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Search of human proteins with 59823631
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|59823631 G protein-coupled receptor 125 [Homo sapiens]
(1321 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|59823631 G protein-coupled receptor 125 [Homo sapiens] 2676 0.0
gi|194272183 G protein-coupled receptor 124 [Homo sapiens] 963 0.0
gi|144922665 G protein-coupled receptor 123 [Homo sapiens] 414 e-115
gi|59710093 G-protein coupled receptor 112 [Homo sapiens] 125 3e-28
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 120 9e-27
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 118 4e-26
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 118 4e-26
gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom... 114 6e-25
gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom... 114 6e-25
gi|45433552 G protein-coupled receptor 133 [Homo sapiens] 110 9e-24
gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens] 110 9e-24
gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens] 110 9e-24
gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens] 110 9e-24
gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens] 110 9e-24
gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Ho... 108 3e-23
gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Ho... 108 3e-23
gi|188528675 slit homolog 1 [Homo sapiens] 108 4e-23
gi|109150416 peroxidasin [Homo sapiens] 107 1e-22
gi|6912464 latrophilin 2 precursor [Homo sapiens] 107 1e-22
gi|11321571 slit homolog 3 [Homo sapiens] 103 1e-21
gi|163792198 latrophilin 3 precursor [Homo sapiens] 103 1e-21
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 102 2e-21
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 102 2e-21
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 102 3e-21
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 101 4e-21
gi|4759146 slit homolog 2 [Homo sapiens] 100 9e-21
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 98 5e-20
gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens] 98 6e-20
gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens] 98 6e-20
gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens] 97 1e-19
>gi|59823631 G protein-coupled receptor 125 [Homo sapiens]
Length = 1321
Score = 2676 bits (6936), Expect = 0.0
Identities = 1321/1321 (100%), Positives = 1321/1321 (100%)
Query: 1 MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAE 60
MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAE
Sbjct: 1 MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAE 60
Query: 61 GKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSI 120
GKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSI
Sbjct: 61 GKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSI 120
Query: 121 DPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLR 180
DPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLR
Sbjct: 121 DPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLR 180
Query: 181 SLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLE 240
SLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLE
Sbjct: 181 SLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLE 240
Query: 241 LPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIH 300
LPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIH
Sbjct: 241 LPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIH 300
Query: 301 NCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGD 360
NCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGD
Sbjct: 301 NCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGD 360
Query: 361 FRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYANDV 420
FRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYANDV
Sbjct: 361 FRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYANDV 420
Query: 421 TRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSK 480
TRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSK
Sbjct: 421 TRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSK 480
Query: 481 ELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTYSPNI 540
ELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTYSPNI
Sbjct: 481 ELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTYSPNI 540
Query: 541 ALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSL 600
ALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSL
Sbjct: 541 ALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSNTFSSL 600
Query: 601 ALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDG 660
ALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDG
Sbjct: 601 ALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDG 660
Query: 661 KRRTVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAARWDFDLLNGQGGWKSDGC 720
KRRTVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAARWDFDLLNGQGGWKSDGC
Sbjct: 661 KRRTVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAARWDFDLLNGQGGWKSDGC 720
Query: 721 HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS 780
HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS
Sbjct: 721 HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS 780
Query: 781 YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATV 840
YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATV
Sbjct: 781 YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATV 840
Query: 841 LWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNY 900
LWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNY
Sbjct: 841 LWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNY 900
Query: 901 GSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQ 960
GSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQ
Sbjct: 901 GSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQ 960
Query: 961 RLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLY 1020
RLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLY
Sbjct: 961 RLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLY 1020
Query: 1021 YPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSN 1080
YPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSN
Sbjct: 1021 YPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSN 1080
Query: 1081 GTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDN 1140
GTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDN
Sbjct: 1081 GTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDN 1140
Query: 1141 SLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEG 1200
SLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEG
Sbjct: 1141 SLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEG 1200
Query: 1201 SVQNGLPKSRLGNNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTT 1260
SVQNGLPKSRLGNNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTT
Sbjct: 1201 SVQNGLPKSRLGNNEGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTT 1260
Query: 1261 SKKDALRKPAVVELENQQKSYGLNLAIQNGPIKSNGQEGPLLGTDSTGNVRTGLWKHETT 1320
SKKDALRKPAVVELENQQKSYGLNLAIQNGPIKSNGQEGPLLGTDSTGNVRTGLWKHETT
Sbjct: 1261 SKKDALRKPAVVELENQQKSYGLNLAIQNGPIKSNGQEGPLLGTDSTGNVRTGLWKHETT 1320
Query: 1321 V 1321
V
Sbjct: 1321 V 1321
>gi|194272183 G protein-coupled receptor 124 [Homo sapiens]
Length = 1338
Score = 963 bits (2490), Expect = 0.0
Identities = 588/1370 (42%), Positives = 796/1370 (58%), Gaps = 89/1370 (6%)
Query: 5 GRRRGRAQPPLLLPLS--LLALLALLGGGGGGGAAALPAGCKHDG-RPRG-AGRAAGAAE 60
GRR A LLLPL LL LLA G G ++ + CK G RP+G +G G A
Sbjct: 5 GRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRS-CKCSGERPKGLSGGVPGPAR 63
Query: 61 GKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSI 120
+VVCS +L + P LPN TVTL+LSNNKI+ L+NGSF GLSLLE+LDLRNN+IS++
Sbjct: 64 RRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTV 123
Query: 121 DPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLR 180
PGAF GL LKRLDL+NNRIGCL ++ F+GL L+RLN+SGN+FSSL G FD L +L+
Sbjct: 124 QPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALK 183
Query: 181 SLEFQTEYLLCDCNILWMHRWVKEKNITVRD-TRCVYPKSLQAQPVTGVKQELLTCDPPL 239
++ TE+L CDC++ W+ W + +++ + + T C YP +L AQ + +++ L C+ L
Sbjct: 184 VVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGAL 243
Query: 240 ELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMI 299
EL + ++ PS RQVVF+GD LPFQC ASY+ D ++ WY + VE DE GI + +++I
Sbjct: 244 ELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLI 303
Query: 300 HNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKG 359
H+C+ I S LT+S+I ++G W C V +GN ++ V+IVVLE+SA YCP ERV NN+G
Sbjct: 304 HDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRG 363
Query: 360 DFRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYAND 419
DFRWPRTLAGITAY C + S + G +A RRCDR G W DYS C Y ND
Sbjct: 364 DFRWPRTLAGITAYQSCLQYPFTS-VPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTND 422
Query: 420 VTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKS 479
+TRVLY F MP+N +NA+ A QL YT EAA+FSD MDV++VA+MI+KF + ++
Sbjct: 423 ITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYV--DQI 480
Query: 480 KELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTYSPN 539
KEL +VMVD+ASN+ML DE +LWLAQRE KACSRIV L+RI L+ A S + N
Sbjct: 481 KELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARN 540
Query: 540 IALEAYVIKSTGFTGMTCTVFQK----VAASDRTGLSDYGRRDPEGNLDKQLSFKCNVSN 595
+ALEAY+IK + G+TCT FQ+ V + +PE D+QL F+C
Sbjct: 541 VALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGR 600
Query: 596 ---TFSSLALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGN 652
+ SS +KN++ ASIQLPPSLFS L P LQL+ FRNG+LF + N
Sbjct: 601 PNVSLSSFHIKNSVALASIQLPPSLFS-SLPAALAPPVPPDCTLQLLVFRNGRLFHSHSN 659
