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Search of human proteins with 64085121
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
(764 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 1548 0.0
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 682 0.0
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 630 e-180
gi|217330610 thyroid stimulating hormone receptor isoform 3 prec... 470 e-132
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 469 e-132
gi|64085161 thyroid stimulating hormone receptor isoform 2 precu... 469 e-132
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 190 5e-48
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 180 4e-45
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 151 2e-36
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 151 2e-36
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 146 8e-35
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 143 5e-34
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 131 2e-30
gi|4557859 somatostatin receptor 2 [Homo sapiens] 76 1e-13
gi|4557857 somatostatin receptor 1 [Homo sapiens] 72 1e-12
gi|30023826 G-protein coupled purinergic receptor P2Y8 [Homo sap... 72 2e-12
gi|161484640 neuromedin B receptor [Homo sapiens] 72 2e-12
gi|4826706 EBV-induced G protein-coupled receptor 2 [Homo sapiens] 72 3e-12
gi|5174593 melatonin receptor 1A [Homo sapiens] 70 1e-11
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 69 1e-11
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 69 2e-11
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 69 2e-11
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 69 2e-11
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 69 2e-11
gi|7669548 tachykinin receptor 3 [Homo sapiens] 69 2e-11
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 68 4e-11
gi|215272321 chemokine-like receptor 1 isoform a [Homo sapiens] 67 6e-11
gi|215272319 chemokine-like receptor 1 isoform a [Homo sapiens] 67 6e-11
gi|215272317 chemokine-like receptor 1 isoform a [Homo sapiens] 67 6e-11
gi|4758014 chemokine-like receptor 1 isoform b [Homo sapiens] 67 6e-11
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 1548 bits (4007), Expect = 0.0
Identities = 764/764 (100%), Positives = 764/764 (100%)
Query: 1 MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI 60
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
Sbjct: 1 MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI 60
Query: 61 ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD 120
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
Sbjct: 61 ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD 120
Query: 121 ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL 180
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
Sbjct: 121 ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL 180
Query: 181 TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA 240
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA
Sbjct: 181 TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA 240
Query: 241 LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM 300
LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM
Sbjct: 241 LPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLM 300
Query: 301 CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE 360
CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE
Sbjct: 301 CNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQE 360
Query: 361 DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV 420
DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV
Sbjct: 361 DEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIV 420
Query: 421 VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE 480
VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE
Sbjct: 421 VWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSE 480
Query: 481 YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA 540
YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA
Sbjct: 481 YYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACA 540
Query: 541 IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC 600
IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC
Sbjct: 541 IMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCC 600
Query: 601 YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK 660
YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK
Sbjct: 601 YVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSK 660
Query: 661 ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ 720
ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ
Sbjct: 661 ILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQ 720
Query: 721 VQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL 764
VQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
Sbjct: 721 VQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL 764
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 682 bits (1760), Expect = 0.0
Identities = 364/704 (51%), Positives = 470/704 (66%), Gaps = 63/704 (8%)
Query: 6 LLQLVLLLD--LPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETH 63
LL+L+LLL LPR L C P C C + R P L L
Sbjct: 10 LLKLLLLLQPPLPRALREALCPEP-CNCVPDGALRC--------PGPTAGLTRLSLAYLP 60
Query: 64 LRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALK 123
++ IPS AF L + +I +S +L+++E+++F NL ++ I I+NT+NL YI+P A
Sbjct: 61 VKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFI 120
Query: 124 ELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLK 183
LP LK+L I NTG++ FPD+TKV+S++ FILEI DN ++T+IP NAFQG+ NE++TLK
Sbjct: 121 NLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLK 180
Query: 184 LYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPS 243
LY NGF VQ +AFNGT L ++ L +N +L + AF G +GP LD+S T + ALPS
Sbjct: 181 LYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGA-TGPKTLDISSTKLQALPS 239
Query: 244 KGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNE 303
GLE ++ LIA ++++LKKLP +F++L A L+YPSHCCAF+N L E
Sbjct: 240 YGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRN----------LPTKE 289
Query: 304 SSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEI 363
Q + ++ ++ E S + +N Y E E
Sbjct: 290 --------------------QNFSHSISENFSKQCE-STVRKVNNKTLYSSMLAESE--- 325
Query: 364 IGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWF 423
L +D Y+Y C C P+ D FNPCEDIMGY FLR+++W
Sbjct: 326 --------------LSGWD--YEYGFCLPKTPR-CAPEPDAFNPCEDIMGYDFLRVLIWL 368
Query: 424 VSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYN 483
+++LA++GN+ VL +LLTS YKL VPRFLMCNL+FADFCMG+YLLLIASVD T +YYN
Sbjct: 369 INILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYN 428
Query: 484 HAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMV 543
HAIDWQTG GC+TAGFFTVFASELSVYTLTVITLERW+ IT+A+ LD+K+RLRHA IM+
Sbjct: 429 HAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIML 488
Query: 544 GGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVK 603
GGW+ L+A+LPLVG+S+Y KVSIC PMD ET L+ YI+ +L LN+VAF I+C CY+K
Sbjct: 489 GGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIK 548
Query: 604 IYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILL 663
IY VRNP+ +KDTKIAK+MA+LIFTDF CMAPISF+A+SA PLITV+NSK+LL
Sbjct: 549 IYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLL 608
Query: 664 VLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYR 707
VLFYP+NSCANPFLYAIFTK FQRD F+LLSKFG CKR+A+ YR
Sbjct: 609 VLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYR 652
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 630 bits (1625), Expect = e-180
