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Search of human proteins with 59889558
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59889558 neurotrophic tyrosine kinase, receptor, type 1
isoform 1 [Homo sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 1624 0.0
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 1617 0.0
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 1471 0.0
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 747 0.0
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 737 0.0
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 719 0.0
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 709 0.0
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 285 9e-77
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo... 279 8e-75
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo... 257 3e-68
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 251 2e-66
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo... 247 3e-65
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 244 3e-64
gi|62420886 discoidin domain receptor family, member 2 precursor... 244 3e-64
gi|62420884 discoidin domain receptor family, member 2 precursor... 244 3e-64
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 238 2e-62
gi|38327632 discoidin domain receptor family, member 1 isoform b... 238 2e-62
gi|83977450 discoidin domain receptor family, member 1 isoform a... 238 2e-62
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 237 3e-62
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 237 4e-62
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 237 4e-62
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo... 234 2e-61
gi|83977452 discoidin domain receptor family, member 1 isoform c... 231 2e-60
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 230 3e-60
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 227 3e-59
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 226 8e-59
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 226 8e-59
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 224 2e-58
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 224 2e-58
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 224 2e-58
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 1624 bits (4205), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
Sbjct: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
Query: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
Sbjct: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
Query: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
Sbjct: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
Query: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
Sbjct: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
Query: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
Sbjct: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
Query: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAV 420
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAV
Sbjct: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAV 420
Query: 421 FACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL 480
FACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL
Sbjct: 421 FACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL 480
Query: 481 QGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL 540
QGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL
Sbjct: 481 QGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKAL 540
Query: 541 KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP
Sbjct: 541 KEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI
Sbjct: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ
Sbjct: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
Query: 721 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 780
PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ
Sbjct: 721 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 780
Query: 781 APPVYLDVLG 790
APPVYLDVLG
Sbjct: 781 APPVYLDVLG 790
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 1617 bits (4188), Expect = 0.0
Identities = 790/796 (99%), Positives = 790/796 (99%), Gaps = 6/796 (0%)
Query: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
Sbjct: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
Query: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
Sbjct: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
Query: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
Sbjct: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
Query: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
Sbjct: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
Query: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
Sbjct: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
Query: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIP------DTNSTSGDPVEKKDETPFGVSV 414
LLAANPFGQASASIMAAFMDNPFEFNPEDPIP DTNSTSGDPVEKKDETPFGVSV
Sbjct: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV 420
Query: 415 AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE 474
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
Sbjct: 421 AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE 480
Query: 475 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 534
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
Sbjct: 481 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 540
Query: 535 VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF 594
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
Sbjct: 541 VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF 600
Query: 595 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 654
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
Sbjct: 601 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660
Query: 655 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 714
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
Sbjct: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720
Query: 715 FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 774
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
Sbjct: 721 FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 780
Query: 775 LQALAQAPPVYLDVLG 790
LQALAQAPPVYLDVLG
Sbjct: 781 LQALAQAPPVYLDVLG 796
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 1471 bits (3809), Expect = 0.0
Identities = 720/723 (99%), Positives = 720/723 (99%)
Query: 68 LTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 127
L YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL
Sbjct: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
Query: 128 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 187
ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP
Sbjct: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 157
Query: 188 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 247
NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL
Sbjct: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
Query: 248 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 307
GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG
Sbjct: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 277
Query: 308 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 367
QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF
Sbjct: 278 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 337
Query: 368 GQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLS 427
GQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLS
Sbjct: 338 GQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLS 397
Query: 428 TLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIEN 487
TLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIEN
Sbjct: 398 TLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIEN 457
Query: 488 PQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 547
PQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
Sbjct: 458 PQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 517
Query: 548 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 607
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG
Sbjct: 518 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 577
Query: 608 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 667
GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
Sbjct: 578 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 637
Query: 668 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 727
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN
Sbjct: 638 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 697
Query: 728 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 787
TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD
Sbjct: 698 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 757
Query: 788 VLG 790
VLG
Sbjct: 758 VLG 760
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 747 bits (1928), Expect = 0.0
Identities = 399/752 (53%), Positives = 503/752 (66%), Gaps = 29/752 (3%)
Query: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
Query: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
Query: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
Query: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
Query: 357 GNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVS 413
GNYTL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS
Sbjct: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVS 433
Query: 414 VAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSP 472
+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S
Sbjct: 434 IAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSS 493
Query: 473 TE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVF 519
+ G + + G +IENPQYF D V HIKRRDIVLK ELGEGAFGKVF
Sbjct: 494 LDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVF 553
Query: 520 LAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPL 579
LAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL
Sbjct: 554 LAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPL 613
Query: 580 LMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGL 638
+MVFEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +ASQ+A+GMVYLA
Sbjct: 614 IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ 673
Query: 639 HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKF 698
HFVHRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYRVGG TMLPIRWMPPESI+YRKF
Sbjct: 674 HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKF 733
Query: 699 TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW 758
TTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR CP EVY +M GCW
Sbjct: 734 TTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 793
Query: 759 QREPQQRHSIKDVHARLQALAQAPPVYLDVLG 790
QREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 794 QREPQQRLNIKEIYKILHALGKATPIYLDILG 825
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 737 bits (1903), Expect = 0.0
Identities = 399/766 (52%), Positives = 503/766 (65%), Gaps = 43/766 (5%)
Query: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
Query: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
Query: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
Query: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
Query: 357 GNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVS 413
GNYTL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS
Sbjct: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVS 433
Query: 414 VAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSP 472
+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S
Sbjct: 434 IAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSS 493
Query: 473 TE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVF 519
+ G + + G +IENPQYF D V HIKRRDIVLK ELGEGAFGKVF
Sbjct: 494 LDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVF 553
Query: 520 LAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPL 579
LAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL
Sbjct: 554 LAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPL 613
Query: 580 LMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGL 638
+MVFEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +ASQ+A+GMVYLA
Sbjct: 614 IMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ 673
Query: 639 HFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR--------------VGGRTMLP 684
HFVHRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYR VGG TMLP
Sbjct: 674 HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLP 733
Query: 685 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 744
IRWMPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR
Sbjct: 734 IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR 793
Query: 745 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 790
CP EVY +M GCWQREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 794 VCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 719 bits (1855), Expect = 0.0
Identities = 405/827 (48%), Positives = 520/827 (62%), Gaps = 59/827 (7%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408
+YTL+A N +G+ I A FM D+ N D I + T+ GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 409 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFGINRPA-VLAPEDGL 456
P V+ G L+V+A + ++++ +L L K R +KFG+ PA V++ +D
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDS 477
Query: 457 AMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACVHHIKRRD 503
A LH ++ G ++ S +EG + + +IENPQYF D V HIKR +
Sbjct: 478 ASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHN 537
Query: 504 IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQH 563
IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAELLT LQH
Sbjct: 538 IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH 597
Query: 564 QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 623
+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L Q+L
Sbjct: 598 EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTELTQSQMLH 655
Query: 624 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 683
+A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYRVGG TML
Sbjct: 656 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 715
Query: 684 PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP 743
PIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQGR L+RP
Sbjct: 716 PIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 775
Query: 744 RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 790
R CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 776 RTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 709 bits (1830), Expect = 0.0
