Search of human proteins with 66773086

Search of human proteins with 66773086

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66773086 SH3-binding kinase 1 [Homo sapiens]
         (424 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66773086 SH3-binding kinase 1 [Homo sapiens]                       867   0.0  
gi|157676320 SH3-binding domain kinase family, member 2 [Homo sa...   213   3e-55
gi|149589021 doublecortin-like kinase 3 [Homo sapiens]                131   1e-30
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   126   3e-29
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   126   3e-29
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   126   3e-29
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   126   3e-29
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   125   7e-29
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   125   9e-29
gi|166295196 checkpoint kinase 1 [Homo sapiens]                       123   3e-28
gi|166295194 checkpoint kinase 1 [Homo sapiens]                       123   3e-28
gi|166295192 checkpoint kinase 1 [Homo sapiens]                       123   3e-28
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   121   1e-27
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   121   1e-27
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   121   1e-27
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   121   1e-27
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   121   1e-27
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]      117   2e-26
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]      117   2e-26
gi|38569460 SNF1-like kinase 2 [Homo sapiens]                         115   8e-26
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   115   1e-25
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]              113   3e-25
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]               113   3e-25
gi|4557511 death-associated protein kinase 3 [Homo sapiens]           113   3e-25
gi|32455269 serine/threonine kinase 32C [Homo sapiens]                113   3e-25
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   113   4e-25
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]     113   4e-25
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               112   5e-25
gi|109255245 serine/threonine kinase 17a [Homo sapiens]               112   6e-25
gi|116256471 SNF1-like kinase [Homo sapiens]                          112   8e-25

>gi|66773086 SH3-binding kinase 1 [Homo sapiens]
          Length = 424

 Score =  867 bits (2239), Expect = 0.0
 Identities = 424/424 (100%), Positives = 424/424 (100%)

Query: 1   MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG 60
           MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG
Sbjct: 1   MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELG 60

Query: 61  KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET 120
           KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET
Sbjct: 61  KGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFET 120

Query: 121 EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV 180
           EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV
Sbjct: 121 EDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENV 180

Query: 181 LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG 240
           LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG
Sbjct: 181 LLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFG 240

Query: 241 VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP 300
           VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP
Sbjct: 241 VLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEP 300

Query: 301 ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG 360
           ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG
Sbjct: 301 ERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG 360

Query: 361 SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI 420
           SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI
Sbjct: 361 SGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAI 420

Query: 421 EICV 424
           EICV
Sbjct: 421 EICV 424


>gi|157676320 SH3-binding domain kinase family, member 2 [Homo
           sapiens]
          Length = 348

 Score =  213 bits (542), Expect = 3e-55
 Identities = 117/273 (42%), Positives = 159/273 (58%), Gaps = 3/273 (1%)

Query: 34  EDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKN 93
           EDM  L+ +TL  ++V + YE VR LG+G YG+V LV ++  GT +ALK + K +T L+ 
Sbjct: 43  EDMMTLSAQTLVRAEVDELYEEVRPLGQGRYGRVLLVTHRQKGTPLALKQLPKPRTSLRG 102

Query: 94  FLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKR 153
           FL E  +  SL +   I+  + +  E+   Y F  E    GDL   I P+VGLP+  V R
Sbjct: 103 FLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHGDLMAFIQPKVGLPQPAVHR 162

Query: 154 CVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIP 213
           C  QL  AL+++H R LV+RD+KPENVL+ D  CRR KL DFG TR  G  ++     IP
Sbjct: 163 CAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIP 222

Query: 214 YTAPEVC-QAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWE-AASGADAFFEEFVRWQR 271
           YTAPE+C      +GL +   +D WA GVL+FC+LTG FPW+   + AD F+E+F+ WQ 
Sbjct: 223 YTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQA 282

Query: 272 GRLP-GLPSQWRRFTEPALRMFQRLLALEPERR 303
              P   P  W      A  + + LL   P RR
Sbjct: 283 SGQPRDRPQPWFGLAPAADALLRGLLDPHPRRR 315


>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
          Length = 648

 Score =  131 bits (330), Expect = 1e-30
 Identities = 94/272 (34%), Positives = 142/272 (52%), Gaps = 13/272 (4%)

Query: 44  LAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL--REVSIT 101
           + A++V KHYE  R +G G +  V    ++ T    A+K ++KS+ K K  +   E+ I 
Sbjct: 347 IIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILII 406

Query: 102 NSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLA 161
            SLS  P I+K+ +V +ET+       EY   GDLFD I   V  PE      +  L  A
Sbjct: 407 QSLSH-PNIVKLHEV-YETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKA 464

