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Search of human proteins with 65506745
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65506745 neurotrophic tyrosine kinase, receptor, type 2
isoform c precursor [Homo sapiens]
(822 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 1706 0.0
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 1696 0.0
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo... 1100 0.0
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo... 1089 0.0
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo... 975 0.0
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 868 0.0
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 858 0.0
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 719 0.0
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 719 0.0
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 707 0.0
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo... 366 e-101
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 290 5e-78
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 254 3e-67
gi|62420886 discoidin domain receptor family, member 2 precursor... 253 4e-67
gi|62420884 discoidin domain receptor family, member 2 precursor... 253 4e-67
gi|38327632 discoidin domain receptor family, member 1 isoform b... 247 3e-65
gi|83977450 discoidin domain receptor family, member 1 isoform a... 247 3e-65
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 246 6e-65
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 245 1e-64
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 244 2e-64
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 244 2e-64
gi|83977452 discoidin domain receptor family, member 1 isoform c... 241 3e-63
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 238 2e-62
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 231 2e-60
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 230 5e-60
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 225 1e-58
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 225 1e-58
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 218 2e-56
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 218 2e-56
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 217 4e-56
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 1706 bits (4419), Expect = 0.0
Identities = 822/822 (100%), Positives = 822/822 (100%)
Query: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
Query: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP 480
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP 480
Query: 481 LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL 540
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
Sbjct: 481 LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL 540
Query: 541 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI 600
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
Sbjct: 541 KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI 600
Query: 601 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 660
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
Sbjct: 601 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI 660
Query: 661 AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 720
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
Sbjct: 661 AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 720
Query: 721 PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ 780
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
Sbjct: 721 PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ 780
Query: 781 EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Sbjct: 781 EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 1696 bits (4392), Expect = 0.0
Identities = 822/838 (98%), Positives = 822/838 (98%), Gaps = 16/838 (1%)
Query: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
Query: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK--------------- 465
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
Query: 466 -GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 524
GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
Query: 525 KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 584
KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD
Sbjct: 541 KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 600
Query: 585 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 644
FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP
Sbjct: 601 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 660
Query: 645 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 704
PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST
Sbjct: 661 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720
Query: 705 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 764
DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE
Sbjct: 721 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780
Query: 765 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Sbjct: 781 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838
>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
e precursor [Homo sapiens]
Length = 537
Score = 1100 bits (2844), Expect = 0.0
Identities = 528/529 (99%), Positives = 529/529 (100%)
Query: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
Query: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP 480
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP 480
Query: 481 LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTF 529
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDT+
Sbjct: 481 LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTW 529
>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
d precursor [Homo sapiens]
Length = 553
Score = 1089 bits (2817), Expect = 0.0
Identities = 528/545 (96%), Positives = 529/545 (97%), Gaps = 16/545 (2%)
Query: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
Query: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK--------------- 465