Identities = 344/703 (48%), Positives = 453/703 (64%), Gaps = 53/703 (7%)
Query: 6 LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64
L+ L+ L L G GC C C F + IPS LP + L+ + T L
Sbjct: 5 LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
Query: 65 RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124
R I AFS ++ +I +S + L+ +E+ F NL K+ I I NL YI+P+A +
Sbjct: 59 RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
Query: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184
LP L++L I NTG+K PD+ K++S +L+I DN + +I N+F GL E++ L L
Sbjct: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQKV-LLDIQDNINIHTIERNSFVGLSFESVILWL 177
Query: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSK 244
NG + AFNGT+LD + L+ N L + D F G SGP +LD+S+T + +LPS
Sbjct: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVILDISRTRIHSLPSY 236
Query: 245 GLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNES 304
GLE+LK+L AR+T+ LKKLP + L A L+YPSHCCAF N ++ L + CN+S
Sbjct: 237 GLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPI-CNKS 295
Query: 305 SMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEII 364
+ R+ V+ + Q S +D N + Y F+ E
Sbjct: 296 IL-----RQEVDYMTQARGQR--------------SSLAED--NESSYSRGFDMTYTE-- 332
Query: 365 GFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFV 424
+DY +C + D+ C+PK D FNPCEDIMGY LR+++WF+
Sbjct: 333 --------------------FDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFI 372
Query: 425 SLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNH 484
S+LA+ GN+ VL+IL TS YKL VPRFLMCNLAFAD C+G+YLLLIASVD++T S+Y+N+
Sbjct: 373 SILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNY 432
Query: 485 AIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVG 544
AIDWQTG GC+ AGFFTVFASELSVYTLT ITLERW+ IT AM+LD K++LRHA ++MV
Sbjct: 433 AIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVM 492
Query: 545 GWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKI 604
GW+ F AL P+ GISSY KVSICLPMD ++PL+ Y++ +L LN++AFV++C CY+ I
Sbjct: 493 GWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHI 552
Query: 605 YITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLV 664
Y+TVRNP DT+IAKRMA+LIFTDF+CMAPISF+A+SA L PLITVS +KILLV
Sbjct: 553 YLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLV 612
Query: 665 LFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYR 707
LF+P+NSCANPFLYAIFTK F+RD FILLSK G + QAQ YR
Sbjct: 613 LFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYR 655
>gi|217330610 thyroid stimulating hormone receptor isoform 3
precursor [Homo sapiens]
Length = 274
Score = 470 bits (1209), Expect = e-132
Identities = 245/272 (90%), Positives = 248/272 (91%), Gaps = 13/272 (4%)
Query: 1 MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI 60
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
Sbjct: 1 MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI 60
Query: 61 ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD 120
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
Sbjct: 61 ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD 120
Query: 121 ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL 180
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
Sbjct: 121 ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL 180
Query: 181 TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTA 240
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL A
Sbjct: 181 TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL----VENVA 236
Query: 241 LPSKGLEHLKELIARNTWTLKKLPL---SLSF 269
+ KG K L +W L +LPL SLSF
Sbjct: 237 VSGKGF--CKSLF---SW-LYRLPLGRKSLSF 262
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 469 bits (1208), Expect = e-132
Identities = 258/537 (48%), Positives = 345/537 (64%), Gaps = 25/537 (4%)
Query: 192 VQGYAFNGT-KLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTAL------PSK 244
+Q AF+G L+ + +++N L VI+ D F + P L ++ L +
Sbjct: 61 IQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNL---PKLHEIRIEKANNLLYINPEAFQ 117
Query: 245 GLEHLKELIARNTWTLKKLP--LSLSFLHLTRADLSYPSHCCAFKNQKKIRGILES--LM 300
L +L+ L+ NT +K LP + L D+ + + + ES L
Sbjct: 118 NLPNLQYLLISNTG-IKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILW 176
Query: 301 CNESSMQSLRQ----RKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFF 356
N++ +Q + ++ LN + EE D G + H + +
Sbjct: 177 LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILSELHPICNKSILR 236
Query: 357 EEQEDEIIGFGQE---LKNPQEETLQAFDSHY---DYTICGDSEDMVCTPKSDEFNPCED 410
+E + GQ ++ + + FD Y DY +C + D+ C+PK D FNPCED
Sbjct: 237 QEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCED 296
Query: 411 IMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLI 470
IMGY LR+++WF+S+LA+ GN+ VL+IL TS YKL VPRFLMCNLAFAD C+G+YLLLI
Sbjct: 297 IMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLI 356
Query: 471 ASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLD 530
ASVD++T S+Y+N+AIDWQTG GC+ AGFFTVFASELSVYTLT ITLERW+ IT AM+LD
Sbjct: 357 ASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLD 416
Query: 531 RKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLN 590
K++LRHA ++MV GW+ F AL P+ GISSY KVSICLPMD ++PL+ Y++ +L LN
Sbjct: 417 CKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLN 476
Query: 591 IVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILN 650
++AFV++C CY+ IY+TVRNP DT+IAKRMA+LIFTDF+CMAPISF+A+SA L
Sbjct: 477 VLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLK 536
Query: 651 KPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYR 707
PLITVS +KILLVLF+P+NSCANPFLYAIFTK F+RD FILLSK G + QAQ YR
Sbjct: 537 VPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYR 593
Score = 124 bits (311), Expect = 3e-28
Identities = 83/227 (36%), Positives = 120/227 (52%), Gaps = 9/227 (3%)
Query: 6 LLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPS-LPPSTQTLKLIETHL 64
L+ L+ L L G GC C C F + IPS LP + L+ + T L
Sbjct: 5 LVSLLAFLSL-----GSGCHHRICHCSNRV-FLCQESKVTEIPSDLPRNAIELRFVLTKL 58
Query: 65 RTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKE 124
R I AFS ++ +I +S + L+ +E+ F NL K+ I I NL YI+P+A +
Sbjct: 59 RVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQN 118
Query: 125 LPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKL 184
LP L++L I NTG+K PD+ K++S +L+I DN + +I N+F GL E++ L L
Sbjct: 119 LPNLQYLLISNTGIKHLPDVHKIHSLQ-KVLLDIQDNINIHTIERNSFVGLSFESVILWL 177
Query: 185 YNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL 231
NG + AFNGT+LD + L+ N L + D F G SGP +L
Sbjct: 178 NKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGA-SGPVIL 223
>gi|64085161 thyroid stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 253
Score = 469 bits (1208), Expect = e-132
Identities = 231/231 (100%), Positives = 231/231 (100%)
Query: 1 MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI 60
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI
Sbjct: 1 MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLI 60
Query: 61 ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD 120
ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD
Sbjct: 61 ETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPD 120
Query: 121 ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL 180
ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL
Sbjct: 121 ALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETL 180
Query: 181 TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL 231
TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL
Sbjct: 181 TLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLL 231
