BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo sapiens] (655 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 1295 0.0 gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 265 1e-70 gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 263 5e-70 gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 263 5e-70 gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 261 1e-69 gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 261 1e-69 gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 261 1e-69 gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 261 1e-69 gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 261 1e-69 gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 249 7e-66 gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 236 4e-62 gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 92 2e-18 gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 86 1e-16 gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 83 9e-16 gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 81 3e-15 gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 80 5e-15 gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 80 6e-15 gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 80 6e-15 gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 77 5e-14 gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 77 7e-14 gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 76 9e-14 gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 75 1e-13 gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 75 1e-13 gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 75 2e-13 gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 74 3e-13 gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 74 6e-13 gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 74 6e-13 gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 71 4e-12 gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 70 8e-12 gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 68 2e-11 >gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo sapiens] Length = 655 Score = 1295 bits (3352), Expect = 0.0 Identities = 655/655 (100%), Positives = 655/655 (100%) Query: 1 MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE 60 MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE Sbjct: 1 MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE 60 Query: 61 KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120 KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN Sbjct: 61 KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120 Query: 121 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT 180 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT Sbjct: 121 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT 180 Query: 181 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF 240 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF Sbjct: 181 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF 240 Query: 241 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING 300 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING Sbjct: 241 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING 300 Query: 301 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK 360 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK Sbjct: 301 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK 360 Query: 361 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS 420 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS Sbjct: 361 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS 420 Query: 421 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP Sbjct: 421 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480 Query: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL 540 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL Sbjct: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL 540 Query: 541 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN 600 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN Sbjct: 541 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN 600 Query: 601 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS Sbjct: 601 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655 >gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4 [Homo sapiens] Length = 678 Score = 265 bits (677), Expect = 1e-70 Identities = 163/529 (30%), Positives = 294/529 (55%), Gaps = 21/529 (3%) Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114 RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR Sbjct: 93 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 151 Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173 F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL Sbjct: 152 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 209 Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233 A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++ Sbjct: 210 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 264 Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293 GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF Sbjct: 265 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 324 Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKL-AEIYVNSSFYKETKAELHQL 352 +++ +G+ +++ + + D L + VN + E+ Q Sbjct: 325 VMEVASGE------YGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQT 378 Query: 353 S--GGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIG 410 G +K ++ S++ S Q + KR+F +++ + + +I + +GL+IG Sbjct: 379 KRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIG 438 Query: 411 AIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSY 469 +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +Y Sbjct: 439 LLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAY 498 Query: 470 FLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAA 529 +L K ++D +P +++ + + IVY+M A F + M + A S+ L I A Sbjct: 499 YLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA 557 Query: 530 GQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578 + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF Sbjct: 558 ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 606 >gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo sapiens] Length = 646 Score = 263 bits (671), Expect = 5e-70 Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%) Query: 54 PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111 PC RK K +L ++G + L I+GP+G GKS+ +++LA ++ SG+ G +L+NG Sbjct: 74 PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132 Query: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170 PR F+ S Y++QDD+++ LTV E + SA L+L+ K E + ++ LGL Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190 Query: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230 + ++ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K Sbjct: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245 Query: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290 +++ GRTII +IHQP +F++FD L +L+ G+ +F G + Y + G HC Y+NP Sbjct: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305 Query: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350 