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Search of human proteins with 58535453
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58535453 CDK5 regulatory subunit associated protein 2
isoform b [Homo sapiens]
(1814 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 3533 0.0
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 3413 0.0
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 226 2e-58
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 226 2e-58
gi|71061468 centromere protein E [Homo sapiens] 134 6e-31
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 130 9e-30
gi|50658075 phosphodiesterase 4D interacting protein isoform 3 [... 127 8e-29
gi|50658077 phosphodiesterase 4D interacting protein isoform 4 [... 120 2e-26
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 116 2e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 116 2e-25
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 115 4e-25
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 113 1e-24
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 113 1e-24
gi|55770834 centromere protein F [Homo sapiens] 111 7e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 110 1e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 110 1e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 110 1e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 110 1e-23
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 107 1e-22
gi|31982906 cingulin-like 1 [Homo sapiens] 105 5e-22
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 104 7e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 103 1e-21
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 103 2e-21
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 100 1e-20
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 100 1e-20
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 99 5e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 98 6e-20
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 98 6e-20
gi|32698688 citron [Homo sapiens] 97 2e-19
gi|42794779 myosin 18A isoform b [Homo sapiens] 97 2e-19
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 3533 bits (9162), Expect = 0.0
Identities = 1814/1814 (100%), Positives = 1814/1814 (100%)
Query: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
Sbjct: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
Sbjct: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
Query: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
Sbjct: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
Query: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
Sbjct: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
Sbjct: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
Sbjct: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
Sbjct: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
Sbjct: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
Sbjct: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
Sbjct: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
Query: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
Sbjct: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
Query: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
Sbjct: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
Query: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
Sbjct: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
Query: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
Sbjct: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
Query: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
Sbjct: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
Sbjct: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
Sbjct: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
Sbjct: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
Sbjct: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
Sbjct: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
Sbjct: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
Query: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
Sbjct: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
Query: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
Sbjct: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
Query: 1561 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS 1620
LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS
Sbjct: 1561 LKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDS 1620
Query: 1621 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP 1680
GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP
Sbjct: 1621 GSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP 1680
Query: 1681 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG 1740
SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG
Sbjct: 1681 SSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG 1740
Query: 1741 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG 1800
EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG
Sbjct: 1741 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELRPG 1800
Query: 1801 GAHPGTCSPSRPGS 1814
GAHPGTCSPSRPGS
Sbjct: 1801 GAHPGTCSPSRPGS 1814
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 3413 bits (8850), Expect = 0.0
Identities = 1780/1893 (94%), Positives = 1795/1893 (94%), Gaps = 79/1893 (4%)
Query: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
Sbjct: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
Sbjct: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
Query: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
Sbjct: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
Query: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
Sbjct: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
Sbjct: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
Sbjct: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
Sbjct: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
Sbjct: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
Sbjct: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
Sbjct: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
Query: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
Sbjct: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
Query: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
Sbjct: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
Query: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
Sbjct: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
Query: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
Sbjct: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
Query: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
Sbjct: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
Sbjct: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
Sbjct: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
Sbjct: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
Sbjct: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
Sbjct: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
Sbjct: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
Query: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
Sbjct: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
Query: 1501 VKEENERLQKEGSEKERHNQQLIQ--------------EVRCSGQELSR-------VQEE 1539
VKEENERLQKEGSEKERHNQQLIQ EV+ Q LS+ ++ E
Sbjct: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
Query: 1540 VKLRQQLLSQNDKL-----------------------LQSLRVEL--------------- 1561
+K ++L ++ +L +Q+LR++L
Sbjct: 1561 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
Query: 1562 ----KAYEKLDEEHRRL----------------RDGDKYPMESDNSFDLFDSSQAVTPKS 1601
+ EK E L DGDKYPMESDNSFDLFDSSQAVTPKS
Sbjct: 1621 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS 1680
Query: 1602 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ 1661
VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
Sbjct: 1681 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ 1740
Query: 1662 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL 1721
ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
Sbjct: 1741 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL 1800
Query: 1722 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL 1781
WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
Sbjct: 1801 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL 1860
Query: 1782 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1814
VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Sbjct: 1861 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1893
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
[Homo sapiens]
Length = 969
Score = 226 bits (575), Expect = 2e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
Query: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
Query: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
Score = 72.4 bits (176), Expect = 4e-12
Identities = 143/679 (21%), Positives = 281/679 (41%), Gaps = 125/679 (18%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
Query: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
Query: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
Query: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
Query: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
Query: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
Query: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCS 529
E I+ L +S + ++ Q EK ++ ++++N L A L S+ I+ + +
Sbjct: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIF 588
P G K+ Q S +Q+ +D T L + +E SI + +L+ +
Sbjct: 702 EVTPTG---CLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVA 749
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
L K+L +E++ + ++E ES S S +++ EE QV+
Sbjct: 750 GLEKEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAA 795
Query: 649 SQEELKKKVSDLIQLVKEL 667
E L + + L+K+L
Sbjct: 796 DMESLTRNIQIKEDLIKDL 814
Score = 47.8 bits (112), Expect = 1e-04
Identities = 82/412 (19%), Positives = 161/412 (39%), Gaps = 63/412 (15%)
Query: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
Query: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
Query: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
Query: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
L + QK +R ES +K S +H Q ++++
Sbjct: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
E LQ + + + E+R Q + + + ++QLL + +LLQ
Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
Score = 40.4 bits (93), Expect = 0.016
Identities = 83/397 (20%), Positives = 166/397 (41%), Gaps = 56/397 (14%)
Query: 1403 RTLRKRLEESIKTNEKLRKQL----ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458
RTL + L + K N L+ ++ ER ++ I+ EL + S L+ +
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 1459 NQALN--------------AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504
Q L+ A L + ++Q+E + + E L K ++ LQ E K E
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK---IQLLQEESRLAKNE 122
Query: 1505 NERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-EEVKLRQ--QLLSQNDKLLQSLRVEL 1561
R+ ++ N +L ++++ + V ++VK Q + L+Q DK ++ L L
Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
Query: 1562 KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK---SVSETPPLSGNDTDSLSC 1618
A E+L E+ R + + +E S ++ ++ + + + ET + +DS
Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 1619 DSGSSATSTPCVSRLV------TGHHL-WASKNGRHVLGLIEDYEALLKQISQGQRLLAE 1671
+ T ++++ + L A ++ + G I++ LK+ + + E
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN----LKETLKSRERETE 298
Query: 1672 MDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQ 1731
Q E + T +L + H + L + SS T+ A +++ LL D Q
Sbjct: 299 ELYQVIEGQNDTMAKL-REMLHQSQLGQLHSSEGTS-----PAQQQVALL-------DLQ 345
Query: 1732 CPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQ 1768
L C Q+ E+ KL + + ++E++L + + +Q
Sbjct: 346 SALFCSQL-----EIQKLQRVVRQKERQLADAKQCVQ 377
Score = 36.2 bits (82), Expect = 0.30
Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%)
Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
+ E+ + + ++ E E S + QDLL
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Query: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576
+ L+++L A E+L +E LR+
Sbjct: 812 KDLQMQLVDPEDIPAMERLTQEVLLLRE 839
Score = 34.7 bits (78), Expect = 0.87
Identities = 50/249 (20%), Positives = 102/249 (40%), Gaps = 38/249 (15%)
Query: 1372 RDQKQDNETEKTSVM-VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF 1430
+D+KQ + V +NS ++ L +E + + + E ++ +L ++ R
Sbjct: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
Query: 1431 VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK--------GSRDKQKEN----- 1477
++ + E + L+ ++ + K + + +K RDK+ E
Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
Query: 1478 ---DKLRESLSRKTVSLEHLQREYASVK-----EENERLQKEGSEKERHNQQLIQEVRCS 1529
++L E LSR+ L HL E S++ EE + QK S + QQ + + +
Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 1530 ----------------GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573
++L+ + E+K Q+ + D +Q+L+ LK+ E+ EE +
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 302
Query: 1574 LRDGDKYPM 1582
+ +G M
Sbjct: 303 VIEGQNDTM 311
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1
[Homo sapiens]
Length = 2346
Score = 226 bits (575), Expect = 2e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
Query: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
Query: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
Score = 150 bits (379), Expect = 1e-35
Identities = 151/513 (29%), Positives = 245/513 (47%), Gaps = 104/513 (20%)
Query: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG---STSIFASGSELHSSLT 1449
DLL EH+ EIR LR+RLEESI N++LR+QLE + + +G +++ ++ G E L
Sbjct: 1842 DLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLC 1901
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
+E LR+ N+ L A L SR+ +E + LRE+L L+ L++E K E ++L
Sbjct: 1902 NENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLL 1961
Query: 1510 KEGSEKERHNQQLIQEVRCSGQE--------LSRVQEEVKLRQQLLSQNDKLLQ------ 1555
++ EK++ +E R S QE L +Q++ + +QQL LQ
Sbjct: 1962 EDLREKQQEVLHFREE-RLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALY 2020
Query: 1556 -SLRVELKAYE--------------KLDEEHRRLRDGDKYPMESDNSFDLFDSSQ----- 1595
+ + LKAY L E R LR + ++ +N L Q
Sbjct: 2021 GNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGA 2080
Query: 1596 ---AVTPKSVSETPPLS----------------------GNDTDSLSCDSGSSAT---ST 1627
+++P S+++ P S G ++ +L S +S+T T
Sbjct: 2081 GKASLSPSSINQNFPASTDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSASSTPGSET 2140
Query: 1628 PCVSR-----------LVTGHHL--------WASKNGRHVLGLIEDYEALLKQISQGQRL 1668
P ++R + T L +A+K+GRHV+G I+DY AL +QI++G+ L
Sbjct: 2141 PIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIAEGKLL 2200
Query: 1669 LAEMDIQTQEAPSSTSQE------LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLW 1722
+ ++ + A S E LG+KG H + SS S LEE+ L + W
Sbjct: 2201 VKKIVSLVRSACSFPGLEAQGTEVLGSKGIH-----ELRSSTSALHHALEESASLLTMFW 2255
Query: 1723 RVSLPEDGQCPLHCEQIGE-MKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQ----EKVI 1777
R +LP P+ ++GE + E+ +L K+ +QE+ LQ+T + L+ + +Q E+ I
Sbjct: 2256 RAALPST-HIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFI 2314
Query: 1778 FDQLVVTHKILRKARGNLELRPGGAHPGTCSPS 1810
QL TH +L+KAR NLE++ A P C+P+
Sbjct: 2315 VSQLTRTHDVLKKARTNLEVKSLRALP--CTPA 2345
Score = 134 bits (336), Expect = 1e-30
Identities = 275/1354 (20%), Positives = 534/1354 (39%), Gaps = 188/1354 (13%)
Query: 107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILL 166
++E++ L+R ++++E+ L A + V+ EA E ++ KE + K Q+
Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQ-FVEAAAHESEQQKEASWKHNQE----------- 399
Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226
L K + Q EL+ + LR K +E++ + + L K++L++E
Sbjct: 400 LRKALQQLQEELQNK------SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
Query: 227 K----------LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
+ +L++ E L++ L++ A E + L +E ++
Sbjct: 454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 513
Query: 277 AQMEHQKER-----NSFEERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL 327
+ +H ER +S E +Q++E LR K E+ T + +++ +
Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Query: 328 KSKEKKVEEL-------NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALS 380
K +E +++L N E+E LSA L K + + +E+ L KE +
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATL------LCKLGPGQSEIAEELCQRLQRKERML 627
Query: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
L S K H + I+ + Q +S +QE + + L +A E++ +R
Sbjct: 628 QDLLSDR-NKQVLEHEME--IQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 684
Query: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
+ L ++ + E L + + Q T T ++DV + + D
Sbjct: 685 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 744
Query: 501 LEVIQ--QNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKK----QSSDYEELI 554
L+ + + A E+LEL ++ E+ S + +++ + +++ Q++D E L
Sbjct: 745 LDTVAGLEKELSNAKEELELMAK---KERESQMELSALQSMMAVQEEELQVQAADMESLT 801
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI-- 612
+ ++ ++D+ L L + + I ++ ++ LR+++ Q + +Q+
Sbjct: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
Query: 613 ---SEIRRREEESFSLYSDQTSYLSICL--------EENNRFQVEHFSQEELKKKVSDLI 661
+ R + +L +++ Y S+ E + QVE + L+ ++ ++
Sbjct: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV- 920
Query: 662 QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELL----ASKEDEDTIKIGE 717
L + L N+ + L+ +G G STE T+ + A + +K+
Sbjct: 921 -LGRSLERLNR-----LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974
Query: 718 DDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHT---------ESKISDCDGAHAPGCL 768
+ + + Q+ S C + H E + ++ + +
Sbjct: 975 EKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQI 1034
Query: 769 EEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL-DGKTEKTP 827
EE F ++ + + N +L LE+ EL +E GE + DG +
Sbjct: 1035 EEAGFSSV-SHIRNTMLSLCLENA--------EL---------KEQMGEAMSDGWEIEED 1076
Query: 828 KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKH 887
K+KGE++ V+T + E L E + ++ LK+A + L+
Sbjct: 1077 KEKGEVM--VETVVTKEGLSESSLQAEFRKLQGK------LKNAHNIINLLKEQLVLSSK 1128
Query: 888 EATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRS 947
E + E ++ + E L G PG E + P S
Sbjct: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQH--------QEEGNVTVRPFPRPQSLD 1180
Query: 948 LGNMYRLPATQ------------EVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAV 995
LG + + A Q + L L+ +L + K + L +KL+L+EA
Sbjct: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240
Query: 996 MEGRPTP---DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE 1052
+ + + +L + V + + + + + + E + ++ S E +
Sbjct: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300
Query: 1053 ICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY- 1111
+ + C E + L+S S+ + +G + + +E
Sbjct: 1301 NSLKEMVLMEGLCSEQGRR-------GSTLASSSERKPLENQLGKQEEFRVYGKSENILV 1353
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE--------GAQDGLSKPKNG 1163
L++ I DL+ +L+ I L+ + E G +G S P +
Sbjct: 1354 LRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEG-SSPHSV 1412
Query: 1164 SDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223
D +E S Y +P + + LE+L Q++ + E +L K L +L
Sbjct: 1413 PDEDEGWLSDGTGAFY----------SPGLQAKKDLESLIQRVSQLEAQLPKN-GLEEKL 1461
Query: 1224 FSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEE 1283
E+ + P +YDSL+Q QARELS RQ+I++G GIC + +H +K+FE+
Sbjct: 1462 AEELRSAS------WPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED 1515
Query: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEKL-EKLFLNG-----KSVGVE---MNTQNELME 1334
LL+++D+DY + + F+EQL Q ++L E+L KL G+E + EL E
Sbjct: 1516 LLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQE 1575
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368
+ + + L S PS+SHALSD S S
Sbjct: 1576 KEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSS 1609
Score = 72.4 bits (176), Expect = 4e-12
Identities = 143/679 (21%), Positives = 281/679 (41%), Gaps = 125/679 (18%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
Query: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
Query: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
Query: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
Query: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
Query: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
Query: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCS 529
E I+ L +S + ++ Q EK ++ ++++N L A L S+ I+ + +
Sbjct: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIF 588
P G K+ Q S +Q+ +D T L + +E SI + +L+ +
Sbjct: 702 EVTPTG---CLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVA 749
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
L K+L +E++ + ++E ES S S +++ EE QV+
Sbjct: 750 GLEKEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAA 795
Query: 649 SQEELKKKVSDLIQLVKEL 667
E L + + L+K+L
Sbjct: 796 DMESLTRNIQIKEDLIKDL 814
Score = 47.8 bits (112), Expect = 1e-04
Identities = 82/412 (19%), Positives = 161/412 (39%), Gaps = 63/412 (15%)
Query: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
Query: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
Query: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
Query: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
L + QK +R ES +K S +H Q ++++
Sbjct: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
E LQ + + + E+R Q + + + ++QLL + +LLQ
Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 458
Score = 45.4 bits (106), Expect = 5e-04
Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 37/236 (15%)
Query: 379 LSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRD 438
L++ R + T + + L SI ++ E L+++ RL+ L RE S+
Sbjct: 1876 LTSTARGRGSTSNFYSQGLE-SIPQLCNENRVLREDNRRLQAQLSHVSREHSQ------- 1927
Query: 439 LRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
E E LR E + +R S L E K+L +Q+ + L E +K + F E
Sbjct: 1928 ---ETESLR------EALLSSR--SHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
Query: 499 KDLEVIQQNCYLMAAEDLELRSE-GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVL 557
+ L +Q+N D L+ + L+ ++C +Q +F + + YE L
Sbjct: 1977 ERLS-LQEN-------DSRLQHKLVLLQQQCEEKQQ-----LFESLQSELQIYEALYGNS 2023
Query: 558 KKEQDIYT-HLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
KK Y+ + S +++L AE+ ALR QLEQ + LR L++Q+
Sbjct: 2024 KKGLKAYSLDACHQIPLSSDLSHLVAEVR---ALRGQLEQSIQGNNCLRLQLQQQL 2076
Score = 40.4 bits (93), Expect = 0.016
Identities = 83/397 (20%), Positives = 166/397 (41%), Gaps = 56/397 (14%)
Query: 1403 RTLRKRLEESIKTNEKLRKQL----ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458
RTL + L + K N L+ ++ ER ++ I+ EL + S L+ +
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 1459 NQALN--------------AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504
Q L+ A L + ++Q+E + + E L K ++ LQ E K E
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENK---IQLLQEESRLAKNE 122
Query: 1505 NERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-EEVKLRQ--QLLSQNDKLLQSLRVEL 1561
R+ ++ N +L ++++ + V ++VK Q + L+Q DK ++ L L
Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
Query: 1562 KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK---SVSETPPLSGNDTDSLSC 1618
A E+L E+ R + + +E S ++ ++ + + + ET + +DS
Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 1619 DSGSSATSTPCVSRLV------TGHHL-WASKNGRHVLGLIEDYEALLKQISQGQRLLAE 1671
+ T ++++ + L A ++ + G I++ LK+ + + E
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQN----LKETLKSRERETE 298
Query: 1672 MDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQ 1731
Q E + T +L + H + L + SS T+ A +++ LL D Q
Sbjct: 299 ELYQVIEGQNDTMAKL-REMLHQSQLGQLHSSEGTS-----PAQQQVALL-------DLQ 345
Query: 1732 CPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQ 1768
L C Q+ E+ KL + + ++E++L + + +Q
Sbjct: 346 SALFCSQL-----EIQKLQRVVRQKERQLADAKQCVQ 377
Score = 36.2 bits (82), Expect = 0.30
Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%)
Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
+ E+ + + ++ E E S + QDLL
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Query: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576
+ L+++L A E+L +E LR+
Sbjct: 812 KDLQMQLVDPEDIPAMERLTQEVLLLRE 839
Score = 35.4 bits (80), Expect = 0.51
Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 14/133 (10%)
Query: 278 QMEHQKERNSFEERIQALEEDLREKEREI---ATEKKNSLKRDKAIQG----LTMALKSK 330
++EHQK Q L EDLREK++E+ E+ + + D +Q L + K
Sbjct: 1949 ELEHQKVER------QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK 2002
Query: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
++ E L SE++ A + +++ L KA + + + LS A ALR Q
Sbjct: 2003 QQLFESLQSELQIYEALYGNSKKGL-KAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQS 2061
Query: 391 STENHRLRRSIKK 403
N+ LR +++
Sbjct: 2062 IQGNNCLRLQLQQ 2074
Score = 34.7 bits (78), Expect = 0.87
Identities = 50/249 (20%), Positives = 102/249 (40%), Gaps = 38/249 (15%)
Query: 1372 RDQKQDNETEKTSVM-VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF 1430
+D+KQ + V +NS ++ L +E + + + E ++ +L ++ R
Sbjct: 63 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNE 122
Query: 1431 VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK--------GSRDKQKEN----- 1477
++ + E + L+ ++ + K + + +K RDK+ E
Sbjct: 123 AARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSL 182
Query: 1478 ---DKLRESLSRKTVSLEHLQREYASVK-----EENERLQKEGSEKERHNQQLIQEVRCS 1529
++L E LSR+ L HL E S++ EE + QK S + QQ + + +
Sbjct: 183 AAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 1530 ----------------GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573
++L+ + E+K Q+ + D +Q+L+ LK+ E+ EE +
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQ 302
Query: 1574 LRDGDKYPM 1582
+ +G M
Sbjct: 303 VIEGQNDTM 311
Score = 34.7 bits (78), Expect = 0.87
Identities = 60/282 (21%), Positives = 117/282 (41%), Gaps = 35/282 (12%)
Query: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAP--------- 266
L E L + L+ S+ + L + L+ + A + S+ +GL + P
Sbjct: 1848 LGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVL 1907
Query: 267 REEKER---ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323
RE+ R + EH +E S E + + L+E E+E+ +K ++R + ++ L
Sbjct: 1908 REDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQK---VERQQLLEDL 1964
Query: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAR-----EALQKAQTQEFQGSEDYETALSGKEA 378
+EK+ E L+ E+LS +R LQ+ ++ Q E ++ L EA
Sbjct: 1965 ------REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
Query: 379 LSAALRSQNLTKSTENHRLRRSIK-KITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437
L N K + + L + ++ +LS L E L LE++ + +C
Sbjct: 2019 LYG-----NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ---GNNCLRL 2070
Query: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
L+ ++E + + ++ + + NK+L Q+ +
Sbjct: 2071 QLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV 2112
Score = 33.5 bits (75), Expect = 1.9
Identities = 37/149 (24%), Positives = 69/149 (46%), Gaps = 16/149 (10%)
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD-QTSYLSIC-- 636
L+ L +I LR++LE+ + LR+ LE +++ R + + YS S +C
Sbjct: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
Query: 637 ---LEENNR---FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690
L E+NR Q+ H S+E ++ S L + L + HL++ +L +
Sbjct: 1904 NRVLREDNRRLQAQLSHVSREHSQETES----LREALLSSRSHLQELEKELEHQKVERQQ 1959
Query: 691 FPDRLASTEQTELLASKEDEDTIKIGEDD 719
+ L +Q E+L +E+ + + E+D
Sbjct: 1960 LLEDLREKQQ-EVLHFREER--LSLQEND 1985
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 134 bits (338), Expect = 6e-31
Identities = 314/1537 (20%), Positives = 619/1537 (40%), Gaps = 240/1537 (15%)
Query: 140 SEIQRVKEDARKKVQQVEDLLTKR----ILLLEKDVTAAQAELEKAFAGTETEKALRLRL 195
SE+ ++ D V E L T++ + L EK+ LE+ +T+K ++L
Sbjct: 498 SELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALER-----KTKKDQEMQL 552
Query: 196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
++S +K + + + ++L+ L SK ++ L+E++ Q+ E +
Sbjct: 553 IHEISNLKNL----------VKHAEVYNQDLENELSSK---VELLREKEDQIKKLQEYID 599
Query: 256 SGELRGL----------CAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKERE 305
S +L + P++ K+ +A + +R S R + LE L+EK +E
Sbjct: 600 SQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE--LKEKMKE 657
Query: 306 IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQG 365
+AT K + + IQ L++K+K +L E++ K + ++
Sbjct: 658 LATTYK---QMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 366 SEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEA 425
+ + E ++ + + L K E + R + EL L E ERL K++++
Sbjct: 715 NLELEGKITDLQ--------KELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 426 HREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--------LSESNKKLHNQE- 476
E + + +E +KL +EV +E ++ + + ++SN K +QE
Sbjct: 767 SEE-------LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819
Query: 477 QVIKHLTESTNQKDVLLQKFNEK-DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPG 535
Q K L QK ++ + NE+ + E++ + A+ + L TE Q
Sbjct: 820 QNFKTLHMDFEQKYKMVLEENERMNQEIVNLS---KEAQKFDSSLGALKTELSYKTQELQ 876
Query: 536 SKTIFSKE--------KKQSSDYEELIQVLKKEQDIYTHL-------VKSL-QESDSINN 579
KT +E K+Q + + +Q +++E+ + T VK+L QE D +
Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI----SEIRRREEESFSLYSDQTSYLS- 634
LQ L R QL+ D+ N+ +EQ+ +++ +E +L S + +S
Sbjct: 937 LQESLQ---IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
Query: 635 -ICLEENNRFQVEHFSQEELK-KKVSDL----IQLVKELYTDNQHLK--KTIFDLSCMGF 686
+ +EEN + F Q+ + K DL Q + DN+ ++ + IF L
Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ--- 1050
Query: 687 QGNGFPDRLAST--EQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGC 744
+ N L S E+ +L ++ + I +E+ L D+ +Q + ++ +
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110
Query: 745 KNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLL 804
K G L T ++++ + EK+ L E + LL V E+
Sbjct: 1111 KEGELSRTCDRLAEVEEK------------------LKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 805 GQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVP 864
Q + E E L K + E + Q KL+ + VK+
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQ-----------KLNENYEEVKSITKE 1201
Query: 865 KVGLKDASVQTVATEGDLLRF---KHEATR-EAWEEKPINTALSAEHRP---ENLHGVPG 917
+ LK+ ++ TE D LR + EAT + EE I EH+ E V
Sbjct: 1202 RKVLKELQ-KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Query: 918 WQAALLSLPGITNREAK-KSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELK 976
A +++ + K + +P+L + L N+ + TQE + +L ++L Q K
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL--ELLTEQSTTK 1318
Query: 977 EFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRD 1036
+ T + ++L L E E + K+L + + K IK V D
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQ-EEIKSLTKERDNL-----------KTIKEALEVKHD 1366
Query: 1037 KEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMG 1096
+ + ++ +I + ++ KE + S K ++ +
Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNM---KEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 1097 TDQSESINTS-NETEYLKQKIHDLETELEGYQNFIFQLQ--------KHSQCSEAIITVL 1147
S+ + S +E + + ++ DL+ E Q+ QL+ KH + E +
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Query: 1148 CGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLE 1207
C + ++ +++ + +E S++ + LE + +L+
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTI---------------------QKQLEAINDKLQ 1522
Query: 1208 EQEYKL-QKEQNLNMQLFSEIHNLQNKFRDLSPPR--YDSLVQSQARELSLQRQQIKDGH 1264
+ ++ +KE+ N++ SE+ N+ + R DS +QS ++ ++++
Sbjct: 1523 NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE-- 1580
Query: 1265 GICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ-CAELLEKLEKLFLNGKSVG 1323
S++ + MIK EE+ + + + +E + A++ E EK + K
Sbjct: 1581 -----SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635
Query: 1324 V---------------EMNTQNELMERIEEDNLTYQHLLPESPEP--SASHALSDYETSE 1366
V + TQ +E IE +N+ +L E+ E S + D + E
Sbjct: 1636 VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVE 1695
Query: 1367 KSF-FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425
++ RDQ ++N E + ++DL E +E++ + L+E +T +KLR +
Sbjct: 1696 ETLKVERDQLKENLRE-------TITRDL--EKQEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
+ +E + S L + LR + L +++Q+ DKLR +S
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHL--------KEQQETIDKLRGIVS 1798
Query: 1486 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ 1545
KT L ++Q++ ++ N +LQ++ E + + QLI + + +V E +L++Q
Sbjct: 1799 EKTDKLSNMQKD---LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 1546 LLSQNDKL----LQSLRVELKAYEKLDEEHRRLRDGD 1578
+ Q+ L +++L + K +E L+E +++ D
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1892
Score = 125 bits (314), Expect = 4e-28
Identities = 300/1590 (18%), Positives = 642/1590 (40%), Gaps = 198/1590 (12%)
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
+H N +L+ E+ S L+E+E + K + ++S +++ +K D ++ +
Sbjct: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS------QKLENIKMDLSYSLESI 617
Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK---KMHEGDLAM- 212
ED + L + + A A+ E AF +E L L+ K+ E+ K E D+ +
Sbjct: 618 EDPKQMKQTLFDAETVALDAKRESAFLRSEN-----LELKEKMKELATTYKQMENDIQLY 672
Query: 213 ALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER 272
L+ K ++ +L+ L+S I L P + + + EL G ++E +
Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV-PKDLLCNLELEGKITDLQKELNK 731
Query: 273 ETEAAQMEHQK-----ERNSFEERIQALEEDLREKERE--IATEKKNSLKRDKAIQGLTM 325
E E + ++ E S ++ L +++++K E I T +K+ L +
Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE-------- 783
Query: 326 ALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRS 385
+ KE +V+ L EI K A ++ K+ QEFQ + K +
Sbjct: 784 -VVHKESRVQGLLEEIGKTKDDLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMVLE--- 838
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
EN R+ QE+ +L +E ++ + L E S +++ EV++
Sbjct: 839 -------ENERMN-------QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 446 LRNEVNEREKAMENRYKSLLSESNKK---LHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
NE+ + ++ +ENR +L + +K +Q ++ + T +KD L Q +E
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 503 ---------------VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
+ Q A E L+ E + T K + + ++
Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET 1004
Query: 548 SD-YEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA-------LRKQLEQDVL 599
D +++ + + K+QD+ ++L N + + KIF+ L++ LE +
Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA 1064
Query: 600 SYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSD 659
+ L+ L+E I +EE L + I +E N + ++++
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE 1124
Query: 660 LIQLVKE----LYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKI 715
+ + +KE L Q L ++S M + N + + EL + + +++
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184
Query: 716 GEDDEINFLSDQHLQQSNEIMKDLSKG-----GCKNGYLRHTES---------KISDCDG 761
+ N+ + + + +++K+L K GY+R E+ KI+
Sbjct: 1185 AQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHL 1244
Query: 762 AHAPGCLEE--GAFINLLAPLFN----EKATLLLESRPDLLKVVRELLLGQLFLTEQEVS 815
++E + A + N EK+ L+ +L +ELL ++E + +
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
Query: 816 GEHLDGKTEK------TPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVK----AGEVP 864
L+ TE+ T + E+ F + +E+K L+ E +K A EV
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 865 KVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLS 924
LK+ +T+A + + K E + E+ T + +E + +ALL
Sbjct: 1365 HDQLKEHIRETLAKIQE-SQSKQEQSLNMKEKDNETTKIVSE-----MEQFKPKDSALLR 1418
Query: 925 LP----GITNR-EAKKSRLPILIKPSRSLGNMYRLPATQ-----EVVTQLQSQILELQGE 974
+ G++ R + + + K L + + ++ E + ++ ++ LE + E
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
Query: 975 LKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVW 1034
LK C K+ + + + + T T+ + Q+ E ++
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE---------IY 1529
Query: 1035 RDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENP-EDVLSPTSVATYLSSKSQPSAKVS 1093
+E + +Q S E+ ++ K++ + + S T +SQ ++
Sbjct: 1530 EKEEQFNIKQIS-EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 1094 VMGTDQSESINTS--NETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE 1151
+ ++ + + + E + LK+ ++ +++ Q +Q K + +E +C E
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET-QEKMCEIE 1647
Query: 1152 GAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR-VLENLKQQLEEQE 1210
++ K + E L Q+ + ++++ + + E D R V E LK + ++ +
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILH-ENLEEMRSVTKERDDLRSVEETLKVERDQLK 1706
Query: 1211 YKLQK--EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICV 1268
L++ ++L Q +I ++ K + + +V + E+S ++ +
Sbjct: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL-------- 1758
Query: 1269 ISRQHMNTMIKAFEELLQAS-DVDYCVAEGFQEQLNQCAELL-EKLEKLFLNGKSVGVEM 1326
+H N +KA + +Q + + + QE +++ ++ EK +KL K +
Sbjct: 1759 ---EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL---E 1812
Query: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
N+ +L E+I+E L+ + K + QK+ +E E+
Sbjct: 1813 NSNAKLQEKIQELKANEHQLI-----------------TLKKDVNETQKKVSEMEQLKKQ 1855
Query: 1387 VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHS 1446
+ S L I+ + L ++L E+++ + + K ER V+ + + +L
Sbjct: 1856 IKDQSLTLSKLEIENL-NLAQKLHENLEEMKSVMK--ERDNLRRVEETLKL--ERDQLKE 1910
Query: 1447 SL-TSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
SL ++ L Q + A ++ S++ ++ DKLRE +S KT+ + +Q++ K+E
Sbjct: 1911 SLQETKARDLEIQQELKTARML--SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDEL 1968
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE-EVKLRQQLLSQNDKLLQSLRVELKAY 1564
++ +E +KE ++ ++V S ++++ +++ + + Q LS + + ++ K +
Sbjct: 1969 QKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028
Query: 1565 EKLDE---------EHRRLRDGDKYPMESD 1585
E L+E E RR+++ K ME D
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLK--MERD 2056
Score = 102 bits (255), Expect = 3e-21
Identities = 338/1700 (19%), Positives = 677/1700 (39%), Gaps = 264/1700 (15%)
Query: 56 RARNMKDFENQITELKK--ENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESL 113
+ R +++ N++ +LK+ EN + L+ E+ + E T KT + K +++ L
Sbjct: 878 KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 114 KRELQ-EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK------RILL 166
+ LQ ER+QL V + +++ E ++ + + L +K R L
Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHE---GDLAMALVLDEKDRLI 223
+E++ + E ++ G + ++ L + L+ K +E + ++ EK+ L
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 224 EELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH-- 281
+ L+ + KE L LKE +M ++ ELR L +K++E A + H
Sbjct: 1057 QMLESVIAEKEQLKTDLKEN-IEMTIENQE----ELRLL--GDELKKQQEIVAQEKNHAI 1109
Query: 282 --QKERNSFEERIQALEEDLREKEREIATEKKNSL----------KRDKAIQGLTMALKS 329
+ E + +R+ +EE L+EK +++ +++ L K+ I+ L LK+
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKN 1169
Query: 330 KEKKVEELNSEIEKLSA----------AFAKAREALQKAQTQEFQGSEDY---------E 370
KE +E + +E +L+ + K R+ L++ Q + F+ D+
Sbjct: 1170 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ-KSFETERDHLRGYIREIEA 1228
Query: 371 TALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQEL---SDLQQERERLEKDLEEAHR 427
T L KE L A + T + LRRS+ + T ++ DL++ +L++++ H
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDE-LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287
Query: 428 EKS-----KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHL 482
E+ K ++ NE+E L + ++ R + N+K ++ IK L
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 483 T----------ESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQ- 531
T E+ K L++ + L IQ++ + L ++ + T K S+
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES-QSKQEQSLNMKEKDNETTKIVSEM 1406
Query: 532 ---QPPGSKTI------FSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
+P S + K+ ++E+ V K++ D+ ++ + +S+S + L+
Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL--QRLQEVLQSES-DQLKE 1463
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR-RREEESFSLYSDQTSYLSICLEENN 641
+ +I A + E+++ K EE I+E+R E+ + + Q +I + N
Sbjct: 1464 NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN 1523
Query: 642 RFQVEHFSQEELK-KKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
+ Q + +E+ K++S++ + V EL +H K L + + +RL +++
Sbjct: 1524 KIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQE 1583
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKN-GYLRHT---ESKI 756
+ KE E+ ++ E +I DQ + + EI+ + + K +L+ T E++
Sbjct: 1584 EIQIMIKEKEEMKRVQEALQIE--RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641
Query: 757 SDCDGAHAPGCLE---------EGAFINLLAPLFN--EKATLLLESRPDL------LKVV 799
C+ H E E I L L E+ + + R DL LKV
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 800 RELLLGQLFLT-------EQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLS 852
R+ L L T ++E+ H+ K + K + +TN S +L+ S
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENL 912
+A +KA +D +Q + LR H +E E + L
Sbjct: 1762 NDA--LKA--------QDLKIQ------EELRIAHMHLKEQQE------------TIDKL 1793
Query: 913 HGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQ 972
G+ + LS ++ + S + K N ++L ++ V + Q ++ E++
Sbjct: 1794 RGIVSEKTDKLS---NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 973 GELKEFK----TCNK----------QLHQKLILAEAVMEGRPT---PDKTLLNAQPPVGA 1015
K+ K T +K +LH+ L ++VM+ R ++TL + +
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910
Query: 1016 AYQDSPGE----QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
+ Q++ Q+ +KT + ++ + D+ R + I D L K+
Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE--- 1967
Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTS----NETEYLKQKIHDLETELEGYQ 1127
L K Q K + E +N S NE E LK++ ++ +
Sbjct: 1968 ----------LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017
Query: 1128 NFIFQLQK--HSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF-SSLHQVRYVKHVK 1184
FQL K H E I +D L + K E F ++L ++ + +
Sbjct: 2018 MDNFQLTKKLHESLEEIRIVA-----KERDELRRIKESLKMERDQFIATLREM--IARDR 2070
Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
+ PE R+L + +Q L E L+++ + +L + + + L+ D
Sbjct: 2071 QNHQVKPE---KRLLSDGQQHLTE---SLREKCSRIKELLKRYSEMDDHYECLNRLSLDL 2124
Query: 1245 LVQSQ-ARELSLQRQQIKDGHGICVISRQHMNTMIKA-------FEELLQASDVDYCVAE 1296
+ + +ELS+ ++K + + +H+ + A F +++
Sbjct: 2125 EKEIEFQKELSM---RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181
Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSAS 1356
+E+ + E + K E F++ E+ Q EL+ +I QHL + P S
Sbjct: 2182 KIKEEQH---ESINKFEMDFID------EVEKQKELLIKI-------QHLQQDCDVP--S 2223
Query: 1357 HALSDYETSEK---------SFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRK 1407
L D + ++ FS + +TE V+ N +E R +
Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE 2283
Query: 1408 RLEESI-KTNEKLRK----------QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR 1456
+L+ I K N+++ + + + +EF + S +I + SL + L
Sbjct: 2284 KLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF 2343
Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSL--EHLQREYASVKEENERLQKEGSE 1514
K Q L L G++ D ++ + L E ++ S+ E E
Sbjct: 2344 KNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKE----SAMH 2399
Query: 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL----KAY-EKLDE 1569
KE ++ +E+ + ++++Q +V + L + + +Q L+ ++ K Y E++++
Sbjct: 2400 KESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459
Query: 1570 EHRRLRDGDKYPMESDNSFD 1589
+L D M++ F+
Sbjct: 2460 LKMKLVKIDLEKMKNAKEFE 2479
Score = 100 bits (248), Expect = 2e-20
Identities = 157/775 (20%), Positives = 329/775 (42%), Gaps = 112/775 (14%)
Query: 44 LPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTN 103
L + E ++ NMK+ +N+ T++ E K + L R++ E G ++ + +++
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESH 1434
Query: 104 IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
E+K V K +LQ +++L S ++ + +KE K ++ E+L
Sbjct: 1435 DEMK-SVAKEKDDLQRLQEVLQSESDQLK----------ENIKEIVAKHLETEEELKVAH 1483
Query: 164 ILLLEKDVTAAQAELEKAFAGTETE------KALRLRLESKLSEM-KKMHEGDLAMALVL 216
L E++ T + + + TE +A+ +L++K+ E+ +K + ++ +
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543
Query: 217 DEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
EK +++ K K+K++ +Q ++ + ++ R ++ +E
Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELT-----------------NRLQESQEEIQ 1586
Query: 277 AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE 336
++ ++E +E +Q + L+E +EI + K S +++ +T +++EK
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM--- 1643
Query: 337 LNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAA---LRSQNLTKSTE 393
EIE L F + L+ +T+ + ++ L +++ LRS T E
Sbjct: 1644 --CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 394 NHRLRRSIKK-ITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE 452
+L+ ++++ IT++L + Q+E + + L+E H+E TI LR V + NE++
Sbjct: 1702 RDQLKENLRETITRDL-EKQEELKIVHMHLKE-HQE------TIDKLRGIVSEKTNEISN 1753
Query: 453 REKAMENRYKSLLSESNK----------KLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
+K +E+ +L ++ K L Q++ I L ++K L +KDLE
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM-QKDLE 1812
Query: 503 VIQQNCYLM-AAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQ 561
N L ++L+ LIT K + + + KKQ D + L+ E
Sbjct: 1813 --NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
Query: 562 -DIYTHLVKSLQESDSI------------------NNLQAELNKIFALRKQLEQDVLSYQ 602
++ L ++L+E S+ + L+ L + A +++Q++ + +
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930
Query: 603 NLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELK-------- 654
L K +E + ++R + E SD L +E + +++ ++EL+
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK-KIQELQKKELQLLRVKEDV 1989
Query: 655 ----KKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL-ASTEQTELLASKED 709
KK++++ QL K+ N ++ D FQ +L S E+ ++A + D
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMD----NFQ---LTKKLHESLEEIRIVAKERD 2042
Query: 710 E-----DTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
E +++K+ D I L + + K +G TES C
Sbjct: 2043 ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
Score = 68.9 bits (167), Expect = 4e-11
Identities = 157/756 (20%), Positives = 296/756 (39%), Gaps = 160/756 (21%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117
+ +KD +++L+ EN NL +++ E M+ +++ + LK+E + LK L
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK-ERDNLRRVEETLKLERDQLKESL 1912
Query: 118 QE---REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAA 174
QE R+ + + K L++ + +++E +K Q+ D+ +KD+ +
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI--------QKDLDKS 1964
Query: 175 QAELEKAFAGTETEKALRLRLES-------KLSEM------------------------- 202
+ EL+K + ++ LR++ K++EM
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Query: 203 KKMHEGDLAMALVLDEKDRLIEELKLSLK-SKEALIQCLKE-----EKSQMACPDENVSS 256
KK+HE + +V E+D L +K SLK ++ I L+E ++ P++ + S
Sbjct: 2025 KKLHESLEEIRIVAKERDEL-RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083
Query: 257 GELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK- 315
+ L + RE+ R E ++ E + E + L DL E+EI +K+ S++
Sbjct: 2084 DGQQHLTESLREKCSRIKEL--LKRYSEMDDHYECLNRLSLDL---EKEIEFQKELSMRV 2138
Query: 316 ---------RDKAIQGLTMA----------------------LKSKEKKVEELNS----- 339
+ K I+ L A K KE++ E +N
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 340 --EIEKLSAAFAKAREALQKAQTQEFQGSE---DYETALSGKEALSAALRSQNLTKSTEN 394
E+EK K + Q + + + L +E L S+ + TE
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEF 2258
Query: 395 HRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDL-RNEVEKLRNEVNER 453
++ + K++TQ L + R +EK L+ ++++ C + + N + + NE E
Sbjct: 2259 QQVLSNRKEMTQFLEEWLNTRFDIEK-LKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2317
Query: 454 E-------KAMENRYKSLLSESNKKLHNQEQVIK-------------------HLTESTN 487
E K E KSL E N+KL Q +K H+T
Sbjct: 2318 EERSATISKEWEQDLKSL-KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT 2376
Query: 488 QKDVLLQKFNE--------------KDLEVIQQNCYLMAAEDLELRSEGLITE--KCSSQ 531
Q + +K E K+ ++I+ L D+ + + + E KC +
Sbjct: 2377 Q--LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434
Query: 532 QPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVK-SLQESDSINNLQAELNKIFA- 589
+ + K + Y+E I+ LK + LVK L++ + + E++ A
Sbjct: 2435 TKETIQVLQDKVALGAKPYKEEIEDLKMK------LVKIDLEKMKNAKEFEKEISATKAT 2488
Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQV---E 646
+ Q E L +NLR++ + Q + + + T + +N + + E
Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSE 2548
Query: 647 HFSQEE----LKKKVSDLIQLVKELYTDNQHLKKTI 678
H E+ LK++ LI+ EL ++NQHL +
Sbjct: 2549 HIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584
Score = 53.9 bits (128), Expect = 1e-06
Identities = 105/469 (22%), Positives = 189/469 (40%), Gaps = 87/469 (18%)
Query: 270 KERETEAAQMEHQKERNSFEERIQALEED-----LREKE--REIATEKKNSLKR---DKA 319
K E ++ Q E S E R QA+E+D L EK+ +++ EK +L R +
Sbjct: 346 KRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSS 405
Query: 320 IQGLTMALKSKEKK-----------------------VEELNSEIEKLSAAFAKAREALQ 356
L LK+K K+ + ++ KLS + +
Sbjct: 406 SLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESV 465
Query: 357 KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE 416
+++ F + D + + A + L +N+ +E + LR + + L+ E+E
Sbjct: 466 CSESDVFSNTLDTLSEIEWNPA-TKLLNQENI--ESELNSLRADYDNLVLDYEQLRTEKE 522
Query: 417 RLEKDLE--------EAHREKSKGDCTIRDLRNEVEKLRNEVNERE---KAMENRYKS-- 463
+E L+ EA K+K D ++ L +E+ L+N V E + +EN S
Sbjct: 523 EMELKLKEKNDLDEFEALERKTKKDQEMQ-LIHEISNLKNLVKHAEVYNQDLENELSSKV 581
Query: 464 -LLSE------------SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD---LEVIQQN 507
LL E ++KL N + + + ES + Q + + L+ +++
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641
Query: 508 CYLMAAEDLELR---SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIY 564
+L +E+LEL+ E T K ++ +KK D E+ +Q E
Sbjct: 642 AFL-RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 565 THLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---------KTLEEQISEI 615
T L+ D + NL+ E KI L+K+L ++V + LR K+L ++ +
Sbjct: 701 TSLIDGKVPKDLLCNLELE-GKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERL 759
Query: 616 RR----REEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
R+ + EE + S++ S + + +R Q EE+ K DL
Sbjct: 760 RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ---GLLEEIGKTKDDL 805
Score = 40.8 bits (94), Expect = 0.012
Identities = 88/419 (21%), Positives = 169/419 (40%), Gaps = 96/419 (22%)
Query: 347 AFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQ 406
+F + ALQ A T ++ + Y +S EAL R + + L++ +++++
Sbjct: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMD-------LKKQLEEVSL 364
Query: 407 ELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLS 466
E E+++L + LEE +DL ++K++NE E M SL
Sbjct: 365 ETRAQAMEKDQLAQLLEE------------KDL---LQKVQNEKIENLTRMLVTSSSLTL 409
Query: 467 ESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE 526
+ K + +V L + K+ N D I N IT
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKN-----SNYADQFNIPTN----------------ITT 448
Query: 527 KCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESD--------SIN 578
K K + E+ + + E D++++ + +L E + +
Sbjct: 449 K--------------THKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQE 494
Query: 579 NLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRR----EEESFSLYSDQTSYLS 634
N+++ELN +LR + VL Y+ LR EE +++ + E E+ + + +
Sbjct: 495 NIESELN---SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ 551
Query: 635 ICLEENN-RFQVEHFS--QEELKKKVSDLIQLVKEL---------YTDNQHLKKTIFDLS 682
+ E +N + V+H ++L+ ++S ++L++E Y D+Q L+ DLS
Sbjct: 552 LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611
Query: 683 CMGFQGNGFPDRLASTEQ-TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS 740
L S E ++ + D +T+ + E FL ++L + E MK+L+
Sbjct: 612 Y----------SLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKEKMKELA 659
Score = 38.9 bits (89), Expect = 0.046
Identities = 68/310 (21%), Positives = 128/310 (41%), Gaps = 58/310 (18%)
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
K+ IC ++ N +I E + + +++ +++ L L EK EKLF N +
Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS---LKEKNEKLFKNYQ 2347
Query: 1321 SV------GVEMNTQNE--------------LMERIEEDNLTYQHLLPESPEPSASHALS 1360
++ G ++N + E+I E ++ L E+ E SA H S
Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE----LENSLHEAKE-SAMHKES 2402
Query: 1361 DYETSEKSF------FSRDQKQDNET----EKTSVMVNSFSQDLLM---EHIQEIRTLRK 1407
+K ++ Q + +E+ EKT + + + + +EI L+
Sbjct: 2403 KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKM 2462
Query: 1408 RLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLI 1467
+L + K K+ E++ + + + E+ L LR+ QA + +I
Sbjct: 2463 KLVKIDLEKMKNAKEFEKE----ISATKATVEYQKEVIRLLREN---LRRSQQAQDTSVI 2515
Query: 1468 KGSRDKQKENDKLR----ESLSRKTVSL----EH--LQREYASVKEENERLQKEGSEKER 1517
D Q N L + + T +L EH L++E + +K++NE+L K+ +E
Sbjct: 2516 SEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLS 2575
Query: 1518 HNQQLIQEVR 1527
+NQ L EV+
Sbjct: 2576 NNQHLSNEVK 2585
Score = 38.5 bits (88), Expect = 0.060
Identities = 94/457 (20%), Positives = 181/457 (39%), Gaps = 92/457 (20%)
Query: 58 RNMKDFENQITELKKENFNL--KLRIYFLEE------------RMQQEFHGPTEHI--YK 101
+ +K + +T++K+E K + F++E +QQ+ P+ + K
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK 2230
Query: 102 TNIELKVEVESLKRELQERE---------QLLIKASKAVESLAEAGGS--EIQRVKEDAR 150
N + + +E + ++ E E Q+L + + L E + +I+++K +
Sbjct: 2231 LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQ 2290
Query: 151 K---KVQQVEDLLTKRILLL------------------EKDVTAAQAELEKAFAGTETEK 189
K ++ QV + RI+ + E+D+ + + + EK F +T K
Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLK 2350
Query: 190 ---ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSL-KSKEALIQCLKEEKS 245
A ++ + K H A L ++ I EL+ SL ++KE+ + KE K
Sbjct: 2351 TSLASGAQVNPTTQDNKNPHVTSRATQLTTEK----IRELENSLHEAKESAMH--KESKI 2404
Query: 246 QMACPDENVSSGELRGLCAAPRE-----EKERET-EAAQMEHQKERNSFEERIQALEEDL 299
+ V++ + L A E EK +ET + Q + ++E I EDL
Sbjct: 2405 IKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEI----EDL 2460
Query: 300 REKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQ 359
+ K +I EK + K EK++ + +E RE L+++Q
Sbjct: 2461 KMKLVKIDLEKMKNAKEF-------------EKEISATKATVEYQKEVIRLLRENLRRSQ 2507
Query: 360 TQEFQG--SEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERER 417
+ SE + S K + ++T+ L+ ++ +E+S L+Q+ E+
Sbjct: 2508 QAQDTSVISEHTDPQPSNKPLTCGG--GSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2565
Query: 418 LEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNERE 454
L K E + L NEV+ + +RE
Sbjct: 2566 LIKQKNELLSNN-------QHLSNEVKTWKERTLKRE 2595
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 130 bits (328), Expect = 9e-30
Identities = 344/1681 (20%), Positives = 661/1681 (39%), Gaps = 267/1681 (15%)
Query: 48 SEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK 107
SEE ++ + + K+ + EL K+ L+ R +E+M+ K + E K
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKK---LQTREREFQEQMKVALEKSQSEYLKISQE-K 529
Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167
+ ESL E E ++ KA+ + +E ++Q+ E R ++ ++E L K +
Sbjct: 530 EQQESLALEELELQK------KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583
Query: 168 E---KDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLD------ 217
+ KD+ A E EK + K + + +E +E++ + H+ D L
Sbjct: 584 KNQSKDL-AVHLEAEK----NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY 638
Query: 218 --EKDRLIE----ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAA------ 265
E ++L E E + LK KE + Q EE ++ +V EL L +
Sbjct: 639 QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 266 PREEKERETEAAQMEHQKERNSFEERIQALEEDLRE------KEREIATEKKNSLKRDKA 319
R + E E + + K + E ++ + ++ KE E++ ++ +D+
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ- 757
Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEAL 379
I L + LK ++K ++E + +E L A ++ LQ+A + + Y++A
Sbjct: 758 INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK-LDVFQSYQSA------- 809
Query: 380 SAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT---- 435
+ TK+ E + ++ Q+L DL+ ER L K + E +K K CT
Sbjct: 810 -----THEQTKAYEEQ-----LAQLQQKLLDLETERILLTKQVAEVEAQK-KDVCTELDA 858
Query: 436 ----IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTN---- 487
++DL ++EK +E+ ++ K++ Y+S L + NK+ QEQ + L E N
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE---QEQTKQILVEKENMILQ 915
Query: 488 -------QKDVLLQKFNEKDLEV-IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539
+ ++L QK + K+ + I Y ++ E + E + +K Q K +
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME-KVKQKAKEMQETLKKKL 974
Query: 540 FSKEKKQSSDYEE-LIQVLKKEQDIYTHLVKSLQE-----SDSINNLQA----ELNKIFA 589
+E K + E +++ +KE+ +++ Q SD+++ L+ ++ +
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 590 LRKQLEQDVLSY--QNLRKTLEE--QISEIRRREEESFSLYSDQTSYLSICLEENNRFQV 645
+ ++ DV+S + L + EE +I EI+ +E+E Q L C +E ++
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
Query: 646 EHFS-------------QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
QE+LK+K + + L ++ HL+K DL+
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN------KSLK 1148
Query: 693 DRLASTEQTELLASKEDEDTIKIGE--------DDEINFLSDQHLQQSNEIMKDLSKGGC 744
+ EQ L +ED K+ E D+E L H ++SN+ ++D S
Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH-EKSNKSLEDKSLEFK 1207
Query: 745 KNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLL 804
K + I C A + IN+ + N + + + KV LL+
Sbjct: 1208 KLSEELAIQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 805 GQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQ-TNSFSKPHDELKLSCEAQLVKAGEV 863
++E E L T +Q + F Q T+ + +++K
Sbjct: 1267 KTCTVSELEAQLRQL------TEEQNTLNISFQQATHQLEEKENQIK------------- 1307
Query: 864 PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALL 923
A ++++ TE + L+ + ++A EK + EN++ V
Sbjct: 1308 ----SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT------- 1356
Query: 924 SLPGITNREAKKSRLPI------LIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKE 977
+ E K+ ++ I L + L N L + ++ L+ Q E + EL
Sbjct: 1357 ----LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL-- 1410
Query: 978 FKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDK 1037
L Q L+ V T K ++A V + + E K K S + +
Sbjct: 1411 -------LDQVQDLSFKV----DTLSKEKISALEQVD-DWSNKFSEWKK-KAQSRFTQHQ 1457
Query: 1038 EMDSDQQRSYEIDS-EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMG 1096
+ Q E+ S E D+ +L + + ++ KS+ K S +
Sbjct: 1458 NTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE 1517
Query: 1097 TD-QSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQD 1155
T+ +S++ +++ QK ++E+ E +N + QK + E + + +
Sbjct: 1518 TELKSQTARIMELEDHITQKTIEIESLNEVLKN--YNQQKDIEHKELVQKL---QHFQEL 1572
Query: 1156 GLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV------LENLKQQLEEQ 1209
G K + EE + +QV +K E ++ V L+ L+ +LE +
Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632
Query: 1210 ------EYKLQKEQN---LNMQLFSEIHNLQNKFRDLSPPRYDSL---VQSQARELSLQR 1257
E K + EQ + QL S++ + +++ + L +Q + RE+ +
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 1258 QQIKDGHG----ICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE 1313
+++K ++ R N + A+ E +A D CV + ++E+++ L + E
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKN--VAAYTEQEEA-DSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 1314 KLFL-------NGKSVGVEMNTQ----------------------NELMERIEEDNLTYQ 1344
KL S EM Q L E +EE N Y
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 1345 HLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRT 1404
++ + E + + ++ F QK E E T ++ ++L +++
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
Query: 1405 LRKRLEESIKTNEKLRKQLERQG----SEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQ 1460
R +EE EKL+ + G +E ++ +T + + L S + Q+
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN---MEAQHN 1926
Query: 1461 ALNAMLIKGSRDKQKENDK-------LRESLSRKTVSLEHLQREYASVKEENERLQKEGS 1513
L L R+KQK + LR LE L++EY +EE + ++E
Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 1514 EKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRR 1573
E +HN L Q +R +L++ ++E++ ++ + + ++ VE + E EE +
Sbjct: 1987 EL-KHNSTLKQLMREFNTQLAQKEQELE-----MTIKETINKAQEVEAELLESHQEETNQ 2040
Query: 1574 L 1574
L
Sbjct: 2041 L 2041
Score = 105 bits (261), Expect = 5e-22
Identities = 301/1485 (20%), Positives = 591/1485 (39%), Gaps = 299/1485 (20%)
Query: 157 EDLLTKRILLLEKDVTAAQ---AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMA 213
