Guide to the Human Genome
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Search of human proteins with 62526033

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
         (655 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s...  1295   0.0  
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4...   265   1e-70
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s...   263   5e-70
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa...   263   5e-70
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7...   261   1e-69
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6...   261   1e-69
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5...   261   1e-69
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3...   261   1e-69
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2...   261   1e-69
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap...   249   7e-66
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap...   236   4e-62
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s...    92   2e-18
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13...    86   1e-16
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s...    83   9e-16
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo...    81   3e-15
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ...    80   5e-15
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform...    80   6e-15
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform...    80   6e-15
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s...    77   5e-14
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa...    77   7e-14
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ...    76   9e-14
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor...    75   1e-13
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor...    75   1e-13
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...    75   2e-13
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s...    74   3e-13
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ...    74   6e-13
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ...    74   6e-13
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...    71   4e-12
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...    70   8e-12
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...    68   2e-11

>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
           sapiens]
          Length = 655

 Score = 1295 bits (3352), Expect = 0.0
 Identities = 655/655 (100%), Positives = 655/655 (100%)

Query: 1   MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE 60
           MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
Sbjct: 1   MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE 60

Query: 61  KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120
           KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
Sbjct: 61  KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120

Query: 121 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT 180
           SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
Sbjct: 121 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT 180

Query: 181 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF 240
           QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
Sbjct: 181 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF 240

Query: 241 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING 300
           SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
Sbjct: 241 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING 300

Query: 301 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK 360
           DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
Sbjct: 301 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK 360

Query: 361 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS 420
           ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
Sbjct: 361 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS 420

Query: 421 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480
           TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
Sbjct: 421 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480

Query: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL 540
           MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
Sbjct: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL 540

Query: 541 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN 600
           MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
Sbjct: 541 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN 600

Query: 601 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655
           NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
Sbjct: 601 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655


>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
           [Homo sapiens]
          Length = 678

 Score =  265 bits (677), Expect = 1e-70
 Identities = 163/529 (30%), Positives = 294/529 (55%), Gaps = 21/529 (3%)

Query: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 93  RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 151

Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 152 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 209

Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 210 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 264

Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 265 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 324

Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKL-AEIYVNSSFYKETKAELHQL 352
            +++ +G+        +++ +    +     D      L  +  VN   +     E+ Q 
Sbjct: 325 VMEVASGE------YGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQT 378

Query: 353 S--GGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIG 410
               G +K   ++    S++ S   Q   + KR+F +++ +   +  +I   + +GL+IG
Sbjct: 379 KRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIG 438

Query: 411 AIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSY 469
            +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +Y
Sbjct: 439 LLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAY 498

Query: 470 FLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAA 529
           +L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I A
Sbjct: 499 YLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA 557

Query: 530 GQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
             + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 558 ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 606


>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score =  263 bits (671), Expect = 5e-70
 Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%)

Query: 54  PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111
           PC RK   K +L  ++G   +  L  I+GP+G GKS+ +++LA  ++ SG+ G +L+NG 
Sbjct: 74  PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132

Query: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170
           PR    F+  S Y++QDD+++  LTV E +  SA L+L+       K E +  ++  LGL
Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190

Query: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230
              + ++        +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K 
Sbjct: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245

Query: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290
           +++ GRTII +IHQP   +F++FD L +L+ G+ +F G     + Y +  G HC  Y+NP
Sbjct: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305

Query: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350
           ADF +++ +G+   +                     P++ +  +  + +   K++  E +
Sbjct: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345

Query: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408
           ++         ++   +  ++ TS   Q   + KR+F ++L +   +  + +  VV+G++
Sbjct: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405

Query: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467
           IG +Y  + +D++ + N  G LFF      F+++    L F +E  +F+ E+++ +Y + 
Sbjct: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465

Query: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527
           +Y+L K ++D +P +++  +++  IVY+M G   +   F +        A  A S+ L I
Sbjct: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524

Query: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587
            A  + + VAT +  +  + +++FSG  V+  TI ++L W  Y S  RYGF  +    + 
Sbjct: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583

Query: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646
                 G+   G+  C    C   E   + + +D+    L+ + + L    +    +AYL
Sbjct: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636

Query: 647 KLLFLKK 653
            L +  K
Sbjct: 637 VLRYRVK 643


>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score =  263 bits (671), Expect = 5e-70
 Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%)

Query: 54  PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111
           PC RK   K +L  ++G   +  L  I+GP+G GKS+ +++LA  ++ SG+ G +L+NG 
Sbjct: 74  PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132

Query: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170
           PR    F+  S Y++QDD+++  LTV E +  SA L+L+       K E +  ++  LGL
Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190

Query: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230
              + ++        +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K 
Sbjct: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245

Query: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290
           +++ GRTII +IHQP   +F++FD L +L+ G+ +F G     + Y +  G HC  Y+NP
Sbjct: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305

Query: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350
           ADF +++ +G+   +                     P++ +  +  + +   K++  E +
Sbjct: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345

Query: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408
           ++         ++   +  ++ TS   Q   + KR+F ++L +   +  + +  VV+G++
Sbjct: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405

Query: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467
           IG +Y  + +D++ + N  G LFF      F+++    L F +E  +F+ E+++ +Y + 
Sbjct: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465

Query: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527
           +Y+L K ++D +P +++  +++  IVY+M G   +   F +        A  A S+ L I
Sbjct: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524

Query: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587
            A  + + VAT +  +  + +++FSG  V+  TI ++L W  Y S  RYGF  +    + 
Sbjct: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583

Query: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646
                 G+   G+  C    C   E   + + +D+    L+ + + L    +    +AYL
Sbjct: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636

Query: 647 KLLFLKK 653
            L +  K
Sbjct: 637 VLRYRVK 643


>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
           [Homo sapiens]
          Length = 663

 Score =  261 bits (667), Expect = 1e-69
 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)

Query: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 90  RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 148

Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 149 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 206

Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 207 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 261

Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 262 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 321

Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
            +++ +G                   E   Q+  L+  + E   +S   ++    AE++ 
Sbjct: 322 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 362

Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
                  ++ +   E   S++ S   Q   + KR+F +++ +   +  +I   + +GL+I
Sbjct: 363 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 422

Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
           G +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +
Sbjct: 423 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 482

Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
           Y+L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I 
Sbjct: 483 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 541

Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
           A  + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 542 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 591


>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
           [Homo sapiens]
          Length = 644

 Score =  261 bits (667), Expect = 1e-69
 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)

Query: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 71  RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 129

Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 130 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 187

Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 188 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 242

Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 243 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 302

Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
            +++ +G                   E   Q+  L+  + E   +S   ++    AE++ 
Sbjct: 303 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 343

Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
                  ++ +   E   S++ S   Q   + KR+F +++ +   +  +I   + +GL+I
Sbjct: 344 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 403

Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
           G +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +
Sbjct: 404 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 463

Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
           Y+L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I 
Sbjct: 464 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 522

Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
           A  + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 523 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 572


>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
           [Homo sapiens]
          Length = 668

 Score =  261 bits (667), Expect = 1e-69
 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)

Query: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 95  RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 153

Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 154 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 211

Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 212 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 266

Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 267 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 326

Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
            +++ +G                   E   Q+  L+  + E   +S   ++    AE++ 
Sbjct: 327 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 367

Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
                  ++ +   E   S++ S   Q   + KR+F +++ +   +  +I   + +GL+I
Sbjct: 368 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 427

Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
           G +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +
Sbjct: 428 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 487

Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
           Y+L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I 
Sbjct: 488 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 546

Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
           A  + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 547 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 596


>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
           [Homo sapiens]
          Length = 677

 Score =  261 bits (667), Expect = 1e-69
 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)

Query: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 104 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 162

Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 163 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 220

Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 221 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 275

Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 276 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 335

Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
            +++ +G                   E   Q+  L+  + E   +S   ++    AE++ 
Sbjct: 336 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 376

Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
                  ++ +   E   S++ S   Q   + KR+F +++ +   +  +I   + +GL+I
Sbjct: 377 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 436

Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
           G +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +
Sbjct: 437 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 496

Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
           Y+L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I 
Sbjct: 497 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 555

Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
           A  + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 556 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 605


>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
           [Homo sapiens]
          Length = 666

 Score =  261 bits (667), Expect = 1e-69
 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)

Query: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 93  RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 151

Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 152 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 209

Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 210 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 264

Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 265 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 324

Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
            +++ +G                   E   Q+  L+  + E   +S   ++    AE++ 
Sbjct: 325 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 365

Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
                  ++ +   E   S++ S   Q   + KR+F +++ +   +  +I   + +GL+I
Sbjct: 366 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 425

Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
           G +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +
Sbjct: 426 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 485

Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
           Y+L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I 
Sbjct: 486 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 544

Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
           A  + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 545 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 594


>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
           sapiens]
          Length = 651

 Score =  249 bits (635), Expect = 7e-66
 Identities = 179/611 (29%), Positives = 317/611 (51%), Gaps = 47/611 (7%)

Query: 13  SQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMK 72
           SQ +  G PATA    +  + G + + +++ +RV+       CR+   ++IL +++  ++
Sbjct: 21  SQSSLEGAPATAP---EPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVE 77

Query: 73  PG-LNAILGPTGGGKSSLLDVLAARKDPSG-LSGDVLING-APRPANFKCNSGYVVQDDV 129
            G +  ILG +G GK++LLD ++ R   +G   G+V +NG A R   F+    YV+Q D 
Sbjct: 78  SGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDT 137

Query: 130 VMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGG 189
           ++ +LTVRE L ++A L +        + +++  V+ EL L  VAD  +G   + G+S G
Sbjct: 138 LLSSLTVRETLHYTALLAIRRGNPGSFQ-KKVEAVMAELSLSHVADRLIGNYSLGGISTG 196

Query: 190 ERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSI 249
           ER+R SI  +L+ DP ++  DEPTTGLD  TAN +++LL  ++++ R ++ +IHQPR  +
Sbjct: 197 ERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSEL 256

Query: 250 FKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNR 309
           F+LFD + +L+ G L+F G   E L +F   GY C  ++NP DF++D+ + D+     ++
Sbjct: 257 FQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQ----SK 312

Query: 310 EEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISY 369
           E +      IE SK+    ++ +   Y  S+   +T      L   E+ K +     + +
Sbjct: 313 ERE------IETSKR----VQMIESAYKKSAICHKT------LKNIERMKHLKTLPMVPF 356

Query: 370 TT----SFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDST---- 421
            T        +L  + +R  +NL+ N  A I +++  +++GL +  ++F L+  S     
Sbjct: 357 KTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFL--LFFVLRVRSNVLKG 414

Query: 422 GIQNRAGVLF-FLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480
            IQ+R G+L+ F+        ++AV LF V + +   E   G Y+     L   L  +LP
Sbjct: 415 AIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYAL-HVLP 473

Query: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLM---MVAYSASSMALAIAAGQSVVSVA 537
             ++ ++IF+ + Y+ LGL P+   F      L+   ++    + + L I    ++V+  
Sbjct: 474 FSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSV 533

Query: 538 TLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPG--- 594
             L++I  V  ++ SG L N+  +      + YF+  +Y    L  NEF G NF  G   
Sbjct: 534 VALLSIAGV--LVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSN 591

Query: 595 LNATGNNPCNY 605
           ++ T N  C +
Sbjct: 592 VSVTTNPMCAF 602


>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
           sapiens]
          Length = 673

 Score =  236 bits (603), Expect = 4e-62
 Identities = 166/585 (28%), Positives = 289/585 (49%), Gaps = 27/585 (4%)

Query: 77  AILGPTGGGKSSLLDVLAARKDPSGL-SGDVLINGAPRPANF--KCNSGYVVQDDVVMGT 133
           AI+G +G G++SLLDV+  R     + SG + ING P       KC + +V Q + ++  
Sbjct: 102 AIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVA-HVRQHNQLLPN 160

Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
           LTVRE L F A +RL  T +  ++++R+  VI EL L + AD++VG  ++RG+SGGER+R
Sbjct: 161 LTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRR 220

Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
            SIG++L+ +P IL LDEPT+GLDS TA+ ++  L R++K  R ++ S+HQPR  IF+LF
Sbjct: 221 VSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLF 280

Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDF 313
           D + L+ SG  ++ G AQ  + YF + GY C  Y+NPADF++D+ + D      +RE++ 
Sbjct: 281 DLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR----SREQEL 336

