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Search of human proteins with 66932916
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 739 0.0
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 739 0.0
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 641 0.0
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 581 e-166
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 548 e-156
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 338 6e-93
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 338 6e-93
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 338 6e-93
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 327 8e-90
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 322 3e-88
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 315 5e-86
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 294 7e-80
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 289 2e-78
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 274 1e-73
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 268 4e-72
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 266 3e-71
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 266 3e-71
gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens] 265 5e-71
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 264 1e-70
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 264 1e-70
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 264 1e-70
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 262 3e-70
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 259 3e-69
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 259 3e-69
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 256 2e-68
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 256 2e-68
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 256 2e-68
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 256 2e-68
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 255 5e-68
gi|149408126 nemo like kinase [Homo sapiens] 254 8e-68
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 739 bits (1909), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE 60
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
Sbjct: 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE 60
Query: 61 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH 120
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
Sbjct: 61 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH 120
Query: 121 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
Sbjct: 121 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Query: 181 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 240
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
Sbjct: 181 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 240
Query: 241 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK 300
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
Sbjct: 241 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK 300
Query: 301 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 360
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Sbjct: 301 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 360
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 739 bits (1909), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE 60
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
Sbjct: 1 MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE 60
Query: 61 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH 120
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
Sbjct: 61 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH 120
Query: 121 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
Sbjct: 121 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Query: 181 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 240
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
Sbjct: 181 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 240
Query: 241 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK 300
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
Sbjct: 241 LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK 300
Query: 301 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 360
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Sbjct: 301 RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS 360
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 641 bits (1653), Expect = 0.0
Identities = 313/374 (83%), Positives = 334/374 (89%), Gaps = 17/374 (4%)
Query: 1 MAAAAAAGAGP-----------------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY 43
MAAAAA G G EMV+GQ FDVGPRYT L YIGEGAYGMV SAY
Sbjct: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
Query: 44 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI 103
D+V K RVAIKKISPFEHQTYCQRTLREI+ILLRFRHEN+IGI DI+RA T+E M+DVYI
Sbjct: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
Query: 104 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
VQDLMETDLYKLLK+Q LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL+NTTCDL
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 164 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
KICDFGLAR+ADP+HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
Query: 224 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD 283
