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Search of human proteins with 6005850
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
(543 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 1092 0.0
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 1071 0.0
gi|22209009 protein kinase CHK2 isoform b [Homo sapiens] 1018 0.0
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 220 2e-57
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 219 7e-57
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 215 9e-56
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 215 9e-56
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 206 3e-53
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 194 2e-49
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 194 2e-49
gi|5031689 protein kinase D3 [Homo sapiens] 191 1e-48
gi|115529463 protein kinase D1 [Homo sapiens] 191 1e-48
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 188 1e-47
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 186 5e-47
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 186 5e-47
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 186 5e-47
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 186 5e-47
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 184 2e-46
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 184 2e-46
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 184 2e-46
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 184 2e-46
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 184 2e-46
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 184 2e-46
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 181 2e-45
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 181 2e-45
gi|27901803 protein serine kinase H1 [Homo sapiens] 180 3e-45
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 180 3e-45
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 179 8e-45
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 179 8e-45
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 179 8e-45
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 1092 bits (2824), Expect = 0.0
Identities = 543/543 (100%), Positives = 543/543 (100%)
Query: 1 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
Sbjct: 1 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
Query: 61 SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
Sbjct: 61 SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120
Query: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
Sbjct: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180
Query: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
Sbjct: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240
Query: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
Sbjct: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300
Query: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
Sbjct: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
Query: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
Sbjct: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
Query: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
Sbjct: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
Query: 481 LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA 540
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
Sbjct: 481 LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA 540
Query: 541 AVL 543
AVL
Sbjct: 541 AVL 543
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 1071 bits (2770), Expect = 0.0
Identities = 543/586 (92%), Positives = 543/586 (92%), Gaps = 43/586 (7%)
Query: 1 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
Sbjct: 1 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
Query: 61 SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLE------------- 107
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLE
Sbjct: 61 SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGHVTQSDLEL 120
Query: 108 ------------------------------CVNDNYWFGRDKSCEYCFDEPLLKRTDKYR 137
CVNDNYWFGRDKSCEYCFDEPLLKRTDKYR
Sbjct: 121 LLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYCFDEPLLKRTDKYR 180
Query: 138 TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK 197
TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK
Sbjct: 181 TYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNK 240
Query: 198 VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA 257
VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA
Sbjct: 241 VFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA 300
Query: 258 IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK 317
IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK
Sbjct: 301 IGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK 360
Query: 318 RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE 377
RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE
Sbjct: 361 RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE 420
Query: 378 TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK 437
TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK
Sbjct: 421 TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLK 480
Query: 438 DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD 497
DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD
Sbjct: 481 DQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQD 540
Query: 498 LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL 543
LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Sbjct: 541 LLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL 586
>gi|22209009 protein kinase CHK2 isoform b [Homo sapiens]
Length = 514
Score = 1018 bits (2631), Expect = 0.0
Identities = 514/543 (94%), Positives = 514/543 (94%), Gaps = 29/543 (5%)
Query: 1 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
Sbjct: 1 MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL 60
Query: 61 SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
Sbjct: 61 SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS 120
Query: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
Sbjct: 121 CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR 180
Query: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
Sbjct: 181 RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER 240
Query: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
Sbjct: 241 KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV 300
Query: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ
Sbjct: 301 LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ------------------------ 336
Query: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
ITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
Sbjct: 337 -----ITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 391
Query: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
Sbjct: 392 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 451
Query: 481 LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA 540
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
Sbjct: 452 LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA 511
Query: 541 AVL 543
AVL
Sbjct: 512 AVL 514
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 220 bits (561), Expect = 2e-57
Identities = 127/284 (44%), Positives = 173/284 (60%), Gaps = 17/284 (5%)
Query: 207 DDQSVYPKA---LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSARE 263
DD S + K +R +I + LGSGA EV L +R T K A+K I K S
Sbjct: 7 DDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK------SPAF 60
Query: 264 ADPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEA 322
D +L E EI +LKK+ H I+ +++ +++ YY+V++L+ GGELFD+++ E
Sbjct: 61 RDSSL--ENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEK 118
Query: 323 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMR 382
L Q+L AV+YLHENGI+HRDLKPEN+L + EE+ I ITDFG SK + + +M
Sbjct: 119 DASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMS 177
Query: 383 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 442
T CGTP Y+APEVL Y++AVDCWS+GVI +I L GYPPF E T+ L ++I
Sbjct: 178 TACGTPGYVAPEVLAQ---KPYSKAVDCWSIGVITYILLCGYPPFYE-ETESKLFEKIKE 233
Query: 443 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
G Y F W ++SE A D + LL DP R+T E+AL HPW+
Sbjct: 234 GYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 219 bits (557), Expect = 7e-57
Identities = 119/289 (41%), Positives = 177/289 (61%), Gaps = 13/289 (4%)
Query: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
+RD Y LG+GA EV LA +++T K VAIK I+K +E ++E EI
Sbjct: 16 IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL---EGKEG----SMENEIA 68
Query: 276 ILKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLA 334
+L K+ HP I+ + + +++ + Y++++L+ GGELFD++V E +Q+L A
Sbjct: 69 VLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDA 128
Query: 335 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPE 394
V+YLH+ GI+HRDLKPEN+L S +ED I I+DFG SK+ S++ T CGTP Y+APE
