Search of human proteins with 6005701

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo
sapiens]
         (1581 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap...  3150   0.0  
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s...  2253   0.0  
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo...  1794   0.0  
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s...  1771   0.0  
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ...  1170   0.0  
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ...  1170   0.0  
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13...   415   e-115
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s...   298   4e-80
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa...   260   6e-69
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform...   252   2e-66
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform...   252   2e-66
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor...   236   1e-61
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor...   236   1e-61
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s...   224   4e-58
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ...   224   4e-58
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]            124   9e-28
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]            124   9e-28
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]            124   9e-28
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap...    80   2e-14
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s...    71   7e-12
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa...    71   7e-12
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ...    70   2e-11
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho...    68   6e-11
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap...    65   5e-10
gi|90421313 cystic fibrosis transmembrane conductance regulator ...    65   7e-10
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7...    64   9e-10
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6...    64   9e-10
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5...    64   9e-10
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3...    64   9e-10
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4...    64   9e-10

>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
          Length = 1581

 Score = 3150 bits (8166), Expect = 0.0
 Identities = 1581/1581 (100%), Positives = 1581/1581 (100%)

Query: 1    MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLL 60
            MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLL
Sbjct: 1    MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLL 60

Query: 61   TMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANY 120
            TMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANY
Sbjct: 61   TMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANY 120

Query: 121  PEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVAL 180
            PEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVAL
Sbjct: 121  PEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVAL 180

Query: 181  QAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYA 240
            QAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYA
Sbjct: 181  QAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYA 240

Query: 241  SVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFM 300
            SVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFM
Sbjct: 241  SVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFM 300

Query: 301  VVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWI 360
            VVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWI
Sbjct: 301  VVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWI 360

Query: 361  LSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420
            LSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE
Sbjct: 361  LSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420

Query: 421  KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI 480
            KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI
Sbjct: 421  KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI 480

Query: 481  RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV 540
            RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV
Sbjct: 481  RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV 540

Query: 541  TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIFLL 600
            TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIFLL
Sbjct: 541  TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIFLL 600

Query: 601  DEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSL 660
            DEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSL
Sbjct: 601  DEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSL 660

Query: 661  FLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPE 720
            FLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPE
Sbjct: 661  FLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPE 720

Query: 721  LYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVE 780
            LYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVE
Sbjct: 721  LYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVE 780

Query: 781  MEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVE 840
            MEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVE
Sbjct: 781  MEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVE 840

Query: 841  YTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALE 900
            YTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALE
Sbjct: 841  YTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALE 900

Query: 901  VDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPS 960
            VDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPS
Sbjct: 901  VDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPS 960

Query: 961  VHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGL 1020
            VHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGL
Sbjct: 961  VHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGL 1020

Query: 1021 SPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMT 1080
            SPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMT
Sbjct: 1021 SPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMT 1080

Query: 1081 YVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFL 1140
            YVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFL
Sbjct: 1081 YVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFL 1140

Query: 1141 SSHLLFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPR 1200
            SSHLLFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPR
Sbjct: 1141 SSHLLFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPR 1200

Query: 1201 SSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKR 1260
            SSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKR
Sbjct: 1201 SSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKR 1260

Query: 1261 KNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF 1320
            KNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF
Sbjct: 1261 KNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF 1320

Query: 1321 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSE 1380
            LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSE
Sbjct: 1321 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSE 1380

Query: 1381 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAE 1440
            GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAE
Sbjct: 1381 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAE 1440

Query: 1441 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAA 1500
            AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAA
Sbjct: 1441 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAA 1500

Query: 1501 RQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQEL 1560
            RQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQEL
Sbjct: 1501 RQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQEL 1560

Query: 1561 GDFEEDFDPSVKWKLLPQEEP 1581
            GDFEEDFDPSVKWKLLPQEEP
Sbjct: 1561 GDFEEDFDPSVKWKLLPQEEP 1581


>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
            sapiens]
          Length = 1624

 Score = 2253 bits (5837), Expect = 0.0
 Identities = 1134/1627 (69%), Positives = 1324/1627 (81%), Gaps = 49/1627 (3%)

Query: 1    MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIY-PHSHQVNDFSSL 59
            M KR++SV QQTWALLCKN LKKWRMKR++L+EWL S LL+L LY++  + HQV+D   +
Sbjct: 1    MSKRRMSVGQQTWALLCKNCLKKWRMKRQTLLEWLFSFLLVLFLYLFFSNLHQVHDTPQM 60

Query: 60   LTMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTAN 119
             +MDLGRVD+FN++ + + + P + TTQ+IMNKVAS PFL G+ ++G PDE+S+ E   N
Sbjct: 61   SSMDLGRVDSFNDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLN 120

Query: 120  YPEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVA 179
            Y  + VRV FT+T+SYHLKF  GH +P  KEH+DH+AHC   NE + CE S FW++GFVA
Sbjct: 121  YSIDAVRVIFTDTFSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVA 180

Query: 180  LQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYY 239
             QAAINAAIIEI TNHSVME+LMSVTG +MK+  F+ Q GV TD ++F CIISFS+FIYY
Sbjct: 181  FQAAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYY 240

Query: 240  ASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGF 299
             SVNVT+ER+ + +LMTMMGLR+SAFWLSWGL+YAGFI IMA  +AL+++S Q ++L+GF
Sbjct: 241  VSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGF 300

Query: 300  MVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEW 359
            ++VF+LFLLYGLSL+ LAFLMS+L+KK FLTGLVVFLL VFWG LGF +LY  LPA LEW
Sbjct: 301  VMVFTLFLLYGLSLITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFLEW 360

Query: 360  ILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYF 419
             L LLSPFAF +GMAQL+HLDYD+NSNA    S    LI+AT FML FDT LYL L +YF
Sbjct: 361  TLCLLSPFAFTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYF 420

Query: 420  EKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEA 479
            +KILP EYGHR  PLFFLKS FW Q  + +HV LE+E D+DP+ +D FE   PEF GKEA
Sbjct: 421  DKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGKEA 480

Query: 480  IRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGS 539
            IRI+N+ KEY GK +++EALK +VFDIYEGQITA+LGHSGAGK+TLLNILSGLSVPT GS
Sbjct: 481  IRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGS 540

Query: 540  VTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEI-- 597
            VT+YN+ LS MAD+EN+SK TG CPQSNVQF FLTV+ENLRLFAKIKGILP EV+KE+  
Sbjct: 541  VTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQR 600

Query: 598  --------------------------------------FLLDEPTAGLDPFSRHQVWNLL 619
                                                   LLDEPTAGLDP SRH++WNLL
Sbjct: 601  VVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLL 660

Query: 620  KERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEI 679
            KE K+DRVILFSTQF+DEADILADRKVF+S GKLKCAGSSLFLKKKWGIGYHLSL LNE 
Sbjct: 661  KEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNER 720

Query: 680  CVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVS 739
            C  E+ITSLVKQHI DAKL+A+SE KL+Y LPLERTNKFPELY+DLD   + GIE+YGVS
Sbjct: 721  CDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQGIEDYGVS 780

Query: 740  MTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVA 799
            +TTLNEVFLKLEGKSTI+ESDI I G++Q + A D   LVE+EQVLSS ++ RKTI GVA
Sbjct: 781  ITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSSFHETRKTISGVA 840

Query: 800  LWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHL 859
            LWRQQ+CAIA+VR LKLK ERK+L  +LL+    F P L+E+   + YQ SY WELSP+ 
Sbjct: 841  LWRQQVCAIAKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKSYPWELSPNT 900

Query: 860  YFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAI 919
            YFL+PGQQP DPLT LL+INKTG++ID+F+ S+  QNIA+EVDAFGTRNGTDDPSYNGAI
Sbjct: 901  YFLSPGQQPQDPLTHLLVINKTGSTIDNFLHSLRRQNIAIEVDAFGTRNGTDDPSYNGAI 960

Query: 920  TVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPI 979
             V  +EK++ FS+ACN KRLNCFPVL+D++SNGLLG+   S HI+T+RSTF E   D   
Sbjct: 961  IVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEY 1020

Query: 980  GFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL 1039
            G+ +   FW+ + +S  PYIAMSSI DYK +A SQLRISGL PSAYWFGQALVDVSLYFL
Sbjct: 1021 GYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL 1080

Query: 1040 VFVFIYLMSYISNFEDMLLTIIHI-IQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWS 1098
            + + + +M YI + E+++  I ++ IQI C++GY  SL+F+TYVISFIFR GRKNSGIWS
Sbjct: 1081 ILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWS 1140

Query: 1099 FCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSL----FSEER 1154
            F F +V +FS+     + +     F  T LIPP T+IG LF+ S +   S+     SE  
Sbjct: 1141 FFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESE 1200

Query: 1155 MDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGE 1214
            +    +L  LIP+LHF+IFLF LRCLE    KK MRKDP FRISPRS+ +  NPEEPEGE
Sbjct: 1201 I---VYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGE 1257

Query: 1215 DEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVR 1274
            +ED+QMER+RT NA+   +FDE PVIIASCLRKEYAGK+K CFSKRK KIATRNVSFCV+
Sbjct: 1258 EEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVK 1317

Query: 1275 KGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWPNL 1334
            KGEV+GLLGHNGAGKST+IK+ITGDTKPTAGQV+LKGSGGG+ L FLGYCPQENALWPNL
Sbjct: 1318 KGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGFLGYCPQENALWPNL 1377

Query: 1335 TVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILG 1394
            TVRQHLEVYAAVKGLRKGDA +AITRLVDALKLQDQLK+PVKTLSEGIKRKLCFVLSILG
Sbjct: 1378 TVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILG 1437

Query: 1395 NPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG 1454
            NPSVVLLDEPSTGMDPEGQQQMWQ IRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG
Sbjct: 1438 NPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSG 1497

Query: 1455 RLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLP 1514
            RLRCIGSIQHLKSKFGKDYLLEMK+KNLAQ+EPLHAEILRLFPQAA+QER+SSLMVYKLP
Sbjct: 1498 RLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLP 1557

Query: 1515 VEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWK 1574
            VEDV+PL+QAFFKLE VKQSFDLEEYSLSQSTLEQVFLELSKEQELGD EEDFDPSVKWK
Sbjct: 1558 VEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWK 1617

Query: 1575 LLPQEEP 1581
            LL QEEP
Sbjct: 1618 LLLQEEP 1624


>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
            sapiens]
          Length = 1543

 Score = 1794 bits (4646), Expect = 0.0
 Identities = 918/1543 (59%), Positives = 1139/1543 (73%), Gaps = 51/1543 (3%)

Query: 90   MNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFLLGHGMPAKK 149
            MNK+A   F+ G+ V+G PDEE++         E+V V F++T+SY LKF  G+ +P  K
Sbjct: 1    MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK 60

Query: 150  EHKDHTAHCYETNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNM 209
            EH ++T HC+  + +++C ++ +W +GFVA QAAINAAIIE+TTNHSVMEEL SV G NM
Sbjct: 61   EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM 120

Query: 210  KMHSFIGQSGVITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSW 269
            K+  FI +  ++ + + F+C++SFSSFIY+AS+NV RER + K LMT+MGLR+SAFWLSW
Sbjct: 121  KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW 180

Query: 270  GLLYAGFIFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFL 329
            GL Y  FIFIM++F+ALVI S   +  +GFMV+F+L+ LYGLSL+ALAFLMS+L++K  L
Sbjct: 181  GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML 240

Query: 330  TGLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFP 389
             GL  FL TVFWGCLGFT LYR LP SL W+LSLLSPFAF  GMAQ+ HLD  L+   FP
Sbjct: 241  AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP 300

Query: 390  HPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTD 449
             PS  S  ++AT F+LAFDT  YL   +YFE++LP++ GH   PLFFLKSSFWS+ Q T 
Sbjct: 301  DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH 360

Query: 450  HVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEG 509
            H   E+E++ + S  DSFE   PEF GKEAIRIRNV KEY GK  K+EAL+ + FDIYEG
Sbjct: 361  HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420

Query: 510  QITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQ 569
            QITAILGH+GAGKSTLLNILSGLSV T+GS TIYN +LSE+ D+E + K  G CPQ N Q
Sbjct: 421  QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480

Query: 570  FDFLTVRENLRLFAKIKGILPQEVDKEI-------------------------------- 597
            FDFLTVRENLR+FAKIKGI P+EV++E+                                
Sbjct: 481  FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540

Query: 598  --------FLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLS 649
                     LLDEPTAGLDPFSRH+VW+LLKE K DR+ILFSTQFMDEADILADRKVFLS
Sbjct: 541  AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS 600

Query: 650  QGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYT 709
             GKLKCAGSSLFLK+KWGIGYHLSL  NE+C  E ITSL+KQHIPDAKL+ +SE KL+Y+
Sbjct: 601  NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS 660

Query: 710  LPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQA 769
            LPLE+TNKFP+LY DLD   D GI NY VS+T+LNEVFL LEGKS I+E D  I  + + 
Sbjct: 661  LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI 720

Query: 770  EKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLI 829
                +T    EMEQVL SL + RK +   ALWR+QI A+A +R LKL+ ER+ALL LLL+
Sbjct: 721  HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV 780

Query: 830  LMAGFCPLLVEYTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFI 889
            L   F P+++E  M K+ + ++ WE SP +YFL+  Q P  PLT LLI+N TG++I+D +
Sbjct: 781  LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV 840

Query: 890  QSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIV 949
             S++ Q+I LE+D F  RNG+DDPSYNGAI V  ++K+Y FS+ACN K+LNCFPVLM IV
Sbjct: 841  HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV 900

Query: 950  SNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKN 1009
            SN L+G+   +  I+ E ++F  +     +GF+   +F L++T+   P+I MSSI DYK 
Sbjct: 901  SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK 960

Query: 1010 RARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCA 1069
              +SQL ISGL PSAYW GQALVD+ LYFL+   I+L+ Y       L   +  + + C 
Sbjct: 961  NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCI 1020

Query: 1070 VGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLI 1129
            +G + SLIF+TYV+SFIFRK RKN+G WSF F+++ +        + +E     +    I
Sbjct: 1021 IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFI 1080

Query: 1130 PPATMIGCLFLSSHLLFSSLFSE-----ERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKF 1184
            P  T++G + L   L F             ++    L  LIP+L  +IFLF +RCLE K+
Sbjct: 1081 PSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKY 1140

Query: 1185 GKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASC 1244
            G + M KDP FRISPRS +   NPEEPE EDEDVQ ERV+ ANAL + N +E+PVI ASC
Sbjct: 1141 GNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASC 1200

Query: 1245 LRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTA 1304
            L KEY   +K CFS RK KIA RNVSFCV+KGEVLGLLGHNGAGKSTSIK+ITG TKPTA
Sbjct: 1201 LHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA 1260

Query: 1305 GQVLLKGSGGG------DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAI 1358
            G V+L+GS         ++L+FLGYCPQEN+LWP LT+++HLE+YAAVKGL K DA ++I
Sbjct: 1261 GVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSI 1320

Query: 1359 TRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQ 1418
            +RLV+ALKLQ+QLK+PVKTLSEGIKRKLCFVLSILGNPSVVLLDEP TGMDPEGQQQMWQ
Sbjct: 1321 SRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ 1380

Query: 1419 AIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMK 1478
             ++AT +N ERG LLTTHYM+EAEAVCDR+A+MVSG LRCIGSIQHLK+KFG+DYLLE+K
Sbjct: 1381 ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIK 1440

Query: 1479 VKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLE 1538
            +K   QVE LH EIL+LFPQAA QERYSSLM YKLPVEDV PL++AFFKLE +KQ+F+LE
Sbjct: 1441 MKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLE 1500

Query: 1539 EYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEEP 1581
            EYSLSQ+TLEQVFLEL KEQELG+ ++  D +V+WKLLPQE+P
Sbjct: 1501 EYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP 1543


>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
            sapiens]
          Length = 1617

 Score = 1771 bits (4586), Expect = 0.0
 Identities = 932/1628 (57%), Positives = 1149/1628 (70%), Gaps = 61/1628 (3%)

Query: 1    MRKRKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLL 60
            M  ++ SV QQT ALLCKNFLKKWRMKRESL+EW  S+LL LC+ ++  S +   F  + 
Sbjct: 1    MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMA 60

Query: 61   TMDLGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANY 120
              +LGRVD FN S   VVYTP++N TQQIMNK A  P L G  V+G P++  + E     
Sbjct: 61   PQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLEN 120

Query: 121  PEEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVAL 180
                + + F  T+SY L F  G+  P  KE  D +AHC++   +  C ++ +W  GFVAL
Sbjct: 121  LPYAMGIIFNETFSYKLIFFQGYNSPLWKE--DFSAHCWDGYGEFSCTLTKYWNRGFVAL 178

Query: 181  QAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYA 240
            Q AIN AIIEITTNH VMEELMSVT   MK   FI ++ +  ++++   ++ FS  +Y+ 
Sbjct: 179  QTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFI 238

Query: 241  SVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFM 300
            S+NVT+ERK+ K LM MMGL+DSAFWLSWGL+YAGFIFI+++F+ ++I  TQ I+++GFM
Sbjct: 239  SLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFM 298

Query: 301  VVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTSLYRHLPASLEWI 360
            V+F LF LYGLSLVAL FLMS+L+KK+ LT LVVFLLT+FWGCLGFT  Y  LP+SLEWI
Sbjct: 299  VIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWI 358

Query: 361  LSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420
            L++ SPFAF  GM Q++ LDY+LN   FP PS  S  ++AT  ML  D  +YL LA+YF+
Sbjct: 359  LNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFD 418

Query: 421  KILPNEYGHRR--PPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKE 478
            KILP  YG  R   PLFFL SS   Q Q+T+   +E E+DA+    D FE   PEFQGKE
Sbjct: 419  KILP--YGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKE 476

Query: 479  AIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKG 538
            AIRIRNV KEYKGK  K+EALK L+FDIYEGQITAILGHSGAGKS+LLNIL+GLSVPT+G
Sbjct: 477  AIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEG 536

Query: 539  SVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE-- 596
            SVTIYN  LSEM DLE + K+TGVCPQ NVQFD LTV+ENL LFAKIKGI  +EV++E  
Sbjct: 537  SVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQ 596

Query: 597  --------------------------------------IFLLDEPTAGLDPFSRHQVWNL 618
                                                  I LLDEPT GLDPFSR QVW+L
Sbjct: 597  RILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSL 656

Query: 619  LKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNE 678
            L+ER+ D VILFSTQ MDEADILADRKV +S G+LKCAGSS+FLK++WG+GYHLSL  NE
Sbjct: 657  LRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNE 716

Query: 679  ICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGV 738
            IC  E ITS +  HIPDAKL  +++ KL+YTLPLERTN FP+L+ DLD   D G+  Y +
Sbjct: 717  ICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDI 776

Query: 739  SMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGV 798
            SM+TLNEVF+KLEG+STI E D       Q E   D+E L EME   SS ++M+  +  +
Sbjct: 777  SMSTLNEVFMKLEGQSTI-EQDFE-----QVEMIRDSESLNEMELAHSSFSEMQTAVSDM 830

Query: 799  ALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPH 858
             LWR Q+ A+AR+R LKLK + K LL LLL+      PL+VE  M  +      WE    
Sbjct: 831  GLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNE 890

Query: 859  LYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGA 918
            LYFL+PGQ P +P T LLIIN T ++I+DFI+S++HQNI LEVD F  RNGTD  SYNGA
Sbjct: 891  LYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGA 950

Query: 919  ITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNP 978
            I V   +K+Y FS+ CN KRL+CFP+LM+I+SNGLL M   + HIR E S F  +     
Sbjct: 951  IIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLW 1010

Query: 979  IGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYF 1038
             G      F  ++  S  PYI M SI DYK  A+SQL ISGL  SAYW GQALVDVS + 
Sbjct: 1011 TGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFI 1070

Query: 1039 LVFVFIYLMSYISNFEDMLLTIIHIIQIPCAV-GYSFSLIFMTYVISFIFRKGRKNSGIW 1097
            L+ + +YL+ YI N + +L+T   +  +     GY+ SL+F  Y+ISFIFRK RKNSG+W
Sbjct: 1071 LILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLW 1130

