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Search of human proteins with 61743918
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61743918 cytochrome P450, family 11, subfamily B,
polypeptide 1 isoform 1 precursor [Homo sapiens]
(503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide... 1013 0.0
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid... 943 0.0
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide... 807 0.0
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid... 331 8e-91
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid... 244 1e-64
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 212 7e-55
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ... 207 2e-53
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ... 194 1e-49
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid... 166 6e-41
gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1... 151 1e-36
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide... 103 5e-22
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 101 2e-21
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 97 3e-20
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 95 2e-19
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 93 5e-19
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide... 91 2e-18
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8... 90 5e-18
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7... 89 7e-18
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 87 5e-17
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H... 82 9e-16
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H... 82 9e-16
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 81 2e-15
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 80 3e-15
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 80 3e-15
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11... 80 3e-15
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11... 80 3e-15
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide... 80 6e-15
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ... 79 1e-14
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ... 78 2e-14
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide... 78 2e-14
>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 503
Score = 1013 bits (2618), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
Query: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
Sbjct: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
Sbjct: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
Sbjct: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420
Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
Sbjct: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480
Query: 481 IKMVYSFILRPSMFPLLTFRAIN 503
IKMVYSFILRPSMFPLLTFRAIN
Sbjct: 481 IKMVYSFILRPSMFPLLTFRAIN 503
>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
precursor [Homo sapiens]
Length = 503
Score = 943 bits (2437), Expect = 0.0
Identities = 469/503 (93%), Positives = 480/503 (95%)
Query: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
MALRAKAEVC+A PWLSLQRA+ALGTRAAR PRTVLPFEAMP+ PGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG 60
Query: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
YE LHLE+HQTFQELGPIFRY+LGG MVCVMLPEDVEKLQQVDSLHP RM LEPWVAYR
Sbjct: 61 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR 120
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
QHRGHKCGVFLLNGPEWRFNRLRLNP+VLSP AVQRFLPMVDAVARDFSQALKKKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA 180
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
PRSLSRW SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF+RPQ YT IVAELLL AELS
Sbjct: 241 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS 300
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
+AIKANSMELTAGSVDTT FPLLMTLFELARNP+VQQ LRQESLAAAASISEHPQKATT
Sbjct: 301 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT 360
Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420
ELPLLRAALKETLRLYPVGLFLERV SSDLVLQNYHIPAGTLV+VFLYSLGRN ALFPRP
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP 420
Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480
ERYNPQRWLDIRGSGRNF+HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH VETLTQED
Sbjct: 421 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED 480
Query: 481 IKMVYSFILRPSMFPLLTFRAIN 503
IKMVYSFILRP PLLTFRAIN
