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Search of human proteins with 62526033
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
(655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 1295 0.0
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 265 1e-70
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 263 5e-70
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 263 5e-70
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 261 1e-69
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 261 1e-69
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 261 1e-69
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 261 1e-69
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 261 1e-69
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 249 7e-66
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 236 4e-62
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 92 2e-18
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 86 1e-16
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 83 9e-16
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 81 3e-15
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 80 5e-15
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 80 6e-15
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 80 6e-15
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 77 5e-14
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 77 7e-14
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 76 9e-14
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 75 1e-13
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 75 1e-13
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 75 2e-13
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 74 3e-13
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 74 6e-13
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 74 6e-13
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 71 4e-12
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 70 8e-12
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 68 2e-11
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 1295 bits (3352), Expect = 0.0
Identities = 655/655 (100%), Positives = 655/655 (100%)
Query: 1 MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE 60
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
Sbjct: 1 MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE 60
Query: 61 KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
Sbjct: 61 KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120
Query: 121 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT 180
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
Sbjct: 121 SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT 180
Query: 181 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF 240
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
Sbjct: 181 QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF 240
Query: 241 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING 300
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
Sbjct: 241 SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING 300
Query: 301 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK 360
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
Sbjct: 301 DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK 360
Query: 361 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS 420
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
Sbjct: 361 ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS 420
Query: 421 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
Sbjct: 421 TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480
Query: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL 540
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
Sbjct: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL 540
Query: 541 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN 600
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
Sbjct: 541 MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN 600
Query: 601 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
Sbjct: 601 NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS 655
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 265 bits (677), Expect = 1e-70
Identities = 163/529 (30%), Positives = 294/529 (55%), Gaps = 21/529 (3%)
Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR
Sbjct: 93 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 151
Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL
Sbjct: 152 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 209
Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++
Sbjct: 210 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 264
Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF
Sbjct: 265 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 324
Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKL-AEIYVNSSFYKETKAELHQL 352
+++ +G+ +++ + + D L + VN + E+ Q
Sbjct: 325 VMEVASGE------YGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQT 378
Query: 353 S--GGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIG 410
G +K ++ S++ S Q + KR+F +++ + + +I + +GL+IG
Sbjct: 379 KRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIG 438
Query: 411 AIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSY 469
+Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +Y
Sbjct: 439 LLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAY 498
Query: 470 FLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAA 529
+L K ++D +P +++ + + IVY+M A F + M + A S+ L I A
Sbjct: 499 YLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA 557
Query: 530 GQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
+ + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF
Sbjct: 558 ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 606
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 263 bits (671), Expect = 5e-70
Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%)
Query: 54 PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111
PC RK K +L ++G + L I+GP+G GKS+ +++LA ++ SG+ G +L+NG
Sbjct: 74 PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132
Query: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170
PR F+ S Y++QDD+++ LTV E + SA L+L+ K E + ++ LGL
Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190
Query: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230
+ ++ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K
Sbjct: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245
Query: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290
+++ GRTII +IHQP +F++FD L +L+ G+ +F G + Y + G HC Y+NP
Sbjct: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305
