BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b [Homo sapiens] (1814 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 3533 0.0 gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 3413 0.0 gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 226 2e-58 gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 226 2e-58 gi|71061468 centromere protein E [Homo sapiens] 134 6e-31 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 130 9e-30 gi|50658075 phosphodiesterase 4D interacting protein isoform 3 [... 127 8e-29 gi|50658077 phosphodiesterase 4D interacting protein isoform 4 [... 120 2e-26 gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 116 2e-25 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 116 2e-25 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 115 4e-25 gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 113 1e-24 gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 113 1e-24 gi|55770834 centromere protein F [Homo sapiens] 111 7e-24 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 110 1e-23 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 110 1e-23 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 110 1e-23 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 110 1e-23 gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 107 1e-22 gi|31982906 cingulin-like 1 [Homo sapiens] 105 5e-22 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 104 7e-22 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 103 1e-21 gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 103 2e-21 gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 100 1e-20 gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 100 1e-20 gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 99 5e-20 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 98 6e-20 gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 98 6e-20 gi|32698688 citron [Homo sapiens] 97 2e-19 gi|42794779 myosin 18A isoform b [Homo sapiens] 97 2e-19 >gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b [Homo sapiens] Length = 1814 Score = 3533 bits (9162), Expect = 0.0 Identities = 1814/1814 (100%), Positives = 1814/1814 (100%) Query: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM Sbjct: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60 Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240 Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR Sbjct: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300 Query: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT Sbjct: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360 Query: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK Sbjct: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420 Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK Sbjct: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF Sbjct: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS Sbjct: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600 Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL Sbjct: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660 Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE Sbjct: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL Sbjct: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780 Query: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN Sbjct: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840 Query: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN Sbjct: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900 Query: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV Sbjct: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960 Query: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS Sbjct: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 Query: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT Sbjct: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080 Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS Sbjct: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140 Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE Sbjct: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200 Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI Sbjct: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260 Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK Sbjct: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320 Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET Sbjct: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380 Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS Sbjct: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440 Query: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS Sbjct: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500 Query: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE Sbjct: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560 Query: 1561 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS 1620 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS Sbjct: 1561 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS 1620 Query: 1621 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP 1680 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP Sbjct: 1621 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP 1680 Query: 1681 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG 1740 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG Sbjct: 1681 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG 1740 Query: 1741 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG 1800 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG Sbjct: 1741 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG 1800 Query: 1801 GAHPGTCSPSRPGS 1814 GAHPGTCSPSRPGS Sbjct: 1801 GAHPGTCSPSRPGS 1814 >gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a [Homo sapiens] Length = 1893 Score = 3413 bits (8850), Expect = 0.0 Identities = 1780/1893 (94%), Positives = 1795/1893 (94%), Gaps = 79/1893 (4%) Query: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM Sbjct: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60 Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240 Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR Sbjct: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300 Query: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT Sbjct: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360 Query: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK Sbjct: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420 Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK Sbjct: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF Sbjct: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS Sbjct: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600 Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL Sbjct: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660 Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE Sbjct: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL Sbjct: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780 Query: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN Sbjct: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840 Query: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN Sbjct: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900 Query: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV Sbjct: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960 Query: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS Sbjct: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 Query: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT Sbjct: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080 Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS Sbjct: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140 Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE Sbjct: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200 Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI Sbjct: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260 Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK Sbjct: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320 Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET Sbjct: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380 Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS Sbjct: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440 Query: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS Sbjct: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500 Query: 1501 VKEENERLQKEGSEKERHNQQLIQ--------------EVRCSGQELSR-------VQEE 1539 VKEENERLQKEGSEKERHNQQLIQ EV+ Q LS+ ++ E Sbjct: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560 Query: 1540 VKLRQQLLSQNDKL-----------------------LQSLRVEL--------------- 1561 +K ++L ++ +L +Q+LR++L Sbjct: 1561 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620 Query: 1562 ----KAYEKLDEEHRRL----------------RDGDKYPMESDNSFDLFDSSQAVTPKS 1601 + EK E L DGDKYPMESDNSFDLFDSSQAVTPKS Sbjct: 1621 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS 1680 Query: 1602 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ 1661 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ Sbjct: 1681 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ 1740 Query: 1662 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL 1721 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL Sbjct: 1741 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL 1800 Query: 1722 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL 1781 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL Sbjct: 1801 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL 1860 Query: 1782 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1814 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS Sbjct: 1861 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1893 >gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [Homo sapiens] Length = 969 Score = 226 bits (575), Expect = 2e-58 Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%) Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 + + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++ Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65 Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 +Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E + Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125 Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233 A E EK L L KL + K E GD L ++D+ IEEL SL ++ Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185 Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289 E L++ L EK Q+ E +S E++ + ++++ + + Q +S + Sbjct: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245 Query: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342 E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE Sbjct: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305 Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402 + AK RE L ++Q + SE T+ + ++ L+S E +L+R ++ Sbjct: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363 Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462 + ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + + Sbjct: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419 Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522 + +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L + Sbjct: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479 Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582 I +K + + + + E+K+ + + V +++ D+ + L++ S N Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534 Query: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640 + + K LE + LS QNL+ EE ++ R ++E S+ L L + Sbjct: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590 Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681 N+ +VE S L K ++ +EL Q ++ + DL Sbjct: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630 Score = 72.4 bits (176), Expect = 4e-12 Identities = 143/679 (21%), Positives = 281/679 (41%), Gaps = 125/679 (18%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115 E + +L +E L ++ LEE E TE + K T I + +S Sbjct: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242 Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175 ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + + Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294 Query: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233 E E+ + E + +L L S++ ++H + ++ + +L+ +L Sbjct: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351 Query: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289 + IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R + Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403 Query: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337 +Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E Sbjct: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461 Query: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377 NS+ +EKL AL++A ++F E+ E L E Sbjct: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521 Query: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430 L L S T + LR +++++ +LQ +E +E +E+ Sbjct: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581 Query: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475 + ++ D EVE L E+ +R + E + LLS+ NK++ Sbjct: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641 Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCS 529 E I+ L +S + ++ Q EK ++ ++++N L A L S+ I+ + + Sbjct: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701 Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIF 588 P G K+ Q S +Q+ +D T L + +E SI + +L+ + Sbjct: 702 EVTPTG---CLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVA 749 Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648 L K+L +E++ + ++E ES S S +++ EE QV+ Sbjct: 750 GLEKEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAA 795 Query: 649 SQEELKKKVSDLIQLVKEL 667 E L + + L+K+L Sbjct: 796 DMESLTRNIQIKEDLIKDL 814 Score = 47.8 bits (112), Expect = 1e-04 Identities = 82/412 (19%), Positives = 161/412 (39%), Gaps = 63/412 (15%) Query: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254 +E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L Sbjct: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113 Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314 + + K+ + E L+ ++ G Q + +Q E L + +K Sbjct: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173 Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365 + + + Q L+E++ + HLL P + E L+ +ET+ Sbjct: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230 Query: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419 S + Q++ +TE T N Q+ L E E++ ++ ++ T + L Sbjct: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286 Query: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464 ++ L ER+ E ++G A E LH S ++H + A L + Sbjct: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346 Query: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503 L + QK +R ES +K S +H Q ++++ Sbjct: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406 Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555 E LQ + + + E+R Q + + + ++QLL + +LLQ Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458 Score = 40.4 bits (93), Expect = 0.016 Identities = 83/397 (20%), Positives = 166/397 (41%), Gaps = 56/397 (14%) Query: 1403 RTLRKRLEESIKTNEKLRKQL----ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458 RTL + L + K N L+ ++ ER ++ I+ EL + S L+ + Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65 Query: 1459 NQALN--------------AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504 Q L+ A L + ++Q+E + + E L K ++ LQ E K E Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK---IQLLQEESRLAKNE 122 Query: 1505 NERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-EEVKLRQ--QLLSQNDKLLQSLRVEL 1561 R+ ++ N +L ++++ + V ++VK Q + L+Q DK ++ L L Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182 Query: 1562 KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK---SVSETPPLSGNDTDSLSC 1618 A E+L E+ R + + +E S ++ ++ + + + ET + +DS Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242 Query: 1619 DSGSSATSTPCVSRLV------TGHHL-WASKNGRHVLGLIEDYEALLKQISQGQRLLAE 1671 + T ++++ + L A ++ + G I++ LK+ + + E Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN----LKETLKSRERETE 298 Query: 1672 MDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQ 1731 Q E + T +L + H + L + SS T+ A +++ LL D Q Sbjct: 299 ELYQVIEGQNDTMAKL-REMLHQSQLGQLHSSEGTS-----PAQQQVALL-------DLQ 345 Query: 1732 CPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQ 1768 L C Q+ E+ KL + + ++E++L + + +Q Sbjct: 346 SALFCSQL-----EIQKLQRVVRQKERQLADAKQCVQ 377 Score = 36.2 bits (82), Expect = 0.30 Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%) Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249 L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S + Sbjct: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468 Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309 A E+ L++ RQ ++ A E +A D + E +++L Q + Sbjct: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513 Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359 + LE+L S M + L+ +E+ + T Q+L L E E S Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573 Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395 + E+ + + ++ E E S + QDLL Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633 Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440 +EH EI+ L + R +ES EKL + L + SE ++ G S+ + Sbjct: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693 Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494 S + +T ++ +Q +M I D K S+ R T+ ++ L Sbjct: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751 Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554 ++E ++ KEE E + K+ E + L + +EL +++ + + + L+ Sbjct: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811 Query: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576 + L+++L A E+L +E LR+ Sbjct: 812 KDLQMQLVDPEDIPAMERLTQEVLLLRE 839 Score = 34.7 bits (78), Expect = 0.87 Identities = 50/249 (20%), Positives = 102/249 (40%), Gaps = 38/249 (15%) Query: 1372 RDQKQDNETEKTSVM-VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF 1430 +D+KQ + V +NS ++ L +E + + + E ++ +L ++ R Sbjct: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122 Query: 1431 VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK--------GSRDKQKEN----- 1477 ++ + E + L+ ++ + K + + +K RDK+ E Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182 Query: 1478 ---DKLRESLSRKTVSLEHLQREYASVK-----EENERLQKEGSEKERHNQQLIQEVRCS 1529 ++L E LSR+ L HL E S++ EE + QK S + QQ + + + Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242 Query: 1530 ----------------GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573 ++L+ + E+K Q+ + D +Q+L+ LK+ E+ EE + Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 302 Query: 1574 LRDGDKYPM 1582 + +G M Sbjct: 303 VIEGQNDTM 311 >gi|157311604 phosphodiesterase 4D interacting protein isoform 1 [Homo sapiens] Length = 2346 Score = 226 bits (575), Expect = 2e-58 Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%) Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 + + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++ Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65 Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 +Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E + Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125 Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233 A E EK L L KL + K E GD L ++D+ IEEL SL ++ Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185 Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289 E L++ L EK Q+ E +S E++ + ++++ + + Q +S + Sbjct: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245 Query: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342 E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE Sbjct: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305 Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402 + AK RE L ++Q + SE T+ + ++ L+S E +L+R ++ Sbjct: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363 Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462 + ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + + Sbjct: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419 Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522 + +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L + Sbjct: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479 Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582 I +K + + + + E+K+ + + V +++ D+ + L++ S N Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534 Query: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640 + + K LE + LS QNL+ EE ++ R ++E S+ L L + Sbjct: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590 Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681 N+ +VE S L K ++ +EL Q ++ + DL Sbjct: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630 Score = 150 bits (379), Expect = 1e-35 Identities = 151/513 (29%), Positives = 245/513 (47%), Gaps = 104/513 (20%) Query: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG---STSIFASGSELHSSLT 1449 DLL EH+ EIR LR+RLEESI N++LR+QLE + + +G +++ ++ G E L Sbjct: 1842 DLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLC 1901 Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509 +E LR+ N+ L A L SR+ +E + LRE+L L+ L++E K E ++L Sbjct: 1902 NENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLL 1961 Query: 1510 KEGSEKERHNQQLIQEVRCSGQE--------LSRVQEEVKLRQQLLSQNDKLLQ------ 1555 ++ EK++ +E R S QE L +Q++ + +QQL LQ Sbjct: 1962 EDLREKQQEVLHFREE-RLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALY 2020 Query: 1556 -SLRVELKAYE--------------KLDEEHRRLRDGDKYPMESDNSFDLFDSSQ----- 1595 + + LKAY L E R LR + ++ +N L Q Sbjct: 2021 GNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGA 2080 Query: 1596 ---AVTPKSVSETPPLS----------------------GNDTDSLSCDSGSSAT---ST 1627 +++P S+++ P S G ++ +L S +S+T T Sbjct: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSET 2140 Query: 1628 PCVSR-----------LVTGHHL--------WASKNGRHVLGLIEDYEALLKQISQGQRL 1668 P ++R + T L +A+K+GRHV+G I+DY AL +QI++G+ L Sbjct: 2141 PIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLL 2200 Query: 1669 LAEMDIQTQEAPSSTSQE------LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLW 1722 + ++ + A S E LG+KG H + SS S LEE+ L + W Sbjct: 2201 VKKIVSLVRSACSFPGLEAQGTEVLGSKGIH-----ELRSSTSALHHALEESASLLTMFW 2255 Query: 1723 RVSLPEDGQCPLHCEQIGE-MKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQ----EKVI 1777 R +LP P+ ++GE + E+ +L K+ +QE+ LQ+T + L+ + +Q E+ I Sbjct: 2256 RAALPST-HIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFI 2314 Query: 1778 FDQLVVTHKILRKARGNLELRPGGAHPGTCSPS 1810 QL TH +L+KAR NLE++ A P C+P+ Sbjct: 2315 VSQLTRTHDVLKKARTNLEVKSLRALP--CTPA 2345 Score = 134 bits (336), Expect = 1e-30 Identities = 275/1354 (20%), Positives = 534/1354 (39%), Gaps = 188/1354 (13%) Query: 107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILL 166 ++E++ L+R ++++E+ L A + V+ EA E ++ KE + K Q+ Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQ-FVEAAAHESEQQKEASWKHNQE----------- 399 Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226 L K + Q EL+ + LR K +E++ + + L K++L++E Sbjct: 400 LRKALQQLQEELQNK------SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453 Query: 227 K----------LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276 + +L++ E L++ L++ A E + L +E ++ Sbjct: 454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 513 Query: 277 AQMEHQKER-----NSFEERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL 327 + +H ER +S E +Q++E LR K E+ T + +++ + Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573 Query: 328 KSKEKKVEEL-------NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALS 380 K +E +++L N E+E LSA L K + + +E+ L KE + Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATL------LCKLGPGQSEIAEELCQRLQRKERML 627 Query: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440 L S K H + I+ + Q +S +QE + + L +A E++ +R Sbjct: 628 QDLLSDR-NKQVLEHEME--IQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 684 Query: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500 + L ++ + E L + + Q T T ++DV + + D Sbjct: 685 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 744 Query: 501 LEVIQ--QNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKK----QSSDYEELI 554 L+ + + A E+LEL ++ E+ S + +++ + +++ Q++D E L Sbjct: 745 LDTVAGLEKELSNAKEELELMAK---KERESQMELSALQSMMAVQEEELQVQAADMESLT 801 Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI-- 612 + ++ ++D+ L L + + I ++ ++ LR+++ Q + +Q+ Sbjct: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861 Query: 613 ---SEIRRREEESFSLYSDQTSYLSICL--------EENNRFQVEHFSQEELKKKVSDLI 661 + R + +L +++ Y S+ E + QVE + L+ ++ ++ Sbjct: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV- 920 Query: 662 QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELL----ASKEDEDTIKIGE 717 L + L N+ + L+ +G G STE T+ + A + +K+ Sbjct: 921 -LGRSLERLNR-----LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974 Query: 718 DDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHT---------ESKISDCDGAHAPGCL 768 + + + Q+ S C + H E + ++ + + Sbjct: 975 EKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQI 1034 Query: 769 EEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL-DGKTEKTP 827 EE F ++ + + N +L LE+ EL +E GE + DG + Sbjct: 1035 EEAGFSSV-SHIRNTMLSLCLENA--------EL---------KEQMGEAMSDGWEIEED 1076 Query: 828 KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKH 887 K+KGE++ V+T + E L E + ++ LK+A + L+ Sbjct: 1077 KEKGEVM--VETVVTKEGLSESSLQAEFRKLQGK------LKNAHNIINLLKEQLVLSSK 1128 Query: 888 EATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRS 947 E + E ++ + E L G PG E + P S Sbjct: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQH--------QEEGNVTVRPFPRPQSLD 1180 Query: 948 LGNMYRLPATQ------------EVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAV 995 LG + + A Q + L L+ +L + K + L +KL+L+EA Sbjct: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240 Query: 996 MEGRPTP---DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE 1052 + + + +L + V + + + + + + E + ++ S E + Sbjct: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300 Query: 1053 ICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY- 1111 + + C E + L+S S+ + +G + + +E Sbjct: 1301 NSLKEMVLMEGLCSEQGRR-------GSTLASSSERKPLENQLGKQEEFRVYGKSENILV 1353 Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE--------GAQDGLSKPKNG 1163 L++ I DL+ +L+ I L+ + E G +G S P + Sbjct: 1354 LRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEG-SSPHSV 1412 Query: 1164 SDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223 D +E S Y +P + + LE+L Q++ + E +L K L +L Sbjct: 1413 PDEDEGWLSDGTGAFY----------SPGLQAKKDLESLIQRVSQLEAQLPKN-GLEEKL 1461 Query: 1224 FSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEE 1283 E+ + P +YDSL+Q QARELS RQ+I++G GIC + +H +K+FE+ Sbjct: 1462 AEELRSAS------WPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED 1515 Query: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEKL-EKLFLNG-----KSVGVE---MNTQNELME 1334 LL+++D+DY + + F+EQL Q ++L E+L KL G+E + EL E Sbjct: 1516 LLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQE 1575 Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368 + + + L S PS+SHALSD S S Sbjct: 1576 KEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSS 1609 Score = 72.4 bits (176), Expect = 4e-12 Identities = 143/679 (21%), Positives = 281/679 (41%), Gaps = 125/679 (18%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115 E + +L +E L ++ LEE E TE + K T I + +S Sbjct: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242 Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175 ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + + Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294 Query: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233 E E+ + E + +L L S++ ++H + ++ + +L+ +L Sbjct: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351 Query: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289 + IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R + Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403 Query: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337 +Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E Sbjct: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461 Query: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377 NS+ +EKL AL++A ++F E+ E L E Sbjct: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521 Query: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430 L L S T + LR +++++ +LQ +E +E +E+ Sbjct: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581 Query: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475 + ++ D EVE L E+ +R + E + LLS+ NK++ Sbjct: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641 Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCS 529 E I+ L +S + ++ Q EK ++ ++++N L A L S+ I+ + + Sbjct: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701 Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIF 588 P G K+ Q S +Q+ +D T L + +E SI + +L+ + Sbjct: 702 EVTPTG---CLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVA 749 Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648 L K+L +E++ + ++E ES S S +++ EE QV+ Sbjct: 750 GLEKEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAA 795 Query: 649 SQEELKKKVSDLIQLVKEL 667 E L + + L+K+L Sbjct: 796 DMESLTRNIQIKEDLIKDL 814 Score = 47.8 bits (112), Expect = 1e-04 Identities = 82/412 (19%), Positives = 161/412 (39%), Gaps = 63/412 (15%) Query: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254 +E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L Sbjct: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113 Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314 + + K+ + E L+ ++ G Q + +Q E L + +K Sbjct: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173 Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365 + + + Q L+E++ + HLL P + E L+ +ET+ Sbjct: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230 Query: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419 S + Q++ +TE T N Q+ L E E++ ++ ++ T + L Sbjct: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286 Query: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464 ++ L ER+ E ++G A E LH S ++H + A L + Sbjct: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346 Query: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503 L + QK +R ES +K S +H Q ++++ Sbjct: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406 Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555 E LQ + + + E+R Q + + + ++QLL + +LLQ Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458 Score = 45.4 bits (106), Expect = 5e-04 Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 37/236 (15%) Query: 379 LSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRD 438 L++ R + T + + L SI ++ E L+++ RL+ L RE S+ Sbjct: 1876 LTSTARGRGSTSNFYSQGLE-SIPQLCNENRVLREDNRRLQAQLSHVSREHSQ------- 1927 Query: 439 LRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498 E E LR E + +R S L E K+L +Q+ + L E +K + F E Sbjct: 1928 ---ETESLR------EALLSSR--SHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE 1976 Query: 499 KDLEVIQQNCYLMAAEDLELRSE-GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVL 557 + L +Q+N D L+ + L+ ++C +Q +F + + YE L Sbjct: 1977 ERLS-LQEN-------DSRLQHKLVLLQQQCEEKQQ-----LFESLQSELQIYEALYGNS 2023 Query: 558 KKEQDIYT-HLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612 KK Y+ + S +++L AE+ ALR QLEQ + LR L++Q+ Sbjct: 2024 KKGLKAYSLDACHQIPLSSDLSHLVAEVR---ALRGQLEQSIQGNNCLRLQLQQQL 2076 Score = 40.4 bits (93), Expect = 0.016 Identities = 83/397 (20%), Positives = 166/397 (41%), Gaps = 56/397 (14%) Query: 1403 RTLRKRLEESIKTNEKLRKQL----ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458 RTL + L + K N L+ ++ ER ++ I+ EL + S L+ + Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65 Query: 1459 NQALN--------------AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504 Q L+ A L + ++Q+E + + E L K ++ LQ E K E Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK---IQLLQEESRLAKNE 122 Query: 1505 NERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-EEVKLRQ--QLLSQNDKLLQSLRVEL 1561 R+ ++ N +L ++++ + V ++VK Q + L+Q DK ++ L L Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182 Query: 1562 KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK---SVSETPPLSGNDTDSLSC 1618 A E+L E+ R + + +E S ++ ++ + + + ET + +DS Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242 Query: 1619 DSGSSATSTPCVSRLV------TGHHL-WASKNGRHVLGLIEDYEALLKQISQGQRLLAE 1671 + T ++++ + L A ++ + G I++ LK+ + + E Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN----LKETLKSRERETE 298 Query: 1672 MDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQ 1731 Q E + T +L + H + L + SS T+ A +++ LL D Q Sbjct: 299 ELYQVIEGQNDTMAKL-REMLHQSQLGQLHSSEGTS-----PAQQQVALL-------DLQ 345 Query: 1732 CPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQ 1768 L C Q+ E+ KL + + ++E++L + + +Q Sbjct: 346 SALFCSQL-----EIQKLQRVVRQKERQLADAKQCVQ 377 Score = 36.2 bits (82), Expect = 0.30 Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%) Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249 L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S + Sbjct: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468 Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309 A E+ L++ RQ ++ A E +A D + E +++L Q + Sbjct: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513 Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359 + LE+L S M + L+ +E+ + T Q+L L E E S Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573 Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395 + E+ + + ++ E E S + QDLL Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633 Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440 +EH EI+ L + R +ES EKL + L + SE ++ G S+ + Sbjct: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693 Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494 S + +T ++ +Q +M I D K S+ R T+ ++ L Sbjct: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751 Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554 ++E ++ KEE E + K+ E + L + +EL +++ + + + L+ Sbjct: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811 Query: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576 + L+++L A E+L +E LR+ Sbjct: 812 KDLQMQLVDPEDIPAMERLTQEVLLLRE 839 Score = 35.4 bits (80), Expect = 0.51 Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 14/133 (10%) Query: 278 QMEHQKERNSFEERIQALEEDLREKEREI---ATEKKNSLKRDKAIQG----LTMALKSK 330 ++EHQK Q L EDLREK++E+ E+ + + D +Q L + K Sbjct: 1949 ELEHQKVER------QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK 2002 Query: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390 ++ E L SE++ A + +++ L KA + + + LS A ALR Q Sbjct: 2003 QQLFESLQSELQIYEALYGNSKKGL-KAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQS 2061 Query: 391 STENHRLRRSIKK 403 N+ LR +++ Sbjct: 2062 IQGNNCLRLQLQQ 2074 Score = 34.7 bits (78), Expect = 0.87 Identities = 50/249 (20%), Positives = 102/249 (40%), Gaps = 38/249 (15%) Query: 1372 RDQKQDNETEKTSVM-VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF 1430 +D+KQ + V +NS ++ L +E + + + E ++ +L ++ R Sbjct: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122 Query: 1431 VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK--------GSRDKQKEN----- 1477 ++ + E + L+ ++ + K + + +K RDK+ E Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182 Query: 1478 ---DKLRESLSRKTVSLEHLQREYASVK-----EENERLQKEGSEKERHNQQLIQEVRCS 1529 ++L E LSR+ L HL E S++ EE + QK S + QQ + + + Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242 Query: 1530 ----------------GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573 ++L+ + E+K Q+ + D +Q+L+ LK+ E+ EE + Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 302 Query: 1574 LRDGDKYPM 1582 + +G M Sbjct: 303 VIEGQNDTM 311 Score = 34.7 bits (78), Expect = 0.87 Identities = 60/282 (21%), Positives = 117/282 (41%), Gaps = 35/282 (12%) Query: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAP--------- 266 L E L + L+ S+ + L + L+ + A + S+ +GL + P Sbjct: 1848 LGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVL 1907 Query: 267 REEKER---ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323 RE+ R + EH +E S E + + L+E E+E+ +K ++R + ++ L Sbjct: 1908 REDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQK---VERQQLLEDL 1964 Query: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAR-----EALQKAQTQEFQGSEDYETALSGKEA 378 +EK+ E L+ E+LS +R LQ+ ++ Q E ++ L EA Sbjct: 1965 ------REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018 Query: 379 LSAALRSQNLTKSTENHRLRRSIK-KITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437 L N K + + L + ++ +LS L E L LE++ + +C Sbjct: 2019 LYG-----NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ---GNNCLRL 2070 Query: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479 L+ ++E + + ++ + + NK+L Q+ + Sbjct: 2071 QLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV 2112 Score = 33.5 bits (75), Expect = 1.9 Identities = 37/149 (24%), Positives = 69/149 (46%), Gaps = 16/149 (10%) Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD-QTSYLSIC-- 636 L+ L +I LR++LE+ + LR+ LE +++ R + + YS S +C Sbjct: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903 Query: 637 ---LEENNR---FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690 L E+NR Q+ H S+E ++ S L + L + HL++ +L + Sbjct: 1904 NRVLREDNRRLQAQLSHVSREHSQETES----LREALLSSRSHLQELEKELEHQKVERQQ 1959 Query: 691 FPDRLASTEQTELLASKEDEDTIKIGEDD 719 + L +Q E+L +E+ + + E+D Sbjct: 1960 LLEDLREKQQ-EVLHFREER--LSLQEND 1985 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 134 bits (338), Expect = 6e-31 Identities = 314/1537 (20%), Positives = 619/1537 (40%), Gaps = 240/1537 (15%) Query: 140 SEIQRVKEDARKKVQQVEDLLTKR----ILLLEKDVTAAQAELEKAFAGTETEKALRLRL 195 SE+ ++ D V E L T++ + L EK+ LE+ +T+K ++L Sbjct: 498 SELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALER-----KTKKDQEMQL 552 Query: 196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 ++S +K + + + ++L+ L SK ++ L+E++ Q+ E + Sbjct: 553 IHEISNLKNL----------VKHAEVYNQDLENELSSK---VELLREKEDQIKKLQEYID 599 Query: 256 SGELRGL----------CAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKERE 305 S +L + P++ K+ +A + +R S R + LE L+EK +E Sbjct: 600 SQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE--LKEKMKE 657 Query: 306 IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQG 365 +AT K + + IQ L++K+K +L E++ K + ++ Sbjct: 658 LATTYK---QMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714 Query: 366 SEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEA 425 + + E ++ + + L K E + R + EL L E ERL K++++ Sbjct: 715 NLELEGKITDLQ--------KELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766 Query: 426 HREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--------LSESNKKLHNQE- 476 E + + +E +KL +EV +E ++ + + ++SN K +QE Sbjct: 767 SEE-------LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819 Query: 477 QVIKHLTESTNQKDVLLQKFNEK-DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPG 535 Q K L QK ++ + NE+ + E++ + A+ + L TE Q Sbjct: 820 QNFKTLHMDFEQKYKMVLEENERMNQEIVNLS---KEAQKFDSSLGALKTELSYKTQELQ 876 Query: 536 SKTIFSKE--------KKQSSDYEELIQVLKKEQDIYTHL-------VKSL-QESDSINN 579 KT +E K+Q + + +Q +++E+ + T VK+L QE D + Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936 Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI----SEIRRREEESFSLYSDQTSYLS- 634 LQ L R QL+ D+ N+ +EQ+ +++ +E +L S + +S Sbjct: 937 LQESLQ---IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993 Query: 635 -ICLEENNRFQVEHFSQEELK-KKVSDL----IQLVKELYTDNQHLK--KTIFDLSCMGF 686 + +EEN + F Q+ + K DL Q + DN+ ++ + IF L Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ--- 1050 Query: 687 QGNGFPDRLAST--EQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGC 744 + N L S E+ +L ++ + I +E+ L D+ +Q + ++ + Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110 Query: 745 KNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLL 804 K G L T ++++ + EK+ L E + LL V E+ Sbjct: 1111 KEGELSRTCDRLAEVEEK------------------LKEKSQQLQEKQQQLLNVQEEMSE 1152 Query: 805 GQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVP 864 Q + E E L K + E + Q KL+ + VK+ Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQ-----------KLNENYEEVKSITKE 1201 Query: 865 KVGLKDASVQTVATEGDLLRF---KHEATR-EAWEEKPINTALSAEHRP---ENLHGVPG 917 + LK+ ++ TE D LR + EAT + EE I EH+ E V Sbjct: 1202 RKVLKELQ-KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260 Query: 918 WQAALLSLPGITNREAK-KSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELK 976 A +++ + K + +P+L + L N+ + TQE + +L ++L Q K Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL--ELLTEQSTTK 1318 Query: 977 EFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRD 1036 + T + ++L L E E + K+L + + K IK V D Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQ-EEIKSLTKERDNL-----------KTIKEALEVKHD 1366 Query: 1037 KEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMG 1096 + + ++ +I + ++ KE + S K ++ + Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNM---KEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423 Query: 1097 TDQSESINTS-NETEYLKQKIHDLETELEGYQNFIFQLQ--------KHSQCSEAIITVL 1147 S+ + S +E + + ++ DL+ E Q+ QL+ KH + E + Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483 Query: 1148 CGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLE 1207 C + ++ +++ + +E S++ + LE + +L+ Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTI---------------------QKQLEAINDKLQ 1522 Query: 1208 EQEYKL-QKEQNLNMQLFSEIHNLQNKFRDLSPPR--YDSLVQSQARELSLQRQQIKDGH 1264 + ++ +KE+ N++ SE+ N+ + R DS +QS ++ ++++ Sbjct: 1523 NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE-- 1580 Query: 1265 GICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ-CAELLEKLEKLFLNGKSVG 1323 S++ + MIK EE+ + + + +E + A++ E EK + K Sbjct: 1581 -----SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635 Query: 1324 V---------------EMNTQNELMERIEEDNLTYQHLLPESPEP--SASHALSDYETSE 1366 V + TQ +E IE +N+ +L E+ E S + D + E Sbjct: 1636 VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVE 1695 Query: 1367 KSF-FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425 ++ RDQ ++N E + ++DL E +E++ + L+E +T +KLR + Sbjct: 1696 ETLKVERDQLKENLRE-------TITRDL--EKQEELKIVHMHLKEHQETIDKLRGIVSE 1746 Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485 + +E + S L + LR + L +++Q+ DKLR +S Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHL--------KEQQETIDKLRGIVS 1798 Query: 1486 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ 1545 KT L ++Q++ ++ N +LQ++ E + + QLI + + +V E +L++Q Sbjct: 1799 EKTDKLSNMQKD---LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855 Query: 1546 LLSQNDKL----LQSLRVELKAYEKLDEEHRRLRDGD 1578 + Q+ L +++L + K +E L+E +++ D Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1892 Score = 125 bits (314), Expect = 4e-28 Identities = 300/1590 (18%), Positives = 642/1590 (40%), Gaps = 198/1590 (12%) Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156 +H N +L+ E+ S L+E+E + K + ++S +++ +K D ++ + Sbjct: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS------QKLENIKMDLSYSLESI 617 Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK---KMHEGDLAM- 212 ED + L + + A A+ E AF +E L L+ K+ E+ K E D+ + Sbjct: 618 EDPKQMKQTLFDAETVALDAKRESAFLRSEN-----LELKEKMKELATTYKQMENDIQLY 672 Query: 213 ALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER 272 L+ K ++ +L+ L+S I L P + + + EL G ++E + Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV-PKDLLCNLELEGKITDLQKELNK 731 Query: 273 ETEAAQMEHQK-----ERNSFEERIQALEEDLREKERE--IATEKKNSLKRDKAIQGLTM 325 E E + ++ E S ++ L +++++K E I T +K+ L + Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE-------- 783 Query: 326 ALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRS 385 + KE +V+ L EI K A ++ K+ QEFQ + K + Sbjct: 784 -VVHKESRVQGLLEEIGKTKDDLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMVLE--- 838 Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 EN R+ QE+ +L +E ++ + L E S +++ EV++ Sbjct: 839 -------ENERMN-------QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884 Query: 446 LRNEVNEREKAMENRYKSLLSESNKK---LHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502 NE+ + ++ +ENR +L + +K +Q ++ + T +KD L Q +E Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944 Query: 503 ---------------VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547 + Q A E L+ E + T K + + ++ Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET 1004 Query: 548 SD-YEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA-------LRKQLEQDVL 599 D +++ + + K+QD+ ++L N + + KIF+ L++ LE + Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA 1064 Query: 600 SYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSD 659 + L+ L+E I +EE L + I +E N + ++++ Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE 1124 Query: 660 LIQLVKE----LYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKI 715 + + +KE L Q L ++S M + N + + EL + + +++ Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184 Query: 716 GEDDEINFLSDQHLQQSNEIMKDLSKG-----GCKNGYLRHTES---------KISDCDG 761 + N+ + + + +++K+L K GY+R E+ KI+ Sbjct: 1185 AQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHL 1244 Query: 762 AHAPGCLEE--GAFINLLAPLFN----EKATLLLESRPDLLKVVRELLLGQLFLTEQEVS 815 ++E + A + N EK+ L+ +L +ELL ++E + + Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304 Query: 816 GEHLDGKTEK------TPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVK----AGEVP 864 L+ TE+ T + E+ F + +E+K L+ E +K A EV Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364 Query: 865 KVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLS 924 LK+ +T+A + + K E + E+ T + +E + +ALL Sbjct: 1365 HDQLKEHIRETLAKIQE-SQSKQEQSLNMKEKDNETTKIVSE-----MEQFKPKDSALLR 1418 Query: 925 LP----GITNR-EAKKSRLPILIKPSRSLGNMYRLPATQ-----EVVTQLQSQILELQGE 974 + G++ R + + + K L + + ++ E + ++ ++ LE + E Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478 Query: 975 LKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVW 1034 LK C K+ + + + + T T+ + Q+ E ++ Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE---------IY 1529 Query: 1035 RDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENP-EDVLSPTSVATYLSSKSQPSAKVS 1093 +E + +Q S E+ ++ K++ + + S T +SQ ++ Sbjct: 1530 EKEEQFNIKQIS-EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588 Query: 1094 VMGTDQSESINTS--NETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE 1151 + ++ + + + E + LK+ ++ +++ Q +Q K + +E +C E Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET-QEKMCEIE 1647 Query: 1152 GAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR-VLENLKQQLEEQE 1210 ++ K + E L Q+ + ++++ + + E D R V E LK + ++ + Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILH-ENLEEMRSVTKERDDLRSVEETLKVERDQLK 1706 Query: 1211 YKLQK--EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICV 1268 L++ ++L Q +I ++ K + + +V + E+S ++ + Sbjct: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL-------- 1758 Query: 1269 ISRQHMNTMIKAFEELLQAS-DVDYCVAEGFQEQLNQCAELL-EKLEKLFLNGKSVGVEM 1326 +H N +KA + +Q + + + QE +++ ++ EK +KL K + Sbjct: 1759 ---EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL---E 1812 Query: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386 N+ +L E+I+E L+ + K + QK+ +E E+ Sbjct: 1813 NSNAKLQEKIQELKANEHQLI-----------------TLKKDVNETQKKVSEMEQLKKQ 1855 Query: 1387 VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHS 1446 + S L I+ + L ++L E+++ + + K ER V+ + + +L Sbjct: 1856 IKDQSLTLSKLEIENL-NLAQKLHENLEEMKSVMK--ERDNLRRVEETLKL--ERDQLKE 1910 Query: 1447 SL-TSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505 SL ++ L Q + A ++ S++ ++ DKLRE +S KT+ + +Q++ K+E Sbjct: 1911 SLQETKARDLEIQQELKTARML--SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDEL 1968 Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE-EVKLRQQLLSQNDKLLQSLRVELKAY 1564 ++ +E +KE ++ ++V S ++++ +++ + + Q LS + + ++ K + Sbjct: 1969 QKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028 Query: 1565 EKLDE---------EHRRLRDGDKYPMESD 1585 E L+E E RR+++ K ME D Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLK--MERD 2056 Score = 102 bits (255), Expect = 3e-21 Identities = 338/1700 (19%), Positives = 677/1700 (39%), Gaps = 264/1700 (15%) Query: 56 RARNMKDFENQITELKK--ENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESL 113 + R +++ N++ +LK+ EN + L+ E+ + E T KT + K +++ L Sbjct: 878 KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937 Query: 114 KRELQ-EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK------RILL 166 + LQ ER+QL V + +++ E ++ + + L +K R L Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQETINTLKSKISEEVSRNLH 996 Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHE---GDLAMALVLDEKDRLI 223 +E++ + E ++ G + ++ L + L+ K +E + ++ EK+ L Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056 Query: 224 EELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH-- 281 + L+ + KE L LKE +M ++ ELR L +K++E A + H Sbjct: 1057 QMLESVIAEKEQLKTDLKEN-IEMTIENQE----ELRLL--GDELKKQQEIVAQEKNHAI 1109 Query: 282 --QKERNSFEERIQALEEDLREKEREIATEKKNSL----------KRDKAIQGLTMALKS 329 + E + +R+ +EE L+EK +++ +++ L K+ I+ L LK+ Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKN 1169 Query: 330 KEKKVEELNSEIEKLSA----------AFAKAREALQKAQTQEFQGSEDY---------E 370 KE +E + +E +L+ + K R+ L++ Q + F+ D+ Sbjct: 1170 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ-KSFETERDHLRGYIREIEA 1228 Query: 371 TALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQEL---SDLQQERERLEKDLEEAHR 427 T L KE L A + T + LRRS+ + T ++ DL++ +L++++ H Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDE-LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287 Query: 428 EKS-----KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHL 482 E+ K ++ NE+E L + ++ R + N+K ++ IK L Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347 Query: 483 T----------ESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQ- 531 T E+ K L++ + L IQ++ + L ++ + T K S+ Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES-QSKQEQSLNMKEKDNETTKIVSEM 1406 Query: 532 ---QPPGSKTI------FSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582 +P S + K+ ++E+ V K++ D+ ++ + +S+S + L+ Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL--QRLQEVLQSES-DQLKE 1463 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR-RREEESFSLYSDQTSYLSICLEENN 641 + +I A + E+++ K EE I+E+R E+ + + Q +I + N Sbjct: 1464 NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN 1523 Query: 642 RFQVEHFSQEELK-KKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700 + Q + +E+ K++S++ + V EL +H K L + + +RL +++ Sbjct: 1524 KIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQE 1583 Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKN-GYLRHT---ESKI 756 + KE E+ ++ E +I DQ + + EI+ + + K +L+ T E++ Sbjct: 1584 EIQIMIKEKEEMKRVQEALQIE--RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641 Query: 757 SDCDGAHAPGCLE---------EGAFINLLAPLFN--EKATLLLESRPDL------LKVV 799 C+ H E E I L L E+ + + R DL LKV Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701 Query: 800 RELLLGQLFLT-------EQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLS 852 R+ L L T ++E+ H+ K + K + +TN S +L+ S Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761 Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENL 912 +A +KA +D +Q + LR H +E E + L Sbjct: 1762 NDA--LKA--------QDLKIQ------EELRIAHMHLKEQQE------------TIDKL 1793 Query: 913 HGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQ 972 G+ + LS ++ + S + K N ++L ++ V + Q ++ E++ Sbjct: 1794 RGIVSEKTDKLS---NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850 Query: 973 GELKEFK----TCNK----------QLHQKLILAEAVMEGRPT---PDKTLLNAQPPVGA 1015 K+ K T +K +LH+ L ++VM+ R ++TL + + Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910 Query: 1016 AYQDSPGE----QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071 + Q++ Q+ +KT + ++ + D+ R + I D L K+ Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE--- 1967 Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTS----NETEYLKQKIHDLETELEGYQ 1127 L K Q K + E +N S NE E LK++ ++ + Sbjct: 1968 ----------LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017 Query: 1128 NFIFQLQK--HSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF-SSLHQVRYVKHVK 1184 FQL K H E I +D L + K E F ++L ++ + + Sbjct: 2018 MDNFQLTKKLHESLEEIRIVA-----KERDELRRIKESLKMERDQFIATLREM--IARDR 2070 Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244 + PE R+L + +Q L E L+++ + +L + + + L+ D Sbjct: 2071 QNHQVKPE---KRLLSDGQQHLTE---SLREKCSRIKELLKRYSEMDDHYECLNRLSLDL 2124 Query: 1245 LVQSQ-ARELSLQRQQIKDGHGICVISRQHMNTMIKA-------FEELLQASDVDYCVAE 1296 + + +ELS+ ++K + + +H+ + A F +++ Sbjct: 2125 EKEIEFQKELSM---RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181 Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSAS 1356 +E+ + E + K E F++ E+ Q EL+ +I QHL + P S Sbjct: 2182 KIKEEQH---ESINKFEMDFID------EVEKQKELLIKI-------QHLQQDCDVP--S 2223 Query: 1357 HALSDYETSEK---------SFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRK 1407 L D + ++ FS + +TE V+ N +E R + Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE 2283 Query: 1408 RLEESI-KTNEKLRK----------QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR 1456 +L+ I K N+++ + + + +EF + S +I + SL + L Sbjct: 2284 KLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF 2343 Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSL--EHLQREYASVKEENERLQKEGSE 1514 K Q L L G++ D ++ + L E ++ S+ E E Sbjct: 2344 KNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKE----SAMH 2399 Query: 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL----KAY-EKLDE 1569 KE ++ +E+ + ++++Q +V + L + + +Q L+ ++ K Y E++++ Sbjct: 2400 KESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459 Query: 1570 EHRRLRDGDKYPMESDNSFD 1589 +L D M++ F+ Sbjct: 2460 LKMKLVKIDLEKMKNAKEFE 2479 Score = 100 bits (248), Expect = 2e-20 Identities = 157/775 (20%), Positives = 329/775 (42%), Gaps = 112/775 (14%) Query: 44 LPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTN 103 L + E ++ NMK+ +N+ T++ E K + L R++ E G ++ + +++ Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESH 1434 Query: 104 IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163 E+K V K +LQ +++L S ++ + +KE K ++ E+L Sbjct: 1435 DEMK-SVAKEKDDLQRLQEVLQSESDQLK----------ENIKEIVAKHLETEEELKVAH 1483 Query: 164 ILLLEKDVTAAQAELEKAFAGTETE------KALRLRLESKLSEM-KKMHEGDLAMALVL 216 L E++ T + + + TE +A+ +L++K+ E+ +K + ++ + Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543 Query: 217 DEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276 EK +++ K K+K++ +Q ++ + ++ R ++ +E Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELT-----------------NRLQESQEEIQ 1586 Query: 277 AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE 336 ++ ++E +E +Q + L+E +EI + K S +++ +T +++EK Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM--- 1643 Query: 337 LNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAA---LRSQNLTKSTE 393 EIE L F + L+ +T+ + ++ L +++ LRS T E Sbjct: 1644 --CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701 Query: 394 NHRLRRSIKK-ITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE 452 +L+ ++++ IT++L + Q+E + + L+E H+E TI LR V + NE++ Sbjct: 1702 RDQLKENLRETITRDL-EKQEELKIVHMHLKE-HQE------TIDKLRGIVSEKTNEISN 1753 Query: 453 REKAMENRYKSLLSESNK----------KLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502 +K +E+ +L ++ K L Q++ I L ++K L +KDLE Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM-QKDLE 1812 Query: 503 VIQQNCYLM-AAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQ 561 N L ++L+ LIT K + + + KKQ D + L+ E Sbjct: 1813 --NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870 Query: 562 -DIYTHLVKSLQESDSI------------------NNLQAELNKIFALRKQLEQDVLSYQ 602 ++ L ++L+E S+ + L+ L + A +++Q++ + + Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930 Query: 603 NLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELK-------- 654 L K +E + ++R + E SD L +E + +++ ++EL+ Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK-KIQELQKKELQLLRVKEDV 1989 Query: 655 ----KKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL-ASTEQTELLASKED 709 KK++++ QL K+ N ++ D FQ +L S E+ ++A + D Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMD----NFQ---LTKKLHESLEEIRIVAKERD 2042 Query: 710 E-----DTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759 E +++K+ D I L + + K +G TES C Sbjct: 2043 ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097 Score = 68.9 bits (167), Expect = 4e-11 Identities = 157/756 (20%), Positives = 296/756 (39%), Gaps = 160/756 (21%) Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117 + +KD +++L+ EN NL +++ E M+ +++ + LK+E + LK L Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK-ERDNLRRVEETLKLERDQLKESL 1912 Query: 118 QE---REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAA 174 QE R+ + + K L++ + +++E +K Q+ D+ +KD+ + Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI--------QKDLDKS 1964 Query: 175 QAELEKAFAGTETEKALRLRLES-------KLSEM------------------------- 202 + EL+K + ++ LR++ K++EM Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024 Query: 203 KKMHEGDLAMALVLDEKDRLIEELKLSLK-SKEALIQCLKE-----EKSQMACPDENVSS 256 KK+HE + +V E+D L +K SLK ++ I L+E ++ P++ + S Sbjct: 2025 KKLHESLEEIRIVAKERDEL-RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083 Query: 257 GELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK- 315 + L + RE+ R E ++ E + E + L DL E+EI +K+ S++ Sbjct: 2084 DGQQHLTESLREKCSRIKEL--LKRYSEMDDHYECLNRLSLDL---EKEIEFQKELSMRV 2138 Query: 316 ---------RDKAIQGLTMA----------------------LKSKEKKVEELNS----- 339 + K I+ L A K KE++ E +N Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198 Query: 340 --EIEKLSAAFAKAREALQKAQTQEFQGSE---DYETALSGKEALSAALRSQNLTKSTEN 394 E+EK K + Q + + + L +E L S+ + TE Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEF 2258 Query: 395 HRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDL-RNEVEKLRNEVNER 453 ++ + K++TQ L + R +EK L+ ++++ C + + N + + NE E Sbjct: 2259 QQVLSNRKEMTQFLEEWLNTRFDIEK-LKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2317 Query: 454 E-------KAMENRYKSLLSESNKKLHNQEQVIK-------------------HLTESTN 487 E K E KSL E N+KL Q +K H+T Sbjct: 2318 EERSATISKEWEQDLKSL-KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT 2376 Query: 488 QKDVLLQKFNE--------------KDLEVIQQNCYLMAAEDLELRSEGLITE--KCSSQ 531 Q + +K E K+ ++I+ L D+ + + + E KC + Sbjct: 2377 Q--LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434 Query: 532 QPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVK-SLQESDSINNLQAELNKIFA- 589 + + K + Y+E I+ LK + LVK L++ + + E++ A Sbjct: 2435 TKETIQVLQDKVALGAKPYKEEIEDLKMK------LVKIDLEKMKNAKEFEKEISATKAT 2488 Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQV---E 646 + Q E L +NLR++ + Q + + + T + +N + + E Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSE 2548 Query: 647 HFSQEE----LKKKVSDLIQLVKELYTDNQHLKKTI 678 H E+ LK++ LI+ EL ++NQHL + Sbjct: 2549 HIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584 Score = 53.9 bits (128), Expect = 1e-06 Identities = 105/469 (22%), Positives = 189/469 (40%), Gaps = 87/469 (18%) Query: 270 KERETEAAQMEHQKERNSFEERIQALEED-----LREKE--REIATEKKNSLKR---DKA 319 K E ++ Q E S E R QA+E+D L EK+ +++ EK +L R + Sbjct: 346 KRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSS 405 Query: 320 IQGLTMALKSKEKK-----------------------VEELNSEIEKLSAAFAKAREALQ 356 L LK+K K+ + ++ KLS + + Sbjct: 406 SLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESV 465 Query: 357 KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE 416 +++ F + D + + A + L +N+ +E + LR + + L+ E+E Sbjct: 466 CSESDVFSNTLDTLSEIEWNPA-TKLLNQENI--ESELNSLRADYDNLVLDYEQLRTEKE 522 Query: 417 RLEKDLE--------EAHREKSKGDCTIRDLRNEVEKLRNEVNERE---KAMENRYKS-- 463 +E L+ EA K+K D ++ L +E+ L+N V E + +EN S Sbjct: 523 EMELKLKEKNDLDEFEALERKTKKDQEMQ-LIHEISNLKNLVKHAEVYNQDLENELSSKV 581 Query: 464 -LLSE------------SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD---LEVIQQN 507 LL E ++KL N + + + ES + Q + + L+ +++ Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641 Query: 508 CYLMAAEDLELR---SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIY 564 +L +E+LEL+ E T K ++ +KK D E+ +Q E Sbjct: 642 AFL-RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700 Query: 565 THLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---------KTLEEQISEI 615 T L+ D + NL+ E KI L+K+L ++V + LR K+L ++ + Sbjct: 701 TSLIDGKVPKDLLCNLELE-GKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERL 759 Query: 616 RR----REEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660 R+ + EE + S++ S + + +R Q EE+ K DL Sbjct: 760 RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ---GLLEEIGKTKDDL 805 Score = 40.8 bits (94), Expect = 0.012 Identities = 88/419 (21%), Positives = 169/419 (40%), Gaps = 96/419 (22%) Query: 347 AFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQ 406 +F + ALQ A T ++ + Y +S EAL R + + L++ +++++ Sbjct: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMD-------LKKQLEEVSL 364 Query: 407 ELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLS 466 E E+++L + LEE +DL ++K++NE E M SL Sbjct: 365 ETRAQAMEKDQLAQLLEE------------KDL---LQKVQNEKIENLTRMLVTSSSLTL 409 Query: 467 ESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE 526 + K + +V L + K+ N D I N IT Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKN-----SNYADQFNIPTN----------------ITT 448 Query: 527 KCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESD--------SIN 578 K K + E+ + + E D++++ + +L E + + Sbjct: 449 K--------------THKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQE 494 Query: 579 NLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRR----EEESFSLYSDQTSYLS 634 N+++ELN +LR + VL Y+ LR EE +++ + E E+ + + + Sbjct: 495 NIESELN---SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ 551 Query: 635 ICLEENN-RFQVEHFS--QEELKKKVSDLIQLVKEL---------YTDNQHLKKTIFDLS 682 + E +N + V+H ++L+ ++S ++L++E Y D+Q L+ DLS Sbjct: 552 LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611 Query: 683 CMGFQGNGFPDRLASTEQ-TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS 740 L S E ++ + D +T+ + E FL ++L + E MK+L+ Sbjct: 612 Y----------SLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKEKMKELA 659 Score = 38.9 bits (89), Expect = 0.046 Identities = 68/310 (21%), Positives = 128/310 (41%), Gaps = 58/310 (18%) Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320 K+ IC ++ N +I E + + +++ +++ L L EK EKLF N + Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS---LKEKNEKLFKNYQ 2347 Query: 1321 SV------GVEMNTQNE--------------LMERIEEDNLTYQHLLPESPEPSASHALS 1360 ++ G ++N + E+I E ++ L E+ E SA H S Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE----LENSLHEAKE-SAMHKES 2402 Query: 1361 DYETSEKSF------FSRDQKQDNET----EKTSVMVNSFSQDLLM---EHIQEIRTLRK 1407 +K ++ Q + +E+ EKT + + + + +EI L+ Sbjct: 2403 KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKM 2462 Query: 1408 RLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLI 1467 +L + K K+ E++ + + + E+ L LR+ QA + +I Sbjct: 2463 KLVKIDLEKMKNAKEFEKE----ISATKATVEYQKEVIRLLREN---LRRSQQAQDTSVI 2515 Query: 1468 KGSRDKQKENDKLR----ESLSRKTVSL----EH--LQREYASVKEENERLQKEGSEKER 1517 D Q N L + + T +L EH L++E + +K++NE+L K+ +E Sbjct: 2516 SEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLS 2575 Query: 1518 HNQQLIQEVR 1527 +NQ L EV+ Sbjct: 2576 NNQHLSNEVK 2585 Score = 38.5 bits (88), Expect = 0.060 Identities = 94/457 (20%), Positives = 181/457 (39%), Gaps = 92/457 (20%) Query: 58 RNMKDFENQITELKKENFNL--KLRIYFLEE------------RMQQEFHGPTEHI--YK 101 + +K + +T++K+E K + F++E +QQ+ P+ + K Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK 2230 Query: 102 TNIELKVEVESLKRELQERE---------QLLIKASKAVESLAEAGGS--EIQRVKEDAR 150 N + + +E + ++ E E Q+L + + L E + +I+++K + Sbjct: 2231 LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQ 2290 Query: 151 K---KVQQVEDLLTKRILLL------------------EKDVTAAQAELEKAFAGTETEK 189 K ++ QV + RI+ + E+D+ + + + EK F +T K Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLK 2350 Query: 190 ---ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSL-KSKEALIQCLKEEKS 245 A ++ + K H A L ++ I EL+ SL ++KE+ + KE K Sbjct: 2351 TSLASGAQVNPTTQDNKNPHVTSRATQLTTEK----IRELENSLHEAKESAMH--KESKI 2404 Query: 246 QMACPDENVSSGELRGLCAAPRE-----EKERET-EAAQMEHQKERNSFEERIQALEEDL 299 + V++ + L A E EK +ET + Q + ++E I EDL Sbjct: 2405 IKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEI----EDL 2460 Query: 300 REKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQ 359 + K +I EK + K EK++ + +E RE L+++Q Sbjct: 2461 KMKLVKIDLEKMKNAKEF-------------EKEISATKATVEYQKEVIRLLRENLRRSQ 2507 Query: 360 TQEFQG--SEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERER 417 + SE + S K + ++T+ L+ ++ +E+S L+Q+ E+ Sbjct: 2508 QAQDTSVISEHTDPQPSNKPLTCGG--GSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2565 Query: 418 LEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNERE 454 L K E + L NEV+ + +RE Sbjct: 2566 LIKQKNELLSNN-------QHLSNEVKTWKERTLKRE 2595 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 130 bits (328), Expect = 9e-30 Identities = 344/1681 (20%), Positives = 661/1681 (39%), Gaps = 267/1681 (15%) Query: 48 SEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK 107 SEE ++ + + K+ + EL K+ L+ R +E+M+ K + E K Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKK---LQTREREFQEQMKVALEKSQSEYLKISQE-K 529 Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167 + ESL E E ++ KA+ + +E ++Q+ E R ++ ++E L K + Sbjct: 530 EQQESLALEELELQK------KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583 Query: 168 E---KDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLD------ 217 + KD+ A E EK + K + + +E +E++ + H+ D L Sbjct: 584 KNQSKDL-AVHLEAEK----NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY 638 Query: 218 --EKDRLIE----ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAA------ 265 E ++L E E + LK KE + Q EE ++ +V EL L + Sbjct: 639 QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698 Query: 266 PREEKERETEAAQMEHQKERNSFEERIQALEEDLRE------KEREIATEKKNSLKRDKA 319 R + E E + + K + E ++ + ++ KE E++ ++ +D+ Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ- 757 Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEAL 379 I L + LK ++K ++E + +E L A ++ LQ+A + + Y++A Sbjct: 758 INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK-LDVFQSYQSA------- 809 Query: 380 SAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT---- 435 + TK+ E + ++ Q+L DL+ ER L K + E +K K CT Sbjct: 810 -----THEQTKAYEEQ-----LAQLQQKLLDLETERILLTKQVAEVEAQK-KDVCTELDA 858 Query: 436 ----IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTN---- 487 ++DL ++EK +E+ ++ K++ Y+S L + NK+ QEQ + L E N Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE---QEQTKQILVEKENMILQ 915 Query: 488 -------QKDVLLQKFNEKDLEV-IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539 + ++L QK + K+ + I Y ++ E + E + +K Q K + Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME-KVKQKAKEMQETLKKKL 974 Query: 540 FSKEKKQSSDYEE-LIQVLKKEQDIYTHLVKSLQE-----SDSINNLQA----ELNKIFA 589 +E K + E +++ +KE+ +++ Q SD+++ L+ ++ + Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034 Query: 590 LRKQLEQDVLSY--QNLRKTLEE--QISEIRRREEESFSLYSDQTSYLSICLEENNRFQV 645 + ++ DV+S + L + EE +I EI+ +E+E Q L C +E ++ Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094 Query: 646 EHFS-------------QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692 QE+LK+K + + L ++ HL+K DL+ Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN------KSLK 1148 Query: 693 DRLASTEQTELLASKEDEDTIKIGE--------DDEINFLSDQHLQQSNEIMKDLSKGGC 744 + EQ L +ED K+ E D+E L H ++SN+ ++D S Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH-EKSNKSLEDKSLEFK 1207 Query: 745 KNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLL 804 K + I C A + IN+ + N + + + KV LL+ Sbjct: 1208 KLSEELAIQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266 Query: 805 GQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQ-TNSFSKPHDELKLSCEAQLVKAGEV 863 ++E E L T +Q + F Q T+ + +++K Sbjct: 1267 KTCTVSELEAQLRQL------TEEQNTLNISFQQATHQLEEKENQIK------------- 1307 Query: 864 PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALL 923 A ++++ TE + L+ + ++A EK + EN++ V Sbjct: 1308 ----SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT------- 1356 Query: 924 SLPGITNREAKKSRLPI------LIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKE 977 + E K+ ++ I L + L N L + ++ L+ Q E + EL Sbjct: 1357 ----LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL-- 1410 Query: 978 FKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDK 1037 L Q L+ V T K ++A V + + E K K S + + Sbjct: 1411 -------LDQVQDLSFKV----DTLSKEKISALEQVD-DWSNKFSEWKK-KAQSRFTQHQ 