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
Query: 466 -GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 524
GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
Query: 525 KPDTF 529
KPDT+
Sbjct: 541 KPDTW 545
>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
b precursor [Homo sapiens]
Length = 477
Score = 975 bits (2520), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
Query: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61 NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKG 466
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKG
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKG 466
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 868 bits (2243), Expect = 0.0
Identities = 464/849 (54%), Positives = 573/849 (67%), Gaps = 66/849 (7%)
Query: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
Query: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
Query: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
Query: 517 FGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 576
F ++ KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL P +DK+LVAVK LKD
Sbjct: 517 FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576
Query: 577 ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
+ ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYMKHGDLNKFLRAHGPDA
Sbjct: 577 PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
Query: 637 VLMAEGNPPT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIG 693
+++ +G P EL SQMLHIA QIA+GMVYLASQHFVHRDLATRNCLVG NLLVKIG
Sbjct: 637 MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696
Query: 694 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP 753
DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS GV+LWEIFTYGKQP
Sbjct: 697 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
Query: 754 WYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKA 813
W+QLSN EVIECITQGRVL+RPR CP+EVY++MLGCWQREP R NIK I+ +L L KA
Sbjct: 757 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKA 816
Query: 814 SPVYLDILG 822
+P+YLDILG
Sbjct: 817 TPIYLDILG 825
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 858 bits (2218), Expect = 0.0
Identities = 464/863 (53%), Positives = 573/863 (66%), Gaps = 80/863 (9%)
Query: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
Query: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
Query: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
Query: 517 FGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 576
F ++ KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL P +DK+LVAVK LKD
Sbjct: 517 FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576
Query: 577 ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
+ ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYMKHGDLNKFLRAHGPDA
Sbjct: 577 PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
Query: 637 VLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIG 693
+++ +G P EL SQMLHIA QIA+GMVYLASQHFVHRDLATRNCLVG NLLVKIG
Sbjct: 637 MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696
Query: 694 DFGMSRDVYSTDYYR--------------VGGHTMLPIRWMPPESIMYRKFTTESDVWSL 739
DFGMSRDVYSTDYYR VGGHTMLPIRWMPPESIMYRKFTTESDVWS
Sbjct: 697 DFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSF 756
Query: 740 GVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 799
GV+LWEIFTYGKQPW+QLSN EVIECITQGRVL+RPR CP+EVY++MLGCWQREP R N
Sbjct: 757 GVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLN 816
Query: 800 IKGIHTLLQNLAKASPVYLDILG 822
IK I+ +L L KA+P+YLDILG
Sbjct: 817 IKEIYKILHALGKATPIYLDILG 839
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 719 bits (1855), Expect = 0.0
Identities = 405/827 (48%), Positives = 520/827 (62%), Gaps = 59/827 (7%)
Query: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
Query: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
Query: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
Query: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
Query: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
Query: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
Query: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
+YTL+A N +G+ I A FM D+ N D I + T+ GD + +E
Sbjct: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408
Query: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDS 477
P V+ G L+V+A + ++++ +L L K R +KFG+ PA V++ +D
Sbjct: 409 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFGINRPA-VLAPEDGL 456
Query: 478 ASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHN 537
A LH ++ G ++ S +EG + + +IENPQYF D V HIKR +
Sbjct: 457 AMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACVHHIKRRD 503
Query: 538 IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH 597
IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAELLT LQH
Sbjct: 504 IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQH 563
Query: 598 EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTELTQSQMLH 655
+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L Q+L
Sbjct: 564 QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 623
Query: 656 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 715
+A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYRVGG TML
Sbjct: 624 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 683
Query: 716 PIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 775
PIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQGR L+RP
Sbjct: 684 PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP 743
Query: 776 RTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
R CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 744 RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 790
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 719 bits (1855), Expect = 0.0
Identities = 404/827 (48%), Positives = 518/827 (62%), Gaps = 53/827 (6%)
Query: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
Query: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