Query: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350
ADF +++ +G+ + P++ + + + + K++ E +
Sbjct: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345
Query: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408
++ ++ + ++ TS Q + KR+F ++L + + + + VV+G++
Sbjct: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405
Query: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467
IG +Y + +D++ + N G LFF F+++ L F +E +F+ E+++ +Y +
Sbjct: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465
Query: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527
+Y+L K ++D +P +++ +++ IVY+M G + F + A A S+ L I
Sbjct: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524
Query: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587
A + + VAT + + + +++FSG V+ TI ++L W Y S RYGF + +
Sbjct: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583
Query: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646
G+ G+ C C E + + +D+ L+ + + L + +AYL
Sbjct: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636
Query: 647 KLLFLKK 653
L + K
Sbjct: 637 VLRYRVK 643
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 263 bits (671), Expect = 5e-70
Identities = 170/607 (28%), Positives = 317/607 (52%), Gaps = 44/607 (7%)
Query: 54 PC-RKPVEKEILSNING-IMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111
PC RK K +L ++G + L I+GP+G GKS+ +++LA ++ SG+ G +L+NG
Sbjct: 74 PCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRE-SGMKGQILVNGR 132
Query: 112 PRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGL 170
PR F+ S Y++QDD+++ LTV E + SA L+L+ K E + ++ LGL
Sbjct: 133 PRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQ--EVKKELVTEILTALGL 190
Query: 171 DKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKR 230
+ ++ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K
Sbjct: 191 MSCSHTRTAL-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245
Query: 231 MSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNP 290
+++ GRTII +IHQP +F++FD L +L+ G+ +F G + Y + G HC Y+NP
Sbjct: 246 LAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNP 305
Query: 291 ADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELH 350
ADF +++ +G+ + P++ + + + + K++ E +
Sbjct: 306 ADFIIEVASGEYGDL--------------------NPMLFRAVQNGLCAMAEKKSSPEKN 345
Query: 351 QLSG--GEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLV 408
++ ++ + ++ TS Q + KR+F ++L + + + + VV+G++
Sbjct: 346 EVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVL 405
Query: 409 IGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVS 467
IG +Y + +D++ + N G LFF F+++ L F +E +F+ E+++ +Y +
Sbjct: 406 IGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLK 465
Query: 468 SYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAI 527
+Y+L K ++D +P +++ +++ IVY+M G + F + A A S+ L I
Sbjct: 466 AYYLAKTMAD-VPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLI 524
Query: 528 AAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFL 587
A + + VAT + + + +++FSG V+ TI ++L W Y S RYGF + +
Sbjct: 525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIY- 583
Query: 588 GQNFCPGLNATGNNPCNYATCT-GEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYL 646
G+ G+ C C E + + +D+ L+ + + L + +AYL
Sbjct: 584 ------GME-RGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636
Query: 647 KLLFLKK 653
L + K
Sbjct: 637 VLRYRVK 643
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 261 bits (667), Expect = 1e-69
Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)
Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR
Sbjct: 90 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 148
Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL
Sbjct: 149 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 206
Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++
Sbjct: 207 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 261
Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF
Sbjct: 262 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 321
Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
+++ +G E Q+ L+ + E +S ++ AE++
Sbjct: 322 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 362
Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
++ + E S++ S Q + KR+F +++ + + +I + +GL+I
Sbjct: 363 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 422
Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +
Sbjct: 423 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 482
Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I
Sbjct: 483 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 541
Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF
Sbjct: 542 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 591
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 261 bits (667), Expect = 1e-69
Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)
Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR
Sbjct: 71 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 129
Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL
Sbjct: 130 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 187
Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++
Sbjct: 188 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 242
Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF
Sbjct: 243 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 302
Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
+++ +G E Q+ L+ + E +S ++ AE++
Sbjct: 303 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 343
Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
++ + E S++ S Q + KR+F +++ + + +I + +GL+I
Sbjct: 344 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 403
Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +
Sbjct: 404 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 463
Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I
Sbjct: 464 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 522
Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF
Sbjct: 523 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 572
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 261 bits (667), Expect = 1e-69
Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)
Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR
Sbjct: 95 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 153
Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL
Sbjct: 154 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 211
Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++
Sbjct: 212 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 266
Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF
Sbjct: 267 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 326
Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
+++ +G E Q+ L+ + E +S ++ AE++