1457 Query: 1038 EMDSDQQRSYEIDS-EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMG 1096 + Q E+ S E D+ +L + + ++ KS+ K S + Sbjct: 1458 NTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE 1517 Query: 1097 TD-QSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQD 1155 T+ +S++ +++ QK ++E+ E +N + QK + E + + + Sbjct: 1518 TELKSQTARIMELEDHITQKTIEIESLNEVLKN--YNQQKDIEHKELVQKL---QHFQEL 1572 Query: 1156 GLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV------LENLKQQLEEQ 1209 G K + EE + +QV +K E ++ V L+ L+ +LE + Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632 Query: 1210 ------EYKLQKEQN---LNMQLFSEIHNLQNKFRDLSPPRYDSL---VQSQARELSLQR 1257 E K + EQ + QL S++ + +++ + L +Q + RE+ + Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692 Query: 1258 QQIKDGHG----ICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE 1313 +++K ++ R N + A+ E +A D CV + ++E+++ L + E Sbjct: 1693 EKLKSVESSQSETLIVPRSAKN--VAAYTEQEEA-DSQGCVQKTYEEKISVLQRNLTEKE 1749 Query: 1314 KLFL-------NGKSVGVEMNTQ----------------------NELMERIEEDNLTYQ 1344 KL S EM Q L E +EE N Y Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809 Query: 1345 HLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRT 1404 ++ + E + + ++ F QK E E T ++ ++L +++ Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869 Query: 1405 LRKRLEESIKTNEKLRKQLERQG----SEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQ 1460 R +EE EKL+ + G +E ++ +T + + L S + Q+ Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN---MEAQHN 1926 Query: 1461 ALNAMLIKGSRDKQKENDK-------LRESLSRKTVSLEHLQREYASVKEENERLQKEGS 1513 L L R+KQK + LR LE L++EY +EE + ++E Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986 Query: 1514 EKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573 E +HN L Q +R +L++ ++E++ ++ + + ++ VE + E EE + Sbjct: 1987 EL-KHNSTLKQLMREFNTQLAQKEQELE-----MTIKETINKAQEVEAELLESHQEETNQ 2040 Query: 1574 L 1574 L Sbjct: 2041 L 2041 Score = 105 bits (261), Expect = 5e-22 Identities = 301/1485 (20%), Positives = 591/1485 (39%), Gaps = 299/1485 (20%) Query: 157 EDLLTKRILLLEKDVTAAQ---AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMA 213 ++ L +R+ +E+ +++ + +EL A+ + EK + S+ + +L Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195 Query: 214 LVLDE--KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKE 271 L +D+ K L EE SL+ K+ I L+ +Q++ + + +G + P + E Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQ---TQVSLLKQRLRNGPMNVDVLKPLPQLE 252 Query: 272 RETEAAQMEHQKERN--------SFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323 + E E E + + + ++ L++ ++ +E + K+ + L Sbjct: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLL 312 Query: 324 TMALKSKEKKVEELNSEIEKLS----AAFAKAREALQKA-----QTQEFQGSEDYETALS 374 T ++ +++++E E+EK+ A K L+ A Q ++ +G ET Sbjct: 313 TSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372 Query: 375 GKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDC 434 E L K E +LR IK++T + +L++++E+ E+ A E K Sbjct: 373 MHETLEM--------KEEEIAQLRSRIKQMTTQGEELREQKEKSER---AAFEELEKALS 421 Query: 435 TIRDLRNEVEKLRNEVNER----EKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490 T + KL+ E++E+ EK E SL E ++ +++V+ + +S+ ++ Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV---KQEVVDVMKKSSEEQI 478 Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550 LQK +EK+L R E +T+K +++ ++ Sbjct: 479 AKLQKLHEKEL----------------ARKEQELTKKLQTRE---------------REF 507 Query: 551 EELIQV-LKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLE 609 +E ++V L+K Q Y + + ++ +S+ + EL K A+ + E + Q +T Sbjct: 508 QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK-KAILTESENKLRDLQQEAETYR 566 Query: 610 EQISEIRRREEESFSLYSDQTSYLSICLE-ENNRFQVE-HFSQEELKKKVSDLIQLVKEL 667 +I E+ E+S +Q+ L++ LE E N+ E E+ K ++ L L Sbjct: 567 TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626 Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727 +T+ + K + + E L K +++ + +D EI F Sbjct: 627 WTEKLQVLKQQYQ------------------TEMEKLREKCEQEKETLLKDKEIIF--QA 666 Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787 H+++ NE K L K K L S++S+ A LEE +++L +K Sbjct: 667 HIEEMNE--KTLEKLDVKQTELESLSSELSEV--LKARHKLEEE--LSVLKDQ-TDKMKQ 719 Query: 788 LLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFV--QTNSFSKP 845 LE++ D K + + + + E EVS + +TEK K + + + + + K Sbjct: 720 ELEAKMDEQKNHHQQQVDSI-IKEHEVSIQ----RTEKALKDQINQLELLLKERDKHLKE 774 Query: 846 HDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE---AWEEKPINTA 902 H + EA + ++ + +Q + + D+ + AT E A+EE+ Sbjct: 775 HQAHVENLEADIKRS---------EGELQQASAKLDVFQSYQSATHEQTKAYEEQ----L 821 Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVT 962 + + +L +L + EA+K ++V T Sbjct: 822 AQLQQKLLDLE-----TERILLTKQVAEVEAQK----------------------KDVCT 854 Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPG 1022 +L + +++Q +++ + N ++ QK+ V E + +D Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK-----------------LEDGNK 897 Query: 1023 EQKGIKTTSSVWRDKE-----MDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTS 1077 EQ + T + +KE M Q++ EI L S KE+ +L+ Sbjct: 898 EQ---EQTKQILVEKENMILQMREGQKKEIEI---------LTQKLSAKEDSIHILN-EE 944 Query: 1078 VATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETEL-EGYQNFIFQL-QK 1135 T ++ + KV + E+ LK+K+ D E +L + +N +L QK Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQET---------LKKKLLDQEAKLKKELENTALELSQK 995 Query: 1136 HSQCSEAIITVL-CGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMI 1194 Q + ++ + + G D +S+ + + + + +H+ E+ Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--------------RELN 1041 Query: 1195 DSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254 D V+ +++L +Q +LQ EIH +Q +Q + +E++ Sbjct: 1042 D--VISIWEKKLNQQAEELQ-----------EIHEIQ--------------LQEKEQEVA 1074 Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL-- 1312 +Q+I + ++ MN I +E D QEQL Q + + L Sbjct: 1075 ELKQKIL----LFGCEKEEMNKEITWLKEEGVKQDT---TLNELQEQLKQKSAHVNSLAQ 1127 Query: 1313 EKLFLNGKSVGVEMNTQNELMER-IEEDNLTYQHLLPESPEPSASHALSDYETSEKSF-- 1369 ++ L +E++ L E ++ L +L E + S S +T+++ F Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187 Query: 1370 -FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGS 1428 S +K + E S+ S++L ++ L+ K E L LE + + Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQ-----------LDICCKKTEAL---LEAKTN 1233 Query: 1429 EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGS---------RDKQKENDK 1479 E + S S+ ++ L+ H + + A+LIK R +E + Sbjct: 1234 ELIN------ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287 Query: 1480 LRESLSRKTVSLEHLQREYASVK-------EENERLQKEG-------SEKERHNQQLIQE 1525 L S + T LE + + S+K E E LQKEG SEKE QL +E Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347 Query: 1526 VRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570 + + ++ ++EE+K ++ +S K L L V+L+ L E+ Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392 Score = 83.6 bits (205), Expect = 2e-15 Identities = 153/776 (19%), Positives = 327/776 (42%), Gaps = 133/776 (17%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123 E+ IT+LKKE + ++E ++++ KVE+ SL ++L + Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEK---------------KVEISSLSKQLTDLNVQ 1382 Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183 L + E A A S ++ E+ + + QV+DL K L ++ ++A + + + Sbjct: 1383 LQNSISLSEKEA-AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441 Query: 184 GTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK-- 241 +E +K + R + +K++ + EKD I LK L + CLK Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE 1501 Query: 242 --EEKSQMACPDENVSSGELRGLCAAPREEKERETEAA-----------------QMEHQ 282 ++KS+M + N+ + EL+ A E ++ T+ +EH+ Sbjct: 1502 MEDDKSKMEKKESNLET-ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560 Query: 283 K---ERNSFEE-------RIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEK 332 + + F+E R++ EE + E ++ + K + K ++ + +++KSKE+ Sbjct: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620 Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392 +++ L +E SA AK E +KA+ + + + + KE + K T Sbjct: 1621 ELKALEDRLESESA--AKLAELKRKAEQKIAAIKKQLLSQMEEKE--------EQYKKGT 1670 Query: 393 ENH--RLRRSIKKITQELSDLQQERERLEKDLEE------------AHREKSKGD---CT 435 E+H L +++ +E+ L+++ + +E E A+ E+ + D C Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730 Query: 436 IRDLRNEVEKLRNEVNEREKAM----ENRYKSLLSESNKKLHNQEQVIK-HLTESTNQKD 490 + ++ L+ + E+EK + + + +++ S + QE++IK E+ +D Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790 Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550 + +++LE + L+ A+ +E EG K + Q + +F +K + Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVE--KEG---GKNNIQAKQNLENVFDDVQKTLQEK 1845 Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLE- 609 E Q+L+++ ++E DS Q E++++ ++E+ Y+ L+ + Sbjct: 1846 ELTCQILEQK----------IKELDSCLVRQKEVHRV-----EMEELTSKYEKLQALQQM 1890 Query: 610 ----EQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKV-SDLIQLV 664 + + EE + Q LS ++N + + E K+K+ ++++L Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ 1950 Query: 665 KELYT----------------DNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE 708 K+L D + +K + + + N +L T+ LA KE Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQ-LAQKE 2009 Query: 709 DE------DTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISD 758 E +TI ++ E L + H +++N+++K +++ K+ L+ T + + Sbjct: 2010 QELEMTIKETINKAQEVEAELL-ESHQEETNQLLKKIAE---KDDDLKRTAKRYEE 2061 Score = 70.9 bits (172), Expect = 1e-11 Identities = 286/1524 (18%), Positives = 584/1524 (38%), Gaps = 296/1524 (19%) Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE--------- 452 KK+ Q++S+ QQ+ L++ L A + S T +R+ +++E Sbjct: 3 KKLKQKISEEQQQ---LQQALAPA--QASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGD 57 Query: 453 ----------REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502 R ++E+ ++S + ES + ++E +++ T+ ++ L N DL+ Sbjct: 58 TQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVR-----TSSRESL----NRLDLD 108 Query: 503 VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS---DYEELI---QV 556 D++ +E L+ S + + + E+ SS Y EL+ Q+ Sbjct: 109 --SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQM 166 Query: 557 LKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR 616 L++E+ ++ Q+ L +I LR++L+ D Q +K L+E+ Sbjct: 167 LQREKKKLQGILSQSQDKS--------LRRIAELREELQMD----QQAKKHLQEEFDASL 214 Query: 617 RREEESFSLYSDQTSYLSICLEENNRF------------QVEHFSQEELKKKVSDLI--- 661 +++ S+ Q S L L Q E F++EE + + + Sbjct: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274 Query: 662 -QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 VK L T Q +K+ + L ++T + S +++ T+ E + Sbjct: 275 GTSVKTLETLQQRVKRQ--------------ENLLKRCKET--IQSHKEQCTLLTSEKEA 318 Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780 + D+ LQ+ +I KDL ++ I+ A NL+ L Sbjct: 319 LQEQLDERLQELEKI-KDL--------HMAEKTKLITQLRDAK-----------NLIEQL 358 Query: 781 FNEKATLLLESRPDLLKVV--RELLLGQLF--LTEQEVSGEHLDGKTEKTP--------- 827 +K ++ E++ + + + +E + QL + + GE L + EK+ Sbjct: 359 EQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEK 418 Query: 828 -------------KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQ 874 K K E+ ++T K +E ++S + +L + + +K +S + Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKT--IEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476 Query: 875 TVAT-----EGDLLRFKHEAT-----REAWEEKPINTALSAEHRPENLHGVPGWQAALLS 924 +A E +L R + E T RE ++ + AL Q L+ Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536 Query: 925 LPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQ 984 L E + + IL + L ++ Q+ +++ILEL+ L++ NK Sbjct: 537 L-----EELELQKKAILTESENKLRDL------QQEAETYRTRILELESSLEKSLQENKN 585 Query: 985 LHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIK-TTSSVWRDKEMDSDQ 1043 + L + + + + T++ + E + +K ++W +K Q Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVM---------VEKHKTELESLKHQQDALWTEKLQVLKQ 636 Query: 1044 QRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESI 1103 Q E++ C++ E +L + + + + Q+E Sbjct: 637 QYQTEMEK---------LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687 Query: 1104 NTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNG 1163 + S+E + + H LE EL ++ Q K Q EA + + KN Sbjct: 688 SLSSELSEVLKARHKLEEELSVLKD---QTDKMKQELEA-------------KMDEQKNH 731 Query: 1164 SDGEEMTFSSLHQVRYVKHVKILG------PLAPEMIDSRV------LENLKQQLEEQEY 1211 + + H+V + K L L + D + +ENL+ ++ E Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791 Query: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271 +LQ + + + +F + Q+ + + + L Q Q + L L+ ++I + + Sbjct: 792 ELQ-QASAKLDVF---QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEA 847 Query: 1272 QHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNE 1331 Q + + +Q D+ Q+ Q +E+ +K++ L +S + N + E Sbjct: 848 QKKDVCTELDAHKIQVQDL-------MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900 Query: 1332 LMERI--EEDNLTYQ---------HLLPE--SPEPSASHALSDYETSEKSFFSRDQKQDN 1378 ++I E++N+ Q +L + S + + H L+ E E F ++++K + Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN--EEYETKFKNQEKKMEK 958 Query: 1379 ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQ-GSTSI 1437 +K M + + LL + + L+K LE + + KQ + E Q S I Sbjct: 959 VKQKAKEMQETLKKKLLDQEAK----LKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014 Query: 1438 FASGSELHSSLTSEIHFLRK-QNQALNAMLIKGSRDKQKENDKLRE----SLSRKTVSLE 1492 + S L ++ +I L + + LN ++ + ++ ++L+E L K + Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVA 1074 Query: 1493 HLQRE---YASVKEENER----LQKEGSEKERHNQQLIQEVRCSGQEL-SRVQEEVKLRQ 1544 L+++ + KEE + L++EG +++ +L ++++ + S Q+E KL+ Sbjct: 1075 ELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA 1134 Query: 1545 QLLSQNDKLLQSLRVELKAYEKL-------DEEHRRLRDGDKYPMESDNSFDLFDSSQAV 1597 L L +SL+ E+L +E+ R++ + +D F SS Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194 Query: 1598 TPKSVSE----------------------TPPLSGNDTDSLSCDSGSSATSTPCVSRLVT 1635 + KS+ + T L T+ L + SS+ + +SR+ Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI--NISSSKTNAILSRISH 1252 Query: 1636 GHHLWASKNGRHVLG--LIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPH 1693 H ++ + + EA L+Q+++ Q L +I Q+A + +L K Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL---NISFQQA----THQLEEKENQ 1305 Query: 1694 PAPLSKFVSSVSTAKLTLE-----------EAYRRLKLLWRVSLPEDGQCPLHCEQIGEM 1742 + + S+ T K L+ E + L + L E++ E Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365 Query: 1743 KAEVTKLHKKLFEQEKKLQNTMKL 1766 K E++ L K+L + +LQN++ L Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISL 1389 Score = 58.9 bits (141), Expect = 4e-08 Identities = 104/511 (20%), Positives = 212/511 (41%), Gaps = 91/511 (17%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV---EVESLKRELQ-- 118 E +I +KK+ + +EE+ +Q G H+ + N +L+ EV L+ +L+ Sbjct: 1645 EQKIAAIKKQLLSQ------MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV 1698 Query: 119 ---EREQLLI-KASKAVESLAEAGGSEIQR-VKEDARKKVQQVEDLLTKRILLL-----E 168 + E L++ +++K V + E ++ Q V++ +K+ ++ LT++ LL E Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758 Query: 169 KDVTAAQ------------AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMAL-- 214 K+ T + +LE A A ++++ L+ +L E K + +A + Sbjct: 1759 KEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK 1818 Query: 215 ---------------VLDEKDRLIEELKLSLKSKEALIQ----CLKEEKSQMACPDENVS 255 V D+ + ++E +L+ + E I+ CL +K E ++ Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878 Query: 256 SG--ELRGLCAA-----PREEKERETEAAQMEH----------QKERNSFEERIQALEED 298 S +L+ L P E E TE H + + N E ++ E + Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938 Query: 299 LREKEREIATEKKNSLKRDKAIQGLTMALKSK--EKKVEELNSEIEKLSAAF-AKAREAL 355 ++ +EI +K+ K Q LK + +++ E++ E E L + ++ + Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLM 1998 Query: 356 QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415 ++ TQ Q ++ E + KE ++ A + + + +KKI ++ DL++ Sbjct: 1999 REFNTQLAQKEQELEMTI--KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTA 2056 Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ 475 +R E+ L+ E + +RDL+ ++E+L+ + ++ + EN N Sbjct: 2057 KRYEEILDAREEEMT---AKVRDLQTQLEELQKKYQQKLEQEENP------------GND 2101 Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLEVIQQ 506 I L QK L+ K+ E +Q Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132 Score = 49.7 bits (117), Expect = 3e-05 Identities = 118/611 (19%), Positives = 245/611 (40%), Gaps = 86/611 (14%) Query: 1200 ENLKQQLEEQEYKLQKEQNLNM----QLFSEIHNLQNKFRDLSPPR----------YDSL 1245 E L++QL+E+ +L+K ++L+M +L +++ + +N L + Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 376 Query: 1246 VQSQARELSLQRQQIK----DGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG---F 1298 ++ + E++ R +IK G + Q + AFEEL +A E Sbjct: 377 LEMKEEEIAQLRSRIKQMTTQGE---ELREQKEKSERAAFEELEKALSTAQKTEEARRKL 433 Query: 1299 QEQLNQCAELLEKL---EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355 + ++++ + +EK E++ L + V+ + + + EE Q L + Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493 Query: 1356 SHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKT 1415 +T E+ F ++ EK+ SQ+ + + L + + + Sbjct: 494 QELTKKLQTREREF---QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE 550 Query: 1416 NEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQK 1475 +E + L+++ + T I EL SSL + + Q++ L L +K K Sbjct: 551 SENKLRDLQQEAETY---RTRIL----ELESSLEKSLQENKNQSKDLAVHL---EAEKNK 600 Query: 1476 ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKE--GSEKERHNQQLIQEVRCSGQEL 1533 N ++ + + LE L+ + ++ E ++ K+ +E E+ ++ QE +E Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE-----KET 655 Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVE--------------LKAYEKLDEEHRRLRD-GD 1578 +E+ + + N+K L+ L V+ LKA KL+EE L+D D Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715 Query: 1579 KYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHH 1638 K E + D + S+ + +S T+ D + + L+ Sbjct: 716 KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ------LELLLKERD 769 Query: 1639 LWASKNGRHVLGLIEDYEALLKQISQG--QRLLAEMDIQTQEAPSSTSQELGTKGPHPAP 1696 ++ HV E+ EA +K+ S+G Q+ A++D+ Q S+T ++ A Sbjct: 770 KHLKEHQAHV----ENLEADIKR-SEGELQQASAKLDV-FQSYQSATHEQTKAYEEQLAQ 823 Query: 1697 LSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQ 1756 L + + + T ++ L + + + Q C ++ K +V L ++L +Q Sbjct: 824 LQQKLLDLETERILLTKQVAEV----------EAQKKDVCTELDAHKIQVQDLMQQLEKQ 873 Query: 1757 EKKLQNTMKLL 1767 +++ +K L Sbjct: 874 NSEMEQKVKSL 884 >gi|50658075 phosphodiesterase 4D interacting protein isoform 3 [Homo sapiens] Length = 310 Score = 127 bits (320), Expect = 8e-29 Identities = 70/148 (47%), Positives = 97/148 (65%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 ++DFE + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ+ Sbjct: 142 LRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQD 201 Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179 ++Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E Sbjct: 202 KKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 261 Query: 180 KAFAGTETEKALRLRLESKLSEMKKMHE 207 + A E EK L L KL + K E Sbjct: 262 RMAALVEAEKECNLELSEKLKGVTKNWE 289 Score = 32.0 bits (71), Expect = 5.6 Identities = 40/161 (24%), Positives = 70/161 (43%), Gaps = 22/161 (13%) Query: 172 TAAQAELEKAFAGTETEK-ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSL 230 T A + EK + E +L+LR+ M++ +E D R IE LK+ + Sbjct: 139 TQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRE-----DIYKRNIE-LKVEV 192 Query: 231 KSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEE 290 +S + +Q K+ + EN++S E R+ E Q E + E Sbjct: 193 ESLKRELQDKKQHLDKTWADVENLNSQN--------EAELRRQFEERQQETEHVYELLEN 244 Query: 291 RIQALEEDLREKEREIA-------TEKKNSLKRDKAIQGLT 324 +IQ L+E+ R + E A EK+ +L+ + ++G+T Sbjct: 245 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 285 Score = 31.2 bits (69), Expect = 9.6 Identities = 29/112 (25%), Positives = 61/112 (54%), Gaps = 15/112 (13%) Query: 399 RSIKKITQELSDLQQERERLEKD---LEEAHREK---SKGDCTIR--DLRNEVEKLRNEV 450 ++++ + L+DL++E L+ LEE ++K S+ D R +L+ EVE L+ E+ Sbjct: 140 QALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL 199 Query: 451 NEREKAMENRY---KSLLSESNKKLHNQ----EQVIKHLTESTNQKDVLLQK 495 ++++ ++ + ++L S++ +L Q +Q +H+ E K LLQ+ Sbjct: 200 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 251 >gi|50658077 phosphodiesterase 4D interacting protein isoform 4 [Homo sapiens] Length = 173 Score = 120 bits (300), Expect = 2e-26 Identities = 67/147 (45%), Positives = 93/147 (63%) Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 + + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++ Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65 Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 +Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E + Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125 Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE 207 A E EK L L KL + K E Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWE 152 Score = 32.7 bits (73), Expect = 3.3 Identities = 30/109 (27%), Positives = 60/109 (55%), Gaps = 15/109 (13%) Query: 402 KKITQELSDLQQERERLEKD---LEEAHREK---SKGDCTIR--DLRNEVEKLRNEVNER 453 + ++Q L+DL++E L+ LEE ++K S+ D R +L+ EVE L+ E+ ++ Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65 Query: 454 EKAMENRY---KSLLSESNKKLHNQ----EQVIKHLTESTNQKDVLLQK 495 ++ ++ + ++L S++ +L Q +Q +H+ E K LLQ+ Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114 Score = 31.6 bits (70), Expect = 7.3 Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 15/107 (14%) Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284 ELK+ ++S + +Q K+ + EN++S E R+ E Q E + Sbjct: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQN--------EAELRRQFEERQQETEHV 101 Query: 285 RNSFEERIQALEEDLREKEREIA-------TEKKNSLKRDKAIQGLT 324 E +IQ L+E+ R + E A EK+ +L+ + ++G+T Sbjct: 102 YELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 148 >gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens] Length = 1116 Score = 116 bits (291), Expect = 2e-25 Identities = 167/777 (21%), Positives = 313/777 (40%), Gaps = 129/777 (16%) Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIE-LKVEVESLKRE 116 R ++D E +I LK N L EE M+Q +Y+++ + +K +VE LK E Sbjct: 396 RGLRDLEEEIQMLKS---NGALSTEEREEEMKQM------EVYRSHSKFMKNKVEQLKEE 446 Query: 117 LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-------------R 163 L +E + K L +EI +VK++ +K ++ L TK Sbjct: 447 LSSKEAQWEELKKKAAGLQ----AEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 502 Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESK-------------LSEMKKMHEGDL 210 I +L++ +TA E A TE + ALRLRLE K ++E K G++ Sbjct: 503 IEVLKESLTAK--EQRAAILQTEVD-ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559 Query: 211 A-MALVLDEKDRL-------IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSG----- 257 + +LD K+R IE L+ L+ KE + LKE + N + Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619 Query: 258 ----ELRGLCAAPREEKERETEAAQME---HQKERNSFEERIQALEEDLREKEREIATEK 310 E +E+++R+ Q E ++K+ +E++ L+ DL EKE + K Sbjct: 620 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679 Query: 311 KNS-------LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEF 363 +++ LK+D ++ L +AL+ K+++ ++ S+++K Sbjct: 680 EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA------------------- 720 Query: 364 QGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLE 423 +E AL + + + R Q+L R I + E S Q E +RL + L+ Sbjct: 721 -----HEAALEARASPEMSDRIQHL---------EREITRYKDESSKAQAEVDRLLEILK 766 Query: 424 EAHREKSKGDCTIRDLRNEVEKLRNEV---NEREKAMENRYKSLLSESNKKLHNQEQVIK 480 E EK+ D I +L +V+ +V +E+ + + +L E+ ++ N + Sbjct: 767 EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQ 826 Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQ----QNCYLMAAEDLELRSEGLITEKCSSQQPPGS 536 L +S +KD +++ E E +Q + L E +E + E + + Sbjct: 827 QLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV-K 885 Query: 537 KTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQ 596 + + S + K SS + L + KE + + + + + ++ E K Sbjct: 886 QELESMKAKLSSTQQSLAE---KETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942 Query: 597 DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN---NRFQVEHFSQEEL 653 +L + +K +E+++ ++R ++ QT + +N + F+ H +Q Sbjct: 943 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002 Query: 654 KKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTI 713 K +IQ + EL + LK I L+ L +L + Sbjct: 1003 KPSPDQIIQPLLELDQNRSKLKLYIGHLTT-----------LCHDRDPLILRGLTPPASY 1051 Query: 714 KIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEE 770 + +DD+ + ++ ++ +L KG N L+ + I H P LE+ Sbjct: 1052 NL-DDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQ 1107 Score = 67.8 bits (164), Expect = 9e-11 Identities = 189/923 (20%), Positives = 365/923 (39%), Gaps = 152/923 (16%) Query: 40 GNGLLPNVSEETVSP-----TRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHG 94 G LP VS + P R + D + Q+ E+ +EN L+ + E ++ + Sbjct: 126 GEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNS 185 Query: 95 PTEHIYKT--NIELKVEVESLKREL------QEREQLLIKASKAVESLAEAGGSEIQRVK 146 KT + ELK E K E +E+ +++ + ++ ++ +A E+ R++ Sbjct: 186 -----IKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-RIQ 239 Query: 147 EDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH 206 D + QQ T + E + ++ A E + L L EM+ Sbjct: 240 RDLNQLFQQDSSSRTGEPCVAE----LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI 295 Query: 207 EGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAA 265 E L+ +D I++L L+SK + +E+ + + + L L Sbjct: 296 E---TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL-- 350 Query: 266 PREEKERETEAAQME-HQKERNS---------------FEERIQALEEDLREKEREI--- 306 E+KE+E + E H++ N+ + +I ++E LR+ E EI Sbjct: 351 --EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408 Query: 307 -------ATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQ 359 E++ +K+ + + + +K+K ++++ E+LS+ A+ E +KA Sbjct: 409 KSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK------EELSSKEAQWEELKKKA- 461 Query: 360 TQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLE 419 +G +A ++ + K TE L+ ++ +T + SD +Q E L+ Sbjct: 462 --------------AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK 507 Query: 420 KDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQV- 478 + L + + L+ EV+ LR + E+E + + K + + +K ++ Sbjct: 508 ESLTAKEQRAA-------ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560 Query: 479 -IKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSK 537 +K + + +K +LQK E E ++ M++ ++S T + + Sbjct: 561 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620 Query: 538 TIFSKEK-----KQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRK 592 + KE+ K+ D +E + ++E D Y +K L+E S+ LQ +L++ A Sbjct: 621 ALAEKERTIERLKEQRDRDE--REKQEEIDNYKKDLKDLKEKVSL--LQGDLSEKEASLL 676 Query: 593 QLEQDV--LSYQNLRKTLEEQISEI--RRREEESFSLYSDQTSYLSICLE----ENNRFQ 644 L++ L+ L+K + EI +++EE + S LE + Sbjct: 677 DLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736 Query: 645 VEHFSQE---------ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL 695 ++H +E + + +V L++++KE+ + K I +L N L Sbjct: 737 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL 796 Query: 696 ASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESK 755 EQ E S + + + ED+ + S Q LQ S LR + + Sbjct: 797 KHKEQVEKKKSAQMLEEARRREDNLND--SSQQLQDS----------------LRKKDDR 838 Query: 756 ISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLE---SRPDLLKVVRELLLGQLFLTEQ 812 I + + A L E I E+ +L + +R + K V ELL+ + +Q Sbjct: 839 IEELEEA-----LRESVQITA------EREMVLAQEESARTNAEKQVEELLMA-MEKVKQ 886 Query: 813 EVSGEHLDGKTEKTPKQKGEL-VHFVQTNSFSKPHDE--LKLSCEAQLVKAGEV-PKVGL 868 E+ E + K T + E H + + H E L++ EA L E + L Sbjct: 887 EL--ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944 Query: 869 KDASVQTVATEGDLLRFKHEATR 891 + S T+ ++ K E R Sbjct: 945 LELSSSKKKTQEEVAALKREKDR 967 Score = 47.4 bits (111), Expect = 1e-04 Identities = 85/369 (23%), Positives = 148/369 (40%), Gaps = 44/369 (11%) Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 LE+L +Q E++ L++E + + + + + K DS + S R L + Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPD--SAKTKALQTVIEMKDSKISSMERGLRDLEE 403 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 +I+ +S + +K E S E +E+L+ E+L+K Sbjct: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK---- 459 Query: 1319 GKSVGV--EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376 K+ G+ E+ + + R + + L Q L ET F D KQ Sbjct: 460 -KAAGLQAEIGQVKQELSRKDTELLALQTKL---------------ETLTNQF--SDSKQ 501 Query: 1377 DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS 1436 E K S+ +L E+ LR RLEE K KQ++ E + Sbjct: 502 HIEVLKESLTAKEQRAAILQT---EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE 558 Query: 1437 IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRE---SLSRKT----V 1489 I ++ +++ L+K+ + L L RDK+K+ L+E SL T Sbjct: 559 IH-DLKDMLDVKERKVNVLQKKIENLQEQL----RDKEKQMSSLKERVKSLQADTTNTDT 613 Query: 1490 SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQ 1549 +L L+ A + ERL+++ ER Q+ I + ++L ++E+V L Q LS+ Sbjct: 614 ALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK---KDLKDLKEKVSLLQGDLSE 670 Query: 1550 NDKLLQSLR 1558 + L L+ Sbjct: 671 KEASLLDLK 679 Score = 41.2 bits (95), Expect = 0.009 Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 45/397 (11%) Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 +ENL++QL ++E ++ + L ++ N L ++L + + L+ Q Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE----EALAEKERTIERLKEQ 635 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 + +D R+ + ++L + + E+ +L E L + Sbjct: 636 RDRD-------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 688 Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD-QKQD 1377 G + T +E+ +E+ L + L ++ E + S + R+ + Sbjct: 689 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 748 Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRK-------RLEESIK------TNEKLRKQLE 1424 +E+ K V D L+E ++E+ + LE +K N K ++Q+E Sbjct: 749 DESSKAQAEV-----DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 803 Query: 1425 RQGS-----EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN-AMLIKGSRDKQKEND 1478 ++ S E + ++ S +L SL + + + +AL ++ I R+ + Sbjct: 804 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 863 Query: 1479 KLRESLSRKTV-----SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533 + + + K V ++E +++E S+K + Q+ +EKE H L E R +E+ Sbjct: 864 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923 Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570 +++E L +S+ D + L EL + +K +E Sbjct: 924 LEMKQEALL--AAISEKDANIALL--ELSSSKKKTQE 956 Score = 38.9 bits (89), Expect = 0.046 Identities = 51/219 (23%), Positives = 94/219 (42%), Gaps = 35/219 (15%) Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445 M ++ L I L+ +L+E ++ N+ LRK +E + S+ SI Sbjct: 135 MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI----KTFW 190 Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505 S + LRK + + + R Q+EN ++ ++++ LQ E ++ N Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-------MTIQALQDELRIQRDLN 243 Query: 1506 ERLQKEGSEK----------ERHNQQLIQEVRCSGQEL---SRVQEEVKLR----QQLLS 1548 + Q++ S + E + Q+L E +EL + EE++LR +Q L+ Sbjct: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303 Query: 1549 QNDK-------LLQSLRVELKAYEKLDEEHRRLRDGDKY 1580 D+ +LQS + KA E+ E RRL + + + Sbjct: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH 342 Score = 38.9 bits (89), Expect = 0.046 Identities = 57/263 (21%), Positives = 112/263 (42%), Gaps = 26/263 (9%) Query: 1326 MNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---ETEK 1382 M+ Q +L E + E++L + + E E S +++ S K+F+S + K++ + E Sbjct: 152 MDLQTQLKEVLRENDLLRKDV--EVKESKLSSSMN----SIKTFWSPELKKERALRKDEA 205 Query: 1383 TSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGS 1442 + + + ++ E Q ++ + L++ ++ L QL +Q S G + Sbjct: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-QLFQQDSSSRTGEPCVAELTE 264 Query: 1443 EL-------HSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495 E H E+ LRK + + + + QK+ R+ +K + + + Sbjct: 265 ENFQRLHAEHERQAKELFLLRKTLEEMELRI-----ETQKQTLNARDESIKKLLEMLQSK 319 Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLL--SQNDKL 1553 A EE+ + +E E H L + +E S ++EE+ R + S K Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379 Query: 1554 LQSLRVELKAYEKLDEEHRRLRD 1576 LQ++ +E+K K+ R LRD Sbjct: 380 LQTV-IEMKD-SKISSMERGLRD 400 Score = 38.5 bits (88), Expect = 0.060 Identities = 77/448 (17%), Positives = 183/448 (40%), Gaps = 33/448 (7%) Query: 1096 GTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKH-SQCSEAIITVLCGTEGAQ 1154 GT E + + + ++K++ L+ ++E Q + +K S E + ++ T Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612 Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDS--RVLENLKQQLEEQEYK 1212 L+ + +E T L + R + E ID+ + L++LK+++ + Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDERE-----KQEEIDNYKKDLKDLKEKVSLLQGD 667 Query: 1213 LQKEQNLNMQLFSEIHNLQNKF--RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270 L +++ + L +L + +D + ++ + E Q+K H + + Sbjct: 668 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 727 Query: 1271 RQ--HMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGV--- 1324 R M+ I+ E E+ + D + Q ++++ E+L+++E N K + Sbjct: 728 RASPEMSDRIQHLEREITRYKDE----SSKAQAEVDRLLEILKEVENE-KNDKDKKIAEL 782 Query: 1325 --EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---- 1378 ++ QN+ + ++ + + E + + ++S++ S +K D Sbjct: 783 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842 Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437 E + SV + + + +L + K++EE + EK++++LE ++ S+ Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902 Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497 + L + L + + L+ +K L S S+K Q E Sbjct: 903 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT-----QEE 957 Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQE 1525 A++K E +RL ++ ++ ++ +L+ + Sbjct: 958 VAALKREKDRLVQQLKQQTQNRMKLMAD 985 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 116 bits (290), Expect = 2e-25 Identities = 195/896 (21%), Positives = 365/896 (40%), Gaps = 180/896 (20%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E+ + TRAR+ K + EL+KEN LK +++ +E + E + + N+ L++ Sbjct: 364 EDQLEGTRARSDK-----LHELEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEM 417 Query: 109 -EVESLKRELQ---EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164 + +S+ L E EQ+ + S+ E+ ++ G E+ + K++ LTK + Sbjct: 418 AQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476 Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLE----SKLSEMKKMHEGDLAMALVLDEKD 220 L V + + K + + L ++E + E + + ++ EK Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536 Query: 221 RLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE----- 275 +L + ++ ++ E I+ L++E + ++ VSS R +A K+ E E Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARVKDIEKENKILH 593 Query: 276 --------------------AAQMEHQKERNSFEERIQALEEDLR--EKEREI------- 306 ++EH KE+ ER + LE +L EKE E+ Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEELENELHHLEKENELLQKKITN 650 Query: 307 ---------ATEKKNS-LKRDK--------AIQGLTMALKSKEKKVEELNSE-------I 341 A E++NS L+R+ + + LT L+S EK+ +L+ E + Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710 Query: 342 EKLSAAFAKAREA------LQKAQTQEFQGSEDYETALSGKEALSAA-----LRSQNLTK 390 E L A K + L+ + Q +G E + + E L + + +Q L K Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770 Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450 + EN + I+++ EL DL+ E + L+K+LEE + + L E + L E Sbjct: 771 TLENSN--KKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQET 824 Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE---KDLEVIQQN 507 ++ EK K L + NK+L Q ++ E N K L+K N+ K++ + +++ Sbjct: 825 SQLEKD-----KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879 Query: 508 CYLMAAEDLELRS----------------EGLITEKCSSQQPPGSKTIFSKE-KKQSSDY 550 C + + E + E L++EK +QQ + E +K + Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939 Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---KT 607 E L+ + D L++S ES +L+ + KI AL +LE+ Q LR KT Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999 Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQL---- 663 +++ +++R++E + S I E+N + + EL K LI++ Sbjct: 1000 VKKNYEALKQRQDEERMVQSSP----PISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055 Query: 664 -------------VKELYTDNQHLKKTIFDL--SCMGFQGNG-----------FPDRLAS 697 +K+L T N +L+ I L + Q + + Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115 Query: 698 TEQTELL----------ASKEDEDTIKIGEDDEINFLSDQ-----------HLQQSNEIM 736 ++ T L+ +S E+E+ I E +++ L D H +Q++E Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175 Query: 737 KDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792 +SK G ++ E + D + + ++G +L L E+ +LLE++ Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1231 Score = 110 bits (274), Expect = 2e-23 Identities = 320/1466 (21%), Positives = 569/1466 (38%), Gaps = 268/1466 (18%) Query: 40 GNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHI 99 G LP+ S SP + MK E++ L E + K +I R++QE TE + Sbjct: 220 GLHFLPHASSSAQSPCGSPGMKRTESR-QHLSVELADAKAKI----RRLRQELEEKTEQL 274 Query: 100 YKTNIELKVEVESLKRELQEREQLLIKASKA------VESLAEAG------GSEIQRVKE 147 EL+ LKR QE LL A A +++L E SE+ R KE Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE 334 Query: 148 ---DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK- 203 D +VE+L +LLE + LE GT LE + ++K Sbjct: 335 RLHDIEFYKARVEELKEDNQVLLE-----TKTMLEDQLEGTRARSDKLHELEKENLQLKA 389 Query: 204 KMHEGDLAMALVLDEKDRLIEE-LKLSLKSKEALIQCLK--EEKSQMACPDENVSSGELR 260 K+H+ ++ + + + L+EE + L + K+++ + L E Q++ E +S + Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-LSEAPQK 448 Query: 261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNS--LKRDK 318 L E +ME+Q + EE ++ + + EK+N K+ + Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508 Query: 319 AIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ-------KAQTQEFQGSEDYET 371 ++ + K + + L+ ++ K A K E L+ K QE + + Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568 Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSK 431 +L + +SA R +++ K EN L SIK+ + +LS ++ E+ +++K+LE K K Sbjct: 569 SLRQRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELE---HYKEK 623 Query: 432 GDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--LSESNKKLHNQEQVIKHLTESTNQK 489 G+ E+L NE++ EK E K + L + +K+ EQ L + Sbjct: 624 GE--------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675 Query: 490 DVLLQKFNEK--DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547 L F LE +++ + E+LELR + + KC+S + ++ + ++ Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELR-RNVESLKCASMK-------MAQLQLEN 727 Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT 607 + E + LKK ++ L+A K L + + Q L+KT Sbjct: 728 KELESEKEQLKKGLEL----------------LKASFKKTERLEVSYQGLDIENQRLQKT 771 Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667 LE +I++ E E L + + L LEE ++ E+L+K+ L Q +L Sbjct: 772 LENSNKKIQQLESELQDLEMENQT-LQKNLEE---LKISSKRLEQLEKENKSLEQETSQL 827 Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727 D + L+K + +Q E+ + +E+ +KIG Sbjct: 828 EKDKKQLEK----------------ENKRLRQQAEIKDTTLEENNVKIG----------- 860 Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787 +L++ N K LSK G + C+ L L E L Sbjct: 861 NLEKEN---KTLSKE-----------------IGIYKESCVR-------LKELEKENKEL 893 Query: 788 LLESRPDL--LKVVRELLLGQLFLTEQEVSG-EHLDGKTEKTPKQKGELVHFVQTNSFSK 844 + + D+ L +RE L+ + T+Q + E L + EK K L+H Q+ S+ Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953 Query: 845 PHDELKLSCEAQLVKAGEV--PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTA 902 + L+ E+ L K+ E+ K+ +A ++ LR + + ++ +E A Sbjct: 954 -YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE------A 1006 Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSR-----LPILIKPSRSLGNMYRLPAT 957 L E + + S P I+ + K R L+K L + R AT Sbjct: 1007 LKQRQDEERM---------VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057 Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQPPVGA 1015 LQ++ L+ +LK+ +T N L +++ + + TL NA+ V Sbjct: 1058 ------LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111 Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE--ICPPDDLASLPSCKENPEDVL 1073 + +S ++S+ QQ S E ++E I +DL SL + L Sbjct: 1112 STLNS--------QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163 Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE--------TEYLKQK--IHDLETEL 1123 + S+ + +S GT +S N E + LKQK + DLE L Sbjct: 1164 E----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1219 Query: 1124 EGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSL---HQVRYV 1180 + Q + K+ + A LCG +D T+S L +V Sbjct: 1220 KVEQEKMLLENKNHETVAAEYKKLCGE-------------NDRLNHTYSQLLKETEVLQT 1266 Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL---QKEQNLNMQLFSEIH-NLQNKFRD 1236 H + L ++ LE +L+EQ +L + N +L S++ NL+ + R Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326 Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE 1296 L Q + L LQ + + E+ +++ D+ + Sbjct: 1327 L---------LDQIQTLMLQNRTL--------------------LEQNMESKDLFHVEQR 1357 Query: 1297 GFQEQLNQCAELLEKLEKLFLN-------------GKSVGVEMNTQNELMERIEEDNLTY 1343 + ++LN+ EKLE+ ++ G + ++M +L++ ++ N Sbjct: 1358 QYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM---RKLIKSKKDINRER 1414 Query: 1344 QHLLPESPEPSASH----ALSDYETSEKSFFSRDQKQDNET--EKTSVMVNSFSQDLLME 1397 Q L +P S S L ++ + S + +D +T K S +N Q +++ Sbjct: 1415 QKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLA 1474 Query: 1398 HIQEIRTLRKRLEESIKTNEKLRKQL 1423 T + + I T K RK+L Sbjct: 1475 GQWTGSTENLEVPDDISTG-KRRKEL 1499 Score = 68.6 bits (166), Expect = 5e-11 Identities = 123/582 (21%), Positives = 239/582 (41%), Gaps = 79/582 (13%) Query: 1030 TSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS 1089 ++ ++RD E+D+ ++++ +D + + KE D+ + L +Q Sbjct: 304 SARMYRD-ELDALREKAVRVDKLE------SEVSRYKERLHDIEFYKARVEELKEDNQVL 356 Query: 1090 AKVSVMGTDQSESINTSN--------ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141 + M DQ E + E LK K+HD+E E + + I +L + + E Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416 Query: 1142 AI------ITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID 1195 ++ G E Q +S+ S+ + + H+V + ++L Sbjct: 417 MAQKQSMDESLHLGWELEQ--ISRTSELSEAPQKSLG--HEVNELTSSRLLKLEMENQSL 472 Query: 1196 SRVLENLKQQLEEQE---YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARE 1252 ++ +E L+ ++ E K+ K + N +L ++ L+N E Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN-------------------E 513 Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312 + ++Q +++ + + + K E L + S+ + E E LNQ L + Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573 Query: 1313 EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSR 1372 ++ + +E + L E I+E + + E + L Y+ EK R Sbjct: 574 SQISAEARVKDIEKENK-ILHESIKETSSKLSKI--EFEKRQIKKELEHYK--EKG--ER 626 Query: 1373 DQKQDNE---TEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSE 1429 ++ +NE EK + ++ +L + ++I L + E + N KL+K L+ Sbjct: 627 AEELENELHHLEKENELLQKKITNLKIT-CEKIEALEQENSELERENRKLKKTLDS---- 681 Query: 1430 FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN------AMLIKGSRDKQKENDKLRES 1483 + T S + +S L E LR+ ++L A L +++ + E ++L++ Sbjct: 682 -FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740 Query: 1484 LSRKTVSL---EHLQREYASVKEENERLQKEGSEKERHNQQL---IQEVRCSGQELSRVQ 1537 L S E L+ Y + EN+RLQK + QQL +Q++ Q L + Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800 Query: 1538 EEVKLRQQLLSQNDKLLQSLRVELKAYEK----LDEEHRRLR 1575 EE+K+ + L Q +K +SL E EK L++E++RLR Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842 Score = 66.2 bits (160), Expect = 3e-10 Identities = 260/1409 (18%), Positives = 533/1409 (37%), Gaps = 241/1409 (17%) Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201 ++++K ++ +QQ+ + +L++ K+ + Q GTE K L L L Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQ--------GTEEVKKLLLLL------ 128 Query: 202 MKKMHEGDLAMALVLDEKDRLIEELK-LSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260 L A+ +K+ IE ++ L +K A+ ++E ENV + Sbjct: 129 --------LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQ----ENVFDLQWM 176 Query: 261 GLCAAPREEKERETEAAQMEHQK---ERNSFEERIQALEEDLREKEREIATEKKNS---- 313 + +E+ E + + ++ ER+ E I L E+ R+ + ++ Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEE-RDGLHFLPHASSSAQSPC 235 Query: 314 ----LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369 +KR ++ Q L++ L + K+ L E+E+ + ++ L++ + + + ++ Sbjct: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295 Query: 370 ETALSGKEALSAALRSQNL----TKSTENHRLRRSIKKITQELSDLQQERERLEK----- 420 LS +A SA + L K+ +L + + + L D++ + R+E+ Sbjct: 296 MNLLS--DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353 Query: 421 ----------------------DLEEAHREKSKGDCTIRDL-------RNEVEKLRNE-- 449 L E +E + + D+ R ++E+L E Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413 Query: 450 ----------------------VNEREKAMENRYKSLLSESNK-------KLHNQEQVIK 480 ++ + E KSL E N+ KL + Q + Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473 Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 E ++ K L++ ++N L ++ +E+ ++ EK S Q Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDL 531 Query: 541 SKEKKQ--------SSDYEELIQVLKKEQDIYTHLVKSLQE------------------- 573 KEK Q + E I++L++E + V SL++ Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591 Query: 574 -SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632 +SI ++L+KI ++Q+++++ Y+ + EE +E+ E+E+ L T+ Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651 Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692 C +K+ L Q EL +N+ LKKT+ + FQ Sbjct: 652 KITC------------------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693 Query: 693 DRLASTEQTELLASKEDEDTIKIGEDDEINF-LSDQHLQQSNEIMK---DLSKGGCKNGY 748 + ++ E L + + +++K L ++ L+ E +K +L K K Sbjct: 694 KENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752 Query: 749 LRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLF 808 + D + LE + L +E L +E++ L K + EL + Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSN--KKIQQLESELQDLEMENQ-TLQKNLEELKISSKR 809 Query: 809 LTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVKAGEVPKVG 867 L + E + L+ +T + K K +L + N + E+K + E VK G + K Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866 Query: 868 LKDASVQTVATEGDLLRFK--HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSL 925 K S + + +R K + +E + I+ R + + Q L Sbjct: 867 -KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925 Query: 926 PGITNREAK----KSRLPILIKPSRSLGNMYRLPATQEVVTQLQS------QILELQGEL 975 +T+ K K RL L + + Y+L ++ T +S +I L+ L Sbjct: 926 EKLTHELEKIGLNKERL--LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983 Query: 976 KEFKTCNKQLHQKLILAEAVMEG--RPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSV 1033 +E N+QL Q+L + E + ++ ++ + PP+ +D+ E++ +TT + Sbjct: 984 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--EDNKWERESQETTREL 1041 Query: 1034 WRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA-TYLSSKSQPSAKV 1092 + K+ + +R+ A+L + K+ + L L ++ + Sbjct: 1042 LKVKDRLIEVERNN------------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089 Query: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHS--QCSEAIITVLCGT 1150 +V +Q+ ++ T N ++ + ++ QN +Q+ S +E++I Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149 Query: 1151 EGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQE 1210 + D L K + +S ++ KH + ++ R LE+ QL +Q+ Sbjct: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209 Query: 1211 YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270 +L+ + + +++ E L+NK + Y L R Q +K+ V+ Sbjct: 1210 GQLEDLEKM-LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE---VLQ 1265 Query: 1271 RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330 H N + LL S ++ E + ++L E+ ++L + + + + Sbjct: 1266 TDHKN-----LKSLLNNSKLEQTRLEA------EFSKLKEQYQQLDITSTKLNNQCELLS 1314 Query: 1331 ELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389 +L +EE+N +HLL + + L + K F +Q+Q Sbjct: 1315 QLKGNLEEEN---RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ------------- 1358 Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEK 1418 ++ + E+R +++LEE I K Sbjct: 1359 -----YIDKLNELRRQKEKLEEKIMDQYK 1382 Score = 63.9 bits (154), Expect = 1e-09 Identities = 248/1346 (18%), Positives = 520/1346 (38%), Gaps = 204/1346 (15%) Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342 +++ F ERIQ L+ D + E ++ + +Q + + S+E +IE Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--------DIE 187 Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402 L A + L + + + + G L A S + + S + Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247 Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462 ++ EL+D + + RL ++LEE + + D + E+E++ E+ K ++ Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIEL----KRLQQENM 296 Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522 +LLS++ ++++ D L +K D + + Y D+E Sbjct: 297 NLLSDARSARMYRDEL-----------DALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345 Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582 + K +Q +KT+ + + + + + L+KE +LQ +++++ Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---------NLQLKAKLHDMEM 396 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 E + RK++E+ L E+ + +++S D++ +L LE+ +R Sbjct: 397 ERDMD---RKKIEE-----------LMEENMTLEMAQKQSM----DESLHLGWELEQISR 438 Query: 643 F-QVEHFSQEELKKKVSDLIQL-VKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700 ++ Q+ L +V++L + +L +NQ L KT+ +L G ++ E+ Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498 Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760 SK+ ++I E++ + Q LQ + KDL K + L T + + Sbjct: 499 ENQRLSKK----VEILENEIVQ--EKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENS 549 Query: 761 GAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820 +E +N +++ + E+R ++ ++L + T ++S Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS----- 604 Query: 821 GKTEKTPKQ-KGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATE 879 K E +Q K EL H+ K+ + E Sbjct: 605 -KIEFEKRQIKKELEHY--------------------------------KEKGERAEELE 631 Query: 880 GDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLP 939 +L + E E ++K N ++ E AL RE +K Sbjct: 632 NELHHLEKE--NELLQKKITNLKITCEKIE-----------ALEQENSELERENRK---- 674 Query: 940 ILIKPSRSLGNM-YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEG 998 L K S N+ ++L + ++ +QL + LEL+ ++ K + ++ Q L L +E Sbjct: 675 -LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELES 732 Query: 999 RPTPDKT---LLNAQ----PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDS 1051 K LL A + +YQ E + ++ T +++ ++ +++S Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT--------LENSNKKIQQLES 784 Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY 1111 E+ DL + + L +S K S + ++ + E + Sbjct: 785 EL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKR 840 Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF 1171 L+Q+ +T LE I L+K ++ I + + L K + +E+ Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-----ENKELV- 894 Query: 1172 SSLHQVRYVKHVKILGPLAPEMIDSRV-LENLKQQLEEQEYKLQK-EQNLNMQLFSEIHN 1229 R +K L L +++ ++ + + LE+ ++L+K N L E Sbjct: 895 -----KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949 Query: 1230 LQNKFRDLSPPRYDSLVQS---QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286 ++++ L +L +S + +++ ++++ RQ + T+ K +E L Q Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009 Query: 1287 ASDVDYCVAEG-------------FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM 1333 D + V QE + ++ ++L ++ N ++ E + Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069 Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393 +++E N Q + + S L + T+ ++ ++ Q +++ S + + + Sbjct: 1070 KQLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127 Query: 1394 LLMEH----------IQEIRTLRKRLEESIKTNEKLRKQLERQGSEF---VQGSTSIFAS 1440 LL++ I+E L+ + IK +EKL ERQ SE+ + ++ ++ Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1187 Query: 1441 GSEL---HSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESLSRKTVSL---- 1491 L H L + L KQ L + ++K ++K +K E+++ + L Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1247 Query: 1492 EHLQREYASVKEENERLQKEGSE-KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN 1550 + L Y+ + +E E LQ + K N +++ R E S+++E+ QQL + Sbjct: 1248 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-EFSKLKEQY---QQLDITS 1303 Query: 1551 DKLLQSLRVELKAYEKLDEEHRRLRD 1576 KL + + L+EE+R L D Sbjct: 1304 TKLNNQCELLSQLKGNLEEENRHLLD 1329 Score = 63.9 bits (154), Expect = 1e-09 Identities = 123/624 (19%), Positives = 259/624 (41%), Gaps = 52/624 (8%) Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL-VQSQARELSLQR 1257 L + KQ+LE+ E +L++ Q NM L S+ + + +L R ++ V E+S + Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333 Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFL 1317 +++ D + + + + + LL+ + EG + + ++ EL ++ +L Sbjct: 334 ERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389 Query: 1318 NGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377 + +E + + +E + E+N+T + +S + S + S S S ++ Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449 Query: 1378 -----NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-------KTNEKLRKQLER 1425 NE + ++ L + ++E+RT +E + K N++L K++E Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509 Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485 +E VQ S+ + L L E L K + L + + ++EN+ L +++S Sbjct: 510 LENEIVQEKQSL-QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568 Query: 1486 ----RKTVSLE----HLQRE----YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533 R +S E +++E + S+KE + +L K EK + ++L + + G+ Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627 Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL-RDGDKYPMESDNSFDL-- 1590 ++ E+ ++ K + +L++ + E L++E+ L R+ K D+ +L Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687 Query: 1591 -FDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVL 1649 +S + + E L N +SL C S A +L + S+ + Sbjct: 688 QLESLEKENSQLDEENLELRRN-VESLKCASMKMA-------QLQLENKELESEKEQLKK 739 Query: 1650 GLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKL 1709 GL E +A K+ + + +DI+ Q + L L + + Sbjct: 740 GL-ELLKASFKKTERLEVSYQGLDIENQR----LQKTLENSNKKIQQLESELQDLEMENQ 794 Query: 1710 TLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQL 1769 TL++ LK +S Q + + + +++ K K+L ++ K+L+ ++ Sbjct: 795 TLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850 Query: 1770 SKRQEKVIFDQLVVTHKILRKARG 1793 + + V L +K L K G Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIG 874 Score = 60.8 bits (146), Expect = 1e-08 Identities = 111/553 (20%), Positives = 219/553 (39%), Gaps = 65/553 (11%) Query: 1067 ENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126 EN + + T + S ++K+ M + E+ S + E L+ +I + L+ Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKM---EKENQRLSKKVEILENEIVQEKQSLQNC 524 Query: 1127 QNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL 1186 QN L K E I L Q + + +N + T SSL Q + Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQIS----- 577 Query: 1187 GPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244 A + EN L + ++E KL K + Q+ E+ + + K Sbjct: 578 ---AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----------- 623 Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304 +A EL + ++ + + Q T +K E ++A +++ ++ Sbjct: 624 --GERAEELENELHHLEKENELL----QKKITNLKITCEKIEA----------LEQENSE 667 Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364 KL+K + K++ ++ + + +++E+NL + + S A E Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727 Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424 E K+ E K S + L Q + +RL+++++ + K +QLE Sbjct: 728 KELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783 Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN---AMLIKGSRDKQKENDKLR 1481 + + + ++ + EL S + + L K+N++L + L K + +KEN +LR Sbjct: 784 SELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842 Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKE----------GSEKERHNQQLIQEVRCSGQ 1531 + K +LE + ++++EN+ L KE E E+ N++L++ + Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902 Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLF 1591 L ++E++ + Q + L+ L EL EK+ RL ++ D+ + L Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHEL---EKIGLNKERLLHDEQ--STDDSRYKLL 957 Query: 1592 DSSQAVTPKSVSE 1604 +S T K E Sbjct: 958 ESKLESTLKKSLE 970 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 115 bits (288), Expect = 4e-25 Identities = 196/896 (21%), Positives = 366/896 (40%), Gaps = 181/896 (20%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E+ + TRAR+ K + EL+KEN LK +++ +E + E + + N+ L++ Sbjct: 364 EDQLEGTRARSDK-----LHELEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEM 417 Query: 109 -EVESLKRELQ---EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164 + +S+ L E EQ+ + S+ E+ ++ G E+ + K++ LTK + Sbjct: 418 AQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476 Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLE----SKLSEMKKMHEGDLAMALVLDEKD 220 L V + + K + + L ++E + E + + ++ EK Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536 Query: 221 RLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE----- 275 +L + ++ ++ E I+ L++E + ++ VSS R +A K+ E E Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARVKDIEKENKILH 593 Query: 276 --------------------AAQMEHQKERNSFEERIQALEEDLR--EKEREI------- 306 ++EH KE+ ER + LE +L EKE E+ Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEELENELHHLEKENELLQKKITN 650 Query: 307 ---------ATEKKNS-LKRDK--------AIQGLTMALKSKEKKVEELNSE-------I 341 A E++NS L+R+ + + LT L+S EK+ +L+ E + Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710 Query: 342 EKLSAAFAKAREA------LQKAQTQEFQGSEDYETALSGKEALSAA-----LRSQNLTK 390 E L A K + L+ + Q +G E + + E L + + +Q L K Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770 Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450 + EN + I+++ EL DL+ E + L+K+LEE + + L E + L E Sbjct: 771 TLENSN--KKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQET 824 Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE---KDLEVIQQN 507 ++ EK K L + NK+L Q ++ E N K L+K N+ K++ + +++ Sbjct: 825 SQLEKD-----KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879 Query: 508 CYLMAAEDLELRS----------------EGLITEKCSSQQPPGSKTIFSKE-KKQSSDY 550 C + + E + E L++EK +QQ + E +K + Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939 Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---KT 607 E L+ + D Y L++S ES +L+ + KI AL +LE+ Q LR KT Sbjct: 940 ERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998 Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQL---- 663 +++ +++R++E + S I E+N + + EL K LI++ Sbjct: 999 VKKNYEALKQRQDEERMVQSSP----PISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054 Query: 664 -------------VKELYTDNQHLKKTIFDL--SCMGFQGNG-----------FPDRLAS 697 +K+L T N +L+ I L + Q + + Sbjct: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1114 Query: 698 TEQTELL----------ASKEDEDTIKIGEDDEINFLSDQ-----------HLQQSNEIM 736 ++ T L+ +S E+E+ I E +++ L D H +Q++E Sbjct: 1115 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174 Query: 737 KDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792 +SK G ++ E + D + + ++G +L L E+ +LLE++ Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230 Score = 107 bits (267), Expect = 1e-22 Identities = 321/1466 (21%), Positives = 572/1466 (39%), Gaps = 241/1466 (16%) Query: 40 GNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHI 99 G LP+ S SP + MK E++ L E + K +I R++QE TE + Sbjct: 220 GLHFLPHASSSAQSPCGSPGMKRTESR-QHLSVELADAKAKI----RRLRQELEEKTEQL 274 Query: 100 YKTNIELKVEVESLKRELQEREQLLIKASKA------VESLAEAG------GSEIQRVKE 147 EL+ LKR QE LL A A +++L E SE+ R KE Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE 334 Query: 148 ---DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK- 203 D +VE+L +LLE + LE GT LE + ++K Sbjct: 335 RLHDIEFYKARVEELKEDNQVLLE-----TKTMLEDQLEGTRARSDKLHELEKENLQLKA 389 Query: 204 KMHEGDLAMALVLDEKDRLIEE-LKLSLKSKEALIQCLK--EEKSQMACPDENVSSGELR 260 K+H+ ++ + + + L+EE + L + K+++ + L E Q++ E +S + Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-LSEAPQK 448 Query: 261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNS--LKRDK 318 L E +ME+Q + EE ++ + + EK+N K+ + Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508 Query: 319 AIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ-------KAQTQEFQGSEDYET 371 ++ + K + + L+ ++ K A K E L+ K QE + + Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568 Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSK 431 +L + +SA R +++ K EN L SIK+ + +LS ++ E+ +++K+LE K K Sbjct: 569 SLRQRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELE---HYKEK 623 Query: 432 GDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--LSESNKKLHNQEQVIKHLTESTNQK 489 G+ E+L NE++ EK E K + L + +K+ EQ L + Sbjct: 624 GE--------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675 Query: 490 DVLLQKFNEK--DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547 L F LE +++ + E+LELR + + KC+S + ++ + ++ Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELR-RNVESLKCASMK-------MAQLQLEN 727 Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT 607 + E + LKK ++ L+A K L + + Q L+KT Sbjct: 728 KELESEKEQLKKGLEL----------------LKASFKKTERLEVSYQGLDIENQRLQKT 771 Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667 LE +I++ E E L + + L LEE ++ E+L+K+ L Q +L Sbjct: 772 LENSNKKIQQLESELQDLEMENQT-LQKNLEE---LKISSKRLEQLEKENKSLEQETSQL 827 Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727 D + L+K + +Q E+ + +E+ +KIG Sbjct: 828 EKDKKQLEK----------------ENKRLRQQAEIKDTTLEENNVKIG----------- 860 Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787 +L++ N K LSK G + C+ L L E L Sbjct: 861 NLEKEN---KTLSKE-----------------IGIYKESCVR-------LKELEKENKEL 893 Query: 788 LLESRPDL--LKVVRELLLGQLFLTEQEVSG-EHLDGKTEKTPKQKGELVHFVQTNSFSK 844 + + D+ L +RE L+ + T+Q + E L + EK K L+H Q S Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ--STDD 951 Query: 845 PHDELKLSCEAQLVKAGEV--PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTA 902 + L+ E+ L K+ E+ K+ +A ++ LR + + ++ +E A Sbjct: 952 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE------A 1005 Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSR-----LPILIKPSRSLGNMYRLPAT 957 L E + + S P I+ + K R L+K L + R AT Sbjct: 1006 LKQRQDEERM---------VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056 Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQPPVGA 1015 LQ++ L+ +LK+ +T N L +++ + + TL NA+ V Sbjct: 1057 ------LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110 Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE--ICPPDDLASLPSCKENPEDVL 1073 + +S ++S+ QQ S E ++E I +DL SL + L Sbjct: 1111 STLNS--------QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1162 Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE--------TEYLKQK--IHDLETEL 1123 + S+ + +S GT +S N E + LKQK + DLE L Sbjct: 1163 E----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1218 Query: 1124 EGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSL---HQVRYV 1180 + Q + K+ + A LCG +D T+S L +V Sbjct: 1219 KVEQEKMLLENKNHETVAAEYKKLCGE-------------NDRLNHTYSQLLKETEVLQT 1265 Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL---QKEQNLNMQLFSEIH-NLQNKFRD 1236 H + L ++ LE +L+EQ +L + N +L S++ NL+ + R Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325 Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTM--IKAFEELLQASDVDYCV 1294 L D + + +L Q ++ V RQ+++ + ++ +E L+ +D Sbjct: 1326 L----LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381 Query: 1295 AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPS 1354 + + K+ KL + K + E L + + + L + + S Sbjct: 1382 FYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDS 1441 Query: 1355 A---SHALSDYET--SEKSF--------FSRDQKQDNETEKT----SVMVNSFSQDLLME 1397 + S++L D +T ++KS F R++ +D + K S+ +N Q +++ Sbjct: 1442 SSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLA 1501 Query: 1398 HIQEIRTLRKRLEESIKTNEKLRKQL 1423 T + + I T K RK+L Sbjct: 1502 GQWTGSTENLEVPDDISTG-KRRKEL 1526 Score = 69.3 bits (168), Expect = 3e-11 Identities = 260/1409 (18%), Positives = 534/1409 (37%), Gaps = 242/1409 (17%) Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201 ++++K ++ +QQ+ + +L++ K+ + Q GTE K L L L Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQ--------GTEEVKKLLLLL------ 128 Query: 202 MKKMHEGDLAMALVLDEKDRLIEELK-LSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260 L A+ +K+ IE ++ L +K A+ ++E ENV + Sbjct: 129 --------LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQ----ENVFDLQWM 176 Query: 261 GLCAAPREEKERETEAAQMEHQK---ERNSFEERIQALEEDLREKEREIATEKKNS---- 313 + +E+ E + + ++ ER+ E I L E+ R+ + ++ Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEE-RDGLHFLPHASSSAQSPC 235 Query: 314 ----LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369 +KR ++ Q L++ L + K+ L E+E+ + ++ L++ + + + ++ Sbjct: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295 Query: 370 ETALSGKEALSAALRSQNL----TKSTENHRLRRSIKKITQELSDLQQERERLEK----- 420 LS +A SA + L K+ +L + + + L D++ + R+E+ Sbjct: 296 MNLLS--DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353 Query: 421 ----------------------DLEEAHREKSKGDCTIRDL-------RNEVEKLRNE-- 449 L E +E + + D+ R ++E+L E Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413 Query: 450 ----------------------VNEREKAMENRYKSLLSESNK-------KLHNQEQVIK 480 ++ + E KSL E N+ KL + Q + Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473 Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 E ++ K L++ ++N L ++ +E+ ++ EK S Q Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDL 531 Query: 541 SKEKKQ--------SSDYEELIQVLKKEQDIYTHLVKSLQE------------------- 573 KEK Q + E I++L++E + V SL++ Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591 Query: 574 -SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632 +SI ++L+KI ++Q+++++ Y+ + EE +E+ E+E+ L T+ Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651 Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692 C +K+ L Q EL +N+ LKKT+ + FQ Sbjct: 652 KITC------------------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693 Query: 693 DRLASTEQTELLASKEDEDTIKIGEDDEINF-LSDQHLQQSNEIMK---DLSKGGCKNGY 748 + ++ E L + + +++K L ++ L+ E +K +L K K Sbjct: 694 KENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752 Query: 749 LRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLF 808 + D + LE + L +E L +E++ L K + EL + Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSN--KKIQQLESELQDLEMENQ-TLQKNLEELKISSKR 809 Query: 809 LTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVKAGEVPKVG 867 L + E + L+ +T + K K +L + N + E+K + E VK G + K Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866 Query: 868 LKDASVQTVATEGDLLRFK--HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSL 925 K S + + +R K + +E + I+ R + + Q L Sbjct: 867 -KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925 Query: 926 PGITNREAK----KSRLPILIKPSRSLGNMYRLPATQEVVTQLQS------QILELQGEL 975 +T+ K K R L+ +S + Y+L ++ T +S +I L+ L Sbjct: 926 EKLTHELEKIGLNKER---LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982 Query: 976 KEFKTCNKQLHQKLILAEAVMEG--RPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSV 1033 +E N+QL Q+L + E + ++ ++ + PP+ +D+ E++ +TT + Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--EDNKWERESQETTREL 1040 Query: 1034 WRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA-TYLSSKSQPSAKV 1092 + K+ + +R+ A+L + K+ + L L ++ + Sbjct: 1041 LKVKDRLIEVERNN------------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088 Query: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHS--QCSEAIITVLCGT 1150 +V +Q+ ++ T N ++ + ++ QN +Q+ S +E++I Sbjct: 1089 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148 Query: 1151 EGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQE 1210 + D L K + +S ++ KH + ++ R LE+ QL +Q+ Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208 Query: 1211 YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270 +L+ + + +++ E L+NK + Y L R Q +K+ V+ Sbjct: 1209 GQLEDLEKM-LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE---VLQ 1264 Query: 1271 RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330 H N + LL S ++ E + ++L E+ ++L + + + + Sbjct: 1265 TDHKN-----LKSLLNNSKLEQTRLEA------EFSKLKEQYQQLDITSTKLNNQCELLS 1313 Query: 1331 ELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389 +L +EE+N +HLL + + L + K F +Q+Q Sbjct: 1314 QLKGNLEEEN---RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ------------- 1357 Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEK 1418 ++ + E+R +++LEE I K Sbjct: 1358 -----YIDKLNELRRQKEKLEEKIMDQYK 1381 Score = 68.6 bits (166), Expect = 5e-11 Identities = 123/582 (21%), Positives = 239/582 (41%), Gaps = 79/582 (13%) Query: 1030 TSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS 1089 ++ ++RD E+D+ ++++ +D + + KE D+ + L +Q Sbjct: 304 SARMYRD-ELDALREKAVRVDKLE------SEVSRYKERLHDIEFYKARVEELKEDNQVL 356 Query: 1090 AKVSVMGTDQSESINTSN--------ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141 + M DQ E + E