Query: 314 KATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQ---LSGGEKKKKITVFKEISYT 370
              E  +        +EK+ ++  +   +K    +L +   +               +  
Sbjct: 337 ATRE--KAQSLAALFLEKVRDL--DDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKM 392

Query: 371 TSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVL 430
                Q   + +R   N   +    +       ++ + IG +YFG  +      + A +L
Sbjct: 393 PGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALL 452

Query: 431 FFLTTNQCFSSV-SAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIF 489
           F +     F+ +   +     E+ +  +E   G Y    YF  K+L + LP      II+
Sbjct: 453 FMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGE-LPEHCAYIIIY 511

Query: 490 TCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMM 549
               Y++  L+P    F +    + +V +    MALA AA      +A+      +    
Sbjct: 512 GMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFY 571

Query: 550 IFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNF-CPGLNATGNNPCNYATC 608
           +  G ++NL+++ +  +W+   S  R+ F  L   +F  + +  P  N T          
Sbjct: 572 LAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLT-------IAV 624

Query: 609 TGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKK 653
           +G++ L    +D  P  L+  ++ +  +   F+ + Y+ L F+K+
Sbjct: 625 SGDKILSVMELDSYP--LYAIYLIVIGLSGGFMVLYYVSLRFIKQ 667


>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
           sapiens]
          Length = 1624

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 57/170 (33%), Positives = 95/170 (55%), Gaps = 12/170 (7%)

Query: 75  LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA---NFKCNSGYVVQDDVVM 131
           + A+LG +G GK++LL++L+    P+  S  V  +   R A   N    +G+  Q +V  
Sbjct: 512 ITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQF 571

Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
           G LTV+ENL+  A ++    +  HE  + + RV+QEL ++ + D        + +SGG+ 
Sbjct: 572 GFLTVKENLRLFAKIK---GILPHEVEKEVQRVVQELEMENIQDI-----LAQNLSGGQN 623

Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241
           ++ + G+ ++ DP +L LDEPT GLD  + + +  LLK   K  R I+FS
Sbjct: 624 RKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSDRVILFS 672



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 57/238 (23%), Positives = 110/238 (46%), Gaps = 21/238 (8%)

Query: 44   YRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGL 102
            Y  K K+ F   +K +      N++  +K G +  +LG  G GKS+ + ++     P+  
Sbjct: 1292 YAGKKKNCFSKRKKKIATR---NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPT-- 1346

Query: 103  SGDVLINGAP--RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER 160
            +G V++ G+    P  F    GY  Q++ +   LTVR++L+  AA++    +   +    
Sbjct: 1347 AGQVILKGSGGGEPLGFL---GYCPQENALWPNLTVRQHLEVYAAVK---GLRKGDAMIA 1400

Query: 161  INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSST 220
            I R++  L L     + V T     +S G +++    + ++ +PS++ LDEP+TG+D   
Sbjct: 1401 ITRLVDALKLQDQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEG 1455

Query: 221  ANAVLLLLKRMSKQ-GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
               +  +++   +   R  + + H        + D + ++ SGRL   G  Q     F
Sbjct: 1456 QQQMWQVIRATFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1512


>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
            [Homo sapiens]
          Length = 5058

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 58/198 (29%), Positives = 108/198 (54%), Gaps = 13/198 (6%)

Query: 75   LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131
            + A+LG  G GK++++ +L     P+  SG ++ING     +    +   G   Q D+++
Sbjct: 3870 ITALLGTNGAGKTTIISMLTGLHPPT--SGTIIINGKNLQTDLSRVRMELGVCPQQDILL 3927

Query: 132  GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
              LTVRE+L   A+++ A   T  E ++++N+ +Q++ L +    +      R +SGG +
Sbjct: 3928 DNLTVREHLLLFASIK-APQWTKKELHQQVNQTLQDVDLTQHQHKQT-----RALSGGLK 3981

Query: 192  KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
            ++ S+G+  +     + LDEPT+G+D  + +++  +L +  ++GRTIIF+ H        
Sbjct: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKY-REGRTIIFTTHH-LDEAEA 4039

Query: 252  LFDSLTLLASGRLMFHGP 269
            L D + +L  GRL   GP
Sbjct: 4040 LSDRVAVLQHGRLRCCGP 4057



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 17/182 (9%)

Query: 69   GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSG------ 122
            GI K     +LG  G GKS+   +L    + S  SG  +I      A    ++G      
Sbjct: 4743 GIPKGECFGLLGVNGAGKSTTFKMLNG--EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI 4800

Query: 123  -YVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQ 181
             Y  Q D +   LT  E+L +  +LR    +      E    +I+ L L+  AD  V T 
Sbjct: 4801 GYCPQQDALDELLTGWEHLYYYCSLR---GIPRQCIPEVAGDLIRRLHLEAHADKPVATY 4857

Query: 182  FIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241
                 SGG +++ S  + L+  P IL LDEP++G+D  +   +   + +  ++G   + +
Sbjct: 4858 -----SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912

Query: 242  IH 243
             H
Sbjct: 4913 SH 4914


>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
           sapiens]
          Length = 1704

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 69/225 (30%), Positives = 113/225 (50%), Gaps = 20/225 (8%)

Query: 75  LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVM 131
           +  +LG  G GK++ L +L     P+  SG   I+G   +      + + G   Q D++ 
Sbjct: 561 ITVLLGHNGAGKTTTLSMLTGLFPPT--SGRAYISGYEISQDMVQIRKSLGLCPQHDILF 618

Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
             LTV E+L F A L+    ++  +  E + +++  +GL+   +S+      R +SGG R
Sbjct: 619 DNLTVAEHLYFYAQLK---GLSRQKCPEEVKQMLHIIGLEDKWNSRS-----RFLSGGMR 670

Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
           ++ SIG+ LI    +L LDEPT+G+D+ +  A+  LL+R  K  RTI+ + H    +   
Sbjct: 671 RKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADL- 728

Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHC----EAYNNPAD 292
           L D + ++A G L   G +   L     AGYH     E + NP D
Sbjct: 729 LGDRIAIMAKGELQCCG-SSLFLKQKYGAGYHMTLVKEPHCNPED 772