Query: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
Query: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
Query: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
Query: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
Query: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
+YTL+A N +G+ I A FM P NP P + + GD + +E
Sbjct: 358 NYTLLAANPFGQASASIMAAFMDNPF---EFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414
Query: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDS 477
P V+ G L+V+A + ++++ +L L K R +KFG+ PA V++ +D
Sbjct: 415 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFGINRPA-VLAPEDGL 462
Query: 478 ASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHN 537
A LH ++ G ++ S +EG + + +IENPQYF D V HIKR +
Sbjct: 463 AMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACVHHIKRRD 509
Query: 538 IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH 597
IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAELLT LQH
Sbjct: 510 IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQH 569
Query: 598 EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTELTQSQMLH 655
+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L Q+L
Sbjct: 570 QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 629
Query: 656 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 715
+A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYRVGG TML
Sbjct: 630 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 689
Query: 716 PIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 775
PIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQGR L+RP
Sbjct: 690 PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP 749
Query: 776 RTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
R CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 750 RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 796
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 707 bits (1824), Expect = 0.0
Identities = 387/758 (51%), Positives = 494/758 (65%), Gaps = 46/758 (6%)
Query: 72 FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
+I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N + N L SLS
Sbjct: 42 YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101
Query: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESSKNIPLANLQ 190
K + L L EL+L GNP CSC + W++ +E Q L C + PLA++
Sbjct: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157
Query: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
+CG+P+ + PN +V+ G + L C V G + W + L S SL
Sbjct: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
Query: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
+T N++SD + K ++C AEN VG + SV + V F P L + HHWCIPF+V
Sbjct: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276
Query: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG+YTL+A N
Sbjct: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336
Query: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
+G+ I A FM D+ N D I + T+ GD + +E P V+
Sbjct: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETPF-GVSVAV 386
Query: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISN 486
G L+V+A + ++++ +L L K R +KFG+ PA V++ +D A LH ++
Sbjct: 387 G---LAVFACLFLSTL-------LLVLNKCGRRNKFGINRPA-VLAPEDGLAMSLHFMTL 435
Query: 487 GSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGE 546
G ++ S +EG + + +IENPQYF D V HIKR +IVLK ELGE
Sbjct: 436 GGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACVHHIKRRDIVLKWELGE 482
Query: 547 GAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGV 606
GAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAELLT LQH+HIV+F+GV
Sbjct: 483 GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGV 542
Query: 607 CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTELTQSQMLHIAQQIAAGM 664
C EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L Q+L +A Q+AAGM
Sbjct: 543 CTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGM 602
Query: 665 VYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPES 724
VYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYRVGG TMLPIRWMPPES
Sbjct: 603 VYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES 662
Query: 725 IMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYE 784
I+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQGR L+RPR CP EVY
Sbjct: 663 ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYA 722
Query: 785 LMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
+M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 723 IMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760
>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
c precursor [Homo sapiens]
Length = 612
Score = 366 bits (939), Expect = e-101
Identities = 223/564 (39%), Positives = 314/564 (55%), Gaps = 64/564 (11%)
Query: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
Query: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
Query: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
Query: 517 FGITNSQLKPDTFV-QHIKRHNIV 539
F ++ KPDT+V +I H I+
Sbjct: 517 FRQGHNCHKPDTWVFSNIDNHGIL 540
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 290 bits (741), Expect = 5e-78
Identities = 145/303 (47%), Positives = 197/303 (65%), Gaps = 16/303 (5%)
Query: 524 LKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNAR 582
L P R+NI R++GEGAFG+VF A L P + +VAVK LK+ AS + +
Sbjct: 561 LNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQ 620
Query: 583 KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV----- 637
DF REA L+ + +IVK GVC G P+ ++FEYM +GDLN+FLR+ P V
Sbjct: 621 ADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSH 680
Query: 638 --------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL 689
+ + G PP L+ ++ L IA+Q+AAGM YL+ + FVHRDLATRNCLVGEN++
Sbjct: 681 SDLSMRAQVSSPGPPP--LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV 738
Query: 690 VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY 749
VKI DFG+SR++YS DYY+ + +PIRWMPPESI Y ++TTESDVW+ GVVLWEIF+Y