Sbjct: 481 IKMVYSFILRPGTSPLLTFRAIN 503
>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 437
Score = 807 bits (2084), Expect = 0.0
Identities = 406/429 (94%), Positives = 410/429 (95%), Gaps = 11/429 (2%)
Query: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
Query: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
Sbjct: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
Sbjct: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
Sbjct: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRV-----------FLYS 409
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAG L + +YS
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLTQEDIKMVYS 420
Query: 410 LGRNPALFP 418
P++FP
Sbjct: 421 FILRPSMFP 429
Score = 79.3 bits (194), Expect = 7e-15
Identities = 41/54 (75%), Positives = 47/54 (87%), Gaps = 4/54 (7%)
Query: 454 RLAEAEMLLLLHH----VLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503
R+A ++++L +H VLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
Sbjct: 384 RVASSDLVLQNYHIPAGVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 437
>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform a precursor [Homo sapiens]
Length = 521
Score = 331 bits (849), Expect = 8e-91
Identities = 186/481 (38%), Positives = 269/481 (55%), Gaps = 2/481 (0%)
Query: 25 GTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLG 84
G A R+ PF +P N WL L WRE G +HL Q FQ+ GPI+R LG
Sbjct: 35 GEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLG 94
Query: 85 GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144
V V+ PEDV L + + +P R + PWVAY Q+ GV L W+ +R+ L
Sbjct: 95 NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154
Query: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204
N EV++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +
Sbjct: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214
Query: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF 264
FGER G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF
Sbjct: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274
Query: 265 QYGDNCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFP 322
D Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT
Sbjct: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334
Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382
L L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L
Sbjct: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394
Query: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 442
+R +DLVL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++
Sbjct: 395 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG 454
Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAI 502
FG+G+RQCLGRR+AE EM + L ++L++ +VE D+ ++ IL P TF
Sbjct: 455 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPF 514
Query: 503 N 503
N
Sbjct: 515 N 515
>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
isoform b [Homo sapiens]
Length = 363
Score = 244 bits (624), Expect = 1e-64
Identities = 137/357 (38%), Positives = 206/357 (57%), Gaps = 2/357 (0%)
Query: 149 LSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208
++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER
Sbjct: 1 MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER 60
Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268
G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D
Sbjct: 61 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 120
Query: 269 NCIQKIYQELAF--SRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326
Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L
Sbjct: 121 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 180
Query: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386
L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R
Sbjct: 181 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 240
Query: 387 SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFG 446
+DLVL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++ FG+G
Sbjct: 241 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 300
Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503
+RQCLGRR+AE EM + L ++L++ +VE D+ ++ IL P TF N
Sbjct: 301 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 357
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 212 bits (539), Expect = 7e-55
Identities = 146/435 (33%), Positives = 208/435 (47%), Gaps = 16/435 (3%)
Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
