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Search of human proteins with 58535451
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|58535451 CDK5 regulatory subunit associated protein 2
isoform a [Homo sapiens]
(1893 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 3684 0.0
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 3211 0.0
gi|50658069 phosphodiesterase 4D interacting protein isoform 2 [... 226 2e-58
gi|157311604 phosphodiesterase 4D interacting protein isoform 1 ... 226 2e-58
gi|71061468 centromere protein E [Homo sapiens] 142 2e-33
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 131 5e-30
gi|50658075 phosphodiesterase 4D interacting protein isoform 3 [... 127 8e-29
gi|50658077 phosphodiesterase 4D interacting protein isoform 4 [... 120 2e-26
gi|55770834 centromere protein F [Homo sapiens] 120 2e-26
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 117 8e-26
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 116 2e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 116 2e-25
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 115 4e-25
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 113 2e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 110 1e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 110 1e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 110 1e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 110 1e-23
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 110 1e-23
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 107 1e-22
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 106 2e-22
gi|31982906 cingulin-like 1 [Homo sapiens] 105 5e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 103 1e-21
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 103 2e-21
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 102 4e-21
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 99 5e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 98 7e-20
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 98 7e-20
gi|32698688 citron [Homo sapiens] 97 2e-19
gi|42794779 myosin 18A isoform b [Homo sapiens] 97 2e-19
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 3684 bits (9553), Expect = 0.0
Identities = 1893/1893 (100%), Positives = 1893/1893 (100%)
Query: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
Sbjct: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
Sbjct: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
Query: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
Sbjct: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
Query: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
Sbjct: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
Sbjct: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
Sbjct: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
Sbjct: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
Sbjct: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
Sbjct: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
Sbjct: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
Query: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
Sbjct: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
Query: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
Sbjct: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
Query: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
Sbjct: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
Query: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
Sbjct: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
Query: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
Sbjct: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
Sbjct: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
Sbjct: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
Sbjct: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
Sbjct: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
Sbjct: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS
Sbjct: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
Query: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS
Sbjct: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
Query: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE
Sbjct: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
Query: 1561 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK
Sbjct: 1561 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