++ L +R+ +E+ +++ + +EL A+ + EK + S+ + +L
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 214 LVLDE--KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKE 271
L +D+ K L EE SL+ K+ I L+ +Q++ + + +G + P + E
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQ---TQVSLLKQRLRNGPMNVDVLKPLPQLE 252
Query: 272 RETEAAQMEHQKERN--------SFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323
+ E E E + + + ++ L++ ++ +E + K+ + L
Sbjct: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLL 312
Query: 324 TMALKSKEKKVEELNSEIEKLS----AAFAKAREALQKA-----QTQEFQGSEDYETALS 374
T ++ +++++E E+EK+ A K L+ A Q ++ +G ET
Sbjct: 313 TSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372
Query: 375 GKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDC 434
E L K E +LR IK++T + +L++++E+ E+ A E K
Sbjct: 373 MHETLEM--------KEEEIAQLRSRIKQMTTQGEELREQKEKSER---AAFEELEKALS 421
Query: 435 TIRDLRNEVEKLRNEVNER----EKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490
T + KL+ E++E+ EK E SL E ++ +++V+ + +S+ ++
Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV---KQEVVDVMKKSSEEQI 478
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
LQK +EK+L R E +T+K +++ ++
Sbjct: 479 AKLQKLHEKEL----------------ARKEQELTKKLQTRE---------------REF 507
Query: 551 EELIQV-LKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLE 609
+E ++V L+K Q Y + + ++ +S+ + EL K A+ + E + Q +T
Sbjct: 508 QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK-KAILTESENKLRDLQQEAETYR 566
Query: 610 EQISEIRRREEESFSLYSDQTSYLSICLE-ENNRFQVE-HFSQEELKKKVSDLIQLVKEL 667
+I E+ E+S +Q+ L++ LE E N+ E E+ K ++ L L
Sbjct: 567 TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
+T+ + K + + E L K +++ + +D EI F
Sbjct: 627 WTEKLQVLKQQYQ------------------TEMEKLREKCEQEKETLLKDKEIIF--QA 666
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787
H+++ NE K L K K L S++S+ A LEE +++L +K
Sbjct: 667 HIEEMNE--KTLEKLDVKQTELESLSSELSEV--LKARHKLEEE--LSVLKDQ-TDKMKQ 719
Query: 788 LLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFV--QTNSFSKP 845
LE++ D K + + + + E EVS + +TEK K + + + + + K
Sbjct: 720 ELEAKMDEQKNHHQQQVDSI-IKEHEVSIQ----RTEKALKDQINQLELLLKERDKHLKE 774
Query: 846 HDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE---AWEEKPINTA 902
H + EA + ++ + +Q + + D+ + AT E A+EE+
Sbjct: 775 HQAHVENLEADIKRS---------EGELQQASAKLDVFQSYQSATHEQTKAYEEQ----L 821
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVT 962
+ + +L +L + EA+K ++V T
Sbjct: 822 AQLQQKLLDLE-----TERILLTKQVAEVEAQK----------------------KDVCT 854
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPG 1022
+L + +++Q +++ + N ++ QK+ V E + +D
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK-----------------LEDGNK 897
Query: 1023 EQKGIKTTSSVWRDKE-----MDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTS 1077
EQ + T + +KE M Q++ EI L S KE+ +L+
Sbjct: 898 EQ---EQTKQILVEKENMILQMREGQKKEIEI---------LTQKLSAKEDSIHILN-EE 944
Query: 1078 VATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETEL-EGYQNFIFQL-QK 1135
T ++ + KV + E+ LK+K+ D E +L + +N +L QK
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQET---------LKKKLLDQEAKLKKELENTALELSQK 995
Query: 1136 HSQCSEAIITVL-CGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMI 1194
Q + ++ + + G D +S+ + + + + +H+ E+
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--------------RELN 1041
Query: 1195 DSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
D V+ +++L +Q +LQ EIH +Q +Q + +E++
Sbjct: 1042 D--VISIWEKKLNQQAEELQ-----------EIHEIQ--------------LQEKEQEVA 1074
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL-- 1312
+Q+I + ++ MN I +E D QEQL Q + + L
Sbjct: 1075 ELKQKIL----LFGCEKEEMNKEITWLKEEGVKQDT---TLNELQEQLKQKSAHVNSLAQ 1127
Query: 1313 EKLFLNGKSVGVEMNTQNELMER-IEEDNLTYQHLLPESPEPSASHALSDYETSEKSF-- 1369
++ L +E++ L E ++ L +L E + S S +T+++ F
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 1370 -FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGS 1428
S +K + E S+ S++L ++ L+ K E L LE + +
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQ-----------LDICCKKTEAL---LEAKTN 1233
Query: 1429 EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGS---------RDKQKENDK 1479
E + S S+ ++ L+ H + + A+LIK R +E +
Sbjct: 1234 ELIN------ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 1480 LRESLSRKTVSLEHLQREYASVK-------EENERLQKEG-------SEKERHNQQLIQE 1525
L S + T LE + + S+K E E LQKEG SEKE QL +E
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 1526 VRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+ + ++ ++EE+K ++ +S K L L V+L+ L E+
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Score = 83.6 bits (205), Expect = 2e-15
Identities = 153/776 (19%), Positives = 327/776 (42%), Gaps = 133/776 (17%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123
E+ IT+LKKE + ++E ++++ KVE+ SL ++L +
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEK---------------KVEISSLSKQLTDLNVQ 1382
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183
L + E A A S ++ E+ + + QV+DL K L ++ ++A + + +
Sbjct: 1383 LQNSISLSEKEA-AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK 1441
Query: 184 GTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK-- 241
+E +K + R + +K++ + EKD I LK L + CLK
Sbjct: 1442 FSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGE 1501
Query: 242 --EEKSQMACPDENVSSGELRGLCAAPREEKERETEAA-----------------QMEHQ 282
++KS+M + N+ + EL+ A E ++ T+ +EH+
Sbjct: 1502 MEDDKSKMEKKESNLET-ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK 1560
Query: 283 K---ERNSFEE-------RIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEK 332
+ + F+E R++ EE + E ++ + K + K ++ + +++KSKE+
Sbjct: 1561 ELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEE 1620
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
+++ L +E SA AK E +KA+ + + + + KE + K T
Sbjct: 1621 ELKALEDRLESESA--AKLAELKRKAEQKIAAIKKQLLSQMEEKE--------EQYKKGT 1670
Query: 393 ENH--RLRRSIKKITQELSDLQQERERLEKDLEE------------AHREKSKGD---CT 435
E+H L +++ +E+ L+++ + +E E A+ E+ + D C
Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730
Query: 436 IRDLRNEVEKLRNEVNEREKAM----ENRYKSLLSESNKKLHNQEQVIK-HLTESTNQKD 490
+ ++ L+ + E+EK + + + +++ S + QE++IK E+ +D
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
+ +++LE + L+ A+ +E EG K + Q + +F +K +
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVE--KEG---GKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLE- 609
E Q+L+++ ++E DS Q E++++ ++E+ Y+ L+ +
Sbjct: 1846 ELTCQILEQK----------IKELDSCLVRQKEVHRV-----EMEELTSKYEKLQALQQM 1890
Query: 610 ----EQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKV-SDLIQLV 664
+ + EE + Q LS ++N + + E K+K+ ++++L
Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 665 KELYT----------------DNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE 708
K+L D + +K + + + N +L T+ LA KE
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQ-LAQKE 2009
Query: 709 DE------DTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISD 758
E +TI ++ E L + H +++N+++K +++ K+ L+ T + +
Sbjct: 2010 QELEMTIKETINKAQEVEAELL-ESHQEETNQLLKKIAE---KDDDLKRTAKRYEE 2061
Score = 70.9 bits (172), Expect = 1e-11
Identities = 286/1524 (18%), Positives = 584/1524 (38%), Gaps = 296/1524 (19%)
Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE--------- 452
KK+ Q++S+ QQ+ L++ L A + S T +R+ +++E
Sbjct: 3 KKLKQKISEEQQQ---LQQALAPA--QASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGD 57
Query: 453 ----------REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
R ++E+ ++S + ES + ++E +++ T+ ++ L N DL+
Sbjct: 58 TQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVR-----TSSRESL----NRLDLD 108
Query: 503 VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS---DYEELI---QV 556
D++ +E L+ S + + + E+ SS Y EL+ Q+
Sbjct: 109 --SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQM 166
Query: 557 LKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR 616
L++E+ ++ Q+ L +I LR++L+ D Q +K L+E+
Sbjct: 167 LQREKKKLQGILSQSQDKS--------LRRIAELREELQMD----QQAKKHLQEEFDASL 214
Query: 617 RREEESFSLYSDQTSYLSICLEENNRF------------QVEHFSQEELKKKVSDLI--- 661
+++ S+ Q S L L Q E F++EE + + +
Sbjct: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
Query: 662 -QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
VK L T Q +K+ + L ++T + S +++ T+ E +
Sbjct: 275 GTSVKTLETLQQRVKRQ--------------ENLLKRCKET--IQSHKEQCTLLTSEKEA 318
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
+ D+ LQ+ +I KDL ++ I+ A NL+ L
Sbjct: 319 LQEQLDERLQELEKI-KDL--------HMAEKTKLITQLRDAK-----------NLIEQL 358
Query: 781 FNEKATLLLESRPDLLKVV--RELLLGQLF--LTEQEVSGEHLDGKTEKTP--------- 827
+K ++ E++ + + + +E + QL + + GE L + EK+
Sbjct: 359 EQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEK 418
Query: 828 -------------KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQ 874
K K E+ ++T K +E ++S + +L + + +K +S +
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKT--IEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 875 TVAT-----EGDLLRFKHEAT-----REAWEEKPINTALSAEHRPENLHGVPGWQAALLS 924
+A E +L R + E T RE ++ + AL Q L+
Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536
Query: 925 LPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQ 984
L E + + IL + L ++ Q+ +++ILEL+ L++ NK
Sbjct: 537 L-----EELELQKKAILTESENKLRDL------QQEAETYRTRILELESSLEKSLQENKN 585
Query: 985 LHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIK-TTSSVWRDKEMDSDQ 1043
+ L + + + + T++ + E + +K ++W +K Q
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVM---------VEKHKTELESLKHQQDALWTEKLQVLKQ 636
Query: 1044 QRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESI 1103
Q E++ C++ E +L + + + + Q+E
Sbjct: 637 QYQTEMEK---------LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687
Query: 1104 NTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNG 1163
+ S+E + + H LE EL ++ Q K Q EA + + KN
Sbjct: 688 SLSSELSEVLKARHKLEEELSVLKD---QTDKMKQELEA-------------KMDEQKNH 731
Query: 1164 SDGEEMTFSSLHQVRYVKHVKILG------PLAPEMIDSRV------LENLKQQLEEQEY 1211
+ + H+V + K L L + D + +ENL+ ++ E
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
+LQ + + + +F + Q+ + + + L Q Q + L L+ ++I + +
Sbjct: 792 ELQ-QASAKLDVF---QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEA 847
Query: 1272 QHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
Q + + +Q D+ Q+ Q +E+ +K++ L +S + N + E
Sbjct: 848 QKKDVCTELDAHKIQVQDL-------MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 1332 LMERI--EEDNLTYQ---------HLLPE--SPEPSASHALSDYETSEKSFFSRDQKQDN 1378
++I E++N+ Q +L + S + + H L+ E E F ++++K +
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN--EEYETKFKNQEKKMEK 958
Query: 1379 ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQ-GSTSI 1437
+K M + + LL + + L+K LE + + KQ + E Q S I
Sbjct: 959 VKQKAKEMQETLKKKLLDQEAK----LKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 1438 FASGSELHSSLTSEIHFLRK-QNQALNAMLIKGSRDKQKENDKLRE----SLSRKTVSLE 1492
+ S L ++ +I L + + LN ++ + ++ ++L+E L K +
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVA 1074
Query: 1493 HLQRE---YASVKEENER----LQKEGSEKERHNQQLIQEVRCSGQEL-SRVQEEVKLRQ 1544
L+++ + KEE + L++EG +++ +L ++++ + S Q+E KL+
Sbjct: 1075 ELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA 1134
Query: 1545 QLLSQNDKLLQSLRVELKAYEKL-------DEEHRRLRDGDKYPMESDNSFDLFDSSQAV 1597
L L +SL+ E+L +E+ R++ + +D F SS
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Query: 1598 TPKSVSE----------------------TPPLSGNDTDSLSCDSGSSATSTPCVSRLVT 1635
+ KS+ + T L T+ L + SS+ + +SR+
Sbjct: 1195 SNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELI--NISSSKTNAILSRISH 1252
Query: 1636 GHHLWASKNGRHVLG--LIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPH 1693
H ++ + + EA L+Q+++ Q L +I Q+A + +L K
Sbjct: 1253 CQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL---NISFQQA----THQLEEKENQ 1305
Query: 1694 PAPLSKFVSSVSTAKLTLE-----------EAYRRLKLLWRVSLPEDGQCPLHCEQIGEM 1742
+ + S+ T K L+ E + L + L E++ E
Sbjct: 1306 IKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEK 1365
Query: 1743 KAEVTKLHKKLFEQEKKLQNTMKL 1766
K E++ L K+L + +LQN++ L
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISL 1389
Score = 58.9 bits (141), Expect = 4e-08
Identities = 104/511 (20%), Positives = 212/511 (41%), Gaps = 91/511 (17%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV---EVESLKRELQ-- 118
E +I +KK+ + +EE+ +Q G H+ + N +L+ EV L+ +L+
Sbjct: 1645 EQKIAAIKKQLLSQ------MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV 1698
Query: 119 ---EREQLLI-KASKAVESLAEAGGSEIQR-VKEDARKKVQQVEDLLTKRILLL-----E 168
+ E L++ +++K V + E ++ Q V++ +K+ ++ LT++ LL E
Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758
Query: 169 KDVTAAQ------------AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMAL-- 214
K+ T + +LE A A ++++ L+ +L E K + +A +
Sbjct: 1759 KEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK 1818
Query: 215 ---------------VLDEKDRLIEELKLSLKSKEALIQ----CLKEEKSQMACPDENVS 255
V D+ + ++E +L+ + E I+ CL +K E ++
Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878
Query: 256 SG--ELRGLCAA-----PREEKERETEAAQMEH----------QKERNSFEERIQALEED 298
S +L+ L P E E TE H + + N E ++ E +
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
Query: 299 LREKEREIATEKKNSLKRDKAIQGLTMALKSK--EKKVEELNSEIEKLSAAF-AKAREAL 355
++ +EI +K+ K Q LK + +++ E++ E E L + ++ +
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLM 1998
Query: 356 QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415
++ TQ Q ++ E + KE ++ A + + + +KKI ++ DL++
Sbjct: 1999 REFNTQLAQKEQELEMTI--KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTA 2056
Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ 475
+R E+ L+ E + +RDL+ ++E+L+ + ++ + EN N
Sbjct: 2057 KRYEEILDAREEEMT---AKVRDLQTQLEELQKKYQQKLEQEENP------------GND 2101
Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLEVIQQ 506
I L QK L+ K+ E +Q
Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132
Score = 49.7 bits (117), Expect = 3e-05
Identities = 118/611 (19%), Positives = 245/611 (40%), Gaps = 86/611 (14%)
Query: 1200 ENLKQQLEEQEYKLQKEQNLNM----QLFSEIHNLQNKFRDLSPPR----------YDSL 1245
E L++QL+E+ +L+K ++L+M +L +++ + +N L +
Sbjct: 317 EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHET 376
Query: 1246 VQSQARELSLQRQQIK----DGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG---F 1298
++ + E++ R +IK G + Q + AFEEL +A E
Sbjct: 377 LEMKEEEIAQLRSRIKQMTTQGE---ELREQKEKSERAAFEELEKALSTAQKTEEARRKL 433
Query: 1299 QEQLNQCAELLEKL---EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355
+ ++++ + +EK E++ L + V+ + + + EE Q L +
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKE 493
Query: 1356 SHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKT 1415
+T E+ F ++ EK+ SQ+ + + L + + +
Sbjct: 494 QELTKKLQTREREF---QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE 550
Query: 1416 NEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQK 1475
+E + L+++ + T I EL SSL + + Q++ L L +K K
Sbjct: 551 SENKLRDLQQEAETY---RTRIL----ELESSLEKSLQENKNQSKDLAVHL---EAEKNK 600
Query: 1476 ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKE--GSEKERHNQQLIQEVRCSGQEL 1533
N ++ + + LE L+ + ++ E ++ K+ +E E+ ++ QE +E
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQE-----KET 655
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVE--------------LKAYEKLDEEHRRLRD-GD 1578
+E+ + + N+K L+ L V+ LKA KL+EE L+D D
Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTD 715
Query: 1579 KYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHH 1638
K E + D + S+ + +S T+ D + + L+
Sbjct: 716 KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ------LELLLKERD 769
Query: 1639 LWASKNGRHVLGLIEDYEALLKQISQG--QRLLAEMDIQTQEAPSSTSQELGTKGPHPAP 1696
++ HV E+ EA +K+ S+G Q+ A++D+ Q S+T ++ A
Sbjct: 770 KHLKEHQAHV----ENLEADIKR-SEGELQQASAKLDV-FQSYQSATHEQTKAYEEQLAQ 823
Query: 1697 LSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQ 1756
L + + + T ++ L + + + Q C ++ K +V L ++L +Q
Sbjct: 824 LQQKLLDLETERILLTKQVAEV----------EAQKKDVCTELDAHKIQVQDLMQQLEKQ 873
Query: 1757 EKKLQNTMKLL 1767
+++ +K L
Sbjct: 874 NSEMEQKVKSL 884
>gi|50658075 phosphodiesterase 4D interacting protein isoform 3
[Homo sapiens]
Length = 310
Score = 127 bits (320), Expect = 8e-29
Identities = 70/148 (47%), Positives = 97/148 (65%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++DFE + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ+
Sbjct: 142 LRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQD 201
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E
Sbjct: 202 KKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 261
Query: 180 KAFAGTETEKALRLRLESKLSEMKKMHE 207
+ A E EK L L KL + K E
Sbjct: 262 RMAALVEAEKECNLELSEKLKGVTKNWE 289
Score = 32.0 bits (71), Expect = 5.6
Identities = 40/161 (24%), Positives = 70/161 (43%), Gaps = 22/161 (13%)
Query: 172 TAAQAELEKAFAGTETEK-ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSL 230
T A + EK + E +L+LR+ M++ +E D R IE LK+ +
Sbjct: 139 TQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRE-----DIYKRNIE-LKVEV 192
Query: 231 KSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEE 290
+S + +Q K+ + EN++S E R+ E Q E + E
Sbjct: 193 ESLKRELQDKKQHLDKTWADVENLNSQN--------EAELRRQFEERQQETEHVYELLEN 244
Query: 291 RIQALEEDLREKEREIA-------TEKKNSLKRDKAIQGLT 324
+IQ L+E+ R + E A EK+ +L+ + ++G+T
Sbjct: 245 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 285
Score = 31.2 bits (69), Expect = 9.6
Identities = 29/112 (25%), Positives = 61/112 (54%), Gaps = 15/112 (13%)
Query: 399 RSIKKITQELSDLQQERERLEKD---LEEAHREK---SKGDCTIR--DLRNEVEKLRNEV 450
++++ + L+DL++E L+ LEE ++K S+ D R +L+ EVE L+ E+
Sbjct: 140 QALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL 199
Query: 451 NEREKAMENRY---KSLLSESNKKLHNQ----EQVIKHLTESTNQKDVLLQK 495
++++ ++ + ++L S++ +L Q +Q +H+ E K LLQ+
Sbjct: 200 QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 251
>gi|50658077 phosphodiesterase 4D interacting protein isoform 4
[Homo sapiens]
Length = 173
Score = 120 bits (300), Expect = 2e-26
Identities = 67/147 (45%), Positives = 93/147 (63%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE 207
A E EK L L KL + K E
Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWE 152
Score = 32.7 bits (73), Expect = 3.3
Identities = 30/109 (27%), Positives = 60/109 (55%), Gaps = 15/109 (13%)
Query: 402 KKITQELSDLQQERERLEKD---LEEAHREK---SKGDCTIR--DLRNEVEKLRNEVNER 453
+ ++Q L+DL++E L+ LEE ++K S+ D R +L+ EVE L+ E+ ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 454 EKAMENRY---KSLLSESNKKLHNQ----EQVIKHLTESTNQKDVLLQK 495
++ ++ + ++L S++ +L Q +Q +H+ E K LLQ+
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
Score = 31.6 bits (70), Expect = 7.3
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 15/107 (14%)
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
ELK+ ++S + +Q K+ + EN++S E R+ E Q E +
Sbjct: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQN--------EAELRRQFEERQQETEHV 101
Query: 285 RNSFEERIQALEEDLREKEREIA-------TEKKNSLKRDKAIQGLT 324
E +IQ L+E+ R + E A EK+ +L+ + ++G+T
Sbjct: 102 YELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 148
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 116 bits (291), Expect = 2e-25
Identities = 167/777 (21%), Positives = 313/777 (40%), Gaps = 129/777 (16%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIE-LKVEVESLKRE 116
R ++D E +I LK N L EE M+Q +Y+++ + +K +VE LK E
Sbjct: 396 RGLRDLEEEIQMLKS---NGALSTEEREEEMKQM------EVYRSHSKFMKNKVEQLKEE 446
Query: 117 LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-------------R 163
L +E + K L +EI +VK++ +K ++ L TK
Sbjct: 447 LSSKEAQWEELKKKAAGLQ----AEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 502
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESK-------------LSEMKKMHEGDL 210
I +L++ +TA E A TE + ALRLRLE K ++E K G++
Sbjct: 503 IEVLKESLTAK--EQRAAILQTEVD-ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 211 A-MALVLDEKDRL-------IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSG----- 257
+ +LD K+R IE L+ L+ KE + LKE + N +
Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619
Query: 258 ----ELRGLCAAPREEKERETEAAQME---HQKERNSFEERIQALEEDLREKEREIATEK 310
E +E+++R+ Q E ++K+ +E++ L+ DL EKE + K
Sbjct: 620 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
Query: 311 KNS-------LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEF 363
+++ LK+D ++ L +AL+ K+++ ++ S+++K
Sbjct: 680 EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA------------------- 720
Query: 364 QGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLE 423
+E AL + + + R Q+L R I + E S Q E +RL + L+
Sbjct: 721 -----HEAALEARASPEMSDRIQHL---------EREITRYKDESSKAQAEVDRLLEILK 766
Query: 424 EAHREKSKGDCTIRDLRNEVEKLRNEV---NEREKAMENRYKSLLSESNKKLHNQEQVIK 480
E EK+ D I +L +V+ +V +E+ + + +L E+ ++ N +
Sbjct: 767 EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQ 826
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQ----QNCYLMAAEDLELRSEGLITEKCSSQQPPGS 536
L +S +KD +++ E E +Q + L E +E + E + +
Sbjct: 827 QLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV-K 885
Query: 537 KTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQ 596
+ + S + K SS + L + KE + + + + + ++ E K
Sbjct: 886 QELESMKAKLSSTQQSLAE---KETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
Query: 597 DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN---NRFQVEHFSQEEL 653
+L + +K +E+++ ++R ++ QT + +N + F+ H +Q
Sbjct: 943 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002
Query: 654 KKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTI 713
K +IQ + EL + LK I L+ L +L +
Sbjct: 1003 KPSPDQIIQPLLELDQNRSKLKLYIGHLTT-----------LCHDRDPLILRGLTPPASY 1051
Query: 714 KIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEE 770
+ +DD+ + ++ ++ +L KG N L+ + I H P LE+
Sbjct: 1052 NL-DDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQ 1107
Score = 67.8 bits (164), Expect = 9e-11
Identities = 189/923 (20%), Positives = 365/923 (39%), Gaps = 152/923 (16%)
Query: 40 GNGLLPNVSEETVSP-----TRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHG 94
G LP VS + P R + D + Q+ E+ +EN L+ + E ++ +
Sbjct: 126 GEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNS 185
Query: 95 PTEHIYKT--NIELKVEVESLKREL------QEREQLLIKASKAVESLAEAGGSEIQRVK 146
KT + ELK E K E +E+ +++ + ++ ++ +A E+ R++
Sbjct: 186 -----IKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-RIQ 239
Query: 147 EDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH 206
D + QQ T + E + ++ A E + L L EM+
Sbjct: 240 RDLNQLFQQDSSSRTGEPCVAE----LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI 295
Query: 207 EGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAA 265
E L+ +D I++L L+SK + +E+ + + + L L
Sbjct: 296 E---TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL-- 350
Query: 266 PREEKERETEAAQME-HQKERNS---------------FEERIQALEEDLREKEREI--- 306
E+KE+E + E H++ N+ + +I ++E LR+ E EI
Sbjct: 351 --EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 307 -------ATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQ 359
E++ +K+ + + + +K+K ++++ E+LS+ A+ E +KA
Sbjct: 409 KSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK------EELSSKEAQWEELKKKA- 461
Query: 360 TQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLE 419
+G +A ++ + K TE L+ ++ +T + SD +Q E L+
Sbjct: 462 --------------AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK 507
Query: 420 KDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQV- 478
+ L + + L+ EV+ LR + E+E + + K + + +K ++
Sbjct: 508 ESLTAKEQRAA-------ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
Query: 479 -IKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSK 537
+K + + +K +LQK E E ++ M++ ++S T + +
Sbjct: 561 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620
Query: 538 TIFSKEK-----KQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRK 592
+ KE+ K+ D +E + ++E D Y +K L+E S+ LQ +L++ A
Sbjct: 621 ALAEKERTIERLKEQRDRDE--REKQEEIDNYKKDLKDLKEKVSL--LQGDLSEKEASLL 676
Query: 593 QLEQDV--LSYQNLRKTLEEQISEI--RRREEESFSLYSDQTSYLSICLE----ENNRFQ 644
L++ L+ L+K + EI +++EE + S LE +
Sbjct: 677 DLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
Query: 645 VEHFSQE---------ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL 695
++H +E + + +V L++++KE+ + K I +L N L
Sbjct: 737 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL 796
Query: 696 ASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESK 755
EQ E S + + + ED+ + S Q LQ S LR + +
Sbjct: 797 KHKEQVEKKKSAQMLEEARRREDNLND--SSQQLQDS----------------LRKKDDR 838
Query: 756 ISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLE---SRPDLLKVVRELLLGQLFLTEQ 812
I + + A L E I E+ +L + +R + K V ELL+ + +Q
Sbjct: 839 IEELEEA-----LRESVQITA------EREMVLAQEESARTNAEKQVEELLMA-MEKVKQ 886
Query: 813 EVSGEHLDGKTEKTPKQKGEL-VHFVQTNSFSKPHDE--LKLSCEAQLVKAGEV-PKVGL 868
E+ E + K T + E H + + H E L++ EA L E + L
Sbjct: 887 EL--ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
Query: 869 KDASVQTVATEGDLLRFKHEATR 891
+ S T+ ++ K E R
Sbjct: 945 LELSSSKKKTQEEVAALKREKDR 967
Score = 47.4 bits (111), Expect = 1e-04
Identities = 85/369 (23%), Positives = 148/369 (40%), Gaps = 44/369 (11%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
LE+L +Q E++ L++E + + + + + K DS + S R L +
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPD--SAKTKALQTVIEMKDSKISSMERGLRDLEE 403
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
+I+ +S + +K E S E +E+L+ E+L+K
Sbjct: 404 EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK---- 459
Query: 1319 GKSVGV--EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376
K+ G+ E+ + + R + + L Q L ET F D KQ
Sbjct: 460 -KAAGLQAEIGQVKQELSRKDTELLALQTKL---------------ETLTNQF--SDSKQ 501
Query: 1377 DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS 1436
E K S+ +L E+ LR RLEE K KQ++ E +
Sbjct: 502 HIEVLKESLTAKEQRAAILQT---EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGE 558
Query: 1437 IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRE---SLSRKT----V 1489
I ++ +++ L+K+ + L L RDK+K+ L+E SL T
Sbjct: 559 IH-DLKDMLDVKERKVNVLQKKIENLQEQL----RDKEKQMSSLKERVKSLQADTTNTDT 613
Query: 1490 SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQ 1549
+L L+ A + ERL+++ ER Q+ I + ++L ++E+V L Q LS+
Sbjct: 614 ALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK---KDLKDLKEKVSLLQGDLSE 670
Query: 1550 NDKLLQSLR 1558
+ L L+
Sbjct: 671 KEASLLDLK 679
Score = 41.2 bits (95), Expect = 0.009
Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 45/397 (11%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
+ENL++QL ++E ++ + L ++ N L ++L + + L+ Q
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE----EALAEKERTIERLKEQ 635
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
+ +D R+ + ++L + + E+ +L E L +
Sbjct: 636 RDRD-------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 688
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD-QKQD 1377
G + T +E+ +E+ L + L ++ E + S + R+ +
Sbjct: 689 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 748
Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRK-------RLEESIK------TNEKLRKQLE 1424
+E+ K V D L+E ++E+ + LE +K N K ++Q+E
Sbjct: 749 DESSKAQAEV-----DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 803
Query: 1425 RQGS-----EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN-AMLIKGSRDKQKEND 1478
++ S E + ++ S +L SL + + + +AL ++ I R+ +
Sbjct: 804 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 863
Query: 1479 KLRESLSRKTV-----SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
+ + + K V ++E +++E S+K + Q+ +EKE H L E R +E+
Sbjct: 864 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+++E L +S+ D + L EL + +K +E
Sbjct: 924 LEMKQEALL--AAISEKDANIALL--ELSSSKKKTQE 956
Score = 38.9 bits (89), Expect = 0.046
Identities = 51/219 (23%), Positives = 94/219 (42%), Gaps = 35/219 (15%)
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
M ++ L I L+ +L+E ++ N+ LRK +E + S+ SI
Sbjct: 135 MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI----KTFW 190
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
S + LRK + + + R Q+EN ++ ++++ LQ E ++ N
Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-------MTIQALQDELRIQRDLN 243
Query: 1506 ERLQKEGSEK----------ERHNQQLIQEVRCSGQEL---SRVQEEVKLR----QQLLS 1548
+ Q++ S + E + Q+L E +EL + EE++LR +Q L+
Sbjct: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
Query: 1549 QNDK-------LLQSLRVELKAYEKLDEEHRRLRDGDKY 1580
D+ +LQS + KA E+ E RRL + + +
Sbjct: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH 342
Score = 38.9 bits (89), Expect = 0.046
Identities = 57/263 (21%), Positives = 112/263 (42%), Gaps = 26/263 (9%)
Query: 1326 MNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---ETEK 1382
M+ Q +L E + E++L + + E E S +++ S K+F+S + K++ + E
Sbjct: 152 MDLQTQLKEVLRENDLLRKDV--EVKESKLSSSMN----SIKTFWSPELKKERALRKDEA 205
Query: 1383 TSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGS 1442
+ + + ++ E Q ++ + L++ ++ L QL +Q S G +
Sbjct: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-QLFQQDSSSRTGEPCVAELTE 264
Query: 1443 EL-------HSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495
E H E+ LRK + + + + QK+ R+ +K + + +
Sbjct: 265 ENFQRLHAEHERQAKELFLLRKTLEEMELRI-----ETQKQTLNARDESIKKLLEMLQSK 319
Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLL--SQNDKL 1553
A EE+ + +E E H L + +E S ++EE+ R + S K
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379
Query: 1554 LQSLRVELKAYEKLDEEHRRLRD 1576
LQ++ +E+K K+ R LRD
Sbjct: 380 LQTV-IEMKD-SKISSMERGLRD 400
Score = 38.5 bits (88), Expect = 0.060
Identities = 77/448 (17%), Positives = 183/448 (40%), Gaps = 33/448 (7%)
Query: 1096 GTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKH-SQCSEAIITVLCGTEGAQ 1154
GT E + + + ++K++ L+ ++E Q + +K S E + ++ T
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDS--RVLENLKQQLEEQEYK 1212
L+ + +E T L + R + E ID+ + L++LK+++ +
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDERE-----KQEEIDNYKKDLKDLKEKVSLLQGD 667
Query: 1213 LQKEQNLNMQLFSEIHNLQNKF--RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
L +++ + L +L + +D + ++ + E Q+K H + +
Sbjct: 668 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 727
Query: 1271 RQ--HMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGV--- 1324
R M+ I+ E E+ + D + Q ++++ E+L+++E N K +
Sbjct: 728 RASPEMSDRIQHLEREITRYKDE----SSKAQAEVDRLLEILKEVENE-KNDKDKKIAEL 782
Query: 1325 --EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---- 1378
++ QN+ + ++ + + E + + ++S++ S +K D
Sbjct: 783 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842
Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437
E + SV + + + +L + K++EE + EK++++LE ++ S+
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497
+ L + L + + L+ +K L S S+K Q E
Sbjct: 903 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT-----QEE 957
Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQE 1525
A++K E +RL ++ ++ ++ +L+ +
Sbjct: 958 VAALKREKDRLVQQLKQQTQNRMKLMAD 985
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 116 bits (290), Expect = 2e-25
Identities = 195/896 (21%), Positives = 365/896 (40%), Gaps = 180/896 (20%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + TRAR+ K + EL+KEN LK +++ +E + E + + N+ L++
Sbjct: 364 EDQLEGTRARSDK-----LHELEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEM 417
Query: 109 -EVESLKRELQ---EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
+ +S+ L E EQ+ + S+ E+ ++ G E+ + K++ LTK +
Sbjct: 418 AQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLE----SKLSEMKKMHEGDLAMALVLDEKD 220
L V + + K + + L ++E + E + + ++ EK
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 221 RLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE----- 275
+L + ++ ++ E I+ L++E + ++ VSS R +A K+ E E
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 276 --------------------AAQMEHQKERNSFEERIQALEEDLR--EKEREI------- 306
++EH KE+ ER + LE +L EKE E+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEELENELHHLEKENELLQKKITN 650
Query: 307 ---------ATEKKNS-LKRDK--------AIQGLTMALKSKEKKVEELNSE-------I 341
A E++NS L+R+ + + LT L+S EK+ +L+ E +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 342 EKLSAAFAKAREA------LQKAQTQEFQGSEDYETALSGKEALSAA-----LRSQNLTK 390
E L A K + L+ + Q +G E + + E L + + +Q L K
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
+ EN + I+++ EL DL+ E + L+K+LEE + + L E + L E
Sbjct: 771 TLENSN--KKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQET 824
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE---KDLEVIQQN 507
++ EK K L + NK+L Q ++ E N K L+K N+ K++ + +++
Sbjct: 825 SQLEKD-----KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 508 CYLMAAEDLELRS----------------EGLITEKCSSQQPPGSKTIFSKE-KKQSSDY 550
C + + E + E L++EK +QQ + E +K +
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---KT 607
E L+ + D L++S ES +L+ + KI AL +LE+ Q LR KT
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQL---- 663
+++ +++R++E + S I E+N + + EL K LI++
Sbjct: 1000 VKKNYEALKQRQDEERMVQSSP----PISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 664 -------------VKELYTDNQHLKKTIFDL--SCMGFQGNG-----------FPDRLAS 697
+K+L T N +L+ I L + Q + +
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 698 TEQTELL----------ASKEDEDTIKIGEDDEINFLSDQ-----------HLQQSNEIM 736
++ T L+ +S E+E+ I E +++ L D H +Q++E
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 737 KDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792
+SK G ++ E + D + + ++G +L L E+ +LLE++
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1231
Score = 110 bits (274), Expect = 2e-23
Identities = 320/1466 (21%), Positives = 569/1466 (38%), Gaps = 268/1466 (18%)
Query: 40 GNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHI 99
G LP+ S SP + MK E++ L E + K +I R++QE TE +
Sbjct: 220 GLHFLPHASSSAQSPCGSPGMKRTESR-QHLSVELADAKAKI----RRLRQELEEKTEQL 274
Query: 100 YKTNIELKVEVESLKRELQEREQLLIKASKA------VESLAEAG------GSEIQRVKE 147
EL+ LKR QE LL A A +++L E SE+ R KE
Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE 334
Query: 148 ---DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK- 203
D +VE+L +LLE + LE GT LE + ++K
Sbjct: 335 RLHDIEFYKARVEELKEDNQVLLE-----TKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 204 KMHEGDLAMALVLDEKDRLIEE-LKLSLKSKEALIQCLK--EEKSQMACPDENVSSGELR 260
K+H+ ++ + + + L+EE + L + K+++ + L E Q++ E +S +
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-LSEAPQK 448
Query: 261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNS--LKRDK 318
L E +ME+Q + EE ++ + + EK+N K+ +
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 319 AIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ-------KAQTQEFQGSEDYET 371
++ + K + + L+ ++ K A K E L+ K QE + +
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSK 431
+L + +SA R +++ K EN L SIK+ + +LS ++ E+ +++K+LE K K
Sbjct: 569 SLRQRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELE---HYKEK 623
Query: 432 GDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--LSESNKKLHNQEQVIKHLTESTNQK 489
G+ E+L NE++ EK E K + L + +K+ EQ L +
Sbjct: 624 GE--------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 490 DVLLQKFNEK--DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
L F LE +++ + E+LELR + + KC+S + ++ + ++
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELR-RNVESLKCASMK-------MAQLQLEN 727
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT 607
+ E + LKK ++ L+A K L + + Q L+KT
Sbjct: 728 KELESEKEQLKKGLEL----------------LKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
LE +I++ E E L + + L LEE ++ E+L+K+ L Q +L
Sbjct: 772 LENSNKKIQQLESELQDLEMENQT-LQKNLEE---LKISSKRLEQLEKENKSLEQETSQL 827
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
D + L+K + +Q E+ + +E+ +KIG
Sbjct: 828 EKDKKQLEK----------------ENKRLRQQAEIKDTTLEENNVKIG----------- 860
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787
+L++ N K LSK G + C+ L L E L
Sbjct: 861 NLEKEN---KTLSKE-----------------IGIYKESCVR-------LKELEKENKEL 893
Query: 788 LLESRPDL--LKVVRELLLGQLFLTEQEVSG-EHLDGKTEKTPKQKGELVHFVQTNSFSK 844
+ + D+ L +RE L+ + T+Q + E L + EK K L+H Q+ S+
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 845 PHDELKLSCEAQLVKAGEV--PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTA 902
+ L+ E+ L K+ E+ K+ +A ++ LR + + ++ +E A
Sbjct: 954 -YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE------A 1006
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSR-----LPILIKPSRSLGNMYRLPAT 957
L E + + S P I+ + K R L+K L + R AT
Sbjct: 1007 LKQRQDEERM---------VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQPPVGA 1015
LQ++ L+ +LK+ +T N L +++ + + TL NA+ V
Sbjct: 1058 ------LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE--ICPPDDLASLPSCKENPEDVL 1073
+ +S ++S+ QQ S E ++E I +DL SL + L
Sbjct: 1112 STLNS--------QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE--------TEYLKQK--IHDLETEL 1123
+ S+ + +S GT +S N E + LKQK + DLE L
Sbjct: 1164 E----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1219
Query: 1124 EGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSL---HQVRYV 1180
+ Q + K+ + A LCG +D T+S L +V
Sbjct: 1220 KVEQEKMLLENKNHETVAAEYKKLCGE-------------NDRLNHTYSQLLKETEVLQT 1266
Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL---QKEQNLNMQLFSEIH-NLQNKFRD 1236
H + L ++ LE +L+EQ +L + N +L S++ NL+ + R
Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE 1296
L Q + L LQ + + E+ +++ D+ +
Sbjct: 1327 L---------LDQIQTLMLQNRTL--------------------LEQNMESKDLFHVEQR 1357
Query: 1297 GFQEQLNQCAELLEKLEKLFLN-------------GKSVGVEMNTQNELMERIEEDNLTY 1343
+ ++LN+ EKLE+ ++ G + ++M +L++ ++ N
Sbjct: 1358 QYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM---RKLIKSKKDINRER 1414
Query: 1344 QHLLPESPEPSASH----ALSDYETSEKSFFSRDQKQDNET--EKTSVMVNSFSQDLLME 1397
Q L +P S S L ++ + S + +D +T K S +N Q +++
Sbjct: 1415 QKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLA 1474
Query: 1398 HIQEIRTLRKRLEESIKTNEKLRKQL 1423
T + + I T K RK+L
Sbjct: 1475 GQWTGSTENLEVPDDISTG-KRRKEL 1499
Score = 68.6 bits (166), Expect = 5e-11
Identities = 123/582 (21%), Positives = 239/582 (41%), Gaps = 79/582 (13%)
Query: 1030 TSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS 1089
++ ++RD E+D+ ++++ +D + + KE D+ + L +Q
Sbjct: 304 SARMYRD-ELDALREKAVRVDKLE------SEVSRYKERLHDIEFYKARVEELKEDNQVL 356
Query: 1090 AKVSVMGTDQSESINTSN--------ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
+ M DQ E + E LK K+HD+E E + + I +L + + E
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 1142 AI------ITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID 1195
++ G E Q +S+ S+ + + H+V + ++L
Sbjct: 417 MAQKQSMDESLHLGWELEQ--ISRTSELSEAPQKSLG--HEVNELTSSRLLKLEMENQSL 472
Query: 1196 SRVLENLKQQLEEQE---YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARE 1252
++ +E L+ ++ E K+ K + N +L ++ L+N E
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN-------------------E 513
Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312
+ ++Q +++ + + + K E L + S+ + E E LNQ L +
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
Query: 1313 EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSR 1372
++ + +E + L E I+E + + E + L Y+ EK R
Sbjct: 574 SQISAEARVKDIEKENK-ILHESIKETSSKLSKI--EFEKRQIKKELEHYK--EKG--ER 626
Query: 1373 DQKQDNE---TEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSE 1429
++ +NE EK + ++ +L + ++I L + E + N KL+K L+
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKIT-CEKIEALEQENSELERENRKLKKTLDS---- 681
Query: 1430 FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN------AMLIKGSRDKQKENDKLRES 1483
+ T S + +S L E LR+ ++L A L +++ + E ++L++
Sbjct: 682 -FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 1484 LSRKTVSL---EHLQREYASVKEENERLQKEGSEKERHNQQL---IQEVRCSGQELSRVQ 1537
L S E L+ Y + EN+RLQK + QQL +Q++ Q L +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 1538 EEVKLRQQLLSQNDKLLQSLRVELKAYEK----LDEEHRRLR 1575
EE+K+ + L Q +K +SL E EK L++E++RLR
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Score = 66.2 bits (160), Expect = 3e-10
Identities = 260/1409 (18%), Positives = 533/1409 (37%), Gaps = 241/1409 (17%)
Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201
++++K ++ +QQ+ + +L++ K+ + Q GTE K L L L
Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQ--------GTEEVKKLLLLL------ 128
Query: 202 MKKMHEGDLAMALVLDEKDRLIEELK-LSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
L A+ +K+ IE ++ L +K A+ ++E ENV +
Sbjct: 129 --------LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQ----ENVFDLQWM 176
Query: 261 GLCAAPREEKERETEAAQMEHQK---ERNSFEERIQALEEDLREKEREIATEKKNS---- 313
+ +E+ E + + ++ ER+ E I L E+ R+ + ++
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEE-RDGLHFLPHASSSAQSPC 235
Query: 314 ----LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369
+KR ++ Q L++ L + K+ L E+E+ + ++ L++ + + + ++
Sbjct: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 370 ETALSGKEALSAALRSQNL----TKSTENHRLRRSIKKITQELSDLQQERERLEK----- 420
LS +A SA + L K+ +L + + + L D++ + R+E+
Sbjct: 296 MNLLS--DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 421 ----------------------DLEEAHREKSKGDCTIRDL-------RNEVEKLRNE-- 449
L E +E + + D+ R ++E+L E
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 450 ----------------------VNEREKAMENRYKSLLSESNK-------KLHNQEQVIK 480
++ + E KSL E N+ KL + Q +
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
E ++ K L++ ++N L ++ +E+ ++ EK S Q
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 541 SKEKKQ--------SSDYEELIQVLKKEQDIYTHLVKSLQE------------------- 573
KEK Q + E I++L++E + V SL++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 574 -SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632
+SI ++L+KI ++Q+++++ Y+ + EE +E+ E+E+ L T+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
C +K+ L Q EL +N+ LKKT+ + FQ
Sbjct: 652 KITC------------------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 693 DRLASTEQTELLASKEDEDTIKIGEDDEINF-LSDQHLQQSNEIMK---DLSKGGCKNGY 748
+ ++ E L + + +++K L ++ L+ E +K +L K K
Sbjct: 694 KENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 749 LRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLF 808
+ D + LE + L +E L +E++ L K + EL +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSN--KKIQQLESELQDLEMENQ-TLQKNLEELKISSKR 809
Query: 809 LTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVKAGEVPKVG 867
L + E + L+ +T + K K +L + N + E+K + E VK G + K
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 868 LKDASVQTVATEGDLLRFK--HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSL 925
K S + + +R K + +E + I+ R + + Q L
Sbjct: 867 -KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 926 PGITNREAK----KSRLPILIKPSRSLGNMYRLPATQEVVTQLQS------QILELQGEL 975
+T+ K K RL L + + Y+L ++ T +S +I L+ L
Sbjct: 926 EKLTHELEKIGLNKERL--LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 976 KEFKTCNKQLHQKLILAEAVMEG--RPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSV 1033
+E N+QL Q+L + E + ++ ++ + PP+ +D+ E++ +TT +
Sbjct: 984 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--EDNKWERESQETTREL 1041
Query: 1034 WRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA-TYLSSKSQPSAKV 1092
+ K+ + +R+ A+L + K+ + L L ++ +
Sbjct: 1042 LKVKDRLIEVERNN------------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHS--QCSEAIITVLCGT 1150
+V +Q+ ++ T N ++ + ++ QN +Q+ S +E++I
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 1151 EGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQE 1210
+ D L K + +S ++ KH + ++ R LE+ QL +Q+
Sbjct: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209
Query: 1211 YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
+L+ + + +++ E L+NK + Y L R Q +K+ V+
Sbjct: 1210 GQLEDLEKM-LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE---VLQ 1265
Query: 1271 RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330
H N + LL S ++ E + ++L E+ ++L + + + +
Sbjct: 1266 TDHKN-----LKSLLNNSKLEQTRLEA------EFSKLKEQYQQLDITSTKLNNQCELLS 1314
Query: 1331 ELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389
+L +EE+N +HLL + + L + K F +Q+Q
Sbjct: 1315 QLKGNLEEEN---RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ------------- 1358
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEK 1418
++ + E+R +++LEE I K
Sbjct: 1359 -----YIDKLNELRRQKEKLEEKIMDQYK 1382
Score = 63.9 bits (154), Expect = 1e-09
Identities = 248/1346 (18%), Positives = 520/1346 (38%), Gaps = 204/1346 (15%)
Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
+++ F ERIQ L+ D + E ++ + +Q + + S+E +IE
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--------DIE 187
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
L A + L + + + + G L A S + + S +
Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
++ EL+D + + RL ++LEE + + D + E+E++ E+ K ++
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIEL----KRLQQENM 296
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+LLS++ ++++ D L +K D + + Y D+E
Sbjct: 297 NLLSDARSARMYRDEL-----------DALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
+ K +Q +KT+ + + + + + L+KE +LQ +++++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---------NLQLKAKLHDMEM 396
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
E + RK++E+ L E+ + +++S D++ +L LE+ +R
Sbjct: 397 ERDMD---RKKIEE-----------LMEENMTLEMAQKQSM----DESLHLGWELEQISR 438
Query: 643 F-QVEHFSQEELKKKVSDLIQL-VKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
++ Q+ L +V++L + +L +NQ L KT+ +L G ++ E+
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760
SK+ ++I E++ + Q LQ + KDL K + L T + +
Sbjct: 499 ENQRLSKK----VEILENEIVQ--EKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENS 549
Query: 761 GAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820
+E +N +++ + E+R ++ ++L + T ++S
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS----- 604
Query: 821 GKTEKTPKQ-KGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATE 879
K E +Q K EL H+ K+ + E
Sbjct: 605 -KIEFEKRQIKKELEHY--------------------------------KEKGERAEELE 631
Query: 880 GDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLP 939
+L + E E ++K N ++ E AL RE +K
Sbjct: 632 NELHHLEKE--NELLQKKITNLKITCEKIE-----------ALEQENSELERENRK---- 674
Query: 940 ILIKPSRSLGNM-YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEG 998
L K S N+ ++L + ++ +QL + LEL+ ++ K + ++ Q L L +E
Sbjct: 675 -LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELES 732
Query: 999 RPTPDKT---LLNAQ----PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDS 1051
K LL A + +YQ E + ++ T +++ ++ +++S
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT--------LENSNKKIQQLES 784
Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY 1111
E+ DL + + L +S K S + ++ + E +
Sbjct: 785 EL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKR 840
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF 1171
L+Q+ +T LE I L+K ++ I + + L K + +E+
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-----ENKELV- 894
Query: 1172 SSLHQVRYVKHVKILGPLAPEMIDSRV-LENLKQQLEEQEYKLQK-EQNLNMQLFSEIHN 1229
R +K L L +++ ++ + + LE+ ++L+K N L E
Sbjct: 895 -----KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 1230 LQNKFRDLSPPRYDSLVQS---QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
++++ L +L +S + +++ ++++ RQ + T+ K +E L Q
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009
Query: 1287 ASDVDYCVAEG-------------FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM 1333
D + V QE + ++ ++L ++ N ++ E +
Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393
+++E N Q + + S L + T+ ++ ++ Q +++ S + + +
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127
Query: 1394 LLMEH----------IQEIRTLRKRLEESIKTNEKLRKQLERQGSEF---VQGSTSIFAS 1440
LL++ I+E L+ + IK +EKL ERQ SE+ + ++ ++
Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1187
Query: 1441 GSEL---HSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESLSRKTVSL---- 1491
L H L + L KQ L + ++K ++K +K E+++ + L
Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1247
Query: 1492 EHLQREYASVKEENERLQKEGSE-KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN 1550
+ L Y+ + +E E LQ + K N +++ R E S+++E+ QQL +
Sbjct: 1248 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-EFSKLKEQY---QQLDITS 1303
Query: 1551 DKLLQSLRVELKAYEKLDEEHRRLRD 1576
KL + + L+EE+R L D
Sbjct: 1304 TKLNNQCELLSQLKGNLEEENRHLLD 1329
Score = 63.9 bits (154), Expect = 1e-09
Identities = 123/624 (19%), Positives = 259/624 (41%), Gaps = 52/624 (8%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL-VQSQARELSLQR 1257
L + KQ+LE+ E +L++ Q NM L S+ + + +L R ++ V E+S +
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333
Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFL 1317
+++ D + + + + + LL+ + EG + + ++ EL ++ +L
Sbjct: 334 ERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 1318 NGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377
+ +E + + +E + E+N+T + +S + S + S S S ++
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
Query: 1378 -----NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-------KTNEKLRKQLER 1425
NE + ++ L + ++E+RT +E + K N++L K++E
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
+E VQ S+ + L L E L K + L + + ++EN+ L +++S
Sbjct: 510 LENEIVQEKQSL-QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 1486 ----RKTVSLE----HLQRE----YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
R +S E +++E + S+KE + +L K EK + ++L + + G+
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL-RDGDKYPMESDNSFDL-- 1590
++ E+ ++ K + +L++ + E L++E+ L R+ K D+ +L
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 1591 -FDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVL 1649
+S + + E L N +SL C S A +L + S+ +
Sbjct: 688 QLESLEKENSQLDEENLELRRN-VESLKCASMKMA-------QLQLENKELESEKEQLKK 739
Query: 1650 GLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKL 1709
GL E +A K+ + + +DI+ Q + L L + +
Sbjct: 740 GL-ELLKASFKKTERLEVSYQGLDIENQR----LQKTLENSNKKIQQLESELQDLEMENQ 794
Query: 1710 TLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQL 1769
TL++ LK +S Q + + + +++ K K+L ++ K+L+ ++
Sbjct: 795 TLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 1770 SKRQEKVIFDQLVVTHKILRKARG 1793
+ + V L +K L K G
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIG 874
Score = 60.8 bits (146), Expect = 1e-08
Identities = 111/553 (20%), Positives = 219/553 (39%), Gaps = 65/553 (11%)
Query: 1067 ENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126
EN + + T + S ++K+ M + E+ S + E L+ +I + L+
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKM---EKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 1127 QNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL 1186
QN L K E I L Q + + +N + T SSL Q +
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQIS----- 577
Query: 1187 GPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
A + EN L + ++E KL K + Q+ E+ + + K
Sbjct: 578 ---AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----------- 623
Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304
+A EL + ++ + + Q T +K E ++A +++ ++
Sbjct: 624 --GERAEELENELHHLEKENELL----QKKITNLKITCEKIEA----------LEQENSE 667
Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364
KL+K + K++ ++ + + +++E+NL + + S A E
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424
E K+ E K S + L Q + +RL+++++ + K +QLE
Sbjct: 728 KELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN---AMLIKGSRDKQKENDKLR 1481
+ + + ++ + EL S + + L K+N++L + L K + +KEN +LR
Sbjct: 784 SELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKE----------GSEKERHNQQLIQEVRCSGQ 1531
+ K +LE + ++++EN+ L KE E E+ N++L++ +
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLF 1591
L ++E++ + Q + L+ L EL EK+ RL ++ D+ + L
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHEL---EKIGLNKERLLHDEQ--STDDSRYKLL 957
Query: 1592 DSSQAVTPKSVSE 1604
+S T K E
Sbjct: 958 ESKLESTLKKSLE 970
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 115 bits (288), Expect = 4e-25
Identities = 196/896 (21%), Positives = 366/896 (40%), Gaps = 181/896 (20%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + TRAR+ K + EL+KEN LK +++ +E + E + + N+ L++
Sbjct: 364 EDQLEGTRARSDK-----LHELEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEM 417
Query: 109 -EVESLKRELQ---EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
+ +S+ L E EQ+ + S+ E+ ++ G E+ + K++ LTK +
Sbjct: 418 AQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLE----SKLSEMKKMHEGDLAMALVLDEKD 220
L V + + K + + L ++E + E + + ++ EK
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 221 RLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE----- 275
+L + ++ ++ E I+ L++E + ++ VSS R +A K+ E E
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 276 --------------------AAQMEHQKERNSFEERIQALEEDLR--EKEREI------- 306
++EH KE+ ER + LE +L EKE E+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEELENELHHLEKENELLQKKITN 650
Query: 307 ---------ATEKKNS-LKRDK--------AIQGLTMALKSKEKKVEELNSE-------I 341
A E++NS L+R+ + + LT L+S EK+ +L+ E +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 342 EKLSAAFAKAREA------LQKAQTQEFQGSEDYETALSGKEALSAA-----LRSQNLTK 390
E L A K + L+ + Q +G E + + E L + + +Q L K
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
+ EN + I+++ EL DL+ E + L+K+LEE + + L E + L E
Sbjct: 771 TLENSN--KKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQET 824
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE---KDLEVIQQN 507
++ EK K L + NK+L Q ++ E N K L+K N+ K++ + +++
Sbjct: 825 SQLEKD-----KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 508 CYLMAAEDLELRS----------------EGLITEKCSSQQPPGSKTIFSKE-KKQSSDY 550
C + + E + E L++EK +QQ + E +K +
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---KT 607
E L+ + D Y L++S ES +L+ + KI AL +LE+ Q LR KT
Sbjct: 940 ERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQL---- 663
+++ +++R++E + S I E+N + + EL K LI++
Sbjct: 999 VKKNYEALKQRQDEERMVQSSP----PISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054
Query: 664 -------------VKELYTDNQHLKKTIFDL--SCMGFQGNG-----------FPDRLAS 697
+K+L T N +L+ I L + Q + +
Sbjct: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1114
Query: 698 TEQTELL----------ASKEDEDTIKIGEDDEINFLSDQ-----------HLQQSNEIM 736
++ T L+ +S E+E+ I E +++ L D H +Q++E
Sbjct: 1115 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174
Query: 737 KDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792
+SK G ++ E + D + + ++G +L L E+ +LLE++
Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230
Score = 107 bits (267), Expect = 1e-22
Identities = 321/1466 (21%), Positives = 572/1466 (39%), Gaps = 241/1466 (16%)
Query: 40 GNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHI 99
G LP+ S SP + MK E++ L E + K +I R++QE TE +
Sbjct: 220 GLHFLPHASSSAQSPCGSPGMKRTESR-QHLSVELADAKAKI----RRLRQELEEKTEQL 274
Query: 100 YKTNIELKVEVESLKRELQEREQLLIKASKA------VESLAEAG------GSEIQRVKE 147
EL+ LKR QE LL A A +++L E SE+ R KE
Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE 334
Query: 148 ---DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK- 203
D +VE+L +LLE + LE GT LE + ++K
Sbjct: 335 RLHDIEFYKARVEELKEDNQVLLE-----TKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 204 KMHEGDLAMALVLDEKDRLIEE-LKLSLKSKEALIQCLK--EEKSQMACPDENVSSGELR 260
K+H+ ++ + + + L+EE + L + K+++ + L E Q++ E +S +
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-LSEAPQK 448
Query: 261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNS--LKRDK 318
L E +ME+Q + EE ++ + + EK+N K+ +
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 319 AIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ-------KAQTQEFQGSEDYET 371
++ + K + + L+ ++ K A K E L+ K QE + +
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSK 431
+L + +SA R +++ K EN L SIK+ + +LS ++ E+ +++K+LE K K
Sbjct: 569 SLRQRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELE---HYKEK 623
Query: 432 GDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--LSESNKKLHNQEQVIKHLTESTNQK 489
G+ E+L NE++ EK E K + L + +K+ EQ L +
Sbjct: 624 GE--------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 490 DVLLQKFNEK--DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
L F LE +++ + E+LELR + + KC+S + ++ + ++
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELR-RNVESLKCASMK-------MAQLQLEN 727
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT 607
+ E + LKK ++ L+A K L + + Q L+KT
Sbjct: 728 KELESEKEQLKKGLEL----------------LKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
LE +I++ E E L + + L LEE ++ E+L+K+ L Q +L
Sbjct: 772 LENSNKKIQQLESELQDLEMENQT-LQKNLEE---LKISSKRLEQLEKENKSLEQETSQL 827
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
D + L+K + +Q E+ + +E+ +KIG
Sbjct: 828 EKDKKQLEK----------------ENKRLRQQAEIKDTTLEENNVKIG----------- 860
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787
+L++ N K LSK G + C+ L L E L
Sbjct: 861 NLEKEN---KTLSKE-----------------IGIYKESCVR-------LKELEKENKEL 893
Query: 788 LLESRPDL--LKVVRELLLGQLFLTEQEVSG-EHLDGKTEKTPKQKGELVHFVQTNSFSK 844
+ + D+ L +RE L+ + T+Q + E L + EK K L+H Q S
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ--STDD 951
Query: 845 PHDELKLSCEAQLVKAGEV--PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTA 902
+ L+ E+ L K+ E+ K+ +A ++ LR + + ++ +E A
Sbjct: 952 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE------A 1005
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSR-----LPILIKPSRSLGNMYRLPAT 957
L E + + S P I+ + K R L+K L + R AT
Sbjct: 1006 LKQRQDEERM---------VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQPPVGA 1015
LQ++ L+ +LK+ +T N L +++ + + TL NA+ V
Sbjct: 1057 ------LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110
Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE--ICPPDDLASLPSCKENPEDVL 1073
+ +S ++S+ QQ S E ++E I +DL SL + L
Sbjct: 1111 STLNS--------QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1162
Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE--------TEYLKQK--IHDLETEL 1123
+ S+ + +S GT +S N E + LKQK + DLE L
Sbjct: 1163 E----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1218
Query: 1124 EGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSL---HQVRYV 1180
+ Q + K+ + A LCG +D T+S L +V
Sbjct: 1219 KVEQEKMLLENKNHETVAAEYKKLCGE-------------NDRLNHTYSQLLKETEVLQT 1265
Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL---QKEQNLNMQLFSEIH-NLQNKFRD 1236
H + L ++ LE +L+EQ +L + N +L S++ NL+ + R
Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTM--IKAFEELLQASDVDYCV 1294
L D + + +L Q ++ V RQ+++ + ++ +E L+ +D
Sbjct: 1326 L----LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
Query: 1295 AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPS 1354
+ + K+ KL + K + E L + + + L + + S
Sbjct: 1382 FYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDS 1441
Query: 1355 A---SHALSDYET--SEKSF--------FSRDQKQDNETEKT----SVMVNSFSQDLLME 1397
+ S++L D +T ++KS F R++ +D + K S+ +N Q +++
Sbjct: 1442 SSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLA 1501
Query: 1398 HIQEIRTLRKRLEESIKTNEKLRKQL 1423
T + + I T K RK+L
Sbjct: 1502 GQWTGSTENLEVPDDISTG-KRRKEL 1526
Score = 69.3 bits (168), Expect = 3e-11
Identities = 260/1409 (18%), Positives = 534/1409 (37%), Gaps = 242/1409 (17%)
Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201
++++K ++ +QQ+ + +L++ K+ + Q GTE K L L L
Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQ--------GTEEVKKLLLLL------ 128
Query: 202 MKKMHEGDLAMALVLDEKDRLIEELK-LSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
L A+ +K+ IE ++ L +K A+ ++E ENV +
Sbjct: 129 --------LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQ----ENVFDLQWM 176
Query: 261 GLCAAPREEKERETEAAQMEHQK---ERNSFEERIQALEEDLREKEREIATEKKNS---- 313
+ +E+ E + + ++ ER+ E I L E+ R+ + ++
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEE-RDGLHFLPHASSSAQSPC 235
Query: 314 ----LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369
+KR ++ Q L++ L + K+ L E+E+ + ++ L++ + + + ++
Sbjct: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 370 ETALSGKEALSAALRSQNL----TKSTENHRLRRSIKKITQELSDLQQERERLEK----- 420
LS +A SA + L K+ +L + + + L D++ + R+E+
Sbjct: 296 MNLLS--DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 421 ----------------------DLEEAHREKSKGDCTIRDL-------RNEVEKLRNE-- 449
L E +E + + D+ R ++E+L E
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 450 ----------------------VNEREKAMENRYKSLLSESNK-------KLHNQEQVIK 480
++ + E KSL E N+ KL + Q +
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
E ++ K L++ ++N L ++ +E+ ++ EK S Q
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 541 SKEKKQ--------SSDYEELIQVLKKEQDIYTHLVKSLQE------------------- 573