Query: 1098 SFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGC---LFLSSHLLFSSLFSEER 1154
            SF F+  +    +    + F+  I      L+P  T++G    L +     +   F E  
Sbjct: 1131 SFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYRE-FPEAN 1189

Query: 1155 MDVQP--FLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPE 1212
             ++    FLV  IP+   ++F+F LRC+E K GKK MRKDP FRISP+S D   NPEEP 
Sbjct: 1190 FELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPI 1249

Query: 1213 GEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFC 1272
             EDED+Q ER+RTA AL ++  DEKPVIIASCL KEYAG++K CFSKRK KIA RN+SFC
Sbjct: 1250 DEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFC 1309

Query: 1273 VRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWP 1332
            V++GE+LGLLG NGAGKS+SI++I+G TKPTAG+V LKG      L  LGYCPQEN LWP
Sbjct: 1310 VQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSS--VLGHLGYCPQENVLWP 1367

Query: 1333 NLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSI 1392
             LT+R+HLEVYAAVKGLRK DA +AI RLV A KL +QL  PV+ L+ GI RKLCFVLS+
Sbjct: 1368 MLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSL 1427

Query: 1393 LGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMV 1452
            LGN  V+LLDEPSTG+DP GQQQMWQAI+A  +NTERG LLTTH +AEAEA+CDRVAIMV
Sbjct: 1428 LGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMV 1487

Query: 1453 SGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFPQAARQERYSSLMVYK 1512
            SGRLRCIGSIQHLK+K GKDY+LE+KVK  +QV  +H EIL+LFPQAA QERYSSL+ YK
Sbjct: 1488 SGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYK 1547

Query: 1513 LPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVK 1572
            LPV DV PL+Q F KLE VK +F+LEEYSLSQ TLE+VFLELSKEQE+G+F+E+ D +++
Sbjct: 1548 LPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMR 1607

Query: 1573 WKLLPQEE 1580
            WKLLP  +
Sbjct: 1608 WKLLPHSD 1615


>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
            sapiens]
          Length = 1642

 Score = 1170 bits (3026), Expect = 0.0
 Identities = 658/1628 (40%), Positives = 978/1628 (60%), Gaps = 82/1628 (5%)

Query: 4    RKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMD 63
            R++ V +QT  LL KN+L K R K+ S+ E L  L  L  L +    H    +  +  ++
Sbjct: 6    REVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIE 65

Query: 64   LGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEE 123
            L  +D F  S   + YTPVTN T  IM KV++             +E+ +   + + P  
Sbjct: 66   LNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSN 125

Query: 124  IVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVALQAA 183
             V V F ++ SY L+F     +P    + D  A C ++     CE + +W  GF  LQA+
Sbjct: 126  FVGVVFKDSMSYELRFFPDM-IPVSSIYMDSRAGCSKS-----CEAAQYWSSGFTVLQAS 179

Query: 184  INAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYASVN 243
            I+AAII++ TN S+ +EL S     M   + +        + L   +I+FS F Y+ +++
Sbjct: 180  IDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIH 239

Query: 244  VTRER-KRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFMVV 302
            +  E+ K++K  + +MGL D+AFWLSW LLY   IF+M+L +A++  ++     S  +V+
Sbjct: 240  IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVI 299

Query: 303  FSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTS-LYRHLPASLEWIL 361
            F LF LYGLS V  A +++ L KKS   G+V F +TV +G +G    L    P SL W+ 
Sbjct: 300  FLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLF 359

Query: 362  SLLSPFAFMLGMAQLLHLDYDLNSNA-FPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420
            S      F++G+AQ++HL+ D N  A F + + G   ++ T  ML  ++  Y+ LA+Y +
Sbjct: 360  SPFCHCTFVIGIAQVMHLE-DFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLD 418

Query: 421  KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI 480
            +++P E+G RR  L+FLK S+WS++++      E  ++ + SF +  E    EF GKEAI
Sbjct: 419  QVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAI 478

Query: 481  RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV 540
            RI  + K Y+ K + +EAL++L FDIYEGQITA+LGHSG GKSTL+NIL GL  P+ G  
Sbjct: 479  RISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFA 538

Query: 541  TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGI----LPQEVDK- 595
            +IY +++SE+ ++    K+ G+CPQ ++ FD LTV ENL + A IKGI    + QEV K 
Sbjct: 539  SIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKV 598

Query: 596  -----------------------------------EIFLLDEPTAGLDPFSRHQVWNLLK 620
                                               +I LLDEPTAG+DP SRH VWNLLK
Sbjct: 599  LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658

Query: 621  ERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEIC 680
             RK +RV +FST FMDEADILADRK  +SQG LKC GSS+FLK KWGIGY LS+ +++ C
Sbjct: 659  YRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYC 718

Query: 681  VEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSM 740
              E+++SLVKQHIP A L  +++ +L+Y+LP +  +KF  L+  LDS+ +LG+ +YGVSM
Sbjct: 719  ATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSM 778

Query: 741  TTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKT-IGGVA 799
            TTL +VFLKLE ++ I+++D ++  +   E+  D++   EMEQ L  L++ +   +  ++
Sbjct: 779  TTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMS 838

Query: 800  LWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYT-WELSPH 858
            LW+QQ+  IA+     LK E K++ ++LL+L+  F   +  + +   ++N+    +L P 
Sbjct: 839  LWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPD 898

Query: 859  LYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGA 918
            LYFL PG +PH   T LL+ N   + I D I     QNI   V      +      ++ A
Sbjct: 899  LYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIM--VTMINDSDYVSVAPHSAA 956

Query: 919  ITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNP 978
            + V  +EK+Y F+   N+  +   P+L++I+SN  L  +  +  I+   + F +   D  
Sbjct: 957  LNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIV 1016

Query: 979  IGFLAYIMFWL--VLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSL 1036
                 Y    L  ++ ++ PPY AM + +++K +A +QL++SGL PSAYW GQA+VD+ L
Sbjct: 1017 FKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPL 1076

Query: 1037 YFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGI 1096
            +F++ + +       ++     T+  +  + C +GY  S+I  TY+ SF F+K       
Sbjct: 1077 FFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEF 1136

Query: 1097 WSFCFYVVTVFSVAGFAFSIF-----ESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFS 1151
            WSF + V  +  +A    + F      + + + F  +IP   ++GCL     + + ++  
Sbjct: 1137 WSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNV-- 1194

Query: 1152 EERMDVQPF-------LVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDV 1204
              R +V  +       +  + P+L  ++++F L+  E K+G +S+RKDPFFR     S  
Sbjct: 1195 --RKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKN 1252

Query: 1205 CQNPEEP--EGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKN 1262
             + PE P  E EDEDV+ ER++    +     +EKP I+ S L KEY  K+    S++  
Sbjct: 1253 RKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVK 1312

Query: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLL-----KGSGGGDA 1317
            K+AT+ +SFCV+KGE+LGLLG NGAGKST I ++ GD +PT+GQV L     + S   D+
Sbjct: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372

Query: 1318 LEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKT 1377
            L+ +GYCPQ N LWP+ T+++H E+Y AVKG+   D +  I+R+  AL L++ L+  VK 
Sbjct: 1373 LKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKK 1432

Query: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
            L  GIKRKLCF LS+LGNP + LLDEPSTGMDP+ +Q MW+AIR  F+N +R A+LTTHY
Sbjct: 1433 LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHY 1492

Query: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNL---AQVEPLHAEILR 1494
            M EAEAVCDRVAIMVSG+LRCIG++QHLKSKFGK Y LE+K+K+     +V+ L  EI  
Sbjct: 1493 MEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQY 1552

Query: 1495 LFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLEL 1554
            +FP A+RQE +SS++ YK+P EDVQ L+Q+FFKLE+ K +F +EEYS SQ+TLEQVF+EL
Sbjct: 1553 IFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVEL 1612

Query: 1555 SKEQELGD 1562
            +KEQE  D
Sbjct: 1613 TKEQEEED 1620



 Score =  143 bits (360), Expect = 1e-33
 Identities = 145/620 (23%), Positives = 260/620 (41%), Gaps = 94/620 (15%)

Query: 238  YYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA---LVIRSTQFI 294
            Y+A  N    + +    + + GL  SA+W+   ++     FI+ + +    L      + 
Sbjct: 1038 YFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYF 1097

Query: 295  ILSGFMVVFSLFLLYGLSLVALAFLMSILVKK--------SFL---TGLVVFLLTVFWGC 343
                F+ V    + Y  S++   ++ S   KK        SF+     L    +T     
Sbjct: 1098 YTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFF 1157

Query: 344  LGFTSLYRHLPASLEWILSLLSPFAFMLG-MAQLLHLDY-DLNSNAFPH-PSDGSNLIVA 400
            +G+T     +   L +   ++ P   +LG +   + + + ++  N   + P D  ++ V 
Sbjct: 1158 MGYT-----IATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVI 1212

Query: 401  TNFMLAFDTCLYLALAIYFEKILPNEYGHR--RPPLFFLKSSFWSQTQKTDHVALEDEMD 458
            + ++      L++ L  Y+EK    +YG R  R   FF   S  S+ +K       ++ D
Sbjct: 1213 SPYL---QCVLWIFLLQYYEK----KYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDED 1265

Query: 459  ADPSFHDSFEQAPPEFQG------KEAIRIRNVTKEYKGKPD-------KIEALKDLVFD 505
             D            E  G      K +I + N+ KEY  K D       K  A K + F 
Sbjct: 1266 EDVKAE---RLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFC 1322

Query: 506  IYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQ 565
            + +G+I  +LG +GAGKST++NIL G   PT G V +  +  SE ++ ++  K  G CPQ
Sbjct: 1323 VKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFL-GDYSSETSEDDDSLKCMGYCPQ 1381

Query: 566  SNVQFDFLTVRENLRLFAKIKGI----------------------------LPQEVDK-- 595
             N  +   T++E+  ++  +KG+                            LP  + +  
Sbjct: 1382 INPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKL 1441

Query: 596  ----------EIFLLDEPTAGLDPFSRHQVWNLLKE--RKTDRVILFSTQFMDEADILAD 643
                      +I LLDEP+ G+DP ++  +W  ++   +   R  + +T +M+EA+ + D
Sbjct: 1442 CFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCD 1501

Query: 644  RKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVK--QHI-PDAKLSA 700
            R   +  G+L+C G+   LK K+G GY L ++L +      +  L +  Q+I P+A    
Sbjct: 1502 RVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQE 1561

Query: 701  KSEGKLIYTLPLERTNKFPELYKDLDSYPD-LGIENYGVSMTTLNEVFLKLEGKSTINES 759
                 L Y +P E      + +  L+       IE Y  S  TL +VF++L  +    ++
Sbjct: 1562 SFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDN 1621

Query: 760  DIAILGEVQAEKADDTERLV 779
                L      +    +R+V
Sbjct: 1622 SCGTLNSTLWWERTQEDRVV 1641


>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
            sapiens]
          Length = 1642

 Score = 1170 bits (3026), Expect = 0.0
 Identities = 658/1628 (40%), Positives = 978/1628 (60%), Gaps = 82/1628 (5%)

Query: 4    RKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMD 63
            R++ V +QT  LL KN+L K R K+ S+ E L  L  L  L +    H    +  +  ++
Sbjct: 6    REVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIE 65

Query: 64   LGRVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEE 123
            L  +D F  S   + YTPVTN T  IM KV++             +E+ +   + + P  
Sbjct: 66   LNPMDKFTLSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSN 125

Query: 124  IVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEVSVFWKEGFVALQAA 183
             V V F ++ SY L+F     +P    + D  A C ++     CE + +W  GF  LQA+
Sbjct: 126  FVGVVFKDSMSYELRFFPDM-IPVSSIYMDSRAGCSKS-----CEAAQYWSSGFTVLQAS 179

Query: 184  INAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFIYYASVN 243
            I+AAII++ TN S+ +EL S     M   + +        + L   +I+FS F Y+ +++
Sbjct: 180  IDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIH 239

Query: 244  VTRER-KRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFMVV 302
            +  E+ K++K  + +MGL D+AFWLSW LLY   IF+M+L +A++  ++     S  +V+
Sbjct: 240  IVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVI 299

Query: 303  FSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTS-LYRHLPASLEWIL 361
            F LF LYGLS V  A +++ L KKS   G+V F +TV +G +G    L    P SL W+ 
Sbjct: 300  FLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLF 359

Query: 362  SLLSPFAFMLGMAQLLHLDYDLNSNA-FPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE 420
            S      F++G+AQ++HL+ D N  A F + + G   ++ T  ML  ++  Y+ LA+Y +
Sbjct: 360  SPFCHCTFVIGIAQVMHLE-DFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLD 418

Query: 421  KILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAI 480
            +++P E+G RR  L+FLK S+WS++++      E  ++ + SF +  E    EF GKEAI
Sbjct: 419  QVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAI 478

Query: 481  RIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV 540
            RI  + K Y+ K + +EAL++L FDIYEGQITA+LGHSG GKSTL+NIL GL  P+ G  
Sbjct: 479  RISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFA 538

Query: 541  TIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGI----LPQEVDK- 595
            +IY +++SE+ ++    K+ G+CPQ ++ FD LTV ENL + A IKGI    + QEV K 
Sbjct: 539  SIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKV 598

Query: 596  -----------------------------------EIFLLDEPTAGLDPFSRHQVWNLLK 620
                                               +I LLDEPTAG+DP SRH VWNLLK
Sbjct: 599  LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLK 658

Query: 621  ERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEIC 680
             RK +RV +FST FMDEADILADRK  +SQG LKC GSS+FLK KWGIGY LS+ +++ C
Sbjct: 659  YRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYC 718

Query: 681  VEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPDLGIENYGVSM 740
              E+++SLVKQHIP A L  +++ +L+Y+LP +  +KF  L+  LDS+ +LG+ +YGVSM
Sbjct: 719  ATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSM 778

Query: 741  TTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKT-IGGVA 799
            TTL +VFLKLE ++ I+++D ++  +   E+  D++   EMEQ L  L++ +   +  ++
Sbjct: 779  TTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAALVSTMS 838

Query: 800  LWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYT-WELSPH 858
            LW+QQ+  IA+     LK E K++ ++LL+L+  F   +  + +   ++N+    +L P 
Sbjct: 839  LWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVPD 898

Query: 859  LYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGA 918
            LYFL PG +PH   T LL+ N   + I D I     QNI   V      +      ++ A
Sbjct: 899  LYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIM--VTMINDSDYVSVAPHSAA 956

Query: 919  ITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNP 978
            + V  +EK+Y F+   N+  +   P+L++I+SN  L  +  +  I+   + F +   D  
Sbjct: 957  LNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIV 1016

Query: 979  IGFLAYIMFWL--VLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSL 1036
                 Y    L  ++ ++ PPY AM + +++K +A +QL++SGL PSAYW GQA+VD+ L
Sbjct: 1017 FKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPL 1076

Query: 1037 YFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGI 1096
            +F++ + +       ++     T+  +  + C +GY  S+I  TY+ SF F+K       
Sbjct: 1077 FFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEF 1136

Query: 1097 WSFCFYVVTVFSVAGFAFSIF-----ESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFS 1151
            WSF + V  +  +A    + F      + + + F  +IP   ++GCL     + + ++  
Sbjct: 1137 WSFIYSVAALACIAITEITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNV-- 1194

Query: 1152 EERMDVQPF-------LVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDV 1204
              R +V  +       +  + P+L  ++++F L+  E K+G +S+RKDPFFR     S  
Sbjct: 1195 --RKNVDTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKN 1252

Query: 1205 CQNPEEP--EGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKN 1262
             + PE P  E EDEDV+ ER++    +     +EKP I+ S L KEY  K+    S++  
Sbjct: 1253 RKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVK 1312

Query: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLL-----KGSGGGDA 1317
            K+AT+ +SFCV+KGE+LGLLG NGAGKST I ++ GD +PT+GQV L     + S   D+
Sbjct: 1313 KVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDS 1372

Query: 1318 LEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKT 1377
            L+ +GYCPQ N LWP+ T+++H E+Y AVKG+   D +  I+R+  AL L++ L+  VK 
Sbjct: 1373 LKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKK 1432

Query: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
            L  GIKRKLCF LS+LGNP + LLDEPSTGMDP+ +Q MW+AIR  F+N +R A+LTTHY
Sbjct: 1433 LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHY 1492

Query: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNL---AQVEPLHAEILR 1494
            M EAEAVCDRVAIMVSG+LRCIG++QHLKSKFGK Y LE+K+K+     +V+ L  EI  
Sbjct: 1493 MEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQY 1552

Query: 1495 LFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLEL 1554
            +FP A+RQE +SS++ YK+P EDVQ L+Q+FFKLE+ K +F +EEYS SQ+TLEQVF+EL
Sbjct: 1553 IFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVEL 1612

Query: 1555 SKEQELGD 1562
            +KEQE  D
Sbjct: 1613 TKEQEEED 1620



 Score =  143 bits (360), Expect = 1e-33
 Identities = 145/620 (23%), Positives = 260/620 (41%), Gaps = 94/620 (15%)

Query: 238  YYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA---LVIRSTQFI 294
            Y+A  N    + +    + + GL  SA+W+   ++     FI+ + +    L      + 
Sbjct: 1038 YFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYF 1097

Query: 295  ILSGFMVVFSLFLLYGLSLVALAFLMSILVKK--------SFL---TGLVVFLLTVFWGC 343
                F+ V    + Y  S++   ++ S   KK        SF+     L    +T     
Sbjct: 1098 YTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFF 1157

Query: 344  LGFTSLYRHLPASLEWILSLLSPFAFMLG-MAQLLHLDY-DLNSNAFPH-PSDGSNLIVA 400
            +G+T     +   L +   ++ P   +LG +   + + + ++  N   + P D  ++ V 
Sbjct: 1158 MGYT-----IATILHYAFCIIIPIYPLLGCLISFIKISWKNVRKNVDTYNPWDRLSVAVI 1212

Query: 401  TNFMLAFDTCLYLALAIYFEKILPNEYGHR--RPPLFFLKSSFWSQTQKTDHVALEDEMD 458
            + ++      L++ L  Y+EK    +YG R  R   FF   S  S+ +K       ++ D
Sbjct: 1213 SPYL---QCVLWIFLLQYYEK----KYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDED 1265

Query: 459  ADPSFHDSFEQAPPEFQG------KEAIRIRNVTKEYKGKPD-------KIEALKDLVFD 505
             D            E  G      K +I + N+ KEY  K D       K  A K + F 
Sbjct: 1266 EDVKAE---RLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFC 1322

Query: 506  IYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQ 565
            + +G+I  +LG +GAGKST++NIL G   PT G V +  +  SE ++ ++  K  G CPQ
Sbjct: 1323 VKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFL-GDYSSETSEDDDSLKCMGYCPQ 1381

Query: 566  SNVQFDFLTVRENLRLFAKIKGI----------------------------LPQEVDK-- 595
             N  +   T++E+  ++  +KG+                            LP  + +  
Sbjct: 1382 INPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKL 1441

Query: 596  ----------EIFLLDEPTAGLDPFSRHQVWNLLKE--RKTDRVILFSTQFMDEADILAD 643
                      +I LLDEP+ G+DP ++  +W  ++   +   R  + +T +M+EA+ + D
Sbjct: 1442 CFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCD 1501

Query: 644  RKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVK--QHI-PDAKLSA 700
            R   +  G+L+C G+   LK K+G GY L ++L +      +  L +  Q+I P+A    
Sbjct: 1502 RVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQE 1561

Query: 701  KSEGKLIYTLPLERTNKFPELYKDLDSYPD-LGIENYGVSMTTLNEVFLKLEGKSTINES 759
                 L Y +P E      + +  L+       IE Y  S  TL +VF++L  +    ++
Sbjct: 1562 SFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDN 1621

Query: 760  DIAILGEVQAEKADDTERLV 779
                L      +    +R+V
Sbjct: 1622 SCGTLNSTLWWERTQEDRVV 1641


>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
            [Homo sapiens]
          Length = 5058