Identities = 403/843 (47%), Positives = 519/843 (61%), Gaps = 75/843 (8%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408
+YTL+A N +G+ I A FM D+ N D I + T+ GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 409 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFG-------------- 443
P V+ G L+V+A + ++++ +L L K R +KFG
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
Query: 444 ---INRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--- 492
+ +V++ +D A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITN 537
Query: 493 -----DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 547
D V HIKR +IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++A
Sbjct: 538 SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA 597
Query: 548 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 607
R+DF REAELLT LQH+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A
Sbjct: 598 RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAE 657
Query: 608 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 667
G P L Q+L +A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSR
Sbjct: 658 GNP--PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 715
Query: 668 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 727
D+YSTDYYRVGG TMLPIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN
Sbjct: 716 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 775
Query: 728 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 787
E I+CITQGR L+RPR CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD
Sbjct: 776 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLD 835
Query: 788 VLG 790
+LG
Sbjct: 836 ILG 838
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 285 bits (730), Expect = 9e-77
Identities = 143/290 (49%), Positives = 186/290 (64%), Gaps = 10/290 (3%)
Query: 501 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLT 559
R +I ++GEGAFG+VF A LLP + +VAVK LKE AS + DFQREA L+
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
Query: 560 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---------DAKLLAGGED 610
+ +IV+ GVC G+P+ ++FEYM +GDLN FLRS P D + A
Sbjct: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
Query: 611 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 670
P PL + L +A QVAAGM YL+ FVHRDLATRNCLVG+ +VVKI DFG+SR+IY
Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
Query: 671 STDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 730
S DYY+ +PIRWMPPESI Y ++TTESDVW++GVVLWEIF+YG QP+Y +++ E
Sbjct: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
Query: 731 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 780
I + G L P CP E+Y +MR CW + P R S +H L+ + +
Sbjct: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861
Score = 35.0 bits (79), Expect = 0.27
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 198 VQVPNASVD--VGDDVLLRCQVEGRGLEQAGW----ILTEL-EQSATVMKSGGLPSLGLT 250
+ P +VD V + C VE + W IL +L + ++ ++G L LT
Sbjct: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQL----LT 85
Query: 251 LANVTSDLNRKNVTCWAENDVGRAEVS---VQVNVSF-----PASVQLHTAVEMHHWCIP 302
+ +V D + C A N VG A S +QV + P +V++ +E +P
Sbjct: 86 ILSV-EDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKI---IEGLKAVLP 141
Query: 303 FSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLL 362
+ G P PS+ W+ S L E S I + G LR++ + G Y +
Sbjct: 142 CTTMGNPKPSVSWIKGDSPLRENSRI----------AVLESGSLRIHNVQKEDAGQYRCV 191
Query: 363 AANPFGQASASIM 375
A N G A + ++
Sbjct: 192 AKNSLGTAYSKVV 204
Score = 33.9 bits (76), Expect = 0.60
Identities = 43/201 (21%), Positives = 80/201 (39%), Gaps = 26/201 (12%)
Query: 190 SCGVPTLKVQVP------NASVDVGDDVLLRCQVEGRGLEQAGWILTE--LEQSATVMKS 241
SCG +K++ N + G +L C G WI + L +++ +
Sbjct: 111 SCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV- 169
Query: 242 GGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-----EVSVQVNVSFPASVQLHTAVEM 296
L S L + NV + + C A+N +G A ++ V+V + + H
Sbjct: 170 --LESGSLRIHNVQKE-DAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
Query: 297 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
+ + G P P++ W+ NG+ ++ S ++ + + V L+L
Sbjct: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGS------IQESVKDRVIDSRLQL---FITKP 277
Query: 357 GNYTLLAANPFGQASASIMAA 377
G YT +A N G+ ++ AA
Sbjct: 278 GLYTCIATNKHGEKFSTAKAA 298
>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
c precursor [Homo sapiens]
Length = 612
Score = 279 bits (713), Expect = 8e-75
Identities = 172/444 (38%), Positives = 242/444 (54%), Gaps = 20/444 (4%)
Query: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
Query: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
Query: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
Query: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEG---EISEGCLLFNKPTHYNN 373
Query: 357 GNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVS 413
GNYTL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS
Sbjct: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVS 433
Query: 414 VAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSP 472
+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S
Sbjct: 434 IAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSS 493
Query: 473 TE-GKGSGLQG----HIIENPQYF 491
+ G + + G +IENPQYF
Sbjct: 494 LDAGPDTVVIGMTRIPVIENPQYF 517
>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
e precursor [Homo sapiens]
Length = 537
Score = 257 bits (656), Expect = 3e-68
Identities = 180/520 (34%), Positives = 266/520 (51%), Gaps = 49/520 (9%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408
+YTL+A N +G+ I A FM D+ N D I + T+ GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 409 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKFGINRPA-VLAPEDGL 456
P V+ G L+V+A + +++ ++L L K R +KFG+ PA V++ +D
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDS 477
Query: 457 AMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 491
A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 478 ASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 517
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 251 bits (641), Expect = 2e-66
Identities = 128/273 (46%), Positives = 177/273 (64%), Gaps = 6/273 (2%)
Query: 509 ELGEGAFGKVFLAECHNLLPEQDK-MLVAVKALKEASESAR-QDFQREAELLTMLQHQHI 566
ELGE AFGK++ H LP D LVA+K LK+ + + +FQ+EA L+ L H +I
Sbjct: 478 ELGECAFGKIYKG--HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNI 535
Query: 567 VRFFGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAV 624
V G T+ +P+ M+FEY+ GDL+ FL RS D + + L G L +
Sbjct: 536 VCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
Query: 625 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 684
A Q+AAGM YL+ FVH+DLA RN L+G+ L VKI D G+SR+IYS DYYRV +++LP
Sbjct: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLP 655
Query: 685 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 744
IRWMPPE+I+Y KF+++SD+WSFGVVLWEIF++G QP+Y SN E I+ + + + L
Sbjct: 656 IRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSE 715
Query: 745 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 777
CPP +Y++M CW P +R KD+H RL++
Sbjct: 716 DCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS 748
>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
