++IHC G +TG F AL LL+ E VDI +V +R
Sbjct: 1144 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1203
Query: 334 SYRMSMVQTEEQYIFIHQCV 353
R MV T EQY F++ +
Sbjct: 1204 KARPGMVSTFEQYQFLYDVI 1223
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform
2 precursor [Homo sapiens]
Length = 1143
Score = 220 bits (560), Expect = 2e-57
Identities = 125/346 (36%), Positives = 188/346 (54%), Gaps = 19/346 (5%)
Query: 13 SVLAILSTLLIGLLLVTLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLK 71
+++A L+ L+I + L++L K + L R C +ERD + K
Sbjct: 415 ALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------K 462
Query: 72 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 131
+ P+ D K D F +F+ + + P A P N+ KNRY +
Sbjct: 463 QLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVD 522
Query: 132 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 191
ILPYD++RV L +N + G++YINA+YI G+ P++YIA QGP ET +DFW+M+ +QK+
Sbjct: 523 ILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKA 582
Query: 192 QIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM 250
+IVM+T+C E R KC YWP EE A+GD+ V++ + D+ + I E
Sbjct: 583 TVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEK 642
Query: 251 ---QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTF 307
++V H +T+WPDHGVP +L+ V + GP+++HCSAGVGRTGT+
Sbjct: 643 ATGREVTHIQFTSWPDHGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY 700
Query: 308 IALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
I +D +L+ + VD+ G V ++R R MVQ E QYI IHQ +
Sbjct: 701 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Score = 140 bits (354), Expect = 1e-33
Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)
Query: 123 NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 163
N+ KNR +N++PYD++RV L + EE + YINA++I Y
Sbjct: 805 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 864
Query: 164 SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 223
P+ IA QGPL ET DFW+M+ Q+K ++IVMLT+ + C YW E YGD
Sbjct: 865 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 922
Query: 224 ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 280
I V++ ++ + R F + ++ + + V + YT W +P S++Q V
Sbjct: 923 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 982
Query: 281 MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 333
Q S+G P++IHC G +TG F AL LL+ E VDI +V +R
Sbjct: 983 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1042
Query: 334 SYRMSMVQTEEQYIFIHQCV 353
R MV T EQY F++ +
Sbjct: 1043 KARPGMVSTFEQYQFLYDVI 1062
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 219 bits (558), Expect = 3e-57
Identities = 117/277 (42%), Positives = 162/277 (58%), Gaps = 7/277 (2%)
Query: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
+++ D +I M Y F ++E G P +A NR KNRY NI+ YD S
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
RVRL ++ + +DYIN NYI GY+ P YIATQGP+ ET DFW+MV + + I+M+T
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHF 256
E RVKC YWP ++ Y DI V +I E ++ R F + E++++ F
Sbjct: 999 NLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1056
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
++T WPDHGVP A +L FV V+ ++ S GP+++HCSAG GRTG FI +D +L
Sbjct: 1057 HFTGWPDHGVP--YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114
Query: 317 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
VDI V E+RS R++MVQTEEQY+FIH +
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151
Score = 122 bits (306), Expect = 5e-28
Identities = 79/240 (32%), Positives = 123/240 (51%), Gaps = 14/240 (5%)
Query: 120 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
LP N KNR +ILP D L+++ + E ++YINA + Y P +I TQ PLP T
Sbjct: 1210 LPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTV 1268
Query: 180 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWA 238
DFW++VL +VML + + C YWP E + +G I VE +S + ++D
Sbjct: 1269 KDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWP--ENGVHRHGPIQVEFVSADLEEDII 1324
Query: 239 CRHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKG 291
R FRI A QD V F + WP + T + S L+ + V +++ +G
Sbjct: 1325 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYR-DTPVSKRSFLKLIRQVDKWQEEYNGGEG 1383
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
++HC G GR+GTF A+ + + +R VD+ V +R+ + +MV +QY F ++
Sbjct: 1384 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE 1443
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 219 bits (558), Expect = 3e-57
Identities = 117/277 (42%), Positives = 162/277 (58%), Gaps = 7/277 (2%)
Query: 79 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 138
+++ D +I M Y F ++E G P +A NR KNRY NI+ YD S
Sbjct: 893 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 951
Query: 139 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 198
RVRL ++ + +DYIN NYI GY+ P YIATQGP+ ET DFW+MV + + I+M+T
Sbjct: 952 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011
Query: 199 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHF 256
E RVKC YWP ++ Y DI V +I E ++ R F + E++++ F
Sbjct: 1012 NLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1069
Query: 257 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 316
++T WPDHGVP A +L FV V+ ++ S GP+++HCSAG GRTG FI +D +L
Sbjct: 1070 HFTGWPDHGVP--YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1127
Query: 317 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
VDI V E+RS R++MVQTEEQY+FIH +
Sbjct: 1128 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164
Score = 122 bits (306), Expect = 5e-28
Identities = 79/240 (32%), Positives = 123/240 (51%), Gaps = 14/240 (5%)
Query: 120 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 179
LP N KNR +ILP D L+++ + E ++YINA + Y P +I TQ PLP T
Sbjct: 1223 LPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTV 1281
Query: 180 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWA 238
DFW++VL +VML + + C YWP E + +G I VE +S + ++D
Sbjct: 1282 KDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWP--ENGVHRHGPIQVEFVSADLEEDII 1337
Query: 239 CRHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKG 291
R FRI A QD V F + WP + T + S L+ + V +++ +G
Sbjct: 1338 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYR-DTPVSKRSFLKLIRQVDKWQEEYNGGEG 1396
Query: 292 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 351
++HC G GR+GTF A+ + + +R VD+ V +R+ + +MV +QY F ++
Sbjct: 1397 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE 1456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,694,082
Number of Sequences: 37866
Number of extensions: 582026
Number of successful extensions: 1800
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 1309
Number of HSP's gapped (non-prelim): 172
length of query: 377
length of database: 18,247,518
effective HSP length: 104
effective length of query: 273
effective length of database: 14,309,454
effective search space: 3906480942
effective search space used: 3906480942
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.