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Search of human proteins with 59889560
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59889560 neurotrophic tyrosine kinase, receptor, type 3
isoform b precursor [Homo sapiens]
(825 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 1701 0.0
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 1692 0.0
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo... 1096 0.0
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 868 0.0
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 858 0.0
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 747 0.0
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 746 0.0
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 741 0.0
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo... 363 e-100
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo... 352 6e-97
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo... 280 5e-75
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 274 2e-73
gi|62420886 discoidin domain receptor family, member 2 precursor... 248 2e-65
gi|62420884 discoidin domain receptor family, member 2 precursor... 248 2e-65
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 247 4e-65
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 246 8e-65
gi|38327632 discoidin domain receptor family, member 1 isoform b... 241 3e-63
gi|83977450 discoidin domain receptor family, member 1 isoform a... 241 3e-63
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 238 2e-62
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 238 2e-62
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 237 4e-62
gi|83977452 discoidin domain receptor family, member 1 isoform c... 235 1e-61
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 233 5e-61
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 228 2e-59
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 226 5e-59
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 226 9e-59
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 223 6e-58
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 223 7e-58
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 222 1e-57
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 222 1e-57
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 1701 bits (4406), Expect = 0.0
Identities = 825/825 (100%), Positives = 825/825 (100%)
Query: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
Query: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540
Query: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
Sbjct: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600
Query: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
Sbjct: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
Query: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 720
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI
Sbjct: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 720
Query: 721 RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRV 780
RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRV
Sbjct: 721 RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRV 780
Query: 781 CPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 825
CPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Sbjct: 781 CPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 825
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 1692 bits (4381), Expect = 0.0
Identities = 825/839 (98%), Positives = 825/839 (98%), Gaps = 14/839 (1%)
Query: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
Query: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL 540
Query: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
Sbjct: 541 KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI 600
Query: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
Sbjct: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
Query: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR--------- 711
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYR
Sbjct: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF 720
Query: 712 -----VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 766
VGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
Sbjct: 721 CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 780
Query: 767 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 825
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Sbjct: 781 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
c precursor [Homo sapiens]
Length = 612
Score = 1096 bits (2834), Expect = 0.0
Identities = 529/530 (99%), Positives = 530/530 (100%)
Query: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
Sbjct: 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ 60
Query: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
Sbjct: 61 DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP 120
Query: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
Sbjct: 121 RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA 180
Query: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
Sbjct: 181 KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD 240
Query: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
Sbjct: 241 VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT 300
Query: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
Sbjct: 301 VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE 360
Query: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
Sbjct: 361 GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT 420
Query: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
Sbjct: 421 VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP 480
Query: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYV 530
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDT+V
Sbjct: 481 LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTWV 530
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 868 bits (2243), Expect = 0.0
Identities = 464/849 (54%), Positives = 573/849 (67%), Gaps = 66/849 (7%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
Query: 517 FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576
F ++ KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL P +DK+LVAVK LKD
Sbjct: 517 FGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD 576
Query: 577 PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
+ ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYMKHGDLNKFLRAHGPDA
Sbjct: 577 ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
Query: 637 MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696