Query: 1621 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS 1680
EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS
Sbjct: 1621 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS 1680
Query: 1681 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ 1740
VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ
Sbjct: 1681 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQ 1740
Query: 1741 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL 1800
ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL
Sbjct: 1741 ISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLL 1800
Query: 1801 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL 1860
WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL
Sbjct: 1801 WRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQL 1860
Query: 1861 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1893
VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Sbjct: 1861 VVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1893
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 3211 bits (8324), Expect = 0.0
Identities = 1689/1894 (89%), Positives = 1732/1894 (91%), Gaps = 81/1894 (4%)
Query: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
Sbjct: 1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM 60
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
Sbjct: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
Sbjct: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
Sbjct: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
Sbjct: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR 300
Query: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
Sbjct: 301 EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT 360
Query: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
Sbjct: 361 QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK 420
Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
Sbjct: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
Sbjct: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
Sbjct: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL
Sbjct: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE
Sbjct: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL
Sbjct: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
Query: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN
Sbjct: 781 FNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN 840
Query: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN
Sbjct: 841 SFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPIN 900
Query: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV
Sbjct: 901 TALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEV 960
Query: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS
Sbjct: 961 VTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
Query: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT
Sbjct: 1021 PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVAT 1080
Query: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS
Sbjct: 1081 YLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCS 1140
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE
Sbjct: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI
Sbjct: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK
Sbjct: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET
Sbjct: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
EKTSVMVNSFSQDLLMEHIQEIRT LRK+LE
Sbjct: 1381 EKTSVMVNSFSQDLLMEHIQEIRT--------------LRKRLEE--------------- 1411
Query: 1441 GSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
S T+E LRKQ + + ++GS +L SL T + L+++ +
Sbjct: 1412 -----SIKTNEK--LRKQLERQGSEFVQGSTSIFASGSELHSSL---TSEIHFLRKQNQA 1461
Query: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
+ N L K +K++ N +L + + L +Q E
Sbjct: 1462 L---NAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE--------------------- 1497
Query: 1561 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
Y + EE+ RL++ +G + R L+ E++ +L R E + +L+
Sbjct: 1498 ---YASVKEENERLQK------EGSEKERHNQQLIQEVRCSGQELSRVQE-----EVKLR 1543
Query: 1621 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDK-HDGDKYPMESDNSFDLFDSSQAVTPK 1679
+QL +K + +L V+ + ++ + + DGDKYPMESDNSFDLFDSSQAVTPK
Sbjct: 1544 QQLLSQNDKLLQ---SLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPK 1600
Query: 1680 SVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLK 1739
SVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLK
Sbjct: 1601 SVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLK 1660
Query: 1740 QISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL 1799
QISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL
Sbjct: 1661 QISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL 1720
Query: 1800 LWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQ 1859
LWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQ
Sbjct: 1721 LWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQ 1780
Query: 1860 LVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1893
LVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Sbjct: 1781 LVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS 1814
>gi|50658069 phosphodiesterase 4D interacting protein isoform 2
[Homo sapiens]
Length = 969
Score = 226 bits (575), Expect = 2e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
Query: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
Query: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
Score = 72.4 bits (176), Expect = 4e-12
Identities = 143/679 (21%), Positives = 281/679 (41%), Gaps = 125/679 (18%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
Query: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
Query: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
Query: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
Query: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
Query: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
Query: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCS 529
E I+ L +S + ++ Q EK ++ ++++N L A L S+ I+ + +
Sbjct: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIF 588
P G K+ Q S +Q+ +D T L + +E SI + +L+ +
Sbjct: 702 EVTPTG---CLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVA 749
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
L K+L +E++ + ++E ES S S +++ EE QV+
Sbjct: 750 GLEKEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAA 795
Query: 649 SQEELKKKVSDLIQLVKEL 667
E L + + L+K+L
Sbjct: 796 DMESLTRNIQIKEDLIKDL 814
Score = 50.1 bits (118), Expect = 2e-05
Identities = 104/504 (20%), Positives = 198/504 (39%), Gaps = 79/504 (15%)
Query: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
Query: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
Query: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
Query: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
L + QK +R ES +K S +H Q ++++
Sbjct: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ---SLRVE 1560
E LQ + + + E+R Q + + + ++QLL + +LLQ +
Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
Query: 1561 LKAYEKLDEEHRR--------LREASGEGWKG-QDPFRDLHSLLMEIQALRLQLERSIET 1611
L+A E L E+ R+ L A E + ++ ++L L + ++ LER +
Sbjct: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 526
Query: 1612 SS----TLQSRLKEQLARGAEKAQ 1631
S T+QS A+G E Q
Sbjct: 527 LSSNEATMQSMESLLRAKGLEVEQ 550
Score = 40.4 bits (93), Expect = 0.017
Identities = 112/521 (21%), Positives = 206/521 (39%), Gaps = 94/521 (18%)
Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
+ E+ + + ++ E E S + QDLL
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Query: 1555 QSLRVEL------KAYEKLDEEHRRLRE--ASGEGWKGQDPFRDLHSLLMEIQAL---RL 1603
+ L+++L A E+L +E LRE AS E + LL+ ++ L R
Sbjct: 812 KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 871
Query: 1604 QLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSI 1644
+L +++ L S L + A ++ L + ++ +
Sbjct: 872 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 912
>gi|157311604 phosphodiesterase 4D interacting protein isoform 1
[Homo sapiens]
Length = 2346
Score = 226 bits (575), Expect = 2e-58
Identities = 188/641 (29%), Positives = 322/641 (50%), Gaps = 36/641 (5%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE---GDLA----MALVLDEKDRLIEELKLSLKSK 233
A E EK L L KL + K E GD L ++D+ IEEL SL ++
Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQ 185
Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS----FE 289
E L++ L EK Q+ E +S E++ + ++++ + + Q +S +
Sbjct: 186 ERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQ 245
Query: 290 ERIQ-------ALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
E+IQ L+E L E E+ +++S K+D IQ L LKS+E++ EEL IE
Sbjct: 246 EKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIE 305
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
+ AK RE L ++Q + SE T+ + ++ L+S E +L+R ++
