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Search of human proteins with 6912736
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912736 transient receptor potential cation channel,
subfamily C, member 5 [Homo sapiens]
(973 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912736 transient receptor potential cation channel, subfamil... 1969 0.0
gi|7706747 transient receptor potential cation channel, subfamil... 1251 0.0
gi|209863024 transient receptor potential cation channel, subfam... 1247 0.0
gi|209863026 transient receptor potential cation channel, subfam... 1239 0.0
gi|209863030 transient receptor potential cation channel, subfam... 1193 0.0
gi|209863028 transient receptor potential cation channel, subfam... 1065 0.0
gi|209863032 transient receptor potential cation channel, subfam... 783 0.0
gi|4507685 transient receptor potential cation channel, subfamil... 625 e-179
gi|194733735 transient receptor potential cation channel, subfam... 548 e-156
gi|4507687 transient receptor potential cation channel, subfamil... 548 e-156
gi|9966865 transient receptor potential cation channel, subfamil... 536 e-152
gi|5730102 transient receptor potential cation channel, subfamil... 520 e-147
gi|169216484 PREDICTED: similar to transient receptor potential ... 196 1e-49
gi|109689695 transient receptor potential cation channel, subfam... 102 2e-21
gi|4507689 transient receptor potential cation channel, subfamil... 92 2e-18
gi|94538366 transient receptor potential cation channel, subfami... 85 4e-16
gi|239754785 PREDICTED: similar to transient receptor potential ... 80 9e-15
gi|239749299 PREDICTED: similar to transient receptor potential ... 80 9e-15
gi|239743393 PREDICTED: hypothetical protein XP_002342847, parti... 80 9e-15
gi|239509090 PREDICTED: similar to transient receptor potential ... 80 9e-15
gi|148612863 transient receptor potential cation channel, subfam... 75 3e-13
gi|18921093 transient receptor potential cation channel, subfami... 73 1e-12
gi|154091312 transient receptor potential cation channel, subfam... 71 4e-12
gi|154091308 transient receptor potential cation channel, subfam... 71 4e-12
gi|154091310 transient receptor potential cation channel, subfam... 71 4e-12
gi|154091320 transient receptor potential cation channel, subfam... 71 4e-12
gi|154091318 transient receptor potential cation channel, subfam... 71 4e-12
gi|154091316 transient receptor potential cation channel, subfam... 71 4e-12
gi|154091314 transient receptor potential cation channel, subfam... 71 4e-12
gi|11225266 transient receptor potential cation channel, subfami... 69 3e-11
>gi|6912736 transient receptor potential cation channel, subfamily
C, member 5 [Homo sapiens]
Length = 973
Score = 1969 bits (5101), Expect = 0.0
Identities = 973/973 (100%), Positives = 973/973 (100%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN
Sbjct: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR
Sbjct: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
Query: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE
Sbjct: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
Query: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE
Sbjct: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
Query: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE
Sbjct: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
Query: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI
Sbjct: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
Query: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK
Sbjct: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
Query: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA
Sbjct: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
Query: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
Query: 541 YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV 600
YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV
Sbjct: 541 YYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFV 600
Query: 601 GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP 660
GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP
Sbjct: 601 GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPP 660
Query: 661 FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL 720
FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL
Sbjct: 661 FNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNL 720
Query: 721 VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR 780
VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR
Sbjct: 721 VKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQR 780
Query: 781 DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP 840
DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP
Sbjct: 781 DDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGP 840
Query: 841 SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN 900
SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN
Sbjct: 841 SLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN 900
Query: 901 LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK 960
LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK
Sbjct: 901 LSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHK 960
Query: 961 WGDGQEEQVTTRL 973
WGDGQEEQVTTRL
Sbjct: 961 WGDGQEEQVTTRL 973
>gi|7706747 transient receptor potential cation channel, subfamily
C, member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 1251 bits (3237), Expect = 0.0
Identities = 638/915 (69%), Positives = 747/915 (81%), Gaps = 23/915 (2%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S ++ Q +DLA+LK+AIKY QKE
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
Query: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
Query: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
Query: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PRE W+MWHPTL+AEA
Sbjct: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
Query: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
Query: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599
YY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
Query: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPP 659