d precursor [Homo sapiens]
Length = 553
Score = 247 bits (631), Expect = 3e-65
Identities = 178/536 (33%), Positives = 265/536 (49%), Gaps = 65/536 (12%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408
+YTL+A N +G+ I A FM D+ N D I + T+ GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 409 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKF--------------- 442
P V+ G L+V+A + +++ ++L L K R +KF
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
Query: 443 --GINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 491
G+ +V++ +D A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 533
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 244 bits (622), Expect = 3e-64
Identities = 124/291 (42%), Positives = 178/291 (61%), Gaps = 11/291 (3%)
Query: 487 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
NP+YFS A V+ + R I + ELG+G+FG V+ ++ ++ + VA+K +
Sbjct: 977 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN 1036
Query: 542 EA-SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
EA S R +F EA ++ H+VR GV ++G+P L++ E M GDL +LRS P
Sbjct: 1037 EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 1096
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
+ + + P L +++ +A ++A GM YL FVHRDLA RNC+V + VKI
Sbjct: 1097 EME-----NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 1151
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
GDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 1152 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 1211
Query: 721 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771
P+ LSN + + + +G L++P CP ++ +MR CWQ P+ R S ++
Sbjct: 1212 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 244 bits (622), Expect = 3e-64
Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%)
Query: 493 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 541
D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 542 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
+A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
+ DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI
Sbjct: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 719
DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ +
Sbjct: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786
Query: 720 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772
QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H
Sbjct: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846
Query: 773 ARL 775
L
Sbjct: 847 LLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 244 bits (622), Expect = 3e-64
Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%)
Query: 493 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 541
D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 542 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
+A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
+ DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI
Sbjct: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 719
DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ +
Sbjct: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786
Query: 720 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772
QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H
Sbjct: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846
Query: 773 ARL 775
L
Sbjct: 847 LLL 849
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 238 bits (607), Expect = 2e-62
Identities = 119/271 (43%), Positives = 169/271 (62%), Gaps = 2/271 (0%)
Query: 509 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTMLQHQHIV 567
ELGE FGKV+ P + VA+K LK+ +E R++F+ EA L LQH ++V
Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
Query: 568 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVAS 626
GV T+ +PL M+F Y HGDL+ FL P + + + +D L + + +
Sbjct: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
Query: 627 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 686
Q+AAGM YL+ H VH+DLATRN LV L VKI D G+ R++Y+ DYY++ G ++LPIR
Sbjct: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
Query: 687 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 746
WM PE+I+Y KF+ +SD+WS+GVVLWE+F+YG QP+ SN + ++ I + L P C
Sbjct: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
Query: 747 PPEVYAIMRGCWQREPQQRHSIKDVHARLQA 777
P VYA+M CW P +R KD+H+RL+A
Sbjct: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRA 748
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 501 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 548
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
Query: 549 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 608
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
Query: 609 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 664
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749
Query: 665 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 723
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809
Query: 724 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 501 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 548
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 666
Query: 549 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 608
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 667 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 726
Query: 609 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 664
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 727 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 786
Query: 665 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 723
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 787 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 846
Query: 724 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 847 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 902
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 237 bits (605), Expect = 3e-62
Identities = 127/296 (42%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 487 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
NP+YFS + ++ + R I + ELG+G+FG V+ L ++ VA+K +
Sbjct: 957 NPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN 1016
Query: 542 E-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
E AS +F +EA ++ + H+VR GV ++G+P L++ E M GDL LRS P
Sbjct: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
+A+ G P P LG+++ +A ++A GM YLA FVHRDLA RNC+V Q VKI
Sbjct: 1077 EAENNPG----LPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKI 1131
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
GDFGM+RD+Y TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 1132 GDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQ 1191
Query: 721 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 776
P+ LSN + + + G LE CP ++ +M CWQ P+ R S + +Q
Sbjct: 1192 PYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 237 bits (604), Expect = 4e-62
Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)
Query: 487 NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 536
NP+Y S + V + R I L ELG+G+FG V+ +++ + + VA
Sbjct: 984 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1043
Query: 537 VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 595
VK + E AS R +F EA ++ H+VR GV ++G+P L+V E M HGDL +L