Query: 162 LDFMHGRQLVHRDIKPENVLLFDRECR--RVKLADFGMTRRVGCRVKRVSGTIPYTAPEV 219
           L  MH + +VHRD+KPEN+L+   E +   +KLADFG+ + V   +  V GT  Y APE+
Sbjct: 465 LVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEI 524

Query: 220 CQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPS 279
             + +  GL     VD+WA GV+++ +L G  P+ +        E F   Q G    LP 
Sbjct: 525 L-SEKGYGLE----VDMWAAGVILYILLCGFPPFRSPERDQD--ELFNIIQLGHFEFLPP 577

Query: 280 QWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
            W   ++ A  +  RLL ++P++R  A +V +
Sbjct: 578 YWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQ 609


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  126 bits (317), Expect = 3e-29
 Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   T L+   REV I   L+  P
Sbjct: 55  NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
           ++VHRD+K EN+LL D +   +K+ADFG +    VG ++    G+ PY APE+ Q  + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + +R L L P +RG  +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  126 bits (317), Expect = 3e-29
 Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   T L+   REV I   L+  P
Sbjct: 55  NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
           ++VHRD+K EN+LL D +   +K+ADFG +    VG ++    G+ PY APE+ Q  + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + +R L L P +RG  +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  126 bits (317), Expect = 3e-29
 Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   T L+   REV I   L+  P
Sbjct: 55  NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
           ++VHRD+K EN+LL D +   +K+ADFG +    VG ++    G+ PY APE+ Q  + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + +R L L P +RG  +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  126 bits (317), Expect = 3e-29
 Identities = 83/265 (31%), Positives = 146/265 (55%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   T L+   REV I   L+  P
Sbjct: 55  NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH-P 113

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 114 NIVKLFEVI-ETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 172

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
           ++VHRD+K EN+LL D +   +K+ADFG +    VG ++    G+ PY APE+ Q  + D
Sbjct: 173 RIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 231 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 278

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + +R L L P +RG  +++ +
Sbjct: 279 DCENLLKRFLVLNPIKRGTLEQIMK 303


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  125 bits (314), Expect = 7e-29
 Identities = 86/275 (31%), Positives = 149/275 (54%), Gaps = 24/275 (8%)

Query: 45  AASDVTKH---YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREV 98
           +A+D   H   Y L + +GKG + KV L  +  TG ++A+K ++K++   T L+   REV
Sbjct: 49  SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 108

Query: 99  SITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQL 158
            I   L+  P I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+
Sbjct: 109 RIMKILNH-PNIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166

Query: 159 GLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTA 216
             A+ + H + +VHRD+K EN+LL D +   +K+ADFG +    VG ++    G+ PY A
Sbjct: 167 VSAVQYCHQKYIVHRDLKAENLLL-DGD-MNIKIADFGFSNEFTVGNKLDTFCGSPPYAA 224

Query: 217 PEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPG 276
           PE+ Q  + DG      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P 
Sbjct: 225 PELFQGKKYDG----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPF 278

Query: 277 LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
             S           + ++LL L P +RG  +++ +
Sbjct: 279 YMS------TDCENLLKKLLVLNPIKRGSLEQIMK 307


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  125 bits (313), Expect = 9e-29
 Identities = 85/265 (32%), Positives = 145/265 (54%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L+R +GKG + KV L  +  TG ++A+K ++K++   + L+   REV I   L+  P
Sbjct: 58  NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNH-P 116

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA AG++FD +     + E   +   +Q+  A+ + H +
Sbjct: 117 NIVKLFEVI-ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 175

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+K EN+LL D E   +K+ADFG +    +G ++    G+ PY APE+ Q  + D
Sbjct: 176 NIVHRDLKAENLLL-DAEA-NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 233

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VD+W+ GV+++ +++G+ P++  +      E   R  RG+   +P       E
Sbjct: 234 G----PEVDIWSLGVILYTLVSGSLPFDGHN----LKELRERVLRGKY-RVPFYMSTDCE 284

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
             LR   R L L P +R   +++ +
Sbjct: 285 SILR---RFLVLNPAKRCTLEQIMK 306


>gi|166295196 checkpoint kinase 1 [Homo sapiens]
          Length = 476

 Score =  123 bits (309), Expect = 3e-28
 Identities = 80/258 (31%), Positives = 136/258 (52%), Gaps = 20/258 (7%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK--LKNFLREVSITNSLSSSPFI 110
           ++LV+ LG+G YG+V L V + T   +A+K V+  +     +N  +E+ I N + +   +
Sbjct: 9   WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHENV 67