+++ +G P EL SQMLHIA QIA+GMVYLASQHFVHRDLATRNCLVG NLLVKIG
Sbjct: 637 VLMAEGNPPT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIG 693
Query: 697 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWS GV+LWEIFTYGKQP
Sbjct: 694 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP 753
Query: 757 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKA 816
W+QLSN EVIECITQGRVL+RPR CP+EVY++MLGCWQREP R NIK I+ +L L KA
Sbjct: 754 WYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKA 813
Query: 817 TPIYLDILG 825
+P+YLDILG
Sbjct: 814 SPVYLDILG 822
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 858 bits (2216), Expect = 0.0
Identities = 464/865 (53%), Positives = 573/865 (66%), Gaps = 82/865 (9%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500
R SKFGMK GP +VIS ++DSASPLHHI++G TPSS + GPD
Sbjct: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
Query: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNL 560
V+IGMT+IPVIENPQYF ++ KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL
Sbjct: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL 576
Query: 561 SPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYM 620
P +DK+LVAVK LKD + ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYM
Sbjct: 577 CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 636
Query: 621 KHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680
KHGDLNKFLRAHGPDA+++ +G P EL SQMLHIA QIA+GMVYLASQHFVHRDL
Sbjct: 637 KHGDLNKFLRAHGPDAVLMAEGNPPT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDL 693
Query: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740
ATRNCLVG NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW
Sbjct: 694 ATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 753
Query: 741 SFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR 800
S GV+LWEIFTYGKQPW+QLSN EVIECITQGRVL+RPR CP+EVY++MLGCWQREP R
Sbjct: 754 SLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 813
Query: 801 LNIKEIYKILHALGKATPIYLDILG 825
NIK I+ +L L KA+P+YLDILG
Sbjct: 814 KNIKGIHTLLQNLAKASPVYLDILG 838
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 747 bits (1928), Expect = 0.0
Identities = 399/752 (53%), Positives = 503/752 (66%), Gaps = 29/752 (3%)
Query: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
Query: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
Query: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
Query: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
Query: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
Query: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVS 433
GNYTL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS
Sbjct: 357 GNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVS 413
Query: 434 IAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSS 493
+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S
Sbjct: 414 VAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSP 472
Query: 494 LDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVF 553
+ G + + G +IENPQYF D V HIKRRDIVLK ELGEGAFGKVF
Sbjct: 473 TE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVF 519
Query: 554 LAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPL 613
LAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL
Sbjct: 520 LAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPL 579
Query: 614 IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ 673
+MVFEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +ASQ+A+GMVYLA
Sbjct: 580 LMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGL 638
Query: 674 HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKF 733
HFVHRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYRVGG TMLPIRWMPPESI+YRKF
Sbjct: 639 HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKF 698
Query: 734 TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 793
TTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR CP EVY +M GCW
Sbjct: 699 TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW 758
Query: 794 QREPQQRLNIKEIYKILHALGKATPIYLDILG 825
QREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 759 QREPQQRHSIKDVHARLQALAQAPPVYLDVLG 790
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 746 bits (1925), Expect = 0.0
Identities = 402/766 (52%), Positives = 503/766 (65%), Gaps = 51/766 (6%)
Query: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
Query: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
Query: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
Query: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
Query: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
Query: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKP-------- 425
GNYTL+A NP G A+ +I F+ PF E +P PI V+ P
Sbjct: 357 GNYTLLAANPFGQASASIMAAFMDNPF-----------EFNPEDPIPVSFSPVDTNSTSG 405
Query: 426 ------EEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSAS 479
+E FGVS+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A
Sbjct: 406 DPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAM 464
Query: 480 PLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIV 539
LH + G ++ S + G + + G +IENPQYF D V HIKRRDIV
Sbjct: 465 SLHFMTLGGSSLSPTE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIV 511
Query: 540 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 599
LK ELGEGAFGKVFLAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+H
Sbjct: 512 LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH 571
Query: 600 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 659
IV+F+GVC +G PL+MVFEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +
Sbjct: 572 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAV 630
Query: 660 ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 719
ASQ+A+GMVYLA HFVHRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYRVGG TMLP
Sbjct: 631 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 690
Query: 720 IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR 779
IRWMPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR
Sbjct: 691 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 750
Query: 780 VCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 825
CP EVY +M GCWQREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 751 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 796
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 741 bits (1913), Expect = 0.0
Identities = 397/749 (53%), Positives = 500/749 (66%), Gaps = 29/749 (3%)
Query: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
+ + +IEN + L L D+ L+ LTI SGLR + P AF P L +NLS N L
Sbjct: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
