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Search of human proteins with 62388875
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo
sapiens]
(641 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] 1346 0.0
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] 1338 0.0
gi|62388879 carboxypeptidase Z isoform 3 [Homo sapiens] 1082 0.0
gi|4503009 carboxypeptidase E preproprotein [Homo sapiens] 403 e-112
gi|9994201 carboxypeptidase X, member 1 precursor [Homo sapiens] 394 e-109
gi|4503011 carboxypeptidase N, polypeptide 1 precursor [Homo sap... 387 e-107
gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo sap... 368 e-102
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 342 6e-94
gi|22202611 carboxypeptidase D precursor [Homo sapiens] 320 3e-87
gi|53832021 carboxypeptidase M precursor [Homo sapiens] 266 3e-71
gi|38327526 carboxypeptidase M precursor [Homo sapiens] 266 3e-71
gi|6631081 carboxypeptidase M precursor [Homo sapiens] 266 3e-71
gi|4503827 frizzled 2 [Homo sapiens] 71 3e-12
gi|6005762 frizzled 10 [Homo sapiens] 70 6e-12
gi|27894385 frizzled 5 precursor [Homo sapiens] 68 2e-11
gi|8393378 frizzled 3 [Homo sapiens] 68 2e-11
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] 67 4e-11
gi|4503833 frizzled 7 [Homo sapiens] 66 9e-11
gi|4503835 frizzled 9 [Homo sapiens] 65 2e-10
gi|29244926 corin [Homo sapiens] 65 2e-10
gi|34734079 frizzled 6 [Homo sapiens] 64 4e-10
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] 64 6e-10
gi|4503825 frizzled 1 [Homo sapiens] 63 7e-10
gi|13994190 frizzled 8 [Homo sapiens] 61 3e-09
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ... 61 4e-09
gi|38455388 frizzled-related protein [Homo sapiens] 60 5e-09
gi|13899255 membrane frizzled-related protein [Homo sapiens] 60 5e-09
gi|61743916 carboxypeptidase A4 preproprotein [Homo sapiens] 60 6e-09
gi|22547161 frizzled 4 [Homo sapiens] 57 5e-08
gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] 56 9e-08
>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
Length = 641
Score = 1346 bits (3484), Expect = 0.0
Identities = 641/641 (100%), Positives = 641/641 (100%)
Query: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWE 60
MPPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWE
Sbjct: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWE 60
Query: 61 VVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQP 120
VVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQP
Sbjct: 61 VVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQP 120
Query: 121 AFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYA 180
AFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYA
Sbjct: 121 AFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYA 180
Query: 181 QMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNE 240
QMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNE
Sbjct: 181 QMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNE 240
Query: 241 VAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTS 300
VAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTS
Sbjct: 241 VAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTS 300
Query: 301 GRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTI 360
GRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTI
Sbjct: 301 GRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTI 360
Query: 361 PFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSEN 420
PFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSEN
Sbjct: 361 PFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSEN 420
Query: 421 RCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHN 480
RCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHN
Sbjct: 421 RCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHN 480
Query: 481 KESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIV 540
KESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIV
Sbjct: 481 KESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIV 540
Query: 541 IAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLG 600
IAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLG
Sbjct: 541 IAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLG 600
Query: 601 EATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 641
EATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
Sbjct: 601 EATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 641
>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
Length = 652
Score = 1338 bits (3462), Expect = 0.0
Identities = 641/652 (98%), Positives = 641/652 (98%), Gaps = 11/652 (1%)
Query: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPA-----------ATCVDLQLRTCSDAAYNHTT 49
MPPPPPLLLLTVLVVAAARPGCEFERNPA ATCVDLQLRTCSDAAYNHTT
Sbjct: 1 MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT 60
Query: 50 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH 109
FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH
Sbjct: 61 FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH 120
Query: 110 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP 169
ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP
Sbjct: 121 ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP 180
Query: 170 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE 229
TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE
Sbjct: 181 TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE 240
Query: 230 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA 289
VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA
Sbjct: 241 VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA 300
Query: 290 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE 349
AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE
Sbjct: 301 AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE 360
Query: 350 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD 409
TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD
Sbjct: 361 TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD 420
Query: 410 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP 469
VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP
Sbjct: 421 VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP 480
Query: 470 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY 529
EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY
Sbjct: 481 EEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY 540
Query: 530 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP 589
WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP
Sbjct: 541 WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP 600
Query: 590 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 641
HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
Sbjct: 601 HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 652
>gi|62388879 carboxypeptidase Z isoform 3 [Homo sapiens]
Length = 515
Score = 1082 bits (2797), Expect = 0.0
Identities = 515/515 (100%), Positives = 515/515 (100%)
Query: 127 MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL 186
MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL
Sbjct: 1 MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL 60
Query: 187 RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM 246
RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM
Sbjct: 61 RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM 120
Query: 247 LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ 306
LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ
Sbjct: 121 LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ 180
Query: 307 NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA 366
NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA
Sbjct: 181 NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA 240
Query: 367 SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF 426
SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF
Sbjct: 241 SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF 300
Query: 427 LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLN 486
LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLN
Sbjct: 301 LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLN 360
Query: 487 FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG 546
FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG
Sbjct: 361 FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG 420
Query: 547 YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD 606
YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD
Sbjct: 421 YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD 480
Query: 607 PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 641
PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
Sbjct: 481 PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY 515
>gi|4503009 carboxypeptidase E preproprotein [Homo sapiens]
Length = 476
Score = 403 bits (1036), Expect = e-112
Identities = 205/409 (50%), Positives = 271/409 (66%), Gaps = 16/409 (3%)
Query: 172 IRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVK 231
I F +H Y ++ L +C ++R Y++GRSF+GRELLVIE S PG HE EPE K
Sbjct: 49 ISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFK 108
Query: 232 LIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAE 291
IGN+HGNE GRE+LI+LAQYLC+EY GN I L+++TRIH++PS+NPDG+E AA++
Sbjct: 109 YIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQ 168
Query: 292 GAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI------PIPQHYWWGK 345
W GR NAQ +DLNRNFPDL Y + E G ++H+ + Q+ K
Sbjct: 169 PGELKDWFVGRSNAQGIDLNRNFPDLDRIVY-VNEKEGGPNNHLLKNMKKIVDQN---TK 224
Query: 346 VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSR 405
+APETKA++ W+ IPFVLSA+LHGGDLV +YP+D ++ + +S +PD+ +F+ L+R