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 190 bits (482), Expect = 5e-48
Identities = 171/704 (24%), Positives = 306/704 (43%), Gaps = 90/704 (12%)
Query: 32 HQEEDFRVTCKDIQRIPSLPPSTQTLKLIETH---LRTIPSHAFSNLPNISRIYVSIDVT 88
H E + ++ P+ + LK + H +R+IP AF P++ I+ D
Sbjct: 234 HSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF-YDNP 292
Query: 89 LQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVY 148
+Q + +F +L ++ + + +T PD L L+ L + + P
Sbjct: 293 IQFVGRSAFQHLPELRTLTLNGASQITEF-PD-LTGTANLESLTLTGAQISSLPQTVCNQ 350
Query: 149 STDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGT-KLDAVYL 207
+ L++ D Y + +F +C + + L +N ++ F L ++ L
Sbjct: 351 LPN----LQVLDLSYNLLEDLPSFS-VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNL 405
Query: 208 NKNKYLTVIDKDAFGGVYSGPSL--LDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPL 265
NK + +I +AF + PSL LD+S +++ P GL L L L+ L
Sbjct: 406 AWNK-IAIIHPNAFSTL---PSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLIS 461
Query: 266 SLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQE 325
S +F L ++ Y CCAF +C + S + K N+ LH+
Sbjct: 462 SENFPELKVIEMPYAYQCCAFG------------VCENAYKISNQWNKGDNSSMDDLHK- 508
Query: 326 YEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHY 385
K+ FQ + ED ++ F EE L+A S
Sbjct: 509 ------------KDAGMFQAQDER--------DLEDFLLDF--------EEDLKALHS-- 538
Query: 386 DYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYK 445
+ C+P F PCE ++ +RI VW +++LAL N V + S
Sbjct: 539 ----------VQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLY 588
Query: 446 LNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFAS 505
++ + L+ +A + G+ ++A VD +T + H W+ G GC+ GF ++FAS
Sbjct: 589 ISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFAS 648
Query: 506 ELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAK 565
E SV+ LT+ LER +++ ++ + + K I++ + +A +PL+G S Y
Sbjct: 649 ESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA 708
Query: 566 VSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK----DTK 621
+CLP+ P + Y+V ++ LN + F+++ Y K+Y + + GD D
Sbjct: 709 SPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNL-----DKGDLENIWDCS 763
Query: 622 IAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIF 681
+ K +A+L+FT+ I P++F + S+++N I+ K +L++ PL +C NP LY +F
Sbjct: 764 MVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILF 823
Query: 682 TKAFQRDVFILLSKFGICKRQAQAYRGQRVPPK---NSTDIQVQ 722
F+ D+ L ++Q + + P NS D++ Q
Sbjct: 824 NPHFKEDLVSL-------RKQTYVWTRSKHPSLMSINSDDVEKQ 860
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/293 (24%), Positives = 121/293 (41%), Gaps = 77/293 (26%)
Query: 5 DLLQLVLLLDLPRDLG-GMGCSSP---------PCECHQEED----FRVTCKDI------ 44
D +L +LL LP L G SSP P CH E D RV C D+
Sbjct: 2 DTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELP 61
Query: 45 ------------------QRIPSLPPST---QTLKLIETHLRTIPSHAFSNLPNISRIYV 83
Q +P+ PS + L+L L IP AF+ L ++ ++ +
Sbjct: 62 SNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSL-KVLM 120
Query: 84 SIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPD 143
+ L+ + + + NL + + + + +++Y+ P L L+ L +
Sbjct: 121 LQNNQLRHVPTEALQNLRSLQSLRL-DANHISYVPPSCFSGLHSLRHLWL---------- 169
Query: 144 LTKVYSTDIFFILEITDNPYMTSIPVNAFQGL-CNETLTLKLYNNGFTSVQGYAF-NGTK 201
D+ +T IPV AF+ L + +TL L N + YAF N +
Sbjct: 170 ----------------DDNALTEIPVQAFRSLSALQAMTLAL--NKIHHIPDYAFGNLSS 211
Query: 202 LDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPS--KGLEHLKEL 252
L ++L+ N+ + + K F G++S LD++ ++ P+ + L +LKEL
Sbjct: 212 LVVLHLHNNR-IHSLGKKCFDGLHS-LETLDLNYNNLDEFPTAIRTLSNLKEL 262
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 180 bits (457), Expect = 4e-45
Identities = 157/670 (23%), Positives = 291/670 (43%), Gaps = 68/670 (10%)
Query: 52 PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNT 111
P+ Q L L + +IP AF+NL ++ +++ + ++ L H F L + +++ N
Sbjct: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNN-KIRSLSQHCFDGLDNLETLDL-NY 234
Query: 112 RNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNA 171
NL P A+K LP LK LG + + + PD + + + DNP ++ + +A
Sbjct: 235 NNLGEF-PQAIKALPSLKELGFHSNSISVIPD-GAFDGNPLLRTIHLYDNP-LSFVGNSA 291
Query: 172 FQGLCN--------ETLTLKLYN-NGFTSVQGYAFNGTKLDAVYLN---KNKYLTVIDKD 219
F L + ++ + N G ++ GTK+ ++ N + K L +D
Sbjct: 292 FHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL- 350
Query: 220 AFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLH-------- 271
++ + PS +L + +KE + +L+ L LS + +H
Sbjct: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
Query: 272 ----LTRADLSY------PSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVN--ALN 319
+T D+S+ P+ NQ K+ G N ++L + VN +L+
Sbjct: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVG-------NFKLKEALAAKDFVNLRSLS 463
Query: 320 SPLHQEYEENLG-DSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETL 378
P + G DS + H+ A E+ + L+N + +
Sbjct: 464 VPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQ-----EKGTADAANVTSTLENEEHSQI 518
Query: 379 QAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLI 438
CTP + F PCE ++G +R+ VWF+ L+AL N+ V+L
Sbjct: 519 IIH----------------CTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILT 562
Query: 439 LLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAG 498
S L + + ++ ++ MG+Y ++ +D + + I W+TG GC AG
Sbjct: 563 TFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAG 622
Query: 499 FFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLV 558
F VF+SE +++ L + T+ER + M+ + L+ + ++ + PL
Sbjct: 623 FLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLF 682
Query: 559 GISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK 618
Y+ +CLP T +L + V ++ LN +AF+++ Y K+Y + + +
Sbjct: 683 HRGEYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQ 742
Query: 619 DTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLY 678
+ I K +A LIFT+ I P++F++ + ++ I+ K + ++F+PL +C NP LY
Sbjct: 743 SSMI-KHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLY 801
Query: 679 AIFTKAFQRD 688
F F+ D
Sbjct: 802 VFFNPKFKED 811
Score = 30.8 bits (68), Expect = 4.9
Identities = 38/161 (23%), Positives = 72/161 (44%), Gaps = 18/161 (11%)
Query: 100 LSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEI- 158
LS T + N+T + DA K P L+ L + DL+ ++ + + E+
Sbjct: 55 LSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGN------DLSFIHPKALSGLKELK 108
Query: 159 ---TDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYLT 214
N + ++P A +GL + +L+L N TSV +F G +L ++L+ N LT
Sbjct: 109 VLTLQNNQLKTVPSEAIRGL-SALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNS-LT 166
Query: 215 VIDKDAFGGVYSGPSL--LDVSQTSVTALPSKGLEHLKELI 253
+ + P+L L ++ ++++P +L L+
Sbjct: 167 EVPVHPLSNL---PTLQALTLALNKISSIPDFAFTNLSSLV 204
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 151 bits (381), Expect = 2e-36
Identities = 174/727 (23%), Positives = 306/727 (42%), Gaps = 62/727 (8%)
Query: 52 PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNT 111
P+ Q + L + IP +AF NL ++ +++ + +Q L +HSF L + +++
Sbjct: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYN 192
Query: 112 RNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNA 171
+ + P A++ L L+ LG N +K P+ + + + DNP + + +A
Sbjct: 193 KLQEF--PVAIRTLGRLQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNP-IQFVGRSA 248
Query: 172 FQGLCN-ETLTLKLYNNGFTSVQGYA-FNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPS 229
FQ L TL+L NG +Q + GT + + ++ G P
Sbjct: 249 FQYLPKLHTLSL----NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS---GMCQQLPR 301