Query: 140 TTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPL 199
+LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q PL
Sbjct: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQGPL 153
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
M + C +P + V N +V GD+ ++ C G L WI+T L+ T +
Sbjct: 154 AHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SATVMK 210
Query: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH 319
+ ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 211 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH-HW 269
Query: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNNGNY 376
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NNGNY
Sbjct: 270 CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNY 329
Query: 377 TLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
TL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS+AV
Sbjct: 330 TLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVSVAV 386
Query: 437 GLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDA 496
GLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S +
Sbjct: 387 GLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSPTE- 444
Query: 497 GPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAE 556
G + + G +IENPQYF D V HIKRRDIVLK ELGEGAFGKVFLAE
Sbjct: 445 GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVFLAE 492
Query: 557 CYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMV 616
C+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL+MV
Sbjct: 493 CHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMV 552
Query: 617 FEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFV 676
FEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +ASQ+A+GMVYLA HFV
Sbjct: 553 FEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 611
Query: 677 HRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE 736
HRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYRVGG TMLPIRWMPPESI+YRKFTTE
Sbjct: 612 HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTE 671
Query: 737 SDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQRE 796
SDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR CP EVY +M GCWQRE
Sbjct: 672 SDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQRE 731
Query: 797 PQQRLNIKEIYKILHALGKATPIYLDILG 825
PQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 732 PQQRHSIKDVHARLQALAQAPPVYLDVLG 760
>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
e precursor [Homo sapiens]
Length = 537
Score = 363 bits (931), Expect = e-100
Identities = 219/553 (39%), Positives = 308/553 (55%), Gaps = 63/553 (11%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411
GCL + PTH NNG+YTLIAKN G + I+ HF+ P + N ++++
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456
+ P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
R SKFGMKGP +VIS ++DSASPLHHI++G TPSS + GPD V+IGMT+IPVIENPQY
Sbjct: 457 ARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQY 516
Query: 517 FRQGHNCHKPDTY 529
F ++ KPDT+
Sbjct: 517 FGITNSQLKPDTW 529
>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
d precursor [Homo sapiens]
Length = 553
Score = 352 bits (904), Expect = 6e-97
Identities = 220/569 (38%), Positives = 308/569 (54%), Gaps = 79/569 (13%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402
GCL + PTH NNG+YTLIAKN G + I+ HF+ P +P+
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456
+ D + + P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500
R SKFGMK GP +VIS ++DSASPLHHI++G TPSS + GPD
Sbjct: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
Query: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTY 529
V+IGMT+IPVIENPQYF ++ KPDT+
Sbjct: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTW 545
>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
b precursor [Homo sapiens]
Length = 477
Score = 280 bits (715), Expect = 5e-75
Identities = 180/490 (36%), Positives = 257/490 (52%), Gaps = 63/490 (12%)
Query: 7 PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63
PA W G WL + + ACP +C CS + I C P G + FP LE
Sbjct: 10 PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
Query: 64 NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123
N D NIT I I N + L +N D+E Y GL+ LTI +SGL+ + +AF
Sbjct: 61 --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
Query: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183
KN +L++IN + N+LT+LS + F+ L L EL L N F CSCDI W++ QE ++ +
Sbjct: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
Query: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243
+Q+LYC+N +PL + I C LP +++ NLTV EG + ++C+ +G P+P++ W
Sbjct: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
Query: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303
V L S ++N T+ +L + N++S+D+G ++C+AEN+VG SV LTV++
Sbjct: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355
P + LE P CI F V+GNP P L W +NG L ESK I H EY+
Sbjct: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
Query: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402
GCL + PTH NNG+YTLIAKN G + I+ HF+ P +P+
Sbjct: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
Query: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456
+ D + + P VT K + V V +A+ LLV+LF++ K
Sbjct: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
Query: 457 GRRSKFGMKG 466
R SKFGMKG
Sbjct: 457 ARHSKFGMKG 466
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 274 bits (701), Expect = 2e-73
Identities = 133/288 (46%), Positives = 189/288 (65%), Gaps = 9/288 (3%)
Query: 535 RRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLA-ARKDFQREAELLT 593
R +I R++GEGAFG+VF A L P + +VAVK LK+ A + DFQREA L+
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
Query: 594 NLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGE--- 650
+ +IVK GVC G P+ ++FEYM +GDLN+FLR+ P + + + +
Sbjct: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
Query: 651 -----LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 705
L ++ L IA Q+A+GM YL+ + FVHRDLATRNCLVG N++VKI DFG+SR++Y
Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
Query: 706 STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV 765
S DYY+ + +PIRWMPPESI Y ++TTESDVW++GV+LWEIF+YG QP++ +++ EV
Sbjct: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
Query: 766 IECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 813
I + G +L P CP E+Y++M CW + P R + I++IL +
Sbjct: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERM 859
Score = 53.5 bits (127), Expect = 8e-07
Identities = 55/186 (29%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 210 PEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLT 269
