BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] (652 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] 1371 0.0 gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] 1338 0.0 gi|62388879 carboxypeptidase Z isoform 3 [Homo sapiens] 1082 0.0 gi|4503009 carboxypeptidase E preproprotein [Homo sapiens] 403 e-112 gi|9994201 carboxypeptidase X, member 1 precursor [Homo sapiens] 394 e-109 gi|4503011 carboxypeptidase N, polypeptide 1 precursor [Homo sap... 387 e-107 gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sap... 368 e-102 gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 342 6e-94 gi|22202611 carboxypeptidase D precursor [Homo sapiens] 320 3e-87 gi|53832021 carboxypeptidase M precursor [Homo sapiens] 266 3e-71 gi|38327526 carboxypeptidase M precursor [Homo sapiens] 266 3e-71 gi|6631081 carboxypeptidase M precursor [Homo sapiens] 266 3e-71 gi|4503827 frizzled 2 [Homo sapiens] 70 6e-12 gi|8393378 frizzled 3 [Homo sapiens] 68 2e-11 gi|4503833 frizzled 7 [Homo sapiens] 67 4e-11 gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] 66 1e-10 gi|6005762 frizzled 10 [Homo sapiens] 65 2e-10 gi|27894385 frizzled 5 precursor [Homo sapiens] 65 3e-10 gi|4503825 frizzled 1 [Homo sapiens] 64 3e-10 gi|34734079 frizzled 6 [Homo sapiens] 64 4e-10 gi|4503835 frizzled 9 [Homo sapiens] 64 4e-10 gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] 64 6e-10 gi|29244926 corin [Homo sapiens] 64 6e-10 gi|38455388 frizzled-related protein [Homo sapiens] 63 7e-10 gi|48475052 secreted frizzled-related protein 2 precursor [Homo ... 61 4e-09 gi|13994190 frizzled 8 [Homo sapiens] 61 4e-09 gi|13899255 membrane frizzled-related protein [Homo sapiens] 60 6e-09 gi|61743916 carboxypeptidase A4 preproprotein [Homo sapiens] 60 6e-09 gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] 56 9e-08 gi|22547161 frizzled 4 [Homo sapiens] 53 8e-07 >gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] Length = 652 Score = 1371 bits (3549), Expect = 0.0 Identities = 652/652 (100%), Positives = 652/652 (100%) Query: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT 60 MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT Sbjct: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT 60 Query: 61 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH 120 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH Sbjct: 61 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH 120 Query: 121 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP 180 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP Sbjct: 121 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP 180 Query: 181 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE 240 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE Sbjct: 181 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE 240 Query: 241 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA 300 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA Sbjct: 241 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA 300 Query: 301 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE 360 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE Sbjct: 301 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE 360 Query: 361 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD 420 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD Sbjct: 361 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD 420 Query: 421 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP 480 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP Sbjct: 421 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP 480 Query: 481 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY 540 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY Sbjct: 481 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY 540 Query: 541 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP 600 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP Sbjct: 541 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP 600 Query: 601 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 652 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY Sbjct: 601 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 652 >gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] Length = 641 Score = 1338 bits (3462), Expect = 0.0 Identities = 641/652 (98%), Positives = 641/652 (98%), Gaps = 11/652 (1%) Query: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT 60 MPPPPPLLLLTVLVVAAARPGCEFERNPA ATCVDLQLRTCSDAAYNHTT Sbjct: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPA-----------ATCVDLQLRTCSDAAYNHTT 49 Query: 61 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH 120 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH Sbjct: 50 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH 109 Query: 121 