Sbjct: 1044 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1103
Query: 596 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 655
RS P+A+ G P L +++ +A+++A GM YL FVHRDLA RNC+V
Sbjct: 1104 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
Query: 656 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 715
VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SD+WSFGVVLWEI
Sbjct: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
Query: 716 TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771
+ +QP+ LSN + + + G L++P CP V +MR CWQ P+ R + ++
Sbjct: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1274
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 237 bits (604), Expect = 4e-62
Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)
Query: 487 NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 536
NP+Y S + V + R I L ELG+G+FG V+ +++ + + VA
Sbjct: 996 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1055
Query: 537 VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 595
VK + E AS R +F EA ++ H+VR GV ++G+P L+V E M HGDL +L
Sbjct: 1056 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1115
Query: 596 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 655
RS P+A+ G P L +++ +A+++A GM YL FVHRDLA RNC+V
Sbjct: 1116 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1170
Query: 656 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 715
VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SD+WSFGVVLWEI
Sbjct: 1171 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1230
Query: 716 TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771
+ +QP+ LSN + + + G L++P CP V +MR CWQ P+ R + ++
Sbjct: 1231 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1286
>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
b precursor [Homo sapiens]
Length = 477
Score = 234 bits (598), Expect = 2e-61
Identities = 162/467 (34%), Positives = 237/467 (50%), Gaps = 43/467 (9%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408
+YTL+A N +G+ I A FM D+ N D I + T+ GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 409 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKFGI 444
P V+ G L+V+A + +++ ++L L K R +KFG+
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGM 464
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 231 bits (589), Expect = 2e-60
Identities = 134/302 (44%), Positives = 185/302 (61%), Gaps = 30/302 (9%)
Query: 501 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESA- 547
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++A
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAS 666
Query: 548 -----RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 602
R DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H +
Sbjct: 667 FSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 726
Query: 603 KLLAGGE---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV 658
K G A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +
Sbjct: 727 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 786
Query: 659 KIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 718
KI DFGMSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+
Sbjct: 787 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 846
Query: 719 K-QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD 770
+ QP+ QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR
Sbjct: 847 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 906
Query: 771 VH 772
+H
Sbjct: 907 LH 908
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 230 bits (587), Expect = 3e-60
Identities = 122/290 (42%), Positives = 166/290 (57%), Gaps = 12/290 (4%)
Query: 499 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-SESARQDFQREAEL 557
+ R++I L LG GAFG+V+ + + + + VAVK L E SE DF EA +
Sbjct: 1111 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 1170
Query: 558 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 617
++ HQ+IVR GV + P ++ E M GDL FLR P P L
Sbjct: 1171 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPSSLA 1222
Query: 618 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDY 674
+ LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY Y
Sbjct: 1223 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1282
Query: 675 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 734
YR GG MLP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ SN E ++ +
Sbjct: 1283 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1342
Query: 735 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV 784
T G ++ P+ CP VY IM CWQ +P+ R + + R++ Q P V
Sbjct: 1343 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV 1392
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 227 bits (579), Expect = 3e-59
Identities = 174/587 (29%), Positives = 270/587 (45%), Gaps = 50/587 (8%)
Query: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 257
SV+V D RC AG I E + V+ LP L A VT D
Sbjct: 470 SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
Query: 258 LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 312
+ N TC A N +++V V ++F + T + H + G P P
Sbjct: 524 -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
Query: 313 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 372
++W +L+ T L P + ++G L ++ ++G YT +A N
Sbjct: 583 IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
Query: 373 SIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLV 432
+D P +P+ + G P K G+SV +A ++ +L +
Sbjct: 636 EAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA-----YIIAVLGL 682
Query: 433 LNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQY 490
+ C +R K +P PE S+ E + L +
Sbjct: 683 MFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 742
Query: 491 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 550
S + H R + LG+ FG+VFLA+ L + LV VK+L+ E + D
Sbjct: 743 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 802
Query: 551 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGE 609
F+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S D KL +
Sbjct: 803 FRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS--- 859
Query: 610 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 669
PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+ G+S+D+
Sbjct: 860 ----QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
Query: 670 YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 729
Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+ P ++ E
Sbjct: 916 YNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
Query: 730 AIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775
+ + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 975 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 371 SAS 373
+S
Sbjct: 210 CSS 212
Score = 30.8 bits (68), Expect = 5.1
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)
Query: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
Query: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
Query: 362 LAANPFGQASASIMAAFMD 380
+++ P G A +D
Sbjct: 482 MSSTPAGSIEAQARVQVLD 500
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 226 bits (575), Expect = 8e-59
Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)
Query: 249 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 555 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 613