Sbjct: 739 VKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSY 798
Query: 750 GKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 809
G QP+Y +++ EVI + G +L P CP E+Y LM CW + P R + IH +L+
Sbjct: 799 GLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILER 858
Query: 810 LAK 812
+ +
Sbjct: 859 MCE 861
Score = 51.6 bits (122), Expect = 3e-06
Identities = 50/172 (29%), Positives = 77/172 (44%), Gaps = 17/172 (9%)
Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQ 263
N+ + EG L C+ G+P P++ W G+ + + + + GSLRI N+ +D+G Q
Sbjct: 129 NVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAG-Q 187
Query: 264 ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPF-----TVKGNPKPALQWF 318
CVA+N +G V + + L +P S + F T G P P + W
Sbjct: 188 YRCVAKNSLGTAYSKV-VKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI 246
Query: 319 YNG-AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
NG A+ + S K V + LQL G YT IA N++G+
Sbjct: 247 ENGNAVSSGSIQESVKDRVIDSR-----LQL---FITKPGLYTCIATNKHGE 290
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/206 (26%), Positives = 82/206 (39%), Gaps = 34/206 (16%)
Query: 183 NIPLANL----------QIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV 232
NIPL ++ ++P + + L + VEE T C+V P P + W
Sbjct: 6 NIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEE--VATFMCAVESYPQPEISWTR 63
Query: 233 GNLVSKHMNET-SHTQGSLRITNISSDDSGKQI-SCVAENLVGEDQDSVN-LTVHFAPTI 289
++ K + S + +T +S +DS I C A N VG +S L V P I
Sbjct: 64 NKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKI 123
Query: 290 T-------FLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
T +E + +P T GNPKP++ W + L E+ I
Sbjct: 124 TRPPINVKIIEGLKA----VLPCTTMGNPKPSVSWIKGDSPLRENSRIAVL--------E 171
Query: 343 HGCLQLDNPTHMNNGDYTLIAKNEYG 368
G L++ N + G Y +AKN G
Sbjct: 172 SGSLRIHNVQKEDAGQYRCVAKNSLG 197
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 254 bits (648), Expect = 3e-67
Identities = 136/313 (43%), Positives = 187/313 (59%), Gaps = 14/313 (4%)
Query: 509 PVIENPQYFGITNSQL------KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCP 562
PV P++ N ++ KP + + + + ELGE AFGK++ Y P
Sbjct: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY--LP 495
Query: 563 EQDKI-LVAVKTLKDASDNAR-KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 620
D LVA+KTLKD ++ + +F +EA L+ L H +IV G + P+ M+FEY+
Sbjct: 496 GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYI 555
Query: 621 KHGDLNKFLRAHGPDAVLMA----EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRD 676
GDL++FL P + + +G + L LHIA QIAAGM YL+S FVH+D
Sbjct: 556 NQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKD 615
Query: 677 LATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 736
LA RN L+GE L VKI D G+SR++YS DYYRV ++LPIRWMPPE+IMY KF+++SD+
Sbjct: 616 LAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDI 675
Query: 737 WSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHM 796
WS GVVLWEIF++G QP+Y SN EVIE + + ++L CP +Y LM CW P
Sbjct: 676 WSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSR 735
Query: 797 RKNIKGIHTLLQN 809
R K IH L++
Sbjct: 736 RPRFKDIHVRLRS 748
Score = 35.8 bits (81), Expect = 0.17
Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 6/91 (6%)
Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNL----VSKHMNETSHTQGS-LRITNISSDD 259
N+T G++ L C V+G+P P + W + + ++ S GS LRI N+ + D
Sbjct: 66 NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125
Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTIT 290
+G CVA N + L V F P T
Sbjct: 126 TG-YFQCVATNGKEVVSSTGVLFVKFGPPPT 155
Score = 32.3 bits (72), Expect = 1.8
Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 8/94 (8%)
Query: 307 VKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
V GNP P ++WF N A ++ E + + + T Y L++ N + G + +A N
Sbjct: 81 VSGNPPPTIRWFKNDAPVVQEPRRLSFR-----STIYGSRLRIRNLDTTDTGYFQCVATN 135
Query: 366 EYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399
GK+ + G A+P Y D ED
Sbjct: 136 --GKEVVSSTGVLFVKFGPPPTASPGYSDEYEED 167
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 253 bits (647), Expect = 4e-67
Identities = 148/341 (43%), Positives = 204/341 (59%), Gaps = 27/341 (7%)
Query: 491 PSSSEGGP---DAVIIGMTKIPVIENPQYFGITNSQLK-PDTFVQHIKRHNIVLKRELGE 546
PS EG P +A I+ + + +T L D V+ R + K +LGE
Sbjct: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571
Query: 547 GAFGKVFLAECYNLCPEQDK-----------ILVAVKTLK-DASDNARKDFHREAELLTN 594
G FG+V L E + +DK +LVAVK L+ DA+ NAR DF +E ++++
Sbjct: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSR 631
Query: 595 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 654
L+ +I+ VC+ DPL M+ EYM++GDLN+FL H P + + ++ + +
Sbjct: 632 LKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN---SSSSDVRTVSYTNLK 688
Query: 655 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 714
+A QIA+GM YL+S +FVHRDLATRNCLVG+N +KI DFGMSR++YS DYYR+ G +
Sbjct: 689 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 748
Query: 715 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSNNEVIECI-----TQ 768
LPIRWM ESI+ KFTT SDVW+ GV LWE FT+ +QP+ QLS+ +VIE Q
Sbjct: 749 LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQ 808
Query: 769 GR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807
GR L +P CP VY+LML CW+R+ R + + IH LL
Sbjct: 809 GRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 253 bits (647), Expect = 4e-67
Identities = 148/341 (43%), Positives = 204/341 (59%), Gaps = 27/341 (7%)
Query: 491 PSSSEGGP---DAVIIGMTKIPVIENPQYFGITNSQLK-PDTFVQHIKRHNIVLKRELGE 546
PS EG P +A I+ + + +T L D V+ R + K +LGE
Sbjct: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571
Query: 547 GAFGKVFLAECYNLCPEQDK-----------ILVAVKTLK-DASDNARKDFHREAELLTN 594
G FG+V L E + +DK +LVAVK L+ DA+ NAR DF +E ++++
Sbjct: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSR 631
Query: 595 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 654
L+ +I+ VC+ DPL M+ EYM++GDLN+FL H P + + ++ + +
Sbjct: 632 LKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN---SSSSDVRTVSYTNLK 688