Sbjct: 225 LAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHE-YSSSPDDAIFQSLAR 283
Query: 406 AYADVHPMMMDRSENRCGGNFLKRGSI---INGADWYSFTGGMSDFNYLHTNCFEITVEL 462
AY+ +P M D + C N + NG WYS GGM DFNYL +NCFEITVEL
Sbjct: 284 AYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVEL 343
Query: 463 GCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDIT 522
C KFPPEE L T W+ NK SL++++E +HRG+KG V D G P+ NA ISV+GI HD+T
Sbjct: 344 SCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVT 403
Query: 523 TAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQ 571
+A DGDYWRLL PG + + A APGY + KKV +P A VDF L+
Sbjct: 404 SAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVP--YSPAAGVDFELE 450
>gi|9994201 carboxypeptidase X, member 1 precursor [Homo sapiens]
Length = 734
Score = 394 bits (1011), Expect = e-109
Identities = 194/388 (50%), Positives = 264/388 (68%), Gaps = 10/388 (2%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F HH+Y M +++++ +C ++ R YSIG+S+ G +L V+E S +PG+HEL EPEV+ +
Sbjct: 297 FQHHNYKAMRKLMKQVQEQCPNITRIYSIGKSYQGLKLYVMEMSDKPGEHELGEPEVRYV 356
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
+HGNE GRE+L+ L Q+LC E+L GNPR+ RLL+ RIHLLPSMNPDGYE+A G+
Sbjct: 357 AGMHGNEALGRELLLLLMQFLCHEFLRGNPRVTRLLSEMRIHLLPSMNPDGYEIAYHRGS 416
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRG-----ARSDHIPIPQHYWW--GKV 346
GW GR N Q++DLN NF DL + + A+ G + H+P+P +Y V
Sbjct: 417 ELVGWAEGRWNNQSIDLNHNFADLNTPLWE-AQDDGKVPHIVPNHHLPLPTYYTLPNATV 475
Query: 347 APETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRA 406
APET+A++KWM+ IPFVLSA+LHGG+LVVSYPFD ++ P + +PTPD+ +F+ LS
Sbjct: 476 APETRAVIKWMKRIPFVLSANLHGGELVVSYPFDMTRTPWAARELTPTPDDAVFRWLSTV 535
Query: 407 YADVHPMMMDRSENRC-GGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCV 465
YA + M D S C +F G+IINGADW++ G M+DF+YLHTNCFE+TVEL C
Sbjct: 536 YAGSNLAMQDTSRRPCHSQDFSVHGNIINGADWHTVPGSMNDFSYLHTNCFEVTVELSCD 595
Query: 466 KFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGK-PVKNARISVKGIRHDITTA 524
KFP E L W++NK++LL ++E V GI GVV DK + + +A I+V GI HD+TTA
Sbjct: 596 KFPHENELPQEWENNKDALLTYLEQVRMGIAGVVRDKDTELGIADAVIAVDGINHDVTTA 655
Query: 525 PDGDYWRLLPPGIHIVIAQAPGYAKVIK 552
GDYWRLL PG ++V A A GY V +
Sbjct: 656 WGGDYWRLLTPGDYMVTASAEGYHSVTR 683
>gi|4503011 carboxypeptidase N, polypeptide 1 precursor [Homo
sapiens]
Length = 458
Score = 387 bits (993), Expect = e-107
Identities = 193/380 (50%), Positives = 253/380 (66%), Gaps = 10/380 (2%)
Query: 172 IRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVK 231
+ F HH Y +VR L + + C + R YSIGRS +GR L V+EFS PG HE +EPEVK
Sbjct: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80
Query: 232 LIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAE 291
+GN+HGNE GRE+++ L+++LC E+ N RI +L+ TRIH+LPSMNPDGYEVAAA+
Sbjct: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140
Query: 292 GAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETK 351
G G+ GR NA +DLNRNFPDL + Y E G + H+P+P + W +V PET+
Sbjct: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNT-YIYYNEKYGGPNHHLPLPDN-WKSQVEPETR 198
Query: 352 AIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ----EEKMFSPTPDEKMFKLLSRAY 407
A+++WM + FVLSA+LHGG +V +YP+D S + +PTPD+K+F+ L++ Y
Sbjct: 199 AVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258
Query: 408 ADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKF 467
+ H M CG F I NGA WYS + GM DFNYLHTNCFEIT+EL C KF
Sbjct: 259 SYAHGWMFQGW--NCGDYF--PDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKF 314
Query: 468 PPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDG 527
PPEE L W N+E+L+ F+E VH+GIKG+V D+ + NA ISV GI HD+T+ G
Sbjct: 315 PPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHG 374
Query: 528 DYWRLLPPGIHIVIAQAPGY 547
DY+RLL PGI+ V A APGY
Sbjct: 375 DYFRLLLPGIYTVSATAPGY 394
>gi|223005864 carboxypeptidase X (M14 family), member 2 [Homo
sapiens]
Length = 756
Score = 368 bits (945), Expect = e-102
Identities = 185/414 (44%), Positives = 260/414 (62%), Gaps = 18/414 (4%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F HH+Y +M ++++ C ++ R Y+IG+S G +L +E S PG+HE+ EPE I
Sbjct: 316 FKHHNYKEMRQLMKVVNEMCPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYI 375
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
HGNEV GRE+L+ L Q++C EYL N RI L+ TRIH+LPS+NPDGYE A G+
Sbjct: 376 AGAHGNEVLGRELLLLLVQFVCQEYLARNARIVHLVEETRIHVLPSLNPDGYEKAYEGGS 435
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIP--IPQHY-----WW--- 343
GW+ GR +D+N NFPDL + + AE R ++P +P HY W+
Sbjct: 436 ELGGWSLGRWTHDGIDINNNFPDLNTLLWE-AEDR----QNVPRKVPNHYIAIPEWFLSE 490
Query: 344 -GKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKL 402
VA ET+A++ WM+ IPFVL +L GG+LVV+YP+D + P + + +PTPD+ +F+
Sbjct: 491 NATVAAETRAVIAWMEKIPFVLGGNLQGGELVVAYPYDLVRSPWKTQEHTPTPDDHVFRW 550
Query: 403 LSRAYADVHPMMMDRSENRCGG-NFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVE 461