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN+KARNYL SLP K KV W +LFP +D
Sbjct: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
Query: 284 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL 343
SKALDLLD+MLTFNP+KRI VE+ALAHPYLEQYYDP+DEP+AE PF F MELDDLPKE+L
Sbjct: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 360
Query: 344 KELIFEETARFQPG 357
KELIF+ETARFQPG
Sbjct: 361 KELIFQETARFQPG 374
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 581 bits (1498), Expect = e-166
Identities = 285/345 (82%), Positives = 306/345 (88%), Gaps = 18/345 (5%)
Query: 1 MAAAAAAGAGP-----------------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY 43
MAAAAA G G EMV+GQ FDVGPRYT L YIGEGAYGMV SAY
Sbjct: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
Query: 44 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI 103
D+V K RVAIKKISPFEHQTYCQRTLREI+ILLRFRHEN+IGI DI+RA T+E M+DVYI
Sbjct: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
Query: 104 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
VQDLMETDLYKLLK+Q LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL+NTTCDL
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 164 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
KICDFGLAR+ADP+HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
Query: 224 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD 283
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN+KARNYL SLP K KV W +LFP +D
Sbjct: 241 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD 300
Query: 284 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAP 328
SKALDLLD+MLTFNP+KRI VE+ALAHPYLEQYYDP+DE + ++P
Sbjct: 301 SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDE-VGQSP 344
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 548 bits (1412), Expect = e-156
Identities = 278/374 (74%), Positives = 296/374 (79%), Gaps = 61/374 (16%)
Query: 1 MAAAAAAGAGP-----------------EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAY 43
MAAAAA G G EMV+GQ FDVGPRYT L YIGEGAYGMV SAY
Sbjct: 1 MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY 60
Query: 44 DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI 103
D+V K RVAIKKISPFEHQTYCQRTLREI+ILLRFRHEN+IGI DI+RA T+E M+DVYI
Sbjct: 61 DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI 120
Query: 104 VQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
VQDLMETDLYKLLK+Q LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL+NTTCDL
Sbjct: 121 VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL 180
Query: 164 KICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
KICDFGLAR+ADP+HDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
Sbjct: 181 KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 240
Query: 224 NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD 283
NRPIFPGKHYLDQLNHIL
Sbjct: 241 NRPIFPGKHYLDQLNHIL------------------------------------------ 258
Query: 284 SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKL 343
ALDLLD+MLTFNP+KRI VE+ALAHPYLEQYYDP+DEP+AE PF F MELDDLPKE+L
Sbjct: 259 --ALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL 316
Query: 344 KELIFEETARFQPG 357
KELIF+ETARFQPG
Sbjct: 317 KELIFQETARFQPG 330
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 338 bits (866), Expect = 6e-93
Identities = 174/341 (51%), Positives = 235/341 (68%), Gaps = 6/341 (1%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLR 77
FDVG Y + IG GAYG+V SA + +VAIKKI + F+ T +RTLRE+KIL
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 FRHENIIGINDIIRAPTIE--QMKDVYIVQDLMETDLYKLL-KTQHLSNDHICYFLYQIL 134
F+H+NII I DI+R PT+ + K VY+V DLME+DL++++ +Q L+ +H+ YFLYQ+L
Sbjct: 109 FKHDNIIAIKDILR-PTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 167
Query: 135 RGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDHTGFLTEYVATRWY 193
RGLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWY
Sbjct: 168 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 227
Query: 194 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 253
RAPE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS +
Sbjct: 228 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 287
Query: 254 CIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
+ + R Y+ SLP + VPW ++P AD +AL LL +ML F P RI AL HP+L
Sbjct: 288 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 347
Query: 314 EQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARF 354
+Y+DP DEP PF F + + L +E++KE I E F
Sbjct: 348 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 338 bits (866), Expect = 6e-93
Identities = 174/341 (51%), Positives = 235/341 (68%), Gaps = 6/341 (1%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLR 77
FDVG Y + IG GAYG+V SA + +VAIKKI + F+ T +RTLRE+KIL
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 FRHENIIGINDIIRAPTIE--QMKDVYIVQDLMETDLYKLL-KTQHLSNDHICYFLYQIL 134
F+H+NII I DI+R PT+ + K VY+V DLME+DL++++ +Q L+ +H+ YFLYQ+L
Sbjct: 109 FKHDNIIAIKDILR-PTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 167
Query: 135 RGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDHTGFLTEYVATRWY 193
RGLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWY
Sbjct: 168 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 227
Query: 194 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 253