 Score =  415 bits (1066), Expect = e-115
 Identities = 428/1581 (27%), Positives = 692/1581 (43%), Gaps = 244/1581 (15%)

Query: 177  FVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHS---FIGQSGVITDLYLFSCIISF 233
            F  LQ  I  AII + T    +E            H+   F+   G     + F  I+  
Sbjct: 3524 FAPLQDMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVG-----FFFPLIMML 3578

Query: 234  SSFIYYASVN---VTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRS 290
            +  +  AS+    V  +  +++  M MMG+     +L+W L     + I +  LA+V+++
Sbjct: 3579 TWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKT 3638

Query: 291  TQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTV--FWGCLGFTS 348
            +     S   +VF   L +G+S+V L++L+S    ++    L   L+ +  F   +    
Sbjct: 3639 SGIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLV 3698

Query: 349  LYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLN----SNAFPHPSDGSNLIVATNFM 404
            L+  L    +  L LLS  AF  G+  +  L+        +N +     G        +M
Sbjct: 3699 LHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWM 3758

Query: 405  LAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQT----QKTDHVALEDEMDAD 460
            + FD+ LY     Y   ++P  +G R+P  F   +S+W       +K  +         +
Sbjct: 3759 ILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFN 3818

Query: 461  PSFHD---SFEQAPPEFQGKE-AIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILG 516
             +F +   S +    E +G    + + +VTKEY+G    ++   DL    Y  QITA+LG
Sbjct: 3819 ENFDNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQ---DLSLTFYRDQITALLG 3875

Query: 517  HSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVR 576
             +GAGK+T++++L+GL  PT G++ I    L    DL  +    GVCPQ ++  D LTVR
Sbjct: 3876 TNGAGKTTIISMLTGLHPPTSGTIIINGKNLQ--TDLSRVRMELGVCPQQDILLDNLTVR 3933

Query: 577  ENLRLFAKIKGILPQEVDKEIF-------------------------------------- 598
            E+L LFA IK   PQ   KE+                                       
Sbjct: 3934 EHLLLFASIKA--PQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFM 3991

Query: 599  ------LLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGK 652
                  +LDEPT+G+DP SRH +W++L + +  R I+F+T  +DEA+ L+DR   L  G+
Sbjct: 3992 GMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGR 4051

Query: 653  LKCAGSSLFLKKKWGIGYHLSLQLNEICVEEN-------ITSLVKQHIPDAKLSAKSEGK 705
            L+C G    LK+ +G G  L+L      +E +       +TSL+K +IP A L   S  +
Sbjct: 4052 LRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSE 4111

Query: 706  LIYTLPLERTNK--FPELYKDLD-SYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIA 762
            L YT+P + T+K     L++ LD +   L +  YG+S TTL EVFL L   S   +S IA
Sbjct: 4112 LTYTIPKD-TDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLLQDSN-KKSHIA 4169

Query: 763  ILGEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKA 822
            +  E + +    T  L        SL +   T+ GV L R Q+ AI   RL +     K+
Sbjct: 4170 LGTESELQNHRPTGHL---SGYCGSLARPA-TVQGVQLLRAQVAAILARRLRRTLRAGKS 4225

Query: 823  LLA--LLLILMAGFC-------PLLVEYTMVKI----YQ--------------------- 848
             LA  LL +L            PL  EY  +++    YQ                     
Sbjct: 4226 TLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTPGHYQRAETYFFSSGGDNLDLTRVLL 4285

Query: 849  ------------------NSYTWELSPHLY---------FLAPGQQPHDP-LTQLL---I 877
                              NS  W   P  +            P +    P LT  L   +
Sbjct: 4286 RKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQDSCGCLKCPNRSASAPYLTNHLGHTL 4345

Query: 878  INKTGASIDDFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAIT-------VCCNEKNYSF 930
            +N +G ++++++ +   +   L   +FG +  ++    NG I+       V  N+K +  
Sbjct: 4346 LNLSGFNMEEYLLAPSEKP-RLGGWSFGLKIPSEAGGANGNISKPPTLAKVWYNQKGFH- 4403

Query: 931  SLACNAKRLNCF------PVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAY 984
            SL      LN        P  +D    G+     P       +   LE+ +   +  L  
Sbjct: 4404 SLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKILESIRQCGVA-LCI 4462

Query: 985  IMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL----- 1039
            ++ + +L++S    I  S + D    A+    ISGL    YWF   L D+  Y +     
Sbjct: 4463 VLGFSILSAS----IGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLC 4518

Query: 1040 VFVFIYLMSYISNFED------MLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKN 1093
            V V +        F        +LL++     +P    Y  S IF +  ++FI       
Sbjct: 4519 VAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWM--YLMSRIFSSSDVAFISYVSL-- 4574

Query: 1094 SGIWSFCFYVVTVF-------SVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLF 1146
            + I+  C  ++T+        S A    +I++  + ++FT         G + L  + + 
Sbjct: 4575 NFIFGLCTMLITIMPRLLAIISKAKNLQNIYDV-LKWVFTIFPQFCLGQGLVELCYNQIK 4633

Query: 1147 SSLFSEERMD--VQPFLVFLIPFLHF------IIFLFTLRCLEWKFGKKSMRKDPFFRIS 1198
              L     +D  V PF +  + ++         + L     L W   +            
Sbjct: 4634 YDLTHNFGIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRW----------- 4682

Query: 1199 PRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFS 1258
            PR     Q   +   +D DV+ E  R       TN D   +++   L K Y    +  F 
Sbjct: 4683 PRGHSTLQGTVK-SSKDTDVEKEEKRVFEG--RTNGD---ILVLYNLSKHY----RRFF- 4731

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG------- 1311
              +N IA +++S  + KGE  GLLG NGAGKST+ K++ G+   T+G  +++        
Sbjct: 4732 --QNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVD 4789

Query: 1312 -SGGGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQ 1370
             S  G A   +GYCPQ++AL   LT  +HL  Y +++G+ +         L+  L L+  
Sbjct: 4790 LSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAH 4849

Query: 1371 LKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERG 1430
               PV T S G KRKL   L+++G P ++LLDEPS+GMDP  ++ +WQ I    R     
Sbjct: 4850 ADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVRE-GCA 4908

Query: 1431 ALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHA 1490
            A+LT+H M E EA+C R+AIMV+G  +C+GS QH+K++FG  Y +++ +   A      +
Sbjct: 4909 AVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCTVS 4968

Query: 1491 EILRL-FPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQ 1549
            + L+L FP    + ++ +L+ Y +P +    LA  F  +E  K   +++ YS++Q+TLEQ
Sbjct: 4969 DHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNKTFLNIKHYSINQTTLEQ 5027

Query: 1550 VFLELSKEQELGDFEEDFDPS 1570
            VF+  + EQ+    +   DPS
Sbjct: 5028 VFINFASEQQ-QTLQSTLDPS 5047


>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
            sapiens]
          Length = 1704

 Score =  298 bits (762), Expect = 4e-80
 Identities = 280/1038 (26%), Positives = 477/1038 (45%), Gaps = 166/1038 (15%)

Query: 174  KEGFVALQAAINAAIIEITTNHSVME--ELMSVTGKNMKMHSFIGQSGVITDLYLFSCII 231
            +EGF+A+Q A++ AI+E   + +  +  + ++VT K      FI    ++   Y    ++
Sbjct: 208  REGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLL 267

Query: 232  SFSSFIY----YASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALV 287
              S F Y     A   V  + +R+K  M MMGL     W +W LL+  F+ I A F+ L+
Sbjct: 268  LLS-FTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLL 326

Query: 288  I-----RSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWG 342
                   +   +  S   +V +  L + +S ++ +F++S    K+ +       L  F  
Sbjct: 327  FCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTY 386

Query: 343  CLGF--TSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVA 400
               F     Y  +  S +    LLS  A  +G AQL+   ++            S + V 
Sbjct: 387  IPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMG-AQLIG-KFEAKGMGIQWRDLLSPVNVD 444

Query: 401  TNF-------MLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVAL 453
             +F       ML  D+ LY  +  Y E + P ++G  +P  FF+  S+W    +   VA 
Sbjct: 445  DDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRA--VAG 502

Query: 454  EDEMDADP--SFHDSFEQAPPEFQGKEAIRIRNVTKEYK-GKPDKIEALKDLVFDIYEGQ 510
            ++E D+DP  +  + + +A PE      I+I++++K ++ G  D+  A++DL  ++YEGQ
Sbjct: 503  KEEEDSDPEKALRNEYFEAEPE-DLVAGIKIKHLSKVFRVGNKDRA-AVRDLNLNLYEGQ 560

Query: 511  ITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQF 570
            IT +LGH+GAGK+T L++L+GL  PT G   I   ++S+  D+  + K  G+CPQ ++ F
Sbjct: 561  ITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ--DMVQIRKSLGLCPQHDILF 618

Query: 571  DFLTVRENLRLFAKIKGI----LPQEVDK------------------------------- 595
            D LTV E+L  +A++KG+     P+EV +                               
Sbjct: 619  DNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIA 678

Query: 596  -----EIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQ 650
                 ++ +LDEPT+G+D  SR  +W+LL+ +K+DR I+ +T FMDEAD+L DR   +++
Sbjct: 679  LIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAK 738

Query: 651  GKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTL 710
            G+L+C GSSLFLK+K+G GYH++L     C  E+I+ LV  H+P+A L + +  +L + L
Sbjct: 739  GELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFIL 798

Query: 711  PLERTNKFPELYKDLD-SYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILG---- 765
            P E T++F  L+  L+    +LGI ++G S+TT+ EVFL++ GK   +  DI  +     
Sbjct: 799  PRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRV-GKLVDSSMDIQAIQLPAL 857

Query: 766  EVQAEK-----------------ADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAI 808
            + Q E+                 +D    L+E E+    LN       G+AL  QQ  A+
Sbjct: 858  QYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNT------GLALHCQQFWAM 911

Query: 809  ARVRLLKLKHERKALLALLLI---------LMAGFCPLLVEYTMVKIYQNSY-------- 851
               +      E K + A +L+         L   +   L +  M+++    Y        
Sbjct: 912  FLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFS 971

Query: 852  -------TWELSPHL--YFLAPGQQPHDPLTQL--LIINKTGASIDDFIQSVEHQNIALE 900
                     +LS HL     A GQ+P + L  L   +I +       F    E   +A  
Sbjct: 972  VPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGF---NERCLVAAS 1028

Query: 901  VDAFGTRNGT----DDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGM 956
                G R       ++ +Y+   T      N  F L C        P    +VSN     
Sbjct: 1029 FRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCG-------PHASIVVSN----F 1077

Query: 957  VKPSVHIRTERSTFLENGQDNPIGF-LAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQL 1015
             +P   ++  +  F E  +   I   L + M +L  T S      + ++ +   +A+   
Sbjct: 1078 PQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFS------ILAVSERAVQAKHVQ 1131

Query: 1016 RISGLSPSAYWFGQALVDV------SLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCA 1069
             +SG+  +++W    L D+      SL  LV    + +   +    M  T++ ++     
Sbjct: 1132 FVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLL---- 1187

Query: 1070 VGYSFSLIFMTYVISFIF 1087
              Y +++I + Y+++F F
Sbjct: 1188 --YGWAIIPLMYLMNFFF 1203



 Score =  218 bits (555), Expect = 4e-56
 Identities = 133/352 (37%), Positives = 202/352 (57%), Gaps = 19/352 (5%)

Query: 1214 EDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCV 1273
            ED+DV  ER R   A +  +    P+II   L K Y         +R   +A   +S  V
Sbjct: 1357 EDQDVADERTRIL-APSPDSLLHTPLIIKE-LSKVY--------EQRVPLLAVDRLSLAV 1406

Query: 1274 RKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGYCPQENA 1329
            +KGE  GLLG NGAGK+T+ K++TG+   T+G   + G    S  G   + +GYCPQ +A
Sbjct: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDA 1466

Query: 1330 LWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFV 1389
            L  ++T R+ L +YA ++G+ +      +   +  L L+      V+T S G KRKL   
Sbjct: 1467 LLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTG 1526

Query: 1390 LSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVA 1449
            ++++G P+V+ LDEPSTGMDP  ++ +W  + A  R + +  ++T+H M E EA+C R+A
Sbjct: 1527 IALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITSHSMEECEALCTRLA 1585

Query: 1450 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLH---AEILRLFPQAARQERYS 1506
            IMV G+ +C+GS QHLKSKFG  Y L  KV++  Q E L    A +   FP +  ++ + 
Sbjct: 1586 IMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQ 1645

Query: 1507 SLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1558
             ++ Y LP  D+   A+ F  LEK K+ + +++YS+SQ +LEQVFL  +  Q
Sbjct: 1646 GMVHYHLPGRDLS-WAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696



 Score =  189 bits (481), Expect = 1e-47
 Identities = 157/599 (26%), Positives = 286/599 (47%), Gaps = 76/599 (12%)

Query: 999  IAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLL 1058
            IA + + + + R +  +R+ GLS   +W        S +FL+F F++L+   S      +
Sbjct: 278  IARAVVQEKERRLKEYMRMMGLSSWLHW--------SAWFLLF-FLFLLIAAS-----FM 323

Query: 1059 TIIHIIQIP---CAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFA-- 1113
            T++  +++      +  S   + + +++ F            SF F V T FS A  A  
Sbjct: 324  TLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAI-------STISFSFMVSTFFSKANMAAA 376

Query: 1114 ---FSIFESDIPFIFT-----FLIPPATMIGCLFLSSHLLFSSL----FSEERMDVQPFL 1161
               F  F + IP+ F      ++     +  CL  +  +   +     F  + M +Q + 
Sbjct: 377  FGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQ-WR 435

Query: 1162 VFLIP----------------FLHFIIFLFTLRCLEWKF-GKKSMRKDPFFRISPRSSDV 1204
              L P                 L  +++      +E  F G+  + +  +F I P  S  
Sbjct: 436  DLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMP--SYW 493

Query: 1205 CQNPEEPEG-EDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGK--RKGCFSKRK 1261
            C  P    G E+ED   E+     AL +  F+ +P  + + ++ ++  K  R G     K
Sbjct: 494  CGKPRAVAGKEEEDSDPEK-----ALRNEYFEAEPEDLVAGIKIKHLSKVFRVG----NK 544

Query: 1262 NKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDAL--- 1318
            ++ A R+++  + +G++  LLGHNGAGK+T++ ++TG   PT+G+  + G      +   
Sbjct: 545  DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQI 604

Query: 1319 -EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKT 1377
             + LG CPQ + L+ NLTV +HL  YA +KGL +      + +++  + L+D+  S  + 
Sbjct: 605  RKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRF 664

Query: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
            LS G++RKL   ++++    V++LDEP++GMD   ++ +W  ++   + ++R  +LTTH+
Sbjct: 665  LSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR--QKSDRTIVLTTHF 722

Query: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFP 1497
            M EA+ + DR+AIM  G L+C GS   LK K+G  Y + +  +     E +   +    P
Sbjct: 723  MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVP 782

Query: 1498 QAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSK 1556
             A  +    + + + LP E        F KLEK ++   +  +  S +T+E+VFL + K
Sbjct: 783  NATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841



 Score =  118 bits (296), Expect = 4e-26
 Identities = 142/610 (23%), Positives = 247/610 (40%), Gaps = 111/610 (18%)

Query: 226  LFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA 285
            LF+     S+F   A   V+    + K +  + G+  ++FWLS  LL+    F++   L 
Sbjct: 1105 LFAMAFLASTFSILA---VSERAVQAKHVQFVSGVHVASFWLS-ALLWDLISFLIPSLLL 1160

Query: 286  LVIRST---QFIILSGFMV-VFSLFLLYGLSLVALAFLMSI-----------LVKKSFLT 330
            LV+      +     G M     L LLYG +++ L +LM+            L   + L+
Sbjct: 1161 LVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILS 1220

Query: 331  GLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLD------YDLN 384
            G+  FL+               L  +L+ +  +L      LGMA     +      Y  +
Sbjct: 1221 GIATFLMVTIMRIPAVK--LEELSKTLDHVFLVLPNHC--LGMAVSSFYENYETRRYCTS 1276

Query: 385  SNAFPHPSDGSNLIVATNFM-------------LAFDTCLYLALAIYFEKILPNEYGHRR 431
            S    H     N+    NF              +A   C YL L    E  L        
Sbjct: 1277 SEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNL-------- 1328

Query: 432  PPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQ-----AP-PEFQGKEAIRIRNV 485
              L  L+    +  ++     L   M   P   D  ++     AP P+      + I+ +
Sbjct: 1329 --LQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKEL 1386

Query: 486  TKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNN 545
            +K Y+ +   + A+  L   + +G+   +LG +GAGK+T   +L+G    T G   +  +
Sbjct: 1387 SKVYEQRVPLL-AVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGH 1445

Query: 546  KLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEV------------ 593
            ++S  +D+  + +  G CPQ +   D +T RE L ++A+++GI  + +            
Sbjct: 1446 RIS--SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLL 1503

Query: 594  ----------------------------DKEIFLLDEPTAGLDPFSRHQVWNLL-KERKT 624
                                        +  +  LDEP+ G+DP +R  +W+ + + R++
Sbjct: 1504 LEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARES 1563

Query: 625  DRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVE-- 682
             + I+ ++  M+E + L  R   + QG+ KC GS   LK K+G GY L  ++     +  
Sbjct: 1564 GKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEA 1623

Query: 683  -ENITSLVKQHIPDAKLSAKSEGKLIYTLP---LERTNKFPELYKDLDSYPDLGIENYGV 738
             E   + V    P + L  + +G + Y LP   L     F  L K  + Y   G+++Y V
Sbjct: 1624 LEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKY---GVDDYSV 1680

Query: 739  SMTTLNEVFL 748
            S  +L +VFL
Sbjct: 1681 SQISLEQVFL 1690


>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
            sapiens]
          Length = 2261

 Score =  260 bits (665), Expect = 6e-69
 Identities = 231/827 (27%), Positives = 368/827 (44%), Gaps = 176/827 (21%)

Query: 176  GFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGV----------ITDLY 225
            GF  LQ  +  AII + T     E+   V  + M    ++    +          +T  +
Sbjct: 592  GFAYLQDVVEQAIIRVLTG---TEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAW 648

Query: 226  LFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA 285
            ++S  +     +Y        +  R+K  M +MGL +S  W SW +     + + A  L 
Sbjct: 649  IYSVAVIIKGIVY-------EKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLV 701

Query: 286  LVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVF------ 335
            ++++    +  S   VVF    ++ +  +   FL+S L  ++ L     G++ F      
Sbjct: 702  VILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPY 761

Query: 336  LLTVFW-GCLGFTSLYRHLPASLEWILSLLSPFAFMLGMA-------QLLHLDYDLNSNA 387
            +L V W   +GFT         L+   SLLSP AF  G         Q + + +D   N 
Sbjct: 762  VLCVAWQDYVGFT---------LKIFASLLSPVAFGFGCEYFALFEEQGIGVQWD---NL 809

Query: 388  FPHP--SDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFW--S 443
            F  P   DG NL  + + ML FDT LY  +  Y E + P +YG  RP  F    S+W   
Sbjct: 810  FESPVEEDGFNLTTSVSMML-FDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGE 868

Query: 444  QTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKD-L 502
            ++ +  H     +  ++       E+ P     K  + I+N+ K Y+   D ++   D L
Sbjct: 869  ESDEKSHPGSNQKRISEICM----EEEPTHL--KLGVSIQNLVKVYR---DGMKVAVDGL 919

Query: 503  VFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGV 562
              + YEGQIT+ LGH+GAGK+T ++IL+GL  PT G+  I    +   +++  + +  GV
Sbjct: 920  ALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDI--RSEMSTIRQNLGV 977

Query: 563  CPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE-------------------------- 596
            CPQ NV FD LTV E++  +A++KG+  + V  E                          
Sbjct: 978  CPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGM 1037

Query: 597  ---------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADIL 641
                           + +LDEPTAG+DP+SR  +W LL + +  R I+ ST  MDEAD+L
Sbjct: 1038 QRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVL 1097

Query: 642  ADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEI------CVEEN----------- 684
             DR   +S GKL C GSSLFLK + G GY+L+L   ++      C   +           
Sbjct: 1098 GDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDS 1157