Sbjct: 129 VKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPE 188
Query: 395 VLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAE 454
VL Y++AVDCWS+GVI +I L GYPPF + L +QI +Y F W +
Sbjct: 189 VLAQ---KPYSKAVDCWSIGVIAYILLCGYPPFYD-ENDAKLFEQILKAEYEFDSPYWDD 244
Query: 455 VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQ-DEDMKRKFQDLLSEE 502
+S+ A D ++ L+ DP+ RFT E+AL+HPW+ D + + +SE+
Sbjct: 245 ISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQ 293
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 215 bits (547), Expect = 9e-56
Identities = 114/272 (41%), Positives = 168/272 (61%), Gaps = 12/272 (4%)
Query: 224 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 283
+TLG+GA EV LA E+ T K A+K I K+ +E+ ++E EI +L+K+ H
Sbjct: 27 ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL---KGKES----SIENEIAVLRKIKHE 79
Query: 284 CIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENG 342
I+ +++ +++ ++ Y+V++L+ GGELFD++V E Q+L AV YLH G
Sbjct: 80 NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 343 IIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTA 402
I+HRDLKPEN+L SQ+E+ I I+DFG SK+ G+ +M T CGTP Y+APEVL
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ---K 196
Query: 403 GYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDL 462
Y++AVDCWS+GVI +I L GYPPF + L +QI +Y F W ++S+ A D
Sbjct: 197 PYSKAVDCWSIGVIAYILLCGYPPFYDENDS-KLFEQILKAEYEFDSPYWDDISDSAKDF 255
Query: 463 VKKLLVVDPKARFTTEEALRHPWLQDEDMKRK 494
++ L+ DP R+T E+A RHPW+ + K
Sbjct: 256 IRNLMEKDPNKRYTCEQAARHPWIAGDTALNK 287
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 215 bits (547), Expect = 9e-56
Identities = 114/272 (41%), Positives = 168/272 (61%), Gaps = 12/272 (4%)
Query: 224 KTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHP 283
+TLG+GA EV LA E+ T K A+K I K+ +E+ ++E EI +L+K+ H
Sbjct: 27 ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL---KGKES----SIENEIAVLRKIKHE 79
Query: 284 CIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENG 342
I+ +++ +++ ++ Y+V++L+ GGELFD++V E Q+L AV YLH G
Sbjct: 80 NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 343 IIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTA 402
I+HRDLKPEN+L SQ+E+ I I+DFG SK+ G+ +M T CGTP Y+APEVL
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ---K 196
Query: 403 GYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDL 462
Y++AVDCWS+GVI +I L GYPPF + L +QI +Y F W ++S+ A D
Sbjct: 197 PYSKAVDCWSIGVIAYILLCGYPPFYDENDS-KLFEQILKAEYEFDSPYWDDISDSAKDF 255
Query: 463 VKKLLVVDPKARFTTEEALRHPWLQDEDMKRK 494
++ L+ DP R+T E+A RHPW+ + K
Sbjct: 256 IRNLMEKDPNKRYTCEQAARHPWIAGDTALNK 287
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 206 bits (525), Expect = 3e-53
Identities = 126/330 (38%), Positives = 178/330 (53%), Gaps = 22/330 (6%)
Query: 215 ALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEI 274
AL D + + LG GA V ++ T K A+K++ K D + V TEI
Sbjct: 41 ALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT---------VDKKI-VRTEI 90
Query: 275 EILKKLNHPCIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLL 333
+L +L+HP IIK+K F+ + +VLEL+ GGELFD++V E Q+L
Sbjct: 91 GVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILE 150
Query: 334 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 393
AV YLHENGI+HRDLKPEN+L ++ D +KI DFG SKI+ LM+T+CGTP Y AP
Sbjct: 151 AVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAP 210
Query: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 453
E+L Y VD WS+G+I +I L G+ PF + R + +I + +Y FI W
Sbjct: 211 EILRG---CAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267
Query: 454 EVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD--------EDMKRKFQDLLSEENES 505
EVS A DLV+KL+V+DPK R TT +AL+HPW+ + ++K Q+ +
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLK 327
Query: 506 TALPQVLAQPSTSRKRPREGEAEGAETTKR 535
A+ V+A G + + R
Sbjct: 328 AAVKAVVASSRLGSASSSHGSIQESHKASR 357
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 194 bits (493), Expect = 2e-49
Identities = 113/271 (41%), Positives = 162/271 (59%), Gaps = 13/271 (4%)
Query: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279
Y + + LGSGA EV LA ER + VA+K I K+ A AL VE EI +L++
Sbjct: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKK------ALRGKEAL-VENEIAVLRR 84
Query: 280 LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL 338
++HP I+ +++ ++ + Y+ +EL+ GGELFD+++ E Q+L AV YL
Sbjct: 85 ISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYL 144