P+I+ +N+ + EG AV+ C G+P P V WI + + + N + + +L
Sbjct: 121 PKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWI----KGDSPLRENSRIAVLESGSLR 176
Query: 270 LVNVTSEDNGFTLTCIAENVVGMSNASVA-LTVYYPPRVVSLEEPELRLEHCIEF----- 323
+ NV ED G C+A+N +G + + V L V R+ L PE H + F
Sbjct: 177 IHNVQKEDAG-QYRCVAKNSLGTAYSKVVKLEVEVFARI--LRAPE---SHNVTFGSFVT 230
Query: 324 ---VVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLF-NKPTHYNNGNYTLI 379
G P PT+ W+ NG + I E ++ I LF KP G YT I
Sbjct: 231 LHCTATGIPVPTITWIENGNAVSSGSI--QESVKDRVIDSRLQLFITKP-----GLYTCI 283
Query: 380 AKNPLG 385
A N G
Sbjct: 284 ATNKHG 289
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/168 (27%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 227 AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286
A C P P++ W + I T + + LT+++V D+G C A
Sbjct: 45 ATFMCAVESYPQPEISWTRNKIL-IKLFDTRYSIRENGQL-LTILSVEDSDDGI-YCCTA 101
Query: 287 ENVVGMSNASV-ALTVYYPPRVVSLEEPELR------LEHCIEFVVRGNPPPTLHWLHNG 339
N VG + S AL V P++ P + L+ + GNP P++ W+
Sbjct: 102 NNGVGGAVESCGALQVKMKPKIT---RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGD 158
Query: 340 QPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
PLRE+ I V + G L + + G Y +AKN LGTA
Sbjct: 159 SPLRENSRIAV-------LESGSLRIHNVQKEDAGQYRCVAKNSLGTA 199
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 248 bits (633), Expect = 2e-65
Identities = 139/304 (45%), Positives = 189/304 (62%), Gaps = 26/304 (8%)
Query: 527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK-----------MLVAVKALK 575
D V+ R+ + K +LGEG FG+V L E + KDK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 576 -DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634
D AR DF +E ++++ L+ +I+ VC DPL M+ EYM++GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 635 DAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVK 694
D + + + + +A+QIASGM YL+S +FVHRDLATRNCLVG N +K
Sbjct: 672 PNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725
Query: 695 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY-G 753
I DFGMSR++YS DYYR+ G +LPIRWM ESI+ KFTT SDVW+FGV LWE FT+
Sbjct: 726 IADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQ 785
Query: 754 KQPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
+QP+ QLS+ +VIE QGR L +P +CP VY +ML CW+R+ + R + +EI
Sbjct: 786 EQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 845
Query: 807 YKIL 810
+ +L
Sbjct: 846 HLLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 248 bits (633), Expect = 2e-65
Identities = 139/304 (45%), Positives = 189/304 (62%), Gaps = 26/304 (8%)
Query: 527 DTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK-----------MLVAVKALK 575
D V+ R+ + K +LGEG FG+V L E + KDK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 576 -DPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP 634
D AR DF +E ++++ L+ +I+ VC DPL M+ EYM++GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 635 DAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVK 694
D + + + + +A+QIASGM YL+S +FVHRDLATRNCLVG N +K
Sbjct: 672 PNSSSSDVRT------VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIK 725
Query: 695 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY-G 753
I DFGMSR++YS DYYR+ G +LPIRWM ESI+ KFTT SDVW+FGV LWE FT+
Sbjct: 726 IADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQ 785
Query: 754 KQPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
+QP+ QLS+ +VIE QGR L +P +CP VY +ML CW+R+ + R + +EI
Sbjct: 786 EQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 845
Query: 807 YKIL 810
+ +L
Sbjct: 846 HLLL 849
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 247 bits (630), Expect = 4e-65
Identities = 130/307 (42%), Positives = 182/307 (59%), Gaps = 9/307 (2%)
Query: 509 PVIENPQYFRQGH------NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSP 562
PV P++ R + N +KP + + + + ELGE AFGK++ Y L
Sbjct: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-LPG 496
Query: 563 TKDKMLVAVKALKDPTLAAR-KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMK 621
LVA+K LKD + +FQ+EA L+ L H +IV G P+ M+FEY+
Sbjct: 497 MDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYIN 556
Query: 622 HGDLNKFLRAHGPDAMI-LVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680
GDL++FL P + + + K L LHIA QIA+GM YL+S FVH+DL
Sbjct: 557 QGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDL 616
Query: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740
A RN L+G L VKI D G+SR++YS DYYRV ++LPIRWMPPE+IMY KF+++SD+W
Sbjct: 617 AARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIW 676
Query: 741 SFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR 800
SFGV+LWEIF++G QP++ SN EVIE + + ++L CP +Y +M CW P +R
Sbjct: 677 SFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRR 736
Query: 801 LNIKEIY 807
K+I+
Sbjct: 737 PRFKDIH 743
Score = 34.3 bits (77), Expect = 0.48
Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
N+T G A + C SG+P P + W + + + ++ L + N+ + D
Sbjct: 66 NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305
G+ C+A N + +++ L V + P
Sbjct: 126 TGY-FQCVATNGKEVVSSTGVLFVKFGP 152
Score = 31.2 bits (69), Expect = 4.1
Identities = 17/55 (30%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 288 NVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPL 342
N+ N LT+ P ++ + HC V GNPPPT+ W N P+
Sbjct: 47 NISSELNKDSYLTLDEPMNNITTSLGQTAELHC---KVSGNPPPTIRWFKNDAPV 98
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 246 bits (627), Expect = 8e-65
Identities = 127/294 (43%), Positives = 176/294 (59%), Gaps = 2/294 (0%)
Query: 522 NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA 581
N HK ++ I + ELGE FGKV+ + +P + VA+K LKD
Sbjct: 458 NQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP 516
Query: 582 -RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV 640
R++F+ EA L LQH ++V GV PL M+F Y HGDL++FL P + +
Sbjct: 517 LREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGS 576
Query: 641 DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGM 700
R K L +H+ +QIA+GM YL+S H VH+DLATRN LV L VKI D G+
Sbjct: 577 TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636
Query: 701 SRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQL 760
R+VY+ DYY++ G+++LPIRWM PE+IMY KF+ +SD+WS+GV+LWE+F+YG QP+
Sbjct: 637 FREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGY 696
Query: 761 SNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALG 814
SN +V+E I +VL P CP VY +M+ CW P +R K+I+ L A G
Sbjct: 697 SNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWG 750
Score = 35.8 bits (81), Expect = 0.17
Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 1/88 (1%)