Query: 685  -------------------------ITSLVKQHIPDAKLSAKSEGKLIYTLPLE--RTNK 717
                                     I++L+++H+ +A+L      +L Y LP E  +   
Sbjct: 1158 VSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGA 1217

Query: 718  FPELYKDLDS-YPDLGIENYGVSMTTLNEVFLKLEGKSTIN--ESDIAI--------LGE 766
            F EL+ ++D    DLGI +YG+S TTL E+FLK+  +S ++   SD  +         G+
Sbjct: 1218 FVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGD 1277

Query: 767  VQA--------EKADDTERLVEME----QVLSSLN-KMRKTIGGVALWRQQICAIARVRL 813
             Q+        + AD  +  ++ E     +LS ++ K    + G  L +QQ  A+   RL
Sbjct: 1278 KQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRL 1337

Query: 814  LKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPHLY 860
            L  +  RK   A +++     C  LV   +V  +    + EL P +Y
Sbjct: 1338 LIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMY 1384



 Score =  216 bits (551), Expect = 1e-55
 Identities = 174/604 (28%), Positives = 296/604 (49%), Gaps = 67/604 (11%)

Query: 993  SSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDV-------SLYFLVFVFIY 1045
            S  P    +  I +  ++A+    ISG+ P  YW    + D+       +L  ++F+   
Sbjct: 1666 SFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQ 1725

Query: 1046 LMSYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFR-KGRKNSGIWSFCFYVV 1104
              SY+S+    +L ++ ++       Y +S+  + Y  SF+F+        + S   ++ 
Sbjct: 1726 QKSYVSSTNLPVLALLLLL-------YGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIG 1778

Query: 1105 TVFSVAGFAFSIFE----SDIPFIF--TFLIPPATMIG---CLFLSSHLLFSSL--FSEE 1153
               SVA F   +F     ++I  I    FLI P   +G      + +  +  +L  F E 
Sbjct: 1779 INGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGEN 1838

Query: 1154 RM------DVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQN 1207
            R       D+    +F +     + FL T+  ++++           F I PR  +   +
Sbjct: 1839 RFVSPLSWDLVGRNLFAMAVEGVVFFLITV-LIQYR-----------FFIRPRPVNAKLS 1886

Query: 1208 PEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATR 1267
            P     EDEDV+ ER R  +        +  ++    L K Y         +RK K A  
Sbjct: 1887 P--LNDEDEDVRRERQRILD-----GGGQNDILEIKELTKIY---------RRKRKPAVD 1930

Query: 1268 NVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGY 1323
             +   +  GE  GLLG NGAGKS++ K++TGDT  T G   L      S   +  + +GY
Sbjct: 1931 RICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGY 1990

Query: 1324 CPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIK 1383
            CPQ +A+   LT R+H+E +A ++G+ + +        +  L L    +      S G K
Sbjct: 1991 CPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNK 2050

Query: 1384 RKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEA 1443
            RKL   ++++G P VV LDEP+TGMDP+ ++ +W    +  +   R  +LT+H M E EA
Sbjct: 2051 RKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKE-GRSVVLTSHSMEECEA 2109

Query: 1444 VCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVK-NLAQVEPLHAEILRLFPQAARQ 1502
            +C R+AIMV+GR RC+GS+QHLK++FG  Y + +++  +   ++P+       FP +  +
Sbjct: 2110 LCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLK 2169

Query: 1503 ERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGD 1562
            E++ +++ Y+LP   +  LA+ F  L + K+   +E+YS+SQ+TL+QVF+  +K+Q   D
Sbjct: 2170 EKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDD 2228

Query: 1563 FEED 1566
              +D
Sbjct: 2229 HLKD 2232



 Score =  151 bits (381), Expect = 6e-36
 Identities = 168/704 (23%), Positives = 297/704 (42%), Gaps = 130/704 (18%)

Query: 942  FPVLMDIVSNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAM 1001
            F  L D+V   ++ ++       TE+ T +   Q  P       +F  V++ S P ++ +
Sbjct: 593  FAYLQDVVEQAIIRVLTG-----TEKKTGVYM-QQMPYPCYVDDIFLRVMSRSMPLFMTL 646

Query: 1002 SSIDD---------YKNRARSQ--LRISGLSPSAYWFG---QALVDVSLYFLVFVFIYLM 1047
            + I           Y+  AR +  +RI GL  S  WF     +L+ + +   + V I  +
Sbjct: 647  AWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKL 706

Query: 1048 SYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNS---GIWSFCFYVV 1104
              +  + D  +  + +        ++   I   ++IS +F +    +   GI  F  Y+ 
Sbjct: 707  GNLLPYSDPSVVFVFLSV------FAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLP 760

Query: 1105 TVFSVA-----GFAFSIFESDIPFIFTFLIPPATMIGCLFLSSHLLFSSLFSEERMDVQP 1159
             V  VA     GF   IF S        L P A   GC + +       LF E+ + VQ 
Sbjct: 761  YVLCVAWQDYVGFTLKIFAS-------LLSPVAFGFGCEYFA-------LFEEQGIGVQW 806

Query: 1160 FLVFLIP-------------FLHFIIFLFTLRC--LEWKFGKKSMRKDPFFRISPRSSDV 1204
              +F  P              + F  FL+ +    +E  F  +     P++    +S   
Sbjct: 807  DNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWF 866

Query: 1205 CQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGK--RKGCFSKRKN 1262
                    GE+ D +         ++    +E+P  +   +  +   K  R G       
Sbjct: 867  --------GEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGM------ 912

Query: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDAL 1318
            K+A   ++    +G++   LGHNGAGK+T++ ++TG   PT+G   + G    S      
Sbjct: 913  KVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIR 972

Query: 1319 EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRL-VDALKLQDQLKSPVKT 1377
            + LG CPQ N L+  LTV +H+  YA +KGL +   +  + ++ +D      +LKS    
Sbjct: 973  QNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQ 1032

Query: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
            LS G++RKL   L+ +G   VV+LDEP+ G+DP  ++ +W+ +   +R   R  +L+TH+
Sbjct: 1033 LSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELL-LKYRQ-GRTIILSTHH 1090

Query: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNL--------------- 1482
            M EA+ + DR+AI+  G+L C+GS   LK++ G  Y L +  K++               
Sbjct: 1091 MDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVS 1150

Query: 1483 ---------------------------AQVEPLHAEILRLFPQAARQERYSSLMVYKLPV 1515
                                         V  +   I +   +A   E     + Y LP 
Sbjct: 1151 YLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPY 1210

Query: 1516 EDVQ--PLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKE 1557
            E  +     + F +++       +  Y +S++TLE++FL++++E
Sbjct: 1211 EAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEE 1254



 Score =  114 bits (284), Expect = 1e-24
 Identities = 125/590 (21%), Positives = 241/590 (40%), Gaps = 89/590 (15%)

Query: 223  DLYLFSCIISFSSFIYYASVNVTRERKRMKA--LMTMMGLRDSAFWLS---WGLLYAGFI 277
            D+ +  C+I   SF+  + V    + +  KA  L  + G++   +WLS   W +      
Sbjct: 1654 DVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVP 1713

Query: 278  FIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLL 337
              + + + +  +   ++  +   V+  L LLYG S+  L +  S + K      +V+  +
Sbjct: 1714 ATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSV 1773

Query: 338  TVFWGCLGFTSLY----------RHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNS-- 385
             +F G  G  + +           ++   L+ +  +   F    G+  ++      ++  
Sbjct: 1774 NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALE 1833

Query: 386  ----NAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSF 441
                N F  P    +L+    F +A +  ++  + +  +              FF++   
Sbjct: 1834 RFGENRFVSPLSW-DLVGRNLFAMAVEGVVFFLITVLIQY------------RFFIRP-- 1878

Query: 442  WSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKD 501
                 +  +  L    D D       ++        + + I+ +TK Y+ K  +  A+  
Sbjct: 1879 -----RPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRK--RKPAVDR 1931

Query: 502  LVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTG 561
            +   I  G+   +LG +GAGKS+   +L+G +  T+G   +  NK S ++++  + +  G
Sbjct: 1932 ICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFL--NKNSILSNIHEVHQNMG 1989

Query: 562  VCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK-------------------------- 595
             CPQ +   + LT RE++  FA ++G+  +EV K                          
Sbjct: 1990 YCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGN 2049

Query: 596  --------------EIFLLDEPTAGLDPFSRHQVWNL-LKERKTDRVILFSTQFMDEADI 640
                           +  LDEPT G+DP +R  +WN  L   K  R ++ ++  M+E + 
Sbjct: 2050 KRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEA 2109

Query: 641  LADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVE-ENITSLVKQHIPDAKLS 699
            L  R   +  G+ +C GS   LK ++G GY + +++     + + +        P + L 
Sbjct: 2110 LCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLK 2169

Query: 700  AKSEGKLIYTLPLERTNKFPELYKDL-DSYPDLGIENYGVSMTTLNEVFL 748
             K    L Y LP    +    ++  L  S   L IE+Y VS TTL++VF+
Sbjct: 2170 EKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218


>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
            [Homo sapiens]
          Length = 2436

 Score =  252 bits (644), Expect = 2e-66
 Identities = 234/864 (27%), Positives = 389/864 (45%), Gaps = 148/864 (17%)

Query: 18   KNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMD----------LGRV 67
            ++FL++ R+++   + WL   +  L L+    +  +++    L  D          L ++
Sbjct: 501  RSFLEQGRLQQH--LRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQL 558

Query: 68   DTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRV 127
            DT + +    +         Q M+KV+   F       G PDEESI  +T N   +    
Sbjct: 559  DTIDNAACGWI---------QFMSKVSVDIFK------GFPDEESIVNYTLNQAYQDNVT 603

Query: 128  TFTNTYSYHLKFLLGHGMPAKKEHK--DHTAHCYETNE--DVYCEVS------VFWKEGF 177
             F +      K      +P    +K   +++   +TNE    Y           ++  GF
Sbjct: 604  VFASVIFQTRK---DGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGF 660

Query: 178  VALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFI 237
            V +Q  +  AII+    H V+E    V       ++      VI  +     +IS+   +
Sbjct: 661  VWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSV 720

Query: 238  YYASVNVTRERK-RMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIIL 296
                 ++  E++ R+K +M  MGL ++  W++W +     + I    L  +++  Q ++ 
Sbjct: 721  AMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMH 780

Query: 297  SGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVFLLTVFWGCLGFTSLYRH 352
            S  ++++    +Y ++ +   FL+S+L  K+ L     G++ FL  V +  +       H
Sbjct: 781  SHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 840

Query: 353  --LPASLEWILSLLSPFAFMLGMAQL-------LHLDYDLNSNAFPHPSDGSNLIVATNF 403
              + A  + I SL+S  AF LG           + + +   S + P   D  NL++A   
Sbjct: 841  DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQS-PVEGDDFNLLLAVT- 898

Query: 404  MLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTD-------------- 449
            ML  D  +Y  L  Y E + P  YG  RP  F L+ S+W  + +T+              
Sbjct: 899  MLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRL 958

Query: 450  HVALEDEMDADPS--FHDS--FEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFD 505
             V  ED+  A  S  F ++   E+ P        + +  +TK Y  K DK  AL  L  +
Sbjct: 959  SVMEEDQACAMESRRFEETRGMEEEPTHL--PLVVCVDKLTKVY--KDDKKLALNKLSLN 1014

Query: 506  IYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQ 565
            +YE Q+ + LGH+GAGK+T ++IL+GL  PT GS TIY + +    +++ + K  G+CPQ
Sbjct: 1015 LYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDI--RTEMDEIRKNLGMCPQ 1072

Query: 566  SNVQFDFLTVRENLRLFAKIKGILPQEVDKEI---------------------------- 597
             NV FD LTV E+L  ++++K +  +E+ +E+                            
Sbjct: 1073 HNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKL 1132

Query: 598  ------------FLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRK 645
                         +LDEPTAG+DP++R  +W+L+ + K  R IL ST  MDEAD+L DR 
Sbjct: 1133 SVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRI 1192

Query: 646  VFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLN----------------------EICVEE 683
              +S GKLKC GS LFLK  +G GY L+L                           C E 
Sbjct: 1193 AIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSEL 1252

Query: 684  NITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNK--FPELYKDLD-SYPDLGIENYGVSM 740
             ++  +++H+    L + +  +L Y LP E   K  F  L++ L+ S   L + ++G+  
Sbjct: 1253 QVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMD 1312

Query: 741  TTLNEVFLKL--EGKSTIN-ESDI 761
            TTL EVFLK+  E +S  N E+D+
Sbjct: 1313 TTLEEVFLKVSEEDQSLENSEADV 1336



 Score =  239 bits (609), Expect = 2e-62
 Identities = 188/623 (30%), Positives = 304/623 (48%), Gaps = 82/623 (13%)

Query: 986  MFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL------ 1039
            +F +V  S  P    +  + +   +A+    +SG +P  YW    + D+  Y +      
Sbjct: 1797 IFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCV 1856

Query: 1040 VFVFIY-LMSYIS--NFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGI 1096
            + +F++ L +Y S  NF  +L   +          Y +S+  + Y  SF F      S  
Sbjct: 1857 IILFVFDLPAYTSPTNFPAVLSLFLL---------YGWSITPIMYPASFWFEVP---SSA 1904

Query: 1097 WSFCFYVVTVF-----SVAGFAFSIFESDIPFIFT-------FLIPPATMIGCLFLSSHL 1144
            + F   V+ +F     +VA F   +FE D             FLI P   +G   +   +
Sbjct: 1905 YVFLI-VINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLME--M 1961

Query: 1145 LFSSLFSEERMDVQPFLVFLIPFLHFII--------------FLFTLRCLEWKFGKKSMR 1190
             ++   +E    +  F     PF   I+              FL T+ C ++ F ++   
Sbjct: 1962 AYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMC-QYNFLRR--- 2017

Query: 1191 KDPFFRISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYA 1250
                    P+   V   P E   +D DV  ER R        + D   V I + L K Y 
Sbjct: 2018 --------PQRMPVSTKPVE---DDVDVASERQRVLRG----DADNDMVKIEN-LTKVYK 2061

Query: 1251 GKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLK 1310
             ++ G        +A   +   VR GE  GLLG NGAGK+++ K++TGD   T G+  + 
Sbjct: 2062 SRKIGRI------LAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVN 2115

Query: 1311 GSGGGDAL----EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALK 1366
            G      L    + LGYCPQ +AL+  LT R+HL++Y  ++G+   D    +   ++ L+
Sbjct: 2116 GHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLE 2175

Query: 1367 LQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRN 1426
            L      P  T S G KRKL   ++++G P+ + LDEP+TGMDP+ ++ +W  I    + 
Sbjct: 2176 LTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK- 2234

Query: 1427 TERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVE 1486
            T R  +LT+H M E EA+C R+AIMV+GRLRC+GSIQHLK++FG  Y++ ++ K+   V+
Sbjct: 2235 TGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVK 2294

Query: 1487 PLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQST 1546
             +     R FP+A  +ER+ + + Y+L  E +  LAQ F K+E+V     +E+YS+SQ+T
Sbjct: 2295 DVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKMEQVSGVLGIEDYSVSQTT 2353

Query: 1547 LEQVFLELSKEQELGDFEEDFDP 1569
            L+ VF+  +K+Q     +++ +P
Sbjct: 2354 LDNVFVNFAKKQSDNLEQQETEP 2376



 Score =  162 bits (410), Expect = 2e-39
 Identities = 114/352 (32%), Positives = 182/352 (51%), Gaps = 31/352 (8%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGG 1314
            K   K+A   +S  + + +V+  LGHNGAGK+T++ ++TG   PT+G   + G    +  
Sbjct: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060

Query: 1315 GDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSP 1374
             +  + LG CPQ N L+  LTV +HL  Y+ +K + + +    + ++++ L+L ++  S 
Sbjct: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1120

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
            V+TLS G+KRKL   ++ +G    ++LDEP+ G+DP  ++ +W  I        R  LL+
Sbjct: 1121 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLS 1178

Query: 1435 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------KVKNLAQ 1484
            TH+M EA+ + DR+AI+  G+L+C GS   LK  +G  Y L +          +   LA 
Sbjct: 1179 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1238

Query: 1485 VEPLHAEILRL----FPQAARQERYSSLMV--------YKLPVEDVQPLA--QAFFKLEK 1530
              P  A +         Q  R+   S L+V        Y LP E  +  A  + F  LE+
Sbjct: 1239 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1298

Query: 1531 VKQSFDLEEYSLSQSTLEQVFLELSKE-QELGDFEEDFDPSVKWKLLPQEEP 1581
               +  L  + L  +TLE+VFL++S+E Q L + E D   S K  L   E P
Sbjct: 1299 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGP 1350



 Score =  137 bits (344), Expect = 1e-31
 Identities = 151/634 (23%), Positives = 266/634 (41%), Gaps = 88/634 (13%)

Query: 185  NAAIIEIT-TNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISF--SSFIYYAS 241
            N A   IT TNH      M+ T  ++ +   +  + V+  +++   + SF  +SF+ +  
Sbjct: 1762 NPAAYGITVTNHP-----MNKTSASLSLDYLLQGTDVVIAIFIIVAM-SFVPASFVVFL- 1814

Query: 242  VNVTRERKRMKALMTMMGLRDSAFWLS---WGLLYAGFIFIMALFLALVIRSTQFIILSG 298
              V  +  + K L  + G     +WL+   W +L         + +  V     +   + 
Sbjct: 1815 --VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTN 1872

Query: 299  FMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTS-----LYRH- 352
            F  V SLFLLYG S+  + +  S   +      + + ++ +F G     +     L+ H 
Sbjct: 1873 FPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHD 1932

Query: 353  --LPASLEWILSLLSPFA-FMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDT 409
              L     ++ S    F  + LG   L+ + Y+   N + +   G    + + F     T
Sbjct: 1933 KDLKVVNSYLKSCFLIFPNYNLGHG-LMEMAYNEYINEY-YAKIGQFDKMKSPFEWDIVT 1990

Query: 410  CLYLALAIY----FEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHD 465
               +A+A+     F   +  +Y   R P          Q        +ED++D       
Sbjct: 1991 RGLVAMAVEGVVGFLLTIMCQYNFLRRP----------QRMPVSTKPVEDDVDVA----S 2036

Query: 466  SFEQAPPEFQGKEAIRIRNVTKEYKG-KPDKIEALKDLVFDIYEGQITAILGHSGAGKST 524
              ++        + ++I N+TK YK  K  +I A+  L   +  G+   +LG +GAGK++
Sbjct: 2037 ERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2096

Query: 525  LLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAK 584
               +L+G    T G   +  N  S + +L  + +  G CPQ +  FD LT RE+L+L+ +
Sbjct: 2097 TFKMLTGDESTTGGEAFV--NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTR 2154

Query: 585  IKGI-----------------LPQEVDKE-----------------------IFLLDEPT 604
            ++GI                 L +  DK                           LDEPT
Sbjct: 2155 LRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPT 2214

Query: 605  AGLDPFSRHQVWNLLKER-KTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLK 663
             G+DP +R  +WNL+ +  KT R ++ ++  M+E + L  R   +  G+L+C GS   LK
Sbjct: 2215 TGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLK 2274

Query: 664  KKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYK 723
             ++G GY ++++       +++     ++ P+A L  +   K+ Y L  E  +      K
Sbjct: 2275 NRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSK 2334

Query: 724  DLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTIN 757
                   LGIE+Y VS TTL+ VF+    K + N
Sbjct: 2335 MEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2368


>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
            [Homo sapiens]
          Length = 2466

 Score =  252 bits (644), Expect = 2e-66
 Identities = 234/864 (27%), Positives = 389/864 (45%), Gaps = 148/864 (17%)

Query: 18   KNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVNDFSSLLTMD----------LGRV 67
            ++FL++ R+++   + WL   +  L L+    +  +++    L  D          L ++
Sbjct: 531  RSFLEQGRLQQH--LRWLQQYVAELRLHPEALNLSLDELPPALRQDNFSLPSGMALLQQL 588