KEK Q + E I++L++E + V SL++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 574 -SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632
+SI ++L+KI ++Q+++++ Y+ + EE +E+ E+E+ L T+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
C +K+ L Q EL +N+ LKKT+ + FQ
Sbjct: 652 KITC------------------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 693 DRLASTEQTELLASKEDEDTIKIGEDDEINF-LSDQHLQQSNEIMK---DLSKGGCKNGY 748
+ ++ E L + + +++K L ++ L+ E +K +L K K
Sbjct: 694 KENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 749 LRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLF 808
+ D + LE + L +E L +E++ L K + EL +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSN--KKIQQLESELQDLEMENQ-TLQKNLEELKISSKR 809
Query: 809 LTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVKAGEVPKVG 867
L + E + L+ +T + K K +L + N + E+K + E VK G + K
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 868 LKDASVQTVATEGDLLRFK--HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSL 925
K S + + +R K + +E + I+ R + + Q L
Sbjct: 867 -KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 926 PGITNREAK----KSRLPILIKPSRSLGNMYRLPATQEVVTQLQS------QILELQGEL 975
+T+ K K R L+ +S + Y+L ++ T +S +I L+ L
Sbjct: 926 EKLTHELEKIGLNKER---LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
Query: 976 KEFKTCNKQLHQKLILAEAVMEG--RPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSV 1033
+E N+QL Q+L + E + ++ ++ + PP+ +D+ E++ +TT +
Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--EDNKWERESQETTREL 1040
Query: 1034 WRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA-TYLSSKSQPSAKV 1092
+ K+ + +R+ A+L + K+ + L L ++ +
Sbjct: 1041 LKVKDRLIEVERNN------------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHS--QCSEAIITVLCGT 1150
+V +Q+ ++ T N ++ + ++ QN +Q+ S +E++I
Sbjct: 1089 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148
Query: 1151 EGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQE 1210
+ D L K + +S ++ KH + ++ R LE+ QL +Q+
Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208
Query: 1211 YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
+L+ + + +++ E L+NK + Y L R Q +K+ V+
Sbjct: 1209 GQLEDLEKM-LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE---VLQ 1264
Query: 1271 RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330
H N + LL S ++ E + ++L E+ ++L + + + +
Sbjct: 1265 TDHKN-----LKSLLNNSKLEQTRLEA------EFSKLKEQYQQLDITSTKLNNQCELLS 1313
Query: 1331 ELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389
+L +EE+N +HLL + + L + K F +Q+Q
Sbjct: 1314 QLKGNLEEEN---RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ------------- 1357
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEK 1418
++ + E+R +++LEE I K
Sbjct: 1358 -----YIDKLNELRRQKEKLEEKIMDQYK 1381
Score = 68.6 bits (166), Expect = 5e-11
Identities = 123/582 (21%), Positives = 239/582 (41%), Gaps = 79/582 (13%)
Query: 1030 TSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS 1089
++ ++RD E+D+ ++++ +D + + KE D+ + L +Q
Sbjct: 304 SARMYRD-ELDALREKAVRVDKLE------SEVSRYKERLHDIEFYKARVEELKEDNQVL 356
Query: 1090 AKVSVMGTDQSESINTSN--------ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
+ M DQ E + E LK K+HD+E E + + I +L + + E
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 1142 AI------ITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID 1195
++ G E Q +S+ S+ + + H+V + ++L
Sbjct: 417 MAQKQSMDESLHLGWELEQ--ISRTSELSEAPQKSLG--HEVNELTSSRLLKLEMENQSL 472
Query: 1196 SRVLENLKQQLEEQE---YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARE 1252
++ +E L+ ++ E K+ K + N +L ++ L+N E
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN-------------------E 513
Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312
+ ++Q +++ + + + K E L + S+ + E E LNQ L +
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR 573
Query: 1313 EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSR 1372
++ + +E + L E I+E + + E + L Y+ EK R
Sbjct: 574 SQISAEARVKDIEKENK-ILHESIKETSSKLSKI--EFEKRQIKKELEHYK--EKG--ER 626
Query: 1373 DQKQDNE---TEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSE 1429
++ +NE EK + ++ +L + ++I L + E + N KL+K L+
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKIT-CEKIEALEQENSELERENRKLKKTLDS---- 681
Query: 1430 FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN------AMLIKGSRDKQKENDKLRES 1483
+ T S + +S L E LR+ ++L A L +++ + E ++L++
Sbjct: 682 -FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 1484 LSRKTVSL---EHLQREYASVKEENERLQKEGSEKERHNQQL---IQEVRCSGQELSRVQ 1537
L S E L+ Y + EN+RLQK + QQL +Q++ Q L +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 1538 EEVKLRQQLLSQNDKLLQSLRVELKAYEK----LDEEHRRLR 1575
EE+K+ + L Q +K +SL E EK L++E++RLR
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Score = 65.9 bits (159), Expect = 4e-10
Identities = 246/1345 (18%), Positives = 521/1345 (38%), Gaps = 203/1345 (15%)
Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
+++ F ERIQ L+ D + E ++ + +Q + + S+E +IE
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--------DIE 187
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
L A + L + + + + G L A S + + S +
Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
++ EL+D + + RL ++LEE + + D + E+E++ E+ K ++
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIEL----KRLQQENM 296
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+LLS++ ++++ D L +K D + + Y D+E
Sbjct: 297 NLLSDARSARMYRDEL-----------DALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
+ K +Q +KT+ + + + + + L+KE +LQ +++++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---------NLQLKAKLHDMEM 396
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
E + RK++E+ L E+ + +++S D++ +L LE+ +R
Sbjct: 397 ERDMD---RKKIEE-----------LMEENMTLEMAQKQSM----DESLHLGWELEQISR 438
Query: 643 F-QVEHFSQEELKKKVSDLIQL-VKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
++ Q+ L +V++L + +L +NQ L KT+ +L G ++ E+
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760
SK+ ++I E++ + Q LQ + KDL K + L T + +
Sbjct: 499 ENQRLSKK----VEILENEIVQ--EKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENS 549
Query: 761 GAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820
+E +N +++ + E+R ++ ++L + T ++S
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS----- 604
Query: 821 GKTEKTPKQ-KGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATE 879
K E +Q K EL H+ K+ + E
Sbjct: 605 -KIEFEKRQIKKELEHY--------------------------------KEKGERAEELE 631
Query: 880 GDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLP 939
+L + E E ++K N ++ E AL RE +K
Sbjct: 632 NELHHLEKE--NELLQKKITNLKITCEKIE-----------ALEQENSELERENRK---- 674
Query: 940 ILIKPSRSLGNM-YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEG 998
L K S N+ ++L + ++ +QL + LEL+ ++ K + ++ Q L L +E
Sbjct: 675 -LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELES 732
Query: 999 RPTPDKT---LLNAQ----PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDS 1051
K LL A + +YQ E + ++ T +++ ++ +++S
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT--------LENSNKKIQQLES 784
Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY 1111
E+ DL + + L +S K S + ++ + E +
Sbjct: 785 EL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKR 840
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF 1171
L+Q+ +T LE I L+K ++ I + + L K + +E+
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-----ENKELV- 894
Query: 1172 SSLHQVRYVKHVKILGPLAPEMIDSRV-LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNL 1230
R +K L L +++ ++ + + LE+ ++L+K +L + +
Sbjct: 895 -----KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 1231 QNKFRDLSPPRYDSLVQS---QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA 1287
++++ L +L +S + +++ ++++ RQ + T+ K +E L Q
Sbjct: 950 DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 1288 SDVDYCVAEG-------------FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELME 1334
D + V QE + ++ ++L ++ N ++ E ++
Sbjct: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL 1394
++E N Q + + S L + T+ ++ ++ Q +++ S + + + L
Sbjct: 1070 QLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 1395 LMEH----------IQEIRTLRKRLEESIKTNEKLRKQLERQGSEF---VQGSTSIFASG 1441
L++ I+E L+ + IK +EKL ERQ SE+ + ++ ++
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187
Query: 1442 SEL---HSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESLSRKTVSL----E 1492
L H L + L KQ L + ++K ++K +K E+++ + L +
Sbjct: 1188 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND 1247
Query: 1493 HLQREYASVKEENERLQKEGSE-KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQND 1551
L Y+ + +E E LQ + K N +++ R E S+++E+ QQL +
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-EFSKLKEQY---QQLDITST 1303
Query: 1552 KLLQSLRVELKAYEKLDEEHRRLRD 1576
KL + + L+EE+R L D
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLD 1328
Score = 63.9 bits (154), Expect = 1e-09
Identities = 123/624 (19%), Positives = 259/624 (41%), Gaps = 52/624 (8%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL-VQSQARELSLQR 1257
L + KQ+LE+ E +L++ Q NM L S+ + + +L R ++ V E+S +
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333
Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFL 1317
+++ D + + + + + LL+ + EG + + ++ EL ++ +L
Sbjct: 334 ERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 1318 NGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377
+ +E + + +E + E+N+T + +S + S + S S S ++
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
Query: 1378 -----NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-------KTNEKLRKQLER 1425
NE + ++ L + ++E+RT +E + K N++L K++E
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
+E VQ S+ + L L E L K + L + + ++EN+ L +++S
Sbjct: 510 LENEIVQEKQSL-QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 1486 ----RKTVSLE----HLQRE----YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
R +S E +++E + S+KE + +L K EK + ++L + + G+
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL-RDGDKYPMESDNSFDL-- 1590
++ E+ ++ K + +L++ + E L++E+ L R+ K D+ +L
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 1591 -FDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVL 1649
+S + + E L N +SL C S A +L + S+ +
Sbjct: 688 QLESLEKENSQLDEENLELRRN-VESLKCASMKMA-------QLQLENKELESEKEQLKK 739
Query: 1650 GLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKL 1709
GL E +A K+ + + +DI+ Q + L L + +
Sbjct: 740 GL-ELLKASFKKTERLEVSYQGLDIENQR----LQKTLENSNKKIQQLESELQDLEMENQ 794
Query: 1710 TLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQL 1769
TL++ LK +S Q + + + +++ K K+L ++ K+L+ ++
Sbjct: 795 TLQKNLEELK----ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 1770 SKRQEKVIFDQLVVTHKILRKARG 1793
+ + V L +K L K G
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIG 874
Score = 61.6 bits (148), Expect = 7e-09
Identities = 111/553 (20%), Positives = 220/553 (39%), Gaps = 66/553 (11%)
Query: 1067 ENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126
EN + + T + S ++K+ M + E+ S + E L+ +I + L+
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKM---EKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 1127 QNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL 1186
QN L K E I L Q + + +N + T SSL Q +
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQIS----- 577
Query: 1187 GPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
A + EN L + ++E KL K + Q+ E+ + + K
Sbjct: 578 ---AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----------- 623
Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304
+A EL + ++ + + Q T +K E ++A +++ ++
Sbjct: 624 --GERAEELENELHHLEKENELL----QKKITNLKITCEKIEA----------LEQENSE 667
Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364
KL+K + K++ ++ + + +++E+NL + + S A E
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424
E K+ E K S + L Q + +RL+++++ + K +QLE
Sbjct: 728 KELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN---AMLIKGSRDKQKENDKLR 1481
+ + + ++ + EL S + + L K+N++L + L K + +KEN +LR
Sbjct: 784 SELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKE----------GSEKERHNQQLIQEVRCSGQ 1531
+ K +LE + ++++EN+ L KE E E+ N++L++ +
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLF 1591
L ++E++ + Q + L+ L EL EK+ RL ++ +D+ + L
Sbjct: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHEL---EKIGLNKERLLHDEQ---STDDRYKLL 956
Query: 1592 DSSQAVTPKSVSE 1604
+S T K E
Sbjct: 957 ESKLESTLKKSLE 969
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 113 bits (283), Expect = 1e-24
Identities = 146/740 (19%), Positives = 303/740 (40%), Gaps = 124/740 (16%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQ---QEFHGPTEHI--YKTNIE--------LK 107
K +N+I ++K+E + L+ +++ +F +HI K ++ L+
Sbjct: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167
EV++L+ L+E+E +L K +K ++ +AE G++ + + ++ + D+ +++ +L
Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD-----LKDMLDVKERKVNVL 548
Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK 227
+K + Q +L + EK + S L E K + D D + L+
Sbjct: 549 QKKIENLQEQLR------DKEKQM-----SSLKERVKSLQADTT------NTDTALTTLE 591
Query: 228 LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS 287
+L KE I+ LKE++ R+E+E++ E ++K+
Sbjct: 592 EALAEKERTIERLKEQRD---------------------RDEREKQEEIDN--YKKDLKD 628
Query: 288 FEERIQALEEDLREKEREIATEKKNS-------LKRDKAIQGLTMALKSKEKKVEELNSE 340
+E++ L+ DL EKE + K+++ LK+D ++ L +AL+ K+++ ++ S+
Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
Query: 341 IEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRS 400
++K +E AL + + + R Q+L R
Sbjct: 689 LKKA------------------------HEAALEARASPEMSDRIQHL---------ERE 715
Query: 401 IKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV---NEREKAM 457
I + E S Q E +RL + L+E EK+ D I +L +V+ +V +E+
Sbjct: 716 ITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775
Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ----QNCYLMAA 513
+ + +L E+ ++ N + L +S +KD +++ E E +Q + L
Sbjct: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
Query: 514 EDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE 573
E +E + E + + + + S + K SS + L + KE + + +
Sbjct: 836 ESARTNAEKQVEELLMAMEKV-KQELESMKAKLSSTQQSLAE---KETHLTNLRAERRKH 891
Query: 574 SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
+ + ++ E K +L + +K +E+++ ++R ++ QT
Sbjct: 892 LEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNR 951
Query: 634 SICLEEN---NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690
+ +N + F+ H +Q K +IQ + EL + LK I L+
Sbjct: 952 MKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTT------- 1004
Query: 691 FPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLR 750
L +L + + +DD+ + ++ ++ +L KG N L+
Sbjct: 1005 ----LCHDRDPLILRGLTPPASYNL-DDDQAAWENELQKMTRGQLQDELEKGERDNAELQ 1059
Query: 751 HTESKISDCDGAHAPGCLEE 770
+ I H P LE+
Sbjct: 1060 EFANAILQQIADHCPDILEQ 1079
Score = 70.9 bits (172), Expect = 1e-11
Identities = 131/684 (19%), Positives = 292/684 (42%), Gaps = 101/684 (14%)
Query: 127 ASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTE 186
AS SL +A + I ++ K+V + DLL K + + E ++++ + K F E
Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQL-KEVLRENDLLRKDVEVKESKLSSSMNSI-KTFWSPE 193
Query: 187 T--EKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEK 244
E+ALR SK++ K+ + V+ E++ + +++++++ + ++ ++ +
Sbjct: 194 LKKERALRKDEASKITIWKEQYR-------VVQEEN---QHMQMTIQALQDELR-IQRDL 242
Query: 245 SQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER 304
+Q+ D + +GE C A E E + EH+++ + + L + L E E
Sbjct: 243 NQLFQQDSSSRTGEP---CVA--ELTEENFQRLHAEHERQA----KELFLLRKTLEEMEL 293
Query: 305 EIATEKKNSLKRDKAIQGLTMALKSK---EKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
I T+K+ RD++I+ L L+SK K EE + +L+ A + +
Sbjct: 294 RIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
Query: 362 EFQGS-------EDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
E + S +E A A + AL++ K ++ + R ++ + +E+ L+
Sbjct: 354 EKENSMLREEMHRRFENA--PDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN 411
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK---AMENRYKSLLSE-SNK 470
++ EE ++ + ++N++ +++ E++ ++ A++ + ++L ++ S+
Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS 471
Query: 471 KLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR---SEGLITEK 527
K H +V+K + Q+ +LQ + L LR E ++ +K
Sbjct: 472 KQH--IEVLKESLTAKEQRAAILQ----------------TEVDALRLRLEEKETMLNKK 513
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKI 587
Q + + + D ++++ V +++ ++ +++LQE + + + +++ +
Sbjct: 514 TKQIQDMAEEK--GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE--QLRDKEKQMSSL 569
Query: 588 FALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEH 647
K L+ D + TLEE ++E R E + R + E
Sbjct: 570 KERVKSLQADTTNTDTALTTLEEALAEKERTIERL----------------KEQRDRDER 613
Query: 648 FSQEEL---KKKVSDLIQLVKELYTDNQHLKKTIFDL----SCMGFQGNGFPDRLASTEQ 700
QEE+ KK + DL + V L D + ++ DL S + G RL +
Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL---KT 670
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760
E+ ++ E+ +K+ + L++++E + + ++H E +I+
Sbjct: 671 LEIALEQKKEECLKM----------ESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
Query: 761 GAHAPGCLEEGAFINLLAPLFNEK 784
+ E + +L + NEK
Sbjct: 721 DESSKAQAEVDRLLEILKEVENEK 744
Score = 45.8 bits (107), Expect = 4e-04
Identities = 101/475 (21%), Positives = 185/475 (38%), Gaps = 68/475 (14%)
Query: 1108 ETEYLKQKIHDLETELEGYQ--NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSD 1165
E ++++ I L+ EL + N +FQ S+ E + L
Sbjct: 221 ENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT----------------- 263
Query: 1166 GEEMTFSSLH--QVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQK------EQ 1217
E F LH R K + +L EM +E KQ L ++ ++K +
Sbjct: 264 --EENFQRLHAEHERQAKELFLLRKTLEEM--ELRIETQKQTLNARDESIKKLLEMLQSK 319
Query: 1218 NLNMQLFSEIHNLQNKFRD--LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
L+ + E H + + + +SL++ + +E S+ R+++ +
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR-----FENAPDS 374
Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER 1335
KA + +++ D E +L E+++ L NG E + + ME
Sbjct: 375 AKTKALQTVIEMKDSKISSME------RGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
Query: 1336 IEEDNLTYQHLLPE-----SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSF 1390
+ ++ + + S + + AL + + FS D KQ E K S+
Sbjct: 429 YRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFS-DSKQHIEVLKESLTAKEQ 487
Query: 1391 SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450
+L E+ LR RLEE K KQ++ E + I ++
Sbjct: 488 RAAILQT---EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH-DLKDMLDVKER 543
Query: 1451 EIHFLRKQNQALNAMLIKGSRDKQKENDKLRE---SLSRKT----VSLEHLQREYASVKE 1503
+++ L+K+ + L L RDK+K+ L+E SL T +L L+ A +
Sbjct: 544 KVNVLQKKIENLQEQL----RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER 599
Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558
ERL+++ ER Q+ I + ++L ++E+V L Q LS+ + L L+
Sbjct: 600 TIERLKEQRDRDEREKQEEIDNYK---KDLKDLKEKVSLLQGDLSEKEASLLDLK 651
Score = 41.2 bits (95), Expect = 0.009
Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 45/397 (11%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
+ENL++QL ++E ++ + L ++ N L ++L + + L+ Q
Sbjct: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE----EALAEKERTIERLKEQ 607
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
+ +D R+ + ++L + + E+ +L E L +
Sbjct: 608 RDRD-------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD-QKQD 1377
G + T +E+ +E+ L + L ++ E + S + R+ +
Sbjct: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRK-------RLEESIK------TNEKLRKQLE 1424
+E+ K V D L+E ++E+ + LE +K N K ++Q+E
Sbjct: 721 DESSKAQAEV-----DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775
Query: 1425 RQGS-----EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN-AMLIKGSRDKQKEND 1478
++ S E + ++ S +L SL + + + +AL ++ I R+ +
Sbjct: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
Query: 1479 KLRESLSRKTV-----SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
+ + + K V ++E +++E S+K + Q+ +EKE H L E R +E+
Sbjct: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+++E L +S+ D + L EL + +K +E
Sbjct: 896 LEMKQEALL--AAISEKDANIALL--ELSSSKKKTQE 928
Score = 38.9 bits (89), Expect = 0.046
Identities = 51/219 (23%), Positives = 94/219 (42%), Gaps = 35/219 (15%)
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
M ++ L I L+ +L+E ++ N+ LRK +E + S+ SI
Sbjct: 135 MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI----KTFW 190
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
S + LRK + + + R Q+EN ++ ++++ LQ E ++ N
Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-------MTIQALQDELRIQRDLN 243
Query: 1506 ERLQKEGSEK----------ERHNQQLIQEVRCSGQEL---SRVQEEVKLR----QQLLS 1548
+ Q++ S + E + Q+L E +EL + EE++LR +Q L+
Sbjct: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
Query: 1549 QNDK-------LLQSLRVELKAYEKLDEEHRRLRDGDKY 1580
D+ +LQS + KA E+ E RRL + + +
Sbjct: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH 342
Score = 38.9 bits (89), Expect = 0.046
Identities = 57/263 (21%), Positives = 112/263 (42%), Gaps = 26/263 (9%)
Query: 1326 MNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---ETEK 1382
M+ Q +L E + E++L + + E E S +++ S K+F+S + K++ + E
Sbjct: 152 MDLQTQLKEVLRENDLLRKDV--EVKESKLSSSMN----SIKTFWSPELKKERALRKDEA 205
Query: 1383 TSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGS 1442
+ + + ++ E Q ++ + L++ ++ L QL +Q S G +
Sbjct: 206 SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLN-QLFQQDSSSRTGEPCVAELTE 264
Query: 1443 EL-------HSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495
E H E+ LRK + + + + QK+ R+ +K + + +
Sbjct: 265 ENFQRLHAEHERQAKELFLLRKTLEEMELRI-----ETQKQTLNARDESIKKLLEMLQSK 319
Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLL--SQNDKL 1553
A EE+ + +E E H L + +E S ++EE+ R + S K
Sbjct: 320 GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA 379
Query: 1554 LQSLRVELKAYEKLDEEHRRLRD 1576
LQ++ +E+K K+ R LRD
Sbjct: 380 LQTV-IEMKD-SKISSMERGLRD 400
Score = 38.5 bits (88), Expect = 0.060
Identities = 77/448 (17%), Positives = 183/448 (40%), Gaps = 33/448 (7%)
Query: 1096 GTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKH-SQCSEAIITVLCGTEGAQ 1154
GT E + + + ++K++ L+ ++E Q + +K S E + ++ T
Sbjct: 525 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDS--RVLENLKQQLEEQEYK 1212
L+ + +E T L + R + E ID+ + L++LK+++ +
Sbjct: 585 TALTTLEEALAEKERTIERLKEQRDRDERE-----KQEEIDNYKKDLKDLKEKVSLLQGD 639
Query: 1213 LQKEQNLNMQLFSEIHNLQNKF--RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
L +++ + L +L + +D + ++ + E Q+K H + +
Sbjct: 640 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 699
Query: 1271 RQ--HMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGV--- 1324
R M+ I+ E E+ + D + Q ++++ E+L+++E N K +
Sbjct: 700 RASPEMSDRIQHLEREITRYKDE----SSKAQAEVDRLLEILKEVENE-KNDKDKKIAEL 754
Query: 1325 --EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---- 1378
++ QN+ + ++ + + E + + ++S++ S +K D
Sbjct: 755 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437
E + SV + + + +L + K++EE + EK++++LE ++ S+
Sbjct: 815 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 874
Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497
+ L + L + + L+ +K L S S+K Q E
Sbjct: 875 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT-----QEE 929
Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQE 1525
A++K E +RL ++ ++ ++ +L+ +
Sbjct: 930 VAALKREKDRLVQQLKQQTQNRMKLMAD 957
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 113 bits (283), Expect = 1e-24
Identities = 374/1895 (19%), Positives = 744/1895 (39%), Gaps = 339/1895 (17%)
Query: 65 NQITELKKENFNLKLRIYFLEERMQQEFHGPTEH-------IYKTNIELK---VEVESLK 114
+ +TEL+ + L++ + E + + ++ T H I+ +IE K V++E L+
Sbjct: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQ 816
Query: 115 RELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAA 174
EL + + + S + SL S++Q + + + ++V + +K
Sbjct: 817 NELDDVQLQFSEQSTLIRSLQ----SQLQNKESEVLEGAERVRHISSK------------ 860
Query: 175 QAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKE 234
EL +A + E E +++ L E K+ E + ++EKD+ + E+ S+ K
Sbjct: 861 VEELSQALSQKELEIT---KMDQLLLEKKRDVE---TLQQTIEEKDQQVTEISFSMTEK- 913
Query: 235 ALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
++Q L EEK + + + +L L A +KE+ E ++ ++N ++E A
Sbjct: 914 -MVQ-LNEEKFSLGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSSGLKQN-YDEMSPA 969
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKA--- 351
+ E + E KK + +R + +Q + K ++V L E+ L K
Sbjct: 970 GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPL 1029
Query: 352 --------------REALQKAQTQEFQGSEDY-ETALSGKEALSAALRSQNLTKSTENHR 396
+E +K T + Q E Y + +S KE +R K +
Sbjct: 1030 SETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQ 1089
Query: 397 LRRSIKKITQELSDLQQERERLEKDLEE----------AHREKSKGDCTIRDLRNEV--- 443
+ +K++ Q L D + + L+ ++ E ++ + S GD V
Sbjct: 1090 FQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISP 1149
Query: 444 ------EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK-------HLTESTNQK- 489
E + E+ E+ A+E + L + + L +++ ++K HL E Q+
Sbjct: 1150 PCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQK 1209
Query: 490 ---DVLLQKFNEKDLE-------VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539
+ L ++F+E+ E + Q + + D +L S E CSS PG +
Sbjct: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ-QESCSST--PGLEEP 1266
Query: 540 FSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL 599
K +Q L L + ++ +LQ S+ ++A+L +I A + +LE V
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 600 SYQNLRKTLEEQISEIRRR------EEESFSLYSDQTSYLSICLE---ENNRFQV---EH 647
S + E++ +++ + E ES S + + L+ E+++ Q+ EH
Sbjct: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH 1386
Query: 648 FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASK 707
EL+ K+ +L +L+ + D +L + + + + QTE++
Sbjct: 1387 L--RELQPKLDELQKLISKKEEDVSYLSGQLSE-----------KEAALTKIQTEII--- 1430
Query: 708 EDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGC 767
E ED IK ++ + ++ +E +K L C+ ++ +I + A
Sbjct: 1431 EQEDLIKA-----LHTQLEMQAKEHDERIKQLQVELCE---MKQKPEEIGEESRA----- 1477
Query: 768 LEEGAFINLLAPLFNEKATLL----LESRPDLLKVVRELLLGQLFLTEQEVSGEHLD--- 820
++ L A L + K L L+ L + E L L E +VS ++ +
Sbjct: 1478 -KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 821 --GKTEKTPKQKGELV-----HFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASV 873
G+ +++ +L+ ++ S S + LKL+ E GL +
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE------------GLTEDKE 1584
Query: 874 QTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREA 933
+ V E + L+ A W+EK + L E+ + L S ++N
Sbjct: 1585 KLVK-EIESLKSSKIAESTEWQEK--HKELQKEY-----------EILLQSYENVSNEAE 1630
Query: 934 KKSRLPILIKPSRSLGNMY-RLPATQEVVTQLQSQILELQGELKEFKT----CNKQLHQK 988
+ + ++ + +Y +L +T+ + + Q+ E + E++E K K QK
Sbjct: 1631 RIQHVVEAVRQEKQ--ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQK 1688
Query: 989 LILAEAV-----MEGRPTPD------KTLLNAQPPVGAAYQDSPGEQKGI-KTTSSVWRD 1036
++ E E P D +TLL++ + + E + + K S+ +
Sbjct: 1689 ILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE 1748
Query: 1037 KEMDSD--QQRSYEIDSEICPPDDLASLPS-------CKENPEDVLSPTSVATYLSSKSQ 1087
K+ S+ Q ++I+ + +L + +E + + T LS ++
Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTR 1808
Query: 1088 PSAKVSVMGTDQ-----SESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEA 1142
P+ SV S+ ++ +E Q+I L+ + G + + QK+ + S+
Sbjct: 1809 PTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE---EKQKNKEFSQT 1865
Query: 1143 IITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENL 1202
+ E ++ L + DGE V + +L E + SRV + L
Sbjct: 1866 L-------ENEKNTLLSQISTKDGELKMLQE-----EVTKMNLLNQQIQEEL-SRVTK-L 1911
Query: 1203 KQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRY-DSLVQSQARELSLQRQQIK 1261
K+ EE++ L E+ L QL ++ N +D++ + + L++S+ + L +++
Sbjct: 1912 KETAEEEKDDL--EERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELE 1969
Query: 1262 DGHGICVISRQHMNTMI-KAFEELLQ-----------ASDVDYCVAEGFQE--QLNQ-CA 1306
+ V + + + I K + E +Q A ++ + E QE QL + C
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 1307 ELLEKLEKLFLNGKSVG-VEMNTQNELMERIEEDNLTY--QHLLPESPEPSASHALSDYE 1363
EK+ L K++ V+ +Q +L I ++NL +H E ++ L D
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDL--EITKENLAQAVEHRKKAQAELASFKVLLDDT 2087
Query: 1364 TSEKSFFSRDQ---KQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLR 1420
SE + D K++ ++ K SV +D +E R L + E+ +K + ++
Sbjct: 2088 QSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE-----RRLEQAEEKHLKEKKNMQ 2142
Query: 1421 KQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKL 1480
++L+ E V +I E+ +L K KE +L
Sbjct: 2143 EKLDALRREKVHLEETI----GEIQVTLNK----------------------KDKEVQQL 2176
Query: 1481 RESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQ---------EVRCSG- 1530
+E+L L + +S++++ +R+ E + ER IQ E CS
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 1531 ----QELSRVQEEVKLRQQLLSQNDKLLQS-----LRVELKAYEKLDEEHRRLRDGDKYP 1581
+++S EE+K+ L + ++ +S ++++ K + L E++ L
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS----- 2291
Query: 1582 MESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWA 1641
+ + + L+ SSQ K SE L TD S + C
Sbjct: 2292 -QLEETRHLYHSSQNELAKLESELKSLKDQLTDL-------SNSLEKC------------ 2331
Query: 1642 SKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQ-TQEAPSSTSQELGTKGPHPAPLSKF 1700
+ ++ G+I EA ++ L E D+Q ++E S +E+ K K
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKE------QKI 2384
Query: 1701 VSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1760
+S +S + ++ A L+ + E Q E + + +KK ++ +L
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENL---LSQEEEENIVLEEENKKAVDKTNQL 2441
Query: 1761 QNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNL 1795
T+K ++ Q+K D V + L+ R +
Sbjct: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Score = 111 bits (278), Expect = 6e-24
Identities = 330/1661 (19%), Positives = 652/1661 (39%), Gaps = 251/1661 (15%)
Query: 84 LEERM--QQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAG-GS 140
LEE++ +++F + + +T + +++ L+ E+ E + ++ K + S +A G
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII---QKLITSNTDASDGD 1136
Query: 141 EIQRVKEDA------RKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGT--------E 186
+ VKE + + L ++IL LEK+ Q +L++A E
Sbjct: 1137 SVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE 1196
Query: 187 TEKALRL----------RLESKLSEMKKMHE--GDLAMALVLDEKDRLIEELKLSLKSK- 233
E+ LR RL+ + E K +E GD L + ++ + +L + + +
Sbjct: 1197 KERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQES 1256
Query: 234 --------EALIQCLKEEKSQMA-----CPD---ENVSSGELRG---LCAAPREEKERET 274
E L + ++ +Q CPD + + L+G + + KE E
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 275 EAAQMEHQKERNSFE-----ERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKS 329
E ++E + + E E + L+E + ++ EI + K S + + + L L+S
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
Query: 330 KEKKV------EELNSEIEKLSAAFAKAREALQ--KAQTQEFQGS-EDYETALSGKEALS 380
+ ++ EL ++++L +K E + Q E + + +T + +E L
Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436
Query: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTI---R 437
AL +Q L + H R IK++ EL +++Q+ E + ++ + + K + +
Sbjct: 1437 KALHTQ-LEMQAKEHDER--IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493
Query: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLS-ESNKKLHNQEQ--VIKHLTESTNQKDVLLQ 494
+ E + L+ E++ +E KSL ES N+E+ V+ L ++D L+
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI- 1552
Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
E D +++ + E L+L EGL +K + +++ S + +S++++E
Sbjct: 1553 --TEMDRSLLENQSLSSSCESLKLALEGLTEDK--EKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT------- 607
+ L+KE +I LQ ++++N + + +Q +Q++ Y LR T
Sbjct: 1609 KELQKEYEIL------LQSYENVSNEAERIQHVVEAVRQEKQEL--YGKLRSTEANKKET 1660
Query: 608 ---LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQ-------------- 650
L+E E+ +E+ + + EEN+R + E
Sbjct: 1661 EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720
Query: 651 --------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPD-RLASTEQT 701
E +K + L + + L ++ L + + DL +GN L +TE+
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ-IEGNVSKQANLEATEKH 1779
Query: 702 ELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNE-----------IMKDLSKGGCKNGYL 749
+ + +E T I GE +E + LS +E + KD S N YL
Sbjct: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYL 1839
Query: 750 RHTESKISDCDGAHAPGCLEEGAFIN--LLAPLFNEKATLL--LESRPDLLKVVRELLLG 805
+ + G LEE N L NEK TLL + ++ LK+++E +
Sbjct: 1840 QQIDQLKERIAG------LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893
Query: 806 QLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPK 865
L +Q K ++T +++ + + N ++ + + C+
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ----------- 1942
Query: 866 VGLKDASVQTVATEGDLLRFKHEATREAWEEKPI----NTALSAEHRPENLHGVPGWQAA 921
+ DA ++ E ++ K + E EEK T + +E R E L + G Q
Sbjct: 1943 -DVTDAQIKNELLESEMKNLK-KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000
Query: 922 LLSLPGITNREAKKSRLPILIKPSRSLGNMYR--------LPATQEVVTQLQSQILELQG 973
PG N+ K +L + + + + + + A + V L+ E Q
Sbjct: 2001 ----PG--NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
Query: 974 ELKEFKTCNKQL--HQKLILAEAVMEGRPTPDKTLLN-AQPPVGAAYQDSPGEQKGIKTT 1030
+L+ K Q H+K AE K LL+ Q D+ +K +++
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASF------KVLLDDTQSEAARVLADNLKLKKELQSN 2108
Query: 1031 SSVWRD--KEMDSDQQRSYE------IDSEICPPDDLASLPSCKENPEDVLSPTSVATYL 1082
+ K+ D D +R E + + + L +L K + E+ + V
Sbjct: 2109 KESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNK 2168
Query: 1083 SSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQ---C 1139
K + ++ T + T + + + ++ + + F +Q +
Sbjct: 2169 KDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 1140 SEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP--LAPEMIDSR 1197
E +VL +D L + + ++ S L + + K L ++ D+
Sbjct: 2229 KEDNCSVL------KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL 2282
Query: 1198 VLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSL 1255
EN L QLEE + QN +L SE+ +L+++ DLS +SL + + ++ +L
Sbjct: 2283 QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLS----NSLEKCKEQKGNL 2338
Query: 1256 Q---RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE--------GFQEQLN- 1303
+ RQQ D S + + T ++A EL + + E G +E +
Sbjct: 2339 EGIIRQQEADIQN-SKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397
Query: 1304 QCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYE 1363
AEL ++ +K E+ L+ + EE+N+ + ++ + + + +
Sbjct: 2398 AIAELRQQHDK----------EIKELENLLSQEEEENIVLEEENKKAVD-KTNQLMETLK 2446
Query: 1364 TSEKSFFSRDQKQDNETEKTSVMVNSFS------QDLLMEHIQEIRTLRKRLEESIKTNE 1417
T +K + + D+ + S + N Q L H+ I + ++E+ N
Sbjct: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506
Query: 1418 KLRKQ---LERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQ 1474
KL+++ L + + + A + L I Q + L + ++ +++ +
Sbjct: 2507 KLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE 2566
Query: 1475 KENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE-- 1532
+ KL E L + E L+R + +++EE + L KE + QL ++V +E
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Query: 1533 -------LSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEK 1566
L +EEV L S + K + L EL +K
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQK 2667
Score = 110 bits (275), Expect = 1e-23
Identities = 361/1858 (19%), Positives = 731/1858 (39%), Gaps = 309/1858 (16%)
Query: 106 LKVEVESLKRELQER-EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
L ++E +E ER +QL ++ + + E G E R K+ ++K+Q L++++
Sbjct: 1439 LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG--EESRAKQQIQRKLQAA--LISRKE 1494
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLA-MALVLDEKDRLI 223
L K+ + Q EL A E +ES++S K + L +AL+ +E+D+LI
Sbjct: 1495 AL--KENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552
Query: 224 EELKLSLKSKEAL----------IQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERE 273
E+ SL ++L ++ L E+K ++ E++ S ++ + KE +
Sbjct: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
Query: 274 TEAAQMEHQKERNSFE-ERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL- 327
E + E S E ERIQ + E +R++++E+ + + N + +K +Q +
Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672
Query: 328 ----------KSKEKKVEELNSEIEKLSAAF------------------AKAREALQKAQ 359
KSK++K+ EL E ++L A A +E L++ +
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732
Query: 360 TQEFQGSEDYETALSGKEALSAALRSQ------NLTK-----STENHRLRRSI-KKITQE 407
+ S+ +++ +S K++LS ++ N++K +TE H + ++ ++ TQ
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS 1792
Query: 408 LSDLQQERERLEKDL-----EEAHREKSKGDCTIRDLRN---------EVEKLRNEV--- 450
+ +E++ L E KS +D + ++++L+ +
Sbjct: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
Query: 451 -------NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK---- 499
E + +EN +LLS+ + K + +K L E + ++L Q+ E+
Sbjct: 1853 EEEKQKNKEFSQTLENEKNTLLSQISTK----DGELKMLQEEVTKMNLLNQQIQEELSRV 1908
Query: 500 ------------DLEVIQQNC----------YLMAAEDLELRSEGLITE-----KCSSQQ 532
DLE N Y D ++++E L +E KC S+
Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968
Query: 533 PPGSKTIFSKEKKQSSD----YEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF 588
+ + ++ K S+ Y E IQ +KE +H K LQE + Q E+
Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSH-AKELQEL--LKEKQQEV---- 2021
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
KQL++D + YQ LE + + + ES L+ +E + Q E
Sbjct: 2022 ---KQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELA 2078
Query: 649 S--------QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
S Q E + ++D ++L KEL ++ + +K S M + RL E+
Sbjct: 2079 SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK------SQMKQKDEDLERRLEQAEE 2132
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQS-NEIMKDLSKGGCKNGYLRHTESKISDC 759
L K ++ + +++ HL+++ EI L+K K+ ++ + +
Sbjct: 2133 KHLKEKKNMQEKLDALRREKV------HLEETIGEIQVTLNK---KDKEVQQLQENLDST 2183
Query: 760 DGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL 819
+ AF ++ L +++ ++ E++ E++ S
Sbjct: 2184 -------VTQLAAFTKSMSSLQDDRDRVIDEAKK----------------WERKFSDAIQ 2220
Query: 820 DGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSC-----EAQLVKAGEVPKVGLKDASVQ 874
+ E K+ V Q S +ELK++ + Q+ ++ +V L+
Sbjct: 2221 SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD 2280
Query: 875 TVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAK 934
T+ E L + E TR + N E ++L L ++N
Sbjct: 2281 TLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKD---------QLTDLSNS--- 2327
Query: 935 KSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILE-LQGELKEFKTCNKQLHQKLILAE 993
L K GN+ + QE Q E L+ +L+ + +LH+++ + E
Sbjct: 2328 ------LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE 2381
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
+ + + + Q + Q E K ++ S ++ + +++ +D
Sbjct: 2382 QKIISLLSGKEEAI--QVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439
Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113
+ L ++ KEN + K+Q + V M + Q++ + + L+
Sbjct: 2440 QLMETLKTIK--KEN-------------IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF-S 1172
++ L LE Q ++++ E I G D L+ D E + +
Sbjct: 2485 ER--HLSIILEKDQLIQEAAAENNKLKEEIR----GLRSHMDDLNSENAKLDAELIQYRE 2538
Query: 1173 SLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQN 1232
L+QV +K + L ++ ++ LEN +LEE KL++ + N L + LQ
Sbjct: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE---KLKESEEANEDLRRSFNALQE 2595
Query: 1233 KFRDLSPPRYDSL---VQSQARELSLQRQQIKDG--HGICVISRQHMNTMIKAF----EE 1283
+ +DLS +SL + R+++ +++ G H + + ++ + F +
Sbjct: 2596 EKQDLSK-EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKR 2654
Query: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEK-LEKLFLNGKSVGVEMNTQNELMERIEEDNLT 1342
+ + + CV + +++ + + L+K L+ L + + E T E + + D +
Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714
Query: 1343 Y-QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLL-MEHIQ 1400
Q LL + E A ++ +S S +D+ E+ + + L + ++
Sbjct: 2715 MEQKLLMVTKENKGLTA--QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Query: 1401 EIRTLRKRL---------------EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
E L + E S+ EKL +QL + + + S+ + S +++
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ 2832
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKT--VSLEHLQREYASVKE 1503
S + +++ N + + ++ E K R + T ++ L++ +S++
Sbjct: 2833 SFSKAMASLQNERDHLWNEL----EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQN 2888
Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE-----------EVKLRQQLLSQNDK 1552
+ +RL KE ++ Q+ QE+ +++QE + +LRQ+ LS +
Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHE 2948
Query: 1553 LLQSLRVELKAYEKLDEEHRRLRDGDKYPM---ESDNSFDLFDSSQAVTPKSVSETPPLS 1609
L Q LR+E ++E RR++ ++Y M + D + S S+T PL
Sbjct: 2949 LHQ-LRMEKSSWE---IHERRMK--EQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK 3002
Query: 1610 GNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGL------IEDYEALLKQIS 1663
S ++ +S + LV L ++ + + I+ + Q+
Sbjct: 3003 VQYQRQASPETSASPDGS---QNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLL 3059
Query: 1664 QGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLE---EAYRRLKL 1720
+ + L+ T ++ Q G H A L K V + L ++ A +
Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 1721 LWRVSLPEDGQCPLHC-----EQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQ 1773
+ R S PE+ + P +Q+ + EV +L K L E+ + L +++ Q
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQ 3177
Score = 94.4 bits (233), Expect = 9e-19
Identities = 366/1895 (19%), Positives = 711/1895 (37%), Gaps = 284/1895 (14%)
Query: 101 KTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL 160
K++ E ++E+E +K +LQE+E+L+ S L +A + + + + V + L
Sbjct: 137 KSSTEEEMEIEKIKHKLQEKEELI---STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ 193
Query: 161 TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH-----EGDLAMALV 215
K + +Q + E+A EK R + +L E + + + + M
Sbjct: 194 EKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQK 253
Query: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSS---------GELRGLCAAP 266
L R +EE + SL + ++ L++E + ++ +S LR
Sbjct: 254 LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 267 REEKERETEAAQMEHQKERNSF----EERIQALEEDLREKEREIATEKKNSL---KRDKA 319
REE + E ++E + + SF EE LE+ + + + E + S K
Sbjct: 314 REESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373
Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAKA-----REALQKAQT------QEFQGSED 368
++ T + S +K +EL S + L +K +A+Q AQT Q Q S++
Sbjct: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE 433
Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLR----RSIKKITQELSDLQQERERL---EKD 421
L+ SQ N + +I + + + +L+ E+ L +
Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 422 LEE--AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
LEE A EK T+ + +N + EV+E S++ +NK+ + E+
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSE---------ISIVDIANKRSSSAEESG 544
Query: 480 KHLTEST-----NQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPP 534
+ + E+T + VLL + E E+ L E E L ++ +
Sbjct: 545 QDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 535 G----SKTIFSKEKKQS----SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNK 586
G +F ++ Q + E + ++KEQ H ++ +E S+N+ EL
Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI-SLNDAGVELKS 663
Query: 587 IFALRKQLEQDVLS--------YQNLRKTLEEQISEIRRREEESFSLY-------SDQTS 631
KQ LS +Q+ + L+ QI E+ ++ +Y + + S
Sbjct: 664 ----TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEIS 719
Query: 632 YLSICLEE------NNRFQVEHFSQE--ELKKKVSDLIQLVKELYTDNQHLKKTIFDLS- 682
L+ +EE NN S+E +L +V +L +V EL + L+ + +
Sbjct: 720 NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL-SMVTELRAQVKQLEMNLAEAER 778
Query: 683 --CMGFQGNGFPDRLASTEQTELLASKEDEDTIKIG------EDDEINFLSDQHLQQSNE 734
+ ++ D L TEQ L+ + +KI +D ++ F L +S +
Sbjct: 779 QRRLDYESQTAHDNLL-TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ 837
Query: 735 IMKDLSKGGCKNG--YLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL---LL 789
+ G +RH SK+ + A + LE LL + TL +
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE 897
Query: 790 ESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDEL 849
E + ++ + + L E++ S G KT K++ L+ + + ++
Sbjct: 898 EKDQQVTEISFSMTEKMVQLNEEKFS----LGVEIKTLKEQLNLLSRAEEAKKEQVEEDN 953
Query: 850 KLSCEA-----QLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALS 904
++S ++ AG++ K L+ E DLL+ ++E + + IN
Sbjct: 954 EVSSGLKQNYDEMSPAGQISKEELQH--------EFDLLKKENEQRKRKLQAALIN---- 1001
Query: 905 AEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPIL---------IKPSRSLGNMYRLP 955
R E L V + L +L ++ K +P+ K ++
Sbjct: 1002 ---RKELLQRVSRLEEELANL-----KDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053
Query: 956 ATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGA 1015
QE+ L+ I E + EL+ + K L +KL E ++TL + +
Sbjct: 1054 KCQEIEIYLKQTISEKEVELQHIR---KDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110
Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSP 1075
+ Q I+ + D D D + I PP +S E E +L+
Sbjct: 1111 LQAEISENQAIIQKLITSNTDAS-DGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169
Query: 1076 TSVATYLSSKSQP--SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY----QNF 1129
L K Q +++ +++ Q + + E + K + L+ + + +N
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229
Query: 1130 IFQL-QKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188
QL Q Q E+I L T+ + S P G + + H + V +
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--GLEEPLFKATEQHHTQPVLESNLCPD 1287
Query: 1189 LAPEMIDSRVLE------NLKQQLEEQE--------------YKLQKEQNLNMQLFSEIH 1228
D+ L+ +K QL+E E +L K+ QL +I+
Sbjct: 1288 WPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347
Query: 1229 NLQNKFRDLSPPRYDSLVQSQARELSLQRQQI-----------------------KDGHG 1265
+ L +++ V +++ + L+ Q+ K
Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
Query: 1266 ICVISRQHMN---TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE----KLFLN 1318
+ +S Q + K E+++ D+ + + Q + E +++L+ ++
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPE--SPEPSASHALSDYETSEKSFFSRD--- 1373
+ +G E + ++ +++ ++ + L E S + S A E KS +
Sbjct: 1468 PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQV 1527
Query: 1374 --QKQDNET---------EKTSVMVNSFSQDLLMEH--IQEIRTLRKRLEESIKTNEKLR 1420
Q ++ +T E+ ++ + LL +L+ LE + EKL
Sbjct: 1528 SAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLV 1587
Query: 1421 KQLERQGSEFVQGSTSIFASGSEL----------HSSLTSE-------IHFLRKQNQALN 1463
K++E S + ST EL + ++++E + +R++ Q L
Sbjct: 1588 KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY 1647
Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVK--------EENERLQKE---- 1511
L + + +KE +K + ++ ++ R++A K EEN+RL+ E
Sbjct: 1648 GKL-RSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 1512 GSEKERHNQQLIQEVRCSGQELSRVQEEV----KLRQQLLSQNDKLLQSLRVELKAYEKL 1567
G + + L+ +EL RV+ E K Q L+S+ D L + ++ E
Sbjct: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGN 1766
Query: 1568 DEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATST 1627
+ L +K+ DN ++ + P E LS + + S S+ ++
Sbjct: 1767 VSKQANLEATEKH----DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
Query: 1628 PCVSRLVTGH-----HLWASKNGRHVLGLIEDYEALLKQISQ---GQRLLAEMDIQTQEA 1679
P VS+ + H +L + + +E+ + K+ SQ ++ I T++
Sbjct: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDG 1882
Query: 1680 PSSTSQELGTK-GPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPE-DGQCPLHCE 1737
QE TK + + +S V+ K T EE L+ L E +G +C+
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942
Query: 1738 QIGE-------MKAEVTKLHKKLFEQEKKLQNTMK 1765
+ + +++E+ L K + E E++ Q +K
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK 1977
Score = 92.0 bits (227), Expect = 5e-18
Identities = 336/1761 (19%), Positives = 669/1761 (37%), Gaps = 286/1761 (16%)
Query: 16 LSGCSGLVPSVPDDLDGINP-NAGLGNGLLPNVSEETVSPTRARNMKDFENQ-------I 67
LS SGL V +L G + + + L P + +E+ +D + + +
Sbjct: 2 LSRLSGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLV 61
Query: 68 TELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE----QL 123
ELK +++ +E +Q+E I K + K ++ SL + ++E + +
Sbjct: 62 VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV 121
Query: 124 LIKASKAVESLA--EAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKA 181
L ++ E L+ + +E + E + K+Q+ E+L++ L+ +T AQAE + A
Sbjct: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELIS----TLQAQLTQAQAE-QPA 176
Query: 182 FAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK 241
+ TE E+ + ++ + L EK+ I L+ L +A
Sbjct: 177 QSSTEMEEFVMMKQQ-------------------LQEKEEFISTLQAQLSQTQA------ 211
Query: 242 EEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLRE 301
E+ +Q +++ + + E E Q+ Q + + +++ LR
Sbjct: 212 EQAAQQVVREKD---------ARFETQVRLHEDELLQLVTQADVET------EMQQKLRV 256
Query: 302 KEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
+R++ +++ + R + + L L + E++ + L+ +++++ A R ++ + +
Sbjct: 257 LQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE 316
Query: 362 EFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKD 421
E E E L NL + E H L ++ Q ++L+ LE+
Sbjct: 317 SKILLEKMEL-----EVAERKLSFHNLQE--EMHHLLEQFEQAGQAQAELESRYSALEQK 369
Query: 422 LEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKH 481
+ EK+ ++ +K E+ A++++ LL + N++ Q I+
Sbjct: 370 HKAEMEEKTSHILSL-------QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 482 LTESTNQKDVLLQKF-NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
L + QK + +F N L+ + + ++ + E +S Q K +
Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ----KRVV 478
Query: 541 SKEKKQSSDYEELIQV--LKKEQDIYTHLVKSLQESDSINNLQAEL---------NKIFA 589
E ++ + I++ LK E + + + L+ + E+ NK +
Sbjct: 479 ELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538
Query: 590 LRKQLEQDVL--SYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEH 647
++ QDVL ++ K L + E++ +EE ++L + L+ + +H
Sbjct: 539 SAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE--------IAFLKLQLQGKRAEEADH 590
Query: 648 --FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP---DRLASTEQ-- 700
Q+E+K+ + I +K L+ T D M + + P ASTE
Sbjct: 591 EVLDQKEMKQMEGEGIAPIKM----KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS 646
Query: 701 ------------TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMK-DLSKGGCKNG 747
EL ++K+D D D D+ + ++I++ +L+ +
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 748 YLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKA-------TLLLESRPDLLKVVR 800
Y ++ + K + +N L F + A T L E R LL V+
Sbjct: 707 YEKNLDEKAKEISN------------LNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 801 ELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQT---NSFSKPHDELKLSCEAQL 857
EL + +TE + L+ + +Q+ L + QT N ++ L + +++
Sbjct: 755 ELSM----VTELRAQVKQLEMNLAEAERQR-RLDYESQTAHDNLLTEQIHSLSIEAKSKD 809
Query: 858 VKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPG 917
VK EV + L D +Q + + L+R ++ + E + + A H + +
Sbjct: 810 VKI-EVLQNELDDVQLQ-FSEQSTLIR-SLQSQLQNKESEVLEGAERVRHISSKVEELS- 865
Query: 918 WQAALLSLPGITNREAKKSRL-PILIKPSRSLGNMYR-LPATQEVVTQLQSQILELQGEL 975
++ +E + +++ +L++ R + + + + + VT++ + E +L
Sbjct: 866 --------QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 976 KEFKTC----NKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTS 1031
E K K L ++L L E + K + V + + + E S
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAK----KEQVEEDNEVSSGLKQNYDEMSPAGQIS 973
Query: 1032 SVWRDKEMD----SDQQRSYEIDSEICPPDDLASLPS-CKENPEDVLSPTSVATYLSSKS 1086
E D ++QR ++ + + +L S +E ++ + LS
Sbjct: 974 KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033
Query: 1087 QPSAKVSVMGTDQSESINTSNETE---YLKQKIHDLETEL--------------EGYQNF 1129
+ + + SE TS E YLKQ I + E EL E +Q
Sbjct: 1034 RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
Query: 1130 IFQLQKHSQCSEAIITVLCGTEG-----AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVK 1184
+ Q+ + Q I +L Q ++ + SDG+ V VK
Sbjct: 1094 VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGD--------SVALVKETV 1145
Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
++ P + E+ K +LEE+ L+KE+ LQ K ++ R
Sbjct: 1146 VISPPC-----TGSSEHWKPELEEKILALEKEK----------EQLQKKLQEALTSRKAI 1190
Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304
L ++Q +E L R+++K + N + + F+E + + E +QL Q
Sbjct: 1191 LKKAQEKERHL-REELKQ-------QKDDYNRLQEQFDEQSKEN-------ENIGDQLRQ 1235
Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEED--NLTYQH---------LLPESPEP 1353
L+ + ++GK + +EE T QH L P+ P
Sbjct: 1236 ----LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH 1291
Query: 1354 SASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI 1413
S + TS ++ ++ + E + + V+S + + L K+ EE
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSE-----------LTKKSEEVF 1340
Query: 1414 KTNEKLRKQ-LERQGSEFVQGSTSIFA-------SGSELHSSLTSEIHFLRKQNQALNAM 1465
+ E++ KQ LE + + V + A S+L + + L+ + L +
Sbjct: 1341 QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKL 1400
Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS----VKEENERLQKEGSEKERHNQQ 1521
+ K K+++ L LS K +L +Q E +K + +L+ + E + +Q
Sbjct: 1401 ISK----KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQ 1456
Query: 1522 LIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYP 1581
L E+ Q+ + EE + +QQ+ + L S + LK + L EE R +
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516
Query: 1582 MESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWA 1641
+S + S+Q +V L + D L + S +S L
Sbjct: 1517 TKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL-- 1574
Query: 1642 SKNGRHVLGLIEDYEALLKQI 1662
+ GL ED E L+K+I
Sbjct: 1575 -----ALEGLTEDKEKLVKEI 1590
Score = 78.2 bits (191), Expect = 7e-14
Identities = 138/682 (20%), Positives = 270/682 (39%), Gaps = 114/682 (16%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117
+ +K+ EN +++ ++EN L+ ++ Q + I K NI+ K +++S + +
Sbjct: 2408 KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME-TLKTIKKENIQQKAQLDSFVKSM 2466
Query: 118 --------------QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Q+ E+ + + L + +E ++KE+ R ++DL ++
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRL---------------RLESKLSEMKKMHEG 208
L + ++ + +L + ++++ L +LE KL E ++ +E
Sbjct: 2527 AKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE- 2584
Query: 209 DLAMAL--VLDEKDRL---IEELKLSLKSKEALIQCLKEE------KSQMACPDENV--- 254
DL + + +EK L IE LK+S+ + L+EE +Q+ +E V
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 255 ----SSGELR------GLCAAPRE--------EKERETEAAQMEH-----QKERNSFEER 291
SS + R L +E E + + E + H + E + EER
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704
Query: 292 IQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKA 351
+ L DL E E+++ K + IQ ++ S + + N E+++L + +
Sbjct: 2705 VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
Query: 352 REALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDL 411
+ L + + Q E AL + A S STE + L ++K+ Q+L
Sbjct: 2765 LKELAQLKEQGLLNRE--RDALLSETAFSM--------NSTEENSLSH-LEKLNQQLLSK 2813
Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKK 471
++ L LE+++ + + L+NE + L NE+ + K+ E + +S S
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2873
Query: 472 LHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL--------------- 516
Q + K ++ N +D LL++ + +Q N + L
Sbjct: 2874 AEVQ-SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQ 2932
Query: 517 ----ELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI--YTHLVKS 570
ELR E L + Q + E++ Y L+ + K+Q + +L++
Sbjct: 2933 IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY--LMAISDKDQQLSHLQNLIRE 2990
Query: 571 LQESDS-INNLQAELNKIFALRKQLEQD-----VLSYQNLRKTLEEQISEIRRREEESFS 624
L+ S S L+ + + + D V + LR L + + EI ++E
Sbjct: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ 3050
Query: 625 LYSDQTSYLSICLEENNRFQVE 646
L S+ S LEE N ++
Sbjct: 3051 LNSN----FSQLLEEKNTLSIQ 3068
Score = 72.8 bits (177), Expect = 3e-12
Identities = 133/669 (19%), Positives = 279/669 (41%), Gaps = 141/669 (21%)
Query: 64 ENQITELK-KENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQ 122
+ Q+ E++ ++N L+ + LEE+++ E E + ++ L+ E + L +E++ +
Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEKLK-ESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Query: 123 LLIKASKAVESLAEAGGSEIQ----RVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAEL 178
+ + ++ V +L E G + +VKE+ ++ + KRI LE+++ Q E
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 179 EKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLIEELKLSL-KSKEAL 236
K +E KL E+K +H M + + + EL L + ++ L
Sbjct: 2670 AKKVG----------EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719
Query: 237 IQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALE 296
+ KE K A + S G R+ E + + ++ S +E Q E
Sbjct: 2720 LMVTKENKGLTA---QIQSFGRSMSSLQNSRDHANEELDELKRKYDA---SLKELAQLKE 2773
Query: 297 EDLREKERE---------IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE---KL 344
+ L +ER+ + + ++NSL ++ L L SK++++ L+S++E
Sbjct: 2774 QGLLNRERDALLSETAFSMNSTEENSLSH---LEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRS-----QNLTKSTENHRLRR 399
+F+KA +LQ + + E + + GK+ +A + Q+L K+ + L+
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS--LQN 2888
Query: 400 SIKKITQELSDLQQERERLEKDLEEAH---------REKSKGDCTIRD--------LRNE 442
++ +EL +LQQ+ ++ +++ E H ++K+K +++ ++E
Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHE 2948
Query: 443 VEKLRNEVNE---REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499
+ +LR E + E+ M+ +Y +S+ +++L + + +I+ L S++Q L ++
Sbjct: 2949 LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR- 3007
Query: 500 DLEVIQQNCYLMAAEDLELRSEGLI--TEKCSSQQPPGSKTIFSKE---KKQSSDYEELI 554
Q + A+ D S+ L+ TE +Q K I KE ++ +S++ +L+
Sbjct: 3008 -----QASPETSASPD---GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLL 3059
Query: 555 --------------QVLKKEQDIYTHLV-------KSLQE-------------------- 573
Q L++ Q Y L+ K +QE
Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 574 --------------------SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQIS 613
+ N + E+N++ L ++ ++ +N EEQI
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
Query: 614 EIRRREEES 622
+ E +S
Sbjct: 3180 RLEHSEWDS 3188
Score = 55.8 bits (133), Expect = 4e-07
Identities = 115/508 (22%), Positives = 206/508 (40%), Gaps = 102/508 (20%)
Query: 48 SEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK 107
+EE V+ AR++ + E ++ + KEN L +I M +H + ELK
Sbjct: 2701 AEERVAEL-ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS-LQNSRDHANEELDELK 2758
Query: 108 VEVESLKREL----------QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVE 157
+ ++ +EL +ER+ LL + + ++ S E S ++++ + K +Q+
Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818
Query: 158 DLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLD 217
L ++ LE Q+ KA A + E R L ++L + +K EG A
Sbjct: 2819 HLSSQ----LEDSYNQVQS-FSKAMASLQNE---RDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 218 EKDRLIEELKLSLKS----KEALIQCLKEEKSQMACPDENVSSGELRGLCAAPRE--EKE 271
++ LK ++ S ++ L++ LK + Q ++ ++ EL L A +E +K
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT--ELHPLKAQLQEYQDKT 2928
Query: 272 RETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKE 331
+ + Q E ++E S++ + L + E K+ L MA+ K+
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL----------MAISDKD 2978
Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQ---EFQGSED------YETAL-------SG 375
+++ L + I +L ++ ++ + + Q Q E S D YET L S
Sbjct: 2979 QQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSL 3038
Query: 376 KEALSAALRSQNLT---------KSTENHRL---RRSIKKITQELSDLQQERERLEKDLE 423
KE LR Q L K+T + +L +S+++ Q DL LEK ++
Sbjct: 3039 KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQ 3098
Query: 424 E-------------AHREKS----KGD------------------CTIRDLRNEVEKLRN 448
E A +EK+ K D C R NE+ KL
Sbjct: 3099 ELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLE 3158
Query: 449 EVNEREKAMENRYKSLLSESNKKLHNQE 476
E ++ A EN S+ E ++L + E
Sbjct: 3159 EERDQRVAAENAL-SVAEEQIRRLEHSE 3185
Score = 47.0 bits (110), Expect = 2e-04
Identities = 147/781 (18%), Positives = 293/781 (37%), Gaps = 130/781 (16%)
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAII------------TVLCGTEGAQDGLSK 1159
L+QK L+ E + N I +L+ H++ + TVL +++ LSK
Sbjct: 75 LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSK 134
Query: 1160 PKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNL 1219
S EEM + K +++ L ++ ++ + + E +E+ + K+Q
Sbjct: 135 HDKSSTEEEMEIEKIKHKLQEKE-ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ 193