Sbjct: 306 GQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQQQVALLDLQSALFCSQLEIQKLQRVVR 363
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
+ ++L+D +Q + +E E+ ++K ++LR +++L+ E+ + + + +
Sbjct: 364 QKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQL----R 419
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+ +E ++ QEQ I+HL S + K+ LLQ+F E + L A E L +
Sbjct: 420 AWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQ 479
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
I +K + + + + E+K+ + + V +++ D+ + L++ S N
Sbjct: 480 RIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDL-----ERLRDVLSSNEATM 534
Query: 583 ELNKIFALRKQLEQDVLS--YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
+ + K LE + LS QNL+ EE ++ R ++E S+ L L +
Sbjct: 535 QSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQ----LQTSLHDR 590
Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
N+ +VE S L K ++ +EL Q ++ + DL
Sbjct: 591 NK-EVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDL 630
Score = 204 bits (518), Expect = 9e-52
Identities = 170/523 (32%), Positives = 277/523 (52%), Gaps = 45/523 (8%)
Query: 1393 DLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG---STSIFASGSELHSSLT 1449
DLL EH+ EIR LR+RLEESI N++LR+QLE + + +G +++ ++ G E L
Sbjct: 1842 DLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLC 1901
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
+E LR+ N+ L A L SR+ +E + LRE+L L+ L++E K E ++L
Sbjct: 1902 NENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQKVERQQLL 1961
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDE 1569
++ EK++ +E + SR+Q ++ L QQ + +L +SL+ EL+ YE L
Sbjct: 1962 EDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEALYG 2021
Query: 1570 EHRRLREASGEGWKGQDPF-RDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAE 1628
++ +A Q P DL L+ E++ALR QLE+SI+ ++ L+ +L++QL GA
Sbjct: 2022 NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCLRLQLQQQLESGAG 2081
Query: 1629 KAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDL------FDSSQAVTPKSVS 1682
KA +L+ +++ P D G+K + D++ +S V P S S
Sbjct: 2082 KA-----SLSPSSIN-QNFPASTD--PGNKQLLLQDSAVSPPVRDVGMNSPALVFPSSAS 2133
Query: 1683 ETPPLSGNDTDSLSCDSG-----SSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL 1737
TP G++T ++ +G S TP +A+K+GRHV+G I+DY AL
Sbjct: 2134 STP---GSETPIINRANGLGLDTSPVMKTPPKLEGDATDGSFANKHGRHVIGHIDDYSAL 2190
Query: 1738 LKQISQGQRLLAEMDIQTQEAPSSTSQE------LGTKGPHPAPLSKFVSSVSTAKLTLE 1791
+QI++G+ L+ ++ + A S E LG+KG H + SS S LE
Sbjct: 2191 RQQIAEGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIH-----ELRSSTSALHHALE 2245
Query: 1792 EAYRRLKLLWRVSLPEDGQCPLHCEQIGE-MKAEVTKLHKKLFEQEKKLQNTMKLLQLSK 1850
E+ L + WR +LP P+ ++GE + E+ +L K+ +QE+ LQ+T + L+ +
Sbjct: 2246 ESASLLTMFWRAALPST-HIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNAN 2304
Query: 1851 RQ----EKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPS 1889
+Q E+ I QL TH +L+KAR NLE++ A P C+P+
Sbjct: 2305 QQKESMEQFIVSQLTRTHDVLKKARTNLEVKSLRALP--CTPA 2345
Score = 134 bits (336), Expect = 1e-30
Identities = 275/1354 (20%), Positives = 534/1354 (39%), Gaps = 188/1354 (13%)
Query: 107 KVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILL 166
++E++ L+R ++++E+ L A + V+ EA E ++ KE + K Q+
Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQ-FVEAAAHESEQQKEASWKHNQE----------- 399
Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226
L K + Q EL+ + LR K +E++ + + L K++L++E
Sbjct: 400 LRKALQQLQEELQNK------SQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEF 453
Query: 227 K----------LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
+ +L++ E L++ L++ A E + L +E ++
Sbjct: 454 RELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAV 513
Query: 277 AQMEHQKER-----NSFEERIQALEEDLREKEREI----ATEKKNSLKRDKAIQGLTMAL 327
+ +H ER +S E +Q++E LR K E+ T + +++ +
Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Query: 328 KSKEKKVEEL-------NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALS 380
K +E +++L N E+E LSA L K + + +E+ L KE +
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATL------LCKLGPGQSEIAEELCQRLQRKERML 627
Query: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
L S K H + I+ + Q +S +QE + + L +A E++ +R
Sbjct: 628 QDLLSDR-NKQVLEHEME--IQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYL 684
Query: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
+ L ++ + E L + + Q T T ++DV + + D
Sbjct: 685 GGRDSLMSQAPISNQQAEVTPTGCLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLGD 744