Query: 339 HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS 398
H GI+HRDLKPEN+L ++ ED I ++DFG SKI +++ T CGTP Y+APE+L
Sbjct: 145 HSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPELLEQ 203
Query: 399 VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK 458
Y +AVD W+LGVI +I L GYPPF + + L QI Y F W ++SE
Sbjct: 204 ---KPYGKAVDVWALGVISYILLCGYPPFYD-ESDPELFSQILRASYEFDSPFWDDISES 259
Query: 459 ALDLVKKLLVVDPKARFTTEEALRHPWLQDE 489
A D ++ LL DP+ RFT ++ALRH W+ +
Sbjct: 260 AKDFIRHLLERDPQKRFTCQQALRHLWISGD 290
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 194 bits (493), Expect = 2e-49
Identities = 113/271 (41%), Positives = 162/271 (59%), Gaps = 13/271 (4%)
Query: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279
Y + + LGSGA EV LA ER + VA+K I K+ A AL VE EI +L++
Sbjct: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKK------ALRGKEAL-VENEIAVLRR 150
Query: 280 LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL 338
++HP I+ +++ ++ + Y+ +EL+ GGELFD+++ E Q+L AV YL
Sbjct: 151 ISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYL 210
Query: 339 HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS 398
H GI+HRDLKPEN+L ++ ED I ++DFG SKI +++ T CGTP Y+APE+L
Sbjct: 211 HSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPELLEQ 269
Query: 399 VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK 458
Y +AVD W+LGVI +I L GYPPF + + L QI Y F W ++SE
Sbjct: 270 ---KPYGKAVDVWALGVISYILLCGYPPFYD-ESDPELFSQILRASYEFDSPFWDDISES 325
Query: 459 ALDLVKKLLVVDPKARFTTEEALRHPWLQDE 489
A D ++ LL DP+ RFT ++ALRH W+ +
Sbjct: 326 AKDFIRHLLERDPQKRFTCQQALRHLWISGD 356
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 191 bits (486), Expect = 1e-48
Identities = 111/286 (38%), Positives = 171/286 (59%), Gaps = 22/286 (7%)
Query: 206 VDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREAD 265
VD +VY + + LGSG G V RKT + VAIK+I K +F +
Sbjct: 568 VDISTVY------QIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQ-- 619
Query: 266 PALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNK--RLKEA 322
+ E+ IL+ L+HP I+ ++ F+ E ++V+E + G ++ + ++ ++ RL E
Sbjct: 620 ----LRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKSRLPER 674
Query: 323 TCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMR 382
K Q+L+A++ LH I+H DLKPENVLL+S E +K+ DFG ++I+GE S R
Sbjct: 675 ITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRR 734
Query: 383 TLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITS 442
++ GTP YLAPEVL S GYNR++D WS+GVI+++ LSG PF+E + DQI +
Sbjct: 735 SVVGTPAYLAPEVLRS---KGYNRSLDMWSVGVIIYVSLSGTFPFNEDE---DINDQIQN 788
Query: 443 GKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 488
+ + P W E+S +A+DL+ LL V + R++ +++L HPWLQD
Sbjct: 789 AAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD 834
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 191 bits (485), Expect = 1e-48
Identities = 115/317 (36%), Positives = 184/317 (58%), Gaps = 28/317 (8%)
Query: 175 VGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEV 234
VG G L+ + +++S+S ++ VD +VY + + LGSG G V
Sbjct: 550 VGTGTN--LHRDISVSISVSNCQI----QENVDISTVY------QIFPDEVLGSGQFGIV 597
Query: 235 KLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA 294
RKT + VAIKII K +F + + E+ IL+ L+HP ++ ++ F+
Sbjct: 598 YGGKHRKTGRDVAIKIIDKLRFPTKQESQ------LRNEVAILQNLHHPGVVNLECMFET 651
Query: 295 -EDYYIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPE 351
E ++V+E + G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPE
Sbjct: 652 PERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPE 710
Query: 352 NVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCW 411
NVLL+S + +K+ DFG ++I+GE S R++ GTP YLAPEVL GYNR++D W
Sbjct: 711 NVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL---RNKGYNRSLDMW 767
Query: 412 SLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 471
S+GVI+++ LSG PF+E + DQI + + + P W E+S +A+DL+ LL V
Sbjct: 768 SVGVIIYVSLSGTFPFNEDE---DIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKM 824
Query: 472 KARFTTEEALRHPWLQD 488
+ R++ ++ L HPWLQD
Sbjct: 825 RKRYSVDKTLSHPWLQD 841
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 188 bits (477), Expect = 1e-47
Identities = 103/271 (38%), Positives = 160/271 (59%), Gaps = 15/271 (5%)
Query: 220 YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKK 279
Y + +G G VK R+T + A+KII K + +E V++EI I++
Sbjct: 356 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRL---KGKED----MVDSEILIIQS 408