Query: 111 IKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQL 170
           +K +    E    Y+F  EY   G+LFD I P +G+PE   +R   QL   + ++HG  +
Sbjct: 68  VKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126

Query: 171 VHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCR---VKRVSGTIPYTAPEVCQAGRA 225
            HRDIKPEN+LL +R+   +K++DFG+    R   R   + ++ GT+PY APE+ +    
Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184

Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
                   VDVW+ G+++  +L G  PW+  S +    +E+  W+  +    P  W++  
Sbjct: 185 HA----EPVDVWSCGIVLTAMLAGELPWDQPSDS---CQEYSDWKEKKTYLNP--WKKID 235

Query: 286 EPALRMFQRLLALEPERR 303
              L +  ++L   P  R
Sbjct: 236 SAPLALLHKILVENPSAR 253


>gi|166295194 checkpoint kinase 1 [Homo sapiens]
          Length = 476

 Score =  123 bits (309), Expect = 3e-28
 Identities = 80/258 (31%), Positives = 136/258 (52%), Gaps = 20/258 (7%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK--LKNFLREVSITNSLSSSPFI 110
           ++LV+ LG+G YG+V L V + T   +A+K V+  +     +N  +E+ I N + +   +
Sbjct: 9   WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHENV 67

Query: 111 IKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQL 170
           +K +    E    Y+F  EY   G+LFD I P +G+PE   +R   QL   + ++HG  +
Sbjct: 68  VKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126

Query: 171 VHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCR---VKRVSGTIPYTAPEVCQAGRA 225
            HRDIKPEN+LL +R+   +K++DFG+    R   R   + ++ GT+PY APE+ +    
Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184

Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
                   VDVW+ G+++  +L G  PW+  S +    +E+  W+  +    P  W++  
Sbjct: 185 HA----EPVDVWSCGIVLTAMLAGELPWDQPSDS---CQEYSDWKEKKTYLNP--WKKID 235

Query: 286 EPALRMFQRLLALEPERR 303
              L +  ++L   P  R
Sbjct: 236 SAPLALLHKILVENPSAR 253


>gi|166295192 checkpoint kinase 1 [Homo sapiens]
          Length = 476

 Score =  123 bits (309), Expect = 3e-28
 Identities = 80/258 (31%), Positives = 136/258 (52%), Gaps = 20/258 (7%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK--LKNFLREVSITNSLSSSPFI 110
           ++LV+ LG+G YG+V L V + T   +A+K V+  +     +N  +E+ I N + +   +
Sbjct: 9   WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI-NKMLNHENV 67

Query: 111 IKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQL 170
           +K +    E    Y+F  EY   G+LFD I P +G+PE   +R   QL   + ++HG  +
Sbjct: 68  VKFYGHRREGNIQYLFL-EYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGI 126

Query: 171 VHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCR---VKRVSGTIPYTAPEVCQAGRA 225
            HRDIKPEN+LL +R+   +K++DFG+    R   R   + ++ GT+PY APE+ +    
Sbjct: 127 THRDIKPENLLLDERD--NLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184

Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
                   VDVW+ G+++  +L G  PW+  S +    +E+  W+  +    P  W++  
Sbjct: 185 HA----EPVDVWSCGIVLTAMLAGELPWDQPSDS---CQEYSDWKEKKTYLNP--WKKID 235

Query: 286 EPALRMFQRLLALEPERR 303
              L +  ++L   P  R
Sbjct: 236 SAPLALLHKILVENPSAR 253


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  121 bits (303), Expect = 1e-27
 Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   + L+   REV I   L+  P
Sbjct: 52  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+K EN+LL D +   +K+ADFG +     G ++    G+ PY APE+ Q  + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + ++ L L P +RG  +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  121 bits (303), Expect = 1e-27
 Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   + L+   REV I   L+  P
Sbjct: 52  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+K EN+LL D +   +K+ADFG +     G ++    G+ PY APE+ Q  + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + ++ L L P +RG  +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  121 bits (303), Expect = 1e-27
 Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   + L+   REV I   L+  P
Sbjct: 52  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+K EN+LL D +   +K+ADFG +     G ++    G+ PY APE+ Q  + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + ++ L L P +RG  +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  121 bits (303), Expect = 1e-27
 Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   + L+   REV I   L+  P
Sbjct: 52  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 110

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 111 NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 169