Query: 655 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 714
+A QIA+GM YL+S +FVHRDLATRNCLVG+N +KI DFGMSR++YS DYYR+ G +
Sbjct: 689 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 748
Query: 715 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSNNEVIECI-----TQ 768
LPIRWM ESI+ KFTT SDVW+ GV LWE FT+ +QP+ QLS+ +VIE Q
Sbjct: 749 LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQ 808
Query: 769 GR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807
GR L +P CP VY+LML CW+R+ R + + IH LL
Sbjct: 809 GRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 247 bits (631), Expect = 3e-65
Identities = 144/304 (47%), Positives = 189/304 (62%), Gaps = 36/304 (11%)
Query: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 579
R + K +LGEG FG+V L E + QD + LVAVK L+ DA+
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626
Query: 580 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 639
NAR DF +E ++++ L+ +I++ GVCV+ DPL M+ +YM++GDLN+FL AH +
Sbjct: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA- 685
Query: 640 AEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVK 691
AEG P PT ++ +LH+A QIA+GM YLA+ +FVHRDLATRNCLVGEN +K
Sbjct: 686 AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744
Query: 692 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 751
I DFGMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+ GV LWE+ +
Sbjct: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 804
Query: 752 -QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 803
QP+ QL++ +VIE QGR L RP CPQ +YELML CW RE R +
Sbjct: 805 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864
Query: 804 HTLL 807
H L
Sbjct: 865 HRFL 868
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 247 bits (631), Expect = 3e-65
Identities = 144/304 (47%), Positives = 189/304 (62%), Gaps = 36/304 (11%)
Query: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 579
R + K +LGEG FG+V L E + QD + LVAVK L+ DA+
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 663
Query: 580 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 639
NAR DF +E ++++ L+ +I++ GVCV+ DPL M+ +YM++GDLN+FL AH +
Sbjct: 664 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA- 722
Query: 640 AEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVK 691
AEG P PT ++ +LH+A QIA+GM YLA+ +FVHRDLATRNCLVGEN +K
Sbjct: 723 AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 781
Query: 692 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 751
I DFGMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+ GV LWE+ +
Sbjct: 782 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 841
Query: 752 -QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 803
QP+ QL++ +VIE QGR L RP CPQ +YELML CW RE R +
Sbjct: 842 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 901
Query: 804 HTLL 807
H L
Sbjct: 902 HRFL 905
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 246 bits (628), Expect = 6e-65
Identities = 125/270 (46%), Positives = 169/270 (62%), Gaps = 4/270 (1%)
Query: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAELLTNLQHEHIV 601
ELGE FGKV+ + P + VA+KTLKD ++ R++F EA L LQH ++V
Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
Query: 602 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT---ELTQSQMLHIAQ 658
GV + PL M+F Y HGDL++FL P + + + + T L +H+
Sbjct: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
Query: 659 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 718
QIAAGM YL+S H VH+DLATRN LV + L VKI D G+ R+VY+ DYY++ G+++LPIR
Sbjct: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
Query: 719 WMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC 778
WM PE+IMY KF+ +SD+WS GVVLWE+F+YG QP+ SN +V+E I +VL P C
Sbjct: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
Query: 779 PQEVYELMLGCWQREPHMRKNIKGIHTLLQ 808
P VY LM+ CW P R K IH+ L+
Sbjct: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLR 747
Score = 39.3 bits (90), Expect = 0.015
Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYW-----DVGNLVSKHMNETSHTQGSLRITNISSDD 259
N+T+ +G++ L C VAG+P PN+ W V + + + LRI ++ + D
Sbjct: 70 NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129
Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH---WCIPF 305
+G CVA N + + L V PT + + D+H +C P+
Sbjct: 130 TG-YYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPY 177
Score = 30.4 bits (67), Expect = 7.0
Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 12/112 (10%)
Query: 289 ITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQ 347
IT ++ T+ H V GNP P ++W N A ++ E + I + TEY L+
Sbjct: 71 ITIVQGQTAILHC----KVAGNPPPNVRWLKNDAPVVQEPRRI-----IIRKTEYGSRLR 121
Query: 348 LDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399
+ + + G Y +A N G + G N N+ D +ED
Sbjct: 122 IQDLDTTDTGYYQCVATN--GMKTITATGVLFVRLGPTHSPNHNFQDDYHED 171
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 245 bits (626), Expect = 1e-64
Identities = 127/289 (43%), Positives = 178/289 (61%), Gaps = 13/289 (4%)
Query: 513 NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 572
NP+YF + + PD + + R I + RELG+G+FG V+ + ++ + VA+K
Sbjct: 977 NPEYFSAADVYV-PDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033
Query: 573 TLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 631
T+ +A+ R +F EA ++ H+V+ GV +G P +++ E M GDL +LR+
Sbjct: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093
Query: 632 HGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL 688
P+ E NP P L S+M+ +A +IA GM YL + FVHRDLA RNC+V E+
Sbjct: 1094 LRPEM----ENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147
Query: 689 LVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 748
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SDVWS GVVLWEI T
Sbjct: 1148 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 1207
Query: 749 YGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 797
+QP+ LSN +V+ + +G +L +P CP ++ELM CWQ P MR
Sbjct: 1208 LAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMR 1256
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 244 bits (624), Expect = 2e-64