ADF +++ +G+ + P++ + + + + K++ E + Sbjct: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345 Query: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408 ++ ++ + ++ TS Q + KR+F ++L + + + + VV+G++ Sbjct: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405 Query: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467 IG +Y + +D++ + N G LFF F+++ L F +E +F+ E+++ +Y + Sbjct: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465 Query: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527 +Y+L K ++D +P +++ +++ IVY+M G + F + A A S+ L I Sbjct: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524 Query: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587 A + + VAT + + + +++FSG V+ TI ++L W Y S RYGF + + Sbjct: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583 Query: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646 G+ G+ C C E + + +D+ L+ + + L + +AYL Sbjct: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636 Query: 647 KLLFLKK 653 L + K Sbjct: 637 VLRYRVK 643 >gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sapiens] Length = 646 Score = 263 bits (671), Expect = 5e-70 Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%) Query: 54 PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111 PC RK K +L ++G + L I+GP+G GKS+ +++LA ++ SG+ G +L+NG Sbjct: 74 PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132 Query: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170 PR F+ S Y++QDD+++ LTV E + SA L+L+ K E + ++ LGL Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190 Query: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230 + ++ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K Sbjct: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245 Query: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290 +++ GRTII +IHQP +F++FD L +L+ G+ +F G + Y + G HC Y+NP Sbjct: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305 Query: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350 ADF +++ +G+ + P++ + + + + K++ E + Sbjct: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345 Query: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408 ++ ++ + ++ TS Q + KR+F ++L + + + + VV+G++ Sbjct: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405 Query: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467 IG +Y + +D++ + N G LFF F+++ L F +E +F+ E+++ +Y + Sbjct: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465 Query: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527 +Y+L K ++D +P +++ +++ IVY+M G + F + A A S+ L I Sbjct: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524 Query: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587 A + + VAT + + + +++FSG V+ TI ++L W Y S RYGF + + Sbjct: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583 Query: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646 G+ G+ C C E + + +D+ L+ + + L + +AYL Sbjct: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636 Query: 647 KLLFLKK 653 L + K Sbjct: 637 VLRYRVK 643 >gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7 [Homo sapiens] Length = 663 Score = 261 bits (667), Expect = 1e-69 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%) Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114 RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR Sbjct: 90 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 148 Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173 F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL Sbjct: 149 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 206 Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233 A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++ Sbjct: 207 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 261 Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293 GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF Sbjct: 262 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 321 Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351 +++ +G E Q+ L+ + E +S ++ AE++ Sbjct: 322 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 362 Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409 ++ + E S++ S Q + KR+F +++ + + +I + +GL+I Sbjct: 363 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 422 Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468 G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + + Sbjct: 423 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 482 Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528 Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I Sbjct: 483 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 541 Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578 A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF Sbjct: 542 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 591 >gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6 [Homo sapiens] Length = 644 Score = 261 bits (667), Expect = 1e-69 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%) Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114 RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR Sbjct: 71 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 129 Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173 F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL Sbjct: 130 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 187 Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233 A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++ Sbjct: 188 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 242 Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293 GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF Sbjct: 243 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 302 Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351 +++ +G E Q+ L+ + E +S ++ AE++ Sbjct: 303 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 343 Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409 ++ + E S++ S Q + KR+F +++ + + +I + +GL+I Sbjct: 344 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 403 Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468 G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + + Sbjct: 404 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 463 Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528 Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I Sbjct: 464 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 522 Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578 A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF Sbjct: 523 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 572 >gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5 [Homo sapiens] Length = 668 Score = 261 bits (667), Expect = 1e-69 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%) Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114 RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR Sbjct: 95 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 153 Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173 F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL Sbjct: 154 