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF+EGGTLP
Sbjct: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPT 655
Query: 660 PFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRN 719
PFN+IPSPKS YL W C K+ RR+ + + R AD+L ++ YQEV+RN
Sbjct: 656 PFNVIPSPKSLWYLIKWIWTHLCKKK---MRRKPESFGTIGRRAADNLRRHHQYQEVMRN 712
Query: 720 LVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRK----HPRSFSTSST 775
LVKRYVAAMIR++KT EGLTEENFKELKQDISSFR+EVL LL K + S S+
Sbjct: 713 LVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESS 772
Query: 776 ELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKS------KA 829
+ D+ +D G ++ K K +F+L H R + + G +
Sbjct: 773 NSADSDEKSDSEGNSKDKKK--NFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPR 830
Query: 830 ESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQME-K 888
E K +F+ +K GL + + +E ++ ++++S+ + +Q R Q+E +
Sbjct: 831 EKQRKVNFV-TDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESR 889
Query: 889 GKAEACSQSEINLSE 903
G A S LSE
Sbjct: 890 GLASRGDLSIPGLSE 904
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 1247 bits (3226), Expect = 0.0
Identities = 639/920 (69%), Positives = 749/920 (81%), Gaps = 28/920 (3%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S ++ Q +DLA+LK+AIKY QKE
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
Query: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
Query: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
Query: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PRE W+MWHPTL+AEA
Sbjct: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
Query: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
Query: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599
YY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
Query: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPP 659
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF+EGGTLP
Sbjct: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPT 655
Query: 660 PFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRN-----LRSFTERNADSLIQNQHYQ 714
PFN+IPSPKS YL W C K+ RR+ + +R+ R AD+L ++ YQ
Sbjct: 656 PFNVIPSPKSLWYLIKWIWTHLCKKK---MRRKPESFGTIGVRTQHRRAADNLRRHHQYQ 712
Query: 715 EVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRK----HPRSF 770
EV+RNLVKRYVAAMIR++KT EGLTEENFKELKQDISSFR+EVL LL K +
Sbjct: 713 EVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANA 772
Query: 771 STSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKS--- 827
S S+ + D+ +D G ++ K K +F+L H R + + G +
Sbjct: 773 SKESSNSADSDEKSDSEGNSKDKKK--NFSLFDLTTLIHPRSAAIASERHNISNGSALVV 830
Query: 828 ---KAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYS 884
E K +F+ +K GL + + +E ++ ++++S+ + +Q R
Sbjct: 831 QEPPREKQRKVNFV-TDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNI 889
Query: 885 QME-KGKAEACSQSEINLSE 903
Q+E +G A S LSE
Sbjct: 890 QLESRGLASRGDLSIPGLSE 909
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 1239 bits (3205), Expect = 0.0
Identities = 613/789 (77%), Positives = 700/789 (88%), Gaps = 10/789 (1%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S ++ Q +DLA+LK+AIKY QKE
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
Query: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
Query: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
Query: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PRE W+MWHPTL+AEA
Sbjct: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
Query: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
Query: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599
YY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
Query: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPP 659
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF+EGGTLP
Sbjct: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPT 655
Query: 660 PFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRN 719
PFN+IPSPKS YL W C K+ RR+ + + R AD+L ++ YQEV+RN
Sbjct: 656 PFNVIPSPKSLWYLIKWIWTHLCKKK---MRRKPESFGTIGRRAADNLRRHHQYQEVMRN 712
Query: 720 LVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLL-GNRKHPRSFSTSSTELS 778
LVKRYVAAMIR++KT EGLTEENFKELKQDISSFR+EVL LL G++ + +S E S
Sbjct: 713 LVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESS 772
Query: 779 QRDDNNDGS 787
D+++ S
Sbjct: 773 NSADSDEKS 781
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 1193 bits (3086), Expect = 0.0
Identities = 586/751 (78%), Positives = 670/751 (89%), Gaps = 9/751 (1%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S ++ Q +DLA+LK+AIKY QKE
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
Query: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
Query: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
Query: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PRE W+MWHPTL+AEA
Sbjct: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
Query: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
Query: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599
YY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
Query: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPP 659
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF+EGGTLP
Sbjct: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPT 655
Query: 660 PFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRN 719
PFN+IPSPKS YL W C K+ RR+ + + R AD+L ++ YQEV+RN
Sbjct: 656 PFNVIPSPKSLWYLIKWIWTHLCKKK---MRRKPESFGTIGRRAADNLRRHHQYQEVMRN 712
Query: 720 LVKRYVAAMIRNSKTHEGLTEENFKELKQDI 750
LVKRYVAAMIR++KT E ++ L+++I
Sbjct: 713 LVKRYVAAMIRDAKTEEVARQQAAGPLERNI 743
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 1065 bits (2753), Expect = 0.0
Identities = 520/636 (81%), Positives = 587/636 (92%), Gaps = 6/636 (0%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180
PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
Query: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240
CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
Query: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300
YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S ++ Q +DLA+LK+AIKY QKE
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