Query: 653 ST--NLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAARWDFDLLN 710
++ A GKRR V TPVI G V PV V+LR A GA+ VAA W +
Sbjct: 660 TSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPG 719
Query: 711 GQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASL-LHPVVYTTAII 769
GGW S+GC + S N++ + C L N AVLM+L+ A LHPVVY +
Sbjct: 720 EAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTAL 779
Query: 770 LLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVG 829
LLLCL A I++YI +HS IR+S K WHML+NLCFHI +T VF GGIT T +CQAVG
Sbjct: 780 LLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVG 839
Query: 830 IILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVC 889
I LHYS+L+T+LW+GV AR ++K++T +A Q+ D P P PMLRFYLI GGIP+I+C
Sbjct: 840 ITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIIC 899
Query: 890 GITAAANIKNYGSRPNAPYCWMAWEPSLGAFYGPASFITFVNCMYFLSIFIQLK----RH 945
GITAA NI NY R ++PYCW+ W PSLGAFY P + I + +YFL ++L+ ++
Sbjct: 900 GITAAVNIHNY--RDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQN 957
Query: 946 PE---RKYELKEPTEEQQRLAANENGEINHQDSMSLSLISTSAL--------ENEHTFHS 994
P+ + L+ E + +G + S S SL++T + E+ + +S
Sbjct: 958 PKAGNSRASLEAGEELRGSTRLRGSGPLL---SDSGSLLATGSARVGTPGPPEDGDSLYS 1014
Query: 995 ---QLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNRE 1051
QL T LY+A+W GALAVS + +V S ++G + + F HHC R
Sbjct: 1015 PGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRR 1074
Query: 1052 DVRLAWIMTCCPGRSSYSVQVNVQPP--------NSNGTNGEAPKCPNSSAESSCTNKSA 1103
DVR +W CCP S + PP + + GE P SS S + A
Sbjct: 1075 DVRASW-RACCPPASPAAPHA---PPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLA 1130
Query: 1104 SSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHSMDNDIKMHVAPLEVQFR 1163
CKLTNLQ A +Q + + + T ++ H P V
Sbjct: 1131 LG------PCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNL-----AHRHPNNVH-- 1177
Query: 1164 TNVHSSRHHKNRSKGHRA------SRLTVLR---EYAYDVPTSVEGSVQNGLPKSRLGNN 1214
H R HK+R+KGHRA +RL LR A ++ +S GS+ N S LG++
Sbjct: 1178 ---HGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSS 1234
Query: 1215 EGHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNFEKPVSTTSKKDALRKPAVVEL 1274
S A L P + S + + L ++ R ++ ++ +D+L+ +E
Sbjct: 1235 R---NSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQR---RSASRDSLKGGGALEK 1288
Query: 1275 ENQQKSYGLNLAIQNGPIKSNGQEG-PLLGTD--STGNVRTGLWKHETTV 1321
E+ ++SY LN A NG K + L+G + S G ++TGLWK ETTV
Sbjct: 1289 ESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV 1338
>gi|144922665 G protein-coupled receptor 123 [Homo sapiens]
Length = 560
Score = 414 bits (1064), Expect = e-115
Identities = 249/586 (42%), Positives = 328/586 (55%), Gaps = 34/586 (5%)
Query: 744 MDL-TGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLC 802
MDL T L LHPVVY ++LLCLLA V+YI H S IRIS K H L+N C
Sbjct: 1 MDLKTVLSLPRYPGEFLHPVVYACTAVMLLCLLASFVTYIVHQSAIRISRKGRHTLLNFC 60
Query: 803 FHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQ 862
FH LT VF GGI +T+ +CQAVGI+LHYSTL+T+LW+GVTARNIYKQVTKKA C
Sbjct: 61 FHAALTFTVFAGGINRTKYPILCQAVGIVLHYSTLSTMLWIGVTARNIYKQVTKKAPLCL 120
Query: 863 DPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSR-PNAPYCWMAWEPSLGAFY 921
D D+PP P +P+LRFYL+ GG+P I+CG+TAA NI+NYG+ + YCWMAWEPSLGAFY
Sbjct: 121 DTDQPPYPRQPLLRFYLVSGGVPFIICGVTAATNIRNYGTEDEDTAYCWMAWEPSLGAFY 180
Query: 922 GPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGE-INHQDSMSLSL 980
GPA+ IT V C+YFL ++QL+RHP R+YEL+ EEQ+RLA E G I +
Sbjct: 181 GPAAIITLVTCVYFLGTYVQLRRHPGRRYELRTQPEEQRRLATPEGGRGIRPGTPPAHDA 240
Query: 981 ISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFSA 1040
S L+NEH+F +QL A+ TL L+ A W FGALAVS + LD+VFS ++GA ++
Sbjct: 241 PGASVLQNEHSFQAQLRAAAFTLFLFTATWAFGALAVSQGHFLDMVFSCLYGAFCVTLGL 300
Query: 1041 FFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAESSCTN 1100
F ++HHC REDV W CCP R + ++NG C +S
Sbjct: 301 FVLIHHCAKREDVWQCW-WACCPPRKDAHPAL-----DANGAALGRAACLHSPGLG---- 350
Query: 1101 KSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHSMDNDIKMHVAPLEV 1160
F + CK+TNLQ AAQ HA+ L +TP E ++ +H+ E
Sbjct: 351 -QPRGFAHPPGPCKMTNLQ--AAQGHASCLS-PATPCCAKMHCEPLTADEAHVHLQE-EG 405
Query: 1161 QFRTNVHSSRHHKNRSKGHRASRLTVLR-EYAYDVPTSVEGSVQNGLPKSRLGNNEGHSR 1219
F + H + R+K SR EYAY +P+S++GS ++ S + +G +
Sbjct: 406 AFGHDPHLHGCLQGRTKPPYFSRHPAEEPEYAYHIPSSLDGSPRSSRTDSPPSSLDGPAG 465
Query: 1220 SRRAYLAYRERQY----NPPQQDSSDACSTLPKSSRNFEKPVSTTSKKDALRKPAVVELE 1275
+ + + P D S A + P T ++A P +E+
Sbjct: 466 THTLACCTQGDPFPMVTQPEGSDGSPALYSCP-----------TQPGREAALGPGHLEML 514
Query: 1276 NQQKSYGLNLAIQNGPIKSNGQEGPLLGTDSTGNVRTGLWKHETTV 1321
+ +S QNG K EG GTD TGN+RTG WK+ETTV
Sbjct: 515 RRTQSLPFGGPSQNGLPKGKLLEGLPFGTDGTGNIRTGPWKNETTV 560
>gi|59710093 G-protein coupled receptor 112 [Homo sapiens]
Length = 3080
Score = 125 bits (313), Expect = 3e-28
Identities = 120/459 (26%), Positives = 193/459 (42%), Gaps = 73/459 (15%)
Query: 616 SLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKI- 674
S++ PK E P L LQ I LF G ++ + + T V+ I
Sbjct: 2606 SIYLPKSLTERIP----LSNLQTI------LFNFFGQTSLFKTKNVTKALTTYVVSASIS 2655
Query: 675 DGVNVDTHHIPVNVTLRRIAHGAD---AVAARWDFDLLNGQGGWKSDGCHILYSDENITT 731
D + + PV +TL+ I + A WDF+ NG GGW S GC + ++ N T
Sbjct: 2656 DDMFIQNLADPVVITLQHIGGNQNYGQVHCAFWDFENNNGLGGWNSSGCKVKETNVNYTI 2715
Query: 732 IQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRIS 791
QC L+++ VLMDL+ S + + +L + YT I + L +V+YI H L +
Sbjct: 2716 CQCDHLTHFGVLMDLSRSTVDSVNEQILALITYTGCGISSIFLGVAVVTYIAFHKLRKDY 2775
Query: 792 LKSWHMLVNLCFHIFLTCVVFV--GGITQTRNASICQAVGIILHYSTLATVLWVGVTARN 849
+L+NLC + + +VF+ ++ + +C + LHY L + W+G+ A +
Sbjct: 2776 PAK--ILINLCTALLMLNLVFLINSWLSSFQKVGVCITAAVALHYFLLVSFTWMGLEAVH 2833
Query: 850 IYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGS-RPNAPY 908
+Y + K P +L+F L+G GIP I+ IT + YG+ P P+
Sbjct: 2834 MYLALVKVFNIY--------IPNYILKFCLVGWGIPAIMVAITVSVKKDLYGTLSPTTPF 2885
Query: 909 CWMAWEP----SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAA 964
CW+ + S+ A++ I +N F ++ +QL +K ++ +R
Sbjct: 2886 CWIKDDSIFYISVVAYF---CLIFLMNLSMFCTVLVQLN-------SVKSQIQKTRR--- 2932
Query: 965 NENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLD 1024
+ H SLT LL + W F A + P+
Sbjct: 2933 ------------------------KMILHDLKGTMSLTFLLGLT-WGFAFFA---WGPMR 2964
Query: 1025 LVFSFVFGATSLSFSAFFVVHHCVNREDVRLAW-IMTCC 1062
F ++F + F V HCV +E VR W I CC
Sbjct: 2965 NFFLYLFAIFNTLQGFFIFVFHCVMKESVREQWQIHLCC 3003
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 120 bits (301), Expect = 9e-27
Identities = 112/447 (25%), Positives = 195/447 (43%), Gaps = 69/447 (15%)
Query: 619 SPKQKRELRPTDDSLYKLQLIAFRN--GKLFPATGNSTNLADDGKRRTVV-TPVILTKI- 674
+P +R P D + + L+ G+L P + + R ++ TP++ T +
Sbjct: 2321 APISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVY 2380
Query: 675 -DGVNVDT---HHIPVNVTLRRIAHGADAVAARWDFDL-LNGQGGWKSDGCHILYSDENI 729
+G + + V L + V W+ L + G GGW + GC +L +
Sbjct: 2381 SEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTH 2440
Query: 730 TTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIR 789
QC +++AVLMD++ E + P+ T + L L A++V+++ SL+R
Sbjct: 2441 VACQCSHTASFAVLMDISRRE-----NGEVLPLKIVTYAAVSLSLAALLVAFVLL-SLVR 2494
Query: 790 ISLKSWHML-VNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTAR 848
+ + H + +L +FL+ +VFV GI QT N +C V I+LHY ++T W V +
Sbjct: 2495 MLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILLHYIYMSTFAWTLVESL 2554
Query: 849 NIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPY 908
++Y+ +T+ PM +Y++G GIP IV G+ + + YG N +
Sbjct: 2555 HVYRMLTEVRN---------IDTGPMRFYYVVGWGIPAIVTGLAVGLDPQGYG---NPDF 2602
Query: 909 CWMAWEPSL-GAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANEN 967
CW++ + +L +F GP + +N ++ + K +RK+
Sbjct: 2603 CWLSLQDTLIWSFAGPIGAVIIINT---VTSVLSAKVSCQRKHHY--------------- 2644
Query: 968 GEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVF 1027
+ +SL+ T A L LLL A W+ G LAV+ L F
Sbjct: 2645 ----YGKKGIVSLLRT---------------AFLLLLLISATWLLGLLAVNRD---ALSF 2682
Query: 1028 SFVFGATSLSFSAFFVVHHCVNREDVR 1054
++F S F ++ HCV ++VR
Sbjct: 2683 HYLFAIFSGLQGPFVLLFHCVLNQEVR 2709
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 118 bits (295), Expect = 4e-26
Identities = 79/254 (31%), Positives = 121/254 (47%), Gaps = 7/254 (2%)
Query: 85 TLILSNNKISELKNGSFSGLSLLERLDLRNNLIS-SIDP--GAFWGLSSLKRLDLTNNRI 141
TL + NN++S + + +F GLS L+ LDL+NN IS +I+ GAF GL L+RL L NRI
Sbjct: 339 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 398
Query: 142 GCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRW 201
+ F GL L L+LS N SL F + L+ L T LLCDC + W+ +W
Sbjct: 399 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 458
Query: 202 VKEKNI-TVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSL 260
V E N + + C +P+ L+ + + V + CD P + P Q +G +L
Sbjct: 459 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCD-DFPKPQITVQP-ETQSAIKGSNL 516
Query: 261 PFQC-MASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGST 319
F C AS D M W +D ++ E + + + L + ++ S
Sbjct: 517 SFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASE 576
Query: 320 GNWGCHVQTKRGNN 333
G + C + G++
Sbjct: 577 GKYQCVISNHFGSS 590
Score = 58.2 bits (139), Expect = 5e-08
Identities = 32/104 (30%), Positives = 55/104 (52%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L+ NKI + +F GL L+ L ++ N ++ + GAFWGLS+++ L L +N + +
Sbjct: 220 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 279
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYL 189
GL L L+LS N + +S +++ L L+ +L
Sbjct: 280 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHL 323
Score = 56.6 bits (135), Expect = 2e-07