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 57/212 (26%), Positives = 94/212 (44%), Gaps = 15/212 (7%)

Query: 78   ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
            +LG  G GK++   +L   +  S  SGD  + G   +      +   GY  Q D ++  +
Sbjct: 1414 LLGFNGAGKTTTFKMLTGEE--SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHM 1471

Query: 135  TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
            T RE L   A LR    +        +   ++ L L+  A+     + +R  SGG +++ 
Sbjct: 1472 TGREMLVMYARLR---GIPERHIGACVENTLRGLLLEPHAN-----KLVRTYSGGNKRKL 1523

Query: 195  SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
            S G+ LI +P+++FLDEP+TG+D      +   + R  + G+ II + H        L  
Sbjct: 1524 STGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSME-ECEALCT 1582

Query: 255  SLTLLASGRLMFHGPAQEALGYFESAGYHCEA 286
             L ++  G+    G  Q     F S GY   A
Sbjct: 1583 RLAIMVQGQFKCLGSPQHLKSKFGS-GYSLRA 1613


>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
           sapiens]
          Length = 1543

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 14/218 (6%)

Query: 75  LNAILGPTGGGKSSLLDVLAARK---DPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVM 131
           + AILG  G GKS+LL++L+      + S    +  ++        + N G+  Q +   
Sbjct: 422 ITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQF 481

Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
             LTVRENL+  A ++    +   E  + + R+I EL +  + D        + +SGG++
Sbjct: 482 DFLTVRENLRVFAKIK---GIQPKEVEQEVKRIIMELDMQSIQDI-----IAKKLSGGQK 533

Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
           ++ ++G+ ++ DP +L LDEPT GLD  + + V  LLK   K  R I+FS  Q       
Sbjct: 534 RKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRLILFST-QFMDEADI 591

Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289
           L D    L++G+L   G +   L      GYH   + N
Sbjct: 592 LADRKVFLSNGKLKCAG-SSLFLKRKWGIGYHLSLHRN 628



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 57/245 (23%), Positives = 115/245 (46%), Gaps = 22/245 (8%)

Query: 40   HNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKD 98
            H   Y  K KS F   +K +    + N++  +K G +  +LG  G GKS+ + ++     
Sbjct: 1202 HKEYYETK-KSCFSTRKKKIA---IRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTK 1257

Query: 99   PSGLSGDVLINGAPRPANFKCNS-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMT 153
            P+  +G V++ G+      + ++     GY  Q++ +   LT++E+L+  AA++    + 
Sbjct: 1258 PT--AGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVK---GLG 1312

Query: 154  NHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPT 213
              +    I+R+++ L L +   + V T     +S G +++    + ++ +PS++ LDEP 
Sbjct: 1313 KEDAALSISRLVEALKLQEQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPF 1367

Query: 214  TGLDSSTANAVLLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQE 272
            TG+D      +  +L+   K + R  + + H        + D + ++ SG L   G  Q 
Sbjct: 1368 TGMDPEGQQQMWQILQATVKNKERGTLLTTHY-MSEAEAVCDRMAMMVSGTLRCIGSIQH 1426

Query: 273  ALGYF 277
                F
Sbjct: 1427 LKNKF 1431


>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
            sapiens]
          Length = 2146

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 60/208 (28%), Positives = 99/208 (47%), Gaps = 15/208 (7%)

Query: 78   ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
            +LG  G GK+S   ++    D     G+ ++ G   A  P+    + GY  Q D +   L
Sbjct: 1825 LLGVNGAGKTSTFRMVTG--DTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882

Query: 135  TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
            T RE+L+  A LR    +   +  +     +  LGL   AD   GT      SGG +++ 
Sbjct: 1883 TGREHLELLARLR---GVPEAQVAQTAGSGLARLGLSWYADRPAGTY-----SGGNKRKL 1934

Query: 195  SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
            +  + L+ DP+++FLDEPTTG+D S    +   L  + ++GR+++ + H        L  
Sbjct: 1935 ATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSME-ECEALCS 1993

Query: 255  SLTLLASGRLMFHGPAQEALGYFESAGY 282
             L ++ +GR    G  Q   G F +AG+
Sbjct: 1994 RLAIMVNGRFRCLGSPQHLKGRF-AAGH 2020



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 58/192 (30%), Positives = 102/192 (53%), Gaps = 13/192 (6%)

Query: 75   LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP-ANFKCNSGYVVQDDVVMGT 133
            + A LG  G GK++ L +L+    PSG S  +L +      A  + + G   Q +V+   
Sbjct: 836  ITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDM 895

Query: 134  LTVRENLQFSAALR-LATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERK 192
            LTV E++ F   L+ L+  +   E++    R++Q++GL  V+   V T   R +SGG ++
Sbjct: 896  LTVDEHVWFYGRLKGLSAAVVGPEQD----RLLQDVGL--VSKQSVQT---RHLSGGMQR 946

Query: 193  RTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKL 252
            + S+ +  +    ++ LDEPT G+D ++   +  LL +  ++GRT+I S H    +   L
Sbjct: 947  KLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKY-REGRTLILSTHHLDEAEL-L 1004

Query: 253  FDSLTLLASGRL 264
             D + ++A GRL
Sbjct: 1005 GDRVAVVAGGRL 1016


>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
            [Homo sapiens]
          Length = 2436

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%)

Query: 78   ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
            +LG  G GK+S   +L    D S   G+  +NG          + + GY  Q D +   L
Sbjct: 2086 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2143

Query: 135  TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
            T RE+LQ    LR    ++  ++   +   +++L L K AD   GT      SGG +++ 
Sbjct: 2144 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2195

Query: 195  SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
            S  + LI  P+ +FLDEPTTG+D      +  L+  + K GR+++ + H        L  
Sbjct: 2196 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2254

Query: 255  SLTLLASGRLMFHGPAQEALGYF 277
             L ++ +GRL   G  Q     F
Sbjct: 2255 RLAIMVNGRLRCLGSIQHLKNRF 2277



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%)

Query: 77   AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133
            + LG  G GK++ + +L     P+  SG   I G          + N G   Q +V+   
Sbjct: 1022 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1079

Query: 134  LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
            LTV E+L F + L+   +M   E    ++++I++L L     S V T     +SGG +++
Sbjct: 1080 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1131