Query: 230 L--LDVSQTSVTALPS-KGLEHLKELIARNT--WTLKKLPLSLSFLHLTRADLSYPSHCC 284
L L++S + LPS + L+E+ ++ W + S L DLS+ +
Sbjct: 302 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS-QLSSLQALDLSWNAIRS 360
Query: 285 AFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQ 344
L L ++ + +L + L +H + + NL S K+
Sbjct: 361 IHPEAFSTLHSLVKLDLTDNQLTTL----PLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 416
Query: 345 DTHNNAHYYV---------FFE-----EQEDEIIGFGQELKNPQEETLQAFDSHYDYTI- 389
+ Y FF+ E ED + + K P + ++HYD +
Sbjct: 417 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 476
Query: 390 -----CGDSE---DMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLT 441
DS+ + C+P F PCE + +R+ VW + LL++L N VLL +
Sbjct: 477 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 536
Query: 442 SH-YKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFF 500
L +F++ +A A+ G+ L+ASVD T ++ + W+TG GC GF
Sbjct: 537 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 596
Query: 501 TVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGI 560
V SE SV LT+ ++ +++ + L A ++G L A LPL +
Sbjct: 597 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 656
Query: 561 SSYAKVSICLPM--DTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK 618
Y +CLP P AL + V ++ +N F++V Y+K+Y + +
Sbjct: 657 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE-AVW 715
Query: 619 DTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLY 678
D + + +A LIF D + P++F + +++L +T K +L++ PL +C NP LY
Sbjct: 716 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY 775
Query: 679 AIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDV 738
+F F+ D+ L + G A A G +++K + + Q L DV
Sbjct: 776 LLFNPHFRDDLRRLRPRAGDSGPLAYAAAG-----------ELEKSSCDSTQALVAFSDV 824
Query: 739 YELIENS 745
++E S
Sbjct: 825 DLILEAS 831
Score = 33.5 bits (75), Expect = 0.76
Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 35/213 (16%)
Query: 55 QTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNL 114
+ L+L HL IP AFS L Y+L I + L
Sbjct: 41 EELRLSGNHLSHIPGQAFSGL----------------------YSLK----ILMLQNNQL 74
Query: 115 TYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQG 174
I +AL ELP L+ L + + + P+ + + + + D+ +T IPV A
Sbjct: 75 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLW--LDDNALTEIPVRALNN 132
Query: 175 L-CNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSL-L 231
L + +TL L N + + YAF N T L ++L+ N+ + + +F G+++ +L L
Sbjct: 133 LPALQAMTLAL--NRISHIPDYAFQNLTSLVVLHLHNNR-IQHLGTHSFEGLHNLETLDL 189
Query: 232 DVSQTSVTALPSKGLEHLKELIARNTWTLKKLP 264
+ ++ + + L L+EL N +K +P
Sbjct: 190 NYNKLQEFPVAIRTLGRLQELGFHNN-NIKAIP 221
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 151 bits (381), Expect = 2e-36
Identities = 174/727 (23%), Positives = 306/727 (42%), Gaps = 62/727 (8%)
Query: 52 PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNT 111
P+ Q + L + IP +AF NL ++ +++ + +Q L +HSF L + +++
Sbjct: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYN 244
Query: 112 RNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNA 171
+ + P A++ L L+ LG N +K P+ + + + DNP + + +A
Sbjct: 245 KLQEF--PVAIRTLGRLQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNP-IQFVGRSA 300
Query: 172 FQGLCN-ETLTLKLYNNGFTSVQGYA-FNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPS 229
FQ L TL+L NG +Q + GT + + ++ G P
Sbjct: 301 FQYLPKLHTLSL----NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS---GMCQQLPR 353
Query: 230 L--LDVSQTSVTALPS-KGLEHLKELIARNT--WTLKKLPLSLSFLHLTRADLSYPSHCC 284
L L++S + LPS + L+E+ ++ W + S L DLS+ +
Sbjct: 354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS-QLSSLQALDLSWNAIRS 412
Query: 285 AFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQ 344
L L ++ + +L + L +H + + NL S K+
Sbjct: 413 IHPEAFSTLHSLVKLDLTDNQLTTL----PLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 468
Query: 345 DTHNNAHYYV---------FFE-----EQEDEIIGFGQELKNPQEETLQAFDSHYDYTI- 389
+ Y FF+ E ED + + K P + ++HYD +
Sbjct: 469 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 528
Query: 390 -----CGDSE---DMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLT 441
DS+ + C+P F PCE + +R+ VW + LL++L N VLL +
Sbjct: 529 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 588
Query: 442 SH-YKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFF 500
L +F++ +A A+ G+ L+ASVD T ++ + W+TG GC GF
Sbjct: 589 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 648
Query: 501 TVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGI 560
V SE SV LT+ ++ +++ + L A ++G L A LPL +
Sbjct: 649 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 708
Query: 561 SSYAKVSICLPM--DTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK 618
Y +CLP P AL + V ++ +N F++V Y+K+Y + +
Sbjct: 709 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE-AVW 767
Query: 619 DTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLY 678
D + + +A LIF D + P++F + +++L +T K +L++ PL +C NP LY
Sbjct: 768 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY 827
Query: 679 AIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDV 738
+F F+ D+ L + G A A G +++K + + Q L DV
Sbjct: 828 LLFNPHFRDDLRRLRPRAGDSGPLAYAAAG-----------ELEKSSCDSTQALVAFSDV 876
Query: 739 YELIENS 745
++E S
Sbjct: 877 DLILEAS 883
Score = 33.5 bits (75), Expect = 0.76
Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 35/213 (16%)
Query: 55 QTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNL 114
+ L+L HL IP AFS L Y+L I + L
Sbjct: 93 EELRLSGNHLSHIPGQAFSGL----------------------YSLK----ILMLQNNQL 126
Query: 115 TYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQG 174
I +AL ELP L+ L + + + P+ + + + + D+ +T IPV A
Sbjct: 127 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLW--LDDNALTEIPVRALNN 184
Query: 175 L-CNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSL-L 231
L + +TL L N + + YAF N T L ++L+ N+ + + +F G+++ +L L
Sbjct: 185 LPALQAMTLAL--NRISHIPDYAFQNLTSLVVLHLHNNR-IQHLGTHSFEGLHNLETLDL 241
Query: 232 DVSQTSVTALPSKGLEHLKELIARNTWTLKKLP 264
+ ++ + + L L+EL N +K +P
Sbjct: 242 NYNKLQEFPVAIRTLGRLQELGFHNN-NIKAIP 273
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 146 bits (368), Expect = 8e-35
Identities = 144/566 (25%), Positives = 253/566 (44%), Gaps = 63/566 (11%)
Query: 167 IPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYLTVIDKDAFGGVY 225
+P + F+ ++ L L NN TS+ YAF G L +YL+ N+ +T + F ++
Sbjct: 141 LPPDCFKNY-HDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR-ITFLKPGVFEDLH 198
Query: 226 SGPSLL--DVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRA---DLSYP 280
L+ D + ++ GL L L+ N L +LP H+ R DL
Sbjct: 199 RLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNN-VLTRLPDKPLCQHMPRLHWLDLE-G 256
Query: 281 SHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALN----SPLHQEYEENLGDSIV- 335
+H +N L + C+ ++ +R+ K +N LN +PL + E +LG + +
Sbjct: 257 NHIHNLRN-------LTFISCSNLTVLVMRKNK-INHLNENTFAPLQKLDELDLGSNKIE 308
Query: 336 --------GYKEKSKFQDTHN-----NAHYYVFFEEQED------EIIGFGQELKNPQEE 376
KE S+ ++N A+ + + + + EI Q + P
Sbjct: 309 NLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMN 368
Query: 377 TLQAFDSHYDYTICGDSEDM-VCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFV 435
+ + Y CG + + C P +D + E+++ R+ VW VS + GN+FV
Sbjct: 369 LSHIYFKKFQY--CGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFV 426
Query: 436 LLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCN 495
+ + + + + +L AD MG+YL +I DL EY HA W C
Sbjct: 427 ICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQ 486
Query: 496 TAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALL 555