Query: 280 LNHPCIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL 338
L+HP I+K+ ++ + + Y++LE ++GG+LFD ++ + + E L + A+ ++
Sbjct: 409 LSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHM 468
Query: 339 HENGIIHRDLKPENVLLSSQEE-DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLV 397
H+ I+HRDLKPEN+L+ E+ +K+ DFG +K + T+CGTPTY+APE+L
Sbjct: 469 HDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF--TVCGTPTYVAPEIL- 525
Query: 398 SVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIPEVWAEVS 456
GY VD W+ GVIL+I L G+PPF S R Q L + I G + F+P W +S
Sbjct: 526 --SEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNIS 583
Query: 457 EKALDLVKKLLVVDPKARFTTEEALRHPWLQ 487
+ A DLV +LLVVDPK R+T + L+HPW++
Sbjct: 584 DAAKDLVSRLLVVDPKKRYTAHQVLQHPWIE 614
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 186 bits (472), Expect = 5e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 368 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 417
Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 418 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 471
Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 472 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 530
Query: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 531 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 587
Query: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 588 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 644
Query: 481 LRHPWLQD 488
L HPWLQ+
Sbjct: 645 LSHPWLQE 652
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 186 bits (472), Expect = 5e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574
Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628
Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687
Query: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744
Query: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801
Query: 481 LRHPWLQD 488
L HPWLQ+
Sbjct: 802 LSHPWLQE 809
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 186 bits (472), Expect = 5e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574
Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628
Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687
Query: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744
Query: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801
Query: 481 LRHPWLQD 488
L HPWLQ+
Sbjct: 802 LSHPWLQE 809
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 186 bits (472), Expect = 5e-47
Identities = 107/308 (34%), Positives = 181/308 (58%), Gaps = 26/308 (8%)
Query: 184 NNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTC 243
+ + +++S+S +++ VD +VY + + LGSG G V RKT
Sbjct: 525 HRQASLSISVSNSQI----QENVDIATVY------QIFPDEVLGSGQFGVVYGGKHRKTG 574
Query: 244 KKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA-EDYYIVLE 302
+ VA+K+I K +F + + E+ IL+ L HP I+ ++ F+ E ++V+E
Sbjct: 575 RDVAVKVIDKLRFPTKQESQ------LRNEVAILQSLRHPGIVNLECMFETPEKVFVVME 628
Query: 303 LMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE 360
+ G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPENVLL+S +
Sbjct: 629 KLHG-DMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP 687
Query: 361 DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC 420
+K+ DFG ++I+GE S R++ GTP YLAPEVL++ GYNR++D WS+GVI+++
Sbjct: 688 FPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVS 744
Query: 421 LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA 480
LSG PF+E + DQI + + + W+ +S A+DL+ LL V + R++ +++
Sbjct: 745 LSGTFPFNEDE---DINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKS 801
Query: 481 LRHPWLQD 488
L HPWLQ+
Sbjct: 802 LSHPWLQE 809
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 184 bits (466), Expect = 2e-46
Identities = 106/271 (39%), Positives = 157/271 (57%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
DEY + + LG GA V+ + T ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
+ H NGI+HRDLKPEN+LL+S+ + +K+ DFG + ++ G+ GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A DL+ K+L ++P R T EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 184 bits (466), Expect = 2e-46
Identities = 106/271 (39%), Positives = 157/271 (57%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
DEY + + LG GA V+ + T ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
+ H NGI+HRDLKPEN+LL+S+ + +K+ DFG + ++ G+ GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A DL+ K+L ++P R T EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 184 bits (466), Expect = 2e-46