LK K+HD+E E + + I +L + + E Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416 Query: 1142 AI------ITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID 1195 ++ G E Q +S+ S+ + + H+V + ++L Sbjct: 417 MAQKQSMDESLHLGWELEQ--ISRTSELSEAPQKSLG--HEVNELTSSRLLKLEMENQSL 472 Query: 1196 SRVLENLKQQLEEQE---YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARE 1252 ++ +E L+ ++ E K+ K + N +L ++ L+N E Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN-------------------E 513 Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312 + ++Q +++ + + + K E L + S+ + E E LNQ L + Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573 Query: 1313 EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSR 1372 ++ + +E + L E I+E + + E + L Y+ EK R Sbjct: 574 SQISAEARVKDIEKENK-ILHESIKETSSKLSKI--EFEKRQIKKELEHYK--EKG--ER 626 Query: 1373 DQKQDNE---TEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSE 1429 ++ +NE EK + ++ +L + ++I L + E + N KL+K L+ Sbjct: 627 AEELENELHHLEKENELLQKKITNLKIT-CEKIEALEQENSELERENRKLKKTLDS---- 681 Query: 1430 FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN------AMLIKGSRDKQKENDKLRES 1483 + T S + +S L E LR+ ++L A L +++ + E ++L++ Sbjct: 682 -FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740 Query: 1484 LSRKTVSL---EHLQREYASVKEENERLQKEGSEKERHNQQL---IQEVRCSGQELSRVQ 1537 L S E L+ Y + EN+RLQK + QQL +Q++ Q L + Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800 Query: 1538 EEVKLRQQLLSQNDKLLQSLRVELKAYEK----LDEEHRRLR 1575 EE+K+ + L Q +K +SL E EK L++E++RLR Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842 Score = 65.9 bits (159), Expect = 4e-10 Identities = 246/1345 (18%), Positives = 521/1345 (38%), Gaps = 203/1345 (15%) Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342 +++ F ERIQ L+ D + E ++ + +Q + + S+E +IE Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--------DIE 187 Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402 L A + L + + + + G L A S + + S + Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247 Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462 ++ EL+D + + RL ++LEE + + D + E+E++ E+ K ++ Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIEL----KRLQQENM 296 Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522 +LLS++ ++++ D L +K D + + Y D+E Sbjct: 297 NLLSDARSARMYRDEL-----------DALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345 Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582 + K +Q +KT+ + + + + + L+KE +LQ +++++ Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---------NLQLKAKLHDMEM 396 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 E + RK++E+ L E+ + +++S D++ +L LE+ +R Sbjct: 397 ERDMD---RKKIEE-----------LMEENMTLEMAQKQSM----DESLHLGWELEQISR 438 Query: 643 F-QVEHFSQEELKKKVSDLIQL-VKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700 ++ Q+ L +V++L + +L +NQ L KT+ +L G ++ E+ Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498 Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760 SK+ ++I E++ + Q LQ + KDL K + L T + + Sbjct: 499 ENQRLSKK----VEILENEIVQ--EKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENS 549 Query: 761 GAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820 +E +N +++ + E+R ++ ++L + T ++S Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS----- 604 Query: 821 GKTEKTPKQ-KGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATE 879 K E +Q K EL H+ K+ + E Sbjct: 605 -KIEFEKRQIKKELEHY--------------------------------KEKGERAEELE 631 Query: 880 GDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLP 939 +L + E E ++K N ++ E AL RE +K Sbjct: 632 NELHHLEKE--NELLQKKITNLKITCEKIE-----------ALEQENSELERENRK---- 674 Query: 940 ILIKPSRSLGNM-YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEG 998 L K S N+ ++L + ++ +QL + LEL+ ++ K + ++ Q L L +E Sbjct: 675 -LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELES 732 Query: 999 RPTPDKT---LLNAQ----PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDS 1051 K LL A + +YQ E + ++ T +++ ++ +++S Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT--------LENSNKKIQQLES 784 Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY 1111 E+ DL + + L +S K S + ++ + E + Sbjct: 785 EL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKR 840 Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF 1171 L+Q+ +T LE I L+K ++ I + + L K + +E+ Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-----ENKELV- 894 Query: 1172 SSLHQVRYVKHVKILGPLAPEMIDSRV-LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNL 1230 R +K L L +++ ++ + + LE+ ++L+K +L + + Sbjct: 895 -----KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949 Query: 1231 QNKFRDLSPPRYDSLVQS---QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA 1287 ++++ L +L +S + +++ ++++ RQ + T+ K +E L Q Sbjct: 950 DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009 Query: 1288 SDVDYCVAEG-------------FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELME 1334 D + V QE + ++ ++L ++ N ++ E ++ Sbjct: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069 Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL 1394 ++E N Q + + S L + T+ ++ ++ Q +++ S + + + L Sbjct: 1070 QLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127 Query: 1395 LMEH----------IQEIRTLRKRLEESIKTNEKLRKQLERQGSEF---VQGSTSIFASG 1441 L++ I+E L+ + IK +EKL ERQ SE+ + ++ ++ Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187 Query: 1442 SEL---HSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESLSRKTVSL----E 1492 L H L + L KQ L + ++K ++K +K E+++ + L + Sbjct: 1188 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND 1247 Query: 1493 HLQREYASVKEENERLQKEGSE-KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQND 1551 L Y+ + +E E LQ + K N +++ R E S+++E+ QQL + Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-EFSKLKEQY---QQLDITST 1303 Query: 1552 KLLQSLRVELKAYEKLDEEHRRLRD 1576 KL + + L+EE+R L D Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLD 1328 Score = 63.9 bits (154), Expect = 1e-09 Identities = 123/624 (19%), Positives = 259/624 (41%), Gaps = 52/624 (8%) Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL-VQSQARELSLQR 1257 L + KQ+LE+ E +L++ Q NM L S+ + + +L R ++ V E+S + Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333 Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFL 1317 +++ D + + + + + LL+ + EG + + ++ EL ++ +L Sbjct: 334 ERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389 Query: 1318 NGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377 + +E + + +E + E+N+T + +S + S + S S S ++ Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449 Query: 1378 -----NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-------KTNEKLRKQLER 1425 NE + ++ L + ++E+RT +E + K N++L K++E Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509 Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485 +E VQ S+ + L L E L K + L + + ++EN+ L +++S Sbjct: 510 LENEIVQEKQSL-QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568 Query: 1486 ----RKTVSLE----HLQRE----YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533 R +S E +++E + S+KE + +L K EK + ++L + + G+ Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627 Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL-RDGDKYPMESDNSFDL-- 1590 ++ E+ ++ K + +L++ + E L++E+ L R+ K D+ +L Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687 Query: 1591 -FDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVL 1649 +S + + E L N +SL C S A +L + S+ + Sbjct: 688 QLESLEKENSQLDEENLELRRN-VESLKCASMKMA-------QLQLENKELESEKEQLKK 739 Query: 1650 GLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKL 1709 GL E +A K+ + + +DI+ Q + L L + + Sbjct: 740 GL-ELLKASFKKTERLEVSYQGLDIENQR----LQKTLENSNKKIQQLESELQDLEMENQ 794 Query: 1710 TLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQL 1769 TL++ LK +S Q + + + +++ K K+L ++ K+L+ ++ Sbjct: 795 TLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850 Query: 1770 SKRQEKVIFDQLVVTHKILRKARG 1793 + + V L +K L K G Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIG 874 Score = 61.6 bits (148), Expect = 7e-09 Identities = 111/553 (20%), Positives = 220/553 (39%), Gaps = 66/553 (11%) Query: 1067 ENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126 EN + + T + S ++K+ M + E+ S + E L+ +I + L+ Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKM---EKENQRLSKKVEILENEIVQEKQSLQNC 524 Query: 1127 QNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL 1186 QN L K E I L Q + + +N + T SSL Q + Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQIS----- 577 Query: 1187 GPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244 A + EN L + ++E KL K + Q+ E+ + + K Sbjct: 578 ---AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----------- 623 Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304 +A EL + ++ + + Q T +K E ++A +++ ++ Sbjct: 624 --GERAEELENELHHLEKENELL----QKKITNLKITCEKIEA----------LEQENSE 667 Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364 KL+K + K++ ++ + + +++E+NL + + S A E Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727 Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424 E K+ E K S + L Q + +RL+++++ + K +QLE Sbjct: 728 KELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783 Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN---AMLIKGSRDKQKENDKLR 1481 + + + ++ + EL S + + L K+N++L + L K + +KEN +LR Sbjct: 784 SELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842 Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKE----------GSEKERHNQQLIQEVRCSGQ 1531 + K +LE + ++++EN+ L KE E E+ N++L++ + Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902 Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLF 1591 L ++E++ + Q + L+ L EL EK+ RL ++ +D+ + L Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHEL---EKIGLNKERLLHDEQ---STDDRYKLL 956 Query: 1592 DSSQAVTPKSVSE 1604 +S T K E Sbjct: 957 ESKLESTLKKSLE 969 >gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] Length = 1088 Score = 113 bits (283), Expect = 1e-24 Identities = 146/740 (19%), Positives = 303/740 (40%), Gaps = 124/740 (16%) Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQ---QEFHGPTEHI--YKTNIE--------LK 107 K +N+I ++K+E + L+ +++ +F +HI K ++ L+ Sbjct: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493 Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167 EV++L+ L+E+E +L K +K ++ +AE G++ + + ++ + D+ +++ +L Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD-----LKDMLDVKERKVNVL 548 Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK 227 +K + Q +L + EK + S L E K + D D + L+ Sbjct: 549 QKKIENLQEQLR------DKEKQM-----SSLKERVKSLQADTT------NTDTALTTLE 591 Query: 228 LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS 287 +L KE I+ LKE++ R+E+E++ E ++K+ Sbjct: 592 EALAEKERTIERLKEQRD---------------------RDEREKQEEIDN--YKKDLKD 628 Query: 288 FEERIQALEEDLREKEREIATEKKNS-------LKRDKAIQGLTMALKSKEKKVEELNSE 340 +E++ L+ DL EKE + K+++ LK+D ++ L +AL+ K+++ ++ S+ Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688 Query: 341 IEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRS 400 ++K +E AL + + + R Q+L R Sbjct: 689 LKKA------------------------HEAALEARASPEMSDRIQHL---------ERE 715 Query: 401 IKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV---NEREKAM 457 I + E S Q E +RL + L+E EK+ D I +L +V+ +V +E+ Sbjct: 716 ITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775 Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ----QNCYLMAA 513 + + +L E+ ++ N + L +S +KD +++ E E +Q + L Sbjct: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835 Query: 514 EDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE 573 E +E + E + + + + S + K SS + L + KE + + + Sbjct: 836 ESARTNAEKQVEELLMAMEKV-KQELESMKAKLSSTQQSLAE---KETHLTNLRAERRKH 891 Query: 574 SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633 + + ++ E K +L + +K +E+++ ++R ++ QT Sbjct: 892 LEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNR 951 Query: 634 SICLEEN---NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690 + +N + F+ H +Q K +IQ + EL + LK I L+ Sbjct: 952 MKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTT------- 1004 Query: 691 FPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLR 750 L +L + + +DD+ + ++ ++ +L KG N L+ Sbjct: 1005 ----LCHDRDPLILRGLTPPASYNL-DDDQAAWENELQKMTRGQLQDELEKGERDNAELQ 1059 Query: 751 HTESKISDCDGAHAPGCLEE 770 + I H P LE+ Sbjct: 1060 EFANAILQQIADHCPDILEQ 1079 Score = 70.9 bits (172), Expect = 1e-11 Identities = 131/684 (19%), Positives = 292/684 (42%), Gaps = 101/684 (14%) Query: 127 ASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTE 186 AS SL +A + I ++ K+V + DLL K + + E ++++ + K F E Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQL-KEVLRENDLLRKDVEVKESKLSSSMNSI-KTFWSPE 193 Query: 187 T--EKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEK 244 E+ALR SK++ K+ + V+ E++ + +++++++ + ++ ++ + Sbjct: 194 LKKERALRKDEASKITIWKEQYR-------VVQEEN---QHMQMTIQALQDELR-IQRDL 242 Query: 245 SQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER 304 +Q+ D + +GE C A E E + EH+++ + + L + L E E Sbjct: 243 NQLFQQDSSSRTGEP---CVA--ELTEENFQRLHAEHERQA----KELFLLRKTLEEMEL 293 Query: 305 EIATEKKNSLKRDKAIQGLTMALKSK---EKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 I T+K+ RD++I+ L L+SK K EE + +L+ A + + Sbjct: 294 RIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353 Query: 362 EFQGS-------EDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 E + S +E A A + AL++ K ++ + R ++ + +E+ L+ Sbjct: 354 EKENSMLREEMHRRFENA--PDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN 411 Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK---AMENRYKSLLSE-SNK 470 ++ EE ++ + ++N++ +++ E++ ++ A++ + ++L ++ S+ Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS 471 Query: 471 KLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR---SEGLITEK 527 K H +V+K + Q+ +LQ + L LR E ++ +K Sbjct: 472 KQH--IEVLKESLTAKEQRAAILQ----------------TEVDALRLRLEEKETMLNKK 513 Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKI 587 Q + + + D ++++ V +++ ++ +++LQE + + + +++ + Sbjct: 514 TKQIQDMAEEK--GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE--QLRDKEKQMSSL 569 Query: 588 FALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEH 647 K L+ D + TLEE ++E R E + R + E Sbjct: 570 KERVKSLQADTTNTDTALTTLEEALAEKERTIERL----------------KEQRDRDER 613 Query: 648 FSQEEL---KKKVSDLIQLVKELYTDNQHLKKTIFDL----SCMGFQGNGFPDRLASTEQ 700 QEE+ KK + DL + V L D + ++ DL S + G RL + Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL---KT 670 Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760 E+ ++ E+ +K+ + L++++E + + ++H E +I+ Sbjct: 671 LEIALEQKKEECLKM----------ESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720 Query: 761 GAHAPGCLEEGAFINLLAPLFNEK 784 + E + +L + NEK Sbjct: 721 DESSKAQAEVDRLLEILKEVENEK 744 Score = 45.8 bits (107), Expect = 4e-04 Identities = 101/475 (21%), Positives = 185/475 (38%), Gaps = 68/475 (14%) Query: 1108 ETEYLKQKIHDLETELEGYQ--NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSD 1165 E ++++ I L+ EL + N +FQ S+ E + L Sbjct: 221 ENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT----------------- 263 Query: 1166 GEEMTFSSLH--QVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQK------EQ 1217 E F LH R K + +L EM +E KQ L ++ ++K + Sbjct: 264 --EENFQRLHAEHERQAKELFLLRKTLEEM--ELRIETQKQTLNARDESIKKLLEMLQSK 319 Query: 1218 NLNMQLFSEIHNLQNKFRD--LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275 L+ + E H + + + +SL++ + +E S+ R+++ + Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR-----FENAPDS 374 Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER 1335 KA + +++ D E +L E+++ L NG E + + ME Sbjct: 375 AKTKALQTVIEMKDSKISSME------RGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428 Query: 1336 IEEDNLTYQHLLPE-----SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSF 1390 + ++ + + S + + AL + + FS D KQ E K S+ Sbjct: 429 YRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFS-DSKQHIEVLKESLTAKEQ 487 Query: 1391 SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450 +L E+ LR RLEE K KQ++ E + I ++ Sbjct: 488 RAAILQT---EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH-DLKDMLDVKER 543 Query: 1451 EIHFLRKQNQALNAMLIKGSRDKQKENDKLRE---SLSRKT----VSLEHLQREYASVKE 1503 +++ L+K+ + L L RDK+K+ L+E SL T +L L+ A + Sbjct: 544 KVNVLQKKIENLQEQL----RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER 599 Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558 ERL+++ ER Q+ I + ++L ++E+V L Q LS+ + L L+ Sbjct: 600 TIERLKEQRDRDEREKQEEIDNYK---KDLKDLKEKVSLLQGDLSEKEASLLDLK 651 Score = 41.2 bits (95), Expect = 0.009 Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 45/397 (11%) Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 +ENL++QL ++E ++ + L ++ N L ++L + + L+ Q Sbjct: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE----EALAEKERTIERLKEQ 607 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 + +D R+ + ++L + + E+ +L E L + Sbjct: 608 RDRD-------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660 Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD-QKQD 1377 G + T +E+ +E+ L + L ++ E + S + R+ + Sbjct: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720 Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRK-------RLEESIK------TNEKLRKQLE 1424 +E+ K V D L+E ++E+ + LE +K N K ++Q+E Sbjct: 721 DESSKAQAEV-----DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775 Query: 1425 RQGS-----EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN-AMLIKGSRDKQKEND 1478 ++ S E + ++ S +L SL + + + +AL ++ I R+ + Sbjct: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835 Query: 1479 KLRESLSRKTV-----SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533 + + + K V ++E +++E S+K + Q+ +EKE H L E R +E+ Sbjct: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895 Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570 +++E L +S+ D + L EL + +K +E Sbjct: 896 LEMKQEALL--AAISEKDANIALL--ELSSSKKKTQE 928 Score = 38.9 bits (89), Expect = 0.046 Identities = 51/219 (23%), Positives = 94/219 (42%), Gaps = 35/219 (15%) Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445 M ++ L I L+ +L+E ++ N+ LRK +E + S+ SI Sbjct: 135 MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI----KTFW 190 Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505 S + LRK + + + R Q+EN ++ ++++ LQ E ++ N Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-------MTIQALQDELRIQRDLN 243 Query: 1506 ERLQKEGSEK----------ERHNQQLIQEVRCSGQEL---SRVQEEVKLR----QQLLS 1548 + Q++ S + E + Q+L E +EL + EE++LR +Q L+ Sbjct: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303 Query: 1549 QNDK-------LLQSLRVELKAYEKLDEEHRRLRDGDKY 1580 D+ +LQS + KA E+ E RRL + + + Sbjct: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH 342 Score = 38.9 bits (89), Expect = 0.046 Identities = 57/263 (21%), Positives = 112/263 (42%), Gaps = 26/263 (9%) Query: 1326 MNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---ETEK 1382 M+ Q +L E + E++L + + E E S +++ S K+F+S + K++ + E Sbjct: 152 MDLQTQLKEVLRENDLLRKDV--EVKESKLSSSMN----SIKTFWSPELKKERALRKDEA 205 Query: 1383 TSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGS 1442 + + + ++ E Q ++ + L++ ++ L QL +Q S G + Sbjct: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-QLFQQDSSSRTGEPCVAELTE 264 Query: 1443 EL-------HSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495 E H E+ LRK + + + + QK+ R+ +K + + + Sbjct: 265 ENFQRLHAEHERQAKELFLLRKTLEEMELRI-----ETQKQTLNARDESIKKLLEMLQSK 319 Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLL--SQNDKL 1553 A EE+ + +E E H L + +E S ++EE+ R + S K Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379 Query: 1554 LQSLRVELKAYEKLDEEHRRLRD 1576 LQ++ +E+K K+ R LRD Sbjct: 380 LQTV-IEMKD-SKISSMERGLRD 400 Score = 38.5 bits (88), Expect = 0.060 Identities = 77/448 (17%), Positives = 183/448 (40%), Gaps = 33/448 (7%) Query: 1096 GTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKH-SQCSEAIITVLCGTEGAQ 1154 GT E + + + ++K++ L+ ++E Q + +K S E + ++ T Sbjct: 525 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584 Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDS--RVLENLKQQLEEQEYK 1212 L+ + +E T L + R + E ID+ + L++LK+++ + Sbjct: 585 TALTTLEEALAEKERTIERLKEQRDRDERE-----KQEEIDNYKKDLKDLKEKVSLLQGD 639 Query: 1213 LQKEQNLNMQLFSEIHNLQNKF--RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270 L +++ + L +L + +D + ++ + E Q+K H + + Sbjct: 640 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 699 Query: 1271 RQ--HMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGV--- 1324 R M+ I+ E E+ + D + Q ++++ E+L+++E N K + Sbjct: 700 RASPEMSDRIQHLEREITRYKDE----SSKAQAEVDRLLEILKEVENE-KNDKDKKIAEL 754 Query: 1325 --EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---- 1378 ++ QN+ + ++ + + E + + ++S++ S +K D Sbjct: 755 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814 Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437 E + SV + + + +L + K++EE + EK++++LE ++ S+ Sbjct: 815 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 874 Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497 + L + L + + L+ +K L S S+K Q E Sbjct: 875 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT-----QEE 929 Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQE 1525 A++K E +RL ++ ++ ++ +L+ + Sbjct: 930 VAALKREKDRLVQQLKQQTQNRMKLMAD 957 >gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 [Homo sapiens] Length = 3259 Score = 113 bits (283), Expect = 1e-24 Identities = 374/1895 (19%), Positives = 744/1895 (39%), Gaps = 339/1895 (17%) Query: 65 NQITELKKENFNLKLRIYFLEERMQQEFHGPTEH-------IYKTNIELK---VEVESLK 114 + +TEL+ + L++ + E + + ++ T H I+ +IE K V++E L+ Sbjct: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ 816 Query: 115 RELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAA 174 EL + + + S + SL S++Q + + + ++V + +K Sbjct: 817 NELDDVQLQFSEQSTLIRSLQ----SQLQNKESEVLEGAERVRHISSK------------ 860 Query: 175 QAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKE 234 EL +A + E E +++ L E K+ E + ++EKD+ + E+ S+ K Sbjct: 861 VEELSQALSQKELEIT---KMDQLLLEKKRDVE---TLQQTIEEKDQQVTEISFSMTEK- 913 Query: 235 ALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294 ++Q L EEK + + + +L L A +KE+ E ++ ++N ++E A Sbjct: 914 -MVQ-LNEEKFSLGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSSGLKQN-YDEMSPA 969 Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKA--- 351 + E + E KK + +R + +Q + K ++V L E+ L K Sbjct: 970 GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPL 1029 Query: 352 --------------REALQKAQTQEFQGSEDY-ETALSGKEALSAALRSQNLTKSTENHR 396 +E +K T + Q E Y + +S KE +R K + Sbjct: 1030 SETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089 Query: 397 LRRSIKKITQELSDLQQERERLEKDLEE----------AHREKSKGDCTIRDLRNEV--- 443 + +K++ Q L D + + L+ ++ E ++ + S GD V Sbjct: 1090 FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISP 1149 Query: 444 ------EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK-------HLTESTNQK- 489 E + E+ E+ A+E + L + + L +++ ++K HL E Q+ Sbjct: 1150 PCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQK 1209 Query: 490 ---DVLLQKFNEKDLE-------VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539 + L ++F+E+ E + Q + + D +L S E CSS PG + Sbjct: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ-QESCSST--PGLEEP 1266 Query: 540 FSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL 599 K +Q L L + ++ +LQ S+ ++A+L +I A + +LE V Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326 Query: 600 SYQNLRKTLEEQISEIRRR------EEESFSLYSDQTSYLSICLE---ENNRFQV---EH 647 S + E++ +++ + E ES S + + L+ E+++ Q+ EH Sbjct: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH 1386 Query: 648 FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASK 707 EL+ K+ +L +L+ + D +L + + + + QTE++ Sbjct: 1387 L--RELQPKLDELQKLISKKEEDVSYLSGQLSE-----------KEAALTKIQTEII--- 1430 Query: 708 EDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGC 767 E ED IK ++ + ++ +E +K L C+ ++ +I + A Sbjct: 1431 EQEDLIKA-----LHTQLEMQAKEHDERIKQLQVELCE---MKQKPEEIGEESRA----- 1477 Query: 768 LEEGAFINLLAPLFNEKATLL----LESRPDLLKVVRELLLGQLFLTEQEVSGEHLD--- 820 ++ L A L + K L L+ L + E L L E +VS ++ + Sbjct: 1478 -KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536 Query: 821 --GKTEKTPKQKGELV-----HFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASV 873 G+ +++ +L+ ++ S S + LKL+ E GL + Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE------------GLTEDKE 1584 Query: 874 QTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREA 933 + V E + L+ A W+EK + L E+ + L S ++N Sbjct: 1585 KLVK-EIESLKSSKIAESTEWQEK--HKELQKEY-----------EILLQSYENVSNEAE 1630 Query: 934 KKSRLPILIKPSRSLGNMY-RLPATQEVVTQLQSQILELQGELKEFKT----CNKQLHQK 988 + + ++ + +Y +L +T+ + + Q+ E + E++E K K QK Sbjct: 1631 RIQHVVEAVRQEKQ--ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQK 1688 Query: 989 LILAEAV-----MEGRPTPD------KTLLNAQPPVGAAYQDSPGEQKGI-KTTSSVWRD 1036 ++ E E P D +TLL++ + + E + + K S+ + Sbjct: 1689 ILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748 Query: 1037 KEMDSD--QQRSYEIDSEICPPDDLASLPS-------CKENPEDVLSPTSVATYLSSKSQ 1087 K+ S+ Q ++I+ + +L + +E + + T LS ++ Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR 1808 Query: 1088 PSAKVSVMGTDQ-----SESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEA 1142 P+ SV S+ ++ +E Q+I L+ + G + + QK+ + S+ Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE---EKQKNKEFSQT 1865 Query: 1143 IITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENL 1202 + E ++ L + DGE V + +L E + SRV + L Sbjct: 1866 L-------ENEKNTLLSQISTKDGELKMLQE-----EVTKMNLLNQQIQEEL-SRVTK-L 1911 Query: 1203 KQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRY-DSLVQSQARELSLQRQQIK 1261 K+ EE++ L E+ L QL ++ N +D++ + + L++S+ + L +++ Sbjct: 1912 KETAEEEKDDL--EERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969 Query: 1262 DGHGICVISRQHMNTMI-KAFEELLQ-----------ASDVDYCVAEGFQE--QLNQ-CA 1306 + V + + + I K + E +Q A ++ + E QE QL + C Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029 Query: 1307 ELLEKLEKLFLNGKSVG-VEMNTQNELMERIEEDNLTY--QHLLPESPEPSASHALSDYE 1363 EK+ L K++ V+ +Q +L I ++NL +H E ++ L D Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDL--EITKENLAQAVEHRKKAQAELASFKVLLDDT 2087 Query: 1364 TSEKSFFSRDQ---KQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLR 1420 SE + D K++ ++ K SV +D +E R L + E+ +K + ++ Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE-----RRLEQAEEKHLKEKKNMQ 2142 Query: 1421 KQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKL 1480 ++L+ E V +I E+ +L K KE +L Sbjct: 2143 EKLDALRREKVHLEETI----GEIQVTLNK----------------------KDKEVQQL 2176 Query: 1481 RESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQ---------EVRCSG- 1530 +E+L L + +S++++ +R+ E + ER IQ E CS Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236 Query: 1531 ----QELSRVQEEVKLRQQLLSQNDKLLQS-----LRVELKAYEKLDEEHRRLRDGDKYP 1581 +++S EE+K+ L + ++ +S ++++ K + L E++ L Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS----- 2291 Query: 1582 MESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWA 1641 + + + L+ SSQ K SE L TD S + C Sbjct: 2292 -QLEETRHLYHSSQNELAKLESELKSLKDQLTDL-------SNSLEKC------------ 2331 Query: 1642 SKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQ-TQEAPSSTSQELGTKGPHPAPLSKF 1700 + ++ G+I EA ++ L E D+Q ++E S +E+ K K Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKE------QKI 2384 Query: 1701 VSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1760 +S +S + ++ A L+ + E Q E + + +KK ++ +L Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENL---LSQEEEENIVLEEENKKAVDKTNQL 2441 Query: 1761 QNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNL 1795 T+K ++ Q+K D V + L+ R + Sbjct: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476 Score = 111 bits (278), Expect = 6e-24 Identities = 330/1661 (19%), Positives = 652/1661 (39%), Gaps = 251/1661 (15%) Query: 84 LEERM--QQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAG-GS 140 LEE++ +++F + + +T + +++ L+ E+ E + ++ K + S +A G Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII---QKLITSNTDASDGD 1136 Query: 141 EIQRVKEDA------RKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGT--------E 186 + VKE + + L ++IL LEK+ Q +L++A E Sbjct: 1137 SVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE 1196 Query: 187 TEKALRL----------RLESKLSEMKKMHE--GDLAMALVLDEKDRLIEELKLSLKSK- 233 E+ LR RL+ + E K +E GD L + ++ + +L + + + Sbjct: 1197 KERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQES 1256 Query: 234 --------EALIQCLKEEKSQMA-----CPD---ENVSSGELRG---LCAAPREEKERET 274 E L + ++ +Q CPD + + L+G + + KE E Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316 Query: 275 EAAQMEHQKERNSFE-----ERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKS 329 E ++E + + E E + L+E + ++ EI + K S + + + L L+S Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376 Query: 330 KEKKV------EELNSEIEKLSAAFAKAREALQ--KAQTQEFQGS-EDYETALSGKEALS 380 + ++ EL ++++L +K E + Q E + + +T + +E L Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436 Query: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTI---R 437 AL +Q L + H R IK++ EL +++Q+ E + ++ + + K + + Sbjct: 1437 KALHTQ-LEMQAKEHDER--IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493 Query: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLS-ESNKKLHNQEQ--VIKHLTESTNQKDVLLQ 494 + E + L+ E++ +E KSL ES N+E+ V+ L ++D L+ Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI- 1552 Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554 E D +++ + E L+L EGL +K + +++ S + +S++++E Sbjct: 1553 --TEMDRSLLENQSLSSSCESLKLALEGLTEDK--EKLVKEIESLKSSKIAESTEWQEKH 1608 Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT------- 607 + L+KE +I LQ ++++N + + +Q +Q++ Y LR T Sbjct: 1609 KELQKEYEIL------LQSYENVSNEAERIQHVVEAVRQEKQEL--YGKLRSTEANKKET 1660 Query: 608 ---LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQ-------------- 650 L+E E+ +E+ + + EEN+R + E Sbjct: 1661 EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720 Query: 651 --------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPD-RLASTEQT 701 E +K + L + + L ++ L + + DL +GN L +TE+ Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ-IEGNVSKQANLEATEKH 1779 Query: 702 ELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNE-----------IMKDLSKGGCKNGYL 749 + + +E T I GE +E + LS +E + KD S N YL Sbjct: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYL 1839 Query: 750 RHTESKISDCDGAHAPGCLEEGAFIN--LLAPLFNEKATLL--LESRPDLLKVVRELLLG 805 + + G LEE N L NEK TLL + ++ LK+++E + Sbjct: 1840 QQIDQLKERIAG------LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893 Query: 806 QLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPK 865 L +Q K ++T +++ + + N ++ + + C+ Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ----------- 1942 Query: 866 VGLKDASVQTVATEGDLLRFKHEATREAWEEKPI----NTALSAEHRPENLHGVPGWQAA 921 + DA ++ E ++ K + E EEK T + +E R E L + G Q Sbjct: 1943 -DVTDAQIKNELLESEMKNLK-KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000 Query: 922 LLSLPGITNREAKKSRLPILIKPSRSLGNMYR--------LPATQEVVTQLQSQILELQG 973 PG N+ K +L + + + + + + A + V L+ E Q Sbjct: 2001 ----PG--NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054 Query: 974 ELKEFKTCNKQL--HQKLILAEAVMEGRPTPDKTLLN-AQPPVGAAYQDSPGEQKGIKTT 1030 +L+ K Q H+K AE K LL+ Q D+ +K +++ Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASF------KVLLDDTQSEAARVLADNLKLKKELQSN 2108 Query: 1031 SSVWRD--KEMDSDQQRSYE------IDSEICPPDDLASLPSCKENPEDVLSPTSVATYL 1082 + K+ D D +R E + + + L +L K + E+ + V Sbjct: 2109 KESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNK 2168 Query: 1083 SSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQ---C 1139 K + ++ T + T + + + ++ + + F +Q + Sbjct: 2169 KDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228 Query: 1140 SEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP--LAPEMIDSR 1197 E +VL +D L + + ++ S L + + K L ++ D+ Sbjct: 2229 KEDNCSVL------KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL 2282 Query: 1198 VLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSL 1255 EN L QLEE + QN +L SE+ +L+++ DLS +SL + + ++ +L Sbjct: 2283 QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLS----NSLEKCKEQKGNL 2338 Query: 1256 Q---RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE--------GFQEQLN- 1303 + RQQ D S + + T ++A EL + + E G +E + Sbjct: 2339 EGIIRQQEADIQN-SKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397 Query: 1304 QCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYE 1363 AEL ++ +K E+ L+ + EE+N+ + ++ + + + + Sbjct: 2398 AIAELRQQHDK----------EIKELENLLSQEEEENIVLEEENKKAVD-KTNQLMETLK 2446 Query: 1364 TSEKSFFSRDQKQDNETEKTSVMVNSFS------QDLLMEHIQEIRTLRKRLEESIKTNE 1417 T +K + + D+ + S + N Q L H+ I + ++E+ N Sbjct: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506 Query: 1418 KLRKQ---LERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQ 1474 KL+++ L + + + A + L I Q + L + ++ +++ + Sbjct: 2507 KLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE 2566 Query: 1475 KENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE-- 1532 + KL E L + E L+R + +++EE + L KE + QL ++V +E Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626 Query: 1533 -------LSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEK 1566 L +EEV L S + K + L EL +K Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQK 2667 Score = 110 bits (275), Expect = 1e-23 Identities = 361/1858 (19%), Positives = 731/1858 (39%), Gaps = 309/1858 (16%) Query: 106 LKVEVESLKRELQER-EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164 L ++E +E ER +QL ++ + + E G E R K+ ++K+Q L++++ Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG--EESRAKQQIQRKLQAA--LISRKE 1494 Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLA-MALVLDEKDRLI 223 L K+ + Q EL A E +ES++S K + L +AL+ +E+D+LI Sbjct: 1495 AL--KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552 Query: 224 EELKLSLKSKEAL----------IQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERE 273 E+ SL ++L ++ L E+K ++ E++ S ++ + KE + Sbjct: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612 Query: 274 TEAAQMEHQKERNSFE-ERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL- 327 E + E S E ERIQ + E +R++++E+ + + N + +K +Q + Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672 Query: 328 ----------KSKEKKVEELNSEIEKLSAAF------------------AKAREALQKAQ 359 KSK++K+ EL E ++L A A +E L++ + Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732 Query: 360 TQEFQGSEDYETALSGKEALSAALRSQ------NLTK-----STENHRLRRSI-KKITQE 407 + S+ +++ +S K++LS ++ N++K +TE H + ++ ++ TQ Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS 1792 Query: 408 LSDLQQERERLEKDL-----EEAHREKSKGDCTIRDLRN---------EVEKLRNEV--- 450 + +E++ L E KS +D + ++++L+ + Sbjct: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852 Query: 451 -------NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK---- 499 E + +EN +LLS+ + K + +K L E + ++L Q+ E+ Sbjct: 1853 EEEKQKNKEFSQTLENEKNTLLSQISTK----DGELKMLQEEVTKMNLLNQQIQEELSRV 1908 Query: 500 ------------DLEVIQQNC----------YLMAAEDLELRSEGLITE-----KCSSQQ 532 DLE N Y D ++++E L +E KC S+ Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968 Query: 533 PPGSKTIFSKEKKQSSD----YEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF 588 + + ++ K S+ Y E IQ +KE +H K LQE + Q E+ Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSH-AKELQEL--LKEKQQEV---- 2021 Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648 KQL++D + YQ LE + + + ES L+ +E + Q E Sbjct: 2022 ---KQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELA 2078 Query: 649 S--------QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700 S Q E + ++D ++L KEL ++ + +K S M + RL E+ Sbjct: 2079 SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK------SQMKQKDEDLERRLEQAEE 2132 Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQS-NEIMKDLSKGGCKNGYLRHTESKISDC 759 L K ++ + +++ HL+++ EI L+K K+ ++ + + Sbjct: 2133 KHLKEKKNMQEKLDALRREKV------HLEETIGEIQVTLNK---KDKEVQQLQENLDST 2183 Query: 760 DGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL 819 + AF ++ L +++ ++ E++ E++ S Sbjct: 2184 -------VTQLAAFTKSMSSLQDDRDRVIDEAKK----------------WERKFSDAIQ 2220 Query: 820 DGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSC-----EAQLVKAGEVPKVGLKDASVQ 874 + E K+ V Q S +ELK++ + Q+ ++ +V L+ Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280 Query: 875 TVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAK 934 T+ E L + E TR + N E ++L L ++N Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKD---------QLTDLSNS--- 2327 Query: 935 KSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILE-LQGELKEFKTCNKQLHQKLILAE 993 L K GN+ + QE Q E L+ +L+ + +LH+++ + E Sbjct: 2328 ------LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE 2381 Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053 + + + + Q + Q E K ++ S ++ + +++ +D Sbjct: 2382 QKIISLLSGKEEAI--QVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439 Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113 + L ++ KEN + K+Q + V M + Q++ + + L+ Sbjct: 2440 QLMETLKTIK--KEN-------------IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484 Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF-S 1172 ++ L LE Q ++++ E I G D L+ D E + + Sbjct: 2485 ER--HLSIILEKDQLIQEAAAENNKLKEEIR----GLRSHMDDLNSENAKLDAELIQYRE 2538 Query: 1173 SLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQN 1232 L+QV +K + L ++ ++ LEN +LEE KL++ + N L + LQ Sbjct: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE---KLKESEEANEDLRRSFNALQE 2595 Query: 1233 KFRDLSPPRYDSL---VQSQARELSLQRQQIKDG--HGICVISRQHMNTMIKAF----EE 1283 + +DLS +SL + R+++ +++ G H + + ++ + F + Sbjct: 2596 EKQDLSK-EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKR 2654 Query: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEK-LEKLFLNGKSVGVEMNTQNELMERIEEDNLT 1342 + + + CV + +++ + + L+K L+ L + + E T E + + D + Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714 Query: 1343 Y-QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLL-MEHIQ 1400 Q LL + E A ++ +S S +D+ E+ + + L + ++ Sbjct: 2715 MEQKLLMVTKENKGLTA--QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772 Query: 1401 EIRTLRKRL---------------EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445 E L + E S+ EKL +QL + + + S+ + S +++ Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ 2832 Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKT--VSLEHLQREYASVKE 1503 S + +++ N + + ++ E K R + T ++ L++ +S++ Sbjct: 2833 SFSKAMASLQNERDHLWNEL----EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQN 2888 Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE-----------EVKLRQQLLSQNDK 1552 + +RL KE ++ Q+ QE+ +++QE + +LRQ+ LS + Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHE 2948 Query: 1553 LLQSLRVELKAYEKLDEEHRRLRDGDKYPM---ESDNSFDLFDSSQAVTPKSVSETPPLS 1609 L Q LR+E ++E RR++ ++Y M + D + S S+T PL Sbjct: 2949 LHQ-LRMEKSSWE---IHERRMK--EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002 Query: 1610 GNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGL------IEDYEALLKQIS 1663 S ++ +S + LV L ++ + + I+ + Q+ Sbjct: 3003 VQYQRQASPETSASPDGS---QNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLL 3059 Query: 1664 QGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLE---EAYRRLKL 1720 + + L+ T ++ Q G H A L K V + L ++ A + Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119 Query: 1721 LWRVSLPEDGQCPLHC-----EQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQ 1773 + R S PE+ + P +Q+ + EV +L K L E+ + L +++ Q Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177 Score = 94.4 bits (233), Expect = 9e-19 Identities = 366/1895 (19%), Positives = 711/1895 (37%), Gaps = 284/1895 (14%) Query: 101 KTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL 160 K++ E ++E+E +K +LQE+E+L+ S L +A + + + + V + L Sbjct: 137 KSSTEEEMEIEKIKHKLQEKEELI---STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ 193 Query: 161 TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH-----EGDLAMALV 215 K + +Q + E+A EK R + +L E + + + + M Sbjct: 194 EKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQK 253 Query: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSS---------GELRGLCAAP 266 L R +EE + SL + ++ L++E + ++ +S LR Sbjct: 254 LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313 Query: 267 REEKERETEAAQMEHQKERNSF----EERIQALEEDLREKEREIATEKKNSL---KRDKA 319 REE + E ++E + + SF EE LE+ + + + E + S K Sbjct: 314 REESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373 Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAKA-----REALQKAQT------QEFQGSED 368 ++ T + S +K +EL S + L +K +A+Q AQT Q Q S++ Sbjct: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE 433 Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLR----RSIKKITQELSDLQQERERL---EKD 421 L+ SQ N + +I + + + +L+ E+ L + Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493 Query: 422 LEE--AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479 LEE A EK T+ + +N + EV+E S++ +NK+ + E+ Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSE---------ISIVDIANKRSSSAEESG 544 Query: 480 KHLTEST-----NQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPP 534 + + E+T + VLL + E E+ L E E L ++ + Sbjct: 545 QDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604 Query: 535 G----SKTIFSKEKKQS----SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNK 586 G +F ++ Q + E + ++KEQ H ++ +E S+N+ EL Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI-SLNDAGVELKS 663 Query: 587 IFALRKQLEQDVLS--------YQNLRKTLEEQISEIRRREEESFSLY-------SDQTS 631 KQ LS +Q+ + L+ QI E+ ++ +Y + + S Sbjct: 664 ----TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEIS 719 Query: 632 YLSICLEE------NNRFQVEHFSQE--ELKKKVSDLIQLVKELYTDNQHLKKTIFDLS- 682 L+ +EE NN S+E +L +V +L +V EL + L+ + + Sbjct: 720 NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL-SMVTELRAQVKQLEMNLAEAER 778 Query: 683 --CMGFQGNGFPDRLASTEQTELLASKEDEDTIKIG------EDDEINFLSDQHLQQSNE 734 + ++ D L TEQ L+ + +KI +D ++ F L +S + Sbjct: 779 QRRLDYESQTAHDNLL-TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ 837 Query: 735 IMKDLSKGGCKNG--YLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL---LL 789 + G +RH SK+ + A + LE LL + TL + Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE 897 Query: 790 ESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDEL 849 E + ++ + + L E++ S G KT K++ L+ + + ++ Sbjct: 898 EKDQQVTEISFSMTEKMVQLNEEKFS----LGVEIKTLKEQLNLLSRAEEAKKEQVEEDN 953 Query: 850 KLSCEA-----QLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALS 904 ++S ++ AG++ K L+ E DLL+ ++E + + IN Sbjct: 954 EVSSGLKQNYDEMSPAGQISKEELQH--------EFDLLKKENEQRKRKLQAALIN---- 1001 Query: 905 AEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPIL---------IKPSRSLGNMYRLP 955 R E L V + L +L ++ K +P+ K ++ Sbjct: 1002 ---RKELLQRVSRLEEELANL-----KDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053 Query: 956 ATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGA 1015 QE+ L+ I E + EL+ + K L +KL E ++TL + + Sbjct: 1054 KCQEIEIYLKQTISEKEVELQHIR---KDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110 Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSP 1075 + Q I+ + D D D + I PP +S E E +L+ Sbjct: 1111 LQAEISENQAIIQKLITSNTDAS-DGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169 Query: 1076 TSVATYLSSKSQP--SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY----QNF 1129 L K Q +++ +++ Q + + E + K + L+ + + +N Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229 Query: 1130 IFQL-QKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188 QL Q Q E+I L T+ + S P G + + H + V + Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--GLEEPLFKATEQHHTQPVLESNLCPD 1287 Query: 1189 LAPEMIDSRVLE------NLKQQLEEQE--------------YKLQKEQNLNMQLFSEIH 1228 D+ L+ +K QL+E E +L K+ QL +I+ Sbjct: 1288 WPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347 Query: 1229 NLQNKFRDLSPPRYDSLVQSQARELSLQRQQI-----------------------KDGHG 1265 + L +++ V +++ + L+ Q+ K Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407 Query: 1266 ICVISRQHMN---TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE----KLFLN 1318 + +S Q + K E+++ D+ + + Q + E +++L+ ++ Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467 Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPE--SPEPSASHALSDYETSEKSFFSRD--- 1373 + +G E + ++ +++ ++ + L E S + S A E KS + Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527 Query: 1374 --QKQDNET---------EKTSVMVNSFSQDLLMEH--IQEIRTLRKRLEESIKTNEKLR 1420 Q ++ +T E+ ++ + LL +L+ LE + EKL Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587 Query: 1421 KQLERQGSEFVQGSTSIFASGSEL----------HSSLTSE-------IHFLRKQNQALN 1463 K++E S + ST EL + ++++E + +R++ Q L Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647 Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVK--------EENERLQKE---- 1511 L + + +KE +K + ++ ++ R++A K EEN+RL+ E Sbjct: 1648 GKL-RSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706 Query: 1512 GSEKERHNQQLIQEVRCSGQELSRVQEEV----KLRQQLLSQNDKLLQSLRVELKAYEKL 1567 G + + L+ +EL RV+ E K Q L+S+ D L + ++ E Sbjct: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGN 1766 Query: 1568 DEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATST 1627 + L +K+ DN ++ + P E LS + + S S+ ++ Sbjct: 1767 VSKQANLEATEKH----DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822 Query: 1628 PCVSRLVTGH-----HLWASKNGRHVLGLIEDYEALLKQISQ---GQRLLAEMDIQTQEA 1679 P VS+ + H +L + + +E+ + K+ SQ ++ I T++ Sbjct: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDG 1882 Query: 1680 PSSTSQELGTK-GPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPE-DGQCPLHCE 1737 QE TK + + +S V+ K T EE L+ L E +G +C+ Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942 Query: 1738 QIGE-------MKAEVTKLHKKLFEQEKKLQNTMK 1765 + + +++E+ L K + E E++ Q +K Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK 1977 Score = 92.0 bits (227), Expect = 5e-18 Identities = 336/1761 (19%), Positives = 669/1761 (37%), Gaps = 286/1761 (16%) Query: 16 LSGCSGLVPSVPDDLDGINP-NAGLGNGLLPNVSEETVSPTRARNMKDFENQ-------I 67 LS SGL V +L G + + + L P + +E+ +D + + + Sbjct: 2 LSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLV 61 Query: 68 TELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE----QL 123 ELK +++ +E +Q+E I K + K ++ SL + ++E + + Sbjct: 62 VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV 121 Query: 124 LIKASKAVESLA--EAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKA 181 L ++ E L+ + +E + E + K+Q+ E+L++ L+ +T AQAE + A Sbjct: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELIS----TLQAQLTQAQAE-QPA 176 Query: 182 FAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK 241 + TE E+ + ++ + L EK+ I L+ L +A Sbjct: 177 QSSTEMEEFVMMKQQ-------------------LQEKEEFISTLQAQLSQTQA------ 211 Query: 242 EEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLRE 301 E+ +Q +++ + + E E Q+ Q + + +++ LR Sbjct: 212 EQAAQQVVREKD---------ARFETQVRLHEDELLQLVTQADVET------EMQQKLRV 256 Query: 302 KEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 +R++ +++ + R + + L L + E++ + L+ +++++ A R ++ + + Sbjct: 257 LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE 316 Query: 362 EFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKD 421 E E E L NL + E H L ++ Q ++L+ LE+ Sbjct: 317 SKILLEKMEL-----EVAERKLSFHNLQE--EMHHLLEQFEQAGQAQAELESRYSALEQK 369 Query: 422 LEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKH 481 + EK+ ++ +K E+ A++++ LL + N++ Q I+ Sbjct: 370 HKAEMEEKTSHILSL-------QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422 Query: 482 LTESTNQKDVLLQKF-NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540 L + QK + +F N L+ + + ++ + E +S Q K + Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ----KRVV 478 Query: 541 SKEKKQSSDYEELIQV--LKKEQDIYTHLVKSLQESDSINNLQAEL---------NKIFA 589 E ++ + I++ LK E + + + L+ + E+ NK + Sbjct: 479 ELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538 Query: 590 LRKQLEQDVL--SYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEH 647 ++ QDVL ++ K L + E++ +EE ++L + L+ + +H Sbjct: 539 SAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE--------IAFLKLQLQGKRAEEADH 590 Query: 648 --FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP---DRLASTEQ-- 700 Q+E+K+ + I +K L+ T D M + + P ASTE Sbjct: 591 EVLDQKEMKQMEGEGIAPIKM----KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS 646 Query: 701 ------------TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMK-DLSKGGCKNG 747 EL ++K+D D D D+ + ++I++ +L+ + Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706 Query: 748 YLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKA-------TLLLESRPDLLKVVR 800 Y ++ + K + +N L F + A T L E R LL V+ Sbjct: 707 YEKNLDEKAKEISN------------LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754 Query: 801 ELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQT---NSFSKPHDELKLSCEAQL 857 EL + +TE + L+ + +Q+ L + QT N ++ L + +++ Sbjct: 755 ELSM----VTELRAQVKQLEMNLAEAERQR-RLDYESQTAHDNLLTEQIHSLSIEAKSKD 809 Query: 858 VKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPG 917 VK EV + L D +Q + + L+R ++ + E + + A H + + Sbjct: 810 VKI-EVLQNELDDVQLQ-FSEQSTLIR-SLQSQLQNKESEVLEGAERVRHISSKVEELS- 865 Query: 918 WQAALLSLPGITNREAKKSRL-PILIKPSRSLGNMYR-LPATQEVVTQLQSQILELQGEL 975 ++ +E + +++ +L++ R + + + + + VT++ + E +L Sbjct: 866 --------QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917 Query: 976 KEFKTC----NKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTS 1031 E K K L ++L L E + K + V + + + E S Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAK----KEQVEEDNEVSSGLKQNYDEMSPAGQIS 973 Query: 1032 SVWRDKEMD----SDQQRSYEIDSEICPPDDLASLPS-CKENPEDVLSPTSVATYLSSKS 1086 E D ++QR ++ + + +L S +E ++ + LS Sbjct: 974 KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033 Query: 1087 QPSAKVSVMGTDQSESINTSNETE---YLKQKIHDLETEL--------------EGYQNF 1129 + + + SE TS E YLKQ I + E EL E +Q Sbjct: 1034 RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093 Query: 1130 IFQLQKHSQCSEAIITVLCGTEG-----AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVK 1184 + Q+ + Q I +L Q ++ + SDG+ V VK Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD--------SVALVKETV 1145 Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244 ++ P + E+ K +LEE+ L+KE+ LQ K ++ R Sbjct: 1146 VISPPC-----TGSSEHWKPELEEKILALEKEK----------EQLQKKLQEALTSRKAI 1190 Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304 L ++Q +E L R+++K + N + + F+E + + E +QL Q Sbjct: 1191 LKKAQEKERHL-REELKQ-------QKDDYNRLQEQFDEQSKEN-------ENIGDQLRQ 1235 Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEED--NLTYQH---------LLPESPEP 1353 L+ + ++GK + +EE T QH L P+ P Sbjct: 1236 ----LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH 1291 Query: 1354 SASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI 1413 S + TS ++ ++ + E + + V+S + + L K+ EE Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE-----------LTKKSEEVF 1340 Query: 1414 KTNEKLRKQ-LERQGSEFVQGSTSIFA-------SGSELHSSLTSEIHFLRKQNQALNAM 1465 + E++ KQ LE + + V + A S+L + + L+ + L + Sbjct: 1341 QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKL 1400 Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS----VKEENERLQKEGSEKERHNQQ 1521 + K K+++ L LS K +L +Q E +K + +L+ + E + +Q Sbjct: 1401 ISK----KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ 1456 Query: 1522 LIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYP 1581 L E+ Q+ + EE + +QQ+ + L S + LK + L EE R + Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516 Query: 1582 MESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWA 1641 +S + S+Q +V L + D L + S +S L Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL-- 1574 Query: 1642 SKNGRHVLGLIEDYEALLKQI 1662 + GL ED E L+K+I Sbjct: 1575 -----ALEGLTEDKEKLVKEI 1590 Score = 78.2 bits (191), Expect = 7e-14 Identities = 138/682 (20%), Positives = 270/682 (39%), Gaps = 114/682 (16%) Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117 + +K+ EN +++ ++EN L+ ++ Q + I K NI+ K +++S + + Sbjct: 2408 KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME-TLKTIKKENIQQKAQLDSFVKSM 2466 Query: 118 --------------QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163 Q+ E+ + + L + +E ++KE+ R ++DL ++ Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526 Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRL---------------RLESKLSEMKKMHEG 208 L + ++ + +L + ++++ L +LE KL E ++ +E Sbjct: 2527 AKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE- 2584 Query: 209 DLAMAL--VLDEKDRL---IEELKLSLKSKEALIQCLKEE------KSQMACPDENV--- 254 DL + + +EK L IE LK+S+ + L+EE +Q+ +E V Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644 Query: 255 ----SSGELR------GLCAAPRE--------EKERETEAAQMEH-----QKERNSFEER 291 SS + R L +E E + + E + H + E + EER Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704 Query: 292 IQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKA 351 + L DL E E+++ K + IQ ++ S + + N E+++L + + Sbjct: 2705 VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764 Query: 352 REALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDL 411 + L + + Q E AL + A S STE + L ++K+ Q+L Sbjct: 2765 LKELAQLKEQGLLNRE--RDALLSETAFSM--------NSTEENSLSH-LEKLNQQLLSK 2813 Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKK 471 ++ L LE+++ + + L+NE + L NE+ + K+ E + +S S Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2873 Query: 472 LHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL--------------- 516 Q + K ++ N +D LL++ + +Q N + L Sbjct: 2874 AEVQ-SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQ 2932 Query: 517 ----ELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI--YTHLVKS 570 ELR E L + Q + E++ Y L+ + K+Q + +L++ Sbjct: 2933 IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY--LMAISDKDQQLSHLQNLIRE 2990 Query: 571 LQESDS-INNLQAELNKIFALRKQLEQD-----VLSYQNLRKTLEEQISEIRRREEESFS 624 L+ S S L+ + + + D V + LR L + + EI ++E Sbjct: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ 3050 Query: 625 LYSDQTSYLSICLEENNRFQVE 646 L S+ S LEE N ++ Sbjct: 3051 LNSN----FSQLLEEKNTLSIQ 3068 Score = 72.8 bits (177), Expect = 3e-12 Identities = 133/669 (19%), Positives = 279/669 (41%), Gaps = 141/669 (21%) Query: 64 ENQITELK-KENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQ 122 + Q+ E++ ++N L+ + LEE+++ E E + ++ L+ E + L +E++ + Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEKLK-ESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609 Query: 123 LLIKASKAVESLAEAGGSEIQ----RVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAEL 178 + + ++ V +L E G + +VKE+ ++ + KRI LE+++ Q E Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669 Query: 179 EKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLIEELKLSL-KSKEAL 236 K +E KL E+K +H M + + + EL L + ++ L Sbjct: 2670 AKKVG----------EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719 Query: 237 IQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALE 296 + KE K A + S G R+ E + + ++ S +E Q E Sbjct: 2720 LMVTKENKGLTA---QIQSFGRSMSSLQNSRDHANEELDELKRKYDA---SLKELAQLKE 2773 Query: 297 EDLREKERE---------IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE---KL 344 + L +ER+ + + ++NSL ++ L L SK++++ L+S++E Sbjct: 2774 QGLLNRERDALLSETAFSMNSTEENSLSH---LEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830 Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRS-----QNLTKSTENHRLRR 399 +F+KA +LQ + + E + + GK+ +A + Q+L K+ + L+ Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS--LQN 2888 Query: 400 SIKKITQELSDLQQERERLEKDLEEAH---------REKSKGDCTIRD--------LRNE 442 ++ +EL +LQQ+ ++ +++ E H ++K+K +++ ++E Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHE 2948 Query: 443 VEKLRNEVNE---REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499 + +LR E + E+ M+ +Y +S+ +++L + + +I+ L S++Q L ++ Sbjct: 2949 LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR- 3007 Query: 500 DLEVIQQNCYLMAAEDLELRSEGLI--TEKCSSQQPPGSKTIFSKE---KKQSSDYEELI 554 Q + A+ D S+ L+ TE +Q K I KE ++ +S++ +L+ Sbjct: 3008 -----QASPETSASPD---GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLL 3059 Query: 555 --------------QVLKKEQDIYTHLV-------KSLQE-------------------- 573 Q L++ Q Y L+ K +QE Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119 Query: 574 --------------------SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQIS 613 + N + E+N++ L ++ ++ +N EEQI Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179 Query: 614 EIRRREEES 622 + E +S Sbjct: 3180 RLEHSEWDS 3188 Score = 55.8 bits (133), Expect = 4e-07 Identities = 115/508 (22%), Positives = 206/508 (40%), Gaps = 102/508 (20%) Query: 48 SEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK 107 +EE V+ AR++ + E ++ + KEN L +I M +H + ELK Sbjct: 2701 AEERVAEL-ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS-LQNSRDHANEELDELK 2758 Query: 108 VEVESLKREL----------QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVE 157 + ++ +EL +ER+ LL + + ++ S E S ++++ + K +Q+ Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818 Query: 158 DLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLD 217 L ++ LE Q+ KA A + E R L ++L + +K EG A Sbjct: 2819 HLSSQ----LEDSYNQVQS-FSKAMASLQNE---RDHLWNELEKFRKSEEGKQRSAAQPS 2870 Query: 218 EKDRLIEELKLSLKS----KEALIQCLKEEKSQMACPDENVSSGELRGLCAAPRE--EKE 271 ++ LK ++ S ++ L++ LK + Q ++ ++ EL L A +E +K Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT--ELHPLKAQLQEYQDKT 2928 Query: 272 RETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKE 331 + + Q E ++E S++ + L + E K+ L MA+ K+ Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL----------MAISDKD 2978 Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQ---EFQGSED------YETAL-------SG 375 +++ L + I +L ++ ++ + + Q Q E S D YET L S Sbjct: 2979 QQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSL 3038 Query: 376 KEALSAALRSQNLT---------KSTENHRL---RRSIKKITQELSDLQQERERLEKDLE 423 KE LR Q L K+T + +L +S+++ Q DL LEK ++ Sbjct: 3039 KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQ 3098 Query: 424 E-------------AHREKS----KGD------------------CTIRDLRNEVEKLRN 448 E A +EK+ K D C R NE+ KL Sbjct: 3099 ELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLE 3158 Query: 449 EVNEREKAMENRYKSLLSESNKKLHNQE 476 E ++ A EN S+ E ++L + E Sbjct: 3159 EERDQRVAAENAL-SVAEEQIRRLEHSE 3185 Score = 47.0 bits (110), Expect = 2e-04 Identities = 147/781 (18%), Positives = 293/781 (37%), Gaps = 130/781 (16%) Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAII------------TVLCGTEGAQDGLSK 1159 L+QK L+ E + N I +L+ H++ + TVL +++ LSK Sbjct: 75 LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134 Query: 1160 PKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNL 1219 S EEM + K +++ L ++ ++ + + E +E+ + K+Q Sbjct: 135 HDKSSTEEEMEIEKIKHKLQEKE-ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ 193 Query: 1220 NMQLFSEIHNLQNKFRDLSPPRY--------DSLVQSQARELSLQRQQIKDGHGICVISR 1271 + F I LQ + + D+ ++Q R + Q+ + + Sbjct: 194 EKEEF--ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ 251 Query: 1272 QHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAE----LLEKLEKLFLNGKSVGVEMN 1327 Q + + + EE ++ V + Q++L + L ++L+++ ++ + Sbjct: 252 QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311 Query: 1328 TQNE----LMERIE----EDNLTYQHLLPESPEPSASHALSDYETS-------EKSFFSR 1372 T+ E L+E++E E L++ +L E H L +E + E + + Sbjct: 312 TEREESKILLEKMELEVAERKLSFHNLQEEM-----HHLLEQFEQAGQAQAELESRYSAL 366 Query: 1373 DQKQDNETE----------KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQ 1422 +QK E E KT + S L ++ + ++ ++ +S +T ++L Q Sbjct: 367 EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426 Query: 1423 LERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRE 1482 L+++ E Q + E +S TS + QA+ I + + E + + Sbjct: 427 LQQKSKEISQFLNRLPLQQHET-ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKG 485 Query: 1483 SLSRKTVSLEHLQREYASVKEENERLQ----------------------KEGSEKERHNQ 1520 +L ++ LE L+ E + + L+ K S E Q Sbjct: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545 Query: 1521 QLIQEVRCSG-QELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGD- 1578 +++ +ELS + E+K Q+ ++ LQ R E +E LD++ + +G+ Sbjct: 546 DVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEG 605 Query: 1579 ---------------KYPM--ESDNSFDLFDSSQAVTPKSVSETPPLSGNDT----DSLS 1617 +P+ ++S + QA T + +S ND S Sbjct: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665 Query: 1618 CDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGL-------IEDYEALL----KQISQGQ 1666 D S ++ P + + H + +L L E YE L K+IS Sbjct: 666 QDGDKSLSAVPDIGQC---HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN 722 Query: 1667 RLLAEMDIQTQE------APSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL 1720 +L+ E A S +L ++ + +++ + V ++ L EA R+ +L Sbjct: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRL 782 Query: 1721 LWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQ 1780 + D L EQI + E K+ + LQN + +QL ++ + Sbjct: 783 DYESQTAHDN---LLTEQIHSLSIEAKSKDVKI----EVLQNELDDVQLQFSEQSTLIRS 835 Query: 1781 L 1781 L Sbjct: 836 L 836 >gi|55770834 centromere protein F [Homo sapiens] Length = 3114 Score = 111 bits (277), Expect = 7e-24 Identities = 336/1579 (21%), Positives = 635/1579 (40%), Gaps = 252/1579 (15%) Query: 101 KTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL 160 K + L+ V+SL+ L+ ++Q+ K E L + G EI+ A + Q Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG-EIEENLMKAEQMHQSFVAET 881 Query: 161 TKRILLLEKDVTAAQAELEKAFAGTET-EKALRL---RLESKLSEMKKMHEGDLAMALVL 216 ++RI L++D +A Q + + + E EK L+L ++E++ +E++++ + + + L Sbjct: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941 Query: 217 DEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276 E L E L L K ++I K E ++ EN G L+ + A+ +EK Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELT--QEN---GTLKEINASLNQEK------ 990 Query: 277 AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE 336 M ++ SF I E+ + E + EK L+R + L K K +E Sbjct: 991 --MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE 1048 Query: 337 LNS------------------EIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEA 378 NS E+E+L AFAK Q+ T+ E + + E Sbjct: 1049 KNSKLECLLNECTSLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELET 1105 Query: 379 LSAALRS-----QNLTKST------ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHR 427 + ALRS QN +KS E L+ K+ +E++DL QE E+L K ++ H Sbjct: 1106 VQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165 Query: 428 EKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL-LSESNKKLHNQEQVIKHLTEST 486 ++ IR+ E E RN+ N + + M+ K + L N +L E ++++ Sbjct: 1166 CQNLESEPIRNSVKERESERNQCNFKPQ-MDLEVKEISLDSYNAQLVQLEAMLRN----- 1219 Query: 487 NQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSK--TIFSKEK 544 K++ LQ+ +EK+ E +Q + DLE + + SQ+ G K I ++EK Sbjct: 1220 --KELKLQE-SEKEKECLQHELQTIRG-DLETSN----LQDMQSQEISGLKDCEIDAEEK 1271 Query: 545 KQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQN- 603 S +E L Q+ HL SLQ ++N L EL KI + + + ++++ N Sbjct: 1272 YISGPHE-----LSTSQNDNAHLQCSLQ--TTMNKLN-ELEKICEILQAEKYELVTELND 1323 Query: 604 --------LRKTLEE---QISEIRRREEESFSLY----------------SDQTSYLSIC 636 RK EE ++E++ ++S L+ ++Q Sbjct: 1324 SRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAP 1383 Query: 637 LEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLA 696 L+E+N ++ S +E++ ++L +E + Q K + D C Sbjct: 1384 LDESNSYEHLTLSDKEVQMHFAEL----QEKFLSLQSEHKILHDQHCQ-----------M 1428 Query: 697 STEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKI 756 S++ +EL + D++K E LS +++K++ G + G + S Sbjct: 1429 SSKMSEL---QTYVDSLKA----ENLVLSTNLRNFQGDLVKEMQL-GLEEGLVPSLSS-- 1478 Query: 757 SDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSG 816 S + + L + +F L + + L S + + + ++F + + Sbjct: 1479 SCVPDSSSLSSLGDSSFYR---ALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS--SLQE 1533 Query: 817 EHLDGKTEKTPKQKG--ELVHFVQTNSFSKPHDELKLSCEAQ-LVKAGEVPKVGLKDASV 873 E+L K + KG EL + + + ++L+ E+Q ++K E+ ++ + + Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEV--YRQSLEKLEEKMESQGIMKNKEIQEL---EQLL 1588 Query: 874 QTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREA 933 + E D LR ++ + E W++K + L E + Q LSL E Sbjct: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESK----LAAEKKQTEQLSL----ELEV 1640 Query: 934 KKSRLPILIKPSRSLGNMYRLPATQ------EVVTQLQSQILELQGELKEFKTCNKQLHQ 987 + +L L SRSL + A Q ++ + S+ E + + C+K Q Sbjct: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQ 1700 Query: 988 KLIL-AEAVME-GRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQR 1045 L L E + E G P Q P + PGE K ++ + + Sbjct: 1701 DLNLDIEKITETGAVKPTGECSGEQSP--DTNYEPPGEDKTQGSSECI---------SEL 1749 Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINT 1105 S+ + + P D L N ED+ ++ + S + ++ + D+ + + Sbjct: 1750 SFSGPNALVPMDFLG-------NQEDI---HNLQLRVKETSNENLRLLHVIEDRDRKVES 1799 Query: 1106 -SNETEYLKQKIHDLETELEGYQNFIFQLQK--------HSQCSEAIITVLCG------- 1149 NE + L K+H E +L +L+K +S SE + C Sbjct: 1800 LLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQR 1859 Query: 1150 ---TEGAQDGLSKPKNGSDGEEM-----TFSSLHQVRYVKHVKILGPLAPEM-------- 1193 +EG L + S E++ + + R++ L + E Sbjct: 1860 VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919 Query: 1194 ---IDSRVLENLKQQLEEQEYKLQK-----EQNLNMQLFSEIHNLQNKFRDLSPPRYDSL 1245 D V++ K LE+ QK E+ L++ + SE + L+ + +S + + Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV-VTSERNQLRGELDTMS--KKTTA 1976 Query: 1246 VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305 + + ++ + Q+++ C+ Q +K ELLQ D E L Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD------VSELLKDK 2030 Query: 1306 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS 1365 L EKL+ L + +++ + T+ EL +I + N + L+ ES A + SDYE Sbjct: 2031 THLQEKLQSLEKDSQALSL---TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087 Query: 1366 EKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRLEESIKTNEKLRKQL 1423 S E V F+ L E + ++R ++L I+ +EK + + Sbjct: 2088 NVS---------KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHI 2138 Query: 1424 ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRES 1483 + E + + S+ L L + ++NQ L +I + + + E + L+ Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQ-----MSEENQEL---VILDAENSKAEVETLKTQ 2190 Query: 1484 LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLR 1543 + SL+ + + +++ E E L K+ EK+ +L ++ S + L +E+ ++ Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-DKLLSSFKSLLEEKEQAEI- 2248 Query: 1544 QQLLSQNDKLLQSLRVELK 1562 Q+ ++ ++ L+ +LK Sbjct: 2249 -QIKEESKTAVEMLQNQLK 2266 Score = 88.2 bits (217), Expect = 7e-17 Identities = 162/743 (21%), Positives = 311/743 (41%), Gaps = 84/743 (11%) Query: 57 ARNMKDFENQITELKKENFNLKLRIYFLEERMQ-----QEFHGPTEHIYKTNIE------ 105 A +K+ E + LK + NL+ + EE + E KT IE Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198 Query: 106 ---------LKVEVESLKRELQEREQLLIKASKAVES----LAEAGGSEIQRVKEDARKK 152 L+ E E+L +++QE++ L + K + S L E +EIQ +KE+++ Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ-IKEESKTA 2257 Query: 153 VQQVEDLL---TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGD 209 V+ +++ L + + L D +A + E E LR +E + ++ + Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317 Query: 210 LAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGE----------- 258 L + L E + + LK +++ E ++ + + A EN S GE Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-SKGEVETLKAKIEGM 2376 Query: 259 ---LRGL---CAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKN 312 LRGL R EKE T Q E Q+ + E + E L+EKE+E K+ Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKE-QERISELEIINSSFENILQEKEQEKVQMKEK 2435 Query: 313 SLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETA 372 S A++ L LK ++V L+++ E A ++ + ++ Q + + A Sbjct: 2436 S---STAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492 Query: 373 LSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK--DLEEAHREKS 430 + L +++ +L + ++I++ + +Q + + + K +E H+ Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552 Query: 431 KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490 + + +R+L E+E+ + + ++++ + +L S K L N+ ++ K S +K Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLE-VLQSSYKNLENELELTKMDKMSFVEK- 2610 Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550 + K K+ E +Q+ + MA + EL+ E L EK + G + +E K S D Sbjct: 2611 --VNKMTAKETE-LQREMHEMAQKTAELQEE-LSGEK---NRLAGELQLLLEEIKSSKDQ 2663 Query: 551 EELIQVLKKEQDIYTHLVKSLQ--ESDSINNLQAELNKIFALRKQLEQDVLSYQNL---- 604 + + + E L KSL D + +I + +L + +Q L Sbjct: 2664 LKELTLENSE------LKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717 Query: 605 RKTLEEQISEIRRR---EEESFSLYSDQTSYLSICLEE-NNRFQVEHFSQEELKKKVSDL 660 K E +I R + +EE S + L EE NN + EELKK D Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777 Query: 661 IQLVKELYTDNQHL--KKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGED 718 ++ V +L +N+ K + SC + + E ++L A++E + T + D Sbjct: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEE---KEILQKELSQLQAAQEKQKTGTV-MD 2833 Query: 719 DEINFLSDQHLQQSNEIMKDLSK 741 +++ L+ + +++ E +++ +K Sbjct: 2834 TKVDELTTE-IKELKETLEEKTK 2855 Score = 85.1 bits (209), Expect = 6e-16 Identities = 294/1521 (19%), Positives = 587/1521 (38%), Gaps = 221/1521 (14%) Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240 ++A E ++ L R K+ E+ EG L D+ + ++ + L S EA +Q Sbjct: 2 SWALEEWKEGLPTRALQKIQEL----EGQL------DKLKKEKQQRQFQLDSLEAALQKQ 51 Query: 241 KEEKSQMACPDENVS--SGELRGLCAAPREEKERETEAAQMEHQK------ERNSFEERI 292 K++ N+ + L +C + + K++ + Q++ + + NS +++I Sbjct: 52 KQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI 111 Query: 293 QALEEDLREKEREIATEKKNSLKRDKAIQG-----------LTMALKSKEKKVEEL---- 337 + LE++L+ + E+ ++ + D ++ LT + K E+L Sbjct: 112 EKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY 171 Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ------NLTKS 391 N E+E+ A+ + K +Q + ++ +A S+ Q +L+ + Sbjct: 172 NKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231 Query: 392 TENHRLRRSIKKI----TQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447 ++ +RR QE++ + + ++D + + S + L+ + ++LR Sbjct: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291 Query: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507 N++NE E ++ K + + NK Q Q+ K E ++ VL + +E Q + Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351 Query: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIY--- 564 LE + + L TE S Q+ S E+K +E + L ++Q + Sbjct: 352 QASTKYTALEQKLKKL-TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTL 410 Query: 565 --------THLVKSLQESDSINN-LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI--- 612 L + LQ++ +++N LQAEL+K+ ++++QLE ++ ++ E+ Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470 Query: 613 ----SEIRRREEES------FSLYSDQTSY-----------LSICLEENNRFQVE----H 647 +E+RR EE +S+Q + + CL ++ F E + Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530 Query: 648 FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCM-GFQGNGFPDRLASTEQTELLAS 706 SQE + + + + I + T + LK + DL + R EQ S Sbjct: 531 TSQETMLRDLQEKINQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589 Query: 707 KEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPG 766 K ++++ + E+ + L++ + K +E + H Sbjct: 590 KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649 Query: 767 CLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKT 826 CL+ + + +NE+ L R +L +R L LD K+ + Sbjct: 650 CLKTQ---QIKSHEYNERVRTLEMDRENLSVEIRNL-------------HNVLDSKSVEV 693 Query: 827 PKQKGELVHFVQTNSFS--KPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDL-- 882 QK + Q FS K E++ C G+V + K + + D Sbjct: 694 ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCY 753 Query: 883 --LRFKHEATREAWEEKPINTALSAEHR---------PENLHG---VPGWQAALLSLPGI 928 L ++E+ R+ + K + + +H+ P H + G Q ++ S Sbjct: 754 QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSE 813 Query: 929 TNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQ---ILELQGELKEFKTCNKQL 985 EA +S I +R + L + +++ + LQ Q +++++GE++E +Q+ Sbjct: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873 Query: 986 HQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQR 1045 HQ + + +D+ Q + T S +KE + Q Sbjct: 874 HQSFV----------------AETSQRISKLQEDTSAHQNVVAETLSALENKEKEL-QLL 916 Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTS-VATYLSSKSQPSAKVSVMGTDQSESIN 1104 + ++++E ++ L ED L ++ LS + + + + + + E + Sbjct: 917 NDKVETE---QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 973 Query: 1105 TSNET-----EYLKQKIHDLETELEGYQNFIFQLQKH-SQCSE------AIITVLCGTEG 1152 N T L Q+ +L + E + N+I + +K S+ S+ I+ C G Sbjct: 974 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1033 Query: 1153 -AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR--VLENLKQQL--E 1207 A + LS+ + + L + ++R LE LK+ E Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNE------------CTSLCENRKNELEQLKEAFAKE 1081 Query: 1208 EQEY--KLQKEQNLNMQLFSEIHNLQNKFR-------DLSPPRYDSLVQSQARELSLQRQ 1258 QE+ KL + N L E+ +Q R + S L Q Q + Sbjct: 1082 HQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141 Query: 1259 QIKDGHGICVISRQHMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQC---AELLEKLEK 1314 K+ + + + Q M M E + L++ + V E E+ NQC ++ ++++ Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER-NQCNFKPQMDLEVKE 1200 Query: 1315 LFL---NGKSVGVEMNTQNE--LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF 1369 + L N + V +E +N+ ++ E++ QH L + L D ++ E S Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260 Query: 1370 FSRDQKQDNETE--------KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421 +D + D E + TS N+ Q L + ++ L K E +L Sbjct: 1261 L-KDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319 Query: 1422 QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK---GSRDKQKEND 1478 +L SE + + + +E L +E+ L + L+ L++ G ++ N+ Sbjct: 1320 ELNDSRSECITATRKM----AEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE 1375 Query: 1479 KLRESLS---------RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529 + SL+ T+S + +Q +A ++E+ LQ E K H+Q + S Sbjct: 1376 QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE--HKILHDQHCQMSSKMS 1433 Query: 1530 GQELSRVQEEVKLRQQLLSQN 1550 EL + +K +LS N Sbjct: 1434 --ELQTYVDSLKAENLVLSTN 1452 Score = 84.3 bits (207), Expect = 1e-15 Identities = 239/1205 (19%), Positives = 472/1205 (39%), Gaps = 191/1205 (15%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ- 118 ++D + ++ L E L +++ E ++ + E + K ELK E L +L+ Sbjct: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIE-LEKIVGELKKENSDLSEKLEY 1848 Query: 119 ---EREQLL--IKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTA 173 + ++LL ++ S+ + S E + R ED V +V D +R L +E +++ Sbjct: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSR--EDIGDNVAKVNDSWKERFLDVENELSR 1906 Query: 174 AQAE----------LEKAFAGTETEK-ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRL 222 ++E LE +TEK L E+K + + E +++V E+++L Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE---ELSVVTSERNQL 1963 Query: 223 IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM--- 279 EL K AL Q L E+ + E+ S L + A E KE+ TE Q Sbjct: 1964 RGELDTMSKKTTALDQ-LSEKMKEKTQELESHQSECLHCIQVAEAEVKEK-TELLQTLSS 2021 Query: 280 ---EHQKERNSFEERIQALEEDLR----------------EKEREIATEKKNSLKR---- 316 E K++ +E++Q+LE+D + KE+E+ ++ SL+ Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081 Query: 317 --------DKAIQG-------LTMALKSKEKKVEELNSEIEKL----SAAFAKAREALQK 357 KA++ + L S +++V +L IEKL A K +K Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141 Query: 358 AQTQEFQGSEDYETALSGKEALSAALRSQNL-------------TKSTENHRLRRSIKKI 404 + +E + + + + L + +Q L T T+ + RS+K Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201 Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGD---CTIRDLRNEVEKLRNEVNEREKA----M 457 +L L+ E+E L K ++E + S+ D + + L E E+ ++ E K + Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261 Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLE 517 +N+ K L+E+ L ++++K +S D +++ ++ + + L A E + Sbjct: 2262 QNQLKE-LNEAVAALCGDQEIMKATEQSL---DPPIEEEHQLRNSIEKLRARLEADEKKQ 2317 Query: 518 LRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQES-DS 576 L C QQ S+ K + + E +++ + Q+ H + S Sbjct: 2318 L---------CVLQQLKESEHHADLLKGRVENLERELEIARTNQE---HAALEAENSKGE 2365 Query: 577 INNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC 636 + L+A++ + + LE DV++ +R E +E+++ +E L +S+ +I Sbjct: 2366 VETLKAKIEGMTQSLRGLELDVVT---IRSEKENLTNELQKEQERISELEIINSSFENIL 2422 Query: 637 LE-ENNRFQVEHFS---QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLS----CMGFQG 688 E E + Q++ S E L+ ++ +L + V L+ D + K +LS C+ + Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482 Query: 689 NGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGY 748 L + ++ I+ ED + Q L++ +E + L KN Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK------QKLEKKDEEISRL-----KNQI 2531 Query: 749 LRHTE--SKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806 + SK+S +G H + NL L E+ +L+S+ L+ E+L Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL--EQKIQVLQSKNASLQDTLEVLQSS 2589 Query: 807 LFLTEQEVSGEHLDGKT--EKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVP 864 E E+ +D + EK K + +T + H+ + + E Q +GE Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAK-----ETELQREMHEMAQKTAELQEELSGEKN 2644 Query: 865 KV-GLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPE-NLHGVPGWQAAL 922 ++ G ++ + + D L+ E T E E + +L H+ + G + A Sbjct: 2645 RLAGELQLLLEEIKSSKDQLK---ELTLENSE---LKKSLDCMHKDQVEKEGKVREEIAE 2698 Query: 923 LSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCN 982 L EA+K +L+ ++ + +E +T + + + E+ K+ Sbjct: 2699 YQL---RLHEAEKKHQALLLDTNKQY--EVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753 Query: 983 KQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSD 1042 ++L+ L ++E + + +K + + ++ E Sbjct: 2754 EELNNSLKATTQILE--------------------ELKKTKMDNLKYVNQLKKENERAQG 2793 Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSES 1102 + + + SCK+ E+ + L + + +VM T E Sbjct: 2794 KMK--------------LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839 Query: 1103 INTSNE-TEYLKQKIHDLETELEGYQNFIF---QLQKHSQCSEAIITVLCGTEGAQDGLS 1158 E E L++K + + L+ Y + + +L+K + E + LC + QD Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRG 2899 Query: 1159 KPKNG 1163 P G Sbjct: 2900 SPLLG 2904 Score = 79.7 bits (195), Expect = 2e-14 Identities = 177/829 (21%), Positives = 357/829 (43%), Gaps = 178/829 (21%) Query: 49 EETVSPTRAR--------NMKDFENQ-----ITELKKENFNLKLRIYFLEERMQQEFHGP 95 E+ V+P+R+ N F+N + +LK +N L+ +I LE R+Q Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308 Query: 96 TEHIYKTNIELKVEVESLKRELQEREQLLIKA-SKAVESLAE---------AGGSEIQRV 145 + K EL++++E K EL E+E++L K + V + A+ A +++++ Sbjct: 309 KGQVNKFQ-ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL 367 Query: 146 KEDARKKVQQVEDL---LTKRILLLEKDVTAAQAELEKAFAGTETEKA-LRLRLESKLSE 201 ED + Q E L ++I EK+ + +++F + E ++ RL +L + Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427 Query: 202 MKKMH---EGDL-AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV--- 254 K MH + +L + V + + +EE K L E Q + +++++ E + Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487 Query: 255 -------SSGELRGLCAAPREEKE-----RETEAAQMEHQKERNSFEERIQALEEDLREK 302 S + R +C E K +++ E + + S E ++ L+E + ++ Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547 Query: 303 EREIATEK---------------KNSLKR---------------DKAIQGLTMALKSKEK 332 E + EK ++ LK+ +K + L AL+ K+K Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607 Query: 333 KVEEL----------NSEIEKLSAAFAKAREALQK--------AQTQEFQGSEDYE---T 371 + EEL SE EKL +E LQ +TQ+ + E E T Sbjct: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 667 Query: 372 ALSGKEALSAALRS-QNLTKSTENHRLRRSIKKITQELS--DLQQERE----RLEKDLEE 424 +E LS +R+ N+ S +S++ TQ+L+ +LQQ+ E + +K++E Sbjct: 668 LEMDRENLSVEIRNLHNVLDS-------KSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720 Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRY------KSLLSESNKKLHNQEQV 478 + S+ + DL ++++ L NE+ ++++ ++ + + LL + L E Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780 Query: 479 IKHLTESTNQKDVLLQKF-----NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533 + L + +Q+ + F + + + C L A D ++ ++ + S + Sbjct: 781 QRSLL-AFDQQPAMHHSFANIIGEQGSMPSERSECRLEA--DQSPKNSAILQNRVDSLE- 836 Query: 534 PGSKTIFSKEKKQSSDY----EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA 589 +K+ +SD EEL+Q+ + +I +L+K+ Q S AE ++ + Sbjct: 837 ----FSLESQKQMNSDLQKQCEELVQI---KGEIEENLMKAEQMHQS---FVAETSQRIS 886 Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD--QTSYLSIC-LEENNRFQVE 646 +L++D ++QN+ + E +S + +E+E L +D +T I L+++N + Sbjct: 887 ---KLQEDTSAHQNV---VAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLED 939 Query: 647 HFSQEEL--------KKKVSDLIQL----VKELYTDNQHLKKTIFDLSCMGFQGNGFPDR 694 + +L KK++S +I L ++EL +N LK+ L+ ++ Sbjct: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN---------QEK 990 Query: 695 LASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGG 743 + +++E A+ DE + I+ LSDQ+ Q+ +++ + G Sbjct: 991 MNLIQKSESFANYIDE------REKSISELSDQYKQEKLILLQRCEETG 1033 Score = 74.7 bits (182), Expect = 8e-13 Identities = 299/1456 (20%), Positives = 558/1456 (38%), Gaps = 214/1456 (14%) Query: 234 EALIQCLKEE----KSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289 E L+EE K + P + V EL LC R+ E+ E +ME Q + E Sbjct: 1525 EVFCSSLQEENLTRKETPSAPAKGVE--ELESLCEVYRQSLEKLEE--KMESQGIMKNKE 1580 Query: 290 ERIQALEEDLREKEREIATEKKNSLKRDKAIQG-LTMALKSKEKKVEELNSEIEKLSAAF 348 IQ LE+ L + +E+ +K L ++ Q LT E K+ + E+LS Sbjct: 1581 --IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL 1638 Query: 349 AKAREALQ--KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQ 406 AR LQ ++ G D E A+ G+ S + ++ +++TE R+ K Sbjct: 1639 EVARLQLQGLDLSSRSLLGI-DTEDAIQGRNE-SCDISKEHTSETTE-----RTPKHDVH 1691 Query: 407 ELSDLQQERERLEKDLE---EAHREKSKGDCTIRDL---------RNEVEKLRNEVNERE 454 ++ D +++ L D+E E K G+C+ ++ + ++E Sbjct: 1692 QICDKDAQQD-LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELS 1750 Query: 455 KAMENRYKSLLSESNKK-LHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAA 513 + N + N++ +HN + +K E++N+ LL ++D +V + Sbjct: 1751 FSGPNALVPMDFLGNQEDIHNLQLRVK---ETSNENLRLLHVIEDRDRKVESLLNEMKEL 1807 Query: 514 ED-LELRSEGLIT--EKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKS 570 + L L+ L+T E C + I + KK++SD E ++ + + L++ Sbjct: 1808 DSKLHLQEVQLMTKIEACIELEK-----IVGELKKENSDLSEKLEYFSCD---HQELLQR 1859 Query: 571 LQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT----LEEQISEIRRR----EEES 622 ++ S+ +N+ E++ + R+ + +V + K +E ++S IR E E+ Sbjct: 1860 VETSEGLNS-DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918 Query: 623 FSLYSD----QTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678 L +D QT L + + N+ +V +EEL S+ QL EL D K T Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL--DTMSKKTTA 1976 Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDE--DTIKIGEDD--EINFLSDQHLQQSNE 734 D + E+T+ L S + E I++ E + E L +E Sbjct: 1977 LDQLSEKMK-----------EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE 2025 Query: 735 IMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPD 794 ++KD + H + K+ + L + N +A L EK L+ ES Sbjct: 2026 LLKDKT----------HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES--- 2072 Query: 795 LLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCE 854 E L Q L+E + ++ E +KGE ++ +S + +L+ E Sbjct: 2073 ------ESL--QARLSESDYEKLNVSKALEAALVEKGEFA--LRLSSTQEEVHQLRRGIE 2122 Query: 855 AQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHG 914 V+ K L A + E ++ ++K N + EN Sbjct: 2123 KLRVRIEADEKKQLHIAEKLK----------ERERENDSLKDKVENLERELQMSEENQE- 2171 Query: 915 VPGWQAALLSLPGITNREAKKSRLPILIKP-SRSLG----NMYRLPATQEVVT----QLQ 965 L + N +A+ L I+ +RSL ++ L + +E +T + Q Sbjct: 2172 --------LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223 Query: 966 SQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQK 1025 Q+ EL L FK+ ++ Q I + E T + L N + A G+Q+ Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEI---QIKEESKTAVEMLQNQLKELNEAVAALCGDQE 2280 Query: 1026 GIKTTSSVWRDKEMDSDQQRSYEIDS-----EICPPDDLASLPSCKENPE--DVLSP--- 1075 +K T D ++ + Q I+ E L L KE+ D+L Sbjct: 2281 IMKATEQSL-DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339 Query: 1076 ---------------TSVATYLSSKSQPSAKVSVMGTDQS-------------ESINTSN 1107 ++ S + K + G QS E N +N Sbjct: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399 Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQ--------KHSQCSEAIITVLCGTEGAQDGLSK 1159 E + +++I +LE ++N + + + K S E + T L L Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459 Query: 1160 PKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN----LKQQLEEQEYKLQK 1215 + +E SS + ++ ++L L + VL++ L Q++E+ + KL+K Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519 Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275 + +L ++I + + LS + + + + L L+ ++ I V+ Q N Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE-QNLELRNLTVELEQKIQVL--QSKN 2576 Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAEL--LEKLEKLFLNGKSVGVEMNTQNELM 1333 ++ E+LQ+S + L EL ++K+ + K E Q E+ Sbjct: 2577 ASLQDTLEVLQSS----------YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626 Query: 1334 ERIEEDNLTYQHLLPESPEPSAS-HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQ 1392 E ++ + L E + L + S K +++E +K+ ++ Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQV 2686 Query: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEI 1452 + + +EI + RL E+ K ++ L +Q +Q S E SS EI Sbjct: 2687 EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEI 2746 Query: 1453 HFLRKQNQALNAMLI----------KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVK 1502 L+ + LN L K D K ++L++ R ++ L + ++ Sbjct: 2747 DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLE 2806 Query: 1503 EENERLQKEGSE----KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558 EE E LQKE S+ +E+ + + + + + ++E + ++ + D+ L Sbjct: 2807 EEKEILQKELSQLQAAQEKQKTGTVMDTKVD-ELTTEIKELKETLEEKTKEADEYLDKYC 2865 Query: 1559 VELKAYEKLDEEHRRL 1574 L ++EKL++ L Sbjct: 2866 SLLISHEKLEKAKEML 2881 Score = 66.2 bits (160), Expect = 3e-10 Identities = 356/1851 (19%), Positives = 698/1851 (37%), Gaps = 336/1851 (18%) Query: 64 ENQITELK----KENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 +N++ +LK KE+ ++ F EER Q +EL+ ++L+ E+ + Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLM-----------LELETVQQALRSEMTD 1116 Query: 120 REQLLIKASKAVESLAEAGG--SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAE 177 + S +EAGG EI +KE+ K ++V DLL + L++ T + + Sbjct: 1117 NQN---------NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1167 Query: 178 LEKAFAGTETEKALRLRLESKLSEMKKMH---EGDLAMALV-LDEKDRLIEELKLSLKSK 233 E+E +R ++ + SE + + + DL + + LD + + +L+ L++K Sbjct: 1168 ------NLESEP-IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220 Query: 234 EALIQ-------CLKEEKSQMACPDE-----NVSSGELRGL--CAAPREEK--------- 270 E +Q CL+ E + E ++ S E+ GL C EEK Sbjct: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280 Query: 271 --ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328 + + Q Q N E ++ + E L+ ++ E+ TE +S R + I A + Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNE-LEKICEILQAEKYELVTELNDS--RSECIT----ATR 1333 Query: 329 SKEKKVEELNSEIEKLSAAFAKAR-EALQKAQTQEF--QGSEDYETALSGKEALSAALRS 385 ++V +L +E++ L+ E ++ EF Q +E + +L+ Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAP---------- 1383 Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 L +S L S K++ ++LQ++ L+ + + H + + + +L+ V+ Sbjct: 1384 --LDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS 1441 Query: 446 LRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ 505 L+ E + N L+ E L +E ++ L+ S L + Sbjct: 1442 LKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSSSLSSLGDSSF---- 1495 Query: 506 QNCYLMAAEDLELRS--EGLITEK--------CSSQQPPG--SKTIFSKEKKQSSDYEEL 553 L D+ L S EG ++ CSS Q K S K + E L Sbjct: 1496 YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESL 1555 Query: 554 IQVLKKEQDIYTHLVKSLQESDSINNLQA-ELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612 +V ++ + L + ++ + N + EL ++ + +Q E D L Q L Sbjct: 1556 CEVYRQSLE---KLEEKMESQGIMKNKEIQELEQLLSSERQ-ELDCLRKQYLS------- 1604 Query: 613 SEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQ 672 E E + Q S+ LE ++ E E+L L + Sbjct: 1605 ------ENEQW-----QQKLTSVTLEMESKLAAEKKQTEQLS------------LELEVA 1641 Query: 673 HLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQS 732 L+ DLS G D + ++ ++ + +T + +++ + D+ QQ Sbjct: 1642 RLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQ- 1700 Query: 733 NEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792 ++ D+ K + G ++ T +C G +P E P +K E Sbjct: 1701 -DLNLDIEKI-TETGAVKPT----GECSGEQSPDTNYE--------PPGEDKTQGSSECI 1746 Query: 793 PDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF---SKPHDEL 849 +L L+ FL QE +L + ++T + L+H ++ S ++ Sbjct: 1747 SELSFSGPNALVPMDFLGNQE-DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805 Query: 850 KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRP 909 +L + L + + K+ +A ++ G+L + + + + S +H+ Sbjct: 1806 ELDSKLHLQEVQLMTKI---EACIELEKIVGELKKENSDLSEKL-------EYFSCDHQE 1855 Query: 910 ENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS--RSLGNMYRLPATQEVVTQLQSQ 967 L + E S L + S +G+ +V + + Sbjct: 1856 --------------LLQRVETSEGLNSDLEMHADKSSREDIGDN-----VAKVNDSWKER 1896 Query: 968 ILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGI 1027 L+++ EL ++ + + + EA +E T +K L +D+ +QK I Sbjct: 1897 FLDVENELSRIRSEKASIEHEALYLEADLEVVQT-EKLCLE---------KDNENKQKVI 1946 Query: 1028 KTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPS-CKENPEDVLSPTSVATYLS--S 1084 + +Q R E+D+ L L KE +++ S S + + Sbjct: 1947 VCLEEELSVVTSERNQLRG-ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005 Query: 1085 KSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY-------QNFIFQLQKHS 1137 +++ K ++ T S+ + +L++K+ LE + + +N I QL K Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065 Query: 1138 QC----SEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS--------SLHQVRYVKHVKI 1185 + SE++ L ++ + +SK + E+ F+ +HQ+R Sbjct: 2066 ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125 Query: 1186 LGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYD-- 1243 + A E + E LK++ E + K +NL +L N + D + + Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVE 2185 Query: 1244 ---SLVQSQARELSLQR--------------QQIKDGHGICVISRQHMNTMIKAFEELL- 1285 + ++ AR L + +QI++ G ++ ++ +F+ LL Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSFKSLLE 2241 Query: 1286 -------QASDVDYCVAEGFQEQLNQCAELLEKL----EKLFLNGKSVGVEMNTQNELME 1334 Q + E Q QL + E + L E + +S+ + +++L Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301 Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEK-SFFSRDQKQDNETEKTSVMVNSFSQD 1393 IE+ E+ E L + SE + + + ++ E E N Sbjct: 2302 SIEKLRARL-----EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356 Query: 1394 LLMEHIQ-EIRTLRKRLE---ESIKTNE----KLRKQLERQGSEFVQGSTSIFASGSELH 1445 L E+ + E+ TL+ ++E +S++ E +R + E +E + I SEL Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI----SELE 2412 Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505 +S + L+++ Q M K S + +L+E R V+ H +E KE+N Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER--VAALHNDQEACKAKEQN 2470 Query: 1506 ERLQKE-----------GSEKERHN--------QQLIQEVRCSGQELSRVQEEVKLRQQL 1546 Q E G ++ ++N LIQEV Q+L + EE+ + Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530 Query: 1547 LSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETP 1606 + ++L+ L ++ E++ LR+ +E + + S A S+ +T Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRN---LTVELEQKIQVLQSKNA----SLQDTL 2583 Query: 1607 PLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQ 1666 + + +L + L +K + + +E + + ++ Q Sbjct: 2584 EVLQSSYKNLE-------------------NELELTKMDK--MSFVEKVNKMTAKETELQ 2622 Query: 1667 RLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSL 1726 R + EM +T E S G K L + + ++K L+E L L Sbjct: 2623 REMHEMAQKTAELQEELS---GEKNRLAGELQLLLEEIKSSKDQLKEL-----TLENSEL 2674 Query: 1727 PEDGQCPLHCEQI---GEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774 + C +H +Q+ G+++ E+ + +L E EKK Q LL +K+ E Sbjct: 2675 KKSLDC-MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ--ALLLDTNKQYE 2722 Score = 52.4 bits (124), Expect = 4e-06 Identities = 293/1575 (18%), Positives = 571/1575 (36%), Gaps = 259/1575 (16%) Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356 + ++E E ++ KK +R + L AL+ +++KVE +E L Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL------------ 65 Query: 357 KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE 416 K + Q E E+ K+ +S L+ + + + +L K+I + L+QE + Sbjct: 66 KRENQRLM--EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK----LEQELK 119 Query: 417 RLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQE 476 R + +LE + + D ++ + + + ++Y+ L + NK++ ++ Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179 Query: 477 QV---IKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533 ++ +K L + + N +D+ Q + + + + + S + + + Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239 Query: 534 PGSKTIFSKEKKQSSDYEELIQVLKKEQDIY-------THLVKSLQ-ESDSINNLQAELN 585 S + FS E++ + L Q+ K++ + HL+ L+ ++ + N EL Sbjct: 240 DFSASYFSGEQEVTPSRSTL-QIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298 Query: 586 -KIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQ 644 ++ K+++ V +Q L+ LE+ E+ +E+ L+ C +E R Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEK-----------VLNKCRDELVRTT 347 Query: 645 VEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQG-----NGFPDRLASTE 699 ++ ++ K + L Q +K+L D ++ C Q F + L S + Sbjct: 348 AQY---DQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL-SRQ 403 Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759 Q ++ +K E+ + H E+ K S L + K+ Sbjct: 404 QRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463 Query: 760 DGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVR---ELLLGQLFLTEQEVSG 816 + A ++E + + E L S +V EL + L + + Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523 Query: 817 EHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLS---------CEAQLVKAGEVPKVG 867 E + K +L + S ++LKL+ C L+K E Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQ 583 Query: 868 LKDASVQTVATEGDLL---RFKHEATREAWEEKPINTALSAEHRP---------ENLHGV 915 L D +T LL K + E EEK + + +E+ ENL Sbjct: 584 LNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643 Query: 916 PGWQAALLSLPGITNREAKKSRLPILIKPSRSLG----NMYRLPATQEVVTQLQS-QILE 970 L I + E + R+ L +L N++ + ++ V + Q +E Sbjct: 644 INHLETCLKTQQIKSHEYNE-RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME 702 Query: 971 LQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTT 1030 LQ + EF + Q HQK I + + T G+ + ++ Sbjct: 703 LQ-QKAEF---SDQKHQKEIENMCLKTSQLT--------------------GQVEDLEHK 738 Query: 1031 SSVWRDKEMDSDQ-----QRSYEIDSEICPPDDLASLPSCKENPEDVLS----PTSVATY 1081 + ++ MD D+ YE ++ D ASL + +++ +L+ P ++ Sbjct: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD-ASLVTNEDHQRSLLAFDQQPAMHHSF 797 Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141 + + + S + E+ + + L+ ++ LE LE + LQK QC E Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK--QCEE 855 Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR---- 1197 + + K + M +HQ + + + L + + Sbjct: 856 LV---------------QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900 Query: 1198 ----VLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQAREL 1253 LEN +++L+ K++ EQ +L H L++ ++L Q + L Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL---------QLLSETL 951 Query: 1254 SLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE 1313 SL+++++ +IS + EEL Q + + LNQ E + ++ Sbjct: 952 SLEKKEMSS-----IISLNK-----REIEELTQENGT----LKEINASLNQ--EKMNLIQ 995 Query: 1314 KLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD 1373 K + + +EL ++ +++ L L E + ++ Sbjct: 996 KSESFANYIDEREKSISELSDQYKQEKLIL---------------LQRCEETGNAYEDLS 1040 Query: 1374 QKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG 1433 QK EK NS + LL E + LE+ L++ ++ EF+ Sbjct: 1041 QKYKAAQEK-----NSKLECLLNECTSLCENRKNELEQ-------LKEAFAKEHQEFL-- 1086 Query: 1434 STSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEH 1493 + A E + +L E+ ++ QAL + + + + E L++ + Sbjct: 1087 --TKLAFAEERNQNLMLELETVQ---QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141 Query: 1494 LQREYASVKEENERLQK----------------EGSEKERHNQQ-----------LIQEV 1526 +Q+E + +ENE+L K S KER +++ ++E+ Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEI 1201 Query: 1527 RCSGQELSRVQEEVKLRQQ--LLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMES 1584 VQ E LR + L +++K + L+ EL+ + D E L+D M+S Sbjct: 1202 SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI-RGDLETSNLQD-----MQS 1255 Query: 1585 DNSFDLFDSSQAVTPKSVSETPPL--SGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWAS 1642 L D K +S L S ND L C S T+ ++ L + + Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC---SLQTTMNKLNELEKICEILQA 1312 Query: 1643 KNGRHVLGL----IEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQEL-----GTKGPH 1693 + V L E A K + +LL E+ I ++ + + G G Sbjct: 1313 EKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQ 1372 Query: 1694 PAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKL 1753 P VS A L +Y L L D + +H ++ E + HK L Sbjct: 1373 P----NEQHPVSLAPLDESNSYEHLTL-------SDKEVQMHFAELQEKFLSLQSEHKIL 1421 Query: 1754 FEQEKKLQNTMKLLQ 1768 +Q ++ + M LQ Sbjct: 1422 HDQHCQMSSKMSELQ 1436 Score = 47.4 bits (111), Expect = 1e-04 Identities = 72/359 (20%), Positives = 149/359 (41%), Gaps = 38/359 (10%) Query: 1455 LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSE 1514 L + + L ++ ++ + + DKL++ ++ L+ L+ K++ E + EG+ Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64 Query: 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574 +R NQ+L++ + ++ E+++++ ++ + L S + K EKL++E +R Sbjct: 65 LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK---KQIEKLEQELKRC 121 Query: 1575 RDGDKYPMESDNSFDLFDSSQAVTPKSVSETP-----PLSGNDTDSLSCDSGSSATSTPC 1629 + + ++ S D+ + TP+ + TP SG+ + L Sbjct: 122 KSELERSQQAAQSADV-SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180 Query: 1630 VSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP---SSTSQE 1686 + V L A K + + ++ + I++ Q + Q ++ P SS SQ Sbjct: 181 LEAEVKA--LQAKKASQTLPQATMNH----RDIARHQASSSVFSWQQEKTPSHLSSNSQR 234 Query: 1687 LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEV 1746 + A V+ ++ TL+ R S ++ P + ++KA+ Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDA----NSSFFDNSSSP---HLLDQLKAQN 287 Query: 1747 TKLHKKLFEQEKKLQ----------NTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNL 1795 +L K+ E E +LQ N + LQL + KV +L+ K+L K R L Sbjct: 288 QELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV---ELIEKEKVLNKCRDEL 343 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 110 bits (276), Expect = 1e-23 Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V Sbjct: 858 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 911 Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144 + + K+EL+E +QL + K + + EA ++Q Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971 Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181 K A K++++ED L+K LLE+ D+T AE L+ Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031 Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236 +E +RL+ E K L ++K+ EGD + + + I ELK+ L KE Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091 Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294 +Q N EL G + +E+ + E AA+ + +K++ E ++A Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1150 Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354 L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207 Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 L + Q ++F+ ++ A L T EN L ++ + Q +++ + Sbjct: 1208 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253 Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467 +++LE ++E + S G+ +L ++V KL+NEV NE E K + S Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313 Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527 S++ QE + + + N L Q E++ Q + + A ++LE L + Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1372 Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582 S KK+ D+ ++ L++ + + +++L +++ + + L+ Sbjct: 1373 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R Sbjct: 1421 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473 Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693 + E +E L + + + ++ +EL N+ LK + DL S G + Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533 Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721 R T+ E+ E+ ED ++ ED ++ Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKL 1563 Score = 96.7 bits (239), Expect = 2e-19 Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%) Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96 L N++EE +K+ E+ I+EL K+E +L E+++++ G Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1064 Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156 ++ +L+ ++ LK +L ++E+ L A ++ + +++++E Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124 Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204 EDL ++R L +++ A + ELE T T++ LR + E +++ +KK Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184 Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 HE + A ++E +E+ K + + + Q L++E + +A Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1237 Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315 GELR L A +E +EH+K++ E ++Q L+ + ER A K Sbjct: 1238 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1284 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375 ++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1340 Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435 E +L+ Q + L R I + +LSD +++ + +E K + Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL + Sbjct: 1401 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 E I+ K + ++ KE K S L + Sbjct: 1460 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1494 Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615 L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+ Sbjct: 1495 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544 Query: 616 RRREEE 621 + + EE Sbjct: 1545 KTQLEE 1550 Score = 92.8 bits (229), Expect = 3e-18 Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%) Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134 L++ EE MQ E E K ELK E+E +L E + LL + +A E Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194 AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+ Sbjct: 904 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 942 Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254 +E KKM + L + L+E++ ++L+L + EA I+ L++E M + + Sbjct: 943 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997 Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314 S KER EERI L +L E+E + K Sbjct: 998 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030 Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374 K + I L + LK +EK +EL KL + E + Q Q + + L+ Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1086 Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433 K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K + Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1138 Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490 RDL E+E L+ E +E+ S ++ + +++V K L E T + Sbjct: 1139 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191 Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540 +Q+ +K + +++ + A +L+ + L E + + Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251 Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595 K+KK + +EL + L +D ++ LQ E+ + + + E Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1305 Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642 +DV S Q+ ++ L+E+ +++R+ EEE SL + Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365 Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702 + + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1419 Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757 ++ ++ DD + L +Q +++ +L K K L E IS Sbjct: 1420 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469 Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811 + D A A +E ++L L +A LE +LK E L+ + E Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529 Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871 E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+ Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1583 Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897 Q L R HE E +E+ Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDER 1609 Score = 79.3 bits (194), Expect = 3e-14 Identities = 124/635 (19%), Positives = 255/635 (40%), Gaps = 129/635 (20%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 ++D + + E ++ N+ ++ LEE + + + L+ + +L +L + Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375 Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179 ++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+ Sbjct: 1376 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1430 Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224 + ++ L LE K + ++ E + DE+DR L Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490 Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284 L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + + Sbjct: 1491 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547 Query: 285 RNSFEERIQA------------------------------------LEEDLREKEREIAT 308 E+ +QA L+ L E E E+ Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607 Query: 309 EKKN------------------SLKRDKAIQGLTMALKSKEK---KVEELNSEIEKLSAA 347 E+K L+ D AI+G A+K K ++++ E+E A+ Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667 Query: 348 ----FAKAREALQKAQTQE---FQGSEDYETALSGK-----------EALSAALRSQNLT 389 FA A+E +KA++ E Q ED A + E L+++L +N Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727 Query: 390 KSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDCT 435 + E RL I ++ +EL + Q Q+ E+L +L K + Sbjct: 1728 QD-EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 + L + ++LR++++E E A+++++KS ++ K+ E+ ++ + +K + Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE---QEAREKQAATKS 1843 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 +KD ++ + L+ ED E + E+ Q G+ + +++ EE + Sbjct: 1844 LKQKDKKLKE---ILLQVED-----ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895 Query: 556 VLKKEQDIYTHLVKSLQESDS----INNLQAELNK 586 + + + L ++ + +++ +N L+++L + Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930 Score = 79.0 bits (193), Expect = 4e-14 Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%) Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315 +++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+ Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 893 Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367 + + + L +K++++EE+ E+E + LQ + + Q Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953 Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424 D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013 Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474 E+ + + L+N+ E + +E+ R K E + + L + +KL Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1072 Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532 Q Q+ + + +++ L D E+ Q+N L +L EG I++ + Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1126 Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591 + +K +KQ D E ++ LK T L +L + + L+A+ ++ L+ Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1180 Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641 K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N Sbjct: 1181 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233 Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682 + +VEH + +EL+ K SD + EL L+ + ++ Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293 Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729 M + G +LA + T+ L +E + + ++E N L DQ L Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1352 Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783 + E ++L + N L ++ K+ D A LEEG I L + E Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1410 Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841 KA LE + L+ + L+ L Q VS +L+ K K + E + N Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1463 Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 SK DE + EA+ + E + L A + + + +L E T + + + + Sbjct: 1464 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1516 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 S + +N+H + + AL T E K++L L L AT++ Sbjct: 1517 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1562 Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 +L+ + L+G+ ++ + ++Q +K + + T + + AA + Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622 Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079 G+ K ++ S + +E Q R + + D L + + +++ + T+ Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1677 Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138 +KS A + + D + + + + K+++ +L + L G LQ + Sbjct: 1678 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1732 Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198 EA I L E ++ + SD Q + LA E ++ Sbjct: 1733 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1782 Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 E+ +QQLE Q N +L S++H ++ + ++ S + + +++ + Sbjct: 1783 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1828 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 Q++ + + + K +E+L + + +AE ++EQ + +++L++ Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888 Query: 1319 GKSVGVEMNTQNELMER 1335 + +N ++R Sbjct: 1889 AEEESQRINANRRKLQR 1905 Score = 77.0 bits (188), Expect = 2e-13 Identities = 218/1220 (17%), Positives = 467/1220 (38%), Gaps = 148/1220 (12%) Query: 296 EEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREAL 355 EE+++ KE E+ K+ K + LK E+K +L E L +E L Sbjct: 851 EEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEEKNLL-------QEQL 896 Query: 356 QKAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHR---LRRSIKKITQELSDL 411 Q A+T+ + +E+ L+ K + L L E R L+ KK+ Q++ DL Sbjct: 897 Q-AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955 Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEV---EKLRNEVNEREKAMENRYKSLLSES 468 +++ E E ++ EK + I+ L +E+ + N++++ K +E R +S+ Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER----ISDL 1011 Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKC 528 L +E+ K+LT+ N+ + ++ +E ++ + ++ E L+ + EG ++ Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKRKLEGDASD-- 1066 Query: 529 SSQQPPGSKTIFSKEKKQSSDYEELIQV----LKKEQDIYTHLVKSLQESDS-INNLQAE 583 +Q + ++ K Q + EE +Q L E + +K ++E + I++LQ + Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126 Query: 584 LNKIFALRKQLEQ---DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640 L+ A R + E+ D+ KT E + ++E + + + L L+E Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186 Query: 641 NRFQVEHFSQ-EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699 R H +Q +E+++K + Q V+EL + K+ +L D+ T Sbjct: 1187 TR---SHEAQVQEMRQKHA---QAVEELTEQLEQFKRAKANL-----------DKNKQTL 1229 Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759 + E A E + E+ + Q E+ S G L K+ + Sbjct: 1230 EKEN-ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN- 1287 Query: 760 DGAHAPGCLEE--GAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGE 817 + G L E G I L + + ++ L +++ L + R+ L L + E Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346 Query: 818 HLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGL-KDASVQTV 876 L + ++ + K L + T + + KL A V+A E K K+ T Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406 Query: 877 ATEGDLLRF-KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKK 935 E + K E T+ +++ + + +++ + ++N E K+ Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----------------VSNLEKKQ 1450 Query: 936 SRLPILIKPSRSLGNMY--RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993 + L+ +++ + Y + + +++ L L L+E ++L + + + Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510 Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053 A ME L++++ VG + ++ ++T Sbjct: 1511 AEMED-------LVSSKDDVGKNVHELEKSKRALET------------------------ 1539 Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113 + + + E ED L T A + + K Q+ + L+ Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595 Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSS 1173 +++H+ ETELE + + A +K K D +++ + Sbjct: 1596 RQLHEYETELEDERK----------------------QRALAAAAKKKLEGDLKDLELQA 1633 Query: 1174 LHQVRYVKH-VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231 ++ + +K L L +M D R LE+ + +E ++ + L +++ LQ Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693 Query: 1232 NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVD 1291 R + ++ + EL+ + G ++ + I EE L+ + Sbjct: 1694 EDLAAAERARKQADLEKE--ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751 Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESP 1351 E +++ + + E+L +S + + + +ER ++ + H + + Sbjct: 1752 M---EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808 Query: 1352 EPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRL 1409 + ++ E + +++ E + + + + L ++ +++ R + ++ Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868 Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469 +E + KQL+RQ E + S I A+ +L L + +NA+ K Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928 Query: 1470 SRDKQKENDKLRESLSRKTV 1489 R + R S R+ + Sbjct: 1929 RRGNETSFVPSRRSGGRRVI 1948 Score = 72.4 bits (176), Expect = 4e-12 Identities = 103/466 (22%), Positives = 197/466 (42%), Gaps = 85/466 (18%) Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140 LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E Sbjct: 1492 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1542 Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199 E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L Sbjct: 1543 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598 Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251 E + E + AL K +L +LK ++K +E I+ L++ ++QM Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658 Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304 + A R+E A E++K+ S E + L+EDL ER Sbjct: 1659 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708 Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343 E+A E +SL A+Q L+++ ++EE + E+ Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768 Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385 LS A R QK ++ E +G+ +++ ++ EA A L Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828 Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+ Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888 Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488 E +N + ++ R +ESN+ + + +K N+ Sbjct: 1889 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNE 1933 Score = 62.8 bits (151), Expect = 3e-09 Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%) Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842 E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++ Sbjct: 908 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964 Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 ++ +L K++ EA++ K L+D + + + + L + + E + N Sbjct: 965 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1015 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 A E + +NL + +++S + ++ +KSR L K R L + Sbjct: 1016 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1064 Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021 + QI +LQ ++ E K + ++L A A ++ L Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1110 Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081 K I+ D + D D +R+ +E D L + K ED L T+ Sbjct: 1111 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167 Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137 L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+ Sbjct: 1168 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226 Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181 Q E L G + Q+ K K SDGE +V ++ Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286 Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235 + +L + I ++ + +L QL++ + LQ+E + + +++ L+ + Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346 Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293 L + + Q R +S Q+ D S++ + E L + Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1399 Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349 E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459 Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409 S+ +A D++ E E + S +E E + Sbjct: 1460 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1499 Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469 EE +TN+ L+ ++E S + +H L K +AL + + Sbjct: 1500 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1544 Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529 ++ D+L+ + K ++Q + + + ++ EK R Q+ + E Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1602 Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563 + +++E K R + KL L+ +EL+A Sbjct: 1603 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1633 Score = 60.1 bits (144), Expect = 2e-08 Identities = 229/1176 (19%), Positives = 445/1176 (37%), Gaps = 175/1176 (14%) Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503 E+++ + +E +K E + K+ +L EQ LTE N LQ E E Sbjct: 852 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906 Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563 + L AA+ EL E ++ + + ++ KK + +L + L++E+ Sbjct: 907 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965 Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618 L ++ + I L+ E+ + +L ++ RK LEE+IS++ Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1018 Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678 EE++ +L + + S+ E R + E S++EL+K L ++L D + I Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1071 Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738 DL E LA KE+E + L D+ Q++N + K Sbjct: 1072 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1112 Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798 +R E ISD L+E A EK L + LK Sbjct: 1113 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1153 Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857 E L T+QE+ + T K + H Q + H + QL Sbjct: 1154 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212 Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913 + K L D + QT+ E DL LR +A +E +K A E + + Sbjct: 1213 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270 Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962 G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++ Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1325 Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010 + Q L + +L++ + L +L + ME + ++ + LN Q Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382 Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062 V A + QK I+ + + +K D+ + E+D + D+ L Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442 Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109 S E + + Y + + A+ T E++ E Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502 Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164 E LK ++ DL + + + +L+K + E + + E +D L ++ Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562 Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224 E+ +L + ++ + ++ A + + L++QL E E +L+ E+ Sbjct: 1563 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616 Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272 + L+ +DL ++ +Q+Q ++ + + + + + Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676 Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331 K+ E L D AE ++Q + + EL E+L ++ E Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736 Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389 + ++EE+ L E E A+SD + + ++ NE TE+++ N Sbjct: 1737 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1784 Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449 ++ L +E+R+ +E ++K+ K + + ++ Q + E ++ Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842 Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER-- 1507 S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R Sbjct: 1843 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897 Query: 1508 -----LQKEGSEKERHNQQLIQEVRCSGQELSRVQE 1538 LQ+E E N+ + +EV +L R E Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933 Score = 57.0 bits (136), Expect = 2e-07 Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%) Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109 ET +++ E+++ + L++ + L+ + +++ E + +L+ + Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597 Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163 + + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ + Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1656 Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222 ++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L Sbjct: 1657 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713 Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263 EEL SL + AL + L+EE+ M + V +L Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773 Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302 A R ++ E+ Q+E Q KE S E +I LEE + ++ Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833 Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ + Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892 Score = 47.8 bits (112), Expect = 1e-04 Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%) Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153 DQ+ + S E + L+++I DL T L E +N KH + L E + Sbjct: 992 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049 Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213 + L K K +G+ F H +I + +++ E LK QL ++E +L Sbjct: 1050 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1092 Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261 Q ++ +N K R+L D + + Q R+L + + +K Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152 Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310 + S Q + + KA +E ++ + V E Q+ EL E Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1210 Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357 +LE+ K ++ + +E+ D + ++ E+ Sbjct: 1211 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266 Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417 SD E + + K NE E + M+N ++ ++ +++ +L +L+++ + Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1321 Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477 +L ++ RQ + + L L E+ + + ++ + I+ S K+K Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381 Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531 D L E R +E+L ++Y ++L+K + ++ L+ ++ Q Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441 Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566 +S ++++ + QLL++ + R E +A EK Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481 Score = 39.3 bits (90), Expect = 0.035 Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%) Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341 EE+ D E Q+ N+ EL +K +L + ++ + EL EE + Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911 Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401 E E L + E + R Q+ E +K + + L E ++E Sbjct: 912 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 961 Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461 R++L+ T E K+LE + + ++ L+ E L ++ Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1010 Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519 L L + +K K KL+ LE ++ ++E E+L++ EG + H Sbjct: 1011 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069 Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579 Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1122 Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639 ++ D DS +A K+ + L G + ++L + + ST L Sbjct: 1123 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1174 Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695 + + + +EA ++++ +Q L E Q + A ++ + T A Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234 Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737 L+ + + AK +E ++L+ L + S E + L+ + Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294 Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774 + E + + KL K + +LQ+T +LLQ RQ+ Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 110 bits (276), Expect = 1e-23 Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V Sbjct: 865 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 918 Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144 + + K+EL+E +QL + K + + EA ++Q Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978 Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181 K A K++++ED L+K LLE+ D+T AE L+ Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038 Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236 +E +RL+ E K L ++K+ EGD + + + I ELK+ L KE Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098 Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294 +Q N EL G + +E+ + E AA+ + +K++ E ++A Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1157 Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354 L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214 Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 L + Q ++F+ ++ A L T EN L ++ + Q +++ + Sbjct: 1215 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260 Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467 +++LE ++E + S G+ +L ++V KL+NEV NE E K + S Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320 Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527 S++ QE + + + N L Q E++ Q + + A ++LE L + Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1379 Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582 S KK+ D+ ++ L++ + + +++L +++ + + L+ Sbjct: 1380 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R Sbjct: 1428 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480 Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693 + E +E L + + + ++ +EL N+ LK + DL S G + Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540 Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721 R T+ E+ E+ ED ++ ED ++ Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKL 1570 Score = 96.7 bits (239), Expect = 2e-19 Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%) Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96 L N++EE +K+ E+ I+EL K+E +L E+++++ G Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1071 Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156 ++ +L+ ++ LK +L ++E+ L A ++ + +++++E Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131 Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204 EDL ++R L +++ A + ELE T T++ LR + E +++ +KK Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191 Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 HE + A ++E +E+ K + + + Q L++E + +A Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1244 Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315 GELR L A +E +EH+K++ E ++Q L+ + ER A K Sbjct: 1245 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1291 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375 ++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1347 Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435 E +L+ Q + L R I + +LSD +++ + +E K + Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL + Sbjct: 1408 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 E I+ K + ++ KE K S L + Sbjct: 1467 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1501 Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615 L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+ Sbjct: 1502 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551 Query: 616 RRREEE 621 + + EE Sbjct: 1552 KTQLEE 1557 Score = 92.8 bits (229), Expect = 3e-18 Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%) Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134 L++ EE MQ E E K ELK E+E +L E + LL + +A E Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194 AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+ Sbjct: 911 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 949 Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254 +E KKM + L + L+E++ ++L+L + EA I+ L++E M + + Sbjct: 950 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004 Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314 S KER EERI L +L E+E + K Sbjct: 1005 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037 Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374 K + I L + LK +EK +EL KL + E + Q Q + + L+ Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1093 Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433 K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K + Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1145 Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490 RDL E+E L+ E +E+ S ++ + +++V K L E T + Sbjct: 1146 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198 Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540 +Q+ +K + +++ + A +L+ + L E + + Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258 Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595 K+KK + +EL + L +D ++ LQ E+ + + + E Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1312 Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642 +DV S Q+ ++ L+E+ +++R+ EEE SL + Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372 Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702 + + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1426 Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757 ++ ++ DD + L +Q +++ +L K K L E IS Sbjct: 1427 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476 Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811 + D A A +E ++L L +A LE +LK E L+ + E Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536 Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871 E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+ Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1590 Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897 Q L R HE E +E+ Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDER 1616 Score = 79.3 bits (194), Expect = 3e-14 Identities = 124/635 (19%), Positives = 255/635 (40%), Gaps = 129/635 (20%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 ++D + + E ++ N+ ++ LEE + + + L+ + +L +L + Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382 Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179 ++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+ Sbjct: 1383 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1437 Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224 + ++ L LE K + ++ E + DE+DR L Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497 Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284 L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + + Sbjct: 1498 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554 Query: 285 RNSFEERIQA------------------------------------LEEDLREKEREIAT 308 E+ +QA L+ L E E E+ Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614 Query: 309 EKKN------------------SLKRDKAIQGLTMALKSKEK---KVEELNSEIEKLSAA 347 E+K L+ D AI+G A+K K ++++ E+E A+ Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674 Query: 348 ----FAKAREALQKAQTQE---FQGSEDYETALSGK-----------EALSAALRSQNLT 389 FA A+E +KA++ E Q ED A + E L+++L +N Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734 Query: 390 KSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDCT 435 + E RL I ++ +EL + Q Q+ E+L +L K + Sbjct: 1735 QD-EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 + L + ++LR++++E E A+++++KS ++ K+ E+ ++ + +K + Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE---QEAREKQAATKS 1850 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 +KD ++ + L+ ED E + E+ Q G+ + +++ EE + Sbjct: 1851 LKQKDKKLKE---ILLQVED-----ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902 Query: 556 VLKKEQDIYTHLVKSLQESDS----INNLQAELNK 586 + + + L ++ + +++ +N L+++L + Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937 Score = 79.0 bits (193), Expect = 4e-14 Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%) Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315 +++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+ Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 900 Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367 + + + L +K++++EE+ E+E + LQ + + Q Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960 Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424 D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020 Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474 E+ + + L+N+ E + +E+ R K E + + L + +KL Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1079 Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532 Q Q+ + + +++ L D E+ Q+N L +L EG I++ + Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1133 Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591 + +K +KQ D E ++ LK T L +L + + L+A+ ++ L+ Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1187 Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641 K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N Sbjct: 1188 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240 Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682 + +VEH + +EL+ K SD + EL L+ + ++ Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300 Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729 M + G +LA + T+ L +E + + ++E N L DQ L Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1359 Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783 + E ++L + N L ++ K+ D A LEEG I L + E Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1417 Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841 KA LE + L+ + L+ L Q VS +L+ K K + E + N Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1470 Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 SK DE + EA+ + E + L A + + + +L E T + + + + Sbjct: 1471 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1523 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 S + +N+H + + AL T E K++L L L AT++ Sbjct: 1524 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1569 Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 +L+ + L+G+ ++ + ++Q +K + + T + + AA + Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629 Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079 G+ K ++ S + +E Q R + + D L + + +++ + T+ Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1684 Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138 +KS A + + D + + + + K+++ +L + L G LQ + Sbjct: 1685 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1739 Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198 EA I L E ++ + SD Q + LA E ++ Sbjct: 1740 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1789 Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 E+ +QQLE Q N +L S++H ++ + ++ S + + +++ + Sbjct: 1790 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1835 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 Q++ + + + K +E+L + + +AE ++EQ + +++L++ Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895 Query: 1319 GKSVGVEMNTQNELMER 1335 + +N ++R Sbjct: 1896 AEEESQRINANRRKLQR 1912 Score = 77.0 bits (188), Expect = 2e-13 Identities = 218/1220 (17%), Positives = 467/1220 (38%), Gaps = 148/1220 (12%) Query: 296 EEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREAL 355 EE+++ KE E+ K+ K + LK E+K +L E L +E L Sbjct: 858 EEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEEKNLL-------QEQL 903 Query: 356 QKAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHR---LRRSIKKITQELSDL 411 Q A+T+ + +E+ L+ K + L L E R L+ KK+ Q++ DL Sbjct: 904 Q-AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962 Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEV---EKLRNEVNEREKAMENRYKSLLSES 468 +++ E E ++ EK + I+ L +E+ + N++++ K +E R +S+ Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER----ISDL 1018 Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKC 528 L +E+ K+LT+ N+ + ++ +E ++ + ++ E L+ + EG ++ Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKRKLEGDASD-- 1073 Query: 529 SSQQPPGSKTIFSKEKKQSSDYEELIQV----LKKEQDIYTHLVKSLQESDS-INNLQAE 583 +Q + ++ K Q + EE +Q L E + +K ++E + I++LQ + Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133 Query: 584 LNKIFALRKQLEQ---DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640 L+ A R + E+ D+ KT E + ++E + + + L L+E Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193 Query: 641 NRFQVEHFSQ-EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699 R H +Q +E+++K + Q V+EL + K+ +L D+ T Sbjct: 1194 TR---SHEAQVQEMRQKHA---QAVEELTEQLEQFKRAKANL-----------DKNKQTL 1236 Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759 + E A E + E+ + Q E+ S G L K+ + Sbjct: 1237 EKEN-ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN- 1294 Query: 760 DGAHAPGCLEE--GAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGE 817 + G L E G I L + + ++ L +++ L + R+ L L + E Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353 Query: 818 HLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGL-KDASVQTV 876 L + ++ + K L + T + + KL A V+A E K K+ T Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413 Query: 877 ATEGDLLRF-KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKK 935 E + K E T+ +++ + + +++ + ++N E K+ Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----------------VSNLEKKQ 1457 Query: 936 SRLPILIKPSRSLGNMY--RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993 + L+ +++ + Y + + +++ L L L+E ++L + + + Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517 Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053 A ME L++++ VG + ++ ++T Sbjct: 1518 AEMED-------LVSSKDDVGKNVHELEKSKRALET------------------------ 1546 Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113 + + + E ED L T A + + K Q+ + L+ Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602 Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSS 1173 +++H+ ETELE + + A +K K D +++ + Sbjct: 1603 RQLHEYETELEDERK----------------------QRALAAAAKKKLEGDLKDLELQA 1640 Query: 1174 LHQVRYVKH-VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231 ++ + +K