G + ++E+SV LT +TLE++ I + R R + R +++ W+ F++A +
Sbjct: 487 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCR-TITVLILIWITGFIVAFI 545
Query: 556 PLVG----ISSYAKVSICLPM---DTETPLALAYIVFV-LTLNIVAFVIVCCCYVKIYIT 607
PL + Y +C P+ DTE+ A Y V + L +N+ AF+I+ Y ++ +
Sbjct: 546 PLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYS 605
Query: 608 VRNPQY------NPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLI-TVSNSK 660
V N K+ +AKR ++FTD +C PI ++L + T+++
Sbjct: 606 VHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWV 665
Query: 661 ILLVLFYPLNSCANPFLYAIFTKAFQ 686
++ +L P+NS NP LY + T+ F+
Sbjct: 666 VIFIL--PINSALNPILYTLTTRPFK 689
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/215 (20%), Positives = 97/215 (45%), Gaps = 7/215 (3%)
Query: 43 DIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSK 102
+++ +PS+ + + L +R +P F N ++ ++Y+ + + + ++F L+
Sbjct: 117 NLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQ-NNKITSISIYAFRGLNS 175
Query: 103 VTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNP 162
+T + + + R +T++ P ++L L++L I + L T Y + +L + +N
Sbjct: 176 LTKLYLSHNR-ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPT-FYGLNSLILLVLMNN- 232
Query: 163 YMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAF 221
+T +P L L N +++ F + + L + + KNK + ++++ F
Sbjct: 233 VLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNK-INHLNENTF 291
Query: 222 GGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARN 256
+ LD+ + LP + LKEL N
Sbjct: 292 APLQKLDE-LDLGSNKIENLPPLIFKDLKELSQLN 325
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 143 bits (361), Expect = 5e-34
Identities = 172/724 (23%), Positives = 303/724 (41%), Gaps = 62/724 (8%)
Query: 55 QTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNL 114
+ L+L HL IP AFS L ++ +I + + L + + + + L + +++ +
Sbjct: 50 EELRLSGNHLSHIPGQAFSGLYSL-KILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ 108
Query: 115 TYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQG 174
+ P A++ L L+ LG N +K P+ + + + DNP + + +AFQ
Sbjct: 109 EF--PVAIRTLGRLQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNP-IQFVGRSAFQY 164
Query: 175 LCN-ETLTLKLYNNGFTSVQGYA-FNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSL-- 230
L TL+L NG +Q + GT + + ++ G P L
Sbjct: 165 LPKLHTLSL----NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS---GMCQQLPRLRV 217
Query: 231 LDVSQTSVTALPS-KGLEHLKELIARNT--WTLKKLPLSLSFLHLTRADLSYPSHCCAFK 287
L++S + LPS + L+E+ ++ W + S L DLS+ +
Sbjct: 218 LELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS-QLSSLQALDLSWNAIRSIHP 276
Query: 288 NQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTH 347
L L ++ + +L + L +H + + NL S K+
Sbjct: 277 EAFSTLHSLVKLDLTDNQLTTL----PLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL 332
Query: 348 NNAHYYV---------FFE-----EQEDEIIGFGQELKNPQEETLQAFDSHYDYTI---- 389
+ Y FF+ E ED + + K P + ++HYD +
Sbjct: 333 EVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQ 392
Query: 390 --CGDSE---DMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSH- 443
DS+ + C+P F PCE + +R+ VW + LL++L N VLL +
Sbjct: 393 LEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGP 452
Query: 444 YKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVF 503
L +F++ +A A+ G+ L+ASVD T ++ + W+TG GC GF V
Sbjct: 453 VPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVL 512
Query: 504 ASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSY 563
SE SV LT+ ++ +++ + L A ++G L A LPL + Y
Sbjct: 513 GSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEY 572
Query: 564 AKVSICLPM--DTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTK 621
+CLP P AL + V ++ +N F++V Y+K+Y + + D
Sbjct: 573 GASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE-AVWDCA 631
Query: 622 IAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIF 681
+ + +A LIF D + P++F + +++L +T K +L++ PL +C NP LY +F
Sbjct: 632 MVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLF 691
Query: 682 TKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYEL 741
F+ D+ L + G A A G +++K + + Q L DV +
Sbjct: 692 NPHFRDDLRRLRPRAGDSGPLAYAAAG-----------ELEKSSCDSTQALVAFSDVDLI 740
Query: 742 IENS 745
+E S
Sbjct: 741 LEAS 744
Score = 38.9 bits (89), Expect = 0.018
Identities = 55/253 (21%), Positives = 103/253 (40%), Gaps = 18/253 (7%)
Query: 35 EDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLES 94
++F V + + R+ Q L +++ IP AF P + I+ D +Q +
Sbjct: 108 QEFPVAIRTLGRL-------QELGFHNNNIKAIPEKAFMGNPLLQTIHF-YDNPIQFVGR 159
Query: 95 HSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFF 154
+F L K+ + + ++ PD LK L+ L + G+++ P
Sbjct: 160 SAFQYLPKLHTLSLNGAMDIQEF-PD-LKGTTSLEILTLTRAGIRLLPS-GMCQQLPRLR 216
Query: 155 ILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYL 213
+LE++ N ++ C + + L +N + F+ + L A+ L+ N +
Sbjct: 217 VLELSHNQIEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-I 271
Query: 214 TVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLT 273
I +AF ++S L D++ +T LP GL L L + L + SF L
Sbjct: 272 RSIHPEAFSTLHSLVKL-DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLR 330
Query: 274 RADLSYPSHCCAF 286
++ Y CC +
Sbjct: 331 ILEVPYAYQCCPY 343
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 131 bits (330), Expect = 2e-30
Identities = 154/692 (22%), Positives = 285/692 (41%), Gaps = 123/692 (17%)
Query: 29 CECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVT 88
C+C +E + D++ +P + + L L + + ++P F + +I++ +
Sbjct: 115 CDC-KETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNC- 172
Query: 89 LQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVY 148
++ + +F+ L + + + N +T + P K+L L +L
Sbjct: 173 IRHISRKAFFGLCNLQILYL-NHNCITTLRPGIFKDLHQLTWL----------------- 214
Query: 149 STDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSV------QGYAFNGTKL 202
IL+ DNP +T I F GL N L + NN ++ Q N L
Sbjct: 215 ------ILD--DNP-ITRISQRLFTGL-NSLFFLSMVNNYLEALPKQMCAQMPQLNWVDL 264
Query: 203 DAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKK 262
+ N+ KYLT + L +V LP + + E + L +
Sbjct: 265 EG---NRIKYLT------------NSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGE 309
Query: 263 LPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILES----LMCNESSMQSLRQRKSVNAL 318
L LS + T +LS H FK+ K ++ + S + +++ +SL+Q +S++
Sbjct: 310 LDLSSN----TITELS--PHL--FKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLD-- 359
Query: 319 NSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETL 378
L + N+ + FQ N +H Y KN
Sbjct: 360 ---LERIEIPNINTRM--------FQPMKNLSHIY----------------FKN------ 386
Query: 379 QAFDSHYDYTICGDSEDM-VCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLL 437
+ C + + +C P +D + ED++ LRI VW ++ + GN+FV+
Sbjct: 387 --------FRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIG 438
Query: 438 ILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTA 497
+ + + L AD MG+YL + D+ +Y +A+ W C
Sbjct: 439 MRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLM 498
Query: 498 GFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPL 557
GF + ++E+SV LT +TLE++ I F R + R I++ W+ FL+A++P
Sbjct: 499 GFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGK-RQTSVILICIWMAGFLIAVIPF 557
Query: 558 VGI----SSYAKVSICLPM---DTETPLALAYIVFV-LTLNIVAFVIVCCCYVKIYITVR 609
+ Y K +C P+ TE + Y + + L +N++AF+I+ Y+ ++ +++
Sbjct: 558 WNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQ 617
Query: 610 NPQY------NPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILL 663
N ++ +A R ++F+D IC P+ + ++ + S I +
Sbjct: 618 KTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWI-V 676