Query: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360
FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
Query: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420
+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
Query: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480
+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PRE W+MWHPTL+AEA
Sbjct: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
Query: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540
LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
Query: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599
YY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
Query: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHA 635
VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA A
Sbjct: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 783 bits (2022), Expect = 0.0
Identities = 417/689 (60%), Positives = 492/689 (71%), Gaps = 47/689 (6%)
Query: 230 LSKVENEFKAEYEELSQQCKLFAKDLLDQARSSR---ELEIILNHRDDHSEELDPQKYHD 286
L +ENE E EL ++ D L A +E++LNH+ E
Sbjct: 75 LIAIENE-NLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGE--------- 124
Query: 287 LAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSI 346
K+FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC IG LFP+ S+
Sbjct: 125 ------------KQFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSV 172
Query: 347 AYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWM 406
YLI+P+S LGLFI+KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWM
Sbjct: 173 CYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWM 232
Query: 407 ILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPR 466
ILPWVLGFIWGEIK+MWDGG +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+ PR
Sbjct: 233 ILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPR 292
Query: 467 EEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCL 526
E W+MWHPTL+AEALFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCL
Sbjct: 293 ESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCL 352
Query: 527 VLLAFANGLNQLYFYY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNL 585
VLLAFANGLNQLYFYY ET+ + CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NL
Sbjct: 353 VLLAFANGLNQLYFYYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL 408
Query: 586 YVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTK 645
YVTNVKA+HEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTK
Sbjct: 409 YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTK 468
Query: 646 LWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNAD 705
LWMSYF+EGGTLP PFN+IPSPKS YL W C K+ RR+ + + R AD
Sbjct: 469 LWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKK---MRRKPESFGTIGRRAAD 525
Query: 706 SLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRK 765
+L ++ YQEV+RNLVKRYVAAMIR++KT EGLTEENFKELKQDISSFR+EVL LL K
Sbjct: 526 NLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSK 585
Query: 766 ----HPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSS 821
+ S S+ + D+ +D G ++ K K +F+L H R +
Sbjct: 586 LSTIQSANASKESSNSADSDEKSDSEGNSKDKKK--NFSLFDLTTLIHPRSAAIASERHN 643
Query: 822 GAQGKS------KAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQH 875
+ G + E K +F+ +K GL + + +E ++ ++++S+ + +Q
Sbjct: 644 ISNGSALVVQEPPREKQRKVNFV-TDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQ 702
Query: 876 CMWQDIRYSQME-KGKAEACSQSEINLSE 903
R Q+E +G A S LSE
Sbjct: 703 AAGPLERNIQLESRGLASRGDLSIPGLSE 731
Score = 196 bits (499), Expect = 7e-50
Identities = 96/126 (76%), Positives = 118/126 (93%)
Query: 1 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60
MAQ YYK+ +PYRDRIPL+IVRAE+ELS EKA+LNAVEKGDYA+VK++L+EAEIY+
Sbjct: 1 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
Query: 61 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120
+NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
Query: 121 PSGEKQ 126
PSGEKQ
Sbjct: 121 PSGEKQ 126
>gi|4507685 transient receptor potential cation channel, subfamily
C, member 1 [Homo sapiens]
Length = 759
Score = 625 bits (1611), Expect = e-179
Identities = 337/744 (45%), Positives = 486/744 (65%), Gaps = 45/744 (6%)
Query: 28 ELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIME 87
E + EK FL A +KGDY VK+ L+E ++NINC+D LGR+A+ I IENENL+I++
Sbjct: 43 ENTLNEKLFLLACDKGDYYMVKKILEENSSG-DLNINCVDVLGRNAVTITIENENLDILQ 101
Query: 88 LLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIM 147
LLL++ G +L+ + P ++S T D+ P++
Sbjct: 102 LLLDY-----------------GCQKLMERIQNP-------------EYST-TMDVAPVI 130
Query: 148 LAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPS 207
LAAH NNYEI+ +L+++ V++P+PH + C C C + ++ DSLRHSR RL+IY+ LASP+
Sbjct: 131 LAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPA 190
Query: 208 LIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEI 267
LI L+ EDPIL AF L +LKELS VE EF+ +YEEL++QCK+FAKDLL QAR+SRELE+
Sbjct: 191 LIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEV 250
Query: 268 ILNHRDDHSEELDP----QKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWR 323
ILNH E LD ++ +L++LK+AIKY+QKEFV+Q NCQQ L T+W+ G+R
Sbjct: 251 ILNHTSS-DEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYR 309
Query: 324 RKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLL 383
RK K++T +T+G +P+LS+ YLI+P+S G I PF+KFI H ASY TFL +L L
Sbjct: 310 RKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNL 369
Query: 384 ASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMN 443
S + GP ++++++ W++G IW +IK +W G +++ + N + F MN
Sbjct: 370 YSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMN 429
Query: 444 SLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHL 503
SLYLAT +LK+VA+ K++ R++W+ +HPTL+AE LFA +N+LS LRL ++T +S L
Sbjct: 430 SLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSIL 489
Query: 504 GPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQ-N 562
GPLQIS+G+ML D KFL ++ LVL +F GL QLY T E +C GI CE+Q N
Sbjct: 490 GPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS--KEQKDCVGIFCEQQSN 547
Query: 563 NAFSTLFETLQSLFWSVFGLLN--LYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNML 620
+ F + T +LFW +F L + ++VT E FVGA + GTYNV+ ++VL +L