Query: 501 LEVIQ--QNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKK----QSSDYEELI 554
L+ + + A E+LEL ++ E+ S + +++ + +++ Q++D E L
Sbjct: 745 LDTVAGLEKELSNAKEELELMAK---KERESQMELSALQSMMAVQEEELQVQAADMESLT 801
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI-- 612
+ ++ ++D+ L L + + I ++ ++ LR+++ Q + +Q+
Sbjct: 802 RNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLL 861
Query: 613 ---SEIRRREEESFSLYSDQTSYLSICL--------EENNRFQVEHFSQEELKKKVSDLI 661
+ R + +L +++ Y S+ E + QVE + L+ ++ ++
Sbjct: 862 MLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQVLRSRLEEV- 920
Query: 662 QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELL----ASKEDEDTIKIGE 717
L + L N+ + L+ +G G STE T+ + A + +K+
Sbjct: 921 -LGRSLERLNR-----LETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVAL 974
Query: 718 DDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHT---------ESKISDCDGAHAPGCL 768
+ + + Q+ S C + H E + ++ + +
Sbjct: 975 EKSLATVETQNPSFSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEELKELKAQI 1034
Query: 769 EEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHL-DGKTEKTP 827
EE F ++ + + N +L LE+ EL +E GE + DG +
Sbjct: 1035 EEAGFSSV-SHIRNTMLSLCLENA--------EL---------KEQMGEAMSDGWEIEED 1076
Query: 828 KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKH 887
K+KGE++ V+T + E L E + ++ LK+A + L+
Sbjct: 1077 KEKGEVM--VETVVTKEGLSESSLQAEFRKLQGK------LKNAHNIINLLKEQLVLSSK 1128
Query: 888 EATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRS 947
E + E ++ + E L G PG E + P S
Sbjct: 1129 EGNSKLTPELLVHLTSTIERINTELVGSPGKHQH--------QEEGNVTVRPFPRPQSLD 1180
Query: 948 LGNMYRLPATQ------------EVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAV 995
LG + + A Q + L L+ +L + K + L +KL+L+EA
Sbjct: 1181 LGATFTVDAHQLDNQSQPRDPGPQSAFSLPGSTQHLRSQLSQCKQRYQDLQEKLLLSEAT 1240
Query: 996 MEGRPTP---DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE 1052
+ + + +L + V + + + + + + E + ++ S E +
Sbjct: 1241 VFAQANELEKYRVMLTGESLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEH 1300
Query: 1053 ICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY- 1111
+ + C E + L+S S+ + +G + + +E
Sbjct: 1301 NSLKEMVLMEGLCSEQGRR-------GSTLASSSERKPLENQLGKQEEFRVYGKSENILV 1353
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE--------GAQDGLSKPKNG 1163
L++ I DL+ +L+ I L+ + E G +G S P +
Sbjct: 1354 LRKDIKDLKAQLQNANKVIQNLKSRVRSLSVTSDYSSSLERPWKLRAVGTLEG-SSPHSV 1412
Query: 1164 SDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQL 1223
D +E S Y +P + + LE+L Q++ + E +L K L +L
Sbjct: 1413 PDEDEGWLSDGTGAFY----------SPGLQAKKDLESLIQRVSQLEAQLPKN-GLEEKL 1461
Query: 1224 FSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEE 1283
E+ + P +YDSL+Q QARELS RQ+I++G GIC + +H +K+FE+
Sbjct: 1462 AEELRSAS------WPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFED 1515
Query: 1284 LLQASDVDYCVAEGFQEQLNQCAELLEKL-EKLFLNG-----KSVGVE---MNTQNELME 1334
LL+++D+DY + + F+EQL Q ++L E+L KL G+E + EL E
Sbjct: 1516 LLRSNDIDYYLGQSFREQLAQGSQLTERLTSKLSTKDHKSEKDQAGLEPLALRLSRELQE 1575
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKS 1368
+ + + L S PS+SHALSD S S
Sbjct: 1576 KEKVIEVLQAKLDARSLTPSSSHALSDSHRSPSS 1609
Score = 72.4 bits (176), Expect = 4e-12
Identities = 143/679 (21%), Positives = 281/679 (41%), Gaps = 125/679 (18%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--------TNIELKVEVESLKR 115
E + +L +E L ++ LEE E TE + K T I + +S
Sbjct: 186 ERLVEQLSREKQQL---LHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA 242
Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
ELQE+ Q +K ++ E++ +E ++K+ +++L ++ + + +
Sbjct: 243 ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNL--------KETLKSRE 294
Query: 176 AELEKAFAGTETEKALRLRLESKL--SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
E E+ + E + +L L S++ ++H + ++ + +L+ +L
Sbjct: 295 RETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCS 351
Query: 234 EALIQCL----KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
+ IQ L ++++ Q+A + V E A E E++ EA+ +Q+ R +
Sbjct: 352 QLEIQKLQRVVRQKERQLADAKQCVQFVE------AAAHESEQQKEASWKHNQELRKA-- 403
Query: 290 ERIQALEEDLREKEREIAT---EKKNSLK-RDKAIQGLTMALKSKEKKVEEL-------- 337
+Q L+E+L+ K +++ EK N ++ +++ IQ L +L KE+ ++E
Sbjct: 404 --LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRD 461
Query: 338 NSE---------IEKLSAAFAKAREALQKAQTQEFQGSEDYETALS-----------GKE 377
NS+ +EKL AL++A ++F E+ E L E