L L +M D R LE+ + +E ++ + L +++ LQ Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700 Query: 1232 NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVD 1291 R + ++ + EL+ + G ++ + I EE L+ + Sbjct: 1701 EDLAAAERARKQADLEKE--ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758 Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESP 1351 E +++ + + E+L +S + + + +ER ++ + H + + Sbjct: 1759 M---EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815 Query: 1352 EPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRL 1409 + ++ E + +++ E + + + + L ++ +++ R + ++ Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875 Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469 +E + KQL+RQ E + S I A+ +L L + +NA+ K Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935 Query: 1470 SRDKQKENDKLRESLSRKTV 1489 R + R S R+ + Sbjct: 1936 RRGNETSFVPSRRSGGRRVI 1955 Score = 72.4 bits (176), Expect = 4e-12 Identities = 103/466 (22%), Positives = 197/466 (42%), Gaps = 85/466 (18%) Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140 LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E Sbjct: 1499 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1549 Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199 E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L Sbjct: 1550 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605 Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251 E + E + AL K +L +LK ++K +E I+ L++ ++QM Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665 Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304 + A R+E A E++K+ S E + L+EDL ER Sbjct: 1666 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715 Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343 E+A E +SL A+Q L+++ ++EE + E+ Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775 Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385 LS A R QK ++ E +G+ +++ ++ EA A L Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835 Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+ Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895 Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488 E +N + ++ R +ESN+ + + +K N+ Sbjct: 1896 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNE 1940 Score = 62.8 bits (151), Expect = 3e-09 Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%) Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842 E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++ Sbjct: 915 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971 Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 ++ +L K++ EA++ K L+D + + + + L + + E + N Sbjct: 972 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1022 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 A E + +NL + +++S + ++ +KSR L K R L + Sbjct: 1023 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1071 Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021 + QI +LQ ++ E K + ++L A A ++ L Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1117 Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081 K I+ D + D D +R+ +E D L + K ED L T+ Sbjct: 1118 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174 Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137 L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+ Sbjct: 1175 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233 Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181 Q E L G + Q+ K K SDGE +V ++ Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293 Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235 + +L + I ++ + +L QL++ + LQ+E + + +++ L+ + Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353 Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293 L + + Q R +S Q+ D S++ + E L + Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1406 Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349 E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466 Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409 S+ +A D++ E E + S +E E + Sbjct: 1467 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1506 Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469 EE +TN+ L+ ++E S + +H L K +AL + + Sbjct: 1507 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1551 Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529 ++ D+L+ + K ++Q + + + ++ EK R Q+ + E Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1609 Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563 + +++E K R + KL L+ +EL+A Sbjct: 1610 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1640 Score = 60.1 bits (144), Expect = 2e-08 Identities = 229/1176 (19%), Positives = 445/1176 (37%), Gaps = 175/1176 (14%) Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503 E+++ + +E +K E + K+ +L EQ LTE N LQ E E Sbjct: 859 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913 Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563 + L AA+ EL E ++ + + ++ KK + +L + L++E+ Sbjct: 914 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972 Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618 L ++ + I L+ E+ + +L ++ RK LEE+IS++ Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1025 Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678 EE++ +L + + S+ E R + E S++EL+K L ++L D + I Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1078 Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738 DL E LA KE+E + L D+ Q++N + K Sbjct: 1079 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1119 Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798 +R E ISD L+E A EK L + LK Sbjct: 1120 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1160 Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857 E L T+QE+ + T K + H Q + H + QL Sbjct: 1161 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219 Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913 + K L D + QT+ E DL LR +A +E +K A E + + Sbjct: 1220 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277 Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962 G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++ Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1332 Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010 + Q L + +L++ + L +L + ME + ++ + LN Q Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389 Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062 V A + QK I+ + + +K D+ + E+D + D+ L Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449 Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109 S E + + Y + + A+ T E++ E Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509 Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164 E LK ++ DL + + + +L+K + E + + E +D L ++ Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569 Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224 E+ +L + ++ + ++ A + + L++QL E E +L+ E+ Sbjct: 1570 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623 Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272 + L+ +DL ++ +Q+Q ++ + + + + + Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683 Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331 K+ E L D AE ++Q + + EL E+L ++ E Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743 Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389 + ++EE+ L E E A+SD + + ++ NE TE+++ N Sbjct: 1744 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1791 Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449 ++ L +E+R+ +E ++K+ K + + ++ Q + E ++ Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849 Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER-- 1507 S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R Sbjct: 1850 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904 Query: 1508 -----LQKEGSEKERHNQQLIQEVRCSGQELSRVQE 1538 LQ+E E N+ + +EV +L R E Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940 Score = 57.0 bits (136), Expect = 2e-07 Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%) Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109 ET +++ E+++ + L++ + L+ + +++ E + +L+ + Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604 Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163 + + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ + Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1663 Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222 ++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L Sbjct: 1664 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720 Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263 EEL SL + AL + L+EE+ M + V +L Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780 Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302 A R ++ E+ Q+E Q KE S E +I LEE + ++ Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840 Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ + Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899 Score = 47.8 bits (112), Expect = 1e-04 Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%) Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153 DQ+ + S E + L+++I DL T L E +N KH + L E + Sbjct: 999 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056 Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213 + L K K +G+ F H +I + +++ E LK QL ++E +L Sbjct: 1057 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1099 Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261 Q ++ +N K R+L D + + Q R+L + + +K Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159 Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310 + S Q + + KA +E ++ + V E Q+ EL E Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1217 Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357 +LE+ K ++ + +E+ D + ++ E+ Sbjct: 1218 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273 Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417 SD E + + K NE E + M+N ++ ++ +++ +L +L+++ + Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1328 Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477 +L ++ RQ + + L L E+ + + ++ + I+ S K+K Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388 Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531 D L E R +E+L ++Y ++L+K + ++ L+ ++ Q Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448 Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566 +S ++++ + QLL++ + R E +A EK Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488 Score = 39.3 bits (90), Expect = 0.035 Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%) Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341 EE+ D E Q+ N+ EL +K +L + ++ + EL EE + Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918 Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401 E E L + E + R Q+ E +K + + L E ++E Sbjct: 919 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 968 Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461 R++L+ T E K+LE + + ++ L+ E L ++ Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1017 Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519 L L + +K K KL+ LE ++ ++E E+L++ EG + H Sbjct: 1018 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076 Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579 Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1129 Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639 ++ D DS +A K+ + L G + ++L + + ST L Sbjct: 1130 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1181 Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695 + + + +EA ++++ +Q L E Q + A ++ + T A Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241 Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737 L+ + + AK +E ++L+ L + S E + L+ + Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301 Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774 + E + + KL K + +LQ+T +LLQ RQ+ Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 110 bits (276), Expect = 1e-23 Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V Sbjct: 865 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 918 Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144 + + K+EL+E +QL + K + + EA ++Q Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978 Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181 K A K++++ED L+K LLE+ D+T AE L+ Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038 Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236 +E +RL+ E K L ++K+ EGD + + + I ELK+ L KE Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098 Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294 +Q N EL G + +E+ + E AA+ + +K++ E ++A Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1157 Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354 L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214 Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 L + Q ++F+ ++ A L T EN L ++ + Q +++ + Sbjct: 1215 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260 Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467 +++LE ++E + S G+ +L ++V KL+NEV NE E K + S Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320 Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527 S++ QE + + + N L Q E++ Q + + A ++LE L + Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1379 Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582 S KK+ D+ ++ L++ + + +++L +++ + + L+ Sbjct: 1380 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R Sbjct: 1428 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480 Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693 + E +E L + + + ++ +EL N+ LK + DL S G + Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540 Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721 R T+ E+ E+ ED ++ ED ++ Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKL 1570 Score = 96.7 bits (239), Expect = 2e-19 Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%) Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96 L N++EE +K+ E+ I+EL K+E +L E+++++ G Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1071 Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156 ++ +L+ ++ LK +L ++E+ L A ++ + +++++E Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131 Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204 EDL ++R L +++ A + ELE T T++ LR + E +++ +KK Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191 Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 HE + A ++E +E+ K + + + Q L++E + +A Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1244 Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315 GELR L A +E +EH+K++ E ++Q L+ + ER A K Sbjct: 1245 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1291 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375 ++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1347 Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435 E +L+ Q + L R I + +LSD +++ + +E K + Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL + Sbjct: 1408 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 E I+ K + ++ KE K S L + Sbjct: 1467 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1501 Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615 L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+ Sbjct: 1502 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551 Query: 616 RRREEE 621 + + EE Sbjct: 1552 KTQLEE 1557 Score = 92.8 bits (229), Expect = 3e-18 Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%) Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134 L++ EE MQ E E K ELK E+E +L E + LL + +A E Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194 AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+ Sbjct: 911 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 949 Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254 +E KKM + L + L+E++ ++L+L + EA I+ L++E M + + Sbjct: 950 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004 Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314 S KER EERI L +L E+E + K Sbjct: 1005 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037 Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374 K + I L + LK +EK +EL KL + E + Q Q + + L+ Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1093 Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433 K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K + Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1145 Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490 RDL E+E L+ E +E+ S ++ + +++V K L E T + Sbjct: 1146 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198 Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540 +Q+ +K + +++ + A +L+ + L E + + Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258 Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595 K+KK + +EL + L +D ++ LQ E+ + + + E Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1312 Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642 +DV S Q+ ++ L+E+ +++R+ EEE SL + Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372 Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702 + + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1426 Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757 ++ ++ DD + L +Q +++ +L K K L E IS Sbjct: 1427 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476 Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811 + D A A +E ++L L +A LE +LK E L+ + E Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536 Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871 E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+ Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1590 Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897 Q L R HE E +E+ Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDER 1616 Score = 79.3 bits (194), Expect = 3e-14 Identities = 130/609 (21%), Positives = 255/609 (41%), Gaps = 81/609 (13%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 ++D + + E ++ N+ ++ LEE + + + L+ + +L +L + Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382 Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179 ++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+ Sbjct: 1383 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1437 Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224 + ++ L LE K + ++ E + DE+DR L Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497 Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284 L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + + Sbjct: 1498 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554 Query: 285 RNSFEERIQALEE-DLR----------EKEREI-ATEKKNSLKRDKAIQGLTMALKSKEK 332 E+ +QA E+ LR + ER++ A +++N KR + L L E Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR----RQLQRQLHEYET 1610 Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392 ++E+ + +AA K L+ + Q + E A+ L A ++ + + Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--DFQREL 1668 Query: 393 ENHRLRR-----SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL- 446 E+ R R + K+ ++ L+ + +L++DL A R + + D +L E+ Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728 Query: 447 --RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKF------NE 498 RN + + ++ +E R L E ++ N E + + ++T Q + L + + Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788 Query: 499 KDLEVIQQNCYLMAAEDLELRS-----EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553 K+ QQ + ++ ELRS EG + K S TI + E K + E++ Sbjct: 1789 KNESARQQ----LERQNKELRSKLHEMEGAVKSKFKS-------TIAALEAKIAQLEEQV 1837 Query: 554 IQVLKKEQDIYTHLVKSLQESDS-----INNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608 Q +++Q KSL++ D + ++ E ++Q E+ + L++ L Sbjct: 1838 EQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893 Query: 609 EEQISEIRR 617 EE E +R Sbjct: 1894 EEAEEESQR 1902 Score = 79.0 bits (193), Expect = 4e-14 Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%) Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315 +++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+ Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 900 Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367 + + + L +K++++EE+ E+E + LQ + + Q Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960 Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424 D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020 Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474 E+ + + L+N+ E + +E+ R K E + + L + +KL Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1079 Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532 Q Q+ + + +++ L D E+ Q+N L +L EG I++ + Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1133 Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591 + +K +KQ D E ++ LK T L +L + + L+A+ ++ L+ Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1187 Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641 K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N Sbjct: 1188 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240 Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682 + +VEH + +EL+ K SD + EL L+ + ++ Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300 Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729 M + G +LA + T+ L +E + + ++E N L DQ L Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1359 Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783 + E ++L + N L ++ K+ D A LEEG I L + E Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1417 Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841 KA LE + L+ + L+ L Q VS +L+ K K + E + N Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1470 Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 SK DE + EA+ + E + L A + + + +L E T + + + + Sbjct: 1471 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1523 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 S + +N+H + + AL T E K++L L L AT++ Sbjct: 1524 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1569 Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 +L+ + L+G+ ++ + ++Q +K + + T + + AA + Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629 Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079 G+ K ++ S + +E Q R + + D L + + +++ + T+ Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1684 Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138 +KS A + + D + + + + K+++ +L + L G LQ + Sbjct: 1685 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1739 Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198 EA I L E ++ + SD Q + LA E ++ Sbjct: 1740 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1789 Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 E+ +QQLE Q N +L S++H ++ + ++ S + + +++ + Sbjct: 1790 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1835 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 Q++ + + + K +E+L + + +AE ++EQ + +++L++ Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895 Query: 1319 GKSVGVEMNTQNELMER 1335 + +N ++R Sbjct: 1896 AEEESQRINANRRKLQR 1912 Score = 72.0 bits (175), Expect = 5e-12 Identities = 102/458 (22%), Positives = 195/458 (42%), Gaps = 85/458 (18%) Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140 LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E Sbjct: 1499 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1549 Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199 E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L Sbjct: 1550 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605 Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251 E + E + AL K +L +LK ++K +E I+ L++ ++QM Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665 Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304 + A R+E A E++K+ S E + L+EDL ER Sbjct: 1666 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715 Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343 E+A E +SL A+Q L+++ ++EE + E+ Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775 Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385 LS A R QK ++ E +G+ +++ ++ EA A L Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835 Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+ Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895 Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 E +N + ++ R +ESN+ + + +K Sbjct: 1896 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALK 1932 Score = 62.8 bits (151), Expect = 3e-09 Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%) Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842 E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++ Sbjct: 915 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971 Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 ++ +L K++ EA++ K L+D + + + + L + + E + N Sbjct: 972 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1022 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 A E + +NL + +++S + ++ +KSR L K R L + Sbjct: 1023 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1071 Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021 + QI +LQ ++ E K + ++L A A ++ L Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1117 Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081 K I+ D + D D +R+ +E D L + K ED L T+ Sbjct: 1118 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174 Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137 L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+ Sbjct: 1175 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233 Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181 Q E L G + Q+ K K SDGE +V ++ Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293 Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235 + +L + I ++ + +L QL++ + LQ+E + + +++ L+ + Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353 Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293 L + + Q R +S Q+ D S++ + E L + Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1406 Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349 E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466 Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409 S+ +A D++ E E + S +E E + Sbjct: 1467 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1506 Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469 EE +TN+ L+ ++E S + +H L K +AL + + Sbjct: 1507 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1551 Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529 ++ D+L+ + K ++Q + + + ++ EK R Q+ + E Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1609 Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563 + +++E K R + KL L+ +EL+A Sbjct: 1610 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1640 Score = 60.1 bits (144), Expect = 2e-08 Identities = 222/1172 (18%), Positives = 446/1172 (38%), Gaps = 168/1172 (14%) Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503 E+++ + +E +K E + K+ +L EQ LTE N LQ E E Sbjct: 859 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913 Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563 + L AA+ EL E ++ + + ++ KK + +L + L++E+ Sbjct: 914 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972 Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618 L ++ + I L+ E+ + +L ++ RK LEE+IS++ Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1025 Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678 EE++ +L + + S+ E R + E S++EL+K L ++L D + I Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1078 Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738 DL E LA KE+E + L D+ Q++N + K Sbjct: 1079 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1119 Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798 +R E ISD L+E A EK L + LK Sbjct: 1120 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1160 Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857 E L T+QE+ + T K + H Q + H + QL Sbjct: 1161 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219 Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913 + K L D + QT+ E DL LR +A +E +K A E + + Sbjct: 1220 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277 Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962 G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++ Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1332 Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010 + Q L + +L++ + L +L + ME + ++ + LN Q Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389 Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062 V A + QK I+ + + +K D+ + E+D + D+ L Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449 Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109 S E + + Y + + A+ T E++ E Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509 Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164 E LK ++ DL + + + +L+K + E + + E +D L ++ Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569 Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224 E+ +L + ++ + ++ A + + L++QL E E +L+ E+ Sbjct: 1570 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623 Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272 + L+ +DL ++ +Q+Q ++ + + + + + Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683 Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331 K+ E L D AE ++Q + + EL E+L ++ E Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743 Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389 + ++EE+ L E E A+SD + + ++ NE TE+++ N Sbjct: 1744 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1791 Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449 ++ L +E+R+ +E ++K+ K + + ++ Q + E ++ Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849 Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509 S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R+ Sbjct: 1850 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904 Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541 + +R + + G+E++ ++ +++ Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1936 Score = 57.0 bits (136), Expect = 2e-07 Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%) Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109 ET +++ E+++ + L++ + L+ + +++ E + +L+ + Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604 Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163 + + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ + Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1663 Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222 ++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L Sbjct: 1664 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720 Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263 EEL SL + AL + L+EE+ M + V +L Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780 Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302 A R ++ E+ Q+E Q KE S E +I LEE + ++ Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840 Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ + Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899 Score = 47.8 bits (112), Expect = 1e-04 Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%) Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153 DQ+ + S E + L+++I DL T L E +N KH + L E + Sbjct: 999 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056 Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213 + L K K +G+ F H +I + +++ E LK QL ++E +L Sbjct: 1057 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1099 Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261 Q ++ +N K R+L D + + Q R+L + + +K Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159 Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310 + S Q + + KA +E ++ + V E Q+ EL E Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1217 Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357 +LE+ K ++ + +E+ D + ++ E+ Sbjct: 1218 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273 Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417 SD E + + K NE E + M+N ++ ++ +++ +L +L+++ + Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1328 Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477 +L ++ RQ + + L L E+ + + ++ + I+ S K+K Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388 Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531 D L E R +E+L ++Y ++L+K + ++ L+ ++ Q Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448 Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566 +S ++++ + QLL++ + R E +A EK Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488 Score = 39.3 bits (90), Expect = 0.035 Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%) Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341 EE+ D E Q+ N+ EL +K +L + ++ + EL EE + Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918 Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401 E E L + E + R Q+ E +K + + L E ++E Sbjct: 919 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 968 Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461 R++L+ T E K+LE + + ++ L+ E L ++ Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1017 Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519 L L + +K K KL+ LE ++ ++E E+L++ EG + H Sbjct: 1018 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076 Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579 Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1129 Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639 ++ D DS +A K+ + L G + ++L + + ST L Sbjct: 1130 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1181 Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695 + + + +EA ++++ +Q L E Q + A ++ + T A Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241 Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737 L+ + + AK +E ++L+ L + S E + L+ + Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301 Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774 + E + + KL K + +LQ+T +LLQ RQ+ Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 110 bits (276), Expect = 1e-23 Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V Sbjct: 858 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 911 Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144 + + K+EL+E +QL + K + + EA ++Q Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971 Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181 K A K++++ED L+K LLE+ D+T AE L+ Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031 Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236 +E +RL+ E K L ++K+ EGD + + + I ELK+ L KE Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091 Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294 +Q N EL G + +E+ + E AA+ + +K++ E ++A Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1150 Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354 L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207 Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414 L + Q ++F+ ++ A L T EN L ++ + Q +++ + Sbjct: 1208 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253 Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467 +++LE ++E + S G+ +L ++V KL+NEV NE E K + S Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313 Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527 S++ QE + + + N L Q E++ Q + + A ++LE L + Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1372 Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582 S KK+ D+ ++ L++ + + +++L +++ + + L+ Sbjct: 1373 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R Sbjct: 1421 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473 Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693 + E +E L + + + ++ +EL N+ LK + DL S G + Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533 Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721 R T+ E+ E+ ED ++ ED ++ Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKL 1563 Score = 96.7 bits (239), Expect = 2e-19 Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%) Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96 L N++EE +K+ E+ I+EL K+E +L E+++++ G Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1064 Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156 ++ +L+ ++ LK +L ++E+ L A ++ + +++++E Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124 Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204 EDL ++R L +++ A + ELE T T++ LR + E +++ +KK Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184 Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 HE + A ++E +E+ K + + + Q L++E + +A Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1237 Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315 GELR L A +E +EH+K++ E ++Q L+ + ER A K Sbjct: 1238 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1284 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375 ++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1340 Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435 E +L+ Q + L R I + +LSD +++ + +E K + Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL + Sbjct: 1401 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 E I+ K + ++ KE K S L + Sbjct: 1460 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1494 Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615 L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+ Sbjct: 1495 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544 Query: 616 RRREEE 621 + + EE Sbjct: 1545 KTQLEE 1550 Score = 92.8 bits (229), Expect = 3e-18 Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%) Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134 L++ EE MQ E E K ELK E+E +L E + LL + +A E Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194 AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+ Sbjct: 904 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 942 Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254 +E KKM + L + L+E++ ++L+L + EA I+ L++E M + + Sbjct: 943 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997 Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314 S KER EERI L +L E+E + K Sbjct: 998 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030 Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374 K + I L + LK +EK +EL KL + E + Q Q + + L+ Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1086 Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433 K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K + Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1138 Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490 RDL E+E L+ E +E+ S ++ + +++V K L E T + Sbjct: 1139 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191 Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540 +Q+ +K + +++ + A +L+ + L E + + Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251 Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595 K+KK + +EL + L +D ++ LQ E+ + + + E Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1305 Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642 +DV S Q+ ++ L+E+ +++R+ EEE SL + Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365 Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702 + + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1419 Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757 ++ ++ DD + L +Q +++ +L K K L E IS Sbjct: 1420 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469 Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811 + D A A +E ++L L +A LE +LK E L+ + E Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529 Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871 E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+ Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1583 Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897 Q L R HE E +E+ Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDER 1609 Score = 79.3 bits (194), Expect = 3e-14 Identities = 130/609 (21%), Positives = 255/609 (41%), Gaps = 81/609 (13%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 ++D + + E ++ N+ ++ LEE + + + L+ + +L +L + Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375 Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179 ++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+ Sbjct: 1376 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1430 Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224 + ++ L LE K + ++ E + DE+DR L Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490 Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284 L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + + Sbjct: 1491 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547 Query: 285 RNSFEERIQALEE-DLR----------EKEREI-ATEKKNSLKRDKAIQGLTMALKSKEK 332 E+ +QA E+ LR + ER++ A +++N KR + L L E Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR----RQLQRQLHEYET 1603 Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392 ++E+ + +AA K L+ + Q + E A+ L A ++ + + Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--DFQREL 1661 Query: 393 ENHRLRR-----SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL- 446 E+ R R + K+ ++ L+ + +L++DL A R + + D +L E+ Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721 Query: 447 --RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKF------NE 498 RN + + ++ +E R L E ++ N E + + ++T Q + L + + Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781 Query: 499 KDLEVIQQNCYLMAAEDLELRS-----EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553 K+ QQ + ++ ELRS EG + K S TI + E K + E++ Sbjct: 1782 KNESARQQ----LERQNKELRSKLHEMEGAVKSKFKS-------TIAALEAKIAQLEEQV 1830 Query: 554 IQVLKKEQDIYTHLVKSLQESDS-----INNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608 Q +++Q KSL++ D + ++ E ++Q E+ + L++ L Sbjct: 1831 EQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886 Query: 609 EEQISEIRR 617 EE E +R Sbjct: 1887 EEAEEESQR 1895 Score = 79.0 bits (193), Expect = 4e-14 Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%) Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315 +++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+ Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 893 Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367 + + + L +K++++EE+ E+E + LQ + + Q Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953 Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424 D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013 Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474 E+ + + L+N+ E + +E+ R K E + + L + +KL Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1072 Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532 Q Q+ + + +++ L D E+ Q+N L +L EG I++ + Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1126 Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591 + +K +KQ D E ++ LK T L +L + + L+A+ ++ L+ Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1180 Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641 K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N Sbjct: 1181 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233 Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682 + +VEH + +EL+ K SD + EL L+ + ++ Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293 Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729 M + G +LA + T+ L +E + + ++E N L DQ L Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1352 Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783 + E ++L + N L ++ K+ D A LEEG I L + E Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1410 Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841 KA LE + L+ + L+ L Q VS +L+ K K + E + N Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1463 Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 SK DE + EA+ + E + L A + + + +L E T + + + + Sbjct: 1464 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1516 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 S + +N+H + + AL T E K++L L L AT++ Sbjct: 1517 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1562 Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020 +L+ + L+G+ ++ + ++Q +K + + T + + AA + Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622 Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079 G+ K ++ S + +E Q R + + D L + + +++ + T+ Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1677 Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138 +KS A + + D + + + + K+++ +L + L G LQ + Sbjct: 1678 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1732 Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198 EA I L E ++ + SD Q + LA E ++ Sbjct: 1733 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1782 Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258 E+ +QQLE Q N +L S++H ++ + ++ S + + +++ + Sbjct: 1783 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1828 Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 Q++ + + + K +E+L + + +AE ++EQ + +++L++ Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888 Query: 1319 GKSVGVEMNTQNELMER 1335 + +N ++R Sbjct: 1889 AEEESQRINANRRKLQR 1905 Score = 72.0 bits (175), Expect = 5e-12 Identities = 102/458 (22%), Positives = 195/458 (42%), Gaps = 85/458 (18%) Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140 LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E Sbjct: 1492 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1542 Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199 E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L Sbjct: 1543 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598 Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251 E + E + AL K +L +LK ++K +E I+ L++ ++QM Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658 Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304 + A R+E A E++K+ S E + L+EDL ER Sbjct: 1659 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708 Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343 E+A E +SL A+Q L+++ ++EE + E+ Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768 Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385 LS A R QK ++ E +G+ +++ ++ EA A L Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828 Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+ Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888 Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 E +N + ++ R +ESN+ + + +K Sbjct: 1889 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALK 1925 Score = 62.8 bits (151), Expect = 3e-09 Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%) Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842 E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++ Sbjct: 908 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964 Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901 ++ +L K++ EA++ K L+D + + + + L + + E + N Sbjct: 965 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1015 Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961 A E + +NL + +++S + ++ +KSR L K R L + Sbjct: 1016 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1064 Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021 + QI +LQ ++ E K + ++L A A ++ L Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1110 Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081 K I+ D + D D +R+ +E D L + K ED L T+ Sbjct: 1111 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167 Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137 L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+ Sbjct: 1168 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226 Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181 Q E L G + Q+ K K SDGE +V ++ Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286 Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235 + +L + I ++ + +L QL++ + LQ+E + + +++ L+ + Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346 Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293 L + + Q R +S Q+ D S++ + E L + Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1399 Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349 E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459 Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409 S+ +A D++ E E + S +E E + Sbjct: 1460 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1499 Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469 EE +TN+ L+ ++E S + +H L K +AL + + Sbjct: 1500 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1544 Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529 ++ D+L+ + K ++Q + + + ++ EK R Q+ + E Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1602 Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563 + +++E K R + KL L+ +EL+A Sbjct: 1603 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1633 Score = 60.1 bits (144), Expect = 2e-08 Identities = 222/1172 (18%), Positives = 446/1172 (38%), Gaps = 168/1172 (14%) Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503 E+++ + +E +K E + K+ +L EQ LTE N LQ E E Sbjct: 852 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906 Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563 + L AA+ EL E ++ + + ++ KK + +L + L++E+ Sbjct: 907 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965 Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618 L ++ + I L+ E+ + +L ++ RK LEE+IS++ Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1018 Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678 EE++ +L + + S+ E R + E S++EL+K L ++L D + I Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1071 Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738 DL E LA KE+E + L D+ Q++N + K Sbjct: 1072 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1112 Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798 +R E ISD L+E A EK L + LK Sbjct: 1113 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1153 Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857 E L T+QE+ + T K + H Q + H + QL Sbjct: 1154 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212 Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913 + K L D + QT+ E DL LR +A +E +K A E + + Sbjct: 1213 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270 Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962 G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++ Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1325 Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010 + Q L + +L++ + L +L + ME + ++ + LN Q Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382 Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062 V A + QK I+ + + +K D+ + E+D + D+ L Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442 Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109 S E + + Y + + A+ T E++ E Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502 Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164 E LK ++ DL + + + +L+K + E + + E +D L ++ Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562 Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224 E+ +L + ++ + ++ A + + L++QL E E +L+ E+ Sbjct: 1563 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616 Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272 + L+ +DL ++ +Q+Q ++ + + + + + Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676 Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331 K+ E L D AE ++Q + + EL E+L ++ E Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736 Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389 + ++EE+ L E E A+SD + + ++ NE TE+++ N Sbjct: 1737 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1784 Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449 ++ L +E+R+ +E ++K+ K + + ++ Q + E ++ Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842 Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509 S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R+ Sbjct: 1843 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897 Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541 + +R + + G+E++ ++ +++ Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1929 Score = 57.0 bits (136), Expect = 2e-07 Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%) Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109 ET +++ E+++ + L++ + L+ + +++ E + +L+ + Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597 Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163 + + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ + Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1656 Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222 ++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L Sbjct: 1657 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713 Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263 EEL SL + AL + L+EE+ M + V +L Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773 Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302 A R ++ E+ Q+E Q KE S E +I LEE + ++ Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833 Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ + Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892 Score = 47.8 bits (112), Expect = 1e-04 Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%) Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153 DQ+ + S E + L+++I DL T L E +N KH + L E + Sbjct: 992 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049 Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213 + L K K +G+ F H +I + +++ E LK QL ++E +L Sbjct: 1050 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1092 Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261 Q ++ +N K R+L D + + Q R+L + + +K Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152 Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310 + S Q + + KA +E ++ + V E Q+ EL E Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1210 Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357 +LE+ K ++ + +E+ D + ++ E+ Sbjct: 1211 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266 Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417 SD E + + K NE E + M+N ++ ++ +++ +L +L+++ + Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1321 Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477 +L ++ RQ + + L L E+ + + ++ + I+ S K+K Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381 Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531 D L E R +E+L ++Y ++L+K + ++ L+ ++ Q Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441 Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566 +S ++++ + QLL++ + R E +A EK Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481 Score = 39.3 bits (90), Expect = 0.035 Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%) Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341 EE+ D E Q+ N+ EL +K +L + ++ + EL EE + Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911 Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401 E E L + E + R Q+ E +K + + L E ++E Sbjct: 912 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 961 Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461 R++L+ T E K+LE + + ++ L+ E L ++ Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1010 Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519 L L + +K K KL+ LE ++ ++E E+L++ EG + H Sbjct: 1011 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069 Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579 Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1122 Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639 ++ D DS +A K+ + L G + ++L + + ST L Sbjct: 1123 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1174 Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695 + + + +EA ++++ +Q L E Q + A ++ + T A Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234 Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737 L+ + + AK +E ++L+ L + S E + L+ + Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294 Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774 + E + + KL K + +LQ+T +LLQ RQ+ Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331 >gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] Length = 1684 Score = 107 bits (266), Expect = 1e-22 Identities = 314/1646 (19%), Positives = 623/1646 (37%), Gaps = 263/1646 (15%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL------ 117 E Q LKKEN +K + E + + + +++I E+E+LK EL Sbjct: 89 EQQCLSLKKENIKMKQEV----EDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144 Query: 118 --QEREQLLIKASKAVESLAEAGGS-EIQRVKEDARKKVQQ----VEDLLTKRILLLEKD 170 +++ L + +A+ + E + Q ED KK+Q+ + ++IL L+K Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204 Query: 171 VTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAM-ALVLDEKDRLIEELKLS 229 + A E ++ T+ + + + + + E L + A+ +E L+ +++ S Sbjct: 205 LDATTDEKKETV--TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262 Query: 230 LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-----KE 284 K EA I L E K + E S ++ E + T A ++Q + Sbjct: 263 AKEHEAEINKLNELKENLVKQCE-ASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 321 Query: 285 RNSF-----EERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNS 339 N+F E+++ LE+ L+E E ++S+ +D+ + LK L Sbjct: 322 ENTFVEQVVNEKVKHLEDTLKE------LESQHSILKDEVTYMNNLKLK--------LEM 367 Query: 340 EIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399 + + + F RE L+ + E+ + ++ A L Q +++R + Sbjct: 368 DAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQ 427 Query: 400 SIKKITQE---------LSDLQQER-------ERLEKDLEEAHREKSKGDCTIRDLRNEV 443 S+K+ Q+ LSD ++E+ + L++ E +EK + LR + Sbjct: 428 SLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM 487 Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503 E L+ E+ E + ++S+ + +H +Q ++ + +KD LL+ N E Sbjct: 488 EILQTELGESAGKISQEFESMKQQQASDVHELQQKLR---TAFTEKDALLETVNRLQGE- 543 Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI-FSKEKKQSSDYEELIQVLKKEQD 562 N L++ ++L E I + Q+ G + S+ + E I L +E+D Sbjct: 544 ---NEKLLSQQELVPELENTIK---NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD 597 Query: 563 IYTHLVK-SLQESDSINN-LQAELNKIFALRKQLEQDVLSYQNLRKT-------LEEQIS 613 + + +K S +E D+ + + E I L K++EQ + L + LEE + Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK 657 Query: 614 EIRRREEE------SFSLYSDQTSYLSI----CLEENNRFQVEH----------FSQEE- 652 E + +++ + S+ LS EENN+ E SQ+E Sbjct: 658 EKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED 717 Query: 653 --LKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGF----QGNGFPDRLASTEQTELLAS 706 LK+ ++ L + ++ + + +L K + + Q GF + S E+ Sbjct: 718 VILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS----EVSED 773 Query: 707 KEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPG 766 E++D + + LQ E + +++ C + R + K+ + + Sbjct: 774 SEEKDVVNV-------------LQAVGESLAKINEEKCNLAFQR--DEKVLELEKEIK-- 816 Query: 767 CLEEGAFI------NLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820 CL+E + + +LL EK L R +L ++ E Q L E + + E Sbjct: 817 CLQEESVVQCEELKSLLRDYEQEKVLL----RKELEEIQSEKEALQSDLLEMKNANEKTR 872 Query: 821 GKTEKTPKQKGEL--------VHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDAS 872 + + Q E+ +H + F K H+ LK E + ++ + LKD+ Sbjct: 873 LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSL 932 Query: 873 VQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGV---------------PG 917 ++ + + D L E EEK N + + E ++ + Sbjct: 933 AKSPSVKNDPLSSVKEL-----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987 Query: 918 WQAALLSLPGI-TNREAKKSRLPILIKPSRSLGNMY--------RLPATQEVVTQLQSQI 968 Q L + + ++ + + LI+ + S N+ +L +E + +I Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047 Query: 969 LELQGELK----EFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQ 1024 +L +L+ + +T N L E + + +L Q Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ-------------- 1093 Query: 1025 KGIKTTSSVWRDKEMDSDQ-QRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLS 1083 + DKE+++++ Q+ +I ++L L + + L T L Sbjct: 1094 -----RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148 Query: 1084 SK-SQPSAKVSVMGTDQSESINTSNETEYLK-QKIHDLETELEGYQNFIFQLQKHSQCSE 1141 K +Q + +++ D + N+ K KI DLE E++ Q QK E Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK------IQKQKQETLQE 1202 Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE- 1200 I ++ + ++ +K K VK K L D +L+ Sbjct: 1203 EITSLQSSVQQYEEKNTKIKQ---------------LLVKTKKELADSKQAETDHLILQA 1247 Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260 +LK +LE + +++ + ++ SE H + + + +L Q R +LQ + Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307 Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASD--VDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318 ++ + + ++ L Q + + EG +++ L+++L K+ L Sbjct: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KIKLQ 1366 Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQH--LLPE--SPEPSASHALSDYETSEKSFFS-RD 1373 +++N + E D L +H +L E S E L ++ S Sbjct: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHT 1426 Query: 1374 QKQDNETEKTSVMVNSFS---QDLLMEHIQEIRTLRKRLEE----------------SIK 1414 Q T + V+ NSF + L EH + + TL+++L + + Sbjct: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVS 1486 Query: 1415 TNEKLRKQLERQGSE--FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRD 1472 + + L+ ER+ ++ + T G + ++ T + Q+L +L Sbjct: 1487 SQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL------ 1540 Query: 1473 KQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE 1532 KL L + E L ++ +S + + L E E N L+++++ E Sbjct: 1541 -NSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSE 1599 Query: 1533 LSRV---QEEVKLRQQLLSQNDKLLQ 1555 + R+ QE K L + LLQ Sbjct: 1600 IRRLERNQEREKSAANLEYLKNVLLQ 1625 Score = 99.8 bits (247), Expect = 2e-20 Identities = 295/1523 (19%), Positives = 591/1523 (38%), Gaps = 261/1523 (17%) Query: 195 LESKLSEMKKMH----EGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACP 250 LE ++ E++ GD+ AL + D L+ L+ E QCL +K + Sbjct: 51 LEKEIEELRSKPVTEGTGDIIKALT-ERLDALL------LEKAETEQQCLSLKKENIKMK 103 Query: 251 DENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEK 310 E S G + +E E + + + KE + + + A+ E + + + Sbjct: 104 QEVEDSVTKMG-------DAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQL 156 Query: 311 KNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQK---AQTQEFQ--- 364 + ++ + + E V++L EIEK+ F + LQK A T E + Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216 Query: 365 ---------GSEDYETALSGKEALSAALRSQNLTKSTE-NHRLRRSIKKITQELSDLQQE 414 S+ Y+ ++ + L++ + + E ++ S K+ E++ L + Sbjct: 217 TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNEL 276 Query: 415 RERLEKDLEEAHRE-KSKGDCTIRDLR---------NEVEKLRNEVNEREKAMENRYKSL 464 +E L K E + + + K +C + +LR N++ + + N + + N Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336 Query: 465 LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR----- 519 L ++ K+L +Q ++K N + L E D + I+ + EDLE + Sbjct: 337 LEDTLKELESQHSILKDEVTYMNNLKLKL----EMDAQHIKDE-FFHEREDLEFKINELL 391 Query: 520 ----SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESD 575 +G + EK S+ +K ++ + + + L + +KE S E + Sbjct: 392 LAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKE 451 Query: 576 SIN---NLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632 + +Q + L+++ ++ +L+Y++LR+ +E +E+ ES S + Sbjct: 452 KLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL----GESAGKISQEFES 507 Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692 + +++ V +L Q ++ +T+ L +T+ L G Sbjct: 508 M----------------KQQQASDVHELQQKLRTAFTEKDALLETVNRL-------QGEN 544 Query: 693 DRLASTEQTELLASKEDEDTIK-IGEDDEINFLSDQHLQQSNEIMKDL-----SKGGCKN 746 ++L S Q EL+ E E+TIK + E + + LS L Q + ++K+L S K+ Sbjct: 545 EKLLS--QQELV--PELENTIKNLQEKNGVYLLS---LSQRDTMLKELEGKINSLTEEKD 597 Query: 747 GYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806 ++ ++ + D H EE + L +K ++ +L + V EL G Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILEL-----GKKVEQTIQYNSELEQKVNELTGG- 651 Query: 807 LFLTEQEVSGEHLDGKTEKTPKQKGELVH------------FVQTNSFSKPHDELKLSCE 854 L E + D K EK Q L + + N S +L E Sbjct: 652 --LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709 Query: 855 AQLVKAGEV---PKVGLKDASVQTVATEGDLLR--FKHEATREAWEE-------KPINTA 902 L + +V + + +Q + E D L ++E ++ + + K + + Sbjct: 710 VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSE 769 Query: 903 LSAEHRPENLHGVPGWQAALLSLPGIT--------NREAKKSRLPILIKPSRSLGNMYRL 954 +S + +++ V QA SL I R+ K L IK + ++ + Sbjct: 770 VSEDSEEKDVVNV--LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE-ESVVQC 826 Query: 955 PATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVG 1014 + ++ + + + L+ EL+E ++ + L L+ + E ++ LL V Sbjct: 827 EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS 886 Query: 1015 AAYQDS----PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPE 1070 S E+ IK ++ E + R E+ I D LA PS K +P Sbjct: 887 QTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL---ILLKDSLAKSPSVKNDPL 943 Query: 1071 DVLSP-----TSVATYLSSKSQPSAKVSVMGTDQSESINTS-NETEYLKQKIHDLETE-- 1122 + ++ K + K+ ++ + +++S ET+ +K+++ L +E Sbjct: 944 SSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003 Query: 1123 ------------LEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKN-------- 1162 E Y+N + + +K S+ + E + L++ Sbjct: 1004 QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063 Query: 1163 -GSDGEEM--TFSSLHQVRYVKHVKILG-PLAPEMIDSRV-LENL--KQQLEEQEYKLQK 1215 SD E++ +L + V+IL A M+D + E L +Q+++E + + Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123 Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275 + L +QL E LQ ++L LV+ A++ +L +I D + Q + Sbjct: 1124 LEELQVQLQKEKKQLQKTMQEL------ELVKKDAQQTTLMNMEIADYERLMKELNQKLT 1177 Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER 1335 E+L Q + E QE E+ + +++ Sbjct: 1178 NKNNKIEDLEQEIKIQKQKQETLQE------------------------EITSLQSSVQQ 1213 Query: 1336 IEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLL 1395 EE N + LL ++ + L+D + +E E E + V + L Sbjct: 1214 YEEKNTKIKQLLVKTKK-----ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQL- 1267 Query: 1396 MEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI---FASGSELHSSLTSE- 1451 EI + + ++ E +KT+ +Q +R S + Q T++ + +++TSE Sbjct: 1268 ----AEITSEKHKIHEHLKTS---AEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320 Query: 1452 ------IHFLRKQ--NQALNAMLIKGSRDKQKENDKLRESLSRK-----------TVSLE 1492 +H + KQ N++++ +G++ +++ + L + L K L+ Sbjct: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380 Query: 1493 HLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS--GQELSRVQEEVKLRQQLLSQN 1550 LQ E+ ++ E + ++ +E KE ++E CS + + E + QL SQN Sbjct: 1381 TLQSEHDTLLERHNKMLQETVSKEAE----LREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436 Query: 1551 DKLLQSLRVELKAYEKLDEEHRR 1573 + L S R +++ L EEHR+ Sbjct: 1437 EVLRNSFRDQVR---HLQEEHRK 1456 Score = 98.2 bits (243), Expect = 6e-20 Identities = 270/1336 (20%), Positives = 535/1336 (40%), Gaps = 196/1336 (14%) Query: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR 384 M ++ + + EL EIE+L + K T+ G+ D AL+ E L A L Sbjct: 39 MLIQKAKSRCTELEKEIEELRS----------KPVTE---GTGDIIKALT--ERLDALLL 83 Query: 385 SQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE 444 + T+ + L++ K+ QE+ D + K+LE++H K I +L+NE+ Sbjct: 84 EKAETEQ-QCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK---EIENLKNELM 139 Query: 445 KLRNEVNEREKAMENRYKSL------LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498 +R++ +E + ++ + + LSE K +N E +K L E + ++ E Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEK----IRPGFE 195 Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLK 558 + + +Q+ E E ++ + +SQ +K +S EEL+Q+ Sbjct: 196 EQILYLQKQLDATTDEKKETVTQLQNIIEANSQH---------YQKNINSLQEELLQLKA 246 Query: 559 KEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQL-EQDVLSYQNLRKTLEEQISEIRR 617 Q+ L+ ++ S + +AE+NK+ L++ L +Q S +N++K E ++ +R+ Sbjct: 247 IHQEEVKELMCQIEASAKEH--EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRK 304 Query: 618 REEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKT 677 + + SI L+EN F ++ + +KV L +KEL + + LK Sbjct: 305 ATSNA----NQDNQICSILLQENT------FVEQVVNEKVKHLEDTLKELESQHSILKDE 354 Query: 678 I---------FDLSCMGFQGNGFPDRL-ASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727 + ++ + F +R + ELL +KE++ + E+ L+ Q Sbjct: 355 VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414 Query: 728 H---LQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEK 784 ++Q N ++ L + K E+ +SD + E L EK Sbjct: 415 FCYTVEQHNREVQSLKEQHQKE-ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEK 473 Query: 785 ATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVH--------- 835 +L + L+ + E+L +L + ++S E E +Q+ VH Sbjct: 474 QEAILNY--ESLREIMEILQTELGESAGKISQEF-----ESMKQQQASDVHELQQKLRTA 526 Query: 836 FVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQ--------TVATEGDLLRFKH 887 F + ++ + + L+ E L + VP++ ++Q +++ +L+ Sbjct: 527 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 586 Query: 888 EATREAWEEKP--INTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS 945 EEK IN ++ +N H ++ ++ IL Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH-----------------KKCEREERLIL---- 625 Query: 946 RSLGNMYRLPATQEVVTQLQSQILELQGELKEF---KTCNKQLHQKLILAEAVMEGRPTP 1002 LG ++ T + ++L+ ++ EL G L+E K N Q +KL++ V+ + Sbjct: 626 -ELGK--KVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL----SE 678 Query: 1003 DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASL 1062 DK +L+A+ V + Y+++ K S RD E+ Q+ + I + L