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 211 Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233 A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++ Sbjct: 212 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 266 Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293 GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF Sbjct: 267 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 326 Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351 +++ +G E Q+ L+ + E +S ++ AE++ Sbjct: 327 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 367 Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409 ++ + E S++ S Q + KR+F +++ + + +I + +GL+I Sbjct: 368 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 427 Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468 G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + + Sbjct: 428 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 487 Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528 Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I Sbjct: 488 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 546 Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578 A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF Sbjct: 547 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 596 >gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3 [Homo sapiens] Length = 677 Score = 261 bits (667), Expect = 1e-69 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%) Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114 RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR Sbjct: 104 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 162 Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173 F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL Sbjct: 163 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 220 Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233 A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++ Sbjct: 221 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 275 Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293 GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF Sbjct: 276 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 335 Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351 +++ +G E Q+ L+ + E +S ++ AE++ Sbjct: 336 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 376 Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409 ++ + E S++ S Q + KR+F +++ + + +I + +GL+I Sbjct: 377 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 436 Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468 G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + + Sbjct: 437 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 496 Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528 Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I Sbjct: 497 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 555 Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578 A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF Sbjct: 556 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 605 >gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2 [Homo sapiens] Length = 666 Score = 261 bits (667), Expect = 1e-69 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%) Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114 RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR Sbjct: 93 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 151 Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173 F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL Sbjct: 152 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 209 Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233 A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++ Sbjct: 210 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 264 Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293 GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF Sbjct: 265 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 324 Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351 +++ +G E Q+ L+ + E +S ++ AE++ Sbjct: 325 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 365 Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409 ++ + E S++ S Q + KR+F +++ + + +I + +GL+I Sbjct: 366 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 425 Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468 G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + + Sbjct: 426 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 485 Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528 Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I Sbjct: 486 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 544 Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578 A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF Sbjct: 545 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 594 >gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sapiens] Length = 651 Score = 249 bits (635), Expect = 7e-66 Identities = 179/611 (29%), Positives = 317/611 (51%), Gaps = 47/611 (7%) Query: 13 SQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMK 72 SQ + G PATA + + G + + +++ +RV+ CR+ ++IL +++ ++ Sbjct: 21 SQSSLEGAPATAP---EPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVE 77 Query: 73 PG-LNAILGPTGGGKSSLLDVLAARKDPSG-LSGDVLING-APRPANFKCNSGYVVQDDV 129 G + ILG +G GK++LLD ++ R +G G+V +NG A R F+ YV+Q D Sbjct: 78 SGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDT 137 Query: 130 VMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGG 189 ++ +LTVRE L ++A L + + +++ V+ EL L VAD +G + G+S G Sbjct: 138 LLSSLTVRETLHYTALLAIRRGNPGSFQ-KKVEAVMAELSLSHVADRLIGNYSLGGISTG 196 Query: 190 ERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSI 249 ER+R SI +L+ DP ++ DEPTTGLD TAN +++LL ++++ R ++ +IHQPR + Sbjct: 197 ERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSEL 256 Query: 250 FKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNR 309 F+LFD + +L+ G L+F G E L +F GY C ++NP DF++D+ + D+ ++ Sbjct: 257 FQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQ----SK 312 Query: 310 EEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISY 369 E + IE SK+ ++ + Y S+ +T L E+ K + + + Sbjct: 313 ERE------IETSKR----VQMIESAYKKSAICHKT------LKNIERMKHLKTLPMVPF 356 Query: 370 TT----SFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDST---- 421 T +L + +R +NL+ N A I +++ +++GL + ++F L+ S Sbjct: 357 KTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFL--LFFVLRVRSNVLKG 414 Query: 422 GIQNRAGVLF-FLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480 IQ+R G+L+ F+ ++AV LF V + + E G Y+ L L +LP Sbjct: 415 AIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYAL-HVLP 473 Query: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLM---MVAYSASSMALAIAAGQSVVSVA 537 ++ ++IF+ + Y+ LGL P+ F L+ ++ + + L I ++V+ Sbjct: 474 FSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSV 533 Query: 538 TLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPG--- 594 L++I V ++ SG L N+ + + YF+ +Y L NEF G NF G Sbjct: 534 VALLSIAGV--LVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSN 591 Query: 595 LNATGNNPCNY 605 ++ T N C + Sbjct: 592 VSVTTNPMCAF 602 >gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sapiens] Length = 673 Score = 236 bits (603), Expect = 4e-62 Identities = 166/585 (28%), Positives = 289/585 (49%), Gaps = 27/585 (4%) Query: 77 AILGPTGGGKSSLLDVLAARKDPSGL-SGDVLINGAPRPANF--KCNSGYVVQDDVVMGT 133 AI+G +G G++SLLDV+ R + SG + ING P KC + +V Q + ++ Sbjct: 102 AIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVA-HVRQHNQLLPN 160 Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193 LTVRE L F A +RL T + ++++R+ VI EL L + AD++VG ++RG+SGGER+R Sbjct: 161 LTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRR 220 Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253 SIG++L+ +P IL LDEPT+GLDS TA+ ++ L R++K R ++ S+HQPR IF+LF Sbjct: 221 VSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLF 280 Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDF 313 D + L+ SG ++ G AQ + YF + GY C Y+NPADF++D+ + D +RE++ Sbjct: 281 DLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR----SREQEL 336 Query: 314 KATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQ---LSGGEKKKKITVFKEISYT 370 E + +EK+ ++ + +K +L + + + Sbjct: 337 ATRE--KAQSLAALFLEKVRDL--DDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKM 392 Query: 371 TSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVL 430 Q + +R N + + ++ + IG +YFG + + A +L Sbjct: 393 PGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALL 452 Query: 431 FFLTTNQCFSSV-SAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIF 489 F + F+ + + E+ + +E G Y YF K+L + LP II+ Sbjct: 453 FMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGE-LPEHCAYIIIY 511 Query: 490 TCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMM 549 Y++ L+P F + + +V + MALA AA +A+ + Sbjct: 512 GMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFY 571 Query: 550 IFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNF-CPGLNATGNNPCNYATC 608 + G ++NL+++ + +W+ S R+ F L +F + + P N T Sbjct: 572 LAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLT-------IAV 624 Query: 609 TGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKK 653 +G++ L +D P L+ ++ + + F+ + Y+ L F+K+ Sbjct: 625 SGDKILSVMELDSYP--LYAIYLIVIGLSGGFMVLYYVSLRFIKQ 667 >gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo sapiens] Length = 1624 Score = 92.0 bits (227), Expect = 2e-18 Identities = 57/170 (33%), Positives = 95/170 (55%), Gaps = 12/170 (7%) Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA---NFKCNSGYVVQDDVVM 131 + A+LG +G GK++LL++L+ P+ S V + R A N +G+ Q +V Sbjct: 512 ITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQF 571 Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191 G LTV+ENL+ A ++ + HE + + RV+QEL ++ + D + +SGG+ Sbjct: 572 GFLTVKENLRLFAKIK---GILPHEVEKEVQRVVQELEMENIQDI-----LAQNLSGGQN 623 Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241 ++ + G+ ++ DP +L LDEPT GLD + + + LLK K R I+FS Sbjct: 624 RKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSDRVILFS 672 Score = 58.5 bits (140), Expect = 2e-08 Identities = 57/238 (23%), Positives = 110/238 (46%), Gaps = 21/238 (8%) Query: 44 YRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGL 102 Y K K+ F +K + N++ +K G + +LG G GKS+ + ++ P+ Sbjct: 1292 YAGKKKNCFSKRKKKIATR---NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPT-- 1346 Query: 103 SGDVLINGAP--RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER 160 +G V++ G+ P F GY Q++ + LTVR++L+ AA++ + + Sbjct: 1347 AGQVILKGSGGGEPLGFL---GYCPQENALWPNLTVRQHLEVYAAVK---GLRKGDAMIA 1400 Query: 161 INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSST 220 I R++ L L + V T +S G +++ + ++ +PS++ LDEP+TG+D Sbjct: 1401 ITRLVDALKLQDQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEG 1455 Query: 221 ANAVLLLLKRMSKQ-GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277 + +++ + R + + H + D + ++ SGRL G Q F Sbjct: 1456 QQQMWQVIRATFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1512 >gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13 [Homo sapiens] Length = 5058 Score = 85.9 bits (211), Expect = 1e-16 Identities = 58/198 (29%), Positives = 108/198 (54%), Gaps = 13/198 (6%) Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131 + A+LG G GK++++ +L P+ SG ++ING + + G Q D+++ Sbjct: 3870 ITALLGTNGAGKTTIISMLTGLHPPT--SGTIIINGKNLQTDLSRVRMELGVCPQQDILL 3927 Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191 LTVRE+L A+++ A T E ++++N+ +Q++ L + + R +SGG + Sbjct: 3928 DNLTVREHLLLFASIK-APQWTKKELHQQVNQTLQDVDLTQHQHKQT-----RALSGGLK 3981 Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251 ++ S+G+ + + LDEPT+G+D + +++ +L + ++GRTIIF+ H Sbjct: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKY-REGRTIIFTTHH-LDEAEA 4039 Query: 252 LFDSLTLLASGRLMFHGP 269 L D + +L GRL GP Sbjct: 4040 LSDRVAVLQHGRLRCCGP 4057 Score = 51.6 bits (122), Expect = 2e-06 Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 17/182 (9%) Query: 69 GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSG------ 122 GI K +LG G GKS+ +L + S SG +I A ++G Sbjct: 4743 GIPKGECFGLLGVNGAGKSTTFKMLNG--EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI 4800 Query: 123 -YVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQ 181 Y Q D + LT E+L + +LR + E +I+ L L+ AD V T Sbjct: 4801 GYCPQQDALDELLTGWEHLYYYCSLR---GIPRQCIPEVAGDLIRRLHLEAHADKPVATY 4857 Query: 182 FIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241 SGG +++ S + L+ P IL LDEP++G+D + + + + ++G + + Sbjct: 4858 -----SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912 Query: 242 IH 243 H Sbjct: 4913 SH 4914 >gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo sapiens] Length = 1704 Score = 82.8 bits (203), Expect = 9e-16 Identities = 69/225 (30%), Positives = 113/225 (50%), Gaps = 20/225 (8%) Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVM 131 + +LG G GK++ L +L P+ SG I+G + + + G Q D++ Sbjct: 561 ITVLLGHNGAGKTTTLSMLTGLFPPT--SGRAYISGYEISQDMVQIRKSLGLCPQHDILF 618 Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191 LTV E+L F A L+ ++ + E + +++ +GL+ +S+ R +SGG R Sbjct: 619 DNLTVAEHLYFYAQLK---GLSRQKCPEEVKQMLHIIGLEDKWNSRS-----RFLSGGMR 670 Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251 ++ SIG+ LI +L LDEPT+G+D+ + A+ LL+R K RTI+ + H + Sbjct: 671 RKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADL- 728 Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHC----EAYNNPAD 292 L D + ++A G L G + L AGYH E + NP D Sbjct: 729 LGDRIAIMAKGELQCCG-SSLFLKQKYGAGYHMTLVKEPHCNPED 772 Score = 66.2 bits (160), Expect = 9e-11 Identities = 57/212 (26%), Positives = 94/212 (44%), Gaps = 15/212 (7%) Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134 +LG G GK++ +L + S SGD + G + + GY Q D ++ + Sbjct: 1414 LLGFNGAGKTTTFKMLTGEE--SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHM 1471 Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194 T RE L A LR + + ++ L L+ A+ + +R SGG +++ Sbjct: 1472 TGREMLVMYARLR---GIPERHIGACVENTLRGLLLEPHAN-----KLVRTYSGGNKRKL 1523 Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254 S G+ LI +P+++FLDEP+TG+D + + R + G+ II + H L Sbjct: 1524 STGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSME-ECEALCT 1582 Query: 255 SLTLLASGRLMFHGPAQEALGYFESAGYHCEA 286 L ++ G+ G Q F S GY A Sbjct: 1583 RLAIMVQGQFKCLGSPQHLKSKFGS-GYSLRA 1613 >gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo sapiens] Length = 1543 Score = 80.9 bits (198), Expect = 3e-15 Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 14/218 (6%) Query: 75 LNAILGPTGGGKSSLLDVLAARK---DPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVM 131 + AILG G GKS+LL++L+ + S + ++ + N G+ Q + Sbjct: 422 ITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQF 481 Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191 LTVRENL+ A ++ + E + + R+I EL + + D + +SGG++ Sbjct: 482 DFLTVRENLRVFAKIK---GIQPKEVEQEVKRIIMELDMQSIQDI-----IAKKLSGGQK 533 Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251 ++ ++G+ ++ DP +L LDEPT GLD + + V LLK K R I+FS Q Sbjct: 534 RKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRLILFST-QFMDEADI 591 Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289 L D L++G+L G + L GYH + N Sbjct: 592 LADRKVFLSNGKLKCAG-SSLFLKRKWGIGYHLSLHRN 628 Score = 55.1 bits (131), Expect = 2e-07 Identities = 57/245 (23%), Positives = 115/245 (46%), Gaps = 22/245 (8%) Query: 40 HNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKD 98 H Y K KS F +K + + N++ +K G + +LG G GKS+ + ++ Sbjct: 1202 HKEYYETK-KSCFSTRKKKIA---IRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTK 1257 Query: 99 PSGLSGDVLINGAPRPANFKCNS-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMT 153 P+ +G V++ G+ + ++ GY Q++ + LT++E+L+ AA++ + Sbjct: 1258 PT--AGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVK---GLG 1312 Query: 154 NHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPT 213 + I+R+++ L L + + V T +S G +++ + ++ +PS++ LDEP Sbjct: 1313 KEDAALSISRLVEALKLQEQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPF 1367 Query: 214 TGLDSSTANAVLLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQE 272 TG+D + +L+ K + R + + H + D + ++ SG L G Q Sbjct: 1368 TGMDPEGQQQMWQILQATVKNKERGTLLTTHY-MSEAEAVCDRMAMMVSGTLRCIGSIQH 1426 Query: 273 ALGYF 277 F Sbjct: 1427 LKNKF 1431 >gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo sapiens] Length = 2146 Score = 80.5 bits (197), Expect = 5e-15 Identities = 60/208 (28%), Positives = 99/208 (47%), Gaps = 15/208 (7%) Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134 +LG G GK+S ++ D G+ ++ G A P+ + GY Q D + L Sbjct: 1825 LLGVNGAGKTSTFRMVTG--DTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882 Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194 T RE+L+ A LR + + + + LGL AD GT SGG +++ Sbjct: 1883 TGREHLELLARLR---GVPEAQVAQTAGSGLARLGLSWYADRPAGTY-----SGGNKRKL 1934 Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254 + + L+ DP+++FLDEPTTG+D S + L + ++GR+++ + H L Sbjct: 1935 ATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSME-ECEALCS 1993 Query: 255 SLTLLASGRLMFHGPAQEALGYFESAGY 282 L ++ +GR G Q G F +AG+ Sbjct: 1994 RLAIMVNGRFRCLGSPQHLKGRF-AAGH 2020 Score = 72.0 bits (175), Expect = 2e-12 Identities = 58/192 (30%), Positives = 102/192 (53%), Gaps = 13/192 (6%) Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP-ANFKCNSGYVVQDDVVMGT 133 + A LG G GK++ L +L+ PSG S +L + A + + G Q +V+ Sbjct: 836 ITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDM 895 Query: 134 LTVRENLQFSAALR-LATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERK 192 LTV E++ F L+ L+ + E++ R++Q++GL V+ V T R +SGG ++ Sbjct: 896 LTVDEHVWFYGRLKGLSAAVVGPEQD----RLLQDVGL--VSKQSVQT---RHLSGGMQR 946 Query: 193 RTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKL 252 + S+ + + ++ LDEPT G+D ++ + LL + ++GRT+I S H + L Sbjct: 947 KLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKY-REGRTLILSTHHLDEAEL-L 1004 Query: 253 FDSLTLLASGRL 264 D + ++A GRL Sbjct: 1005 GDRVAVVAGGRL 1016 >gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a [Homo sapiens] Length = 2436 Score = 80.1 bits (196), Expect = 6e-15 Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%) Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134 +LG G GK+S +L D S G+ +NG + + GY Q D + L Sbjct: 2086 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2143 Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194 T RE+LQ LR ++ ++ + +++L L K AD GT SGG +++ Sbjct: 2144 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2195 Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254 S + LI P+ +FLDEPTTG+D + L+ + K GR+++ + H L Sbjct: 2196 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2254 Query: 255 SLTLLASGRLMFHGPAQEALGYF 277 L ++ +GRL G Q F Sbjct: 2255 RLAIMVNGRLRCLGSIQHLKNRF 2277 Score = 70.1 bits (170), Expect = 6e-12 Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%) Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133 + LG G GK++ + +L P+ SG I G + N G Q +V+ Sbjct: 1022 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1079 Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193 LTV E+L F + L+ +M E ++++I++L L S V T +SGG +++ Sbjct: 1080 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1131 Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253 S+ + + + LDEPT G+D A+ L+ + K GRTI+ S H + L Sbjct: 1132 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1189 Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292 D + +++ G+L G G + GY PA+ Sbjct: 1190 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1227 >gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b [Homo sapiens] Length = 2466 Score = 80.1 bits (196), Expect = 6e-15 Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%) Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134 +LG G GK+S +L D S G+ +NG + + GY Q D + L Sbjct: 2116 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2173 Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194 T RE+LQ LR ++ ++ + +++L L K AD GT SGG +++ Sbjct: 2174 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2225 Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254 S + LI P+ +FLDEPTTG+D + L+ + K GR+++ + H L Sbjct: 2226 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2284 Query: 255 SLTLLASGRLMFHGPAQEALGYF 277 L ++ +GRL G Q F Sbjct: 2285 RLAIMVNGRLRCLGSIQHLKNRF 2307 Score = 70.1 bits (170), Expect = 6e-12 Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%) Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133 + LG G GK++ + +L P+ SG I G + N G Q +V+ Sbjct: 1052 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1109 Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193 LTV E+L F + L+ +M E ++++I++L L S V T +SGG +++ Sbjct: 1110 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1161 Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253 S+ + + + LDEPT G+D A+ L+ + K GRTI+ S H + L Sbjct: 1162 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1219 Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292 D + +++ G+L G G + GY PA+ Sbjct: 1220 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1257 >gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo sapiens] Length = 1617 Score = 77.0 bits (188), Expect = 5e-14 Identities = 64/218 (29%), Positives = 105/218 (48%), Gaps = 14/218 (6%) Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131 + AILG +G GKSSLL++L P+ S + + + +G Q +V Sbjct: 509 ITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQF 568 Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191 LTV+ENL A ++ + E + + R++ EL + + D+ + +S G++ Sbjct: 569 DILTVKENLSLFAKIK---GIHLKEVEQEVQRILLELDMQNIQDN-----LAKHLSEGQK 620 Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251 ++ + G+ ++ DP IL LDEPTTGLD + + V LL R + I+FS Q Sbjct: 621 RKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL-RERRADHVILFST-QSMDEADI 678 Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289 L D ++++GRL G + L GYH + N Sbjct: 679 LADRKVIMSNGRLKCAGSSM-FLKRRWGLGYHLSLHRN 715 Score = 56.6 bits (135), Expect = 7e-08 Identities = 53/217 (24%), Positives = 106/217 (48%), Gaps = 16/217 (7%) Query: 57 KPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA 115 K +K NI+ ++ G + +LGP G GKSS + +++ P+ +G+V + G + Sbjct: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPT--AGEVELKGC---S 1350 Query: 116 NFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVAD 175 + + GY Q++V+ LT+RE+L+ AA++ + + I R++ L + + Sbjct: 1351 SVLGHLGYCPQENVLWPMLTLREHLEVYAAVK---GLRKADARLAIARLVSAFKLHEQLN 1407 Query: 176 SKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ- 234 V + ++ G ++ + L+ + +L LDEP+TG+D + + ++ + K Sbjct: 1408 VPV-----QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNT 1462 Query: 235 GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271 R ++ + H L D + ++ SGRL G Q Sbjct: 1463 ERGVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGSIQ 1498 >gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sapiens] Length = 2261 Score = 76.6 bits (187), Expect = 7e-14 Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 14/203 (6%) Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFK---CNSGYVVQDDVVMGTL 134 +LG G GKSS +L D + GD +N +N N GY Q D + L Sbjct: 1944 LLGVNGAGKSSTFKMLTG--DTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELL 2001 Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194 T RE+++F A LR + E + I++LGL K G ++ SGG +++ Sbjct: 2002 TGREHVEFFALLR---GVPEKEVGKVGEWAIRKLGL-----VKYGEKYAGNYSGGNKRKL 2053 Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254 S M LI P ++FLDEPTTG+D + + K+GR+++ + H L Sbjct: 2054 STAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSME-ECEALCT 2112 Query: 255 SLTLLASGRLMFHGPAQEALGYF 277 + ++ +GR G Q F Sbjct: 2113 RMAIMVNGRFRCLGSVQHLKNRF 2135 Score = 69.3 bits (168), Expect = 1e-11 Identities = 64/244 (26%), Positives = 109/244 (44%), Gaps = 21/244 (8%) Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP---RPANFKCNSGYVVQDDVVM 131 + + LG G GK++ + +L P+ SG I G + + N G Q +V+ Sbjct: 928 ITSFLGHNGAGKTTTMSILTGLFPPT--SGTAYILGKDIRSEMSTIRQNLGVCPQHNVLF 985 Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191 LTV E++ F A RL H K E ++++ LD S +SGG + Sbjct: 986 DMLTVEEHIWFYA--RLKGLSEKHVKAE-----MEQMALDVGLPSSKLKSKTSQLSGGMQ 1038 Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251 ++ S+ + + ++ LDEPT G+D + + LL + +QGRTII S H + Sbjct: 1039 RKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY-RQGRTIILSTHHMDEADV- 1096 Query: 252 LFDSLTLLASGRLMFHGPA---QEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALN 308 L D + +++ G+L G + + LG GY+ + L S+ V+ Sbjct: 1097 LGDRIAIISHGKLCCVGSSLFLKNQLG----TGYYLTLVKKDVESSLSSCRNSSSTVSYL 1152 Query: 309 REED 312 ++ED Sbjct: 1153 KKED 1156 >gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo sapiens] Length = 718 Score = 76.3 bits (186), Expect = 9e-14 Identities = 66/246 (26%), Positives = 119/246 (48%), Gaps = 28/246 (11%) Query: 37 LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95 ++F N+C+ + GF E+L + + PG + A++G +GGGK+++ +L Sbjct: 455 VTFQNVCFSYPCRPGF---------EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLER 505 Query: 96 RKDPSGLSGDVLINGAPR----PANFKCNS-GYVVQDDVVMGTLTVRENLQFSAALRLAT 150 DP+ +G V+++G P+ + G++ Q+ V+ GT T+ EN++F Sbjct: 506 FYDPT--AGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT-TIMENIRFGKLEASDE 562 Query: 151 TMTNHEKNERINRVIQEL--GLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILF 208 + + + I G + V + T +SGG+++R +I LI P++L Sbjct: 563 EVYTAAREANAHEFITSFPEGYNTVVGERGTT-----LSGGQKQRLAIARALIKQPTVLI 617 Query: 209 LDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG 268 LDE T+ LD+ + V L R S GRT++ H R S + + ++A GR+ G Sbjct: 618 LDEATSALDAESERVVQEALDRAS-AGRTVLVIAH--RLSTVRGAHCIVVMADGRVWEAG 674 Query: 269 PAQEAL 274 +E L Sbjct: 675 THEELL 680 >gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b [Homo sapiens] Length = 2277 Score = 75.5 bits (184), Expect = 1e-13 Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 21/230 (9%) Query: 61 KEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF-- 117 K + N+N G + ++LGP G GK++ + +L S +G + + G + Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS--AGTIFVYGKDIKTDLHT 1097 Query: 118 -KCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADS 176 + N G +Q DV+ LT +E+L ++++ T + +E + R +++ GL Sbjct: 1098 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRHK 1156 Query: 177 KVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR 236 +VGT +SGG +++ SI + LI ++ LDEP+TG+D + ++ ++ + +K R Sbjct: 1157 RVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTAR 1210 Query: 237 TIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGP---AQEALGYFESAGYH 283 TII S H + L D + L G L G +EA G GYH Sbjct: 1211 TIILSTHHLDEAEV-LSDRIAFLEQGGLRCCGSPFYLKEAFG----DGYH 1255 Score = 57.0 bits (136), Expect = 5e-08 Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 18/226 (7%) Query: 59 VEKEILSNIN---GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLI-NGAPRP 114 + K+I++ N GI +LG G GK+++ +L PS SG++LI N Sbjct: 1948 IHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS--SGNILIRNKTGSL 2005 Query: 115 ANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171 + +S GY Q+D + +TV E+L F A + + + E ++++++ L L Sbjct: 2006 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLM 2062 Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231 D S G +++ S + LI PSIL LDEP++G+D + + ++ Sbjct: 2063 PFKDRATSM-----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEE 2117 Query: 232 SKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277 + ++I + H L L ++ +G+ G Q F Sbjct: 2118 VQNKCSVILTSHSME-ECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2162 >gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a [Homo sapiens] Length = 2595 Score = 75.5 bits (184), Expect = 1e-13 Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 21/230 (9%) Query: 61 KEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF-- 117 K + N+N G + ++LGP G GK++ + +L S +G + + G + Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS--AGTIFVYGKDIKTDLHT 1415 Query: 118 -KCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADS 176 + N G +Q DV+ LT +E+L ++++ T + +E + R +++ GL Sbjct: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRHK 1474 Query: 177 KVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR 236 +VGT +SGG +++ SI + LI ++ LDEP+TG+D + ++ ++ + +K R Sbjct: 1475 RVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTAR 1528 