Query: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
N+T+ +G A++ C +G+P P+V W+ + + + + L + ++ + D
Sbjct: 70 NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129
Query: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305
G+ C+A N + A+ L V P
Sbjct: 130 TGY-YQCVATNGMKTITATGVLFVRLGP 156
Score = 31.6 bits (70), Expect = 3.1
Identities = 23/88 (26%), Positives = 38/88 (43%), Gaps = 8/88 (9%)
Query: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQP-LRESKIIHVEYYQEGEISEGC 362
P +++ + + + HC V GNPPP + WL N P ++E + I + + G
Sbjct: 67 PVNNITIVQGQTAILHC---KVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYG----SR 119
Query: 363 LLFNKPTHYNNGNYTLIAKNPLGTANQT 390
L + G Y +A N + T T
Sbjct: 120 LRIQDLDTTDTGYYQCVATNGMKTITAT 147
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 241 bits (614), Expect = 3e-63
Identities = 138/300 (46%), Positives = 188/300 (62%), Gaps = 25/300 (8%)
Query: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALK-DPTLAAR 582
R + K +LGEG FG+V L E + L+ K +LVAVK L+ D T AR
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
Query: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV-- 640
DF +E ++++ L+ +I++ GVC DPL M+ +YM++GDLN+FL AH +
Sbjct: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
Query: 641 --DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 698
DGQ Q + +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N +KI DF
Sbjct: 690 PGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 748
Query: 699 GMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPW 757
GMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+FGV LWE+ + QP+
Sbjct: 749 GMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 808
Query: 758 FQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
QL++ +VIE QGR L RP CP+ +Y++ML CW RE +QR ++++ L
Sbjct: 809 GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 868
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 241 bits (614), Expect = 3e-63
Identities = 138/300 (46%), Positives = 188/300 (62%), Gaps = 25/300 (8%)
Query: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALK-DPTLAAR 582
R + K +LGEG FG+V L E + L+ K +LVAVK L+ D T AR
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 666
Query: 583 KDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV-- 640
DF +E ++++ L+ +I++ GVC DPL M+ +YM++GDLN+FL AH +
Sbjct: 667 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 726
Query: 641 --DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDF 698
DGQ Q + +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N +KI DF
Sbjct: 727 PGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 785
Query: 699 GMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGK-QPW 757
GMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+FGV LWE+ + QP+
Sbjct: 786 GMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 845
Query: 758 FQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
QL++ +VIE QGR L RP CP+ +Y++ML CW RE +QR ++++ L
Sbjct: 846 GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL 905
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 238 bits (607), Expect = 2e-62
Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 13/303 (4%)
Query: 513 NPQYFRQGH----NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 568
NP+Y + + PD + + R I L RELG+G+FG V+ ++ + +
Sbjct: 984 NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041
Query: 569 VAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
VAVK + + +L R +F EA ++ H+V+ GV G P ++V E M HGDL
Sbjct: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101
Query: 628 FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
+LR+ P+A + + L +M+ +A++IA GM YL ++ FVHRDLA RNC+V
Sbjct: 1102 YLRSLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 1155
Query: 688 GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW 747
+ VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SD+WSFGV+LW
Sbjct: 1156 AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLW 1215
Query: 748 EIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIY 807
EI + +QP+ LSN +V++ + G L++P CP+ V D+M CWQ P+ R EI
Sbjct: 1216 EITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1275
Query: 808 KIL 810
+L
Sbjct: 1276 NLL 1278
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 238 bits (607), Expect = 2e-62
Identities = 124/303 (40%), Positives = 180/303 (59%), Gaps = 13/303 (4%)
Query: 513 NPQYFRQGH----NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKML 568
NP+Y + + PD + + R I L RELG+G+FG V+ ++ + +
Sbjct: 996 NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1053
Query: 569 VAVKALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
VAVK + + +L R +F EA ++ H+V+ GV G P ++V E M HGDL
Sbjct: 1054 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1113
Query: 628 FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
+LR+ P+A + + L +M+ +A++IA GM YL ++ FVHRDLA RNC+V
Sbjct: 1114 YLRSLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV 1167
Query: 688 GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW 747
+ VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SD+WSFGV+LW
Sbjct: 1168 AHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLW 1227
Query: 748 EIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIY 807
EI + +QP+ LSN +V++ + G L++P CP+ V D+M CWQ P+ R EI
Sbjct: 1228 EITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIV 1287
Query: 808 KIL 810
+L
Sbjct: 1288 NLL 1290
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 237 bits (604), Expect = 4e-62
Identities = 121/295 (41%), Positives = 179/295 (60%), Gaps = 10/295 (3%)
Query: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
NP+YF + + PD + + R I + RELG+G+FG V+ + + + VA+K
Sbjct: 977 NPEYFSAA-DVYVPDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033
Query: 573 ALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRA 631
+ + ++ R +F EA ++ H+V+ GV G P +++ E M GDL +LR+
Sbjct: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093
Query: 632 HGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL 691
P+ ++ P A L S+M+ +A +IA GM YL + FVHRDLA RNC+V +
Sbjct: 1094 LRPE----MENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147
Query: 692 LVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 751
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SDVWSFGV+LWEI T
Sbjct: 1148 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 1207
Query: 752 YGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
+QP+ LSN +V+ + +G +L++P CP ++++M CWQ P+ R + EI
Sbjct: 1208 LAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 235 bits (600), Expect = 1e-61