L +++ + G LH Q GP++ G V V P VE+L + + P R
Sbjct: 49 LAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERC 108
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
S PW +R+ R CG+ G EW+ R L P +L P A R+ ++ V D +
Sbjct: 109 SFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRR 168
Query: 172 LKKKVLQNARGS----LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227
L++ Q RG+ L DV + + +E L G RLG + + F+ A+
Sbjct: 169 LRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAV 225
Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF---SRPQ 284
+F ST+ M MP L R P W WD +F + +++ E A +P+
Sbjct: 226 GSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPE 284
Query: 285 QYTSIVAEL---LLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALR 341
+ A L L EL +I N EL VDT L L+EL+R+P VQ AL
Sbjct: 285 KDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALH 344
Query: 342 QESLAAAASISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPA 399
E AA + S AT ++LPLL+A +KE LRLYPV RV D+ + +Y IP
Sbjct: 345 SEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPK 404
Query: 400 GTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459
TLV + Y+ R+PA FP P + P RWL + F +PFGFG R C+GRRLAE E
Sbjct: 405 NTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELE 464
Query: 460 MLLLLHHVLKHLQVE 474
+ + L +L H +V+
Sbjct: 465 LQMALAQILTHFEVQ 479
>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 1 precursor [Homo sapiens]
Length = 514
Score = 207 bits (526), Expect = 2e-53
Identities = 129/441 (29%), Positives = 221/441 (50%), Gaps = 6/441 (1%)
Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
LLQI + G + H + + ++ G IFR LG V + P +E L + +S +P R+
Sbjct: 70 LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
++PW AYR +R G+ +L G +W+ R +++ P V + ++ V DF
Sbjct: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231
+ + L + RG + D+ + ++ E+ L L+ +R GL+ + ++NF+ A++ M
Sbjct: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291
+ ++M P L + + KVW++H AWD IF+ CI ++ + Q +
Sbjct: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
++ LS + A EL +V+TT L+ L+ L+RNP VQQ L +E +
Sbjct: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411
+ +P L+A LKE++RL P F R VL Y +P GT++ + LG
Sbjct: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLG 423
Query: 412 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471
+ F ++ P+RWL + F H+PFG G R C+GRRLAE ++ L L +++
Sbjct: 424 SSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKY 483
Query: 472 QVETLTQEDIKMVYSFILRPS 492
++ E ++M++S L PS
Sbjct: 484 DIQATDNEPVEMLHSGTLVPS 504
>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
precursor [Homo sapiens]
Length = 531
Score = 194 bits (494), Expect = 1e-49
Identities = 146/509 (28%), Positives = 240/509 (47%), Gaps = 35/509 (6%)
Query: 4 RAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYED 63
RAKA + A+P A G R R++ E +PR R+ L + QGY
Sbjct: 26 RAKAAIPAALPSDKATGAPGAGPGVRRRQRSL---EEIPRLGQLRFFFQLFV---QGYA- 78
Query: 64 LHLEVHQTF----QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY 119
L++HQ + GP++ LG V + +E++ + + +P R +E W +
Sbjct: 79 --LQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEH 136
Query: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 179
R G F G W R LN +L P + + V DF L + ++
Sbjct: 137 RDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAES 196
Query: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239
A G+ D+ +++ +EA LF +R+G + S ++ F+ ++ +MF++++ F
Sbjct: 197 ASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATF 256
Query: 240 MPRSLSRWTSPKV--WKEHFEAWDCIFQYG----DNCIQKIYQELAFSRPQ--QYTSIVA 291
+P+ WT P + WK + + W+ IF +G D ++ + +L + P Q + +
Sbjct: 257 LPK----WTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLH 312
Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
LL + +LSP + EL VDTT L L+ L+++P +Q+AL +E + +
Sbjct: 313 FLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAG 372
Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411
K +PLL+A LKETLRLYPV R+ ++ + + P T Y +
Sbjct: 373 QVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVS 432
Query: 412 RNPALFPRPERYNPQRWLDIRGS-------GRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464
R+P F PE + P RWL R S F VPFG+G+R CLGRR+AE EM LLL
Sbjct: 433 RDPTAFSEPESFQPHRWL--RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLL 490
Query: 465 HHVLKHLQVETLTQE-DIKMVYSFILRPS 492
+++ +V + ++K V +L P+
Sbjct: 491 ARLIQKYKVVLAPETGELKSVARIVLVPN 519
>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