Query: 237 TIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGP---AQEALGYFESAGYH 283 TII S H + L D + L G L G +EA G GYH Sbjct: 1529 TIILSTHHLDEAEV-LSDRIAFLEQGGLRCCGSPFYLKEAFG----DGYH 1573 Score = 57.0 bits (136), Expect = 5e-08 Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 18/226 (7%) Query: 59 VEKEILSNIN---GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLI-NGAPRP 114 + K+I++ N GI +LG G GK+++ +L PS SG++LI N Sbjct: 2266 IHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS--SGNILIRNKTGSL 2323 Query: 115 ANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171 + +S GY Q+D + +TV E+L F A + + + E ++++++ L L Sbjct: 2324 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLM 2380 Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231 D S G +++ S + LI PSIL LDEP++G+D + + ++ Sbjct: 2381 PFKDRATSM-----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEE 2435 Query: 232 SKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277 + ++I + H L L ++ +G+ G Q F Sbjct: 2436 VQNKCSVILTSHSME-ECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480 >gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11 [Homo sapiens] Length = 1321 Score = 75.1 bits (183), Expect = 2e-13 Identities = 87/322 (27%), Positives = 141/322 (43%), Gaps = 47/322 (14%) Query: 37 LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95 + FHN+ + P R V+ IL+++N ++KPG + A++GP+G GKS+ L ++ Sbjct: 420 IEFHNVTFHY-------PSRPEVK--ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQR 470 Query: 96 RKDPSGLSGDVLINGAP-RPANFKC---NSGYVVQDDVVMGTLTVRENLQFSAALRLATT 151 DP G V ++G R N + G V Q+ V+ T T+ EN+++ Sbjct: 471 FYDPC--EGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFST-TIAENIRYGREDATMED 527 Query: 152 MTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDE 211 + K I +L + D+ VG + +SGG+++R +I LI +P IL LD Sbjct: 528 IVQAAKEANAYNFIMDL--PQQFDTLVGEGGGQ-MSGGQKQRVAIARALIRNPKILLLDM 584 Query: 212 PTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271 T+ LD+ + V +L ++ + G TII H R S + D++ HG A Sbjct: 585 ATSALDNESEAMVQEVLSKI-QHGHTIISVAH--RLSTVRAADTIIGFE------HGTAV 635 Query: 272 EALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEK 331 E G H E +F + ALN E+ ATE + Sbjct: 636 E-------RGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATE-----------DDM 677 Query: 332 LAEIYVNSSFYKETKAELHQLS 353 LA + S+ +A + Q S Sbjct: 678 LARTFSRGSYQDSLRASIRQRS 699 Score = 65.9 bits (159), Expect = 1e-10 Identities = 60/230 (26%), Positives = 115/230 (50%), Gaps = 32/230 (13%) Query: 60 EKEILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPAN- 116 + ++L+ ++ + PG A +G +G GKS+ + +L DP G V+I+G + N Sbjct: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPD--QGKVMIDGHDSKKVNV 1149 Query: 117 --FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQE------- 167 + N G V Q+ V+ ++ +N+++ ++ K + RVI Sbjct: 1150 QFLRSNIGIVSQEPVLFAC-SIMDNIKYG----------DNTKEIPMERVIAAAKQAQLH 1198 Query: 168 ---LGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224 + L + ++ VG+Q + +S GE++R +I ++ DP IL LDE T+ LD+ + V Sbjct: 1199 DFVMSLPEKYETNVGSQGSQ-LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV 1257 Query: 225 LLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEAL 274 + L + +++GRT I H R S + D + ++A G ++ G +E + Sbjct: 1258 QVALDK-AREGRTCIVIAH--RLSTIQNADIIAVMAQGVVIEKGTHEELM 1304 >gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo sapiens] Length = 2273 Score = 74.3 bits (181), Expect = 3e-13 Identities = 60/220 (27%), Positives = 106/220 (48%), Gaps = 18/220 (8%) Query: 52 FLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111 F PC +P + NI + + A LG G GK++ L +L P+ SG VL+ G Sbjct: 938 FEPCGRPAVDRL--NIT-FYENQITAFLGHNGAGKTTTLSILTGLLPPT--SGTVLVGGR 992 Query: 112 PRPANFKC---NSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQEL 168 + + G Q +++ LTV E++ F A L+ + E + ++++ Sbjct: 993 DIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLK---GKSQEEAQLEMEAMLEDT 1049 Query: 169 GLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLL 228 GL + + + +SGG +++ S+ + + D ++ LDEPT+G+D + ++ LL Sbjct: 1050 GLHHKRNEEA-----QDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL 1104 Query: 229 KRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG 268 + + GRTII S H + L D + ++A GRL G Sbjct: 1105 LKY-RSGRTIIMSTHHMDEADL-LGDRIAIIAQGRLYCSG 1142 Score = 72.8 bits (177), Expect = 9e-13 Identities = 64/226 (28%), Positives = 96/226 (42%), Gaps = 16/226 (7%) Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFK---CNSGYVVQDDVVMGTL 134 +LG G GK++ +L D + SGD + G N N GY Q D + L Sbjct: 1970 LLGVNGAGKTTTFKMLTG--DTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELL 2027 Query: 135 TVRENLQFSAALRLATTMTNHEKNERI-NRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193 T RE+L A LR E+ E++ N I+ LGL AD GT SGG +++ Sbjct: 2028 TGREHLYLYARLRGVPA----EEIEKVANWSIKSLGLTVYADCLAGTY-----SGGNKRK 2078 Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253 S + LI P ++ LDEPTTG+D + ++ + ++GR ++ + H L Sbjct: 2079 LSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSME-ECEALC 2137 Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIIN 299 L ++ G G Q F +P D L +N Sbjct: 2138 TRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLN 2183 >gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo sapiens] Length = 1642 Score = 73.6 bits (179), Expect = 6e-13 Identities = 53/192 (27%), Positives = 98/192 (51%), Gaps = 13/192 (6%) Query: 56 RKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVL---INGA 111 +K E L N++ I + + A+LG +G GKS+L+++L PS + ++ Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548 Query: 112 PRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171 + G Q D+ LTV ENL A+++ + + + + +V+ +L + Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK---GIPANNIIQEVQKVLLDLDMQ 605 Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231 + D++ + +SGG++++ S+G+ ++ +P IL LDEPT G+D + + V LLK Sbjct: 606 TIKDNQA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK-Y 659 Query: 232 SKQGRTIIFSIH 243 K R +FS H Sbjct: 660 RKANRVTVFSTH 671 Score = 62.0 bits (149), Expect = 2e-09 Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 17/242 (7%) Query: 49 KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSG---LSG 104 K FL RK V+K I+ +K G + +LGP G GKS+++++L +P+ G Sbjct: 1302 KKDFLLSRK-VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLG 1360 Query: 105 DVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164 D + + KC GY Q + + T++E+ + A++ M+ + E I+R+ Sbjct: 1361 DYSSETSEDDDSLKC-MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRI 1416 Query: 165 IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224 L L + V + + G +++ + ++ +P I LDEP+TG+D + Sbjct: 1417 THALDLKEHLQKTV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHM 1471 Query: 225 LLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYH 283 ++ K + R I + H + D + ++ SG+L G Q F GY Sbjct: 1472 WRAIRTAFKNRKRAAILTTHYME-EAEAVCDRVAIMVSGQLRCIGTVQHLKSKF-GKGYF 1529 Query: 284 CE 285 E Sbjct: 1530 LE 1531 >gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo sapiens] Length = 1642 Score = 73.6 bits (179), Expect = 6e-13 