Identities = 131/302 (43%), Positives = 182/302 (60%), Gaps = 10/302 (3%)
Query: 513 NPQYFGITN----SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKIL 568
NP+Y ++ S PD + + R I L RELG+G+FG V+ ++ + +
Sbjct: 984 NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
Query: 569 VAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNK 627
VAVKT+ + AS R +F EA ++ H+V+ GV +G P ++V E M HGDL
Sbjct: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
Query: 628 FLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN 687
+LR+ P+A G PP L +M+ +A +IA GM YL ++ FVHRDLA RNC+V +
Sbjct: 1102 YLRSLRPEAE-NNPGRPPPTL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
Query: 688 LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 747
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SD+WS GVVLWEI
Sbjct: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
Query: 748 TYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807
+ +QP+ LSN +V++ + G L +P CP+ V +LM CWQ P MR I LL
Sbjct: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
Query: 808 QN 809
++
Sbjct: 1279 KD 1280
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 244 bits (624), Expect = 2e-64
Identities = 131/302 (43%), Positives = 182/302 (60%), Gaps = 10/302 (3%)
Query: 513 NPQYFGITN----SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKIL 568
NP+Y ++ S PD + + R I L RELG+G+FG V+ ++ + +
Sbjct: 996 NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1053
Query: 569 VAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNK 627
VAVKT+ + AS R +F EA ++ H+V+ GV +G P ++V E M HGDL
Sbjct: 1054 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1113
Query: 628 FLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN 687
+LR+ P+A G PP L +M+ +A +IA GM YL ++ FVHRDLA RNC+V +
Sbjct: 1114 YLRSLRPEAE-NNPGRPPPTL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1170
Query: 688 LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 747
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SD+WS GVVLWEI
Sbjct: 1171 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1230
Query: 748 TYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807
+ +QP+ LSN +V++ + G L +P CP+ V +LM CWQ P MR I LL
Sbjct: 1231 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
Query: 808 QN 809
++
Sbjct: 1291 KD 1292
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 241 bits (614), Expect = 3e-63
Identities = 144/310 (46%), Positives = 189/310 (60%), Gaps = 42/310 (13%)
Query: 535 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 579
R + K +LGEG FG+V L E + QD + LVAVK L+ DA+
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 663
Query: 580 NA------RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHG 633
NA R DF +E ++++ L+ +I++ GVCV+ DPL M+ +YM++GDLN+FL AH
Sbjct: 664 NASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 723
Query: 634 PDAVLMAEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG 685
+ AEG P PT ++ +LH+A QIA+GM YLA+ +FVHRDLATRNCLVG
Sbjct: 724 LEDKA-AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG 781
Query: 686 ENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE 745
EN +KI DFGMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+ GV LWE
Sbjct: 782 ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWE 841
Query: 746 IFTYGK-QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMR 797
+ + QP+ QL++ +VIE QGR L RP CPQ +YELML CW RE R
Sbjct: 842 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 901
Query: 798 KNIKGIHTLL 807
+H L
Sbjct: 902 PPFSQLHRFL 911
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 238 bits (607), Expect = 2e-62
Identities = 129/304 (42%), Positives = 183/304 (60%), Gaps = 9/304 (2%)
Query: 513 NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 572
NP+YF ++ + PD + + R I + RELG+G+FG V+ L ++ VA+K
Sbjct: 957 NPEYFSASDMYV-PDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013
Query: 573 TLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 631
T+ + AS +F +EA ++ + H+V+ GV +G P +++ E M GDL LR+
Sbjct: 1014 TVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRS 1073
Query: 632 HGPDAVLMAEGNPPT-ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 690
P+A E NP + +M+ +A +IA GM YLA+ FVHRDLA RNC+V ++ V
Sbjct: 1074 LRPEA----ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTV 1129
Query: 691 KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG 750
KIGDFGM+RDVY TDYYR GG +LP+RWM PES+ FTT SDVWS GVVLWEI T
Sbjct: 1130 KIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLA 1189
Query: 751 KQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 810
+QP+ LSN +V++ + G VL+ CP ++ ELM CWQ P +R + I +Q
Sbjct: 1190 EQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEE 1249
Query: 811 AKAS 814
+ S
Sbjct: 1250 LRPS 1253
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 231 bits (589), Expect = 2e-60
Identities = 116/274 (42%), Positives = 163/274 (59%), Gaps = 10/274 (3%)
Query: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA-SDNARKDFHRE 588
++ + R NI L R LG GAFG+V+ + + + + VAVKTL + S+ DF E
Sbjct: 1108 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME 1167
Query: 589 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 648
A +++ H++IV+ GV ++ P ++ E M GDL FLR P + P+ L
Sbjct: 1168 ALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP------RPSQPSSL 1221
Query: 649 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 705
+LH+A+ IA G YL HF+HRD+A RNCL+ G + KIGDFGM+RD+Y
Sbjct: 1222 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 1281
Query: 706 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 765
YYR GG MLP++WMPPE+ M FT+++D WS GV+LWEIF+ G P+ SN EV+E
Sbjct: 1282 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF 1341
Query: 766 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 799
+T G + P+ CP VY +M CWQ +P R N
Sbjct: 1342 VTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN 1375
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 230 bits (586), Expect = 5e-60