L+ +YA H +M D C +F K +NGA W++ G ++DF+YLHTNCFE+++
Sbjct: 551 LAYSYASTHRLMTDARRRVCHTEDFQKEEGTVNGASWHTVAGSLNDFSYLHTNCFELSIY 610
Query: 462 LGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDI 521
+GC K+P E L W++N+ESL+ F+E VHRGIKG+V D GK + NA ISV+GI HDI
Sbjct: 611 VGCDKYPHESQLPEEWENNRESLIVFMEQVHRGIKGLVRDSHGKGIPNAIISVEGINHDI 670
Query: 522 TTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGM 575
TA DGDYWRLL PG ++V A+A G+ K ++ M A R DF L M
Sbjct: 671 RTANDGDYWRLLNPGEYVVTAKAEGFTASTKNCMVGYDM-GATRCDFTLSKTNM 723
>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
sapiens]
Length = 1158
Score = 342 bits (877), Expect = 6e-94
Identities = 175/404 (43%), Positives = 243/404 (60%), Gaps = 25/404 (6%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F HHSY M ++++ C + RTYS+G+S G ++ +E S PG+HEL EPE +
Sbjct: 562 FRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYT 621
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
IHGNEV GRE+L+ L QYLC EY GNPR++ L+ TRIHL+PS+NPDGYEVAA G+
Sbjct: 622 AGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGS 681
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETR----GARSDHIPIPQHYWW--GKVA 347
+ W G + D+ +FPDL S + E + ++++PIP+ Y V+
Sbjct: 682 EFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVS 741
Query: 348 PETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFS--------------- 392
E +AI+ WM+ PFVL A+L+GG+ +VSYP+D ++ P +E++ +
Sbjct: 742 TEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVS 801
Query: 393 ---PTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRG-SIINGADWYSFTGGMSDF 448
TPD +F+ L+ ++A H + + C G I+NGA W TG ++DF
Sbjct: 802 EAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDF 861
Query: 449 NYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVK 508
+YLHTNC E++ LGC KFP E L W++NKE+LL F+E VHRGIKGVVTD+ G P+
Sbjct: 862 SYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIA 921
Query: 509 NARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIK 552
NA ISV GI H + TA GDYWR+L PG + V A A GY K
Sbjct: 922 NATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAK 965
>gi|22202611 carboxypeptidase D precursor [Homo sapiens]
Length = 1380
Score = 320 bits (820), Expect = 3e-87
Identities = 175/400 (43%), Positives = 243/400 (60%), Gaps = 33/400 (8%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F HH + M LRR A+ ++ R YS+G+S + REL V+E S PG HE EPE K I
Sbjct: 501 FHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYI 560
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
GN+HGNEV GRE+L+ L +YLC + +P + L++ TRIHL+PSMNPDGYE + EG
Sbjct: 561 GNMHGNEVVGRELLLNLIEYLCKNFGT-DPEVTDLVHNTRIHLMPSMNPDGYE-KSQEGD 618
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 353
+ GR N+ N DLNRNFPD ++ ++ + PET A+
Sbjct: 619 SIS--VIGRNNSNNFDLNRNFPD---QFVQITDP------------------TQPETIAV 655
Query: 354 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPM 413
M WM++ PFVLSA+LHGG LVV+YPFD + Q +S +PD+ +F+ ++ +Y+ +
Sbjct: 656 MSWMKSYPFVLSANLHGGSLVVNYPFDDDE--QGLATYSKSPDDAVFQQIALSYSKENSQ 713
Query: 414 MMDRS--ENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEE 471
M +N + G I NGA WY+ GGM D+NYL TNCFE+T+ELGCVK+P E+
Sbjct: 714 MFQGRPCKNMYPNEYFPHG-ITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEK 772
Query: 472 ALYTLWQHNKESLLNFVETVHRGIKGVVTDKF-GKPVKNARISVKGIRHDITTAPDGDYW 530
L W+ N+ SL+ F++ VH+G++G V D G+ + NA ISV I H +TT GDYW
Sbjct: 773 ELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYW 832
Query: 531 RLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFIL 570
RLL PG + + A A GY V K V + + + A +V+F L
Sbjct: 833 RLLVPGTYKITASARGYNPVTKNVTV--KSEGAIQVNFTL 870
Score = 280 bits (717), Expect = 2e-75
Identities = 170/431 (39%), Positives = 241/431 (55%), Gaps = 53/431 (12%)
Query: 171 FIRFSHHSYAQMVRVLRRTASR-CAHVARTYSIGRSFDGRELLVIEFSSRPGQ------- 222
F R+ H ++ LR A+ +AR +SIGRS +GR L V+ ++ G
Sbjct: 55 FDRYYHEE--ELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDA 112
Query: 223 ----------HELM--EPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLN 270
L+ P+VKL+GN+HG+E R++LIYLA+ L + Y G+PR+ RLLN
Sbjct: 113 GPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLN 172
Query: 271 TTRIHLLPSMNPDGYEVAAAEGAGYN----GWTSGRQNAQNLDLNRNFPDL--TSEYYRL 324
TT ++LLPS+NPDG+E A G+ SGR N++ DLNR+FPD T E L
Sbjct: 173 TTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPAL 232
Query: 325 AETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKH 384
E PE +A+++W++ FVLS +LHGG +V SYPFD S
Sbjct: 233 DEV--------------------PEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPE 272
Query: 385 PQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLK--RGSIINGADWYSFT 442
+ ++S T D+++FK L++AYA HP+M E C G+ + + I NGA WY
Sbjct: 273 HKATGIYSKTSDDEVFKYLAKAYASNHPIMKT-GEPHCPGDEDETFKDGITNGAHWYDVE 331
Query: 443 GGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDK 502