Sbjct: 327 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 367
Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
++ + E S++ S Q + KR+F +++ + + +I + +GL+I
Sbjct: 368 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 427
Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +
Sbjct: 428 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 487
Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I
Sbjct: 488 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 546
Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF
Sbjct: 547 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 596
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 261 bits (667), Expect = 1e-69
Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)
Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR
Sbjct: 104 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 162
Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL
Sbjct: 163 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 220
Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++
Sbjct: 221 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 275
Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF
Sbjct: 276 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 335
Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
+++ +G E Q+ L+ + E +S ++ AE++
Sbjct: 336 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 376
Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
++ + E S++ S Q + KR+F +++ + + +I + +GL+I
Sbjct: 377 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 436
Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +
Sbjct: 437 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 496
Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I
Sbjct: 497 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 555
Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF
Sbjct: 556 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 605
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 261 bits (667), Expect = 1e-69
Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)
Query: 56 RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114
RK K +L I+G G L AI+GP+G GKS+L+++LA ++ +G+ G VLING PR
Sbjct: 93 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 151
Query: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173
F+ S Y++QDD+++ LTV+E + SA L+L + + E + ++ LGL
Sbjct: 152 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 209
Query: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233
A+++ G+ +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++ V+ L+K +++
Sbjct: 210 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 264
Query: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293
GR+II +IHQP +F+LFD L +L+ G+ ++ G + Y G +C Y+NPADF
Sbjct: 265 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 324
Query: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351
+++ +G E Q+ L+ + E +S ++ AE++
Sbjct: 325 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 365
Query: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409
++ + E S++ S Q + KR+F +++ + + +I + +GL+I
Sbjct: 366 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 425
Query: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468
G +Y G+ N++ + + +G LFF F+++ L F +E +F+ E+++ +Y + +
Sbjct: 426 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 485
Query: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528
Y+L K ++D +P +++ + + IVY+M A F + M + A S+ L I
Sbjct: 486 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 544
Query: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578
A + + VAT + + + +++FSG V+ TI ++L W+ Y S RYGF
Sbjct: 545 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 594
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
Length = 651
Score = 249 bits (635), Expect = 7e-66
Identities = 179/611 (29%), Positives = 317/611 (51%), Gaps = 47/611 (7%)
Query: 13 SQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMK 72
SQ + G PATA + + G + + +++ +RV+ CR+ ++IL +++ ++
Sbjct: 21 SQSSLEGAPATAP---EPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVE 77
Query: 73 PG-LNAILGPTGGGKSSLLDVLAARKDPSG-LSGDVLING-APRPANFKCNSGYVVQDDV 129
G + ILG +G GK++LLD ++ R +G G+V +NG A R F+ YV+Q D
Sbjct: 78 SGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDT 137
Query: 130 VMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGG 189
++ +LTVRE L ++A L + + +++ V+ EL L VAD +G + G+S G
Sbjct: 138 LLSSLTVRETLHYTALLAIRRGNPGSFQ-KKVEAVMAELSLSHVADRLIGNYSLGGISTG 196
Query: 190 ERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSI 249
ER+R SI +L+ DP ++ DEPTTGLD TAN +++LL ++++ R ++ +IHQPR +
Sbjct: 197 ERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSEL 256
Query: 250 FKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNR 309
F+LFD + +L+ G L+F G E L +F GY C ++NP DF++D+ + D+ ++
Sbjct: 257 FQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQ----SK 312
Query: 310 EEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISY 369
E + IE SK+ ++ + Y S+ +T L E+ K + + +
Sbjct: 313 ERE------IETSKR----VQMIESAYKKSAICHKT------LKNIERMKHLKTLPMVPF 356
Query: 370 TT----SFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDST---- 421
T +L + +R +NL+ N A I +++ +++GL + ++F L+ S
Sbjct: 357 KTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFL--LFFVLRVRSNVLKG 414
Query: 422 GIQNRAGVLF-FLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480
IQ+R G+L+ F+ ++AV LF V + + E G Y+ L L +LP
Sbjct: 415 AIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYAL-HVLP 473
Query: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLM---MVAYSASSMALAIAAGQSVVSVA 537
++ ++IF+ + Y+ LGL P+ F L+ ++ + + L I ++V+
Sbjct: 474 FSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSV 533
Query: 538 TLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPG--- 594
L++I V ++ SG L N+ + + YF+ +Y L NEF G NF G
Sbjct: 534 VALLSIAGV--LVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSN 591
Query: 595 LNATGNNPCNY 605
++ T N C +
Sbjct: 592 VSVTTNPMCAF 602
>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
Length = 673
Score = 236 bits (603), Expect = 4e-62
Identities = 166/585 (28%), Positives = 289/585 (49%), Gaps = 27/585 (4%)
Query: 77 AILGPTGGGKSSLLDVLAARKDPSGL-SGDVLINGAPRPANF--KCNSGYVVQDDVVMGT 133
AI+G +G G++SLLDV+ R + SG + ING P KC + +V Q + ++
Sbjct: 102 AIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVA-HVRQHNQLLPN 160
Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
LTVRE L F A +RL T + ++++R+ VI EL L + AD++VG ++RG+SGGER+R
Sbjct: 161 LTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRR 220
Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
SIG++L+ +P IL LDEPT+GLDS TA+ ++ L R++K R ++ S+HQPR IF+LF