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP 180 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP Sbjct: 110 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP 169 Query: 181 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE 240 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE Sbjct: 170 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE 229 Query: 241 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA 300 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA Sbjct: 230 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA 289 Query: 301 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE 360 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE Sbjct: 290 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE 349 Query: 361 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD 420 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD Sbjct: 350 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD 409 Query: 421 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP 480 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP Sbjct: 410 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP 469 Query: 481 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY 540 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY Sbjct: 470 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY 529 Query: 541 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP 600 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP Sbjct: 530 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP 589 Query: 601 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 652 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY Sbjct: 590 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 641 >gi|62388879 carboxypeptidase Z isoform 3 [Homo sapiens] Length = 515 Score = 1082 bits (2797), Expect = 0.0 Identities = 515/515 (100%), Positives = 515/515 (100%) Query: 138 MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL 197 MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL Sbjct: 1 MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL 60 Query: 198 RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM 257 RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM Sbjct: 61 RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM 120 Query: 258 LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ 317 LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ Sbjct: 121 LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ 180 Query: 318 NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA 377 NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA Sbjct: 181 NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA 240 Query: 378 SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF 437 SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF Sbjct: 241 SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF 300 Query: 438 LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLN 497 LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLN Sbjct: 301 LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLN 360 Query: 498 FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG 557 FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG Sbjct: 361 FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG 420 Query: 558 YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD 617 YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD Sbjct: 421 YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD 480 Query: 618 PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 652 PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY Sbjct: 481 PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 515 >gi|4503009 carboxypeptidase E preproprotein [Homo sapiens] Length = 476 Score = 403 bits (1036), Expect = e-112 Identities = 205/409 (50%), Positives = 271/409 (66%), Gaps = 16/409 (3%) Query: 183 IRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVK 242 I F +H Y ++ L +C ++R Y++GRSF+GRELLVIE S PG HE EPE K Sbjct: 49 ISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFK 108 Query: 243 LIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAE 302 IGN+HGNE GRE+LI+LAQYLC+EY GN I L+++TRIH++PS+NPDG+E AA++ Sbjct: 109 YIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQ 168 Query: 303 GAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI------PIPQHYWWGK 356 W GR NAQ +DLNRNFPDL Y + E G ++H+ + Q+ K Sbjct: 169 PGELKDWFVGRSNAQGIDLNRNFPDLDRIVY-VNEKEGGPNNHLLKNMKKIVDQN---TK 224 Query: 357 VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSR 416 +APETKA++ W+ IPFVLSA+LHGGDLV +YP+D ++ + +S +PD+ +F+ L+R Sbjct: 225 LAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHE-YSSSPDDAIFQSLAR 283 Query: 417 AYADVHPMMMDRSENRCGGNFLKRGSI---INGADWYSFTGGMSDFNYLHTNCFEITVEL 473 AY+ +P M D + C N + NG WYS GGM