RAPE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS +
Sbjct: 228 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 287
Query: 254 CIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
+ + R Y+ SLP + VPW ++P AD +AL LL +ML F P RI AL HP+L
Sbjct: 288 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 347
Query: 314 EQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARF 354
+Y+DP DEP PF F + + L +E++KE I E F
Sbjct: 348 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 338 bits (866), Expect = 6e-93
Identities = 174/341 (51%), Positives = 235/341 (68%), Gaps = 6/341 (1%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLR 77
FDVG Y + IG GAYG+V SA + +VAIKKI + F+ T +RTLRE+KIL
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 FRHENIIGINDIIRAPTIE--QMKDVYIVQDLMETDLYKLL-KTQHLSNDHICYFLYQIL 134
F+H+NII I DI+R PT+ + K VY+V DLME+DL++++ +Q L+ +H+ YFLYQ+L
Sbjct: 109 FKHDNIIAIKDILR-PTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 167
Query: 135 RGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDHTGFLTEYVATRWY 193
RGLKY+HSA V+HRDLKPSNLL+N C+LKI DFG+AR + +H F+TEYVATRWY
Sbjct: 168 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 227
Query: 194 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 253
RAPE+ML+ YT++ID+WSVGCI EML+ R +FPGK+Y+ QL I+ +LG+PS +
Sbjct: 228 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQ 287
Query: 254 CIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
+ + R Y+ SLP + VPW ++P AD +AL LL +ML F P RI AL HP+L
Sbjct: 288 AVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL 347
Query: 314 EQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARF 354
+Y+DP DEP PF F + + L +E++KE I E F
Sbjct: 348 AKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDF 388
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 327 bits (839), Expect = 8e-90
Identities = 167/341 (48%), Positives = 233/341 (68%), Gaps = 9/341 (2%)
Query: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76
+++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L
Sbjct: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
Query: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135
+HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR
Sbjct: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195
GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
Query: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
Query: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
+ ARNY+ SL K+ + +F A+ A+DLL+KML + KRI QALAH Y Q
Sbjct: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310
Query: 316 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
Y+DP DEP+A+ P+ E DL ++ K L ++E F P
Sbjct: 311 YHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 350
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 322 bits (826), Expect = 3e-88
Identities = 163/341 (47%), Positives = 233/341 (68%), Gaps = 9/341 (2%)
Query: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76
+++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L
Sbjct: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
Query: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135
+HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR
Sbjct: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195
GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
Query: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG +++QL I+ + G+P +N +
Sbjct: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRM 250
Query: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
+ +ARNY+ SL K+ + +F A+ A+DLL+KML + KRI QALAH Y Q
Sbjct: 251 PSHEARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 310
Query: 316 YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
Y+DP DEP+A+ P+ E DL ++ K L ++E F P
Sbjct: 311 YHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISFVP 350
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 315 bits (806), Expect = 5e-86
Identities = 162/352 (46%), Positives = 232/352 (65%), Gaps = 9/352 (2%)
Query: 7 AGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYC 65
AG + + V++V R L +G GAYG VCSAYD + +VA+KK+S PF+ +
Sbjct: 6 AGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHA 65
Query: 66 QRTLREIKILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSND 124
+RT RE+++L +HEN+IG+ D+ A +IE +VY+V LM DL ++K Q LS++
Sbjct: 66 RRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDE 125
Query: 125 HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
H+ + +YQ+LRGLKYIHSA ++HRDLKPSN+ +N C+L+I DFGLAR AD + +
Sbjct: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------M 179
Query: 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 244
T YVATRWYRAPEIMLN Y +++DIWSVGCI+AE+L + +FPG Y+DQL I+ ++
Sbjct: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVV 239
Query: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
G+PS E L I + AR Y+ SLP + + +F A+ A+DLL +ML + +R+
Sbjct: 240 GTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA 299
Query: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
+ALAH Y QY+DP DEP AE P+ +E + E+ KEL ++E F+P
Sbjct: 300 AEALAHAYFSQYHDPEDEPEAE-PYDESVEAKERTLEEWKELTYQEVLSFKP 350
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 294 bits (753), Expect = 7e-80