Query: 664 VLFYPLNSCANPFLYAIFTKAFQRDVFILLSK 695
+ F P+NS NP LY + T F+ + LL K
Sbjct: 677 IFFLPVNSALNPILYTLTTNFFKDKLKQLLHK 708
>gi|4557859 somatostatin receptor 2 [Homo sapiens]
Length = 369
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/310 (23%), Positives = 131/310 (42%), Gaps = 29/310 (9%)
Query: 396 MVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCN 455
+V T S++ P D+ L + + V ++ L GN V+ ++L + + N
Sbjct: 25 VVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILN 84
Query: 456 LAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPG-CNTAGFFTVFASELSVYTLTV 514
LA AD + L +A H W G C S++ LTV
Sbjct: 85 LAIADELFMLGLPFLAMQVALVH---------WPFGKAICRVVMTVDGINQFTSIFCLTV 135
Query: 515 ITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLV---GISS--YAKVSIC 569
++++R+ A+ ++ + R R A I + W LL +LP++ G+ S + + S
Sbjct: 136 MSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVS-LLVILPIMIYAGLRSNQWGRSSCT 194
Query: 570 LPMDTETPL-ALAYIVFVLTLN-IVAFVIVCCCYVKIYITVRNPQYNPGDK-----DTKI 622
+ E+ +I++ L +V I+C CY+ I I V++ G + K+
Sbjct: 195 INWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKV 254
Query: 623 AKRMAVLIFTDFICMAPISFYALSAILN--KPLITVSNSKILLVLFYPLNSCANPFLYAI 680
+ +++++ C P + +S++ P + +V+ NSCANP LYA
Sbjct: 255 TRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAF 314
Query: 681 ----FTKAFQ 686
F K+FQ
Sbjct: 315 LSDNFKKSFQ 324
>gi|4557857 somatostatin receptor 1 [Homo sapiens]
Length = 391
Score = 72.4 bits (176), Expect = 1e-12
Identities = 79/282 (28%), Positives = 118/282 (41%), Gaps = 35/282 (12%)
Query: 424 VSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYN 483
V L+ L GN V+ ++L + NLA AD LL+ SV S
Sbjct: 68 VCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADE------LLMLSVPFLVTSTLLR 121
Query: 484 HAIDWQTGPG-CNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIM 542
H W G C S+Y LTV++++R+ A+ ++ R R A +
Sbjct: 122 H---WPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVN 178
Query: 543 VGGWVCCFLLALLPLVGISSYAKVS---ICLPMDTETPLALAYIVFVLTLNIVAFVI--- 596
+G WV LL +LP+V S A S + M P + FVL ++ F++
Sbjct: 179 LGVWVLS-LLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVG 237
Query: 597 -VCCCYVKIYITVRNPQYNPGDKDTKIAKR-------MAVLIFTDFICMAPISFYALSAI 648
+C CYV I +R G + K ++R M V++F IC P FY + +
Sbjct: 238 AICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFV--ICWMP--FYVVQLV 293
Query: 649 ---LNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQR 687
+ TVS ++L NSCANP LY + F+R
Sbjct: 294 NVFAEQDDATVSQLSVILGY---ANSCANPILYGFLSDNFKR 332
>gi|30023826 G-protein coupled purinergic receptor P2Y8 [Homo
sapiens]
Length = 359
Score = 72.0 bits (175), Expect = 2e-12
Identities = 75/296 (25%), Positives = 128/296 (43%), Gaps = 46/296 (15%)
Query: 417 LRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASV--- 473
L +V V+ +++ GN+F L +L + M NL+ D L++ASV
Sbjct: 26 LPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVIFMINLSVTD-------LMLASVLPF 78
Query: 474 DLYTHSEYYNHAIDWQTGPG-CN--TAGFFTVFASELSVYTLTVITLERWYAITFAMRLD 530
+Y H ++ W G CN T F+ S S+ T+T I++ER+ + + +
Sbjct: 79 QIYYHCNRHH----WVFGVLLCNVVTVAFYANMYS--SILTMTCISVERFLGVLYPLSSK 132
Query: 531 RKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMD-------------TETP 577
R R R+A A G W LL L +S A+ + P+ T P
Sbjct: 133 RWRRRRYAVAACAGTW-------LLLLTALSPLARTDLTYPVHALGIITCFDVLKWTMLP 185
Query: 578 LALAYIVFVLT----LNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTD 633
+ VF+ T L ++ FVI CY + + + G + + A +A ++
Sbjct: 186 SVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAAVVLLA 245
Query: 634 FI-CMAPISFYALSAILNKPLITVSNSKI--LLVLFYPLNSCANPFLYAIFTKAFQ 686
F+ C AP +F L+ I+++ S + L + LN+C +PF+Y ++ FQ
Sbjct: 246 FVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREFQ 301
>gi|161484640 neuromedin B receptor [Homo sapiens]
Length = 390
Score = 72.0 bits (175), Expect = 2e-12
Identities = 73/287 (25%), Positives = 122/287 (42%), Gaps = 35/287 (12%)
Query: 427 LALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAI 486
+ LLGN+ ++ I +T+ +VP + NLA D LLL+ V + +++
Sbjct: 56 VGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDL-----LLLLTCVPVDASRYFFD--- 107
Query: 487 DWQTGP-GCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGG 545
+W G GC + + +SV+TLT ++ +R+ AI M + L C +G
Sbjct: 108 EWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGI 167
Query: 546 WVCCFLLALLPLVGISSYAKVS----------ICLPMDTETPLALAYIVFVLTLNIVAFV 595
WV LLA +P S A++S I P E + ++ L ++
Sbjct: 168 WVVSVLLA-VPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLA 226
Query: 596 IVCCCYVKIYITVRNPQYN-PGD------KDTKIAKRMA--VLIFTD--FICMAPISFYA 644
I+ Y I T+ +N PG+ K + KR+A VL+F C P
Sbjct: 227 IISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILY 286
Query: 645 LSAILNKPLITVSNSKILLVLFYPL----NSCANPFLYAIFTKAFQR 687
+ N I S +++ L + NSC NPF + +++F+R
Sbjct: 287 MYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRR 333
>gi|4826706 EBV-induced G protein-coupled receptor 2 [Homo sapiens]
Length = 361
Score = 71.6 bits (174), Expect = 3e-12
Identities = 80/355 (22%), Positives = 143/355 (40%), Gaps = 53/355 (14%)
Query: 406 NPCEDIMGYKFLRIVV----WFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADF 461
N C+ + RIV+ V ++ L+GN+ L++++ + K+N NL +D
Sbjct: 19 NDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISD- 77
Query: 462 CMGMYLLLIASVDLYTHSEYYNHAIDWQTGPG-CNTAGFFTVFASELSVYTLTVITLERW 520
++ + L T YY DW+ G C + V +T ++++R+
Sbjct: 78 -------ILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRF 130
Query: 521 YAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISS--YAKVSICL--PMDTET 576
A+ +R ++ R+ HA + + W+ F L L+ S A+ C+ P ET
Sbjct: 131 IAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEET 190
Query: 577 P------LALAYIVFVLTLNI--VAFVIVCCCYVKIYITVR-NPQYNPGDKDTKIAKRMA 627
L +I +VL L I + + +CC K++ T + NP + K +
Sbjct: 191 KSLPWILLGACFIGYVLPLIIILICYSQICC---KLFRTAKQNPLTEKSGVNKKALNTII 247
Query: 628 VLIFTDFICMAPISFYALSAILNKPLITVSN------------SKILLVLFYPLNSCANP 675
++I +C P + ++ K + SN S V N C +P
Sbjct: 248 LIIVVFVLCFTPYHVAIIQHMIKK--LRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDP 305
Query: 676 FLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRV---PPKNSTDI-QVQKVTH 726
F+Y K ++R V +L KRQ V P +NS ++ + Q + H
Sbjct: 306 FIYFFACKGYKRKVMRML------KRQVSVSISSAVKSAPEENSREMTETQMMIH 354
>gi|5174593 melatonin receptor 1A [Homo sapiens]
Length = 350
Score = 69.7 bits (169), Expect = 1e-11
Identities = 61/287 (21%), Positives = 126/287 (43%), Gaps = 26/287 (9%)
Query: 417 LRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLY 476
L V+ F ++ +LGN+ V+L + + N + +LA AD + +Y + + ++
Sbjct: 30 LACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIF 89
Query: 477 THSEYYNHAIDWQTGP-GCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRL 535
+ W G C +GF + S++ +T I + R+ I +++ D+
Sbjct: 90 NNG--------WNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSS 141
Query: 536 RHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLN-IVAF 594
+++ ++ W+ L A+LP + + ++ AY + V+ + +V
Sbjct: 142 KNSLCYVLLIWLLT-LAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPM 200
Query: 595 VIVCCCYVKIYITV----------RNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYA 644
+IV CY++I+I V R P+ P D + + ++F IC AP++F
Sbjct: 201 IIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFA--ICWAPLNFIG 258
Query: 645 LSAILNKPLITVSNSKILLVLFYPL---NSCANPFLYAIFTKAFQRD 688
L+ + + + L V Y + NSC N +Y + + F+++
Sbjct: 259 LAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKE 305
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 69.3 bits (168), Expect = 1e-11