Identities = 106/271 (39%), Positives = 157/271 (57%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
DEY + + LG GA V+ + T ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
+ H NGI+HRDLKPEN+LL+S+ + +K+ DFG + ++ G+ GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A DL+ K+L ++P R T EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 184 bits (466), Expect = 2e-46
Identities = 106/271 (39%), Positives = 157/271 (57%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
DEY + + LG GA V+ + T ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
+ H NGI+HRDLKPEN+LL+S+ + +K+ DFG + ++ G+ GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A DL+ K+L ++P R T EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 184 bits (466), Expect = 2e-46
Identities = 106/271 (39%), Positives = 157/271 (57%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
DEY + + LG GA V+ + T ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
+ H NGI+HRDLKPEN+LL+S+ + +K+ DFG + ++ G+ GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A DL+ K+L ++P R T EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 184 bits (466), Expect = 2e-46
Identities = 106/271 (39%), Positives = 157/271 (57%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
DEY + + LG GA V+ + T ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
+ H NGI+HRDLKPEN+LL+S+ + +K+ DFG + ++ G+ GTP YL+PEV
Sbjct: 126 HCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDMWACGVILYILLVGYPPFWD-EDQHRLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A DL+ K+L ++P R T EAL+HPW+
Sbjct: 242 TPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 181 bits (459), Expect = 2e-45
Identities = 106/321 (33%), Positives = 175/321 (54%), Gaps = 28/321 (8%)
Query: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
L ++Y + K +G G VK +R T K+ A+KII K K G +E E+
Sbjct: 389 LLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK-CCGKEHL------IENEVS 441
Query: 276 ILKKLNHPCIIK-IKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLA 334
IL+++ HP II ++ A + ++V+EL++GG+LFD + + + E Y + A
Sbjct: 442 ILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANA 501
Query: 335 VQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLMRTLCGTPTYLAP 393
++YLH I+HRD+KPEN+L+ + +K+ DFG + ++ + T+CGTPTY+AP
Sbjct: 502 LRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV--EGPLYTVCGTPTYVAP 559
Query: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIPEVW 452
E+ + GY VD W+ GVI +I L G+PPF SE+ Q L DQI +GK F W
Sbjct: 560 EI---IAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYW 616
Query: 453 AEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE-------------DMKRKFQDLL 499
+++ A +L+ ++L V+ +AR T + L HPW+ D+ +K+ F + L
Sbjct: 617 DNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNAL 676
Query: 500 SEENESTALPQVLAQPSTSRK 520
++N +T V+ + ++
Sbjct: 677 PKQNSTTTGVSVIMNTALDKE 697
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 181 bits (459), Expect = 2e-45
Identities = 106/321 (33%), Positives = 175/321 (54%), Gaps = 28/321 (8%)
Query: 216 LRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIE 275
L ++Y + K +G G VK +R T K+ A+KII K K G +E E+
Sbjct: 390 LLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK-CCGKEHL------IENEVS 442
Query: 276 ILKKLNHPCIIK-IKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLA 334
IL+++ HP II ++ A + ++V+EL++GG+LFD + + + E Y + A
Sbjct: 443 ILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANA 502
Query: 335 VQYLHENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKILGETSLMRTLCGTPTYLAP 393
++YLH I+HRD+KPEN+L+ + +K+ DFG + ++ + T+CGTPTY+AP
Sbjct: 503 LRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVV--EGPLYTVCGTPTYVAP 560
Query: 394 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIPEVW 452
E+ + GY VD W+ GVI +I L G+PPF SE+ Q L DQI +GK F W
Sbjct: 561 EI---IAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYW 617
Query: 453 AEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE-------------DMKRKFQDLL 499
+++ A +L+ ++L V+ +AR T + L HPW+ D+ +K+ F + L
Sbjct: 618 DNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNAL 677
Query: 500 SEENESTALPQVLAQPSTSRK 520
++N +T V+ + ++
Sbjct: 678 PKQNSTTTGVSVIMNTALDKE 698
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 180 bits (457), Expect = 3e-45
Identities = 111/271 (40%), Positives = 153/271 (56%), Gaps = 15/271 (5%)
Query: 219 EYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILK 278