Identities = 136/306 (44%), Positives = 188/306 (61%), Gaps = 31/306 (10%)
Query: 535 RRDIVLKRELGEGAFGKVFLAEC----------YNLSPTKDK-MLVAVKALKDP------ 577
R + K +LGEG FG+V L E + L+ K +LVAVK L+
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAS 666
Query: 578 -TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
+L +R DF +E ++++ L+ +I++ GVC DPL M+ +YM++GDLN+FL AH +
Sbjct: 667 FSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 726
Query: 637 MILV----DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLL 692
DGQ Q + +LH+A+QIASGM YLA+ +FVHRDLATRNCLVG N
Sbjct: 727 KAAEGAPGDGQAAQGP-TISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 785
Query: 693 VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY 752
+KI DFGMSR++Y+ DYYRV G +LPIRWM E I+ KFTT SDVW+FGV LWE+
Sbjct: 786 IKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLML 845
Query: 753 GK-QPWFQLSNTEVIECI-----TQGR--VLERPRVCPKEVYDVMLGCWQREPQQRLNIK 804
+ QP+ QL++ +VIE QGR L RP CP+ +Y++ML CW RE +QR
Sbjct: 846 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 905
Query: 805 EIYKIL 810
++++ L
Sbjct: 906 QLHRFL 911
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 233 bits (594), Expect = 5e-61
Identities = 127/297 (42%), Positives = 179/297 (60%), Gaps = 14/297 (4%)
Query: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
NP+YF + + PD + + R I + RELG+G+FG V+ L ++ VA+K
Sbjct: 957 NPEYF-SASDMYVPDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013
Query: 573 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
+ + LA+ ++ F +EA ++ + H+V+ GV G P +++ E M GDL L
Sbjct: 1014 TVNE--LASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHL 1071
Query: 630 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA 689
R+ P+A G P+ A GE M+ +A +IA GM YLA+ FVHRDLA RNC+V
Sbjct: 1072 RSLRPEAENN-PGLPQPALGE-----MIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ 1125
Query: 690 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEI 749
+ VKIGDFGM+RDVY TDYYR GG +LP+RWM PES+ FTT SDVWSFGV+LWEI
Sbjct: 1126 DFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEI 1185
Query: 750 FTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
T +QP+ LSN +V++ + G VLE CP ++ ++M CWQ P+ R + I
Sbjct: 1186 VTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHI 1242
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 228 bits (580), Expect = 2e-59
Identities = 149/514 (28%), Positives = 248/514 (48%), Gaps = 53/514 (10%)
Query: 327 GNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
GNP PT+ WL NG+ ++ I + S L+ + GNYT + +N G+
Sbjct: 183 GNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWS---LIMESVVPSDKGNYTCVVENEYGS 239
Query: 387 ANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLL 446
N T + D V+P +T P+ + +G+ AC+++
Sbjct: 240 INHTYH-----------------LDVVAPGREKEITASPDYLEIAI-YCIGVFLIACMVV 281
Query: 447 VVLFVMINKYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDA 496
V+ + ++ F + V ++ +S+S ++ + + L +
Sbjct: 282 TVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSS 341
Query: 497 GPDTVVI-GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLA 555
DT ++ G++ + E+P++ R + L + LGEG FG+V +A
Sbjct: 342 TADTPMLAGVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMA 386
Query: 556 ECYNLSPTKDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGD 611
E + K K + VAVK LKD T D E E++ + +H++I+ G C
Sbjct: 387 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 446
Query: 612 PLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA 671
PL ++ EY G+L ++LRA P M R + ++ ++ Q+A GM YLA
Sbjct: 447 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 506
Query: 672 SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYR 731
SQ +HRDLA RN LV N ++KI DFG++RD+ + DYY+ + LP++WM PE++ R
Sbjct: 507 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 566
Query: 732 KFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLG 791
+T +SDVWSFGV++WEIFT G P+ + E+ + + +G +++P C E+Y +M
Sbjct: 567 VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRD 626
Query: 792 CWQREPQQRLNIKEIYKILHALGKAT--PIYLDI 823
CW P QR K++ + L + T YLD+
Sbjct: 627 CWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL 660
Score = 35.8 bits (81), Expect = 0.17
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 1/76 (1%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C G+P+P + W+ G + H+ +L + +V D G TC+ EN
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 237
Query: 291 GMSNASVALTVYYPPR 306
G N + L V P R
Sbjct: 238 GSINHTYHLDVVAPGR 253
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 226 bits (577), Expect = 5e-59
Identities = 176/602 (29%), Positives = 279/602 (46%), Gaps = 67/602 (11%)
Query: 227 AVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIA 286
A + C+ +G P + W S+ W +A L VT +D G TCIA
Sbjct: 520 ATVPCSATGREKPTIKWERADGSSLP------EWVTDNAGTLHFARVTRDDAG-NYTCIA 572
Query: 287 EN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNG 339
N G A V LTV P ++ + L C +G+P P + W
Sbjct: 573 SNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPKPLIQWKGKD 629
Query: 340 QPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFL 396
+ L +K+ +H+ G L+ + ++G YT IA N + + +
Sbjct: 630 RILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 682
Query: 397 KEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKY 456
+P PE ++ SP P + T G+S+ AA A ++ V+ + K
Sbjct: 683 DKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAVLGLMFYCKK 728
Query: 457 GRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQY 516
++K K P GEE L+ PS+ + + + + P N ++
Sbjct: 729 RCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGSGPAATNKRH 783
Query: 517 FRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKD 576
H P + +Q I LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 784 -STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQS 834
Query: 577 PTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDA 636
+ DF+RE E+ L H ++V+ G+C + +P MV EY+ GDL +FLR
Sbjct: 835 KDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR------ 888
Query: 637 MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIG 696
I + L Q + + +Q+A GM +L++ FVH+DLA RNCLV A VK+
Sbjct: 889 -ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 947
Query: 697 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
G+S+DVY+++YY +P+RWM PE+I+ F+T+SDVW+FGV++WE+FT+G+ P
Sbjct: 948 ALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMP 1006
Query: 757 WFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGK 815
++ EV+ + G+ L +P CP ++Y +M CW P+ R + E I ALG
Sbjct: 1007 HGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALGD 1063
Query: 816 AT 817
+T