Identities = 53/192 (27%), Positives = 98/192 (51%), Gaps = 13/192 (6%) Query: 56 RKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVL---INGA 111 +K E L N++ I + + A+LG +G GKS+L+++L PS + ++ Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548 Query: 112 PRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171 + G Q D+ LTV ENL A+++ + + + + +V+ +L + Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK---GIPANNIIQEVQKVLLDLDMQ 605 Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231 + D++ + +SGG++++ S+G+ ++ +P IL LDEPT G+D + + V LLK Sbjct: 606 TIKDNQA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK-Y 659 Query: 232 SKQGRTIIFSIH 243 K R +FS H Sbjct: 660 RKANRVTVFSTH 671 Score = 62.0 bits (149), Expect = 2e-09 Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 17/242 (7%) Query: 49 KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSG---LSG 104 K FL RK V+K I+ +K G + +LGP G GKS+++++L +P+ G Sbjct: 1302 KKDFLLSRK-VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLG 1360 Query: 105 DVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164 D + + KC GY Q + + T++E+ + A++ M+ + E I+R+ Sbjct: 1361 DYSSETSEDDDSLKC-MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRI 1416 Query: 165 IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224 L L + V + + G +++ + ++ +P I LDEP+TG+D + Sbjct: 1417 THALDLKEHLQKTV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHM 1471 Query: 225 LLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYH 283 ++ K + R I + H + D + ++ SG+L G Q F GY Sbjct: 1472 WRAIRTAFKNRKRAAILTTHYME-EAEAVCDRVAIMVSGQLRCIGTVQHLKSKF-GKGYF 1529 Query: 284 CE 285 E Sbjct: 1530 LE 1531 >gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo sapiens] Length = 738 Score = 70.9 bits (172), Expect = 4e-12 Identities = 64/250 (25%), Positives = 120/250 (48%), Gaps = 13/250 (5%) Query: 31 FTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSL 89 F EG +L+ + ++ K+ E I + + I + A++GP+G GKS++ Sbjct: 477 FNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTV 536 Query: 90 LDVLAARKDPSGLSGDVLINGAP----RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAA 145 L +L DP+ SG + ++G P + G V Q+ ++ + ++ EN+ + A Sbjct: 537 LSLLLRLYDPA--SGTISLDGHDIRQLNPVWLRSKIGTVSQEPILF-SCSIAENIAYGAD 593 Query: 146 LRLATTMTNHEKNERI-NRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDP 204 + T ++ + N V + ++ VG + + +SGG+++R +I L+ +P Sbjct: 594 DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL-LSGGQKQRIAIARALLKNP 652 Query: 205 SILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRL 264 IL LDE T+ LD+ V L R+ GRT++ H R S K + + +L G++ Sbjct: 653 KILLLDEATSALDAENEYLVQEALDRL-MDGRTVLVIAH--RLSTIKNANMVAVLDQGKI 709 Query: 265 MFHGPAQEAL 274 +G +E L Sbjct: 710 TEYGKHEELL 719 >gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sapiens] Length = 1280 Score = 69.7 bits (169), Expect = 8e-12 Identities = 60/206 (29%), Positives = 105/206 (50%), Gaps = 19/206 (9%) Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPANFKCNSGY--VVQDDVVMGT 133 A++G +G GKS+++ +L DP L+G VL++G + N + + +V + ++ Sbjct: 1067 ALVGSSGCGKSTVVQLLERFYDP--LAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFD 1124 Query: 134 LTVRENLQFSAALRLATT--MTNHEKNERINRVIQELG---LDKVADSKVGTQFIRGVSG 188 ++ EN+ + R+ + + K I+ I+ L KV D GTQ +SG Sbjct: 1125 CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDK--GTQ----LSG 1178 Query: 189 GERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYS 248 G+++R +I L+ P IL LDE T+ LD+ + V L + +++GRT I H R S Sbjct: 1179 GQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK-AREGRTCIVIAH--RLS 1235 Query: 249 IFKLFDSLTLLASGRLMFHGPAQEAL 274 + D + + +GR+ HG Q+ L Sbjct: 1236 TIQNADLIVVFQNGRVKEHGTHQQLL 1261 Score = 61.6 bits (148), Expect = 2e-09 Identities = 61/197 (30%), Positives = 103/197 (52%), Gaps = 16/197 (8%) Query: 54 PCRKPVEKEILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP 112 P RK V+ IL +N ++ G A++G +G GKS+ + ++ DP+ G V ++G Sbjct: 402 PSRKEVK--ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPT--EGMVSVDGQD 457 Query: 113 -RPANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN-ERINRVIQE 167 R N + G V Q+ V+ T T+ EN+++ R TM EK + N Sbjct: 458 IRTINVRFLREIIGVVSQEPVLFAT-TIAENIRYG---RENVTMDEIEKAVKEANAYDFI 513 Query: 168 LGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLL 227 + L D+ VG + + +SGG+++R +I L+ +P IL LDE T+ LD+ + V + Sbjct: 514 MKLPHKFDTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572 Query: 228 LKRMSKQGRTIIFSIHQ 244 L + +++GRT I H+ Sbjct: 573 LDK-ARKGRTTIVIAHR 588 >gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C [Homo sapiens] Length = 1232 Score = 68.2 bits (165), Expect = 2e-11 Identities = 59/204 (28%), Positives = 107/204 (52%), Gaps = 15/204 (7%) Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPAN---FKCNSGYVVQDDVVMG 132 A++G +G GKS+++ +L DP L+G VL++G + N + G V Q+ ++ Sbjct: 1019 ALVGSSGCGKSTVVQLLERFYDP--LAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1076 Query: 133 TLTVRENLQFSAALRLATT--MTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGE 190 ++ EN+ + R+ + + + K I+ I+ L +++VG + + +SGG+ Sbjct: 1077 C-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL--PHKYETRVGDKGTQ-LSGGQ 1132 Query: 191 RKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIF 250 ++R +I LI P IL LDE T+ LD+ + V L + +++GRT I H R S Sbjct: 1133 KQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK-AREGRTCIVIAH--RLSTI 1189 Query: 251 KLFDSLTLLASGRLMFHGPAQEAL 274 + D + + +GR+ HG Q+ L Sbjct: 1190 QNADLIVVFQNGRVKEHGTHQQLL 1213 Score = 58.9 bits (141), Expect = 1e-08 Identities = 63/220 (28%), Positives = 107/220 (48%), Gaps = 18/220 (8%) Query: 62 EILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120 +IL +N ++ G A++G +G GKS+ + ++ DP G + I+G NF N Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD--EGTINIDGQDI-RNFNVN 466 Query: 121 S-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN-ERINRVIQELGLDKVA 174 G V Q+ V+ T T+ EN+ + R TM +K + N + L + Sbjct: 467 YLREIIGVVSQEPVLFST-TIAENICYG---RGNVTMDEIKKAVKEANAYEFIMKLPQKF 522 Query: 175 DSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ 234 D+ VG + + +SGG+++R +I L+ +P IL LDE T+ LD+ + V L + +++ Sbjct: 523 DTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDK-ARE 580 Query: 235 GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEAL 274 GRT I H R S + D + G ++ G E + Sbjct: 581 GRTTIVIAH--RLSTVRNADVIAGFEDGVIVEQGSHSELM 618 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.137 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,656,984 Number of Sequences: 37866 Number of extensions: 978979 Number of successful extensions: 2446 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 65 Number of HSP's successfully gapped in prelim test: 11 Number of HSP's that attempted gapping in prelim test: 2153 Number of HSP's gapped (non-prelim): 161 length of query: 655 length of database: 18,247,518 effective HSP length: 109 effective length of query: 546 effective length of database: 14,120,124 effective search space: 7709587704 effective search space used: 7709587704 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.