Identities = 34/100 (34%), Positives = 54/100 (54%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L +N ++E+ G GL +L+ L L N I+ I P A+ L LDLT N + L+
Sbjct: 268 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 327
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQ 185
F GL+ L L++ N S ++ F L+SL++L+ +
Sbjct: 328 DSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLK 367
Score = 52.0 bits (123), Expect = 4e-06
Identities = 34/111 (30%), Positives = 58/111 (52%), Gaps = 2/111 (1%)
Query: 85 TLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
+L + N +++L +G+F GLS +E L L +N ++ I G +GL L+ L L+ N I +
Sbjct: 243 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRI 302
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYL--LCDC 193
+ D + L L+L+ N S L +F L+ L +L + + DC
Sbjct: 303 SPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 353
Score = 46.2 bits (108), Expect = 2e-04
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 8/154 (5%)
Query: 17 LPLSLLALLALLGGGGGGGAAAL--PAGCKHDGRPRGAGRAAGAAEGKVVCSSLELAQVL 74
L L L A+L G GG L P+G + R G + CS LA++
Sbjct: 13 LGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDL---LDCSRKRLARL- 68
Query: 75 PPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRL 134
P+ LP+ L LS+N++S +K S S L L + L NN + +I P +++ L
Sbjct: 69 -PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLL 126
Query: 135 DLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSL 168
L NRI + + + +L L+LS N S L
Sbjct: 127 SLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160
Score = 44.3 bits (103), Expect = 8e-04
Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 2/99 (2%)
Query: 86 LILSNNKISELKNGSFSGLS-LLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
L L++N+++ ++ G F L+ L L L N IS+I P F L L+ L+L N+I +
Sbjct: 172 LYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNV 230
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLE 183
+ F+GL L L + N + L G F L+++ L+
Sbjct: 231 DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 269
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 118 bits (295), Expect = 4e-26
Identities = 79/254 (31%), Positives = 121/254 (47%), Gaps = 7/254 (2%)
Query: 85 TLILSNNKISELKNGSFSGLSLLERLDLRNNLIS-SIDP--GAFWGLSSLKRLDLTNNRI 141
TL + NN++S + + +F GLS L+ LDL+NN IS +I+ GAF GL L+RL L NRI
Sbjct: 279 TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRI 338
Query: 142 GCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRW 201
+ F GL L L+LS N SL F + L+ L T LLCDC + W+ +W
Sbjct: 339 RSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQW 398
Query: 202 VKEKNI-TVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSL 260
V E N + + C +P+ L+ + + V + CD P + P Q +G +L
Sbjct: 399 VAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCD-DFPKPQITVQP-ETQSAIKGSNL 456
Query: 261 PFQC-MASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGST 319
F C AS D M W +D ++ E + + + L + ++ S
Sbjct: 457 SFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASE 516
Query: 320 GNWGCHVQTKRGNN 333
G + C + G++
Sbjct: 517 GKYQCVISNHFGSS 530
Score = 58.2 bits (139), Expect = 5e-08
Identities = 32/104 (30%), Positives = 55/104 (52%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L+ NKI + +F GL L+ L ++ N ++ + GAFWGLS+++ L L +N + +
Sbjct: 160 LELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEIT 219
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYL 189
GL L L+LS N + +S +++ L L+ +L
Sbjct: 220 KGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHL 263
Score = 56.6 bits (135), Expect = 2e-07
Identities = 34/100 (34%), Positives = 54/100 (54%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L +N ++E+ G GL +L+ L L N I+ I P A+ L LDLT N + L+
Sbjct: 208 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 267
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQ 185
F GL+ L L++ N S ++ F L+SL++L+ +
Sbjct: 268 DSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLK 307
Score = 52.0 bits (123), Expect = 4e-06
Identities = 34/111 (30%), Positives = 58/111 (52%), Gaps = 2/111 (1%)
Query: 85 TLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
+L + N +++L +G+F GLS +E L L +N ++ I G +GL L+ L L+ N I +
Sbjct: 183 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRI 242
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYL--LCDC 193
+ D + L L+L+ N S L +F L+ L +L + + DC
Sbjct: 243 SPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293
Score = 44.3 bits (103), Expect = 8e-04
Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 2/99 (2%)
Query: 86 LILSNNKISELKNGSFSGLS-LLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
L L++N+++ ++ G F L+ L L L N IS+I P F L L+ L+L N+I +
Sbjct: 112 LYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNV 170
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLE 183
+ F+GL L L + N + L G F L+++ L+
Sbjct: 171 DGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 209
Score = 40.4 bits (93), Expect = 0.011
Identities = 41/138 (29%), Positives = 62/138 (44%), Gaps = 30/138 (21%)
Query: 77 DTLPN-----RTVTLI-LSNNKISELKNGSFSGLSLLERLDLRNNLIS------------ 118
+T+PN +TL+ L+ N+I E+ LE LDL +N IS
Sbjct: 51 ETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLK 110
Query: 119 ----------SIDPGAFWGL-SSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSS 167
S++PG F L ++L L L NRI + +F+ L L L L+ N +
Sbjct: 111 YLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKN 169
Query: 168 LSQGTFDYLASLRSLEFQ 185
+ TF L +L+SL+ Q
Sbjct: 170 VDGLTFQGLGALKSLKMQ 187
Score = 34.7 bits (78), Expect = 0.62
Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Query: 88 LSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNAD 147
LS+N++S +K S S L L + L NN + +I P +++ L L NRI + +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPE 79
Query: 148 IFRGLTNLVRLNLSGNLFSSL 168
+ +L L+LS N S L
Sbjct: 80 HLKEFQSLETLDLSSNNISEL 100
>gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo
sapiens]
Length = 1250
Score = 114 bits (285), Expect = 6e-25
Identities = 180/805 (22%), Positives = 313/805 (38%), Gaps = 148/805 (18%)
Query: 401 DRGGFWADDDYSRCQYANDVTRVLYMFNQMPLN--LTNAVATARQLLAYTVEAANFSDKM 458
D+ GF A SR + N ++ + + ++ L A A Q+L T + N +
Sbjct: 550 DKPGFSA----SRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSAN 605
Query: 459 DVIFVAEMIEKFGRFTKEEKSKE--LGDVMVDIASNIMLADERVLWLAQREAKACSRIVQ 516
+ ++E+ R +E++ + LG +++I SNI+ + + L + EA
Sbjct: 606 ----ITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEA-------- 653
Query: 517 CLQRIATYRLAGGAHVYSTYSPNIALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGR 576
L+ I LA + ST NI + + T +S++
Sbjct: 654 -LKTID--ELAFKIDLNSTSHVNITTRNLALSVSSLLPGT------------NAISNFSI 698
Query: 577 RDPEGNLDK-QLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYK 635
P N Q+ F+ + AS+ LPP+L L P D L +
Sbjct: 699 GLPSNNESYFQMDFESGQVDPL-----------ASVILPPNLLE-----NLSPEDSVLVR 742
Query: 636 -LQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLR--R 692
Q F LF G +R+T+V+ V+ I + + PV + ++ R
Sbjct: 743 RAQFTFFNKTGLFQDVGP--------QRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTR 794
Query: 693 IAHGADAVAARWDFDLLNGQGGWKSDGCHILY-SDENITTIQCYSLSNYAVLMDL--TGS 749
+ A WD + GGW + GC SD + T C +++ VLMDL + S
Sbjct: 795 TQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSAS 854
Query: 750 ELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTC 809
+L + +L + Y I + A +++Y+ L R +L+NL +
Sbjct: 855 QLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSK--ILMNLSTALLFLN 912
Query: 810 VVFV--GGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEP 867
++F+ G IT +C AV ++LH+ LAT W+G+ A ++Y + K
Sbjct: 913 LLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTY------ 966
Query: 868 PPPPRPMLRFYLIGGGIPIIVCGITAAANIKN-------YGSRPNAPYCWMAWEPSLGAF 920
R +L+F +IG G+P +V + A+ N YG +CW+ +P + F
Sbjct: 967 --IRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQ-DPVI--F 1021
Query: 921 Y----GPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSM 976
Y G + F+N F+ + +Q+ NG+ +++
Sbjct: 1022 YVTCAGYFGVMFFLNIAMFIVVMVQI---------------------CGRNGKRSNR--- 1057
Query: 977 SLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSL 1036
+ L N + SLT LL + W F A + PL++ F ++F +
Sbjct: 1058 ---TLREEVLRNLRSV------VSLTFLLGMT-WGFAFFA---WGPLNIPFMYLFSIFNS 1104
Query: 1037 SFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAES 1096
F + HC +E+V+ W C GR + N + K + +
Sbjct: 1105 LQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLA------------DNSDWSKTATNIIKK 1152
Query: 1097 SCTN--KSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHS-MDND--- 1150
S N KS SS S LT+ +++ + + +D SL++ + D D
Sbjct: 1153 SSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDSASMDKSLSKLAHADGDQTS 1212
Query: 1151 -IKMHVAPLEVQFRTNVHSSRHHKN 1174
I +H +V+ N HS +KN
Sbjct: 1213 IIPVHQVIDKVKGYCNAHSDNFYKN 1237
>gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo
sapiens]
Length = 1222
Score = 114 bits (285), Expect = 6e-25
Identities = 180/805 (22%), Positives = 313/805 (38%), Gaps = 148/805 (18%)
Query: 401 DRGGFWADDDYSRCQYANDVTRVLYMFNQMPLN--LTNAVATARQLLAYTVEAANFSDKM 458
D+ GF A SR + N ++ + + ++ L A A Q+L T + N +
Sbjct: 522 DKPGFSA----SRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSAN 577
Query: 459 DVIFVAEMIEKFGRFTKEEKSKE--LGDVMVDIASNIMLADERVLWLAQREAKACSRIVQ 516
+ ++E+ R +E++ + LG +++I SNI+ + + L + EA
Sbjct: 578 ----ITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEA-------- 625
Query: 517 CLQRIATYRLAGGAHVYSTYSPNIALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGR 576
L+ I LA + ST NI + + T +S++
Sbjct: 626 -LKTID--ELAFKIDLNSTSHVNITTRNLALSVSSLLPGT------------NAISNFSI 670