Sbjct: 548 DTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLL 607
Query: 621 IAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNT 680
+AM++ S+QLIA+H D EWKFAR KLW+SYFD+ TLPPPFNIIPSPK+ Y+ + +
Sbjct: 608 VAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKW 667
Query: 681 FCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTE 740
C +R+ +L+ + RN ++++YQ+V+ LV RY+ +M + ++ + T
Sbjct: 668 ICSHTSKGKVKRQNSLKEW--RNLKQK-RDENYQKVMCCLVHRYLTSMRQKMQSTDQATV 724
Query: 741 ENFKELKQDISSFRYEVLDLLGNR 764
EN EL+QD+S FR E+ DLLG R
Sbjct: 725 ENLNELRQDLSKFRNEIRDLLGFR 748
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 548 bits (1412), Expect = e-156
Identities = 316/805 (39%), Positives = 468/805 (58%), Gaps = 90/805 (11%)
Query: 27 TELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIM 86
T L+AEE+ FL+A E G+ V++ L+E++ +N+NC+D +G++AL +A+ NE+LE+
Sbjct: 107 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 163
Query: 87 ELLLNHS--VYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTL-----MMDTQF--- 136
ELLL +GDALL AI K V VE +L++ + K++ + D F
Sbjct: 164 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 223
Query: 137 ----SEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRH 192
+ F+PDITPI+LAAH YE++ +L+ K I RPH C C +C+ DS H
Sbjct: 224 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 283
Query: 193 SRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFA 252
SRSR+N YK LASP+ ++LSSEDP+LTA L EL +L+ +E EFK +Y +LS QCK F
Sbjct: 284 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 343
Query: 253 KDLLDQARSSRELEIILNHRDDHSEELDPQKYH-DLAKLKVAIKYHQKEFVAQPNCQQLL 311
+LD R S E+E ILN + +E L+ ++ L+++K+AIKY K+FVA PNCQQ L
Sbjct: 344 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 403
Query: 312 ATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHT 371
T+WY+ G R + +K L + + P L+I Y I+P S LG ++ PF+KF+ H
Sbjct: 404 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 463
Query: 372 ASYLTFLFMLLLASQ----------HIVRTD-----LHVQGPPPTVVEWMILPWVLGFIW 416
AS++ FL +L+ + +I TD V+ T E +I+ WVLG +W
Sbjct: 464 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 523
Query: 417 GEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSR------------ 464
E KE+W G EYI WN++DF M S+++A + + +A+++ ++
Sbjct: 524 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 583
Query: 465 --------------PREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
R++W P +I+E L+AI+ +LS R+ + AN GPLQISL
Sbjct: 584 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 643
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E
Sbjct: 644 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYY--------------LGAKVNAAFTTVEE 689
Query: 571 TLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQL 630
+ ++LFWS+FGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ
Sbjct: 690 SFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQE 749
Query: 631 IADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLY-LGNWFNNTFCPKRDPD- 688
I D +D+EWKFAR+KLW+SYFD+G TLPPPF+++PSPKSF+Y + N C +R
Sbjct: 750 IEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQK 809
Query: 689 ------GRRRRR-------NLRSFTERNADSLI-QNQHYQEVIRNLVKRYVAAMIRNSKT 734
G + R N R F + +S++ Q YQ++++ L+KRYV + K
Sbjct: 810 DIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYV-LKAQVDKE 868
Query: 735 HEGLTEENFKELKQDISSFRYEVLD 759
++ + E KE+KQDISS RYE+L+
Sbjct: 869 NDEVNEGELKEIKQDISSLRYELLE 893
>gi|4507687 transient receptor potential cation channel, subfamily
C, member 3 isoform b [Homo sapiens]
Length = 848
Score = 548 bits (1412), Expect = e-156
Identities = 316/805 (39%), Positives = 468/805 (58%), Gaps = 90/805 (11%)
Query: 27 TELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIM 86
T L+AEE+ FL+A E G+ V++ L+E++ +N+NC+D +G++AL +A+ NE+LE+
Sbjct: 34 TSLTAEEERFLDAAEYGNIPVVRKMLEESK---TLNVNCVDYMGQNALQLAVGNEHLEVT 90
Query: 87 ELLLNHS--VYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTL-----MMDTQF--- 136
ELLL +GDALL AI K V VE +L++ + K++ + D F
Sbjct: 91 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150
Query: 137 ----SEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRH 192
+ F+PDITPI+LAAH YE++ +L+ K I RPH C C +C+ DS H
Sbjct: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210
Query: 193 SRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFA 252
SRSR+N YK LASP+ ++LSSEDP+LTA L EL +L+ +E EFK +Y +LS QCK F
Sbjct: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270
Query: 253 KDLLDQARSSRELEIILNHRDDHSEELDPQKYH-DLAKLKVAIKYHQKEFVAQPNCQQLL 311
+LD R S E+E ILN + +E L+ ++ L+++K+AIKY K+FVA PNCQQ L
Sbjct: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330
Query: 312 ATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHT 371
T+WY+ G R + +K L + + P L+I Y I+P S LG ++ PF+KF+ H
Sbjct: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390
Query: 372 ASYLTFLFMLLLASQ----------HIVRTD-----LHVQGPPPTVVEWMILPWVLGFIW 416
AS++ FL +L+ + +I TD V+ T E +I+ WVLG +W
Sbjct: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450
Query: 417 GEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSR------------ 464
E KE+W G EYI WN++DF M S+++A + + +A+++ ++
Sbjct: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510
Query: 465 --------------PREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
R++W P +I+E L+AI+ +LS R+ + AN GPLQISL
Sbjct: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
GR + DI KF+ ++ +V AF G+ LY YY K N AF+T+ E
Sbjct: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYY--------------LGAKVNAAFTTVEE 616
Query: 571 TLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQL 630
+ ++LFWS+FGL + +K H+F E +G ++G YNV +VVLLNMLIAM+N+SYQ
Sbjct: 617 SFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQE 676
Query: 631 IADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLY-LGNWFNNTFCPKRDPD- 688
I D +D+EWKFAR+KLW+SYFD+G TLPPPF+++PSPKSF+Y + N C +R
Sbjct: 677 IEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQK 736
Query: 689 ------GRRRRR-------NLRSFTERNADSLI-QNQHYQEVIRNLVKRYVAAMIRNSKT 734
G + R N R F + +S++ Q YQ++++ L+KRYV + K
Sbjct: 737 DIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYV-LKAQVDKE 795