Sbjct: 1064 ST 1065
Score = 38.1 bits (87), Expect = 0.034
Identities = 44/170 (25%), Positives = 62/170 (36%), Gaps = 23/170 (13%)
Query: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
G +TC G P P V W G++ + TH + H L L N+ D G
Sbjct: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
Query: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
TC A N+ G V +TV P+ LEE + C+ + P PT+ W
Sbjct: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
Query: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
N + E V G L N Y+ Y ++ P G+
Sbjct: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
Score = 34.3 bits (77), Expect = 0.48
Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)
Query: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
N CI ++G Q + + ++ V TV +G A++ C G P P + W
Sbjct: 567 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 625
Query: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
G I T L +H +L + +V ED+G TCIA N + + L V
Sbjct: 626 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 681
Query: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
P E P G+PPP
Sbjct: 682 VDKPVPEESEGP-------------GSPPP 698
Score = 33.9 bits (76), Expect = 0.63
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
Query: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
L V A L+ N CI + G + A + + PRV +
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
Query: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
Query: 370 HYNNGNYTLIAKNPLGTANQTIN 392
+ G YT A N G Q +N
Sbjct: 383 ESDAGVYTCHAANLAGQRRQDVN 405
Score = 31.6 bits (70), Expect = 3.1
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
Query: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 226 bits (575), Expect = 9e-59
Identities = 181/611 (29%), Positives = 283/611 (46%), Gaps = 70/611 (11%)
Query: 221 VREGDNAVITC---NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277
+ E D V TC N +G DV+ V S+ W +A L VT +D
Sbjct: 381 IAESDAGVYTCHAANLAGQRRQDVNITVANGSSLP------EWVTDNAGTLHFARVTRDD 434
Query: 278 NGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEEPELRLEHCIEFVVRGNPP 330
G TCIA N G A V LTV P ++ + L C +G+P
Sbjct: 435 AG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC---EAQGDPK 490
Query: 331 PTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTA 387
P + W + L +K+ +H+ G L+ + ++G YT IA N
Sbjct: 491 PLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVAPEDSGRYTCIAGNSCNIK 543
Query: 388 NQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLV 447
+ + + +P PE ++ SP P + T G+S+ AA A ++ V
Sbjct: 544 HTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QTIGLSVG---AAVAYIIAV 589
Query: 448 VLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTR 507
+ + K ++K K P GEE L+ PS+ + + + +
Sbjct: 590 LGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGS 644
Query: 508 IPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKM 567
P N ++ H P + +Q I LG+ FG+VFLA+ L +
Sbjct: 645 GPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEFGEVFLAKAQGLEEGVAET 695
Query: 568 LVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNK 627
LV VK+L+ + DF+RE E+ L H ++V+ G+C + +P MV EY+ GDL +
Sbjct: 696 LVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQ 755
Query: 628 FLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV 687
FLR I + L Q + + +Q+A GM +L++ FVH+DLA RNCLV
Sbjct: 756 FLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLV 808
Query: 688 GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW 747
A VK+ G+S+DVY+++YY +P+RWM PE+I+ F+T+SDVW+FGV++W
Sbjct: 809 SAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMW 867
Query: 748 EIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
E+FT+G+ P ++ EV+ + G+ L +P CP ++Y +M CW P+ R + E
Sbjct: 868 EVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE- 926
Query: 807 YKILHALGKAT 817
I ALG +T
Sbjct: 927 --IASALGDST 935
Score = 34.3 bits (77), Expect = 0.48
Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)
Query: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
N CI ++G Q + + ++ V TV +G A++ C G P P + W
Sbjct: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 495
Query: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
G I T L +H +L + +V ED+G TCIA N + + L V
Sbjct: 496 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 551
Query: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
P E P G+PPP
Sbjct: 552 VDKPVPEESEGP-------------GSPPP 568
Score = 33.9 bits (76), Expect = 0.63
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
Query: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
L V A L+ N CI + G + A + + PRV +
Sbjct: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
Query: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
Query: 370 HYNNGNYTLIAKNPLGTANQTIN 392
+ G YT A N G Q +N
Sbjct: 383 ESDAGVYTCHAANLAGQRRQDVN 405
Score = 31.6 bits (70), Expect = 3.1
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
Query: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
Query: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 223 bits (568), Expect = 6e-58
Identities = 121/296 (40%), Positives = 169/296 (57%), Gaps = 19/296 (6%)
Query: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
NP Y G D ++ + R++I L R LG GAFG+V+ + + + VAVK
Sbjct: 1093 NPNYCFAGKTSSISD--LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVK 1150
Query: 573 ALKDPTLAARKD---FQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFL 629
L P + + +D F EA +++ H++IV+ GV P ++ E M GDL FL
Sbjct: 1151 TL--PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFL 1208
Query: 630 RAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV-- 687
R P +P Q L + +LH+A IA G YL HF+HRD+A RNCL+
Sbjct: 1209 RETRP--------RPSQPSS-LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTC 1259
Query: 688 -GANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 746
G + KIGDFGM+RD+Y YYR GG MLP++WMPPE+ M FT+++D WSFGV+L
Sbjct: 1260 PGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLL 1319
Query: 747 WEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLN 802
WEIF+ G P+ SN EV+E +T G ++ P+ CP VY +M CWQ +P+ R N
Sbjct: 1320 WEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN 1375
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 223 bits (567), Expect = 7e-58
Identities = 170/626 (27%), Positives = 285/626 (45%), Gaps = 64/626 (10%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C G+P+P + W+ G + H+ +L + +V D G TC+ EN
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 237
Query: 291 GMSNASVALTVYYPPRVVSLEEPELRLEHC------IEFV--VRGNPPPTLHWLH----N 338
G N + L V + + L +EFV V + P + W+ N