Query: 577 RDPEGNLDK-QLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYK 635
P N Q+ F+ + AS+ LPP+L L P D L +
Sbjct: 671 GLPSNNESYFQMDFESGQVDPL-----------ASVILPPNLLE-----NLSPEDSVLVR 714
Query: 636 -LQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLR--R 692
Q F LF G +R+T+V+ V+ I + + PV + ++ R
Sbjct: 715 RAQFTFFNKTGLFQDVGP--------QRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTR 766
Query: 693 IAHGADAVAARWDFDLLNGQGGWKSDGCHILY-SDENITTIQCYSLSNYAVLMDL--TGS 749
+ A WD + GGW + GC SD + T C +++ VLMDL + S
Sbjct: 767 TQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSAS 826
Query: 750 ELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTC 809
+L + +L + Y I + A +++Y+ L R +L+NL +
Sbjct: 827 QLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSK--ILMNLSTALLFLN 884
Query: 810 VVFV--GGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEP 867
++F+ G IT +C AV ++LH+ LAT W+G+ A ++Y + K
Sbjct: 885 LLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTY------ 938
Query: 868 PPPPRPMLRFYLIGGGIPIIVCGITAAANIKN-------YGSRPNAPYCWMAWEPSLGAF 920
R +L+F +IG G+P +V + A+ N YG +CW+ +P + F
Sbjct: 939 --IRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQ-DPVI--F 993
Query: 921 Y----GPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSM 976
Y G + F+N F+ + +Q+ NG+ +++
Sbjct: 994 YVTCAGYFGVMFFLNIAMFIVVMVQI---------------------CGRNGKRSNR--- 1029
Query: 977 SLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSL 1036
+ L N + SLT LL + W F A + PL++ F ++F +
Sbjct: 1030 ---TLREEVLRNLRSV------VSLTFLLGMT-WGFAFFA---WGPLNIPFMYLFSIFNS 1076
Query: 1037 SFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAES 1096
F + HC +E+V+ W C GR + N + K + +
Sbjct: 1077 LQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLA------------DNSDWSKTATNIIKK 1124
Query: 1097 SCTN--KSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHS-MDND--- 1150
S N KS SS S LT+ +++ + + +D SL++ + D D
Sbjct: 1125 SSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDSASMDKSLSKLAHADGDQTS 1184
Query: 1151 -IKMHVAPLEVQFRTNVHSSRHHKN 1174
I +H +V+ N HS +KN
Sbjct: 1185 IIPVHQVIDKVKGYCNAHSDNFYKN 1209
>gi|45433552 G protein-coupled receptor 133 [Homo sapiens]
Length = 874
Score = 110 bits (275), Expect = 9e-24
Identities = 98/450 (21%), Positives = 191/450 (42%), Gaps = 67/450 (14%)
Query: 668 PVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAARWDF----DLLNGQGGWKSDGCHIL 723
P + + G + T H+ +T ++ + ++ + + D +G+G W + GC +
Sbjct: 471 PTLSQNLSGSPLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALT 530
Query: 724 YSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIY 783
+ + +C L+N+A+LM + EL L + Y + +LCL+A +V++
Sbjct: 531 RGNLTYSVCRCTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAV 590
Query: 784 HHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWV 843
S+ I + +H+ NL F + + V+ + + CQ + ++LHY L+ W+
Sbjct: 591 LSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWM 650
Query: 844 GVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSR 903
V ++Y V K +D +Y +G G P+++C I+ + + +YG+
Sbjct: 651 LVEGLHLYSMVI-KVFGSEDSKH--------RYYYGMGWGFPLLICIISLSFAMDSYGTS 701
Query: 904 PNAPYCWMAW-EPSLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRL 962
N CW++ ++ AF PA F+ VN +++ + + Y++
Sbjct: 702 NN---CWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKI---------- 748
Query: 963 AANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYP 1022
H D + L + + ++ L + W+FG LAV+
Sbjct: 749 ---------HGDPSAFKLTAKA--------------VAVLLPILGTSWVFGVLAVN---G 782
Query: 1023 LDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLA-------WIMTCCPGRSSYSVQVNVQ 1075
+VF ++F + F + HC+ +VR A W +T R+S N +
Sbjct: 783 CAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTS-----NAK 837
Query: 1076 PPNSNGTNGEAPKCPNSSAESSCTNKSASS 1105
P +S+ NG P +S + S +KS+ S
Sbjct: 838 PFHSDLMNGTRPGM--ASTKLSPWDKSSHS 865
>gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]
Length = 995
Score = 110 bits (275), Expect = 9e-24
Identities = 123/539 (22%), Positives = 216/539 (40%), Gaps = 74/539 (13%)
Query: 664 TVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAAR---WDFDLLNGQGGWKSDGC 720
++++ VI + + + V V VTL+ I D + R WD G+GGW +GC
Sbjct: 508 SLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNGC 567
Query: 721 HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS 780
+ N T C L+++ VL+DL+ + + L + Y + + L +V+
Sbjct: 568 SVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVT 627
Query: 781 YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFV--GGITQTRNASICQAVGIILHYSTLA 838
YI + R +L+ LC + L +VF+ I + +C +V + LHY L
Sbjct: 628 YIAFEKIRRDYPSK--ILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLV 685
Query: 839 TVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIK 898
+ W+G+ A ++Y + K + +L+F ++G G+P +V I +
Sbjct: 686 SFTWMGLEAFHMYLALVKVFNTYIR--------KYILKFCIVGWGVPAVVVTIILTISPD 737
Query: 899 NYG-----SRPNAPYCWMAWEPSLGAFY----GPASFITFVNCMYFLSIFIQLKRHPERK 949
NYG PN W + FY G I +N F+ + +QL R ++K
Sbjct: 738 NYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKK 797
Query: 950 YELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVAL 1009
+L A I QD S+ A LT LL +
Sbjct: 798 -----------QLGAQRKTSI--QDLRSI--------------------AGLTFLLGIT- 823
Query: 1010 WMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYS 1069
W F A + P+++ F ++F + F + +CV +E+VR W C G+ +
Sbjct: 824 WGFAFFA---WGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLA 880
Query: 1070 VQVNVQPPNSNGTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANS 1129
+ + TNG + N SS + +SS +S + N + A + N+
Sbjct: 881 ENSDW---SKTATNGLKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNA 937
Query: 1130 LPLNSTPQLDNSLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLR 1188
ST + N ++ + D+ +H + + ++ + + KG A R T R
Sbjct: 938 ----STER--NGVSFSVQNGDVCLH----DFTGKQHMFNEKEDSCNGKGRMALRRTSKR 986
>gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]
Length = 1003
Score = 110 bits (275), Expect = 9e-24
Identities = 123/539 (22%), Positives = 216/539 (40%), Gaps = 74/539 (13%)
Query: 664 TVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAAR---WDFDLLNGQGGWKSDGC 720
++++ VI + + + V V VTL+ I D + R WD G+GGW +GC
Sbjct: 516 SLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNGC 575
Query: 721 HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS 780
+ N T C L+++ VL+DL+ + + L + Y + + L +V+
Sbjct: 576 SVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVT 635
Query: 781 YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFV--GGITQTRNASICQAVGIILHYSTLA 838
YI + R +L+ LC + L +VF+ I + +C +V + LHY L
Sbjct: 636 YIAFEKIRRDYPSK--ILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLV 693
Query: 839 TVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIK 898
+ W+G+ A ++Y + K + +L+F ++G G+P +V I +
Sbjct: 694 SFTWMGLEAFHMYLALVKVFNTYIR--------KYILKFCIVGWGVPAVVVTIILTISPD 745
Query: 899 NYG-----SRPNAPYCWMAWEPSLGAFY----GPASFITFVNCMYFLSIFIQLKRHPERK 949
NYG PN W + FY G I +N F+ + +QL R ++K
Sbjct: 746 NYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKK 805
Query: 950 YELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVAL 1009
+L A I QD S+ A LT LL +
Sbjct: 806 -----------QLGAQRKTSI--QDLRSI--------------------AGLTFLLGIT- 831
Query: 1010 WMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYS 1069
W F A + P+++ F ++F + F + +CV +E+VR W C G+ +
Sbjct: 832 WGFAFFA---WGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLA 888
Query: 1070 VQVNVQPPNSNGTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANS 1129
+ + TNG + N SS + +SS +S + N + A + N+
Sbjct: 889 ENSDW---SKTATNGLKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNA 945
Query: 1130 LPLNSTPQLDNSLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLR 1188
ST + N ++ + D+ +H + + ++ + + KG A R T R
Sbjct: 946 ----STER--NGVSFSVQNGDVCLH----DFTGKQHMFNEKEDSCNGKGRMALRRTSKR 994
>gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]
Length = 1017
Score = 110 bits (275), Expect = 9e-24
Identities = 123/539 (22%), Positives = 216/539 (40%), Gaps = 74/539 (13%)
Query: 664 TVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAAR---WDFDLLNGQGGWKSDGC 720
++++ VI + + + V V VTL+ I D + R WD G+GGW +GC
Sbjct: 530 SLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNGC 589
Query: 721 HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS 780
+ N T C L+++ VL+DL+ + + L + Y + + L +V+
Sbjct: 590 SVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVT 649
Query: 781 YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFV--GGITQTRNASICQAVGIILHYSTLA 838
YI + R +L+ LC + L +VF+ I + +C +V + LHY L
Sbjct: 650 YIAFEKIRRDYPSK--ILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLV 707
Query: 839 TVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIK 898
+ W+G+ A ++Y + K + +L+F ++G G+P +V I +
Sbjct: 708 SFTWMGLEAFHMYLALVKVFNTYIR--------KYILKFCIVGWGVPAVVVTIILTISPD 759
Query: 899 NYG-----SRPNAPYCWMAWEPSLGAFY----GPASFITFVNCMYFLSIFIQLKRHPERK 949
NYG PN W + FY G I +N F+ + +QL R ++K
Sbjct: 760 NYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKK 819
Query: 950 YELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVAL 1009
+L A I QD S+ A LT LL +
Sbjct: 820 -----------QLGAQRKTSI--QDLRSI--------------------AGLTFLLGIT- 845
Query: 1010 WMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYS 1069
W F A + P+++ F ++F + F + +CV +E+VR W C G+ +
Sbjct: 846 WGFAFFA---WGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLA 902
Query: 1070 VQVNVQPPNSNGTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANS 1129
+ + TNG + N SS + +SS +S + N + A + N+