Query: 304 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 614 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 666
Query: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 423
N +D P +P+ + G P K G+SV +A
Sbjct: 667 GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 714
Query: 424 LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 481
++ +L ++ C +R K +P PE S+ E + L
Sbjct: 715 -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 773
Query: 482 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 774 SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 833
Query: 542 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 600
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S
Sbjct: 834 SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 893
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 894 DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 946
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+
Sbjct: 947 SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
Query: 721 PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775
P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 371 SAS 373
+S
Sbjct: 210 CSS 212
Score = 30.0 bits (66), Expect = 8.7
Identities = 32/146 (21%), Positives = 56/146 (38%), Gaps = 22/146 (15%)
Query: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
Query: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
Query: 362 LAANPFGQASASIMAAFMDNPFEFNP 387
+++ P G A ++ +F P
Sbjct: 482 MSSTPAGSIEAQARVQVLEK-LKFTP 506
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 226 bits (575), Expect = 8e-59
Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)
Query: 249 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 425 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 483
Query: 304 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 484 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 536
Query: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 423
N +D P +P+ + G P K G+SV +A
Sbjct: 537 GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 584
Query: 424 LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 481
++ +L ++ C +R K +P PE S+ E + L
Sbjct: 585 -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 643
Query: 482 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 644 SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 703
Query: 542 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 600
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S
Sbjct: 704 SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 763
Query: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 764 DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 816
Query: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+
Sbjct: 817 SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 875
Query: 721 PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775
P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 876 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 371 SAS 373
+S
Sbjct: 210 CSS 212
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 496 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 554
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
Query: 555 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 614
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 613
Query: 615 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 671
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
Query: 672 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 731
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
Query: 732 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 789
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 791
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 496 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 554
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 441 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 500
Query: 555 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 614
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 501 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 552
Query: 615 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 671
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 553 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 612
Query: 672 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 731
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 613 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 672
Query: 732 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 789
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 673 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 730
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 224 bits (571), Expect = 2e-58
Identities = 186/621 (29%), Positives = 276/621 (44%), Gaps = 60/621 (9%)
Query: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGL----PSLGLTLANVTSDLN 259
+V G+ V RC G W L + + + GG+ L + +V +
Sbjct: 161 AVPAGNTVKFRCPAAGNPTPTIRW-LKDGQAFHGENRIGGIRLRHQHWSLVMESVVPS-D 218
Query: 260 RKNVTCWAENDVGRAEVSVQVNV------------SFPASVQLHTAVEMHHWCIPFSVDG 307
R TC EN VG + ++V PA+ ++ C +S D
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS-DA 277
Query: 308 QPAPSLRWL----FNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
QP ++WL NGS F + + L+ A + L L + + G YT LA
Sbjct: 278 QP--HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 423
N G + S + P D T+ P + + S ++ LAV
Sbjct: 336 GNSIGLSYQSAWLTVL----------PEEDPTWTAAAPEARYTDIILYASGSLALAVL-- 383
Query: 424 LFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGH 483
L L+ L GR + PA + ++ F GSS + G++
Sbjct: 384 LLLAGLYRGQALHGRHPR----PPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLS 439
Query: 484 IIENPQYFSDAC--------VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML- 534
P + + R +VL LGEG FG+V AE + P +
Sbjct: 440 S-SGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 498
Query: 535 -VAVKALKE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDL 591
VAVK LK+ AS+ D E E++ ++ +H++I+ GVCT+ PL ++ E G+L
Sbjct: 499 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 558
Query: 592 NRFLRSH---GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR 648
FLR+ GPD L G + GPL L++ A QVA GM YL +HRDLA R
Sbjct: 559 REFLRARRPPGPD--LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 616
Query: 649 NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG 708
N LV + V+KI DFG++R ++ DYY+ LP++WM PE++ R +T +SDVWSFG
Sbjct: 617 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 676
Query: 709 VVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI 768
++LWEIFT G P+ + E + +G ++RP CPPE+Y +MR CW P QR +
Sbjct: 677 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 769 KD-VHARLQALAQAPPVYLDV 788
K V A + L YLD+
Sbjct: 737 KQLVEALDKVLLAVSEEYLDL 757
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,845,395
Number of Sequences: 37866
Number of extensions: 1568868
Number of successful extensions: 7282
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 589
Number of HSP's successfully gapped in prelim test: 394
Number of HSP's that attempted gapping in prelim test: 4191
Number of HSP's gapped (non-prelim): 2062
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.