Query: 735 HEGLTEENFKELKQDISSFRYEVLD 759
++ + E KE+KQDISS RYE+L+
Sbjct: 796 NDEVNEGELKEIKQDISSLRYELLE 820
>gi|9966865 transient receptor potential cation channel, subfamily
C, member 7 [Homo sapiens]
Length = 862
Score = 536 bits (1381), Expect = e-152
Identities = 316/812 (38%), Positives = 456/812 (56%), Gaps = 103/812 (12%)
Query: 27 TELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIM 86
T L+ EE+ FL++ E G+ V++ L+E++ +N NC+D +G++AL +A+ NE+LE+
Sbjct: 38 TSLTPEEERFLDSAEYGNIPVVRKMLEESK---TLNFNCVDYMGQNALQLAVGNEHLEVT 94
Query: 87 ELLLNHS--VYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSE------ 138
ELLL VGDALL AI K V VE +L++ + +++ ++ + +
Sbjct: 95 ELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAY 154
Query: 139 ------FTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRH 192
F+ DITPI+LAAH YEI+ +L+ K I RPH C C EC DS H
Sbjct: 155 DEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSH 214
Query: 193 SRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFA 252
SRSR+N YK LAS + ++LSSEDP+LTA L EL L+ +E EFK +Y +LS QCK F
Sbjct: 215 SRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFV 274
Query: 253 KDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLA 312
+LD R + E+E ILN D + + L+++K+AIKY K+FVA PNCQQ L
Sbjct: 275 VGVLDLCRDTEEVEAILNG-DVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLL 333
Query: 313 TLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTA 372
T+WY+ G R++ VK L + P L+IAY I+P S LG ++ PF+KF+ H
Sbjct: 334 TMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAV 393
Query: 373 SYLTFLFMLLLASQHIVR----------TD-----LHVQGPPPTVVEWMILPWVLGFIWG 417
S+ FL +L++ + TD V+ + E +I+ WVLG IW
Sbjct: 394 SFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWS 453
Query: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVK-----------------Y 460
E KE+W+ G EY+ WNL+DF M S+++A+ + + +A++K +
Sbjct: 454 ECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLH 513
Query: 461 NGSRP---------REEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLG 511
N S P R++W P +I+E L+AI+ +LS R+ + AN GPLQISLG
Sbjct: 514 NVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLG 573
Query: 512 RMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFET 571
R + DI KF+ I+ +V +AF G+ LY YY R K N AF+T+ E+
Sbjct: 574 RTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY--------------RGAKYNPAFTTVEES 619
Query: 572 LQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 631
++LFWS+FGL + +K H+F E +G ++G YNV +VVLLNMLIAM+NNSYQ I
Sbjct: 620 FKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEI 679
Query: 632 ADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYL------------------ 673
+ AD+EWKFAR KLW+SYFDEG TLP PFN++PSPKSF YL
Sbjct: 680 EEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKS 739
Query: 674 ------GNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAA 727
N+ F R G R NL + ++L + YQ++++ L+KRYV
Sbjct: 740 CENDLEMGMLNSKFKKTRYQAGMRNSENLTA-----NNTLSKPTRYQKIMKRLIKRYV-L 793
Query: 728 MIRNSKTHEGLTEENFKELKQDISSFRYEVLD 759
+ + ++ + E KE+KQDISS RYE+L+
Sbjct: 794 KAQVDRENDEVNEGELKEIKQDISSLRYELLE 825
>gi|5730102 transient receptor potential cation channel, subfamily
C, member 6 [Homo sapiens]
Length = 931
Score = 520 bits (1339), Expect = e-147
Identities = 309/828 (37%), Positives = 461/828 (55%), Gaps = 115/828 (13%)
Query: 27 TELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIM 86
T LS EE+ FL+A E G+ V++ L+E +++N+NC+D +G++AL +A+ NE+LEI
Sbjct: 93 TSLSIEEERFLDAAEYGNIPVVRKMLEEC---HSLNVNCVDYMGQNALQLAVANEHLEIT 149
Query: 87 ELLLNHSVY--VGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSE------ 138
ELLL VGDALL AI K V VE +LS+ + K++ T ++ +
Sbjct: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209
Query: 139 ------FTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRH 192
F+ D+TPI+LAAH YEI+ L++K I RPH C C +C + DS H
Sbjct: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269
Query: 193 SRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFA 252
SRSR+N YK LASP+ ++LSSEDP++TA L EL L+ +E EFK +Y++LS QCK F
Sbjct: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329
Query: 253 KDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLA 312
LLD R++ E+E ILN + + D + +L++LK+AIKY K+FVA PNCQQ L
Sbjct: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGR-PNLSRLKLAIKYEVKKFVAHPNCQQQLL 388
Query: 313 TLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTA 372
++WY+ G R++ VK L + + P L++ Y +P S +G ++ PF+KF+ H A
Sbjct: 389 SIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAA 448
Query: 373 SYLTFLFMLLL-ASQHIVRTDL--------------HVQGPPPTVVEWMILPWVLGFIWG 417
S+ FL +L++ A+ T L ++ + +E +I+ WV+G IW
Sbjct: 449 SFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWA 508
Query: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY-------------------- 457
E KE+W G EY+ + WN++DF M +++ A+ + +A+
Sbjct: 509 ECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLT 568
Query: 458 -------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
VKY + R +W+ P +I+E L+AI+ +LS R+ + AN GPLQISL
Sbjct: 569 KVTLGDNVKYY-NLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 627
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
GR + DI KF+ I+ +V +AF G+ LY YY KQN AF+T+ E
Sbjct: 628 GRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGA--------------KQNEAFTTVEE 673
Query: 571 TLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQL 630
+ ++LFW++FGL + + H+F E +G ++G YNV ++VLLNMLIAM+N+S+Q
Sbjct: 674 SFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQE 733
Query: 631 IADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLY----LGNWFNNTF----- 681
I D AD+EWKFAR KLW SYF+EG TLP PFN++PSPKS Y L W + F
Sbjct: 734 IEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKK 793
Query: 682 -------------------------CPKRDPD----GRRRRRNLRSFTERNADSLIQ-NQ 711
K D G ++ ++RS + + +S +
Sbjct: 794 GFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPR 853
Query: 712 HYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLD 759
YQ++++ L+KRYV + K + + E KE+KQDISS RYE+L+
Sbjct: 854 QYQKIMKRLIKRYV-LQAQIDKESDEVNEGELKEIKQDISSLRYELLE 900
>gi|169216484 PREDICTED: similar to transient receptor potential