Identities = 86/371 (23%), Positives = 153/371 (41%), Gaps = 65/371 (17%)
Query: 405 FNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVP-RFLMCNLAFADFCM 463
F E ++ FL V+ L+A+LGN+ V++ + + + + +LAFAD +
Sbjct: 14 FGSVEKVVLLTFLSTVI----LMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV 69
Query: 464 GMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI 523
+ ++ +++L Y C V + S++ L I+L+R+YAI
Sbjct: 70 SVLVMPFGAIELVQDIWIYGEVF-------CLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 524 TFAMRLDRKIRLRHACAIMVGG-WVCCFLLALLPLV-GISSYAKVSICLPMDTETPLALA 581
+ R A+M+GG WV ++ LP++ G ++ + +
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 582 YIVFV------LTLNIVAFVI----VCCCYVKIYITVR--------------NPQYNPGD 617
Y VF+ +T ++VAF I + Y +IY+T + + + P
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS 242
Query: 618 KD----------TKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFY 667
D TK AK + +++ +C AP F+ + + P I + + F
Sbjct: 243 ADQHSTHRMRTETKAAKTLCIIMGCFCLCWAP--FFVTNIV--DPFIDYTVPGQVWTAFL 298
Query: 668 PL---NSCANPFLYAIFTKAFQRDVFILLSKFGIC---KRQAQAYRGQRVPPKNSTDIQV 721
L NS NPFLYA K+F+R I+L C + + + GQ VP +T +
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIIL----CCDDERYRRPSILGQTVPCSTTT---I 351
Query: 722 QKVTHEMRQGL 732
TH +R +
Sbjct: 352 NGSTHVLRDAV 362
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 68.9 bits (167), Expect = 2e-11
Identities = 86/368 (23%), Positives = 152/368 (41%), Gaps = 65/368 (17%)
Query: 405 FNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVP-RFLMCNLAFADFCM 463
F E ++ FL V+ L+A+LGN+ V++ + + + + +LAFAD +
Sbjct: 14 FGSVEKVVLLTFLSTVI----LMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV 69
Query: 464 GMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI 523
+ ++ +++L Y C V + S++ L I+L+R+YAI
Sbjct: 70 SVLVMPFGAIELVQDIWIYGEVF-------CLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 524 TFAMRLDRKIRLRHACAIMVGG-WVCCFLLALLPLV-GISSYAKVSICLPMDTETPLALA 581
+ R A+M+GG WV ++ LP++ G ++ + +
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 582 YIVFV------LTLNIVAFVI----VCCCYVKIYITVR--------------NPQYNPGD 617
Y VF+ +T ++VAF I + Y +IY+T + + + P
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS 242
Query: 618 KD----------TKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFY 667
D TK AK + +++ +C AP F+ + + P I + + F
Sbjct: 243 ADQHSTHRMRTETKAAKTLCIIMGCFCLCWAP--FFVTNIV--DPFIDYTVPGQVWTAFL 298
Query: 668 PL---NSCANPFLYAIFTKAFQRDVFILLSKFGIC---KRQAQAYRGQRVPPKNSTDIQV 721
L NS NPFLYA K+F+R I+L C + + + GQ VP +T +
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIIL----CCDDERYRRPSILGQTVPCSTTT---I 351
Query: 722 QKVTHEMR 729
TH +R
Sbjct: 352 NGSTHVLR 359
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 68.9 bits (167), Expect = 2e-11
Identities = 86/368 (23%), Positives = 152/368 (41%), Gaps = 65/368 (17%)
Query: 405 FNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVP-RFLMCNLAFADFCM 463
F E ++ FL V+ L+A+LGN+ V++ + + + + +LAFAD +
Sbjct: 14 FGSVEKVVLLTFLSTVI----LMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV 69
Query: 464 GMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI 523
+ ++ +++L Y C V + S++ L I+L+R+YAI
Sbjct: 70 SVLVMPFGAIELVQDIWIYGEVF-------CLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 524 TFAMRLDRKIRLRHACAIMVGG-WVCCFLLALLPLV-GISSYAKVSICLPMDTETPLALA 581
+ R A+M+GG WV ++ LP++ G ++ + +
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 582 YIVFV------LTLNIVAFVI----VCCCYVKIYITVR--------------NPQYNPGD 617
Y VF+ +T ++VAF I + Y +IY+T + + + P
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS 242
Query: 618 KD----------TKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFY 667
D TK AK + +++ +C AP F+ + + P I + + F
Sbjct: 243 ADQHSTHRMRTETKAAKTLCIIMGCFCLCWAP--FFVTNIV--DPFIDYTVPGQVWTAFL 298
Query: 668 PL---NSCANPFLYAIFTKAFQRDVFILLSKFGIC---KRQAQAYRGQRVPPKNSTDIQV 721
L NS NPFLYA K+F+R I+L C + + + GQ VP +T +
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIIL----CCDDERYRRPSILGQTVPCSTTT---I 351
Query: 722 QKVTHEMR 729
TH +R
Sbjct: 352 NGSTHVLR 359
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 68.9 bits (167), Expect = 2e-11
Identities = 86/368 (23%), Positives = 152/368 (41%), Gaps = 65/368 (17%)
Query: 405 FNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVP-RFLMCNLAFADFCM 463
F E ++ FL V+ L+A+LGN+ V++ + + + + +LAFAD +
Sbjct: 14 FGSVEKVVLLTFLSTVI----LMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV 69
Query: 464 GMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI 523
+ ++ +++L Y C V + S++ L I+L+R+YAI
Sbjct: 70 SVLVMPFGAIELVQDIWIYGEVF-------CLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 524 TFAMRLDRKIRLRHACAIMVGG-WVCCFLLALLPLV-GISSYAKVSICLPMDTETPLALA 581
+ R A+M+GG WV ++ LP++ G ++ + +
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 582 YIVFV------LTLNIVAFVI----VCCCYVKIYITVR--------------NPQYNPGD 617
Y VF+ +T ++VAF I + Y +IY+T + + + P
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS 242
Query: 618 KD----------TKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFY 667
D TK AK + +++ +C AP F+ + + P I + + F
Sbjct: 243 ADQHSTHRMRTETKAAKTLCIIMGCFCLCWAP--FFVTNIV--DPFIDYTVPGQVWTAFL 298
Query: 668 PL---NSCANPFLYAIFTKAFQRDVFILLSKFGIC---KRQAQAYRGQRVPPKNSTDIQV 721
L NS NPFLYA K+F+R I+L C + + + GQ VP +T +
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIIL----CCDDERYRRPSILGQTVPCSTTT---I 351
Query: 722 QKVTHEMR 729
TH +R
Sbjct: 352 NGSTHVLR 359
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 68.9 bits (167), Expect = 2e-11
Identities = 86/368 (23%), Positives = 152/368 (41%), Gaps = 65/368 (17%)
Query: 405 FNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVP-RFLMCNLAFADFCM 463
F E ++ FL V+ L+A+LGN+ V++ + + + + +LAFAD +
Sbjct: 14 FGSVEKVVLLTFLSTVI----LMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV 69
Query: 464 GMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI 523
+ ++ +++L Y C V + S++ L I+L+R+YAI
Sbjct: 70 SVLVMPFGAIELVQDIWIYGEVF-------CLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 524 TFAMRLDRKIRLRHACAIMVGG-WVCCFLLALLPLV-GISSYAKVSICLPMDTETPLALA 581
+ R A+M+GG WV ++ LP++ G ++ + +
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 582 YIVFV------LTLNIVAFVI----VCCCYVKIYITVR--------------NPQYNPGD 617
Y VF+ +T ++VAF I + Y +IY+T + + + P
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS 242
Query: 618 KD----------TKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFY 667
D TK AK + +++ +C AP F+ + + P I + + F
Sbjct: 243 ADQHSTHRMRTETKAAKTLCIIMGCFCLCWAP--FFVTNIV--DPFIDYTVPGQVWTAFL 298
Query: 668 PL---NSCANPFLYAIFTKAFQRDVFILLSKFGIC---KRQAQAYRGQRVPPKNSTDIQV 721
L NS NPFLYA K+F+R I+L C + + + GQ VP +T +
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIIL----CCDDERYRRPSILGQTVPCSTTT---I 351
Query: 722 QKVTHEMR 729
TH +R
Sbjct: 352 NGSTHVLR 359
>gi|7669548 tachykinin receptor 3 [Homo sapiens]
Length = 465
Score = 68.9 bits (167), Expect = 2e-11
Identities = 79/295 (26%), Positives = 127/295 (43%), Gaps = 40/295 (13%)
Query: 418 RIVVW-----FVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIAS 472
RI +W V +A+LGN+ V+ I+L V + + NLAF+D M + L+
Sbjct: 84 RIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNF 143
Query: 473 VDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRK 532
+ HSE+Y A C FF + A S+Y++T I ++R+ AI + K
Sbjct: 144 I-YALHSEWYFGA------NYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPL----K 192
Query: 533 IRL-RHACAIMVGG-WVCCFLLALLPLVGISSYAKV----SICLPMDTETPLA--LAYIV 584