[Homo sapiens]
Length = 372
Score = 166 bits (419), Expect = 6e-41
Identities = 110/344 (31%), Positives = 174/344 (50%), Gaps = 11/344 (3%)
Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203
L +L P V + V+ V D + + Q G +V F Y++E
Sbjct: 5 LRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATI 64
Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP---KVWKEHFEAW 260
L+ RLG + +S ++ ++ ALE+MF M+ ++ RW P K W+E +W
Sbjct: 65 LYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAG-AIPRWLRPFIPKPWREFCRSW 123
Query: 261 DCIFQYG----DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV 316
D +F++ DN ++ I ++ R + ++ L L+ L+ I AN E+ V
Sbjct: 124 DGLFKFSQIHVDNKLRDIQYQMDRGR-RVSGGLLTYLFLSQALTLQEIYANVTEMLLAGV 182
Query: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376
DTT F L T++ LAR+P VQQ + +E + ++PL+RA LKETLRL+
Sbjct: 183 DTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLF 242
Query: 377 PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR 436
PV RV DLV+ Y IP GT + + Y+ FPR + + P+RWL R
Sbjct: 243 PVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDR 302
Query: 437 --NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ 478
NF +PFG G+R C+GRR+AE E+ L++ +L+H +++T +Q
Sbjct: 303 VDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQ 346
>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
isoform 2 precursor [Homo sapiens]
Length = 448
Score = 151 bits (382), Expect = 1e-36
Identities = 104/380 (27%), Positives = 179/380 (47%), Gaps = 6/380 (1%)
Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111
LLQI + G + H + + ++ G IFR LG V + P +E L + +S +P R+
Sbjct: 70 LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
++PW AYR +R G+ +L G +W+ R +++ P V + ++ V DF
Sbjct: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231
+ + L + RG + D+ + ++ E+ L L+ +R GL+ + ++NF+ A++ M
Sbjct: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291
+ ++M P L + + KVW++H AWD IF+ CI ++ + Q +
Sbjct: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351
++ LS + A EL +V+TT L+ L+ L+RNP VQQ L +E +
Sbjct: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411
+ +P L+A LKE++RL P F R VL Y +P G + + + +
Sbjct: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATD 423
Query: 412 RNPALFPRPERYNPQRWLDI 431
P P R L I
Sbjct: 424 NEPVEMLHSGTLVPSRELPI 443
>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
[Homo sapiens]
Length = 525
Score = 103 bits (256), Expect = 5e-22
Identities = 110/446 (24%), Positives = 191/446 (42%), Gaps = 53/446 (11%)
Query: 77 PIFRYDLGGAGMVCVMLPEDVEKL----QQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 132
P+ + +G MV + E+VE + +Q+D ++ LEPW+ G+
Sbjct: 88 PLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKF-LEPWLGL--------GLLTS 138
Query: 133 NGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 192
G +WR R L P ++ FL +++ A + L+K + Q A
Sbjct: 139 TGNKWRSRRKMLTP-TFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCF-------- 189
Query: 193 FHYTIEASNL---ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249
F+ T+ A ++ G+ +G + S E++F+ +++ ++ L
Sbjct: 190 FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRR-IKMPWLWLDLWYLMF 248
Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRP-----------QQYTSIVAELLLNA- 297
+ W EH ++ + + ++ I + E+ + + +LLL+
Sbjct: 249 KEGW-EHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVT 307
Query: 298 -----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASIS 352
LS + I+ DTT + +L+ L NP VQ+ + E L S
Sbjct: 308 DDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHE-LDDVFGKS 366
Query: 353 EHPQKATTE----LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY 408
+ P AT E L L +KETLRL+P R S D + Y + GT + Y
Sbjct: 367 DRP--ATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPY 424
Query: 409 SLGRNPALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHV 467
+L R+P FP PE + P+R+ GR+ Y +VPF G R C+G++ A E +L +
Sbjct: 425 ALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCI 484
Query: 468 LKHLQVET-LTQEDIKMVYSFILRPS 492
L+H +E+ +E++ + ILRPS
Sbjct: 485 LRHFWIESNQKREELGLEGQLILRPS 510
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 101 bits (251), Expect = 2e-21
Identities = 63/195 (32%), Positives = 100/195 (51%), Gaps = 2/195 (1%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
LS + A S+ +TT L TL+ELA +P+VQQ L++E A + + A
Sbjct: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349
Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 418