Query: 1220 NMQLFSEIHNLQNKFRDLSPPRY--------DSLVQSQARELSLQRQQIKDGHGICVISR 1271
+ F I LQ + + D+ ++Q R + Q+ + +
Sbjct: 194 EKEEF--ISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQ 251
Query: 1272 QHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAE----LLEKLEKLFLNGKSVGVEMN 1327
Q + + + EE ++ V + Q++L + L ++L+++ ++ +
Sbjct: 252 QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
Query: 1328 TQNE----LMERIE----EDNLTYQHLLPESPEPSASHALSDYETS-------EKSFFSR 1372
T+ E L+E++E E L++ +L E H L +E + E + +
Sbjct: 312 TEREESKILLEKMELEVAERKLSFHNLQEEM-----HHLLEQFEQAGQAQAELESRYSAL 366
Query: 1373 DQKQDNETE----------KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQ 1422
+QK E E KT + S L ++ + ++ ++ +S +T ++L Q
Sbjct: 367 EQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ 426
Query: 1423 LERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRE 1482
L+++ E Q + E +S TS + QA+ I + + E + +
Sbjct: 427 LQQKSKEISQFLNRLPLQQHET-ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKG 485
Query: 1483 SLSRKTVSLEHLQREYASVKEENERLQ----------------------KEGSEKERHNQ 1520
+L ++ LE L+ E + + L+ K S E Q
Sbjct: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
Query: 1521 QLIQEVRCSG-QELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGD- 1578
+++ +ELS + E+K Q+ ++ LQ R E +E LD++ + +G+
Sbjct: 546 DVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEG 605
Query: 1579 ---------------KYPM--ESDNSFDLFDSSQAVTPKSVSETPPLSGNDT----DSLS 1617
+P+ ++S + QA T + +S ND S
Sbjct: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
Query: 1618 CDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGL-------IEDYEALL----KQISQGQ 1666
D S ++ P + + H + +L L E YE L K+IS
Sbjct: 666 QDGDKSLSAVPDIGQC---HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN 722
Query: 1667 RLLAEMDIQTQE------APSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL 1720
+L+ E A S +L ++ + +++ + V ++ L EA R+ +L
Sbjct: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRL 782
Query: 1721 LWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQ 1780
+ D L EQI + E K+ + LQN + +QL ++ +
Sbjct: 783 DYESQTAHDN---LLTEQIHSLSIEAKSKDVKI----EVLQNELDDVQLQFSEQSTLIRS 835
Query: 1781 L 1781
L
Sbjct: 836 L 836
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 111 bits (277), Expect = 7e-24
Identities = 336/1579 (21%), Positives = 635/1579 (40%), Gaps = 252/1579 (15%)
Query: 101 KTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL 160
K + L+ V+SL+ L+ ++Q+ K E L + G EI+ A + Q
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG-EIEENLMKAEQMHQSFVAET 881
Query: 161 TKRILLLEKDVTAAQAELEKAFAGTET-EKALRL---RLESKLSEMKKMHEGDLAMALVL 216
++RI L++D +A Q + + + E EK L+L ++E++ +E++++ + + + L
Sbjct: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
Query: 217 DEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
E L E L L K ++I K E ++ EN G L+ + A+ +EK
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELT--QEN---GTLKEINASLNQEK------ 990
Query: 277 AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE 336
M ++ SF I E+ + E + EK L+R + L K K +E
Sbjct: 991 --MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE 1048
Query: 337 LNS------------------EIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEA 378
NS E+E+L AFAK Q+ T+ E + + E
Sbjct: 1049 KNSKLECLLNECTSLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELET 1105
Query: 379 LSAALRS-----QNLTKST------ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHR 427
+ ALRS QN +KS E L+ K+ +E++DL QE E+L K ++ H
Sbjct: 1106 VQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
Query: 428 EKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL-LSESNKKLHNQEQVIKHLTEST 486
++ IR+ E E RN+ N + + M+ K + L N +L E ++++
Sbjct: 1166 CQNLESEPIRNSVKERESERNQCNFKPQ-MDLEVKEISLDSYNAQLVQLEAMLRN----- 1219
Query: 487 NQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSK--TIFSKEK 544
K++ LQ+ +EK+ E +Q + DLE + + SQ+ G K I ++EK
Sbjct: 1220 --KELKLQE-SEKEKECLQHELQTIRG-DLETSN----LQDMQSQEISGLKDCEIDAEEK 1271
Query: 545 KQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQN- 603
S +E L Q+ HL SLQ ++N L EL KI + + + ++++ N
Sbjct: 1272 YISGPHE-----LSTSQNDNAHLQCSLQ--TTMNKLN-ELEKICEILQAEKYELVTELND 1323
Query: 604 --------LRKTLEE---QISEIRRREEESFSLY----------------SDQTSYLSIC 636
RK EE ++E++ ++S L+ ++Q
Sbjct: 1324 SRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAP 1383
Query: 637 LEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLA 696
L+E+N ++ S +E++ ++L +E + Q K + D C
Sbjct: 1384 LDESNSYEHLTLSDKEVQMHFAEL----QEKFLSLQSEHKILHDQHCQ-----------M 1428
Query: 697 STEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKI 756
S++ +EL + D++K E LS +++K++ G + G + S
Sbjct: 1429 SSKMSEL---QTYVDSLKA----ENLVLSTNLRNFQGDLVKEMQL-GLEEGLVPSLSS-- 1478
Query: 757 SDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSG 816
S + + L + +F L + + L S + + + ++F + +
Sbjct: 1479 SCVPDSSSLSSLGDSSFYR---ALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS--SLQE 1533
Query: 817 EHLDGKTEKTPKQKG--ELVHFVQTNSFSKPHDELKLSCEAQ-LVKAGEVPKVGLKDASV 873
E+L K + KG EL + + + ++L+ E+Q ++K E+ ++ + +
Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEV--YRQSLEKLEEKMESQGIMKNKEIQEL---EQLL 1588
Query: 874 QTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREA 933
+ E D LR ++ + E W++K + L E + Q LSL E
Sbjct: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESK----LAAEKKQTEQLSL----ELEV 1640
Query: 934 KKSRLPILIKPSRSLGNMYRLPATQ------EVVTQLQSQILELQGELKEFKTCNKQLHQ 987
+ +L L SRSL + A Q ++ + S+ E + + C+K Q
Sbjct: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQ 1700
Query: 988 KLIL-AEAVME-GRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQR 1045
L L E + E G P Q P + PGE K ++ + +
Sbjct: 1701 DLNLDIEKITETGAVKPTGECSGEQSP--DTNYEPPGEDKTQGSSECI---------SEL 1749
Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINT 1105
S+ + + P D L N ED+ ++ + S + ++ + D+ + +
Sbjct: 1750 SFSGPNALVPMDFLG-------NQEDI---HNLQLRVKETSNENLRLLHVIEDRDRKVES 1799
Query: 1106 -SNETEYLKQKIHDLETELEGYQNFIFQLQK--------HSQCSEAIITVLCG------- 1149
NE + L K+H E +L +L+K +S SE + C
Sbjct: 1800 LLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQR 1859
Query: 1150 ---TEGAQDGLSKPKNGSDGEEM-----TFSSLHQVRYVKHVKILGPLAPEM-------- 1193
+EG L + S E++ + + R++ L + E
Sbjct: 1860 VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 1194 ---IDSRVLENLKQQLEEQEYKLQK-----EQNLNMQLFSEIHNLQNKFRDLSPPRYDSL 1245
D V++ K LE+ QK E+ L++ + SE + L+ + +S + +
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV-VTSERNQLRGELDTMS--KKTTA 1976
Query: 1246 VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305
+ + ++ + Q+++ C+ Q +K ELLQ D E L
Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD------VSELLKDK 2030
Query: 1306 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS 1365
L EKL+ L + +++ + T+ EL +I + N + L+ ES A + SDYE
Sbjct: 2031 THLQEKLQSLEKDSQALSL---TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087
Query: 1366 EKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRLEESIKTNEKLRKQL 1423
S E V F+ L E + ++R ++L I+ +EK + +
Sbjct: 2088 NVS---------KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHI 2138
Query: 1424 ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRES 1483
+ E + + S+ L L + ++NQ L +I + + + E + L+
Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQ-----MSEENQEL---VILDAENSKAEVETLKTQ 2190
Query: 1484 LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLR 1543
+ SL+ + + +++ E E L K+ EK+ +L ++ S + L +E+ ++
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-DKLLSSFKSLLEEKEQAEI- 2248
Query: 1544 QQLLSQNDKLLQSLRVELK 1562
Q+ ++ ++ L+ +LK
Sbjct: 2249 -QIKEESKTAVEMLQNQLK 2266
Score = 88.2 bits (217), Expect = 7e-17
Identities = 162/743 (21%), Positives = 311/743 (41%), Gaps = 84/743 (11%)
Query: 57 ARNMKDFENQITELKKENFNLKLRIYFLEERMQ-----QEFHGPTEHIYKTNIE------ 105
A +K+ E + LK + NL+ + EE + E KT IE
Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198
Query: 106 ---------LKVEVESLKRELQEREQLLIKASKAVES----LAEAGGSEIQRVKEDARKK 152
L+ E E+L +++QE++ L + K + S L E +EIQ +KE+++
Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ-IKEESKTA 2257
Query: 153 VQQVEDLL---TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGD 209
V+ +++ L + + L D +A + E E LR +E + ++ +
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 210 LAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGE----------- 258
L + L E + + LK +++ E ++ + + A EN S GE
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-SKGEVETLKAKIEGM 2376
Query: 259 ---LRGL---CAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKN 312
LRGL R EKE T Q E Q+ + E + E L+EKE+E K+
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKE-QERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 313 SLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETA 372
S A++ L LK ++V L+++ E A ++ + ++ Q + + A
Sbjct: 2436 S---STAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 373 LSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK--DLEEAHREKS 430
+ L +++ +L + ++I++ + +Q + + + K +E H+
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 431 KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490
+ + +R+L E+E+ + + ++++ + +L S K L N+ ++ K S +K
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLE-VLQSSYKNLENELELTKMDKMSFVEK- 2610
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
+ K K+ E +Q+ + MA + EL+ E L EK + G + +E K S D
Sbjct: 2611 --VNKMTAKETE-LQREMHEMAQKTAELQEE-LSGEK---NRLAGELQLLLEEIKSSKDQ 2663
Query: 551 EELIQVLKKEQDIYTHLVKSLQ--ESDSINNLQAELNKIFALRKQLEQDVLSYQNL---- 604
+ + + E L KSL D + +I + +L + +Q L
Sbjct: 2664 LKELTLENSE------LKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 605 RKTLEEQISEIRRR---EEESFSLYSDQTSYLSICLEE-NNRFQVEHFSQEELKKKVSDL 660
K E +I R + +EE S + L EE NN + EELKK D
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
Query: 661 IQLVKELYTDNQHL--KKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGED 718
++ V +L +N+ K + SC + + E ++L A++E + T + D
Sbjct: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEE---KEILQKELSQLQAAQEKQKTGTV-MD 2833
Query: 719 DEINFLSDQHLQQSNEIMKDLSK 741
+++ L+ + +++ E +++ +K
Sbjct: 2834 TKVDELTTE-IKELKETLEEKTK 2855
Score = 85.1 bits (209), Expect = 6e-16
Identities = 294/1521 (19%), Positives = 587/1521 (38%), Gaps = 221/1521 (14%)
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
++A E ++ L R K+ E+ EG L D+ + ++ + L S EA +Q
Sbjct: 2 SWALEEWKEGLPTRALQKIQEL----EGQL------DKLKKEKQQRQFQLDSLEAALQKQ 51
Query: 241 KEEKSQMACPDENVS--SGELRGLCAAPREEKERETEAAQMEHQK------ERNSFEERI 292
K++ N+ + L +C + + K++ + Q++ + + NS +++I
Sbjct: 52 KQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI 111
Query: 293 QALEEDLREKEREIATEKKNSLKRDKAIQG-----------LTMALKSKEKKVEEL---- 337
+ LE++L+ + E+ ++ + D ++ LT + K E+L
Sbjct: 112 EKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY 171
Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ------NLTKS 391
N E+E+ A+ + K +Q + ++ +A S+ Q +L+ +
Sbjct: 172 NKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231
Query: 392 TENHRLRRSIKKI----TQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
++ +RR QE++ + + ++D + + S + L+ + ++LR
Sbjct: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
Query: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
N++NE E ++ K + + NK Q Q+ K E ++ VL + +E Q +
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIY--- 564
LE + + L TE S Q+ S E+K +E + L ++Q +
Sbjct: 352 QASTKYTALEQKLKKL-TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTL 410
Query: 565 --------THLVKSLQESDSINN-LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI--- 612
L + LQ++ +++N LQAEL+K+ ++++QLE ++ ++ E+
Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
Query: 613 ----SEIRRREEES------FSLYSDQTSY-----------LSICLEENNRFQVE----H 647
+E+RR EE +S+Q + + CL ++ F E +
Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530
Query: 648 FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCM-GFQGNGFPDRLASTEQTELLAS 706
SQE + + + + I + T + LK + DL + R EQ S
Sbjct: 531 TSQETMLRDLQEKINQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 707 KEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPG 766
K ++++ + E+ + L++ + K +E + H
Sbjct: 590 KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649
Query: 767 CLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKT 826
CL+ + + +NE+ L R +L +R L LD K+ +
Sbjct: 650 CLKTQ---QIKSHEYNERVRTLEMDRENLSVEIRNL-------------HNVLDSKSVEV 693
Query: 827 PKQKGELVHFVQTNSFS--KPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDL-- 882
QK + Q FS K E++ C G+V + K + + D
Sbjct: 694 ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCY 753
Query: 883 --LRFKHEATREAWEEKPINTALSAEHR---------PENLHG---VPGWQAALLSLPGI 928
L ++E+ R+ + K + + +H+ P H + G Q ++ S
Sbjct: 754 QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSE 813
Query: 929 TNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQ---ILELQGELKEFKTCNKQL 985
EA +S I +R + L + +++ + LQ Q +++++GE++E +Q+
Sbjct: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 986 HQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQR 1045
HQ + + +D+ Q + T S +KE + Q
Sbjct: 874 HQSFV----------------AETSQRISKLQEDTSAHQNVVAETLSALENKEKEL-QLL 916
Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTS-VATYLSSKSQPSAKVSVMGTDQSESIN 1104
+ ++++E ++ L ED L ++ LS + + + + + + E +
Sbjct: 917 NDKVETE---QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 973
Query: 1105 TSNET-----EYLKQKIHDLETELEGYQNFIFQLQKH-SQCSE------AIITVLCGTEG 1152
N T L Q+ +L + E + N+I + +K S+ S+ I+ C G
Sbjct: 974 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1033
Query: 1153 -AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR--VLENLKQQL--E 1207
A + LS+ + + L + ++R LE LK+ E
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNE------------CTSLCENRKNELEQLKEAFAKE 1081
Query: 1208 EQEY--KLQKEQNLNMQLFSEIHNLQNKFR-------DLSPPRYDSLVQSQARELSLQRQ 1258
QE+ KL + N L E+ +Q R + S L Q Q +
Sbjct: 1082 HQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
Query: 1259 QIKDGHGICVISRQHMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQC---AELLEKLEK 1314
K+ + + + Q M M E + L++ + V E E+ NQC ++ ++++
Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER-NQCNFKPQMDLEVKE 1200
Query: 1315 LFL---NGKSVGVEMNTQNE--LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF 1369
+ L N + V +E +N+ ++ E++ QH L + L D ++ E S
Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
Query: 1370 FSRDQKQDNETE--------KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
+D + D E + TS N+ Q L + ++ L K E +L
Sbjct: 1261 L-KDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
Query: 1422 QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK---GSRDKQKEND 1478
+L SE + + + +E L +E+ L + L+ L++ G ++ N+
Sbjct: 1320 ELNDSRSECITATRKM----AEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE 1375
Query: 1479 KLRESLS---------RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
+ SL+ T+S + +Q +A ++E+ LQ E K H+Q + S
Sbjct: 1376 QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE--HKILHDQHCQMSSKMS 1433
Query: 1530 GQELSRVQEEVKLRQQLLSQN 1550
EL + +K +LS N
Sbjct: 1434 --ELQTYVDSLKAENLVLSTN 1452
Score = 84.3 bits (207), Expect = 1e-15
Identities = 239/1205 (19%), Positives = 472/1205 (39%), Gaps = 191/1205 (15%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ- 118
++D + ++ L E L +++ E ++ + E + K ELK E L +L+
Sbjct: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIE-LEKIVGELKKENSDLSEKLEY 1848
Query: 119 ---EREQLL--IKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTA 173
+ ++LL ++ S+ + S E + R ED V +V D +R L +E +++
Sbjct: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSR--EDIGDNVAKVNDSWKERFLDVENELSR 1906
Query: 174 AQAE----------LEKAFAGTETEK-ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRL 222
++E LE +TEK L E+K + + E +++V E+++L
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE---ELSVVTSERNQL 1963
Query: 223 IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM--- 279
EL K AL Q L E+ + E+ S L + A E KE+ TE Q
Sbjct: 1964 RGELDTMSKKTTALDQ-LSEKMKEKTQELESHQSECLHCIQVAEAEVKEK-TELLQTLSS 2021
Query: 280 ---EHQKERNSFEERIQALEEDLR----------------EKEREIATEKKNSLKR---- 316
E K++ +E++Q+LE+D + KE+E+ ++ SL+
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 317 --------DKAIQG-------LTMALKSKEKKVEELNSEIEKL----SAAFAKAREALQK 357
KA++ + L S +++V +L IEKL A K +K
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 358 AQTQEFQGSEDYETALSGKEALSAALRSQNL-------------TKSTENHRLRRSIKKI 404
+ +E + + + + L + +Q L T T+ + RS+K
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGD---CTIRDLRNEVEKLRNEVNEREKA----M 457
+L L+ E+E L K ++E + S+ D + + L E E+ ++ E K +
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261
Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLE 517
+N+ K L+E+ L ++++K +S D +++ ++ + + L A E +
Sbjct: 2262 QNQLKE-LNEAVAALCGDQEIMKATEQSL---DPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 518 LRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQES-DS 576
L C QQ S+ K + + E +++ + Q+ H + S
Sbjct: 2318 L---------CVLQQLKESEHHADLLKGRVENLERELEIARTNQE---HAALEAENSKGE 2365
Query: 577 INNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC 636
+ L+A++ + + LE DV++ +R E +E+++ +E L +S+ +I
Sbjct: 2366 VETLKAKIEGMTQSLRGLELDVVT---IRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 637 LE-ENNRFQVEHFS---QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLS----CMGFQG 688
E E + Q++ S E L+ ++ +L + V L+ D + K +LS C+ +
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 689 NGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGY 748
L + ++ I+ ED + Q L++ +E + L KN
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK------QKLEKKDEEISRL-----KNQI 2531
Query: 749 LRHTE--SKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806
+ SK+S +G H + NL L E+ +L+S+ L+ E+L
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL--EQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 807 LFLTEQEVSGEHLDGKT--EKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVP 864
E E+ +D + EK K + +T + H+ + + E Q +GE
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAK-----ETELQREMHEMAQKTAELQEELSGEKN 2644
Query: 865 KV-GLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPE-NLHGVPGWQAAL 922
++ G ++ + + D L+ E T E E + +L H+ + G + A
Sbjct: 2645 RLAGELQLLLEEIKSSKDQLK---ELTLENSE---LKKSLDCMHKDQVEKEGKVREEIAE 2698
Query: 923 LSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCN 982
L EA+K +L+ ++ + +E +T + + + E+ K+
Sbjct: 2699 YQL---RLHEAEKKHQALLLDTNKQY--EVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 983 KQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSD 1042
++L+ L ++E + + +K + + ++ E
Sbjct: 2754 EELNNSLKATTQILE--------------------ELKKTKMDNLKYVNQLKKENERAQG 2793
Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSES 1102
+ + + SCK+ E+ + L + + +VM T E
Sbjct: 2794 KMK--------------LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839
Query: 1103 INTSNE-TEYLKQKIHDLETELEGYQNFIF---QLQKHSQCSEAIITVLCGTEGAQDGLS 1158
E E L++K + + L+ Y + + +L+K + E + LC + QD
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRG 2899
Query: 1159 KPKNG 1163
P G
Sbjct: 2900 SPLLG 2904
Score = 79.7 bits (195), Expect = 2e-14
Identities = 177/829 (21%), Positives = 357/829 (43%), Gaps = 178/829 (21%)
Query: 49 EETVSPTRAR--------NMKDFENQ-----ITELKKENFNLKLRIYFLEERMQQEFHGP 95
E+ V+P+R+ N F+N + +LK +N L+ +I LE R+Q
Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308
Query: 96 TEHIYKTNIELKVEVESLKRELQEREQLLIKA-SKAVESLAE---------AGGSEIQRV 145
+ K EL++++E K EL E+E++L K + V + A+ A +++++
Sbjct: 309 KGQVNKFQ-ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL 367
Query: 146 KEDARKKVQQVEDL---LTKRILLLEKDVTAAQAELEKAFAGTETEKA-LRLRLESKLSE 201
ED + Q E L ++I EK+ + +++F + E ++ RL +L +
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 202 MKKMH---EGDL-AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV--- 254
K MH + +L + V + + +EE K L E Q + +++++ E +
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 255 -------SSGELRGLCAAPREEKE-----RETEAAQMEHQKERNSFEERIQALEEDLREK 302
S + R +C E K +++ E + + S E ++ L+E + ++
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 303 EREIATEK---------------KNSLKR---------------DKAIQGLTMALKSKEK 332
E + EK ++ LK+ +K + L AL+ K+K
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
Query: 333 KVEEL----------NSEIEKLSAAFAKAREALQK--------AQTQEFQGSEDYE---T 371
+ EEL SE EKL +E LQ +TQ+ + E E T
Sbjct: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 667
Query: 372 ALSGKEALSAALRS-QNLTKSTENHRLRRSIKKITQELS--DLQQERE----RLEKDLEE 424
+E LS +R+ N+ S +S++ TQ+L+ +LQQ+ E + +K++E
Sbjct: 668 LEMDRENLSVEIRNLHNVLDS-------KSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRY------KSLLSESNKKLHNQEQV 478
+ S+ + DL ++++ L NE+ ++++ ++ + + LL + L E
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 479 IKHLTESTNQKDVLLQKF-----NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533
+ L + +Q+ + F + + + C L A D ++ ++ + S +
Sbjct: 781 QRSLL-AFDQQPAMHHSFANIIGEQGSMPSERSECRLEA--DQSPKNSAILQNRVDSLE- 836
Query: 534 PGSKTIFSKEKKQSSDY----EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA 589
+K+ +SD EEL+Q+ + +I +L+K+ Q S AE ++ +
Sbjct: 837 ----FSLESQKQMNSDLQKQCEELVQI---KGEIEENLMKAEQMHQS---FVAETSQRIS 886
Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD--QTSYLSIC-LEENNRFQVE 646
+L++D ++QN+ + E +S + +E+E L +D +T I L+++N +
Sbjct: 887 ---KLQEDTSAHQNV---VAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLED 939
Query: 647 HFSQEEL--------KKKVSDLIQL----VKELYTDNQHLKKTIFDLSCMGFQGNGFPDR 694
+ +L KK++S +I L ++EL +N LK+ L+ ++
Sbjct: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN---------QEK 990
Query: 695 LASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGG 743
+ +++E A+ DE + I+ LSDQ+ Q+ +++ + G
Sbjct: 991 MNLIQKSESFANYIDE------REKSISELSDQYKQEKLILLQRCEETG 1033
Score = 74.7 bits (182), Expect = 8e-13
Identities = 299/1456 (20%), Positives = 558/1456 (38%), Gaps = 214/1456 (14%)
Query: 234 EALIQCLKEE----KSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
E L+EE K + P + V EL LC R+ E+ E +ME Q + E
Sbjct: 1525 EVFCSSLQEENLTRKETPSAPAKGVE--ELESLCEVYRQSLEKLEE--KMESQGIMKNKE 1580
Query: 290 ERIQALEEDLREKEREIATEKKNSLKRDKAIQG-LTMALKSKEKKVEELNSEIEKLSAAF 348
IQ LE+ L + +E+ +K L ++ Q LT E K+ + E+LS
Sbjct: 1581 --IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL 1638
Query: 349 AKAREALQ--KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQ 406
AR LQ ++ G D E A+ G+ S + ++ +++TE R+ K
Sbjct: 1639 EVARLQLQGLDLSSRSLLGI-DTEDAIQGRNE-SCDISKEHTSETTE-----RTPKHDVH 1691
Query: 407 ELSDLQQERERLEKDLE---EAHREKSKGDCTIRDL---------RNEVEKLRNEVNERE 454
++ D +++ L D+E E K G+C+ ++ + ++E
Sbjct: 1692 QICDKDAQQD-LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELS 1750
Query: 455 KAMENRYKSLLSESNKK-LHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAA 513
+ N + N++ +HN + +K E++N+ LL ++D +V +
Sbjct: 1751 FSGPNALVPMDFLGNQEDIHNLQLRVK---ETSNENLRLLHVIEDRDRKVESLLNEMKEL 1807
Query: 514 ED-LELRSEGLIT--EKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKS 570
+ L L+ L+T E C + I + KK++SD E ++ + + L++
Sbjct: 1808 DSKLHLQEVQLMTKIEACIELEK-----IVGELKKENSDLSEKLEYFSCD---HQELLQR 1859
Query: 571 LQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT----LEEQISEIRRR----EEES 622
++ S+ +N+ E++ + R+ + +V + K +E ++S IR E E+
Sbjct: 1860 VETSEGLNS-DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
Query: 623 FSLYSD----QTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
L +D QT L + + N+ +V +EEL S+ QL EL D K T
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL--DTMSKKTTA 1976
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDE--DTIKIGEDD--EINFLSDQHLQQSNE 734
D + E+T+ L S + E I++ E + E L +E
Sbjct: 1977 LDQLSEKMK-----------EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE 2025
Query: 735 IMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPD 794
++KD + H + K+ + L + N +A L EK L+ ES
Sbjct: 2026 LLKDKT----------HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES--- 2072
Query: 795 LLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCE 854
E L Q L+E + ++ E +KGE ++ +S + +L+ E
Sbjct: 2073 ------ESL--QARLSESDYEKLNVSKALEAALVEKGEFA--LRLSSTQEEVHQLRRGIE 2122
Query: 855 AQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHG 914
V+ K L A + E ++ ++K N + EN
Sbjct: 2123 KLRVRIEADEKKQLHIAEKLK----------ERERENDSLKDKVENLERELQMSEENQE- 2171
Query: 915 VPGWQAALLSLPGITNREAKKSRLPILIKP-SRSLG----NMYRLPATQEVVT----QLQ 965
L + N +A+ L I+ +RSL ++ L + +E +T + Q
Sbjct: 2172 --------LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 966 SQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQK 1025
Q+ EL L FK+ ++ Q I + E T + L N + A G+Q+
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEI---QIKEESKTAVEMLQNQLKELNEAVAALCGDQE 2280
Query: 1026 GIKTTSSVWRDKEMDSDQQRSYEIDS-----EICPPDDLASLPSCKENPE--DVLSP--- 1075
+K T D ++ + Q I+ E L L KE+ D+L
Sbjct: 2281 IMKATEQSL-DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339
Query: 1076 ---------------TSVATYLSSKSQPSAKVSVMGTDQS-------------ESINTSN 1107
++ S + K + G QS E N +N
Sbjct: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399
Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQ--------KHSQCSEAIITVLCGTEGAQDGLSK 1159
E + +++I +LE ++N + + + K S E + T L L
Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
Query: 1160 PKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN----LKQQLEEQEYKLQK 1215
+ +E SS + ++ ++L L + VL++ L Q++E+ + KL+K
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
+ +L ++I + + LS + + + + L L+ ++ I V+ Q N
Sbjct: 2520 KDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE-QNLELRNLTVELEQKIQVL--QSKN 2576
Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAEL--LEKLEKLFLNGKSVGVEMNTQNELM 1333
++ E+LQ+S + L EL ++K+ + K E Q E+
Sbjct: 2577 ASLQDTLEVLQSS----------YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMH 2626
Query: 1334 ERIEEDNLTYQHLLPESPEPSAS-HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQ 1392
E ++ + L E + L + S K +++E +K+ ++
Sbjct: 2627 EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQV 2686
Query: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEI 1452
+ + +EI + RL E+ K ++ L +Q +Q S E SS EI
Sbjct: 2687 EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEI 2746
Query: 1453 HFLRKQNQALNAMLI----------KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVK 1502
L+ + LN L K D K ++L++ R ++ L + ++
Sbjct: 2747 DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLE 2806
Query: 1503 EENERLQKEGSE----KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558
EE E LQKE S+ +E+ + + + + + ++E + ++ + D+ L
Sbjct: 2807 EEKEILQKELSQLQAAQEKQKTGTVMDTKVD-ELTTEIKELKETLEEKTKEADEYLDKYC 2865
Query: 1559 VELKAYEKLDEEHRRL 1574
L ++EKL++ L
Sbjct: 2866 SLLISHEKLEKAKEML 2881
Score = 66.2 bits (160), Expect = 3e-10
Identities = 356/1851 (19%), Positives = 698/1851 (37%), Gaps = 336/1851 (18%)
Query: 64 ENQITELK----KENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
+N++ +LK KE+ ++ F EER Q +EL+ ++L+ E+ +
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLM-----------LELETVQQALRSEMTD 1116
Query: 120 REQLLIKASKAVESLAEAGG--SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAE 177
+ S +EAGG EI +KE+ K ++V DLL + L++ T + +
Sbjct: 1117 NQN---------NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1167
Query: 178 LEKAFAGTETEKALRLRLESKLSEMKKMH---EGDLAMALV-LDEKDRLIEELKLSLKSK 233
E+E +R ++ + SE + + + DL + + LD + + +L+ L++K
Sbjct: 1168 ------NLESEP-IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
Query: 234 EALIQ-------CLKEEKSQMACPDE-----NVSSGELRGL--CAAPREEK--------- 270
E +Q CL+ E + E ++ S E+ GL C EEK
Sbjct: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280
Query: 271 --ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328
+ + Q Q N E ++ + E L+ ++ E+ TE +S R + I A +
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNE-LEKICEILQAEKYELVTELNDS--RSECIT----ATR 1333
Query: 329 SKEKKVEELNSEIEKLSAAFAKAR-EALQKAQTQEF--QGSEDYETALSGKEALSAALRS 385
++V +L +E++ L+ E ++ EF Q +E + +L+
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAP---------- 1383
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
L +S L S K++ ++LQ++ L+ + + H + + + +L+ V+
Sbjct: 1384 --LDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS 1441
Query: 446 LRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ 505
L+ E + N L+ E L +E ++ L+ S L +
Sbjct: 1442 LKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSSSLSSLGDSSF---- 1495
Query: 506 QNCYLMAAEDLELRS--EGLITEK--------CSSQQPPG--SKTIFSKEKKQSSDYEEL 553
L D+ L S EG ++ CSS Q K S K + E L
Sbjct: 1496 YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESL 1555
Query: 554 IQVLKKEQDIYTHLVKSLQESDSINNLQA-ELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
+V ++ + L + ++ + N + EL ++ + +Q E D L Q L
Sbjct: 1556 CEVYRQSLE---KLEEKMESQGIMKNKEIQELEQLLSSERQ-ELDCLRKQYLS------- 1604
Query: 613 SEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQ 672
E E + Q S+ LE ++ E E+L L +
Sbjct: 1605 ------ENEQW-----QQKLTSVTLEMESKLAAEKKQTEQLS------------LELEVA 1641
Query: 673 HLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQS 732
L+ DLS G D + ++ ++ + +T + +++ + D+ QQ
Sbjct: 1642 RLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQ- 1700
Query: 733 NEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792
++ D+ K + G ++ T +C G +P E P +K E
Sbjct: 1701 -DLNLDIEKI-TETGAVKPT----GECSGEQSPDTNYE--------PPGEDKTQGSSECI 1746
Query: 793 PDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF---SKPHDEL 849
+L L+ FL QE +L + ++T + L+H ++ S ++
Sbjct: 1747 SELSFSGPNALVPMDFLGNQE-DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
Query: 850 KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRP 909
+L + L + + K+ +A ++ G+L + + + + S +H+
Sbjct: 1806 ELDSKLHLQEVQLMTKI---EACIELEKIVGELKKENSDLSEKL-------EYFSCDHQE 1855
Query: 910 ENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS--RSLGNMYRLPATQEVVTQLQSQ 967
L + E S L + S +G+ +V + +
Sbjct: 1856 --------------LLQRVETSEGLNSDLEMHADKSSREDIGDN-----VAKVNDSWKER 1896
Query: 968 ILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGI 1027
L+++ EL ++ + + + EA +E T +K L +D+ +QK I
Sbjct: 1897 FLDVENELSRIRSEKASIEHEALYLEADLEVVQT-EKLCLE---------KDNENKQKVI 1946
Query: 1028 KTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPS-CKENPEDVLSPTSVATYLS--S 1084
+ +Q R E+D+ L L KE +++ S S + +
Sbjct: 1947 VCLEEELSVVTSERNQLRG-ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005
Query: 1085 KSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY-------QNFIFQLQKHS 1137
+++ K ++ T S+ + +L++K+ LE + + +N I QL K
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
Query: 1138 QC----SEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS--------SLHQVRYVKHVKI 1185
+ SE++ L ++ + +SK + E+ F+ +HQ+R
Sbjct: 2066 ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 1186 LGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYD-- 1243
+ A E + E LK++ E + K +NL +L N + D + +
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVE 2185
Query: 1244 ---SLVQSQARELSLQR--------------QQIKDGHGICVISRQHMNTMIKAFEELL- 1285
+ ++ AR L + +QI++ G ++ ++ +F+ LL
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSFKSLLE 2241
Query: 1286 -------QASDVDYCVAEGFQEQLNQCAELLEKL----EKLFLNGKSVGVEMNTQNELME 1334
Q + E Q QL + E + L E + +S+ + +++L
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEK-SFFSRDQKQDNETEKTSVMVNSFSQD 1393
IE+ E+ E L + SE + + + ++ E E N
Sbjct: 2302 SIEKLRARL-----EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
Query: 1394 LLMEHIQ-EIRTLRKRLE---ESIKTNE----KLRKQLERQGSEFVQGSTSIFASGSELH 1445
L E+ + E+ TL+ ++E +S++ E +R + E +E + I SEL
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI----SELE 2412
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
+S + L+++ Q M K S + +L+E R V+ H +E KE+N
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER--VAALHNDQEACKAKEQN 2470
Query: 1506 ERLQKE-----------GSEKERHN--------QQLIQEVRCSGQELSRVQEEVKLRQQL 1546
Q E G ++ ++N LIQEV Q+L + EE+ +
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Query: 1547 LSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETP 1606
+ ++L+ L ++ E++ LR+ +E + + S A S+ +T
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRN---LTVELEQKIQVLQSKNA----SLQDTL 2583
Query: 1607 PLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQ 1666
+ + +L + L +K + + +E + + ++ Q
Sbjct: 2584 EVLQSSYKNLE-------------------NELELTKMDK--MSFVEKVNKMTAKETELQ 2622
Query: 1667 RLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSL 1726
R + EM +T E S G K L + + ++K L+E L L
Sbjct: 2623 REMHEMAQKTAELQEELS---GEKNRLAGELQLLLEEIKSSKDQLKEL-----TLENSEL 2674
Query: 1727 PEDGQCPLHCEQI---GEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774
+ C +H +Q+ G+++ E+ + +L E EKK Q LL +K+ E
Sbjct: 2675 KKSLDC-MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQ--ALLLDTNKQYE 2722
Score = 52.4 bits (124), Expect = 4e-06
Identities = 293/1575 (18%), Positives = 571/1575 (36%), Gaps = 259/1575 (16%)
Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
+ ++E E ++ KK +R + L AL+ +++KVE +E L
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL------------ 65
Query: 357 KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE 416
K + Q E E+ K+ +S L+ + + + +L K+I + L+QE +
Sbjct: 66 KRENQRLM--EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK----LEQELK 119
Query: 417 RLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQE 476
R + +LE + + D ++ + + + ++Y+ L + NK++ ++
Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 477 QV---IKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533
++ +K L + + N +D+ Q + + + + + S + + +
Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239
Query: 534 PGSKTIFSKEKKQSSDYEELIQVLKKEQDIY-------THLVKSLQ-ESDSINNLQAELN 585
S + FS E++ + L Q+ K++ + HL+ L+ ++ + N EL
Sbjct: 240 DFSASYFSGEQEVTPSRSTL-QIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
Query: 586 -KIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQ 644
++ K+++ V +Q L+ LE+ E+ +E+ L+ C +E R
Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEK-----------VLNKCRDELVRTT 347
Query: 645 VEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQG-----NGFPDRLASTE 699
++ ++ K + L Q +K+L D ++ C Q F + L S +
Sbjct: 348 AQY---DQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEEL-SRQ 403
Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
Q ++ +K E+ + H E+ K S L + K+
Sbjct: 404 QRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRA 463
Query: 760 DGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVR---ELLLGQLFLTEQEVSG 816
+ A ++E + + E L S +V EL + L + +
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523
Query: 817 EHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLS---------CEAQLVKAGEVPKVG 867
E + K +L + S ++LKL+ C L+K E
Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQ 583
Query: 868 LKDASVQTVATEGDLL---RFKHEATREAWEEKPINTALSAEHRP---------ENLHGV 915
L D +T LL K + E EEK + + +E+ ENL
Sbjct: 584 LNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
Query: 916 PGWQAALLSLPGITNREAKKSRLPILIKPSRSLG----NMYRLPATQEVVTQLQS-QILE 970
L I + E + R+ L +L N++ + ++ V + Q +E
Sbjct: 644 INHLETCLKTQQIKSHEYNE-RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYME 702
Query: 971 LQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTT 1030
LQ + EF + Q HQK I + + T G+ + ++
Sbjct: 703 LQ-QKAEF---SDQKHQKEIENMCLKTSQLT--------------------GQVEDLEHK 738
Query: 1031 SSVWRDKEMDSDQ-----QRSYEIDSEICPPDDLASLPSCKENPEDVLS----PTSVATY 1081
+ ++ MD D+ YE ++ D ASL + +++ +L+ P ++
Sbjct: 739 LQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD-ASLVTNEDHQRSLLAFDQQPAMHHSF 797
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
+ + + S + E+ + + L+ ++ LE LE + LQK QC E
Sbjct: 798 ANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQK--QCEE 855
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR---- 1197
+ + K + M +HQ + + + L + +
Sbjct: 856 LV---------------QIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 1198 ----VLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQAREL 1253
LEN +++L+ K++ EQ +L H L++ ++L Q + L
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKEL---------QLLSETL 951
Query: 1254 SLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE 1313
SL+++++ +IS + EEL Q + + LNQ E + ++
Sbjct: 952 SLEKKEMSS-----IISLNK-----REIEELTQENGT----LKEINASLNQ--EKMNLIQ 995
Query: 1314 KLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD 1373
K + + +EL ++ +++ L L E + ++
Sbjct: 996 KSESFANYIDEREKSISELSDQYKQEKLIL---------------LQRCEETGNAYEDLS 1040
Query: 1374 QKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG 1433
QK EK NS + LL E + LE+ L++ ++ EF+
Sbjct: 1041 QKYKAAQEK-----NSKLECLLNECTSLCENRKNELEQ-------LKEAFAKEHQEFL-- 1086
Query: 1434 STSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEH 1493
+ A E + +L E+ ++ QAL + + + + E L++ +
Sbjct: 1087 --TKLAFAEERNQNLMLELETVQ---QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
Query: 1494 LQREYASVKEENERLQK----------------EGSEKERHNQQ-----------LIQEV 1526
+Q+E + +ENE+L K S KER +++ ++E+
Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEI 1201
Query: 1527 RCSGQELSRVQEEVKLRQQ--LLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMES 1584
VQ E LR + L +++K + L+ EL+ + D E L+D M+S
Sbjct: 1202 SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI-RGDLETSNLQD-----MQS 1255
Query: 1585 DNSFDLFDSSQAVTPKSVSETPPL--SGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWAS 1642
L D K +S L S ND L C S T+ ++ L + +
Sbjct: 1256 QEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQC---SLQTTMNKLNELEKICEILQA 1312
Query: 1643 KNGRHVLGL----IEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQEL-----GTKGPH 1693
+ V L E A K + +LL E+ I ++ + + G G
Sbjct: 1313 EKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQ 1372
Query: 1694 PAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKL 1753
P VS A L +Y L L D + +H ++ E + HK L
Sbjct: 1373 P----NEQHPVSLAPLDESNSYEHLTL-------SDKEVQMHFAELQEKFLSLQSEHKIL 1421
Query: 1754 FEQEKKLQNTMKLLQ 1768
+Q ++ + M LQ
Sbjct: 1422 HDQHCQMSSKMSELQ 1436
Score = 47.4 bits (111), Expect = 1e-04
Identities = 72/359 (20%), Positives = 149/359 (41%), Gaps = 38/359 (10%)
Query: 1455 LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSE 1514
L + + L ++ ++ + + DKL++ ++ L+ L+ K++ E + EG+
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
+R NQ+L++ + ++ E+++++ ++ + L S + K EKL++E +R
Sbjct: 65 LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK---KQIEKLEQELKRC 121
Query: 1575 RDGDKYPMESDNSFDLFDSSQAVTPKSVSETP-----PLSGNDTDSLSCDSGSSATSTPC 1629
+ + ++ S D+ + TP+ + TP SG+ + L
Sbjct: 122 KSELERSQQAAQSADV-SLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
Query: 1630 VSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAP---SSTSQE 1686
+ V L A K + + ++ + I++ Q + Q ++ P SS SQ
Sbjct: 181 LEAEVKA--LQAKKASQTLPQATMNH----RDIARHQASSSVFSWQQEKTPSHLSSNSQR 234
Query: 1687 LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEV 1746
+ A V+ ++ TL+ R S ++ P + ++KA+
Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDA----NSSFFDNSSSP---HLLDQLKAQN 287
Query: 1747 TKLHKKLFEQEKKLQ----------NTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNL 1795
+L K+ E E +LQ N + LQL + KV +L+ K+L K R L
Sbjct: 288 QELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV---ELIEKEKVLNKCRDEL 343
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 858 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 911
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1150
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1208 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1372
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1373 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1421 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKL 1563
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1064
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1237
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1238 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1284
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1340
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1460 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1495 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 616 RRREEE 621
+ + EE
Sbjct: 1545 KTQLEE 1550
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 904 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 942
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 943 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 998 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1086
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1138
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1139 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1419
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1420 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1583
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDER 1609
Score = 79.3 bits (194), Expect = 3e-14
Identities = 124/635 (19%), Positives = 255/635 (40%), Gaps = 129/635 (20%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1376 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1430
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 285 RNSFEERIQA------------------------------------LEEDLREKEREIAT 308
E+ +QA L+ L E E E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 309 EKKN------------------SLKRDKAIQGLTMALKSKEK---KVEELNSEIEKLSAA 347
E+K L+ D AI+G A+K K ++++ E+E A+
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 348 ----FAKAREALQKAQTQE---FQGSEDYETALSGK-----------EALSAALRSQNLT 389
FA A+E +KA++ E Q ED A + E L+++L +N
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 390 KSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDCT 435
+ E RL I ++ +EL + Q Q+ E+L +L K +
Sbjct: 1728 QD-EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
+ L + ++LR++++E E A+++++KS ++ K+ E+ ++ + +K +
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE---QEAREKQAATKS 1843
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
+KD ++ + L+ ED E + E+ Q G+ + +++ EE +
Sbjct: 1844 LKQKDKKLKE---ILLQVED-----ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 556 VLKKEQDIYTHLVKSLQESDS----INNLQAELNK 586
+ + + L ++ + +++ +N L+++L +
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 893
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1126
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1181 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1352
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1463
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1464 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1516
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1562
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1677
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1678 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1732
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1733 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1782
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1783 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1828
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1889 AEEESQRINANRRKLQR 1905
Score = 77.0 bits (188), Expect = 2e-13
Identities = 218/1220 (17%), Positives = 467/1220 (38%), Gaps = 148/1220 (12%)
Query: 296 EEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREAL 355
EE+++ KE E+ K+ K + LK E+K +L E L +E L
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEEKNLL-------QEQL 896
Query: 356 QKAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHR---LRRSIKKITQELSDL 411
Q A+T+ + +E+ L+ K + L L E R L+ KK+ Q++ DL
Sbjct: 897 Q-AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEV---EKLRNEVNEREKAMENRYKSLLSES 468
+++ E E ++ EK + I+ L +E+ + N++++ K +E R +S+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER----ISDL 1011
Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKC 528
L +E+ K+LT+ N+ + ++ +E ++ + ++ E L+ + EG ++
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKRKLEGDASD-- 1066
Query: 529 SSQQPPGSKTIFSKEKKQSSDYEELIQV----LKKEQDIYTHLVKSLQESDS-INNLQAE 583
+Q + ++ K Q + EE +Q L E + +K ++E + I++LQ +
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 584 LNKIFALRKQLEQ---DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
L+ A R + E+ D+ KT E + ++E + + + L L+E
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 641 NRFQVEHFSQ-EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699
R H +Q +E+++K + Q V+EL + K+ +L D+ T
Sbjct: 1187 TR---SHEAQVQEMRQKHA---QAVEELTEQLEQFKRAKANL-----------DKNKQTL 1229
Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
+ E A E + E+ + Q E+ S G L K+ +
Sbjct: 1230 EKEN-ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN- 1287
Query: 760 DGAHAPGCLEE--GAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGE 817
+ G L E G I L + + ++ L +++ L + R+ L L + E
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 818 HLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGL-KDASVQTV 876
L + ++ + K L + T + + KL A V+A E K K+ T
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 877 ATEGDLLRF-KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKK 935
E + K E T+ +++ + + +++ + ++N E K+
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----------------VSNLEKKQ 1450
Query: 936 SRLPILIKPSRSLGNMY--RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993
+ L+ +++ + Y + + +++ L L L+E ++L + + +
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
A ME L++++ VG + ++ ++T
Sbjct: 1511 AEMED-------LVSSKDDVGKNVHELEKSKRALET------------------------ 1539
Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113
+ + + E ED L T A + + K Q+ + L+
Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSS 1173
+++H+ ETELE + + A +K K D +++ +
Sbjct: 1596 RQLHEYETELEDERK----------------------QRALAAAAKKKLEGDLKDLELQA 1633
Query: 1174 LHQVRYVKH-VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
++ + +K L L +M D R LE+ + +E ++ + L +++ LQ
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 1232 NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVD 1291
R + ++ + EL+ + G ++ + I EE L+ +
Sbjct: 1694 EDLAAAERARKQADLEKE--ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESP 1351
E +++ + + E+L +S + + + +ER ++ + H + +
Sbjct: 1752 M---EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 1352 EPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRL 1409
+ ++ E + +++ E + + + + L ++ +++ R + ++
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
+E + KQL+RQ E + S I A+ +L L + +NA+ K
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 1470 SRDKQKENDKLRESLSRKTV 1489
R + R S R+ +
Sbjct: 1929 RRGNETSFVPSRRSGGRRVI 1948
Score = 72.4 bits (176), Expect = 4e-12
Identities = 103/466 (22%), Positives = 197/466 (42%), Gaps = 85/466 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1492 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1542
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1543 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1659 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488
E +N + ++ R +ESN+ + + +K N+
Sbjct: 1889 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 62.8 bits (151), Expect = 3e-09
Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 908 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 965 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1016 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1064
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1110
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1111 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137
L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+
Sbjct: 1168 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181
Q E L G + Q+ K K SDGE +V ++
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235
+ +L + I ++ + +L QL++ + LQ+E + + +++ L+ +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293
L + + Q R +S Q+ D S++ + E L +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1399
Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409
S+ +A D++ E E + S +E E +
Sbjct: 1460 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1499
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
EE +TN+ L+ ++E S + +H L K +AL + +
Sbjct: 1500 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1544
Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
++ D+L+ + K ++Q + + + ++ EK R Q+ + E
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1602
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563
+ +++E K R + KL L+ +EL+A
Sbjct: 1603 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Score = 60.1 bits (144), Expect = 2e-08
Identities = 229/1176 (19%), Positives = 445/1176 (37%), Gaps = 175/1176 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 852 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 907 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1018
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1071
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1072 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1112
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1113 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1154 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1213 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1325
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1563 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1737 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER-- 1507
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R
Sbjct: 1843 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1508 -----LQKEGSEKERHNQQLIQEVRCSGQELSRVQE 1538
LQ+E E N+ + +EV +L R E
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1656
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1657 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 47.8 bits (112), Expect = 1e-04
Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%)
Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153
DQ+ + S E + L+++I DL T L E +N KH + L E +
Sbjct: 992 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213
+ L K K +G+ F H +I + +++ E LK QL ++E +L
Sbjct: 1050 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1092
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261
Q ++ +N K R+L D + + Q R+L + + +K
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310
+ S Q + + KA +E ++ + V E Q+ EL E
Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1210
Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357
+LE+ K ++ + +E+ D + ++ E+
Sbjct: 1211 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417
SD E + + K NE E + M+N ++ ++ +++ +L +L+++ +
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1321
Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477
+L ++ RQ + + L L E+ + + ++ + I+ S K+K
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531
D L E R +E+L ++Y ++L+K + ++ L+ ++ Q
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566
+S ++++ + QLL++ + R E +A EK
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Score = 39.3 bits (90), Expect = 0.035
Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%)
Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341
EE+ D E Q+ N+ EL +K +L + ++ + EL EE +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401
E E L + E + R Q+ E +K + + L E ++E
Sbjct: 912 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 961
Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461
R++L+ T E K+LE + + ++ L+ E L ++
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1010
Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519
L L + +K K KL+ LE ++ ++E E+L++ EG + H
Sbjct: 1011 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579
Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1122
Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639
++ D DS +A K+ + L G + ++L + + ST L
Sbjct: 1123 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695
+ + + +EA ++++ +Q L E Q + A ++ + T A
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737
L+ + + AK +E ++L+ L + S E + L+ +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774
+ E + + KL K + +LQ+T +LLQ RQ+
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 865 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 918
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1157
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1215 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1379
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1380 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1428 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKL 1570
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1071
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1244
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1245 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1291
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1347
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1467 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1502 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 616 RRREEE 621
+ + EE
Sbjct: 1552 KTQLEE 1557
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 911 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 949
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 950 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 1005 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1093
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1145
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1146 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1426
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1427 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1590
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDER 1616
Score = 79.3 bits (194), Expect = 3e-14
Identities = 124/635 (19%), Positives = 255/635 (40%), Gaps = 129/635 (20%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1383 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1437
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 285 RNSFEERIQA------------------------------------LEEDLREKEREIAT 308
E+ +QA L+ L E E E+
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 309 EKKN------------------SLKRDKAIQGLTMALKSKEK---KVEELNSEIEKLSAA 347
E+K L+ D AI+G A+K K ++++ E+E A+
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 348 ----FAKAREALQKAQTQE---FQGSEDYETALSGK-----------EALSAALRSQNLT 389
FA A+E +KA++ E Q ED A + E L+++L +N
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 390 KSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDCT 435
+ E RL I ++ +EL + Q Q+ E+L +L K +
Sbjct: 1735 QD-EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
+ L + ++LR++++E E A+++++KS ++ K+ E+ ++ + +K +
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE---QEAREKQAATKS 1850
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
+KD ++ + L+ ED E + E+ Q G+ + +++ EE +
Sbjct: 1851 LKQKDKKLKE---ILLQVED-----ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 556 VLKKEQDIYTHLVKSLQESDS----INNLQAELNK 586
+ + + L ++ + +++ +N L+++L +
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 900
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1133
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1188 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1359
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1470
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1471 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1523
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1569
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1684
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1685 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1739
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1740 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1789
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1790 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1835
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1896 AEEESQRINANRRKLQR 1912
Score = 77.0 bits (188), Expect = 2e-13
Identities = 218/1220 (17%), Positives = 467/1220 (38%), Gaps = 148/1220 (12%)
Query: 296 EEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREAL 355
EE+++ KE E+ K+ K + LK E+K +L E L +E L
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEEKNLL-------QEQL 903
Query: 356 QKAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHR---LRRSIKKITQELSDL 411
Q A+T+ + +E+ L+ K + L L E R L+ KK+ Q++ DL
Sbjct: 904 Q-AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEV---EKLRNEVNEREKAMENRYKSLLSES 468
+++ E E ++ EK + I+ L +E+ + N++++ K +E R +S+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER----ISDL 1018
Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKC 528
L +E+ K+LT+ N+ + ++ +E ++ + ++ E L+ + EG ++
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKRKLEGDASD-- 1073
Query: 529 SSQQPPGSKTIFSKEKKQSSDYEELIQV----LKKEQDIYTHLVKSLQESDS-INNLQAE 583
+Q + ++ K Q + EE +Q L E + +K ++E + I++LQ +
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 584 LNKIFALRKQLEQ---DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
L+ A R + E+ D+ KT E + ++E + + + L L+E
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 641 NRFQVEHFSQ-EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699
R H +Q +E+++K + Q V+EL + K+ +L D+ T
Sbjct: 1194 TR---SHEAQVQEMRQKHA---QAVEELTEQLEQFKRAKANL-----------DKNKQTL 1236
Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
+ E A E + E+ + Q E+ S G L K+ +
Sbjct: 1237 EKEN-ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN- 1294
Query: 760 DGAHAPGCLEE--GAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGE 817
+ G L E G I L + + ++ L +++ L + R+ L L + E
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 818 HLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGL-KDASVQTV 876
L + ++ + K L + T + + KL A V+A E K K+ T
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 877 ATEGDLLRF-KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKK 935
E + K E T+ +++ + + +++ + ++N E K+
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----------------VSNLEKKQ 1457
Query: 936 SRLPILIKPSRSLGNMY--RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993
+ L+ +++ + Y + + +++ L L L+E ++L + + +
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
A ME L++++ VG + ++ ++T
Sbjct: 1518 AEMED-------LVSSKDDVGKNVHELEKSKRALET------------------------ 1546
Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113
+ + + E ED L T A + + K Q+ + L+
Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSS 1173
+++H+ ETELE + + A +K K D +++ +
Sbjct: 1603 RQLHEYETELEDERK----------------------QRALAAAAKKKLEGDLKDLELQA 1640
Query: 1174 LHQVRYVKH-VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
++ + +K L L +M D R LE+ + +E ++ + L +++ LQ
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 1232 NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVD 1291
R + ++ + EL+ + G ++ + I EE L+ +
Sbjct: 1701 EDLAAAERARKQADLEKE--ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESP 1351
E +++ + + E+L +S + + + +ER ++ + H + +
Sbjct: 1759 M---EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 1352 EPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRL 1409
+ ++ E + +++ E + + + + L ++ +++ R + ++
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
+E + KQL+RQ E + S I A+ +L L + +NA+ K
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 1470 SRDKQKENDKLRESLSRKTV 1489
R + R S R+ +
Sbjct: 1936 RRGNETSFVPSRRSGGRRVI 1955
Score = 72.4 bits (176), Expect = 4e-12
Identities = 103/466 (22%), Positives = 197/466 (42%), Gaps = 85/466 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1499 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1549
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1550 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1666 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488
E +N + ++ R +ESN+ + + +K N+
Sbjct: 1896 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 62.8 bits (151), Expect = 3e-09
Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 915 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 972 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1023 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1071
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1117