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+K EN+LL D +   +K+ADFG +     G ++    G+ PY APE+ Q  + D
Sbjct: 170 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 228 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 275

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + ++ L L P +RG  +++ +
Sbjct: 276 DCENLLKKFLILNPSKRGTLEQIMK 300


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  121 bits (303), Expect = 1e-27
 Identities = 80/265 (30%), Positives = 144/265 (54%), Gaps = 21/265 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSP 108
           +Y L++ +GKG + KV L  +  TG ++A+K ++K++   + L+   REV I   L+  P
Sbjct: 19  NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNH-P 77

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            I+K+F+V+ ETE       EYA  G++FD +     + E   +   +Q+  A+ + H +
Sbjct: 78  NIVKLFEVI-ETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 136

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRR--VGCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+K EN+LL D +   +K+ADFG +     G ++    G+ PY APE+ Q  + D
Sbjct: 137 FIVHRDLKAENLLL-DAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 194

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
           G      VDVW+ GV+++ +++G+ P++  +  +    E V   + R+P   S       
Sbjct: 195 G----PEVDVWSLGVILYTLVSGSLPFDGQNLKE--LRERVLRGKYRIPFYMS------T 242

Query: 287 PALRMFQRLLALEPERRGPAKEVFR 311
               + ++ L L P +RG  +++ +
Sbjct: 243 DCENLLKKFLILNPSKRGTLEQIMK 267


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score =  117 bits (294), Expect = 2e-26
 Identities = 110/393 (27%), Positives = 169/393 (43%), Gaps = 56/393 (14%)

Query: 42  RTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL--REVS 99
           R   +S + + Y++ + +G G +  V   + + TG + ALK ++K+K   K  L   EVS
Sbjct: 382 RCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVS 441

Query: 100 ITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLG 159
           I   +     I+ V ++   TE       E    GDLFD I       E      V  L 
Sbjct: 442 ILRRVKHPNIIMLVEEMETATE--LFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLA 499

Query: 160 LALDFMHGRQLVHRDIKPENVLL--FDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAP 217
            AL ++HG  +VHRDIKPEN+L+  +    + +KL DFG+   V   +  V GT  Y AP
Sbjct: 500 NALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAP 559

Query: 218 EVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASG-ADAFFEEFVRWQRGRLPG 276
           E+  A    GL     VD+WA GV+ + +L G  P+ + +   +  F++ +    G+L  
Sbjct: 560 EII-AETGYGLK----VDIWAAGVITYILLCGFPPFRSENNLQEDLFDQIL---AGKLEF 611

Query: 277 LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRF------------LKHELTSELRRR 324
               W   T+ A  +  ++L +  E R  A ++               ++ E+T +L++ 
Sbjct: 612 PAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQ- 670

Query: 325 PSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG----------SGS------RPAPP 368
             H     P       G         +  T L + G          SG        P PP
Sbjct: 671 --HFNNALPKQNSTTTG------VSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPP 722

Query: 369 AVGSVPLP---VPVPVPVPVPVPVPEPGLAPQG 398
           +V  +P+P   VP P P   P P P P  AP G
Sbjct: 723 SVEEIPVPGEAVPAPTPPESPTPHPPPA-APGG 754


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score =  117 bits (294), Expect = 2e-26
 Identities = 110/393 (27%), Positives = 169/393 (43%), Gaps = 56/393 (14%)

Query: 42  RTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL--REVS 99
           R   +S + + Y++ + +G G +  V   + + TG + ALK ++K+K   K  L   EVS
Sbjct: 383 RCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVS 442

Query: 100 ITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLG 159
           I   +     I+ V ++   TE       E    GDLFD I       E      V  L 
Sbjct: 443 ILRRVKHPNIIMLVEEMETATE--LFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLA 500

Query: 160 LALDFMHGRQLVHRDIKPENVLL--FDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAP 217
            AL ++HG  +VHRDIKPEN+L+  +    + +KL DFG+   V   +  V GT  Y AP
Sbjct: 501 NALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAP 560

Query: 218 EVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASG-ADAFFEEFVRWQRGRLPG 276
           E+  A    GL     VD+WA GV+ + +L G  P+ + +   +  F++ +    G+L  
Sbjct: 561 EII-AETGYGLK----VDIWAAGVITYILLCGFPPFRSENNLQEDLFDQIL---AGKLEF 612

Query: 277 LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRF------------LKHELTSELRRR 324
               W   T+ A  +  ++L +  E R  A ++               ++ E+T +L++ 
Sbjct: 613 PAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQ- 671