Query: 68   DTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRV 127
            DT + +    +         Q M+KV+   F       G PDEESI  +T N   +    
Sbjct: 589  DTIDNAACGWI---------QFMSKVSVDIFK------GFPDEESIVNYTLNQAYQDNVT 633

Query: 128  TFTNTYSYHLKFLLGHGMPAKKEHK--DHTAHCYETNE--DVYCEVS------VFWKEGF 177
             F +      K      +P    +K   +++   +TNE    Y           ++  GF
Sbjct: 634  VFASVIFQTRK---DGSLPPHVHYKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLYGF 690

Query: 178  VALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSFI 237
            V +Q  +  AII+    H V+E    V       ++      VI  +     +IS+   +
Sbjct: 691  VWIQDMMERAIIDTFVGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSV 750

Query: 238  YYASVNVTRERK-RMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIIL 296
                 ++  E++ R+K +M  MGL ++  W++W +     + I    L  +++  Q ++ 
Sbjct: 751  AMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMH 810

Query: 297  SGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVFLLTVFWGCLGFTSLYRH 352
            S  ++++    +Y ++ +   FL+S+L  K+ L     G++ FL  V +  +       H
Sbjct: 811  SHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 870

Query: 353  --LPASLEWILSLLSPFAFMLGMAQL-------LHLDYDLNSNAFPHPSDGSNLIVATNF 403
              + A  + I SL+S  AF LG           + + +   S + P   D  NL++A   
Sbjct: 871  DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQS-PVEGDDFNLLLAVT- 928

Query: 404  MLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTD-------------- 449
            ML  D  +Y  L  Y E + P  YG  RP  F L+ S+W  + +T+              
Sbjct: 929  MLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRL 988

Query: 450  HVALEDEMDADPS--FHDS--FEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFD 505
             V  ED+  A  S  F ++   E+ P        + +  +TK Y  K DK  AL  L  +
Sbjct: 989  SVMEEDQACAMESRRFEETRGMEEEPTHL--PLVVCVDKLTKVY--KDDKKLALNKLSLN 1044

Query: 506  IYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQ 565
            +YE Q+ + LGH+GAGK+T ++IL+GL  PT GS TIY + +    +++ + K  G+CPQ
Sbjct: 1045 LYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDI--RTEMDEIRKNLGMCPQ 1102

Query: 566  SNVQFDFLTVRENLRLFAKIKGILPQEVDKEI---------------------------- 597
             NV FD LTV E+L  ++++K +  +E+ +E+                            
Sbjct: 1103 HNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKL 1162

Query: 598  ------------FLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRK 645
                         +LDEPTAG+DP++R  +W+L+ + K  R IL ST  MDEAD+L DR 
Sbjct: 1163 SVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRI 1222

Query: 646  VFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLN----------------------EICVEE 683
              +S GKLKC GS LFLK  +G GY L+L                           C E 
Sbjct: 1223 AIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSEL 1282

Query: 684  NITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNK--FPELYKDLD-SYPDLGIENYGVSM 740
             ++  +++H+    L + +  +L Y LP E   K  F  L++ L+ S   L + ++G+  
Sbjct: 1283 QVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMD 1342

Query: 741  TTLNEVFLKL--EGKSTIN-ESDI 761
            TTL EVFLK+  E +S  N E+D+
Sbjct: 1343 TTLEEVFLKVSEEDQSLENSEADV 1366



 Score =  239 bits (609), Expect = 2e-62
 Identities = 188/623 (30%), Positives = 304/623 (48%), Gaps = 82/623 (13%)

Query: 986  MFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFL------ 1039
            +F +V  S  P    +  + +   +A+    +SG +P  YW    + D+  Y +      
Sbjct: 1827 IFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCV 1886

Query: 1040 VFVFIY-LMSYIS--NFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGI 1096
            + +F++ L +Y S  NF  +L   +          Y +S+  + Y  SF F      S  
Sbjct: 1887 IILFVFDLPAYTSPTNFPAVLSLFLL---------YGWSITPIMYPASFWFEVP---SSA 1934

Query: 1097 WSFCFYVVTVF-----SVAGFAFSIFESDIPFIFT-------FLIPPATMIGCLFLSSHL 1144
            + F   V+ +F     +VA F   +FE D             FLI P   +G   +   +
Sbjct: 1935 YVFLI-VINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLME--M 1991

Query: 1145 LFSSLFSEERMDVQPFLVFLIPFLHFII--------------FLFTLRCLEWKFGKKSMR 1190
             ++   +E    +  F     PF   I+              FL T+ C ++ F ++   
Sbjct: 1992 AYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAMAVEGVVGFLLTIMC-QYNFLRR--- 2047

Query: 1191 KDPFFRISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYA 1250
                    P+   V   P E   +D DV  ER R        + D   V I + L K Y 
Sbjct: 2048 --------PQRMPVSTKPVE---DDVDVASERQRVLRG----DADNDMVKIEN-LTKVYK 2091

Query: 1251 GKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLK 1310
             ++ G        +A   +   VR GE  GLLG NGAGK+++ K++TGD   T G+  + 
Sbjct: 2092 SRKIGRI------LAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVN 2145

Query: 1311 GSGGGDAL----EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALK 1366
            G      L    + LGYCPQ +AL+  LT R+HL++Y  ++G+   D    +   ++ L+
Sbjct: 2146 GHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLE 2205

Query: 1367 LQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRN 1426
            L      P  T S G KRKL   ++++G P+ + LDEP+TGMDP+ ++ +W  I    + 
Sbjct: 2206 LTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIK- 2264

Query: 1427 TERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVE 1486
            T R  +LT+H M E EA+C R+AIMV+GRLRC+GSIQHLK++FG  Y++ ++ K+   V+
Sbjct: 2265 TGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVK 2324

Query: 1487 PLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQST 1546
             +     R FP+A  +ER+ + + Y+L  E +  LAQ F K+E+V     +E+YS+SQ+T
Sbjct: 2325 DVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKMEQVSGVLGIEDYSVSQTT 2383

Query: 1547 LEQVFLELSKEQELGDFEEDFDP 1569
            L+ VF+  +K+Q     +++ +P
Sbjct: 2384 LDNVFVNFAKKQSDNLEQQETEP 2406



 Score =  162 bits (410), Expect = 2e-39
 Identities = 114/352 (32%), Positives = 182/352 (51%), Gaps = 31/352 (8%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGG 1314
            K   K+A   +S  + + +V+  LGHNGAGK+T++ ++TG   PT+G   + G    +  
Sbjct: 1031 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1090

Query: 1315 GDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSP 1374
             +  + LG CPQ N L+  LTV +HL  Y+ +K + + +    + ++++ L+L ++  S 
Sbjct: 1091 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSL 1150

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
            V+TLS G+KRKL   ++ +G    ++LDEP+ G+DP  ++ +W  I        R  LL+
Sbjct: 1151 VQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILK--YKPGRTILLS 1208

Query: 1435 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------KVKNLAQ 1484
            TH+M EA+ + DR+AI+  G+L+C GS   LK  +G  Y L +          +   LA 
Sbjct: 1209 THHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLAS 1268

Query: 1485 VEPLHAEILRL----FPQAARQERYSSLMV--------YKLPVEDVQPLA--QAFFKLEK 1530
              P  A +         Q  R+   S L+V        Y LP E  +  A  + F  LE+
Sbjct: 1269 SPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLER 1328

Query: 1531 VKQSFDLEEYSLSQSTLEQVFLELSKE-QELGDFEEDFDPSVKWKLLPQEEP 1581
               +  L  + L  +TLE+VFL++S+E Q L + E D   S K  L   E P
Sbjct: 1329 SLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGP 1380



 Score =  137 bits (344), Expect = 1e-31
 Identities = 151/634 (23%), Positives = 266/634 (41%), Gaps = 88/634 (13%)

Query: 185  NAAIIEIT-TNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISF--SSFIYYAS 241
            N A   IT TNH      M+ T  ++ +   +  + V+  +++   + SF  +SF+ +  
Sbjct: 1792 NPAAYGITVTNHP-----MNKTSASLSLDYLLQGTDVVIAIFIIVAM-SFVPASFVVFL- 1844

Query: 242  VNVTRERKRMKALMTMMGLRDSAFWLS---WGLLYAGFIFIMALFLALVIRSTQFIILSG 298
              V  +  + K L  + G     +WL+   W +L         + +  V     +   + 
Sbjct: 1845 --VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTN 1902

Query: 299  FMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGFTS-----LYRH- 352
            F  V SLFLLYG S+  + +  S   +      + + ++ +F G     +     L+ H 
Sbjct: 1903 FPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHD 1962

Query: 353  --LPASLEWILSLLSPFA-FMLGMAQLLHLDYDLNSNAFPHPSDGSNLIVATNFMLAFDT 409
              L     ++ S    F  + LG   L+ + Y+   N + +   G    + + F     T
Sbjct: 1963 KDLKVVNSYLKSCFLIFPNYNLGHG-LMEMAYNEYINEY-YAKIGQFDKMKSPFEWDIVT 2020

Query: 410  CLYLALAIY----FEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHD 465
               +A+A+     F   +  +Y   R P          Q        +ED++D       
Sbjct: 2021 RGLVAMAVEGVVGFLLTIMCQYNFLRRP----------QRMPVSTKPVEDDVDVA----S 2066

Query: 466  SFEQAPPEFQGKEAIRIRNVTKEYKG-KPDKIEALKDLVFDIYEGQITAILGHSGAGKST 524
              ++        + ++I N+TK YK  K  +I A+  L   +  G+   +LG +GAGK++
Sbjct: 2067 ERQRVLRGDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTS 2126

Query: 525  LLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAK 584
               +L+G    T G   +  N  S + +L  + +  G CPQ +  FD LT RE+L+L+ +
Sbjct: 2127 TFKMLTGDESTTGGEAFV--NGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTR 2184

Query: 585  IKGI-----------------LPQEVDKE-----------------------IFLLDEPT 604
            ++GI                 L +  DK                           LDEPT
Sbjct: 2185 LRGISWKDEARVVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPT 2244

Query: 605  AGLDPFSRHQVWNLLKER-KTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLK 663
             G+DP +R  +WNL+ +  KT R ++ ++  M+E + L  R   +  G+L+C GS   LK
Sbjct: 2245 TGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLK 2304

Query: 664  KKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYK 723
             ++G GY ++++       +++     ++ P+A L  +   K+ Y L  E  +      K
Sbjct: 2305 NRFGDGYMITVRTKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSK 2364

Query: 724  DLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTIN 757
                   LGIE+Y VS TTL+ VF+    K + N
Sbjct: 2365 MEQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2398


>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
            [Homo sapiens]
          Length = 2277

 Score =  236 bits (602), Expect = 1e-61
 Identities = 176/662 (26%), Positives = 312/662 (47%), Gaps = 88/662 (13%)

Query: 177  FVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSF 236
            F+ LQ +I  AIIE+ T  +  E  ++V  + +    F+  + + +  Y    ++  +  
Sbjct: 703  FIYLQDSIERAIIELQTGRNSQE--IAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWV 760

Query: 237  IYYASVN---VTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQF 293
            ++ A+     V  +  R+   M MMG+   + + +W +   GF+ +  + L ++++    
Sbjct: 761  VFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNI 820

Query: 294  IILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTV--FWGCLGFTSLYR 351
            +  +   ++F  F  Y  S++A+++L+S+    + +  L+  L+ +  F+  +   ++  
Sbjct: 821  LPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVEN 880

Query: 352  HLPASLEWILSLLSPFAFMLGMAQLLHLDYD------LNSNAFPHPSDGSNLIVATNFML 405
             L   L+  +SLLSP AF      +   +         N    P   D ++       +L
Sbjct: 881  ELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLIL 940

Query: 406  AFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQT--------QKTDHVALEDEM 457
            A D+ +Y  +A Y   + P  YG   P  F +  S+W +         +K++ +   + M
Sbjct: 941  A-DSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIM 999

Query: 458  ------DADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQI 511
                   A P +  S    P        + +  VTK Y  K     A+ +L  + YEG I
Sbjct: 1000 MQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKV----AVDNLNLNFYEGHI 1055

Query: 512  TAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFD 571
            T++LG +GAGK+T +++L+GL   + G++ +Y   +    DL  + K  GVC Q +V F 
Sbjct: 1056 TSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGVCMQHDVLFS 1113

Query: 572  FLTVRENLRLFAKI------KGILPQEVDK------------------------------ 595
            +LT +E+L L+  I      K  L +EV +                              
Sbjct: 1114 YLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISI 1173

Query: 596  ------EIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLS 649
                   + +LDEP+ G+DP SR  +W+++ + KT R I+ ST  +DEA++L+DR  FL 
Sbjct: 1174 ALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLE 1233

Query: 650  QGKLKCAGSSLFLKKKWGIGYHL--------SLQLNEICVEENITSLVKQHIPDAKLSAK 701
            QG L+C GS  +LK+ +G GYHL        +L  N +C    +T++++ H+P+A L   
Sbjct: 1234 QGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKED 1293

Query: 702  SEGKLIYTLP---LERTNKFPELYKDLDS-YPDLGIENYGVSMTTLNEVFLKLEGKSTIN 757
              G+L+Y LP    + +  +  L + LD+   DL I  YG+S TT+ EVFL L  +S  N
Sbjct: 1294 IGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1353

Query: 758  ES 759
             +
Sbjct: 1354 SA 1355



 Score =  226 bits (576), Expect = 1e-58
 Identities = 177/609 (29%), Positives = 298/609 (48%), Gaps = 60/609 (9%)

Query: 982  LAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVF 1041
            L+ +M + V T+S   Y+    + +++ +A+    ISG+  + YW    + D+  Y +  
Sbjct: 1673 LSILMGYSVTTASFVTYV----VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPV 1728

Query: 1042 VF----IYLMSYISNFEDMLLTIIHIIQIPCAVGYS-FS-------------LIFMTYVI 1083
             F    I +    + + +  L  + ++ +    GY+ FS             + F+TYV 
Sbjct: 1729 AFSIGIIAIFKLPAFYSENNLGAVSLLLL--LFGYATFSWMYLLAGLFHETGMAFITYVC 1786

Query: 1084 SFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSH 1143
              +F     NS +     Y ++          +    +  IF          G + LS  
Sbjct: 1787 VNLFFG--INSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQ 1844

Query: 1144 L-------LFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFR 1196
                     +   +  E  ++       +  +      F+LR L  +   K +R   FFR
Sbjct: 1845 QSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL--FFR 1902

Query: 1197 ISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGC 1256
                SS V     E   EDEDV+ ER+R  +   +  FD   ++   CL K Y       
Sbjct: 1903 -KFNSSHV----RETIDEDEDVRAERLRVESG--AAEFD---LVQLYCLTKTYQ------ 1946

Query: 1257 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGG- 1315
                K  IA  N+S  +  GE  GLLG NGAGK+T  K++TGD  P++G +L++   G  
Sbjct: 1947 -LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSL 2005

Query: 1316 ----DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQL 1371
                     +GYCPQE+AL   +TV +HL  YA V G+ + D +  + +L+  L L    
Sbjct: 2006 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFK 2065

Query: 1372 KSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGA 1431
                   S G KRKL   L+++G PS++LLDEPS+GMDP+ ++ +W+ I    +N +   
Sbjct: 2066 DRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSV 2124

Query: 1432 LLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAE 1491
            +LT+H M E EA+C R+AIMV+G+ +CIGS+QH+KS+FG+ + +++ +KN         +
Sbjct: 2125 ILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTK 2184

Query: 1492 ILRL-FPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQV 1550
             ++L FP+   ++++ S++ Y +PV     +A  F  LE  K + ++  + +SQ+TLE+V
Sbjct: 2185 FMQLHFPKTYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEV 2243

Query: 1551 FLELSKEQE 1559
            F+  +K+Q+
Sbjct: 2244 FINFAKDQK 2252



 Score =  159 bits (403), Expect = 2e-38
 Identities = 152/596 (25%), Positives = 270/596 (45%), Gaps = 67/596 (11%)

Query: 1010 RARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCA 1069
            R    +++ G++  +++F   +  V    +  V + +   I  F ++L      I     
Sbjct: 777  RLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILII---ILKFGNILPKTNGFILFLYF 833

Query: 1070 VGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIF---ESDIPFIF- 1125
              YSFS+I M+Y+IS  F      + I S       ++ +A F F +    E+++ ++  
Sbjct: 834  SDYSFSVIAMSYLISVFFNNTNIAALIGSL------IYIIAFFPFIVLVTVENELSYVLK 887

Query: 1126 ---TFLIPPATMIGCLFLSSH------LLFSSLF-SEERMDVQPF-----LVFLIPFLHF 1170
               + L P A      +++ +      L + +++ S  + D   F     L+    F++F
Sbjct: 888  VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 947

Query: 1171 IIFLFTLRCLEWKFGKKSMRKDPFFRISP-----RSSDVCQNPEEPEG-EDEDVQMERVR 1224
            +I  +        +G   M    +F I P     R       PE+  G    ++ M+   
Sbjct: 948  LIAWYVRNVFPGTYG---MAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTN 1004

Query: 1225 TANA---LNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGL 1281
             + +   + S+N + +P  +   +      K  G      +K+A  N++    +G +  L
Sbjct: 1005 PSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYG------SKVAVDNLNLNFYEGHITSL 1058

Query: 1282 LGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF----LGYCPQENALWPNLTVR 1337
            LG NGAGK+T+I ++TG    +AG + + G      L      +G C Q + L+  LT +
Sbjct: 1059 LGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTK 1118

Query: 1338 QHLEVYAAVK--GLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGN 1395
            +HL +Y ++K     K      + R +    L       V TLS G+KRKL   ++++G 
Sbjct: 1119 EHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGG 1178

Query: 1396 PSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGR 1455
              VV+LDEPSTG+DP  ++ +W  I  +   T R  +L+TH++ EAE + DR+A +  G 
Sbjct: 1179 SRVVILDEPSTGVDPCSRRSIWDVI--SKNKTARTIILSTHHLDEAEVLSDRIAFLEQGG 1236

Query: 1456 LRCIGSIQHLKSKFGKDYLLEMKVKN--------LAQVEPLHAEILRLFPQAARQERYSS 1507
            LRC GS  +LK  FG  Y L +  K         +     + A I    P+A  +E    
Sbjct: 1237 LRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGG 1296

Query: 1508 LMVYKLPVEDVQPLAQAFFKLEKVKQS----FDLEEYSLSQSTLEQVFLELSKEQE 1559
             +VY LP    + ++ A+  L +   +     ++  Y +S +T+E+VFL L+KE +
Sbjct: 1297 ELVYVLPPFSTK-VSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ 1351



 Score =  140 bits (353), Expect = 1e-32
 Identities = 147/638 (23%), Positives = 273/638 (42%), Gaps = 109/638 (17%)

Query: 218  SGVITDLYLFSCIISFS----SFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLY 273
            S +I  L   S ++ +S    SF+ Y    V   + + K L  + G+  + +W++     
Sbjct: 1664 SSLIDILVALSILMGYSVTTASFVTYV---VREHQTKAKQLQHISGIGVTCYWVT----- 1715

Query: 274  AGFIFIMALFLALVIRSTQFIILSGFMVVFS---------LFLLYGLSLVALAFLMSILV 324
              FI+ M  +L  V  S   I +      +S         L LL+G +  +  +L++ L 
Sbjct: 1716 -NFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLF 1774

Query: 325  KKSFLTGLVVFLLTVFWGCLGFTSL---------------YRHLPASLEWILSLLSPFAF 369
             ++ +  +    + +F+G     SL                  +  +L+ I  +   F F
Sbjct: 1775 HETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCF 1834

Query: 370  MLGMAQLLH----LDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE-KILP 424
              G+ +L      LD+ L +    +P++   +    N + A    L     ++F  ++L 
Sbjct: 1835 GYGLIELSQQQSVLDF-LKAYGVEYPNETFEM----NKLGAMFVALVSQGTMFFSLRLLI 1889

Query: 425  NEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHD-SFEQAPPEFQGKEAIRIR 483
            NE   ++  LFF K +       + HV    + D D        E    EF   + +++ 
Sbjct: 1890 NESLIKKLRLFFRKFN-------SSHVRETIDEDEDVRAERLRVESGAAEF---DLVQLY 1939