Sbjct: 221 VSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLF 280
Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDF 313
D + L+ SG ++ G AQ + YF + GY C Y+NPADF++D+ + D +RE++
Sbjct: 281 DLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR----SREQEL 336
Query: 314 KATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQ---LSGGEKKKKITVFKEISYT 370
E + +EK+ ++ + +K +L + + +
Sbjct: 337 ATRE--KAQSLAALFLEKVRDL--DDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKM 392
Query: 371 TSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVL 430
Q + +R N + + ++ + IG +YFG + + A +L
Sbjct: 393 PGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALL 452
Query: 431 FFLTTNQCFSSV-SAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIF 489
F + F+ + + E+ + +E G Y YF K+L + LP II+
Sbjct: 453 FMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGE-LPEHCAYIIIY 511
Query: 490 TCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMM 549
Y++ L+P F + + +V + MALA AA +A+ +
Sbjct: 512 GMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFY 571
Query: 550 IFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNF-CPGLNATGNNPCNYATC 608
+ G ++NL+++ + +W+ S R+ F L +F + + P N T
Sbjct: 572 LAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLT-------IAV 624
Query: 609 TGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKK 653
+G++ L +D P L+ ++ + + F+ + Y+ L F+K+
Sbjct: 625 SGDKILSVMELDSYP--LYAIYLIVIGLSGGFMVLYYVSLRFIKQ 667
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 92.0 bits (227), Expect = 2e-18
Identities = 57/170 (33%), Positives = 95/170 (55%), Gaps = 12/170 (7%)
Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA---NFKCNSGYVVQDDVVM 131
+ A+LG +G GK++LL++L+ P+ S V + R A N +G+ Q +V
Sbjct: 512 ITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQF 571
Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
G LTV+ENL+ A ++ + HE + + RV+QEL ++ + D + +SGG+
Sbjct: 572 GFLTVKENLRLFAKIK---GILPHEVEKEVQRVVQELEMENIQDI-----LAQNLSGGQN 623
Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241
++ + G+ ++ DP +L LDEPT GLD + + + LLK K R I+FS
Sbjct: 624 RKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSDRVILFS 672
Score = 58.5 bits (140), Expect = 2e-08
Identities = 57/238 (23%), Positives = 110/238 (46%), Gaps = 21/238 (8%)
Query: 44 YRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGL 102
Y K K+ F +K + N++ +K G + +LG G GKS+ + ++ P+
Sbjct: 1292 YAGKKKNCFSKRKKKIATR---NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPT-- 1346
Query: 103 SGDVLINGAP--RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER 160
+G V++ G+ P F GY Q++ + LTVR++L+ AA++ + +
Sbjct: 1347 AGQVILKGSGGGEPLGFL---GYCPQENALWPNLTVRQHLEVYAAVK---GLRKGDAMIA 1400
Query: 161 INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSST 220
I R++ L L + V T +S G +++ + ++ +PS++ LDEP+TG+D
Sbjct: 1401 ITRLVDALKLQDQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEG 1455
Query: 221 ANAVLLLLKRMSKQ-GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
+ +++ + R + + H + D + ++ SGRL G Q F
Sbjct: 1456 QQQMWQVIRATFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1512
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 85.9 bits (211), Expect = 1e-16
Identities = 58/198 (29%), Positives = 108/198 (54%), Gaps = 13/198 (6%)
Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131
+ A+LG G GK++++ +L P+ SG ++ING + + G Q D+++
Sbjct: 3870 ITALLGTNGAGKTTIISMLTGLHPPT--SGTIIINGKNLQTDLSRVRMELGVCPQQDILL 3927
Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
LTVRE+L A+++ A T E ++++N+ +Q++ L + + R +SGG +
Sbjct: 3928 DNLTVREHLLLFASIK-APQWTKKELHQQVNQTLQDVDLTQHQHKQT-----RALSGGLK 3981
Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
++ S+G+ + + LDEPT+G+D + +++ +L + ++GRTIIF+ H
Sbjct: 3982 RKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKY-REGRTIIFTTHH-LDEAEA 4039
Query: 252 LFDSLTLLASGRLMFHGP 269
L D + +L GRL GP
Sbjct: 4040 LSDRVAVLQHGRLRCCGP 4057
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 17/182 (9%)
Query: 69 GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSG------ 122
GI K +LG G GKS+ +L + S SG +I A ++G
Sbjct: 4743 GIPKGECFGLLGVNGAGKSTTFKMLNG--EVSLTSGHAIIRTPMGDAVDLSSAGTAGVLI 4800
Query: 123 -YVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQ 181
Y Q D + LT E+L + +LR + E +I+ L L+ AD V T
Sbjct: 4801 GYCPQQDALDELLTGWEHLYYYCSLR---GIPRQCIPEVAGDLIRRLHLEAHADKPVATY 4857
Query: 182 FIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFS 241
SGG +++ S + L+ P IL LDEP++G+D + + + + ++G + +
Sbjct: 4858 -----SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLT 4912
Query: 242 IH 243
H
Sbjct: 4913 SH 4914
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 82.8 bits (203), Expect = 9e-16
Identities = 69/225 (30%), Positives = 113/225 (50%), Gaps = 20/225 (8%)
Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVM 131
+ +LG G GK++ L +L P+ SG I+G + + + G Q D++
Sbjct: 561 ITVLLGHNGAGKTTTLSMLTGLFPPT--SGRAYISGYEISQDMVQIRKSLGLCPQHDILF 618
Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
LTV E+L F A L+ ++ + E + +++ +GL+ +S+ R +SGG R
Sbjct: 619 DNLTVAEHLYFYAQLK---GLSRQKCPEEVKQMLHIIGLEDKWNSRS-----RFLSGGMR 670
Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
++ SIG+ LI +L LDEPT+G+D+ + A+ LL+R K RTI+ + H +
Sbjct: 671 RKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADL- 728
Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHC----EAYNNPAD 292
L D + ++A G L G + L AGYH E + NP D
Sbjct: 729 LGDRIAIMAKGELQCCG-SSLFLKQKYGAGYHMTLVKEPHCNPED 772
Score = 66.2 bits (160), Expect = 9e-11
Identities = 57/212 (26%), Positives = 94/212 (44%), Gaps = 15/212 (7%)
Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
+LG G GK++ +L + S SGD + G + + GY Q D ++ +
Sbjct: 1414 LLGFNGAGKTTTFKMLTGEE--SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHM 1471
Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
T RE L A LR + + ++ L L+ A+ + +R SGG +++
Sbjct: 1472 TGREMLVMYARLR---GIPERHIGACVENTLRGLLLEPHAN-----KLVRTYSGGNKRKL 1523
Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
S G+ LI +P+++FLDEP+TG+D + + R + G+ II + H L
Sbjct: 1524 STGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSME-ECEALCT 1582
Query: 255 SLTLLASGRLMFHGPAQEALGYFESAGYHCEA 286
L ++ G+ G Q F S GY A
Sbjct: 1583 RLAIMVQGQFKCLGSPQHLKSKFGS-GYSLRA 1613
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 80.9 bits (198), Expect = 3e-15
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 14/218 (6%)
Query: 75 LNAILGPTGGGKSSLLDVLAARK---DPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVM 131
+ AILG G GKS+LL++L+ + S + ++ + N G+ Q +
Sbjct: 422 ITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQF 481
Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
LTVRENL+ A ++ + E + + R+I EL + + D + +SGG++