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1118 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137
L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+
Sbjct: 1175 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181
Q E L G + Q+ K K SDGE +V ++
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235
+ +L + I ++ + +L QL++ + LQ+E + + +++ L+ +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293
L + + Q R +S Q+ D S++ + E L +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1406
Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409
S+ +A D++ E E + S +E E +
Sbjct: 1467 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1506
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
EE +TN+ L+ ++E S + +H L K +AL + +
Sbjct: 1507 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1551
Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
++ D+L+ + K ++Q + + + ++ EK R Q+ + E
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1609
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563
+ +++E K R + KL L+ +EL+A
Sbjct: 1610 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Score = 60.1 bits (144), Expect = 2e-08
Identities = 229/1176 (19%), Positives = 445/1176 (37%), Gaps = 175/1176 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 859 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 914 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1025
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1078
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1079 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1119
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1120 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1161 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1220 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1332
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1570 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1744 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER-- 1507
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R
Sbjct: 1850 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1508 -----LQKEGSEKERHNQQLIQEVRCSGQELSRVQE 1538
LQ+E E N+ + +EV +L R E
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1663
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1664 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 47.8 bits (112), Expect = 1e-04
Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%)
Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153
DQ+ + S E + L+++I DL T L E +N KH + L E +
Sbjct: 999 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213
+ L K K +G+ F H +I + +++ E LK QL ++E +L
Sbjct: 1057 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1099
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261
Q ++ +N K R+L D + + Q R+L + + +K
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310
+ S Q + + KA +E ++ + V E Q+ EL E
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1217
Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357
+LE+ K ++ + +E+ D + ++ E+
Sbjct: 1218 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417
SD E + + K NE E + M+N ++ ++ +++ +L +L+++ +
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1328
Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477
+L ++ RQ + + L L E+ + + ++ + I+ S K+K
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531
D L E R +E+L ++Y ++L+K + ++ L+ ++ Q
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566
+S ++++ + QLL++ + R E +A EK
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Score = 39.3 bits (90), Expect = 0.035
Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%)
Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341
EE+ D E Q+ N+ EL +K +L + ++ + EL EE +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401
E E L + E + R Q+ E +K + + L E ++E
Sbjct: 919 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 968
Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461
R++L+ T E K+LE + + ++ L+ E L ++
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1017
Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519
L L + +K K KL+ LE ++ ++E E+L++ EG + H
Sbjct: 1018 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579
Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1129
Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639
++ D DS +A K+ + L G + ++L + + ST L
Sbjct: 1130 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695
+ + + +EA ++++ +Q L E Q + A ++ + T A
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737
L+ + + AK +E ++L+ L + S E + L+ +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774
+ E + + KL K + +LQ+T +LLQ RQ+
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 865 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 918
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1157
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1215 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1379
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1380 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1428 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKL 1570
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1071
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1244
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1245 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1291
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1347
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1467 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1502 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 616 RRREEE 621
+ + EE
Sbjct: 1552 KTQLEE 1557
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 911 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 949
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 950 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 1005 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1093
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1145
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1146 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1426
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1427 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1590
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDER 1616
Score = 79.3 bits (194), Expect = 3e-14
Identities = 130/609 (21%), Positives = 255/609 (41%), Gaps = 81/609 (13%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1383 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1437
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 285 RNSFEERIQALEE-DLR----------EKEREI-ATEKKNSLKRDKAIQGLTMALKSKEK 332
E+ +QA E+ LR + ER++ A +++N KR + L L E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR----RQLQRQLHEYET 1610
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
++E+ + +AA K L+ + Q + E A+ L A ++ + +
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--DFQREL 1668
Query: 393 ENHRLRR-----SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL- 446
E+ R R + K+ ++ L+ + +L++DL A R + + D +L E+
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 447 --RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKF------NE 498
RN + + ++ +E R L E ++ N E + + ++T Q + L + +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 499 KDLEVIQQNCYLMAAEDLELRS-----EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553
K+ QQ + ++ ELRS EG + K S TI + E K + E++
Sbjct: 1789 KNESARQQ----LERQNKELRSKLHEMEGAVKSKFKS-------TIAALEAKIAQLEEQV 1837
Query: 554 IQVLKKEQDIYTHLVKSLQESDS-----INNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
Q +++Q KSL++ D + ++ E ++Q E+ + L++ L
Sbjct: 1838 EQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 609 EEQISEIRR 617
EE E +R
Sbjct: 1894 EEAEEESQR 1902
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 900
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1133
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1188 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1359
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1470
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1471 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1523
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1569
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1684
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1685 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1739
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1740 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1789
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1790 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1835
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1896 AEEESQRINANRRKLQR 1912
Score = 72.0 bits (175), Expect = 5e-12
Identities = 102/458 (22%), Positives = 195/458 (42%), Gaps = 85/458 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1499 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1549
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1550 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1666 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
E +N + ++ R +ESN+ + + +K
Sbjct: 1896 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALK 1932
Score = 62.8 bits (151), Expect = 3e-09
Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 915 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 972 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1023 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1071
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1117
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1118 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137
L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+
Sbjct: 1175 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181
Q E L G + Q+ K K SDGE +V ++
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235
+ +L + I ++ + +L QL++ + LQ+E + + +++ L+ +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293
L + + Q R +S Q+ D S++ + E L +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1406
Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409
S+ +A D++ E E + S +E E +
Sbjct: 1467 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1506
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
EE +TN+ L+ ++E S + +H L K +AL + +
Sbjct: 1507 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1551
Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
++ D+L+ + K ++Q + + + ++ EK R Q+ + E
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1609
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563
+ +++E K R + KL L+ +EL+A
Sbjct: 1610 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1640
Score = 60.1 bits (144), Expect = 2e-08
Identities = 222/1172 (18%), Positives = 446/1172 (38%), Gaps = 168/1172 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 859 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 914 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1025
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1078
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1079 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1119
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1120 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1161 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1220 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1332
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1570 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1744 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R+
Sbjct: 1850 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+ +R + + G+E++ ++ +++
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1663
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1664 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 47.8 bits (112), Expect = 1e-04
Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%)
Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153
DQ+ + S E + L+++I DL T L E +N KH + L E +
Sbjct: 999 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213
+ L K K +G+ F H +I + +++ E LK QL ++E +L
Sbjct: 1057 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1099
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261
Q ++ +N K R+L D + + Q R+L + + +K
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310
+ S Q + + KA +E ++ + V E Q+ EL E
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1217
Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357
+LE+ K ++ + +E+ D + ++ E+
Sbjct: 1218 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417
SD E + + K NE E + M+N ++ ++ +++ +L +L+++ +
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1328
Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477
+L ++ RQ + + L L E+ + + ++ + I+ S K+K
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1388
Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531
D L E R +E+L ++Y ++L+K + ++ L+ ++ Q
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566
+S ++++ + QLL++ + R E +A EK
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Score = 39.3 bits (90), Expect = 0.035
Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%)
Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341
EE+ D E Q+ N+ EL +K +L + ++ + EL EE +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401
E E L + E + R Q+ E +K + + L E ++E
Sbjct: 919 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 968
Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461
R++L+ T E K+LE + + ++ L+ E L ++
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1017
Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519
L L + +K K KL+ LE ++ ++E E+L++ EG + H
Sbjct: 1018 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579
Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1129
Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639
++ D DS +A K+ + L G + ++L + + ST L
Sbjct: 1130 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695
+ + + +EA ++++ +Q L E Q + A ++ + T A
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737
L+ + + AK +E ++L+ L + S E + L+ +
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774
+ E + + KL K + +LQ+T +LLQ RQ+
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 858 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 911
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1150
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1208 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1372
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1373 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1421 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKL 1563
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1064
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1237
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1238 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1284
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1340
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1460 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1495 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 616 RRREEE 621
+ + EE
Sbjct: 1545 KTQLEE 1550
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 904 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 942
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 943 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 998 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1086
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1138
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1139 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1419
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1420 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1583
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDER 1609
Score = 79.3 bits (194), Expect = 3e-14
Identities = 130/609 (21%), Positives = 255/609 (41%), Gaps = 81/609 (13%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1376 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1430
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 285 RNSFEERIQALEE-DLR----------EKEREI-ATEKKNSLKRDKAIQGLTMALKSKEK 332
E+ +QA E+ LR + ER++ A +++N KR + L L E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR----RQLQRQLHEYET 1603
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
++E+ + +AA K L+ + Q + E A+ L A ++ + +
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--DFQREL 1661
Query: 393 ENHRLRR-----SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL- 446
E+ R R + K+ ++ L+ + +L++DL A R + + D +L E+
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 447 --RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKF------NE 498
RN + + ++ +E R L E ++ N E + + ++T Q + L + +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 499 KDLEVIQQNCYLMAAEDLELRS-----EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553
K+ QQ + ++ ELRS EG + K S TI + E K + E++
Sbjct: 1782 KNESARQQ----LERQNKELRSKLHEMEGAVKSKFKS-------TIAALEAKIAQLEEQV 1830
Query: 554 IQVLKKEQDIYTHLVKSLQESDS-----INNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
Q +++Q KSL++ D + ++ E ++Q E+ + L++ L
Sbjct: 1831 EQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 609 EEQISEIRR 617
EE E +R
Sbjct: 1887 EEAEEESQR 1895
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 893
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1126
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1181 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1352
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1463
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1464 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1516
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1562
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1677
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1678 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1732
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1733 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1782
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1783 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1828
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1889 AEEESQRINANRRKLQR 1905
Score = 72.0 bits (175), Expect = 5e-12
Identities = 102/458 (22%), Positives = 195/458 (42%), Gaps = 85/458 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1492 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1542
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1543 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1659 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
E +N + ++ R +ESN+ + + +K
Sbjct: 1889 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALK 1925
Score = 62.8 bits (151), Expect = 3e-09
Identities = 153/815 (18%), Positives = 307/815 (37%), Gaps = 123/815 (15%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 908 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 965 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1016 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1064
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1110
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1111 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137
L +K + V D+ E+ + + + ++QK + +L +LE ++ L K+
Sbjct: 1168 LRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 1138 QCSEAIITVLCGT-----EGAQDGLSKPKN-----------GSDGEEMTFSSLHQVRYVK 1181
Q E L G + Q+ K K SDGE +V ++
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 1182 H-----VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR 1235
+ +L + I ++ + +L QL++ + LQ+E + + +++ L+ +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 1236 DLSPPRYDSLVQSQ--ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYC 1293
L + + Q R +S Q+ D S++ + E L +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSD-------SKKKLQDFASTVEALEEGKKRFQK 1399
Query: 1294 VAEGFQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
E +Q + A +KLEK L + V+++ Q +L+ +E+ + LL E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409
S+ +A D++ E E + S +E E +
Sbjct: 1460 EKNISSKYA--------------DERDRAEAEAREKETKALSLARALEEALEAK------ 1499
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
EE +TN+ L+ ++E S + +H L K +AL + +
Sbjct: 1500 EELERTNKMLKAEMEDLVSS---------------KDDVGKNVHELEKSKRALETQMEEM 1544
Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
++ D+L+ + K ++Q + + + ++ EK R Q+ + E
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE-- 1602
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLR-VELKA 1563
+ +++E K R + KL L+ +EL+A
Sbjct: 1603 ----TELEDERKQRALAAAAKKKLEGDLKDLELQA 1633
Score = 60.1 bits (144), Expect = 2e-08
Identities = 222/1172 (18%), Positives = 446/1172 (38%), Gaps = 168/1172 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 852 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 907 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1018
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1071
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1072 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1112
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1113 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1154 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1213 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1325
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1563 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1737 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R+
Sbjct: 1843 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+ +R + + G+E++ ++ +++
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1656
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1657 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 47.8 bits (112), Expect = 1e-04
Identities = 98/520 (18%), Positives = 200/520 (38%), Gaps = 81/520 (15%)
Query: 1098 DQSESINTSNETEYLKQKIHDLETEL----EGYQNFIFQLQKHSQCSEAIITVLCGTEGA 1153
DQ+ + S E + L+++I DL T L E +N KH + L E +
Sbjct: 992 DQNNKL--SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 1154 QDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL 1213
+ L K K +G+ F H +I + +++ E LK QL ++E +L
Sbjct: 1050 RQELEKLKRKLEGDASDF----------HEQIAD------LQAQIAE-LKMQLAKKEEEL 1092
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYD------------SLVQSQARELSLQRQQIK 1261
Q ++ +N K R+L D + + Q R+L + + +K
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 1262 DGHGICVIS-----------RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE 1310
+ S Q + + KA +E ++ + V E Q+ EL E
Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ--VQEMRQKHAQAVEELTE 1210
Query: 1311 KLEKLFLNGKSVGVEMNTQNELMERIEED-------------NLTYQHLLPESPEPSASH 1357
+LE+ K ++ + +E+ D + ++ E+
Sbjct: 1211 QLEQF----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417
SD E + + K NE E + M+N ++ ++ +++ +L +L+++ +
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNE-AEGKAIKLAKDVASLSSQLQDT----Q 1321
Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477
+L ++ RQ + + L L E+ + + ++ + I+ S K+K
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 1478 D------KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ 1531
D L E R +E+L ++Y ++L+K + ++ L+ ++ Q
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 1532 ELSRVQEEVKLRQQLLSQNDKLLQSL-----RVELKAYEK 1566
+S ++++ + QLL++ + R E +A EK
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Score = 39.3 bits (90), Expect = 0.035
Identities = 100/517 (19%), Positives = 198/517 (38%), Gaps = 61/517 (11%)
Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNL 1341
EE+ D E Q+ N+ EL +K +L + ++ + EL EE +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 1342 TYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQE 1401
E E L + E + R Q+ E +K + + L E ++E
Sbjct: 912 RLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQQMLD-----LEEQLEE 961
Query: 1402 IRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQA 1461
R++L+ T E K+LE + + ++ L+ E L ++
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDE-----------ILVMDDQNNKLSKERKLLEERISD 1010
Query: 1462 LNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQK--EGSEKERHN 1519
L L + +K K KL+ LE ++ ++E E+L++ EG + H
Sbjct: 1011 LTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579
Q + + + ++ ++E +L+ L +D++ Q + A +K+ E + D
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ----KNNALKKIRELEGHISD--- 1122
Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639
++ D DS +A K+ + L G + ++L + + ST L
Sbjct: 1123 --LQED-----LDSERAARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 1640 WASKNGRHVLGLIEDYEALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPA 1695
+ + + +EA ++++ +Q L E Q + A ++ + T A
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 1696 PLSKFVSSVSTAKLTLEEAYRRLK-----LLWRVSLPEDGQCPLHCE------------- 1737
L+ + + AK +E ++L+ L + S E + L+ +
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 1738 QIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQE 1774
+ E + + KL K + +LQ+T +LLQ RQ+
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 107 bits (266), Expect = 1e-22
Identities = 314/1646 (19%), Positives = 623/1646 (37%), Gaps = 263/1646 (15%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL------ 117
E Q LKKEN +K + E + + + +++I E+E+LK EL
Sbjct: 89 EQQCLSLKKENIKMKQEV----EDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 118 --QEREQLLIKASKAVESLAEAGGS-EIQRVKEDARKKVQQ----VEDLLTKRILLLEKD 170
+++ L + +A+ + E + Q ED KK+Q+ + ++IL L+K
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204
Query: 171 VTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAM-ALVLDEKDRLIEELKLS 229
+ A E ++ T+ + + + + + E L + A+ +E L+ +++ S
Sbjct: 205 LDATTDEKKETV--TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262
Query: 230 LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-----KE 284
K EA I L E K + E S ++ E + T A ++Q +
Sbjct: 263 AKEHEAEINKLNELKENLVKQCE-ASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 321
Query: 285 RNSF-----EERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNS 339
N+F E+++ LE+ L+E E ++S+ +D+ + LK L
Sbjct: 322 ENTFVEQVVNEKVKHLEDTLKE------LESQHSILKDEVTYMNNLKLK--------LEM 367
Query: 340 EIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
+ + + F RE L+ + E+ + ++ A L Q +++R +
Sbjct: 368 DAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQ 427
Query: 400 SIKKITQE---------LSDLQQER-------ERLEKDLEEAHREKSKGDCTIRDLRNEV 443
S+K+ Q+ LSD ++E+ + L++ E +EK + LR +
Sbjct: 428 SLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM 487
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E L+ E+ E + ++S+ + +H +Q ++ + +KD LL+ N E
Sbjct: 488 EILQTELGESAGKISQEFESMKQQQASDVHELQQKLR---TAFTEKDALLETVNRLQGE- 543
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI-FSKEKKQSSDYEELIQVLKKEQD 562
N L++ ++L E I + Q+ G + S+ + E I L +E+D
Sbjct: 544 ---NEKLLSQQELVPELENTIK---NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD 597
Query: 563 IYTHLVK-SLQESDSINN-LQAELNKIFALRKQLEQDVLSYQNLRKT-------LEEQIS 613
+ + +K S +E D+ + + E I L K++EQ + L + LEE +
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK 657
Query: 614 EIRRREEE------SFSLYSDQTSYLSI----CLEENNRFQVEH----------FSQEE- 652
E + +++ + S+ LS EENN+ E SQ+E
Sbjct: 658 EKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED 717
Query: 653 --LKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGF----QGNGFPDRLASTEQTELLAS 706
LK+ ++ L + ++ + + +L K + + Q GF + S E+
Sbjct: 718 VILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS----EVSED 773
Query: 707 KEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPG 766
E++D + + LQ E + +++ C + R + K+ + +
Sbjct: 774 SEEKDVVNV-------------LQAVGESLAKINEEKCNLAFQR--DEKVLELEKEIK-- 816
Query: 767 CLEEGAFI------NLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820
CL+E + + +LL EK L R +L ++ E Q L E + + E
Sbjct: 817 CLQEESVVQCEELKSLLRDYEQEKVLL----RKELEEIQSEKEALQSDLLEMKNANEKTR 872
Query: 821 GKTEKTPKQKGEL--------VHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDAS 872
+ + Q E+ +H + F K H+ LK E + ++ + LKD+
Sbjct: 873 LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSL 932
Query: 873 VQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGV---------------PG 917
++ + + D L E EEK N + + E ++ +
Sbjct: 933 AKSPSVKNDPLSSVKEL-----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
Query: 918 WQAALLSLPGI-TNREAKKSRLPILIKPSRSLGNMY--------RLPATQEVVTQLQSQI 968
Q L + + ++ + + LI+ + S N+ +L +E + +I
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 969 LELQGELK----EFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQ 1024
+L +L+ + +T N L E + + +L Q
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ-------------- 1093
Query: 1025 KGIKTTSSVWRDKEMDSDQ-QRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLS 1083
+ DKE+++++ Q+ +I ++L L + + L T L
Sbjct: 1094 -----RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
Query: 1084 SK-SQPSAKVSVMGTDQSESINTSNETEYLK-QKIHDLETELEGYQNFIFQLQKHSQCSE 1141
K +Q + +++ D + N+ K KI DLE E++ Q QK E
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK------IQKQKQETLQE 1202
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE- 1200
I ++ + ++ +K K VK K L D +L+
Sbjct: 1203 EITSLQSSVQQYEEKNTKIKQ---------------LLVKTKKELADSKQAETDHLILQA 1247
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
+LK +LE + +++ + ++ SE H + + + +L Q R +LQ +
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASD--VDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
++ + + ++ L Q + + EG +++ L+++L K+ L
Sbjct: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KIKLQ 1366
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQH--LLPE--SPEPSASHALSDYETSEKSFFS-RD 1373
+++N + E D L +H +L E S E L ++ S
Sbjct: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHT 1426
Query: 1374 QKQDNETEKTSVMVNSFS---QDLLMEHIQEIRTLRKRLEE----------------SIK 1414
Q T + V+ NSF + L EH + + TL+++L + +
Sbjct: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVS 1486
Query: 1415 TNEKLRKQLERQGSE--FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRD 1472
+ + L+ ER+ ++ + T G + ++ T + Q+L +L
Sbjct: 1487 SQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL------ 1540
Query: 1473 KQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE 1532
KL L + E L ++ +S + + L E E N L+++++ E
Sbjct: 1541 -NSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSE 1599
Query: 1533 LSRV---QEEVKLRQQLLSQNDKLLQ 1555
+ R+ QE K L + LLQ
Sbjct: 1600 IRRLERNQEREKSAANLEYLKNVLLQ 1625
Score = 99.8 bits (247), Expect = 2e-20
Identities = 295/1523 (19%), Positives = 591/1523 (38%), Gaps = 261/1523 (17%)
Query: 195 LESKLSEMKKMH----EGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACP 250
LE ++ E++ GD+ AL + D L+ L+ E QCL +K +
Sbjct: 51 LEKEIEELRSKPVTEGTGDIIKALT-ERLDALL------LEKAETEQQCLSLKKENIKMK 103
Query: 251 DENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEK 310
E S G + +E E + + + KE + + + A+ E + + +
Sbjct: 104 QEVEDSVTKMG-------DAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQL 156
Query: 311 KNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQK---AQTQEFQ--- 364
+ ++ + + E V++L EIEK+ F + LQK A T E +
Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216
Query: 365 ---------GSEDYETALSGKEALSAALRSQNLTKSTE-NHRLRRSIKKITQELSDLQQE 414
S+ Y+ ++ + L++ + + E ++ S K+ E++ L +
Sbjct: 217 TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNEL 276
Query: 415 RERLEKDLEEAHRE-KSKGDCTIRDLR---------NEVEKLRNEVNEREKAMENRYKSL 464
+E L K E + + + K +C + +LR N++ + + N + + N
Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
Query: 465 LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR----- 519
L ++ K+L +Q ++K N + L E D + I+ + EDLE +
Sbjct: 337 LEDTLKELESQHSILKDEVTYMNNLKLKL----EMDAQHIKDE-FFHEREDLEFKINELL 391
Query: 520 ----SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESD 575
+G + EK S+ +K ++ + + + L + +KE S E +
Sbjct: 392 LAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKE 451
Query: 576 SIN---NLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632
+ +Q + L+++ ++ +L+Y++LR+ +E +E+ ES S +
Sbjct: 452 KLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL----GESAGKISQEFES 507
Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
+ +++ V +L Q ++ +T+ L +T+ L G
Sbjct: 508 M----------------KQQQASDVHELQQKLRTAFTEKDALLETVNRL-------QGEN 544
Query: 693 DRLASTEQTELLASKEDEDTIK-IGEDDEINFLSDQHLQQSNEIMKDL-----SKGGCKN 746
++L S Q EL+ E E+TIK + E + + LS L Q + ++K+L S K+
Sbjct: 545 EKLLS--QQELV--PELENTIKNLQEKNGVYLLS---LSQRDTMLKELEGKINSLTEEKD 597
Query: 747 GYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806
++ ++ + D H EE + L +K ++ +L + V EL G
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILEL-----GKKVEQTIQYNSELEQKVNELTGG- 651
Query: 807 LFLTEQEVSGEHLDGKTEKTPKQKGELVH------------FVQTNSFSKPHDELKLSCE 854
L E + D K EK Q L + + N S +L E
Sbjct: 652 --LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
Query: 855 AQLVKAGEV---PKVGLKDASVQTVATEGDLLR--FKHEATREAWEE-------KPINTA 902
L + +V + + +Q + E D L ++E ++ + + K + +
Sbjct: 710 VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSE 769
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGIT--------NREAKKSRLPILIKPSRSLGNMYRL 954
+S + +++ V QA SL I R+ K L IK + ++ +
Sbjct: 770 VSEDSEEKDVVNV--LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE-ESVVQC 826
Query: 955 PATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVG 1014
+ ++ + + + L+ EL+E ++ + L L+ + E ++ LL V
Sbjct: 827 EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS 886
Query: 1015 AAYQDS----PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPE 1070
S E+ IK ++ E + R E+ I D LA PS K +P
Sbjct: 887 QTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL---ILLKDSLAKSPSVKNDPL 943
Query: 1071 DVLSP-----TSVATYLSSKSQPSAKVSVMGTDQSESINTS-NETEYLKQKIHDLETE-- 1122
+ ++ K + K+ ++ + +++S ET+ +K+++ L +E
Sbjct: 944 SSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 1123 ------------LEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKN-------- 1162
E Y+N + + +K S+ + E + L++
Sbjct: 1004 QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 1163 -GSDGEEM--TFSSLHQVRYVKHVKILG-PLAPEMIDSRV-LENL--KQQLEEQEYKLQK 1215
SD E++ +L + V+IL A M+D + E L +Q+++E + +
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
+ L +QL E LQ ++L LV+ A++ +L +I D + Q +
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQEL------ELVKKDAQQTTLMNMEIADYERLMKELNQKLT 1177
Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER 1335
E+L Q + E QE E+ + +++
Sbjct: 1178 NKNNKIEDLEQEIKIQKQKQETLQE------------------------EITSLQSSVQQ 1213
Query: 1336 IEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLL 1395
EE N + LL ++ + L+D + +E E E + V + L
Sbjct: 1214 YEEKNTKIKQLLVKTKK-----ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQL- 1267
Query: 1396 MEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI---FASGSELHSSLTSE- 1451
EI + + ++ E +KT+ +Q +R S + Q T++ + +++TSE
Sbjct: 1268 ----AEITSEKHKIHEHLKTS---AEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320
Query: 1452 ------IHFLRKQ--NQALNAMLIKGSRDKQKENDKLRESLSRK-----------TVSLE 1492
+H + KQ N++++ +G++ +++ + L + L K L+
Sbjct: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380
Query: 1493 HLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS--GQELSRVQEEVKLRQQLLSQN 1550
LQ E+ ++ E + ++ +E KE ++E CS + + E + QL SQN
Sbjct: 1381 TLQSEHDTLLERHNKMLQETVSKEAE----LREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436
Query: 1551 DKLLQSLRVELKAYEKLDEEHRR 1573
+ L S R +++ L EEHR+
Sbjct: 1437 EVLRNSFRDQVR---HLQEEHRK 1456
Score = 98.2 bits (243), Expect = 6e-20
Identities = 270/1336 (20%), Positives = 535/1336 (40%), Gaps = 196/1336 (14%)
Query: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR 384
M ++ + + EL EIE+L + K T+ G+ D AL+ E L A L
Sbjct: 39 MLIQKAKSRCTELEKEIEELRS----------KPVTE---GTGDIIKALT--ERLDALLL 83
Query: 385 SQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE 444
+ T+ + L++ K+ QE+ D + K+LE++H K I +L+NE+
Sbjct: 84 EKAETEQ-QCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK---EIENLKNELM 139
Query: 445 KLRNEVNEREKAMENRYKSL------LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
+R++ +E + ++ + + LSE K +N E +K L E + ++ E
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEK----IRPGFE 195
Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLK 558
+ + +Q+ E E ++ + +SQ +K +S EEL+Q+
Sbjct: 196 EQILYLQKQLDATTDEKKETVTQLQNIIEANSQH---------YQKNINSLQEELLQLKA 246
Query: 559 KEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQL-EQDVLSYQNLRKTLEEQISEIRR 617
Q+ L+ ++ S + +AE+NK+ L++ L +Q S +N++K E ++ +R+
Sbjct: 247 IHQEEVKELMCQIEASAKEH--EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRK 304
Query: 618 REEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKT 677
+ + SI L+EN F ++ + +KV L +KEL + + LK
Sbjct: 305 ATSNA----NQDNQICSILLQENT------FVEQVVNEKVKHLEDTLKELESQHSILKDE 354
Query: 678 I---------FDLSCMGFQGNGFPDRL-ASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
+ ++ + F +R + ELL +KE++ + E+ L+ Q
Sbjct: 355 VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414
Query: 728 H---LQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEK 784
++Q N ++ L + K E+ +SD + E L EK
Sbjct: 415 FCYTVEQHNREVQSLKEQHQKE-ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEK 473
Query: 785 ATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVH--------- 835
+L + L+ + E+L +L + ++S E E +Q+ VH
Sbjct: 474 QEAILNY--ESLREIMEILQTELGESAGKISQEF-----ESMKQQQASDVHELQQKLRTA 526
Query: 836 FVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQ--------TVATEGDLLRFKH 887
F + ++ + + L+ E L + VP++ ++Q +++ +L+
Sbjct: 527 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 586
Query: 888 EATREAWEEKP--INTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS 945
EEK IN ++ +N H ++ ++ IL
Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH-----------------KKCEREERLIL---- 625
Query: 946 RSLGNMYRLPATQEVVTQLQSQILELQGELKEF---KTCNKQLHQKLILAEAVMEGRPTP 1002
LG ++ T + ++L+ ++ EL G L+E K N Q +KL++ V+ +
Sbjct: 626 -ELGK--KVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL----SE 678
Query: 1003 DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASL 1062
DK +L+A+ V + Y+++ K S RD E+ Q+ + I + L
Sbjct: 679 DKEVLSAE--VKSLYEENNKLSSEKKQLS---RDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 1063 PSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETE 1122
+++ + L L K+Q + MG++ SE + L+ L
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793
Query: 1123 LEGYQNFIFQ-------LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLH 1175
E N FQ L+K +C + V C ++ S ++ + + L
Sbjct: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQC-----EELKSLLRDYEQEKVLLRKELE 848
Query: 1176 QVRYVKHVKILGPLAPEMIDSRVLE----NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
+++ K E + S +LE N K +LE Q +Q E+ SEIHN +
Sbjct: 849 EIQSEK----------EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898
Query: 1232 NK-----FRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
K +L P L Q + R+ + +KD + + +K EE ++
Sbjct: 899 EKCFIKEHENLKP----LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954
Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHL 1346
+ +C E EK+ K+ L E+++ + + ++E+ + L
Sbjct: 955 NLE-------------KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEE---LESL 998
Query: 1347 LPESPEPSAS-HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTL 1405
E + SAS L S K+ +KQ + + N+F + + + +++R
Sbjct: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNF-EHRIEDLTRQLRNS 1057
Query: 1406 RKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM 1465
+ E NE L ++E S I + + E+ + Q +
Sbjct: 1058 TLQCETINSDNEDLLARIETLQSNAKLLEVQILEV-QRAKAMVDKELEAEKLQKE----Q 1112
Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER---LQKEGSEKERHNQQL 1522
IK E ++L+ L ++ L+ +E VK++ ++ + E ++ ER ++L
Sbjct: 1113 KIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 1523 IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPM 1582
Q++ ++ +++E+K+++Q + + SL+ ++ YE+ + + ++L K
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKK-- 1230
Query: 1583 ESDNSFDLFDSSQAVT 1598
+L DS QA T
Sbjct: 1231 ------ELADSKQAET 1240
Score = 83.6 bits (205), Expect = 2e-15
Identities = 297/1476 (20%), Positives = 562/1476 (38%), Gaps = 230/1476 (15%)
Query: 60 MKDFENQITELKKENF---NLKLRIYFLEERMQQEFHGPTEHI-YKTNIELKVE------ 109
+K+ E+Q + LK E NLKL++ + ++ EF E + +K N L +
Sbjct: 341 LKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400
Query: 110 VESLKRELQEREQLLI----KASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRIL 165
+E LK EL + + ++ V+SL E EI + E ++ + L I
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM--KKMHEGDLAMALVLDEKDRLI 223
L++ Q E ++A E+ + + L+++L E K E + + L
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 224 EELKLSLKSKEALIQC---LKEEKSQMACPDENVSSGE-----------LRGLCAAPREE 269
++L+ + K+AL++ L+ E ++ E V E + L + R+
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580
Query: 270 KERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKS 329
+E E +E++ F +++ E++ ++ E++ L+ K ++
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 330 KEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT 389
E+KV EL +E+ + + L+K Q SED KE LSA
Sbjct: 641 LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED-------KEVLSA-------- 685
Query: 390 KSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK---- 445
+K + +E + L E+++L +DLE +K D +++ ++EK
Sbjct: 686 ----------EVKSLYEENNKLSSEKKQLSRDLEVFLSQKE--DVILKEHITQLEKKLQL 733
Query: 446 LRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDV--LLQKFNEKDLEV 503
+ E + K +EN L + +++ ++E + +KDV +LQ E ++
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793
Query: 504 IQQNCYLMAAED---LELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560
++ C L D LEL E KC ++ S + K DYE+ +L+KE
Sbjct: 794 NEEKCNLAFQRDEKVLELEKE----IKCLQEE---SVVQCEELKSLLRDYEQEKVLLRKE 846
Query: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEE-----QISEI 615
L+E S +A + + ++ E+ L QNL +EE SEI
Sbjct: 847 ----------LEEIQS--EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI 894
Query: 616 RRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVS---DLIQLVKELYTDNQ 672
+E+ F + L E +R ++ L K S D + VKEL +
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954
Query: 673 HLKKTIFDLSCMGFQGNGFPDRLASTE-QTELLASKEDEDTIKIGEDDEINFLSDQHLQQ 731
+L+K C + +L + + + EL +S+++ T+K +E+ L + Q
Sbjct: 955 NLEK-----ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK----EELESLRSEK-DQ 1004
Query: 732 SNEIMKDLSKG--GCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNE--KATL 787
+ M+DL +G KN L + E + D E +L L N +
Sbjct: 1005 LSASMRDLIQGAESYKNLLLEY-EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 788 LLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHD 847
+ DLL + L L Q + + +K + + K
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAE-------------KLQK 1110
Query: 848 ELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEH 907
E K+ A V E +V L+ Q T +L K +A + T ++ E
Sbjct: 1111 EQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQ--------TTLMNME- 1161
Query: 908 RPENLHGVPGWQAALLSL-PGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQS 966
+ ++ + L +TN+ K L IK + + QE +T LQS
Sbjct: 1162 -------IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ-----KQETLQEEITSLQS 1209
Query: 967 QILELQGELKEFKTC----------NKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAA 1016
+ + + + + K +KQ ++ +A ++G + + A
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
Query: 1017 YQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPT 1076
+ TS+ + + + QQR + E C+ + + T
Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE------------CRAAKAEQATVT 1317
Query: 1077 S------VATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQN-- 1128
S V + K Q + +S Q+E+ E E+L+ I L+ +L+ QN
Sbjct: 1318 SEFESYKVRVHNVLKQQKNKSMS-----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 1129 --FIFQLQ----KHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKH 1182
+ +LQ +H E +L T + L + E M S +H
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS-------EH 1425
Query: 1183 VKILGPLAP--EMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPP 1240
+ + L E++ + + ++ EE ++ Q ++ +++ L+N+ P
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE------P 1479
Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQE 1300
S V SQ +L+ ++ D + M+T+ + E ++ +D E
Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTD------LPLLDMHTVTREEGEGMETTDT---------E 1524
Query: 1301 QLNQCAELLEKLEKLFLNGKSVGVEMN------TQNELMERIEEDNLTYQHLLPESPEPS 1354
++ + + LE+L LN +E T+ EL++++ + HL E
Sbjct: 1525 SVSSASTYTQSLEQL-LNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETE 1583
Query: 1355 ASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIK 1414
A++A+ + R +++ E EK++ + LL + + R+RL I
Sbjct: 1584 ATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVIN 1643
Query: 1415 TNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450
T +L S +G + A G E ++S +S
Sbjct: 1644 TMLQL--------SPEEKGKLAAVAQGEEENASRSS 1671
Score = 65.9 bits (159), Expect = 4e-10
Identities = 116/573 (20%), Positives = 233/573 (40%), Gaps = 94/573 (16%)
Query: 55 TRARNMKDFENQITELK--KENFNLKLRIYFLEERMQQEFHGPT-EHIYKTNIELKVEVE 111
T N K E QI E++ K + +L L++ + + H T + + ++L+ E +
Sbjct: 1077 TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136
Query: 112 SLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKV----QQVEDL------LT 161
L++ +QE E L+K +L ++ +R+ ++ +K+ ++EDL
Sbjct: 1137 QLQKTMQELE--LVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 162 KRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDR 221
++ L++++T+ Q+ +++ K L ++ + +L++ K+ E D
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA------------ETDH 1242
Query: 222 LIEELKLSLKSK-EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQME 280
LI L+ SLK + EA Q ++ K Q+A + + + + + +
Sbjct: 1243 LI--LQASLKGELEASQQQVEVYKIQLA-------------EITSEKHKIHEHLKTSAEQ 1287
Query: 281 HQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSK---EKKVEEL 337
HQ+ +++++R+ AL+E+ R + E AT + + K+K + + E
Sbjct: 1288 HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA 1347
Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRL 397
E E L + + LQ +Q + +T S + L L
Sbjct: 1348 KQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL-----------------L 1390
Query: 398 RRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAM 457
R K + + +S + RE+L E KS+ T+ L ++ E LRN ++ + +
Sbjct: 1391 ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450
Query: 458 ENRYKSLLSESNKKLHNQE-QVIKHLTESTNQKDVL-------LQKFNEKDLEVIQQNCY 509
+ ++ + ++L E Q+ + E T + V L++ DL ++ +
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 510 L------MAAEDLELRS---------EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
M D E S E L+ + +PP F+K EEL+
Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK--------EELV 1562
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKI 587
Q L HL L+E+++ N + E K+
Sbjct: 1563 QKLSSTTKSADHLNGLLRETEATNAILMEQIKL 1595
Score = 59.3 bits (142), Expect = 3e-08
Identities = 144/683 (21%), Positives = 264/683 (38%), Gaps = 91/683 (13%)
Query: 1158 SKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEE-QEYKLQKE 1216
S K G +E+ S ++ V+ ++++K +A S NL++QLEE +L+
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKN-ELMAVRSKYSEDKANLQKQLEEAMNTQLELS 167
Query: 1217 QNLNMQLFSE--IHNLQNKFRDLSPPRYDSLVQSQAR---ELSLQRQQIKDGHGICVISR 1271
+ L Q SE + LQ + + P + ++ Q + +++ + I +
Sbjct: 168 EQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANS 227
Query: 1272 QHMNTMIKAF-EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330
QH I + EELLQ + QE++ EL+ ++E + K E+N N
Sbjct: 228 QHYQKNINSLQEELLQLKAIH-------QEEVK---ELMCQIEA---SAKEHEAEINKLN 274
Query: 1331 ELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF--FSRDQKQDNETEKTSVMVN 1388
EL E L + E S + YE ++ + + QDN+ + N
Sbjct: 275 ELKEN-----------LVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQEN 323
Query: 1389 SFSQDLLMEHIQEIRTLRKRLEE---------SIKTNEKLRKQLERQG--SEFVQGSTSI 1437
+F + ++ E ++ + K LE + N KL+ +++ Q EF +
Sbjct: 324 TFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL 383
Query: 1438 FASGSELH----------SSLTSEIHFLRKQN----QALNAMLIKGSRDKQKENDKLRES 1483
+EL L SE+ L KQ + N + QKE +L E+
Sbjct: 384 EFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNET 443
Query: 1484 -LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQL--IQEVRCS--GQELSRVQE 1538
LS L E +KE+ E LQ+E E + + L I E+ + G+ ++ +
Sbjct: 444 FLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQ 503
Query: 1539 EVK-LRQQLLSQNDKLLQSLRVE-------LKAYEKLDEEHRRLRDGDKYPMESDNSFDL 1590
E + ++QQ S +L Q LR L+ +L E+ +L + E +N+
Sbjct: 504 EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563
Query: 1591 FDSSQAVTPKSVSETPPLSGN---DTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRH 1647
V S+S+ + +SL+ + + H + R
Sbjct: 564 LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623
Query: 1648 VLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTA 1707
+L L K++ Q + +E++ + E + L K + L K + +
Sbjct: 624 IL-------ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL 676
Query: 1708 KLTLEEAYRRLKLLW---------RVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEK 1758
E +K L+ + L D + L ++ +K +T+L KKL +
Sbjct: 677 SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736
Query: 1759 KLQNTMKLLQLSKRQEKVIFDQL 1781
+ N KLL+ + Q+ + QL
Sbjct: 737 EQDNLNKLLENEQVQKLFVKTQL 759
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 105 bits (261), Expect = 5e-22
Identities = 160/748 (21%), Positives = 304/748 (40%), Gaps = 87/748 (11%)
Query: 43 LLPNVSEETVSPTRARNMKDFENQITELKKENFNLKL-RIYFLEERMQQEFHGPTEHIYK 101
L +EET +K+ + K NL +I L+ R G +
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS 605
Query: 102 TN-----IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
T+ +E K ++ ELQ + QL +K + ++ E + ++ ++ +KV++
Sbjct: 606 TSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN 665
Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH-EGDLAMALV 215
L + LE+ + LE+ F + + + ++ +MH E D A
Sbjct: 666 STLQQR----LEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 216 LDEKDRLIEELKLSLKSKEALIQCL--KEEKSQMACPDENVSSGELRGLCAAPREEKERE 273
EK LIEEL L++K+ L L KEE+ + E EL L A +EE
Sbjct: 722 DREKGALIEEL---LQAKQDLQDLLIAKEEQEDLLRKRER----ELTALKGALKEE---- 770
Query: 274 TEAAQMEHQKERNSFEERIQALEEDLRE--KEREIATEKKNSLKRDKAIQGLTMALKSKE 331
+ E K + ++ +QAL E + E K E+ + N+ ++D+A G M +K +
Sbjct: 771 VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA--GTEMRVKLLQ 828
Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED---YETALSGKEALSAALRSQNL 388
++ E+L E+L A+ + ++ + E + E YE + E R +
Sbjct: 829 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888
Query: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRN 448
+ L ++ LS QE+++L + L+E +K + +R L+NE+E R
Sbjct: 889 EAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ----LRRLKNEMENERW 944
Query: 449 EVNEREKAMENRYKSLLSES-NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
+ + + ++ ++ S L Q Q+ ++ ++ + + ++ EK LE +
Sbjct: 945 HLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR 1004
Query: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYE---------ELIQVLK 558
M +D E + + +Q +K ++ + +YE + +++K
Sbjct: 1005 LTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVK 1064
Query: 559 KEQDIYTHLVKSLQES---------------DSINNLQAELNKIFALRKQLEQDVLSYQN 603
+ +D + L L+E + + L+ EL + A R+ LE D +S +
Sbjct: 1065 QMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLER 1124
Query: 604 LRKTLEEQISEIR---RREEESFSLYSD-QTSYLSICLEENNRFQVE-HFSQEELKKKVS 658
K L+ +I + R +E + + + + L LE R + S L++KV
Sbjct: 1125 QNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVK 1184
Query: 659 DLIQLVKELYTDNQHLKKT------IFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDT 712
+L+ V D++HL T L M Q + + E ++ +E E+
Sbjct: 1185 ELVMQV-----DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
Query: 713 IKIGEDDEINFLSDQHLQ-QSNEIMKDL 739
+ + E HLQ Q N + KDL
Sbjct: 1240 MDMNE----------HLQGQLNSMKKDL 1257
Score = 70.1 bits (170), Expect = 2e-11
Identities = 103/491 (20%), Positives = 222/491 (45%), Gaps = 69/491 (14%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117
+N++ ++ +++ ++R+ L+E ++ G +E + + +L+ ++E LK +
Sbjct: 801 KNVEVLASRSNTSEQDQAGTEMRVKLLQEE-NEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 118 QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAE 177
+ ++ L K + L EA ARK ++ E + +R L E ++ AAQ
Sbjct: 860 AKAKETLKKYEGEIRQLEEA--------LVHARK--EEKEAVSARRAL--ENELEAAQGN 907
Query: 178 L-----------EKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226
L EK +E ++ LR RL++++ E ++ H G L + D +
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLR-RLKNEM-ENERWHLGKTIEKLQKEMADIVEASR 965
Query: 227 KLSLKSKEALIQCLKEEKSQMACPD----ENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
+L+ + L + ++ + ++A E E L A +++ R E ++Q
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
+ ++ + Q LE+ L++ E E+ E K+ LK D+ + +K E KV +L E+E
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYEL--EAKSHLKDDR-----SRLVKQMEDKVSQLEMELE 1078
Query: 343 K-------LSAAFAKAREALQKAQT---QEFQGSEDYETALSGKEALSAALRSQ--NLTK 390
+ LS +++RE +++ + QE +D E E + L+S+ +L
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138
Query: 391 STENHR-------------LRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437
S + + L ++ ++ ++LQ RLE+ ++E + ++
Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
Query: 438 DLRNE----VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTN--QKDV 491
D +++ ++ ++ +V E E+ ++ R +S + ++L Q + +HL N +KD+
Sbjct: 1199 DQKDQLSLRLKAMKRQVEEAEEEID-RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
Query: 492 LLQKFNEKDLE 502
L+K K L+
Sbjct: 1258 RLKKLPSKVLD 1268
Score = 54.3 bits (129), Expect = 1e-06
Identities = 145/644 (22%), Positives = 248/644 (38%), Gaps = 123/644 (19%)
Query: 1010 QPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENP 1069
QP + ++ G Q+ S+V R + + ++ E+ + A+ +N
Sbjct: 463 QPNIDGKVLETEGSQE-----STVIRAPSLGAQSKKEEEVKT--------ATATLMLQNR 509
Query: 1070 EDVLSPTSVATYLSSKSQPSAKVSVMGTD----QSESINTSNET-------EYLKQKIHD 1118
SP S A +S K+ PSA + D Q E +NE YLK+ D
Sbjct: 510 ATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTD 569
Query: 1119 LETELEGYQNFIFQ----LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE--EMTFS 1172
+ + N +F+ L+ + S C + L + K+ E E+
Sbjct: 570 NDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629
Query: 1173 SLHQVRYVKHVKI--------LGPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQ 1222
+V+ +++K L L + + +V EN L+Q+LEE E +L+K Q
Sbjct: 630 LQLEVKNQQNIKEERERMRANLEELRSQH-NEKVEENSTLQQRLEESEGELRKNLEELFQ 688
Query: 1223 LFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFE 1282
+ E Q + RDL D L + S +R + ++ + E
Sbjct: 689 VKMEREQHQTEIRDLQ----DQLSEMHDELDSAKRSEDREKGAL--------------IE 730
Query: 1283 ELLQASD--VDYCVAEGFQEQLNQCAELLEKLEKLFLNGK-SVGVEMNTQNELMERIEED 1339
ELLQA D +A+ QE +LL K E+ K ++ E+++ ++ M++++E
Sbjct: 731 ELLQAKQDLQDLLIAKEEQE------DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1340 NLTYQHLLPESPEPSASHA---LSDYETSEKSFFSRD-------------QKQDNETEKT 1383
L ES E + + S TSE+ + Q + E E+
Sbjct: 785 YDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844
Query: 1384 SVMVNSFSQDL----------LMEHIQEIRTL-------RKRLEESIKTNEKLRKQLERQ 1426
+ +DL L ++ EIR L RK +E++ L +LE
Sbjct: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 1427 GSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESL 1484
Q + +L + R +N+ N L K QKE + E+
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Query: 1485 SRKTVSLEHLQREYASVKEENER----LQKEGSEKERHNQ-------QLIQEVRCSGQEL 1533
T+ L++ EY KE+N R +Q++ EK + ++ E+R +EL
Sbjct: 965 RTSTLELQNQLDEY---KEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEEL 1021
Query: 1534 ---SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
R Q+E ++QLL Q L+ L EL+A L ++ RL
Sbjct: 1022 RDYQRAQDEALTKRQLLEQT---LKDLEYELEAKSHLKDDRSRL 1062
Score = 45.8 bits (107), Expect = 4e-04
Identities = 88/407 (21%), Positives = 164/407 (40%), Gaps = 66/407 (16%)
Query: 1208 EQEYKLQKEQNLNMQLFSE-----IHNLQNKFRDLSPP---------RYDSLVQSQAREL 1253
E KL +E+N +Q SE + LQ + DL +Y+ ++ L
Sbjct: 821 EMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
Query: 1254 SLQRQQIKDGHGICVISRQHMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312
R++ K+ V +R+ + ++A + L Q + ++E +E+ Q E L +L
Sbjct: 881 VHARKEEKEA----VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ-KEQLRRL 935
Query: 1313 EKLFLN-----GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASH-ALSDYETSE 1366
+ N GK++ +++E L Q+ L E E + A + E
Sbjct: 936 KNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995
Query: 1367 KSFFSRDQKQDNETEKTSVMVNSFSQDL-LMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425
K+ E EK+ + ++ LME +E+R ++ +E++ + L + L+
Sbjct: 996 KTL---------EAEKSRLTAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKD 1044
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
E E S L + L KQ + + L +++ +D L E +S
Sbjct: 1045 LEYEL------------EAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
Query: 1486 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEV-------RCSGQEL----- 1533
R +E L+ E + + L+ + ER N+ L + R S + L
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152
Query: 1534 SRVQE-EVKLRQQLLSQNDKLLQSLRVELKAYE---KLDEEHRRLRD 1576
+R+ E E +L + + + L + R+E K E ++D+EH L D
Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTD 1199
Score = 41.2 bits (95), Expect = 0.009
Identities = 158/831 (19%), Positives = 313/831 (37%), Gaps = 138/831 (16%)
Query: 818 HLDGKTEKTP-KQKGELVHFVQTNSFSKPHDELKLSCEAQLVK---AGEVPKVGLKDASV 873
++DGK +T Q+ ++ + SK +E+K + +++ P G K SV
Sbjct: 465 NIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISV 524
Query: 874 QTVATEG------DLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPG 927
+T + DLL+ + E T++ EE TA + L
Sbjct: 525 KTFPSASNTQATPDLLKGQQELTQQTNEE----TAKQILYN-------------YLKEGS 567
Query: 928 ITNREAKKSRLPILIKPSRSL---------GNMYRLPATQEVVTQLQS------QILELQ 972
N +A K ++ ++ + ++L GN +T EV L+ ++ ELQ
Sbjct: 568 TDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQ 627
Query: 973 GELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGE-QKGIKTTS 1031
+L+ + + ++ A +E + + + ++S GE +K ++
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1032 SVWRDKE-------------------MDS-----DQQRSYEIDSEICPPDDLASLPSCKE 1067
V ++E +DS D+++ I+ + DL L KE
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127
ED+L + + ++ G + E + E + LK++ + EL+ +
Sbjct: 748 EQEDLL-----------RKRERELTALKGALKEEVSSHDQEMDKLKEQY---DAELQALR 793
Query: 1128 NFIFQLQKHSQC----SEAIITVLCGTEGAQDGLSKPKNGSDG--EEMTFSSLHQVRYVK 1181
+ + K+ + S GTE L + G EE+ R ++
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 1182 HVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHN-LQNKFRDLSPP 1240
+K G A + E +QLEE +KE+ + + N L+ +LS
Sbjct: 854 DLK--GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 1241 RYDSLVQSQA-RELSLQRQQIKDGHGICVISRQHMNTMI----KAFEELLQAS-----DV 1290
+ S+ +E S Q++Q++ R H+ I K ++++AS ++
Sbjct: 912 TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLEL 971
Query: 1291 DYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPES 1350
+ E ++ + AE+ +L++ L + + + M +EE+ YQ E+
Sbjct: 972 QNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA 1031
Query: 1351 --PEPSASHALSD--YETSEKSFFSRDQKQ--DNETEKTSVMVNSFSQ-----DLLMEHI 1399
L D YE KS D+ + +K S + + DLL E I
Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERI 1091
Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLE-------RQGSEF------VQGSTSIFASG----- 1441
R ++L + R+ LE RQ + ++GS G
Sbjct: 1092 SRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQM 1151
Query: 1442 ----SELHSSLTSEIHF---LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL 1494
+EL L SE L+ N+ L + + E+ L + + ++ L+ +
Sbjct: 1152 EARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAM 1211
Query: 1495 QREYASVKEENERLQKEGSEKERH-NQQLIQEVRCSGQELSRVQEEVKLRQ 1544
+R+ +EE +RL+ + +R +Q+ GQ L+ ++++++L++
Sbjct: 1212 KRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ-LNSMKKDLRLKK 1261
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 104 bits (260), Expect = 7e-22
Identities = 296/1426 (20%), Positives = 569/1426 (39%), Gaps = 239/1426 (16%)