DFNYL +NCFEITVEL Sbjct: 284 AYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVEL 343 Query: 474 GCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDIT 533 C KFPPEE L T W+ NK SL++++E +HRG+KG V D G P+ NA ISV+GI HD+T Sbjct: 344 SCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVT 403 Query: 534 TAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQ 582 +A DGDYWRLL PG + + A APGY + KKV +P A VDF L+ Sbjct: 404 SAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVP--YSPAAGVDFELE 450 >gi|9994201 carboxypeptidase X, member 1 precursor [Homo sapiens] Length = 734 Score = 394 bits (1011), Expect = e-109 Identities = 194/388 (50%), Positives = 264/388 (68%), Gaps = 10/388 (2%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F HH+Y M +++++ +C ++ R YSIG+S+ G +L V+E S +PG+HEL EPEV+ + Sbjct: 297 FQHHNYKAMRKLMKQVQEQCPNITRIYSIGKSYQGLKLYVMEMSDKPGEHELGEPEVRYV 356 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 +HGNE GRE+L+ L Q+LC E+L GNPR+ RLL+ RIHLLPSMNPDGYE+A G+ Sbjct: 357 AGMHGNEALGRELLLLLMQFLCHEFLRGNPRVTRLLSEMRIHLLPSMNPDGYEIAYHRGS 416 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRG-----ARSDHIPIPQHYWW--GKV 357 GW GR N Q++DLN NF DL + + A+ G + H+P+P +Y V Sbjct: 417 ELVGWAEGRWNNQSIDLNHNFADLNTPLWE-AQDDGKVPHIVPNHHLPLPTYYTLPNATV 475 Query: 358 APETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRA 417 APET+A++KWM+ IPFVLSA+LHGG+LVVSYPFD ++ P + +PTPD+ +F+ LS Sbjct: 476 APETRAVIKWMKRIPFVLSANLHGGELVVSYPFDMTRTPWAARELTPTPDDAVFRWLSTV 535 Query: 418 YADVHPMMMDRSENRC-GGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCV 476 YA + M D S C +F G+IINGADW++ G M+DF+YLHTNCFE+TVEL C Sbjct: 536 YAGSNLAMQDTSRRPCHSQDFSVHGNIINGADWHTVPGSMNDFSYLHTNCFEVTVELSCD 595 Query: 477 KFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGK-PVKNARISVKGIRHDITTA 535 KFP E L W++NK++LL ++E V GI GVV DK + + +A I+V GI HD+TTA Sbjct: 596 KFPHENELPQEWENNKDALLTYLEQVRMGIAGVVRDKDTELGIADAVIAVDGINHDVTTA 655 Query: 536 PDGDYWRLLPPGIHIVIAQAPGYAKVIK 563 GDYWRLL PG ++V A A GY V + Sbjct: 656 WGGDYWRLLTPGDYMVTASAEGYHSVTR 683 >gi|4503011 carboxypeptidase N, polypeptide 1 precursor [Homo sapiens] Length = 458 Score = 387 bits (993), Expect = e-107 Identities = 193/380 (50%), Positives = 253/380 (66%), Gaps = 10/380 (2%) Query: 183 IRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVK 242 + F HH Y +VR L + + C + R YSIGRS +GR L V+EFS PG HE +EPEVK Sbjct: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80 Query: 243 LIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAE 302 +GN+HGNE GRE+++ L+++LC E+ N RI +L+ TRIH+LPSMNPDGYEVAAA+ Sbjct: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140 Query: 303 GAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETK 362 G G+ GR NA +DLNRNFPDL + Y E G + H+P+P + W +V PET+ Sbjct: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNT-YIYYNEKYGGPNHHLPLPDN-WKSQVEPETR 198 Query: 363 AIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ----EEKMFSPTPDEKMFKLLSRAY 418 A+++WM + FVLSA+LHGG +V +YP+D S + +PTPD+K+F+ L++ Y Sbjct: 199 AVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 Query: 419 ADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKF 478 + H M CG F I NGA WYS + GM DFNYLHTNCFEIT+EL C KF Sbjct: 259 SYAHGWMFQGW--NCGDYF--PDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKF 314 Query: 479 PPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDG 538 PPEE L W N+E+L+ F+E VH+GIKG+V D+ + NA ISV GI HD+T+ G Sbjct: 315 PPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHG 374 Query: 539 DYWRLLPPGIHIVIAQAPGY 558 DY+RLL PGI+ V A APGY Sbjct: 375 DYFRLLLPGIYTVSATAPGY 394 >gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sapiens] Length = 756 Score = 368 bits (945), Expect = e-102 Identities = 185/414 (44%), Positives = 260/414 (62%), Gaps = 18/414 (4%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F HH+Y +M ++++ C ++ R Y+IG+S G +L +E S PG+HE+ EPE I Sbjct: 316 FKHHNYKEMRQLMKVVNEMCPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYI 375 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 HGNEV GRE+L+ L Q++C EYL N RI L+ TRIH+LPS+NPDGYE A G+ Sbjct: 376 AGAHGNEVLGRELLLLLVQFVCQEYLARNARIVHLVEETRIHVLPSLNPDGYEKAYEGGS 435 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIP--IPQHY-----WW--- 354 GW+ GR +D+N NFPDL + + AE R ++P +P HY W+ Sbjct: 436 ELGGWSLGRWTHDGIDINNNFPDLNTLLWE-AEDR----QNVPRKVPNHYIAIPEWFLSE 490 Query: 355 -GKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKL 413 VA ET+A++ WM+ IPFVL +L GG+LVV+YP+D + P + + +PTPD+ +F+ Sbjct: 491 NATVAAETRAVIAWMEKIPFVLGGNLQGGELVVAYPYDLVRSPWKTQEHTPTPDDHVFRW 550 Query: 414 LSRAYADVHPMMMDRSENRCGG-NFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVE 472 L+ +YA H +M D C +F K +NGA W++ G ++DF+YLHTNCFE+++ Sbjct: 551 LAYSYASTHRLMTDARRRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYLHTNCFELSIY 610 Query: 473 LGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDI 532 +GC K+P E L W++N+ESL+ F+E VHRGIKG+V D GK + NA ISV+GI HDI Sbjct: 611 VGCDKYPHESQLPEEWENNRESLIVFMEQVHRGIKGLVRDSHGKGIPNAIISVEGINHDI 670 Query: 533 TTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGM 586 TA DGDYWRLL PG ++V A+A G+ K ++ M A R DF L M Sbjct: 671 RTANDGDYWRLLNPGEYVVTAKAEGFTASTKNCMVGYDM-GATRCDFTLSKTNM 723 >gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo sapiens] Length = 1158 Score = 342 bits (877), Expect = 6e-94 Identities = 175/404 (43%), Positives = 243/404 (60%), Gaps = 25/404 (6%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F HHSY M ++++ C + RTYS+G+S G ++ +E S PG+HEL EPE + Sbjct: 562 FRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYT 621 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 IHGNEV GRE+L+ L QYLC EY GNPR++ L+ TRIHL+PS+NPDGYEVAA G+ Sbjct: 622 AGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGS 681 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETR----GARSDHIPIPQHYWW--GKVA 358 + W G + D+ +FPDL S + E + ++++PIP+ Y V+ Sbjct: 682 EFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVS 741 Query: 359 PETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFS--------------- 403 E +AI+ WM+ PFVL A+L+GG+ +VSYP+D ++ P +E++ + Sbjct: 742 TEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVS 801 Query: 404 ---PTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRG-SIINGADWYSFTGGMSDF 459 TPD +F+ L+ ++A H + + C G I+NGA W TG ++DF Sbjct: 802 EAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDF 861 Query: 460 NYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVK 519 +YLHTNC E++ LGC KFP E L W++NKE+LL F+E VHRGIKGVVTD+ G P+ Sbjct: 862 SYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIA 921 Query: 520 NARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIK 563 NA ISV GI H + TA GDYWR+L PG + V A A GY K Sbjct: 922 NATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAK 965 >gi|22202611 carboxypeptidase D precursor [Homo sapiens] Length = 1380 Score = 320 bits (820), Expect = 3e-87 Identities = 175/400 (43%), Positives = 243/400 (60%), Gaps = 33/400 (8%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F HH + M LRR A+ ++ R YS+G+S + REL V+E S PG HE EPE K I Sbjct: 501 FHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYI 560 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 GN+HGNEV GRE+L+ L +YLC + +P + L++ TRIHL+PSMNPDGYE + EG Sbjct: 561 GNMHGNEVVGRELLLNLIEYLCKNFGT-DPEVTDLVHNTRIHLMPSMNPDGYE-KSQEGD 618 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 364 + GR N+ N DLNRNFPD ++ ++ + PET A+ Sbjct: 619 SIS--VIGRNNSNNFDLNRNFPD---QFVQITDP------------------TQPETIAV 655 Query: 365 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPM 424 M WM++ PFVLSA+LHGG LVV+YPFD + Q +S +PD+ +F+ ++ +Y+ + Sbjct: 656 MSWMKSYPFVLSANLHGGSLVVNYPFDDDE--QGLATYSKSPDDAVFQQIALSYSKENSQ 713 Query: 425 MMDRS--ENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEE 482 M +N + G I NGA WY+ GGM D+NYL TNCFE+T+ELGCVK+P E+ Sbjct: 714 MFQGRPCKNMYPNEYFPHG-ITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEK 772 Query: 483 ALYTLWQHNKESLLNFVETVHRGIKGVVTDKF-GKPVKNARISVKGIRHDITTAPDGDYW 541 L W+ N+ SL+ F++ VH+G++G V D G+ + NA ISV I H +TT GDYW Sbjct: 773 ELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYW 832 Query: 542 RLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFIL 581 RLL PG + + A A GY V K V + + + A +V+F L Sbjct: 833 RLLVPGTYKITASARGYNPVTKNVTV--KSEGAIQVNFTL 870 Score = 280 bits (717), Expect = 2e-75 Identities = 170/431 (39%), Positives = 241/431 (55%), Gaps = 53/431 (12%) Query: 182 FIRFSHHSYAQMVRVLRRTASR-CAHVARTYSIGRSFDGRELLVIEFSSRPGQ------- 233 F R+ H ++ LR A+ +AR +SIGRS +GR L V+ ++ G Sbjct: 55 FDRYYHEE--ELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDA 112 Query: 234 ----------HELM--EPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLN 281 L+ P+VKL+GN+HG+E R++LIYLA+ L + Y G+PR+ RLLN Sbjct: 113 GPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLN 172 Query: 282 TTRIHLLPSMNPDGYEVAAAEGAGYN----GWTSGRQNAQNLDLNRNFPDL--TSEYYRL 335 TT ++LLPS+NPDG+E A G+ SGR N++ DLNR+FPD T E L Sbjct: 173 TTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPAL 232 Query: 336 AETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKH 395 E PE +A+++W++ FVLS +LHGG +V SYPFD S Sbjct: 233 DEV--------------------PEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPE 272 Query: 396 PQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLK--RGSIINGADWYSFT 453 + ++S T D+++FK L++AYA HP+M E C G+ + + I NGA WY Sbjct: 273 HKATGIYSKTSDDEVFKYLAKAYASNHPIMKT-GEPHCPGDEDETFKDGITNGAHWYDVE 331 Query: 454 GGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDK 513 GGM D+NY+ NCFEIT+EL C K+PP L W++N+ESL+ +E VH G+KG V D Sbjct: 332 GGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDS 391 Query: 