Query: 194  TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
             S+ +  +     + LDEPT G+D     A+  L+ +  K GRTI+ S H    +   L 
Sbjct: 1132 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1189

Query: 254  DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292
            D + +++ G+L   G      G +   GY       PA+
Sbjct: 1190 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1227


>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
            [Homo sapiens]
          Length = 2466

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%)

Query: 78   ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
            +LG  G GK+S   +L    D S   G+  +NG          + + GY  Q D +   L
Sbjct: 2116 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2173

Query: 135  TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
            T RE+LQ    LR    ++  ++   +   +++L L K AD   GT      SGG +++ 
Sbjct: 2174 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2225

Query: 195  SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
            S  + LI  P+ +FLDEPTTG+D      +  L+  + K GR+++ + H        L  
Sbjct: 2226 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2284

Query: 255  SLTLLASGRLMFHGPAQEALGYF 277
             L ++ +GRL   G  Q     F
Sbjct: 2285 RLAIMVNGRLRCLGSIQHLKNRF 2307



 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%)

Query: 77   AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133
            + LG  G GK++ + +L     P+  SG   I G          + N G   Q +V+   
Sbjct: 1052 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1109

Query: 134  LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
            LTV E+L F + L+   +M   E    ++++I++L L     S V T     +SGG +++
Sbjct: 1110 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1161

Query: 194  TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
             S+ +  +     + LDEPT G+D     A+  L+ +  K GRTI+ S H    +   L 
Sbjct: 1162 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1219

Query: 254  DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292
            D + +++ G+L   G      G +   GY       PA+
Sbjct: 1220 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1257


>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
           sapiens]
          Length = 1617

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 64/218 (29%), Positives = 105/218 (48%), Gaps = 14/218 (6%)

Query: 75  LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131
           + AILG +G GKSSLL++L     P+  S  +         +    +  +G   Q +V  
Sbjct: 509 ITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQF 568

Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
             LTV+ENL   A ++    +   E  + + R++ EL +  + D+       + +S G++
Sbjct: 569 DILTVKENLSLFAKIK---GIHLKEVEQEVQRILLELDMQNIQDN-----LAKHLSEGQK 620

Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
           ++ + G+ ++ DP IL LDEPTTGLD  + + V  LL R  +    I+FS  Q       
Sbjct: 621 RKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL-RERRADHVILFST-QSMDEADI 678

Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289
           L D   ++++GRL   G +   L      GYH   + N
Sbjct: 679 LADRKVIMSNGRLKCAGSSM-FLKRRWGLGYHLSLHRN 715



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 53/217 (24%), Positives = 106/217 (48%), Gaps = 16/217 (7%)

Query: 57   KPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA 115
            K  +K    NI+  ++ G +  +LGP G GKSS + +++    P+  +G+V + G    +
Sbjct: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPT--AGEVELKGC---S 1350

Query: 116  NFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVAD 175
            +   + GY  Q++V+   LT+RE+L+  AA++    +   +    I R++    L +  +
Sbjct: 1351 SVLGHLGYCPQENVLWPMLTLREHLEVYAAVK---GLRKADARLAIARLVSAFKLHEQLN 1407

Query: 176  SKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ- 234
              V     + ++ G  ++    + L+ +  +L LDEP+TG+D +    +   ++ + K  
Sbjct: 1408 VPV-----QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNT 1462

Query: 235  GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271
             R ++ + H        L D + ++ SGRL   G  Q
Sbjct: 1463 ERGVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGSIQ 1498


>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
            sapiens]
          Length = 2261

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 14/203 (6%)

Query: 78   ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFK---CNSGYVVQDDVVMGTL 134
            +LG  G GKSS   +L    D +   GD  +N     +N      N GY  Q D +   L
Sbjct: 1944 LLGVNGAGKSSTFKMLTG--DTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELL 2001

Query: 135  TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
            T RE+++F A LR    +   E  +     I++LGL      K G ++    SGG +++ 
Sbjct: 2002 TGREHVEFFALLR---GVPEKEVGKVGEWAIRKLGL-----VKYGEKYAGNYSGGNKRKL 2053

Query: 195  SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
            S  M LI  P ++FLDEPTTG+D      +      + K+GR+++ + H        L  
Sbjct: 2054 STAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSME-ECEALCT 2112

Query: 255  SLTLLASGRLMFHGPAQEALGYF 277
             + ++ +GR    G  Q     F
Sbjct: 2113 RMAIMVNGRFRCLGSVQHLKNRF 2135



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 64/244 (26%), Positives = 109/244 (44%), Gaps = 21/244 (8%)

Query: 75   LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP---RPANFKCNSGYVVQDDVVM 131
            + + LG  G GK++ + +L     P+  SG   I G       +  + N G   Q +V+ 
Sbjct: 928  ITSFLGHNGAGKTTTMSILTGLFPPT--SGTAYILGKDIRSEMSTIRQNLGVCPQHNVLF 985

Query: 132  GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
              LTV E++ F A  RL      H K E     ++++ LD    S         +SGG +
Sbjct: 986  DMLTVEEHIWFYA--RLKGLSEKHVKAE-----MEQMALDVGLPSSKLKSKTSQLSGGMQ 1038

Query: 192  KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
            ++ S+ +  +    ++ LDEPT G+D  +   +  LL +  +QGRTII S H    +   
Sbjct: 1039 RKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY-RQGRTIILSTHHMDEADV- 1096

Query: 252  LFDSLTLLASGRLMFHGPA---QEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALN 308
            L D + +++ G+L   G +   +  LG     GY+        +  L      S+ V+  
Sbjct: 1097 LGDRIAIISHGKLCCVGSSLFLKNQLG----TGYYLTLVKKDVESSLSSCRNSSSTVSYL 1152

Query: 309  REED 312
            ++ED
Sbjct: 1153 KKED 1156


>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
           sapiens]
          Length = 718

 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 66/246 (26%), Positives = 119/246 (48%), Gaps = 28/246 (11%)

Query: 37  LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95
           ++F N+C+    + GF         E+L +    + PG + A++G +GGGK+++  +L  
Sbjct: 455 VTFQNVCFSYPCRPGF---------EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLER 505