Sbjct: 482 DFLTVRENLRVFAKIK---GIQPKEVEQEVKRIIMELDMQSIQDI-----IAKKLSGGQK 533
Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
++ ++G+ ++ DP +L LDEPT GLD + + V LLK K R I+FS Q
Sbjct: 534 RKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRLILFST-QFMDEADI 591
Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289
L D L++G+L G + L GYH + N
Sbjct: 592 LADRKVFLSNGKLKCAG-SSLFLKRKWGIGYHLSLHRN 628
Score = 55.1 bits (131), Expect = 2e-07
Identities = 57/245 (23%), Positives = 115/245 (46%), Gaps = 22/245 (8%)
Query: 40 HNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKD 98
H Y K KS F +K + + N++ +K G + +LG G GKS+ + ++
Sbjct: 1202 HKEYYETK-KSCFSTRKKKIA---IRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTK 1257
Query: 99 PSGLSGDVLINGAPRPANFKCNS-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMT 153
P+ +G V++ G+ + ++ GY Q++ + LT++E+L+ AA++ +
Sbjct: 1258 PT--AGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVK---GLG 1312
Query: 154 NHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPT 213
+ I+R+++ L L + + V T +S G +++ + ++ +PS++ LDEP
Sbjct: 1313 KEDAALSISRLVEALKLQEQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPF 1367
Query: 214 TGLDSSTANAVLLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQE 272
TG+D + +L+ K + R + + H + D + ++ SG L G Q
Sbjct: 1368 TGMDPEGQQQMWQILQATVKNKERGTLLTTHY-MSEAEAVCDRMAMMVSGTLRCIGSIQH 1426
Query: 273 ALGYF 277
F
Sbjct: 1427 LKNKF 1431
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 80.5 bits (197), Expect = 5e-15
Identities = 60/208 (28%), Positives = 99/208 (47%), Gaps = 15/208 (7%)
Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
+LG G GK+S ++ D G+ ++ G A P+ + GY Q D + L
Sbjct: 1825 LLGVNGAGKTSTFRMVTG--DTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882
Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
T RE+L+ A LR + + + + LGL AD GT SGG +++
Sbjct: 1883 TGREHLELLARLR---GVPEAQVAQTAGSGLARLGLSWYADRPAGTY-----SGGNKRKL 1934
Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
+ + L+ DP+++FLDEPTTG+D S + L + ++GR+++ + H L
Sbjct: 1935 ATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSME-ECEALCS 1993
Query: 255 SLTLLASGRLMFHGPAQEALGYFESAGY 282
L ++ +GR G Q G F +AG+
Sbjct: 1994 RLAIMVNGRFRCLGSPQHLKGRF-AAGH 2020
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/192 (30%), Positives = 102/192 (53%), Gaps = 13/192 (6%)
Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP-ANFKCNSGYVVQDDVVMGT 133
+ A LG G GK++ L +L+ PSG S +L + A + + G Q +V+
Sbjct: 836 ITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDM 895
Query: 134 LTVRENLQFSAALR-LATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERK 192
LTV E++ F L+ L+ + E++ R++Q++GL V+ V T R +SGG ++
Sbjct: 896 LTVDEHVWFYGRLKGLSAAVVGPEQD----RLLQDVGL--VSKQSVQT---RHLSGGMQR 946
Query: 193 RTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKL 252
+ S+ + + ++ LDEPT G+D ++ + LL + ++GRT+I S H + L
Sbjct: 947 KLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKY-REGRTLILSTHHLDEAEL-L 1004
Query: 253 FDSLTLLASGRL 264
D + ++A GRL
Sbjct: 1005 GDRVAVVAGGRL 1016
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 80.1 bits (196), Expect = 6e-15
Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%)
Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
+LG G GK+S +L D S G+ +NG + + GY Q D + L
Sbjct: 2086 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2143
Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
T RE+LQ LR ++ ++ + +++L L K AD GT SGG +++
Sbjct: 2144 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2195
Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
S + LI P+ +FLDEPTTG+D + L+ + K GR+++ + H L
Sbjct: 2196 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2254
Query: 255 SLTLLASGRLMFHGPAQEALGYF 277
L ++ +GRL G Q F
Sbjct: 2255 RLAIMVNGRLRCLGSIQHLKNRF 2277
Score = 70.1 bits (170), Expect = 6e-12
Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%)
Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133
+ LG G GK++ + +L P+ SG I G + N G Q +V+
Sbjct: 1022 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1079
Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
LTV E+L F + L+ +M E ++++I++L L S V T +SGG +++
Sbjct: 1080 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1131
Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
S+ + + + LDEPT G+D A+ L+ + K GRTI+ S H + L
Sbjct: 1132 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1189
Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292
D + +++ G+L G G + GY PA+
Sbjct: 1190 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1227
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 80.1 bits (196), Expect = 6e-15
Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 14/203 (6%)
Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
+LG G GK+S +L D S G+ +NG + + GY Q D + L
Sbjct: 2116 LLGVNGAGKTSTFKMLTG--DESTTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDEL 2173
Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
T RE+LQ LR ++ ++ + +++L L K AD GT SGG +++
Sbjct: 2174 TAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADKPAGTY-----SGGNKRKL 2225
Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
S + LI P+ +FLDEPTTG+D + L+ + K GR+++ + H L
Sbjct: 2226 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSME-ECEALCT 2284
Query: 255 SLTLLASGRLMFHGPAQEALGYF 277
L ++ +GRL G Q F
Sbjct: 2285 RLAIMVNGRLRCLGSIQHLKNRF 2307
Score = 70.1 bits (170), Expect = 6e-12
Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 16/219 (7%)
Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGT 133
+ LG G GK++ + +L P+ SG I G + N G Q +V+
Sbjct: 1052 SFLGHNGAGKTTTMSILTGLFPPT--SGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1109
Query: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
LTV E+L F + L+ +M E ++++I++L L S V T +SGG +++
Sbjct: 1110 LTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLELSNKRHSLVQT-----LSGGMKRK 1161
Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
S+ + + + LDEPT G+D A+ L+ + K GRTI+ S H + L
Sbjct: 1162 LSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKY-KPGRTILLSTHHMDEADL-LG 1219
Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPAD 292
D + +++ G+L G G + GY PA+
Sbjct: 1220 DRIAIISHGKLKCCGSPLFLKGTY-GDGYRLTLVKRPAE 1257
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 77.0 bits (188), Expect = 5e-14
Identities = 64/218 (29%), Positives = 105/218 (48%), Gaps = 14/218 (6%)
Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF---KCNSGYVVQDDVVM 131
+ AILG +G GKSSLL++L P+ S + + + +G Q +V
Sbjct: 509 ITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQF 568
Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
LTV+ENL A ++ + E + + R++ EL + + D+ + +S G++
Sbjct: 569 DILTVKENLSLFAKIK---GIHLKEVEQEVQRILLELDMQNIQDN-----LAKHLSEGQK 620
Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
++ + G+ ++ DP IL LDEPTTGLD + + V LL R + I+FS Q
Sbjct: 621 RKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLL-RERRADHVILFST-QSMDEADI 678
Query: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289
L D ++++GRL G + L GYH + N
Sbjct: 679 LADRKVIMSNGRLKCAGSSM-FLKRRWGLGYHLSLHRN 715
Score = 56.6 bits (135), Expect = 7e-08
Identities = 53/217 (24%), Positives = 106/217 (48%), Gaps = 16/217 (7%)
Query: 57 KPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPA 115
K +K NI+ ++ G + +LGP G GKSS + +++ P+ +G+V + G +
Sbjct: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPT--AGEVELKGC---S 1350
Query: 116 NFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVAD 175
+ + GY Q++V+ LT+RE+L+ AA++ + + I R++ L + +
Sbjct: 1351 SVLGHLGYCPQENVLWPMLTLREHLEVYAAVK---GLRKADARLAIARLVSAFKLHEQLN 1407
Query: 176 SKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ- 234
V + ++ G ++ + L+ + +L LDEP+TG+D + + ++ + K
Sbjct: 1408 VPV-----QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNT 1462
Query: 235 GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271
R ++ + H L D + ++ SGRL G Q
Sbjct: 1463 ERGVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGSIQ 1498
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 76.6 bits (187), Expect = 7e-14
Identities = 60/203 (29%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFK---CNSGYVVQDDVVMGTL 134
+LG G GKSS +L D + GD +N +N N GY Q D + L
Sbjct: 1944 LLGVNGAGKSSTFKMLTG--DTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELL 2001
Query: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
T RE+++F A LR + E + I++LGL K G ++ SGG +++
Sbjct: 2002 TGREHVEFFALLR---GVPEKEVGKVGEWAIRKLGL-----VKYGEKYAGNYSGGNKRKL 2053
Query: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
S M LI P ++FLDEPTTG+D + + K+GR+++ + H L
Sbjct: 2054 STAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSME-ECEALCT 2112
Query: 255 SLTLLASGRLMFHGPAQEALGYF 277
+ ++ +GR G Q F
Sbjct: 2113 RMAIMVNGRFRCLGSVQHLKNRF 2135
Score = 69.3 bits (168), Expect = 1e-11
Identities = 64/244 (26%), Positives = 109/244 (44%), Gaps = 21/244 (8%)
Query: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP---RPANFKCNSGYVVQDDVVM 131
+ + LG G GK++ + +L P+ SG I G + + N G Q +V+
Sbjct: 928 ITSFLGHNGAGKTTTMSILTGLFPPT--SGTAYILGKDIRSEMSTIRQNLGVCPQHNVLF 985
Query: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
LTV E++ F A RL H K E ++++ LD S +SGG +
Sbjct: 986 DMLTVEEHIWFYA--RLKGLSEKHVKAE-----MEQMALDVGLPSSKLKSKTSQLSGGMQ 1038
Query: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
++ S+ + + ++ LDEPT G+D + + LL + +QGRTII S H +
Sbjct: 1039 RKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY-RQGRTIILSTHHMDEADV- 1096
Query: 252 LFDSLTLLASGRLMFHGPA---QEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALN 308
L D + +++ G+L G + + LG GY+ + L S+ V+
Sbjct: 1097 LGDRIAIISHGKLCCVGSSLFLKNQLG----TGYYLTLVKKDVESSLSSCRNSSSTVSYL 1152
Query: 309 REED 312
++ED
Sbjct: 1153 KKED 1156
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 76.3 bits (186), Expect = 9e-14
Identities = 66/246 (26%), Positives = 119/246 (48%), Gaps = 28/246 (11%)
Query: 37 LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95
++F N+C+ + GF E+L + + PG + A++G +GGGK+++ +L
Sbjct: 455 VTFQNVCFSYPCRPGF---------EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLER 505
Query: 96 RKDPSGLSGDVLINGAPR----PANFKCNS-GYVVQDDVVMGTLTVRENLQFSAALRLAT 150
DP+ +G V+++G P+ + G++ Q+ V+ GT T+ EN++F
Sbjct: 506 FYDPT--AGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT-TIMENIRFGKLEASDE 562
Query: 151 TMTNHEKNERINRVIQEL--GLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILF 208
+ + + I G + V + T +SGG+++R +I LI P++L
Sbjct: 563 EVYTAAREANAHEFITSFPEGYNTVVGERGTT-----LSGGQKQRLAIARALIKQPTVLI 617
Query: 209 LDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG 268
LDE T+ LD+ + V L R S GRT++ H R S + + ++A GR+ G
Sbjct: 618 LDEATSALDAESERVVQEALDRAS-AGRTVLVIAH--RLSTVRGAHCIVVMADGRVWEAG 674
Query: 269 PAQEAL 274
+E L
Sbjct: 675 THEELL 680
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 75.5 bits (184), Expect = 1e-13
Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 21/230 (9%)
Query: 61 KEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF-- 117
K + N+N G + ++LGP G GK++ + +L S +G + + G +
Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS--AGTIFVYGKDIKTDLHT 1097
Query: 118 -KCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADS 176
+ N G +Q DV+ LT +E+L ++++ T + +E + R +++ GL
Sbjct: 1098 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRHK 1156
Query: 177 KVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR 236
+VGT +SGG +++ SI + LI ++ LDEP+TG+D + ++ ++ + +K R
Sbjct: 1157 RVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTAR 1210
Query: 237 TIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGP---AQEALGYFESAGYH 283
TII S H + L D + L G L G +EA G GYH
Sbjct: 1211 TIILSTHHLDEAEV-LSDRIAFLEQGGLRCCGSPFYLKEAFG----DGYH 1255
Score = 57.0 bits (136), Expect = 5e-08
Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 18/226 (7%)
Query: 59 VEKEILSNIN---GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLI-NGAPRP 114
+ K+I++ N GI +LG G GK+++ +L PS SG++LI N
Sbjct: 1948 IHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS--SGNILIRNKTGSL 2005
Query: 115 ANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
+ +S GY Q+D + +TV E+L F A + + + E ++++++ L L
Sbjct: 2006 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLM 2062
Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
D S G +++ S + LI PSIL LDEP++G+D + + ++
Sbjct: 2063 PFKDRATSM-----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEE 2117
Query: 232 SKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
+ ++I + H L L ++ +G+ G Q F
Sbjct: 2118 VQNKCSVILTSHSME-ECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2162
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 75.5 bits (184), Expect = 1e-13
Identities = 64/230 (27%), Positives = 112/230 (48%), Gaps = 21/230 (9%)
Query: 61 KEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANF-- 117
K + N+N G + ++LGP G GK++ + +L S +G + + G +
Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS--AGTIFVYGKDIKTDLHT 1415
Query: 118 -KCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADS 176
+ N G +Q DV+ LT +E+L ++++ T + +E + R +++ GL
Sbjct: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRHK 1474
Query: 177 KVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGR 236
+VGT +SGG +++ SI + LI ++ LDEP+TG+D + ++ ++ + +K R
Sbjct: 1475 RVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTAR 1528
Query: 237 TIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGP---AQEALGYFESAGYH 283
TII S H + L D + L G L G +EA G GYH