channel subfamily C member 6 [Homo sapiens]
Length = 304
Score = 196 bits (497), Expect = 1e-49
Identities = 112/300 (37%), Positives = 161/300 (53%), Gaps = 46/300 (15%)
Query: 413 GFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY--------------- 457
G IW E KE+W G EY+ + WN++DF M ++ A+ + A+
Sbjct: 17 GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAILSASFIARFRAFWHASKAQSITDASDT 76
Query: 458 ------------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGP 505
VKY S R EW+ P +++E L A++ +LS + + AN GP
Sbjct: 77 LKDLTKVTLGDNVKYY-SLARREWDPSDPRMVSEGLCAVAVVLSFSGIACILPANESFGP 135
Query: 506 LQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAF 565
LQ+SLG + DI +F+ I+ +V +AF G+ LY YY ID KQN AF
Sbjct: 136 LQMSLGGAVKDIFRFMLIFIMVFVAFMIGMFNLYSYY----IDV----------KQNEAF 181
Query: 566 STLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMN 625
+T+ E+ ++LFW+ F L + + H+F E +G ++G Y+V ++VLLNMLIAM+N
Sbjct: 182 TTVEESFKTLFWATFVLSAVKSVVINYSHKFIENIGYVLYGVYDVTMVIVLLNMLIAMIN 241
Query: 626 NSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKS----FLYLGNWFNNTF 681
+S Q I D AD+EWKFAR KLW S F EG LP PFN++P P S L L W + +
Sbjct: 242 SSLQEIEDDADVEWKFARAKLWFSCFGEGRALPVPFNLVPGPGSLFCLLLKLKGWISELY 301
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 102 bits (253), Expect = 2e-21
Identities = 106/449 (23%), Positives = 193/449 (42%), Gaps = 66/449 (14%)
Query: 227 LKELSKVENEFKA--EYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEEL---DP 281
LK L+KV+N+ A E EEL+ + + A +L + SS E D +E+L
Sbjct: 598 LKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDE---------DLAEQLLVYSC 648
Query: 282 QKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLF 341
+ + L++A++ + F+AQP Q L+ WY G K+W K++ C+ F+
Sbjct: 649 EAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWY-GEISRDTKNW--KIILCL---FII 702
Query: 342 PMLSIAYLISPRSNLG----------LFIKKPFIKFICHTASYLTFLFMLLLASQHIVRT 391
P++ ++ + + F PF+ F + Y+ FL + +++
Sbjct: 703 PLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA----YVLLM 758
Query: 392 DLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATIS 451
D H PP +V + + V E+++ + G Y D WN+MD ++A I
Sbjct: 759 DFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNG-VNYFTDLWNVMDTLGLFYFIAGIV 814
Query: 452 LKIVAYVK---YNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQI 508
++ + K Y+G +F + I+ +LRLI +FT + +LGP I
Sbjct: 815 FRLHSSNKSSLYSG----------------RVIFCLDYIIFTLRLIHIFTVSRNLGPKII 858
Query: 509 SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETR-------AIDEPNNCKGIRCEKQ 561
L RML+D+ FLF++ + ++AF + E R I EP + +
Sbjct: 859 MLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEP--YLAMFGQVP 916
Query: 562 NNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLI 621
++ T ++ F + F E++ + Y + + ++L+N+L+
Sbjct: 917 SDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLV 976
Query: 622 AMMNNSYQLIADHADIEWKFARTKLWMSY 650
AM + + ++ D WKF R L Y
Sbjct: 977 AMFGYTVGTVQENNDQVWKFQRYFLVQEY 1005
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 92.4 bits (228), Expect = 2e-18
Identities = 114/515 (22%), Positives = 200/515 (38%), Gaps = 111/515 (21%)
Query: 208 LIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEI 267
+I S+D I A LKELSK E + + E L+ L + R + +
Sbjct: 640 IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689
Query: 268 ILN-HRDDHSEELD-----PQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPG 321
+R D + + L++A++ +FV+ Q L +W+ G
Sbjct: 690 FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWW-GQLS 748
Query: 322 WRRKHWVVKLLTCMTIGFLFPMLSIAYLIS-----------PRSNLGLFIKKPFIKFICH 370
W V L CM FP+L + LIS P + F P + F +
Sbjct: 749 VDNGLWRVTL--CM---LAFPLL-LTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLN 802
Query: 371 TASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMW----DGG 426
SY FL + +++ D P P+ E I W+ + E+++++ + G
Sbjct: 803 ILSYFAFLCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECG 855
Query: 427 FTE----YIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALF 482
+ Y D+WN +D L++A ++ +++ Y G +
Sbjct: 856 LMKKAALYFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVIL 899
Query: 483 AISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYY 542
++ IL LRL+ +FT + LGP I + RM+ D+ FLF+ + +++F + +
Sbjct: 900 SLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHN 959
Query: 543 ETRAIDEPNNCKGIRCEKQNNAFSTLFE-TLQSLFWSVFGLLNLYVTNV----------- 590
E R LF + + ++FG + Y+ V
Sbjct: 960 ERRV-------------------DWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNG 1000
Query: 591 --------------KARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHAD 636
+ R F E++ + Y + + ++LLN+LIAM N ++Q + +H D
Sbjct: 1001 TDPYKPKCPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTD 1060
Query: 637 IEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFL 671
WKF R L Y PPPF ++ + F+
Sbjct: 1061 QIWKFQRHDLIEEYHGRPAA-PPPFILLSHLQLFI 1094
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 84.7 bits (208), Expect = 4e-16
Identities = 84/371 (22%), Positives = 163/371 (43%), Gaps = 77/371 (20%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T SYL +L LL +VR D P++ EW+++ +++ +
Sbjct: 823 FYNAPIVKFWFYTISYLGYL--LLFNYVILVRMDGW-----PSLQEWIVISYIVSLALEK 875
Query: 419 IKEMW---DGGFTEYIHDW----WNLMDFAMNSLYL--ATISLKIVAYVKYNGSRPREEW 469
I+E+ G ++ I W WN+ D S ++ A + L+ Y+ Y
Sbjct: 876 IREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYG-------- 927
Query: 470 EMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLL 529
++ + I +R++ +F N +LGP + +G+M++D+L F+ I +VL+
Sbjct: 928 ---------RVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLM 978
Query: 530 AFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFG-----LLN 584
+F +AI P ++ ++ +W ++G ++
Sbjct: 979 SFG---------VARQAILHP---------EEKPSWKLARNIFYMPYWMIYGEVFADQID 1020
Query: 585 LYVTNVK---ARHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQ 629
LY + + + E ++ + Y +++ ++L+N+LIA+ NN++
Sbjct: 1021 LYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFF 1080
Query: 630 LIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC-PKRDPD 688
+ ++ WKF R +L M++ D LPPP I+ S +Y+ + C KR+ D
Sbjct: 1081 EVKSISNQVWKFQRYQLIMTFHDR-PVLPPPMIIL----SHIYIIIMRLSGRCRKKREGD 1135