Query: 96  RKDPSGLSGDVLINGAPR----PANFKCNS-GYVVQDDVVMGTLTVRENLQFSAALRLAT 150
             DP+  +G V+++G       P+  +    G++ Q+ V+ GT T+ EN++F        
Sbjct: 506 FYDPT--AGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT-TIMENIRFGKLEASDE 562

Query: 151 TMTNHEKNERINRVIQEL--GLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILF 208
            +    +    +  I     G + V   +  T     +SGG+++R +I   LI  P++L 
Sbjct: 563 EVYTAAREANAHEFITSFPEGYNTVVGERGTT-----LSGGQKQRLAIARALIKQPTVLI 617

Query: 209 LDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG 268
           LDE T+ LD+ +   V   L R S  GRT++   H  R S  +    + ++A GR+   G
Sbjct: 618 LDEATSALDAESERVVQEALDRAS-AGRTVLVIAH--RLSTVRGAHCIVVMADGRVWEAG 674

Query: 269 PAQEAL 274
             +E L
Sbjct: 675 THEELL 680


>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
            [Homo sapiens]
          Length = 2277

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 21/230 (9%)

Query: 61   KEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF-- 117
            K  + N+N     G + ++LGP G GK++ + +L      S  +G + + G     +   
Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS--AGTIFVYGKDIKTDLHT 1097

Query: 118  -KCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADS 176
             + N G  +Q DV+   LT +E+L    ++++    T  + +E + R +++ GL      
Sbjct: 1098 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRHK 1156

Query: 177  KVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR 236
            +VGT     +SGG +++ SI + LI    ++ LDEP+TG+D  +  ++  ++ + +K  R
Sbjct: 1157 RVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTAR 1210

Query: 237  TIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGP---AQEALGYFESAGYH 283
            TII S H    +   L D +  L  G L   G     +EA G     GYH
Sbjct: 1211 TIILSTHHLDEAEV-LSDRIAFLEQGGLRCCGSPFYLKEAFG----DGYH 1255



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 18/226 (7%)

Query: 59   VEKEILSNIN---GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLI-NGAPRP 114
            + K+I++  N   GI       +LG  G GK+++  +L     PS  SG++LI N     
Sbjct: 1948 IHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS--SGNILIRNKTGSL 2005

Query: 115  ANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
             +   +S   GY  Q+D +   +TV E+L F A +     +   +  E ++++++ L L 
Sbjct: 2006 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLM 2062

Query: 172  KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
               D           S G +++ S  + LI  PSIL LDEP++G+D  +   +  ++   
Sbjct: 2063 PFKDRATSM-----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEE 2117

Query: 232  SKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
             +   ++I + H        L   L ++ +G+    G  Q     F
Sbjct: 2118 VQNKCSVILTSHSME-ECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2162


>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
            [Homo sapiens]
          Length = 2595

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 21/230 (9%)

Query: 61   KEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF-- 117
            K  + N+N     G + ++LGP G GK++ + +L      S  +G + + G     +   
Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS--AGTIFVYGKDIKTDLHT 1415

Query: 118  -KCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADS 176
             + N G  +Q DV+   LT +E+L    ++++    T  + +E + R +++ GL      
Sbjct: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRHK 1474

Query: 177  KVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR 236
            +VGT     +SGG +++ SI + LI    ++ LDEP+TG+D  +  ++  ++ + +K  R
Sbjct: 1475 RVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTAR 1528

Query: 237  TIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGP---AQEALGYFESAGYH 283
            TII S H    +   L D +  L  G L   G     +EA G     GYH
Sbjct: 1529 TIILSTHHLDEAEV-LSDRIAFLEQGGLRCCGSPFYLKEAFG----DGYH 1573



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 18/226 (7%)

Query: 59   VEKEILSNIN---GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLI-NGAPRP 114
            + K+I++  N   GI       +LG  G GK+++  +L     PS  SG++LI N     
Sbjct: 2266 IHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS--SGNILIRNKTGSL 2323

Query: 115  ANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
             +   +S   GY  Q+D +   +TV E+L F A +     +   +  E ++++++ L L 
Sbjct: 2324 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLM 2380

Query: 172  KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
               D           S G +++ S  + LI  PSIL LDEP++G+D  +   +  ++   
Sbjct: 2381 PFKDRATSM-----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEE 2435

Query: 232  SKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
             +   ++I + H        L   L ++ +G+    G  Q     F
Sbjct: 2436 VQNKCSVILTSHSME-ECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
           [Homo sapiens]
          Length = 1321

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 87/322 (27%), Positives = 141/322 (43%), Gaps = 47/322 (14%)

Query: 37  LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95
           + FHN+ +         P R  V+  IL+++N ++KPG + A++GP+G GKS+ L ++  
Sbjct: 420 IEFHNVTFHY-------PSRPEVK--ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQR 470

Query: 96  RKDPSGLSGDVLINGAP-RPANFKC---NSGYVVQDDVVMGTLTVRENLQFSAALRLATT 151
             DP    G V ++G   R  N +      G V Q+ V+  T T+ EN+++         
Sbjct: 471 FYDPC--EGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFST-TIAENIRYGREDATMED 527

Query: 152 MTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDE 211
           +    K       I +L   +  D+ VG    + +SGG+++R +I   LI +P IL LD 
Sbjct: 528 IVQAAKEANAYNFIMDL--PQQFDTLVGEGGGQ-MSGGQKQRVAIARALIRNPKILLLDM 584

Query: 212 PTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271
            T+ LD+ +   V  +L ++ + G TII   H  R S  +  D++          HG A 
Sbjct: 585 ATSALDNESEAMVQEVLSKI-QHGHTIISVAH--RLSTVRAADTIIGFE------HGTAV 635

Query: 272 EALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEK 331
           E        G H E       +F  +        ALN E+   ATE            + 
Sbjct: 636 E-------RGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATE-----------DDM 677

Query: 332 LAEIYVNSSFYKETKAELHQLS 353
           LA  +   S+    +A + Q S
Sbjct: 678 LARTFSRGSYQDSLRASIRQRS 699



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 60/230 (26%), Positives = 115/230 (50%), Gaps = 32/230 (13%)