Query: 325 PSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESG----------SGS------RPAPP 368
             H     P       G         +  T L + G          SG        P PP
Sbjct: 672 --HFNNALPKQNSTTTG------VSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPP 723

Query: 369 AVGSVPLP---VPVPVPVPVPVPVPEPGLAPQG 398
           +V  +P+P   VP P P   P P P P  AP G
Sbjct: 724 SVEEIPVPGEAVPAPTPPESPTPHPPPA-APGG 755


>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
          Length = 926

 Score =  115 bits (288), Expect = 8e-26
 Identities = 81/256 (31%), Positives = 135/256 (52%), Gaps = 21/256 (8%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSPF 109
           Y++   LGKG +  V L  ++ T T++A+K ++KS+     L+   REV I   L   P 
Sbjct: 20  YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDH-PH 78

Query: 110 IIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQ 169
           IIK++ V+ ET+       EYA  G++FD +     L E   +R   Q+  A+D+ HGR+
Sbjct: 79  IIKLYQVM-ETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRK 137

Query: 170 LVHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAGRADG 227
           +VHRD+K EN+LL +     +K+ADFG     + G  +    G+ PY APEV +  + +G
Sbjct: 138 IVHRDLKAENLLLDNN--MNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195

Query: 228 LAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEP 287
                 +D+W+ GV+++ ++ G  P++  +       + V   R R+P   S      E 
Sbjct: 196 ----PQLDIWSMGVVLYVLVCGALPFDGPT--LPILRQRVLEGRFRIPYFMS------ED 243

Query: 288 ALRMFQRLLALEPERR 303
              + +R+L L+P +R
Sbjct: 244 CEHLIRRMLVLDPSKR 259



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 17/38 (44%), Positives = 18/38 (47%), Gaps = 2/38 (5%)

Query: 359 SGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAP 396
           S SG R APP      L    P P P P P  +PG AP
Sbjct: 804 STSGPRAAPPL--PTQLQQQQPPPPPPPPPPRQPGAAP 839


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  115 bits (287), Expect = 1e-25
 Identities = 87/277 (31%), Positives = 141/277 (50%), Gaps = 22/277 (7%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVS--ITN-SLSSSP 108
           HY L   LG GT+GKV +  ++ TG K+A+K +N+ K +  + + ++   I N  L   P
Sbjct: 15  HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHP 74

Query: 109 FIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGR 168
            IIK++ V+    D ++   EY   G+LFD I     + E   +R  QQ+  A+D+ H  
Sbjct: 75  HIIKLYQVISTPTDFFM-VMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 133

Query: 169 QLVHRDIKPENVLLFDRECRRVKLADFGMTRRV--GCRVKRVSGTIPYTAPEVCQAGRAD 226
            +VHRD+KPENVLL        K+ADFG++  +  G  ++   G+  Y APEV  +GR  
Sbjct: 134 MVVHRDLKPENVLLDAH--MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI-SGR-- 188

Query: 227 GLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTE 286
            L     VD+W+ GV+++ +L G  P++     D       +  RG +  +P    R   
Sbjct: 189 -LYAGPEVDIWSCGVILYALLCGTLPFD-----DEHVPTLFKKIRGGVFYIPEYLNR--- 239

Query: 287 PALRMFQRLLALEPERRGPAKEV--FRFLKHELTSEL 321
               +   +L ++P +R   K++    + K +L S L
Sbjct: 240 SVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYL 276


>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
          Length = 586

 Score =  113 bits (283), Expect = 3e-25
 Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 22/272 (8%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLK---------NFLREVSITNS 103
           Y + + LG G  G+V L   + T  K+A+K ++K K  +          N   E+ I   
Sbjct: 263 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 322

Query: 104 LSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALD 163
           L+  P IIK+ +  F+ ED Y+   E    G+LFD +     L E T K    Q+ LA+ 
Sbjct: 323 LNH-PCIIKIKNF-FDAEDYYIVL-ELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 379

Query: 164 FMHGRQLVHRDIKPENVLLFDRE--CRRVKLADFGMTRRVG--CRVKRVSGTIPYTAPEV 219
           ++H   ++HRD+KPENVLL  +E  C  +K+ DFG ++ +G    ++ + GT  Y APEV
Sbjct: 380 YLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLMRTLCGTPTYLAPEV 438

Query: 220 CQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPS 279
             +    G   +  VD W+ GV++F  L+G  P+       +  ++      G+   +P 
Sbjct: 439 LVSVGTAG--YNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT---SGKYNFIPE 493