Sbjct: 679 DKEVLSAE--VKSLYEENNKLSSEKKQLS---RDLEVFLSQKEDVILKEHITQLEKKLQL 733 Query: 1063 PSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETE 1122 +++ + L L K+Q + MG++ SE + L+ L Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793 Query: 1123 LEGYQNFIFQ-------LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLH 1175 E N FQ L+K +C + V C ++ S ++ + + L Sbjct: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQC-----EELKSLLRDYEQEKVLLRKELE 848 Query: 1176 QVRYVKHVKILGPLAPEMIDSRVLE----NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231 +++ K E + S +LE N K +LE Q +Q E+ SEIHN + Sbjct: 849 EIQSEK----------EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898 Query: 1232 NK-----FRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286 K +L P L Q + R+ + +KD + + +K EE ++ Sbjct: 899 EKCFIKEHENLKP----LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954 Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHL 1346 + +C E EK+ K+ L E+++ + + ++E+ + L Sbjct: 955 NLE-------------KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEE---LESL 998 Query: 1347 LPESPEPSAS-HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTL 1405 E + SAS L S K+ +KQ + + N+F + + + +++R Sbjct: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNF-EHRIEDLTRQLRNS 1057 Query: 1406 RKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM 1465 + E NE L ++E S I + + E+ + Q + Sbjct: 1058 TLQCETINSDNEDLLARIETLQSNAKLLEVQILEV-QRAKAMVDKELEAEKLQKE----Q 1112 Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER---LQKEGSEKERHNQQL 1522 IK E ++L+ L ++ L+ +E VK++ ++ + E ++ ER ++L Sbjct: 1113 KIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172 Query: 1523 IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPM 1582 Q++ ++ +++E+K+++Q + + SL+ ++ YE+ + + ++L K Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKK-- 1230 Query: 1583 ESDNSFDLFDSSQAVT 1598 +L DS QA T Sbjct: 1231 ------ELADSKQAET 1240 Score = 83.6 bits (205), Expect = 2e-15 Identities = 297/1476 (20%), Positives = 562/1476 (38%), Gaps = 230/1476 (15%) Query: 60 MKDFENQITELKKENF---NLKLRIYFLEERMQQEFHGPTEHI-YKTNIELKVE------ 109 +K+ E+Q + LK E NLKL++ + ++ EF E + +K N L + Sbjct: 341 LKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400 Query: 110 VESLKRELQEREQLLI----KASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRIL 165 +E LK EL + + ++ V+SL E EI + E ++ + L I Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460 Query: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM--KKMHEGDLAMALVLDEKDRLI 223 L++ Q E ++A E+ + + L+++L E K E + + L Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520 Query: 224 EELKLSLKSKEALIQC---LKEEKSQMACPDENVSSGE-----------LRGLCAAPREE 269 ++L+ + K+AL++ L+ E ++ E V E + L + R+ Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580 Query: 270 KERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKS 329 +E E +E++ F +++ E++ ++ E++ L+ K ++ Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640 Query: 330 KEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT 389 E+KV EL +E+ + + L+K Q SED KE LSA Sbjct: 641 LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED-------KEVLSA-------- 685 Query: 390 KSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK---- 445 +K + +E + L E+++L +DLE +K D +++ ++EK Sbjct: 686 ----------EVKSLYEENNKLSSEKKQLSRDLEVFLSQKE--DVILKEHITQLEKKLQL 733 Query: 446 LRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDV--LLQKFNEKDLEV 503 + E + K +EN L + +++ ++E + +KDV +LQ E ++ Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793 Query: 504 IQQNCYLMAAED---LELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560 ++ C L D LEL E KC ++ S + K DYE+ +L+KE Sbjct: 794 NEEKCNLAFQRDEKVLELEKE----IKCLQEE---SVVQCEELKSLLRDYEQEKVLLRKE 846 Query: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEE-----QISEI 615 L+E S +A + + ++ E+ L QNL +EE SEI Sbjct: 847 ----------LEEIQS--EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI 894 Query: 616 RRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVS---DLIQLVKELYTDNQ 672 +E+ F + L E +R ++ L K S D + VKEL + Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954 Query: 673 HLKKTIFDLSCMGFQGNGFPDRLASTE-QTELLASKEDEDTIKIGEDDEINFLSDQHLQQ 731 +L+K C + +L + + + EL +S+++ T+K +E+ L + Q Sbjct: 955 NLEK-----ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK----EELESLRSEK-DQ 1004 Query: 732 SNEIMKDLSKG--GCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNE--KATL 787 + M+DL +G KN L + E + D E +L L N + Sbjct: 1005 LSASMRDLIQGAESYKNLLLEY-EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063 Query: 788 LLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHD 847 + DLL + L L Q + + +K + + K Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAE-------------KLQK 1110 Query: 848 ELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEH 907 E K+ A V E +V L+ Q T +L K +A + T ++ E Sbjct: 1111 EQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQ--------TTLMNME- 1161 Query: 908 RPENLHGVPGWQAALLSL-PGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQS 966 + ++ + L +TN+ K L IK + + QE +T LQS Sbjct: 1162 -------IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ-----KQETLQEEITSLQS 1209 Query: 967 QILELQGELKEFKTC----------NKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAA 1016 + + + + + K +KQ ++ +A ++G + + A Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269 Query: 1017 YQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPT 1076 + TS+ + + + QQR + E C+ + + T Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE------------CRAAKAEQATVT 1317 Query: 1077 S------VATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQN-- 1128 S V + K Q + +S Q+E+ E E+L+ I L+ +L+ QN Sbjct: 1318 SEFESYKVRVHNVLKQQKNKSMS-----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372 Query: 1129 --FIFQLQ----KHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKH 1182 + +LQ +H E +L T + L + E M S +H Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS-------EH 1425 Query: 1183 VKILGPLAP--EMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPP 1240 + + L E++ + + ++ EE ++ Q ++ +++ L+N+ P Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE------P 1479 Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQE 1300 S V SQ +L+ ++ D + M+T+ + E ++ +D E Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTD------LPLLDMHTVTREEGEGMETTDT---------E 1524 Query: 1301 QLNQCAELLEKLEKLFLNGKSVGVEMN------TQNELMERIEEDNLTYQHLLPESPEPS 1354 ++ + + LE+L LN +E T+ EL++++ + HL E Sbjct: 1525 SVSSASTYTQSLEQL-LNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETE 1583 Query: 1355 ASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIK 1414 A++A+ + R +++ E EK++ + LL + + R+RL I Sbjct: 1584 ATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVIN 1643 Query: 1415 TNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450 T +L S +G + A G E ++S +S Sbjct: 1644 TMLQL--------SPEEKGKLAAVAQGEEENASRSS 1671 Score = 65.9 bits (159), Expect = 4e-10 Identities = 116/573 (20%), Positives = 233/573 (40%), Gaps = 94/573 (16%) Query: 55 TRARNMKDFENQITELK--KENFNLKLRIYFLEERMQQEFHGPT-EHIYKTNIELKVEVE 111 T N K E QI E++ K + +L L++ + + H T + + ++L+ E + Sbjct: 1077 TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136 Query: 112 SLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKV----QQVEDL------LT 161 L++ +QE E L+K +L ++ +R+ ++ +K+ ++EDL Sbjct: 1137 QLQKTMQELE--LVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194 Query: 162 KRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDR 221 ++ L++++T+ Q+ +++ K L ++ + +L++ K+ E D Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA------------ETDH 1242 Query: 222 LIEELKLSLKSK-EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQME 280 LI L+ SLK + EA Q ++ K Q+A + + + + + + Sbjct: 1243 LI--LQASLKGELEASQQQVEVYKIQLA-------------EITSEKHKIHEHLKTSAEQ 1287 Query: 281 HQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSK---EKKVEEL 337 HQ+ +++++R+ AL+E+ R + E AT + + K+K + + E Sbjct: 1288 HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA 1347 Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRL 397 E E L + + LQ +Q + +T S + L L Sbjct: 1348 KQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL-----------------L 1390 Query: 398 RRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAM 457 R K + + +S + RE+L E KS+ T+ L ++ E LRN ++ + + Sbjct: 1391 ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450 Query: 458 ENRYKSLLSESNKKLHNQE-QVIKHLTESTNQKDVL-------LQKFNEKDLEVIQQNCY 509 + ++ + ++L E Q+ + E T + V L++ DL ++ + Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510 Query: 510 L------MAAEDLELRS---------EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554 M D E S E L+ + +PP F+K EEL+ Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK--------EELV 1562 Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKI 587 Q L HL L+E+++ N + E K+ Sbjct: 1563 QKLSSTTKSADHLNGLLRETEATNAILMEQIKL 1595 Score = 59.3 bits (142), Expect = 3e-08 Identities = 144/683 (21%), Positives = 264/683 (38%), Gaps = 91/683 (13%) Query: 1158 SKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEE-QEYKLQKE 1216 S K G +E+ S ++ V+ ++++K +A S NL++QLEE +L+ Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKN-ELMAVRSKYSEDKANLQKQLEEAMNTQLELS 167 Query: 1217 QNLNMQLFSE--IHNLQNKFRDLSPPRYDSLVQSQAR---ELSLQRQQIKDGHGICVISR 1271 + L Q SE + LQ + + P + ++ Q + +++ + I + Sbjct: 168 EQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANS 227 Query: 1272 QHMNTMIKAF-EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330 QH I + EELLQ + QE++ EL+ ++E + K E+N N Sbjct: 228 QHYQKNINSLQEELLQLKAIH-------QEEVK---ELMCQIEA---SAKEHEAEINKLN 274 Query: 1331 ELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF--FSRDQKQDNETEKTSVMVN 1388 EL E L + E S + YE ++ + + QDN+ + N Sbjct: 275 ELKEN-----------LVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQEN 323 Query: 1389 SFSQDLLMEHIQEIRTLRKRLEE---------SIKTNEKLRKQLERQG--SEFVQGSTSI 1437 +F + ++ E ++ + K LE + N KL+ +++ Q EF + Sbjct: 324 TFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL 383 Query: 1438 FASGSELH----------SSLTSEIHFLRKQN----QALNAMLIKGSRDKQKENDKLRES 1483 +EL L SE+ L KQ + N + QKE +L E+ Sbjct: 384 EFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNET 443 Query: 1484 -LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQL--IQEVRCS--GQELSRVQE 1538 LS L E +KE+ E LQ+E E + + L I E+ + G+ ++ + Sbjct: 444 FLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQ 503 Query: 1539 EVK-LRQQLLSQNDKLLQSLRVE-------LKAYEKLDEEHRRLRDGDKYPMESDNSFDL 1590 E + ++QQ S +L Q LR L+ +L E+ +L + E +N+ Sbjct: 504 EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563 Query: 1591 FDSSQAVTPKSVSETPPLSGN---DTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRH 1647 V S+S+ + +SL+ + + H + R Sbjct: 564 LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623 Query: 1648 VLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTA 1707 +L L K++ Q + +E++ + E + L K + L K + + Sbjct: 624 IL-------ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL 676 Query: 1708 KLTLEEAYRRLKLLW---------RVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEK 1758 E +K L+ + L D + L ++ +K +T+L KKL + Sbjct: 677 SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736 Query: 1759 KLQNTMKLLQLSKRQEKVIFDQL 1781 + N KLL+ + Q+ + QL Sbjct: 737 EQDNLNKLLENEQVQKLFVKTQL 759 >gi|31982906 cingulin-like 1 [Homo sapiens] Length = 1302 Score = 105 bits (261), Expect = 5e-22 Identities = 160/748 (21%), Positives = 304/748 (40%), Gaps = 87/748 (11%) Query: 43 LLPNVSEETVSPTRARNMKDFENQITELKKENFNLKL-RIYFLEERMQQEFHGPTEHIYK 101 L +EET +K+ + K NL +I L+ R G + Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS 605 Query: 102 TN-----IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156 T+ +E K ++ ELQ + QL +K + ++ E + ++ ++ +KV++ Sbjct: 606 TSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN 665 Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH-EGDLAMALV 215 L + LE+ + LE+ F + + + ++ +MH E D A Sbjct: 666 STLQQR----LEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721 Query: 216 LDEKDRLIEELKLSLKSKEALIQCL--KEEKSQMACPDENVSSGELRGLCAAPREEKERE 273 EK LIEEL L++K+ L L KEE+ + E EL L A +EE Sbjct: 722 DREKGALIEEL---LQAKQDLQDLLIAKEEQEDLLRKRER----ELTALKGALKEE---- 770 Query: 274 TEAAQMEHQKERNSFEERIQALEEDLRE--KEREIATEKKNSLKRDKAIQGLTMALKSKE 331 + E K + ++ +QAL E + E K E+ + N+ ++D+A G M +K + Sbjct: 771 VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA--GTEMRVKLLQ 828 Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED---YETALSGKEALSAALRSQNL 388 ++ E+L E+L A+ + ++ + E + E YE + E R + Sbjct: 829 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888 Query: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRN 448 + L ++ LS QE+++L + L+E +K + +R L+NE+E R Sbjct: 889 EAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ----LRRLKNEMENERW 944 Query: 449 EVNEREKAMENRYKSLLSES-NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507 + + + ++ ++ S L Q Q+ ++ ++ + + ++ EK LE + Sbjct: 945 HLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR 1004 Query: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYE---------ELIQVLK 558 M +D E + + +Q +K ++ + +YE + +++K Sbjct: 1005 LTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVK 1064 Query: 559 KEQDIYTHLVKSLQES---------------DSINNLQAELNKIFALRKQLEQDVLSYQN 603 + +D + L L+E + + L+ EL + A R+ LE D +S + Sbjct: 1065 QMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLER 1124 Query: 604 LRKTLEEQISEIR---RREEESFSLYSD-QTSYLSICLEENNRFQVE-HFSQEELKKKVS 658 K L+ +I + R +E + + + + L LE R + S L++KV Sbjct: 1125 QNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVK 1184 Query: 659 DLIQLVKELYTDNQHLKKT------IFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDT 712 +L+ V D++HL T L M Q + + E ++ +E E+ Sbjct: 1185 ELVMQV-----DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239 Query: 713 IKIGEDDEINFLSDQHLQ-QSNEIMKDL 739 + + E HLQ Q N + KDL Sbjct: 1240 MDMNE----------HLQGQLNSMKKDL 1257 Score = 70.1 bits (170), Expect = 2e-11 Identities = 103/491 (20%), Positives = 222/491 (45%), Gaps = 69/491 (14%) Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117 +N++ ++ +++ ++R+ L+E ++ G +E + + +L+ ++E LK + Sbjct: 801 KNVEVLASRSNTSEQDQAGTEMRVKLLQEE-NEKLQGRSEELERRVAQLQRQIEDLKGDE 859 Query: 118 QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAE 177 + ++ L K + L EA ARK ++ E + +R L E ++ AAQ Sbjct: 860 AKAKETLKKYEGEIRQLEEA--------LVHARK--EEKEAVSARRAL--ENELEAAQGN 907 Query: 178 L-----------EKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226 L EK +E ++ LR RL++++ E ++ H G L + D + Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLR-RLKNEM-ENERWHLGKTIEKLQKEMADIVEASR 965 Query: 227 KLSLKSKEALIQCLKEEKSQMACPD----ENVSSGELRGLCAAPREEKERETEAAQMEHQ 282 +L+ + L + ++ + ++A E E L A +++ R E ++Q Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025 Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342 + ++ + Q LE+ L++ E E+ E K+ LK D+ + +K E KV +L E+E Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYEL--EAKSHLKDDR-----SRLVKQMEDKVSQLEMELE 1078 Query: 343 K-------LSAAFAKAREALQKAQT---QEFQGSEDYETALSGKEALSAALRSQ--NLTK 390 + LS +++RE +++ + QE +D E E + L+S+ +L Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138 Query: 391 STENHR-------------LRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437 S + + L ++ ++ ++LQ RLE+ ++E + ++ Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198 Query: 438 DLRNE----VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTN--QKDV 491 D +++ ++ ++ +V E E+ ++ R +S + ++L Q + +HL N +KD+ Sbjct: 1199 DQKDQLSLRLKAMKRQVEEAEEEID-RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257 Query: 492 LLQKFNEKDLE 502 L+K K L+ Sbjct: 1258 RLKKLPSKVLD 1268 Score = 54.3 bits (129), Expect = 1e-06 Identities = 145/644 (22%), Positives = 248/644 (38%), Gaps = 123/644 (19%) Query: 1010 QPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENP 1069 QP + ++ G Q+ S+V R + + ++ E+ + A+ +N Sbjct: 463 QPNIDGKVLETEGSQE-----STVIRAPSLGAQSKKEEEVKT--------ATATLMLQNR 509 Query: 1070 EDVLSPTSVATYLSSKSQPSAKVSVMGTD----QSESINTSNET-------EYLKQKIHD 1118 SP S A +S K+ PSA + D Q E +NE YLK+ D Sbjct: 510 ATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTD 569 Query: 1119 LETELEGYQNFIFQ----LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE--EMTFS 1172 + + N +F+ L+ + S C + L + K+ E E+ Sbjct: 570 NDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629 Query: 1173 SLHQVRYVKHVKI--------LGPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQ 1222 +V+ +++K L L + + +V EN L+Q+LEE E +L+K Q Sbjct: 630 LQLEVKNQQNIKEERERMRANLEELRSQH-NEKVEENSTLQQRLEESEGELRKNLEELFQ 688 Query: 1223 LFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFE 1282 + E Q + RDL D L + S +R + ++ + E Sbjct: 689 VKMEREQHQTEIRDLQ----DQLSEMHDELDSAKRSEDREKGAL--------------IE 730 Query: 1283 ELLQASD--VDYCVAEGFQEQLNQCAELLEKLEKLFLNGK-SVGVEMNTQNELMERIEED 1339 ELLQA D +A+ QE +LL K E+ K ++ E+++ ++ M++++E Sbjct: 731 ELLQAKQDLQDLLIAKEEQE------DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784 Query: 1340 NLTYQHLLPESPEPSASHA---LSDYETSEKSFFSRD-------------QKQDNETEKT 1383 L ES E + + S TSE+ + Q + E E+ Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844 Query: 1384 SVMVNSFSQDL----------LMEHIQEIRTL-------RKRLEESIKTNEKLRKQLERQ 1426 + +DL L ++ EIR L RK +E++ L +LE Sbjct: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904 Query: 1427 GSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESL 1484 Q + +L + R +N+ N L K QKE + E+ Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964 Query: 1485 SRKTVSLEHLQREYASVKEENER----LQKEGSEKERHNQ-------QLIQEVRCSGQEL 1533 T+ L++ EY KE+N R +Q++ EK + ++ E+R +EL Sbjct: 965 RTSTLELQNQLDEY---KEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEEL 1021 Query: 1534 ---SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574 R Q+E ++QLL Q L+ L EL+A L ++ RL Sbjct: 1022 RDYQRAQDEALTKRQLLEQT---LKDLEYELEAKSHLKDDRSRL 1062 Score = 45.8 bits (107), Expect = 4e-04 Identities = 88/407 (21%), Positives = 164/407 (40%), Gaps = 66/407 (16%) Query: 1208 EQEYKLQKEQNLNMQLFSE-----IHNLQNKFRDLSPP---------RYDSLVQSQAREL 1253 E KL +E+N +Q SE + LQ + DL +Y+ ++ L Sbjct: 821 EMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880 Query: 1254 SLQRQQIKDGHGICVISRQHMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312 R++ K+ V +R+ + ++A + L Q + ++E +E+ Q E L +L Sbjct: 881 VHARKEEKEA----VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ-KEQLRRL 935 Query: 1313 EKLFLN-----GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASH-ALSDYETSE 1366 + N GK++ +++E L Q+ L E E + A + E Sbjct: 936 KNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995 Query: 1367 KSFFSRDQKQDNETEKTSVMVNSFSQDL-LMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425 K+ E EK+ + ++ LME +E+R ++ +E++ + L + L+ Sbjct: 996 KTL---------EAEKSRLTAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKD 1044 Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485 E E S L + L KQ + + L +++ +D L E +S Sbjct: 1045 LEYEL------------EAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092 Query: 1486 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEV-------RCSGQEL----- 1533 R +E L+ E + + L+ + ER N+ L + R S + L Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152 Query: 1534 SRVQE-EVKLRQQLLSQNDKLLQSLRVELKAYE---KLDEEHRRLRD 1576 +R+ E E +L + + + L + R+E K E ++D+EH L D Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199 Score = 41.2 bits (95), Expect = 0.009 Identities = 158/831 (19%), Positives = 313/831 (37%), Gaps = 138/831 (16%) Query: 818 HLDGKTEKTP-KQKGELVHFVQTNSFSKPHDELKLSCEAQLVK---AGEVPKVGLKDASV 873 ++DGK +T Q+ ++ + SK +E+K + +++ P G K SV Sbjct: 465 NIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISV 524 Query: 874 QTVATEG------DLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPG 927 +T + DLL+ + E T++ EE TA + L Sbjct: 525 KTFPSASNTQATPDLLKGQQELTQQTNEE----TAKQILYN-------------YLKEGS 567 Query: 928 ITNREAKKSRLPILIKPSRSL---------GNMYRLPATQEVVTQLQS------QILELQ 972 N +A K ++ ++ + ++L GN +T EV L+ ++ ELQ Sbjct: 568 TDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQ 627 Query: 973 GELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGE-QKGIKTTS 1031 +L+ + + ++ A +E + + + ++S GE +K ++ Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687 Query: 1032 SVWRDKE-------------------MDS-----DQQRSYEIDSEICPPDDLASLPSCKE 1067 V ++E +DS D+++ I+ + DL L KE Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747 Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127 ED+L + + ++ G + E + E + LK++ + EL+ + Sbjct: 748 EQEDLL-----------RKRERELTALKGALKEEVSSHDQEMDKLKEQY---DAELQALR 793 Query: 1128 NFIFQLQKHSQC----SEAIITVLCGTEGAQDGLSKPKNGSDG--EEMTFSSLHQVRYVK 1181 + + K+ + S GTE L + G EE+ R ++ Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853 Query: 1182 HVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHN-LQNKFRDLSPP 1240 +K G A + E +QLEE +KE+ + + N L+ +LS Sbjct: 854 DLK--GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911 Query: 1241 RYDSLVQSQA-RELSLQRQQIKDGHGICVISRQHMNTMI----KAFEELLQAS-----DV 1290 + S+ +E S Q++Q++ R H+ I K ++++AS ++ Sbjct: 912 TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLEL 971 Query: 1291 DYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPES 1350 + E ++ + AE+ +L++ L + + + M +EE+ YQ E+ Sbjct: 972 QNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA 1031 Query: 1351 --PEPSASHALSD--YETSEKSFFSRDQKQ--DNETEKTSVMVNSFSQ-----DLLMEHI 1399 L D YE KS D+ + +K S + + DLL E I Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERI 1091 Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLE-------RQGSEF------VQGSTSIFASG----- 1441 R ++L + R+ LE RQ + ++GS G Sbjct: 1092 SRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQM 1151 Query: 1442 ----SELHSSLTSEIHF---LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL 1494 +EL L SE L+ N+ L + + E+ L + + ++ L+ + Sbjct: 1152 EARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAM 1211 Query: 1495 QREYASVKEENERLQKEGSEKERH-NQQLIQEVRCSGQELSRVQEEVKLRQ 1544 +R+ +EE +RL+ + +R +Q+ GQ L+ ++++++L++ Sbjct: 1212 KRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ-LNSMKKDLRLKK 1261 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 104 bits (260), Expect = 7e-22 Identities = 296/1426 (20%), Positives = 569/1426 (39%), Gaps = 239/1426 (16%) Query: 206 HEGDLAMALVLDEKDRL---IEELKLSLKSKEALIQCLKEE-------KSQMACPDENV- 254 H G+ +AL D+ L +++L+ SLK ++ + LK+E + Q A PD V Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131 Query: 255 -SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEK--- 310 SS EL+ L E++ E AQ E+ I+ +++ +K ++ATE Sbjct: 132 DSSAELQSL--------EQQLEEAQTENFN--------IKQMKDLFEQKAAQLATEIADI 175 Query: 311 KNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYE 370 K+ +++++ ++ E+KV L E+ K + +Q +T+ Q + Sbjct: 176 KSKYDEERSLR------EAAEQKVTRLTEELNKEATV-------IQDLKTELLQRPGIED 222 Query: 371 TALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKS 430 A+ KE + N+T E R +K+ E LQ + E + + E + Sbjct: 223 VAVLKKELVQVQTLMDNMTLERE-----RESEKLKDECKKLQSQYASSEATISQLRSELA 277 Query: 431 KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490 KG + E++KL++ VNE + + ++LL + +E KH ES ++K+ Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE---KHNEESVSKKN 334 Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550 + ++KDL+ Q L A+E R ++EK + Q K K++ S+ Sbjct: 335 I-QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ---------KLKEELSEV 384 Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSIN-NLQAELN----KIFALRKQL--------EQD 597 E Q LK E + L + +E + LQ+E+N K+ +QL EQ Sbjct: 385 ETKYQHLKAE---FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441 Query: 598 VLSYQNLRKTLEEQISEIR----RREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE-- 651 LS + L E+Q+++++ R EE+ ++ T + + Q + Q+ Sbjct: 442 QLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500 Query: 652 --ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE- 708 +L++ +DL Q+++++ +Q ++ +L + Q + L E+ +L A + Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQ----NLEAL-LQKSKENISLLEKEREDLYAKIQA 555 Query: 709 -DEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS---KGGCKNGYLRHTESKISDCDGAHA 764 + +T + + E N + + Q E +K+ S K +N + + E K AH Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK------AHL 609 Query: 765 PGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTE 824 + + L NE + L ES+ + QL + + + L + Sbjct: 610 RAAQDR---VLSLETSVNELNSQLNESKEK---------VSQLDIQIKAKTELLLSAEAA 657 Query: 825 KTPKQKGELVHFVQT--NSFSKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGD 881 KT Q+ +L + + T N+ EL K++ + V A L+D E Sbjct: 658 KT-AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA------KLQDKQEHCSQLESH 710 Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPIL 941 L +K + LS E + E L G Q L + + +K+ L L Sbjct: 711 LKEYKEK-------------YLSLEQKTEELEG----QIKKLEADSLEVKASKEQALQDL 753 Query: 942 IKPSRSLGNMYRLPATQ---------EVVTQLQSQILELQGELKEFK-TCNKQLHQKLIL 991 + R L L AT+ E+V+ + + + L+ K KQ +K IL Sbjct: 754 -QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812 Query: 992 A---EAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDK-EMDSDQQRSY 1047 E + + + L N Q E++ + T S +DK SD ++ Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872 Query: 1048 EIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSN 1107 + + E A++ ++ +++ V + K Q K S+ Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL------------- 919 Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167 E K+ H L+ EL Q + Q Q + +E + Q +++ K S+ + Sbjct: 920 --EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK------EEQQLQGNINELKQSSEQK 971 Query: 1168 EMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN-LKQQLEEQEYKLQKEQNLNMQLFSE 1226 + +L G L ++ LEN L+QQL + +L E+ L + Sbjct: 972 KKQIEALQ-----------GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020 Query: 1227 IHNLQNKFRDLSPPRY--DSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEEL 1284 Q F+ L Y +S + + ++L +++ + +R + K +EL Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080 Query: 1285 LQA-SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTY 1343 A + ++ A+ Q+ +C L + ++ L K + +N +++L E IEE Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL---VNEKSKLAE-IEEIKCRQ 1136 Query: 1344 QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIR 1403 + + + E SH L E+ ++ +D KQ +K + + S +E Sbjct: 1137 EKEITKLNEELKSHKL---ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ----- 1188 Query: 1404 TLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN 1463 KR ++ +K ++++K+ E EF++ ++LHS + Sbjct: 1189 --EKRNQQILK--DQVKKEEEELKKEFIE-------KEAKLHSEI--------------- 1222 Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLI 1523 ++K+ K E+ ++ T+ + L +VK+E + Q+ SE E+ L Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275 Query: 1524 QEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE-LKAYEKLD 1568 E+ + Q+E + + + + ++ L+ + L+ KLD Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321 Score = 92.0 bits (227), Expect = 5e-18 Identities = 287/1346 (21%), Positives = 525/1346 (39%), Gaps = 228/1346 (16%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119 ++ E Q+ E + ENFN+K E++ Q L E+ +K + E Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ---------------LATEIADIKSKYDE 181 Query: 120 REQLLIKASKAVESLAEAGGSE---IQRVKED------------ARKKVQQVEDLLTKRI 164 L A + V L E E IQ +K + +K++ QV+ L+ Sbjct: 182 ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241 Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIE 224 L E++ + E +K + + +A +L S+L+ +G +A+ + E +L Sbjct: 242 LERERESEKLKDECKKLQSQYASSEATISQLRSELA------KGPQEVAVYVQELQKLKS 295 Query: 225 EL-KLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQK 283 + +L+ K++ LK+E+ +++ + A +K+ + + Q Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355 Query: 284 ERNSFEERIQALEE--DLREKEREIATEKKNSLKRDKA-IQGLTMALKSKEKKVEELNSE 340 S L E + +K +E +E + + KA + L + KE+ +L SE Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415 Query: 341 IEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR----------SQNLTK 390 I +L + + L +A + + + L KE A L+ + +T Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475 Query: 391 STENHRLRRSIKKITQELSDLQQ----ERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446 STE K+ QE LQQ + + DLE+ R+ D I++L ++K Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535 Query: 447 RNEVNEREKAMENRY---------KSLLSESNKKLHNQEQVIKHLTES-TNQKDVLLQKF 496 + ++ EK E+ Y ++L++ +K H ++ + LTE NQ + Q Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595 Query: 497 NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQV 556 +V +Q +L AA+D L E + E S+ SKEK D IQ+ Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNEL-------NSQLNESKEKVSQLD----IQI 644 Query: 557 -LKKEQDIYTHLVKSLQESDSINNL----------QAELNKIFALRKQLEQDVLSYQNLR 605 K E + K+ Q +D N+L Q ELNKI QL+Q Q+ + Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI---TTQLDQVTAKLQDKQ 701 Query: 606 KTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK 665 + + S ++ +E+ SL +T L + + + + + K++ +Q + Sbjct: 702 EHCSQLESHLKEYKEKYLSL-EQKTEELE---GQIKKLEADSLEVKASKEQALQDLQQQR 757 Query: 666 ELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTI--KIGEDDEINF 723 +L TD L+ +LS + + S+ + +L E ++I K+ + +E Sbjct: 758 QLNTD---LELRATELS----KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--- 807 Query: 724 LSDQHLQQSNEIMKDLSKGGCKNGYLRHTE--SKISDCDGAHAPGCLEEGAFINLLAPLF 781 Q L+Q E + +K ++H E ++I + L + Sbjct: 808 -EKQILKQDFETLSQETK-------IQHEELNNRIQ--------------TTVTELQKVK 845 Query: 782 NEKATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKT-----EKTPKQKGELV 834 EK L+ L + D L V + L ++ E E+ GK EKT K EL Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKN----SKSEFEKENQKGKAAILDLEKTCK---ELK 898 Query: 835 H--FVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE 892 H VQ + K ELK S E + +A K+ L Q + + L K E Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTL---KQNEKEE 954 Query: 893 AWEEKPIN-TALSAEHRPENLHGVPG-WQAALLSLPGITNR------------EAKKSRL 938 + IN S+E + + + + G + A+L + N+ A+K ++ Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014 Query: 939 PILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILA-EAVME 997 + L N Y +QE QLQS + EL + K + +KL LA E ++ Sbjct: 1015 SV-------LQNNYE--KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065 Query: 998 GR---PTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRD---------KEMDSDQQR 1045 R +K + + QDS +++ ++ +D KE+ +++ + Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125 Query: 1046 SYEIDSEICPPD-DLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESIN 1104 EI+ C + ++ L +E L T L Q + + +++S+ Sbjct: 1126 LAEIEEIKCRQEKEITKLN--EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183 Query: 1105 TSNETE-----YLKQKIHDLETELEGYQNFIFQLQK-HSQCSEAIITVLCGTEGAQDGLS 1158 + E E LK ++ E EL+ + FI + K HS+ E + G+ Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELK--KEFIEKEAKLHSEIKEKEV-----------GMK 1230 Query: 1159 KPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQN 1218 K + M ++L++ LG + E S + +LE+Q L+ E Sbjct: 1231 KHEENEAKLTMQITALNE--------NLGTVKKEWQSS---QRRVSELEKQTDDLRGEIA 1279 Query: 1219 LNMQLFSEIHNLQNKFRDLSP---PRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275 + L + + N Q++ R L + + Q + L LQR+ + + R++ + Sbjct: 1280 V---LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336 Query: 1276 TMIKAFEEL----LQASDVDYCVAEG 1297 IK + L + ++V C+A G Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCMACG 1362 Score = 76.6 bits (187), Expect = 2e-13 Identities = 150/735 (20%), Positives = 315/735 (42%), Gaps = 93/735 (12%) Query: 48 SEETVSPTR---ARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--- 101 SE T+S R A+ ++ + EL+K LK + L ++ Q TE++ K Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQK----LKSSVNELTQKNQTL----TENLLKKEQ 316 Query: 102 --TNIELKVEVESL-KRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVED 158 T +E K ES+ K+ +Q + ++S A + + R+ + +K + + Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376 Query: 159 LLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE 218 L + + +E +AE ++ E ++ L+L+S+++++ L E Sbjct: 377 L-KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK----------LLE 425 Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278 +R + E LK + L ++ ++ V+ +L+ L + KE+ T + + Sbjct: 426 TERQLGEAHGRLKEQRQL------SSEKLMDKEQQVADLQLK-LSRLEEQLKEKVTNSTE 478 Query: 279 MEHQKERNSFE-ERIQALEEDLREKEREIATEKKNSLK----RDKAIQGLTMAL-KSKE- 331 ++HQ ++ + + QAL++ K RE + + L+ +D+ IQ L L KSKE Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538 Query: 332 -----KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386 K+ E+L ++I+ A + +K T + Q ++ E + E+ A + Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA--QE 596 Query: 387 NLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIR--------- 437 NL + + ++ + L+ L L E+ + S+ D I+ Sbjct: 597 NLHDQVQEQKAH--LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654 Query: 438 ---------DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488 DL+N ++ +N + ++++ + N+ + L + KL +++ E +Q Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQEL-NKITTQLDQVTAKLQDKQ-------EHCSQ 706 Query: 489 KDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS 548 + L+++ EK L ++Q + + +L ++ L K S +Q + ++++ ++ Sbjct: 707 LESHLKEYKEKYLS-LEQKTEELEGQIKKLEADSL-EVKASKEQ---ALQDLQQQRQLNT 761 Query: 549 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608 D E L K+ ++ +V S + +LQ + + +++++L + Q L++ Sbjct: 762 DLELRATELSKQLEMEKEIVSSTR-----LDLQKKSEALESIKQKLTKQEEEKQILKQDF 816 Query: 609 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK-EL 667 E E + + EE + + L E E + ++ KVSD ++ K E Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876 Query: 668 YTDNQHLKKTIFDL--SCMGFQGNGFPDRLAST--EQTELLASKEDEDTIKIGEDDEINF 723 +NQ K I DL +C + + ++ +T EQ EL S E E E+N Sbjct: 877 EKENQKGKAAILDLEKTCKELK-HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935 Query: 724 LSDQHLQQSNEIMKD 738 + +Q +Q N + ++ Sbjct: 936 MQEQLIQAQNTLKQN 950 Score = 76.3 bits (186), Expect = 3e-13 Identities = 145/759 (19%), Positives = 330/759 (43%), Gaps = 118/759 (15%) Query: 59 NMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ 118 ++ + +Q+ E K++ L ++I E + T +L+ +++ + LQ Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ----RADLQNHLDTAQNALQ 677 Query: 119 EREQLLIKASKAVESLA------EAGGSEIQRVKEDARKK---VQQVEDLLTKRILLLEK 169 +++Q L K + ++ + + S+++ ++ ++K ++Q + L +I LE Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737 Query: 170 DVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLS 229 D +A E+A + ++ L LE + +E+ K L+ + ++ +L Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ----------LEMEKEIVSSTRLD 787 Query: 230 LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289 L+ K ++ +K++ ++ + + +++ E ++ +++H++ N + Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQIL------------KQDFETLSQETKIQHEELNNRIQ 835 Query: 290 ERIQALEEDLREKE---REIATEK------KNSLKR-----DKAIQGLTMALKSKEKKVE 335 + L++ EKE E++T K +SLK +K Q A+ EK + Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895 Query: 336 ELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST--E 393 EL +++ K ++ L+K+ +E + S + L+ + +++QN K E Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQNEKE 953 Query: 394 NHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTI--------RDLRNEVEK 445 +L+ +I ++ Q +++ E L+ +L+ A +K++ + + ++L E EK Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013 Query: 446 LRNEVNEREKAMENRYKSLLSE---SNKKLHNQEQVIKHLTE--STNQKDVLLQKFNEKD 500 + N EK+ E +K L S+ +L Q +K + E S Q+D++ + + Sbjct: 1014 ISVLQNNYEKSQET-FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072 Query: 501 LEVIQQNCYLMAA--EDLELRSEGLITEKCSS-QQPPGSKTIFSK----EKKQSSDYEEL 553 + Q A E + E + E+C + Q K++ K EK + ++ EE+ Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132 Query: 554 -----IQVLKKEQDIYTHLVKSLQESDSINNLQAEL--------NKIFALRKQLEQDVLS 600 ++ K +++ +H ++S++E ++ + + L K +L+ +EQ+ + Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192 Query: 601 YQNLRKTLEEQISEIR--------------RREEESFSLYSDQTSYLSI---CLEEN--- 640 Q L+ ++++ E++ + +E + + + L++ L EN Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252 Query: 641 --NRFQVEHFSQEELKKKVSDL---IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL 695 +Q EL+K+ DL I +++ +NQ ++ + + C+ +G G ++L Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE-RCL--KGEGEIEKL 1309 Query: 696 ASTEQTELLASKEDEDTIKIGE-DDEINFLSDQHLQQSN 733 T+ E L K D T + E E L +H Q N Sbjct: 1310 -QTKVLE-LQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346 Score = 71.2 bits (173), Expect = 8e-12 Identities = 249/1251 (19%), Positives = 477/1251 (38%), Gaps = 222/1251 (17%) Query: 385 SQNLTKSTENHR-LRRSIKKITQELSDLQQERERLEKDLEEAHRE-------KSKGDCTI 436 S+ L K E ++ L++ K ++D E + LE+ LEEA E K + Sbjct: 106 SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA 165 Query: 437 RDLRNEVEKLRNEVNERE---KAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLL 493 L E+ ++++ +E +A E + L E NK+ + + L + +DV + Sbjct: 166 AQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAV 225 Query: 494 QKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE--KCSSQQPPGSKTIFSKEKKQSSDYE 551 K ++ + N L + E SE L E K SQ TI + + + Sbjct: 226 LKKELVQVQTLMDNMTL----ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281 Query: 552 ELIQVLKKEQDIYTHLVKSLQESDSIN-NLQAELNKIFALRKQLEQDVLSYQNLRKTLEE 610 E+ +++ Q + + + + Q++ ++ NL + L ++ ++ +S +N++ TL + Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341 Query: 611 QISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTD 670 + + ++ + L + +TS I +E + + + +EEL E+ T Sbjct: 342 KDLDCQQLQSR---LSASETSLHRIHVELSEKGEATQKLKEELS-----------EVETK 387 Query: 671 NQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQ 730 QHLK E +L +E+++ + EIN L + L+ Sbjct: 388 YQHLK----------------------AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425 Query: 731 QSNEIMKDLSKGGCKNGYLRH----TESKISDCDGAHAPGCLEEGAFINLLAPLFNEKAT 786 ++ G +G L+ + K+ D + A L+ ++ L EK T Sbjct: 426 TERQL-------GEAHGRLKEQRQLSSEKLMDKEQQVADLQLK----LSRLEEQLKEKVT 474 Query: 787 LLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPH 846 E + L K ++ Q E+ +Q G+ +Q Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ-------- 526 Query: 847 DELKLSCEAQLVKAGEVPKVGLKD-----ASVQTVATEGDLLRFKHEATREAWE------ 895 + EA L K+ E + K+ A +Q E +L E E Sbjct: 527 -----NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLT 581 Query: 896 EKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLP 955 EK N + S + ENLH Q A L A + R+ L L + +L Sbjct: 582 EKLKNQSESHKQAQENLHDQVQEQKAHL--------RAAQDRVLSLETSVNELNS--QLN 631 Query: 956 ATQEVVTQLQSQI---LELQGELKEFKTCNK-QLHQKLILAEAVMEGRPTPDKTLLNAQP 1011 ++E V+QL QI EL + KT + L L A+ ++ + + Sbjct: 632 ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691 Query: 1012 PVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071 V A QD +++ +++K + S +Q++ E++ +I K+ D Sbjct: 692 QVTAKLQDKQEHCSQLESHLKEYKEKYL-SLEQKTEELEGQI------------KKLEAD 738 Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE---TEYLKQKIHDLETELEGYQN 1128 L + SK Q ++ Q +NT E TE KQ LE E E + Sbjct: 739 SLEVKA------SKEQ-----ALQDLQQQRQLNTDLELRATELSKQ----LEMEKEIVSS 783 Query: 1129 FIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188 LQK S+ E+I + L+K + + F +L Q ++H Sbjct: 784 TRLDLQKKSEALESI----------KQKLTKQEEEKQILKQDFETLSQETKIQH------ 827 Query: 1189 LAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQS 1248 E +++R+ + E Q+ K++KE L +E+ +++K +S DSL S Sbjct: 828 ---EELNNRIQTTVT---ELQKVKMEKEA-----LMTELSTVKDKLSKVS----DSLKNS 872 Query: 1249 QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAEL 1308 ++ E + Q+ K + + K +EL V + L + EL Sbjct: 873 KS-EFEKENQKGKAA----------ILDLEKTCKELKHQLQVQ------MENTLKEQKEL 915 Query: 1309 LEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368 + LEK + +E+N+ E + I+ N Q+ E + L +K Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQL--IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973 Query: 1369 FFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGS 1428 Q + + + Q L + QE+ ++++ EK ++ ++ S Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033 Query: 1429 EFVQGSTSIFASGSELHS----------SLTSEIHFLRKQNQALNAMLIKGSRDKQKEND 1478 +F + + A+ +L S L S + + QN+ + L ++++ Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE-LKTAKATLEQDSA 1092 Query: 1479 KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ-ELSRVQ 1537 K + L + +L+ +Q+E + L+++ E+ I+E++C + E++++ Sbjct: 1093 KKEQQLQERCKALQDIQKE--------KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144 Query: 1538 EEVKLRQ--------------QLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574 EE+K + QLL Q LQ LKA + ++ ++++ Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195 Score = 58.5 bits (140), Expect = 6e-08 Identities = 204/1078 (18%), Positives = 424/1078 (39%), Gaps = 123/1078 (11%) Query: 575 DSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLS 634 D + L+ E+ L+ L+++ + L+K LE+ ++++E + L +D ++ L Sbjct: 83 DDVTLLRQEVQD---LQASLKEEKWYSEELKKELEKY-QGLQQQEAKPDGLVTDSSAELQ 138 Query: 635 ICLEENNRFQVEHFSQEELK----KKVSDL---IQLVKELYTDNQHLKKTIFDLSCMGFQ 687 ++ Q E+F+ +++K +K + L I +K Y + + L++ + Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198 Query: 688 GNGFPDRLASTEQTELLASKEDEDTIKIGED-DEINFLSDQHLQQSNEIMKDLSKGGCKN 746 + +TELL ED + ++ ++ L D ++ E + K CK Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERESEKLKDECKK 257 Query: 747 GYLRH--TESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRP---DLLKVVRE 801 ++ +E+ IS A G E ++ L L + L +++ +LLK ++ Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317 Query: 802 LLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN--SFSKPHDELKLSCEAQLVK 859 + E+ VS +++ + +L + + S + H EL EA Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377 Query: 860 AGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWE-EKPINTA----LSAEHRPENLHG 914 E+ +V K ++ A L + + E + + + IN L E + HG Sbjct: 378 KEELSEVETKYQHLK--AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435 Query: 915 VPGWQAALLSLP------GITNREAKKSRLPILIKP--SRSLGNMYRLPATQEVVTQLQS 966 Q L S + + + K SRL +K + S ++L T++ + Q+ Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495 Query: 967 -------QILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQD 1019 ++ E Q +L++ QK+ EA+++ L + + A Q Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555 Query: 1020 SPGE--------QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071 GE +K V + E +Q S++ E + + Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615 Query: 1072 VLS-PTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIH-DLETELEGYQNF 1129 VLS TSV S ++ KVS + E K DL+ L+ QN Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675 Query: 1130 IFQLQKH-SQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188 + Q+ ++ + + V + Q+ S+ ++ + + SL Q K ++ G Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ----KTEELEGQ 731 Query: 1189 LAPEMIDSRVLENLKQQ-LEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQ 1247 + DS ++ K+Q L++ + + Q +L ++ L+ + +S R D + Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791 Query: 1248 SQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAE 1307 S+A E S++++ K + + + FE L Q + + + +E N+ Sbjct: 792 SEALE-SIKQKLTKQ--------EEEKQILKQDFETLSQETKIQH------EELNNRIQT 836 Query: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEK 1367 + +L+K+ + +++ E++T + + ++ SD + K Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKV-----------------------SDSLKNSK 873 Query: 1368 SFFSRDQKQDN----ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQL 1423 S F ++ ++ + EKT + Q + ++E + L+K LE+ + + +L+ +L Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933 Query: 1424 ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR-------KQNQALNAMLIKGSRDKQKE 1476 + +Q ++ + E L I+ L+ KQ +AL L K + Sbjct: 934 NSMQEQLIQAQNTLKQNEKE-EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992 Query: 1477 NDKLRESLSRKTVSLEH-------LQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529 +KL++ L++ L LQ Y +E ++LQ + +E Q+++ Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052 Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLRV--------ELKAYEKLDEEHRRLRDGDK 1579 ++LS QE++ + + +KL+Q L+ K ++L E + L+D K Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK 1110 Score = 53.9 bits (128), Expect = 1e-06 Identities = 132/681 (19%), Positives = 270/681 (39%), Gaps = 99/681 (14%) Query: 949 GNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLN 1008 G L ++ VT L+ ++ +LQ LKE K +++L ++L + + + PD + + Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132 Query: 1009 AQPPVGAAYQ---DSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSC 1065 + + + Q ++ E IK ++ K Q + EI D+ SL Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA----AQLATEIADIKSKYDEERSLREA 188 Query: 1066 KEN-----PEDVLSPTSVATYLSSK--SQPSAK---------VSVMGTDQSESINTSNET 1109 E E++ +V L ++ +P + V V + ++ E+ Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248 Query: 1110 EYLKQKIHDLETELEGYQNFIFQLQ----KHSQCSEAIITVLCGTEGAQDGLSKPKNGSD 1165 E LK + L+++ + I QL+ K Q + L + + + L++ KN + Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ-KNQTL 307 Query: 1166 GE-----EMTFSSL---HQVRYVKHVKILGPLAPEMIDSRVLEN----LKQQLEEQEYKL 1213 E E ++ L H V I L + +D + L++ + L +L Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367 Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS--R 1271 ++ +L E+ ++ K++ L +++ ++L QR++ K+ HG+ + S Sbjct: 368 SEKGEATQKLKEELSEVETKYQHL---------KAEFKQLQQQREE-KEQHGLQLQSEIN 417 Query: 1272 QHMNTMIKAFEELLQA----SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMN 1327 Q + +++ +L +A + +E ++ Q A+L KL +L + + ++ Sbjct: 418 QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVT 474 Query: 1328 TQNELMERIEEDNLTY--QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385 EL ++++ + Q L +S A +D E + +DQK Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK---------- 524 Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445 IQ + L ++ +E+I EK R+ L + + +G T++ Sbjct: 525 -------------IQNLEALLQKSKENISLLEKEREDLYAK-IQAGEGETAVL------- 563 Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505 + L + H L++Q L L S ++ + L + + + L Q S++ Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623 Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN-----DKLLQSLRVE 1560 L + +E + QL +++ EL E K Q+ QN LQ + E Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAK-TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682 Query: 1561 L-KAYEKLDEEHRRLRDGDKY 1580 L K +LD+ +L+D ++ Sbjct: 683 LNKITTQLDQVTAKLQDKQEH 703 Score = 53.5 bits (127), Expect = 2e-06 Identities = 87/451 (19%), Positives = 182/451 (40%), Gaps = 34/451 (7%) Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393 E ++++ YQ L + +P ++D +S + ++ E M + F Q Sbjct: 107 EELKKELEKYQGLQQQEAKPDG--LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQK 164 Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSEL-HSSLTSEI 1452 + EI ++ + +E E +++ R E + +T I +EL ++ Sbjct: 165 AA-QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223 Query: 1453 HFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEG 1512 L+K+ + ++ + ++++E++KL++ + LQ +YAS + +L+ E Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKK-------LQSQYASSEATISQLRSEL 276 Query: 1513 SEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHR 1572 ++ QEV QEL +++ V +L +N L ++L + + Y KL+E+H Sbjct: 277 AKGP-------QEVAVYVQELQKLKSSVN---ELTQKNQTLTENLLKKEQDYTKLEEKHN 326 Query: 1573 RLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETP--------PLSGNDTDSLSCDSGSSA 1624 K + + DL D Q + S SET G T L + Sbjct: 327 EESVSKKNIQATLHQKDL-DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385 Query: 1625 TSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTS 1684 T + + +H L L + L ++ + +R L E + +E +S Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445 Query: 1685 QELGTKGPHPAPL----SKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG 1740 ++L K A L S+ + E +L + + ++ Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505 Query: 1741 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSK 1771 E + ++ ++ +++ ++++K+QN LLQ SK Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 103 bits (258), Expect = 1e-21 Identities = 139/658 (21%), Positives = 278/658 (42%), Gaps = 101/658 (15%) Query: 60 MKDFENQITE-------LKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVES 112 + D E+++ E L+ E ++ I LEE++ +E G + + + + +++ Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGARQKLQLEKVTAEAKIKK 982 Query: 113 LKRE---LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARK--KVQQVEDLLTKRILLL 167 ++ E L+++ IK K +E S++ +E A+ K++ ++++ + Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042 Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK 227 K + ELEKA + +L+ + ++++ + E I+ELK Sbjct: 1043 LKKEEKTRQELEKA----------KRKLDGETTDLQDQ----------IAELQAQIDELK 1082 Query: 228 LSLKSKEALIQCLKEEKSQMACPDENVSS--GELRGLCAAPREEKERETEAAQMEHQKER 285 L L KE +Q N EL+ A +E+ E E +A++ + +K++ Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQK 1141 Query: 286 NSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLS 345 E ++AL+ +L + A +++ KR++ + L AL+ + K E ++I+ + Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE---AQIQDMR 1198 Query: 346 AAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKIT 405 A A E L SE E A + A L T+N L +K + Sbjct: 1199 QRHATALEEL----------SEQLEQA----KRFKANLEKNKQGLETDNKELACEVKVLQ 1244 Query: 406 QELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLL 465 Q ++ + +R++L+ ++E H + S+GD +L + KL+NE+ + +LL Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL--------DNVSTLL 1296 Query: 466 SESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525 E+ KK + L LLQ+ + L +L R L Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL-------------NLSSRIRQLEE 1343 Query: 526 EKCSSQQPPGSKTIFSKE-KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL 584 EK S Q+ + K +KQ + + KK+ D ++SL+E+ AE Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE- 1402 Query: 585 NKIFALRKQLEQDVLSYQNLRKT---LEEQI--------------SEIRRREEESFSLYS 627 AL ++LE+ L+Y L KT L++++ S + +++++ L + Sbjct: 1403 ----ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458 Query: 628 DQTSYLSICLEENNRFQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681 ++ S + EE +R + E +E L + + + ++ +E N+ L+ + DL Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516 Score = 95.1 bits (235), Expect = 5e-19 Identities = 131/581 (22%), Positives = 250/581 (43%), Gaps = 63/581 (10%) Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-RILLLEKDVTAAQAELE-KA 181 L++ ++ E L +A E+ +VKE K ++E++ K + LL EK++ A Q + E + Sbjct: 844 LLQVTRQEEEL-QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902 Query: 182 FAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK 241 FA E +R RL +K E++++ + +E++++++ K K +A IQ L+ Sbjct: 903 FAEAE---EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK---KKMQAHIQDLE 956 Query: 242 EEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-----KERNSFEERIQALE 296 E+ + +E A + K+ E E +E Q KE+ E+RI Sbjct: 957 EQLDE----EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012 Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356 L E+E + K K++ I L LK +EK +EL KL ++ + Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072 Query: 357 KAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415 + Q Q ++ + L+ K E L AL + +N+ L K+ +E LQ + Sbjct: 1073 ELQAQ----IDELKLQLAKKEEELQGALARGDDETLHKNNAL-----KVVRE---LQAQI 1120 Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE--------------REKAMENRY 461 L++D E ++K + RDL E+E L+ E+ + RE+ + Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180 Query: 462 KSLLSES-NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRS 520 K+L E+ N + Q+ +H T + L Q K +++N + ++ EL Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK--ANLEKNKQGLETDNKELAC 1238 Query: 521 EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNL 580 E + ++ ++ K KK + +EL + + + L ++ + L Sbjct: 1239 EVKVLQQVKAESE-------HKRKKLDAQVQELHAKVSEGDRLRVEL------AEKASKL 1285 Query: 581 QAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640 Q EL+ + L ++ E+ + + +LE Q+ + + +E + +S + EE Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345 Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681 N Q + +EE +K + + ++ D + KK DL Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTK--KKVDDDL 1384 Score = 76.3 bits (186), Expect = 3e-13 Identities = 131/621 (21%), Positives = 254/621 (40%), Gaps = 105/621 (16%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEER------MQQEFHGPTEHIYKTNIELKVEVESL 113 ++D + + E ++ NL RI LEE Q+E +++ K + L+ ++ Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376 Query: 114 KRE----------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK- 162 K++ L+E ++ L+K ++A+ E ++++ + Q+++DL Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436 Query: 163 ------------------RILLLEKDVTAAQAE---------LEKAFAGTETEKALRLRL 195 ++L EK ++A AE EK +AL L Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496 Query: 196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 E+K ++ + M ++ KD + + + KSK AL Q ++E ++Q+ ++ + Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556 Query: 256 SGELRGLCAAPREEKERETEAAQMEH--QKERNSFEERIQALEEDLREKEREIATEKKNS 313 + E L R E + AQ E Q EE+ + L + +RE E E+ E+K Sbjct: 1557 ATEDAKL----RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ- 1611 Query: 314 LKRDKAIQGLTMALKSK-EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETA 372 + L +A K K E +++L ++IE A KAR+ + K + +DY+ Sbjct: 1612 -------RALAVASKKKMEIDLKDLEAQIE----AANKARDEVIKQLRKLQAQMKDYQRE 1660 Query: 373 LSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKG 432 L + A R + +S E+ + +K + E+ LQ+E E+ A +E+ Sbjct: 1661 LEE----ARASRDEIFAQSKES---EKKLKSLEAEILQLQEELASSERARRHAEQER--- 1710 Query: 433 DCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ-EQVIKHLTESTNQKDV 491 ++L +E+ KS L + ++L + Q+ + L E + ++ Sbjct: 1711 -----------DELADEITNSASG-----KSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754 Query: 492 LLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE--------KCSSQQPPGS-----KT 538 L +F + L+V N L A +S+ + K Q+ G+ K Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814 Query: 539 IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA--LRKQLEQ 596 S + + EE ++ KE+ LV+ ++ +Q E + A ++Q+E+ Sbjct: 1815 TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874 Query: 597 DVLSYQNLRKTLEEQISEIRR 617 + L++ LEE E R Sbjct: 1875 ANARMKQLKRQLEEAEEEATR 1895 Score = 68.2 bits (165), Expect = 7e-11 Identities = 113/508 (22%), Positives = 211/508 (41%), Gaps = 107/508 (21%) Query: 57 ARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRE 116 A N++ + + +L E ++ R + EER + E + ++ +E +E Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISAR--YAEERDRAEAEAREKETKALSLARALEEALEAKE 1500 Query: 117 LQEREQLLIKAS-KAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175 ER+ ++A + + S + G + +++ R QQVE++ T+ LE Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ----LE------- 1549 Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDR--LIEELK------ 227 ELE TE K LRLE + MK E DL +E+ + LI++++ Sbjct: 1550 -ELEDELQATEDAK---LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605 Query: 228 --------LSLKSKEALIQCLKEEKSQMACP----DENVSSGELRGLCAAPREEKERETE 275 L++ SK+ + LK+ ++Q+ DE + +LR L A ++ +RE E Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK--QLRKL-QAQMKDYQRELE 1662 Query: 276 AAQM----------EHQKERNSFEERIQALEEDLREKER----------EIATEKKNSLK 315 A+ E +K+ S E I L+E+L ER E+A E NS Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722 Query: 316 RDKAIQGLTMALKSK----EKKVEELNSEIEKLSAAFAK--------------------- 350 A+ L+++ E+++EE S +E L+ F K Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK 1782 Query: 351 ---AREALQ------KAQTQEFQGS--EDYETALSGKEA----LSAALRSQNLTKSTENH 395 AR+ L+ KA+ QE +G+ ++ +S EA L L + ++ N Sbjct: 1783 SDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANK 1842 Query: 396 RLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK 455 +RR+ KK+ + ++ ER ++ E + K + ++ L+ ++E+ E Sbjct: 1843 LVRRTEKKLKEIFMQVEDERRHADQYKE----QMEKANARMKQLKRQLEEAEEEATRANA 1898 Query: 456 AMENRYKSL--LSESNKKLHNQEQVIKH 481 + + L +E+N+ L + +K+ Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKN 1926 Score = 62.0 bits (149), Expect = 5e-09 Identities = 152/786 (19%), Positives = 318/786 (40%), Gaps = 101/786 (12%) Query: 1087 QPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEG-------YQNFIFQLQKHSQC 1139 Q A+ + + + + + L++ +HDLE+ +E QN ++Q H Q Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954 Query: 1140 SEAIITVLCGTEGAQDGLSKPKNGSDG------EEMTFSSLHQVRYVKHVKIL------- 1186 E L EGA+ L K ++ EE+ +++K K++ Sbjct: 955 LEE---QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011 Query: 1187 -GPLAPEMIDSRVLENLKQQLE----EQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPR 1241 LA E ++ L ++ + E + E +L+KE+ +L L + DL Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071 Query: 1242 YDSLVQSQARELSLQ----RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG 1297 + +Q+Q EL LQ ++++ H N +K EL QA + + E Sbjct: 1072 AE--LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAE--LQED 1126 Query: 1298 FQEQL-------NQCAELLEKLEKL------FLNGKSVGVEMNTQNE-----LMERIEED 1339 F+ + Q +L E+LE L L+ + E+ T+ E L + +EE+ Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186 Query: 1340 NLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHI 1399 ++ + + + HA + E SE+ ++ K + E K + ++ E Sbjct: 1187 TKNHEAQIQDMRQ---RHATALEELSEQLEQAKRFKANLEKNKQGLETDN------KELA 1237 Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGS---TSIFASGSELHSSLTSEIHFLR 1456 E++ L++ ES +KL Q++ ++ +G + S+L + L + + L Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN-VSTLL 1296 Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKE 1516 ++ + K + + + +E L +T +L ++EE LQ++ E+E Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356 Query: 1517 RHNQQLIQEVRCSGQELSRVQEEV-----------KLRQQLLSQNDKLLQSLRVELKAYE 1565 + L ++V +L+ +++V + +++LL + L Q L + AY+ Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416 Query: 1566 KLDEEHRRL-RDGDKYPMESDNSFDL---FDSSQAVTPKSVSETPPLS---GNDTDSLSC 1618 KL++ RL ++ D ++ D+ + + Q + ++E +S + D Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476 Query: 1619 DSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQE 1678 ++ T ++R + + R L D E L+ + + E++ +++ Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE-KSKR 1535 Query: 1679 APSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSL-----PEDGQCP 1733 A +E+ T+ L + + AKL LE + +K + L + + Sbjct: 1536 ALEQQVEEMRTQ---LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592 Query: 1734 LHCEQIGEMKAEVTKLHKK---LFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRK 1790 L +Q+ E++AE+ K+ +KK++ +K L+ D+++ K LRK Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI---KQLRK 1649 Query: 1791 ARGNLE 1796 + ++ Sbjct: 1650 LQAQMK 1655 Score = 53.5 bits (127), Expect = 2e-06 Identities = 114/567 (20%), Positives = 224/567 (39%), Gaps = 62/567 (10%) Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVE-MNTQNELMERIEEDN 1340 EE LQA D + + Q ++ E +E+ + L K++ E + + EL EE Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910 Query: 1341 LTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEH-- 1398 E E L D E+ + R+Q NE +K + + L E Sbjct: 911 ARLAAKKQELEE-----ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965 Query: 1399 IQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT--------- 1449 Q+++ + E IK E+ LE Q S+F++ + +E S L Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025 Query: 1450 -----------SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREY 1498 S++ K+ + L K R E L++ ++ ++ L+ + Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085 Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558 A +EE + G ++ H ++ VR +++ +QE+ + + ++ +K + L Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145 Query: 1559 VELKAY-----EKLD-----EEHRRLRDGD----KYPMESD---NSFDLFDSSQ--AVTP 1599 EL+A + LD +E R R+ + K +E + + + D Q A Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATAL 1205 Query: 1600 KSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALL 1659 + +SE + +L + T ++ V +++ L + L Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265 Query: 1660 KQISQGQRL---LAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSV-----STAKLTL 1711 ++S+G RL LAE + Q + S L +K +S+ T +L Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325 Query: 1712 EEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKA------EVTKLHKKLFEQEKKLQNTMK 1765 EE ++L L R+ E+ + L +Q E +A +V L +L + +KK+ + + Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385 Query: 1766 LLQ-LSKRQEKVIFDQLVVTHKILRKA 1791 ++ L + ++K++ D ++ ++ KA Sbjct: 1386 TIESLEEAKKKLLKDAEALSQRLEEKA 1412 Score = 49.7 bits (117), Expect = 3e-05 Identities = 193/1047 (18%), Positives = 401/1047 (38%), Gaps = 155/1047 (14%) Query: 553 LIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQL--EQDVLSYQNLRKT--- 607 L+QV ++E+++ + L+ + ++ EL ++ +QL E+++L+ Q +T Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903 Query: 608 --LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK 665 EE + + +++E + D S + EE R Q+ +++++ + DL + + Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVE---EEEERNQILQNEKKKMQAHIQDLEEQLD 960 Query: 666 ELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLS 725 E G +L + T K+ E+ I + ED F+ Sbjct: 961 E---------------------EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999 Query: 726 DQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKA 785 ++ L E +I++C A EE LA + N++ Sbjct: 1000 EKKLM----------------------EDRIAECSSQLA----EEEEKAKNLAKIRNKQE 1033 Query: 786 TLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKP 845 ++ + L K + E E + LDG+T Q EL + Sbjct: 1034 VMISDLEERLKKEEKTR-------QELEKAKRKLDGETTDLQDQIAELQAQI-------- 1078 Query: 846 HDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSA 905 DELKL QL K E + L +T+ L + + A ++ + ++ Sbjct: 1079 -DELKL----QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133 Query: 906 EHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQ 965 ++ E + L + ++ + K + + + + A +E + Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK--ALEEETKNHE 1191 Query: 966 SQILEL-QGELKEFKTCNKQLHQ-KLILA--EAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021 +QI ++ Q + ++QL Q K A E +G T +K L + +S Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251 Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDV-LSPTSVAT 1080 ++K + K + D+ R + ++L ++ + E E + A Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311 Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140 L S+ Q + ++ + + + +N S+ L+++ + L+ + E + L+K Sbjct: 1312 SLESQLQDTQEL--LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ---- 1365 Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVR--YVKHVKILGP-LAPEMIDSR 1197 Q L+ K D + T SL + + +K + L L + + Sbjct: 1366 ---------VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416 Query: 1198 VLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDL-SPPRYDSLVQSQARELSLQ 1256 LE K +L+++ L + + Q+ S + Q KF L + + S ++ R+ + Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476 Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC-AELLEKLEKL 1315 + K+ + ++ +A EE L+A E F+ Q Q A++ + + Sbjct: 1477 EAREKETKAL---------SLARALEEALEAK-------EEFERQNKQLRADMEDLMSSK 1520 Query: 1316 FLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRD- 1373 GK+V ++ L +++EE + L E A L + K+ F RD Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580 Query: 1374 QKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG 1433 Q +D + E+ ++ I+++R L LE+ E+ ++ L + ++ Sbjct: 1581 QTRDEQNEEKKRLL-----------IKQVRELEAELED-----ERKQRALAVASKKKMEI 1624 Query: 1434 STSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEH 1493 + E + E+ KQ + L A + +D Q+E ++ R S + Sbjct: 1625 DLKDLEAQIEAANKARDEVI---KQLRKLQAQM----KDYQRELEEARASRDEIFAQSKE 1677 Query: 1494 LQREYASVKEENERLQKEGSEKER-------HNQQLIQEVRCSGQELSRVQEEVKLRQQL 1546 +++ S++ E +LQ+E + ER +L E+ S S + +E +++L Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE---KRRL 1734 Query: 1547 LSQNDKLLQSLRVELKAYEKLDEEHRR 1573 ++ +L + L E E L++ R+ Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRK 1761 Score = 46.6 bits (109), Expect = 2e-04 Identities = 91/453 (20%), Positives = 179/453 (39%), Gaps = 94/453 (20%) Query: 58 RNMKDFENQITELKKE---NFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK----VEV 110 + +++ Q+ EL+ E + KLR+ + M+ +F + + N E K +V Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598 Query: 111 ESLKRELQE--REQLLIKASKA--------VESLAEAGGSEIQRVKEDARKKVQQVEDLL 160 L+ EL++ +++ L ASK +E+ EA V + RK Q++D Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY- 1657 Query: 161 TKRILLLEKDVTAAQAELEKAFAGT-ETEKALRLRLESKLSEMKKMHEGDLAMALVLDEK 219 ++++ A+A ++ FA + E+EK L+ L +++ + A E+ Sbjct: 1658 -------QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710 Query: 220 DRLIEELKLSLKSKEALI--------------QCLKEEKSQMACPDEN-----VSSGELR 260 D L +E+ S K AL+ + L+EE+S M ++ + L Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770 Query: 261 GLCAAPREEKERETEAAQ-MEHQKER--------------------NSFEERIQALEEDL 299 AA R ++ A Q +E Q + ++ E +I LEE L Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQL 1830 Query: 300 REKEREIATEKKNSLKRDKAIQGLTMA---------------------LKSKEKKVEELN 338 ++ +E A K + +K ++ + M +K ++++EE Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890 Query: 339 SEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLR 398 E + +A+ K + L A T+ +G + L + + S+ + R + Sbjct: 1891 EEATRANASRRKLQRELDDA-TEANEGLSREVSTLKNRLRRGGPIS----FSSSRSGRRQ 1945 Query: 399 RSIKKITQELSDLQQERERLEKDLEEAHREKSK 431 ++ + ELSD + E D+ E +S+ Sbjct: 1946 LHLEGASLELSD--DDTESKTSDVNETQPPQSE 1976 Score = 40.4 bits (93), Expect = 0.016 Identities = 55/287 (19%), Positives = 123/287 (42%), Gaps = 43/287 (14%) Query: 1484 LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE---EV 1540 ++R+ L+ E VKE+ +++ E E ER +QQL++E ++L E E Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906 Query: 1541 KLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMES--DNSFDLFDSSQAVT 1598 + + L+ + L+ + +L++ + +EE ++ +K M++ + + D + Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966 Query: 1599 PKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL 1658 K E T+ + ++ L +N + I++ + + Sbjct: 967 QKLQLE------------------KVTAEAKIKKMEEEILLLEDQNSK----FIKEKKLM 1004 Query: 1659 LKQISQGQRLLAEMDIQTQE-APSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRR 1717 +I++ LAE + + + A QE+ + L + + + LE+A R+ Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMI-----SDLEERLKKEEKTRQELEKAKRK 1059 Query: 1718 LKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTM 1764 L DG+ +QI E++A++ +L +L ++E++LQ + Sbjct: 1060 L----------DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096 >gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [Homo sapiens] Length = 1132 Score = 103 bits (257), Expect = 2e-21 Identities = 116/488 (23%), Positives = 224/488 (45%), Gaps = 43/488 (8%) Query: 202 MKKMHEGDLAMALVLDEKDRLIEEL---KLSLKSKEALIQCLKEEK---SQMACPDENVS 255 +K +++ ++ L L + L ++L L L+ + + LK++K + ++VS Sbjct: 341 LKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVS 400 Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315 L L +EK ++TEA + L+E L E E+ +++S K Sbjct: 401 DSHLAEL-----QEKIQQTEATN--------------KILQEKLNEMSYELKCAQESSQK 441 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375 +D IQ L LKS+E++ EEL IE + AK RE L ++Q + SE T+ + Sbjct: 442 QDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQ 499 Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435 ++ L+S E +L+R +++ ++L+D +Q + +E E+ ++K Sbjct: 500 QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 559 Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495 ++LR +++L+ E+ + + + ++ +E ++ QEQ I+HL S + K+ LLQ+ Sbjct: 560 NQELRKALQQLQEELQNKSQQL----RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 615 Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555 F E + L A E L + I +K + + + + E+K+ + + Sbjct: 616 FRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA 675 Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS--YQNLRKTLEEQIS 613 V +++ D+ + L++ S N + + K LE + LS QNL+ EE + Sbjct: 676 VRERDHDL-----ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730 Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673 + R ++E S+ L L + N+ +VE S L K ++ +EL Q Sbjct: 731 KFSRWQKEQESIIQQ----LQTSLHDRNK-EVEDLSATLLCKLGPGQSEIAEELCQRLQR 785 Query: 674 LKKTIFDL 681 ++ + DL Sbjct: 786 KERMLQDL 793 Score = 69.7 bits (169), Expect = 2e-11 Identities = 144/715 (20%), Positives = 294/715 (41%), Gaps = 125/715 (17%) Query: 26 VPDDLDGINPNAGLGNGLLPNVSEETVSP------TRARNMKDFENQITELKKENFNLKL 79 V L G P + +G+ ++ P + + D + +L ++ L++ Sbjct: 315 VKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRV 374 Query: 80 RIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGG 139 + E