Query: 206 HEGDLAMALVLDEKDRL---IEELKLSLKSKEALIQCLKEE-------KSQMACPDENV- 254
H G+ +AL D+ L +++L+ SLK ++ + LK+E + Q A PD V
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131
Query: 255 -SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEK--- 310
SS EL+ L E++ E AQ E+ I+ +++ +K ++ATE
Sbjct: 132 DSSAELQSL--------EQQLEEAQTENFN--------IKQMKDLFEQKAAQLATEIADI 175
Query: 311 KNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYE 370
K+ +++++ ++ E+KV L E+ K + +Q +T+ Q +
Sbjct: 176 KSKYDEERSLR------EAAEQKVTRLTEELNKEATV-------IQDLKTELLQRPGIED 222
Query: 371 TALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKS 430
A+ KE + N+T E R +K+ E LQ + E + + E +
Sbjct: 223 VAVLKKELVQVQTLMDNMTLERE-----RESEKLKDECKKLQSQYASSEATISQLRSELA 277
Query: 431 KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490
KG + E++KL++ VNE + + ++LL + +E KH ES ++K+
Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE---KHNEESVSKKN 334
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
+ ++KDL+ Q L A+E R ++EK + Q K K++ S+
Sbjct: 335 I-QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ---------KLKEELSEV 384
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSIN-NLQAELN----KIFALRKQL--------EQD 597
E Q LK E + L + +E + LQ+E+N K+ +QL EQ
Sbjct: 385 ETKYQHLKAE---FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
Query: 598 VLSYQNLRKTLEEQISEIR----RREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE-- 651
LS + L E+Q+++++ R EE+ ++ T + + Q + Q+
Sbjct: 442 QLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
Query: 652 --ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE- 708
+L++ +DL Q+++++ +Q ++ +L + Q + L E+ +L A +
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQ----NLEAL-LQKSKENISLLEKEREDLYAKIQA 555
Query: 709 -DEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS---KGGCKNGYLRHTESKISDCDGAHA 764
+ +T + + E N + + Q E +K+ S K +N + + E K AH
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK------AHL 609
Query: 765 PGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTE 824
+ + L NE + L ES+ + QL + + + L +
Sbjct: 610 RAAQDR---VLSLETSVNELNSQLNESKEK---------VSQLDIQIKAKTELLLSAEAA 657
Query: 825 KTPKQKGELVHFVQT--NSFSKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGD 881
KT Q+ +L + + T N+ EL K++ + V A L+D E
Sbjct: 658 KT-AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA------KLQDKQEHCSQLESH 710
Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPIL 941
L +K + LS E + E L G Q L + + +K+ L L
Sbjct: 711 LKEYKEK-------------YLSLEQKTEELEG----QIKKLEADSLEVKASKEQALQDL 753
Query: 942 IKPSRSLGNMYRLPATQ---------EVVTQLQSQILELQGELKEFK-TCNKQLHQKLIL 991
+ R L L AT+ E+V+ + + + L+ K KQ +K IL
Sbjct: 754 -QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 992 A---EAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDK-EMDSDQQRSY 1047
E + + + L N Q E++ + T S +DK SD ++
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 1048 EIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSN 1107
+ + E A++ ++ +++ V + K Q K S+
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL------------- 919
Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167
E K+ H L+ EL Q + Q Q + +E + Q +++ K S+ +
Sbjct: 920 --EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK------EEQQLQGNINELKQSSEQK 971
Query: 1168 EMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN-LKQQLEEQEYKLQKEQNLNMQLFSE 1226
+ +L G L ++ LEN L+QQL + +L E+ L +
Sbjct: 972 KKQIEALQ-----------GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1227 IHNLQNKFRDLSPPRY--DSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEEL 1284
Q F+ L Y +S + + ++L +++ + +R + K +EL
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 1285 LQA-SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTY 1343
A + ++ A+ Q+ +C L + ++ L K + +N +++L E IEE
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL---VNEKSKLAE-IEEIKCRQ 1136
Query: 1344 QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIR 1403
+ + + E SH L E+ ++ +D KQ +K + + S +E
Sbjct: 1137 EKEITKLNEELKSHKL---ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ----- 1188
Query: 1404 TLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN 1463
KR ++ +K ++++K+ E EF++ ++LHS +
Sbjct: 1189 --EKRNQQILK--DQVKKEEEELKKEFIE-------KEAKLHSEI--------------- 1222
Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLI 1523
++K+ K E+ ++ T+ + L +VK+E + Q+ SE E+ L
Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 1524 QEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE-LKAYEKLD 1568
E+ + Q+E + + + + ++ L+ + L+ KLD
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
Score = 92.0 bits (227), Expect = 5e-18
Identities = 287/1346 (21%), Positives = 525/1346 (39%), Gaps = 228/1346 (16%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++ E Q+ E + ENFN+K E++ Q L E+ +K + E
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ---------------LATEIADIKSKYDE 181
Query: 120 REQLLIKASKAVESLAEAGGSE---IQRVKED------------ARKKVQQVEDLLTKRI 164
L A + V L E E IQ +K + +K++ QV+ L+
Sbjct: 182 ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIE 224
L E++ + E +K + + +A +L S+L+ +G +A+ + E +L
Sbjct: 242 LERERESEKLKDECKKLQSQYASSEATISQLRSELA------KGPQEVAVYVQELQKLKS 295
Query: 225 EL-KLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQK 283
+ +L+ K++ LK+E+ +++ + A +K+ + + Q
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
Query: 284 ERNSFEERIQALEE--DLREKEREIATEKKNSLKRDKA-IQGLTMALKSKEKKVEELNSE 340
S L E + +K +E +E + + KA + L + KE+ +L SE
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 341 IEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR----------SQNLTK 390
I +L + + L +A + + + L KE A L+ + +T
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 391 STENHRLRRSIKKITQELSDLQQ----ERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446
STE K+ QE LQQ + + DLE+ R+ D I++L ++K
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 447 RNEVNEREKAMENRY---------KSLLSESNKKLHNQEQVIKHLTES-TNQKDVLLQKF 496
+ ++ EK E+ Y ++L++ +K H ++ + LTE NQ + Q
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 497 NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQV 556
+V +Q +L AA+D L E + E S+ SKEK D IQ+
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNEL-------NSQLNESKEKVSQLD----IQI 644
Query: 557 -LKKEQDIYTHLVKSLQESDSINNL----------QAELNKIFALRKQLEQDVLSYQNLR 605
K E + K+ Q +D N+L Q ELNKI QL+Q Q+ +
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI---TTQLDQVTAKLQDKQ 701
Query: 606 KTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK 665
+ + S ++ +E+ SL +T L + + + + + K++ +Q +
Sbjct: 702 EHCSQLESHLKEYKEKYLSL-EQKTEELE---GQIKKLEADSLEVKASKEQALQDLQQQR 757
Query: 666 ELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTI--KIGEDDEINF 723
+L TD L+ +LS + + S+ + +L E ++I K+ + +E
Sbjct: 758 QLNTD---LELRATELS----KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--- 807
Query: 724 LSDQHLQQSNEIMKDLSKGGCKNGYLRHTE--SKISDCDGAHAPGCLEEGAFINLLAPLF 781
Q L+Q E + +K ++H E ++I + L +
Sbjct: 808 -EKQILKQDFETLSQETK-------IQHEELNNRIQ--------------TTVTELQKVK 845
Query: 782 NEKATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKT-----EKTPKQKGELV 834
EK L+ L + D L V + L ++ E E+ GK EKT K EL
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKN----SKSEFEKENQKGKAAILDLEKTCK---ELK 898
Query: 835 H--FVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE 892
H VQ + K ELK S E + +A K+ L Q + + L K E
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTL---KQNEKEE 954
Query: 893 AWEEKPIN-TALSAEHRPENLHGVPG-WQAALLSLPGITNR------------EAKKSRL 938
+ IN S+E + + + + G + A+L + N+ A+K ++
Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 939 PILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILA-EAVME 997
+ L N Y +QE QLQS + EL + K + +KL LA E ++
Sbjct: 1015 SV-------LQNNYE--KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 998 GR---PTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRD---------KEMDSDQQR 1045
R +K + + QDS +++ ++ +D KE+ +++ +
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125
Query: 1046 SYEIDSEICPPD-DLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESIN 1104
EI+ C + ++ L +E L T L Q + + +++S+
Sbjct: 1126 LAEIEEIKCRQEKEITKLN--EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183
Query: 1105 TSNETE-----YLKQKIHDLETELEGYQNFIFQLQK-HSQCSEAIITVLCGTEGAQDGLS 1158
+ E E LK ++ E EL+ + FI + K HS+ E + G+
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELK--KEFIEKEAKLHSEIKEKEV-----------GMK 1230
Query: 1159 KPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQN 1218
K + M ++L++ LG + E S + +LE+Q L+ E
Sbjct: 1231 KHEENEAKLTMQITALNE--------NLGTVKKEWQSS---QRRVSELEKQTDDLRGEIA 1279
Query: 1219 LNMQLFSEIHNLQNKFRDLSP---PRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
+ L + + N Q++ R L + + Q + L LQR+ + + R++ +
Sbjct: 1280 V---LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336
Query: 1276 TMIKAFEEL----LQASDVDYCVAEG 1297
IK + L + ++V C+A G
Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCMACG 1362
Score = 76.6 bits (187), Expect = 2e-13
Identities = 150/735 (20%), Positives = 315/735 (42%), Gaps = 93/735 (12%)
Query: 48 SEETVSPTR---ARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--- 101
SE T+S R A+ ++ + EL+K LK + L ++ Q TE++ K
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQK----LKSSVNELTQKNQTL----TENLLKKEQ 316
Query: 102 --TNIELKVEVESL-KRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVED 158
T +E K ES+ K+ +Q + ++S A + + R+ + +K + +
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 159 LLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE 218
L + + +E +AE ++ E ++ L+L+S+++++ L E
Sbjct: 377 L-KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK----------LLE 425
Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
+R + E LK + L ++ ++ V+ +L+ L + KE+ T + +
Sbjct: 426 TERQLGEAHGRLKEQRQL------SSEKLMDKEQQVADLQLK-LSRLEEQLKEKVTNSTE 478
Query: 279 MEHQKERNSFE-ERIQALEEDLREKEREIATEKKNSLK----RDKAIQGLTMAL-KSKE- 331
++HQ ++ + + QAL++ K RE + + L+ +D+ IQ L L KSKE
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Query: 332 -----KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386
K+ E+L ++I+ A + +K T + Q ++ E + E+ A +
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA--QE 596
Query: 387 NLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIR--------- 437
NL + + ++ + L+ L L E+ + S+ D I+
Sbjct: 597 NLHDQVQEQKAH--LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 438 ---------DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488
DL+N ++ +N + ++++ + N+ + L + KL +++ E +Q
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQEL-NKITTQLDQVTAKLQDKQ-------EHCSQ 706
Query: 489 KDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS 548
+ L+++ EK L ++Q + + +L ++ L K S +Q + ++++ ++
Sbjct: 707 LESHLKEYKEKYLS-LEQKTEELEGQIKKLEADSL-EVKASKEQ---ALQDLQQQRQLNT 761
Query: 549 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
D E L K+ ++ +V S + +LQ + + +++++L + Q L++
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTR-----LDLQKKSEALESIKQKLTKQEEEKQILKQDF 816
Query: 609 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK-EL 667
E E + + EE + + L E E + ++ KVSD ++ K E
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 668 YTDNQHLKKTIFDL--SCMGFQGNGFPDRLAST--EQTELLASKEDEDTIKIGEDDEINF 723
+NQ K I DL +C + + ++ +T EQ EL S E E E+N
Sbjct: 877 EKENQKGKAAILDLEKTCKELK-HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 724 LSDQHLQQSNEIMKD 738
+ +Q +Q N + ++
Sbjct: 936 MQEQLIQAQNTLKQN 950
Score = 76.3 bits (186), Expect = 3e-13
Identities = 145/759 (19%), Positives = 330/759 (43%), Gaps = 118/759 (15%)
Query: 59 NMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ 118
++ + +Q+ E K++ L ++I E + T +L+ +++ + LQ
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ----RADLQNHLDTAQNALQ 677
Query: 119 EREQLLIKASKAVESLA------EAGGSEIQRVKEDARKK---VQQVEDLLTKRILLLEK 169
+++Q L K + ++ + + S+++ ++ ++K ++Q + L +I LE
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 170 DVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLS 229
D +A E+A + ++ L LE + +E+ K L+ + ++ +L
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ----------LEMEKEIVSSTRLD 787
Query: 230 LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
L+ K ++ +K++ ++ + + +++ E ++ +++H++ N +
Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQIL------------KQDFETLSQETKIQHEELNNRIQ 835
Query: 290 ERIQALEEDLREKE---REIATEK------KNSLKR-----DKAIQGLTMALKSKEKKVE 335
+ L++ EKE E++T K +SLK +K Q A+ EK +
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 336 ELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST--E 393
EL +++ K ++ L+K+ +E + S + L+ + +++QN K E
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQNEKE 953
Query: 394 NHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTI--------RDLRNEVEK 445
+L+ +I ++ Q +++ E L+ +L+ A +K++ + + ++L E EK
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 446 LRNEVNEREKAMENRYKSLLSE---SNKKLHNQEQVIKHLTE--STNQKDVLLQKFNEKD 500
+ N EK+ E +K L S+ +L Q +K + E S Q+D++ + +
Sbjct: 1014 ISVLQNNYEKSQET-FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 501 LEVIQQNCYLMAA--EDLELRSEGLITEKCSS-QQPPGSKTIFSK----EKKQSSDYEEL 553
+ Q A E + E + E+C + Q K++ K EK + ++ EE+
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132
Query: 554 -----IQVLKKEQDIYTHLVKSLQESDSINNLQAEL--------NKIFALRKQLEQDVLS 600
++ K +++ +H ++S++E ++ + + L K +L+ +EQ+ +
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 601 YQNLRKTLEEQISEIR--------------RREEESFSLYSDQTSYLSI---CLEEN--- 640
Q L+ ++++ E++ + +E + + + L++ L EN
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 641 --NRFQVEHFSQEELKKKVSDL---IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL 695
+Q EL+K+ DL I +++ +NQ ++ + + C+ +G G ++L
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE-RCL--KGEGEIEKL 1309
Query: 696 ASTEQTELLASKEDEDTIKIGE-DDEINFLSDQHLQQSN 733
T+ E L K D T + E E L +H Q N
Sbjct: 1310 -QTKVLE-LQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346
Score = 71.2 bits (173), Expect = 8e-12
Identities = 249/1251 (19%), Positives = 477/1251 (38%), Gaps = 222/1251 (17%)
Query: 385 SQNLTKSTENHR-LRRSIKKITQELSDLQQERERLEKDLEEAHRE-------KSKGDCTI 436
S+ L K E ++ L++ K ++D E + LE+ LEEA E K +
Sbjct: 106 SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA 165
Query: 437 RDLRNEVEKLRNEVNERE---KAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLL 493
L E+ ++++ +E +A E + L E NK+ + + L + +DV +
Sbjct: 166 AQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAV 225
Query: 494 QKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE--KCSSQQPPGSKTIFSKEKKQSSDYE 551
K ++ + N L + E SE L E K SQ TI + + +
Sbjct: 226 LKKELVQVQTLMDNMTL----ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281
Query: 552 ELIQVLKKEQDIYTHLVKSLQESDSIN-NLQAELNKIFALRKQLEQDVLSYQNLRKTLEE 610
E+ +++ Q + + + + Q++ ++ NL + L ++ ++ +S +N++ TL +
Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ 341
Query: 611 QISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTD 670
+ + ++ + L + +TS I +E + + + +EEL E+ T
Sbjct: 342 KDLDCQQLQSR---LSASETSLHRIHVELSEKGEATQKLKEELS-----------EVETK 387
Query: 671 NQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQ 730
QHLK E +L +E+++ + EIN L + L+
Sbjct: 388 YQHLK----------------------AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425
Query: 731 QSNEIMKDLSKGGCKNGYLRH----TESKISDCDGAHAPGCLEEGAFINLLAPLFNEKAT 786
++ G +G L+ + K+ D + A L+ ++ L EK T
Sbjct: 426 TERQL-------GEAHGRLKEQRQLSSEKLMDKEQQVADLQLK----LSRLEEQLKEKVT 474
Query: 787 LLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPH 846
E + L K ++ Q E+ +Q G+ +Q
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ-------- 526
Query: 847 DELKLSCEAQLVKAGEVPKVGLKD-----ASVQTVATEGDLLRFKHEATREAWE------ 895
+ EA L K+ E + K+ A +Q E +L E E
Sbjct: 527 -----NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLT 581
Query: 896 EKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLP 955
EK N + S + ENLH Q A L A + R+ L L + +L
Sbjct: 582 EKLKNQSESHKQAQENLHDQVQEQKAHL--------RAAQDRVLSLETSVNELNS--QLN 631
Query: 956 ATQEVVTQLQSQI---LELQGELKEFKTCNK-QLHQKLILAEAVMEGRPTPDKTLLNAQP 1011
++E V+QL QI EL + KT + L L A+ ++ + +
Sbjct: 632 ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 691
Query: 1012 PVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
V A QD +++ +++K + S +Q++ E++ +I K+ D
Sbjct: 692 QVTAKLQDKQEHCSQLESHLKEYKEKYL-SLEQKTEELEGQI------------KKLEAD 738
Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE---TEYLKQKIHDLETELEGYQN 1128
L + SK Q ++ Q +NT E TE KQ LE E E +
Sbjct: 739 SLEVKA------SKEQ-----ALQDLQQQRQLNTDLELRATELSKQ----LEMEKEIVSS 783
Query: 1129 FIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188
LQK S+ E+I + L+K + + F +L Q ++H
Sbjct: 784 TRLDLQKKSEALESI----------KQKLTKQEEEKQILKQDFETLSQETKIQH------ 827
Query: 1189 LAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQS 1248
E +++R+ + E Q+ K++KE L +E+ +++K +S DSL S
Sbjct: 828 ---EELNNRIQTTVT---ELQKVKMEKEA-----LMTELSTVKDKLSKVS----DSLKNS 872
Query: 1249 QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAEL 1308
++ E + Q+ K + + K +EL V + L + EL
Sbjct: 873 KS-EFEKENQKGKAA----------ILDLEKTCKELKHQLQVQ------MENTLKEQKEL 915
Query: 1309 LEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368
+ LEK + +E+N+ E + I+ N Q+ E + L +K
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQL--IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 1369 FFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGS 1428
Q + + + Q L + QE+ ++++ EK ++ ++ S
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 1429 EFVQGSTSIFASGSELHS----------SLTSEIHFLRKQNQALNAMLIKGSRDKQKEND 1478
+F + + A+ +L S L S + + QN+ + L ++++
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE-LKTAKATLEQDSA 1092
Query: 1479 KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQ-ELSRVQ 1537
K + L + +L+ +Q+E + L+++ E+ I+E++C + E++++
Sbjct: 1093 KKEQQLQERCKALQDIQKE--------KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144
Query: 1538 EEVKLRQ--------------QLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
EE+K + QLL Q LQ LKA + ++ ++++
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQI 1195
Score = 58.5 bits (140), Expect = 6e-08
Identities = 204/1078 (18%), Positives = 424/1078 (39%), Gaps = 123/1078 (11%)
Query: 575 DSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLS 634
D + L+ E+ L+ L+++ + L+K LE+ ++++E + L +D ++ L
Sbjct: 83 DDVTLLRQEVQD---LQASLKEEKWYSEELKKELEKY-QGLQQQEAKPDGLVTDSSAELQ 138
Query: 635 ICLEENNRFQVEHFSQEELK----KKVSDL---IQLVKELYTDNQHLKKTIFDLSCMGFQ 687
++ Q E+F+ +++K +K + L I +K Y + + L++ +
Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198
Query: 688 GNGFPDRLASTEQTELLASKEDEDTIKIGED-DEINFLSDQHLQQSNEIMKDLSKGGCKN 746
+ +TELL ED + ++ ++ L D ++ E + K CK
Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERESEKLKDECKK 257
Query: 747 GYLRH--TESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRP---DLLKVVRE 801
++ +E+ IS A G E ++ L L + L +++ +LLK ++
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
Query: 802 LLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN--SFSKPHDELKLSCEAQLVK 859
+ E+ VS +++ + +L + + S + H EL EA
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 860 AGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWE-EKPINTA----LSAEHRPENLHG 914
E+ +V K ++ A L + + E + + + IN L E + HG
Sbjct: 378 KEELSEVETKYQHLK--AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
Query: 915 VPGWQAALLSLP------GITNREAKKSRLPILIKP--SRSLGNMYRLPATQEVVTQLQS 966
Q L S + + + K SRL +K + S ++L T++ + Q+
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 967 -------QILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQD 1019
++ E Q +L++ QK+ EA+++ L + + A Q
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 1020 SPGE--------QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
GE +K V + E +Q S++ E + +
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 1072 VLS-PTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIH-DLETELEGYQNF 1129
VLS TSV S ++ KVS + E K DL+ L+ QN
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 1130 IFQLQKH-SQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188
+ Q+ ++ + + V + Q+ S+ ++ + + SL Q K ++ G
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ----KTEELEGQ 731
Query: 1189 LAPEMIDSRVLENLKQQ-LEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQ 1247
+ DS ++ K+Q L++ + + Q +L ++ L+ + +S R D +
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 1248 SQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAE 1307
S+A E S++++ K + + + FE L Q + + + +E N+
Sbjct: 792 SEALE-SIKQKLTKQ--------EEEKQILKQDFETLSQETKIQH------EELNNRIQT 836
Query: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEK 1367
+ +L+K+ + +++ E++T + + ++ SD + K
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKV-----------------------SDSLKNSK 873
Query: 1368 SFFSRDQKQDN----ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQL 1423
S F ++ ++ + EKT + Q + ++E + L+K LE+ + + +L+ +L
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933
Query: 1424 ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR-------KQNQALNAMLIKGSRDKQKE 1476
+ +Q ++ + E L I+ L+ KQ +AL L K +
Sbjct: 934 NSMQEQLIQAQNTLKQNEKE-EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 1477 NDKLRESLSRKTVSLEH-------LQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
+KL++ L++ L LQ Y +E ++LQ + +E Q+++
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLRV--------ELKAYEKLDEEHRRLRDGDK 1579
++LS QE++ + + +KL+Q L+ K ++L E + L+D K
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK 1110
Score = 53.9 bits (128), Expect = 1e-06
Identities = 132/681 (19%), Positives = 270/681 (39%), Gaps = 99/681 (14%)
Query: 949 GNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLN 1008
G L ++ VT L+ ++ +LQ LKE K +++L ++L + + + PD + +
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132
Query: 1009 AQPPVGAAYQ---DSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSC 1065
+ + + Q ++ E IK ++ K Q + EI D+ SL
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA----AQLATEIADIKSKYDEERSLREA 188
Query: 1066 KEN-----PEDVLSPTSVATYLSSK--SQPSAK---------VSVMGTDQSESINTSNET 1109
E E++ +V L ++ +P + V V + ++ E+
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 1110 EYLKQKIHDLETELEGYQNFIFQLQ----KHSQCSEAIITVLCGTEGAQDGLSKPKNGSD 1165
E LK + L+++ + I QL+ K Q + L + + + L++ KN +
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ-KNQTL 307
Query: 1166 GE-----EMTFSSL---HQVRYVKHVKILGPLAPEMIDSRVLEN----LKQQLEEQEYKL 1213
E E ++ L H V I L + +D + L++ + L +L
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS--R 1271
++ +L E+ ++ K++ L +++ ++L QR++ K+ HG+ + S
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHL---------KAEFKQLQQQREE-KEQHGLQLQSEIN 417
Query: 1272 QHMNTMIKAFEELLQA----SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMN 1327
Q + +++ +L +A + +E ++ Q A+L KL +L + + ++
Sbjct: 418 QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVT 474
Query: 1328 TQNELMERIEEDNLTY--QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385
EL ++++ + Q L +S A +D E + +DQK
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK---------- 524
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
IQ + L ++ +E+I EK R+ L + + +G T++
Sbjct: 525 -------------IQNLEALLQKSKENISLLEKEREDLYAK-IQAGEGETAVL------- 563
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
+ L + H L++Q L L S ++ + L + + + L Q S++
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN-----DKLLQSLRVE 1560
L + +E + QL +++ EL E K Q+ QN LQ + E
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAK-TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682
Query: 1561 L-KAYEKLDEEHRRLRDGDKY 1580
L K +LD+ +L+D ++
Sbjct: 683 LNKITTQLDQVTAKLQDKQEH 703
Score = 53.5 bits (127), Expect = 2e-06
Identities = 87/451 (19%), Positives = 182/451 (40%), Gaps = 34/451 (7%)
Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393
E ++++ YQ L + +P ++D +S + ++ E M + F Q
Sbjct: 107 EELKKELEKYQGLQQQEAKPDG--LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQK 164
Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSEL-HSSLTSEI 1452
+ EI ++ + +E E +++ R E + +T I +EL ++
Sbjct: 165 AA-QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDV 223
Query: 1453 HFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEG 1512
L+K+ + ++ + ++++E++KL++ + LQ +YAS + +L+ E
Sbjct: 224 AVLKKELVQVQTLMDNMTLERERESEKLKDECKK-------LQSQYASSEATISQLRSEL 276
Query: 1513 SEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHR 1572
++ QEV QEL +++ V +L +N L ++L + + Y KL+E+H
Sbjct: 277 AKGP-------QEVAVYVQELQKLKSSVN---ELTQKNQTLTENLLKKEQDYTKLEEKHN 326
Query: 1573 RLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETP--------PLSGNDTDSLSCDSGSSA 1624
K + + DL D Q + S SET G T L +
Sbjct: 327 EESVSKKNIQATLHQKDL-DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
Query: 1625 TSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTS 1684
T + + +H L L + L ++ + +R L E + +E +S
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 1685 QELGTKGPHPAPL----SKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIG 1740
++L K A L S+ + E +L + + ++
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLR 505
Query: 1741 EMKAEVTKLHKKLFEQEKKLQNTMKLLQLSK 1771
E + ++ ++ +++ ++++K+QN LLQ SK
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 536
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 103 bits (258), Expect = 1e-21
Identities = 139/658 (21%), Positives = 278/658 (42%), Gaps = 101/658 (15%)
Query: 60 MKDFENQITE-------LKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVES 112
+ D E+++ E L+ E ++ I LEE++ +E G + + + + +++
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGARQKLQLEKVTAEAKIKK 982
Query: 113 LKRE---LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARK--KVQQVEDLLTKRILLL 167
++ E L+++ IK K +E S++ +E A+ K++ ++++ +
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK 227
K + ELEKA + +L+ + ++++ + E I+ELK
Sbjct: 1043 LKKEEKTRQELEKA----------KRKLDGETTDLQDQ----------IAELQAQIDELK 1082
Query: 228 LSLKSKEALIQCLKEEKSQMACPDENVSS--GELRGLCAAPREEKERETEAAQMEHQKER 285
L L KE +Q N EL+ A +E+ E E +A++ + +K++
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQK 1141
Query: 286 NSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLS 345
E ++AL+ +L + A +++ KR++ + L AL+ + K E ++I+ +
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE---AQIQDMR 1198
Query: 346 AAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKIT 405
A A E L SE E A + A L T+N L +K +
Sbjct: 1199 QRHATALEEL----------SEQLEQA----KRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 406 QELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLL 465
Q ++ + +R++L+ ++E H + S+GD +L + KL+NE+ + +LL
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL--------DNVSTLL 1296
Query: 466 SESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
E+ KK + L LLQ+ + L +L R L
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL-------------NLSSRIRQLEE 1343
Query: 526 EKCSSQQPPGSKTIFSKE-KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL 584
EK S Q+ + K +KQ + + KK+ D ++SL+E+ AE
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE- 1402
Query: 585 NKIFALRKQLEQDVLSYQNLRKT---LEEQI--------------SEIRRREEESFSLYS 627
AL ++LE+ L+Y L KT L++++ S + +++++ L +
Sbjct: 1403 ----ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 628 DQTSYLSICLEENNRFQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
++ S + EE +R + E +E L + + + ++ +E N+ L+ + DL
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 95.1 bits (235), Expect = 5e-19
Identities = 131/581 (22%), Positives = 250/581 (43%), Gaps = 63/581 (10%)
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-RILLLEKDVTAAQAELE-KA 181
L++ ++ E L +A E+ +VKE K ++E++ K + LL EK++ A Q + E +
Sbjct: 844 LLQVTRQEEEL-QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 182 FAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK 241
FA E +R RL +K E++++ + +E++++++ K K +A IQ L+
Sbjct: 903 FAEAE---EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK---KKMQAHIQDLE 956
Query: 242 EEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-----KERNSFEERIQALE 296
E+ + +E A + K+ E E +E Q KE+ E+RI
Sbjct: 957 EQLDE----EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
L E+E + K K++ I L LK +EK +EL KL ++ +
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 357 KAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415
+ Q Q ++ + L+ K E L AL + +N+ L K+ +E LQ +
Sbjct: 1073 ELQAQ----IDELKLQLAKKEEELQGALARGDDETLHKNNAL-----KVVRE---LQAQI 1120
Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE--------------REKAMENRY 461
L++D E ++K + RDL E+E L+ E+ + RE+ +
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 462 KSLLSES-NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRS 520
K+L E+ N + Q+ +H T + L Q K +++N + ++ EL
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK--ANLEKNKQGLETDNKELAC 1238
Query: 521 EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNL 580
E + ++ ++ K KK + +EL + + + L ++ + L
Sbjct: 1239 EVKVLQQVKAESE-------HKRKKLDAQVQELHAKVSEGDRLRVEL------AEKASKL 1285
Query: 581 QAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
Q EL+ + L ++ E+ + + +LE Q+ + + +E + +S + EE
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
N Q + +EE +K + + ++ D + KK DL
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTK--KKVDDDL 1384
Score = 76.3 bits (186), Expect = 3e-13
Identities = 131/621 (21%), Positives = 254/621 (40%), Gaps = 105/621 (16%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEER------MQQEFHGPTEHIYKTNIELKVEVESL 113
++D + + E ++ NL RI LEE Q+E +++ K + L+ ++
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 114 KRE----------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK- 162
K++ L+E ++ L+K ++A+ E ++++ + Q+++DL
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 163 ------------------RILLLEKDVTAAQAE---------LEKAFAGTETEKALRLRL 195
++L EK ++A AE EK +AL L
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
E+K ++ + M ++ KD + + + KSK AL Q ++E ++Q+ ++ +
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Query: 256 SGELRGLCAAPREEKERETEAAQMEH--QKERNSFEERIQALEEDLREKEREIATEKKNS 313
+ E L R E + AQ E Q EE+ + L + +RE E E+ E+K
Sbjct: 1557 ATEDAKL----RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ- 1611
Query: 314 LKRDKAIQGLTMALKSK-EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETA 372
+ L +A K K E +++L ++IE A KAR+ + K + +DY+
Sbjct: 1612 -------RALAVASKKKMEIDLKDLEAQIE----AANKARDEVIKQLRKLQAQMKDYQRE 1660
Query: 373 LSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKG 432
L + A R + +S E+ + +K + E+ LQ+E E+ A +E+
Sbjct: 1661 LEE----ARASRDEIFAQSKES---EKKLKSLEAEILQLQEELASSERARRHAEQER--- 1710
Query: 433 DCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ-EQVIKHLTESTNQKDV 491
++L +E+ KS L + ++L + Q+ + L E + ++
Sbjct: 1711 -----------DELADEITNSASG-----KSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 492 LLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE--------KCSSQQPPGS-----KT 538
L +F + L+V N L A +S+ + K Q+ G+ K
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814
Query: 539 IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA--LRKQLEQ 596
S + + EE ++ KE+ LV+ ++ +Q E + A ++Q+E+
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 597 DVLSYQNLRKTLEEQISEIRR 617
+ L++ LEE E R
Sbjct: 1875 ANARMKQLKRQLEEAEEEATR 1895
Score = 68.2 bits (165), Expect = 7e-11
Identities = 113/508 (22%), Positives = 211/508 (41%), Gaps = 107/508 (21%)
Query: 57 ARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRE 116
A N++ + + +L E ++ R + EER + E + ++ +E +E
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISAR--YAEERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 117 LQEREQLLIKAS-KAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
ER+ ++A + + S + G + +++ R QQVE++ T+ LE
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ----LE------- 1549
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDR--LIEELK------ 227
ELE TE K LRLE + MK E DL +E+ + LI++++
Sbjct: 1550 -ELEDELQATEDAK---LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 228 --------LSLKSKEALIQCLKEEKSQMACP----DENVSSGELRGLCAAPREEKERETE 275
L++ SK+ + LK+ ++Q+ DE + +LR L A ++ +RE E
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK--QLRKL-QAQMKDYQRELE 1662
Query: 276 AAQM----------EHQKERNSFEERIQALEEDLREKER----------EIATEKKNSLK 315
A+ E +K+ S E I L+E+L ER E+A E NS
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722
Query: 316 RDKAIQGLTMALKSK----EKKVEELNSEIEKLSAAFAK--------------------- 350
A+ L+++ E+++EE S +E L+ F K
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK 1782
Query: 351 ---AREALQ------KAQTQEFQGS--EDYETALSGKEA----LSAALRSQNLTKSTENH 395
AR+ L+ KA+ QE +G+ ++ +S EA L L + ++ N
Sbjct: 1783 SDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANK 1842
Query: 396 RLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK 455
+RR+ KK+ + ++ ER ++ E + K + ++ L+ ++E+ E
Sbjct: 1843 LVRRTEKKLKEIFMQVEDERRHADQYKE----QMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 456 AMENRYKSL--LSESNKKLHNQEQVIKH 481
+ + L +E+N+ L + +K+
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKN 1926
Score = 62.0 bits (149), Expect = 5e-09
Identities = 152/786 (19%), Positives = 318/786 (40%), Gaps = 101/786 (12%)
Query: 1087 QPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEG-------YQNFIFQLQKHSQC 1139
Q A+ + + + + + L++ +HDLE+ +E QN ++Q H Q
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 1140 SEAIITVLCGTEGAQDGLSKPKNGSDG------EEMTFSSLHQVRYVKHVKIL------- 1186
E L EGA+ L K ++ EE+ +++K K++
Sbjct: 955 LEE---QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 1187 -GPLAPEMIDSRVLENLKQQLE----EQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPR 1241
LA E ++ L ++ + E + E +L+KE+ +L L + DL
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 1242 YDSLVQSQARELSLQ----RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG 1297
+ +Q+Q EL LQ ++++ H N +K EL QA + + E
Sbjct: 1072 AE--LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAE--LQED 1126
Query: 1298 FQEQL-------NQCAELLEKLEKL------FLNGKSVGVEMNTQNE-----LMERIEED 1339
F+ + Q +L E+LE L L+ + E+ T+ E L + +EE+
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 1340 NLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHI 1399
++ + + + HA + E SE+ ++ K + E K + ++ E
Sbjct: 1187 TKNHEAQIQDMRQ---RHATALEELSEQLEQAKRFKANLEKNKQGLETDN------KELA 1237
Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGS---TSIFASGSELHSSLTSEIHFLR 1456
E++ L++ ES +KL Q++ ++ +G + S+L + L + + L
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN-VSTLL 1296
Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKE 1516
++ + K + + + +E L +T +L ++EE LQ++ E+E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 1517 RHNQQLIQEVRCSGQELSRVQEEV-----------KLRQQLLSQNDKLLQSLRVELKAYE 1565
+ L ++V +L+ +++V + +++LL + L Q L + AY+
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 1566 KLDEEHRRL-RDGDKYPMESDNSFDL---FDSSQAVTPKSVSETPPLS---GNDTDSLSC 1618
KL++ RL ++ D ++ D+ + + Q + ++E +S + D
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 1619 DSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQE 1678
++ T ++R + + R L D E L+ + + E++ +++
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE-KSKR 1535
Query: 1679 APSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSL-----PEDGQCP 1733
A +E+ T+ L + + AKL LE + +K + L + +
Sbjct: 1536 ALEQQVEEMRTQ---LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592
Query: 1734 LHCEQIGEMKAEVTKLHKK---LFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRK 1790
L +Q+ E++AE+ K+ +KK++ +K L+ D+++ K LRK
Sbjct: 1593 LLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI---KQLRK 1649
Query: 1791 ARGNLE 1796
+ ++
Sbjct: 1650 LQAQMK 1655
Score = 53.5 bits (127), Expect = 2e-06
Identities = 114/567 (20%), Positives = 224/567 (39%), Gaps = 62/567 (10%)
Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVE-MNTQNELMERIEEDN 1340
EE LQA D + + Q ++ E +E+ + L K++ E + + EL EE
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 1341 LTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEH-- 1398
E E L D E+ + R+Q NE +K + + L E
Sbjct: 911 ARLAAKKQELEE-----ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 1399 IQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT--------- 1449
Q+++ + E IK E+ LE Q S+F++ + +E S L
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 1450 -----------SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREY 1498
S++ K+ + L K R E L++ ++ ++ L+ +
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558
A +EE + G ++ H ++ VR +++ +QE+ + + ++ +K + L
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 1559 VELKAY-----EKLD-----EEHRRLRDGD----KYPMESD---NSFDLFDSSQ--AVTP 1599
EL+A + LD +E R R+ + K +E + + + D Q A
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATAL 1205
Query: 1600 KSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALL 1659
+ +SE + +L + T ++ V +++ L + L
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 1660 KQISQGQRL---LAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSV-----STAKLTL 1711
++S+G RL LAE + Q + S L +K +S+ T +L
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 1712 EEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKA------EVTKLHKKLFEQEKKLQNTMK 1765
EE ++L L R+ E+ + L +Q E +A +V L +L + +KK+ + +
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLG 1385
Query: 1766 LLQ-LSKRQEKVIFDQLVVTHKILRKA 1791
++ L + ++K++ D ++ ++ KA
Sbjct: 1386 TIESLEEAKKKLLKDAEALSQRLEEKA 1412
Score = 49.7 bits (117), Expect = 3e-05
Identities = 193/1047 (18%), Positives = 401/1047 (38%), Gaps = 155/1047 (14%)
Query: 553 LIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQL--EQDVLSYQNLRKT--- 607
L+QV ++E+++ + L+ + ++ EL ++ +QL E+++L+ Q +T
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 608 --LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK 665
EE + + +++E + D S + EE R Q+ +++++ + DL + +
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVE---EEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 666 ELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLS 725
E G +L + T K+ E+ I + ED F+
Sbjct: 961 E---------------------EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 726 DQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKA 785
++ L E +I++C A EE LA + N++
Sbjct: 1000 EKKLM----------------------EDRIAECSSQLA----EEEEKAKNLAKIRNKQE 1033
Query: 786 TLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKP 845
++ + L K + E E + LDG+T Q EL +
Sbjct: 1034 VMISDLEERLKKEEKTR-------QELEKAKRKLDGETTDLQDQIAELQAQI-------- 1078
Query: 846 HDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSA 905
DELKL QL K E + L +T+ L + + A ++ + ++
Sbjct: 1079 -DELKL----QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 906 EHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQ 965
++ E + L + ++ + K + + + + A +E +
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK--ALEEETKNHE 1191
Query: 966 SQILEL-QGELKEFKTCNKQLHQ-KLILA--EAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+QI ++ Q + ++QL Q K A E +G T +K L + +S
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDV-LSPTSVAT 1080
++K + K + D+ R + ++L ++ + E E + A
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
L S+ Q + ++ + + + +N S+ L+++ + L+ + E + L+K
Sbjct: 1312 SLESQLQDTQEL--LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ---- 1365
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVR--YVKHVKILGP-LAPEMIDSR 1197
Q L+ K D + T SL + + +K + L L + +
Sbjct: 1366 ---------VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 1198 VLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDL-SPPRYDSLVQSQARELSLQ 1256
LE K +L+++ L + + Q+ S + Q KF L + + S ++ R+ +
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC-AELLEKLEKL 1315
+ K+ + ++ +A EE L+A E F+ Q Q A++ + +
Sbjct: 1477 EAREKETKAL---------SLARALEEALEAK-------EEFERQNKQLRADMEDLMSSK 1520
Query: 1316 FLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRD- 1373
GK+V ++ L +++EE + L E A L + K+ F RD
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
Query: 1374 QKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG 1433
Q +D + E+ ++ I+++R L LE+ E+ ++ L + ++
Sbjct: 1581 QTRDEQNEEKKRLL-----------IKQVRELEAELED-----ERKQRALAVASKKKMEI 1624
Query: 1434 STSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEH 1493
+ E + E+ KQ + L A + +D Q+E ++ R S +
Sbjct: 1625 DLKDLEAQIEAANKARDEVI---KQLRKLQAQM----KDYQRELEEARASRDEIFAQSKE 1677
Query: 1494 LQREYASVKEENERLQKEGSEKER-------HNQQLIQEVRCSGQELSRVQEEVKLRQQL 1546
+++ S++ E +LQ+E + ER +L E+ S S + +E +++L
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE---KRRL 1734
Query: 1547 LSQNDKLLQSLRVELKAYEKLDEEHRR 1573
++ +L + L E E L++ R+
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRK 1761
Score = 46.6 bits (109), Expect = 2e-04
Identities = 91/453 (20%), Positives = 179/453 (39%), Gaps = 94/453 (20%)
Query: 58 RNMKDFENQITELKKE---NFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK----VEV 110
+ +++ Q+ EL+ E + KLR+ + M+ +F + + N E K +V
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 111 ESLKRELQE--REQLLIKASKA--------VESLAEAGGSEIQRVKEDARKKVQQVEDLL 160
L+ EL++ +++ L ASK +E+ EA V + RK Q++D
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY- 1657
Query: 161 TKRILLLEKDVTAAQAELEKAFAGT-ETEKALRLRLESKLSEMKKMHEGDLAMALVLDEK 219
++++ A+A ++ FA + E+EK L+ L +++ + A E+
Sbjct: 1658 -------QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 220 DRLIEELKLSLKSKEALI--------------QCLKEEKSQMACPDEN-----VSSGELR 260
D L +E+ S K AL+ + L+EE+S M ++ + L
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 261 GLCAAPREEKERETEAAQ-MEHQKER--------------------NSFEERIQALEEDL 299
AA R ++ A Q +E Q + ++ E +I LEE L
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQL 1830
Query: 300 REKEREIATEKKNSLKRDKAIQGLTMA---------------------LKSKEKKVEELN 338
++ +E A K + +K ++ + M +K ++++EE
Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 339 SEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLR 398
E + +A+ K + L A T+ +G + L + + S+ + R +
Sbjct: 1891 EEATRANASRRKLQRELDDA-TEANEGLSREVSTLKNRLRRGGPIS----FSSSRSGRRQ 1945
Query: 399 RSIKKITQELSDLQQERERLEKDLEEAHREKSK 431
++ + ELSD + E D+ E +S+
Sbjct: 1946 LHLEGASLELSD--DDTESKTSDVNETQPPQSE 1976
Score = 40.4 bits (93), Expect = 0.016
Identities = 55/287 (19%), Positives = 123/287 (42%), Gaps = 43/287 (14%)
Query: 1484 LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE---EV 1540
++R+ L+ E VKE+ +++ E E ER +QQL++E ++L E E
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 1541 KLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMES--DNSFDLFDSSQAVT 1598
+ + L+ + L+ + +L++ + +EE ++ +K M++ + + D +
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 1599 PKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL 1658
K E T+ + ++ L +N + I++ + +
Sbjct: 967 QKLQLE------------------KVTAEAKIKKMEEEILLLEDQNSK----FIKEKKLM 1004
Query: 1659 LKQISQGQRLLAEMDIQTQE-APSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRR 1717
+I++ LAE + + + A QE+ + L + + + LE+A R+
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMI-----SDLEERLKKEEKTRQELEKAKRK 1059
Query: 1718 LKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTM 1764
L DG+ +QI E++A++ +L +L ++E++LQ +
Sbjct: 1060 L----------DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5
[Homo sapiens]
Length = 1132
Score = 103 bits (257), Expect = 2e-21
Identities = 116/488 (23%), Positives = 224/488 (45%), Gaps = 43/488 (8%)
Query: 202 MKKMHEGDLAMALVLDEKDRLIEEL---KLSLKSKEALIQCLKEEK---SQMACPDENVS 255
+K +++ ++ L L + L ++L L L+ + + LK++K + ++VS
Sbjct: 341 LKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVS 400
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
L L +EK ++TEA + L+E L E E+ +++S K
Sbjct: 401 DSHLAEL-----QEKIQQTEATN--------------KILQEKLNEMSYELKCAQESSQK 441
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
+D IQ L LKS+E++ EEL IE + AK RE L ++Q + SE T+ +
Sbjct: 442 QDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQ 499
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
++ L+S E +L+R +++ ++L+D +Q + +E E+ ++K
Sbjct: 500 QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 559
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
++LR +++L+ E+ + + + ++ +E ++ QEQ I+HL S + K+ LLQ+
Sbjct: 560 NQELRKALQQLQEELQNKSQQL----RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 615
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
F E + L A E L + I +K + + + + E+K+ + +
Sbjct: 616 FRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA 675
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS--YQNLRKTLEEQIS 613
V +++ D+ + L++ S N + + K LE + LS QNL+ EE +
Sbjct: 676 VRERDHDL-----ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
+ R ++E S+ L L + N+ +VE S L K ++ +EL Q
Sbjct: 731 KFSRWQKEQESIIQQ----LQTSLHDRNK-EVEDLSATLLCKLGPGQSEIAEELCQRLQR 785
Query: 674 LKKTIFDL 681
++ + DL
Sbjct: 786 KERMLQDL 793
Score = 69.7 bits (169), Expect = 2e-11
Identities = 144/715 (20%), Positives = 294/715 (41%), Gaps = 125/715 (17%)
Query: 26 VPDDLDGINPNAGLGNGLLPNVSEETVSP------TRARNMKDFENQITELKKENFNLKL 79
V L G P + +G+ ++ P + + D + +L ++ L++
Sbjct: 315 VKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRV 374
Query: 80 RIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGG 139
+ E QQ+ + ++T I + +S ELQE+ Q +K ++
Sbjct: 375 QPMTEELLKQQKLNS-----HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMS 429
Query: 140 SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKL 199
E++ +E ++K+ +++L ++ + + + E E+ + E + +L L
Sbjct: 430 YELKCAQESSQKQDGTIQNL--------KETLKSRERETEELYQVIEGQNDTMAKLREML 481
Query: 200 --SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL----KEEKSQMACPDEN 253
S++ ++H + ++ + +L+ +L + IQ L ++++ Q+A +
Sbjct: 482 HQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQC 538
Query: 254 VSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIAT---EK 310
V E A E E++ EA+ +Q+ R + +Q L+E+L+ K +++ EK
Sbjct: 539 VQFVE------AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQLRAWEAEK 588
Query: 311 KNSLK-RDKAIQGLTMALKSKEKKVEEL--------NSE---------IEKLSAAFAKAR 352
N ++ +++ IQ L +L KE+ ++E NS+ +EKL
Sbjct: 589 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
Query: 353 EALQKAQTQEFQGSEDYETALS-----------GKEALSAALRSQNLTKSTENHRLRRS- 400
AL++A ++F E+ E L E L L S T + LR
Sbjct: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708
Query: 401 --IKKITQELSDLQQERERLEKDLEEAHREKS----KGDCTIRDLRNEVEKLR------- 447
+++++ +LQ +E +E +E+ + ++ D EVE L
Sbjct: 709 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 768
Query: 448 --------NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499
E+ +R + E + LLS+ NK++ E I+ L +S + ++ Q EK
Sbjct: 769 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 828
Query: 500 DLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553
++ ++++N L A L S+ I+ + + P G K+ Q S
Sbjct: 829 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG---CLGKQTDQGS----- 880
Query: 554 IQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
+Q+ +D T L + +E SI + +L+ + L K+L +E++
Sbjct: 881 MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKEL-----------SNAKEEL 925
Query: 613 SEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
+ ++E ES S S +++ EE QV+ E L + + L+K+L
Sbjct: 926 ELMAKKERESQMELSALQSMMAVQEEE---LQVQAADMESLTRNIQIKEDLIKDL 977
Score = 43.1 bits (100), Expect = 0.002
Identities = 62/290 (21%), Positives = 115/290 (39%), Gaps = 47/290 (16%)
Query: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS-- 1365
L L+ L+ S +E++ EL + + ED L + + P + E L+ +ET+
Sbjct: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR-VQPMTEELLKQQKLNSHETTIT 395
Query: 1366 ----EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L++
Sbjct: 396 QQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 451
Query: 1422 QL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNAML 1466
L ER+ E ++G A E LH S ++H + A L + L
Sbjct: 452 TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL 511
Query: 1467 IKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKEEN 1505
+ QK +R ES +K S +H Q ++++
Sbjct: 512 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 571
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
E LQ + + + E+R Q + + + ++QLL + +LLQ
Sbjct: 572 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQ 621
Score = 36.2 bits (82), Expect = 0.30
Identities = 81/401 (20%), Positives = 156/401 (38%), Gaps = 48/401 (11%)
Query: 1226 EIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELL 1285
E+ +LQ + DL VQ EL +QQ + H + + ++ + +E +
Sbjct: 354 ELSDLQELWDDLCEDYLPLRVQPMTEELL--KQQKLNSHETTITQQSVSDSHLAELQEKI 411
Query: 1286 QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQH 1345
Q ++ + QE+LN+ + L+ ++ + K G N + L R E YQ
Sbjct: 412 QQTEATNKI---LQEKLNEMSYELKCAQES--SQKQDGTIQNLKETLKSRERETEELYQV 466
Query: 1346 LLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTL 1405
+ ++ +T K Q Q + + + Q L++ +++
Sbjct: 467 IEGQN------------DTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLD----LQSA 510
Query: 1406 RKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM 1465
+ I+ +++ +Q ERQ ++ Q + A+ E S E + K NQ L
Sbjct: 511 LFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHE--SEQQKEASW--KHNQELRKA 566
Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQRE-YASVKEENERLQKEGSEKERHNQQLIQ 1524
L +L+E L K+ L + E Y ++ + + +Q H +QL+Q
Sbjct: 567 L-----------QQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLS-HKEQLLQ 614
Query: 1525 EVRCSGQELSRVQEEVKLRQQLLSQ-----NDKLLQSLRVELKAYEKLDEEHRRLRDGDK 1579
E R Q + ++ + LL + +DK + R + + L+E+ + LR
Sbjct: 615 EFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRL 674
Query: 1580 YPMESDNSFDLFD---SSQAVTPKSVSETPPLSGNDTDSLS 1617
E D+ + SS T +S+ G + + LS
Sbjct: 675 AVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLS 715
Score = 36.2 bits (82), Expect = 0.30
Identities = 98/448 (21%), Positives = 178/448 (39%), Gaps = 89/448 (19%)
Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 574 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 631
Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 632 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 676
Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 677 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 736
Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
+ E+ + + ++ E E S + QDLL
Sbjct: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796
Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856
Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 857 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 914
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 915 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 974
Query: 1555 QSLRVEL------KAYEKLDEEHRRLRD 1576
+ L+++L A E+L +E LR+
Sbjct: 975 KDLQMQLVDPEDIPAMERLTQEVLLLRE 1002
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 100 bits (249), Expect = 1e-20
Identities = 310/1622 (19%), Positives = 654/1622 (40%), Gaps = 278/1622 (17%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRE- 116
+ M+ E++I ++ K+ + + L R Q++ + I + LK+E L+
Sbjct: 306 KKMEQLEDKIKDINKKLSSAENDRDILR-REQEQLNVEKRQIMEECENLKLECSKLQPSA 364
Query: 117 ------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----------- 159
+ E+E++L +++ E +Q+ DA ++ ++ L
Sbjct: 365 VKQSDTMTEKERILAQSASVEEVF------RLQQALSDAENEIMRLSSLNQDNSLAEDNL 418
Query: 160 -LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE 218
L RI +LEK+ + E E E + +L L+L ++ +K D+++
Sbjct: 419 KLKMRIEVLEKEKSLLSQEKE------ELQMSL-LKLNNEYEVIKSTATRDISL------ 465
Query: 219 KDRLIEELKLSLKSKEA-LIQCLKEEKSQMACPDE----NVSSGELRGLCAAPREEKERE 273
D + +L+L+L++KE L Q + E+++ +A +E N + + L +++ E
Sbjct: 466 -DSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524
Query: 274 TEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKK 333
++ + +++ N ++R+ LE+D + +E+ +K+ ++ + A+ L + + E K
Sbjct: 525 GDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584
Query: 334 VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT-KST 392
VE L ++ K + ++ + + +E + E + E + + + N K T
Sbjct: 585 VENLVDQLNKSQESNVSIQK--ENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642
Query: 393 ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE---------- 442
++ + Q LS+L+Q E L+K + E K D+R++
Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ 702
Query: 443 --------VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ 494
VE L+ E E E + K LL E+NK E+ I+ L+ + N LQ
Sbjct: 703 LSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANK----YEKTIEELSNARNLNTSALQ 758
Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
+E +++ Q+ +D+E+ E+ + + S ++Q ++L
Sbjct: 759 LEHEHLIKLNQK-------KDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ----KQLT 807
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF-ALRKQLEQDVLSYQNLRKTLEEQIS 613
Q++ K++ ++ L+E S LQ EL+K ALRK + LR+T+EE+
Sbjct: 808 QLINKKE----IFIEKLKERSS--KLQEELDKYSQALRKN--------EILRQTIEEKDR 853
Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
+ +EE+ L + L EE +R + + V++L V +L T +H
Sbjct: 854 SLGSMKEENNHLQEE----LERLREEQSR--TAPVADPKTLDSVTELASEVSQLNTIKEH 907
Query: 674 LKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSN 733
L++ I + N +L + Q + K++ D + + +++N Q + +
Sbjct: 908 LEEEIKHHQKIIEDQNQSKMQLLQSLQEQ----KKEMDEFRY-QHEQMNATHTQLFLEKD 962
Query: 734 EIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRP 793
E +K L K + H E + D + +E +L +EK L
Sbjct: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNS---DIFQETKVQSLNIENGSEKHDLSKAETE 1019
Query: 794 DLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQK-GELVHFVQTNSFSKPHDELKLS 852
L+K ++E L L E+ +S L + ++ K + G+L +Q E++ +
Sbjct: 1020 RLVKGIKERELEIKLLNEKNIS---LTKQIDQLSKDEVGKLTQIIQQKDL-----EIQ-A 1070
Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGD-LLRFKHEATREAWEEKPINTALSAEHRPEN 911
A++ V +Q A E + + +E TRE N+ L E+ +
Sbjct: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRE-------NSHLKTEYH-KM 1122
Query: 912 LHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQ---- 967
+ V +AAL+ L + + + ++ N+ R+ +++ SQ
Sbjct: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQT 1182
Query: 968 ---ILELQGELKEFKTCNKQLHQKLI-----LAEAVMEGRPTPDKTLLNAQPPVGAAYQD 1019
+L+ E N ++L+ L + V + + + Q ++
Sbjct: 1183 LLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQ---NMQHES 1239
Query: 1020 SPGEQKGIKTTSSVWRDKEMDSDQQ-------RSYEID------------------SEIC 1054
+ +++ + + V D + +S Q +SYE + ++C
Sbjct: 1240 AQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Query: 1055 PPDDLASLPSCKENPEDVLSP-TSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113
DL D++SP S A+ L+ +S + S +SE + S +E L+
Sbjct: 1300 NTKDLLL------GKLDIISPQLSSASLLTPQSAECLRAS-----KSEVL--SESSELLQ 1346
Query: 1114 QKIHDLETELEGYQNFIFQLQKHS-QCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS 1172
Q++ +L L+ I LQ+++ + S++I A L + ++ E T S
Sbjct: 1347 QELEELRKSLQEKDATIRTLQENNHRLSDSI--------AATSELERKEH-----EQTDS 1393
Query: 1173 SLHQVRYVKHV---------KILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223
+ Q++ + V ++ + +++ S EN ++ E E Q NL ++
Sbjct: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSN--ENFTNKVNENELLRQAVTNLKERI 1451
Query: 1224 F---SEIHNLQNKFRDL------SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHM 1274
+I L+ + + Y +L ++ + + R++ + H M
Sbjct: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS--------M 1503
Query: 1275 NTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL-----------EKLFLNGKSVG 1323
AFE+LL+ + +G +LNQ ++ + +++ L K
Sbjct: 1504 KEKALAFEQLLKEKE------QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQ 1557
Query: 1324 VEMNT--QNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+E NT QNE+ +++ + Q L E +H L ++ + + + ++ +
Sbjct: 1558 ME-NTALQNEVQRLRDKEFRSNQEL-----ERLRNHLLESEDSYTREALAAEDREAKLRK 1611
Query: 1382 KTSVMVNSF-SQDLLMEHIQ-----EIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGST 1435
K +V+ S ME+ ++ +L+++L K ++ QL + Q +
Sbjct: 1612 KVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671
Query: 1436 SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495
S+ ++L + +++ +A+ + ++ + E K E+L K +SL+
Sbjct: 1672 SL--------ANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL 1723
Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
E + + RL ++ KE +++ ++ + +LRQ++L K L
Sbjct: 1724 DEANAALDSASRLTEQLDVKE--------------EQIEELKRQNELRQEMLDDVQKKLM 1769
Query: 1556 SL 1557
SL
Sbjct: 1770 SL 1771
Score = 93.6 bits (231), Expect = 2e-18
Identities = 326/1656 (19%), Positives = 634/1656 (38%), Gaps = 288/1656 (17%)
Query: 43 LLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQ-QEFHGPTEHI-Y 100
+L +EE + K+ E L+ EN LK LEE+ + E + Y
Sbjct: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSY 96
Query: 101 KTNIELK-VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL 159
+ ++ K VE+ LK + L+K A +S+ G +
Sbjct: 97 RNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSA 156
Query: 160 LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEK 219
+ D+ ++Q E+ + RLES++ + H + A D
Sbjct: 157 FHDDDMDFG-DIISSQQEINRLSNEVS-------RLESEVGHWR--HIAQTSKAQGTDNS 206
Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM 279
D+ E KL + +I+ LK+ +SQ ++ S +++ TE ++
Sbjct: 207 DQS-EICKL-----QNIIKELKQNRSQEIDDHQHEMS-------VLQNAHQQKLTEISR- 252
Query: 280 EHQKERNSFEERIQALEEDLREK-EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELN 338
H++E + +EERI+ LE L++ I T+ + K IQ L + KK+E+L
Sbjct: 253 RHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLE 312
Query: 339 SEIEKLSAAFAKA---REALQKAQTQ----EFQGSEDYETALSGKEALSAALRSQNLTKS 391
+I+ ++ + A R+ L++ Q Q + Q E+ E L + Q+ T +
Sbjct: 313 DKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMT 372
Query: 392 TENHRLRRS-----IKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446
+ L +S + ++ Q LSD + E RL +++ S + ++ K+
Sbjct: 373 EKERILAQSASVEEVFRLQQALSDAENEIMRLSS----LNQDNSLAEDNLK------LKM 422
Query: 447 RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ------------ 494
R EV E+EK++ ++ K L S KL+N+ +VIK ST +D+ L
Sbjct: 423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK----STATRDISLDSELHDLRLNLEA 478
Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEG------LITEKCSSQQPPGSKTIFSKEKKQSS 548
K E + + ++ + E+L+ +++ LI ++ S QQ G +I SK K+ +
Sbjct: 479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGD-SIISKLKQDLN 537
Query: 549 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
D ++ + L+ ++ D L + K+ L L+ Q L +
Sbjct: 538 DEKKRVHQLEDDK------------MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
Query: 609 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQ-EELKKKVSDLIQLVKEL 667
E + ++ + +E + + +++ N EH Q EE ++ + +L++ L
Sbjct: 586 ENLVDQLNKSQESN------------VSIQKENLELKEHIRQNEEELSRIRN--ELMQSL 631
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
D+ + F D L + E+ K++ ++ ++ D
Sbjct: 632 NQDSN----------------SNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDV 675
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNE-KAT 786
++ ++ C++ +RH ++ +C + LE+ + L E +A
Sbjct: 676 KMENEKLVL------ACED--VRH---QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAE 724
Query: 787 L------LLESRPDLLKVVRELLLGQLFLTEQ-EVSGEHLDGKTEKTPKQKGELVHFVQT 839
L LLE K + EL + T ++ EHL +K + EL ++
Sbjct: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784
Query: 840 --NSFSKPHDELKLSCE-----AQLVKAGEVPKVGLKDAS--VQTVATEGDLLRFKHEAT 890
+ D L S E QL+ E+ LK+ S +Q + K+E
Sbjct: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844
Query: 891 REAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGN 950
R+ EEK + E EN H Q L L RE + P+
Sbjct: 845 RQTIEEKDRSLGSMKE---ENNH----LQEELERL-----REEQSRTAPVAD-------- 884
Query: 951 MYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNA- 1009
P T + VT+L S++ +L T + L +++ + ++E + LL +
Sbjct: 885 ----PKTLDSVTELASEVSQLN-------TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL 933
Query: 1010 --QPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKE 1067
Q ++ + T + +D+E+ S Q+ +I +++ E
Sbjct: 934 QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL------------HE 981
Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127
+D+ + S + +K Q +++ + ++ + ETE L + I + E E++
Sbjct: 982 ERQDIQTDNS-DIFQETKVQ---SLNIENGSEKHDLSKA-ETERLVKGIKERELEIKLLN 1036
Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187
L K D LSK + G L Q+ K ++I
Sbjct: 1037 EKNISLTKQI-----------------DQLSKDEVGK---------LTQIIQQKDLEIQA 1070