Identities = 178/615 (28%), Positives = 283/615 (46%), Gaps = 74/615 (12%)
Query: 204 PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
P +E K T+ CS G P + W+ + S T + G+L ++ DD+G
Sbjct: 510 PQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNA-GTLHFARVTRDDAGNY 568
Query: 264 ISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHWCIPFTVKGNPKPALQW 317
+C+A N G+ + V LTV A ITF P H + +G+PKP +QW
Sbjct: 569 -TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625
Query: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
IL+ TK+ H +G L + + ++G YT IA N + +
Sbjct: 626 KGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLY 680
Query: 378 FMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVV 437
+ P ++ P P Y+ T +G AV
Sbjct: 681 VVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA-------------------------AVA 714
Query: 438 VIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGS---NTPSSS 494
I +V+G ++F K +K K P + P NG N S+
Sbjct: 715 YIIAVLG-----LMFYCKKRCKAKRLQKQP--------EGEEPEMECLNGGPLQNGQPSA 761
Query: 495 EGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFL 554
E + + + P N ++ T+ ++ H R ++ LG+ FG+VFL
Sbjct: 762 EIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSLQPITTLGKSEFGEVFL 812
Query: 555 AECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLI 614
A+ L + LV VK+L+ + + DF RE E+ L H ++V+ G+C E +P
Sbjct: 813 AKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHY 872
Query: 615 MVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFV 673
MV EY+ GDL +FLR + D L ++ L+ Q + + Q+A GM +L++ FV
Sbjct: 873 MVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALCTQVALGMEHLSNNRFV 927
Query: 674 HRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE 733
H+DLA RNCLV VK+ G+S+DVY+++YY +P+RWM PE+I+ F+T+
Sbjct: 928 HKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTK 986
Query: 734 SDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCPQEVYELMLGCWQR 792
SDVW+ GV++WE+FT+G+ P +++EV+ + G+ L +P CP ++Y LM CW
Sbjct: 987 SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 1046
Query: 793 EPHMRKNIKGIHTLL 807
P R + I + L
Sbjct: 1047 SPKDRPSFSEIASAL 1061
Score = 37.4 bits (85), Expect = 0.057
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
+G+ L C V ++YW + + SL + CVA
Sbjct: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
Query: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
Query: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
Score = 33.5 bits (75), Expect = 0.82
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
Query: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
Query: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 225 bits (574), Expect = 1e-58
Identities = 180/645 (27%), Positives = 295/645 (45%), Gaps = 73/645 (11%)
Query: 206 LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-----HTQGSLRITNISSDDS 260
L V ++ C AG+P P++ W + + H Q SL + ++ D
Sbjct: 164 LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223
Query: 261 GKQISCVAENLVGEDQDSVNLTV-HFAPTITFLESPTSDHHWCIPFT-------VKGNPK 312
G +CV EN G + + L V +P L++ + + + V + +
Sbjct: 224 GNY-TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQ 282
Query: 313 PALQWFYNGAILNESK-------YICT-KIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAK 364
P +QW + + N SK Y+ K ++ E L+L N + + G+Y A
Sbjct: 283 PHIQWLKHVEV-NGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRAT 341
Query: 365 NEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTD 424
N G EK W + +G A + E+ D
Sbjct: 342 NFIGVAEKAF------WLSV---------------HGPRAAE--------EELVEAD--- 369
Query: 425 KTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHI 484
E SVYA ++ V F ++++ + L R KG S + +
Sbjct: 370 ----EAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 425
Query: 485 SNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKREL 544
S SN SS + ++ + ++ E P ++ +L D + + R + L + L
Sbjct: 426 SLESNASMSS----NTPLVRIARLSSGEGPTLANVSELELPADPKWE-LSRARLTLGKPL 480
Query: 545 GEGAFGKVFLAECYNLCPEQ--DKILVAVKTLKD-ASDNARKDFHREAELLTNL-QHEHI 600
GEG FG+V +AE + ++ + VAVK LKD A+D D E E++ + +H++I
Sbjct: 481 GEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNI 540
Query: 601 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGN---PPTELTQSQMLHIA 657
+ G C +G PL ++ EY G+L +FLRA P + + P +LT ++ A
Sbjct: 541 INLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCA 600
Query: 658 QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 717
Q+A GM YLASQ +HRDLA RN LV E+ ++KI DFG++RDV++ DYY+ + LP+
Sbjct: 601 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPV 660
Query: 718 RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT 777
+WM PE++ R +T +SDVWS GV+LWEIFT G P+ + E+ + + +G + +P
Sbjct: 661 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN 720
Query: 778 CPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL--AKASPVYLDI 820
C ++Y +M CW P R K + L + ++ YLD+
Sbjct: 721 CTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDL 765
Score = 34.3 bits (77), Expect = 0.48
Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 23/110 (20%)
Query: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW---------DVG-------N 234
I GLP+ N T G + C V D P++ W VG
Sbjct: 254 ILQAGLPA------NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT 307
Query: 235 LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVH 284
++ ++E+ LR+ N+S D G+ + C A N +G + + L+VH
Sbjct: 308 VLKSWISESVEADVRLRLANVSERDGGEYL-CRATNFIGVAEKAFWLSVH 356
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 225 bits (573), Expect = 1e-58
Identities = 180/646 (27%), Positives = 295/646 (45%), Gaps = 77/646 (11%)
Query: 206 LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-----HTQGSLRITNISSDDS 260
L V ++ C AG+P P++ W + + H Q SL + ++ D
Sbjct: 164 LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223
Query: 261 GKQISCVAENLVGEDQDSVNLTV-HFAPTITFLESPTSDHHWCIPFT-------VKGNPK 312
G +CV EN G + + L V +P L++ + + + V + +
Sbjct: 224 GNY-TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQ 282