Query: 280 QWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
            W   +E AL + ++LL ++P+ R   +E  R
Sbjct: 494 VWAEVSEKALDLVKKLLVVDPKARFTTEEALR 525


>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
          Length = 543

 Score =  113 bits (283), Expect = 3e-25
 Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 22/272 (8%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLK---------NFLREVSITNS 103
           Y + + LG G  G+V L   + T  K+A+K ++K K  +          N   E+ I   
Sbjct: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279

Query: 104 LSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALD 163
           L+  P IIK+ +  F+ ED Y+   E    G+LFD +     L E T K    Q+ LA+ 
Sbjct: 280 LNH-PCIIKIKNF-FDAEDYYIVL-ELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336

Query: 164 FMHGRQLVHRDIKPENVLLFDRE--CRRVKLADFGMTRRVG--CRVKRVSGTIPYTAPEV 219
           ++H   ++HRD+KPENVLL  +E  C  +K+ DFG ++ +G    ++ + GT  Y APEV
Sbjct: 337 YLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLMRTLCGTPTYLAPEV 395

Query: 220 CQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPS 279
             +    G   +  VD W+ GV++F  L+G  P+       +  ++      G+   +P 
Sbjct: 396 LVSVGTAG--YNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQIT---SGKYNFIPE 450

Query: 280 QWRRFTEPALRMFQRLLALEPERRGPAKEVFR 311
            W   +E AL + ++LL ++P+ R   +E  R
Sbjct: 451 VWAEVSEKALDLVKKLLVVDPKARFTTEEALR 482


>gi|4557511 death-associated protein kinase 3 [Homo sapiens]
          Length = 454

 Score =  113 bits (283), Expect = 3e-25
 Identities = 85/301 (28%), Positives = 142/301 (47%), Gaps = 37/301 (12%)

Query: 41  LRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK-------TKLKN 93
           + T    DV  HYE+  ELG G +  V     KGTG + A KF+ K +          + 
Sbjct: 1   MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60

Query: 94  FLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKR 153
             REV+I   +   P II + D+ FE +   V   E    G+LFD +  +  L ED   +
Sbjct: 61  IEREVNILREIRH-PNIITLHDI-FENKTDVVLILELVSGGELFDFLAEKESLTEDEATQ 118

Query: 154 CVQQLGLALDFMHGRQLVHRDIKPENVLLFDREC--RRVKLADFGMTRRV--GCRVKRVS 209
            ++Q+   + ++H +++ H D+KPEN++L D+     R+KL DFG+  ++  G   K + 
Sbjct: 119 FLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIF 178

Query: 210 GTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPW------EAASGADAFF 263
           GT  + APE+      + L ++   D+W+ GV+ + +L+G  P+      E  +   A  
Sbjct: 179 GTPEFVAPEIV---NYEPLGLE--ADMWSIGVITYILLSGASPFLGETKQETLTNISAVN 233

Query: 264 EEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRR 323
            +F              +   +E A    +RLL  +P+RR     + + L+H     +RR
Sbjct: 234 YDFDE----------EYFSNTSELAKDFIRRLLVKDPKRR---MTIAQSLEHSWIKAIRR 280

Query: 324 R 324
           R
Sbjct: 281 R 281


>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
          Length = 486

 Score =  113 bits (283), Expect = 3e-25
 Identities = 87/337 (25%), Positives = 155/337 (45%), Gaps = 46/337 (13%)

Query: 2   SVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTED-----------------------MQA 38
           S G P P   R      P   P P AG P   +                        M A
Sbjct: 15  SPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSA 74

Query: 39  LTLRTLAASDVTK----HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKS----KTK 90
            T R     D       H++++R +GKG++GKV +V  + T    A+K++NK     + +
Sbjct: 75  ATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDE 134

Query: 91  LKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDT 150
           ++N  RE+ I   +    F++ ++    + ED ++   +    GDL   +   V   EDT
Sbjct: 135 VRNVFRELEILQEIEHV-FLVNLWYSFQDEEDMFMVV-DLLLGGDLRYHLQQNVQFSEDT 192

Query: 151 VKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRV--GCRVKRV 208
           V+  + ++ LALD++ G+ ++HRD+KP+N+LL +R      L DF +   +  G R   +
Sbjct: 193 VRLYICEMALALDYLRGQHIIHRDVKPDNILLDER--GHAHLTDFNIATIIKDGERATAL 250

Query: 209 SGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWE--AASGADAFFEEF 266
           +GT PY APE+  +    G      VD W+ GV+ + +L G  P++  +++  ++  + F
Sbjct: 251 AGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLF 310