Query: 1188 PLAPEMIDSRVLENLKQQLEEQEYKLQKEQ-----NLNMQLFSEIHNLQNKFRDLSPPRY 1242
A S + + Q + Q Y +++E+ N + S + +K D+ +
Sbjct: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 1130
Query: 1243 DSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKA-----------FEELLQASDVD 1291
+L++ Q L + G + + Q+++ +I+ + LL
Sbjct: 1131 AALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTS 1190
Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVG--------VEMNTQNELMERIEEDNLTY 1343
E NQ ELL++ +KL K + N Q+E + EE +
Sbjct: 1191 STGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ 1250
Query: 1344 QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQ-----DLLMEH 1398
+L +S S DY +S+ + K N ++ + + +S Q DLL+
Sbjct: 1251 AQVLVDSDNNSKLQV--DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308
Query: 1399 I---------------QEIRTLRKRLEESI-KTNEKLRKQLERQGSEFVQGSTSI----- 1437
+ Q LR E + +++E L+++LE + +I
Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQE 1368
Query: 1438 --------FASGSEL----HSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKL---RE 1482
A+ SEL H SEI L+++ L +L + + ++D+L E
Sbjct: 1369 NNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNE 1428
Query: 1483 SLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKL 1542
+ + K E L++ ++KE L+ + + + N+++++ R E +QE
Sbjct: 1429 NFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK 1488
Query: 1543 RQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGD 1578
+L + + S++ + A+E+L +E + + G+
Sbjct: 1489 FSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGE 1524
Score = 74.7 bits (182), Expect = 8e-13
Identities = 143/767 (18%), Positives = 312/767 (40%), Gaps = 146/767 (19%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT------N 103
E ++ T + + + +I L+K +K +++ EER Q+ I++ N
Sbjct: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH--EER--QDIQTDNSDIFQETKVQSLN 1003
Query: 104 IE--------LKVEVESLKRELQERE---QLL----IKASKAVESLAEAGGSEIQRVKED 148
IE K E E L + ++ERE +LL I +K ++ L++ ++ ++ +
Sbjct: 1004 IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQ 1063
Query: 149 ARKKVQQVEDLL-----TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK 203
++Q + + T+ ++ L++ + A E EK FA + L+++ +M
Sbjct: 1064 KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM 1123
Query: 204 KMHEG-DLAMALVLDEKDRL---------------IEELKLSLKSKEALIQCLKEEKSQM 247
+ + A+ + DE +L I+ L ++ K+ I L ++ +
Sbjct: 1124 DIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTL 1183
Query: 248 ACPDENVSSG-ELRGLCAAPREE--KERET---EAAQMEHQKER-----NSFEERIQALE 296
+ S+G E G+ + EE +ER+ + +ME K++ + + L+
Sbjct: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243
Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
E+L + + ++ + N+ K GL + + E K++ E+ ++ + Q
Sbjct: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIG------Q 1297
Query: 357 KAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415
T++ L GK + +S L S +L LR S ++ E S+L
Sbjct: 1298 LCNTKDL---------LLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL---- 1344
Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ 475
L+++LEE + + D TIR L+ +L + + + SE +K H Q
Sbjct: 1345 --LQQELEELRKSLQEKDATIRTLQENNHRLSDSI------------AATSELERKEHEQ 1390
Query: 476 -EQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAED----------------LEL 518
+ IK L E ++DVL + EKDL + ++ L+++ + L
Sbjct: 1391 TDSEIKQLKE---KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL 1447
Query: 519 RSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL------IQVLKKEQDIYTHLVKS-- 570
+ LI E + ++ I + + ++Y+ L ++ +E++ H +K
Sbjct: 1448 KERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKA 1507
Query: 571 ------LQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---------KTLEEQI--S 613
L+E + ELN++ K +++ + +Q R K +E +
Sbjct: 1508 LAFEQLLKEKE--QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
E++R ++ F + + LE + + E + E+ + K+ + +++E + +
Sbjct: 1566 EVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSN 1625
Query: 674 LKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
+ + + + + EQ +++ + DE +++ E
Sbjct: 1626 AMENASHQASVQVE--------SLQEQLNVVSKQRDETALQLSVSQE 1664
Score = 64.3 bits (155), Expect = 1e-09
Identities = 124/674 (18%), Positives = 269/674 (39%), Gaps = 86/674 (12%)
Query: 954 LPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPV 1013
L A ++ + Q S+ L E++E N++ + +IL + + + ++++
Sbjct: 476 LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK-- 533
Query: 1014 GAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVL 1073
QD E+K + D + D Q+ I SE+ L L K+ ED +
Sbjct: 534 ----QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVA----LNDLHLTKQKLEDKV 585
Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQL 1133
V + Q +++ E LK+ I E EL +N + Q
Sbjct: 586 ENL---------------VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS 630
Query: 1134 QKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS-----------------SLHQ 1176
S T+L E L + N S+ E++ + +
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQ--NLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 1177 VRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRD 1236
VR+ + G + + ++E LK + E E +L + +L E + + +
Sbjct: 689 VRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK---RLLEEANKYEKTIEE 745
Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE 1296
LS AR L+ Q++ H I + ++ M I ++ ++ D D+ +
Sbjct: 746 LS----------NARNLNTSALQLEHEHLIKLNQKKDME--IAELKKNIEQMDTDH---K 790
Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEM--NTQNELMERIEEDN--LTYQHLLPESPE 1352
++ L+ E ++L +L +N K + +E ++L E +++ + L +L ++ E
Sbjct: 791 ETKDVLSSSLEEQKQLTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE 849
Query: 1353 PSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLME---HIQEIRTLRKRL 1409
+L + ++ E +T+ + + + D + E + ++ T+++ L
Sbjct: 850 EK-DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHL 908
Query: 1410 EESIKTNEKL--------------RKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFL 1455
EE IK ++K+ ++ +++ EF + A+ ++L EI L
Sbjct: 909 EEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSL 968
Query: 1456 RKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEK 1515
+K + + L + +D Q +N + + +++++E+ ++ K E ERL K E+
Sbjct: 969 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKER 1028
Query: 1516 ERHNQQLIQEVRCSGQELSRV-QEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
E + L ++ +++ ++ ++EV Q++ Q D +Q+L + + +
Sbjct: 1029 ELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQ 1088
Query: 1575 RDGDKYPMESDNSF 1588
+ Y ME + F
Sbjct: 1089 QQLQAYAMEREKVF 1102
Score = 53.5 bits (127), Expect = 2e-06
Identities = 152/780 (19%), Positives = 301/780 (38%), Gaps = 133/780 (17%)
Query: 1099 QSESINTSNETEYLKQKIHDLETELEGYQN---FIFQLQKHSQCSEAIITVLCGTEGAQD 1155
Q E + ++ + E L+ KI D+ +L +N + + Q+ + I C +
Sbjct: 298 QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLEC 357
Query: 1156 GLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQK 1215
+P + MT + +IL A + L+Q L + E ++ +
Sbjct: 358 SKLQPSAVKQSDTMT----------EKERILAQSA----SVEEVFRLQQALSDAENEIMR 403
Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGI--------- 1266
+LN NL+ K R + SL+ + EL + ++ + + +
Sbjct: 404 LSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDI 463
Query: 1267 ------------CVISRQHMN-------TMIKAFEEL----LQASDVDYCVAEGFQEQLN 1303
Q +N T+I EEL +A+ + + +Q N
Sbjct: 464 SLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQN 523
Query: 1304 QCAELLEKLEKLFLNGK-----------SVGVEMNTQNELMERIEEDNLTYQHLLPESPE 1352
+ ++ KL++ + K + E++ Q E + + E L HL + E
Sbjct: 524 EGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQ-SEVALNDLHLTKQKLE 582
Query: 1353 PSASHALSDYETSEKSFFS--------RDQKQDNETEKTSV---MVNSFSQD-------- 1393
+ + S++S S ++ + NE E + + ++ S +QD
Sbjct: 583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642
Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRK---QLERQGSEFVQGSTSI-------FASGSE 1443
LL E E+R L++ L E + NE L+K ++ + + V + A ++
Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ 702
Query: 1444 LHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDK----LRESLSRKTVSLEHLQREYA 1499
L + + L+ + + A L + +E +K + E + + ++ LQ E+
Sbjct: 703 LSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHE 762
Query: 1500 SVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRV 1559
+ + N++ E +E +++ +Q+ + + + LS EE K QL+++ + ++ L+
Sbjct: 763 HLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKE 822
Query: 1560 -ELKAYEKLDEEHRRLRDGD---KYPMESDNSFDLFDSSQAVTPKSV-------SETPPL 1608
K E+LD+ + LR + + E D S + + S T P+
Sbjct: 823 RSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPV 882
Query: 1609 SGNDTDSLSCDSGSSATSTPCVSRLVT-GHHLWASKNGRHVLGLIEDYE----ALLKQIS 1663
+ D + DS + S VS+L T HL + +H +IED LL+ +
Sbjct: 883 A----DPKTLDSVTELASE--VSQLNTIKEHL--EEEIKHHQKIIEDQNQSKMQLLQSLQ 934
Query: 1664 QGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWR 1723
+ ++ + E Q ++ ++ +Q K L K + + T L E + ++
Sbjct: 935 EQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT---QLHEERQDIQTDNS 991
Query: 1724 VSLPEDGQCPLHCEQIGE----MKAEVTKLHKKLFEQ--------EKKLQNTMKLLQLSK 1771
E L+ E E KAE +L K + E+ EK + T ++ QLSK
Sbjct: 992 DIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK 1051
Score = 31.6 bits (70), Expect = 7.3
Identities = 61/307 (19%), Positives = 126/307 (41%), Gaps = 43/307 (14%)
Query: 1328 TQNELMERIEEDNLTYQHLLPES--PEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385
T++ LME EE + LP+S E A HA+ E D ++ +E + +
Sbjct: 34 TKDMLMEGTEE----VEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQI 89
Query: 1386 MVNSFS-QDLLMEHIQEIRTLRKR---LEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
S S ++ L + EI L+ R L++ + + + + ++S FA G
Sbjct: 90 KQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYG 149
Query: 1442 SELHSSL--TSEIHF--LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL-QR 1496
H S ++ F + Q +N + + SR + + + + K ++ Q
Sbjct: 150 ISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS 209
Query: 1497 EYASVKEENERLQKEGSEK------------ERHNQQLIQEVRCSGQELSRVQEEVKLRQ 1544
E ++ + L++ S++ H Q+L + R +ELS +E ++ +
Sbjct: 210 EICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELE 269
Query: 1545 QLLSQN---------------DKLLQSLRVE-LKAYEKLDEEHRRLRDGDKYPMESDNSF 1588
LL Q K +Q L++E +++ +K+++ +++D +K ++N
Sbjct: 270 NLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDR 329
Query: 1589 DLFDSSQ 1595
D+ Q
Sbjct: 330 DILRREQ 336
Score = 31.6 bits (70), Expect = 7.3
Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 7/108 (6%)
Query: 44 LPNVSEETVSPTRARNMKDFENQ---ITELKKENFNLKLRIYFLEERMQQEFHGPTEHIY 100
L V E +A + E Q I E KK NL+ ++ L+E + E + +
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLD-EANAALDSAS 1734
Query: 101 KTNIELKV---EVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRV 145
+ +L V ++E LKR+ + R+++L K + SLA + ++ +V
Sbjct: 1735 RLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 100 bits (249), Expect = 1e-20
Identities = 168/750 (22%), Positives = 314/750 (41%), Gaps = 102/750 (13%)
Query: 54 PTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESL 113
P+ ++ D +Q+ + +++ +LK R+ ++Q T N E +V E +
Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV-TEEV 986
Query: 114 KRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTA 173
++ ++ R + + +E E Q +++D R+ ++ +E L++ L+K +++
Sbjct: 987 RKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSE----LKKTLSS 1042
Query: 174 AQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
Q E+++A T + + E K + ++ +++ EL L
Sbjct: 1043 VQNEVQEALQRASTALSNEQQARRDCQEQAK---------IAVEAQNKYERELMLHAADV 1093
Query: 234 EALIQCLKEEKSQMACP----DENVSSGELRGL-CAAPREEKER--ETEAAQM-----EH 281
EAL Q KE+ S+MA +E E + L C A EE+ER + E ++ +
Sbjct: 1094 EAL-QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDL 1152
Query: 282 QKERNSFEERIQALEEDLREKEREIATEKKN-SLKRDKAIQGLTMALKS---KEKKVEEL 337
+K+ ++I+ L + + +E N SL + Q + + +EK++ E
Sbjct: 1153 EKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET 1212
Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTE---- 393
E+ ++ + + R L + + QE Q S + E A + A + + L K TE
Sbjct: 1213 RFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA-QHEELMKKTETMNV 1271
Query: 394 ----NHRLRRSIKKITQELSDLQQERERLEKD---LEEAHREKSKGDCTIRDLRNEVE-- 444
N LR +++ Q+L +Q + +LE D L+EA+ E S+ ++ + +E
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEED 1331
Query: 445 ----KLRNE--VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
K RN+ V++++ Y+ LLSE K++H + I+ LTE + + + N
Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSE--KEVHTKR--IQQLTEEIGRLKAEIARSNA 1387
Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEK------------KQ 546
QN EDL + TEK + Q+ +K I +EK +
Sbjct: 1388 SLTN--NQNLIQSLKEDLNK----VRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRY 1441
Query: 547 SSDYEELIQVLKKEQDIYTHLVKSLQES----DSINNLQAELNKIFALRKQLEQDVLSYQ 602
+ YEEL K + QE + L+ LN+ K LE V +
Sbjct: 1442 KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV---E 1498
Query: 603 NLRKTLEEQISEIRRREEESFSLYSD-----QTSYLSICLEENNRFQVEHFSQE------ 651
NL+KTL E+ +E R +E++ L S+ Q EE R Q+ ++
Sbjct: 1499 NLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIV 1558
Query: 652 ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDED 711
K K++ L + +L +N+ LK Q NG D+ + A K +
Sbjct: 1559 AAKSKIAHLAGVKDQLTKENEELK-----------QRNGALDQQKDELDVRITALKSQYE 1607
Query: 712 TIKIGEDDEINFLSDQHLQQSNEIMKDLSK 741
+ E+ ++HL+Q +E + +K
Sbjct: 1608 GRISRLERELREHQERHLEQRDEPQEPSNK 1637
Score = 92.8 bits (229), Expect = 3e-18
Identities = 304/1658 (18%), Positives = 632/1658 (38%), Gaps = 212/1658 (12%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQ--EFHGPTEHIYKTNIELKVEVESLKR 115
+ + + ++ +E +L+L + L +++ E + E NI ++ + K
Sbjct: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
EL+ ++ LI+ ++ + E +++R+ E ++ +L K L DV+
Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
Query: 176 AELEKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKE 234
E E EK L + L+ E+K + LA+ EK I ELK +L++K+
Sbjct: 179 REKR-----LEQEKELLHSQNTWLNTELKTKTDELLALGR---EKGNEILELKCNLENKK 230
Query: 235 ALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKER--------- 285
+ L+E+ + + +E++ + L +E KE++ + H +
Sbjct: 231 EEVSRLEEQMNGLKTSNEHLQK-HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLY 289
Query: 286 NSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK-SKEKKVEELNSEIEKL 344
S + +A +L E+ K + + +KAIQ + ++ SK++ +E+ +I +L
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKI 404
A + L + + SE+ A+S A A + + K TE L + +
Sbjct: 350 EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM-KLTE---LYNAYVET 405
Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL 464
+L + E +R+ K L+E +E ++ R E E+ + V +E K +
Sbjct: 406 QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
Query: 465 --LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
L E K + Q V+ ++D + KDL Q ++ E E R
Sbjct: 466 QRLQEDTDKANKQSSVL--------ERDNRRMEIQVKDLS---QQIRVLLMELEEARGNH 514
Query: 523 LIT-EKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQ 581
+I E+ SS S + S+ + EEL Q + Q + L + L E+ +
Sbjct: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ---QNQRLLVAL-RELGETREREEQE 570
Query: 582 AELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRR--REEESFSLYSDQTSYLSICLEE 639
+KI L+ +LE + + LRK+ + Q+ + R+ + + + QT+ ++I L
Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA 630
Query: 640 NNRFQV---------------------------EHFSQEELKKKVSDLIQLVKELYTDNQ 672
++ V E + K++ ++ + K+ +N+
Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 673 -----HLKKTIFDLSCMGFQGNGFPDRLA-STEQTELLASKEDEDTIKIGEDDEINFLSD 726
L+K ++ + Q +L ++++ E+L + +I E N
Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750
Query: 727 QHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLL-APLFNEKA 785
Q+ +I+ +++ LR K++ + A +E + L L ++
Sbjct: 751 ATTQKQEQIINTMTQD------LRGANEKLAVAE-VRAENLKKEKEMLKLSEVRLSQQRE 803
Query: 786 TLLLESRPDLLKVV----------------RELLLGQLFLTEQEVSGEHLDGKTEKTPKQ 829
+LL E R L + ++ L Q+ E E+S HL K E +Q
Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEIS--HLKKKLENEVEQ 861
Query: 830 KGEL-----VHFVQTNSFSKPHDELKLSCEAQLVKAGE---VPKVGLKDASVQTVATEGD 881
+ L V + T L L+ + L A + K L + VQ VA++
Sbjct: 862 RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQ-VASQSS 920
Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLH--------GVPGWQAALLSLPGITNREA 933
K + + + + ++ E + +L V +QA + SL N+E
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980
Query: 934 KKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993
+ + RL + E TQL+ +++E++ E +E + ++ E
Sbjct: 981 Q-------VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRA------IE 1027
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
++ + KTL + Q V A Q + T S + D +Q ++++
Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRA-------STALSNEQQARRDCQEQAKIAVEAQN 1080
Query: 1054 CPPDDL----ASLPSCKENPEDVLSPTSVATYLSSKSQP--SAKVSVMGTDQSESINTSN 1107
+L A + + + E V SV +L +Q S + + + +
Sbjct: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140
Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167
E + DLE QN + Q + + +V G +G + +S + G E
Sbjct: 1141 EVSKCVCRCEDLEK-----QNRLLHDQIEKLSDKVVASVKEGVQGPLN-VSLSEEGKSQE 1194
Query: 1168 EMT------------------FSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQ 1209
++ + + +RY + V++L E+ DS E K Q+ +
Sbjct: 1195 QILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAK 1254
Query: 1210 EYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQ---------RQQI 1260
+E + + + R+ L Q QA+ L+ ++
Sbjct: 1255 TMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAEL 1314
Query: 1261 KDGHGICVISRQHMNTMIKAFEE-----LLQASDVDYCVAEGFQEQLNQ-------CAEL 1308
+ G+ ++ + +K ++ + Q D D E +++ L++ +L
Sbjct: 1315 SEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPD---TEEYRKLLSEKEVHTKRIQQL 1371
Query: 1309 LEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368
E++ +L + L++ ++ED L E+ + + D + K+
Sbjct: 1372 TEEIGRLKAEIARSNASLTNNQNLIQSLKED-LNKVRTEKETIQKDLDAKIIDIQEKVKT 1430
Query: 1369 FFS--------RDQKQDNETEKTSVMVNSF--SQDLLMEHI--QEIRTLRKRLEESIKTN 1416
+ Q ++ + ++ VM S S D +H+ QE++ L++ L ++ +
Sbjct: 1431 ITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKS 1490
Query: 1417 EKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKE 1476
+ L Q+E + T + E L SE+ LR+ Q + + ++
Sbjct: 1491 KSLESQVENLQKTLSEKETEA-RNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEK 1549
Query: 1477 NDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRV 1536
+K R+++ + HL + +ENE L++ ++ +L +VR + +
Sbjct: 1550 EEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL--DVRITALKSQYE 1607
Query: 1537 QEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
+L ++L ++ L+ + K+ E+ R++
Sbjct: 1608 GRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645
Score = 66.6 bits (161), Expect = 2e-10
Identities = 266/1374 (19%), Positives = 518/1374 (37%), Gaps = 219/1374 (15%)
Query: 537 KTIFSKEKKQSSDYEELIQVLK--------KEQDIYTHLVKSLQESDSINNLQAELNKIF 588
K++ +K +K +D + I LK + + Y + K L S L E +
Sbjct: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE--RLVNETRECQ 76
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
+LR +LE+ N K L E+ E+ ++ + ++ S T
Sbjct: 77 SLRLELEK----LNNQLKALTEKNKELEIAQDRNIAIQSQFTR----------------- 115
Query: 649 SQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE 708
++EEL+ + DLI+ + L + ++L + + L+ + N L Q +L +
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGEL----QLKLDELQA 171
Query: 709 DEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCL 768
+ ++K E + L+Q E++ +N +L +TE K + D A G
Sbjct: 172 SDVSVKYRE---------KRLEQEKELLHS------QNTWL-NTELK-TKTDELLALGRE 214
Query: 769 EEGAFINLLAPLFNEKATLL-LESRPDLLKVVRELLLGQL--FLTEQEVSGEHLDGKTEK 825
+ + L L N+K + LE + + LK E L + LT+ + + E EK
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
Query: 826 TPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRF 885
+ H +N + D+ + +L +A E LK+A A + LL
Sbjct: 275 FHNELN--AHIKLSNLYKSAADDSEAKSN-ELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
Query: 886 KHEATREAWEEKPINTALSAEHRPEN---LHGVPGWQAALLSLPGITNREAKKSRLPILI 942
E +++ E++ + E EN L + A+LS + + + ++
Sbjct: 332 --EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389
Query: 943 KPSRSLGNMYRLPAT-------------------QEVVTQLQSQILELQGELKEFKTCNK 983
KP L +Y E+V +++++ L+ + +E++ K
Sbjct: 390 KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQK 449
Query: 984 QLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ 1043
+ + E M+ + A +D+ + +K S R M+ ++
Sbjct: 450 AVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
Query: 1044 QRSYEI--DSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSE 1101
R + D E+ D +S +V+S V+ + Q + ++ +
Sbjct: 510 ARGNHVIRDEEVSSADISSS--------SEVISQHLVSYRNIEELQQQNQRLLVALRELG 561
Query: 1102 SINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIIT-----------VLCGT 1150
E E KI +L+ +LE + QL+K Q ++ +L T
Sbjct: 562 ETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQT 621
Query: 1151 EGAQDGL-----------SKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVL 1199
G L S PK S + T S+ V ++ + + A +
Sbjct: 622 TGVAIPLHASSLDDVSLASTPKRPSTSQ--TVSTPAPVPVIESTEAIEAKAALKQLQEIF 679
Query: 1200 ENLKQQLEEQEYKLQKEQNLNMQ-LFSEIHNLQNKFR---DLSPPRYDSL---VQSQARE 1252
EN K++ E E K+Q EQ +Q +++ + K D + RY+ L V+ RE
Sbjct: 680 ENYKKEKAENE-KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738
Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312
++ ++ + Q +NTM + L+ ++ VAE E L + E+L+
Sbjct: 739 ITSLHERNQKLTATTQKQEQIINTMTQD----LRGANEKLAVAEVRAENLKKEKEMLKLS 794
Query: 1313 E-KLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFS 1371
E +L +S+ E QN L+ ++ T Q +L S ET K
Sbjct: 795 EVRLSQQRESLLAEQRGQNLLLTNLQ----TIQGILERS------------ETETK---- 834
Query: 1372 RDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQ---GS 1428
Q+ ++ EK +EH EI L+K+LE ++ L + L+ Q
Sbjct: 835 --QRLSSQIEK-------------LEH--EISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877
Query: 1429 EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM----------------------L 1466
+ T++ + EL + EI L++ + L
Sbjct: 878 RQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDL 937
Query: 1467 IKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE-NERLQ-------------KEG 1512
+ R +++ + L+E L T ++E Q S++E N+ Q KE
Sbjct: 938 VSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKES 997
Query: 1513 SEKERHNQQLIQEVRCSGQEL-SRVQEEVKLRQQLLSQNDKLLQSLRVEL-----KAYEK 1566
+E + ++ + EV QEL + ++ +Q LS+ K L S++ E+ +A
Sbjct: 998 AEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTA 1057
Query: 1567 LDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATS 1626
L E + RD + + + + ++ + V + S T+
Sbjct: 1058 LSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETT 1117
Query: 1627 TPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQE 1686
S+L+ W + R + + + + + RLL + + + ++ +E
Sbjct: 1118 QKAESQLLECKASWEERE-RMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE 1176
Query: 1687 LGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEV 1746
G +GP LS+ S L R ++ + + +++ ++ E+
Sbjct: 1177 -GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLEREL 1235
Query: 1747 TKLHKKLFEQEKKLQNTMKLL----QLSKRQEKVIFDQLVVTHKILRKARGNLE 1796
+L L + +K+Q T K + +L K+ E + + ++ T+K+LR+ + LE
Sbjct: 1236 QELQDSLNAEREKVQVTAKTMAQHEELMKKTETM--NVVMETNKMLREEKERLE 1287
Score = 60.5 bits (145), Expect = 1e-08
Identities = 88/423 (20%), Positives = 188/423 (44%), Gaps = 35/423 (8%)
Query: 46 NVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEE--RMQQEFHGPTEHIYKTN 103
N E V T A+ M E + + + N ++ EE R++Q+ + K
Sbjct: 1243 NAEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE 1301
Query: 104 IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDAR-------KKVQQV 156
+++ + ++ EL E+ +L K +E + + Q + + +K+
Sbjct: 1302 LDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE 1360
Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM---KKMHEGDLAMA 213
+++ TKRI L +++ +AE+ ++ A + L L+ L+++ K+ + DL
Sbjct: 1361 KEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK 1420
Query: 214 LV-LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER 272
++ + EK + I ++K + + + LK ++ ++ SSG+ + + +E +E
Sbjct: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ-SSGDHQEQHVSVQEMQEL 1479
Query: 273 ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEK 332
+ Q E + + S E +++ L++ L EKE E ++ +++ + L L+ +
Sbjct: 1480 KETLNQAETKSK--SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
+ E+L +I + KA A K++ G +D T KE R+ L +
Sbjct: 1538 QEEQLRQQITEKEEKTRKAIVA-AKSKIAHLAGVKDQLT----KENEELKQRNGALDQQK 1592
Query: 393 ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE 452
+ +R IT S + RLE++L E H+E+ + R+E ++ N+V E
Sbjct: 1593 DELDVR-----ITALKSQYEGRISRLERELRE-HQERH------LEQRDEPQEPSNKVPE 1640
Query: 453 REK 455
+++
Sbjct: 1641 QQR 1643
Score = 59.7 bits (143), Expect = 3e-08
Identities = 232/1269 (18%), Positives = 477/1269 (37%), Gaps = 177/1269 (13%)
Query: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
EK + + SEI+ L K R K ++++ + + S + ++ Q+L
Sbjct: 26 EKFLADQQSEIDGL-----KGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRL 80
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
E +L +K +T++ +L+ ++R + R K + + RDL E+L E+
Sbjct: 81 ELE--KLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQEL 138
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYL 510
L+E K+L+ + L ES K L K +E L
Sbjct: 139 ------------EYLTEDVKRLNEK------LKESNTTKGELQLKLDE-----------L 169
Query: 511 MAAE-DLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVK 569
A++ ++ R + L EK + T + E K +D EL+ + +++ + L
Sbjct: 170 QASDVSVKYREKRLEQEK---ELLHSQNTWLNTELKTKTD--ELLALGREKGNEILELK- 223
Query: 570 SLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQ 629
NL+ + ++ L +Q+ S ++L+K +E+ +++++ +E+ S+
Sbjct: 224 --------CNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
Query: 630 TSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGN 689
+ L+ ++ +N ++ + ++ + K ++L + V+EL+ + LK+ G
Sbjct: 276 HNELNAHIKLSNLYK---SAADDSEAKSNELTRAVEELH---KLLKEA-------GEANK 322
Query: 690 GFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYL 749
D L EQ++ E E KIG ++ L+ +N+++ + K L
Sbjct: 323 AIQDHLLEVEQSK--DQMEKEMLEKIGR-------LEKELENANDLLSATKR---KGAIL 370
Query: 750 RHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFL 809
E A ++ G + L + E LL + + ++ + L +
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL---DEIV 427
Query: 810 TEQEVSGEHLDGKTEKTPK-QKGELVHFVQTNSFSKPHDELKLSCE------AQLVKAGE 862
E E L + E+ + QK V+ K L+ + + L +
Sbjct: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNR 487
Query: 863 VPKVGLKDAS--VQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQA 920
++ +KD S ++ + E + R H +E+ + +S+ + H
Sbjct: 488 RMEIQVKDLSQQIRVLLMELEEARGNHVIR----DEEVSSADISSSSEVISQH------- 536
Query: 921 ALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKT 980
L+S I + + RL + ++ T +T+LQ L+L+ L E +
Sbjct: 537 -LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQ---LKLESALTELEQ 592
Query: 981 CNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMD 1040
K ++ L ++++ R D + G A P + S K
Sbjct: 593 LRKSRQHQMQLVDSIVRQR---DMYRILLSQTTGVAI---PLHASSLDDVSLASTPKRPS 646
Query: 1041 SDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS--AKVSVMGTD 1098
+ Q S + + + + +++ + K Q K+ TD
Sbjct: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD 706
Query: 1099 -QSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQ--------CSEAIITVLCG 1149
+S++ S + ++ ++ L+ +EGY+ I L + +Q + I T+
Sbjct: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD 766
Query: 1150 TEGAQDGLSKPKNGSDG--EEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLE 1207
GA + L+ + ++ +E L +VR + + L LA + + +L NL+
Sbjct: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESL--LAEQRGQNLLLTNLQ---T 821
Query: 1208 EQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGIC 1267
Q + E +L S+I L+++ L + + Q +L Q + +
Sbjct: 822 IQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLD 881
Query: 1268 VISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMN 1327
+ H+NT +ELL+ + + A L + L + + S +
Sbjct: 882 TETNLHLNT-----KELLKNAQ-------------KEIATLKQHLSNMEVQVASQSSQRT 923
Query: 1328 TQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMV 1387
+ + + + D+L Q L E R + + E+ MV
Sbjct: 924 GKGQPSNKEDVDDLVSQ--------------LRQTEEQVNDLKERLKTSTSNVEQYQAMV 969
Query: 1388 NSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSS 1447
S + L E Q +RK +E +K + + + QLE++ E + EL
Sbjct: 970 TSLEESLNKEK-QVTEEVRKNIEVRLKESAEFQTQLEKKLME-------VEKEKQELQDD 1021
Query: 1448 LTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER 1507
I + +Q L L ++++E+L R + +L + Q+ +E+ +
Sbjct: 1022 KRRAIESMEQQLSELKKTL-------SSVQNEVQEALQRASTALSNEQQARRDCQEQAKI 1074
Query: 1508 LQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKL 1567
+ ++ ER +V +V + +RQ L K +S +E KA
Sbjct: 1075 AVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQK-AESQLLECKA--SW 1131
Query: 1568 DEEHRRLRD 1576
+E R L+D
Sbjct: 1132 EERERMLKD 1140
Score = 50.8 bits (120), Expect = 1e-05
Identities = 137/748 (18%), Positives = 301/748 (40%), Gaps = 105/748 (14%)
Query: 1058 DLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIH 1117
++A+L N E + S ++ + K QPS K D + ++ +TE ++++
Sbjct: 900 EIATLKQHLSNME--VQVASQSSQRTGKGQPSNK-----EDVDDLVSQLRQTE---EQVN 949
Query: 1118 DLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQV 1177
DL+ L+ + + Q Q A++T L ++ L+K K ++ +V
Sbjct: 950 DLKERLKTSTSNVEQYQ-------AMVTSL------EESLNKEKQVTEEVRKNI----EV 992
Query: 1178 RYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL--QKEQNLNMQLFSEIHNLQNKFR 1235
R + + L ++++ +E KQ+L++ + + EQ L+ +L + ++QN+ +
Sbjct: 993 RLKESAEFQTQLEKKLME---VEKEKQELQDDKRRAIESMEQQLS-ELKKTLSSVQNEVQ 1048
Query: 1236 DLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVA 1295
+ +Q + LS ++Q +D I+ + N + E +L A+DV+
Sbjct: 1049 EA--------LQRASTALSNEQQARRDCQEQAKIAVEAQNKYER--ELMLHAADVE--AL 1096
Query: 1296 EGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355
+ +EQ+++ A + + LE+ +S +E E ER+ +D ++ E E
Sbjct: 1097 QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQN 1156
Query: 1356 SHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLE----- 1410
E + ++ S+ SQ+ ++E ++ IR ++ E
Sbjct: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEV 1216
Query: 1411 ---ESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLI 1467
ES++ +++ + LER+ E +Q S + ++ + ++ L K+ + +N ++
Sbjct: 1217 AQVESLRYRQRV-ELLERELQE-LQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVM- 1273
Query: 1468 KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVR 1527
+ ++ ++E ++L + L + + L+ + ++E N L ++ + + L ++V+
Sbjct: 1274 ETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVK 1333
Query: 1528 ---CSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLR-DGDKYPME 1583
Q L Q++ + KLL V K ++L EE RL+ + +
Sbjct: 1334 RWKARNQHLVSQQKDPDTEEYR-----KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNAS 1388
Query: 1584 SDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASK 1643
N+ +L S + K +E + D D+ D + V ++
Sbjct: 1389 LTNNQNLIQSLKEDLNKVRTEKETIQ-KDLDAKIIDIQEKVKTITQVKKI---------- 1437
Query: 1644 NGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSS 1703
GR E+ +A ++ ++T S QE L + ++
Sbjct: 1438 -GRRYKTQYEELKAQQDKV-----------METSAQSSGDHQEQHVSVQEMQELKETLNQ 1485
Query: 1704 VSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNT 1763
T +LE L+ + + E + E L ++ + + +L
Sbjct: 1486 AETKSKSLESQVENLQ-----------------KTLSEKETEARNLQEQTVQLQSELSRL 1528
Query: 1764 MKLLQLSKRQEKVIFDQLVVTHKILRKA 1791
+ LQ QE+ + Q+ + RKA
Sbjct: 1529 RQDLQDRTTQEEQLRQQITEKEEKTRKA 1556
Score = 45.4 bits (106), Expect = 5e-04
Identities = 65/283 (22%), Positives = 125/283 (44%), Gaps = 42/283 (14%)
Query: 411 LQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNK 470
LQQ ER E + + ++K + + D ++E++ L+ + + E +Y E K
Sbjct: 5 LQQVLERTELN-KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQY----FEIEK 59
Query: 471 KL-HNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCS 529
+L H+QE+++ E + + + L+K N + + ++N L A+D + + T +
Sbjct: 60 RLSHSQERLVNETRECQSLR-LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT-RTK 117
Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA 589
+ + + ++ S + E L + +K+ L + L+ES N + EL
Sbjct: 118 EELEAEKRDLIRTNERLSQELEYLTEDVKR-------LNEKLKES---NTTKGEL----- 162
Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQT-----------SYLSICLE 638
QL+ D L ++ E +R E+E L+S T L++ E
Sbjct: 163 ---QLKLDELQASDVSVKYRE-----KRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 639 ENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
+ N + E K++VS L + + L T N+HL+K + DL
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL 257
Score = 45.1 bits (105), Expect = 6e-04
Identities = 91/443 (20%), Positives = 161/443 (36%), Gaps = 95/443 (21%)
Query: 1347 LPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVN---SFSQDLLMEHIQEIR 1403
LP+S + L+D ++ R +K E+E+ + S SQ+ L+ +E +
Sbjct: 17 LPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQ 76
Query: 1404 TLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN 1463
+LR LE K N +L+ E+ E+ + +N A+
Sbjct: 77 SLRLELE---KLNNQLKALTEKN-----------------------KELEIAQDRNIAIQ 110
Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLI 1523
+ + + + E L + R + LE+L + VK NE+L++ + K
Sbjct: 111 SQFTRTKEELEAEKRDLIRTNERLSQELEYLTED---VKRLNEKLKESNTTKG------- 160
Query: 1524 QEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQS----LRVELKAYEKLDEEHRRLRDGDK 1579
E++ EL VK R++ L Q +LL S L ELK K DE R+
Sbjct: 161 -ELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT--KTDELLALGRE--- 214
Query: 1580 YPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHL 1639
GN+ L C+ + + + G
Sbjct: 215 -----------------------------KGNEILELKCNLENKKEEVSRLEEQMNG--- 242
Query: 1640 WASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSK 1699
+ H+ +ED LK+ + Q + E A S L K
Sbjct: 243 -LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSN-----------LYK 290
Query: 1700 FVSSVSTAKLT-LEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTK-LHKKLFEQE 1757
+ S AK L A L L + + + H ++ + K ++ K + +K+ E
Sbjct: 291 SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLE 350
Query: 1758 KKLQNTMKLLQLSKRQEKVIFDQ 1780
K+L+N LL +KR+ ++ ++
Sbjct: 351 KELENANDLLSATKRKGAILSEE 373
Score = 42.0 bits (97), Expect = 0.005
Identities = 77/371 (20%), Positives = 150/371 (40%), Gaps = 57/371 (15%)
Query: 1268 VISRQHMNTMIKAFEELL------QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321
V+ R +N + K+ + L Q S++D + ++ + E ++L + +
Sbjct: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+ E L +E+ N + L ++ E + D + +S F+R K++ E E
Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQ---DRNIAIQSQFTRT-KEELEAE 123
Query: 1382 KTSVMVNSFSQDLLMEHIQE-IRTLRKRLEESIKTNEKLRKQL-ERQGSEFVQGSTSIFA 1439
K ++ + +E++ E ++ L ++L+ES T +L+ +L E Q S+
Sbjct: 124 KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASD---------V 174
Query: 1440 SGSELHSSLTSEIHFLRKQNQALNAML-------IKGSRDKQKENDKLRESLSRKTVSLE 1492
S L E L QN LN L + R+K E +L+ +L K +
Sbjct: 175 SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVS 234
Query: 1493 HLQREYASVKEENERLQK---------------EGSEKERHNQQLIQEVRCS-------- 1529
L+ + +K NE LQK + S +E+ + +L ++ S
Sbjct: 235 RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAAD 294
Query: 1530 -----GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMES 1584
EL+R EE+ + + +K +Q +E++ K E L + E
Sbjct: 295 DSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVE-QSKDQMEKEMLEKIGRLEKEL 353
Query: 1585 DNSFDLFDSSQ 1595
+N+ DL +++
Sbjct: 354 ENANDLLSATK 364
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 98.6 bits (244), Expect = 5e-20
Identities = 137/611 (22%), Positives = 261/611 (42%), Gaps = 71/611 (11%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
EE V+ A + E++ TELKK+ +LKL + E+ Q TE+ K E
Sbjct: 978 EEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQ-----ATENKVKNLTEEMA 1032
Query: 109 EVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL--LTKRILL 166
++ L + ++ L +A + +A + + + + QQVEDL ++
Sbjct: 1033 ALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKK 1092
Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI--- 223
L D A+ +LE T+ A + + +L E K + +L+ + E ++L+
Sbjct: 1093 LRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQ 1152
Query: 224 ------------EELKLSLKSKEALIQCLKEEKSQMACPDENVSS--GELRGLCAAPREE 269
EEL+ L+++ A +++++++ A E +S E G A RE
Sbjct: 1153 MQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREG 1212
Query: 270 -KERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328
++RE E ++ + E + R +A LR K+ E A E + + L +
Sbjct: 1213 CRKREAELGRLRRELEEAAL--RHEATVAALRRKQAEGAAE------LGEQVDSLQRVRQ 1264
Query: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
EK+ EL E++ L+A E L +A+ + YE LS + L+ Q
Sbjct: 1265 KLEKEKSELRMEVDDLAANV----ETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 389 TKSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDC 434
ST+ RL+ ++++ L + + Q E L + LEE + KS
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 435 TIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN-----QEQVIKHLTESTNQK 489
++ LR++ + LR E +E E + + LLS++N ++ + I+ E K
Sbjct: 1381 AVQALRHDCDLLR-EQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAK 1439
Query: 490 DVLLQKFNEKD--LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
L + E + +E C + L L++E +E + + + + +KKQ
Sbjct: 1440 KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE---SEDVTLELERATSAAAALDKKQR 1496
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR-- 605
L + ++E+++ L + +ES + ++F LR E+ + + + L+
Sbjct: 1497 HLERALEERRRQEEEMQRELEAAQRESRGLG------TELFRLRHGHEEALEALETLKRE 1550
Query: 606 -KTLEEQISEI 615
K L+E+IS++
Sbjct: 1551 NKNLQEEISDL 1561
Score = 87.4 bits (215), Expect = 1e-16
Identities = 157/690 (22%), Positives = 290/690 (42%), Gaps = 96/690 (13%)
Query: 43 LLPNVSEETVSPTRARNM-KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK 101
L NV T + A + + +E+Q++E K + +EE +Q T+
Sbjct: 1280 LAANVETLTRAKASAEKLCRTYEDQLSEAKIK----------VEELQRQLADASTQRG-- 1327
Query: 102 TNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKK----VQQVE 157
L+ E L R L+E+E L+ + S+ ++LA E++R E+ K V+
Sbjct: 1328 ---RLQTESGELSRLLEEKECLISQLSRG-KALAAQSLEELRRQLEEESKAKSALAHAVQ 1383
Query: 158 DLLTKRILLLEK--DVTAAQAELEKAFAGTETEKAL-RLRLESK-LSEMKKMHEGDLAMA 213
L LL E+ + AQAEL++ + E A R + E+ + +++ E +A
Sbjct: 1384 ALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA 1443
Query: 214 LVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGEL----------RGLC 263
L L E + +E S E L+ E + E +S R L
Sbjct: 1444 LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE 1503
Query: 264 AAPREEKE--RETEAAQMEHQ-------KERNSFEERIQALEEDLREK---EREIATEKK 311
R+E+E RE EAAQ E + + R+ EE ++ALE RE + EI+
Sbjct: 1504 ERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD 1563
Query: 312 NSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYET 371
K+IQ L K+ E + E+ + +E+ A + Q + Q + +
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623
Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEE------- 424
L+ K+ A LR +N ++ E+ L+ S+ T+ ++ + ++++E DL +
Sbjct: 1624 KLAEKDEECANLR-RNHQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGH 1680
Query: 425 AHREKSKGDCTIRDL----------RNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN 474
A R+ ++ R + R+E ++L E++E+ +A+E R L +E +
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAA 1740
Query: 475 QEQ-------VIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
EQ + L E+T + ++L + ++ ++ Q L A DL S G + E
Sbjct: 1741 LEQGERSRRLAEQELLEATERLNLL----HSQNTGLLNQKKKLEA--DLAQLS-GEVEEA 1793
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE-SDSINNLQAELNK 586
++ K KK +D + + LKKEQD HL + + ++ LQA L
Sbjct: 1794 AQERREAEEKA-----KKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLE- 1847
Query: 587 IFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVE 646
E + + + +K +++ +++R E E + L + R +
Sbjct: 1848 --------EAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKEL 1899
Query: 647 HFSQEELKKKVSDLIQLVKELYTDNQHLKK 676
+ EE +K ++ + LV +L + + K+
Sbjct: 1900 AYQAEEDRKNLARMQDLVDKLQSKVKSYKR 1929
Score = 75.5 bits (184), Expect = 4e-13
Identities = 142/637 (22%), Positives = 262/637 (41%), Gaps = 89/637 (13%)
Query: 69 ELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE--------- 119
+++K+ L+ R LEE ++ E + K E E+E L L+E
Sbjct: 1152 QMQKKIKELQARAEELEEELEAE-RAARARVEKQRAEAARELEELSERLEEAGGASAGQR 1210
Query: 120 -----REQLLIKASKAVESLA---EAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDV 171
RE L + + +E A EA + ++R + + ++ + D L + LEK+
Sbjct: 1211 EGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEK 1270
Query: 172 TAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALV-LDEKDRLIEELKLS- 229
+ + E++ A ET R ++ ++ + +E L+ A + ++E R + +
Sbjct: 1271 SELRMEVDDLAANVET----LTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQR 1326
Query: 230 --LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS 287
L+++ + L EEK C +S G + L A EE R+ E E K +++
Sbjct: 1327 GRLQTESGELSRLLEEKE---CLISQLSRG--KALAAQSLEELRRQLE----EESKAKSA 1377
Query: 288 FEERIQALEED---LREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKL 344
+QAL D LRE+ E A E + L+R L +V + S+ E
Sbjct: 1378 LAHAVQALRHDCDLLREQHEEEA-EAQAELQR---------LLSKANAEVAQWRSKYE-- 1425
Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKI 404
A + E L++A+ + ++ E + A ++L L TE+ + +++
Sbjct: 1426 -ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERA 1484
Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGDCTI-------RDLRNEVEKLRNEVNEREKAM 457
T + L +++ LE+ LEE R++ + + R L E+ +LR+ E +A+
Sbjct: 1485 TSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL 1544
Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLE 517
E L NK N ++ I LT+ + +Q+ + + + + AA +
Sbjct: 1545 ET-----LKRENK---NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596
Query: 518 LRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI 577
+ L K Q S+ ++K + EE + + Q V+SLQ S
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ----RAVESLQAS--- 1649
Query: 578 NNLQAEL---NKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFS---LYSDQTS 631
L AE N+ L+K++E D+ LE Q+ R+ E+ + L Q
Sbjct: 1650 --LDAETRARNEALRLKKKMEGDL-------NDLELQLGHATRQATEAQAATRLMQAQLK 1700
Query: 632 YLSICLEENNRFQVE-HFSQEELKKKVSDLIQLVKEL 667
+E R E H + L+++ S L ++EL
Sbjct: 1701 EEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737
Score = 75.1 bits (183), Expect = 6e-13
Identities = 124/565 (21%), Positives = 245/565 (43%), Gaps = 72/565 (12%)
Query: 226 LKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGL--CAAPREEKERETEAAQMEHQK 283
+KL K K L EE+ ELRGL A E K +E E + +
Sbjct: 879 MKLFFKMKPLLRSAQAEEELAAL-------RAELRGLRGALAAAEAKRQELEETHVSITQ 931
Query: 284 ERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEK 343
E+N ++QA +++L + E E+ + L + K + L+ K K++ E + E+
Sbjct: 932 EKNDLALQLQAEQDNLADAE-----ERCHLLIKSK------VQLEGKVKELSERLEDEEE 980
Query: 344 LSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403
++A A R L+ T+ + +D + L+ E A ++ + E L S+ +
Sbjct: 981 VNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR 1040
Query: 404 ITQELSDLQQERERLEKDLE-EAHREKSKGDCTIRDLRNEVEKLRNEVNEREK-AMENRY 461
+T+E LQ+ ++ DL+ E R + +R L +VE L + + +K M+
Sbjct: 1041 LTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLR-LEQQVEDLECSLEQEKKLRMDTER 1099
Query: 462 KSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ-----QNCYLMAAE-- 514
E + KL QE V ++ K L +K +KD E+ Q ++ L+ A+
Sbjct: 1100 AKRKLEGDLKL-TQESV----ADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQ 1154
Query: 515 ----DLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKS 570
+L+ R+E L E+ +++ ++ + + + + + EEL + L++ +
Sbjct: 1155 KKIKELQARAEEL-EEELEAERAARAR-VEKQRAEAARELEELSERLEEAGGASAGQREG 1212
Query: 571 LQESDS-INNLQAELNK--------IFALRK-------QLEQDVLSYQNLRKTLEEQISE 614
++ ++ + L+ EL + + ALR+ +L + V S Q +R+ LE++ SE
Sbjct: 1213 CRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSE 1272
Query: 615 IRRREEESF----SLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTD 670
+R ++ +L + S +C ++ EEL+++++D L T+
Sbjct: 1273 LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE 1332
Query: 671 NQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEI-------NF 723
+ L + + + C+ Q + LA+ EL E+E K + +
Sbjct: 1333 SGELSRLLEEKECLISQLSR-GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 724 LSDQHLQQSN---EIMKDLSKGGCK 745
L +QH +++ E+ + LSK +
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAE 1416
Score = 51.2 bits (121), Expect = 9e-06
Identities = 77/325 (23%), Positives = 150/325 (46%), Gaps = 24/325 (7%)
Query: 62 DFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE 121
+ + ++ E +E NL+ E +Q T + + LK ++E +L+
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA-LRLKKKMEGDLNDLEL-- 1676
Query: 122 QLLIKASKAVESLAEAGGSEIQRVKEDA-RKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
QL +A E+ A + Q +E A R + Q++ L ++ LE+ + AELE+
Sbjct: 1677 QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEE 1736
Query: 181 AFAGTET-EKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL-KLSLKSKEALIQ 238
A E E++ RL + L ++++ +L++K +L +L +LS + +EA +
Sbjct: 1737 LRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQE 1796
Query: 239 CLK-EEKSQMACPDENVSSGELRGL--CAAPREEKERETEAAQMEHQKERNSFEE----- 290
+ EEK++ A D + + EL+ +A E ++ E E Q E+
Sbjct: 1797 RREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG 1856
Query: 291 ---RIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAA 347
++Q LE +RE E E+ E+K K +A++G ++ E++V+EL + E+
Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQK---KHAEALKG----VRKHERRVKELAYQAEEDRKN 1909
Query: 348 FAKAREALQKAQTQEFQGSEDYETA 372
A+ ++ + K Q++ +E A
Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEEA 1934
Score = 50.1 bits (118), Expect = 2e-05
Identities = 68/324 (20%), Positives = 126/324 (38%), Gaps = 40/324 (12%)
Query: 55 TRARN------------MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT 102
TRARN + D E Q+ ++ + ++ ++++E G E
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ--- 1710
Query: 103 NIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK 162
L E+ + L+ R LL + + + E G E +R+ +Q T+
Sbjct: 1711 --RLAAELHEQAQALERRASLLAAELEELRAALEQG--------ERSRRLAEQELLEATE 1760
Query: 163 RILLLEKDVTAA-----QAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLD 217
R+ LL T + E + A E E+A + R E++ K + + + +
Sbjct: 1761 RLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK 1820
Query: 218 EKDRL--IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE 275
E+D +E +K +L+ +Q EE Q A +L E K RE E
Sbjct: 1821 EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKL--------EAKVRELE 1872
Query: 276 AAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVE 335
A QK+ + ++ E ++E + ++KN + + L +KS +++ E
Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE 1932
Query: 336 ELNSEIEKLSAAFAKAREALQKAQ 359
E + A + KA+ L A+
Sbjct: 1933 EAEQQANTNLAKYRKAQHELDDAE 1956
Score = 46.2 bits (108), Expect = 3e-04
Identities = 101/478 (21%), Positives = 168/478 (35%), Gaps = 80/478 (16%)
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELE-GYQNFIFQLQKHSQCS 1140
+ SK Q KV + + + + ++K+ D TEL+ + L K +
Sbjct: 958 IKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEK 1017
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
+A TE L++ D + + H + LG L E L
Sbjct: 1018 QA-------TENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070
Query: 1201 N----LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQ 1256
L+QQ+E+ E L++E+ L M L+ + L Q + +
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK---------LTQESVADAAQD 1121
Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLF 1316
+QQ+++ + K EL Q S EQL A++ +K+++L
Sbjct: 1122 KQQLEE-------------KLKKKDSELSQLS------LRVEDEQLLG-AQMQKKIKELQ 1161
Query: 1317 LNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376
+ + E+ + R+E+ L E E E S Q++
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSE----------RLEEAGGASAGQRE 1211
Query: 1377 DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS 1436
+ E+ LR+ LEE+ +E L R+ +E
Sbjct: 1212 GCRKREA-----------------ELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254
Query: 1437 IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLR---ESLSRKTVSLEH 1493
S + L E LR + L A + +R K R + LS + +E
Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314
Query: 1494 LQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSR-----VQEEVKLRQQL 1546
LQR+ A + RLQ E E R L++E C +LSR Q +LR+QL
Sbjct: 1315 LQRQLADASTQRGRLQTESGELSR----LLEEKECLISQLSRGKALAAQSLEELRRQL 1368
Score = 43.9 bits (102), Expect = 0.001
Identities = 85/422 (20%), Positives = 161/422 (38%), Gaps = 51/422 (12%)
Query: 1379 ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE---RQGSEFVQGST 1435
E E+T V + DL ++ E L EE K + QLE ++ SE ++
Sbjct: 921 ELEETHVSITQEKNDLALQLQAEQDNLADA-EERCHLLIKSKVQLEGKVKELSERLEDEE 979
Query: 1436 SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQ 1495
+ A + L E L+K L L K ++KQ +K++ +L
Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVK-----------NLT 1028
Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
E A++ E RL KE + +QQ + +++ E RV K + +L Q + L
Sbjct: 1029 EEMAALDESVARLTKEKKALQEAHQQALGDLQA---EEDRVSALTKAKLRLEQQVEDLEC 1085
Query: 1556 SLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDS 1615
SL E+ ++LR M+++ + + +T +SV++ + D
Sbjct: 1086 SL-----------EQEKKLR------MDTERAKRKLEGDLKLTQESVAD----AAQDKQQ 1124
Query: 1616 LSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQ 1675
L + +S V L ++ + + L E L +++ + A ++ Q
Sbjct: 1125 LEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQ 1184
Query: 1676 TQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL-LWRVSLPEDGQCPL 1734
EA + LS+ + A E R+ + L R+ +
Sbjct: 1185 RAEAARELEE-----------LSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALR 1233
Query: 1735 HCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGN 1794
H + ++ + + +L EQ LQ + L+ K + ++ D L + L +A+ +
Sbjct: 1234 HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKAS 1293
Query: 1795 LE 1796
E
Sbjct: 1294 AE 1295
Score = 41.6 bits (96), Expect = 0.007
Identities = 178/889 (20%), Positives = 327/889 (36%), Gaps = 106/889 (11%)
Query: 953 RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKT------- 1005
RL +EV L ++ +L+ E E K L KL LA+A E + T +K
Sbjct: 974 RLEDEEEVNADLAARRRKLEDECTELKKDIDDL--KLTLAKAEKEKQATENKVKNLTEEM 1031
Query: 1006 ---------LLNAQPPVGAAYQDSPGEQKGIKTTSSVW-----------RDKEMDSDQQR 1045
L + + A+Q + G+ + + S D E +Q++
Sbjct: 1032 AALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEK 1091
Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTS-VATYLSSKSQPSAKVSVMGTD-QSESI 1103
+D+E L +E+ D + L K +++S+ D Q
Sbjct: 1092 KLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA 1151
Query: 1104 NTSNETEYLKQKIHDLETELEGYQNFIFQLQKH--------SQCSEAIITVLCGTEGAQD 1155
+ + L+ + +LE ELE + +++K + SE + + G ++
Sbjct: 1152 QMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQRE 1211
Query: 1156 GLSKPKN--GSDGEEMTFSSLHQVRYV-----KHVKILGPLAPEMIDSRVLENLKQQLEE 1208
G K + G E+ ++L V K + L E +DS L+ ++Q+LE+
Sbjct: 1212 GCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELG-EQVDS--LQRVRQKLEK 1268
Query: 1209 QEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ--QIKDGHGI 1266
++ +L+ E + + + L D L +++ + LQRQ G
Sbjct: 1269 EKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGR 1328
Query: 1267 CVISRQHMNTMIKAFEELL-QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVE 1325
++ +++ E L+ Q S A+ +E Q E + L +++ +
Sbjct: 1329 LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHD 1388
Query: 1326 MNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385
+ E E E Q LL ++ A S YE R ++ + +K ++
Sbjct: 1389 CDLLREQHEEEAEAQAELQRLLSKANAEVAQWR-SKYEADA---IQRTEELEEAKKKLAL 1444
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF-VQGSTSIFASGSEL 1444
+ E ++ LE++ KLR Q E + ++ +TS A+ +
Sbjct: 1445 RLQEAE-----EGVEAANAKCSSLEKA-----KLRLQTESEDVTLELERATSAAAALDKK 1494
Query: 1445 HSSLTSEIHFLRKQNQALNAMLIKGSRDKQ---KENDKLRESLSRKTVSLEHLQREYASV 1501
L + R+Q + + L R+ + E +LR +LE L+RE ++
Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554
Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL 1561
+EE L + S + Q+L + + E S +Q ++ + L + +++EL
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLEL 1614
Query: 1562 ---------KAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSG-- 1610
K EK DEE LR + +ES + D+ +++ + G
Sbjct: 1615 SQVKAEVDRKLAEK-DEECANLRRNHQRAVESLQA--SLDAETRARNEALRLKKKMEGDL 1671
Query: 1611 NDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLA 1670
ND + + AT +RL+ L + GR + QRL A
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQA-QLKEEQAGR----------------DEEQRLAA 1714
Query: 1671 EMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDG 1730
E+ Q Q S A L + S A+ L EA RL LL +
Sbjct: 1715 ELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLN 1774
Query: 1731 QCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQN-----TMKLLQLSKRQE 1774
Q + ++ EV + ++ E E+K + M +L K Q+
Sbjct: 1775 QKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQD 1823
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 98.2 bits (243), Expect = 6e-20
Identities = 146/647 (22%), Positives = 267/647 (41%), Gaps = 101/647 (15%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123
EN++TE++ L L+E++Q E EL E E L+ L ++Q
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAE------------TELCAEAEELRARLTAKKQE 912
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183
L + +E+ E Q ++ + +K Q +++L + LE++ +A Q
Sbjct: 913 LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ----LEEEESARQ-------- 960
Query: 184 GTETEKALRLRLESKLSE--MKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL- 240
+L+LE +E +KK+ E + + D+ +L +E KL L
Sbjct: 961 --------KLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 241 -KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDL 299
+EEKS+ +N + L EE+ R E + E +K R E L + +
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDL-----EERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 300 REKEREIATEKKNSLKRDKAIQGLTMALKSKE-------KKVEELNSEIEKLSAAFAKAR 352
E + +IA K K+++ +Q ++ + KK+ EL S+I +L R
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 353 EALQKAQTQEFQGSEDYETALSGKE------ALSAALRSQ-----NLTKSTENHRLRRSI 401
+ KA+ Q+ E+ E + E A LRS+ N+ K T +
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRY 461
+I + Q E L + LE+ R K+ + + L NE +L NEV
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV----------- 1233
Query: 462 KSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSE 521
K LL H +++V L E L KFNE + V + + +EL +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQE-------LQVKFNEGE-RVRTELADKVTKLQVELDNV 1285
Query: 522 GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQ 581
+ + S+ +K FS + Q D +EL+Q +++ L S + ++
Sbjct: 1286 TGLLSQSDSKSSKLTKD-FSALESQLQDTQELLQEENRQK---------LSLSTKLKQVE 1335
Query: 582 AELNKIFALRKQLEQDVLSYQNLRK---TLEEQISEIRRREEESFSLYSDQTSYLSICLE 638
E N + R+QLE++ + NL K TL Q+++++++ E+S +
Sbjct: 1336 DEKN---SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK 1392
Query: 639 E----NNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
+ + R + + + ++L+K + L Q + +L D H +++ +L
Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Score = 79.7 bits (195), Expect = 2e-14
Identities = 121/616 (19%), Positives = 267/616 (43%), Gaps = 68/616 (11%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123
+++ ++L K+ L+ ++ +E +Q+E K +++ E S + +L+E E+
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK-QVEDEKNSFREQLEEEEEA 1351
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183
K + +L A +++++ ED+ ++ E++ K L+KD+ E+ A
Sbjct: 1352 KHNLEKQIATL-HAQVADMKKKMEDSVGCLETAEEVKRK----LQKDLEGLSQRHEEKVA 1406
Query: 184 GTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEE 243
+ + + RL+ +L ++ + A L++K + ++L L EE
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL-------------LAEE 1453
Query: 244 KSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-KERNSFEERIQALEEDLREK 302
K+ +S+ A E +E+ET+A + +E + ++ L + R +
Sbjct: 1454 KT--------ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
++ + K + K++ L + ++ E++VEE+ +++E+L +A + +
Sbjct: 1506 MEDLMSSKDDV---GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562
Query: 363 FQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDL 422
+E L G++ S + Q L R ++++ EL D ER ++ +
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQ----------LVRQVREMEAELED-----ERKQRSM 1607
Query: 423 EEAHREKSKGDCTIRDLRNEVE---KLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
A R+K + D ++DL ++ K R+E ++ + ++ + K + E + ++E+++
Sbjct: 1608 AVAARKKLEMD--LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 480 KHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539
E N+K K + E+IQ L AAE + +++ E K
Sbjct: 1666 AQAKE--NEK-----KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 540 FSKEKKQ--SSDYEELIQVLKKEQD----IYTHLVKSLQESDSINNLQAELNKIFALRKQ 593
+ E+K+ + +L + L++EQ I L K+ + D IN L + A + +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT-DLNLERSHAQKNE 1777
Query: 594 LEQDVLSYQN--LRKTLEEQISEIRRREEESFSLYSDQTSYLSICLE-ENNRFQVEHFSQ 650
+ L QN L+ L+E ++ + + S + + + L L+ E Q
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 651 EELKKKVSDLIQLVKE 666
+KK+ D++ V +
Sbjct: 1838 RRTEKKLKDVLLQVDD 1853
Score = 72.8 bits (177), Expect = 3e-12
Identities = 120/531 (22%), Positives = 215/531 (40%), Gaps = 89/531 (16%)
Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQAL 295
L+Q ++E+ MA +E V E + L A E + E E Q + E+ +E++QA
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVRE-KQLAA---ENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 296 EEDLREKE--REIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKARE 353
E E E R T KK L+ E +VEE + L A K ++
Sbjct: 893 TELCAEAEELRARLTAKKQELEE---------ICHDLEARVEEEEERCQHLQAEKKKMQQ 943
Query: 354 ALQ--KAQTQEFQGSED--------YETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403
+Q + Q +E + + E L E L QN + E L I +
Sbjct: 944 NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003
Query: 404 ITQELSDLQQERERLEK----------DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNER 453
T L++ +++ + L K DLEE R + K + R ++E +++++
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063
Query: 454 EKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAA 513
++ + L + KK + + + E QK++ L+K E + ++ +
Sbjct: 1064 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE------LQ 1117
Query: 514 EDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE 573
EDLE +E+ S +K +KQ D E ++ LK E +
Sbjct: 1118 EDLE-------SERASR----------NKAEKQKRDLGEELEALKTELE----------- 1149
Query: 574 SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
D++++ A+ LR + EQ+V L+KTLEE+ + +E +S L
Sbjct: 1150 -DTLDSTAAQQE----LRSKREQEV---NILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 634 SICLEENNRFQVE-HFSQEELKKKVSDLIQLVKELYT---DNQHLKKTIFDLSCMGFQGN 689
+ LE+ R + +++ L+ + +L VK L D++H +K + + Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV-EAQLQELQVK 1260
Query: 690 GFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS 740
TE LA K + +++ D + L Q +S+++ KD S
Sbjct: 1261 FNEGERVRTE----LADKVTKLQVEL---DNVTGLLSQSDSKSSKLTKDFS 1304
Score = 72.8 bits (177), Expect = 3e-12
Identities = 104/462 (22%), Positives = 195/462 (42%), Gaps = 64/462 (13%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEH-IYKTNIELK 107
+ET + + AR +++ Q EL E N + R + ++ G + H + K+ L+
Sbjct: 1474 KETKALSLARALEEAMEQKAEL--ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167
+VE +K +L+E E L +A E +Q +K + +Q ++ ++ L
Sbjct: 1532 QQVEEMKTQLEELEDEL----QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM--------KKMHEGDLAMALVLDEK 219
+ V +AELE A R +LE L ++ K E + + +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM 279
+ EL + S+E ++ KE + ++ + + + L AA R +++ + E ++
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAAAERAKRQAQQERDEL 1706
Query: 280 EHQ------------KERNSFEERIQALEEDLREKE--REIATE--KKNSLKRDKAIQGL 323
+ +E+ E RI LEE+L E++ E+ + KK +L+ D+ L
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAAL 383
+ +S +K E ++E+ + +E K Q E Y+ +++ EA A L
Sbjct: 1767 NLE-RSHAQKNENARQQLERQN------KELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 384 RSQ--NLTKSTEN--HRLRRSIKKITQELSDLQQER-----------------ERLEKDL 422
Q N TK + ++RR+ KK+ L + ER ++L++ L