Query: 60   EKEILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPAN- 116
            + ++L+ ++  + PG   A +G +G GKS+ + +L    DP    G V+I+G   +  N 
Sbjct: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPD--QGKVMIDGHDSKKVNV 1149

Query: 117  --FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQE------- 167
               + N G V Q+ V+    ++ +N+++           ++ K   + RVI         
Sbjct: 1150 QFLRSNIGIVSQEPVLFAC-SIMDNIKYG----------DNTKEIPMERVIAAAKQAQLH 1198

Query: 168  ---LGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224
               + L +  ++ VG+Q  + +S GE++R +I   ++ DP IL LDE T+ LD+ +   V
Sbjct: 1199 DFVMSLPEKYETNVGSQGSQ-LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV 1257

Query: 225  LLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEAL 274
             + L + +++GRT I   H  R S  +  D + ++A G ++  G  +E +
Sbjct: 1258 QVALDK-AREGRTCIVIAH--RLSTIQNADIIAVMAQGVVIEKGTHEELM 1304


>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
            sapiens]
          Length = 2273

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 60/220 (27%), Positives = 106/220 (48%), Gaps = 18/220 (8%)

Query: 52   FLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111
            F PC +P    +  NI    +  + A LG  G GK++ L +L     P+  SG VL+ G 
Sbjct: 938  FEPCGRPAVDRL--NIT-FYENQITAFLGHNGAGKTTTLSILTGLLPPT--SGTVLVGGR 992

Query: 112  PRPANFKC---NSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQEL 168
                +      + G   Q +++   LTV E++ F A L+     +  E    +  ++++ 
Sbjct: 993  DIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLK---GKSQEEAQLEMEAMLEDT 1049

Query: 169  GLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLL 228
            GL    + +      + +SGG +++ S+ +  + D  ++ LDEPT+G+D  +  ++  LL
Sbjct: 1050 GLHHKRNEEA-----QDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL 1104

Query: 229  KRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG 268
             +  + GRTII S H    +   L D + ++A GRL   G
Sbjct: 1105 LKY-RSGRTIIMSTHHMDEADL-LGDRIAIIAQGRLYCSG 1142



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 64/226 (28%), Positives = 96/226 (42%), Gaps = 16/226 (7%)

Query: 78   ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFK---CNSGYVVQDDVVMGTL 134
            +LG  G GK++   +L    D +  SGD  + G     N      N GY  Q D +   L
Sbjct: 1970 LLGVNGAGKTTTFKMLTG--DTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELL 2027

Query: 135  TVRENLQFSAALRLATTMTNHEKNERI-NRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
            T RE+L   A LR        E+ E++ N  I+ LGL   AD   GT      SGG +++
Sbjct: 2028 TGREHLYLYARLRGVPA----EEIEKVANWSIKSLGLTVYADCLAGTY-----SGGNKRK 2078

Query: 194  TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
             S  + LI  P ++ LDEPTTG+D      +  ++  + ++GR ++ + H        L 
Sbjct: 2079 LSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSME-ECEALC 2137

Query: 254  DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIIN 299
              L ++  G     G  Q     F           +P D  L  +N
Sbjct: 2138 TRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLN 2183


>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 53/192 (27%), Positives = 98/192 (51%), Gaps = 13/192 (6%)

Query: 56  RKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVL---INGA 111
           +K    E L N++  I +  + A+LG +G GKS+L+++L     PS     +    ++  
Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548

Query: 112 PRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
                 +   G   Q D+    LTV ENL   A+++    +  +   + + +V+ +L + 
Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK---GIPANNIIQEVQKVLLDLDMQ 605

Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
            + D++      + +SGG++++ S+G+ ++ +P IL LDEPT G+D  + + V  LLK  
Sbjct: 606 TIKDNQA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK-Y 659

Query: 232 SKQGRTIIFSIH 243
            K  R  +FS H
Sbjct: 660 RKANRVTVFSTH 671



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 17/242 (7%)

Query: 49   KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSG---LSG 104
            K  FL  RK V+K     I+  +K G +  +LGP G GKS+++++L    +P+      G
Sbjct: 1302 KKDFLLSRK-VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLG 1360

Query: 105  DVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164
            D     +    + KC  GY  Q + +    T++E+ +   A++    M+  +  E I+R+
Sbjct: 1361 DYSSETSEDDDSLKC-MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRI 1416

Query: 165  IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224
               L L +     V     + +  G +++    + ++ +P I  LDEP+TG+D      +
Sbjct: 1417 THALDLKEHLQKTV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHM 1471

Query: 225  LLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYH 283
               ++   K + R  I + H        + D + ++ SG+L   G  Q     F   GY 
Sbjct: 1472 WRAIRTAFKNRKRAAILTTHYME-EAEAVCDRVAIMVSGQLRCIGTVQHLKSKF-GKGYF 1529

Query: 284  CE 285
             E
Sbjct: 1530 LE 1531


>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 53/192 (27%), Positives = 98/192 (51%), Gaps = 13/192 (6%)

Query: 56  RKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVL---INGA 111
           +K    E L N++  I +  + A+LG +G GKS+L+++L     PS     +    ++  
Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548

Query: 112 PRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
                 +   G   Q D+    LTV ENL   A+++    +  +   + + +V+ +L + 
Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK---GIPANNIIQEVQKVLLDLDMQ 605

Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
            + D++      + +SGG++++ S+G+ ++ +P IL LDEPT G+D  + + V  LLK  
Sbjct: 606 TIKDNQA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK-Y 659

Query: 232 SKQGRTIIFSIH 243
            K  R  +FS H
Sbjct: 660 RKANRVTVFSTH 671



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 17/242 (7%)

Query: 49   KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSG---LSG 104
            K  FL  RK V+K     I+  +K G +  +LGP G GKS+++++L    +P+      G
Sbjct: 1302 KKDFLLSRK-VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLG 1360

Query: 105  DVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164
            D     +    + KC  GY  Q + +    T++E+ +   A++    M+  +  E I+R+
Sbjct: 1361 DYSSETSEDDDSLKC-MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRI 1416

Query: 165  IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224
               L L +     V     + +  G +++    + ++ +P I  LDEP+TG+D      +
Sbjct: 1417 THALDLKEHLQKTV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHM 1471