GGM D+NY+ NCFEIT+EL C K+PP L W++N+ESL+ +E VH G+KG V D
Sbjct: 332 GGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDS 391
Query: 503 F-GKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMK 561
G ++NA ISV GI H+ITT GD++RLL PG + + GY + ++ +
Sbjct: 392 ITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVV-VKEG 450
Query: 562 RAGRVDFILQP 572
A VDF L+P
Sbjct: 451 PATEVDFSLRP 461
Score = 197 bits (502), Expect = 2e-50
Identities = 135/423 (31%), Positives = 209/423 (49%), Gaps = 57/423 (13%)
Query: 148 DPLEKLRGGLEADEALPSGLPPTFIRFS---------HHSYAQMVRVLRRTASRCAHVAR 198
DP K L D + +GL +R S +HSY + LR H+
Sbjct: 896 DPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITN 955
Query: 199 TYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEY 258
++G+S + R + +E S++P E EP+++ + IHGN G E+L+ LA++LC Y
Sbjct: 956 LTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNY 1015
Query: 259 LLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLT 318
NP + +L++ TRI ++PS+NPDG E A + G+ NA+ DL+ +F +
Sbjct: 1016 KK-NPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSK---IGQTNARGKDLDTDFTNNA 1071
Query: 319 SEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMK-WMQTIPFVLSASLHGGDLVVSY 377
S+ PETKAI++ +Q F LS +L GG ++V+Y
Sbjct: 1072 SQ---------------------------PETKAIIENLIQKQDFSLSVALDGGSMLVTY 1104
Query: 378 PFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMM---MDRSENRCGGNFLKRGSIIN 434
P+D K +++ K L+ YA+ HP M N+ N G ++
Sbjct: 1105 PYD--------KPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENI--PGGVMR 1154
Query: 435 GADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRG 494
GA+W+S G M D++ + +C EITV C FP L +LW NK SLL+ + VH+G
Sbjct: 1155 GAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKG 1214
Query: 495 IKGVVTDKFGKPVKNARISV-KGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKK 553
+ G V DK GKP+ A I + +GI+ + T G + LL PG+H +IA A GY + +
Sbjct: 1215 VHGFVKDKTGKPISKAVIVLNEGIK--VQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQ 1272
Query: 554 VII 556
V +
Sbjct: 1273 VFV 1275
>gi|53832021 carboxypeptidase M precursor [Homo sapiens]
Length = 443
Score = 266 bits (681), Expect = 3e-71
Identities = 153/389 (39%), Positives = 212/389 (54%), Gaps = 30/389 (7%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F++H M L+ A + V +SIG+S GR L V+ P +H + PE K +
Sbjct: 20 FNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYV 79
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
N+HG+E GRE+L++L YL + +P I L+N+TRIH++PSMNPDG+E
Sbjct: 80 ANMHGDETVGRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDC 138
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 353
Y+ GR+N DLNRNFPD EY ++ PET A+
Sbjct: 139 YYS---IGRENYNQYDLNRNFPD-AFEYNNVSRQ--------------------PETVAV 174
Query: 354 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMF-SPTPDEKMFKLLSRAYADVHP 412
MKW++T FVLSA+LHGG LV SYPFD S TPD+ +F+ L+ YA +P
Sbjct: 175 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNP 234
Query: 413 MMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEA 472
M E + NF + NG WY GGM D+NY+ CFEIT+EL C K+P EE
Sbjct: 235 NMKKGDECKNKMNF--PNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEK 292
Query: 473 LYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRH--DITTAPDGDYW 530
L + W +NK SL+ +++ VH G+KG V D+ G P+ N + V+ +H T G+Y+
Sbjct: 293 LPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYY 352
Query: 531 RLLPPGIHIVIAQAPGYAKVIKKVIIPAR 559
LL PG +I+ PG+ I KVIIP +
Sbjct: 353 LLLLPGSYIINVTVPGHDPHITKVIIPEK 381
>gi|38327526 carboxypeptidase M precursor [Homo sapiens]
Length = 443
Score = 266 bits (681), Expect = 3e-71
Identities = 153/389 (39%), Positives = 212/389 (54%), Gaps = 30/389 (7%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F++H M L+ A + V +SIG+S GR L V+ P +H + PE K +
Sbjct: 20 FNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYV 79
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
N+HG+E GRE+L++L YL + +P I L+N+TRIH++PSMNPDG+E
Sbjct: 80 ANMHGDETVGRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDC 138
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 353
Y+ GR+N DLNRNFPD EY ++ PET A+
Sbjct: 139 YYS---IGRENYNQYDLNRNFPD-AFEYNNVSRQ--------------------PETVAV 174
Query: 354 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMF-SPTPDEKMFKLLSRAYADVHP 412
MKW++T FVLSA+LHGG LV SYPFD S TPD+ +F+ L+ YA +P
Sbjct: 175 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNP 234
Query: 413 MMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEA 472
M E + NF + NG WY GGM D+NY+ CFEIT+EL C K+P EE
Sbjct: 235 NMKKGDECKNKMNF--PNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEK 292
Query: 473 LYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRH--DITTAPDGDYW 530
L + W +NK SL+ +++ VH G+KG V D+ G P+ N + V+ +H T G+Y+
Sbjct: 293 LPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYY 352