RL A I++G W+ FLLA + S KV ++C E P +I+
Sbjct: 193 PRLSATATKIVIGSIWILAFLLAFPQC--LYSKTKVMPGRTLCFVQWPEGPKQHFTYHII 250
Query: 585 FVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGD----------KDTKIAKRMAVLIFTDF 634
++ + +I+ Y + IT+ + PGD K+ K M +++ T
Sbjct: 251 VIILVYCFPLLIMGITYTIVGITLWGGEI-PGDTCDKYHEQLKAKRKVVKMMIIVVMTFA 309
Query: 635 ICMAPISFY-ALSAILNKPLITVSNSKILLVLFYPLNSCA--NPFLYAIFTKAFQ 686
IC P Y L+AI + ++ L F+ S NP +Y K F+
Sbjct: 310 ICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 364
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 67.8 bits (164), Expect = 4e-11
Identities = 77/329 (23%), Positives = 137/329 (41%), Gaps = 55/329 (16%)
Query: 405 FNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVP-RFLMCNLAFADFCM 463
F E ++ FL V+ L+A+LGN+ V++ + + + + +LAFAD +
Sbjct: 14 FGSVEKVVLLTFLSTVI----LMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLV 69
Query: 464 GMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAI 523
+ ++ +++L Y C V + S++ L I+L+R+YAI
Sbjct: 70 SVLVMPFGAIELVQDIWIYGEVF-------CLVRTSLDVLLTTASIFHLCCISLDRYYAI 122
Query: 524 TFAMRLDRKIRLRHACAIMVGG-WVCCFLLALLPLV-GISSYAKVSICLPMDTETPLALA 581
+ R A+M+GG WV ++ LP++ G ++ + +
Sbjct: 123 CCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNST 182
Query: 582 YIVFV------LTLNIVAFVI----VCCCYVKIYITVR--------------NPQYNPGD 617
Y VF+ +T ++VAF I + Y +IY+T + + + P
Sbjct: 183 YCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQS 242
Query: 618 KD----------TKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFY 667
D TK AK + +++ +C AP F+ + + P I + + F
Sbjct: 243 ADQHSTHRMRTETKAAKTLCIIMGCFCLCWAP--FFVTNIV--DPFIDYTVPGQVWTAFL 298
Query: 668 PL---NSCANPFLYAIFTKAFQRDVFILL 693
L NS NPFLYA K+F+R I+L
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIIL 327
>gi|215272321 chemokine-like receptor 1 isoform a [Homo sapiens]
Length = 373
Score = 67.0 bits (162), Expect = 6e-11
Identities = 80/318 (25%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 403 DEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFC 462
++ +P E + FL +V V L +LGN V++I T K V NLA ADF
Sbjct: 29 EDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIA-TFKMKKTVNMVWFLNLAVADFL 87
Query: 463 MGMYLLLIASVDLYTHSEYYNHAIDWQTGPG-CNTAGFFTVFASELSVYTLTVITLERWY 521
++L + H Y W G C + F + SV+ LT+I+ +R
Sbjct: 88 FNVFLPI--------HITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCI 139
Query: 522 AITFAM--RLDRKIRLRHACAIMVGGWVCCFLLALLPLV---------GISSYAKVSICL 570
++ + + R +RL + +++ WV F L+ LV IS + S+
Sbjct: 140 SVLLPVWSQNHRSVRLAYMACMVI--WVLAFFLSSPSLVFRDTANLHGKISCFNNFSLST 197
Query: 571 PMDTETPLALA--------YIVFVLTLNIVAFVIVCCCYVKIYIT-VRNPQYNPGDKDTK 621
P + P ++V +T + F++ Y+T V Q N K K
Sbjct: 198 PGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKK 257
Query: 622 IAKRMAVLIFTDFICMAPISFYALSAI-LNKPLITVSNSKILLVLFYPL---NSCANPFL 677
K + +I T F+C P ++ L+ + L+ + S + L L L NSC NP L
Sbjct: 258 PFKIIVTIIITFFLCWCP--YHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPIL 315
Query: 678 YAIFTKAFQRDVFILLSK 695
Y + F++ L S+
Sbjct: 316 YVFMGQDFKKFKVALFSR 333
>gi|215272319 chemokine-like receptor 1 isoform a [Homo sapiens]
Length = 373
Score = 67.0 bits (162), Expect = 6e-11
Identities = 80/318 (25%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 403 DEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFC 462
++ +P E + FL +V V L +LGN V++I T K V NLA ADF
Sbjct: 29 EDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIA-TFKMKKTVNMVWFLNLAVADFL 87
Query: 463 MGMYLLLIASVDLYTHSEYYNHAIDWQTGPG-CNTAGFFTVFASELSVYTLTVITLERWY 521
++L + H Y W G C + F + SV+ LT+I+ +R
Sbjct: 88 FNVFLPI--------HITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCI 139
Query: 522 AITFAM--RLDRKIRLRHACAIMVGGWVCCFLLALLPLV---------GISSYAKVSICL 570
++ + + R +RL + +++ WV F L+ LV IS + S+
Sbjct: 140 SVLLPVWSQNHRSVRLAYMACMVI--WVLAFFLSSPSLVFRDTANLHGKISCFNNFSLST 197
Query: 571 PMDTETPLALA--------YIVFVLTLNIVAFVIVCCCYVKIYIT-VRNPQYNPGDKDTK 621
P + P ++V +T + F++ Y+T V Q N K K
Sbjct: 198 PGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKK 257
Query: 622 IAKRMAVLIFTDFICMAPISFYALSAI-LNKPLITVSNSKILLVLFYPL---NSCANPFL 677
K + +I T F+C P ++ L+ + L+ + S + L L L NSC NP L
Sbjct: 258 PFKIIVTIIITFFLCWCP--YHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPIL 315
Query: 678 YAIFTKAFQRDVFILLSK 695
Y + F++ L S+
Sbjct: 316 YVFMGQDFKKFKVALFSR 333
>gi|215272317 chemokine-like receptor 1 isoform a [Homo sapiens]
Length = 373
Score = 67.0 bits (162), Expect = 6e-11
Identities = 80/318 (25%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 403 DEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFC 462
++ +P E + FL +V V L +LGN V++I T K V NLA ADF
Sbjct: 29 EDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIA-TFKMKKTVNMVWFLNLAVADFL 87
Query: 463 MGMYLLLIASVDLYTHSEYYNHAIDWQTGPG-CNTAGFFTVFASELSVYTLTVITLERWY 521
++L + H Y W G C + F + SV+ LT+I+ +R
Sbjct: 88 FNVFLPI--------HITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCI 139
Query: 522 AITFAM--RLDRKIRLRHACAIMVGGWVCCFLLALLPLV---------GISSYAKVSICL 570
++ + + R +RL + +++ WV F L+ LV IS + S+
Sbjct: 140 SVLLPVWSQNHRSVRLAYMACMVI--WVLAFFLSSPSLVFRDTANLHGKISCFNNFSLST 197
Query: 571 PMDTETPLALA--------YIVFVLTLNIVAFVIVCCCYVKIYIT-VRNPQYNPGDKDTK 621
P + P ++V +T + F++ Y+T V Q N K K
Sbjct: 198 PGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKK 257
Query: 622 IAKRMAVLIFTDFICMAPISFYALSAI-LNKPLITVSNSKILLVLFYPL---NSCANPFL 677
K + +I T F+C P ++ L+ + L+ + S + L L L NSC NP L
Sbjct: 258 PFKIIVTIIITFFLCWCP--YHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPIL 315
Query: 678 YAIFTKAFQRDVFILLSK 695
Y + F++ L S+
Sbjct: 316 YVFMGQDFKKFKVALFSR 333
>gi|4758014 chemokine-like receptor 1 isoform b [Homo sapiens]
Length = 371
Score = 67.0 bits (162), Expect = 6e-11
Identities = 80/318 (25%), Positives = 131/318 (41%), Gaps = 38/318 (11%)
Query: 403 DEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFC 462
++ +P E + FL +V V L +LGN V++I T K V NLA ADF
Sbjct: 27 EDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIA-TFKMKKTVNMVWFLNLAVADFL 85
Query: 463 MGMYLLLIASVDLYTHSEYYNHAIDWQTGPG-CNTAGFFTVFASELSVYTLTVITLERWY 521
++L + H Y W G C + F + SV+ LT+I+ +R
Sbjct: 86 FNVFLPI--------HITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCI 137
Query: 522 AITFAM--RLDRKIRLRHACAIMVGGWVCCFLLALLPLV---------GISSYAKVSICL 570
++ + + R +RL + +++ WV F L+ LV IS + S+
Sbjct: 138 SVLLPVWSQNHRSVRLAYMACMVI--WVLAFFLSSPSLVFRDTANLHGKISCFNNFSLST 195
Query: 571 PMDTETPLALA--------YIVFVLTLNIVAFVIVCCCYVKIYIT-VRNPQYNPGDKDTK 621
P + P ++V +T + F++ Y+T V Q N K K
Sbjct: 196 PGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKK 255
Query: 622 IAKRMAVLIFTDFICMAPISFYALSAI-LNKPLITVSNSKILLVLFYPL---NSCANPFL 677
K + +I T F+C P ++ L+ + L+ + S + L L L NSC NP L
Sbjct: 256 PFKIIVTIIITFFLCWCP--YHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPIL 313
Query: 678 YAIFTKAFQRDVFILLSK 695
Y + F++ L S+
Sbjct: 314 YVFMGQDFKKFKVALFSR 331
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,990,314
Number of Sequences: 37866
Number of extensions: 1231822
Number of successful extensions: 4922
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 436
Number of HSP's that attempted gapping in prelim test: 4257
Number of HSP's gapped (non-prelim): 754
length of query: 764
length of database: 18,247,518
effective HSP length: 110
effective length of query: 654
effective length of database: 14,082,258
effective search space: 9209796732
effective search space used: 9209796732
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.