Identities = 150/345 (43%), Positives = 221/345 (64%), Gaps = 9/345 (2%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V +++ Y + +++G GAYG VCSA D + +VAIKK+S PF+ + + +R RE+
Sbjct: 14 VNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL 73
Query: 73 KILLRFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
+L +HEN+IG+ D+ A ++ D Y+V M+TDL K++ + S + I Y +Y
Sbjct: 74 LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVY 132
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L+GLKYIHSA V+HRDLKP NL +N C+LKI DFGLAR AD + +T YV TR
Sbjct: 133 QMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE------MTGYVVTR 186
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
WYRAPE++L+ Y +++DIWSVGCI+AEML+ + +F GK YLDQL IL + G P E
Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
+ + + A++Y+ SLP + + +LFP A +A DLL+KML + KR+ QAL HP
Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHP 306
Query: 312 YLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQP 356
+ E + DP +E A+ PF +E + L ++ K+ I++E F P
Sbjct: 307 FFEPFRDPEEETEAQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSP 351
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 289 bits (740), Expect = 2e-78
Identities = 148/356 (41%), Positives = 223/356 (62%), Gaps = 13/356 (3%)
Query: 5 AAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQT 63
A +G + V ++V Y +L +G GAYG VCSA D +VAIKK+ PF+ +
Sbjct: 7 ARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL 66
Query: 64 YCQRTLREIKILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLS 122
+ +R RE+++L RHEN+IG+ D+ T++ D Y+V M TDL KL+K + L
Sbjct: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 126
Query: 123 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
D I + +YQ+L+GL+YIH+A ++HRDLKP NL +N C+LKI DFGLAR AD +
Sbjct: 127 EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----- 181
Query: 183 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 242
+T YV TRWYRAPE++LN YT+++DIWSVGCI+AEM++ + +F G +LDQL I+
Sbjct: 182 -MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK 240
Query: 243 ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI 302
+ G+P E + + + +A+NY+ LP K + + NA A++LL+KML + +R+
Sbjct: 241 VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV 300
Query: 303 EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEETARFQP 356
+ALAHPY E +D DEP + K+D DD+ + ++ K + ++E F+P
Sbjct: 301 TAGEALAHPYFESLHDTEDEPQVQ---KYDDSFDDVDRTLDEWKRVTYKEVLSFKP 353
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 274 bits (700), Expect = 1e-73
Identities = 152/334 (45%), Positives = 214/334 (64%), Gaps = 20/334 (5%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 78
FD+G RY +L +G G G+V SA DN RVAIKKI + Q+ + LREIKI+ R
Sbjct: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSV-KHALREIKIIRRL 72
Query: 79 RHENIIGINDIIRAPTIEQMKD----------VYIVQDLMETDLYKLLKTQHLSNDHICY 128
H+NI+ + +I+ P+ Q+ D VYIVQ+ METDL +L+ L +H
Sbjct: 73 DHDNIVKVFEIL-GPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
Query: 129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEY 187
F+YQ+LRGLKYIHSANVLHRDLKP+NL +NT LKI DFGLAR+ DP + H G L+E
Sbjct: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191
Query: 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---GIL 244
+ T+WYR+P ++L+ YTK+ID+W+ GCI AEML+ + +F G H L+Q+ IL ++
Sbjct: 192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 251
Query: 245 GSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEV 304
+++L +I + RN + PHK P +L P +ALD L+++LTF+P R+
Sbjct: 252 HEEDRQELLSVIPVYIRNDMTE-PHK---PLTQLLPGISREALDFLEQILTFSPMDRLTA 307
Query: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDL 338
E+AL+HPY+ Y P DEPI+ PF + E+DD+
Sbjct: 308 EEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDI 341
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 268 bits (686), Expect = 4e-72
Identities = 138/284 (48%), Positives = 193/284 (67%), Gaps = 14/284 (4%)
Query: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76
+++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L
Sbjct: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
Query: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135
+HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR
Sbjct: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195
GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
Query: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
Query: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPH 299
+ ARNY+ SL K+ + +F A+ LT PH
Sbjct: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLG------KLTIYPH 288
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 266 bits (679), Expect = 3e-71
Identities = 147/353 (41%), Positives = 226/353 (64%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
+L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + LFP+ S+A DLL KML +P
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 266 bits (679), Expect = 3e-71
Identities = 147/353 (41%), Positives = 226/353 (64%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
+L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+AEM+ ++ +FPG+ Y+DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEF 248
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + LFP+ S+A DLL KML +P
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|89276769 mitogen-activated protein kinase 4 [Homo sapiens]