++ L + ETLRL+PV + LER D+ + IP G++V + Y+L +P +
Sbjct: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 409
Query: 419 RPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL-- 476
PE + P+R+ + S + + PFG G R C+G R A M L L VL++ +
Sbjct: 410 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 469
Query: 477 TQEDIKMVYSFILRP 491
TQ +K+ +L+P
Sbjct: 470 TQIPLKLDTQGLLQP 484
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 97.4 bits (241), Expect = 3e-20
Identities = 104/453 (22%), Positives = 199/453 (43%), Gaps = 42/453 (9%)
Query: 59 QGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPW 116
+G + E ++ + E+ ++ G M+ +M P+ ++ + ++ S+ ++M L P
Sbjct: 55 RGLWNFDRECNEKYGEMWGLYE---GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPM 111
Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176
K + EW+ R L+P S +F MV +++ L + +
Sbjct: 112 GFL------KSALSFAEDEEWKRIRTLLSPAFTSV----KFKEMVPIISQ-CGDMLVRSL 160
Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236
Q A S +++++ YT++ LFG L + + N L++ F
Sbjct: 161 RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL 220
Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDC------IFQYGDNCIQKIYQELAFSRPQQYTSIV 290
L+ SL + +P FEA + + + N I+++ + + +
Sbjct: 221 LLI---SLFPFLTPV-----FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272
Query: 291 AELL--LNAELSPDAIKANSMELTAGSV-------DTTVFPLLMTLFELARNPNVQQALR 341
+++ N++ + + +EL A S+ DTT L ++ELA +P+VQQ L+
Sbjct: 273 QQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGT 401
+E A + + A ++ L + ETLRL+PV + RV D+ + IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL 392
Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEM 460
V V +Y+L +P + PE++ P+R+ + Y ++PFG G R C+G R A +
Sbjct: 393 AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNI 452
Query: 461 LLLLHHVLKHLQVETL--TQEDIKMVYSFILRP 491
L + L++ + TQ +K+ IL+P
Sbjct: 453 KLAVIRALQNFSFKPCKETQIPLKLDNLPILQP 485
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 94.7 bits (234), Expect = 2e-19
Identities = 61/196 (31%), Positives = 99/196 (50%), Gaps = 3/196 (1%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
LS + A S+ +TT L ++ELA +P+VQQ L++E A + +
Sbjct: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349
Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 418
++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+L R+P +
Sbjct: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409
Query: 419 RPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL- 476
PE++ P+R+ + Y + PFG G R C+G R A M L L VL++ +
Sbjct: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 469
Query: 477 -TQEDIKMVYSFILRP 491
TQ +K+ +L+P
Sbjct: 470 ETQIPLKLSLGGLLQP 485
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 93.2 bits (230), Expect = 5e-19
Identities = 105/458 (22%), Positives = 200/458 (43%), Gaps = 51/458 (11%)
Query: 59 QGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPW 116
+G + E ++ + E+ ++ G M+ +M P+ ++ + ++ S+ ++M L P
Sbjct: 55 RGLWNFDRECNEKYGEMWGLYE---GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPM 111
Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176
K + EW+ R L+P S +F MV +++ L + +
Sbjct: 112 GFL------KSALSFAEDEEWKRIRTLLSPAFTSV----KFKEMVPIISQ-CGDMLVRSL 160
Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236
Q A S +++++ YT++ LFG L + + N L++ F
Sbjct: 161 RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL 220
Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDC------IFQYGDNCIQKIYQELAFSRPQQYTSIV 290
L+ SL + +P FEA + + + N I+++ + + +
Sbjct: 221 LLI---SLFPFLTPV-----FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272
Query: 291 AELL--LNAELSPDAIKANSMELTAGSV-------DTTVFPLLMTLFELARNPNVQQALR 341
+++ N++ + + +EL A S+ DTT L ++ELA +P+VQQ L+
Sbjct: 273 QQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGT 401
+E A + + A ++ L + ETLRL+PV + RV D+ + IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL 392
Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN------FYHVPFGFGMRQCLGRRL 455
V V +Y+L +P + PE++ P+ R S +N + ++PFG G R C+G R
Sbjct: 393 AVMVPIYALHHDPKYWTEPEKFCPES----RFSKKNKDSIDLYRYIPFGAGPRNCIGMRF 448
Query: 456 AEAEMLLLLHHVLKHLQVETL--TQEDIKMVYSFILRP 491
A + L + L++ + TQ +K+ IL+P
Sbjct: 449 ALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQP 486
>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
[Homo sapiens]
Length = 524
Score = 90.9 bits (224), Expect = 2e-18