Query: 484  NVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIY 543
             +TK Y+    KI A+ ++   I  G+   +LG +GAGK+T+  +L+G  +P+ G++ I 
Sbjct: 1940 CLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILI- 1998

Query: 544  NNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK-------- 595
             NK   +  +++ S L G CPQ +   D +TV E+L  +A++ GI  +++ +        
Sbjct: 1999 RNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRR 2058

Query: 596  --------------------------------EIFLLDEPTAGLDPFSRHQVWNLLKERK 623
                                             I LLDEP++G+DP S+  +W ++ E  
Sbjct: 2059 LHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEV 2118

Query: 624  TDRV-ILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQL-NEICV 681
             ++  ++ ++  M+E + L  R   +  GK +C GS   +K ++G G+ + + L N    
Sbjct: 2119 QNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVT 2178

Query: 682  EENITSLVKQHIPDAKLSAKSEGKLIYTLPLER---TNKFPELYKDLDSYPDLGIENYGV 738
             E +T  ++ H P   L  +    L Y +P+      N F  L  +  +   L I N+ V
Sbjct: 2179 METLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTA---LNITNFLV 2235

Query: 739  SMTTLNEVFLKL-EGKSTINESDIAILGE-VQAEKADD 774
            S TTL EVF+   + + +   +D +  G  +  +  DD
Sbjct: 2236 SQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDD 2273


>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
            [Homo sapiens]
          Length = 2595

 Score =  236 bits (602), Expect = 1e-61
 Identities = 176/662 (26%), Positives = 312/662 (47%), Gaps = 88/662 (13%)

Query: 177  FVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSSF 236
            F+ LQ +I  AIIE+ T  +  E  ++V  + +    F+  + + +  Y    ++  +  
Sbjct: 1021 FIYLQDSIERAIIELQTGRNSQE--IAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWV 1078

Query: 237  IYYASVN---VTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQF 293
            ++ A+     V  +  R+   M MMG+   + + +W +   GF+ +  + L ++++    
Sbjct: 1079 VFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNI 1138

Query: 294  IILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTV--FWGCLGFTSLYR 351
            +  +   ++F  F  Y  S++A+++L+S+    + +  L+  L+ +  F+  +   ++  
Sbjct: 1139 LPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVEN 1198

Query: 352  HLPASLEWILSLLSPFAFMLGMAQLLHLDYD------LNSNAFPHPSDGSNLIVATNFML 405
             L   L+  +SLLSP AF      +   +         N    P   D ++       +L
Sbjct: 1199 ELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLIL 1258

Query: 406  AFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQT--------QKTDHVALEDEM 457
            A D+ +Y  +A Y   + P  YG   P  F +  S+W +         +K++ +   + M
Sbjct: 1259 A-DSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIM 1317

Query: 458  ------DADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQI 511
                   A P +  S    P        + +  VTK Y  K     A+ +L  + YEG I
Sbjct: 1318 MQNTNPSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKV----AVDNLNLNFYEGHI 1373

Query: 512  TAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFD 571
            T++LG +GAGK+T +++L+GL   + G++ +Y   +    DL  + K  GVC Q +V F 
Sbjct: 1374 TSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGVCMQHDVLFS 1431

Query: 572  FLTVRENLRLFAKI------KGILPQEVDK------------------------------ 595
            +LT +E+L L+  I      K  L +EV +                              
Sbjct: 1432 YLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISI 1491

Query: 596  ------EIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLS 649
                   + +LDEP+ G+DP SR  +W+++ + KT R I+ ST  +DEA++L+DR  FL 
Sbjct: 1492 ALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLE 1551

Query: 650  QGKLKCAGSSLFLKKKWGIGYHL--------SLQLNEICVEENITSLVKQHIPDAKLSAK 701
            QG L+C GS  +LK+ +G GYHL        +L  N +C    +T++++ H+P+A L   
Sbjct: 1552 QGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKED 1611

Query: 702  SEGKLIYTLP---LERTNKFPELYKDLDS-YPDLGIENYGVSMTTLNEVFLKLEGKSTIN 757
              G+L+Y LP    + +  +  L + LD+   DL I  YG+S TT+ EVFL L  +S  N
Sbjct: 1612 IGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKN 1671

Query: 758  ES 759
             +
Sbjct: 1672 SA 1673



 Score =  226 bits (576), Expect = 1e-58
 Identities = 177/609 (29%), Positives = 298/609 (48%), Gaps = 60/609 (9%)

Query: 982  LAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVF 1041
            L+ +M + V T+S   Y+    + +++ +A+    ISG+  + YW    + D+  Y +  
Sbjct: 1991 LSILMGYSVTTASFVTYV----VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPV 2046

Query: 1042 VF----IYLMSYISNFEDMLLTIIHIIQIPCAVGYS-FS-------------LIFMTYVI 1083
             F    I +    + + +  L  + ++ +    GY+ FS             + F+TYV 
Sbjct: 2047 AFSIGIIAIFKLPAFYSENNLGAVSLLLL--LFGYATFSWMYLLAGLFHETGMAFITYVC 2104

Query: 1084 SFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATMIGCLFLSSH 1143
              +F     NS +     Y ++          +    +  IF          G + LS  
Sbjct: 2105 VNLFFG--INSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQ 2162

Query: 1144 L-------LFSSLFSEERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFR 1196
                     +   +  E  ++       +  +      F+LR L  +   K +R   FFR
Sbjct: 2163 QSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLRL--FFR 2220

Query: 1197 ISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGC 1256
                SS V     E   EDEDV+ ER+R  +   +  FD   ++   CL K Y       
Sbjct: 2221 -KFNSSHV----RETIDEDEDVRAERLRVESG--AAEFD---LVQLYCLTKTYQ------ 2264

Query: 1257 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGG- 1315
                K  IA  N+S  +  GE  GLLG NGAGK+T  K++TGD  P++G +L++   G  
Sbjct: 2265 -LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSL 2323

Query: 1316 ----DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQL 1371
                     +GYCPQE+AL   +TV +HL  YA V G+ + D +  + +L+  L L    
Sbjct: 2324 GHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFK 2383

Query: 1372 KSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGA 1431
                   S G KRKL   L+++G PS++LLDEPS+GMDP+ ++ +W+ I    +N +   
Sbjct: 2384 DRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN-KCSV 2442

Query: 1432 LLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAE 1491
            +LT+H M E EA+C R+AIMV+G+ +CIGS+QH+KS+FG+ + +++ +KN         +
Sbjct: 2443 ILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTK 2502

Query: 1492 ILRL-FPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQV 1550
             ++L FP+   ++++ S++ Y +PV     +A  F  LE  K + ++  + +SQ+TLE+V
Sbjct: 2503 FMQLHFPKTYLKDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEV 2561

Query: 1551 FLELSKEQE 1559
            F+  +K+Q+
Sbjct: 2562 FINFAKDQK 2570



 Score =  159 bits (403), Expect = 2e-38
 Identities = 152/596 (25%), Positives = 270/596 (45%), Gaps = 67/596 (11%)

Query: 1010 RARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCA 1069
            R    +++ G++  +++F   +  V    +  V + +   I  F ++L      I     
Sbjct: 1095 RLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILII---ILKFGNILPKTNGFILFLYF 1151

Query: 1070 VGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIF---ESDIPFIF- 1125
              YSFS+I M+Y+IS  F      + I S       ++ +A F F +    E+++ ++  
Sbjct: 1152 SDYSFSVIAMSYLISVFFNNTNIAALIGSL------IYIIAFFPFIVLVTVENELSYVLK 1205

Query: 1126 ---TFLIPPATMIGCLFLSSH------LLFSSLF-SEERMDVQPF-----LVFLIPFLHF 1170
               + L P A      +++ +      L + +++ S  + D   F     L+    F++F
Sbjct: 1206 VFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYF 1265

Query: 1171 IIFLFTLRCLEWKFGKKSMRKDPFFRISP-----RSSDVCQNPEEPEG-EDEDVQMERVR 1224
            +I  +        +G   M    +F I P     R       PE+  G    ++ M+   
Sbjct: 1266 LIAWYVRNVFPGTYG---MAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTN 1322

Query: 1225 TANA---LNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGL 1281
             + +   + S+N + +P  +   +      K  G      +K+A  N++    +G +  L
Sbjct: 1323 PSASPEYMFSSNIEPEPKDLTVGVALHGVTKIYG------SKVAVDNLNLNFYEGHITSL 1376

Query: 1282 LGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF----LGYCPQENALWPNLTVR 1337
            LG NGAGK+T+I ++TG    +AG + + G      L      +G C Q + L+  LT +
Sbjct: 1377 LGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTK 1436

Query: 1338 QHLEVYAAVK--GLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGN 1395
            +HL +Y ++K     K      + R +    L       V TLS G+KRKL   ++++G 
Sbjct: 1437 EHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGG 1496

Query: 1396 PSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGR 1455
              VV+LDEPSTG+DP  ++ +W  I  +   T R  +L+TH++ EAE + DR+A +  G 
Sbjct: 1497 SRVVILDEPSTGVDPCSRRSIWDVI--SKNKTARTIILSTHHLDEAEVLSDRIAFLEQGG 1554

Query: 1456 LRCIGSIQHLKSKFGKDYLLEMKVKN--------LAQVEPLHAEILRLFPQAARQERYSS 1507
            LRC GS  +LK  FG  Y L +  K         +     + A I    P+A  +E    
Sbjct: 1555 LRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGG 1614

Query: 1508 LMVYKLPVEDVQPLAQAFFKLEKVKQS----FDLEEYSLSQSTLEQVFLELSKEQE 1559
             +VY LP    + ++ A+  L +   +     ++  Y +S +T+E+VFL L+KE +
Sbjct: 1615 ELVYVLPPFSTK-VSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQ 1669



 Score =  140 bits (353), Expect = 1e-32
 Identities = 147/638 (23%), Positives = 273/638 (42%), Gaps = 109/638 (17%)

Query: 218  SGVITDLYLFSCIISFS----SFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLY 273
            S +I  L   S ++ +S    SF+ Y    V   + + K L  + G+  + +W++     
Sbjct: 1982 SSLIDILVALSILMGYSVTTASFVTYV---VREHQTKAKQLQHISGIGVTCYWVT----- 2033

Query: 274  AGFIFIMALFLALVIRSTQFIILSGFMVVFS---------LFLLYGLSLVALAFLMSILV 324
              FI+ M  +L  V  S   I +      +S         L LL+G +  +  +L++ L 
Sbjct: 2034 -NFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLF 2092

Query: 325  KKSFLTGLVVFLLTVFWGCLGFTSL---------------YRHLPASLEWILSLLSPFAF 369
             ++ +  +    + +F+G     SL                  +  +L+ I  +   F F
Sbjct: 2093 HETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCF 2152

Query: 370  MLGMAQLLH----LDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFE-KILP 424
              G+ +L      LD+ L +    +P++   +    N + A    L     ++F  ++L 
Sbjct: 2153 GYGLIELSQQQSVLDF-LKAYGVEYPNETFEM----NKLGAMFVALVSQGTMFFSLRLLI 2207

Query: 425  NEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHD-SFEQAPPEFQGKEAIRIR 483
            NE   ++  LFF K +       + HV    + D D        E    EF   + +++ 
Sbjct: 2208 NESLIKKLRLFFRKFN-------SSHVRETIDEDEDVRAERLRVESGAAEF---DLVQLY 2257

Query: 484  NVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIY 543
             +TK Y+    KI A+ ++   I  G+   +LG +GAGK+T+  +L+G  +P+ G++ I 
Sbjct: 2258 CLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILI- 2316

Query: 544  NNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK-------- 595
             NK   +  +++ S L G CPQ +   D +TV E+L  +A++ GI  +++ +        
Sbjct: 2317 RNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRR 2376

Query: 596  --------------------------------EIFLLDEPTAGLDPFSRHQVWNLLKERK 623
                                             I LLDEP++G+DP S+  +W ++ E  
Sbjct: 2377 LHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEV 2436

Query: 624  TDRV-ILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQL-NEICV 681
             ++  ++ ++  M+E + L  R   +  GK +C GS   +K ++G G+ + + L N    
Sbjct: 2437 QNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVT 2496

Query: 682  EENITSLVKQHIPDAKLSAKSEGKLIYTLPLER---TNKFPELYKDLDSYPDLGIENYGV 738
             E +T  ++ H P   L  +    L Y +P+      N F  L  +  +   L I N+ V
Sbjct: 2497 METLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTA---LNITNFLV 2553

Query: 739  SMTTLNEVFLKL-EGKSTINESDIAILGE-VQAEKADD 774
            S TTL EVF+   + + +   +D +  G  +  +  DD
Sbjct: 2554 SQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDD 2591


>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
            sapiens]
          Length = 2273

 Score =  224 bits (572), Expect = 4e-58
 Identities = 183/685 (26%), Positives = 309/685 (45%), Gaps = 125/685 (18%)

Query: 176  GFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSS 235
            GF  LQ  +   I   T +    E  + +  + M    F+  S +I    L  C   F  
Sbjct: 607  GFAYLQDMVEQGI---TRSQVQAEAPVGIYLQQMPYPCFVDDSFMII---LNRCFPIFMV 660

Query: 236  FIYYASVNVT------RERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIR 289
              +  SV++T       +  R+K  +   G+ ++  W +W L     + +    L + I 
Sbjct: 661  LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM 720

Query: 290  STQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLV--VFLLTVFWGCLGFT 347
              + +  S   ++F   L +  + + L FL+S    K+ L      V   T++   +   
Sbjct: 721  HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF 780

Query: 348  SLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYD------LNSNAFPHPSDGSNLIVAT 401
            +    + A L+  +SLLSP AF  G   L+  +         N    P   D  + +++ 
Sbjct: 781  AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSM 840

Query: 402  NFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFW-----------SQTQKTDH 450
              ML  D  +Y  LA Y +++ P +YG   P  F L+ S+W              +KT+ 
Sbjct: 841  QMML-LDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP 899

Query: 451  VALEDEMDADPS-FHDSF-EQAPPEFQGKEAIRIRNVTKEYK--GKPDKIEALKDLVFDI 506
            +  E E    P   HDSF E+  P +     + ++N+ K ++  G+P    A+  L    
Sbjct: 900  LTEETEDPEHPEGIHDSFFEREHPGWV--PGVCVKNLVKIFEPCGRP----AVDRLNITF 953

Query: 507  YEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQS 566
            YE QITA LGH+GAGK+T L+IL+GL  PT G+V +    +     L+ + +  G+CPQ 
Sbjct: 954  YENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIE--TSLDAVRQSLGMCPQH 1011

Query: 567  NVQFDFLTVRENLRLFAKIKGILPQEV--------------------------------- 593
            N+ F  LTV E++  +A++KG   +E                                  
Sbjct: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLS 1071

Query: 594  -------DKEIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKV 646
                   D ++ +LDEPT+G+DP+SR  +W+LL + ++ R I+ ST  MDEAD+L DR  
Sbjct: 1072 VAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIA 1131

Query: 647  FLSQGKLKCAGSSLFLKKKWGIGYHLSL-------------------------------Q 675
             ++QG+L C+G+ LFLK  +G G +L+L                                
Sbjct: 1132 IIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAH 1191

Query: 676  LNEICVEE-------NITSLVKQHIPDAKLSAKSEGKLIYTLPLE--RTNKFPELYKDL- 725
            ++++  E+        +  +V  H+P+AKL      +LI+ LP +  +   +  L+++L 
Sbjct: 1192 VDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELE 1251

Query: 726  DSYPDLGIENYGVSMTTLNEVFLKL 750
            ++  DLG+ ++G+S T L E+FLK+
Sbjct: 1252 ETLADLGLSSFGISDTPLEEIFLKV 1276



 Score =  219 bits (557), Expect = 2e-56
 Identities = 180/600 (30%), Positives = 287/600 (47%), Gaps = 72/600 (12%)

Query: 993  SSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLY-----FLVFVFIYLM 1047
            S  P    +  I +  N+++    ISG+SP+ YW    L D+  Y      +V +FI   
Sbjct: 1691 SFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQ 1750

Query: 1048 SYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVF 1107
                   + L  ++ ++ +     Y +++I M Y  SF+F          S     + + 
Sbjct: 1751 KKAYTSPENLPALVALLLL-----YGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGIN 1805

Query: 1108 SVA-GFAFSIFESDIPFI-FTFLIPPATMIGCLFLSSHLLFSSLFSEERMDV-------- 1157
            S A  F   +FE++   + F  ++    ++   F     L     S+   DV        
Sbjct: 1806 SSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEH 1865

Query: 1158 --QPFL-------VFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNP 1208
               PF        +F +     + FL TL           + +  FF     S  + +  
Sbjct: 1866 SANPFHWDLIGKNLFAMVVEGVVYFLLTL-----------LVQRHFFL----SQWIAEPT 1910

Query: 1209 EEP-EGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATR 1267
            +EP   ED+DV  ER R     N T+     ++    L K Y G          +  A  
Sbjct: 1911 KEPIVDEDDDVAEERQRIITGGNKTD-----ILRLHELTKIYPGT---------SSPAVD 1956

Query: 1268 NVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGY 1323
             +   VR GE  GLLG NGAGK+T+ K++TGDT  T+G   + G    +   +  + +GY
Sbjct: 1957 RLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGY 2016

Query: 1324 CPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIK 1383
            CPQ +A+   LT R+HL +YA ++G+   + E      + +L L         T S G K
Sbjct: 2017 CPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNK 2076

Query: 1384 RKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEA 1443
            RKL   ++++G P +VLLDEP+TGMDP+ ++ +W  I +  R   R  +LT+H M E EA
Sbjct: 2077 RKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIRE-GRAVVLTSHSMEECEA 2135

Query: 1444 VCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKN-----LAQVEPLHAEILRLFPQ 1498
            +C R+AIMV G  RC+G+IQHLKSKFG  Y++ MK+K+     L  + P+       FP 
Sbjct: 2136 LCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPG 2195

Query: 1499 AARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1558
            + ++ER+ +++ +++       LA+ F  L   K S  +EEYS++Q+TL+QVF+  +K+Q
Sbjct: 2196 SVQRERHYNMLQFQV---SSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQ 2252



 Score =  153 bits (386), Expect = 1e-36
 Identities = 114/403 (28%), Positives = 197/403 (48%), Gaps = 56/403 (13%)

Query: 1213 GEDEDVQMERV--RTANALNSTNFDEKPV-IIASCLRKEYAGKRKGCFSKRKNKI----- 1264
            GE    + ER   +T      T   E P  I  S   +E+ G   G   K   KI     
Sbjct: 883  GEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCG 942

Query: 1265 --ATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF-- 1320
              A   ++    + ++   LGHNGAGK+T++ ++TG   PT+G VL+ G     +L+   
Sbjct: 943  RPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVR 1002

Query: 1321 --LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTL 1378
              LG CPQ N L+ +LTV +H+  YA +KG  + +A++ +  +++   L  +     + L
Sbjct: 1003 QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDL 1062

Query: 1379 SEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYM 1438
            S G++RKL   ++ +G+  VV+LDEP++G+DP  ++ +W  +      + R  +++TH+M
Sbjct: 1063 SGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLK--YRSGRTIIMSTHHM 1120

Query: 1439 AEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM--KVKNL-------------- 1482
             EA+ + DR+AI+  GRL C G+   LK+ FG    L +  K+KN+              
Sbjct: 1121 DEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCS 1180

Query: 1483 ---------AQVEPLHAE-------------ILRLFPQAARQERYSSLMVYKLPVEDVQP 1520
                     A V+ L  E             +L   P+A   E     +++ LP ++ + 
Sbjct: 1181 SKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKH 1240

Query: 1521 LAQA--FFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELG 1561
             A A  F +LE+      L  + +S + LE++FL+++++ + G
Sbjct: 1241 RAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSG 1283



 Score =  106 bits (265), Expect = 2e-22
 Identities = 118/607 (19%), Positives = 242/607 (39%), Gaps = 105/607 (17%)