Query: 267 VRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERR 303
                  +P        +++  + + ++LL + PE R
Sbjct: 311 STVSVQYVP-------TWSKEMVALLRKLLTVNPEHR 340


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  113 bits (282), Expect = 4e-25
 Identities = 84/263 (31%), Positives = 139/263 (52%), Gaps = 24/263 (9%)

Query: 6   PEPEPPR----SLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVT--KHYELVREL 59
           P  + PR    SL   GPG+ P   +   +L E   ++T    A S+     H+EL++ L
Sbjct: 20  PRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEI--SITHHVKAGSEKADPSHFELLKVL 77

Query: 60  GKGTYGKVDLV---VYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLS--SSPFIIKVF 114
           G+G++GKV LV       +G   A+K + K+  K+++ +R     + L+  + PF++K+ 
Sbjct: 78  GQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLH 137

Query: 115 DVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRD 174
              F+TE       ++   GDLF  +  +V   E+ VK  + +L L LD +H   +++RD
Sbjct: 138 -YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRD 196

Query: 175 IKPENVLLFDRECRRVKLADFGMTRRVGCRVKRV---SGTIPYTAPEVCQAGRADGLAVD 231
           +KPEN+LL D E   +KL DFG+++      K+     GT+ Y APEV      +     
Sbjct: 197 LKPENILL-DEE-GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV-----VNRQGHS 249

Query: 232 TGVDVWAFGVLIFCVLTGNFPWE 254
              D W++GVL+F +LTG+ P++
Sbjct: 250 HSADWWSYGVLMFEMLTGSLPFQ 272



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 80/297 (26%), Positives = 137/297 (46%), Gaps = 25/297 (8%)

Query: 36  MQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFL 95
           +Q L  + L  SD    Y +   +G G+Y +    V+K T  + A+K ++KSK   ++  
Sbjct: 413 VQQLHGKNLVFSD---GYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK---RDPS 466

Query: 96  REVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCV 155
            E+ I       P II + DV  + +  Y+   E    G+L D I  Q    E      +
Sbjct: 467 EEIEILLRYGQHPNIITLKDVYDDGKHVYLVT-ELMRGGELLDKILRQKFFSEREASFVL 525

Query: 156 QQLGLALDFMHGRQLVHRDIKPENVLLFDR----ECRRVKLADFGMTRRVGCR---VKRV 208
             +G  ++++H + +VHRD+KP N+L  D     EC R+   DFG  +++      +   
Sbjct: 526 HTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRI--CDFGFAKQLRAENGLLMTP 583

Query: 209 SGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVR 268
             T  + APEV +         D G D+W+ G+L++ +L G  P+ A   +D   E   R
Sbjct: 584 CYTANFVAPEVLKR-----QGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTR 637

Query: 269 WQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRP 325
              G+       W   +E A  +  ++L ++P +R  AK+V   L+H   ++  + P
Sbjct: 638 IGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQV---LQHPWVTQKDKLP 691


>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
          Length = 396

 Score =  113 bits (282), Expect = 4e-25
 Identities = 74/258 (28%), Positives = 137/258 (53%), Gaps = 17/258 (6%)

Query: 52  HYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK----TKLKNFLREVSITNSLSSS 107
           H+E++R +GKG++GKV +V    T    A+K++NK K     +++N  +E+ I   L   
Sbjct: 22  HFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEH- 80

Query: 108 PFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHG 167
           PF++ ++    + ED ++   +    GDL   +   V   E+TVK  + +L +ALD++  
Sbjct: 81  PFLVNLWYSFQDEEDMFMVV-DLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQN 139

Query: 168 RQLVHRDIKPENVLLFDRECRRVKLADFGMTRRV--GCRVKRVSGTIPYTAPEVCQAGRA 225
           ++++HRD+KP+N+LL   E   V + DF +   +    ++  ++GT PY APE+  + + 
Sbjct: 140 QRIIHRDMKPDNILL--DEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKG 197

Query: 226 DGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFT 285
            G +    VD W+ GV  + +L G  P+   S   +  +E V      +   PS W   +
Sbjct: 198 AGYSF--AVDWWSLGVTAYELLRGRRPYHIRSSTSS--KEIVHTFETTVVTYPSAW---S 250

Query: 286 EPALRMFQRLLALEPERR 303
           +  + + ++LL   P++R
Sbjct: 251 QEMVSLLKKLLEPNPDQR 268


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  112 bits (281), Expect = 5e-25
 Identities = 86/268 (32%), Positives = 140/268 (52%), Gaps = 28/268 (10%)