Sbjct: 238 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 297
Query: 339 GQPLRESKIIHVEYYQEGEIS----EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGH 394
G + +++ + I+ E LFN T + G Y N +G ANQ
Sbjct: 298 GSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV-TEADAGEYICKVSNYIGQANQ----- 351
Query: 395 FLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMIN 454
S +L + +P +T P+ + +G+ AC+++ V+ +
Sbjct: 352 --------SAWLTVLPKQQAPGREKEITASPDYLEIAI-YCIGVFLIACMVVTVILCRMK 402
Query: 455 KYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDAGPDTVVI- 503
++ F + V ++ +S+S ++ + + L + DT ++
Sbjct: 403 NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA 462
Query: 504 GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPT 563
G++ + E+P++ R + L + LGEG FG+V +AE +
Sbjct: 463 GVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
Query: 564 KDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619
K K + VAVK LKD T D E E++ + +H++I+ G C PL ++ EY
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567
Query: 620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRD 679
G+L ++LRA P M R + ++ ++ Q+A GM YLASQ +HRD
Sbjct: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627
Query: 680 LATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 739
LA RN LV N ++KI DFG++RD+ + DYY+ + LP++WM PE++ R +T +SDV
Sbjct: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 687
Query: 740 WSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQ 799
WSFGV++WEIFT G P+ + E+ + + +G +++P C E+Y +M CW P Q
Sbjct: 688 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 747
Query: 800 RLNIKEIYKILHALGKAT--PIYLDI 823
R K++ + L + T YLD+
Sbjct: 748 RPTFKQLVEDLDRILTLTTNEEYLDL 773
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 222 bits (566), Expect = 1e-57
Identities = 166/611 (27%), Positives = 279/611 (45%), Gaps = 62/611 (10%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C G+P+P + W+ G + H+ +L + +V D G TC+ EN
Sbjct: 90 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 148
Query: 291 GMSNASVALTVYYPPRVVSLEEPELRLEHC------IEFV--VRGNPPPTLHWLH----N 338
G N + L V + + L +EFV V + P + W+ N
Sbjct: 149 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 208
Query: 339 GQPLRESKIIHVEYYQEGEIS----EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGH 394
G + +++ + I+ E LFN T + G Y N +G ANQ
Sbjct: 209 GSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV-TEADAGEYICKVSNYIGQANQ----- 262
Query: 395 FLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMIN 454
S +L + +P +T P+ + +G+ AC+++ V+ +
Sbjct: 263 --------SAWLTVLPKQQAPGREKEITASPDYLEIAI-YCIGVFLIACMVVTVILCRMK 313
Query: 455 KYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDAGPDTVVI- 503
++ F + V ++ +S+S ++ + + L + DT ++
Sbjct: 314 NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA 373
Query: 504 GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPT 563
G++ + E+P++ R + L + LGEG FG+V +AE +
Sbjct: 374 GVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 418
Query: 564 KDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619
K K + VAVK LKD T D E E++ + +H++I+ G C PL ++ EY
Sbjct: 419 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 478
Query: 620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRD 679
G+L ++LRA P M R + ++ ++ Q+A GM YLASQ +HRD
Sbjct: 479 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 538
Query: 680 LATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 739
LA RN LV N ++KI DFG++RD+ + DYY+ + LP++WM PE++ R +T +SDV
Sbjct: 539 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 598
Query: 740 WSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQ 799
WSFGV++WEIFT G P+ + E+ + + +G +++P C E+Y +M CW P Q
Sbjct: 599 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 658
Query: 800 RLNIKEIYKIL 810
R K++ + L
Sbjct: 659 RPTFKQLVEDL 669
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 222 bits (566), Expect = 1e-57
Identities = 166/611 (27%), Positives = 279/611 (45%), Gaps = 62/611 (10%)
Query: 231 CNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVV 290
C G+P+P + W+ G + H+ +L + +V D G TC+ EN
Sbjct: 179 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKG-NYTCVVENEY 237
Query: 291 GMSNASVALTVYYPPRVVSLEEPELRLEHC------IEFV--VRGNPPPTLHWLH----N 338
G N + L V + + L +EFV V + P + W+ N
Sbjct: 238 GSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKN 297
Query: 339 GQPLRESKIIHVEYYQEGEIS----EGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGH 394
G + +++ + I+ E LFN T + G Y N +G ANQ
Sbjct: 298 GSKYGPDGLPYLKVLKHSGINSSNAEVLALFNV-TEADAGEYICKVSNYIGQANQ----- 351
Query: 395 FLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMIN 454
S +L + +P +T P+ + +G+ AC+++ V+ +
Sbjct: 352 --------SAWLTVLPKQQAPGREKEITASPDYLEIAI-YCIGVFLIACMVVTVILCRMK 402
Query: 455 KYGRRSKFGMKGPV----------AVISGEEDSASPLHHINHGITTPSSLDAGPDTVVI- 503
++ F + V ++ +S+S ++ + + L + DT ++
Sbjct: 403 NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLA 462
Query: 504 GMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPT 563
G++ + E+P++ R + L + LGEG FG+V +AE +
Sbjct: 463 GVSEYELPEDPKW---------------EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKD 507
Query: 564 KDK--MLVAVKALKDP-TLAARKDFQREAELLTNL-QHEHIVKFYGVCGDGDPLIMVFEY 619
K K + VAVK LKD T D E E++ + +H++I+ G C PL ++ EY
Sbjct: 508 KPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 567
Query: 620 MKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRD 679
G+L ++LRA P M R + ++ ++ Q+A GM YLASQ +HRD
Sbjct: 568 ASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 627
Query: 680 LATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 739
LA RN LV N ++KI DFG++RD+ + DYY+ + LP++WM PE++ R +T +SDV
Sbjct: 628 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 687
Query: 740 WSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQ 799
WSFGV++WEIFT G P+ + E+ + + +G +++P C E+Y +M CW P Q
Sbjct: 688 WSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQ 747
Query: 800 RLNIKEIYKIL 810
R K++ + L
Sbjct: 748 RPTFKQLVEDL 758
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,101,442
Number of Sequences: 37866
Number of extensions: 1599105
Number of successful extensions: 7878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 391
Number of HSP's that attempted gapping in prelim test: 3306
Number of HSP's gapped (non-prelim): 2827
length of query: 825
length of database: 18,247,518
effective HSP length: 111
effective length of query: 714
effective length of database: 14,044,392
effective search space: 10027695888
effective search space used: 10027695888
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.