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879
Query: 423 EEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL 464
EEA E + + + R L+ E+E + E AM SL
Sbjct: 1880 EEAEEEAQRANASRRKLQRELE----DATETADAMNREVSSL 1917
Score = 72.4 bits (176), Expect = 4e-12
Identities = 103/469 (21%), Positives = 201/469 (42%), Gaps = 88/469 (18%)
Query: 97 EHIYKTNIELKVEVESLKRELQEREQL---LIKASKAVESLAEAGGSEIQRVKEDARKKV 153
+ + KT L+ E++ L +L + Q L K K + L + + E+ +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 154 QQVEDLLTKRILLLE--KDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLA 211
+ + TK + L ++ +AELE+ TE + + SK K +HE + +
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTE--MEDLMSSKDDVGKSVHELEKS 1526
Query: 212 MALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSG---ELRGLCAAPRE 268
+ ++ +EE+K L+ E +Q ++ K ++ + + + +L+G E
Sbjct: 1527 KRAL----EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 269 EKE------RETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQG 322
+K+ RE EA + +K+R+ + LE DL++ E I + KN RD+AI+
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---RDEAIKQ 1639
Query: 323 L------------------------TMALKSKEKKVEELNSEIEKLSAAFAKAREALQKA 358
L K EKK++ + +E+ +L A A A ++A
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 359 QTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE-- 416
Q + + +++ + SGK AL+ E RL I ++ +EL + Q E
Sbjct: 1700 QQERDELADEIANS-SGKGALAL----------EEKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 417 --RLEK------------DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
RL+K +LE +H +K++ + L + ++L+ ++ E E ++++YK
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNEN--ARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQ------------KDVLLQKFNEK 499
+ ++ K+ E+ + + T+ KDVLLQ +E+
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855
Score = 69.7 bits (169), Expect = 2e-11
Identities = 168/804 (20%), Positives = 310/804 (38%), Gaps = 127/804 (15%)
Query: 811 EQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDEL-KLSCEAQLVKAGEVPKVGLK 869
E+E +HL + +K + EL ++ ++ +L K++ EA+L K E ++ L+
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE-EQIILE 984
Query: 870 DASVQTVATEGDLLRFK-HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGI 928
D + + +A E LL + E T EE+ + +L+ + +N H +A + L
Sbjct: 985 DQNCK-LAKEKKLLEDRIAEFTTNLTEEEEKSKSLA---KLKNKH-----EAMITDLEER 1035
Query: 929 TNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQK 988
RE K+ + L K R L + T L QI ELQ ++ E K + ++
Sbjct: 1036 LRREEKQRQE--LEKTRRKL---------EGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084
Query: 989 LILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYE 1048
L A A +E L K I+ S + + D + +R+
Sbjct: 1085 LQAALARVEEEAAQKNMAL-----------------KKIRELESQISELQEDLESERASR 1127
Query: 1049 IDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE 1108
+E D L + K ED L T+ L SK + + +N +
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE-------------QEVNILKK 1174
Query: 1109 TEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEE 1168
T + K H+ + + QKHSQ E + L T+ + L K K + E
Sbjct: 1175 TLEEEAKTHEAQIQE--------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 1169 MTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIH 1228
++ VK+L L + + ++ QL+E + K + + + +L ++
Sbjct: 1227 GELAN--------EVKVL--LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276
Query: 1229 NLQNKFRDLSP--PRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
LQ + +++ + DS ++ S Q++D + ++ + +L Q
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL---QEENRQKLSLSTKLKQ 1333
Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNE--------------- 1331
D F+EQL + E LEK + +M + E
Sbjct: 1334 VEDEK----NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389
Query: 1332 -------LMERIEEDNLTYQHLLPESP--EPSASHALSDYETSEKSFFSRDQKQDN---- 1378
L +R EE Y L + L D + +S + ++KQ
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437
EKT + +D +E T L +++ + + +LER +F +
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497
+S ++ S +H L K +AL + + ++ D+L+ + K L+
Sbjct: 1510 MSSKDDVGKS----VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL----RLEVN 1561
Query: 1498 YASVKEENER-LQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQS 1556
++K + ER LQ + E +QL+++VR EL ++E K R ++ KL
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL---EDERKQRSMAVAARKKLEMD 1618
Query: 1557 LRVELKAY-----EKLDEEHRRLR 1575
L+ +L+A+ + DE ++LR
Sbjct: 1619 LK-DLEAHIDSANKNRDEAIKQLR 1641
Score = 63.2 bits (152), Expect = 2e-09
Identities = 226/1187 (19%), Positives = 445/1187 (37%), Gaps = 191/1187 (16%)
Query: 440 RNEVEKLRNE-----VNEREKAMENRYKSLLSESNK----KLHNQEQVIKHLTESTNQKD 490
R E E + E V E++ A ENR + + ++ KL QEQ ++ TE + +
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ-LQAETELCAEAE 900
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
L + K E +++ C+ DLE R E E+C Q +++KK +
Sbjct: 901 ELRARLTAKKQE-LEEICH-----DLEARVEEE-EERCQHLQ--------AEKKKMQQNI 945
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEE 610
+EL + L++E+ L + + + +A+L K+ + LE +K LE+
Sbjct: 946 QELEEQLEEEESARQKL-----QLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 611 QISE----IRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKE 666
+I+E + EE+S SL + + ++ + R + E ++EL+K ++
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR-------RK 1052
Query: 667 LYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSD 726
L D+ L I +L E LA KE+E + +E
Sbjct: 1053 LEGDSTDLSDQIAELQAQ------------IAELKMQLAKKEEELQAALARVEE------ 1094
Query: 727 QHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKAT 786
Q N +K + R ES+IS+ L+E + EK
Sbjct: 1095 -EAAQKNMALKKI----------RELESQISE---------LQEDLESERASRNKAEKQK 1134
Query: 787 LLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPH 846
L + LK E L ++ S + K ++ H Q + H
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 847 DELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLR-------------FKHEATREA 893
+ QL + V K L+ A G+L K +
Sbjct: 1195 SQAVEELAEQLEQTKRV-KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 894 WEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYR 953
+E + R E V Q L ++ G+ ++ KS L K +L + +
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK--LTKDFSALES--Q 1309
Query: 954 LPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPV 1013
L TQE++ + Q L L +LK+ + ++L E TL +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 1014 GAAYQDSPGEQKGIKTTSSVWR--DKEMDSDQQRSYEIDSEICPPDDLASLPS-CKENPE 1070
+DS G ++T V R K+++ QR E ++ D L + ++ +
Sbjct: 1370 KKKMEDSVG---CLETAEEVKRKLQKDLEGLSQRHEE---KVAAYDKLEKTKTRLQQELD 1423
Query: 1071 DVLSPTSVATYLSSKSQPSAKV--SVMGTDQSESINTSNETEYLKQKIHDLETEL----E 1124
D+L + + K ++ +++ S + E + + + + ET+
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483
Query: 1125 GYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVK 1184
+ + Q + + ++ T + ++D + K S+H++ K
Sbjct: 1484 ALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK-------------SVHELEKSKRAL 1530
Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKF-RDL------ 1237
+ +E +K QLEE E +LQ ++ ++L + ++ +F RDL
Sbjct: 1531 -----------EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVA-- 1295
S + LV+ Q RE+ + + + + V +R+ + +K E + +++ + A
Sbjct: 1580 SEEKKKQLVR-QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638
Query: 1296 --EGFQEQLNQCA-----------ELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLT 1342
Q Q+ C E+L + ++ KS+ EM E + E
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698
Query: 1343 YQHLLPESPEPSASH------ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLM 1396
Q E + A+ AL + E +++ + E T ++ + + L
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF------VQGS---------TSIFASG 1441
I +I T + NE R+QLERQ E ++G+ T++ A
Sbjct: 1759 --IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI 1816
Query: 1442 SELHSSLTSE-------IHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL 1494
++L L +E +R+ + L +L++ D+++ ++ ++ + + L+ L
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQL 1875
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+R+ +EE +R + +R + + +E+S ++ +++
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 62.8 bits (151), Expect = 3e-09
Identities = 137/622 (22%), Positives = 256/622 (41%), Gaps = 68/622 (10%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKF----RDLSPPRYDSLVQSQARELS 1254
+E L+ QL ++ +LQ++ +L +E L+ + ++L +D + + E
Sbjct: 871 METLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEER 930
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
Q Q + ++ M I+ EE L+ + + Q + L+KLE+
Sbjct: 931 CQHLQAE---------KKKMQQNIQELEEQLEEEE---SARQKLQLEKVTTEAKLKKLEE 978
Query: 1315 LFLNGKSVGVEMNTQNELME-RIEE--DNLTYQHLLPESPEPSASHALSDYE---TSEKS 1368
+ + ++ + +L+E RI E NLT + E S + + +E T +
Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE----EEKSKSLAKLKNKHEAMITDLEE 1034
Query: 1369 FFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-KTNEKLRKQLERQG 1427
R++KQ E EKT + S DL + I E++ L+ + K E+L+ L R
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDL-SDQIAELQAQIAELKMQLAKKEEELQAALARVE 1093
Query: 1428 SEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRK 1487
E Q + ++ EL S + SE+ + +A K RD +E + L+ L
Sbjct: 1094 EEAAQKNMAL-KKIRELESQI-SELQEDLESERASRNKAEKQKRDLGEELEALKTELE-D 1150
Query: 1488 TVSLEHLQREYASVKEENERLQKEGSEKE------------RHNQQLIQEVRCSGQELSR 1535
T+ Q+E S +E+ + K+ E+E + + Q ++E+ ++ R
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 1536 VQEEV-KLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSS 1594
V+ + K +Q L ++ +L ++V L+ K D EH+R + + E F+ +
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQG--KGDSEHKR-KKVEAQLQELQVKFNEGERV 1267
Query: 1595 QAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTP----CVSRLVTGHHLWASKNGRHVLG 1650
+ V++ N T LS S+ T S+L L +N R L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN-RQKLS 1326
Query: 1651 LIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLT 1710
L LKQ+ + E + +EA + +++ T A + K + T
Sbjct: 1327 L----STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 1711 LEEAYRRLKLLWRVSLPEDGQCPLHCEQIG---EMKAEVTKLHKKLFEQEKKLQN-TMKL 1766
EE R+L+ +G H E++ +++ T+L ++L + L +
Sbjct: 1383 AEEVKRKLQ------KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 1767 LQLSKRQEKVIFDQLVVTHKIL 1788
L K+Q+K FDQL+ K +
Sbjct: 1437 CNLEKKQKK--FDQLLAEEKTI 1456
Score = 62.0 bits (149), Expect = 5e-09
Identities = 78/402 (19%), Positives = 176/402 (43%), Gaps = 35/402 (8%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ- 118
+++ E+++ + L++ + ++ + +++ G E + +L +V ++ EL+
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 119 EREQ--LLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-RILLLEKDVTAAQ 175
ER+Q + + A K +E + + I ++ + ++Q+ L + + + E D T A
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK-------L 228
E E E EK L+ + +++ + A E+D L +E+ L
Sbjct: 1661 RE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 229 SLKSK---EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQME-HQKE 284
+L+ K EA I L+EE + E ++ + + + E + + ++
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA 1779
Query: 285 RNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE-LNSEIEK 343
R E + + L+ L+E E + ++ K S+ AL++K ++EE L++E ++
Sbjct: 1780 RQQLERQNKELKVKLQEMEGTVKSKYKASIT----------ALEAKIAQLEEQLDNETKE 1829
Query: 344 LSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403
AA + R +K + Q ++ A K+ A ST +L+R +++
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA--------STRLKQLKRQLEE 1881
Query: 404 ITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
+E R +L+++LE+A + + L+N++ +
Sbjct: 1882 AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 38.5 bits (88), Expect = 0.060
Identities = 82/428 (19%), Positives = 162/428 (37%), Gaps = 45/428 (10%)
Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIH 1453
LL QE + K EE +K EK + E + +E + + A +L L +E
Sbjct: 837 LLQVSRQEEEMMAKE-EELVKVREK-QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 1454 FLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGS 1513
L + + L A L ++ ++ L + + +HLQ E +++ + L+++
Sbjct: 895 -LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 1514 EKERHNQQLIQEVRCSGQELSRVQEE-VKLRQQ--LLSQNDKLLQSLRVEL--------- 1561
E+E Q+L E + +L +++EE + L Q L++ KLL+ E
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013
Query: 1562 --KAYEKLDEEH--------RRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGN 1611
K+ KL +H RLR +K E + + + ++E
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073
Query: 1612 DTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGR---HVLGLIEDYEALLKQISQGQRL 1668
L+ + V ++ K + L ED E+ ++ ++
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 1669 LAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPE 1728
++ + + + L + SK V+ K TLEE
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE--------------- 1178
Query: 1729 DGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKIL 1788
+ H QI EM+ + ++ ++L EQ ++ + L+ +K+ + +L K+L
Sbjct: 1179 --EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 1789 RKARGNLE 1796
+ +G+ E
Sbjct: 1237 LQGKGDSE 1244
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 98.2 bits (243), Expect = 6e-20
Identities = 152/690 (22%), Positives = 295/690 (42%), Gaps = 105/690 (15%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQ---QEFHGPTEHIYKTNIEL-KVEVESLKRE--- 116
+ Q+ L++E+ +L ++ +E +Q Q H + L +++ E+ RE
Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768
Query: 117 -LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
L + E+++++A+ A++G E+ R + ++ + L K L +++
Sbjct: 769 CLLQNEKIILEAALQA---AKSGKEELDRGARRLEEGTEETSETLEK----LREELAIKS 821
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA 235
++E T K +++ + + K M E A KD+LI ELK + K ++
Sbjct: 822 GQVEHLQQETAALKKQMQKIKEQFLQQKVMVE---AYRRDATSKDQLISELKATRKRLDS 878
Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER--ETEAAQMEHQKERNSFEERIQ 293
++ L++E Q+ ++ + EL L + ++ + E QKER+ E +Q
Sbjct: 879 ELKELRQELMQVH-GEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQ 937
Query: 294 ALE--------------------EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKK 333
+L+ E+L+++ R+ TE+K ++R + LT A K + K
Sbjct: 938 SLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGS--DLTSAQKEMKTK 995
Query: 334 VEELNSEIEKLSAAFAKAREALQKAQTQEFQ-----GSEDYETALSGK-EALSAALRSQN 387
+ + + LS +A A + A + Q GS D AL + +AL A L++ +
Sbjct: 996 HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVS 1055
Query: 388 LTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
+K+ L+ I +QEL + +++ LE +L+E+ + K I+ L +KL
Sbjct: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK----IKRLEESNKKLA 1111
Query: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIK--------HLTESTNQKDVLLQKFNEK 499
E+ + + L +SN L +++ L + Q +LQ+ E+
Sbjct: 1112 LELEHEKGKLTG-----LGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166
Query: 500 DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPG---------SKTIFSKEKKQSSDY 550
D ++ L A+ + E + E+ ++ + + S+ KK+
Sbjct: 1167 DRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK 1226
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA----LRKQLEQDVLSY----- 601
E L+Q L+ E D ++ + S I QAEL + A L+KQL++ +
Sbjct: 1227 EHLVQKLQAEADDLQ--IREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQ 1284
Query: 602 --QNLRKTLEEQISEIR-------------RREEESFS-LYSDQTSYLSICLEENNRFQV 645
+NL+ ++++ EI+ R+E E L + S L + E+ + Q
Sbjct: 1285 EMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQK 1344
Query: 646 EHFSQEELKKKVSDLIQLVKELYTDNQHLK 675
+ F L+ KVS+L +K L NQ LK
Sbjct: 1345 DKFM---LQAKVSELKNNMKTLLQQNQQLK 1371
Score = 78.6 bits (192), Expect = 5e-14
Identities = 127/581 (21%), Positives = 240/581 (41%), Gaps = 64/581 (11%)
Query: 106 LKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRIL 165
LK+E SL ++L E + +K + A+ G E + ++A Q+++ T
Sbjct: 613 LKLENVSLSQQLTETQHRSMKEKGRIA--AQLQGIEADMLDQEAA--FMQIQEAKT---- 664
Query: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK-KMHEGDLAMALVLDEKDRLIE 224
++E+D+ E E + LE +L ++K + + D + + E L++
Sbjct: 665 MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724
Query: 225 ELKLS---LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH 281
+L L+ L+S+E + L+ ++ GEL+G E RE +
Sbjct: 725 QLTLTQEALQSREQSLDALQTHYDEL-----QARLGELQG------EAASREDTICLL-- 771
Query: 282 QKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEI 341
Q E+ E +QA + E +R ++ + + + ++ L L K +VE L E
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE- 830
Query: 342 EKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSI 401
+AA K + +++ Q+ E Y + K+ L + L++ RL +
Sbjct: 831 ---TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATR-------KRLDSEL 880
Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMEN-- 459
K++ QEL + E+ E +L HRE ++ + DL ++ + E +E E +++
Sbjct: 881 KELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ 940
Query: 460 ---RYKSLLSESNKKLHN-----QEQVIKHLTESTNQKDVLLQKFNEKDLEV-IQQNCYL 510
++E+N+ L Q++ K +TE + L E+ + Y
Sbjct: 941 FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYE 1000
Query: 511 MAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTH---- 566
A L R + + K ++ G S E IQ L+ E +H
Sbjct: 1001 NAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL 1060
Query: 567 LVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREE--ESFS 624
L K LQE ++ + + E ++ L +LE ++ + RK +I+R EE + +
Sbjct: 1061 LEKELQEVIALTSQELEESREKVL--ELEDELQESRGFRK-------KIKRLEESNKKLA 1111
Query: 625 LYSDQTSYLSICLEENNRFQVEHFS--QEELKKKVSDLIQL 663
L + L ++N EH S + L K+ +DL+QL
Sbjct: 1112 LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Score = 57.8 bits (138), Expect = 1e-07
Identities = 203/1130 (17%), Positives = 429/1130 (37%), Gaps = 136/1130 (12%)
Query: 275 EAAQMEHQKERNSFEERIQA----------LEEDLREKEREIATEKKNSLKRDKAIQGLT 324
+AA EHQ + +++ LE E + E+ K ++ + ++ L+
Sbjct: 366 QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
Query: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR 384
+ K+ EL +++ LS E +Q ++ S + +T L A+
Sbjct: 426 LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
Query: 385 SQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE 444
+N L S +L +++ +RL +E+ R D T+ DLR ++
Sbjct: 486 DLQNMLEAKNASLASS----NNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMT 541
Query: 445 KLRNEVNE---REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDL 501
L++++ + + ++ K+ +E + L + Q + + V LQ E
Sbjct: 542 ALQSQLQQVQLERTTLTSKLKASQAEIS-SLQSVRQWYQQQLALAQEARVRLQ--GEMAH 598
Query: 502 EVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQ 561
+ Q E L+L + L SQQ ++ KEK + + + I+ +Q
Sbjct: 599 IQVGQMTQAGLLEHLKLENVSL------SQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
Query: 562 DIYTHLVKSLQESDSI--NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRRE 619
+ +QE+ ++ +LQ L + R++L++ S +L + LE+ + +R+
Sbjct: 653 EA---AFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRD 709
Query: 620 EESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIF 679
++ +L + + Q S + L+ +L + EL + + TI
Sbjct: 710 QQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTIC 769
Query: 680 DL--------SCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQ 731
L + + +G + + E + E K+ E+ I +HLQQ
Sbjct: 770 LLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQ 829
Query: 732 SNEIMKD---------LSKGGCKNGYLRHTESK---ISDCDGAHAPGCLEEGAFINLLAP 779
+K L + Y R SK IS+ E L
Sbjct: 830 ETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQ 889
Query: 780 LFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQT 839
+ EK T + +L ++ RE+ + + + L+G + K++ E+ +Q+
Sbjct: 890 VHGEKRT----AEAELSRLHREVAQVRQHMAD-------LEGHLQSAQKERDEMETHLQS 938
Query: 840 NSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPI 899
F K Q+V E + A + + + EA + E+K
Sbjct: 939 LQFDK----------EQMVAVTEANE-----------ALKKQIEELQQEARKAITEQKQK 977
Query: 900 NTAL-----SAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRL 954
L SA+ + H A + GI +R +++ L LG +
Sbjct: 978 MRRLGSDLTSAQKEMKTKH------KAYENAVGILSRRLQEA-LAAKEAADAELGQLRAQ 1030
Query: 955 PATQEVVTQLQSQILELQGELKEFKTCNKQLHQKL--ILAEAVMEGRPTPDKTLLNAQPP 1012
+ + L +I L+ EL+ L ++L ++A E + +K L
Sbjct: 1031 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL-----E 1085
Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSY-----EIDSEICPPDDLASLPSCKE 1067
+ Q+S G +K IK + ++ + ++ + ++ + + + K
Sbjct: 1086 LEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKR 1145
Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127
+ V V L K + ++ + +++ S E E K+K++ L+ ++ +
Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKHL----VQALQASLEKE--KEKVNSLKEQVAAAK 1199
Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187
++H + + ++ + A++ L + K ++ +++ Q+R KH + +
Sbjct: 1200 VEAGHNRRHFKAASLELSEVKKELQAKEHLVQ-KLQAEADDL------QIREGKHSQEIA 1252
Query: 1188 PLAPEMIDSRV-LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLV 1246
E+ ++R L+ L++QL+EQ L K+ N ++ + + K R+ +
Sbjct: 1253 QFQAELAEARAQLQLLQKQLDEQ---LSKQPVGNQEMENLKWEVDQKERE---------I 1300
Query: 1247 QSQARELSLQRQQ-IKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305
QS ++L L QQ K+ G+ + + + + A E+L + + E N
Sbjct: 1301 QSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNM 1360
Query: 1306 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355
LL++ ++L L+ + + T+ E N +P+ P P++
Sbjct: 1361 KTLLQQNQQLKLDLRRGAAK--TRKEPKGEASSSNPATPIKIPDCPVPAS 1408
Score = 57.0 bits (136), Expect = 2e-07
Identities = 84/438 (19%), Positives = 186/438 (42%), Gaps = 54/438 (12%)
Query: 55 TRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLK 114
T ++++ + Q+ + + N LK +I L++ ++ + + + +L + +K
Sbjct: 934 THLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMK 993
Query: 115 RE----------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
+ L R Q + A +A + AE G Q D+ + + L +
Sbjct: 994 TKHKAYENAVGILSRRLQEALAAKEAAD--AELGQLRAQGGSSDSSLALHERIQALEAEL 1051
Query: 165 LLLEKDVTAAQAELEKAFAGTETE----KALRLRLESKLSE-------MKKMHEGDLAMA 213
+ T + EL++ A T E + L LE +L E +K++ E + +A
Sbjct: 1052 QAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLA 1111
Query: 214 LVLD-EKDRL--IEELKLSLKSKEALIQ-CLKEEKSQMACPDENVSSGELRGLCAAPREE 269
L L+ EK +L + + +L+ ++++ L + ++ + + V + R +EE
Sbjct: 1112 LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR------KEE 1165
Query: 270 KERETE------AAQMEHQKER-NSFEERIQALEEDLREKER-------EIATEKKNSLK 315
++R+ + A +E +KE+ NS +E++ A + + R E++ KK
Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQA 1225
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ-------GSED 368
++ +Q L + + + + EI + A A+AR LQ Q Q + G+++
Sbjct: 1226 KEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQE 1285
Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE 428
E + ++S + R+ ++ + Q L +++ E E ++DL ++
Sbjct: 1286 MENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKD 1345
Query: 429 KSKGDCTIRDLRNEVEKL 446
K + +L+N ++ L
Sbjct: 1346 KFMLQAKVSELKNNMKTL 1363
Score = 54.3 bits (129), Expect = 1e-06
Identities = 125/623 (20%), Positives = 244/623 (39%), Gaps = 81/623 (13%)
Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAY 1017
QE T ++ +LQ L+EF+ ++L + A ++ + TLL + A
Sbjct: 660 QEAKTMVEE---DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
Query: 1018 QDSPGEQKGIKTTSSVWRDKEMDSD---------QQRSYEIDSEICPPDDLASLPSCKEN 1068
Q+ K + T + +E D Q R E+ E +D C
Sbjct: 717 QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI----CLLQ 772
Query: 1069 PEDVLSPTSVATYLSSKSQ--PSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126
E ++ ++ S K + A+ GT++ TS E L++++ ++E
Sbjct: 773 NEKIILEAALQAAKSGKEELDRGARRLEEGTEE-----TSETLEKLREELAIKSGQVEHL 827
Query: 1127 QNFIFQLQKHSQ-CSEAIITVLCGTEG-AQDGLSKPKNGSDGE------EMTFSSLHQVR 1178
Q L+K Q E + E +D SK + S+ + + L Q
Sbjct: 828 QQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQEL 887
Query: 1179 YVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ------- 1231
H + A R + ++Q + + E LQ Q ++ + + +LQ
Sbjct: 888 MQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMV 947
Query: 1232 --NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASD 1289
+ + + + L Q + ++ Q+Q+++ +++ M T KA+E +
Sbjct: 948 AVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGI-- 1005
Query: 1290 VDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
++ QE L +L +L G S ++ L ERI Q L E
Sbjct: 1006 ----LSRRLQEALAAKEAADAELGQLRAQGGS----SDSSLALHERI-------QALEAE 1050
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409
S S L + E E + Q+ E + V+ L + +QE R RK++
Sbjct: 1051 LQAVSHSKTLLEKELQEVIALT---SQELEESREKVLE-------LEDELQESRGFRKKI 1100
Query: 1410 EESIKTNEKLRKQLERQGSEFV---QGSTSIFASGSELHSSLTSEIHFLRKQNQALNAML 1466
+ ++N+KL +LE + + Q + ++ S L ++L L + N + A+L
Sbjct: 1101 KRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVL 1160
Query: 1467 IKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEV 1526
+ K++E+ +++ + SLE + + S+KE+ + E RH
Sbjct: 1161 ----QRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRH-------F 1209
Query: 1527 RCSGQELSRVQEEVKLRQQLLSQ 1549
+ + ELS V++E++ ++ L+ +
Sbjct: 1210 KAASLELSEVKKELQAKEHLVQK 1232
Score = 52.4 bits (124), Expect = 4e-06
Identities = 162/789 (20%), Positives = 298/789 (37%), Gaps = 97/789 (12%)
Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKV--------SV 1094
Q Y ++ + P D L PS K DVL + A + + + +V S
Sbjct: 339 QDTPYMVNGQEIPADTLGQFPSIK----DVLQ-AAAAEHQDQGQEVNGEVRSRRDSICSS 393
Query: 1095 MGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQ 1154
+ + S + + LK+K+ LE +LE Q K +A + L AQ
Sbjct: 394 VSLESSAAETQEEMLQVLKEKMR-LEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQ 452
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID-SRVLENLKQQLEEQEYKL 1213
S + S + + SS +V +K + L M D +LE L L
Sbjct: 453 VECS---HSSQQRQDSLSS--EVDTLK--QSCWDLERAMTDLQNMLEAKNASLASSNNDL 505
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQH 1273
Q + +L +++ ++Q +D Q A + LQ+ Q++ R
Sbjct: 506 QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLE---------RTT 556
Query: 1274 MNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM 1333
+ + +KA + + + V + +Q+QL E +L+ + + V TQ L+
Sbjct: 557 LTSKLKASQAEISSLQ---SVRQWYQQQLALAQEARVRLQGEMAH---IQVGQMTQAGLL 610
Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393
E ++ +N++ L E+ S ++ D + ++
Sbjct: 611 EHLKLENVSLSQQLTETQHRSMKE--KGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEE 668
Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSE---LHSSLTS 1450
L ++E R+RL+ + L +QLE+ +Q + A E L LT
Sbjct: 669 DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTL 728
Query: 1451 EIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRK-TVSLEHLQREYASVKEENERLQ 1509
L+ + Q+L+A+ + + + E+ SR+ T+ L LQ E ++ + +
Sbjct: 729 TQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICL--LQNEKIILEAALQAAK 786
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDE 1569
E +R ++L + + + L +++EE+ ++ Q + L Q K +K+ E
Sbjct: 787 SGKEELDRGARRLEEGTEETSETLEKLREELAIKS---GQVEHLQQETAALKKQMQKIKE 843
Query: 1570 EHRRLR-DGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTP 1628
+ + + + Y ++ + L +A + SE L L G T+
Sbjct: 844 QFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKEL----RQELMQVHGEKRTAEA 899
Query: 1629 CVSRL-------------VTGHHLWASK--------------NGRHVLGLIEDYEALLKQ 1661
+SRL + GH A K + ++ + E EAL KQ
Sbjct: 900 ELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQ 959
Query: 1662 I----SQGQRLLAEMDIQTQEAPSS-TSQELGTKGPHPA------PLSKFVSSVSTAKLT 1710
I + ++ + E + + S TS + K H A LS+ + AK
Sbjct: 960 IEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAK-- 1017
Query: 1711 LEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLL--Q 1768
E A L L D LH E+I ++AE+ + EK+LQ + L +
Sbjct: 1018 -EAADAELGQLRAQGGSSDSSLALH-ERIQALEAELQAVSHSKTLLEKELQEVIALTSQE 1075
Query: 1769 LSKRQEKVI 1777
L + +EKV+
Sbjct: 1076 LEESREKVL 1084
Score = 47.0 bits (110), Expect = 2e-04
Identities = 197/1128 (17%), Positives = 423/1128 (37%), Gaps = 180/1128 (15%)
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
S E + EE++QVLK++ + L E+ +AEL A
Sbjct: 395 SLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA---------- 444
Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
L L+ Q+ ++ SL S+ + C + L++ ++DL
Sbjct: 445 ---LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD--------------LERAMTDL 487
Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
+++ N L + DL ++A + L+A ED + +D+
Sbjct: 488 QNMLE---AKNASLASSNNDL------------QVAEEQYQRLMAKVEDMQRSMLSKDNT 532
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
++ L Q +++ + + L+ ++++IS + +
Sbjct: 533 VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS---------------LQSVRQW 577
Query: 781 FNEKATLLLESRPDLLKVVRELLLGQL-------FLTEQEVS-GEHLDGKTEKTPKQKGE 832
+ ++ L E+R L + + +GQ+ L + VS + L ++ K+KG
Sbjct: 578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGR 637
Query: 833 LVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE 892
+ +Q L EA ++ E + +D + EG+ R + A
Sbjct: 638 IAAQLQGIEADM------LDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSA 691
Query: 893 AWEEKPINTA-LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNM 951
A E+ + L+ R + L + L+ +T +EA +SR
Sbjct: 692 ASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLT-QEALQSR-------------E 737
Query: 952 YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQP 1011
L A Q +LQ+++ ELQGE + L + I+ EA ++ + + L
Sbjct: 738 QSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG-- 795
Query: 1012 PVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
A + G ++ +T + + + S Q + ++ + KE +
Sbjct: 796 ----ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQ----MQKIKE--QF 845
Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHD----LETELEGYQ 1127
+ V Y + +S + + + E ++H E EL
Sbjct: 846 LQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLH 905
Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187
+ Q+++H + EG K ++ + + L +++ K +
Sbjct: 906 REVAQVRQH----------MADLEGHLQSAQKERDEME------THLQSLQFDKEQMVAV 949
Query: 1188 PLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRD-------LSPP 1240
A E + ++ E ++ + + QK + L L S ++ K + LS
Sbjct: 950 TEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRR 1009
Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA-SDVDYCVAEGFQ 1299
++L +A + L + + + G ++ ++ I+A E LQA S + + Q
Sbjct: 1010 LQEALAAKEAADAELGQLRAQGGSSDSSLA---LHERIQALEAELQAVSHSKTLLEKELQ 1066
Query: 1300 EQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDN----LTYQHLLPESPEPSA 1355
E + ++ LE+ + L + E + ++R+EE N L +H +
Sbjct: 1067 EVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQ 1126
Query: 1356 SHA-LSDYETSEKSFFSRDQKQ--DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEES 1412
S+A L ++ + ++ ++ + + +V+ +D M+H+ ++ L+ LE+
Sbjct: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHL--VQALQASLEKE 1184
Query: 1413 IKTNEKLRKQLERQGSEFVQGSTSIFASG---SELHSSLTSEIHFLRKQNQALNAMLIKG 1469
+ L++Q+ E A+ SE+ L ++ H ++K + + I+
Sbjct: 1185 KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244
Query: 1470 SRDKQKE-----------------NDKLRESLSRKTVSLEHLQ----------REYASVK 1502
+ Q+ +L E LS++ V + ++ RE S+K
Sbjct: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
Query: 1503 EENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ----LLSQNDKLLQSLR 1558
++ + +++G ++ QQL+Q V+ EL QE++ + Q+ L ++ +L +++
Sbjct: 1305 QQLDLTEQQGRKELEGLQQLLQNVK---SELEMAQEDLSMTQKDKFMLQAKVSELKNNMK 1361
Query: 1559 VELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETP 1606
L+ ++L + RR + + + S SS TP + + P
Sbjct: 1362 TLLQQNQQLKLDLRRGAAKTRKEPKGEAS-----SSNPATPIKIPDCP 1404
Score = 43.5 bits (101), Expect = 0.002
Identities = 72/375 (19%), Positives = 164/375 (43%), Gaps = 31/375 (8%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ F +I L++ N L L + + G + ++N L+ L+ L +R
Sbjct: 1094 RGFRKKIKRLEESNKKLALEL--------EHEKGKLTGLGQSNAALREHNSILETALAKR 1145
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK---RILLLEKDVTAAQAE 177
E L++ + V+++ + E +++K VQ ++ L K ++ L++ V AA+ E
Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKH----LVQALQASLEKEKEKVNSLKEQVAAAKVE 1201
Query: 178 L---EKAFAGTETEKA-LRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
+ F E + ++ L++K ++K+ + + + + I + + L
Sbjct: 1202 AGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEA 1261
Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQ 293
A +Q L+++ + + V + E+ L ++KERE ++ + + + ++
Sbjct: 1262 RAQLQLLQKQLDEQLSK-QPVGNQEMENL-KWEVDQKEREIQSLKQQLDLTEQQGRKELE 1319
Query: 294 ALEEDLR--EKEREIATEKKNSLKRDK-AIQGLTMALKSKEKKVEELNSEIE-KLSAAFA 349
L++ L+ + E E+A E + ++DK +Q LK+ K + + N +++ L A
Sbjct: 1320 GLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAA 1379
Query: 350 KAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS 409
K R+ + + S + T + + A + L + + +K + L
Sbjct: 1380 KTRK-----EPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVS-KEPLKNLNSCLQ 1433
Query: 410 DLQQERERLEKDLEE 424
L+QE + L++ +EE
Sbjct: 1434 QLKQEMDSLQRQMEE 1448
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 96.7 bits (239), Expect = 2e-19
Identities = 142/623 (22%), Positives = 294/623 (47%), Gaps = 83/623 (13%)
Query: 66 QITELKKENFNLKLRIYFLEERMQQEFHGPTE--HIYKTNIELKVEVESLKRELQEREQL 123
+ +L+K N +L+I L+E++++ TE + + + K E +LQ RE
Sbjct: 623 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRED- 681
Query: 124 LIKASKAV-ESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF 182
+S+ + + L EA E++ +A+ Q +E L ++ E+ + +++K
Sbjct: 682 ---SSEGIRKKLVEA--EELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDL 736
Query: 183 AGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEE--LKLSLKSKEALIQCL 240
A ET + + R E + E K+ AM +D K R +E+ ++LS +K A L
Sbjct: 737 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 796
Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALE-EDL 299
+++ M +E +S ELR +++ ET+A ++E Q + EE+++ + +D
Sbjct: 797 FTQRN-MKAQEEMIS--ELR------QQKFYLETQAGKLEAQNRK--LEEQLEKISHQDH 845
Query: 300 REKEREIATE---KKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
+K R + E ++ SL+ ++ L L + ++E S++ L AA A L+
Sbjct: 846 SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 905
Query: 357 KAQTQEFQGSEDYETALSGKEALSA----------ALRSQNLTKSTENHRLRRSIKKITQ 406
+A+T+ + + + E + +AL+A ALR+ + T T+ L + ++T+
Sbjct: 906 QAKTELEETTAEAEEEI---QALTAHRDEIQRKFDALRN-SCTVITD---LEEQLNQLTE 958
Query: 407 ELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLS 466
+ ++L + L K L+EA S + I LR+EV+ LR E+ ERE + ++ +++ +
Sbjct: 959 DNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 1014
Query: 467 ESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDL-------EVIQQNCYLMAAEDLELR 519
+EQV+ E+ N D LL+K + + E Q C + + +
Sbjct: 1015 LKTTCTMLEEQVMD--LEALN--DELLEKERQWEAWRSVLGDEKSQFECRVRELQRM--- 1067
Query: 520 SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINN 579
L TEK S+ + S++ + + E ++L +Q + +K+ SD +N+
Sbjct: 1068 ---LDTEK-QSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLND 1123
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEE 639
L+ + + + L+Q + + + L++ L E+ ++++++ + L++
Sbjct: 1124 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD----------------LQK 1167
Query: 640 NNRFQVEHFSQEELKKKVSDLIQ 662
N+ F++ QE L + +DL++
Sbjct: 1168 NHIFRLTQGLQEALDR--ADLLK 1188
Score = 73.9 bits (180), Expect = 1e-12
Identities = 124/576 (21%), Positives = 241/576 (41%), Gaps = 81/576 (14%)
Query: 160 LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDE 218
+ K++L+ K++ +Q + K E E RL ++SE++ + + ++ + +
Sbjct: 447 MEKKLLIKSKELQDSQDKCHKM----EQEMT---RLHRRVSEVEAVLSQKEVELKASETQ 499
Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
+ L ++L + +L + L++ + +++ D+ L RE+ + E +
Sbjct: 500 RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQ-----LLHDIREQSRKLQEIKE 554
Query: 279 MEHQKERNSFEERIQALEEDL--------------------REKEREIATEKKNSLKRDK 318
E+Q + + LEEDL E+ + ATE ++ L + K
Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAK 614
Query: 319 AIQG---------LTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369
QG L ++ K++EL ++EK A +A E LQ + + + +
Sbjct: 615 D-QGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 673
Query: 370 ETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS-DLQQERERLEKDLEEAHRE 428
E L +E S +R + L ++ E R + Q L L+Q+ + E+ ++ +
Sbjct: 674 E-KLQNREDSSEGIR-KKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQ 731
Query: 429 KSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTEST-- 486
K L N +++ E +E+ K + + K++++ + K+ + EQ I L+E+
Sbjct: 732 IKKDLADKETLENMMQRHEEEAHEKGKILSEQ-KAMINAMDSKIRSLEQRIVELSEANKL 790
Query: 487 -------NQKDVLLQKFNEKDLEVIQQNCYL-MAAEDLELRSEGL--ITEKCSSQQPPGS 536
Q+++ Q+ E E+ QQ YL A LE ++ L EK S Q
Sbjct: 791 AANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848
Query: 537 KTIFSKE---KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDS-INNLQAELNKIFALRK 592
+ E ++ S ++EE LK++ T L SLQE +S + LQA AL
Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQ---LTELQLSLQERESQLTALQAAR---AALES 902
Query: 593 QLEQDVLSYQNLRKTLEEQISEIRRREEE----------SFSLYSDQTSYLSICLEENNR 642
QL Q + EE+I + +E S ++ +D L+ E+N
Sbjct: 903 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 962
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
++F + + S + +L ++ HL++ I
Sbjct: 963 LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREI 998
Score = 69.7 bits (169), Expect = 2e-11
Identities = 102/435 (23%), Positives = 186/435 (42%), Gaps = 47/435 (10%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E A+N K E Q+ ++ ++ + K R+ LE R+++ EH + +ELK
Sbjct: 820 ETQAGKLEAQNRK-LEEQLEKISHQDHSDKNRLLELETRLREV---SLEH-EEQKLELKR 874
Query: 109 EVESLKRELQEREQLLIK---ASKAVESLAEAGGSEIQRVKEDARKKVQQV---EDLLTK 162
++ L+ LQERE L A A+ES +E++ +A +++Q + D + +
Sbjct: 875 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR 934
Query: 163 RILLLEKDVTAAQAELEKAFAGTETEKALRLR---LESKLSEMKKMHEGDLAMALVLDEK 219
+ L T E+ TE L + L +L E ++ + + +D
Sbjct: 935 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 994
Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMA--CPDENVSSGELRGLCAAPREEKERETEAA 277
R I E ++ L S++ ++ LK + + D + EL EKER+ EA
Sbjct: 995 RREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELL--------EKERQWEAW 1046
Query: 278 QMEHQKERNSFEERIQAL------EEDLREKEREIATEKKN----SLKRDKA-IQGLTMA 326
+ E++ FE R++ L E+ R + + TE + ++K KA I L A
Sbjct: 1047 RSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQA 1106
Query: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386
LK ++ K E L+ ++ L + + A+ + + Q + E L + L + Q
Sbjct: 1107 LKEQKLKAESLSDKLNDL-----EKKHAMLEMNARSLQQKLETERELK-QRLLEEQAKLQ 1160
Query: 387 NLTKSTENH--RLRRSIKKITQELSDLQQERERLEKDLEEAH----REKSKGDCTIRDLR 440
+NH RL + +++ L+ ER LE LE EK K + TI
Sbjct: 1161 QQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQT 1220
Query: 441 NEVEKLRNEVNEREK 455
++ L+ ++++ K
Sbjct: 1221 KLIDFLQAKMDQPAK 1235
Score = 57.8 bits (138), Expect = 1e-07
Identities = 76/346 (21%), Positives = 140/346 (40%), Gaps = 54/346 (15%)
Query: 62 DFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE 121
D E Q+ +L ++N L + ++L +++ E G + I ++L+ EV+ L+RE+ ERE
Sbjct: 948 DLEEQLNQLTEDNAELNNQNFYLSKQLD-EASGANDEI----VQLRSEVDHLRREITERE 1002
Query: 122 QLLIKASKAVESLA-----------------------------------------EAGGS 140
L + +E+L E
Sbjct: 1003 MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVR 1062
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLS 200
E+QR+ + ++ + + +T+ ++E V +AE+ + +K L KL+
Sbjct: 1063 ELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 1122
Query: 201 EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA-LIQCLKEEKSQMACPDENVSSG-E 258
+++K H A L +K ELK L ++A L Q + +K+ + + + +
Sbjct: 1123 DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD 1182
Query: 259 LRGLCAAPREEKERETEAAQMEHQKERNSFEERIQ---ALEEDLREKEREIATEKKNSLK 315
L R + E + E Q+ + E+ E I L + L+ K + A +KK
Sbjct: 1183 RADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS 1242
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
R K L + + EL +EK A A+ EALQK + +
Sbjct: 1243 RRKEDPALPTQV---PLQYNELKLALEKEKARCAELEEALQKTRIE 1285
Score = 52.0 bits (123), Expect = 5e-06
Identities = 165/763 (21%), Positives = 300/763 (39%), Gaps = 131/763 (17%)
Query: 465 LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLI 524
L +S K H EQ + L ++ + +L + E +L+ + L+ +DL I
Sbjct: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ-KEVELKASETQRSLLE-QDLAT----YI 511
Query: 525 TEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLK--KEQDIYTHLVKSLQESDSINNLQA 582
TE CSS + +++ + S + ++ +Q+L +EQ + LQE QA
Sbjct: 512 TE-CSSLK----RSLEQARMEVSQEDDKALQLLHDIREQS------RKLQEIKE-QEYQA 559
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
++ ++ + QLE+D++S + E ++ E R EE F + + + + ++ +
Sbjct: 560 QVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE-FKRKATECQHKLLKAKDQGK 618
Query: 643 FQVEHFS----------------QEELKKKV---SDLIQLVKELYTDNQHLKKTIFDLSC 683
+V ++ QE+L+K V ++ +L++ + + ++ + L
Sbjct: 619 PEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQN 678
Query: 684 MGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQ-----SNEIMKD 738
G +L E+ E K E + + +QH ++ N+I KD
Sbjct: 679 REDSSEGIRKKLVEAEELE---EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 735
Query: 739 LS-KGGCKNGYLRHTESKISDCDGAHAPGCL--EEGAFINLLAPLFNEKATLLLE-SRPD 794
L+ K +N RH E AH G + E+ A IN + ++E S +
Sbjct: 736 LADKETLENMMQRHEEE-------AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 788
Query: 795 LL----------------KVVRELLLGQLFLTEQ----EVSGEHLDGKTEKTPKQ----K 830
L +++ EL + +L Q E L+ + EK Q K
Sbjct: 789 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848
Query: 831 GELVHF-VQTNSFSKPHDELKLSCEAQLVK---AGEVPKVGLKDASVQTVATEGDLLRFK 886
L+ + S H+E KL + QL + + + + L A E L + K
Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 908
Query: 887 ---HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIK 943
E T EA EE TA HR E + A S IT+ E +L L +
Sbjct: 909 TELEETTAEAEEEIQALTA----HRDEIQR---KFDALRNSCTVITDLE---EQLNQLTE 958
Query: 944 PSRSLGN--------MYRLPATQEVVTQLQSQILELQGELKEFK---TCNKQLHQKL--- 989
+ L N + + + QL+S++ L+ E+ E + T KQ + L
Sbjct: 959 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 1018
Query: 990 --ILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSY 1047
+L E VM+ D+ L + A++ G++K + +D+++Q
Sbjct: 1019 CTMLEEQVMDLEALNDELLEKERQ--WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRA 1076
Query: 1048 EIDSEICPPDDLASLPSCKENPEDVLSPTSV-------ATYLSSKSQPSAKVSVMGTDQS 1100
D I + L + KE+ ++L+ A LS K K M +
Sbjct: 1077 RADQRITESRQVVEL-AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNA 1135
Query: 1101 ESINTSNETE-YLKQKIHD----LETELEGYQNFIFQLQKHSQ 1138
S+ ETE LKQ++ + L+ +++ +N IF+L + Q
Sbjct: 1136 RSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ 1178
Score = 48.9 bits (115), Expect = 4e-05
Identities = 112/553 (20%), Positives = 210/553 (37%), Gaps = 87/553 (15%)
Query: 1086 SQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIIT 1145
++ K+ + +++ S E L Q I + E + +LQ SE I
Sbjct: 632 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE---RELEKLQNREDSSEGIRK 688
Query: 1146 VLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL-GPLAPEMIDSRVLENLKQ 1204
L E ++ + + + E+ Q Y + +K+L + ++ D LEN+ Q
Sbjct: 689 KLVEAEELEEKHREAQVSAQHLEVHLKQKEQ-HYEEKIKVLDNQIKKDLADKETLENMMQ 747
Query: 1205 QLEEQEYK----LQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
+ EE+ ++ L +++ + + S+I +L+ + +LS +A +L+
Sbjct: 748 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS----------EANKLAANSS-- 795
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
+ ++++M + EL Q A + Q + E LEK+ + K
Sbjct: 796 -------LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848
Query: 1321 SVGVEMNTQ-NELMERIEEDNLTYQHLLPE---SPEPSASHALSDYETSEKSFFSRDQKQ 1376
+ +E+ T+ E+ EE L + L E S + S L+ + + + S+ ++
Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ-LTALQAARAALESQLRQA 907
Query: 1377 DNETEKTSVMVNSFSQ-------------DLLMEHIQEIRTLRKRLEESIKTNEKLRKQ- 1422
E E+T+ Q D L I L ++L + + N +L Q
Sbjct: 908 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQN 967
Query: 1423 --LERQGSEFVQGSTSIFASGSE---LHSSLTSEIHFLRKQNQALNA------MLIKGSR 1471
L +Q E + I SE L +T L Q Q + A ML +
Sbjct: 968 FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 1027
Query: 1472 DKQKENDKLRES--------------LSRKTVSLEHLQREYASVKEENERLQKEGSEKER 1517
D + ND+L E S+ + LQR + K+ R + +E +
Sbjct: 1028 DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 1087
Query: 1518 HNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQ--ND-------------KLLQSLRVELK 1562
+ ++E + L + +E KL+ + LS ND L Q L E +
Sbjct: 1088 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERE 1147
Query: 1563 AYEKLDEEHRRLR 1575
++L EE +L+
Sbjct: 1148 LKQRLLEEQAKLQ 1160
Score = 48.5 bits (114), Expect = 6e-05
Identities = 95/460 (20%), Positives = 173/460 (37%), Gaps = 78/460 (16%)
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQ------------- 1247
+LK+ LE+ ++ +E + +QL +I K +++ Y + V+
Sbjct: 516 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDL 575
Query: 1248 -SQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDV------DYCVAEGFQ- 1299
S R L ++++ + + + + +LL+A D +Y E
Sbjct: 576 VSARRRSDLYESELRESR---LAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINA 632
Query: 1300 EQLNQCAELLEKLEK----------LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
EQ + EL EKLEK L N + + E ++ E+ + + L E
Sbjct: 633 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVE 692
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL---------LMEHIQ 1400
+ E H + + QK+ + EK V+ N +DL + H +
Sbjct: 693 AEELEEKHREAQVSAQHLEVHLK-QKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEE 751
Query: 1401 EIRTLRKRLEES---IKTNEKLRKQLERQGSEF-----VQGSTSIFASG---------SE 1443
E K L E I + + LE++ E + ++S+F SE
Sbjct: 752 EAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISE 811
Query: 1444 LHSS---LTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSR-KTVSLEHLQREYA 1499
L L ++ L QN+ L L K S + ++L E +R + VSLEH + +
Sbjct: 812 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEH-EEQKL 870
Query: 1500 SVKEENERLQKEGSEKERH-------NQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDK 1552
+K + LQ E+E L ++R + EL E + Q L+ +
Sbjct: 871 ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 930
Query: 1553 LLQ----SLRVELKAYEKLDEEHRRLRDGDKYPMESDNSF 1588
+Q +LR L+E+ +L + D + + N +
Sbjct: 931 EIQRKFDALRNSCTVITDLEEQLNQLTE-DNAELNNQNFY 969
Score = 38.1 bits (87), Expect = 0.078
Identities = 89/415 (21%), Positives = 156/415 (37%), Gaps = 53/415 (12%)
Query: 1389 SFSQDLLMEHIQEIRTLRKRLEESIKTN-----EKLRKQLERQGSEFVQGSTSIFASGSE 1443
S D ++ + +IR ++L+E + E++R + + + V SE
Sbjct: 529 SQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE 588
Query: 1444 LHSSLTSEIHFLRKQNQALNAMLIKGSRDKQK--ENDKLRESLSRKTVSLEHLQREYASV 1501
L S + F RK + + +L + K + E KL + + + + ++ LQ +
Sbjct: 589 LRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKA 648
Query: 1502 ----KEENERLQKEGSEKERHNQQL--IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
E E LQ KER ++L +Q S + + + E + ++ + Q
Sbjct: 649 VKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQ 708
Query: 1556 SLRVELKAYEKLDEEHRRLRDG-------DKYPMESDNSFDLFDSSQAVTPKSVSETPPL 1608
L V LK E+ EE ++ D DK +E N + K +SE +
Sbjct: 709 HLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLE--NMMQRHEEEAHEKGKILSEQKAM 766
Query: 1609 SGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRL 1668
N DS ++L L+ +N ++ E ++ ++ Q Q+
Sbjct: 767 I-NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRN-------MKAQEEMISELRQ-QKF 817
Query: 1669 LAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPE 1728
E EA + +E L K + K L E RL+ VSL
Sbjct: 818 YLETQAGKLEAQNRKLEE---------QLEKISHQDHSDKNRLLELETRLR---EVSLE- 864
Query: 1729 DGQCPLHCEQIGEMKAEVTKLHKKLFEQEKK---LQNTMKLLQLSKRQEKVIFDQ 1780
H EQ E+K ++T+L L E+E + LQ L+ RQ K ++
Sbjct: 865 ------HEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEE 913
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 96.7 bits (239), Expect = 2e-19
Identities = 117/564 (20%), Positives = 247/564 (43%), Gaps = 57/564 (10%)
Query: 90 QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEI-QRVK-E 147
Q+ E K EL++ + L+ + E L ES ++ +E +R++ E
Sbjct: 1264 QQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAE 1323
Query: 148 DARKKVQQVEDLLTKRILLLEKDVTAAQ----AELEKAFAGTETEKALRLRLESKLSEM- 202
K++Q D L K++ ++E +V A+ AE+ + RL+ E + E+
Sbjct: 1324 KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVD 1383
Query: 203 --KKMHEGDLAMALVLDEK-----DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
KK + + L ++++ +R + +L+ + + +Q LK+ K Q + +
Sbjct: 1384 FTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKK-KCQRLTAELQDT 1442
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA--LEEDLREKEREIATEKKNS 313
L G ++ + E E Q E + E Q L+ + ++E+++ + S
Sbjct: 1443 KLHLEG-----QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 314 LK-----RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED 368
LK +D I G T + S E ++++++S+ K A+ AK ++ L+ + + +D
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV----KD 1553
Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKK--------ITQELSDLQQERERLEK 420
E L + L L E R+R++ K + + Q++ +++E
Sbjct: 1554 QEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1613
Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
LEE + +K K R+L ++ L ++VN R+ E R + L + L + + ++
Sbjct: 1614 QLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLD 1673
Query: 481 HLTESTNQKDVLLQKFNEKD-------LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533
HL S K + Q N+ + V + + EDL L+ + + K + ++
Sbjct: 1674 HLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEE- 1732
Query: 534 PGSKTIFSKEKKQ-----SSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF 588
+ +EK + D E++ +++KK + + L + IN+LQA+L +
Sbjct: 1733 --QLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ---INDLQAQLEEAN 1787
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQI 612
+++L++ + + Q+ + LE+ +
Sbjct: 1788 KEKQELQEKLQALQSQVEFLEQSM 1811
Score = 82.4 bits (202), Expect = 4e-15
Identities = 149/672 (22%), Positives = 270/672 (40%), Gaps = 128/672 (19%)
Query: 83 FLEERMQQEFHGPTEHIYKTNIELKVEVESL-KRELQEREQLLIKASKAVESLAEAGGSE 141
F ++R+QQEF E K+EVE KR+L+ R L +A E
Sbjct: 1384 FTKKRLQQEF------------EDKLEVEQQNKRQLERRLGDL-----------QADSEE 1420
Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLE-KDVTAAQAELEKAFAGTETEKALRLRLESKLS 200
QR + +KK Q++ L L LE + V + E ++ +E +A KL
Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480
Query: 201 EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
K E D+ +A LK L+ K+ I ++ + +++SS E +
Sbjct: 1481 REKLQREKDMLLAEAF--------SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 261 GLCAAPREEKE-RETEAAQMEHQKERNSFEERIQALEE-DLR---EKEREIATEKKNSLK 315
+ + +K+ R+ EA + ++E + IQ LE+ LR E ER T K
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592
Query: 316 RDKAIQGLTMALKSKEKKVE-ELNSEIEKLSAAFAKAREALQKAQT-------QEFQGSE 367
RD+ ++ + + K K++E +L E E + RE K T ++F+ +
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652
Query: 368 DYETALSGKEAL--SAALRSQNLTKSTENHRLRRSIKKITQELSDLQ-------QERERL 418
L +AL A L +L S + +R I ++ +L + + + R+ +
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPS---KREIAQLKNQLEESEFTCAAAVKARKAM 1709
Query: 419 EKDLEEAH-------REKSKGDCTIRDLRNEVEKLRNEVNEREKAME---NRYKSLLSES 468
E ++E+ H + K+ + + L+ E +++N + E ++ M ++K+ ++++
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769
Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFN--EKDLEVIQQNCYLMAAEDLELRSEGLITE 526
++ L + L E+ +K L +K + +E ++Q+ M + L R E I E
Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---MVDKSLVSRQEAKIRE 1826
Query: 527 KCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNK 586
+T E+ Q E L LK+ + K +E D +
Sbjct: 1827 ---------LETRLEFERTQVKRLESLASRLKENME------KLTEERD---------QR 1862
Query: 587 IFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVE 646
I A ++ EQ+ + LR T +E++ E+ R+E E+
Sbjct: 1863 IAAENREKEQNKRLQRQLRDT-KEEMGELARKEAEASR---------------------- 1899
Query: 647 HFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLAS 706
+ EL+ + L + L D + K I DL D + S E +L+ S
Sbjct: 1900 --KKHELEMDLESLEAANQSLQADLKLAFKRIGDLQA------AIEDEMESDENEDLINS 1951
Query: 707 KEDEDTIKIGED 718
+ D D ED
Sbjct: 1952 EGDSDVDSELED 1963
Score = 63.2 bits (152), Expect = 2e-09
Identities = 84/436 (19%), Positives = 183/436 (41%), Gaps = 41/436 (9%)
Query: 267 REEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMA 326
++E+ ++ + + +KERN LE + E E+ E+ + + T
Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAE 1318
Query: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKA---QTQEFQGSEDYETALSGKEAL--SA 381
EK+++EL ++ + L + +A + E G D + A G+ L
Sbjct: 1319 RLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA-GGEWRLKYER 1377
Query: 382 ALRSQNLTKSTENHRL-------RRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDC 434
A+R + TK +++ +++ + L DLQ + E ++ L++ ++ +
Sbjct: 1378 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA 1437
Query: 435 TIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLL- 493
++D + +E + +E EK + R+ S LS+++++ ++ + L +KD+LL
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEK-KQRRFDSELSQAHEEAQREKLQREKL---QREKDMLLA 1493
Query: 494 ------QKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
Q+ EKD+++ + LE + + S Q + +K KKQ
Sbjct: 1494 EAFSLKQQLEEKDMDIAG---FTQKVVSLEAELQDI------SSQESKDEASLAKVKKQL 1544
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQ------ESDSINNLQAELNKIFALRKQLEQDVLSY 601
D E ++ ++E D ++ L+ E + Q ++ + +++E+ S
Sbjct: 1545 RDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSC 1604
Query: 602 QNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLI 661
Q K +E Q+ E +++ + L+ ++ NR E S++ L+K +
Sbjct: 1605 QKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE--SEKRLRKDLKRTK 1662
Query: 662 QLVKELYTDNQHLKKT 677
L+ + HLK +
Sbjct: 1663 ALLADAQLMLDHLKNS 1678
Score = 52.0 bits (123), Expect = 5e-06
Identities = 123/666 (18%), Positives = 256/666 (38%), Gaps = 135/666 (20%)
Query: 953 RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPP 1012
+L Q+ QL+ ++ +LQ + +E + +QL +K A ++ T L+ +
Sbjct: 1396 KLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD------TKLHLEGQ 1449
Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDV 1072
++ +++ S + + + Q+ + + ++ + + +E D+
Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDI 1509
Query: 1073 LSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQ 1132
T L ++ Q + S D++ + L+ K+ D E EL+ I
Sbjct: 1510 AGFTQKVVSLEAELQDIS--SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567
Query: 1133 LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPE 1192
L+ +A + + E + SK D EE+ + + +K +++ L E
Sbjct: 1568 LE------QAKLRLEMEMERMRQTHSKEMESRD-EEVEEARQSCQKKLKQMEV--QLEEE 1618
Query: 1193 MIDSRVLENLKQQLE---------------EQEYKLQKEQNLNMQLFSEIHNLQNKFRDL 1237
D + + K++LE E E +L+K+ L ++ + + ++
Sbjct: 1619 YEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678
Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEEL-LQASDVDYCVAE 1296
+P + RE++ + Q+++ C + + M E+L LQ D+
Sbjct: 1679 APSK---------REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT- 1728
Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSAS 1356
+EQL++ +NE+ R+EED L+
Sbjct: 1729 ALEEQLSRL--------------------QREKNEIQNRLEEDQEDMNELM--------- 1759
Query: 1357 HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTN 1416
+K V S+DL +I L+ +LEE+ K
Sbjct: 1760 ------------------------KKHKAAVAQASRDLA-----QINDLQAQLEEANKEK 1790
Query: 1417 EKLRKQLERQGS--EFVQGST---SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSR 1471
++L+++L+ S EF++ S S+ + L + + F R Q + L ++ +
Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKE 1850
Query: 1472 DKQK---ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRC 1528
+ +K E D+ + +R+ + LQR+ KEE L ++ +E R +L ++
Sbjct: 1851 NMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDL-- 1908
Query: 1529 SGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELK-AYEKLDEEHRRLRDGDKYPMESDNS 1587
+ L + N QSL+ +LK A++++ + + D MESD +
Sbjct: 1909 ---------------ESLEAAN----QSLQADLKLAFKRIGDLQAAIED----EMESDEN 1945
Query: 1588 FDLFDS 1593
DL +S
Sbjct: 1946 EDLINS 1951
Score = 47.0 bits (110), Expect = 2e-04
Identities = 68/319 (21%), Positives = 149/319 (46%), Gaps = 32/319 (10%)
Query: 400 SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMEN 459
S ++I + ++QQ R +LEK A +E+++ L + + +L +E+ + E+
Sbjct: 1252 SEEQIRNKDEEIQQLRSKLEK----AEKERNELRLNSDRLESRISELTSELTDERNTGES 1307
Query: 460 RYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR 519
+ L +E+ ++L + K + E Q D L ++ ++EV++ A + E+
Sbjct: 1308 ASQLLDAETAERLRAE----KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVD 1363
Query: 520 SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINN 579
+ E + + F+K++ Q ++E+ ++V ++ + + LQ +DS +
Sbjct: 1364 DDDAGGEWRLKYERAVREVDFTKKRLQ-QEFEDKLEVEQQNKRQLERRLGDLQ-ADSEES 1421
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEE 639
+A + L+K+ ++ Q+ + LE Q ++R E E D S LS EE
Sbjct: 1422 QRA----LQQLKKKCQRLTAELQDTKLHLEGQ--QVRNHELEKKQRRFD--SELSQAHEE 1473
Query: 640 NNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699
R E +E+L+++ L+ E ++ Q L++ D++ GF ++ S E
Sbjct: 1474 AQR---EKLQREKLQREKD---MLLAEAFSLKQQLEEKDMDIA-------GFTQKVVSLE 1520
Query: 700 -QTELLASKEDEDTIKIGE 717
+ + ++S+E +D + +
Sbjct: 1521 AELQDISSQESKDEASLAK 1539
Score = 45.4 bits (106), Expect = 5e-04
Identities = 86/421 (20%), Positives = 164/421 (38%), Gaps = 59/421 (14%)
Query: 1399 IQEIRTLRKRL----EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSS---LTSE 1451
++E+ +KRL E+ ++ ++ ++QLER+ + S + +L LT+E
Sbjct: 1379 VREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAE 1438
Query: 1452 IHFLR---KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERL 1508
+ + + Q N L K R E + E R+ + E LQRE + E L
Sbjct: 1439 LQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSL 1498
Query: 1509 QKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYE--- 1565
+++ EK+ Q+V EL + + + L++ K L+ L ++K E
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEEL 1558
Query: 1566 ---------------KLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSG 1610
+L+ E R+R MES + ++ ++ Q+ K L
Sbjct: 1559 DEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE-EVEEARQSCQKKLKQMEVQLEE 1617
Query: 1611 NDTDSLSC------DSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL---LKQ 1661
D G AT + V+R K+ + L+ D + + LK
Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKN 1677
Query: 1662 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKF---VSSVSTAKLTLEEAYRRL 1718
+ +R +A++ Q +E+ + + + + + + ++ AK LEE RL
Sbjct: 1678 SAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRL 1737
Query: 1719 ---KLLWRVSLPED---------------GQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1760
K + L ED Q QI +++A++ + +K+ E ++KL
Sbjct: 1738 QREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKL 1797
Query: 1761 Q 1761
Q
Sbjct: 1798 Q 1798
Score = 37.0 bits (84), Expect = 0.17
Identities = 43/197 (21%), Positives = 92/197 (46%), Gaps = 26/197 (13%)
Query: 1391 SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450
S++ + +EI+ LR +LE++ K +LR +R S SEL S LT
Sbjct: 1252 SEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRI-----------SELTSELTD 1300
Query: 1451 EIHFLRKQNQALNAMLI------KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504
E + +Q L+A K ++ Q + D L++ + + + +E ++ E
Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM--EVMEMEVMEARLIRAAEI 1358
Query: 1505 NERLQKE--GSEKERHNQQLIQEVRCSGQELSR-VQEEVKLRQQLLSQNDKLLQSLRVE- 1560
N + + G E ++ ++EV + + L + ++++++ QQ Q ++ L L+ +
Sbjct: 1359 NGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADS 1418
Query: 1561 ---LKAYEKLDEEHRRL 1574
+A ++L ++ +RL
Sbjct: 1419 EESQRALQQLKKKCQRL 1435
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,118,131
Number of Sequences: 37866
Number of extensions: 3167238
Number of successful extensions: 33720
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 448
Number of HSP's successfully gapped in prelim test: 1340
Number of HSP's that attempted gapping in prelim test: 13783
Number of HSP's gapped (non-prelim): 10687
length of query: 1814
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1697
effective length of database: 13,817,196
effective search space: 23447781612
effective search space used: 23447781612
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.