Query: 225  LLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYH 283
               ++   K + R  I + H        + D + ++ SG+L   G  Q     F   GY 
Sbjct: 1472 WRAIRTAFKNRKRAAILTTHYME-EAEAVCDRVAIMVSGQLRCIGTVQHLKSKF-GKGYF 1529

Query: 284  CE 285
             E
Sbjct: 1530 LE 1531


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 64/250 (25%), Positives = 120/250 (48%), Gaps = 13/250 (5%)

Query: 31  FTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSL 89
           F EG +L+  +    ++ K+         E  I  + +  I    + A++GP+G GKS++
Sbjct: 477 FNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTV 536

Query: 90  LDVLAARKDPSGLSGDVLINGAP----RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAA 145
           L +L    DP+  SG + ++G       P   +   G V Q+ ++  + ++ EN+ + A 
Sbjct: 537 LSLLLRLYDPA--SGTISLDGHDIRQLNPVWLRSKIGTVSQEPILF-SCSIAENIAYGAD 593

Query: 146 LRLATTMTNHEKNERI-NRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDP 204
              + T    ++   + N V       +  ++ VG + +  +SGG+++R +I   L+ +P
Sbjct: 594 DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL-LSGGQKQRIAIARALLKNP 652

Query: 205 SILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRL 264
            IL LDE T+ LD+     V   L R+   GRT++   H  R S  K  + + +L  G++
Sbjct: 653 KILLLDEATSALDAENEYLVQEALDRL-MDGRTVLVIAH--RLSTIKNANMVAVLDQGKI 709

Query: 265 MFHGPAQEAL 274
             +G  +E L
Sbjct: 710 TEYGKHEELL 719


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
            sapiens]
          Length = 1280

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 60/206 (29%), Positives = 105/206 (50%), Gaps = 19/206 (9%)

Query: 77   AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPANFKCNSGY--VVQDDVVMGT 133
            A++G +G GKS+++ +L    DP  L+G VL++G   +  N +    +  +V  + ++  
Sbjct: 1067 ALVGSSGCGKSTVVQLLERFYDP--LAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFD 1124

Query: 134  LTVRENLQFSAALRLATT--MTNHEKNERINRVIQELG---LDKVADSKVGTQFIRGVSG 188
             ++ EN+ +    R+ +   +    K   I+  I+ L      KV D   GTQ    +SG
Sbjct: 1125 CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDK--GTQ----LSG 1178

Query: 189  GERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYS 248
            G+++R +I   L+  P IL LDE T+ LD+ +   V   L + +++GRT I   H  R S
Sbjct: 1179 GQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK-AREGRTCIVIAH--RLS 1235

Query: 249  IFKLFDSLTLLASGRLMFHGPAQEAL 274
              +  D + +  +GR+  HG  Q+ L
Sbjct: 1236 TIQNADLIVVFQNGRVKEHGTHQQLL 1261



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 61/197 (30%), Positives = 103/197 (52%), Gaps = 16/197 (8%)

Query: 54  PCRKPVEKEILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP 112
           P RK V+  IL  +N  ++ G   A++G +G GKS+ + ++    DP+   G V ++G  
Sbjct: 402 PSRKEVK--ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPT--EGMVSVDGQD 457

Query: 113 -RPANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN-ERINRVIQE 167
            R  N +      G V Q+ V+  T T+ EN+++    R   TM   EK  +  N     
Sbjct: 458 IRTINVRFLREIIGVVSQEPVLFAT-TIAENIRYG---RENVTMDEIEKAVKEANAYDFI 513

Query: 168 LGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLL 227
           + L    D+ VG +  + +SGG+++R +I   L+ +P IL LDE T+ LD+ +   V + 
Sbjct: 514 MKLPHKFDTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572

Query: 228 LKRMSKQGRTIIFSIHQ 244
           L + +++GRT I   H+
Sbjct: 573 LDK-ARKGRTTIVIAHR 588


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
            [Homo sapiens]
          Length = 1232

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 59/204 (28%), Positives = 107/204 (52%), Gaps = 15/204 (7%)

Query: 77   AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPAN---FKCNSGYVVQDDVVMG 132
            A++G +G GKS+++ +L    DP  L+G VL++G   +  N    +   G V Q+ ++  
Sbjct: 1019 ALVGSSGCGKSTVVQLLERFYDP--LAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1076

Query: 133  TLTVRENLQFSAALRLATT--MTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGE 190
              ++ EN+ +    R+ +   + +  K   I+  I+ L      +++VG +  + +SGG+
Sbjct: 1077 C-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL--PHKYETRVGDKGTQ-LSGGQ 1132

Query: 191  RKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIF 250
            ++R +I   LI  P IL LDE T+ LD+ +   V   L + +++GRT I   H  R S  
Sbjct: 1133 KQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK-AREGRTCIVIAH--RLSTI 1189

Query: 251  KLFDSLTLLASGRLMFHGPAQEAL 274
            +  D + +  +GR+  HG  Q+ L
Sbjct: 1190 QNADLIVVFQNGRVKEHGTHQQLL 1213



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 63/220 (28%), Positives = 107/220 (48%), Gaps = 18/220 (8%)

Query: 62  EILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120
           +IL  +N  ++ G   A++G +G GKS+ + ++    DP    G + I+G     NF  N
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD--EGTINIDGQDI-RNFNVN 466

Query: 121 S-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN-ERINRVIQELGLDKVA 174
                 G V Q+ V+  T T+ EN+ +    R   TM   +K  +  N     + L +  
Sbjct: 467 YLREIIGVVSQEPVLFST-TIAENICYG---RGNVTMDEIKKAVKEANAYEFIMKLPQKF 522

Query: 175 DSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ 234
           D+ VG +  + +SGG+++R +I   L+ +P IL LDE T+ LD+ +   V   L + +++
Sbjct: 523 DTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDK-ARE 580

Query: 235 GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEAL 274
           GRT I   H  R S  +  D +     G ++  G   E +
Sbjct: 581 GRTTIVIAH--RLSTVRNADVIAGFEDGVIVEQGSHSELM 618


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,656,984
Number of Sequences: 37866
Number of extensions: 978979
Number of successful extensions: 2446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2153
Number of HSP's gapped (non-prelim): 161
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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