Sbjct: 462 NSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLE 521
Query: 378 ALSAALRSQNLTKSTENHRLRRS---IKKITQELSDLQQERERLEKDLEEAHREKS---- 430
L L S T + LR +++++ +LQ +E +E +E+
Sbjct: 522 RLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQ 581
Query: 431 KGDCTIRDLRNEVEKLR---------------NEVNEREKAMENRYKSLLSESNKKLHNQ 475
+ ++ D EVE L E+ +R + E + LLS+ NK++
Sbjct: 582 QLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEH 641
Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCS 529
E I+ L +S + ++ Q EK ++ ++++N L A L S+ I+ + +
Sbjct: 642 EMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQAPISNQQA 701
Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIF 588
P G K+ Q S +Q+ +D T L + +E SI + +L+ +
Sbjct: 702 EVTPTG---CLGKQTDQGS-----MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVA 749
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
L K+L +E++ + ++E ES S S +++ EE QV+
Sbjct: 750 GLEKEL-----------SNAKEELELMAKKERESQMELSALQSMMAVQEEE---LQVQAA 795
Query: 649 SQEELKKKVSDLIQLVKEL 667
E L + + L+K+L
Sbjct: 796 DMESLTRNIQIKEDLIKDL 814
Score = 50.1 bits (118), Expect = 2e-05
Identities = 104/504 (20%), Positives = 198/504 (39%), Gaps = 79/504 (15%)
Query: 1199 LENLKQQLEEQEYKLQKE----QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
+E+LK++L++++ L K +NLN Q +E+ Q + R L++++ + L
Sbjct: 55 VESLKRELQDKKQHLDKTWADVENLNSQNEAELRR-QFEERQQETEHVYELLENKIQLLQ 113
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
+ + K+ + E L+ ++ G Q + +Q E L + +K
Sbjct: 114 EESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDK 173
Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL---------PESPEPSASHALSDYETS 1365
+ + + Q L+E++ + HLL P + E L+ +ET+
Sbjct: 174 RI---EELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETT 230
Query: 1366 ------EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKL 1419
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L
Sbjct: 231 ITQQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNL 286
Query: 1420 RKQL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNA 1464
++ L ER+ E ++G A E LH S ++H + A L +
Sbjct: 287 KETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQS 346
Query: 1465 MLIKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKE 1503
L + QK +R ES +K S +H Q ++++
Sbjct: 347 ALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQ 406
Query: 1504 ENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ---SLRVE 1560
E LQ + + + E+R Q + + + ++QLL + +LLQ +
Sbjct: 407 LQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKT 466
Query: 1561 LKAYEKLDEEHRR--------LREASGEGWKG-QDPFRDLHSLLMEIQALRLQLERSIET 1611
L+A E L E+ R+ L A E + ++ ++L L + ++ LER +
Sbjct: 467 LEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDV 526
Query: 1612 SS----TLQSRLKEQLARGAEKAQ 1631
S T+QS A+G E Q
Sbjct: 527 LSSNEATMQSMESLLRAKGLEVEQ 550
Score = 45.4 bits (106), Expect = 5e-04
Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 37/236 (15%)
Query: 379 LSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRD 438
L++ R + T + + L SI ++ E L+++ RL+ L RE S+
Sbjct: 1876 LTSTARGRGSTSNFYSQGLE-SIPQLCNENRVLREDNRRLQAQLSHVSREHSQ------- 1927
Query: 439 LRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
E E LR E + +R S L E K+L +Q+ + L E +K + F E
Sbjct: 1928 ---ETESLR------EALLSSR--SHLQELEKELEHQKVERQQLLEDLREKQQEVLHFRE 1976
Query: 499 KDLEVIQQNCYLMAAEDLELRSE-GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVL 557
+ L +Q+N D L+ + L+ ++C +Q +F + + YE L
Sbjct: 1977 ERLS-LQEN-------DSRLQHKLVLLQQQCEEKQQ-----LFESLQSELQIYEALYGNS 2023
Query: 558 KKEQDIYT-HLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
KK Y+ + S +++L AE+ ALR QLEQ + LR L++Q+
Sbjct: 2024 KKGLKAYSLDACHQIPLSSDLSHLVAEVR---ALRGQLEQSIQGNNCLRLQLQQQL 2076
Score = 40.4 bits (93), Expect = 0.017
Identities = 112/521 (21%), Positives = 206/521 (39%), Gaps = 94/521 (18%)
Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 411 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 468
Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 469 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 513
Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 514 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 573
Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
+ E+ + + ++ E E S + QDLL
Sbjct: 574 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 633
Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 634 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 693
Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 694 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 751
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 752 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 811
Query: 1555 QSLRVEL------KAYEKLDEEHRRLRE--ASGEGWKGQDPFRDLHSLLMEIQAL---RL 1603
+ L+++L A E+L +E LRE AS E + LL+ ++ L R
Sbjct: 812 KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 871
Query: 1604 QLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSI 1644
+L +++ L S L + A ++ L + ++ +
Sbjct: 872 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 912
Score = 35.4 bits (80), Expect = 0.53
Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 14/133 (10%)
Query: 278 QMEHQKERNSFEERIQALEEDLREKEREI---ATEKKNSLKRDKAIQG----LTMALKSK 330
++EHQK Q L EDLREK++E+ E+ + + D +Q L + K
Sbjct: 1949 ELEHQKVER------QQLLEDLREKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEK 2002
Query: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
++ E L SE++ A + +++ L KA + + + LS A ALR Q
Sbjct: 2003 QQLFESLQSELQIYEALYGNSKKGL-KAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQS 2061
Query: 391 STENHRLRRSIKK 403
N+ LR +++
Sbjct: 2062 IQGNNCLRLQLQQ 2074
Score = 34.7 bits (78), Expect = 0.91
Identities = 60/282 (21%), Positives = 117/282 (41%), Gaps = 35/282 (12%)
Query: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAP--------- 266
L E L + L+ S+ + L + L+ + A + S+ +GL + P
Sbjct: 1848 LGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNENRVL 1907
Query: 267 REEKER---ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323
RE+ R + EH +E S E + + L+E E+E+ +K ++R + ++ L
Sbjct: 1908 REDNRRLQAQLSHVSREHSQETESLREALLSSRSHLQELEKELEHQK---VERQQLLEDL 1964
Query: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAR-----EALQKAQTQEFQGSEDYETALSGKEA 378
+EK+ E L+ E+LS +R LQ+ ++ Q E ++ L EA
Sbjct: 1965 ------REKQQEVLHFREERLSLQENDSRLQHKLVLLQQQCEEKQQLFESLQSELQIYEA 2018
Query: 379 LSAALRSQNLTKSTENHRLRRSIK-KITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437
L N K + + L + ++ +LS L E L LE++ + +C
Sbjct: 2019 LYG-----NSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQ---GNNCLRL 2070
Query: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
L+ ++E + + ++ + + NK+L Q+ +
Sbjct: 2071 QLQQQLESGAGKASLSPSSINQNFPASTDPGNKQLLLQDSAV 2112
Score = 33.5 bits (75), Expect = 2.0
Identities = 37/149 (24%), Positives = 69/149 (46%), Gaps = 16/149 (10%)
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD-QTSYLSIC-- 636
L+ L +I LR++LE+ + LR+ LE +++ R + + YS S +C
Sbjct: 1844 LEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTSNFYSQGLESIPQLCNE 1903
Query: 637 ---LEENNR---FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690
L E+NR Q+ H S+E ++ S L + L + HL++ +L +
Sbjct: 1904 NRVLREDNRRLQAQLSHVSREHSQETES----LREALLSSRSHLQELEKELEHQKVERQQ 1959
Query: 691 FPDRLASTEQTELLASKEDEDTIKIGEDD 719
+ L +Q E+L +E+ + + E+D
Sbjct: 1960 LLEDLREKQQ-EVLHFREER--LSLQEND 1985
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 142 bits (359), Expect = 2e-33
Identities = 329/1603 (20%), Positives = 645/1603 (40%), Gaps = 249/1603 (15%)
Query: 140 SEIQRVKEDARKKVQQVEDLLTKR----ILLLEKDVTAAQAELEKAFAGTETEKALRLRL 195
SE+ ++ D V E L T++ + L EK+ LE+ +T+K ++L
Sbjct: 498 SELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALER-----KTKKDQEMQL 552
Query: 196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
++S +K + + + ++L+ L SK ++ L+E++ Q+ E +
Sbjct: 553 IHEISNLKNL----------VKHAEVYNQDLENELSSK---VELLREKEDQIKKLQEYID 599
Query: 256 SGELRGL----------CAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKERE 305
S +L + P++ K+ +A + +R S R + LE L+EK +E
Sbjct: 600 SQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLE--LKEKMKE 657
Query: 306 IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQG 365
+AT K + + IQ L++K+K +L E++ K + ++
Sbjct: 658 LATTYK---QMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLC 714
Query: 366 SEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEA 425
+ + E ++ + + L K E + R + EL L E ERL K++++
Sbjct: 715 NLELEGKITDLQ--------KELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 426 HREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--------LSESNKKLHNQE- 476
E + + +E +KL +EV +E ++ + + ++SN K +QE
Sbjct: 767 SEE-------LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819
Query: 477 QVIKHLTESTNQKDVLLQKFNEK-DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPG 535