Sbjct: 1529 TIILSTHHLDEAEV-LSDRIAFLEQGGLRCCGSPFYLKEAFG----DGYH 1573
Score = 57.0 bits (136), Expect = 5e-08
Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 18/226 (7%)
Query: 59 VEKEILSNIN---GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLI-NGAPRP 114
+ K+I++ N GI +LG G GK+++ +L PS SG++LI N
Sbjct: 2266 IHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS--SGNILIRNKTGSL 2323
Query: 115 ANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
+ +S GY Q+D + +TV E+L F A + + + E ++++++ L L
Sbjct: 2324 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLM 2380
Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
D S G +++ S + LI PSIL LDEP++G+D + + ++
Sbjct: 2381 PFKDRATSM-----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEE 2435
Query: 232 SKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYF 277
+ ++I + H L L ++ +G+ G Q F
Sbjct: 2436 VQNKCSVILTSHSME-ECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 75.1 bits (183), Expect = 2e-13
Identities = 87/322 (27%), Positives = 141/322 (43%), Gaps = 47/322 (14%)
Query: 37 LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAA 95
+ FHN+ + P R V+ IL+++N ++KPG + A++GP+G GKS+ L ++
Sbjct: 420 IEFHNVTFHY-------PSRPEVK--ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQR 470
Query: 96 RKDPSGLSGDVLINGAP-RPANFKC---NSGYVVQDDVVMGTLTVRENLQFSAALRLATT 151
DP G V ++G R N + G V Q+ V+ T T+ EN+++
Sbjct: 471 FYDPC--EGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFST-TIAENIRYGREDATMED 527
Query: 152 MTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDE 211
+ K I +L + D+ VG + +SGG+++R +I LI +P IL LD
Sbjct: 528 IVQAAKEANAYNFIMDL--PQQFDTLVGEGGGQ-MSGGQKQRVAIARALIRNPKILLLDM 584
Query: 212 PTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQ 271
T+ LD+ + V +L ++ + G TII H R S + D++ HG A
Sbjct: 585 ATSALDNESEAMVQEVLSKI-QHGHTIISVAH--RLSTVRAADTIIGFE------HGTAV 635
Query: 272 EALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEK 331
E G H E +F + ALN E+ ATE +
Sbjct: 636 E-------RGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATE-----------DDM 677
Query: 332 LAEIYVNSSFYKETKAELHQLS 353
LA + S+ +A + Q S
Sbjct: 678 LARTFSRGSYQDSLRASIRQRS 699
Score = 65.9 bits (159), Expect = 1e-10
Identities = 60/230 (26%), Positives = 115/230 (50%), Gaps = 32/230 (13%)
Query: 60 EKEILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPAN- 116
+ ++L+ ++ + PG A +G +G GKS+ + +L DP G V+I+G + N
Sbjct: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPD--QGKVMIDGHDSKKVNV 1149
Query: 117 --FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQE------- 167
+ N G V Q+ V+ ++ +N+++ ++ K + RVI
Sbjct: 1150 QFLRSNIGIVSQEPVLFAC-SIMDNIKYG----------DNTKEIPMERVIAAAKQAQLH 1198
Query: 168 ---LGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224
+ L + ++ VG+Q + +S GE++R +I ++ DP IL LDE T+ LD+ + V
Sbjct: 1199 DFVMSLPEKYETNVGSQGSQ-LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV 1257
Query: 225 LLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEAL 274
+ L + +++GRT I H R S + D + ++A G ++ G +E +
Sbjct: 1258 QVALDK-AREGRTCIVIAH--RLSTIQNADIIAVMAQGVVIEKGTHEELM 1304
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 74.3 bits (181), Expect = 3e-13
Identities = 60/220 (27%), Positives = 106/220 (48%), Gaps = 18/220 (8%)
Query: 52 FLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGA 111
F PC +P + NI + + A LG G GK++ L +L P+ SG VL+ G
Sbjct: 938 FEPCGRPAVDRL--NIT-FYENQITAFLGHNGAGKTTTLSILTGLLPPT--SGTVLVGGR 992
Query: 112 PRPANFKC---NSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQEL 168
+ + G Q +++ LTV E++ F A L+ + E + ++++
Sbjct: 993 DIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLK---GKSQEEAQLEMEAMLEDT 1049
Query: 169 GLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLL 228
GL + + + +SGG +++ S+ + + D ++ LDEPT+G+D + ++ LL
Sbjct: 1050 GLHHKRNEEA-----QDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL 1104
Query: 229 KRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHG 268
+ + GRTII S H + L D + ++A GRL G
Sbjct: 1105 LKY-RSGRTIIMSTHHMDEADL-LGDRIAIIAQGRLYCSG 1142
Score = 72.8 bits (177), Expect = 9e-13
Identities = 64/226 (28%), Positives = 96/226 (42%), Gaps = 16/226 (7%)
Query: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFK---CNSGYVVQDDVVMGTL 134
+LG G GK++ +L D + SGD + G N N GY Q D + L
Sbjct: 1970 LLGVNGAGKTTTFKMLTG--DTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELL 2027
Query: 135 TVRENLQFSAALRLATTMTNHEKNERI-NRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
T RE+L A LR E+ E++ N I+ LGL AD GT SGG +++
Sbjct: 2028 TGREHLYLYARLRGVPA----EEIEKVANWSIKSLGLTVYADCLAGTY-----SGGNKRK 2078
Query: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
S + LI P ++ LDEPTTG+D + ++ + ++GR ++ + H L
Sbjct: 2079 LSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSME-ECEALC 2137
Query: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIIN 299
L ++ G G Q F +P D L +N
Sbjct: 2138 TRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLN 2183
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 73.6 bits (179), Expect = 6e-13
Identities = 53/192 (27%), Positives = 98/192 (51%), Gaps = 13/192 (6%)
Query: 56 RKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVL---INGA 111
+K E L N++ I + + A+LG +G GKS+L+++L PS + ++
Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548
Query: 112 PRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
+ G Q D+ LTV ENL A+++ + + + + +V+ +L +
Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK---GIPANNIIQEVQKVLLDLDMQ 605
Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
+ D++ + +SGG++++ S+G+ ++ +P IL LDEPT G+D + + V LLK
Sbjct: 606 TIKDNQA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK-Y 659
Query: 232 SKQGRTIIFSIH 243
K R +FS H
Sbjct: 660 RKANRVTVFSTH 671
Score = 62.0 bits (149), Expect = 2e-09
Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 17/242 (7%)
Query: 49 KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSG---LSG 104
K FL RK V+K I+ +K G + +LGP G GKS+++++L +P+ G
Sbjct: 1302 KKDFLLSRK-VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLG 1360
Query: 105 DVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164
D + + KC GY Q + + T++E+ + A++ M+ + E I+R+
Sbjct: 1361 DYSSETSEDDDSLKC-MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRI 1416
Query: 165 IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224
L L + V + + G +++ + ++ +P I LDEP+TG+D +
Sbjct: 1417 THALDLKEHLQKTV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHM 1471
Query: 225 LLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYH 283
++ K + R I + H + D + ++ SG+L G Q F GY
Sbjct: 1472 WRAIRTAFKNRKRAAILTTHYME-EAEAVCDRVAIMVSGQLRCIGTVQHLKSKF-GKGYF 1529
Query: 284 CE 285
E
Sbjct: 1530 LE 1531