514 F-GKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMK 572 G ++NA ISV GI H+ITT GD++RLL PG + + GY + ++ + Sbjct: 392 ITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVV-VKEG 450 Query: 573 RAGRVDFILQP 583 A VDF L+P Sbjct: 451 PATEVDFSLRP 461 Score = 197 bits (502), Expect = 2e-50 Identities = 135/423 (31%), Positives = 209/423 (49%), Gaps = 57/423 (13%) Query: 159 DPLEKLRGGLEADEALPSGLPPTFIRFS---------HHSYAQMVRVLRRTASRCAHVAR 209 DP K L D + +GL +R S +HSY + LR H+ Sbjct: 896 DPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITN 955 Query: 210 TYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEY 269 ++G+S + R + +E S++P E EP+++ + IHGN G E+L+ LA++LC Y Sbjct: 956 LTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNY 1015 Query: 270 LLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLT 329 NP + +L++ TRI ++PS+NPDG E A + G+ NA+ DL+ +F + Sbjct: 1016 KK-NPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSK---IGQTNARGKDLDTDFTNNA 1071 Query: 330 SEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMK-WMQTIPFVLSASLHGGDLVVSY 388 S+ PETKAI++ +Q F LS +L GG ++V+Y Sbjct: 1072 SQ---------------------------PETKAIIENLIQKQDFSLSVALDGGSMLVTY 1104 Query: 389 PFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMM---MDRSENRCGGNFLKRGSIIN 445 P+D K +++ K L+ YA+ HP M N+ N G ++ Sbjct: 1105 PYD--------KPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENI--PGGVMR 1154 Query: 446 GADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRG 505 GA+W+S G M D++ + +C EITV C FP L +LW NK SLL+ + VH+G Sbjct: 1155 GAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKG 1214 Query: 506 IKGVVTDKFGKPVKNARISV-KGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKK 564 + G V DK GKP+ A I + +GI+ + T G + LL PG+H +IA A GY + + Sbjct: 1215 VHGFVKDKTGKPISKAVIVLNEGIK--VQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQ 1272 Query: 565 VII 567 V + Sbjct: 1273 VFV 1275 >gi|53832021 carboxypeptidase M precursor [Homo sapiens] Length = 443 Score = 266 bits (681), Expect = 3e-71 Identities = 153/389 (39%), Positives = 212/389 (54%), Gaps = 30/389 (7%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F++H M L+ A + V +SIG+S GR L V+ P +H + PE K + Sbjct: 20 FNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYV 79 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 N+HG+E GRE+L++L YL + +P I L+N+TRIH++PSMNPDG+E Sbjct: 80 ANMHGDETVGRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDC 138 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 364 Y+ GR+N DLNRNFPD EY ++ PET A+ Sbjct: 139 YYS---IGRENYNQYDLNRNFPD-AFEYNNVSRQ--------------------PETVAV 174 Query: 365 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMF-SPTPDEKMFKLLSRAYADVHP 423 MKW++T FVLSA+LHGG LV SYPFD S TPD+ +F+ L+ YA +P Sbjct: 175 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNP 234 Query: 424 MMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEA 483 M E + NF + NG WY GGM D+NY+ CFEIT+EL C K+P EE Sbjct: 235 NMKKGDECKNKMNF--PNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEK 292 Query: 484 LYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRH--DITTAPDGDYW 541 L + W +NK SL+ +++ VH G+KG V D+ G P+ N + V+ +H T G+Y+ Sbjct: 293 LPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYY 352 Query: 542 RLLPPGIHIVIAQAPGYAKVIKKVIIPAR 570 LL PG +I+ PG+ I KVIIP + Sbjct: 353 LLLLPGSYIINVTVPGHDPHITKVIIPEK 381 >gi|38327526 carboxypeptidase M precursor [Homo sapiens] Length = 443 Score = 266 bits (681), Expect = 3e-71 Identities = 153/389 (39%), Positives = 212/389 (54%), Gaps = 30/389 (7%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F++H M L+ A + V +SIG+S GR L V+ P +H + PE K + Sbjct: 20 FNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYV 79 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 N+HG+E GRE+L++L YL + +P I L+N+TRIH++PSMNPDG+E Sbjct: 80 ANMHGDETVGRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDC 138 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 364 Y+ GR+N DLNRNFPD EY ++ PET A+ Sbjct: 139 YYS---IGRENYNQYDLNRNFPD-AFEYNNVSRQ--------------------PETVAV 174 Query: 365 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMF-SPTPDEKMFKLLSRAYADVHP 423 MKW++T FVLSA+LHGG LV SYPFD S TPD+ +F+ L+ YA +P Sbjct: 175 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNP 234 Query: 424 MMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEA 483 M E + NF + NG WY GGM D+NY+ CFEIT+EL C K+P EE Sbjct: 235 NMKKGDECKNKMNF--PNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEK 292 Query: 484 LYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRH--DITTAPDGDYW 541 L + W +NK SL+ +++ VH G+KG V D+ G P+ N + V+ +H T G+Y+ Sbjct: 293 LPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYY 352 Query: 542 RLLPPGIHIVIAQAPGYAKVIKKVIIPAR 570 LL PG +I+ PG+ I KVIIP + Sbjct: 353 LLLLPGSYIINVTVPGHDPHITKVIIPEK 381 >gi|6631081 carboxypeptidase M precursor [Homo sapiens] Length = 443 Score = 266 bits (681), Expect = 3e-71 Identities = 153/389 (39%), Positives = 212/389 (54%), Gaps = 30/389 (7%) Query: 185 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 244 F++H M L+ A + V +SIG+S GR L V+ P +H + PE K + Sbjct: 20 FNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYV 79 Query: 245 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 304 N+HG+E GRE+L++L YL + +P I L+N+TRIH++PSMNPDG+E Sbjct: 80 ANMHGDETVGRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDC 138 Query: 305 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 364 Y+ GR+N DLNRNFPD EY ++ PET A+ Sbjct: 139 YYS---IGRENYNQYDLNRNFPD-AFEYNNVSRQ--------------------PETVAV 174 Query: 365 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMF-SPTPDEKMFKLLSRAYADVHP 423 MKW++T FVLSA+LHGG LV SYPFD S TPD+ +F+ L+ YA +P Sbjct: 175 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNP 234 Query: 424 MMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEA 483 M E + NF + NG WY GGM D+NY+ CFEIT+EL C K+P EE Sbjct: 235 NMKKGDECKNKMNF--PNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEK 292 Query: 484 LYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRH--DITTAPDGDYW 541 L + W +NK SL+ +++ VH G+KG V D+ G P+ N + V+ +H T G+Y+ Sbjct: 293 LPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYY 352 Query: 542 RLLPPGIHIVIAQAPGYAKVIKKVIIPAR 570 LL PG +I+ PG+ I KVIIP + Sbjct: 353 LLLLPGSYIINVTVPGHDPHITKVIIPEK 381 >gi|4503827 frizzled 2 [Homo sapiens] Length = 565 Score = 70.1 bits (170), Expect = 6e-12 Identities = 47/145 (32%), Positives = 68/145 (46%), Gaps = 12/145 (8%) Query: 6 PLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLL 65 P LLL +L++ AA P +F D C + + C+D AYN T PNLL Sbjct: 8 PRLLLPLLLLPAAGPA-QFHGEKGISI-----PDHGFCQPISIPLCTDIAYNQTIMPNLL 61 Query: 66 QHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG-GWVRRPCRHICEG 124 H + E +A E + + L++ QC+P+LR C++ AP C PCR ICE Sbjct: 62 GHTNQE--DAGLE---VHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICER 116 Query: 125 LREVCQPAFDAIDMAWPYFLDCHRY 149 R+ C+ + WP L C + Sbjct: 117 ARQGCEALMNKFGFQWPERLRCEHF 141 >gi|8393378 frizzled 3 [Homo sapiens] Length = 666 Score = 68.2 bits (165), Expect = 2e-11 Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 11/124 (8%) Query: 42 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 101 +C + LR C D YN T PNLL H + + + + H ++ C+ D R Sbjct: 27 SCEPITLRMCQDLPYNTTFMPNLLNH-----YDQQTAALAMEPFHPMVNLDCSRDFRPFL 81 Query: 102 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 160 CA+ AP C E G V PCR +C+ C + + WP ++C R+ C +P Sbjct: 82 CALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRF-----PDCDEP 136 Query: 161 LEKL 164 +L Sbjct: 137 YPRL 140 >gi|4503833 frizzled 7 [Homo sapiens] Length = 574 Score = 67.4 bits (163), Expect = 4e-11 Identities = 37/112 (33%), Positives = 55/112 (49%), Gaps = 6/112 (5%) Query: 39 DSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLR 98 D C + + C+D AYN T PNLL H + E +A E + + L++ QC+P+LR Sbjct: 45 DHGFCQPISIPLCTDIAYNQTILPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSPELR 99 Query: 99 LLGCAVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149 C++ AP C PCR +CE R+ C+ + WP L C + Sbjct: 100 FFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENF 151 >gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] Length = 317 Score = 65.9 bits (159), Expect = 1e-10 Identities = 36/110 (32%), Positives = 55/110 (50%), Gaps = 10/110 (9%) Query: 43 CVDL--QLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRL 99 C+D+ L C Y PNLL+H S EV + +S ++ LL +C+ D ++ Sbjct: 53 CLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWL------PLLAKRCHSDTQV 106 Query: 100 LGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149 C++ AP C + PCR +CE +R C P +A WP L CH++ Sbjct: 107 FLCSLFAPVCLDRPIY-PCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKF 155 >gi|6005762 frizzled 10 [Homo sapiens] Length = 581 Score = 65.5 bits (158), Expect = 2e-10 Identities = 56/191 (29%), Positives = 77/191 (40%), Gaps = 21/191 (10%) Query: 2 PPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTF 61 P P L+L V+ AA + ER G+C +++ C D YN T Sbjct: 4 PGPRLWLVLQVMGSCAAISSMDMERPGDGKCQ-----------PIEIPMCKDIGYNMTRM 52 Query: 62 PNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRP---C 118 PNL+ H + EA+ I L L+E C+ LR C++ AP C V P C Sbjct: 53 PNLMGHENQR--EAA---IQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQ-VSTPIPAC 106 Query: 119 RHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGL 178 R +CE R C P + + WP LDC + + D Y +E G + Sbjct: 107 RVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPN-YLCMEAPNNGSDEPTRGSGLF 165 Query: 179 PPTFIRFSHHS 189 PP F HS Sbjct: 166 PPLFRPQRPHS 176 >gi|27894385 frizzled 5 precursor [Homo sapiens] Length = 585 Score = 