Identities = 60/178 (33%), Positives = 89/178 (50%), Gaps = 4/178 (2%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHPQ 356
LS + I+A + G DTT L L+ LAR+P Q+ RQE L E
Sbjct: 313 LSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEW 372
Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGTLVRVFLYSLGRNPA 415
+LP L +KE+LRL+P F+ R + D+VL + IP G + + + NP
Sbjct: 373 DDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432
Query: 416 LFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472
++P PE Y+P R+ GR+ +PF G R C+G+ A AEM ++L +L H +
Sbjct: 433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 490
>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
[Homo sapiens]
Length = 520
Score = 89.7 bits (221), Expect = 5e-18
Identities = 96/380 (25%), Positives = 161/380 (42%), Gaps = 33/380 (8%)
Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171
+L+PW+ G+ L G +WR +R L P N ++ ++ + A
Sbjct: 127 TLKPWLGD--------GLLLSVGDKWRHHRRLLTP-AFHFNILKPYIKIFSKSANIMHAK 177
Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231
++ ++ GS LDV I T+++ +F PS + ++
Sbjct: 178 WQRLAME---GSTCLDVFEHISLMTLDSLQKCIFSFDSNCQ-EKPSEYITAIMELSALVV 233
Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291
K Q F + + +P + H A + + D IQ+ + L + A
Sbjct: 234 KRNNQF-FRYKDFLYFLTPCGRRFH-RACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKA 291
Query: 292 E---------LLLNA-----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQ 337
+ LLL+ ELS + I+A + G DTT L L+ LAR+P Q
Sbjct: 292 KSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351
Query: 338 QALRQE--SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395
+ RQE L E +LP L LKE+LRL+P R + D+VL +
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411
Query: 396 H-IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGR 453
IP G + + ++++ NP+++P PE Y+P R+ R+ +PF G R C+G+
Sbjct: 412 RVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQ 471
Query: 454 RLAEAEMLLLLHHVLKHLQV 473
+ A AEM ++L L ++
Sbjct: 472 KFAMAEMKVVLALTLLRFRI 491
>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
[Homo sapiens]
Length = 503
Score = 89.4 bits (220), Expect = 7e-18
Identities = 57/190 (30%), Positives = 91/190 (47%), Gaps = 1/190 (0%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
LS + A S+ +TT L ++ELA +P+VQQ +++E + +
Sbjct: 290 LSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDT 349
Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 418
+L L + ETLRL+PV + LERV D+ + IP G +V + Y L +P +
Sbjct: 350 VLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWT 409
Query: 419 RPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLT 477
PE++ P+R+ + Y + PFG G R C+G R A M L L VL++ +
Sbjct: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCK 469
Query: 478 QEDIKMVYSF 487
+ I + F
Sbjct: 470 ETQIPLKLRF 479
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 86.7 bits (213), Expect = 5e-17
Identities = 52/156 (33%), Positives = 83/156 (53%), Gaps = 2/156 (1%)
Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369
+L DTT LL L ++ NP+VQ+ + +E + ++P A +
Sbjct: 348 DLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATI 407
Query: 370 KETLRL-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428
E RL V L + + S + VLQ Y IP GTL+ L+S+ R+PA++ +PE + P R+
Sbjct: 408 MEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRF 467
Query: 429 LDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463
LD +G + +PFG G R C+G +LA+ E+ L+
Sbjct: 468 LDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLM 503
>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 82.4 bits (202), Expect = 9e-16
Identities = 56/188 (29%), Positives = 89/188 (47%), Gaps = 4/188 (2%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
L+ D I + + L + LA NP+ Q+ L +E + P+
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE-VDVFKEKHMAPEFC 385
Query: 359 TTE--LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416
+ E LP L + ETLR+YP R A+ D + IPAG ++ + + +L +P
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
Query: 417 FPRPERYNPQRW-LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET 475
+P PE +NP+R+ + R R F ++PFG G R CLG RL E+ L L HVL + +
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
Query: 476 LTQEDIKM 483
+ + +
Sbjct: 506 CPETQVPL 513
>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
sapiens]
Length = 534
Score = 82.4 bits (202), Expect = 9e-16
Identities = 56/188 (29%), Positives = 89/188 (47%), Gaps = 4/188 (2%)
Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358