Length = 587
Score = 265 bits (677), Expect = 5e-71
Identities = 138/327 (42%), Positives = 211/327 (64%), Gaps = 10/327 (3%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF 78
+D+G R+ + +G G G+V SA D+ +VA+KKI+ + ++ + LREIKI+ R
Sbjct: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSM-KHALREIKIIRRL 72
Query: 79 RHENIIGINDIIRAPTIEQMKDV------YIVQDLMETDLYKLLKTQHLSNDHICYFLYQ 132
H+NI+ + +++ + ++ YIVQ+ METDL +LL+ L+ +H F+YQ
Sbjct: 73 DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQ 132
Query: 133 ILRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEYVATR 191
+LRGLKYIHSANVLHRDLKP+N+ ++T LKI DFGLAR+ D + H G+L+E + T+
Sbjct: 133 LLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTK 192
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
WYR+P ++L+ YTK+ID+W+ GCILAEML+ R +F G H L+Q+ IL + +ED
Sbjct: 193 WYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREED 252
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
+ + L+ +S + K P +L P +S+A+D L+K+LTFNP R+ E L HP
Sbjct: 253 KDEL--LRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHP 310
Query: 312 YLEQYYDPSDEPIAEAPFKFDMELDDL 338
Y+ Y P DEP ++ PF+ + E+DD+
Sbjct: 311 YMSPYSCPEDEPTSQHPFRIEDEIDDI 337
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 264 bits (674), Expect = 1e-70
Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+
Sbjct: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E
Sbjct: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + +LFP++ S+A DLL KML +P
Sbjct: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E
Sbjct: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 264 bits (674), Expect = 1e-70
Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+
Sbjct: 53 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 171
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 227
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E
Sbjct: 228 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 286
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + +LFP++ S+A DLL KML +P
Sbjct: 287 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 345
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E
Sbjct: 346 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 397
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 264 bits (674), Expect = 1e-70
Identities = 148/353 (41%), Positives = 225/353 (63%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY NL IG GA G+VC+AYD V VAIKK+S PF++QT+ +R RE+
Sbjct: 15 VGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL 74
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
++ H+NII + ++ T+E+ +DVY+V +LM+ +L ++++ + L ++ + Y LY
Sbjct: 75 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLY 133
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTR 189
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEF 248
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + +LFP++ S+A DLL KML +P
Sbjct: 249 MK-KLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPA 307
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V+ AL HPY+ +YDP+ E A P +D +LD+ E+ KELI++E
Sbjct: 308 KRISVDDALQHPYINVWYDPA-EVEAPPPQIYDKQLDEREHTIEEWKELIYKE 359
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 262 bits (670), Expect = 3e-70
Identities = 127/249 (51%), Positives = 174/249 (69%), Gaps = 2/249 (0%)
Query: 108 METDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKIC 166
ME+DL++++ +Q L+ +H+ YFLYQ+LRGLKY+HSA V+HRDLKPSNLL+N C+LKI
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 167 DFGLAR-VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 225
DFG+AR + +H F+TEYVATRWYRAPE+ML+ YT++ID+WSVGCI EML+ R
Sbjct: 61 DFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARR 120
Query: 226 PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSK 285
+FPGK+Y+ QL I+ +LG+PS + + + R Y+ SLP + VPW ++P AD +
Sbjct: 121 QLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQ 180
Query: 286 ALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKE 345
AL LL +ML F P RI AL HP+L +Y+DP DEP PF F + + L +E++KE
Sbjct: 181 ALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKE 240
Query: 346 LIFEETARF 354
I E F
Sbjct: 241 AIVAEIEDF 249
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 259 bits (662), Expect = 3e-69
Identities = 147/348 (42%), Positives = 224/348 (64%), Gaps = 24/348 (6%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77
F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136
H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304
R Y+ + P + +LFP+ AD S+A DLL KML + KRI V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 259 bits (662), Expect = 3e-69
Identities = 147/348 (42%), Positives = 224/348 (64%), Gaps = 24/348 (6%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77
F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136
H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
E++L GY +++D+WSVGCI+ EM+ ++ +FPG+ Y+DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304
R Y+ + P + +LFP+ AD S+A DLL KML + KRI V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 256 bits (654), Expect = 2e-68
Identities = 147/348 (42%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77
F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136
H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304