Sbjct: 903 ENSDW---SKTATNGLKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNA 959
Query: 1130 LPLNSTPQLDNSLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLR 1188
ST + N ++ + D+ +H + + ++ + + KG A R T R
Sbjct: 960 ----STER--NGVSFSVQNGDVCLH----DFTGKQHMFNEKEDSCNGKGRMALRRTSKR 1008
>gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]
Length = 1014
Score = 110 bits (275), Expect = 9e-24
Identities = 123/539 (22%), Positives = 216/539 (40%), Gaps = 74/539 (13%)
Query: 664 TVVTPVILTKIDGVNVDTHHIPVNVTLRRIAHGADAVAAR---WDFDLLNGQGGWKSDGC 720
++++ VI + + + V V VTL+ I D + R WD G+GGW +GC
Sbjct: 527 SLISYVISSSVANLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNGC 586
Query: 721 HILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVS 780
+ N T C L+++ VL+DL+ + + L + Y + + L +V+
Sbjct: 587 SVKDRRLNETICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVT 646
Query: 781 YIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFV--GGITQTRNASICQAVGIILHYSTLA 838
YI + R +L+ LC + L +VF+ I + +C +V + LHY L
Sbjct: 647 YIAFEKIRRDYPSK--ILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLV 704
Query: 839 TVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIK 898
+ W+G+ A ++Y + K + +L+F ++G G+P +V I +
Sbjct: 705 SFTWMGLEAFHMYLALVKVFNTYIR--------KYILKFCIVGWGVPAVVVTIILTISPD 756
Query: 899 NYG-----SRPNAPYCWMAWEPSLGAFY----GPASFITFVNCMYFLSIFIQLKRHPERK 949
NYG PN W + FY G I +N F+ + +QL R ++K
Sbjct: 757 NYGLGSYGKFPNGSPDDFCWINNNAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIKKKK 816
Query: 950 YELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLLLYVAL 1009
+L A I QD S+ A LT LL +
Sbjct: 817 -----------QLGAQRKTSI--QDLRSI--------------------AGLTFLLGIT- 842
Query: 1010 WMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYS 1069
W F A + P+++ F ++F + F + +CV +E+VR W C G+ +
Sbjct: 843 WGFAFFA---WGPVNVTFMYLFAIFNTLQGFFIFIFYCVAKENVRKQWRRYLCCGKLRLA 899
Query: 1070 VQVNVQPPNSNGTNGEAPKCPNSSAESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANS 1129
+ + TNG + N SS + +SS +S + N + A + N+
Sbjct: 900 ENSDW---SKTATNGLKKQTVNQGVSSSSNSLQSSSNSTNSTTLLVNNDCSVHASGNGNA 956
Query: 1130 LPLNSTPQLDNSLTEHSMDNDIKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLR 1188
ST + N ++ + D+ +H + + ++ + + KG A R T R
Sbjct: 957 ----STER--NGVSFSVQNGDVCLH----DFTGKQHMFNEKEDSCNGKGRMALRRTSKR 1005
>gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Homo
sapiens]
Length = 1221
Score = 108 bits (271), Expect = 3e-23
Identities = 173/772 (22%), Positives = 296/772 (38%), Gaps = 144/772 (18%)
Query: 401 DRGGFWADDDYSRCQYANDVTRVLYMFNQMPLN--LTNAVATARQLLAYTVEAANFSDKM 458
D+ GF A SR + N ++ + + ++ L A A Q+L T + N +
Sbjct: 550 DKPGFSA----SRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSAN 605
Query: 459 DVIFVAEMIEKFGRFTKEEKSKE--LGDVMVDIASNIMLADERVLWLAQREAKACSRIVQ 516
+ ++E+ R +E++ + LG +++I SNI+ + + L + EA
Sbjct: 606 ----ITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEA-------- 653
Query: 517 CLQRIATYRLAGGAHVYSTYSPNIALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGR 576
L+ I LA + ST NI + + T +S++
Sbjct: 654 -LKTID--ELAFKIDLNSTSHVNITTRNLALSVSSLLPGT------------NAISNFSI 698
Query: 577 RDPEGNLDK-QLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYK 635
P N Q+ F+ + AS+ LPP+L L P D L +
Sbjct: 699 GLPSNNESYFQMDFESGQVDPL-----------ASVILPPNLLE-----NLSPEDSVLVR 742
Query: 636 -LQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLR--R 692
Q F LF G +R+T+V+ V+ I + + PV + ++ R
Sbjct: 743 RAQFTFFNKTGLFQDVGP--------QRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTR 794
Query: 693 IAHGADAVAARWDFDLLNGQGGWKSDGCHILY-SDENITTIQCYSLSNYAVLMDL--TGS 749
+ A WD + GGW + GC SD + T C +++ VLMDL + S
Sbjct: 795 TQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSAS 854
Query: 750 ELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTC 809
+L + +L + Y I + A +++Y+ L R +L+NL +
Sbjct: 855 QLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSK--ILMNLSTALLFLN 912
Query: 810 VVFV--GGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEP 867
++F+ G IT +C AV ++LH+ LAT W+G+ A ++Y + K
Sbjct: 913 LLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTY------ 966
Query: 868 PPPPRPMLRFYLIGGGIPIIVCGITAAANIKN-------YGSRPNAPYCWMAWEPSLGAF 920
R +L+F +IG G+P +V + A+ N YG +CW+ +P + F
Sbjct: 967 --IRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQ-DPVI--F 1021
Query: 921 Y----GPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSM 976
Y G + F+N F+ + +Q+ NG+ +++
Sbjct: 1022 YVTCAGYFGVMFFLNIAMFIVVMVQI---------------------CGRNGKRSNR--- 1057
Query: 977 SLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSL 1036
+ L N + SLT LL + W F A + PL++ F ++F +
Sbjct: 1058 ---TLREEVLRNLRSV------VSLTFLLGMT-WGFAFFA---WGPLNIPFMYLFSIFNS 1104
Query: 1037 SFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAES 1096
F + HC +E+V+ W C GR + N + K + +
Sbjct: 1105 LQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLA------------DNSDWSKTATNIIKK 1152
Query: 1097 SCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHSMD 1148
S N S +SS G T L + + NS DN EHS +
Sbjct: 1153 SSDN-LGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNS--HTDNVSYEHSFN 1201
>gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Homo
sapiens]
Length = 1193
Score = 108 bits (271), Expect = 3e-23
Identities = 173/772 (22%), Positives = 296/772 (38%), Gaps = 144/772 (18%)
Query: 401 DRGGFWADDDYSRCQYANDVTRVLYMFNQMPLN--LTNAVATARQLLAYTVEAANFSDKM 458
D+ GF A SR + N ++ + + ++ L A A Q+L T + N +
Sbjct: 522 DKPGFSA----SRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSAN 577
Query: 459 DVIFVAEMIEKFGRFTKEEKSKE--LGDVMVDIASNIMLADERVLWLAQREAKACSRIVQ 516
+ ++E+ R +E++ + LG +++I SNI+ + + L + EA
Sbjct: 578 ----ITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEA-------- 625
Query: 517 CLQRIATYRLAGGAHVYSTYSPNIALEAYVIKSTGFTGMTCTVFQKVAASDRTGLSDYGR 576
L+ I LA + ST NI + + T +S++
Sbjct: 626 -LKTID--ELAFKIDLNSTSHVNITTRNLALSVSSLLPGT------------NAISNFSI 670
Query: 577 RDPEGNLDK-QLSFKCNVSNTFSSLALKNTIVEASIQLPPSLFSPKQKRELRPTDDSLYK 635
P N Q+ F+ + AS+ LPP+L L P D L +
Sbjct: 671 GLPSNNESYFQMDFESGQVDPL-----------ASVILPPNLLE-----NLSPEDSVLVR 714
Query: 636 -LQLIAFRNGKLFPATGNSTNLADDGKRRTVVTPVILTKIDGVNVDTHHIPVNVTLR--R 692
Q F LF G +R+T+V+ V+ I + + PV + ++ R
Sbjct: 715 RAQFTFFNKTGLFQDVGP--------QRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTR 766
Query: 693 IAHGADAVAARWDFDLLNGQGGWKSDGCHILY-SDENITTIQCYSLSNYAVLMDL--TGS 749
+ A WD + GGW + GC SD + T C +++ VLMDL + S
Sbjct: 767 TQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSAS 826
Query: 750 ELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTC 809
+L + +L + Y I + A +++Y+ L R +L+NL +
Sbjct: 827 QLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSK--ILMNLSTALLFLN 884
Query: 810 VVFV--GGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEP 867
++F+ G IT +C AV ++LH+ LAT W+G+ A ++Y + K
Sbjct: 885 LLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTY------ 938
Query: 868 PPPPRPMLRFYLIGGGIPIIVCGITAAANIKN-------YGSRPNAPYCWMAWEPSLGAF 920
R +L+F +IG G+P +V + A+ N YG +CW+ +P + F
Sbjct: 939 --IRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQ-DPVI--F 993
Query: 921 Y----GPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSM 976
Y G + F+N F+ + +Q+ NG+ +++
Sbjct: 994 YVTCAGYFGVMFFLNIAMFIVVMVQI---------------------CGRNGKRSNR--- 1029
Query: 977 SLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSL 1036
+ L N + SLT LL + W F A + PL++ F ++F +
Sbjct: 1030 ---TLREEVLRNLRSV------VSLTFLLGMT-WGFAFFA---WGPLNIPFMYLFSIFNS 1076
Query: 1037 SFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAES 1096
F + HC +E+V+ W C GR + N + K + +
Sbjct: 1077 LQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLA------------DNSDWSKTATNIIKK 1124
Query: 1097 SCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHSMD 1148
S N S +SS G T L + + NS DN EHS +
Sbjct: 1125 SSDN-LGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNS--HTDNVSYEHSFN 1173
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 108 bits (269), Expect = 4e-23
Identities = 65/199 (32%), Positives = 98/199 (49%), Gaps = 27/199 (13%)
Query: 63 VVCSSLELAQVLPPDTLPNRTVTLIL-------------------------SNNKISELK 97
V CSSL+L ++ P+ +P T L L SNNK+SE++
Sbjct: 524 VECSSLKLTKI--PERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIE 581
Query: 98 NGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVR 157
+G+F G + + L L N + SI G F GL L+ L L NNRI C++ D F GL N+
Sbjct: 582 DGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRL 641
Query: 158 LNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYP 217
L+L N +++S G FD L SL +L C+C + W+ W++++ I + RC P
Sbjct: 642 LSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNP 701
Query: 218 KSLQAQPVTGVKQELLTCD 236
L+ P+ V C+
Sbjct: 702 DFLRQIPLQDVAFPDFRCE 720
Score = 98.2 bits (243), Expect = 5e-20
Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 2/164 (1%)
Query: 74 LPPDTL-PNRTVTLI-LSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSL 131
+PP P R + I LSNN+I+E+ +F GL L L L N I+ + G F GL +L
Sbjct: 324 IPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTL 383
Query: 132 KRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLC 191
+ L L N+I C+ D F+ L NL L+L N SL++GTF L ++++L +C
Sbjct: 384 QLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFIC 443
Query: 192 DCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTC 235
DCN+ W+ +++ I RC P+ L + + +K + C
Sbjct: 444 DCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRC 487
Score = 91.3 bits (225), Expect = 6e-18