Query: 531 RLLPPGIHIVIAQAPGYAKVIKKVIIPAR 559
LL PG +I+ PG+ I KVIIP +
Sbjct: 353 LLLLPGSYIINVTVPGHDPHITKVIIPEK 381
>gi|6631081 carboxypeptidase M precursor [Homo sapiens]
Length = 443
Score = 266 bits (681), Expect = 3e-71
Identities = 153/389 (39%), Positives = 212/389 (54%), Gaps = 30/389 (7%)
Query: 174 FSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLI 233
F++H M L+ A + V +SIG+S GR L V+ P +H + PE K +
Sbjct: 20 FNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYV 79
Query: 234 GNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGA 293
N+HG+E GRE+L++L YL + +P I L+N+TRIH++PSMNPDG+E
Sbjct: 80 ANMHGDETVGRELLLHLIDYLVTSDGK-DPEITNLINSTRIHIMPSMNPDGFEAVKKPDC 138
Query: 294 GYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAI 353
Y+ GR+N DLNRNFPD EY ++ PET A+
Sbjct: 139 YYS---IGRENYNQYDLNRNFPD-AFEYNNVSRQ--------------------PETVAV 174
Query: 354 MKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMF-SPTPDEKMFKLLSRAYADVHP 412
MKW++T FVLSA+LHGG LV SYPFD S TPD+ +F+ L+ YA +P
Sbjct: 175 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSRSLTPDDDVFQYLAHTYASRNP 234
Query: 413 MMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEA 472
M E + NF + NG WY GGM D+NY+ CFEIT+EL C K+P EE
Sbjct: 235 NMKKGDECKNKMNF--PNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREEK 292
Query: 473 LYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRH--DITTAPDGDYW 530
L + W +NK SL+ +++ VH G+KG V D+ G P+ N + V+ +H T G+Y+
Sbjct: 293 LPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEYY 352
Query: 531 RLLPPGIHIVIAQAPGYAKVIKKVIIPAR 559
LL PG +I+ PG+ I KVIIP +
Sbjct: 353 LLLLPGSYIINVTVPGHDPHITKVIIPEK 381
>gi|4503827 frizzled 2 [Homo sapiens]
Length = 565
Score = 70.9 bits (172), Expect = 3e-12
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 13/140 (9%)
Query: 6 PLLLLTVLVVAAARPGCEFERNPAAT------CVDLQLRTCSDAAYNHTTFPNLLQHRSW 59
P LLL +L++ AA P +F + C + + C+D AYN T PNLL H +
Sbjct: 8 PRLLLPLLLLPAAGPA-QFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQ 66
Query: 60 EVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG-GWVRRPCRHICEGLREVC 118
E +A E + + L++ QC+P+LR C++ AP C PCR ICE R+ C
Sbjct: 67 E--DAGLE---VHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGC 121
Query: 119 QPAFDAIDMAWPYFLDCHRY 138
+ + WP L C +
Sbjct: 122 EALMNKFGFQWPERLRCEHF 141
>gi|6005762 frizzled 10 [Homo sapiens]
Length = 581
Score = 70.1 bits (170), Expect = 6e-12
Identities = 55/180 (30%), Positives = 75/180 (41%), Gaps = 10/180 (5%)
Query: 2 PPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEV 61
P P L+L V+ AA + ER C +++ C D YN T PNL+ H +
Sbjct: 4 PGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQR- 62
Query: 62 VEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRP---CRHICEGLREVC 118
EA+ I L L+E C+ LR C++ AP C V P CR +CE R C
Sbjct: 63 -EAA---IQLHEFAPLVEYGCHGHLRFFLCSLYAPMCT-EQVSTPIPACRVMCEQARLKC 117
Query: 119 QPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHS 178
P + + WP LDC + + D Y +E G + PP F HS
Sbjct: 118 SPIMEQFNFKWPDSLDCRKLPNKNDPN-YLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHS 176
>gi|27894385 frizzled 5 precursor [Homo sapiens]
Length = 585
Score = 68.2 bits (165), Expect = 2e-11
Identities = 45/141 (31%), Positives = 62/141 (43%), Gaps = 16/141 (11%)
Query: 2 PPPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEV 61
P PP LLL +L R + A C ++ + C YN T PN H + +
Sbjct: 6 PSAPPSLLLLLLAQLVGRAAAA---SKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQD- 61
Query: 62 VEASSEYILLSVLHQ---LLEGQCNPDLRLLGCAVLAPRCEGGWVR--RPCRHICEGLRE 116
EA E +HQ L+E QC+PDLR C++ P C + + PCR +CE +
Sbjct: 62 -EAGLE------VHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKA 114
Query: 117 VCQPAFDAIDMAWPYFLDCHR 137
C P AWP + C R
Sbjct: 115 GCSPLMRQYGFAWPERMSCDR 135
>gi|8393378 frizzled 3 [Homo sapiens]
Length = 666
Score = 68.2 bits (165), Expect = 2e-11
Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 11/124 (8%)
Query: 31 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 90
+C + LR C D YN T PNLL H + + + + H ++ C+ D R
Sbjct: 27 SCEPITLRMCQDLPYNTTFMPNLLNH-----YDQQTAALAMEPFHPMVNLDCSRDFRPFL 81
Query: 91 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149
CA+ AP C E G V PCR +C+ C + + WP ++C R+ C +P
Sbjct: 82 CALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRF-----PDCDEP 136
Query: 150 LEKL 153
+L
Sbjct: 137 YPRL 140
>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
Length = 317
Score = 67.4 bits (163), Expect = 4e-11
Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 8/119 (6%)
Query: 21 GCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLE 79
G + + P + L C Y PNLL+H S EV + +S ++ LL
Sbjct: 44 GRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWL------PLLA 97
Query: 80 GQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138
+C+ D ++ C++ AP C + PCR +CE +R C P +A WP L CH++