R Y+ + P + +LFP+ AD S+A DLL KML + KRI V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 256 bits (654), Expect = 2e-68
Identities = 147/348 (42%), Positives = 221/348 (63%), Gaps = 24/348 (6%)
Query: 19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR 77
F V RY NL IG GA G+VC+AYD + + VAIKK+S PF++QT+ +R RE+ ++
Sbjct: 20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKC 79
Query: 78 FRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRG 136
H+NIIG+ ++ ++E+ +DVYIV +LM+ +L ++++ + L ++ + Y LYQ+L G
Sbjct: 80 VNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCG 138
Query: 137 LKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAP 196
+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A +T YV TR+YRAP
Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF----MMTPYVVTRYYRAP 194
Query: 197 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
E++L GY +++DIWSVGCI+ EM+ +FPG ++DQ N ++ LG+P E + +
Sbjct: 195 EVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-KL 252
Query: 257 NLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEV 304
R Y+ + P + +LFP+ AD S+A DLL KML + KRI V
Sbjct: 253 QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISV 312
Query: 305 EQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
++AL HPY+ +YDPS E A P D +LD+ E+ KELI++E
Sbjct: 313 DEALQHPYINVWYDPS-EAEAPPPKIPDKQLDEREHTIEEWKELIYKE 359
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 256 bits (654), Expect = 2e-68
Identities = 144/353 (40%), Positives = 221/353 (62%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
+L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + LFP+ S+A DLL KML +P
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 256 bits (654), Expect = 2e-68
Identities = 144/353 (40%), Positives = 221/353 (62%), Gaps = 24/353 (6%)
Query: 14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI 72
V F V RY L IG GA G+VC+A+D V + VA+KK+S PF++QT+ +R RE+
Sbjct: 15 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL 74
Query: 73 KILLRFRHENIIGINDIIRAP-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
+L H+NII + ++ T+E+ +DVY+V +LM+ +L +++ + L ++ + Y LY
Sbjct: 75 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLY 133
Query: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATR 191
Q+L G+K++HSA ++HRDLKPSN+++ + C LKI DFGLAR A + +T YV TR
Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF----MMTPYVVTR 189
Query: 192 WYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
+YRAPE++L GY +++DIWSVGCI+ E++ IF G ++DQ N ++ LG+PS E
Sbjct: 190 YYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEF 248
Query: 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPH 299
+ + RNY+ + P + + LFP+ S+A DLL KML +P
Sbjct: 249 MK-KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPD 307
Query: 300 KRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
KRI V++AL HPY+ +YDP+ E A P +D +L++ E+ KELI++E
Sbjct: 308 KRISVDEALRHPYITVWYDPA-EAEAPPPQIYDAQLEEREHAIEEWKELIYKE 359
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 255 bits (651), Expect = 5e-68
Identities = 125/240 (52%), Positives = 174/240 (72%), Gaps = 8/240 (3%)
Query: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76
+++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L
Sbjct: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
Query: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135
+HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR
Sbjct: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195
GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
Query: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 254 bits (649), Expect = 8e-68
Identities = 145/353 (41%), Positives = 216/353 (61%), Gaps = 27/353 (7%)
Query: 31 IGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDI 89
IG GA+G+V S D + RVA+KK+ + F++ C+R RE+K+L F+H+N++ DI
Sbjct: 144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDI 203
Query: 90 IRAPTIEQMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHR 148
++ P I+ +++Y+V +LM++DL+K++ + Q LS+DH+ FLYQILRGLKY+HSA +LHR
Sbjct: 204 LQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHR 263
Query: 149 DLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 208
D+KP NLL+N+ C LKICDFGLARV + D +T+ V T++YRAPEI++ S+ Y+ +
Sbjct: 264 DIKPGNLLVNSNCVLKICDFGLARVEELDESR--HMTQEVVTQYYRAPEILMGSRHYSNA 321
Query: 209 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLP 268
IDIWSVGCI AE+L R +F + + QL+ I +LG+PS E + A+ ++L P
Sbjct: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACE-GAKAHILRGP 380
Query: 269 HKN-KVP-WNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ----------- 315
HK +P L A +A+ LL +ML F+P KRI + ALAHPYL++
Sbjct: 381 HKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCK 440
Query: 316 ---------YYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 359
Y EP+ F E + ++KE+I + Q G R
Sbjct: 441 CCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNR 493
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,956,951
Number of Sequences: 37866
Number of extensions: 620002
Number of successful extensions: 3325
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 720
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 1188
Number of HSP's gapped (non-prelim): 1019
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.