+Y + +G G+ V R T + AIK+I + K+ G RE E+E+ +L+
Sbjct: 97 KYDIKALIGRGSFSRVVRVEHRATRQPYAIKMI-ETKYREG--REV-----CESELRVLR 148
Query: 279 KLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQY 337
++ H II++ F+ ++ Y+V+EL GGELFD+++ E +L V+Y
Sbjct: 149 RVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRY 208
Query: 338 LHENGIIHRDLKPENVLLSSQEEDCLIKITDFG--HSKILGETSLMRTLCGTPTYLAPEV 395
LH GI HRDLKPEN+L D I ITDFG ++ G+ LM+T CGTP Y+APEV
Sbjct: 209 LHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEV 268
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
LV Y +VD W+LGVI +I LSG PF E + L QI GKY++ E W V
Sbjct: 269 LV---RKPYTNSVDMWALGVIAYILLSGTMPF-EDDNRTRLYRQILRGKYSYSGEPWPSV 324
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
S A D + +LL VDP AR T +ALRHPW+
Sbjct: 325 SNLAKDFIDRLLTVDPGARMTALQALRHPWV 355
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 180 bits (456), Expect = 3e-45
Identities = 100/282 (35%), Positives = 157/282 (55%), Gaps = 15/282 (5%)
Query: 213 PKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVET 272
P + + Y + +T+G G VK ER T ++ A+KII K K R + ++
Sbjct: 383 PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSK-----CRGKEHM--IQN 435
Query: 273 EIEILKKLNHPCIIKIKNFFDAE-DYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQM 331
E+ IL+++ HP I+ + D + Y+V+EL++GG+LFD + + E Y +
Sbjct: 436 EVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNL 495
Query: 332 LLAVQYLHENGIIHRDLKPENVLL-SSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 390
A++YLH I+HRD+KPEN+L+ Q+ +K+ DFG + I+ + T+CGTPTY
Sbjct: 496 ASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTY 553
Query: 391 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVSLKDQITSGKYNFIP 449
+APE+ + GY VD W+ GVI +I L G+PPF Q L DQI G+ +F
Sbjct: 554 VAPEI---IAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPS 610
Query: 450 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDM 491
W VS+ A +L+ +L+VD RF+ + L HPW+ D+ +
Sbjct: 611 PYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGL 652
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 179 bits (453), Expect = 8e-45
Identities = 100/271 (36%), Positives = 161/271 (59%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
D+Y + + LG GA V+ ++ + ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA +Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
++H++ I+HRDLKPEN+LL+S+ + +K+ DFG + ++ GE GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A +L+ ++L ++P R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 179 bits (453), Expect = 8e-45
Identities = 100/271 (36%), Positives = 161/271 (59%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
D+Y + + LG GA V+ ++ + ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA +Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
++H++ I+HRDLKPEN+LL+S+ + +K+ DFG + ++ GE GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A +L+ ++L ++P R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 179 bits (453), Expect = 8e-45
Identities = 100/271 (36%), Positives = 161/271 (59%), Gaps = 12/271 (4%)
Query: 218 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 277
D+Y + + LG GA V+ ++ + ++ A KII+ +K SAR+ +E E I
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKL---SARDHQ---KLEREARIC 65
Query: 278 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQ 336
+ L HP I+++ + E + Y+V +L+ GGELF+ +V + EA +Q+L +V
Sbjct: 66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125
Query: 337 YLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHS-KILGETSLMRTLCGTPTYLAPEV 395
++H++ I+HRDLKPEN+LL+S+ + +K+ DFG + ++ GE GTP YL+PEV
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185
Query: 396 LVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEV 455
L Y + VD W+ GVIL+I L GYPPF + Q L QI +G Y+F W V
Sbjct: 186 L---RKDPYGKPVDIWACGVILYILLVGYPPFWD-EDQHKLYQQIKAGAYDFPSPEWDTV 241
Query: 456 SEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
+ +A +L+ ++L ++P R T ++AL+HPW+
Sbjct: 242 TPEAKNLINQMLTINPAKRITADQALKHPWV 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,939,298
Number of Sequences: 37866
Number of extensions: 957829
Number of successful extensions: 8524
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 656
Number of HSP's successfully gapped in prelim test: 334
Number of HSP's that attempted gapping in prelim test: 4710
Number of HSP's gapped (non-prelim): 1863
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.