Query: 51  KH-YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTK----LKNFLREVSITNSLS 105
           KH YEL   LGKGTYGKV     + +G  +A+K + K K K    + +  RE+ I +SL+
Sbjct: 52  KHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLN 111

Query: 106 SSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFM 165
             P II +++V FE +D  V   EYA  G+L+D I  +  L E   +   +Q+  A+ + 
Sbjct: 112 H-PHIISIYEV-FENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYC 169

Query: 166 HGRQLVHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAG 223
           H   +VHRD+K EN+LL D  C  +K+ADFG++   +    ++   G+  Y +PE+    
Sbjct: 170 HKNGVVHRDLKLENILL-DDNC-NIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGR 227

Query: 224 RADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRR 283
              G  VD+    WA GVL++ ++ G  P+      D F  + +  Q         ++R 
Sbjct: 228 PYRGPEVDS----WALGVLLYTLVYGTMPF------DGFDHKNLIRQIS-----SGEYRE 272

Query: 284 FTEP--ALRMFQRLLALEPERRGPAKEV 309
            T+P  A  + + +L + P+RR   +++
Sbjct: 273 PTQPSDARGLIRWMLMVNPDRRATIEDI 300


>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
          Length = 414

 Score =  112 bits (280), Expect = 6e-25
 Identities = 96/325 (29%), Positives = 158/325 (48%), Gaps = 29/325 (8%)

Query: 18  GPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELV--RELGKGTYGKVDLVVYKGT 75
           GP   P P     LLTE ++A+ +RT    D    Y L   RELG+G +  V   + K +
Sbjct: 29  GPCRPPPPPQARGLLTE-IRAV-VRTEPFQD---GYSLCPGRELGRGKFAVVRKCIKKDS 83

Query: 76  GTKMALKFVNKSKTKLK---NFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAP 132
           G + A KF+ K +         + E+++      +P++I + +V +ET    +   EYA 
Sbjct: 84  GKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEV-YETASEMILVLEYAA 142

Query: 133 AGDLFD--IIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLL-FDRECRR 189
            G++FD  +   +    E  V+R ++Q+   + F+H R +VH D+KP+N+LL  +     
Sbjct: 143 GGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGD 202

Query: 190 VKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVL 247
           +K+ DFG++R  +    ++ + GT  Y APE+          +    D+W+ GVL + +L
Sbjct: 203 IKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYD-----PISMATDMWSIGVLTYVML 257

Query: 248 TGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAK 307
           TG  P+    G D   E F+   +  L     ++   +E A+   + LL  +PE R  A+
Sbjct: 258 TGISPF---LGNDK-QETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAE 313

Query: 308 EVFRFLKHE-LTSELRRRPSHRARK 331
           E    LKH  LT    + PS R  K
Sbjct: 314 EC---LKHPWLTQSSIQEPSFRMEK 335


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  112 bits (279), Expect = 8e-25
 Identities = 77/256 (30%), Positives = 136/256 (53%), Gaps = 21/256 (8%)

Query: 53  YELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSK---TKLKNFLREVSITNSLSSSPF 109
           Y++ R LGKG +  V L  ++ T T++A+K ++K++   + L+   REV +   L+  P 
Sbjct: 27  YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNH-PH 85

Query: 110 IIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQ 169
           IIK++ V+ ET+D      E+A  G++FD +     L E+  ++   Q+  A+++ H   
Sbjct: 86  IIKLYQVM-ETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHH 144

Query: 170 LVHRDIKPENVLLFDRECRRVKLADFGMTR--RVGCRVKRVSGTIPYTAPEVCQAGRADG 227
           +VHRD+K EN+LL       +KLADFG     + G  +    G+ PY APEV +    +G
Sbjct: 145 IVHRDLKTENLLLDGN--MDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEG 202

Query: 228 LAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEP 287
                 +D+W+ GV+++ ++ G+ P++  +       + V   R R+P   SQ       
Sbjct: 203 ----PQLDIWSLGVVLYVLVCGSLPFDGPNLPT--LRQRVLEGRFRIPFFMSQ------D 250

Query: 288 ALRMFQRLLALEPERR 303
              + +R+L ++P RR
Sbjct: 251 CESLIRRMLVVDPARR 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.140    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,074,493
Number of Sequences: 37866
Number of extensions: 1355422
Number of successful extensions: 18362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 840
Number of HSP's that attempted gapping in prelim test: 8772
Number of HSP's gapped (non-prelim): 5885
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.