Query: 313 PALQWFYNGAILNESK-------YICT-KIHVTNHTEYH-GCLQLDNPTHMNNGDYTLIA 363
P +QW + + N SK Y+ K N T+ L L N T + G+YT +A
Sbjct: 283 PHIQWLKHVEV-NGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLA 341
Query: 364 KNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVT 423
N G +H W + + E+ A++ G
Sbjct: 342 GNSIG------FSHHSAWLVV----------LPAEEELVEADEAG--------------- 370
Query: 424 DKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHH 483
SVYA ++ V F ++++ + L R KG S +
Sbjct: 371 --------SVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQ 422
Query: 484 ISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRE 543
+S SN SS + ++ + ++ E P ++ +L D + + R + L +
Sbjct: 423 VSLESNASMSS----NTPLVRIARLSSGEGPTLANVSELELPADPKWE-LSRARLTLGKP 477
Query: 544 LGEGAFGKVFLAECYNLCPEQ--DKILVAVKTLKD-ASDNARKDFHREAELLTNL-QHEH 599
LGEG FG+V +AE + ++ + VAVK LKD A+D D E E++ + +H++
Sbjct: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
Query: 600 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGN---PPTELTQSQMLHI 656
I+ G C +G PL ++ EY G+L +FLRA P + + P +LT ++
Sbjct: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
Query: 657 AQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 716
A Q+A GM YLASQ +HRDLA RN LV E+ ++KI DFG++RDV++ DYY+ + LP
Sbjct: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
Query: 717 IRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPR 776
++WM PE++ R +T +SDVWS GV+LWEIFT G P+ + E+ + + +G + +P
Sbjct: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
Query: 777 TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL--AKASPVYLDI 820
C ++Y +M CW P R K + L + ++ YLD+
Sbjct: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDL 763
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 218 bits (554), Expect = 2e-56
Identities = 111/283 (39%), Positives = 161/283 (56%), Gaps = 10/283 (3%)
Query: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHRE 588
V + N+ L R LG GAFG+V+ L + + VA+KTL + S DF E
Sbjct: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
Query: 589 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 648
A +++ +H++IV+ G+ + P +++ E M GD+ FLR P P+ L
Sbjct: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPL 615
Query: 649 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 705
+L +AQ IA G YL HF+HRD+A RNCL+ G + + KIGDFGM+RD+Y
Sbjct: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675
Query: 706 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 765
YYR G +LP++WMPPE+ + FT+++D WS GV+LWEIF+ G P+ +N EV++
Sbjct: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735
Query: 766 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 808
+ G + PR CP VY +M CWQ EP +R + I LQ
Sbjct: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 218 bits (554), Expect = 2e-56
Identities = 111/283 (39%), Positives = 161/283 (56%), Gaps = 10/283 (3%)
Query: 530 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHRE 588
V + N+ L R LG GAFG+V+ L + + VA+KTL + S DF E
Sbjct: 441 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 500
Query: 589 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 648
A +++ +H++IV+ G+ + P +++ E M GD+ FLR P P+ L
Sbjct: 501 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPL 554
Query: 649 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 705
+L +AQ IA G YL HF+HRD+A RNCL+ G + + KIGDFGM+RD+Y
Sbjct: 555 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 614
Query: 706 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 765
YYR G +LP++WMPPE+ + FT+++D WS GV+LWEIF+ G P+ +N EV++
Sbjct: 615 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 674
Query: 766 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 808
+ G + PR CP VY +M CWQ EP +R + I LQ
Sbjct: 675 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 717
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 217 bits (552), Expect = 4e-56
Identities = 141/401 (35%), Positives = 199/401 (49%), Gaps = 37/401 (9%)
Query: 438 VIASVVGFCLLVMLFLLKLARHS--KFGMKGP---ASVISNDDDSASPLHHISNGSNTPS 492
VIA+ V F +V + L H KF K P A + A P+ + S+G+ PS
Sbjct: 637 VIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPS 696
Query: 493 SSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKV 552
+ + ++E+P++ R N+VL + LGEG FGKV
Sbjct: 697 LDSMENQ---VSVDAFKILEDPKW---------------EFPRKNLVLGKTLGEGEFGKV 738
Query: 553 FLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGD 611
A ++L VAVK LK+ AS + +D E +L + H H++K YG C +
Sbjct: 739 VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG 798
Query: 612 PLIMVFEYMKHGDLNKFLRAH---GPDAVLMAEGNP-------PTE--LTQSQMLHIAQQ 659
PL+++ EY K+G L FLR GP L + G+ P E LT ++ A Q
Sbjct: 799 PLLLIVEYAKYGSLRGFLRESRKVGP-GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ 857
Query: 660 IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRW 719
I+ GM YLA VHRDLA RN LV E +KI DFG+SRDVY D Y +P++W
Sbjct: 858 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKW 917
Query: 720 MPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCP 779
M ES+ +TT+SDVWS GV+LWEI T G P+ + + + G ++RP C
Sbjct: 918 MAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS 977
Query: 780 QEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDI 820
+E+Y LML CW++EP R I L+ + YLD+
Sbjct: 978 EEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDL 1018
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,496,922
Number of Sequences: 37866
Number of extensions: 1544990
Number of successful extensions: 7942
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 601
Number of HSP's successfully gapped in prelim test: 447
Number of HSP's that attempted gapping in prelim test: 3713
Number of HSP's gapped (non-prelim): 2619
length of query: 822
length of database: 18,247,518
effective HSP length: 111
effective length of query: 711
effective length of database: 14,044,392
effective search space: 9985562712
effective search space used: 9985562712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.