64.7 bits (156), Expect = 3e-10 Identities = 45/152 (29%), Positives = 63/152 (41%), Gaps = 27/152 (17%) Query: 2 PPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTF 61 P PP LLL +L R A+ + C ++ + C YN T Sbjct: 6 PSAPPSLLLLLLAQLVGRAAA--------------ASKAPVCQEITVPMCRGIGYNLTHM 51 Query: 62 PNLLQHRSWEVVEASSEYILLSVLHQ---LLEGQCNPDLRLLGCAVLAPRCEGGWVRR-- 116 PN H + + EA E +HQ L+E QC+PDLR C++ P C + + Sbjct: 52 PNQFNHDTQD--EAGLE------VHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLP 103 Query: 117 PCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 148 PCR +CE + C P AWP + C R Sbjct: 104 PCRSVCERAKAGCSPLMRQYGFAWPERMSCDR 135 >gi|4503825 frizzled 1 [Homo sapiens] Length = 647 Score = 64.3 bits (155), Expect = 3e-10 Identities = 35/112 (31%), Positives = 55/112 (49%), Gaps = 6/112 (5%) Query: 39 DSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLR 98 D C + + C+D AYN T PNLL H + E +A E + + L++ QC+ +L+ Sbjct: 112 DHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSAELK 166 Query: 99 LLGCAVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149 C++ AP C PCR +CE R+ C+ + WP L C ++ Sbjct: 167 FFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKF 218 >gi|34734079 frizzled 6 [Homo sapiens] Length = 706 Score = 63.9 bits (154), Expect = 4e-10 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 6/108 (5%) Query: 42 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 101 TC + + C AYN T FPNL+ H + E+ L L +C+P++ Sbjct: 23 TCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL-----PLANLECSPNIETFL 77 Query: 102 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 148 C P C E V PCR +CE + C+ D + WP L+C R Sbjct: 78 CKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDR 125 >gi|4503835 frizzled 9 [Homo sapiens] Length = 591 Score = 63.9 bits (154), Expect = 4e-10 Identities = 42/118 (35%), Positives = 57/118 (48%), Gaps = 9/118 (7%) Query: 40 SATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRL 99 +A C +++ C YN T PNLL H S EA++E L+ L++ C+ LR Sbjct: 36 AAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQG--EAAAE---LAEFAPLVQYGCHSHLRF 90 Query: 100 LGCAVLAPRCEGGWVRRP---CRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTRED 154 C++ AP C V P CR +CE R C P + + WP LDC R TR D Sbjct: 91 FLCSLYAPMCTDQ-VSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRND 147 >gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] Length = 314 Score = 63.5 bits (153), Expect = 6e-10 Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 10/110 (9%) Query: 43 CVDL--QLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRL 99 CVD+ LR C + Y PNLL+H + EV + +S ++ LL C+ ++ Sbjct: 58 CVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWV------PLLNKNCHAGTQV 111 Query: 100 LGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149 C++ AP C + PCR +CE +R+ C+P WP L C ++ Sbjct: 112 FLCSLFAPVCLDRPIY-PCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKF 160 >gi|29244926 corin [Homo sapiens] Length = 1042 Score = 63.5 bits (153), Expect = 6e-10 Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 5/109 (4%) Query: 43 CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 102 C + L C + YN T++PN HR+ + S E S+ L++ C L C Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWES---SLFPALVQTNCYKYLMFFSC 511 Query: 103 AVLAPRCE--GGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 149 +L P+C+ G PCR +CE +E C+ + + WP DC ++ Sbjct: 512 TILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQF 560 Score = 53.1 bits (126), Expect = 8e-07 Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 19/145 (13%) Query: 28 PAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQ 87 P + HR +++ C+++ C Y+ T P L R+ E+ + + + LH+ Sbjct: 128 PGDQSHR----NTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFF---TYLHR 180 Query: 88 LLEGQCNPDLRLLGCAVLAPRC----EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYF 143 L C + L GC + P C + PCR CE +E C+ ++ +WP F Sbjct: 181 L---SCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDF 237 Query: 144 LDCHRYFTREDEG-----CYDPLEK 163 L C ++ + + C+ P ++ Sbjct: 238 LRCSQFRNQTESSNVSRICFSPQQE 262 >gi|38455388 frizzled-related protein [Homo sapiens] Length = 325 Score = 63.2 bits (152), Expect = 7e-10 Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 8/130 (6%) Query: 34 RPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQC 93 R P A +A C +++ C +N T PN L H + ++ + + LL C Sbjct: 26 RVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHST-----QANAILAIEQFEGLLGTHC 80 Query: 94 NPDLRLLGCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYF 150 +PDL CA+ AP C + +PC+ +CE R+ C+P +WP L C Sbjct: 81 SPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140 Query: 151 TREDEGCYDP 160 + C P Sbjct: 141 VYDRGVCISP 150 >gi|48475052 secreted frizzled-related protein 2 precursor [Homo sapiens] Length = 295 