Sbjct: 98 KRCHSDTQVFLCSLFAPVCLDRPIY-PCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKF 155
>gi|4503833 frizzled 7 [Homo sapiens]
Length = 574
Score = 66.2 bits (160), Expect = 9e-11
Identities = 36/108 (33%), Positives = 54/108 (50%), Gaps = 6/108 (5%)
Query: 32 CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 91
C + + C+D AYN T PNLL H + E +A E + + L++ QC+P+LR C
Sbjct: 49 CQPISIPLCTDIAYNQTILPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSPELRFFLC 103
Query: 92 AVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138
++ AP C PCR +CE R+ C+ + WP L C +
Sbjct: 104 SMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENF 151
>gi|4503835 frizzled 9 [Homo sapiens]
Length = 591
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/118 (36%), Positives = 57/118 (48%), Gaps = 9/118 (7%)
Query: 29 AATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRL 88
AA C +++ C YN T PNLL H S EA++E L+ L++ C+ LR
Sbjct: 36 AAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQG--EAAAE---LAEFAPLVQYGCHSHLRF 90
Query: 89 LGCAVLAPRCEGGWVRRP---CRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTRED 143
C++ AP C V P CR +CE R C P + + WP LDC R TR D
Sbjct: 91 FLCSLYAPMCTDQ-VSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRND 147
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 65.1 bits (157), Expect = 2e-10
Identities = 33/114 (28%), Positives = 53/114 (46%), Gaps = 5/114 (4%)
Query: 27 NPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDL 86
N + C + L C + YN T++PN HR+ + S E S+ L++ C L
Sbjct: 450 NNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWES---SLFPALVQTNCYKYL 506
Query: 87 RLLGCAVLAPRCE--GGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138
C +L P+C+ G PCR +CE +E C+ + + WP DC ++
Sbjct: 507 MFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQF 560
Score = 56.2 bits (134), Expect = 9e-08
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 16/145 (11%)
Query: 17 AARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQ 76
A+ PG + RN +A C+++ C Y+ T P L R+ E+ + + + LH+
Sbjct: 125 ASLPGDQSHRNTSA-CMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFF---TYLHR 180
Query: 77 LLEGQCNPDLRLLGCAVLAPRC----EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYF 132
L C + L GC + P C + PCR CE +E C+ ++ +WP F
Sbjct: 181 L---SCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDF 237
Query: 133 LDCHRYFTREDEG-----CYDPLEK 152
L C ++ + + C+ P ++
Sbjct: 238 LRCSQFRNQTESSNVSRICFSPQQE 262
>gi|34734079 frizzled 6 [Homo sapiens]
Length = 706
Score = 63.9 bits (154), Expect = 4e-10
Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 6/108 (5%)
Query: 31 TCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLG 90
TC + + C AYN T FPNL+ H + E+ L L +C+P++
Sbjct: 23 TCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFL-----PLANLECSPNIETFL 77
Query: 91 CAVLAPRC-EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHR 137
C P C E V PCR +CE + C+ D + WP L+C R
Sbjct: 78 CKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDR 125
>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
Length = 314
Score = 63.5 bits (153), Expect = 6e-10
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 10/110 (9%)
Query: 32 CVDL--QLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRL 88
CVD+ LR C + Y PNLL+H + EV + +S ++ LL C+ ++
Sbjct: 58 CVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWV------PLLNKNCHAGTQV 111
Query: 89 LGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138
C++ AP C + PCR +CE +R+ C+P WP L C ++
Sbjct: 112 FLCSLFAPVCLDRPIY-PCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKF 160
>gi|4503825 frizzled 1 [Homo sapiens]
Length = 647
Score = 63.2 bits (152), Expect = 7e-10
Identities = 34/108 (31%), Positives = 54/108 (50%), Gaps = 6/108 (5%)
Query: 32 CVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 91
C + + C+D AYN T PNLL H + E +A E + + L++ QC+ +L+ C
Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQE--DAGLE---VHQFYPLVKVQCSAELKFFLC 170
Query: 92 AVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRY 138
++ AP C PCR +CE R+ C+ + WP L C ++
Sbjct: 171 SMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKF 218
>gi|13994190 frizzled 8 [Homo sapiens]
Length = 694
Score = 61.2 bits (147), Expect = 3e-09
Identities = 39/134 (29%), Positives = 57/134 (42%), Gaps = 13/134 (9%)
Query: 9 LLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEY 68
LL L + G C ++ + C YN+T PN H + + EA E
Sbjct: 12 LLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQD--EAGLE- 68
Query: 69 ILLSVLHQ---LLEGQCNPDLRLLGCAVLAPRCEGGWVRR--PCRHICEGLREVCQPAFD 123
+HQ L+E QC+PDL+ C++ P C + + PCR +CE + C P
Sbjct: 69 -----VHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMR 123
Query: 124 AIDMAWPYFLDCHR 137
AWP + C R
Sbjct: 124 QYGFAWPDRMRCDR 137
>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