Query: 220  VITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLS---WGLLYAGF 276
            V+    +FS     +SF+ Y    +     + K L  + G+  + +W++   W ++    
Sbjct: 1681 VVAICVIFSMSFVPASFVLYL---IQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSV 1737

Query: 277  IFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFL 336
               + + + +  +   +        + +L LLYG +++ + +  S L        + +  
Sbjct: 1738 SAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSC 1797

Query: 337  LTVFWGCLGFTSLY-----------RHLPASLEWILSLLSPFAFMLGMAQLL-------- 377
              +F G       +               A L  +L +   F    G+  L         
Sbjct: 1798 ANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDV 1857

Query: 378  --HLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLF 435
                  + ++N F     G NL     F +  +  +Y  L +  ++             F
Sbjct: 1858 YARFGEEHSANPFHWDLIGKNL-----FAMVVEGVVYFLLTLLVQRH------------F 1900

Query: 436  FLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDK 495
            FL       T+       E  +D D    +  ++        + +R+  +TK Y G    
Sbjct: 1901 FLSQWIAEPTK-------EPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSP 1953

Query: 496  IEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLEN 555
              A+  L   +  G+   +LG +GAGK+T   +L+G +  T G  T+    +  + ++  
Sbjct: 1954 --AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSI--LTNISE 2009

Query: 556  LSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK-------------------- 595
            + +  G CPQ +   + LT RE+L L+A+++G+  +E++K                    
Sbjct: 2010 VHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAG 2069

Query: 596  --------------------EIFLLDEPTAGLDPFSRHQVWNLLKER-KTDRVILFSTQF 634
                                 + LLDEPT G+DP +R  +WN++    +  R ++ ++  
Sbjct: 2070 TYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHS 2129

Query: 635  MDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQL----NEICVEEN-ITSLV 689
            M+E + L  R   + +G  +C G+   LK K+G GY +++++    +++  + N +    
Sbjct: 2130 MEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFF 2189

Query: 690  KQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPD-LGIENYGVSMTTLNEVFL 748
            + + P +    +    L + +    ++    +++ L S+ D L IE Y V+ TTL++VF+
Sbjct: 2190 QGNFPGSVQRERHYNMLQFQV---SSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFV 2246

Query: 749  KLEGKST 755
                + T
Sbjct: 2247 NFAKQQT 2253


>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
            sapiens]
          Length = 2146

 Score =  224 bits (572), Expect = 4e-58
 Identities = 219/800 (27%), Positives = 344/800 (43%), Gaps = 140/800 (17%)

Query: 176  GFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGV---ITDLYLFSCIIS 232
            GFV LQ  +  A + +            ++G N +   ++ Q      + D++L     S
Sbjct: 502  GFVYLQDLVERAAVRV------------LSGANPRAGLYLQQMPYPCYVDDVFLRVLSRS 549

Query: 233  FSSFIYYA---SVNVT-----RERK-RMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALF 283
               F+  A   SV +T     RE++ R++  M  MGL  +  WL W L   G   + A  
Sbjct: 550  LPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAAL 609

Query: 284  LALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT----GLVVFLLTV 339
            L LV++    +  S   VVF     + ++ V  +FL+S    ++ L     GL  F L +
Sbjct: 610  LVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYL 669

Query: 340  -FWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNS----NAFPHPSDG 394
             +  C+ +      LPA      SLLSP AF  G   L  L+         N    P+  
Sbjct: 670  PYVLCVAWRD---RLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTAD 726

Query: 395  SNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALE 454
               +   + +L  D  LY     Y E + P +YG   P  F  + S+W   +     A  
Sbjct: 727  VFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPA-P 785

Query: 455  DEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAI 514
                 DP      E+APP       + +R++ K + G P    AL+ L  D Y+G ITA 
Sbjct: 786  CPTPLDPKV--LVEEAPPGLS--PGVSVRSLEKRFPGSPQP--ALRGLSLDFYQGHITAF 839

Query: 515  LGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLT 574
            LGH+GAGK+T L+ILSGL  P+ GS  I  + +   + +  +    GVCPQ NV FD LT
Sbjct: 840  LGHNGAGKTTTLSILSGLFPPSGGSAFILGHDV--RSSMAAIRPHLGVCPQYNVLFDMLT 897

Query: 575  VRENLRLFAKIKGI-----------LPQEV-----------------------------D 594
            V E++  + ++KG+           L Q+V                              
Sbjct: 898  VDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGG 957

Query: 595  KEIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLK 654
             ++ +LDEPTAG+DP SR  +W LL + +  R ++ ST  +DEA++L DR   ++ G+L 
Sbjct: 958  SQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLC 1017

Query: 655  CAGSSLFLKKKWGIGYHLSLQLNEICVEEN------------------------------ 684
            C GS LFL++  G GY+L+L    + +  N                              
Sbjct: 1018 CCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQ 1077

Query: 685  ITSLVKQHIPDAKLSAKSEGKLIYTLPL--ERTNKFPELYKDLDS-YPDLGIENYGVSMT 741
            + +LV+  +P A+L  +   +L+  LP        F  L+++LD+   +L +  YG+S T
Sbjct: 1078 LLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDT 1137

Query: 742  TLNEVFLKLEGKSTINE------------SDIAILGEVQAEKADDTERLVEMEQVLSSLN 789
            +L E+FLK+  +   +             + IA L      K    E  +E  +   S  
Sbjct: 1138 SLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAP 1197

Query: 790  KMRKTIG--------GVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEY 841
            +  +  G        G AL RQQ+ A+   R L  +  R+ L A  ++L A F  L + +
Sbjct: 1198 ETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFA-QIVLPALFVGLALVF 1256

Query: 842  TMVKIYQNSY-TWELSPHLY 860
            +++      Y    LSP +Y
Sbjct: 1257 SLIVPPFGHYPALRLSPTMY 1276



 Score =  214 bits (545), Expect = 5e-55
 Identities = 178/606 (29%), Positives = 280/606 (46%), Gaps = 88/606 (14%)

Query: 993  SSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYF-------LVFVFIY 1045
            S  P    +  I++   RA+    + GLSP+ YW G  L D+  Y        L+F+   
Sbjct: 1547 SFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQ 1606

Query: 1046 LMSYIS--NFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYV 1103
              +Y++  N   +LL ++          Y +S+  + Y  SF F        + S  + V
Sbjct: 1607 QRAYVAPANLPALLLLLLL---------YGWSITPLMYPASFFF-------SVPSTAYVV 1650

Query: 1104 VTVF--------SVAGFAFSIFES----DIPFIF--TFLIPPATMIGCLFLSSHLLFSSL 1149
            +T          S+A F   +F      ++  I    FLI P   +G   +      +  
Sbjct: 1651 LTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMA 1710

Query: 1150 FSEERMDVQPF-------------LVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFR 1196
             + ER+  + F             L  +I    F++F   L+       +  +   P  R
Sbjct: 1711 DAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQ------HRSQLLPQPRVR 1764

Query: 1197 ISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGC 1256
              P   +          EDEDV  ER R        +     V++   L K Y G+R   
Sbjct: 1765 SLPLLGE----------EDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMP- 1808

Query: 1257 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSG--- 1313
                    A   +   +  GE  GLLG NGAGK+++ +++TGDT  + G+ +L G     
Sbjct: 1809 --------AVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR 1860

Query: 1314 -GGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLK 1372
                A   +GYCPQ +A++  LT R+HLE+ A ++G+ +          +  L L     
Sbjct: 1861 EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYAD 1920

Query: 1373 SPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGAL 1432
             P  T S G KRKL   L+++G+P+VV LDEP+TGMDP  ++ +W ++ A  R   R  +
Sbjct: 1921 RPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREG-RSVM 1979

Query: 1433 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEI 1492
            LT+H M E EA+C R+AIMV+GR RC+GS QHLK +F   + L ++V   A+ +P  A +
Sbjct: 1980 LTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVP-AARSQPAAAFV 2038

Query: 1493 LRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFL 1552
               FP A  +E +   + ++LP      LA+ F +L        +E++S+SQ+ LE+VFL
Sbjct: 2039 AAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFL 2098

Query: 1553 ELSKEQ 1558
              SK+Q
Sbjct: 2099 YFSKDQ 2104



 Score =  133 bits (334), Expect = 2e-30
 Identities = 103/364 (28%), Positives = 165/364 (45%), Gaps = 51/364 (14%)

Query: 1265 ATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALE----F 1320
            A R +S    +G +   LGHNGAGK+T++ +++G   P+ G   + G     ++      
Sbjct: 823  ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPH 882

Query: 1321 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSE 1380
            LG CPQ N L+  LTV +H+  Y  +KGL          RL+  + L  +     + LS 
Sbjct: 883  LGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSG 942

Query: 1381 GIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAE 1440
            G++RKL   ++ +G   VV+LDEP+ G+DP  ++ +W+ +   +R   R  +L+TH++ E
Sbjct: 943  GMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL-LKYRE-GRTLILSTHHLDE 1000

Query: 1441 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM----------------------- 1477
            AE + DRVA++  GRL C GS   L+   G  Y L +                       
Sbjct: 1001 AELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDT 1060

Query: 1478 --KVKNLAQ-----VEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQ--PLAQAFFKL 1528
              + KN +Q        L A +    P A   E     +V  LP         A  F +L
Sbjct: 1061 RQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFREL 1120

Query: 1529 EKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEED-------------FDPSVKWKL 1575
            +       L  Y +S ++LE++FL++ +E       ED              D +++ K+
Sbjct: 1121 DTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKM 1180

Query: 1576 LPQE 1579
             PQE
Sbjct: 1181 PPQE 1184



 Score =  128 bits (322), Expect = 4e-29
 Identities = 140/608 (23%), Positives = 252/608 (41%), Gaps = 103/608 (16%)

Query: 223  DLYLFSCIISFSSFIYYASVNVTRERK--RMKALMTMMGLRDSAFWLS---WGLLYAGFI 277
            D+ +  C++   SF+  +   V  E +  R K L  M GL  + +WL    W +      
Sbjct: 1535 DVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVP 1594

Query: 278  FIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLL 337
              + + + L  +   ++  +    +  L LLYG S+  L +  S          +V+  +
Sbjct: 1595 ACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCI 1654

Query: 338  TVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFPHPSDGSNL 397
             +F G  G  + +         +L L S       ++++L   + +    FPH   G  L
Sbjct: 1655 NLFIGINGSMATF---------VLELFSDQKLQ-EVSRILKQVFLI----FPHFCLGRGL 1700

Query: 398  IVATNFMLAFDTCLYLALAIYFEKILPNEYGHR---------------RPPLFFLKSSFW 442
            I         D     A+A  FE++   ++                  + PLF L   F 
Sbjct: 1701 I---------DMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLL---FT 1748

Query: 443  SQTQKTDHVALEDEMDADPSFHDSFEQAPPE----FQGK---EAIRIRNVTKEYKGKPDK 495
               Q    +  +  + + P   +  E    E     QG    + + +RN+TK Y+G+  +
Sbjct: 1749 LLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQ--R 1806

Query: 496  IEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLEN 555
            + A+  L   I  G+   +LG +GAGK++   +++G ++ ++G   +  + ++      +
Sbjct: 1807 MPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAH 1866

Query: 556  LSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEV---------------------- 593
            LS   G CPQS+  F+ LT RE+L L A+++G+   +V                      
Sbjct: 1867 LSM--GYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924

Query: 594  ------------------DKEIFLLDEPTAGLDPFSRHQVWN-LLKERKTDRVILFSTQF 634
                              D  +  LDEPT G+DP +R  +WN LL   +  R ++ ++  
Sbjct: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984

Query: 635  MDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIP 694
            M+E + L  R   +  G+ +C GS   LK ++  G+ L+L++      +   + V    P
Sbjct: 1985 MEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV-PAARSQPAAAFVAAEFP 2043

Query: 695  DAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSY-PDLGIENYGVSMTTLNEVFL---KL 750
             A+L     G+L + LP         ++ +L  +  + G+E++ VS T L EVFL   K 
Sbjct: 2044 GAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKD 2103

Query: 751  EGKSTINE 758
            +GK    E
Sbjct: 2104 QGKDEDTE 2111


>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
          Length = 171

 Score =  124 bits (310), Expect = 9e-28
 Identities = 59/164 (35%), Positives = 102/164 (62%), Gaps = 1/164 (0%)

Query: 1334 LTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSIL 1393
            +T ++ + +YA + G+ +    + + + +++L+L+      + T SEG KR+L   ++++
Sbjct: 1    MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60

Query: 1394 GNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1453
            G  SV+ LDEPSTGMDP  ++ +W  +  T R + +  ++T+H M E +A+C  +AIMV 
Sbjct: 61   GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119

Query: 1454 GRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFP 1497
            G+  C+GS QHLKSKFG  Y+L++KVK   ++E     +   FP
Sbjct: 120  GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 1/81 (1%)

Query: 597 IFLLDEPTAGLDPFSRHQVWNLL-KERKTDRVILFSTQFMDEADILADRKVFLSQGKLKC 655
           +  LDEP+ G+DP +R  +WN++ K R++ + I+ ++  M+E D L      + QGK  C
Sbjct: 65  VIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQGKFTC 124

Query: 656 AGSSLFLKKKWGIGYHLSLQL 676
            GS   LK K+G  Y L +++
Sbjct: 125 LGSPQHLKSKFGNIYILKVKV 145


>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
          Length = 171

 Score =  124 bits (310), Expect = 9e-28
 Identities = 59/164 (35%), Positives = 102/164 (62%), Gaps = 1/164 (0%)

Query: 1334 LTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSIL 1393
            +T ++ + +YA + G+ +    + + + +++L+L+      + T SEG KR+L   ++++
Sbjct: 1    MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60

Query: 1394 GNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1453
            G  SV+ LDEPSTGMDP  ++ +W  +  T R + +  ++T+H M E +A+C  +AIMV 
Sbjct: 61   GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119

Query: 1454 GRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFP 1497
            G+  C+GS QHLKSKFG  Y+L++KVK   ++E     +   FP
Sbjct: 120  GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 1/81 (1%)

Query: 597 IFLLDEPTAGLDPFSRHQVWNLL-KERKTDRVILFSTQFMDEADILADRKVFLSQGKLKC 655
           +  LDEP+ G+DP +R  +WN++ K R++ + I+ ++  M+E D L      + QGK  C
Sbjct: 65  VIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQGKFTC 124

Query: 656 AGSSLFLKKKWGIGYHLSLQL 676
            GS   LK K+G  Y L +++
Sbjct: 125 LGSPQHLKSKFGNIYILKVKV 145


>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
          Length = 171

 Score =  124 bits (310), Expect = 9e-28
 Identities = 59/164 (35%), Positives = 102/164 (62%), Gaps = 1/164 (0%)

Query: 1334 LTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSIL 1393
            +T ++ + +YA + G+ +    + + + +++L+L+      + T SEG KR+L   ++++
Sbjct: 1    MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60

Query: 1394 GNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1453
            G  SV+ LDEPSTGMDP  ++ +W  +  T R + +  ++T+H M E +A+C  +AIMV 
Sbjct: 61   GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119

Query: 1454 GRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFP 1497
            G+  C+GS QHLKSKFG  Y+L++KVK   ++E     +   FP
Sbjct: 120  GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 1/81 (1%)

Query: 597 IFLLDEPTAGLDPFSRHQVWNLL-KERKTDRVILFSTQFMDEADILADRKVFLSQGKLKC 655
           +  LDEP+ G+DP +R  +WN++ K R++ + I+ ++  M+E D L      + QGK  C
Sbjct: 65  VIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQGKFTC 124

Query: 656 AGSSLFLKKKWGIGYHLSLQL 676
            GS   LK K+G  Y L +++
Sbjct: 125 LGSPQHLKSKFGNIYILKVKV 145


>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sapiens]
          Length = 673

 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 59/221 (26%), Positives = 114/221 (51%), Gaps = 15/221 (6%)

Query: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITG---DTKPTAGQVLLKGSGGGDAL- 1318
            ++  +N+SF VR G++L ++G +G G+++ + VITG     K  +GQ+ + G      L 
Sbjct: 85   ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144

Query: 1319 -EFLGYCPQENALWPNLTVRQHLEVYAAVKGLR---KGDAEVAITRLVDALKLQDQLKSP 1374
             + + +  Q N L PNLTVR+ L   A ++  R   +   +  +  ++  L+L+    + 
Sbjct: 145  RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204

Query: 1375 -----VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTER 1429
                 V+ LS G +R++   + +L NP +++LDEP++G+D      + + + +      R
Sbjct: 205  VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTL-SRLAKGNR 263

Query: 1430 GALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1469
              L++ H   ++   + D V +M SG    +G+ QH+   F
Sbjct: 264  LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 68/288 (23%), Positives = 120/288 (41%), Gaps = 66/288 (22%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTK-GSVTIYNNKLSEMADLENLS 557
           +++L F +  GQ+ AI+G SG G+++LL++++G     K  S  I+ N   + +  + + 
Sbjct: 88  IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWIN--GQPSSPQLVR 145

Query: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQ-----EVDKE---------------- 596
           K      Q N     LTVRE L   A+++  LP+     + DK                 
Sbjct: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMR--LPRTFSQAQRDKRVEDVIAELRLRQCADT 203

Query: 597 -----------------------------IFLLDEPTAGLDPFSRHQ-VWNLLKERKTDR 626
                                        I +LDEPT+GLD F+ H  V  L +  K +R
Sbjct: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263

Query: 627 VILFSTQFMDEADI--LADRKVFLSQGKLKCAGSSLFLKKKW-GIGYHLSLQLNEICVEE 683
           ++L S      +DI  L D  + ++ G     G++  + + +  IGY      N      
Sbjct: 264 LVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYV 322

Query: 684 NITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELY-----KDLD 726
           ++TS + +   + +L+ + + + +  L LE+     +       KDLD
Sbjct: 323 DLTS-IDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLD 369


>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
            sapiens]
          Length = 646

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 61/224 (27%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 1249 YAGKRKGCFSKRKNKIATRNVS--FCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAG 1305
            Y+ +   C+ KR  K   + +S  FC R  E++G++G +GAGKST + ++ G  +    G
Sbjct: 68   YSVREGPCWRKRGYKTLLKCLSGKFCRR--ELIGIMGPSGAGKSTFMNILAGYRESGMKG 125

Query: 1306 QVLLKGSGGG--DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVA-ITRLV 1362
            Q+L+ G         +   Y  Q++ L P+LTV + + V A +K   K + +   +T ++
Sbjct: 126  QILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEIL 185

Query: 1363 DALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRA 1422
             AL L     +    LS G +++L   L ++ NP V+  DEP++G+D     Q+   +++
Sbjct: 186  TALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245

Query: 1423 TFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
              +   R  + T H   A+   + D++ I+  G+    G + +L
Sbjct: 246  LAQG-GRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNL 288



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 48/186 (25%), Positives = 71/186 (38%), Gaps = 46/186 (24%)

Query: 510 QITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQ 569
           ++  I+G SGAGKST +NIL+G          + N +  E   L    K++    Q ++ 
Sbjct: 96  ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRE---LRTFRKMSCYIMQDDML 152

Query: 570 FDFLTVRENLRLFAKIKGILPQEVDKE--------------------------------- 596
              LTV E + + A +K    QEV KE                                 
Sbjct: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212

Query: 597 --------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADI--LADRKV 646
                   +   DEPT+GLD  S  QV +L+K        +  T     A +  + D+  
Sbjct: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLY 272

Query: 647 FLSQGK 652
            LSQG+
Sbjct: 273 ILSQGQ 278


>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
            sapiens]
          Length = 646

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 61/224 (27%), Positives = 113/224 (50%), Gaps = 10/224 (4%)

Query: 1249 YAGKRKGCFSKRKNKIATRNVS--FCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAG 1305
            Y+ +   C+ KR  K   + +S  FC R  E++G++G +GAGKST + ++ G  +    G
Sbjct: 68   YSVREGPCWRKRGYKTLLKCLSGKFCRR--ELIGIMGPSGAGKSTFMNILAGYRESGMKG 125

Query: 1306 QVLLKGSGGG--DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVA-ITRLV 1362
            Q+L+ G         +   Y  Q++ L P+LTV + + V A +K   K + +   +T ++
Sbjct: 126  QILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEIL 185