Identities = 47/150 (31%), Positives = 78/150 (52%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L+ N++ L F L RLDL N I +I AF G + LK L L N+I C+
Sbjct: 114 LRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIE 173
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEK 205
FR L L L L+ N +++ +F+++ LR+ + +L CDC++ W+ +W++++
Sbjct: 174 EGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQR 233
Query: 206 NITVRDTRCVYPKSLQAQPVTGVKQELLTC 235
T+C P SL+ V V++ +C
Sbjct: 234 PTIGLFTQCSGPASLRGLNVAEVQKSEFSC 263
Score = 86.3 bits (212), Expect = 2e-16
Identities = 55/176 (31%), Positives = 83/176 (47%), Gaps = 3/176 (1%)
Query: 63 VVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDP 122
V CS+ L + P +P L L N+ + L G S L+ +DL NN ISS+
Sbjct: 745 VRCSNKHLRAL--PKGIPKNVTELYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSLSN 801
Query: 123 GAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSL 182
+F +S L L L+ N + C+ F+GL +L L+L GN S+L +G F + SL L
Sbjct: 802 SSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHL 861
Query: 183 EFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPP 238
L CDC++ W+ WVK RC P+ ++ + + + C P
Sbjct: 862 AIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGP 917
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 107 bits (266), Expect = 1e-22
Identities = 95/324 (29%), Positives = 143/324 (44%), Gaps = 39/324 (12%)
Query: 85 TLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
TL+L+NN+I + +G+F L L+ L L N I SID AF GL+SL++L L N+I L
Sbjct: 90 TLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETL 149
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVK- 203
+ D F+ L L RL L N + L GTF++L S++ L + L CDC ILW+ +K
Sbjct: 150 DPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKT 209
Query: 204 --EKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP 261
E C YP+ +Q + V + E L C E P P V G+++
Sbjct: 210 YAESGNAQAAAICEYPRRIQGRSVATITPEELNC----ERPRITSEPQDADVT-SGNTVY 264
Query: 262 FQCMASYIDQDMQVLWYQDGR--IVETDESQGIFVEKNMIHNCSLIASALTISNIQAGST 319
F C A + +++W ++ ++TD + L L I N Q
Sbjct: 265 FTCRAEG-NPKPEIIWLRNNNELSMKTDSRLNL-----------LDDGTLMIQNTQETDQ 312
Query: 320 GNWGCHVQTKRGN-NTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTR 378
G + C + G T+ V + S A+ P V+ + L G + L+C+
Sbjct: 313 GIYQCMAKNVAGEVKTQEVTLRYFGSPAR---PTFVIQPQN----TEVLVGESVTLECSA 365
Query: 379 NTHGSGIYPGNPQDERKAWRRCDR 402
H R +W R DR
Sbjct: 366 TGH---------PPPRISWTRGDR 380
>gi|6912464 latrophilin 2 precursor [Homo sapiens]
Length = 1403
Score = 107 bits (266), Expect = 1e-22
Identities = 128/552 (23%), Positives = 230/552 (41%), Gaps = 84/552 (15%)
Query: 631 DSLYKLQLIAFRNGKLFPATGNST-NLADD--GKRRTVVTPVILTKIDGVNVDTHHI--- 684
+ L KL I +R+ F +T N+T L D G+ T+ + + +N ++ +
Sbjct: 697 NGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVS-INKESSRVYLT 755
Query: 685 -PVNVTLRRIA--HGADAVAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYA 741
PV TL I + +A + W++ G W + GC ++ +++ TT C L+N+A
Sbjct: 756 DPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFA 815
Query: 742 VLMDLTGSELYTQAASLLHPVVYTTAIIL-LLCLLAVIVSYIYHHSLIRISLKSWHMLVN 800
+LM LL V+ I++ L+CL I ++ + L + + H N
Sbjct: 816 ILMAHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGL-QSDRNTIHK--N 872
Query: 801 LCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKR 860
LC ++F+ +F+ GI +T+ A C +LH+ LA W+ + +Y + + +
Sbjct: 873 LCINLFIAEFIFLIGIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFES 932
Query: 861 CQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP-SLGA 919
+ +Y+ G P V G++AA + K+YG+ CW+ + + +
Sbjct: 933 EYSRKK---------YYYVAGYLFPATVVGVSAAIDYKSYGTE---KACWLHVDNYFIWS 980
Query: 920 FYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSMSLS 979
F GP +FI +N ++ + ++ +H LK
Sbjct: 981 FIGPVTFIILLNIIFLVITLCKMVKHSN---TLKP------------------------- 1012
Query: 980 LISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFS 1039
+S LEN S +LGA L L W FG L ++ +V +++F +
Sbjct: 1013 --DSSRLEN---IKSWVLGAFALLCLLGLTWSFGLLFIN---EETIVMAYLFTIFNAFQG 1064
Query: 1040 AFFVVHHCVNREDVRLAW-----IMTCCPGRSSYSVQVNVQPPN-------SNGTNGEAP 1087
F + HC ++ VR + CC G + S +V+ S+GT
Sbjct: 1065 VFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIR 1124
Query: 1088 KCPNSS----AESSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLT 1143
+ N + +ESS + +S +QG L N + +A ++LPLN +NS +
Sbjct: 1125 RMWNDTVRKQSESSFISGDINSTSTLNQGHSLNNARDTSAM---DTLPLNG--NFNNSYS 1179
Query: 1144 EHSMDNDIKMHV 1155
H D + + V
Sbjct: 1180 LHKGDYNDSVQV 1191
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 103 bits (257), Expect = 1e-21
Identities = 51/149 (34%), Positives = 87/149 (58%)
Query: 88 LSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNAD 147
LSNNKI E++ G+F G + ++ L L N + ++ F GLS LK L L +N IGC++ D
Sbjct: 564 LSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623
Query: 148 IFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNI 207
F GL+++ L+L N ++++ G F L SL ++ + C+C++ W+ +W++++ I
Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRI 683
Query: 208 TVRDTRCVYPKSLQAQPVTGVKQELLTCD 236
+ RC P L+ P+ V + TCD
Sbjct: 684 VSGNPRCQKPFFLKEIPIQDVAIQDFTCD 712
Score = 94.7 bits (234), Expect = 5e-19
Identities = 50/157 (31%), Positives = 80/157 (50%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L+ NK+ L F L RLDL N I I AF G++ +K L L NN I C+
Sbjct: 114 LRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIE 173
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEK 205
FR L +L L L+ N S + +F+++ +R+L + +L CDC++ W+ W++++
Sbjct: 174 DGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR 233
Query: 206 NITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELP 242
+ T C+ P L+ V V+++ C P P
Sbjct: 234 RTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEP 270
Score = 90.5 bits (223), Expect = 1e-17
Identities = 49/148 (33%), Positives = 80/148 (54%)
Query: 88 LSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNAD 147
+S N+IS++ +F GL L L L N I+ I G F GL SL+ L L N+I CL +
Sbjct: 338 ISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVN 397
Query: 148 IFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNI 207
F+ L NL L+L N ++S+G F L S+++L +CDC++ W+ ++++ I
Sbjct: 398 TFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPI 457
Query: 208 TVRDTRCVYPKSLQAQPVTGVKQELLTC 235
RC P+ L + ++ +K + C
Sbjct: 458 ETSGARCSSPRRLANKRISQIKSKKFRC 485
Score = 83.6 bits (205), Expect = 1e-15
Identities = 57/182 (31%), Positives = 84/182 (46%), Gaps = 3/182 (1%)
Query: 60 EGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISS 119
E V CS+ L + P +P L L N ++ + S L L +DL NN IS
Sbjct: 733 ETVVRCSNKGLRAL--PRGMPKDVTELYLEGNHLTAVPR-ELSALRHLTLIDLSNNSISM 789
Query: 120 IDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASL 179
+ F +S L L L+ NR+ C+ F GL +L L L GN SS+ +G+F+ L SL
Sbjct: 790 LTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSL 849
Query: 180 RSLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPL 239
L T L CDC++ W+ WVK RC P+ + + + C P+
Sbjct: 850 SHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPV 909
Query: 240 EL 241
++
Sbjct: 910 DI 911
>gi|163792198 latrophilin 3 precursor [Homo sapiens]
Length = 1469
Score = 103 bits (256), Expect = 1e-21
Identities = 91/375 (24%), Positives = 163/375 (43%), Gaps = 54/375 (14%)
Query: 704 WDFDLLNGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVV 763
W + G W + GC +L +++ TT C L+N+AVLM + LL V+
Sbjct: 821 WSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVI 880
Query: 764 YTTAIIL-LLCLLAVIVSYIYHHSLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNA 822
I+L L+CLL I ++ + L + + H NLC +F+ ++F+ GI +T
Sbjct: 881 TWVGILLSLVCLLICIFTFCFFRGL-QSDRNTIHK--NLCISLFVAELLFLIGINRTDQP 937
Query: 823 SICQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGG 882
C +LH+ LA W+ + +Y + + + + FYL+G
Sbjct: 938 IACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRK---------YFYLVGY 988
Query: 883 GIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP-SLGAFYGPASFITFVNCMYFLSIFIQ 941
G+P ++ ++AA + ++YG+ CW+ + + +F GPA+ I +N + FL I +
Sbjct: 989 GMPALIVAVSAAVDYRSYGT---DKVCWLRLDTYFIWSFIGPATLIIMLN-VIFLGIALY 1044
Query: 942 LKRHPERKYELKEPTEEQQRLAANENG---EINHQDSMSLSLISTSALENEHTFHSQLLG 998
H + E+G IN++D N S ++G
Sbjct: 1045 KMFH-------------HTAILKPESGCLDNINYED-------------NRPFIKSWVIG 1078
Query: 999 ASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAW- 1057
A L L W FG + ++ ++ +++F + F + HCV ++ VR +
Sbjct: 1079 AIALLCLLGLTWAFGLMYIN---ESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYG 1135
Query: 1058 --IMT-CCPGRSSYS 1069
+ T CC G+S+ S
Sbjct: 1136 KCLRTHCCSGKSTES 1150
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 102 bits (255), Expect = 2e-21
Identities = 124/540 (22%), Positives = 208/540 (38%), Gaps = 93/540 (17%)
Query: 684 IPVNVTLRRIAHGADAVAARWDFDLLNGQGG-WKSDGCHILYSDENITTIQCYSLSNYAV 742
I + L + A+ + A+ +WD L Q G W + C +++ + + +C + V
Sbjct: 2463 ISLEFRLLQTANRSKAICVQWDPPGLAEQHGVWTARDCELVHRNGSHARCRCSRTGTFGV 2522
Query: 743 LMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWHMLV--- 799
LMD + E LL V+T ++ AV V+ + + I +SL+S V
Sbjct: 2523 LMDASPRERLEGDLELL--AVFTHVVV------AVSVAALVLTAAILLSLRSLKSNVRGI 2574
Query: 800 --NLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTKK 857
N+ + + ++F+ GI +T N +C AV I+LHY L+T W+ V ++Y+
Sbjct: 2575 HANVAAALGVAELLFLLGIHRTHNQLVCTAVAILLHYFFLSTFAWLFVQGLHLYRMQV-- 2632
Query: 858 AKRCQDPDEPPPPPRPMLRFY-LIGGGIPIIVCGITAAANIKNYGSRPNAPYCWMA-WEP 915
EP R +RFY +G G+P ++ G+ + + YG N +CW++ EP
Sbjct: 2633 --------EPRNVDRGAMRFYHALGWGVPAVLLGLAVGLDPEGYG---NPDFCWISVHEP 2681
Query: 916 SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDS 975