Score = 60.8 bits (146), Expect = 4e-09 Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 11/135 (8%) Query: 44 VDLQLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 102 + L+ C Y + PNLL H + EV+E + +I L+ QC+PD + C Sbjct: 43 IPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWI------PLVMKQCHPDTKKFLC 96 Query: 103 AVLAPRC--EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 160 ++ AP C + +PC +C +++ C P A WP L+C R F ++++ C P Sbjct: 97 SLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDR-FPQDNDLCI-P 154 Query: 161 LEKLRGGLEADEALP 175 L L A E P Sbjct: 155 LASSDHLLPATEEAP 169 >gi|13994190 frizzled 8 [Homo sapiens] Length = 694 Score = 60.8 bits (146), Expect = 4e-09 Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 13/117 (11%) Query: 37 AADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQ---LLEGQC 93 +A C ++ + C YN+T PN H + + EA E +HQ L+E QC Sbjct: 29 SAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQD--EAGLE------VHQFWPLVEIQC 80 Query: 94 NPDLRLLGCAVLAPRCEGGWVRR--PCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 148 +PDL+ C++ P C + + PCR +CE + C P AWP + C R Sbjct: 81 SPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDR 137 >gi|13899255 membrane frizzled-related protein [Homo sapiens] Length = 579 Score = 60.1 bits (144), Expect = 6e-09 Identities = 45/138 (32%), Positives = 58/138 (42%), Gaps = 15/138 (10%) Query: 27 NPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLL--QHRSWEVVEASSEYILLSV 84 N +G PP C +Q+ C +YN T FPN+ EVVE S Y L+ Sbjct: 453 NCSGPLFPPP---ELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTS 509 Query: 85 LHQLLEGQCNPDLRLLGCAVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYF 143 L C R L C +L PRC G V PCR +C+ CQ + WP+ Sbjct: 510 L------PCYQHFRRLLCGLLVPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPF- 562 Query: 144 LDCHRYFTRED-EGCYDP 160 +C+R D E C P Sbjct: 563 -NCNRLPEAADLEACAQP 579 >gi|61743916 carboxypeptidase A4 preproprotein [Homo sapiens] Length = 421 Score = 60.1 bits (144), Expect = 6e-09 Identities = 61/241 (25%), Positives = 102/241 (42%), Gaps = 22/241 (9%) Query: 186 SHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIG 245 ++HS + + A+ +AR IG SF+ R + V++FS+ G + P V L Sbjct: 122 AYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKG---VRRPAVWLNA 178 Query: 246 NIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAG 305 IH E + I+ A+ + S+Y +P I +L I LLP NPDGY + Sbjct: 179 GIHSREWISQATAIWTARKIVSDY-QRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRL 237 Query: 306 YNGWTSGRQNAQ--NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKA 363 + S + D NRN + +GA + H E K+ Sbjct: 238 WRKTRSRNPGSSCIGADPNRN-------WNASFAGKGASDNPCSEVYHGPHANSEVEVKS 290 Query: 364 IMKWMQTI-PFVLSASLHGGDLVVSYPFDFS--KHPQEEKMFSPTPDEKMFKLLSRAYAD 420 ++ ++Q F LH ++ YP+ +S K P E++ +K+ +L ++A A Sbjct: 291 VVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEEL------DKVARLAAKALAS 344 Query: 421 V 421 V Sbjct: 345 V 345 >gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] Length = 346 Score = 56.2 bits (134), Expect = 9e-08 Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 8/123 (6%) Query: 41 ATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLL 100 A C +++ C +N T PN L H + E + + + +L++ C+ LR Sbjct: 22 APCEAVRIPMCRHMPWNITRMPNHLHHSTQE-----NAILAIEQYEELVDVNCSAVLRFF 76 Query: 101 GCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGC 157 CA+ AP C ++ +PC+ +C+ R+ C+P + +WP L C + C Sbjct: 77 LCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVC 136 Query: 158 YDP 160 P Sbjct: 137 ISP 139 >gi|22547161 frizzled 4 [Homo sapiens] Length = 537 Score = 53.1 bits (126), Expect = 8e-07 Identities = 29/114 (25%), Positives = 52/114 (45%), Gaps = 7/114 (6%) Query: 43 CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 102 C +++ C + YN T PNL+ H ++ +E + L+ L++ C+ L+ C Sbjct: 45 CDPIRISMCQNLGYNVTKMPNLVGHE----LQTDAE-LQLTTFTPLIQYGCSSQLQFFLC 99 Query: 103 AVLAPRCEG--GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTRED 154 +V P C PC +C ++ C+P AWP L+C ++ + D Sbjct: 100 SVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQND 153 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.139 0.449 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,285,074 Number of Sequences: 37866 Number of extensions: 1455834 Number of successful extensions: 3389 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 32 Number of HSP's successfully gapped in prelim test: 19 Number of HSP's that attempted gapping in prelim test: 3254 Number of HSP's gapped (non-prelim): 61 length of query: 652 length of database: 18,247,518 effective HSP length: 109 effective length of query: 543 effective length of database: 14,120,124 effective search space: 7667227332 effective search space used: 7667227332 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.