Query: 1363 DALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRA 1422
             AL L     +    LS G +++L   L ++ NP V+  DEP++G+D     Q+   +++
Sbjct: 186  TALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKS 245

Query: 1423 TFRNTERGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
              +   R  + T H   A+   + D++ I+  G+    G + +L
Sbjct: 246  LAQG-GRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNL 288



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 48/186 (25%), Positives = 71/186 (38%), Gaps = 46/186 (24%)

Query: 510 QITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQ 569
           ++  I+G SGAGKST +NIL+G          + N +  E   L    K++    Q ++ 
Sbjct: 96  ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRE---LRTFRKMSCYIMQDDML 152

Query: 570 FDFLTVRENLRLFAKIKGILPQEVDKE--------------------------------- 596
              LTV E + + A +K    QEV KE                                 
Sbjct: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212

Query: 597 --------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADI--LADRKV 646
                   +   DEPT+GLD  S  QV +L+K        +  T     A +  + D+  
Sbjct: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLY 272

Query: 647 FLSQGK 652
            LSQG+
Sbjct: 273 ILSQGQ 278


>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
            sapiens]
          Length = 1464

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 59/205 (28%), Positives = 104/205 (50%), Gaps = 22/205 (10%)

Query: 1265 ATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF---- 1320
            A   V+FCV+ GE LG++G  G+GKS+ + V+    +P++G+VLL G      LE     
Sbjct: 1234 ALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQ-LELAQLR 1292

Query: 1321 --LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDA------EVAITRLVDAL-KLQDQL 1371
              L   PQE  L+   TVR++L+     +GL K  A      +  ++ ++ ++  L  +L
Sbjct: 1293 SQLAIIPQEPFLFSG-TVRENLD----PQGLHKDRALWQALKQCHLSEVITSMGGLDGEL 1347

Query: 1372 KSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGA 1431
                ++LS G ++ LC   ++L +  ++ +DE +  +D +  Q + Q I   F N     
Sbjct: 1348 GEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANK---T 1404

Query: 1432 LLTTHYMAEAEAVCDRVAIMVSGRL 1456
            +LT  +        DRV ++ +GR+
Sbjct: 1405 VLTIAHRLNTILNSDRVLVLQAGRV 1429



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 49/194 (25%), Positives = 83/194 (42%), Gaps = 24/194 (12%)

Query: 1273 VRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQENALWP 1332
            V+KG ++G++G  G GKS+ +  I G+     G V ++G   G      G   QE   W 
Sbjct: 595  VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG-----FGLATQEP--WI 647

Query: 1333 NL-TVRQHL--------EVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIK 1383
               T+R ++        ++Y  V      + +++I    D    Q ++     TLS G +
Sbjct: 648  QFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGD----QTEVGEKGVTLSGGQR 703

Query: 1384 RKLCFVLSILGNPSVVLLDEPSTGMDPE-GQQQMWQAIRATFRNTERGALLTTHYMAEAE 1442
             ++    ++     + LLD+P   +D +     + + I      T R  LL TH     E
Sbjct: 704  ARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR--LLCTHRTEYLE 761

Query: 1443 AVCDRVAIMVSGRL 1456
               D V +M +GRL
Sbjct: 762  R-ADAVLLMEAGRL 774



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 30/88 (34%), Positives = 45/88 (51%), Gaps = 2/88 (2%)

Query: 492  KPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMA 551
            +P    AL  + F +  G+   I+G +G+GKS+LL +L  L  P+ G V +     S++ 
Sbjct: 1228 RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQL- 1286

Query: 552  DLENLSKLTGVCPQSNVQFDFLTVRENL 579
            +L  L     + PQ    F   TVRENL
Sbjct: 1287 ELAQLRSQLAIIPQEPFLFSG-TVRENL 1313



 Score = 31.6 bits (70), Expect = 6.4
 Identities = 24/80 (30%), Positives = 38/80 (47%), Gaps = 13/80 (16%)

Query: 505 DIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCP 564
           ++ +G +  I+G  G GKS+LL  ++G     +G V +             LSK  G+  
Sbjct: 594 EVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAV-----------RGLSKGFGLAT 642

Query: 565 QSNVQFDFLTVRENLRLFAK 584
           Q      F T+R+N+ LF K
Sbjct: 643 Q-EPWIQFATIRDNI-LFGK 660


>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
            sapiens]
          Length = 808

 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 58/229 (25%), Positives = 101/229 (44%), Gaps = 21/229 (9%)

Query: 1257 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----- 1311
            +  R + +  + ++F +R GEV  L+G NG+GKST   ++    +PT GQ+LL G     
Sbjct: 572  YPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ 631

Query: 1312 ----------SGGGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRL 1361
                      +  G   +  G   QEN  +  LT +  +E   A     K  A   I+ L
Sbjct: 632  YEHRYLHRQVAAVGQEPQVFGRSLQENIAY-GLTQKPTMEEITA--AAVKSGAHSFISGL 688

Query: 1362 VDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIR 1421
                    ++      LS G ++ +    +++  P V++LD+ ++ +D   Q Q+ Q + 
Sbjct: 689  PQG--YDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLY 746

Query: 1422 ATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFG 1470
             +     R  LL T +++  E   D +  +  G +R  G+ Q L  K G
Sbjct: 747  ESPERYSRSVLLITQHLSLVEQ-ADHILFLEGGAIREGGTHQQLMEKKG 794



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 65/258 (25%), Positives = 108/258 (41%), Gaps = 52/258 (20%)

Query: 457 MDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILG 516
           +D  P    S    P   +G   ++ ++V+  Y  +PD +  L+ L F +  G++TA++G
Sbjct: 542 LDRTPRCPPSGLLTPLHLEG--LVQFQDVSFAYPNRPDVL-VLQGLTFTLRPGEVTALVG 598

Query: 517 HSGAGKSTLLNILSGLSVPTKGSVTIYNNKL---------SEMADLENLSKLTGVCPQSN 567
            +G+GKST+  +L  L  PT G + +    L          ++A +    ++ G   Q N
Sbjct: 599 PNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQEN 658

Query: 568 VQFDFL---TVRENLRLFAK------IKGILPQEVDKE---------------------- 596
           + +      T+ E      K      I G LPQ  D E                      
Sbjct: 659 IAYGLTQKPTMEEITAAAVKSGAHSFISG-LPQGYDTEVDEAGSQLSGGQRQAVALARAL 717

Query: 597 -----IFLLDEPTAGLDPFSRHQVWNLLKE--RKTDRVILFSTQFMDEADILADRKVFLS 649
                + +LD+ T+ LD  S+ QV  LL E   +  R +L  TQ +   +  AD  +FL 
Sbjct: 718 IRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVE-QADHILFLE 776

Query: 650 QGKLKCAGSSLFLKKKWG 667
            G ++  G+   L +K G
Sbjct: 777 GGAIREGGTHQQLMEKKG 794


>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sapiens]
          Length = 651

 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 59/214 (27%), Positives = 103/214 (48%), Gaps = 26/214 (12%)

Query: 1267 RNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDAL------EF 1320
            ++VS  V  G+++ +LG +G+GK+T +  ++G     AG  L +    G AL      + 
Sbjct: 70   KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLG-RAGTFLGEVYVNGRALRREQFQDC 128

Query: 1321 LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGD------------AEVAITRLVDALKLQ 1368
              Y  Q + L  +LTVR+ L  Y A+  +R+G+            AE++++ + D L   
Sbjct: 129  FSYVLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGN 187

Query: 1369 DQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTE 1428
              L      +S G +R++     +L +P V+L DEP+TG+D     Q+   +        
Sbjct: 188  YSLGG----ISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRN 242

Query: 1429 RGALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGS 1461
            R  +LT H   +E   + D++AI+  G L   G+
Sbjct: 243  RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 57/214 (26%), Positives = 82/214 (38%), Gaps = 56/214 (26%)

Query: 497 EALKDLVFDIYEGQITAILGHSGAGKSTLLNILS---GLSVPTKGSVTIYNNKLSEMADL 553
           + LKD+   +  GQI  ILG SG+GK+TLL+ +S   G +    G V +    L      
Sbjct: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---- 122

Query: 554 ENLSKLTGVCPQSNVQFDFLTVRENLRLFA--------------KIKGILPQ-------- 591
           E          QS+     LTVRE L   A              K++ ++ +        
Sbjct: 123 EQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVAD 182

Query: 592 -------------------------EVDKEIFLLDEPTAGLDPFSRHQVWNLLKE--RKT 624
                                      D ++ L DEPT GLD  + +Q+  LL E  R+ 
Sbjct: 183 RLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRN 242

Query: 625 DRVILFSTQFMDEADILADRKVFLSQGKLKCAGS 658
             V+L   Q   E   L D+   LS G+L   G+
Sbjct: 243 RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276


>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
            sapiens]
          Length = 1480

 Score = 64.7 bits (156), Expect = 7e-10
 Identities = 54/207 (26%), Positives = 96/207 (46%), Gaps = 14/207 (6%)

Query: 1268 NVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDAL-----EFLG 1322
            N+SF +  G+ +GLLG  G+GKST +         T G++ + G            +  G
Sbjct: 1229 NISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFG 1287

Query: 1323 YCPQENALWPNLTVRQHLEVYA--AVKGLRKGDAEVAITRLVDAL--KLQDQLKSPVKTL 1378
              PQ+  ++   T R++L+ Y   + + + K   EV +  +++    KL   L      L
Sbjct: 1288 VIPQKVFIFSG-TFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVL 1346

Query: 1379 SEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYM 1438
            S G K+ +C   S+L    ++LLDEPS  +DP   Q + + ++  F +     ++   + 
Sbjct: 1347 SHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADC---TVILCEHR 1403

Query: 1439 AEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
             EA   C +  ++   ++R   SIQ L
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKL 1430



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 40/205 (19%), Positives = 93/205 (45%), Gaps = 15/205 (7%)

Query: 1267 RNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEFLGYCPQ 1326
            ++++F + +G++L + G  GAGK++ + VI G+ +P+ G++   G         + +C Q
Sbjct: 442  KDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR--------ISFCSQ 493

Query: 1327 ENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQ----LKSPVKTLSEGI 1382
             + + P  T+++++    +    R      A     D  K  ++    L     TLS G 
Sbjct: 494  FSWIMPG-TIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQ 552

Query: 1383 KRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAE 1442
            + ++    ++  +  + LLD P   +D   +++++++        +   L+T+    E  
Sbjct: 553  RARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS--KMEHL 610

Query: 1443 AVCDRVAIMVSGRLRCIGSIQHLKS 1467
               D++ I+  G     G+   L++
Sbjct: 611  KKADKILILHEGSSYFYGTFSELQN 635



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 69/307 (22%), Positives = 125/307 (40%), Gaps = 53/307 (17%)

Query: 482  IRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVT 541
            ++++T +Y    + I  L+++ F I  GQ   +LG +G+GKSTLL+    L + T+G + 
Sbjct: 1212 VKDLTAKYTEGGNAI--LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL-LNTEGEIQ 1268

Query: 542  IYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIFLLD 601
            I                         V +D +T+++    + K  G++PQ+V        
Sbjct: 1269 I-----------------------DGVSWDSITLQQ----WRKAFGVIPQKV---FIFSG 1298

Query: 602  EPTAGLDPF---SRHQVWNLLKERKTDRVILFSTQFMDEAD-ILADRKVFLSQG--KLKC 655
                 LDP+   S  ++W +  E     VI    QF  + D +L D    LS G  +L C
Sbjct: 1299 TFRKNLDPYEQWSDQEIWKVADEVGLRSVI---EQFPGKLDFVLVDGGCVLSHGHKQLMC 1355

Query: 656  AGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDA-------KLSAKSEGKLIY 708
               S+  K K  +    S  L+ +   + I   +KQ   D        ++ A  E +   
Sbjct: 1356 LARSVLSKAKILLLDEPSAHLDPV-TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414

Query: 709  TLPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQ 768
             +   +  ++  + K L+   +  +    +S +   ++F         ++  IA L E  
Sbjct: 1415 VIEENKVRQYDSIQKLLN---ERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEET 1471

Query: 769  AEKADDT 775
             E+  DT
Sbjct: 1472 EEEVQDT 1478



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 18/42 (42%), Positives = 29/42 (69%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSV 540
           LKD+ F I  GQ+ A+ G +GAGK++LL ++ G   P++G +
Sbjct: 441 LKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI 482


>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
            [Homo sapiens]
          Length = 663

 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 53/212 (25%), Positives = 104/212 (49%), Gaps = 6/212 (2%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAGQVLLKGSGGGDA 1317
            K+  K   + +S     GE++ ++G +GAGKST + ++ G  +    G VL+ G      
Sbjct: 91   KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 150

Query: 1318 L--EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITR-LVDALKLQDQLKSP 1374
               +   Y  Q++ L P+LTV++ + V A +K   K +    + + ++ AL L     + 
Sbjct: 151  CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 210

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
              +LS G +++L   L ++ NP V+  DEP++G+D     Q+   ++   +   R  + T
Sbjct: 211  TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 269

Query: 1435 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
             H   A+   + D++ ++  G+    G + +L
Sbjct: 270  IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 301



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 48/198 (24%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGL-SVPTKGSVTIYNNKLSEMADLENLS 557
           LK +      G++ AI+G SGAGKSTL+NIL+G      KG+V I  N L    DL    
Sbjct: 98  LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI--NGLPR--DLRCFR 153

Query: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE--------------------- 596
           K++    Q ++    LTV+E + + A +K     E  +E                     
Sbjct: 154 KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 213

Query: 597 --------------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMD 636
                               +   DEPT+GLD  S  QV +L+K        +  T    
Sbjct: 214 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 273

Query: 637 EADI--LADRKVFLSQGK 652
            A +  L D+   LSQG+
Sbjct: 274 SAKLFELFDQLYVLSQGQ 291


>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
            [Homo sapiens]
          Length = 644

 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 53/212 (25%), Positives = 104/212 (49%), Gaps = 6/212 (2%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAGQVLLKGSGGGDA 1317
            K+  K   + +S     GE++ ++G +GAGKST + ++ G  +    G VL+ G      
Sbjct: 72   KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 131

Query: 1318 L--EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITR-LVDALKLQDQLKSP 1374
               +   Y  Q++ L P+LTV++ + V A +K   K +    + + ++ AL L     + 
Sbjct: 132  CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 191

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
              +LS G +++L   L ++ NP V+  DEP++G+D     Q+   ++   +   R  + T
Sbjct: 192  TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 250

Query: 1435 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
             H   A+   + D++ ++  G+    G + +L
Sbjct: 251  IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 282



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 48/198 (24%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGL-SVPTKGSVTIYNNKLSEMADLENLS 557
           LK +      G++ AI+G SGAGKSTL+NIL+G      KG+V I  N L    DL    
Sbjct: 79  LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI--NGLPR--DLRCFR 134

Query: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE--------------------- 596
           K++    Q ++    LTV+E + + A +K     E  +E                     
Sbjct: 135 KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 194

Query: 597 --------------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMD 636
                               +   DEPT+GLD  S  QV +L+K        +  T    
Sbjct: 195 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 254

Query: 637 EADI--LADRKVFLSQGK 652
            A +  L D+   LSQG+
Sbjct: 255 SAKLFELFDQLYVLSQGQ 272


>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
            [Homo sapiens]
          Length = 668

 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 53/212 (25%), Positives = 104/212 (49%), Gaps = 6/212 (2%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAGQVLLKGSGGGDA 1317
            K+  K   + +S     GE++ ++G +GAGKST + ++ G  +    G VL+ G      
Sbjct: 96   KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 155

Query: 1318 L--EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITR-LVDALKLQDQLKSP 1374
               +   Y  Q++ L P+LTV++ + V A +K   K +    + + ++ AL L     + 
Sbjct: 156  CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 215

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
              +LS G +++L   L ++ NP V+  DEP++G+D     Q+   ++   +   R  + T
Sbjct: 216  TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 274

Query: 1435 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
             H   A+   + D++ ++  G+    G + +L
Sbjct: 275  IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 306



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 48/198 (24%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGL-SVPTKGSVTIYNNKLSEMADLENLS 557
           LK +      G++ AI+G SGAGKSTL+NIL+G      KG+V I  N L    DL    
Sbjct: 103 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI--NGLPR--DLRCFR 158

Query: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE--------------------- 596
           K++    Q ++    LTV+E + + A +K     E  +E                     
Sbjct: 159 KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 218

Query: 597 --------------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMD 636
                               +   DEPT+GLD  S  QV +L+K        +  T    
Sbjct: 219 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 278

Query: 637 EADI--LADRKVFLSQGK 652
            A +  L D+   LSQG+
Sbjct: 279 SAKLFELFDQLYVLSQGQ 296


>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
            [Homo sapiens]
          Length = 677

 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 53/212 (25%), Positives = 104/212 (49%), Gaps = 6/212 (2%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAGQVLLKGSGGGDA 1317
            K+  K   + +S     GE++ ++G +GAGKST + ++ G  +    G VL+ G      
Sbjct: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 164

Query: 1318 L--EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITR-LVDALKLQDQLKSP 1374
               +   Y  Q++ L P+LTV++ + V A +K   K +    + + ++ AL L     + 
Sbjct: 165  CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 224

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
              +LS G +++L   L ++ NP V+  DEP++G+D     Q+   ++   +   R  + T
Sbjct: 225  TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 283

Query: 1435 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
             H   A+   + D++ ++  G+    G + +L
Sbjct: 284  IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 315



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 48/198 (24%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGL-SVPTKGSVTIYNNKLSEMADLENLS 557
           LK +      G++ AI+G SGAGKSTL+NIL+G      KG+V I  N L    DL    
Sbjct: 112 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI--NGLPR--DLRCFR 167

Query: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE--------------------- 596
           K++    Q ++    LTV+E + + A +K     E  +E                     
Sbjct: 168 KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 227

Query: 597 --------------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMD 636
                               +   DEPT+GLD  S  QV +L+K        +  T    
Sbjct: 228 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 287

Query: 637 EADI--LADRKVFLSQGK 652
            A +  L D+   LSQG+
Sbjct: 288 SAKLFELFDQLYVLSQGQ 305


>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
            [Homo sapiens]
          Length = 678

 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 53/212 (25%), Positives = 104/212 (49%), Gaps = 6/212 (2%)

Query: 1259 KRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKP-TAGQVLLKGSGGGDA 1317
            K+  K   + +S     GE++ ++G +GAGKST + ++ G  +    G VL+ G      
Sbjct: 94   KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 153

Query: 1318 L--EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITR-LVDALKLQDQLKSP 1374
               +   Y  Q++ L P+LTV++ + V A +K   K +    + + ++ AL L     + 
Sbjct: 154  CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 213

Query: 1375 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLT 1434
              +LS G +++L   L ++ NP V+  DEP++G+D     Q+   ++   +   R  + T
Sbjct: 214  TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 272

Query: 1435 THY-MAEAEAVCDRVAIMVSGRLRCIGSIQHL 1465
             H   A+   + D++ ++  G+    G + +L
Sbjct: 273  IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 304



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 48/198 (24%)

Query: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGL-SVPTKGSVTIYNNKLSEMADLENLS 557
           LK +      G++ AI+G SGAGKSTL+NIL+G      KG+V I  N L    DL    
Sbjct: 101 LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI--NGLPR--DLRCFR 156

Query: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKE--------------------- 596
           K++    Q ++    LTV+E + + A +K     E  +E                     
Sbjct: 157 KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 216

Query: 597 --------------------IFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMD 636
                               +   DEPT+GLD  S  QV +L+K        +  T    
Sbjct: 217 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 276

Query: 637 EADI--LADRKVFLSQGK 652
            A +  L D+   LSQG+
Sbjct: 277 SAKLFELFDQLYVLSQGQ 294


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,206,333
Number of Sequences: 37866
Number of extensions: 2436131
Number of successful extensions: 7081
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 6451
Number of HSP's gapped (non-prelim): 374
length of query: 1581
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1465
effective length of database: 13,855,062
effective search space: 20297665830
effective search space used: 20297665830
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.