sapiens]
Length = 295
Score = 60.8 bits (146), Expect = 4e-09
Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 11/135 (8%)
Query: 33 VDLQLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 91
+ L+ C Y + PNLL H + EV+E + +I L+ QC+PD + C
Sbjct: 43 IPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWI------PLVMKQCHPDTKKFLC 96
Query: 92 AVLAPRC--EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149
++ AP C + +PC +C +++ C P A WP L+C R F ++++ C P
Sbjct: 97 SLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDR-FPQDNDLCI-P 154
Query: 150 LEKLRGGLEADEALP 164
L L A E P
Sbjct: 155 LASSDHLLPATEEAP 169
>gi|38455388 frizzled-related protein [Homo sapiens]
Length = 325
Score = 60.5 bits (145), Expect = 5e-09
Identities = 41/150 (27%), Positives = 61/150 (40%), Gaps = 8/150 (5%)
Query: 3 PPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVV 62
P LLL L+ AA AA C +++ C +N T PN L H +
Sbjct: 6 PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHST---- 61
Query: 63 EASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVR---RPCRHICEGLREVCQ 119
++ + + LL C+PDL CA+ AP C + +PC+ +CE R+ C+
Sbjct: 62 -QANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120
Query: 120 PAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149
P +WP L C + C P
Sbjct: 121 PILIKYRHSWPENLACEELPVYDRGVCISP 150
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 60.5 bits (145), Expect = 5e-09
Identities = 42/126 (33%), Positives = 54/126 (42%), Gaps = 12/126 (9%)
Query: 28 PAATCVDLQLRTCSDAAYNHTTFPNLL--QHRSWEVVEASSEYILLSVLHQLLEGQCNPD 85
P C +Q+ C +YN T FPN+ EVVE S Y L+ L C
Sbjct: 462 PELACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSL------PCYQH 515
Query: 86 LRLLGCAVLAPRCEG-GWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTRED- 143
R L C +L PRC G V PCR +C+ CQ + WP+ +C+R D
Sbjct: 516 FRRLLCGLLVPRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWPF--NCNRLPEAADL 573
Query: 144 EGCYDP 149
E C P
Sbjct: 574 EACAQP 579
>gi|61743916 carboxypeptidase A4 preproprotein [Homo sapiens]
Length = 421
Score = 60.1 bits (144), Expect = 6e-09
Identities = 61/241 (25%), Positives = 102/241 (42%), Gaps = 22/241 (9%)
Query: 175 SHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIG 234
++HS + + A+ +AR IG SF+ R + V++FS+ G + P V L
Sbjct: 122 AYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKG---VRRPAVWLNA 178
Query: 235 NIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAG 294
IH E + I+ A+ + S+Y +P I +L I LLP NPDGY +
Sbjct: 179 GIHSREWISQATAIWTARKIVSDY-QRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRL 237
Query: 295 YNGWTSGRQNAQ--NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKA 352
+ S + D NRN + +GA + H E K+
Sbjct: 238 WRKTRSRNPGSSCIGADPNRN-------WNASFAGKGASDNPCSEVYHGPHANSEVEVKS 290
Query: 353 IMKWMQTI-PFVLSASLHGGDLVVSYPFDFS--KHPQEEKMFSPTPDEKMFKLLSRAYAD 409
++ ++Q F LH ++ YP+ +S K P E++ +K+ +L ++A A
Sbjct: 291 VVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEEL------DKVARLAAKALAS 344
Query: 410 V 410
V
Sbjct: 345 V 345
>gi|22547161 frizzled 4 [Homo sapiens]
Length = 537
Score = 57.0 bits (136), Expect = 5e-08
Identities = 39/140 (27%), Positives = 65/140 (46%), Gaps = 12/140 (8%)
Query: 7 LLLLTVLVVAAARP-GCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEAS 65
LLL +L++ AR G E ER C +++ C + YN T PNL+ H ++
Sbjct: 23 LLLQLLLLLGPARGFGDEEERR----CDPIRISMCQNLGYNVTKMPNLVGHE----LQTD 74
Query: 66 SEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG--GWVRRPCRHICEGLREVCQPAFD 123
+E + L+ L++ C+ L+ C+V P C PC +C ++ C+P
Sbjct: 75 AE-LQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLK 133
Query: 124 AIDMAWPYFLDCHRYFTRED 143
AWP L+C ++ + D
Sbjct: 134 EFGFAWPESLNCSKFPPQND 153
>gi|170784838 secreted frizzled-related protein 4 [Homo sapiens]
Length = 346
Score = 56.2 bits (134), Expect = 9e-08
Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 8/123 (6%)
Query: 30 ATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLL 89
A C +++ C +N T PN L H + E + + + +L++ C+ LR
Sbjct: 22 APCEAVRIPMCRHMPWNITRMPNHLHHSTQE-----NAILAIEQYEELVDVNCSAVLRFF 76
Query: 90 GCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGC 146
CA+ AP C ++ +PC+ +C+ R+ C+P + +WP L C + C
Sbjct: 77 LCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVC 136
Query: 147 YDP 149
P
Sbjct: 137 ISP 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,507,253
Number of Sequences: 37866
Number of extensions: 1394378
Number of successful extensions: 3222
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 3086
Number of HSP's gapped (non-prelim): 62
length of query: 641
length of database: 18,247,518
effective HSP length: 109
effective length of query: 532
effective length of database: 14,120,124
effective search space: 7511905968
effective search space used: 7511905968
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.