Query: 689 GRRRRRNLRSF 699
R R L+ F
Sbjct: 1136 QEERDRGLKLF 1146
>gi|239754785 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 42/183 (22%)
Query: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY-------------------- 457
E KE+W G EY+ + WN++DF M ++ A + A+
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 458 -------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
VKY + R EW P +++E L A++ +LS + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYY-NLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIG--------------AKQNEAFTTLKR 168
Query: 571 TLQ 573
L+
Sbjct: 169 VLR 171
>gi|239749299 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 42/183 (22%)
Query: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY-------------------- 457
E KE+W G EY+ + WN++DF M ++ A + A+
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 458 -------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
VKY + R EW P +++E L A++ +LS + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYY-NLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIG--------------AKQNEAFTTLKR 168
Query: 571 TLQ 573
L+
Sbjct: 169 VLR 171
>gi|239743393 PREDICTED: hypothetical protein XP_002342847, partial
[Homo sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 42/183 (22%)
Query: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY-------------------- 457
E KE+W G EY+ + WN++DF M ++ A + A+
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 458 -------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
VKY + R EW P +++E L A++ +LS + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYY-NLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIG--------------AKQNEAFTTLKR 168
Query: 571 TLQ 573
L+
Sbjct: 169 VLR 171
>gi|239509090 PREDICTED: similar to transient receptor potential
cation channel, subfamily C, member 6, partial [Homo
sapiens]
Length = 182
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/183 (30%), Positives = 82/183 (44%), Gaps = 42/183 (22%)
Query: 418 EIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAY-------------------- 457
E KE+W G EY+ + WN++DF M ++ A + A+
Sbjct: 4 ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63
Query: 458 -------VKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISL 510
VKY + R EW P +++E L A++ +LS + + AN GPLQ SL
Sbjct: 64 EVTLGDNVKYY-NLARREWVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122
Query: 511 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE 570
G + DI +F+ I+ +V +AF G+ LY YY KQN AF+TL
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIG--------------AKQNEAFTTLKR 168
Query: 571 TLQ 573
L+
Sbjct: 169 VLR 171
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 75.1 bits (183), Expect = 3e-13
Identities = 70/324 (21%), Positives = 138/324 (42%), Gaps = 54/324 (16%)
Query: 359 FIKKPFIKFICHTASYLTFL----FMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGF 414
F P +KF +T +YL FL F++L+ + + P+V EW+++ ++ +
Sbjct: 848 FYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQL-----------PSVQEWIVIAYIFTY 896
Query: 415 IWGEIKEMW---DGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
+++E++ G + I W++ D+ S +A IS I +++
Sbjct: 897 AIEKVREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYD 954
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
H + ++ ++ I +RL+ N GP + +G+M+ ++ + I LVLL+F
Sbjct: 955 NHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF 1014
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ + +E + ++ + + +W +FG + Y +V
Sbjct: 1015 GVPRKAILYPHEAPS------------------WTLAKDIVFHPYWMIFGEVYAYEIDVC 1056
Query: 592 ARHE-----------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWK 640
A T F+ A Y + ++++N+LIA NN Y + ++I WK
Sbjct: 1057 ANDSVIPQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWK 1112
Query: 641 FARTKLWMSYFDEGGTLPPPFNII 664
+ R M+Y E LPPP I+
Sbjct: 1113 YQRYHFIMAY-HEKPVLPPPLIIL 1135
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 72.8 bits (177), Expect = 1e-12
Identities = 71/316 (22%), Positives = 129/316 (40%), Gaps = 51/316 (16%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +YL FL + T L P P+V EW++ ++
Sbjct: 834 FYSAPIVKFWFYTMAYLAFLMLFTY-------TVLVEMQPQPSVQEWLVSIYIFTNAIEV 886
Query: 419 IKEMW---DGGFTE----YIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E+ G FT+ +I ++WNL + L+ A L+ G P
Sbjct: 887 VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRW-------GDPP------ 933
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
+H ++ I I RL+ F N H GP + +M ++ + I +VLL+F
Sbjct: 934 FHTA--GRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLL---NLYVT 588
K I K+ ++S + + +W ++G + + V
Sbjct: 992 GVAR------------------KAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVC 1033
Query: 589 NVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWM 648
+ + F+ + Y + ++++N+LIA NN Y + ++ WK+ R + M
Sbjct: 1034 SSQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIM 1093
Query: 649 SYFDEGGTLPPPFNII 664
+Y E LPPP ++
Sbjct: 1094 TY-HEKPWLPPPLILL 1108
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 724 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 777 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 829
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 830 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 882 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 921
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 922 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 981
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 982 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1034
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 737 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 789
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 790 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 842
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 843 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 894
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 895 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 934