L+ D I + + L + LA NP+ Q+ L +E + P+
Sbjct: 327 LTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE-VDVFKEKHMAPEFC 385
Query: 359 TTE--LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416
+ E LP L + ETLR+YP R A+ D + IPAG ++ + + +L +P
Sbjct: 386 SLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEH 445
Query: 417 FPRPERYNPQRW-LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET 475
+P PE +NP+R+ + R R F ++PFG G R CLG RL E+ L L HVL + +
Sbjct: 446 WPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQA 505
Query: 476 LTQEDIKM 483
+ + +
Sbjct: 506 CPETQVPL 513
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 81.3 bits (199), Expect = 2e-15
Identities = 111/454 (24%), Positives = 182/454 (40%), Gaps = 46/454 (10%)
Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEK--LQQVDSLHPHRMSLEPWVAYRQH 122
H+ + + Q G IF DLGG V V+ DV K L + R L ++ +
Sbjct: 63 HVYMRKQSQVYGEIFSLDLGGISTV-VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 121
Query: 123 RGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALK--KKVLQNA 180
G LLN R+ R ++ L+ N+ + F + + K ++
Sbjct: 122 GG------LLNS---RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 172
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL--- 237
+G D + I + +NL +FGER + +F H +E +F V+L
Sbjct: 173 KGR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAAS 223
Query: 238 --MFMPRSLSRWTSPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAE 292
+F+ + W + +H F ++ + I+K PQ + +
Sbjct: 224 ASVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLD 282
Query: 293 LLLNAELSPDAI--KANSM----ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA 346
+ + P + K N + EL +TT L + +A PN+Q +++E
Sbjct: 283 EMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDL 342
Query: 347 AAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLV 403
+ ++P A L E LR + P+G+F S D V++ Y IP GT V
Sbjct: 343 IMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF--HATSEDAVVRGYSIPKGTTV 400
Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRG-SGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462
LYS+ + + PE ++P+R+LD G + VPF G R CLG LA EM L
Sbjct: 401 ITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFL 460
Query: 463 LLHHVLK--HLQVETLTQEDIKMVYSFILRPSMF 494
+L+ HL D+K L+P +
Sbjct: 461 FFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPY 494
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 80.5 bits (197), Expect = 3e-15
Identities = 55/166 (33%), Positives = 82/166 (49%), Gaps = 7/166 (4%)
Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE---SLAAAASISEHPQKATTELPL 364
+++L G +TT L + L +P +QQ L++E L AS S P K LPL
Sbjct: 256 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 315
Query: 365 LRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423
L A + E LRL P V L L + + Y IP GT++ L + ++ RP +
Sbjct: 316 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 375
Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469
P R+L+ G+N + FG G R CLG LA E+ ++L +L+
Sbjct: 376 WPDRFLE---PGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQ 418
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 80.5 bits (197), Expect = 3e-15
Identities = 55/166 (33%), Positives = 82/166 (49%), Gaps = 7/166 (4%)
Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE---SLAAAASISEHPQKATTELPL 364
+++L G +TT L + L +P +QQ L++E L AS S P K LPL
Sbjct: 286 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 345
Query: 365 LRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423
L A + E LRL P V L L + + Y IP GT++ L + ++ RP +
Sbjct: 346 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469
P R+L+ G+N + FG G R CLG LA E+ ++L +L+
Sbjct: 406 WPDRFLE---PGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 80.5 bits (197), Expect = 3e-15
Identities = 57/180 (31%), Positives = 87/180 (48%), Gaps = 4/180 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
ELS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGTLVRVFLYSLGRNP 414
+LP L +KE+LRL+P + R + D VL + IP G + + + + NP
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNP 431
Query: 415 ALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
++P PE Y+P R+ R+ +PF G R C+G+ A AEM ++L L H ++
Sbjct: 432 TVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491
>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
[Homo sapiens]
Length = 524
Score = 80.5 bits (197), Expect = 3e-15
Identities = 57/180 (31%), Positives = 87/180 (48%), Gaps = 4/180 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