+ +F GP + +N FL LAA +
Sbjct: 2682 LIWSFAGPVVLVIVMNGTMFL-------------------------LAARTS-------- 2708
Query: 976 MSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGATS 1035
ST E + T L + L LLL A W+FG LAV+ L F ++
Sbjct: 2709 -----CSTGQREAKKTSALTLRSSFLLLLLVSASWLFGLLAVNHSI---LAFHYLHAGLC 2760
Query: 1036 LSFSAFFVVHHCVNREDVRLAWIMTCCPGRSSYSVQVNVQPPNSNGTNGEAPKCPNSSAE 1095
++ CV D R AW M C GR + + P G S
Sbjct: 2761 GLQGLAVLLLFCVLNADARAAW-MPACLGRKAAPEEARPAPGLGPGAYNNTALFEESGLI 2819
Query: 1096 SSCTNKSASSFKNSSQGCKLTNLQAAAAQCHANSLPLNSTPQLDNSLTEHS-----MDND 1150
S S +S++ + + + + + DN L H D+
Sbjct: 2820 RITLGASTVSSVSSARSGRTQDQDSQRGRSYLR----------DNVLVRHGSAADHTDHS 2869
Query: 1151 IKMHVAPLEVQFRTNVHSSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSR 1210
++ H P ++ + H + S L++ E + +P+S S NG + R
Sbjct: 2870 LQAHAGPTDLDV-----AMFHRDAGADSDSDSDLSLEEERSLSIPSS--ESEDNGRTRGR 2922
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 102 bits (255), Expect = 2e-21
Identities = 81/280 (28%), Positives = 122/280 (43%), Gaps = 30/280 (10%)
Query: 82 RTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRI 141
R L LS N+++ L +F GLSLLERL+L +N ++ I G F LS+L+ LDL NN I
Sbjct: 312 RLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEI 371
Query: 142 GCLNAD---IFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLE--------------- 183
D F GLT+L +L L GN S+++ F L SL L+
Sbjct: 372 SWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFS 431
Query: 184 --------FQTEYLLCDCNILWMHRWVKEKNITVR-DTRCVYPKSLQAQPVTGVKQELLT 234
T LLCDC++ W+ +W+ + N + C +P+ L Q + V +
Sbjct: 432 QTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFV 491
Query: 235 CDPPLELPSFYMTPSHRQVVFEGDSLPFQCMA-SYIDQDMQVLWYQDGRIVETDESQGIF 293
CD L+ P P + G ++ C A S D M +W +D I+ +++
Sbjct: 492 CDDFLK-PQIRTHP-ETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFV 549
Query: 294 VEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNN 333
S L + N+ G + C V G+N
Sbjct: 550 RYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589
Score = 60.8 bits (146), Expect = 8e-09
Identities = 34/105 (32%), Positives = 58/105 (55%)
Query: 81 NRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNR 140
N L L +N ++ + G GL +L++L + N I I P A+ L LDL+ N+
Sbjct: 263 NNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQ 322
Query: 141 IGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQ 185
+ L+ F GL+ L RLNL N + ++ G F +L++L++L+ +
Sbjct: 323 LTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLR 367
Score = 53.5 bits (127), Expect = 1e-06
Identities = 31/104 (29%), Positives = 54/104 (51%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L N+I ++ +F GL L L ++ N IS + GAF+GL++++ L+L +N + +N
Sbjct: 220 LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN 279
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYL 189
GL L +L +S N +S +++ L L+ L
Sbjct: 280 KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQL 323
Score = 50.1 bits (118), Expect = 1e-05
Identities = 38/101 (37%), Positives = 52/101 (51%), Gaps = 2/101 (1%)
Query: 86 LILSNNKISELKNGSFSGLSL-LERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
L LSNN+I+ L+ G F LS L + L N +S I P F L L+ L+L NRI +
Sbjct: 172 LNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRIKIV 230
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQ 185
F+GL +L L + N S L G F L ++ LE +
Sbjct: 231 EGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELE 271
Score = 44.7 bits (104), Expect = 6e-04
Identities = 43/131 (32%), Positives = 60/131 (45%), Gaps = 26/131 (19%)
Query: 80 PNRTVTLI-LSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTN 138
P +TL+ L +N I E+ + LE LDL +N+IS I +F + LK L+L+N
Sbjct: 118 PTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN 176
Query: 139 NRIGCLNADIFRGLTN---LVRLN---------------------LSGNLFSSLSQGTFD 174
NRI L A F L++ +V+LN L N + TF
Sbjct: 177 NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQ 236
Query: 175 YLASLRSLEFQ 185
L SLRSL+ Q
Sbjct: 237 GLDSLRSLKMQ 247
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 102 bits (253), Expect = 3e-21
Identities = 73/252 (28%), Positives = 110/252 (43%), Gaps = 7/252 (2%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSI---DPGAFWGLSSLKRLDLTNNRIG 142
L LS+N IS + G+F GL L LDL +N IS GAF GL SL +L L N+I
Sbjct: 336 LRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIK 395
Query: 143 CLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWV 202
+ F GL L LNL GN S+ F + +L+ L ++ LCDC + W+ W+
Sbjct: 396 SVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWL 455
Query: 203 KEKNITVRDT-RCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLP 261
+ + T C +P+SL+ Q + V E CD L+ P +T + G +
Sbjct: 456 IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLK-PQI-ITQPETTMAMVGKDIR 513
Query: 262 FQC-MASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTG 320
F C AS M W +D ++ + + + L + + G G
Sbjct: 514 FTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEG 573
Query: 321 NWGCHVQTKRGN 332
+ C + G+
Sbjct: 574 RYQCVITNHFGS 585
Score = 59.7 bits (143), Expect = 2e-08
Identities = 36/101 (35%), Positives = 55/101 (54%)
Query: 82 RTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRI 141
R L L+ N+I ++ +F GL+ LE L L+ N IS + GAFWGLS + L L N +
Sbjct: 212 RLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSL 271
Query: 142 GCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSL 182
+N+ GLT L +L+LS N + + + + + L L
Sbjct: 272 VEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHEL 312
Score = 53.5 bits (127), Expect = 1e-06
Identities = 39/127 (30%), Positives = 61/127 (48%), Gaps = 24/127 (18%)
Query: 81 NRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNR 140
N L L N IS+L +G+F GLS + L L N + ++ G+ +GL++L +L L+NN
Sbjct: 235 NSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNS 294
Query: 141 IGCLNA----------DIFRGLTNLVRLN--------------LSGNLFSSLSQGTFDYL 176
I ++ ++ NL RL+ LS N S +++G F L
Sbjct: 295 IARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGL 354
Query: 177 ASLRSLE 183
SLR L+
Sbjct: 355 RSLRVLD 361
Score = 50.8 bits (120), Expect = 8e-06
Identities = 39/106 (36%), Positives = 54/106 (50%), Gaps = 2/106 (1%)
Query: 86 LILSNNKISELKNGSFSGLSL-LERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCL 144
L L+ N+I L+ G+F GLS L L L N I+ + AF L L +LDL NRI +
Sbjct: 168 LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLI 226
Query: 145 NADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLL 190
F+GL +L L L N S L+ G F L+ + L + L+
Sbjct: 227 EGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLV 272
Score = 50.8 bits (120), Expect = 8e-06
Identities = 38/106 (35%), Positives = 54/106 (50%), Gaps = 1/106 (0%)
Query: 77 DTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDL 136
D L +TL LS N+I++L +F L L +LDL N I I+ F GL+SL+ L L
Sbjct: 184 DGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKL 242
Query: 137 TNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSL 182
N I L F GL+ + L+L N ++ G+ L +L L
Sbjct: 243 QRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQL 288
Score = 47.0 bits (110), Expect = 1e-04
Identities = 36/113 (31%), Positives = 52/113 (46%), Gaps = 1/113 (0%)
Query: 62 KVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSID 121
+V ++ EL V + V+L L +NKI ++ LE LDL N I+ +
Sbjct: 96 EVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVR 155
Query: 122 PGAFWGLSSLKRLDLTNNRIGCLNADIFRGLT-NLVRLNLSGNLFSSLSQGTF 173
F +K L+L NRIG L F GL+ +L+ L LS N + L F
Sbjct: 156 NTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAF 208
Score = 44.7 bits (104), Expect = 6e-04
Identities = 55/193 (28%), Positives = 72/193 (37%), Gaps = 34/193 (17%)
Query: 8 RGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAEGKVVCSS 67
RG P P LL L LL AA A C A A + C
Sbjct: 6 RGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPC---------AAACTCAGDSLDCGG 56
Query: 68 LELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNN------------ 115
LA + P LP+ T +L LS NK+SE+ F L L+ + L NN
Sbjct: 57 RGLAAL--PGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS 114
Query: 116 -----------LISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNL 164
I S++ SL+ LDL+ N I + F + LNL+GN
Sbjct: 115 SHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNR 174
Query: 165 FSSLSQGTFDYLA 177
+L G FD L+
Sbjct: 175 IGTLELGAFDGLS 187
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 101 bits (252), Expect = 4e-21
Identities = 110/464 (23%), Positives = 184/464 (39%), Gaps = 55/464 (11%)
Query: 608 EASIQLPPSLFSPKQKRELRPTDDSLYKLQLIAFRNGKLFPATGNSTNLADDGKRRTVVT 667
E + +P S+F+P +EL + S++ L + ++N L T + TV+
Sbjct: 736 EDRVVIPKSIFTPVSSKEL--DESSVFVLGAVLYKNLDLILPTL---------RNYTVIN 784
Query: 668 PVILTKIDGVNVDTHHIPVNVTLRRIAHGA-DAVAARWDFDLLNGQ-GGWKSDGCHILYS 725
I+ T + + L +A+G + WD N G W + GC + +
Sbjct: 785 SKIIVVTIRPEPKTTDSFLEIELAHLANGTLNPYCVLWDDSKTNESLGTWSTQGCKTVLT 844
Query: 726 DENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTTAIILLLCLLAVIVSYIYHH 785
D + T C LS +A+L + + + P V L CL + ++ +Y
Sbjct: 845 DASHTKCLCDRLSTFAILAQQPREIIMESSGT---PSVTLIVGSGLSCLALITLAVVYAA 901
Query: 786 SLIRISLKSWHMLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGV 845
I + +L+N C I + ++ + G TQT N SIC LH+ LA+ WV
Sbjct: 902 LWRYIRSERSIILINFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLT 961
Query: 846 TARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIPIIVCGITAA-ANIKNYGSRP 904
A Y VT K + RF +G G+P +V + K YG+
Sbjct: 962 EAWQSYMAVTGKIR----------TRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGT-- 1009
Query: 905 NAPYCWMAWEPS-LGAFYGPASFITFVNCMYFLSIFIQL--------KRHPERKYELKEP 955