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 73.6 bits (179), Expect = 6e-13
Identities = 53/192 (27%), Positives = 98/192 (51%), Gaps = 13/192 (6%)
Query: 56 RKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVL---INGA 111
+K E L N++ I + + A+LG +G GKS+L+++L PS + ++
Sbjct: 489 KKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEI 548
Query: 112 PRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLD 171
+ G Q D+ LTV ENL A+++ + + + + +V+ +L +
Sbjct: 549 DEMFEARKMIGICPQLDIHFDVLTVEENLSILASIK---GIPANNIIQEVQKVLLDLDMQ 605
Query: 172 KVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRM 231
+ D++ + +SGG++++ S+G+ ++ +P IL LDEPT G+D + + V LLK
Sbjct: 606 TIKDNQA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK-Y 659
Query: 232 SKQGRTIIFSIH 243
K R +FS H
Sbjct: 660 RKANRVTVFSTH 671
Score = 62.0 bits (149), Expect = 2e-09
Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 17/242 (7%)
Query: 49 KSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSG---LSG 104
K FL RK V+K I+ +K G + +LGP G GKS+++++L +P+ G
Sbjct: 1302 KKDFLLSRK-VKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLG 1360
Query: 105 DVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164
D + + KC GY Q + + T++E+ + A++ M+ + E I+R+
Sbjct: 1361 DYSSETSEDDDSLKC-MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRI 1416
Query: 165 IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAV 224
L L + V + + G +++ + ++ +P I LDEP+TG+D +
Sbjct: 1417 THALDLKEHLQKTV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHM 1471
Query: 225 LLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYH 283
++ K + R I + H + D + ++ SG+L G Q F GY
Sbjct: 1472 WRAIRTAFKNRKRAAILTTHYME-EAEAVCDRVAIMVSGQLRCIGTVQHLKSKF-GKGYF 1529
Query: 284 CE 285
E
Sbjct: 1530 LE 1531
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 70.9 bits (172), Expect = 4e-12
Identities = 64/250 (25%), Positives = 120/250 (48%), Gaps = 13/250 (5%)
Query: 31 FTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNIN-GIMKPGLNAILGPTGGGKSSL 89
F EG +L+ + ++ K+ E I + + I + A++GP+G GKS++
Sbjct: 477 FNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTV 536
Query: 90 LDVLAARKDPSGLSGDVLINGAP----RPANFKCNSGYVVQDDVVMGTLTVRENLQFSAA 145
L +L DP+ SG + ++G P + G V Q+ ++ + ++ EN+ + A
Sbjct: 537 LSLLLRLYDPA--SGTISLDGHDIRQLNPVWLRSKIGTVSQEPILF-SCSIAENIAYGAD 593
Query: 146 LRLATTMTNHEKNERI-NRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDP 204
+ T ++ + N V + ++ VG + + +SGG+++R +I L+ +P
Sbjct: 594 DPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVL-LSGGQKQRIAIARALLKNP 652
Query: 205 SILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRL 264
IL LDE T+ LD+ V L R+ GRT++ H R S K + + +L G++
Sbjct: 653 KILLLDEATSALDAENEYLVQEALDRL-MDGRTVLVIAH--RLSTIKNANMVAVLDQGKI 709
Query: 265 MFHGPAQEAL 274
+G +E L
Sbjct: 710 TEYGKHEELL 719
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 69.7 bits (169), Expect = 8e-12
Identities = 60/206 (29%), Positives = 105/206 (50%), Gaps = 19/206 (9%)
Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPANFKCNSGY--VVQDDVVMGT 133
A++G +G GKS+++ +L DP L+G VL++G + N + + +V + ++
Sbjct: 1067 ALVGSSGCGKSTVVQLLERFYDP--LAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFD 1124
Query: 134 LTVRENLQFSAALRLATT--MTNHEKNERINRVIQELG---LDKVADSKVGTQFIRGVSG 188
++ EN+ + R+ + + K I+ I+ L KV D GTQ +SG
Sbjct: 1125 CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDK--GTQ----LSG 1178
Query: 189 GERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYS 248
G+++R +I L+ P IL LDE T+ LD+ + V L + +++GRT I H R S
Sbjct: 1179 GQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK-AREGRTCIVIAH--RLS 1235
Query: 249 IFKLFDSLTLLASGRLMFHGPAQEAL 274
+ D + + +GR+ HG Q+ L
Sbjct: 1236 TIQNADLIVVFQNGRVKEHGTHQQLL 1261
Score = 61.6 bits (148), Expect = 2e-09
Identities = 61/197 (30%), Positives = 103/197 (52%), Gaps = 16/197 (8%)
Query: 54 PCRKPVEKEILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP 112
P RK V+ IL +N ++ G A++G +G GKS+ + ++ DP+ G V ++G
Sbjct: 402 PSRKEVK--ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPT--EGMVSVDGQD 457
Query: 113 -RPANFKCNS---GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN-ERINRVIQE 167
R N + G V Q+ V+ T T+ EN+++ R TM EK + N
Sbjct: 458 IRTINVRFLREIIGVVSQEPVLFAT-TIAENIRYG---RENVTMDEIEKAVKEANAYDFI 513
Query: 168 LGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLL 227
+ L D+ VG + + +SGG+++R +I L+ +P IL LDE T+ LD+ + V +
Sbjct: 514 MKLPHKFDTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 228 LKRMSKQGRTIIFSIHQ 244
L + +++GRT I H+
Sbjct: 573 LDK-ARKGRTTIVIAHR 588
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 68.2 bits (165), Expect = 2e-11
Identities = 59/204 (28%), Positives = 107/204 (52%), Gaps = 15/204 (7%)
Query: 77 AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAP-RPAN---FKCNSGYVVQDDVVMG 132
A++G +G GKS+++ +L DP L+G VL++G + N + G V Q+ ++
Sbjct: 1019 ALVGSSGCGKSTVVQLLERFYDP--LAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1076
Query: 133 TLTVRENLQFSAALRLATT--MTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGE 190
++ EN+ + R+ + + + K I+ I+ L +++VG + + +SGG+
Sbjct: 1077 C-SIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL--PHKYETRVGDKGTQ-LSGGQ 1132
Query: 191 RKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIF 250
++R +I LI P IL LDE T+ LD+ + V L + +++GRT I H R S
Sbjct: 1133 KQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK-AREGRTCIVIAH--RLSTI 1189
Query: 251 KLFDSLTLLASGRLMFHGPAQEAL 274
+ D + + +GR+ HG Q+ L
Sbjct: 1190 QNADLIVVFQNGRVKEHGTHQQLL 1213
Score = 58.9 bits (141), Expect = 1e-08
Identities = 63/220 (28%), Positives = 107/220 (48%), Gaps = 18/220 (8%)
Query: 62 EILSNINGIMKPGLN-AILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN 120
+IL +N ++ G A++G +G GKS+ + ++ DP G + I+G NF N
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD--EGTINIDGQDI-RNFNVN 466
Query: 121 S-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKN-ERINRVIQELGLDKVA 174
G V Q+ V+ T T+ EN+ + R TM +K + N + L +
Sbjct: 467 YLREIIGVVSQEPVLFST-TIAENICYG---RGNVTMDEIKKAVKEANAYEFIMKLPQKF 522
Query: 175 DSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQ 234
D+ VG + + +SGG+++R +I L+ +P IL LDE T+ LD+ + V L + +++
Sbjct: 523 DTLVGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDK-ARE 580
Query: 235 GRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEAL 274
GRT I H R S + D + G ++ G E +
Sbjct: 581 GRTTIVIAH--RLSTVRNADVIAGFEDGVIVEQGSHSELM 618
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,656,984
Number of Sequences: 37866
Number of extensions: 978979
Number of successful extensions: 2446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2153
Number of HSP's gapped (non-prelim): 161
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.