ELS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 ELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGTLVRVFLYSLGRNP 414
+LP L +KE+LRL+P + R + D VL + IP G + + + + NP
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNP 431
Query: 415 ALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
++P PE Y+P R+ R+ +PF G R C+G+ A AEM ++L L H ++
Sbjct: 432 TVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491
>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
[Homo sapiens]
Length = 520
Score = 79.7 bits (195), Expect = 6e-15
Identities = 57/180 (31%), Positives = 88/180 (48%), Gaps = 4/180 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
+LS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGTLVRVFLYSLGRNP 414
+LP L +KE+LRL+P + R + D+VL + IP G + + ++ NP
Sbjct: 372 WDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNP 431
Query: 415 ALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
A++P PE Y+P R+ R+ +PF G R C+G+ A AEM ++L L +V
Sbjct: 432 AVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRV 491
>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
[Homo sapiens]
Length = 520
Score = 79.0 bits (193), Expect = 1e-14
Identities = 57/180 (31%), Positives = 87/180 (48%), Gaps = 4/180 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
+LS + I+A + DTT L L+ LA++P Q+ RQE L E
Sbjct: 312 KLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIE 371
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH-IPAGTLVRVFLYSLGRNP 414
LP L +KE+LRL+P + R + D+VL + IP G + + ++ NP
Sbjct: 372 WDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNP 431
Query: 415 ALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
A++P PE Y+P R+ R+ +PF G R C+G+ A AEM ++L L +V
Sbjct: 432 AVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491
>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 3 [Homo sapiens]
Length = 420
Score = 78.2 bits (191), Expect = 2e-14
Identities = 86/386 (22%), Positives = 168/386 (43%), Gaps = 39/386 (10%)
Query: 59 QGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPW 116
+G + E ++ + E+ ++ G M+ +M P+ ++ + ++ S+ ++M L P
Sbjct: 55 RGLWNFDRECNEKYGEMWGLYE---GQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPM 111
Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176
K + EW+ R L+P S +F MV +++ L + +
Sbjct: 112 GFL------KSALSFAEDEEWKRIRTLLSPAFTSV----KFKEMVPIISQ-CGDMLVRSL 160
Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236
Q A S +++++ YT++ LFG L + + N L++ F
Sbjct: 161 RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL 220
Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDC------IFQYGDNCIQKIYQELAFSRPQQYTSIV 290
L+ SL + +P FEA + + + N I+++ + + +
Sbjct: 221 LLI---SLFPFLTPV-----FEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFF 272
Query: 291 AELL--LNAELSPDAIKANSMELTAGSV-------DTTVFPLLMTLFELARNPNVQQALR 341
+++ N++ + + +EL A S+ DTT L ++ELA +P+VQQ L+
Sbjct: 273 QQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQ 332
Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGT 401
+E A + + A ++ L + ETLRL+PV + RV D+ + IP G
Sbjct: 333 EEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL 392
Query: 402 LVRVFLYSLGRNPALFPRPERYNPQR 427
V V +Y+L +P + PE++ P+R
Sbjct: 393 AVMVPIYALHHDPKYWTEPEKFCPER 418
>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
[Homo sapiens]
Length = 531
Score = 77.8 bits (190), Expect = 2e-14
Identities = 56/197 (28%), Positives = 90/197 (45%), Gaps = 4/197 (2%)
Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE--SLAAAASISEHP 355
ELS + I+A + DTT + LF LA+ P Q+ R+E + + E
Sbjct: 319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELE 378
Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHI-PAGTLVRVFLYSLGRNP 414
T+LP +KE+LR YP + R + D+ L + I P G + V +Y NP
Sbjct: 379 WDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNP 438
Query: 415 ALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473
++P + YNP R+ R+ +VPF G R C+G+ A AE+ +++ L ++
Sbjct: 439 TVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498
Query: 474 ETLTQEDIKMVYSFILR 490
++ ILR
Sbjct: 499 SVDRTRKVRRKPELILR 515
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,619,795
Number of Sequences: 37866
Number of extensions: 821532
Number of successful extensions: 2553
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 2357
Number of HSP's gapped (non-prelim): 97
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.