YCW++ E L AF GPA+ + VN + + +F +L K+ R ++ EP
Sbjct: 1010 -DHYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEP 1068
Query: 956 TEEQQRLAANENGEINHQDSMSLSLISTSALE--NEHTFHSQLLGASLTLLLYVALWMFG 1013
A ++ST+AL + L + + L L WM
Sbjct: 1069 HSGLTLKCA------------KCGVVSTTALSATTASNAMASLWSSCVVLPLLALTWMSA 1116
Query: 1014 ALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAW 1057
LA++ ++F +F V+ HC+ R +V+ A+
Sbjct: 1117 VLAMT--DKRSILFQILFAVFDSLQGFVIVMVHCILRREVQDAF 1158
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 100 bits (249), Expect = 9e-21
Identities = 52/148 (35%), Positives = 84/148 (56%)
Query: 89 SNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADI 148
SNNKI++++ G+F G S + + L +N + ++ F GL SLK L L +NRI C+ D
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625
Query: 149 FRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEKNIT 208
F GL+++ L+L N ++++ G FD L SL +L C+C + W+ W+++K I
Sbjct: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIV 685
Query: 209 VRDTRCVYPKSLQAQPVTGVKQELLTCD 236
+ RC P L+ P+ V + TCD
Sbjct: 686 TGNPRCQKPYFLKEIPIQDVAIQDFTCD 713
Score = 94.4 bits (233), Expect = 7e-19
Identities = 55/166 (33%), Positives = 87/166 (52%), Gaps = 2/166 (1%)
Query: 72 QVLPPDTL-PNRTVTLI-LSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLS 129
+V+PP P + + I LSNN+ISEL +F GL L L L N I+ + F GL
Sbjct: 313 KVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLF 372
Query: 130 SLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYL 189
SL+ L L N+I CL D F+ L NL L+L N ++++GTF L +++++
Sbjct: 373 SLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPF 432
Query: 190 LCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTC 235
+CDC++ W+ ++ I RC P+ L + + +K + C
Sbjct: 433 ICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRC 478
Score = 85.9 bits (211), Expect = 2e-16
Identities = 47/150 (31%), Positives = 75/150 (50%)
Query: 86 LILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLN 145
L L+ N + F G + L RLDL N I +I AF G +K L L N+I C+
Sbjct: 108 LRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIE 167
Query: 146 ADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNILWMHRWVKEK 205
FR L +L L L+ N + LS +F+++ LR+ + L CDC++ W+ W++++
Sbjct: 168 DGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQR 227
Query: 206 NITVRDTRCVYPKSLQAQPVTGVKQELLTC 235
T+C+ P L+ V V++ C
Sbjct: 228 PRVGLYTQCMGPSHLRGHNVAEVQKREFVC 257
Score = 81.6 bits (200), Expect = 4e-15
Identities = 56/179 (31%), Positives = 87/179 (48%), Gaps = 3/179 (1%)
Query: 63 VVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDP 122
V CS+ L +VLP +P L L N+ + L S L +DL NN IS++
Sbjct: 738 VRCSNKGL-KVLPKG-IPRDVTELYLDGNQFT-LVPKELSNYKHLTLIDLSNNRISTLSN 794
Query: 123 GAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSL 182
+F ++ L L L+ NR+ C+ F GL +L L+L GN S + +G F+ L++L L
Sbjct: 795 QSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHL 854
Query: 183 EFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLEL 241
L CDCN+ W+ WVK + RC P + + + + TC P+++
Sbjct: 855 AIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDV 913
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 98.2 bits (243), Expect = 5e-20
Identities = 93/417 (22%), Positives = 179/417 (42%), Gaps = 71/417 (17%)
Query: 658 DDGKRRTVVTPVILTKIDGVNV-DTHHI-------PVNVTLRRIA--HGADAVAARWDFD 707
D R P+I T + ++V D + PV V R + + W+
Sbjct: 2266 DKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKPICVFWNHS 2325
Query: 708 LL-NGQGGWKSDGCHILYSDENITTIQCYSLSNYAVLMDLTGSELYTQAASLLHPVVYTT 766
+L +G GGW + GC +++ +E+ + QC ++++AVLMD++ E + P+ T
Sbjct: 2326 ILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRE-----NGEILPLKTLT 2380
Query: 767 AIILLLCLLAVIVSYIYHHSLIRISLKSWH-MLVNLCFHIFLTCVVFVGGITQTRNASIC 825
+ L + L A+++++ + +L+RI + H + NL + L +VF+ GI Q C
Sbjct: 2381 YVALGVTLAALLLTFFF-LTLLRILRSNQHGIRRNLTAALGLAQLVFLLGINQADLPFAC 2439
Query: 826 QAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEPPPPPRPMLRFYLIGGGIP 885
+ I+LH+ L T W + A ++Y+ +T+ +D + PM +Y++G G+P
Sbjct: 2440 TVIAILLHFLYLCTFSWALLEALHLYRALTE----VRDVN-----TGPMRFYYMLGWGVP 2490
Query: 886 IIVCGITAAANIKNYGSRPNAPYCWMA-WEPSLGAFYGPASFITFVNCMYFLSIFIQLKR 944
+ G+ + + YG N +CW++ ++ + +F GP +F ++ ++
Sbjct: 2491 AFITGLAVGLDPEGYG---NPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLYILAARASCA 2547
Query: 945 HPERKYELKEPTEEQQRLAANENGEINHQDSMSLSLISTSALENEHTFHSQLLGASLTLL 1004
+ +E K P S L + LL
Sbjct: 2548 AQRQGFEKKGPV-------------------------------------SGLQPSFAVLL 2570
Query: 1005 LYVALWMFGALAVSLYYPLDLVFSFVFGATSLSFSAFFVVHHCVNREDVRLAWIMTC 1061
L A W+ L+V+ L+F ++F + F + + V ++VR A + C
Sbjct: 2571 LLSATWLLALLSVN---SDTLLFHYLFATCNCIQGPFIFLSYVVLSKEVRKALKLAC 2624
>gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens]
Length = 1474
Score = 97.8 bits (242), Expect = 6e-20
Identities = 114/479 (23%), Positives = 198/479 (41%), Gaps = 80/479 (16%)
Query: 631 DSLYKLQLIAFRNGKLFPATGNST-NLADD-------GKRRTVVTPVILTKIDGVNVDTH 682
+ + K+ I + N LF +T N+T LA + G V + VI I+ +
Sbjct: 721 NGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASIN--KESSR 778
Query: 683 HIPVNVTLRRIAHGAD-----AVAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSL 737
++ + +AH D A + W++ + G W + GC ++ S++ TT C L
Sbjct: 779 VFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHL 838
Query: 738 SNYAVLMDLTGSELYT-QAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWH 796
+N+AVLM E+Y + LL V+ I++ L LA+ +S ++ + H
Sbjct: 839 TNFAVLM--AHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIH 896
Query: 797 MLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTK 856
NLC ++FL ++F+ GI +T+ C +LHY LA W+ + ++Y +
Sbjct: 897 K--NLCINLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLV- 953
Query: 857 KAKRCQDPDEPPPPPRPMLRFYLIGG-GIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP 915
E ++Y +GG P +V GI AA + ++YG+ CW+ +
Sbjct: 954 ---------EVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTE---KACWLRVDN 1001
Query: 916 -SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQD 974
+ +F GP SF+ VN ++ + ++ R
Sbjct: 1002 YFIWSFIGPVSFVIVVNLVFLMVTLHKMIR------------------------------ 1031
Query: 975 SMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGAT 1034
S S+ +S L+N S LGA L L W FG L ++ +V +++F
Sbjct: 1032 SSSVLKPDSSRLDN---IKSWALGAIALLFLLGLTWAFGLLFIN---KESVVMAYLFTTF 1085
Query: 1035 SLSFSAFFVVHHC-----VNREDVRLAWIMTCC----PGRSSYSVQVNVQPPNSNGTNG 1084
+ F V HC V++E + CC PG + S++ + N+ G
Sbjct: 1086 NAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTG 1144
>gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens]
Length = 1469
Score = 97.8 bits (242), Expect = 6e-20
Identities = 114/479 (23%), Positives = 198/479 (41%), Gaps = 80/479 (16%)
Query: 631 DSLYKLQLIAFRNGKLFPATGNST-NLADD-------GKRRTVVTPVILTKIDGVNVDTH 682
+ + K+ I + N LF +T N+T LA + G V + VI I+ +
Sbjct: 716 NGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASIN--KESSR 773
Query: 683 HIPVNVTLRRIAHGAD-----AVAARWDFDLLNGQGGWKSDGCHILYSDENITTIQCYSL 737
++ + +AH D A + W++ + G W + GC ++ S++ TT C L
Sbjct: 774 VFLMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHL 833
Query: 738 SNYAVLMDLTGSELYT-QAASLLHPVVYTTAIILLLCLLAVIVSYIYHHSLIRISLKSWH 796
+N+AVLM E+Y + LL V+ I++ L LA+ +S ++ + H
Sbjct: 834 TNFAVLM--AHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIH 891
Query: 797 MLVNLCFHIFLTCVVFVGGITQTRNASICQAVGIILHYSTLATVLWVGVTARNIYKQVTK 856
NLC ++FL ++F+ GI +T+ C +LHY LA W+ + ++Y +
Sbjct: 892 K--NLCINLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLV- 948
Query: 857 KAKRCQDPDEPPPPPRPMLRFYLIGG-GIPIIVCGITAAANIKNYGSRPNAPYCWMAWEP 915
E ++Y +GG P +V GI AA + ++YG+ CW+ +
Sbjct: 949 ---------EVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTE---KACWLRVDN 996
Query: 916 -SLGAFYGPASFITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQD 974
+ +F GP SF+ VN ++ + ++ R
Sbjct: 997 YFIWSFIGPVSFVIVVNLVFLMVTLHKMIR------------------------------ 1026
Query: 975 SMSLSLISTSALENEHTFHSQLLGASLTLLLYVALWMFGALAVSLYYPLDLVFSFVFGAT 1034
S S+ +S L+N S LGA L L W FG L ++ +V +++F
Sbjct: 1027 SSSVLKPDSSRLDN---IKSWALGAIALLFLLGLTWAFGLLFIN---KESVVMAYLFTTF 1080
Query: 1035 SLSFSAFFVVHHC-----VNREDVRLAWIMTCC----PGRSSYSVQVNVQPPNSNGTNG 1084
+ F V HC V++E + CC PG + S++ + N+ G
Sbjct: 1081 NAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTG 1139
>gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens]
Length = 548
Score = 96.7 bits (239), Expect = 1e-19
Identities = 56/160 (35%), Positives = 80/160 (50%)
Query: 76 PDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLD 135
P LP+ ++L L N SE+++G+FS L LL+ L L +N + I AF GLS L+ L
Sbjct: 59 PRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLF 118
Query: 136 LTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNI 195
+ NN I L+ FRGL +L L+L+ N +L + F L L L+ + L CDC +
Sbjct: 119 IENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKV 178
Query: 196 LWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTC 235
W+ W+ N TV C P Q V + C
Sbjct: 179 KWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDC 218
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,747,378
Number of Sequences: 37866
Number of extensions: 2398604
Number of successful extensions: 13442
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 11355
Number of HSP's gapped (non-prelim): 1398
length of query: 1321
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1207
effective length of database: 13,930,794
effective search space: 16814468358
effective search space used: 16814468358
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.