QQ+ + ++T I + +S ELQE+ Q +K ++ Sbjct: 375 QPMTEELLKQQKLNS-----HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMS 429 Query: 140 SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKL 199 E++ +E ++K+ +++L ++ + + + E E+ + E + +L L Sbjct: 430 YELKCAQESSQKQDGTIQNL--------KETLKSRERETEELYQVIEGQNDTMAKLREML 481 Query: 200 --SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL----KEEKSQMACPDEN 253 S++ ++H + ++ + +L+ +L + IQ L ++++ Q+A + Sbjct: 482 HQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQC 538 Query: 254 VSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIAT---EK 310 V E A E E++ EA+ +Q+ R + +Q L+E+L+ K +++ EK Sbjct: 539 VQFVE------AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQLRAWEAEK 588 Query: 311 KNSLK-RDKAIQGLTMALKSKEKKVEEL--------NSE---------IEKLSAAFAKAR 352 N ++ +++ IQ L +L KE+ ++E NS+ +EKL Sbjct: 589 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648 Query: 353 EALQKAQTQEFQGSEDYETALS-----------GKEALSAALRSQNLTKSTENHRLRRS- 400 AL++A ++F E+ E L E L L S T + LR Sbjct: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708 Query: 401 --IKKITQELSDLQQERERLEKDLEEAHREKS----KGDCTIRDLRNEVEKLR------- 447 +++++ +LQ +E +E +E+ + ++ D EVE L Sbjct: 709 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 768 Query: 448 --------NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499 E+ +R + E + LLS+ NK++ E I+ L +S + ++ Q EK Sbjct: 769 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 828 Query: 500 DLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553 ++ ++++N L A L S+ I+ + + P G K+ Q S Sbjct: 829 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG---CLGKQTDQGS----- 880 Query: 554 IQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612 +Q+ +D T L + +E SI + +L+ + L K+L +E++ Sbjct: 881 MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKEL-----------SNAKEEL 925 Query: 613 SEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667 + ++E ES S S +++ EE QV+ E L + + L+K+L Sbjct: 926 ELMAKKERESQMELSALQSMMAVQEEE---LQVQAADMESLTRNIQIKEDLIKDL 977 Score = 43.1 bits (100), Expect = 0.002 Identities = 62/290 (21%), Positives = 115/290 (39%), Gaps = 47/290 (16%) Query: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS-- 1365 L L+ L+ S +E++ EL + + ED L + + P + E L+ +ET+ Sbjct: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR-VQPMTEELLKQQKLNSHETTIT 395 Query: 1366 ----EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421 S + Q++ +TE T N Q+ L E E++ ++ ++ T + L++ Sbjct: 396 QQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 451 Query: 1422 QL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNAML 1466 L ER+ E ++G A E LH S ++H + A L + L Sbjct: 452 TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL 511 Query: 1467 IKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKEEN 1505 + QK +R ES +K S +H Q ++++ Sbjct: 512 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 571 Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555 E LQ + + + E+R Q + + + ++QLL + +LLQ Sbjct: 572 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 621 Score = 36.2 bits (82), Expect = 0.30 Identities = 81/401 (20%), Positives = 156/401 (38%), Gaps = 48/401 (11%) Query: 1226 EIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELL 1285 E+ +LQ + DL VQ EL +QQ + H + + ++ + +E + Sbjct: 354 ELSDLQELWDDLCEDYLPLRVQPMTEELL--KQQKLNSHETTITQQSVSDSHLAELQEKI 411 Query: 1286 QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQH 1345 Q ++ + QE+LN+ + L+ ++ + K G N + L R E YQ Sbjct: 412 QQTEATNKI---LQEKLNEMSYELKCAQES--SQKQDGTIQNLKETLKSRERETEELYQV 466 Query: 1346 LLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTL 1405 + ++ +T K Q Q + + + Q L++ +++ Sbjct: 467 IEGQN------------DTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD----LQSA 510 Query: 1406 RKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM 1465 + I+ +++ +Q ERQ ++ Q + A+ E S E + K NQ L Sbjct: 511 LFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHE--SEQQKEASW--KHNQELRKA 566 Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQRE-YASVKEENERLQKEGSEKERHNQQLIQ 1524 L +L+E L K+ L + E Y ++ + + +Q H +QL+Q Sbjct: 567 L-----------QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-HKEQLLQ 614 Query: 1525 EVRCSGQELSRVQEEVKLRQQLLSQ-----NDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579 E R Q + ++ + LL + +DK + R + + L+E+ + LR Sbjct: 615 EFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRL 674 Query: 1580 YPMESDNSFDLFD---SSQAVTPKSVSETPPLSGNDTDSLS 1617 E D+ + SS T +S+ G + + LS Sbjct: 675 AVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLS 715 Score = 36.2 bits (82), Expect = 0.30 Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%) Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249 L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S + Sbjct: 574 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 631 Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309 A E+ L++ RQ ++ A E +A D + E +++L Q + Sbjct: 632 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 676 Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359 + LE+L S M + L+ +E+ + T Q+L L E E S Sbjct: 677 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 736 Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395 + E+ + + ++ E E S + QDLL Sbjct: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796 Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440 +EH EI+ L + R +ES EKL + L + SE ++ G S+ + Sbjct: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856 Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494 S + +T ++ +Q +M I D K S+ R T+ ++ L Sbjct: 857 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 914 Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554 ++E ++ KEE E + K+ E + L + +EL +++ + + + L+ Sbjct: 915 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 974 Query: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576 + L+++L A E+L +E LR+ Sbjct: 975 KDLQMQLVDPEDIPAMERLTQEVLLLRE 1002 >gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] Length = 1979 Score = 100 bits (249), Expect = 1e-20 Identities = 310/1622 (19%), Positives = 654/1622 (40%), Gaps = 278/1622 (17%) Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRE- 116 + M+ E++I ++ K+ + + L R Q++ + I + LK+E L+ Sbjct: 306 KKMEQLEDKIKDINKKLSSAENDRDILR-REQEQLNVEKRQIMEECENLKLECSKLQPSA 364 Query: 117 ------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----------- 159 + E+E++L +++ E +Q+ DA ++ ++ L Sbjct: 365 VKQSDTMTEKERILAQSASVEEVF------RLQQALSDAENEIMRLSSLNQDNSLAEDNL 418 Query: 160 -LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE 218 L RI +LEK+ + E E E + +L L+L ++ +K D+++ Sbjct: 419 KLKMRIEVLEKEKSLLSQEKE------ELQMSL-LKLNNEYEVIKSTATRDISL------ 465 Query: 219 KDRLIEELKLSLKSKEA-LIQCLKEEKSQMACPDE----NVSSGELRGLCAAPREEKERE 273 D + +L+L+L++KE L Q + E+++ +A +E N + + L +++ E Sbjct: 466 -DSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524 Query: 274 TEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKK 333 ++ + +++ N ++R+ LE+D + +E+ +K+ ++ + A+ L + + E K Sbjct: 525 GDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584 Query: 334 VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT-KST 392 VE L ++ K + ++ + + +E + E + E + + + N K T Sbjct: 585 VENLVDQLNKSQESNVSIQK--ENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642 Query: 393 ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE---------- 442 ++ + Q LS+L+Q E L+K + E K D+R++ Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ 702 Query: 443 --------VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ 494 VE L+ E E E + K LL E+NK E+ I+ L+ + N LQ Sbjct: 703 LSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANK----YEKTIEELSNARNLNTSALQ 758 Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554 +E +++ Q+ +D+E+ E+ + + S ++Q ++L Sbjct: 759 LEHEHLIKLNQK-------KDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ----KQLT 807 Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF-ALRKQLEQDVLSYQNLRKTLEEQIS 613 Q++ K++ ++ L+E S LQ EL+K ALRK + LR+T+EE+ Sbjct: 808 QLINKKE----IFIEKLKERSS--KLQEELDKYSQALRKN--------EILRQTIEEKDR 853 Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673 + +EE+ L + L EE +R + + V++L V +L T +H Sbjct: 854 SLGSMKEENNHLQEE----LERLREEQSR--TAPVADPKTLDSVTELASEVSQLNTIKEH 907 Query: 674 LKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSN 733 L++ I + N +L + Q + K++ D + + +++N Q + + Sbjct: 908 LEEEIKHHQKIIEDQNQSKMQLLQSLQEQ----KKEMDEFRY-QHEQMNATHTQLFLEKD 962 Query: 734 EIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRP 793 E +K L K + H E + D + +E +L +EK L Sbjct: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNS---DIFQETKVQSLNIENGSEKHDLSKAETE 1019 Query: 794 DLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQK-GELVHFVQTNSFSKPHDELKLS 852 L+K ++E L L E+ +S L + ++ K + G+L +Q E++ + Sbjct: 1020 RLVKGIKERELEIKLLNEKNIS---LTKQIDQLSKDEVGKLTQIIQQKDL-----EIQ-A 1070 Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGD-LLRFKHEATREAWEEKPINTALSAEHRPEN 911 A++ V +Q A E + + +E TRE N+ L E+ + Sbjct: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRE-------NSHLKTEYH-KM 1122 Query: 912 LHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQ---- 967 + V +AAL+ L + + + ++ N+ R+ +++ SQ Sbjct: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQT 1182 Query: 968 ---ILELQGELKEFKTCNKQLHQKLI-----LAEAVMEGRPTPDKTLLNAQPPVGAAYQD 1019 +L+ E N ++L+ L + V + + + Q ++ Sbjct: 1183 LLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQ---NMQHES 1239 Query: 1020 SPGEQKGIKTTSSVWRDKEMDSDQQ-------RSYEID------------------SEIC 1054 + +++ + + V D + +S Q +SYE + ++C Sbjct: 1240 AQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLC 1299 Query: 1055 PPDDLASLPSCKENPEDVLSP-TSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113 DL D++SP S A+ L+ +S + S +SE + S +E L+ Sbjct: 1300 NTKDLLL------GKLDIISPQLSSASLLTPQSAECLRAS-----KSEVL--SESSELLQ 1346 Query: 1114 QKIHDLETELEGYQNFIFQLQKHS-QCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS 1172 Q++ +L L+ I LQ+++ + S++I A L + ++ E T S Sbjct: 1347 QELEELRKSLQEKDATIRTLQENNHRLSDSI--------AATSELERKEH-----EQTDS 1393 Query: 1173 SLHQVRYVKHV---------KILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223 + Q++ + V ++ + +++ S EN ++ E E Q NL ++ Sbjct: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSN--ENFTNKVNENELLRQAVTNLKERI 1451 Query: 1224 F---SEIHNLQNKFRDL------SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHM 1274 +I L+ + + Y +L ++ + + R++ + H M Sbjct: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS--------M 1503 Query: 1275 NTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL-----------EKLFLNGKSVG 1323 AFE+LL+ + +G +LNQ ++ + +++ L K Sbjct: 1504 KEKALAFEQLLKEKE------QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQ 1557 Query: 1324 VEMNT--QNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381 +E NT QNE+ +++ + Q L E +H L ++ + + + ++ + Sbjct: 1558 ME-NTALQNEVQRLRDKEFRSNQEL-----ERLRNHLLESEDSYTREALAAEDREAKLRK 1611 Query: 1382 KTSVMVNSF-SQDLLMEHIQ-----EIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGST 1435 K +V+ S ME+ ++ +L+++L K ++ QL + Q + Sbjct: 1612 KVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671 Query: 1436 SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495 S+ ++L + +++ +A+ + ++ + E K E+L K +SL+ Sbjct: 1672 SL--------ANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL 1723 Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555 E + + RL ++ KE +++ ++ + +LRQ++L K L Sbjct: 1724 DEANAALDSASRLTEQLDVKE--------------EQIEELKRQNELRQEMLDDVQKKLM 1769 Query: 1556 SL 1557 SL Sbjct: 1770 SL 1771 Score = 93.6 bits (231), Expect = 2e-18 Identities = 326/1656 (19%), Positives = 634/1656 (38%), Gaps = 288/1656 (17%) Query: 43 LLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQ-QEFHGPTEHI-Y 100 +L +EE + K+ E L+ EN LK LEE+ + E + Y Sbjct: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSY 96 Query: 101 KTNIELK-VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL 159 + ++ K VE+ LK + L+K A +S+ G + Sbjct: 97 RNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSA 156 Query: 160 LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEK 219 + D+ ++Q E+ + RLES++ + H + A D Sbjct: 157 FHDDDMDFG-DIISSQQEINRLSNEVS-------RLESEVGHWR--HIAQTSKAQGTDNS 206 Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM 279 D+ E KL + +I+ LK+ +SQ ++ S +++ TE ++ Sbjct: 207 DQS-EICKL-----QNIIKELKQNRSQEIDDHQHEMS-------VLQNAHQQKLTEISR- 252 Query: 280 EHQKERNSFEERIQALEEDLREK-EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELN 338 H++E + +EERI+ LE L++ I T+ + K IQ L + KK+E+L Sbjct: 253 RHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLE 312 Query: 339 SEIEKLSAAFAKA---REALQKAQTQ----EFQGSEDYETALSGKEALSAALRSQNLTKS 391 +I+ ++ + A R+ L++ Q Q + Q E+ E L + Q+ T + Sbjct: 313 DKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMT 372 Query: 392 TENHRLRRS-----IKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446 + L +S + ++ Q LSD + E RL +++ S + ++ K+ Sbjct: 373 EKERILAQSASVEEVFRLQQALSDAENEIMRLSS----LNQDNSLAEDNLK------LKM 422 Query: 447 RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ------------ 494 R EV E+EK++ ++ K L S KL+N+ +VIK ST +D+ L Sbjct: 423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK----STATRDISLDSELHDLRLNLEA 478 Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEG------LITEKCSSQQPPGSKTIFSKEKKQSS 548 K E + + ++ + E+L+ +++ LI ++ S QQ G +I SK K+ + Sbjct: 479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGD-SIISKLKQDLN 537 Query: 549 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608 D ++ + L+ ++ D L + K+ L L+ Q L + Sbjct: 538 DEKKRVHQLEDDK------------MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585 Query: 609 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQ-EELKKKVSDLIQLVKEL 667 E + ++ + +E + + +++ N EH Q EE ++ + +L++ L Sbjct: 586 ENLVDQLNKSQESN------------VSIQKENLELKEHIRQNEEELSRIRN--ELMQSL 631 Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727 D+ + F D L + E+ K++ ++ ++ D Sbjct: 632 NQDSN----------------SNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDV 675 Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNE-KAT 786 ++ ++ C++ +RH ++ +C + LE+ + L E +A Sbjct: 676 KMENEKLVL------ACED--VRH---QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAE 724 Query: 787 L------LLESRPDLLKVVRELLLGQLFLTEQ-EVSGEHLDGKTEKTPKQKGELVHFVQT 839 L LLE K + EL + T ++ EHL +K + EL ++ Sbjct: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784 Query: 840 --NSFSKPHDELKLSCE-----AQLVKAGEVPKVGLKDAS--VQTVATEGDLLRFKHEAT 890 + D L S E QL+ E+ LK+ S +Q + K+E Sbjct: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844 Query: 891 REAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGN 950 R+ EEK + E EN H Q L L RE + P+ Sbjct: 845 RQTIEEKDRSLGSMKE---ENNH----LQEELERL-----REEQSRTAPVAD-------- 884 Query: 951 MYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNA- 1009 P T + VT+L S++ +L T + L +++ + ++E + LL + Sbjct: 885 ----PKTLDSVTELASEVSQLN-------TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL 933 Query: 1010 --QPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKE 1067 Q ++ + T + +D+E+ S Q+ +I +++ E Sbjct: 934 QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL------------HE 981 Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127 +D+ + S + +K Q +++ + ++ + ETE L + I + E E++ Sbjct: 982 ERQDIQTDNS-DIFQETKVQ---SLNIENGSEKHDLSKA-ETERLVKGIKERELEIKLLN 1036 Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187 L K D LSK + G L Q+ K ++I Sbjct: 1037 EKNISLTKQI-----------------DQLSKDEVGK---------LTQIIQQKDLEIQA 1070 Query: 1188 PLAPEMIDSRVLENLKQQLEEQEYKLQKEQ-----NLNMQLFSEIHNLQNKFRDLSPPRY 1242 A S + + Q + Q Y +++E+ N + S + +K D+ + Sbjct: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 1130 Query: 1243 DSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKA-----------FEELLQASDVD 1291 +L++ Q L + G + + Q+++ +I+ + LL Sbjct: 1131 AALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTS 1190 Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVG--------VEMNTQNELMERIEEDNLTY 1343 E NQ ELL++ +KL K + N Q+E + EE + Sbjct: 1191 STGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ 1250 Query: 1344 QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQ-----DLLMEH 1398 +L +S S DY +S+ + K N ++ + + +S Q DLL+ Sbjct: 1251 AQVLVDSDNNSKLQV--DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308 Query: 1399 I---------------QEIRTLRKRLEESI-KTNEKLRKQLERQGSEFVQGSTSI----- 1437 + Q LR E + +++E L+++LE + +I Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQE 1368 Query: 1438 --------FASGSEL----HSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKL---RE 1482 A+ SEL H SEI L+++ L +L + + ++D+L E Sbjct: 1369 NNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNE 1428 Query: 1483 SLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKL 1542 + + K E L++ ++KE L+ + + + N+++++ R E +QE Sbjct: 1429 NFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK 1488 Query: 1543 RQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGD 1578 +L + + S++ + A+E+L +E + + G+ Sbjct: 1489 FSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGE 1524 Score = 74.7 bits (182), Expect = 8e-13 Identities = 143/767 (18%), Positives = 312/767 (40%), Gaps = 146/767 (19%) Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT------N 103 E ++ T + + + +I L+K +K +++ EER Q+ I++ N Sbjct: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH--EER--QDIQTDNSDIFQETKVQSLN 1003 Query: 104 IE--------LKVEVESLKRELQERE---QLL----IKASKAVESLAEAGGSEIQRVKED 148 IE K E E L + ++ERE +LL I +K ++ L++ ++ ++ + Sbjct: 1004 IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQ 1063 Query: 149 ARKKVQQVEDLL-----TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK 203 ++Q + + T+ ++ L++ + A E EK FA + L+++ +M Sbjct: 1064 KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM 1123 Query: 204 KMHEG-DLAMALVLDEKDRL---------------IEELKLSLKSKEALIQCLKEEKSQM 247 + + A+ + DE +L I+ L ++ K+ I L ++ + Sbjct: 1124 DIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTL 1183 Query: 248 ACPDENVSSG-ELRGLCAAPREE--KERET---EAAQMEHQKER-----NSFEERIQALE 296 + S+G E G+ + EE +ER+ + +ME K++ + + L+ Sbjct: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243 Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356 E+L + + ++ + N+ K GL + + E K++ E+ ++ + Q Sbjct: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIG------Q 1297 Query: 357 KAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415 T++ L GK + +S L S +L LR S ++ E S+L Sbjct: 1298 LCNTKDL---------LLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL---- 1344 Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ 475 L+++LEE + + D TIR L+ +L + + + SE +K H Q Sbjct: 1345 --LQQELEELRKSLQEKDATIRTLQENNHRLSDSI------------AATSELERKEHEQ 1390 Query: 476 -EQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAED----------------LEL 518 + IK L E ++DVL + EKDL + ++ L+++ + L Sbjct: 1391 TDSEIKQLKE---KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL 1447 Query: 519 RSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL------IQVLKKEQDIYTHLVKS-- 570 + LI E + ++ I + + ++Y+ L ++ +E++ H +K Sbjct: 1448 KERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKA 1507 Query: 571 ------LQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---------KTLEEQI--S 613 L+E + ELN++ K +++ + +Q R K +E + Sbjct: 1508 LAFEQLLKEKE--QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565 Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673 E++R ++ F + + LE + + E + E+ + K+ + +++E + + Sbjct: 1566 EVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSN 1625 Query: 674 LKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 + + + + + EQ +++ + DE +++ E Sbjct: 1626 AMENASHQASVQVE--------SLQEQLNVVSKQRDETALQLSVSQE 1664 Score = 64.3 bits (155), Expect = 1e-09 Identities = 124/674 (18%), Positives = 269/674 (39%), Gaps = 86/674 (12%) Query: 954 LPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPV 1013 L A ++ + Q S+ L E++E N++ + +IL + + + ++++ Sbjct: 476 LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK-- 533 Query: 1014 GAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVL 1073 QD E+K + D + D Q+ I SE+ L L K+ ED + Sbjct: 534 ----QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVA----LNDLHLTKQKLEDKV 585 Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQL 1133 V + Q +++ E LK+ I E EL +N + Q Sbjct: 586 ENL---------------VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS 630 Query: 1134 QKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS-----------------SLHQ 1176 S T+L E L + N S+ E++ + + Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQ--NLSELEQLNENLKKVAFDVKMENEKLVLACED 688 Query: 1177 VRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRD 1236 VR+ + G + + ++E LK + E E +L + +L E + + + Sbjct: 689 VRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK---RLLEEANKYEKTIEE 745 Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE 1296 LS AR L+ Q++ H I + ++ M I ++ ++ D D+ + Sbjct: 746 LS----------NARNLNTSALQLEHEHLIKLNQKKDME--IAELKKNIEQMDTDH---K 790 Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEM--NTQNELMERIEEDN--LTYQHLLPESPE 1352 ++ L+ E ++L +L +N K + +E ++L E +++ + L +L ++ E Sbjct: 791 ETKDVLSSSLEEQKQLTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE 849 Query: 1353 PSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLME---HIQEIRTLRKRL 1409 +L + ++ E +T+ + + + D + E + ++ T+++ L Sbjct: 850 EK-DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHL 908 Query: 1410 EESIKTNEKL--------------RKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFL 1455 EE IK ++K+ ++ +++ EF + A+ ++L EI L Sbjct: 909 EEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 968 Query: 1456 RKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEK 1515 +K + + L + +D Q +N + + +++++E+ ++ K E ERL K E+ Sbjct: 969 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKER 1028 Query: 1516 ERHNQQLIQEVRCSGQELSRV-QEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574 E + L ++ +++ ++ ++EV Q++ Q D +Q+L + + + Sbjct: 1029 ELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQ 1088 Query: 1575 RDGDKYPMESDNSF 1588 + Y ME + F Sbjct: 1089 QQLQAYAMEREKVF 1102 Score = 53.5 bits (127), Expect = 2e-06 Identities = 152/780 (19%), Positives = 301/780 (38%), Gaps = 133/780 (17%) Query: 1099 QSESINTSNETEYLKQKIHDLETELEGYQN---FIFQLQKHSQCSEAIITVLCGTEGAQD 1155 Q E + ++ + E L+ KI D+ +L +N + + Q+ + I C + Sbjct: 298 QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLEC 357 Query: 1156 GLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQK 1215 +P + MT + +IL A + L+Q L + E ++ + Sbjct: 358 SKLQPSAVKQSDTMT----------EKERILAQSA----SVEEVFRLQQALSDAENEIMR 403 Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGI--------- 1266 +LN NL+ K R + SL+ + EL + ++ + + + Sbjct: 404 LSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDI 463 Query: 1267 ------------CVISRQHMN-------TMIKAFEEL----LQASDVDYCVAEGFQEQLN 1303 Q +N T+I EEL +A+ + + +Q N Sbjct: 464 SLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQN 523 Query: 1304 QCAELLEKLEKLFLNGK-----------SVGVEMNTQNELMERIEEDNLTYQHLLPESPE 1352 + ++ KL++ + K + E++ Q E + + E L HL + E Sbjct: 524 EGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQ-SEVALNDLHLTKQKLE 582 Query: 1353 PSASHALSDYETSEKSFFS--------RDQKQDNETEKTSV---MVNSFSQD-------- 1393 + + S++S S ++ + NE E + + ++ S +QD Sbjct: 583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642 Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRK---QLERQGSEFVQGSTSI-------FASGSE 1443 LL E E+R L++ L E + NE L+K ++ + + V + A ++ Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ 702 Query: 1444 LHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDK----LRESLSRKTVSLEHLQREYA 1499 L + + L+ + + A L + +E +K + E + + ++ LQ E+ Sbjct: 703 LSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHE 762 Query: 1500 SVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRV 1559 + + N++ E +E +++ +Q+ + + + LS EE K QL+++ + ++ L+ Sbjct: 763 HLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKE 822 Query: 1560 -ELKAYEKLDEEHRRLRDGD---KYPMESDNSFDLFDSSQAVTPKSV-------SETPPL 1608 K E+LD+ + LR + + E D S + + S T P+ Sbjct: 823 RSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPV 882 Query: 1609 SGNDTDSLSCDSGSSATSTPCVSRLVT-GHHLWASKNGRHVLGLIEDYE----ALLKQIS 1663 + D + DS + S VS+L T HL + +H +IED LL+ + Sbjct: 883 A----DPKTLDSVTELASE--VSQLNTIKEHL--EEEIKHHQKIIEDQNQSKMQLLQSLQ 934 Query: 1664 QGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWR 1723 + ++ + E Q ++ ++ +Q K L K + + T L E + ++ Sbjct: 935 EQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT---QLHEERQDIQTDNS 991 Query: 1724 VSLPEDGQCPLHCEQIGE----MKAEVTKLHKKLFEQ--------EKKLQNTMKLLQLSK 1771 E L+ E E KAE +L K + E+ EK + T ++ QLSK Sbjct: 992 DIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK 1051 Score = 31.6 bits (70), Expect = 7.3 Identities = 61/307 (19%), Positives = 126/307 (41%), Gaps = 43/307 (14%) Query: 1328 TQNELMERIEEDNLTYQHLLPES--PEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385 T++ LME EE + LP+S E A HA+ E D ++ +E + + Sbjct: 34 TKDMLMEGTEE----VEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQI 89 Query: 1386 MVNSFS-QDLLMEHIQEIRTLRKR---LEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441 S S ++ L + EI L+ R L++ + + + + ++S FA G Sbjct: 90 KQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYG 149 Query: 1442 SELHSSL--TSEIHF--LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL-QR 1496 H S ++ F + Q +N + + SR + + + + K ++ Q Sbjct: 150 ISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS 209 Query: 1497 EYASVKEENERLQKEGSEK------------ERHNQQLIQEVRCSGQELSRVQEEVKLRQ 1544 E ++ + L++ S++ H Q+L + R +ELS +E ++ + Sbjct: 210 EICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELE 269 Query: 1545 QLLSQN---------------DKLLQSLRVE-LKAYEKLDEEHRRLRDGDKYPMESDNSF 1588 LL Q K +Q L++E +++ +K+++ +++D +K ++N Sbjct: 270 NLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDR 329 Query: 1589 DLFDSSQ 1595 D+ Q Sbjct: 330 DILRREQ 336 Score = 31.6 bits (70), Expect = 7.3 Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 7/108 (6%) Query: 44 LPNVSEETVSPTRARNMKDFENQ---ITELKKENFNLKLRIYFLEERMQQEFHGPTEHIY 100 L V E +A + E Q I E KK NL+ ++ L+E + E + + Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLD-EANAALDSAS 1734 Query: 101 KTNIELKV---EVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRV 145 + +L V ++E LKR+ + R+++L K + SLA + ++ +V Sbjct: 1735 RLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782 >gi|114155142 nuclear pore complex-associated protein TPR [Homo sapiens] Length = 2363 Score = 100 bits (249), Expect = 1e-20 Identities = 168/750 (22%), Positives = 314/750 (41%), Gaps = 102/750 (13%) Query: 54 PTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESL 113 P+ ++ D +Q+ + +++ +LK R+ ++Q T N E +V E + Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV-TEEV 986 Query: 114 KRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTA 173 ++ ++ R + + +E E Q +++D R+ ++ +E L++ L+K +++ Sbjct: 987 RKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSE----LKKTLSS 1042 Query: 174 AQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233 Q E+++A T + + E K + ++ +++ EL L Sbjct: 1043 VQNEVQEALQRASTALSNEQQARRDCQEQAK---------IAVEAQNKYERELMLHAADV 1093 Query: 234 EALIQCLKEEKSQMACP----DENVSSGELRGL-CAAPREEKER--ETEAAQM-----EH 281 EAL Q KE+ S+MA +E E + L C A EE+ER + E ++ + Sbjct: 1094 EAL-QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDL 1152 Query: 282 QKERNSFEERIQALEEDLREKEREIATEKKN-SLKRDKAIQGLTMALKS---KEKKVEEL 337 +K+ ++I+ L + + +E N SL + Q + + +EK++ E Sbjct: 1153 EKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET 1212 Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTE---- 393 E+ ++ + + R L + + QE Q S + E A + A + + L K TE Sbjct: 1213 RFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA-QHEELMKKTETMNV 1271 Query: 394 ----NHRLRRSIKKITQELSDLQQERERLEKD---LEEAHREKSKGDCTIRDLRNEVE-- 444 N LR +++ Q+L +Q + +LE D L+EA+ E S+ ++ + +E Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEED 1331 Query: 445 ----KLRNE--VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498 K RN+ V++++ Y+ LLSE K++H + I+ LTE + + + N Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSE--KEVHTKR--IQQLTEEIGRLKAEIARSNA 1387 Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEK------------KQ 546 QN EDL + TEK + Q+ +K I +EK + Sbjct: 1388 SLTN--NQNLIQSLKEDLNK----VRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRY 1441 Query: 547 SSDYEELIQVLKKEQDIYTHLVKSLQES----DSINNLQAELNKIFALRKQLEQDVLSYQ 602 + YEEL K + QE + L+ LN+ K LE V + Sbjct: 1442 KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV---E 1498 Query: 603 NLRKTLEEQISEIRRREEESFSLYSD-----QTSYLSICLEENNRFQVEHFSQE------ 651 NL+KTL E+ +E R +E++ L S+ Q EE R Q+ ++ Sbjct: 1499 NLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIV 1558 Query: 652 ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDED 711 K K++ L + +L +N+ LK Q NG D+ + A K + Sbjct: 1559 AAKSKIAHLAGVKDQLTKENEELK-----------QRNGALDQQKDELDVRITALKSQYE 1607 Query: 712 TIKIGEDDEINFLSDQHLQQSNEIMKDLSK 741 + E+ ++HL+Q +E + +K Sbjct: 1608 GRISRLERELREHQERHLEQRDEPQEPSNK 1637 Score = 92.8 bits (229), Expect = 3e-18 Identities = 304/1658 (18%), Positives = 632/1658 (38%), Gaps = 212/1658 (12%) Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQ--EFHGPTEHIYKTNIELKVEVESLKR 115 + + + ++ +E +L+L + L +++ E + E NI ++ + K Sbjct: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118 Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175 EL+ ++ LI+ ++ + E +++R+ E ++ +L K L DV+ Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178 Query: 176 AELEKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKE 234 E E EK L + L+ E+K + LA+ EK I ELK +L++K+ Sbjct: 179 REKR-----LEQEKELLHSQNTWLNTELKTKTDELLALGR---EKGNEILELKCNLENKK 230 Query: 235 ALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKER--------- 285 + L+E+ + + +E++ + L +E KE++ + H + Sbjct: 231 EEVSRLEEQMNGLKTSNEHLQK-HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLY 289 Query: 286 NSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK-SKEKKVEELNSEIEKL 344 S + +A +L E+ K + + +KAIQ + ++ SK++ +E+ +I +L Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349 Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKI 404 A + L + + SE+ A+S A A + + K TE L + + Sbjct: 350 EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM-KLTE---LYNAYVET 405 Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL 464 +L + E +R+ K L+E +E ++ R E E+ + V +E K + Sbjct: 406 QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465 Query: 465 --LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522 L E K + Q V+ ++D + KDL Q ++ E E R Sbjct: 466 QRLQEDTDKANKQSSVL--------ERDNRRMEIQVKDLS---QQIRVLLMELEEARGNH 514 Query: 523 LIT-EKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQ 581 +I E+ SS S + S+ + EEL Q + Q + L + L E+ + Sbjct: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ---QNQRLLVAL-RELGETREREEQE 570 Query: 582 AELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRR--REEESFSLYSDQTSYLSICLEE 639 +KI L+ +LE + + LRK+ + Q+ + R+ + + + QT+ ++I L Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA 630 Query: 640 NNRFQV---------------------------EHFSQEELKKKVSDLIQLVKELYTDNQ 672 ++ V E + K++ ++ + K+ +N+ Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690 Query: 673 -----HLKKTIFDLSCMGFQGNGFPDRLA-STEQTELLASKEDEDTIKIGEDDEINFLSD 726 L+K ++ + Q +L ++++ E+L + +I E N Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750 Query: 727 QHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLL-APLFNEKA 785 Q+ +I+ +++ LR K++ + A +E + L L ++ Sbjct: 751 ATTQKQEQIINTMTQD------LRGANEKLAVAE-VRAENLKKEKEMLKLSEVRLSQQRE 803 Query: 786 TLLLESRPDLLKVV----------------RELLLGQLFLTEQEVSGEHLDGKTEKTPKQ 829 +LL E R L + ++ L Q+ E E+S HL K E +Q Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEIS--HLKKKLENEVEQ 861 Query: 830 KGEL-----VHFVQTNSFSKPHDELKLSCEAQLVKAGE---VPKVGLKDASVQTVATEGD 881 + L V + T L L+ + L A + K L + VQ VA++ Sbjct: 862 RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQ-VASQSS 920 Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLH--------GVPGWQAALLSLPGITNREA 933 K + + + + ++ E + +L V +QA + SL N+E Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980 Query: 934 KKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993 + + RL + E TQL+ +++E++ E +E + ++ E Sbjct: 981 Q-------VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRA------IE 1027 Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053 ++ + KTL + Q V A Q + T S + D +Q ++++ Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRA-------STALSNEQQARRDCQEQAKIAVEAQN 1080 Query: 1054 CPPDDL----ASLPSCKENPEDVLSPTSVATYLSSKSQP--SAKVSVMGTDQSESINTSN 1107 +L A + + + E V SV +L +Q S + + + + Sbjct: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140 Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167 E + DLE QN + Q + + +V G +G + +S + G E Sbjct: 1141 EVSKCVCRCEDLEK-----QNRLLHDQIEKLSDKVVASVKEGVQGPLN-VSLSEEGKSQE 1194 Query: 1168 EMT------------------FSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQ 1209 ++ + + +RY + V++L E+ DS E K Q+ + Sbjct: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254 Query: 1210 EYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQ---------RQQI 1260 +E + + + R+ L Q QA+ L+ ++ Sbjct: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314 Query: 1261 KDGHGICVISRQHMNTMIKAFEE-----LLQASDVDYCVAEGFQEQLNQ-------CAEL 1308 + G+ ++ + +K ++ + Q D D E +++ L++ +L Sbjct: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD---TEEYRKLLSEKEVHTKRIQQL 1371 Query: 1309 LEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368 E++ +L + L++ ++ED L E+ + + D + K+ Sbjct: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKED-LNKVRTEKETIQKDLDAKIIDIQEKVKT 1430 Query: 1369 FFS--------RDQKQDNETEKTSVMVNSF--SQDLLMEHI--QEIRTLRKRLEESIKTN 1416 + Q ++ + ++ VM S S D +H+ QE++ L++ L ++ + Sbjct: 1431 ITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS 1490 Query: 1417 EKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKE 1476 + L Q+E + T + E L SE+ LR+ Q + + ++ Sbjct: 1491 KSLESQVENLQKTLSEKETEA-RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK 1549 Query: 1477 NDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRV 1536 +K R+++ + HL + +ENE L++ ++ +L +VR + + Sbjct: 1550 EEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL--DVRITALKSQYE 1607 Query: 1537 QEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574 +L ++L ++ L+ + K+ E+ R++ Sbjct: 1608 GRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645 Score = 66.6 bits (161), Expect = 2e-10 Identities = 266/1374 (19%), Positives = 518/1374 (37%), Gaps = 219/1374 (15%) Query: 537 KTIFSKEKKQSSDYEELIQVLK--------KEQDIYTHLVKSLQESDSINNLQAELNKIF 588 K++ +K +K +D + I LK + + Y + K L S L E + Sbjct: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE--RLVNETRECQ 76 Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648 +LR +LE+ N K L E+ E+ ++ + ++ S T Sbjct: 77 SLRLELEK----LNNQLKALTEKNKELEIAQDRNIAIQSQFTR----------------- 115 Query: 649 SQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE 708 ++EEL+ + DLI+ + L + ++L + + L+ + N L Q +L + Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGEL----QLKLDELQA 171 Query: 709 DEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCL 768 + ++K E + L+Q E++ +N +L +TE K + D A G Sbjct: 172 SDVSVKYRE---------KRLEQEKELLHS------QNTWL-NTELK-TKTDELLALGRE 214 Query: 769 EEGAFINLLAPLFNEKATLL-LESRPDLLKVVRELLLGQL--FLTEQEVSGEHLDGKTEK 825 + + L L N+K + LE + + LK E L + LT+ + + E EK Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274 Query: 826 TPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRF 885 + H +N + D+ + +L +A E LK+A A + LL Sbjct: 275 FHNELN--AHIKLSNLYKSAADDSEAKSN-ELTRAVEELHKLLKEAGEANKAIQDHLLEV 331 Query: 886 KHEATREAWEEKPINTALSAEHRPEN---LHGVPGWQAALLSLPGITNREAKKSRLPILI 942 E +++ E++ + E EN L + A+LS + + + ++ Sbjct: 332 --EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389 Query: 943 KPSRSLGNMYRLPAT-------------------QEVVTQLQSQILELQGELKEFKTCNK 983 KP L +Y E+V +++++ L+ + +E++ K Sbjct: 390 KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQK 449 Query: 984 QLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ 1043 + + E M+ + A +D+ + +K S R M+ ++ Sbjct: 450 AVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509 Query: 1044 QRSYEI--DSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSE 1101 R + D E+ D +S +V+S V+ + Q + ++ + Sbjct: 510 ARGNHVIRDEEVSSADISSS--------SEVISQHLVSYRNIEELQQQNQRLLVALRELG 561 Query: 1102 SINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIIT-----------VLCGT 1150 E E KI +L+ +LE + QL+K Q ++ +L T Sbjct: 562 ETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621 Query: 1151 EGAQDGL-----------SKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVL 1199 G L S PK S + T S+ V ++ + + A + Sbjct: 622 TGVAIPLHASSLDDVSLASTPKRPSTSQ--TVSTPAPVPVIESTEAIEAKAALKQLQEIF 679 Query: 1200 ENLKQQLEEQEYKLQKEQNLNMQ-LFSEIHNLQNKFR---DLSPPRYDSL---VQSQARE 1252 EN K++ E E K+Q EQ +Q +++ + K D + RY+ L V+ RE Sbjct: 680 ENYKKEKAENE-KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738 Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312 ++ ++ + Q +NTM + L+ ++ VAE E L + E+L+ Sbjct: 739 ITSLHERNQKLTATTQKQEQIINTMTQD----LRGANEKLAVAEVRAENLKKEKEMLKLS 794 Query: 1313 E-KLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFS 1371 E +L +S+ E QN L+ ++ T Q +L S ET K Sbjct: 795 EVRLSQQRESLLAEQRGQNLLLTNLQ----TIQGILERS------------ETETK---- 834 Query: 1372 RDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQ---GS 1428 Q+ ++ EK +EH EI L+K+LE ++ L + L+ Q Sbjct: 835 --QRLSSQIEK-------------LEH--EISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877 Query: 1429 EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM----------------------L 1466 + T++ + EL + EI L++ + L Sbjct: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937 Query: 1467 IKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE-NERLQ-------------KEG 1512 + R +++ + L+E L T ++E Q S++E N+ Q KE Sbjct: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997 Query: 1513 SEKERHNQQLIQEVRCSGQEL-SRVQEEVKLRQQLLSQNDKLLQSLRVEL-----KAYEK 1566 +E + ++ + EV QEL + ++ +Q LS+ K L S++ E+ +A Sbjct: 998 AEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA 1057 Query: 1567 LDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATS 1626 L E + RD + + + + ++ + V + S T+ Sbjct: 1058 LSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETT 1117 Query: 1627 TPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQE 1686 S+L+ W + R + + + + + RLL + + + ++ +E Sbjct: 1118 QKAESQLLECKASWEERE-RMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE 1176 Query: 1687 LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEV 1746 G +GP LS+ S L R ++ + + +++ ++ E+ Sbjct: 1177 -GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLEREL 1235 Query: 1747 TKLHKKLFEQEKKLQNTMKLL----QLSKRQEKVIFDQLVVTHKILRKARGNLE 1796 +L L + +K+Q T K + +L K+ E + + ++ T+K+LR+ + LE Sbjct: 1236 QELQDSLNAEREKVQVTAKTMAQHEELMKKTETM--NVVMETNKMLREEKERLE 1287 Score = 60.5 bits (145), Expect = 1e-08 Identities = 88/423 (20%), Positives = 188/423 (44%), Gaps = 35/423 (8%) Query: 46 NVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEE--RMQQEFHGPTEHIYKTN 103 N E V T A+ M E + + + N ++ EE R++Q+ + K Sbjct: 1243 NAEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE 1301 Query: 104 IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDAR-------KKVQQV 156 +++ + ++ EL E+ +L K +E + + Q + + +K+ Sbjct: 1302 LDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE 1360 Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM---KKMHEGDLAMA 213 +++ TKRI L +++ +AE+ ++ A + L L+ L+++ K+ + DL Sbjct: 1361 KEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK 1420 Query: 214 LV-LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER 272 ++ + EK + I ++K + + + LK ++ ++ SSG+ + + +E +E Sbjct: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ-SSGDHQEQHVSVQEMQEL 1479 Query: 273 ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEK 332 + Q E + + S E +++ L++ L EKE E ++ +++ + L L+ + Sbjct: 1480 KETLNQAETKSK--SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537 Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392 + E+L +I + KA A K++ G +D T KE R+ L + Sbjct: 1538 QEEQLRQQITEKEEKTRKAIVA-AKSKIAHLAGVKDQLT----KENEELKQRNGALDQQK 1592 Query: 393 ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE 452 + +R IT S + RLE++L E H+E+ + R+E ++ N+V E Sbjct: 1593 DELDVR-----ITALKSQYEGRISRLERELRE-HQERH------LEQRDEPQEPSNKVPE 1640 Query: 453 REK 455 +++ Sbjct: 1641 QQR 1643 Score = 59.7 bits (143), Expect = 3e-08 Identities = 232/1269 (18%), Positives = 477/1269 (37%), Gaps = 177/1269 (13%) Query: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390 EK + + SEI+ L K R K ++++ + + S + ++ Q+L Sbjct: 26 EKFLADQQSEIDGL-----KGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRL 80 Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450 E +L +K +T++ +L+ ++R + R K + + RDL E+L E+ Sbjct: 81 ELE--KLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQEL 138 Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYL 510 L+E K+L+ + L ES K L K +E L Sbjct: 139 ------------EYLTEDVKRLNEK------LKESNTTKGELQLKLDE-----------L 169 Query: 511 MAAE-DLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVK 569 A++ ++ R + L EK + T + E K +D EL+ + +++ + L Sbjct: 170 QASDVSVKYREKRLEQEK---ELLHSQNTWLNTELKTKTD--ELLALGREKGNEILELK- 223 Query: 570 SLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQ 629 NL+ + ++ L +Q+ S ++L+K +E+ +++++ +E+ S+ Sbjct: 224 --------CNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275 Query: 630 TSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGN 689 + L+ ++ +N ++ + ++ + K ++L + V+EL+ + LK+ G Sbjct: 276 HNELNAHIKLSNLYK---SAADDSEAKSNELTRAVEELH---KLLKEA-------GEANK 322 Query: 690 GFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYL 749 D L EQ++ E E KIG ++ L+ +N+++ + K L Sbjct: 323 AIQDHLLEVEQSK--DQMEKEMLEKIGR-------LEKELENANDLLSATKR---KGAIL 370 Query: 750 RHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFL 809 E A ++ G + L + E LL + + ++ + L + Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL---DEIV 427 Query: 810 TEQEVSGEHLDGKTEKTPK-QKGELVHFVQTNSFSKPHDELKLSCE------AQLVKAGE 862 E E L + E+ + QK V+ K L+ + + L + Sbjct: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNR 487 Query: 863 VPKVGLKDAS--VQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQA 920 ++ +KD S ++ + E + R H +E+ + +S+ + H Sbjct: 488 RMEIQVKDLSQQIRVLLMELEEARGNHVIR----DEEVSSADISSSSEVISQH------- 536 Query: 921 ALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKT 980 L+S I + + RL + ++ T +T+LQ L+L+ L E + Sbjct: 537 -LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQ---LKLESALTELEQ 592 Query: 981 CNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMD 1040 K ++ L ++++ R D + G A P + S K Sbjct: 593 LRKSRQHQMQLVDSIVRQR---DMYRILLSQTTGVAI---PLHASSLDDVSLASTPKRPS 646 Query: 1041 SDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS--AKVSVMGTD 1098 + Q S + + + + +++ + K Q K+ TD Sbjct: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD 706 Query: 1099 -QSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQ--------CSEAIITVLCG 1149 +S++ S + ++ ++ L+ +EGY+ I L + +Q + I T+ Sbjct: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD 766 Query: 1150 TEGAQDGLSKPKNGSDG--EEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLE 1207 GA + L+ + ++ +E L +VR + + L LA + + +L NL+ Sbjct: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESL--LAEQRGQNLLLTNLQ---T 821 Query: 1208 EQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGIC 1267 Q + E +L S+I L+++ L + + Q +L Q + + Sbjct: 822 IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881 Query: 1268 VISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMN 1327 + H+NT +ELL+ + + A L + L + + S + Sbjct: 882 TETNLHLNT-----KELLKNAQ-------------KEIATLKQHLSNMEVQVASQSSQRT 923 Query: 1328 TQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMV 1387 + + + + D+L Q L E R + + E+ MV Sbjct: 924 GKGQPSNKEDVDDLVSQ--------------LRQTEEQVNDLKERLKTSTSNVEQYQAMV 969 Query: 1388 NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSS 1447 S + L E Q +RK +E +K + + + QLE++ E + EL Sbjct: 970 TSLEESLNKEK-QVTEEVRKNIEVRLKESAEFQTQLEKKLME-------VEKEKQELQDD 1021 Query: 1448 LTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER 1507 I + +Q L L ++++E+L R + +L + Q+ +E+ + Sbjct: 1022 KRRAIESMEQQLSELKKTL-------SSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074 Query: 1508 LQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKL 1567 + ++ ER +V +V + +RQ L K +S +E KA Sbjct: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK-AESQLLECKA--SW 1131 Query: 1568 DEEHRRLRD 1576 +E R L+D Sbjct: 1132 EERERMLKD 1140 Score = 50.8 bits (120), Expect = 1e-05 Identities = 137/748 (18%), Positives = 301/748 (40%), Gaps = 105/748 (14%) Query: 1058 DLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIH 1117 ++A+L N E + S ++ + K QPS K D + ++ +TE ++++ Sbjct: 900 EIATLKQHLSNME--VQVASQSSQRTGKGQPSNK-----EDVDDLVSQLRQTE---EQVN 949 Query: 1118 DLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQV 1177 DL+ L+ + + Q Q A++T L ++ L+K K ++ +V Sbjct: 950 DLKERLKTSTSNVEQYQ-------AMVTSL------EESLNKEKQVTEEVRKNI----EV 992 Query: 1178 RYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL--QKEQNLNMQLFSEIHNLQNKFR 1235 R + + L ++++ +E KQ+L++ + + EQ L+ +L + ++QN+ + Sbjct: 993 RLKESAEFQTQLEKKLME---VEKEKQELQDDKRRAIESMEQQLS-ELKKTLSSVQNEVQ 1048 Query: 1236 DLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVA 1295 + +Q + LS ++Q +D I+ + N + E +L A+DV+ Sbjct: 1049 EA--------LQRASTALSNEQQARRDCQEQAKIAVEAQNKYER--ELMLHAADVE--AL 1096 Query: 1296 EGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355 + +EQ+++ A + + LE+ +S +E E ER+ +D ++ E E Sbjct: 1097 QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQN 1156 Query: 1356 SHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLE----- 1410 E + ++ S+ SQ+ ++E ++ IR ++ E Sbjct: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV 1216 Query: 1411 ---ESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLI 1467 ES++ +++ + LER+ E +Q S + ++ + ++ L K+ + +N ++ Sbjct: 1217 AQVESLRYRQRV-ELLERELQE-LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVM- 1273 Query: 1468 KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVR 1527 + ++ ++E ++L + L + + L+ + ++E N L ++ + + L ++V+ Sbjct: 1274 ETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVK 1333 Query: 1528 ---CSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLR-DGDKYPME 1583 Q L Q++ + KLL V K ++L EE RL+ + + Sbjct: 1334 RWKARNQHLVSQQKDPDTEEYR-----KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNAS 1388 Query: 1584 SDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASK 1643 N+ +L S + K +E + D D+ D + V ++ Sbjct: 1389 LTNNQNLIQSLKEDLNKVRTEKETIQ-KDLDAKIIDIQEKVKTITQVKKI---------- 1437 Query: 1644 NGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSS 1703 GR E+ +A ++ ++T S QE L + ++ Sbjct: 1438 -GRRYKTQYEELKAQQDKV-----------METSAQSSGDHQEQHVSVQEMQELKETLNQ 1485 Query: 1704 VSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNT 1763 T +LE L+ + + E + E L ++ + + +L Sbjct: 1486 AETKSKSLESQVENLQ-----------------KTLSEKETEARNLQEQTVQLQSELSRL 1528 Query: 1764 MKLLQLSKRQEKVIFDQLVVTHKILRKA 1791 + LQ QE+ + Q+ + RKA Sbjct: 1529 RQDLQDRTTQEEQLRQQITEKEEKTRKA 1556 Score = 45.4 bits (106), Expect = 5e-04 Identities = 65/283 (22%), Positives = 125/283 (44%), Gaps = 42/283 (14%) Query: 411 LQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNK 470 LQQ ER E + + ++K + + D ++E++ L+ + + E +Y E K Sbjct: 5 LQQVLERTELN-KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQY----FEIEK 59 Query: 471 KL-HNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCS 529 +L H+QE+++ E + + + L+K N + + ++N L A+D + + T + Sbjct: 60 RLSHSQERLVNETRECQSLR-LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT-RTK 117 Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA 589 + + + ++ S + E L + +K+ L + L+ES N + EL Sbjct: 118 EELEAEKRDLIRTNERLSQELEYLTEDVKR-------LNEKLKES---NTTKGEL----- 162 Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQT-----------SYLSICLE 638 QL+ D L ++ E +R E+E L+S T L++ E Sbjct: 163 ---QLKLDELQASDVSVKYRE-----KRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214 Query: 639 ENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681 + N + E K++VS L + + L T N+HL+K + DL Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL 257 Score = 45.1 bits (105), Expect = 6e-04 Identities = 91/443 (20%), Positives = 161/443 (36%), Gaps = 95/443 (21%) Query: 1347 LPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVN---SFSQDLLMEHIQEIR 1403 LP+S + L+D ++ R +K E+E+ + S SQ+ L+ +E + Sbjct: 17 LPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQ 76 Query: 1404 TLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN 1463 +LR LE K N +L+ E+ E+ + +N A+ Sbjct: 77 SLRLELE---KLNNQLKALTEKN-----------------------KELEIAQDRNIAIQ 110 Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLI 1523 + + + + E L + R + LE+L + VK NE+L++ + K Sbjct: 111 SQFTRTKEELEAEKRDLIRTNERLSQELEYLTED---VKRLNEKLKESNTTKG------- 160 Query: 1524 QEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQS----LRVELKAYEKLDEEHRRLRDGDK 1579 E++ EL VK R++ L Q +LL S L ELK K DE R+ Sbjct: 161 -ELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT--KTDELLALGRE--- 214 Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639 GN+ L C+ + + + G Sbjct: 215 -----------------------------KGNEILELKCNLENKKEEVSRLEEQMNG--- 242 Query: 1640 WASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSK 1699 + H+ +ED LK+ + Q + E A S L K Sbjct: 243 -LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN-----------LYK 290 Query: 1700 FVSSVSTAKLT-LEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTK-LHKKLFEQE 1757 + S AK L A L L + + + H ++ + K ++ K + +K+ E Sbjct: 291 SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE 350 Query: 1758 KKLQNTMKLLQLSKRQEKVIFDQ 1780 K+L+N LL +KR+ ++ ++ Sbjct: 351 KELENANDLLSATKRKGAILSEE 373 Score = 42.0 bits (97), Expect = 0.005 Identities = 77/371 (20%), Positives = 150/371 (40%), Gaps = 57/371 (15%) Query: 1268 VISRQHMNTMIKAFEELL------QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321 V+ R +N + K+ + L Q S++D + ++ + E ++L + + Sbjct: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67 Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381 + E L +E+ N + L ++ E + D + +S F+R K++ E E Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQ---DRNIAIQSQFTRT-KEELEAE 123 Query: 1382 KTSVMVNSFSQDLLMEHIQE-IRTLRKRLEESIKTNEKLRKQL-ERQGSEFVQGSTSIFA 1439 K ++ + +E++ E ++ L ++L+ES T +L+ +L E Q S+ Sbjct: 124 KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASD---------V 174 Query: 1440 SGSELHSSLTSEIHFLRKQNQALNAML-------IKGSRDKQKENDKLRESLSRKTVSLE 1492 S L E L QN LN L + R+K E +L+ +L K + Sbjct: 175 SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVS 234 Query: 1493 HLQREYASVKEENERLQK---------------EGSEKERHNQQLIQEVRCS-------- 1529 L+ + +K NE LQK + S +E+ + +L ++ S Sbjct: 235 RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294 Query: 1530 -----GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMES 1584 EL+R EE+ + + +K +Q +E++ K E L + E Sbjct: 295 DSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE-QSKDQMEKEMLEKIGRLEKEL 353 Query: 1585 DNSFDLFDSSQ 1595 +N+ DL +++ Sbjct: 354 ENANDLLSATK 364 >gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo sapiens] Length = 1983 Score = 98.6 bits (244), Expect = 5e-20 Identities = 137/611 (22%), Positives = 261/611 (42%), Gaps = 71/611 (11%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 EE V+ A + E++ TELKK+ +LKL + E+ Q TE+ K E Sbjct: 978 EEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQ-----ATENKVKNLTEEMA 1032 Query: 109 EVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL--LTKRILL 166 ++ L + ++ L +A + +A + + + + QQVEDL ++ Sbjct: 1033 ALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKK 1092 Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI--- 223 L D A+ +LE T+ A + + +L E K + +L+ + E ++L+ Sbjct: 1093 LRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQ 1152 Query: 224 ------------EELKLSLKSKEALIQCLKEEKSQMACPDENVSS--GELRGLCAAPREE 269 EEL+ L+++ A +++++++ A E +S E G A RE Sbjct: 1153 MQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREG 1212 Query: 270 -KERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328 ++RE E ++ + E + R +A LR K+ E A E + + L + Sbjct: 1213 CRKREAELGRLRRELEEAAL--RHEATVAALRRKQAEGAAE------LGEQVDSLQRVRQ 1264 Query: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388 EK+ EL E++ L+A E L +A+ + YE LS + L+ Q Sbjct: 1265 KLEKEKSELRMEVDDLAANV----ETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320 Query: 389 TKSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDC 434 ST+ RL+ ++++ L + + Q E L + LEE + KS Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380 Query: 435 TIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN-----QEQVIKHLTESTNQK 489 ++ LR++ + LR E +E E + + LLS++N ++ + I+ E K Sbjct: 1381 AVQALRHDCDLLR-EQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAK 1439 Query: 490 DVLLQKFNEKD--LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547 L + E + +E C + L L++E +E + + + + +KKQ Sbjct: 1440 KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE---SEDVTLELERATSAAAALDKKQR 1496 Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR-- 605 L + ++E+++ L + +ES + ++F LR E+ + + + L+ Sbjct: 1497 HLERALEERRRQEEEMQRELEAAQRESRGLG------TELFRLRHGHEEALEALETLKRE 1550 Query: 606 -KTLEEQISEI 615 K L+E+IS++ Sbjct: 1551 NKNLQEEISDL 1561 Score = 87.4 bits (215), Expect = 1e-16 Identities = 157/690 (22%), Positives = 290/690 (42%), Gaps = 96/690 (13%) Query: 43 LLPNVSEETVSPTRARNM-KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK 101 L NV T + A + + +E+Q++E K + +EE +Q T+ Sbjct: 1280 LAANVETLTRAKASAEKLCRTYEDQLSEAKIK----------VEELQRQLADASTQRG-- 1327 Query: 102 TNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKK----VQQVE 157 L+ E L R L+E+E L+ + S+ ++LA E++R E+ K V+ Sbjct: 1328 ---RLQTESGELSRLLEEKECLISQLSRG-KALAAQSLEELRRQLEEESKAKSALAHAVQ 1383 Query: 158 DLLTKRILLLEK--DVTAAQAELEKAFAGTETEKAL-RLRLESK-LSEMKKMHEGDLAMA 213 L LL E+ + AQAEL++ + E A R + E+ + +++ E +A Sbjct: 1384 ALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA 1443 Query: 214 LVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGEL----------RGLC 263 L L E + +E S E L+ E + E +S R L Sbjct: 1444 LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE 1503 Query: 264 AAPREEKE--RETEAAQMEHQ-------KERNSFEERIQALEEDLREK---EREIATEKK 311 R+E+E RE EAAQ E + + R+ EE ++ALE RE + EI+ Sbjct: 1504 ERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD 1563 Query: 312 NSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYET 371 K+IQ L K+ E + E+ + +E+ A + Q + Q + + Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623 Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEE------- 424 L+ K+ A LR +N ++ E+ L+ S+ T+ ++ + ++++E DL + Sbjct: 1624 KLAEKDEECANLR-RNHQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGH 1680 Query: 425 AHREKSKGDCTIRDL----------RNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN 474 A R+ ++ R + R+E ++L E++E+ +A+E R L +E + Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAA 1740 Query: 475 QEQ-------VIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527 EQ + L E+T + ++L + ++ ++ Q L A DL S G + E Sbjct: 1741 LEQGERSRRLAEQELLEATERLNLL----HSQNTGLLNQKKKLEA--DLAQLS-GEVEEA 1793 Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE-SDSINNLQAELNK 586 ++ K KK +D + + LKKEQD HL + + ++ LQA L Sbjct: 1794 AQERREAEEKA-----KKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLE- 1847 Query: 587 IFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVE 646 E + + + +K +++ +++R E E + L + R + Sbjct: 1848 --------EAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKEL 1899 Query: 647 HFSQEELKKKVSDLIQLVKELYTDNQHLKK 676 + EE +K ++ + LV +L + + K+ Sbjct: 1900 AYQAEEDRKNLARMQDLVDKLQSKVKSYKR 1929 Score = 75.5 bits (184), Expect = 4e-13 Identities = 142/637 (22%), Positives = 262/637 (41%), Gaps = 89/637 (13%) Query: 69 ELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE--------- 119 +++K+ L+ R LEE ++ E + K E E+E L L+E Sbjct: 1152 QMQKKIKELQARAEELEEELEAE-RAARARVEKQRAEAARELEELSERLEEAGGASAGQR 1210 Query: 120 -----REQLLIKASKAVESLA---EAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDV 171 RE L + + +E A EA + ++R + + ++ + D L + LEK+ Sbjct: 1211 EGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEK 1270 Query: 172 TAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALV-LDEKDRLIEELKLS- 229 + + E++ A ET R ++ ++ + +E L+ A + ++E R + + Sbjct: 1271 SELRMEVDDLAANVET----LTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQR 1326 Query: 230 --LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS 287 L+++ + L EEK C +S G + L A EE R+ E E K +++ Sbjct: 1327 GRLQTESGELSRLLEEKE---CLISQLSRG--KALAAQSLEELRRQLE----EESKAKSA 1377 Query: 288 FEERIQALEED---LREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKL 344 +QAL D LRE+ E A E + L+R L +V + S+ E Sbjct: 1378 LAHAVQALRHDCDLLREQHEEEA-EAQAELQR---------LLSKANAEVAQWRSKYE-- 1425 Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKI 404 A + E L++A+ + ++ E + A ++L L TE+ + +++ Sbjct: 1426 -ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERA 1484 Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGDCTI-------RDLRNEVEKLRNEVNEREKAM 457 T + L +++ LE+ LEE R++ + + R L E+ +LR+ E +A+ Sbjct: 1485 TSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL 1544 Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLE 517 E L NK N ++ I LT+ + +Q+ + + + + AA + Sbjct: 1545 ET-----LKRENK---NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596 Query: 518 LRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI 577 + L K Q S+ ++K + EE + + Q V+SLQ S Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ----RAVESLQAS--- 1649 Query: 578 NNLQAEL---NKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFS---LYSDQTS 631 L AE N+ L+K++E D+ LE Q+ R+ E+ + L Q Sbjct: 1650 --LDAETRARNEALRLKKKMEGDL-------NDLELQLGHATRQATEAQAATRLMQAQLK 1700 Query: 632 YLSICLEENNRFQVE-HFSQEELKKKVSDLIQLVKEL 667 +E R E H + L+++ S L ++EL Sbjct: 1701 EEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737 Score = 75.1 bits (183), Expect = 6e-13 Identities = 124/565 (21%), Positives = 245/565 (43%), Gaps = 72/565 (12%) Query: 226 LKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGL--CAAPREEKERETEAAQMEHQK 283 +KL K K L EE+ ELRGL A E K +E E + + Sbjct: 879 MKLFFKMKPLLRSAQAEEELAAL-------RAELRGLRGALAAAEAKRQELEETHVSITQ 931 Query: 284 ERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEK 343 E+N ++QA +++L + E E+ + L + K + L+ K K++ E + E+ Sbjct: 932 EKNDLALQLQAEQDNLADAE-----ERCHLLIKSK------VQLEGKVKELSERLEDEEE 980 Query: 344 LSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403 ++A A R L+ T+ + +D + L+ E A ++ + E L S+ + Sbjct: 981 VNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR 1040 Query: 404 ITQELSDLQQERERLEKDLE-EAHREKSKGDCTIRDLRNEVEKLRNEVNEREK-AMENRY 461 +T+E LQ+ ++ DL+ E R + +R L +VE L + + +K M+ Sbjct: 1041 LTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLR-LEQQVEDLECSLEQEKKLRMDTER 1099 Query: 462 KSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ-----QNCYLMAAE-- 514 E + KL QE V ++ K L +K +KD E+ Q ++ L+ A+ Sbjct: 1100 AKRKLEGDLKL-TQESV----ADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQ 1154 Query: 515 ----DLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKS 570 +L+ R+E L E+ +++ ++ + + + + + EEL + L++ + Sbjct: 1155 KKIKELQARAEEL-EEELEAERAARAR-VEKQRAEAARELEELSERLEEAGGASAGQREG 1212 Query: 571 LQESDS-INNLQAELNK--------IFALRK-------QLEQDVLSYQNLRKTLEEQISE 614 ++ ++ + L+ EL + + ALR+ +L + V S Q +R+ LE++ SE Sbjct: 1213 CRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSE 1272 Query: 615 IRRREEESF----SLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTD 670 +R ++ +L + S +C ++ EEL+++++D L T+ Sbjct: 1273 LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE 1332 Query: 671 NQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEI-------NF 723 + L + + + C+ Q + LA+ EL E+E K + + Sbjct: 1333 SGELSRLLEEKECLISQLSR-GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391 Query: 724 LSDQHLQQSN---EIMKDLSKGGCK 745 L +QH +++ E+ + LSK + Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAE 1416 Score = 51.2 bits (121), Expect = 9e-06 Identities = 77/325 (23%), Positives = 150/325 (46%), Gaps = 24/325 (7%) Query: 62 DFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE 121 + + ++ E +E NL+ E +Q T + + LK ++E +L+ Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA-LRLKKKMEGDLNDLEL-- 1676 Query: 122 QLLIKASKAVESLAEAGGSEIQRVKEDA-RKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180 QL +A E+ A + Q +E A R + Q++ L ++ LE+ + AELE+ Sbjct: 1677 QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEE 1736 Query: 181 AFAGTET-EKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL-KLSLKSKEALIQ 238 A E E++ RL + L ++++ +L++K +L +L +LS + +EA + Sbjct: 1737 LRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQE 1796 Query: 239 CLK-EEKSQMACPDENVSSGELRGL--CAAPREEKERETEAAQMEHQKERNSFEE----- 290 + EEK++ A D + + EL+ +A E ++ E E Q E+ Sbjct: 1797 RREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG 1856 Query: 291 ---RIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAA 347 ++Q LE +RE E E+ E+K K +A++G ++ E++V+EL + E+ Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQK---KHAEALKG----VRKHERRVKELAYQAEEDRKN 1909 Query: 348 FAKAREALQKAQTQEFQGSEDYETA 372 A+ ++ + K Q++ +E A Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEEA 1934 Score = 50.1 bits (118), Expect = 2e-05 Identities = 68/324 (20%), Positives = 126/324 (38%), Gaps = 40/324 (12%) Query: 55 TRARN------------MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT 102 TRARN + D E Q+ ++ + ++ ++++E G E Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ--- 1710 Query: 103 NIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK 162 L E+ + L+ R LL + + + E G E +R+ +Q T+ Sbjct: 1711 --RLAAELHEQAQALERRASLLAAELEELRAALEQG--------ERSRRLAEQELLEATE 1760 Query: 163 RILLLEKDVTAA-----QAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLD 217 R+ LL T + E + A E E+A + R E++ K + + + + Sbjct: 1761 RLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK 1820 Query: 218 EKDRL--IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE 275 E+D +E +K +L+ +Q EE Q A +L E K RE E Sbjct: 1821 EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKL--------EAKVRELE 1872 Query: 276 AAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVE 335 A QK+ + ++ E ++E + ++KN + + L +KS +++ E Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE 1932 Query: 336 ELNSEIEKLSAAFAKAREALQKAQ 359 E + A + KA+ L A+ Sbjct: 1933 EAEQQANTNLAKYRKAQHELDDAE 1956 Score = 46.2 bits (108), Expect = 3e-04 Identities = 101/478 (21%), Positives = 168/478 (35%), Gaps = 80/478 (16%) Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELE-GYQNFIFQLQKHSQCS 1140 + SK Q KV + + + + ++K+ D TEL+ + L K + Sbjct: 958 IKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEK 1017 Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200 +A TE L++ D + + H + LG L E L Sbjct: 1018 QA-------TENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070 Query: 1201 N----LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQ 1256 L+QQ+E+ E L++E+ L M L+ + L Q + + Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK---------LTQESVADAAQD 1121 Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLF 1316 +QQ+++ + K EL Q S EQL A++ +K+++L Sbjct: 1122 KQQLEE-------------KLKKKDSELSQLS------LRVEDEQLLG-AQMQKKIKELQ 1161 Query: 1317 LNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376 + + E+ + R+E+ L E E E S Q++ Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSE----------RLEEAGGASAGQRE 1211 Query: 1377 DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS 1436 + E+ LR+ LEE+ +E L R+ +E Sbjct: 1212 GCRKREA-----------------ELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254 Query: 1437 IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLR---ESLSRKTVSLEH 1493 S + L E LR + L A + +R K R + LS + +E Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314 Query: 1494 LQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSR-----VQEEVKLRQQL 1546 LQR+ A + RLQ E E R L++E C +LSR Q +LR+QL Sbjct: 1315 LQRQLADASTQRGRLQTESGELSR----LLEEKECLISQLSRGKALAAQSLEELRRQL 1368 Score = 43.9 bits (102), Expect = 0.001 Identities = 85/422 (20%), Positives = 161/422 (38%), Gaps = 51/422 (12%) Query: 1379 ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE---RQGSEFVQGST 1435 E E+T V + DL ++ E L EE K + QLE ++ SE ++ Sbjct: 921 ELEETHVSITQEKNDLALQLQAEQDNLADA-EERCHLLIKSKVQLEGKVKELSERLEDEE 979 Query: 1436 SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495 + A + L E L+K L L K ++KQ +K++ +L Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVK-----------NLT 1028 Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555 E A++ E RL KE + +QQ + +++ E RV K + +L Q + L Sbjct: 1029 EEMAALDESVARLTKEKKALQEAHQQALGDLQA---EEDRVSALTKAKLRLEQQVEDLEC 1085 Query: 1556 SLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDS 1615 SL E+ ++LR M+++ + + +T +SV++ + D Sbjct: 1086 SL-----------EQEKKLR------MDTERAKRKLEGDLKLTQESVAD----AAQDKQQ 1124 Query: 1616 LSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQ 1675 L + +S V L ++ + + L E L +++ + A ++ Q Sbjct: 1125 LEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQ 1184 Query: 1676 TQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL-LWRVSLPEDGQCPL 1734 EA + LS+ + A E R+ + L R+ + Sbjct: 1185 RAEAARELEE-----------LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233 Query: 1735 HCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGN 1794 H + ++ + + +L EQ LQ + L+ K + ++ D L + L +A+ + Sbjct: 1234 HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKAS 1293 Query: 1795 LE 1796 E Sbjct: 1294 AE 1295 Score = 41.6 bits (96), Expect = 0.007 Identities = 178/889 (20%), Positives = 327/889 (36%), Gaps = 106/889 (11%) Query: 953 RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKT------- 1005 RL +EV L ++ +L+ E E K L KL LA+A E + T +K Sbjct: 974 RLEDEEEVNADLAARRRKLEDECTELKKDIDDL--KLTLAKAEKEKQATENKVKNLTEEM 1031 Query: 1006 ---------LLNAQPPVGAAYQDSPGEQKGIKTTSSVW-----------RDKEMDSDQQR 1045 L + + A+Q + G+ + + S D E +Q++ Sbjct: 1032 AALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEK 1091 Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTS-VATYLSSKSQPSAKVSVMGTD-QSESI 1103 +D+E L +E+ D + L K +++S+ D Q Sbjct: 1092 KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA 1151 Query: 1104 NTSNETEYLKQKIHDLETELEGYQNFIFQLQKH--------SQCSEAIITVLCGTEGAQD 1155 + + L+ + +LE ELE + +++K + SE + + G ++ Sbjct: 1152 QMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQRE 1211 Query: 1156 GLSKPKN--GSDGEEMTFSSLHQVRYV-----KHVKILGPLAPEMIDSRVLENLKQQLEE 1208 G K + G E+ ++L V K + L E +DS L+ ++Q+LE+ Sbjct: 1212 GCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELG-EQVDS--LQRVRQKLEK 1268 Query: 1209 QEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ--QIKDGHGI 1266 ++ +L+ E + + + L D L +++ + LQRQ G Sbjct: 1269 EKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGR 1328 Query: 1267 CVISRQHMNTMIKAFEELL-QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVE 1325 ++ +++ E L+ Q S A+ +E Q E + L +++ + Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHD 1388 Query: 1326 MNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385 + E E E Q LL ++ A S YE R ++ + +K ++ Sbjct: 1389 CDLLREQHEEEAEAQAELQRLLSKANAEVAQWR-SKYEADA---IQRTEELEEAKKKLAL 1444 Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF-VQGSTSIFASGSEL 1444 + E ++ LE++ KLR Q E + ++ +TS A+ + Sbjct: 1445 RLQEAE-----EGVEAANAKCSSLEKA-----KLRLQTESEDVTLELERATSAAAALDKK 1494 Query: 1445 HSSLTSEIHFLRKQNQALNAMLIKGSRDKQ---KENDKLRESLSRKTVSLEHLQREYASV 1501 L + R+Q + + L R+ + E +LR +LE L+RE ++ Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554 Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL 1561 +EE L + S + Q+L + + E S +Q ++ + L + +++EL Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLEL 1614 Query: 1562 ---------KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSG-- 1610 K EK DEE LR + +ES + D+ +++ + G Sbjct: 1615 SQVKAEVDRKLAEK-DEECANLRRNHQRAVESLQA--SLDAETRARNEALRLKKKMEGDL 1671 Query: 1611 NDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLA 1670 ND + + AT +RL+ L + GR + QRL A Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQA-QLKEEQAGR----------------DEEQRLAA 1714 Query: 1671 EMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDG 1730 E+ Q Q S A L + S A+ L EA RL LL + Sbjct: 1715 ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLN 1774 Query: 1731 QCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQN-----TMKLLQLSKRQE 1774 Q + ++ EV + ++ E E+K + M +L K Q+ Sbjct: 1775 QKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD 1823 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 98.2 bits (243), Expect = 6e-20 Identities = 146/647 (22%), Positives = 267/647 (41%), Gaps = 101/647 (15%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123 EN++TE++ L L+E++Q E EL E E L+ L ++Q Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAE------------TELCAEAEELRARLTAKKQE 912 Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183 L + +E+ E Q ++ + +K Q +++L + LE++ +A Q Sbjct: 913 LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ----LEEEESARQ-------- 960 Query: 184 GTETEKALRLRLESKLSE--MKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL- 240 +L+LE +E +KK+ E + + D+ +L +E KL L Sbjct: 961 --------KLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLT 1009 Query: 241 -KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDL 299 +EEKS+ +N + L EE+ R E + E +K R E L + + Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDL-----EERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064 Query: 300 REKEREIATEKKNSLKRDKAIQGLTMALKSKE-------KKVEELNSEIEKLSAAFAKAR 352 E + +IA K K+++ +Q ++ + KK+ EL S+I +L R Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124 Query: 353 EALQKAQTQEFQGSEDYETALSGKE------ALSAALRSQ-----NLTKSTENHRLRRSI 401 + KA+ Q+ E+ E + E A LRS+ N+ K T + Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184 Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRY 461 +I + Q E L + LE+ R K+ + + L NE +L NEV Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV----------- 1233 Query: 462 KSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSE 521 K LL H +++V L E L KFNE + V + + +EL + Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQE-------LQVKFNEGE-RVRTELADKVTKLQVELDNV 1285 Query: 522 GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQ 581 + + S+ +K FS + Q D +EL+Q +++ L S + ++ Sbjct: 1286 TGLLSQSDSKSSKLTKD-FSALESQLQDTQELLQEENRQK---------LSLSTKLKQVE 1335 Query: 582 AELNKIFALRKQLEQDVLSYQNLRK---TLEEQISEIRRREEESFSLYSDQTSYLSICLE 638 E N + R+QLE++ + NL K TL Q+++++++ E+S + Sbjct: 1336 DEKN---SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK 1392 Query: 639 E----NNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681 + + R + + + ++L+K + L Q + +L D H +++ +L Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439 Score = 79.7 bits (195), Expect = 2e-14 Identities = 121/616 (19%), Positives = 267/616 (43%), Gaps = 68/616 (11%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123 +++ ++L K+ L+ ++ +E +Q+E K +++ E S + +L+E E+ Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK-QVEDEKNSFREQLEEEEEA 1351 Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183 K + +L A +++++ ED+ ++ E++ K L+KD+ E+ A Sbjct: 1352 KHNLEKQIATL-HAQVADMKKKMEDSVGCLETAEEVKRK----LQKDLEGLSQRHEEKVA 1406 Query: 184 GTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEE 243 + + + RL+ +L ++ + A L++K + ++L L EE Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL-------------LAEE 1453 Query: 244 KSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-KERNSFEERIQALEEDLREK 302 K+ +S+ A E +E+ET+A + +E + ++ L + R + Sbjct: 1454 KT--------ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505 Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362 ++ + K + K++ L + ++ E++VEE+ +++E+L +A + + Sbjct: 1506 MEDLMSSKDDV---GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562 Query: 363 FQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDL 422 +E L G++ S + Q L R ++++ EL D ER ++ + Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQ----------LVRQVREMEAELED-----ERKQRSM 1607 Query: 423 EEAHREKSKGDCTIRDLRNEVE---KLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479 A R+K + D ++DL ++ K R+E ++ + ++ + K + E + ++E+++ Sbjct: 1608 AVAARKKLEMD--LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665 Query: 480 KHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539 E N+K K + E+IQ L AAE + +++ E K Sbjct: 1666 AQAKE--NEK-----KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718 Query: 540 FSKEKKQ--SSDYEELIQVLKKEQD----IYTHLVKSLQESDSINNLQAELNKIFALRKQ 593 + E+K+ + +L + L++EQ I L K+ + D IN L + A + + Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT-DLNLERSHAQKNE 1777 Query: 594 LEQDVLSYQN--LRKTLEEQISEIRRREEESFSLYSDQTSYLSICLE-ENNRFQVEHFSQ 650 + L QN L+ L+E ++ + + S + + + L L+ E Q Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837 Query: 651 EELKKKVSDLIQLVKE 666 +KK+ D++ V + Sbjct: 1838 RRTEKKLKDVLLQVDD 1853 Score = 72.8 bits (177), Expect = 3e-12 Identities = 120/531 (22%), Positives = 215/531 (40%), Gaps = 89/531 (16%) Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQAL 295 L+Q ++E+ MA +E V E + L A E + E E Q + E+ +E++QA Sbjct: 837 LLQVSRQEEEMMAKEEELVKVRE-KQLAA---ENRLTEMETLQSQLMAEKLQLQEQLQAE 892 Query: 296 EEDLREKE--REIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKARE 353 E E E R T KK L+ E +VEE + L A K ++ Sbjct: 893 TELCAEAEELRARLTAKKQELEE---------ICHDLEARVEEEEERCQHLQAEKKKMQQ 943 Query: 354 ALQ--KAQTQEFQGSED--------YETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403 +Q + Q +E + + E L E L QN + E L I + Sbjct: 944 NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003 Query: 404 ITQELSDLQQERERLEK----------DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNER 453 T L++ +++ + L K DLEE R + K + R ++E +++++ Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063 Query: 454 EKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAA 513 ++ + L + KK + + + E QK++ L+K E + ++ + Sbjct: 1064 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE------LQ 1117 Query: 514 EDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE 573 EDLE +E+ S +K +KQ D E ++ LK E + Sbjct: 1118 EDLE-------SERASR----------NKAEKQKRDLGEELEALKTELE----------- 1149 Query: 574 SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633 D++++ A+ LR + EQ+V L+KTLEE+ + +E +S L Sbjct: 1150 -DTLDSTAAQQE----LRSKREQEV---NILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201 Query: 634 SICLEENNRFQVE-HFSQEELKKKVSDLIQLVKELYT---DNQHLKKTIFDLSCMGFQGN 689 + LE+ R + +++ L+ + +L VK L D++H +K + + Q Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV-EAQLQELQVK 1260 Query: 690 GFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS 740 TE LA K + +++ D + L Q +S+++ KD S Sbjct: 1261 FNEGERVRTE----LADKVTKLQVEL---DNVTGLLSQSDSKSSKLTKDFS 1304 Score = 72.8 bits (177), Expect = 3e-12 Identities = 104/462 (22%), Positives = 195/462 (42%), Gaps = 64/462 (13%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEH-IYKTNIELK 107 +ET + + AR +++ Q EL E N + R + ++ G + H + K+ L+ Sbjct: 1474 KETKALSLARALEEAMEQKAEL--ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531 Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167 +VE +K +L+E E L +A E +Q +K + +Q ++ ++ L Sbjct: 1532 QQVEEMKTQLEELEDEL----QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587 Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM--------KKMHEGDLAMALVLDEK 219 + V +AELE A R +LE L ++ K E + + + Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647 Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM 279 + EL + S+E ++ KE + ++ + + + L AA R +++ + E ++ Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAAAERAKRQAQQERDEL 1706 Query: 280 EHQ------------KERNSFEERIQALEEDLREKE--REIATE--KKNSLKRDKAIQGL 323 + +E+ E RI LEE+L E++ E+ + KK +L+ D+ L Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766 Query: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAAL 383 + +S +K E ++E+ + +E K Q E Y+ +++ EA A L Sbjct: 1767 NLE-RSHAQKNENARQQLERQN------KELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819 Query: 384 RSQ--NLTKSTEN--HRLRRSIKKITQELSDLQQER-----------------ERLEKDL 422 Q N TK + ++RR+ KK+ L + ER ++L++ L Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879 Query: 423 EEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL 464 EEA E + + + R L+ E+E + E AM SL Sbjct: 1880 EEAEEEAQRANASRRKLQRELE----DATETADAMNREVSSL 1917 Score = 72.4 bits (176), Expect = 4e-12 Identities = 103/469 (21%), Positives = 201/469 (42%), Gaps = 88/469 (18%) Query: 97 EHIYKTNIELKVEVESLKRELQEREQL---LIKASKAVESLAEAGGSEIQRVKEDARKKV 153 + + KT L+ E++ L +L + Q L K K + L + + E+ + Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468 Query: 154 QQVEDLLTKRILLLE--KDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLA 211 + + TK + L ++ +AELE+ TE + + SK K +HE + + Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTE--MEDLMSSKDDVGKSVHELEKS 1526 Query: 212 MALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSG---ELRGLCAAPRE 268 + ++ +EE+K L+ E +Q ++ K ++ + + + +L+G E Sbjct: 1527 KRAL----EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582 Query: 269 EKE------RETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQG 322 +K+ RE EA + +K+R+ + LE DL++ E I + KN RD+AI+ Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---RDEAIKQ 1639 Query: 323 L------------------------TMALKSKEKKVEELNSEIEKLSAAFAKAREALQKA 358 L K EKK++ + +E+ +L A A A ++A Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699 Query: 359 QTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE-- 416 Q + + +++ + SGK AL+ E RL I ++ +EL + Q E Sbjct: 1700 QQERDELADEIANS-SGKGALAL----------EEKRRLEARIAQLEEELEEEQGNTELI 1748 Query: 417 --RLEK------------DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462 RL+K +LE +H +K++ + L + ++L+ ++ E E ++++YK Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNEN--ARQQLERQNKELKVKLQEMEGTVKSKYK 1806 Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQ------------KDVLLQKFNEK 499 + ++ K+ E+ + + T+ KDVLLQ +E+ Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855 Score = 69.7 bits (169), Expect = 2e-11 Identities = 168/804 (20%), Positives = 310/804 (38%), Gaps = 127/804 (15%) Query: 811 EQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDEL-KLSCEAQLVKAGEVPKVGLK 869 E+E +HL + +K + EL ++ ++ +L K++ EA+L K E ++ L+ Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE-EQIILE 984 Query: 870 DASVQTVATEGDLLRFK-HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGI 928 D + + +A E LL + E T EE+ + +L+ + +N H +A + L Sbjct: 985 DQNCK-LAKEKKLLEDRIAEFTTNLTEEEEKSKSLA---KLKNKH-----EAMITDLEER 1035 Query: 929 TNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQK 988 RE K+ + L K R L + T L QI ELQ ++ E K + ++ Sbjct: 1036 LRREEKQRQE--LEKTRRKL---------EGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084 Query: 989 LILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYE 1048 L A A +E L K I+ S + + D + +R+ Sbjct: 1085 LQAALARVEEEAAQKNMAL-----------------KKIRELESQISELQEDLESERASR 1127 Query: 1049 IDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE 1108 +E D L + K ED L T+ L SK + + +N + Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE-------------QEVNILKK 1174 Query: 1109 TEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEE 1168 T + K H+ + + QKHSQ E + L T+ + L K K + E Sbjct: 1175 TLEEEAKTHEAQIQE--------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226 Query: 1169 MTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIH 1228 ++ VK+L L + + ++ QL+E + K + + + +L ++ Sbjct: 1227 GELAN--------EVKVL--LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276 Query: 1229 NLQNKFRDLSP--PRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286 LQ + +++ + DS ++ S Q++D + ++ + +L Q Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL---QEENRQKLSLSTKLKQ 1333 Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNE--------------- 1331 D F+EQL + E LEK + +M + E Sbjct: 1334 VEDEK----NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389 Query: 1332 -------LMERIEEDNLTYQHLLPESP--EPSASHALSDYETSEKSFFSRDQKQDN---- 1378 L +R EE Y L + L D + +S + ++KQ Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449 Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437 EKT + +D +E T L +++ + + +LER +F + Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509 Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497 +S ++ S +H L K +AL + + ++ D+L+ + K L+ Sbjct: 1510 MSSKDDVGKS----VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL----RLEVN 1561 Query: 1498 YASVKEENER-LQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQS 1556 ++K + ER LQ + E +QL+++VR EL ++E K R ++ KL Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL---EDERKQRSMAVAARKKLEMD 1618 Query: 1557 LRVELKAY-----EKLDEEHRRLR 1575 L+ +L+A+ + DE ++LR Sbjct: 1619 LK-DLEAHIDSANKNRDEAIKQLR 1641 Score = 63.2 bits (152), Expect = 2e-09 Identities = 226/1187 (19%), Positives = 445/1187 (37%), Gaps = 191/1187 (16%) Query: 440 RNEVEKLRNE-----VNEREKAMENRYKSLLSESNK----KLHNQEQVIKHLTESTNQKD 490 R E E + E V E++ A ENR + + ++ KL QEQ ++ TE + + Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ-LQAETELCAEAE 900 Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550 L + K E +++ C+ DLE R E E+C Q +++KK + Sbjct: 901 ELRARLTAKKQE-LEEICH-----DLEARVEEE-EERCQHLQ--------AEKKKMQQNI 945 Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEE 610 +EL + L++E+ L + + + +A+L K+ + LE +K LE+ Sbjct: 946 QELEEQLEEEESARQKL-----QLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLLED 999 Query: 611 QISE----IRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKE 666 +I+E + EE+S SL + + ++ + R + E ++EL+K ++ Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR-------RK 1052 Query: 667 LYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSD 726 L D+ L I +L E LA KE+E + +E Sbjct: 1053 LEGDSTDLSDQIAELQAQ------------IAELKMQLAKKEEELQAALARVEE------ 1094 Query: 727 QHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKAT 786 Q N +K + R ES+IS+ L+E + EK Sbjct: 1095 -EAAQKNMALKKI----------RELESQISE---------LQEDLESERASRNKAEKQK 1134 Query: 787 LLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPH 846 L + LK E L ++ S + K ++ H Q + H Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194 Query: 847 DELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLR-------------FKHEATREA 893 + QL + V K L+ A G+L K + Sbjct: 1195 SQAVEELAEQLEQTKRV-KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253 Query: 894 WEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYR 953 +E + R E V Q L ++ G+ ++ KS L K +L + + Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK--LTKDFSALES--Q 1309 Query: 954 LPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPV 1013 L TQE++ + Q L L +LK+ + ++L E TL + Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369 Query: 1014 GAAYQDSPGEQKGIKTTSSVWR--DKEMDSDQQRSYEIDSEICPPDDLASLPS-CKENPE 1070 +DS G ++T V R K+++ QR E ++ D L + ++ + Sbjct: 1370 KKKMEDSVG---CLETAEEVKRKLQKDLEGLSQRHEE---KVAAYDKLEKTKTRLQQELD 1423 Query: 1071 DVLSPTSVATYLSSKSQPSAKV--SVMGTDQSESINTSNETEYLKQKIHDLETEL----E 1124 D+L + + K ++ +++ S + E + + + + ET+ Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483 Query: 1125 GYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVK 1184 + + Q + + ++ T + ++D + K S+H++ K Sbjct: 1484 ALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK-------------SVHELEKSKRAL 1530 Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKF-RDL------ 1237 + +E +K QLEE E +LQ ++ ++L + ++ +F RDL Sbjct: 1531 -----------EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579 Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVA-- 1295 S + LV+ Q RE+ + + + + V +R+ + +K E + +++ + A Sbjct: 1580 SEEKKKQLVR-QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638 Query: 1296 --EGFQEQLNQCA-----------ELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLT 1342 Q Q+ C E+L + ++ KS+ EM E + E Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698 Query: 1343 YQHLLPESPEPSASH------ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLM 1396 Q E + A+ AL + E +++ + E T ++ + + L Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758 Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF------VQGS---------TSIFASG 1441 I +I T + NE R+QLERQ E ++G+ T++ A Sbjct: 1759 --IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI 1816 Query: 1442 SELHSSLTSE-------IHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL 1494 ++L L +E +R+ + L +L++ D+++ ++ ++ + + L+ L Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQL 1875 Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541 +R+ +EE +R + +R + + +E+S ++ +++ Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922 Score = 62.8 bits (151), Expect = 3e-09 Identities = 137/622 (22%), Positives = 256/622 (41%), Gaps = 68/622 (10%) Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKF----RDLSPPRYDSLVQSQARELS 1254 +E L+ QL ++ +LQ++ +L +E L+ + ++L +D + + E Sbjct: 871 METLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEER 930 Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314 Q Q + ++ M I+ EE L+ + + Q + L+KLE+ Sbjct: 931 CQHLQAE---------KKKMQQNIQELEEQLEEEE---SARQKLQLEKVTTEAKLKKLEE 978 Query: 1315 LFLNGKSVGVEMNTQNELME-RIEE--DNLTYQHLLPESPEPSASHALSDYE---TSEKS 1368 + + ++ + +L+E RI E NLT + E S + + +E T + Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE----EEKSKSLAKLKNKHEAMITDLEE 1034 Query: 1369 FFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-KTNEKLRKQLERQG 1427 R++KQ E EKT + S DL + I E++ L+ + K E+L+ L R Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDL-SDQIAELQAQIAELKMQLAKKEEELQAALARVE 1093 Query: 1428 SEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRK 1487 E Q + ++ EL S + SE+ + +A K RD +E + L+ L Sbjct: 1094 EEAAQKNMAL-KKIRELESQI-SELQEDLESERASRNKAEKQKRDLGEELEALKTELE-D 1150 Query: 1488 TVSLEHLQREYASVKEENERLQKEGSEKE------------RHNQQLIQEVRCSGQELSR 1535 T+ Q+E S +E+ + K+ E+E + + Q ++E+ ++ R Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210 Query: 1536 VQEEV-KLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSS 1594 V+ + K +Q L ++ +L ++V L+ K D EH+R + + E F+ + Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQG--KGDSEHKR-KKVEAQLQELQVKFNEGERV 1267 Query: 1595 QAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTP----CVSRLVTGHHLWASKNGRHVLG 1650 + V++ N T LS S+ T S+L L +N R L Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN-RQKLS 1326 Query: 1651 LIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLT 1710 L LKQ+ + E + +EA + +++ T A + K + T Sbjct: 1327 L----STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382 Query: 1711 LEEAYRRLKLLWRVSLPEDGQCPLHCEQIG---EMKAEVTKLHKKLFEQEKKLQN-TMKL 1766 EE R+L+ +G H E++ +++ T+L ++L + L + Sbjct: 1383 AEEVKRKLQ------KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436 Query: 1767 LQLSKRQEKVIFDQLVVTHKIL 1788 L K+Q+K FDQL+ K + Sbjct: 1437 CNLEKKQKK--FDQLLAEEKTI 1456 Score = 62.0 bits (149), Expect = 5e-09 Identities = 78/402 (19%), Positives = 176/402 (43%), Gaps = 35/402 (8%) Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ- 118 +++ E+++ + L++ + ++ + +++ G E + +L +V ++ EL+ Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600 Query: 119 EREQ--LLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-RILLLEKDVTAAQ 175 ER+Q + + A K +E + + I ++ + ++Q+ L + + + E D T A Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660 Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK-------L 228 E E E EK L+ + +++ + A E+D L +E+ L Sbjct: 1661 RE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719 Query: 229 SLKSK---EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQME-HQKE 284 +L+ K EA I L+EE + E ++ + + + E + + ++ Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA 1779 Query: 285 RNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE-LNSEIEK 343 R E + + L+ L+E E + ++ K S+ AL++K ++EE L++E ++ Sbjct: 1780 RQQLERQNKELKVKLQEMEGTVKSKYKASIT----------ALEAKIAQLEEQLDNETKE 1829 Query: 344 LSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403 AA + R +K + Q ++ A K+ A ST +L+R +++ Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA--------STRLKQLKRQLEE 1881 Query: 404 ITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445 +E R +L+++LE+A + + L+N++ + Sbjct: 1882 AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923 Score = 38.5 bits (88), Expect = 0.060 Identities = 82/428 (19%), Positives = 162/428 (37%), Gaps = 45/428 (10%) Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIH 1453 LL QE + K EE +K EK + E + +E + + A +L L +E Sbjct: 837 LLQVSRQEEEMMAKE-EELVKVREK-QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894 Query: 1454 FLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGS 1513 L + + L A L ++ ++ L + + +HLQ E +++ + L+++ Sbjct: 895 -LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953 Query: 1514 EKERHNQQLIQEVRCSGQELSRVQEE-VKLRQQ--LLSQNDKLLQSLRVEL--------- 1561 E+E Q+L E + +L +++EE + L Q L++ KLL+ E Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013 Query: 1562 --KAYEKLDEEH--------RRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGN 1611 K+ KL +H RLR +K E + + + ++E Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073 Query: 1612 DTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGR---HVLGLIEDYEALLKQISQGQRL 1668 L+ + V ++ K + L ED E+ ++ ++ Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133 Query: 1669 LAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPE 1728 ++ + + + L + SK V+ K TLEE Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE--------------- 1178 Query: 1729 DGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKIL 1788 + H QI EM+ + ++ ++L EQ ++ + L+ +K+ + +L K+L Sbjct: 1179 --EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236 Query: 1789 RKARGNLE 1796 + +G+ E Sbjct: 1237 LQGKGDSE 1244 >gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] Length = 1498 Score = 98.2 bits (243), Expect = 6e-20 Identities = 152/690 (22%), Positives = 295/690 (42%), Gaps = 105/690 (15%) Query: 64 ENQITELKKENFNLKLRIYFLEERMQ---QEFHGPTEHIYKTNIEL-KVEVESLKRE--- 116 + Q+ L++E+ +L ++ +E +Q Q H + L +++ E+ RE Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768 Query: 117 -LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175 L + E+++++A+ A++G E+ R + ++ + L K L +++ Sbjct: 769 CLLQNEKIILEAALQA---AKSGKEELDRGARRLEEGTEETSETLEK----LREELAIKS 821 Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA 235 ++E T K +++ + + K M E A KD+LI ELK + K ++ Sbjct: 822 GQVEHLQQETAALKKQMQKIKEQFLQQKVMVE---AYRRDATSKDQLISELKATRKRLDS 878 Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER--ETEAAQMEHQKERNSFEERIQ 293 ++ L++E Q+ ++ + EL L + ++ + E QKER+ E +Q Sbjct: 879 ELKELRQELMQVH-GEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQ 937 Query: 294 ALE--------------------EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKK 333 +L+ E+L+++ R+ TE+K ++R + LT A K + K Sbjct: 938 SLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGS--DLTSAQKEMKTK 995 Query: 334 VEELNSEIEKLSAAFAKAREALQKAQTQEFQ-----GSEDYETALSGK-EALSAALRSQN 387 + + + LS +A A + A + Q GS D AL + +AL A L++ + Sbjct: 996 HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVS 1055 Query: 388 LTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447 +K+ L+ I +QEL + +++ LE +L+E+ + K I+ L +KL Sbjct: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK----IKRLEESNKKLA 1111 Query: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIK--------HLTESTNQKDVLLQKFNEK 499 E+ + + L +SN L +++ L + Q +LQ+ E+ Sbjct: 1112 LELEHEKGKLTG-----LGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166 Query: 500 DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPG---------SKTIFSKEKKQSSDY 550 D ++ L A+ + E + E+ ++ + + S+ KK+ Sbjct: 1167 DRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK 1226 Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA----LRKQLEQDVLSY----- 601 E L+Q L+ E D ++ + S I QAEL + A L+KQL++ + Sbjct: 1227 EHLVQKLQAEADDLQ--IREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQ 1284 Query: 602 --QNLRKTLEEQISEIR-------------RREEESFS-LYSDQTSYLSICLEENNRFQV 645 +NL+ ++++ EI+ R+E E L + S L + E+ + Q Sbjct: 1285 EMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQK 1344 Query: 646 EHFSQEELKKKVSDLIQLVKELYTDNQHLK 675 + F L+ KVS+L +K L NQ LK Sbjct: 1345 DKFM---LQAKVSELKNNMKTLLQQNQQLK 1371 Score = 78.6 bits (192), Expect = 5e-14 Identities = 127/581 (21%), Positives = 240/581 (41%), Gaps = 64/581 (11%) Query: 106 LKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRIL 165 LK+E SL ++L E + +K + A+ G E + ++A Q+++ T Sbjct: 613 LKLENVSLSQQLTETQHRSMKEKGRIA--AQLQGIEADMLDQEAA--FMQIQEAKT---- 664 Query: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK-KMHEGDLAMALVLDEKDRLIE 224 ++E+D+ E E + LE +L ++K + + D + + E L++ Sbjct: 665 MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724 Query: 225 ELKLS---LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH 281 +L L+ L+S+E + L+ ++ GEL+G E RE + Sbjct: 725 QLTLTQEALQSREQSLDALQTHYDEL-----QARLGELQG------EAASREDTICLL-- 771 Query: 282 QKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEI 341 Q E+ E +QA + E +R ++ + + + ++ L L K +VE L E Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE- 830 Query: 342 EKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSI 401 +AA K + +++ Q+ E Y + K+ L + L++ RL + Sbjct: 831 ---TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATR-------KRLDSEL 880 Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMEN-- 459 K++ QEL + E+ E +L HRE ++ + DL ++ + E +E E +++ Sbjct: 881 KELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ 940 Query: 460 ---RYKSLLSESNKKLHN-----QEQVIKHLTESTNQKDVLLQKFNEKDLEV-IQQNCYL 510 ++E+N+ L Q++ K +TE + L E+ + Y Sbjct: 941 FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYE 1000 Query: 511 MAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTH---- 566 A L R + + K ++ G S E IQ L+ E +H Sbjct: 1001 NAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL 1060 Query: 567 LVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREE--ESFS 624 L K LQE ++ + + E ++ L +LE ++ + RK +I+R EE + + Sbjct: 1061 LEKELQEVIALTSQELEESREKVL--ELEDELQESRGFRK-------KIKRLEESNKKLA 1111 Query: 625 LYSDQTSYLSICLEENNRFQVEHFS--QEELKKKVSDLIQL 663 L + L ++N EH S + L K+ +DL+QL Sbjct: 1112 LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152 Score = 57.8 bits (138), Expect = 1e-07 Identities = 203/1130 (17%), Positives = 429/1130 (37%), Gaps = 136/1130 (12%) Query: 275 EAAQMEHQKERNSFEERIQA----------LEEDLREKEREIATEKKNSLKRDKAIQGLT 324 +AA EHQ + +++ LE E + E+ K ++ + ++ L+ Sbjct: 366 QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425 Query: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR 384 + K+ EL +++ LS E +Q ++ S + +T L A+ Sbjct: 426 LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485 Query: 385 SQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE 444 +N L S +L +++ +RL +E+ R D T+ DLR ++ Sbjct: 486 DLQNMLEAKNASLASS----NNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMT 541 Query: 445 KLRNEVNE---REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDL 501 L++++ + + ++ K+ +E + L + Q + + V LQ E Sbjct: 542 ALQSQLQQVQLERTTLTSKLKASQAEIS-SLQSVRQWYQQQLALAQEARVRLQ--GEMAH 598 Query: 502 EVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQ 561 + Q E L+L + L SQQ ++ KEK + + + I+ +Q Sbjct: 599 IQVGQMTQAGLLEHLKLENVSL------SQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652 Query: 562 DIYTHLVKSLQESDSI--NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRRE 619 + +QE+ ++ +LQ L + R++L++ S +L + LE+ + +R+ Sbjct: 653 EA---AFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRD 709 Query: 620 EESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIF 679 ++ +L + + Q S + L+ +L + EL + + TI Sbjct: 710 QQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTIC 769 Query: 680 DL--------SCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQ 731 L + + +G + + E + E K+ E+ I +HLQQ Sbjct: 770 LLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQ 829 Query: 732 SNEIMKD---------LSKGGCKNGYLRHTESK---ISDCDGAHAPGCLEEGAFINLLAP 779 +K L + Y R SK IS+ E L Sbjct: 830 ETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQ 889 Query: 780 LFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQT 839 + EK T + +L ++ RE+ + + + L+G + K++ E+ +Q+ Sbjct: 890 VHGEKRT----AEAELSRLHREVAQVRQHMAD-------LEGHLQSAQKERDEMETHLQS 938 Query: 840 NSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPI 899 F K Q+V E + A + + + EA + E+K Sbjct: 939 LQFDK----------EQMVAVTEANE-----------ALKKQIEELQQEARKAITEQKQK 977 Query: 900 NTAL-----SAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRL 954 L SA+ + H A + GI +R +++ L LG + Sbjct: 978 MRRLGSDLTSAQKEMKTKH------KAYENAVGILSRRLQEA-LAAKEAADAELGQLRAQ 1030 Query: 955 PATQEVVTQLQSQILELQGELKEFKTCNKQLHQKL--ILAEAVMEGRPTPDKTLLNAQPP 1012 + + L +I L+ EL+ L ++L ++A E + +K L Sbjct: 1031 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL-----E 1085 Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSY-----EIDSEICPPDDLASLPSCKE 1067 + Q+S G +K IK + ++ + ++ + ++ + + + K Sbjct: 1086 LEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKR 1145 Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127 + V V L K + ++ + +++ S E E K+K++ L+ ++ + Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKHL----VQALQASLEKE--KEKVNSLKEQVAAAK 1199 Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187 ++H + + ++ + A++ L + K ++ +++ Q+R KH + + Sbjct: 1200 VEAGHNRRHFKAASLELSEVKKELQAKEHLVQ-KLQAEADDL------QIREGKHSQEIA 1252 Query: 1188 PLAPEMIDSRV-LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLV 1246 E+ ++R L+ L++QL+EQ L K+ N ++ + + K R+ + Sbjct: 1253 QFQAELAEARAQLQLLQKQLDEQ---LSKQPVGNQEMENLKWEVDQKERE---------I 1300 Query: 1247 QSQARELSLQRQQ-IKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305 QS ++L L QQ K+ G+ + + + + A E+L + + E N Sbjct: 1301 QSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNM 1360 Query: 1306 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355 LL++ ++L L+ + + T+ E N +P+ P P++ Sbjct: 1361 KTLLQQNQQLKLDLRRGAAK--TRKEPKGEASSSNPATPIKIPDCPVPAS 1408 Score = 57.0 bits (136), Expect = 2e-07 Identities = 84/438 (19%), Positives = 186/438 (42%), Gaps = 54/438 (12%) Query: 55 TRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLK 114 T ++++ + Q+ + + N LK +I L++ ++ + + + +L + +K Sbjct: 934 THLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMK 993 Query: 115 RE----------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164 + L R Q + A +A + AE G Q D+ + + L + Sbjct: 994 TKHKAYENAVGILSRRLQEALAAKEAAD--AELGQLRAQGGSSDSSLALHERIQALEAEL 1051 Query: 165 LLLEKDVTAAQAELEKAFAGTETE----KALRLRLESKLSE-------MKKMHEGDLAMA 213 + T + EL++ A T E + L LE +L E +K++ E + +A Sbjct: 1052 QAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLA 1111 Query: 214 LVLD-EKDRL--IEELKLSLKSKEALIQ-CLKEEKSQMACPDENVSSGELRGLCAAPREE 269 L L+ EK +L + + +L+ ++++ L + ++ + + V + R +EE Sbjct: 1112 LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR------KEE 1165 Query: 270 KERETE------AAQMEHQKER-NSFEERIQALEEDLREKER-------EIATEKKNSLK 315 ++R+ + A +E +KE+ NS +E++ A + + R E++ KK Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQA 1225 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ-------GSED 368 ++ +Q L + + + + EI + A A+AR LQ Q Q + G+++ Sbjct: 1226 KEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQE 1285 Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE 428 E + ++S + R+ ++ + Q L +++ E E ++DL ++ Sbjct: 1286 MENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKD 1345 Query: 429 KSKGDCTIRDLRNEVEKL 446 K + +L+N ++ L Sbjct: 1346 KFMLQAKVSELKNNMKTL 1363 Score = 54.3 bits (129), Expect = 1e-06 Identities = 125/623 (20%), Positives = 244/623 (39%), Gaps = 81/623 (13%) Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAY 1017 QE T ++ +LQ L+EF+ ++L + A ++ + TLL + A Sbjct: 660 QEAKTMVEE---DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716 Query: 1018 QDSPGEQKGIKTTSSVWRDKEMDSD---------QQRSYEIDSEICPPDDLASLPSCKEN 1068 Q+ K + T + +E D Q R E+ E +D C Sbjct: 717 QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI----CLLQ 772 Query: 1069 PEDVLSPTSVATYLSSKSQ--PSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126 E ++ ++ S K + A+ GT++ TS E L++++ ++E Sbjct: 773 NEKIILEAALQAAKSGKEELDRGARRLEEGTEE-----TSETLEKLREELAIKSGQVEHL 827 Query: 1127 QNFIFQLQKHSQ-CSEAIITVLCGTEG-AQDGLSKPKNGSDGE------EMTFSSLHQVR 1178 Q L+K Q E + E +D SK + S+ + + L Q Sbjct: 828 QQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQEL 887 Query: 1179 YVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ------- 1231 H + A R + ++Q + + E LQ Q ++ + + +LQ Sbjct: 888 MQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMV 947 Query: 1232 --NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASD 1289 + + + + L Q + ++ Q+Q+++ +++ M T KA+E + Sbjct: 948 AVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGI-- 1005 Query: 1290 VDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349 ++ QE L +L +L G S ++ L ERI Q L E Sbjct: 1006 ----LSRRLQEALAAKEAADAELGQLRAQGGS----SDSSLALHERI-------QALEAE 1050 Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409 S S L + E E + Q+ E + V+ L + +QE R RK++ Sbjct: 1051 LQAVSHSKTLLEKELQEVIALT---SQELEESREKVLE-------LEDELQESRGFRKKI 1100 Query: 1410 EESIKTNEKLRKQLERQGSEFV---QGSTSIFASGSELHSSLTSEIHFLRKQNQALNAML 1466 + ++N+KL +LE + + Q + ++ S L ++L L + N + A+L Sbjct: 1101 KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVL 1160 Query: 1467 IKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEV 1526 + K++E+ +++ + SLE + + S+KE+ + E RH Sbjct: 1161 ----QRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRH-------F 1209 Query: 1527 RCSGQELSRVQEEVKLRQQLLSQ 1549 + + ELS V++E++ ++ L+ + Sbjct: 1210 KAASLELSEVKKELQAKEHLVQK 1232 Score = 52.4 bits (124), Expect = 4e-06 Identities = 162/789 (20%), Positives = 298/789 (37%), Gaps = 97/789 (12%) Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKV--------SV 1094 Q Y ++ + P D L PS K DVL + A + + + +V S Sbjct: 339 QDTPYMVNGQEIPADTLGQFPSIK----DVLQ-AAAAEHQDQGQEVNGEVRSRRDSICSS 393 Query: 1095 MGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQ 1154 + + S + + LK+K+ LE +LE Q K +A + L AQ Sbjct: 394 VSLESSAAETQEEMLQVLKEKMR-LEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQ 452 Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID-SRVLENLKQQLEEQEYKL 1213 S + S + + SS +V +K + L M D +LE L L Sbjct: 453 VECS---HSSQQRQDSLSS--EVDTLK--QSCWDLERAMTDLQNMLEAKNASLASSNNDL 505 Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQH 1273 Q + +L +++ ++Q +D Q A + LQ+ Q++ R Sbjct: 506 QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLE---------RTT 556 Query: 1274 MNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM 1333 + + +KA + + + V + +Q+QL E +L+ + + V TQ L+ Sbjct: 557 LTSKLKASQAEISSLQ---SVRQWYQQQLALAQEARVRLQGEMAH---IQVGQMTQAGLL 610 Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393 E ++ +N++ L E+ S ++ D + ++ Sbjct: 611 EHLKLENVSLSQQLTETQHRSMKE--KGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEE 668 Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSE---LHSSLTS 1450 L ++E R+RL+ + L +QLE+ +Q + A E L LT Sbjct: 669 DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTL 728 Query: 1451 EIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRK-TVSLEHLQREYASVKEENERLQ 1509 L+ + Q+L+A+ + + + E+ SR+ T+ L LQ E ++ + + Sbjct: 729 TQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICL--LQNEKIILEAALQAAK 786 Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDE 1569 E +R ++L + + + L +++EE+ ++ Q + L Q K +K+ E Sbjct: 787 SGKEELDRGARRLEEGTEETSETLEKLREELAIKS---GQVEHLQQETAALKKQMQKIKE 843 Query: 1570 EHRRLR-DGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTP 1628 + + + + Y ++ + L +A + SE L L G T+ Sbjct: 844 QFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKEL----RQELMQVHGEKRTAEA 899 Query: 1629 CVSRL-------------VTGHHLWASK--------------NGRHVLGLIEDYEALLKQ 1661 +SRL + GH A K + ++ + E EAL KQ Sbjct: 900 ELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQ 959 Query: 1662 I----SQGQRLLAEMDIQTQEAPSS-TSQELGTKGPHPA------PLSKFVSSVSTAKLT 1710 I + ++ + E + + S TS + K H A LS+ + AK Sbjct: 960 IEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK-- 1017 Query: 1711 LEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLL--Q 1768 E A L L D LH E+I ++AE+ + EK+LQ + L + Sbjct: 1018 -EAADAELGQLRAQGGSSDSSLALH-ERIQALEAELQAVSHSKTLLEKELQEVIALTSQE 1075 Query: 1769 LSKRQEKVI 1777 L + +EKV+ Sbjct: 1076 LEESREKVL 1084 Score = 47.0 bits (110), Expect = 2e-04 Identities = 197/1128 (17%), Positives = 423/1128 (37%), Gaps = 180/1128 (15%) Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600 S E + EE++QVLK++ + L E+ +AEL A Sbjct: 395 SLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA---------- 444 Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660 L L+ Q+ ++ SL S+ + C + L++ ++DL Sbjct: 445 ---LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD--------------LERAMTDL 487 Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720 +++ N L + DL ++A + L+A ED + +D+ Sbjct: 488 QNMLE---AKNASLASSNNDL------------QVAEEQYQRLMAKVEDMQRSMLSKDNT 532 Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780 ++ L Q +++ + + L+ ++++IS + + Sbjct: 533 VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS---------------LQSVRQW 577 Query: 781 FNEKATLLLESRPDLLKVVRELLLGQL-------FLTEQEVS-GEHLDGKTEKTPKQKGE 832 + ++ L E+R L + + +GQ+ L + VS + L ++ K+KG Sbjct: 578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGR 637 Query: 833 LVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE 892 + +Q L EA ++ E + +D + EG+ R + A Sbjct: 638 IAAQLQGIEADM------LDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSA 691 Query: 893 AWEEKPINTA-LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNM 951 A E+ + L+ R + L + L+ +T +EA +SR Sbjct: 692 ASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLT-QEALQSR-------------E 737 Query: 952 YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQP 1011 L A Q +LQ+++ ELQGE + L + I+ EA ++ + + L Sbjct: 738 QSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG-- 795 Query: 1012 PVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071 A + G ++ +T + + + S Q + ++ + KE + Sbjct: 796 ----ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQ----MQKIKE--QF 845 Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHD----LETELEGYQ 1127 + V Y + +S + + + E ++H E EL Sbjct: 846 LQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLH 905 Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187 + Q+++H + EG K ++ + + L +++ K + Sbjct: 906 REVAQVRQH----------MADLEGHLQSAQKERDEME------THLQSLQFDKEQMVAV 949 Query: 1188 PLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRD-------LSPP 1240 A E + ++ E ++ + + QK + L L S ++ K + LS Sbjct: 950 TEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRR 1009 Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA-SDVDYCVAEGFQ 1299 ++L +A + L + + + G ++ ++ I+A E LQA S + + Q Sbjct: 1010 LQEALAAKEAADAELGQLRAQGGSSDSSLA---LHERIQALEAELQAVSHSKTLLEKELQ 1066 Query: 1300 EQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDN----LTYQHLLPESPEPSA 1355 E + ++ LE+ + L + E + ++R+EE N L +H + Sbjct: 1067 EVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQ 1126 Query: 1356 SHA-LSDYETSEKSFFSRDQKQ--DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEES 1412 S+A L ++ + ++ ++ + + +V+ +D M+H+ ++ L+ LE+ Sbjct: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHL--VQALQASLEKE 1184 Query: 1413 IKTNEKLRKQLERQGSEFVQGSTSIFASG---SELHSSLTSEIHFLRKQNQALNAMLIKG 1469 + L++Q+ E A+ SE+ L ++ H ++K + + I+ Sbjct: 1185 KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244 Query: 1470 SRDKQKE-----------------NDKLRESLSRKTVSLEHLQ----------REYASVK 1502 + Q+ +L E LS++ V + ++ RE S+K Sbjct: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304 Query: 1503 EENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ----LLSQNDKLLQSLR 1558 ++ + +++G ++ QQL+Q V+ EL QE++ + Q+ L ++ +L +++ Sbjct: 1305 QQLDLTEQQGRKELEGLQQLLQNVK---SELEMAQEDLSMTQKDKFMLQAKVSELKNNMK 1361 Query: 1559 VELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETP 1606 L+ ++L + RR + + + S SS TP + + P Sbjct: 1362 TLLQQNQQLKLDLRRGAAKTRKEPKGEAS-----SSNPATPIKIPDCP 1404 Score = 43.5 bits (101), Expect = 0.002 Identities = 72/375 (19%), Positives = 164/375 (43%), Gaps = 31/375 (8%) Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120 + F +I L++ N L L + + G + ++N L+ L+ L +R Sbjct: 1094 RGFRKKIKRLEESNKKLALEL--------EHEKGKLTGLGQSNAALREHNSILETALAKR 1145 Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK---RILLLEKDVTAAQAE 177 E L++ + V+++ + E +++K VQ ++ L K ++ L++ V AA+ E Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKH----LVQALQASLEKEKEKVNSLKEQVAAAKVE 1201 Query: 178 L---EKAFAGTETEKA-LRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233 + F E + ++ L++K ++K+ + + + + I + + L Sbjct: 1202 AGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEA 1261 Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQ 293 A +Q L+++ + + V + E+ L ++KERE ++ + + + ++ Sbjct: 1262 RAQLQLLQKQLDEQLSK-QPVGNQEMENL-KWEVDQKEREIQSLKQQLDLTEQQGRKELE 1319 Query: 294 ALEEDLR--EKEREIATEKKNSLKRDK-AIQGLTMALKSKEKKVEELNSEIE-KLSAAFA 349 L++ L+ + E E+A E + ++DK +Q LK+ K + + N +++ L A Sbjct: 1320 GLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAA 1379 Query: 350 KAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS 409 K R+ + + S + T + + A + L + + +K + L Sbjct: 1380 KTRK-----EPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVS-KEPLKNLNSCLQ 1433 Query: 410 DLQQERERLEKDLEE 424 L+QE + L++ +EE Sbjct: 1434 QLKQEMDSLQRQMEE 1448 >gi|32698688 citron [Homo sapiens] Length = 2027 Score = 96.7 bits (239), Expect = 2e-19 Identities = 142/623 (22%), Positives = 294/623 (47%), Gaps = 83/623 (13%) Query: 66 QITELKKENFNLKLRIYFLEERMQQEFHGPTE--HIYKTNIELKVEVESLKRELQEREQL 123 + +L+K N +L+I L+E++++ TE + + + K E +LQ RE Sbjct: 623 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRED- 681 Query: 124 LIKASKAV-ESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF 182 +S+ + + L EA E++ +A+ Q +E L ++ E+ + +++K Sbjct: 682 ---SSEGIRKKLVEA--EELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDL 736 Query: 183 AGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEE--LKLSLKSKEALIQCL 240 A ET + + R E + E K+ AM +D K R +E+ ++LS +K A L Sbjct: 737 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 796 Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALE-EDL 299 +++ M +E +S ELR +++ ET+A ++E Q + EE+++ + +D Sbjct: 797 FTQRN-MKAQEEMIS--ELR------QQKFYLETQAGKLEAQNRK--LEEQLEKISHQDH 845 Query: 300 REKEREIATE---KKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356 +K R + E ++ SL+ ++ L L + ++E S++ L AA A L+ Sbjct: 846 SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 905 Query: 357 KAQTQEFQGSEDYETALSGKEALSA----------ALRSQNLTKSTENHRLRRSIKKITQ 406 +A+T+ + + + E + +AL+A ALR+ + T T+ L + ++T+ Sbjct: 906 QAKTELEETTAEAEEEI---QALTAHRDEIQRKFDALRN-SCTVITD---LEEQLNQLTE 958 Query: 407 ELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLS 466 + ++L + L K L+EA S + I LR+EV+ LR E+ ERE + ++ +++ + Sbjct: 959 DNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 1014 Query: 467 ESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDL-------EVIQQNCYLMAAEDLELR 519 +EQV+ E+ N D LL+K + + E Q C + + + Sbjct: 1015 LKTTCTMLEEQVMD--LEALN--DELLEKERQWEAWRSVLGDEKSQFECRVRELQRM--- 1067 Query: 520 SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINN 579 L TEK S+ + S++ + + E ++L +Q + +K+ SD +N+ Sbjct: 1068 ---LDTEK-QSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLND 1123 Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEE 639 L+ + + + L+Q + + + L++ L E+ ++++++ + L++ Sbjct: 1124 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD----------------LQK 1167 Query: 640 NNRFQVEHFSQEELKKKVSDLIQ 662 N+ F++ QE L + +DL++ Sbjct: 1168 NHIFRLTQGLQEALDR--ADLLK 1188 Score = 73.9 bits (180), Expect = 1e-12 Identities = 124/576 (21%), Positives = 241/576 (41%), Gaps = 81/576 (14%) Query: 160 LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDE 218 + K++L+ K++ +Q + K E E RL ++SE++ + + ++ + + Sbjct: 447 MEKKLLIKSKELQDSQDKCHKM----EQEMT---RLHRRVSEVEAVLSQKEVELKASETQ 499 Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278 + L ++L + +L + L++ + +++ D+ L RE+ + E + Sbjct: 500 RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQ-----LLHDIREQSRKLQEIKE 554 Query: 279 MEHQKERNSFEERIQALEEDL--------------------REKEREIATEKKNSLKRDK 318 E+Q + + LEEDL E+ + ATE ++ L + K Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAK 614 Query: 319 AIQG---------LTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369 QG L ++ K++EL ++EK A +A E LQ + + + + Sbjct: 615 D-QGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 673 Query: 370 ETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS-DLQQERERLEKDLEEAHRE 428 E L +E S +R + L ++ E R + Q L L+Q+ + E+ ++ + Sbjct: 674 E-KLQNREDSSEGIR-KKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQ 731 Query: 429 KSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTEST-- 486 K L N +++ E +E+ K + + K++++ + K+ + EQ I L+E+ Sbjct: 732 IKKDLADKETLENMMQRHEEEAHEKGKILSEQ-KAMINAMDSKIRSLEQRIVELSEANKL 790 Query: 487 -------NQKDVLLQKFNEKDLEVIQQNCYL-MAAEDLELRSEGL--ITEKCSSQQPPGS 536 Q+++ Q+ E E+ QQ YL A LE ++ L EK S Q Sbjct: 791 AANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848 Query: 537 KTIFSKE---KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDS-INNLQAELNKIFALRK 592 + E ++ S ++EE LK++ T L SLQE +S + LQA AL Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQ---LTELQLSLQERESQLTALQAAR---AALES 902 Query: 593 QLEQDVLSYQNLRKTLEEQISEIRRREEE----------SFSLYSDQTSYLSICLEENNR 642 QL Q + EE+I + +E S ++ +D L+ E+N Sbjct: 903 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 962 Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678 ++F + + S + +L ++ HL++ I Sbjct: 963 LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREI 998 Score = 69.7 bits (169), Expect = 2e-11 Identities = 102/435 (23%), Positives = 186/435 (42%), Gaps = 47/435 (10%) Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108 E A+N K E Q+ ++ ++ + K R+ LE R+++ EH + +ELK Sbjct: 820 ETQAGKLEAQNRK-LEEQLEKISHQDHSDKNRLLELETRLREV---SLEH-EEQKLELKR 874 Query: 109 EVESLKRELQEREQLLIK---ASKAVESLAEAGGSEIQRVKEDARKKVQQV---EDLLTK 162 ++ L+ LQERE L A A+ES +E++ +A +++Q + D + + Sbjct: 875 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR 934 Query: 163 RILLLEKDVTAAQAELEKAFAGTETEKALRLR---LESKLSEMKKMHEGDLAMALVLDEK 219 + L T E+ TE L + L +L E ++ + + +D Sbjct: 935 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 994 Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMA--CPDENVSSGELRGLCAAPREEKERETEAA 277 R I E ++ L S++ ++ LK + + D + EL EKER+ EA Sbjct: 995 RREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELL--------EKERQWEAW 1046 Query: 278 QMEHQKERNSFEERIQAL------EEDLREKEREIATEKKN----SLKRDKA-IQGLTMA 326 + E++ FE R++ L E+ R + + TE + ++K KA I L A Sbjct: 1047 RSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQA 1106 Query: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386 LK ++ K E L+ ++ L + + A+ + + Q + E L + L + Q Sbjct: 1107 LKEQKLKAESLSDKLNDL-----EKKHAMLEMNARSLQQKLETERELK-QRLLEEQAKLQ 1160 Query: 387 NLTKSTENH--RLRRSIKKITQELSDLQQERERLEKDLEEAH----REKSKGDCTIRDLR 440 +NH RL + +++ L+ ER LE LE EK K + TI Sbjct: 1161 QQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQT 1220 Query: 441 NEVEKLRNEVNEREK 455 ++ L+ ++++ K Sbjct: 1221 KLIDFLQAKMDQPAK 1235 Score = 57.8 bits (138), Expect = 1e-07 Identities = 76/346 (21%), Positives = 140/346 (40%), Gaps = 54/346 (15%) Query: 62 DFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE 121 D E Q+ +L ++N L + ++L +++ E G + I ++L+ EV+ L+RE+ ERE Sbjct: 948 DLEEQLNQLTEDNAELNNQNFYLSKQLD-EASGANDEI----VQLRSEVDHLRREITERE 1002 Query: 122 QLLIKASKAVESLA-----------------------------------------EAGGS 140 L + +E+L E Sbjct: 1003 MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVR 1062 Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLS 200 E+QR+ + ++ + + +T+ ++E V +AE+ + +K L KL+ Sbjct: 1063 ELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 1122 Query: 201 EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA-LIQCLKEEKSQMACPDENVSSG-E 258 +++K H A L +K ELK L ++A L Q + +K+ + + + + Sbjct: 1123 DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD 1182 Query: 259 LRGLCAAPREEKERETEAAQMEHQKERNSFEERIQ---ALEEDLREKEREIATEKKNSLK 315 L R + E + E Q+ + E+ E I L + L+ K + A +KK Sbjct: 1183 RADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS 1242 Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361 R K L + + EL +EK A A+ EALQK + + Sbjct: 1243 RRKEDPALPTQV---PLQYNELKLALEKEKARCAELEEALQKTRIE 1285 Score = 52.0 bits (123), Expect = 5e-06 Identities = 165/763 (21%), Positives = 300/763 (39%), Gaps = 131/763 (17%) Query: 465 LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLI 524 L +S K H EQ + L ++ + +L + E +L+ + L+ +DL I Sbjct: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ-KEVELKASETQRSLLE-QDLAT----YI 511 Query: 525 TEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLK--KEQDIYTHLVKSLQESDSINNLQA 582 TE CSS + +++ + S + ++ +Q+L +EQ + LQE QA Sbjct: 512 TE-CSSLK----RSLEQARMEVSQEDDKALQLLHDIREQS------RKLQEIKE-QEYQA 559 Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642 ++ ++ + QLE+D++S + E ++ E R EE F + + + + ++ + Sbjct: 560 QVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE-FKRKATECQHKLLKAKDQGK 618 Query: 643 FQVEHFS----------------QEELKKKV---SDLIQLVKELYTDNQHLKKTIFDLSC 683 +V ++ QE+L+K V ++ +L++ + + ++ + L Sbjct: 619 PEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQN 678 Query: 684 MGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQ-----SNEIMKD 738 G +L E+ E K E + + +QH ++ N+I KD Sbjct: 679 REDSSEGIRKKLVEAEELE---EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 735 Query: 739 LS-KGGCKNGYLRHTESKISDCDGAHAPGCL--EEGAFINLLAPLFNEKATLLLE-SRPD 794 L+ K +N RH E AH G + E+ A IN + ++E S + Sbjct: 736 LADKETLENMMQRHEEE-------AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 788 Query: 795 LL----------------KVVRELLLGQLFLTEQ----EVSGEHLDGKTEKTPKQ----K 830 L +++ EL + +L Q E L+ + EK Q K Sbjct: 789 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848 Query: 831 GELVHF-VQTNSFSKPHDELKLSCEAQLVK---AGEVPKVGLKDASVQTVATEGDLLRFK 886 L+ + S H+E KL + QL + + + + L A E L + K Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 908 Query: 887 ---HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIK 943 E T EA EE TA HR E + A S IT+ E +L L + Sbjct: 909 TELEETTAEAEEEIQALTA----HRDEIQR---KFDALRNSCTVITDLE---EQLNQLTE 958 Query: 944 PSRSLGN--------MYRLPATQEVVTQLQSQILELQGELKEFK---TCNKQLHQKL--- 989 + L N + + + QL+S++ L+ E+ E + T KQ + L Sbjct: 959 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 1018 Query: 990 --ILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSY 1047 +L E VM+ D+ L + A++ G++K + +D+++Q Sbjct: 1019 CTMLEEQVMDLEALNDELLEKERQ--WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRA 1076 Query: 1048 EIDSEICPPDDLASLPSCKENPEDVLSPTSV-------ATYLSSKSQPSAKVSVMGTDQS 1100 D I + L + KE+ ++L+ A LS K K M + Sbjct: 1077 RADQRITESRQVVEL-AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNA 1135 Query: 1101 ESINTSNETE-YLKQKIHD----LETELEGYQNFIFQLQKHSQ 1138 S+ ETE LKQ++ + L+ +++ +N IF+L + Q Sbjct: 1136 RSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ 1178 Score = 48.9 bits (115), Expect = 4e-05 Identities = 112/553 (20%), Positives = 210/553 (37%), Gaps = 87/553 (15%) Query: 1086 SQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIIT 1145 ++ K+ + +++ S E L Q I + E + +LQ SE I Sbjct: 632 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE---RELEKLQNREDSSEGIRK 688 Query: 1146 VLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL-GPLAPEMIDSRVLENLKQ 1204 L E ++ + + + E+ Q Y + +K+L + ++ D LEN+ Q Sbjct: 689 KLVEAEELEEKHREAQVSAQHLEVHLKQKEQ-HYEEKIKVLDNQIKKDLADKETLENMMQ 747 Query: 1205 QLEEQEYK----LQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260 + EE+ ++ L +++ + + S+I +L+ + +LS +A +L+ Sbjct: 748 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS----------EANKLAANSS-- 795 Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320 + ++++M + EL Q A + Q + E LEK+ + K Sbjct: 796 -------LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848 Query: 1321 SVGVEMNTQ-NELMERIEEDNLTYQHLLPE---SPEPSASHALSDYETSEKSFFSRDQKQ 1376 + +E+ T+ E+ EE L + L E S + S L+ + + + S+ ++ Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ-LTALQAARAALESQLRQA 907 Query: 1377 DNETEKTSVMVNSFSQ-------------DLLMEHIQEIRTLRKRLEESIKTNEKLRKQ- 1422 E E+T+ Q D L I L ++L + + N +L Q Sbjct: 908 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQN 967 Query: 1423 --LERQGSEFVQGSTSIFASGSE---LHSSLTSEIHFLRKQNQALNA------MLIKGSR 1471 L +Q E + I SE L +T L Q Q + A ML + Sbjct: 968 FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 1027 Query: 1472 DKQKENDKLRES--------------LSRKTVSLEHLQREYASVKEENERLQKEGSEKER 1517 D + ND+L E S+ + LQR + K+ R + +E + Sbjct: 1028 DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 1087 Query: 1518 HNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQ--ND-------------KLLQSLRVELK 1562 + ++E + L + +E KL+ + LS ND L Q L E + Sbjct: 1088 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE 1147 Query: 1563 AYEKLDEEHRRLR 1575 ++L EE +L+ Sbjct: 1148 LKQRLLEEQAKLQ 1160 Score = 48.5 bits (114), Expect = 6e-05 Identities = 95/460 (20%), Positives = 173/460 (37%), Gaps = 78/460 (16%) Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQ------------- 1247 +LK+ LE+ ++ +E + +QL +I K +++ Y + V+ Sbjct: 516 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDL 575 Query: 1248 -SQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDV------DYCVAEGFQ- 1299 S R L ++++ + + + + +LL+A D +Y E Sbjct: 576 VSARRRSDLYESELRESR---LAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINA 632 Query: 1300 EQLNQCAELLEKLEK----------LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349 EQ + EL EKLEK L N + + E ++ E+ + + L E Sbjct: 633 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVE 692 Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL---------LMEHIQ 1400 + E H + + QK+ + EK V+ N +DL + H + Sbjct: 693 AEELEEKHREAQVSAQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEE 751 Query: 1401 EIRTLRKRLEES---IKTNEKLRKQLERQGSEF-----VQGSTSIFASG---------SE 1443 E K L E I + + LE++ E + ++S+F SE Sbjct: 752 EAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISE 811 Query: 1444 LHSS---LTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSR-KTVSLEHLQREYA 1499 L L ++ L QN+ L L K S + ++L E +R + VSLEH + + Sbjct: 812 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEH-EEQKL 870 Query: 1500 SVKEENERLQKEGSEKERH-------NQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDK 1552 +K + LQ E+E L ++R + EL E + Q L+ + Sbjct: 871 ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 930 Query: 1553 LLQ----SLRVELKAYEKLDEEHRRLRDGDKYPMESDNSF 1588 +Q +LR L+E+ +L + D + + N + Sbjct: 931 EIQRKFDALRNSCTVITDLEEQLNQLTE-DNAELNNQNFY 969 Score = 38.1 bits (87), Expect = 0.078 Identities = 89/415 (21%), Positives = 156/415 (37%), Gaps = 53/415 (12%) Query: 1389 SFSQDLLMEHIQEIRTLRKRLEESIKTN-----EKLRKQLERQGSEFVQGSTSIFASGSE 1443 S D ++ + +IR ++L+E + E++R + + + V SE Sbjct: 529 SQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE 588 Query: 1444 LHSSLTSEIHFLRKQNQALNAMLIKGSRDKQK--ENDKLRESLSRKTVSLEHLQREYASV 1501 L S + F RK + + +L + K + E KL + + + + ++ LQ + Sbjct: 589 LRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKA 648 Query: 1502 ----KEENERLQKEGSEKERHNQQL--IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555 E E LQ KER ++L +Q S + + + E + ++ + Q Sbjct: 649 VKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQ 708 Query: 1556 SLRVELKAYEKLDEEHRRLRDG-------DKYPMESDNSFDLFDSSQAVTPKSVSETPPL 1608 L V LK E+ EE ++ D DK +E N + K +SE + Sbjct: 709 HLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE--NMMQRHEEEAHEKGKILSEQKAM 766 Query: 1609 SGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRL 1668 N DS ++L L+ +N ++ E ++ ++ Q Q+ Sbjct: 767 I-NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRN-------MKAQEEMISELRQ-QKF 817 Query: 1669 LAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPE 1728 E EA + +E L K + K L E RL+ VSL Sbjct: 818 YLETQAGKLEAQNRKLEE---------QLEKISHQDHSDKNRLLELETRLR---EVSLE- 864 Query: 1729 DGQCPLHCEQIGEMKAEVTKLHKKLFEQEKK---LQNTMKLLQLSKRQEKVIFDQ 1780 H EQ E+K ++T+L L E+E + LQ L+ RQ K ++ Sbjct: 865 ------HEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 913 >gi|42794779 myosin 18A isoform b [Homo sapiens] Length = 2039 Score = 96.7 bits (239), Expect = 2e-19 Identities = 117/564 (20%), Positives = 247/564 (43%), Gaps = 57/564 (10%) Query: 90 QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEI-QRVK-E 147 Q+ E K EL++ + L+ + E L ES ++ +E +R++ E Sbjct: 1264 QQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAE 1323 Query: 148 DARKKVQQVEDLLTKRILLLEKDVTAAQ----AELEKAFAGTETEKALRLRLESKLSEM- 202 K++Q D L K++ ++E +V A+ AE+ + RL+ E + E+ Sbjct: 1324 KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVD 1383 Query: 203 --KKMHEGDLAMALVLDEK-----DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255 KK + + L ++++ +R + +L+ + + +Q LK+ K Q + + Sbjct: 1384 FTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKK-KCQRLTAELQDT 1442 Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA--LEEDLREKEREIATEKKNS 313 L G ++ + E E Q E + E Q L+ + ++E+++ + S Sbjct: 1443 KLHLEG-----QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497 Query: 314 LK-----RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED 368 LK +D I G T + S E ++++++S+ K A+ AK ++ L+ + + +D Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV----KD 1553 Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKK--------ITQELSDLQQERERLEK 420 E L + L L E R+R++ K + + Q++ +++E Sbjct: 1554 QEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1613 Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480 LEE + +K K R+L ++ L ++VN R+ E R + L + L + + ++ Sbjct: 1614 QLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLD 1673 Query: 481 HLTESTNQKDVLLQKFNEKD-------LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533 HL S K + Q N+ + V + + EDL L+ + + K + ++ Sbjct: 1674 HLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEE- 1732 Query: 534 PGSKTIFSKEKKQ-----SSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF 588 + +EK + D E++ +++KK + + L + IN+LQA+L + Sbjct: 1733 --QLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ---INDLQAQLEEAN 1787 Query: 589 ALRKQLEQDVLSYQNLRKTLEEQI 612 +++L++ + + Q+ + LE+ + Sbjct: 1788 KEKQELQEKLQALQSQVEFLEQSM 1811 Score = 82.4 bits (202), Expect = 4e-15 Identities = 149/672 (22%), Positives = 270/672 (40%), Gaps = 128/672 (19%) Query: 83 FLEERMQQEFHGPTEHIYKTNIELKVEVESL-KRELQEREQLLIKASKAVESLAEAGGSE 141 F ++R+QQEF E K+EVE KR+L+ R L +A E Sbjct: 1384 FTKKRLQQEF------------EDKLEVEQQNKRQLERRLGDL-----------QADSEE 1420 Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLE-KDVTAAQAELEKAFAGTETEKALRLRLESKLS 200 QR + +KK Q++ L L LE + V + E ++ +E +A KL Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480 Query: 201 EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260 K E D+ +A LK L+ K+ I ++ + +++SS E + Sbjct: 1481 REKLQREKDMLLAEAF--------SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532 Query: 261 GLCAAPREEKE-RETEAAQMEHQKERNSFEERIQALEE-DLR---EKEREIATEKKNSLK 315 + + +K+ R+ EA + ++E + IQ LE+ LR E ER T K Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592 Query: 316 RDKAIQGLTMALKSKEKKVE-ELNSEIEKLSAAFAKAREALQKAQT-------QEFQGSE 367 RD+ ++ + + K K++E +L E E + RE K T ++F+ + Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652 Query: 368 DYETALSGKEAL--SAALRSQNLTKSTENHRLRRSIKKITQELSDLQ-------QERERL 418 L +AL A L +L S + +R I ++ +L + + + R+ + Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPS---KREIAQLKNQLEESEFTCAAAVKARKAM 1709 Query: 419 EKDLEEAH-------REKSKGDCTIRDLRNEVEKLRNEVNEREKAME---NRYKSLLSES 468 E ++E+ H + K+ + + L+ E +++N + E ++ M ++K+ ++++ Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769 Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFN--EKDLEVIQQNCYLMAAEDLELRSEGLITE 526 ++ L + L E+ +K L +K + +E ++Q+ M + L R E I E Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---MVDKSLVSRQEAKIRE 1826 Query: 527 KCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNK 586 +T E+ Q E L LK+ + K +E D + Sbjct: 1827 ---------LETRLEFERTQVKRLESLASRLKENME------KLTEERD---------QR 1862 Query: 587 IFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVE 646 I A ++ EQ+ + LR T +E++ E+ R+E E+ Sbjct: 1863 IAAENREKEQNKRLQRQLRDT-KEEMGELARKEAEASR---------------------- 1899 Query: 647 HFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLAS 706 + EL+ + L + L D + K I DL D + S E +L+ S Sbjct: 1900 --KKHELEMDLESLEAANQSLQADLKLAFKRIGDLQA------AIEDEMESDENEDLINS 1951 Query: 707 KEDEDTIKIGED 718 + D D ED Sbjct: 1952 EGDSDVDSELED 1963 Score = 63.2 bits (152), Expect = 2e-09 Identities = 84/436 (19%), Positives = 183/436 (41%), Gaps = 41/436 (9%) Query: 267 REEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMA 326 ++E+ ++ + + +KERN LE + E E+ E+ + + T Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAE 1318 Query: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKA---QTQEFQGSEDYETALSGKEAL--SA 381 EK+++EL ++ + L + +A + E G D + A G+ L Sbjct: 1319 RLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA-GGEWRLKYER 1377 Query: 382 ALRSQNLTKSTENHRL-------RRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDC 434 A+R + TK +++ +++ + L DLQ + E ++ L++ ++ + Sbjct: 1378 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA 1437 Query: 435 TIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLL- 493 ++D + +E + +E EK + R+ S LS+++++ ++ + L +KD+LL Sbjct: 1438 ELQDTKLHLEGQQVRNHELEK-KQRRFDSELSQAHEEAQREKLQREKL---QREKDMLLA 1493 Query: 494 ------QKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547 Q+ EKD+++ + LE + + S Q + +K KKQ Sbjct: 1494 EAFSLKQQLEEKDMDIAG---FTQKVVSLEAELQDI------SSQESKDEASLAKVKKQL 1544 Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQ------ESDSINNLQAELNKIFALRKQLEQDVLSY 601 D E ++ ++E D ++ L+ E + Q ++ + +++E+ S Sbjct: 1545 RDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSC 1604 Query: 602 QNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLI 661 Q K +E Q+ E +++ + L+ ++ NR E S++ L+K + Sbjct: 1605 QKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE--SEKRLRKDLKRTK 1662 Query: 662 QLVKELYTDNQHLKKT 677 L+ + HLK + Sbjct: 1663 ALLADAQLMLDHLKNS 1678 Score = 52.0 bits (123), Expect = 5e-06 Identities = 123/666 (18%), Positives = 256/666 (38%), Gaps = 135/666 (20%) Query: 953 RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPP 1012 +L Q+ QL+ ++ +LQ + +E + +QL +K A ++ T L+ + Sbjct: 1396 KLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD------TKLHLEGQ 1449 Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDV 1072 ++ +++ S + + + Q+ + + ++ + + +E D+ Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDI 1509 Query: 1073 LSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQ 1132 T L ++ Q + S D++ + L+ K+ D E EL+ I Sbjct: 1510 AGFTQKVVSLEAELQDIS--SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567 Query: 1133 LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPE 1192 L+ +A + + E + SK D EE+ + + +K +++ L E Sbjct: 1568 LE------QAKLRLEMEMERMRQTHSKEMESRD-EEVEEARQSCQKKLKQMEV--QLEEE 1618 Query: 1193 MIDSRVLENLKQQLE---------------EQEYKLQKEQNLNMQLFSEIHNLQNKFRDL 1237 D + + K++LE E E +L+K+ L ++ + + ++ Sbjct: 1619 YEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678 Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEEL-LQASDVDYCVAE 1296 +P + RE++ + Q+++ C + + M E+L LQ D+ Sbjct: 1679 APSK---------REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT- 1728 Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSAS 1356 +EQL++ +NE+ R+EED L+ Sbjct: 1729 ALEEQLSRL--------------------QREKNEIQNRLEEDQEDMNELM--------- 1759 Query: 1357 HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTN 1416 +K V S+DL +I L+ +LEE+ K Sbjct: 1760 ------------------------KKHKAAVAQASRDLA-----QINDLQAQLEEANKEK 1790 Query: 1417 EKLRKQLERQGS--EFVQGST---SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSR 1471 ++L+++L+ S EF++ S S+ + L + + F R Q + L ++ + Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKE 1850 Query: 1472 DKQK---ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRC 1528 + +K E D+ + +R+ + LQR+ KEE L ++ +E R +L ++ Sbjct: 1851 NMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL-- 1908 Query: 1529 SGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELK-AYEKLDEEHRRLRDGDKYPMESDNS 1587 + L + N QSL+ +LK A++++ + + D MESD + Sbjct: 1909 ---------------ESLEAAN----QSLQADLKLAFKRIGDLQAAIED----EMESDEN 1945 Query: 1588 FDLFDS 1593 DL +S Sbjct: 1946 EDLINS 1951 Score = 47.0 bits (110), Expect = 2e-04 Identities = 68/319 (21%), Positives = 149/319 (46%), Gaps = 32/319 (10%) Query: 400 SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMEN 459 S ++I + ++QQ R +LEK A +E+++ L + + +L +E+ + E+ Sbjct: 1252 SEEQIRNKDEEIQQLRSKLEK----AEKERNELRLNSDRLESRISELTSELTDERNTGES 1307 Query: 460 RYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR 519 + L +E+ ++L + K + E Q D L ++ ++EV++ A + E+ Sbjct: 1308 ASQLLDAETAERLRAE----KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVD 1363 Query: 520 SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINN 579 + E + + F+K++ Q ++E+ ++V ++ + + LQ +DS + Sbjct: 1364 DDDAGGEWRLKYERAVREVDFTKKRLQ-QEFEDKLEVEQQNKRQLERRLGDLQ-ADSEES 1421 Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEE 639 +A + L+K+ ++ Q+ + LE Q ++R E E D S LS EE Sbjct: 1422 QRA----LQQLKKKCQRLTAELQDTKLHLEGQ--QVRNHELEKKQRRFD--SELSQAHEE 1473 Query: 640 NNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699 R E +E+L+++ L+ E ++ Q L++ D++ GF ++ S E Sbjct: 1474 AQR---EKLQREKLQREKD---MLLAEAFSLKQQLEEKDMDIA-------GFTQKVVSLE 1520 Query: 700 -QTELLASKEDEDTIKIGE 717 + + ++S+E +D + + Sbjct: 1521 AELQDISSQESKDEASLAK 1539 Score = 45.4 bits (106), Expect = 5e-04 Identities = 86/421 (20%), Positives = 164/421 (38%), Gaps = 59/421 (14%) Query: 1399 IQEIRTLRKRL----EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSS---LTSE 1451 ++E+ +KRL E+ ++ ++ ++QLER+ + S + +L LT+E Sbjct: 1379 VREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAE 1438 Query: 1452 IHFLR---KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERL 1508 + + + Q N L K R E + E R+ + E LQRE + E L Sbjct: 1439 LQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSL 1498 Query: 1509 QKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYE--- 1565 +++ EK+ Q+V EL + + + L++ K L+ L ++K E Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEEL 1558 Query: 1566 ---------------KLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSG 1610 +L+ E R+R MES + ++ ++ Q+ K L Sbjct: 1559 DEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE-EVEEARQSCQKKLKQMEVQLEE 1617 Query: 1611 NDTDSLSC------DSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL---LKQ 1661 D G AT + V+R K+ + L+ D + + LK Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKN 1677 Query: 1662 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKF---VSSVSTAKLTLEEAYRRL 1718 + +R +A++ Q +E+ + + + + + + ++ AK LEE RL Sbjct: 1678 SAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRL 1737 Query: 1719 ---KLLWRVSLPED---------------GQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1760 K + L ED Q QI +++A++ + +K+ E ++KL Sbjct: 1738 QREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKL 1797 Query: 1761 Q 1761 Q Sbjct: 1798 Q 1798 Score = 37.0 bits (84), Expect = 0.17 Identities = 43/197 (21%), Positives = 92/197 (46%), Gaps = 26/197 (13%) Query: 1391 SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450 S++ + +EI+ LR +LE++ K +LR +R S SEL S LT Sbjct: 1252 SEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRI-----------SELTSELTD 1300 Query: 1451 EIHFLRKQNQALNAMLI------KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504 E + +Q L+A K ++ Q + D L++ + + + +E ++ E Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM--EVMEMEVMEARLIRAAEI 1358 Query: 1505 NERLQKE--GSEKERHNQQLIQEVRCSGQELSR-VQEEVKLRQQLLSQNDKLLQSLRVE- 1560 N + + G E ++ ++EV + + L + ++++++ QQ Q ++ L L+ + Sbjct: 1359 NGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADS 1418 Query: 1561 ---LKAYEKLDEEHRRL 1574 +A ++L ++ +RL Sbjct: 1419 EESQRALQQLKKKCQRL 1435 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.310 0.127 0.343 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 67,118,131 Number of Sequences: 37866 Number of extensions: 3167238 Number of successful extensions: 33720 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 448 Number of HSP's successfully gapped in prelim test: 1340 Number of HSP's that attempted gapping in prelim test: 13783 Number of HSP's gapped (non-prelim): 10687 length of query: 1814 length of database: 18,247,518 effective HSP length: 117 effective length of query: 1697 effective length of database: 13,817,196 effective search space: 23447781612 effective search space used: 23447781612 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.