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 935 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 994
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 995 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1047
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 727 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 779
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 780 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 832
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 833 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 884
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 885 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 924
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 925 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 984
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 985 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1037
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 712 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 764
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 765 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 817
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 818 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 869
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 870 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 909
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 910 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 969
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 970 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1022
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 702 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 754
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 755 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 807
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 808 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 859
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 860 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 899
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 900 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 959
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 960 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1012
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 714 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 766
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 767 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 819
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 820 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 871
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 872 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 911
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 912 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 971
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 972 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1024
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 71.2 bits (173), Expect = 4e-12
Identities = 76/360 (21%), Positives = 154/360 (42%), Gaps = 77/360 (21%)
Query: 359 FIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGE 418
F P +KF +T +Y+ +L + +IV + P+ EW+++ ++ +
Sbjct: 865 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 917
Query: 419 IKE--MWDGG-----FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEM 471
++E M + G ++ ++WN+ D L+ + L++ + R
Sbjct: 918 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGR------- 970
Query: 472 WHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 531
++ ++ I +RL+ +F N +LGP + +G+M++D++ F+ I +VL++F
Sbjct: 971 --------VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 1022
Query: 532 ANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVK 591
+ F PN + K N F +W ++G ++ +
Sbjct: 1023 GVARQAILF---------PNEEPSWKLAK--NIF-------YMPYWMIYG--EVFADQID 1062
Query: 592 ---ARHEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADH 634
++E E ++ + Y +++ ++L+N+LIA+ NN++ +
Sbjct: 1063 PPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSI 1122
Query: 635 ADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKR----DPDGR 690
++ WKF R +L M+ F E LPPP I F ++ F + C R DPD R
Sbjct: 1123 SNQVWKFQRYQLIMT-FHERPVLPPPLII------FSHMTMIFQHLCCRWRKHESDPDER 1175
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 68.6 bits (166), Expect = 3e-11
Identities = 70/327 (21%), Positives = 133/327 (40%), Gaps = 65/327 (19%)
Query: 363 PFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEM 422
P F+ + Y FLF+ +++ D P+ E + WV + EI++
Sbjct: 731 PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQG 786
Query: 423 WDGG--------FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHP 474
+ FT Y+ D WN D L++ ++ +++ G
Sbjct: 787 FFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAG------------ 834
Query: 475 TLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 534
+ A+ ++ +LRLI +F + LGP I + RM+ D+ FLF + L+A+
Sbjct: 835 ----RTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYG-- 888
Query: 535 LNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLF-ETLQSLFWSVFGLLN--------- 584
T+A+ P+ + +F L + +FG +
Sbjct: 889 -------VTTQALLHPH----------DGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARV 931
Query: 585 -------LYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADI 637
L + + ++ + T+ +++ V+L+N+LIAM + ++Q++ +AD+
Sbjct: 932 NCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADM 991
Query: 638 EWKFARTKLWMSYFDEGGTLPPPFNII 664
WKF R L + Y E L PPF ++
Sbjct: 992 FWKFQRYNLIVEY-HERPALAPPFILL 1017
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,912,031
Number of Sequences: 37866
Number of extensions: 1569183
Number of successful extensions: 5425
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 5042
Number of HSP's gapped (non-prelim): 395
length of query: 973
length of database: 18,247,518
effective HSP length: 112
effective length of query: 861
effective length of database: 14,006,526
effective search space: 12059618886
effective search space used: 12059618886
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.