Q K L QK ++ + NE+ + E++ + A+ + L TE Q
Sbjct: 820 QNFKTLHMDFEQKYKMVLEENERMNQEIVNLS---KEAQKFDSSLGALKTELSYKTQELQ 876
Query: 536 SKTIFSKE--------KKQSSDYEELIQVLKKEQDIYTHL-------VKSL-QESDSINN 579
KT +E K+Q + + +Q +++E+ + T VK+L QE D +
Sbjct: 877 EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQ 936
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI----SEIRRREEESFSLYSDQTSYLS- 634
LQ L R QL+ D+ N+ +EQ+ +++ +E +L S + +S
Sbjct: 937 LQESLQ---IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
Query: 635 -ICLEENNRFQVEHFSQEELK-KKVSDL----IQLVKELYTDNQHLK--KTIFDLSCMGF 686
+ +EEN + F Q+ + K DL Q + DN+ ++ + IF L
Sbjct: 994 NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ--- 1050
Query: 687 QGNGFPDRLAST--EQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGC 744
+ N L S E+ +L ++ + I +E+ L D+ +Q + ++ +
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110
Query: 745 KNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLL 804
K G L T ++++ + EK+ L E + LL V E+
Sbjct: 1111 KEGELSRTCDRLAEVEEK------------------LKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 805 GQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVP 864
Q + E E L K + E + Q KL+ + VK+
Sbjct: 1153 MQKKINEIENLKNELKNKELTLEHMETERLELAQ-----------KLNENYEEVKSITKE 1201
Query: 865 KVGLKDASVQTVATEGDLLRF---KHEATR-EAWEEKPINTALSAEHRP---ENLHGVPG 917
+ LK+ ++ TE D LR + EAT + EE I EH+ E V
Sbjct: 1202 RKVLKELQ-KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Query: 918 WQAALLSLPGITNREAK-KSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELK 976
A +++ + K + +P+L + L N+ + TQE + +L ++L Q K
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL--ELLTEQSTTK 1318
Query: 977 EFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRD 1036
+ T + ++L L E E + K+L + + K IK V D
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQ-EEIKSLTKERDNL-----------KTIKEALEVKHD 1366
Query: 1037 KEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMG 1096
+ + ++ +I + ++ KE + S K ++ +
Sbjct: 1367 QLKEHIRETLAKIQESQSKQEQSLNM---KEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 1097 TDQSESINTS-NETEYLKQKIHDLETELEGYQNFIFQLQ--------KHSQCSEAIITVL 1147
S+ + S +E + + ++ DL+ E Q+ QL+ KH + E +
Sbjct: 1424 LGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAH 1483
Query: 1148 CGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLE 1207
C + ++ +++ + +E S++ + LE + +L+
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTI---------------------QKQLEAINDKLQ 1522
Query: 1208 EQEYKL-QKEQNLNMQLFSEIHNLQNKFRDLSPPR--YDSLVQSQARELSLQRQQIKDGH 1264
+ ++ +KE+ N++ SE+ N+ + R DS +QS ++ ++++
Sbjct: 1523 NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE-- 1580
Query: 1265 GICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ-CAELLEKLEKLFLNGKSVG 1323
S++ + MIK EE+ + + + +E + A++ E EK + K
Sbjct: 1581 -----SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635
Query: 1324 V---------------EMNTQNELMERIEEDNLTYQHLLPESPEP--SASHALSDYETSE 1366
V + TQ +E IE +N+ +L E+ E S + D + E
Sbjct: 1636 VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVE 1695
Query: 1367 KSF-FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425
++ RDQ ++N E + ++DL E +E++ + L+E +T +KLR +
Sbjct: 1696 ETLKVERDQLKENLRE-------TITRDL--EKQEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
+ +E + S L + LR + L +++Q+ DKLR +S
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHL--------KEQQETIDKLRGIVS 1798
Query: 1486 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ 1545
KT L ++Q++ ++ N +LQ++ E + + QLI + + +V E +L++Q
Sbjct: 1799 EKTDKLSNMQKD---LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 1546 LLSQNDKL----LQSLRVELKAYEKLDE------EHRRLREASGEGWKGQDPFRDLHSLL 1595
+ Q+ L +++L + K +E L+E E LR +D L L
Sbjct: 1856 IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD---QLKESL 1912
Query: 1596 MEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLA 1638
E +A L++++ ++T+ L KE + + EK E + ++
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS 1955
Score = 127 bits (319), Expect = 1e-28
Identities = 310/1627 (19%), Positives = 657/1627 (40%), Gaps = 208/1627 (12%)
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
+H N +L+ E+ S L+E+E + K + ++S +++ +K D ++ +
Sbjct: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS------QKLENIKMDLSYSLESI 617
Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK---KMHEGDLAM- 212
ED + L + + A A+ E AF +E L L+ K+ E+ K E D+ +
Sbjct: 618 EDPKQMKQTLFDAETVALDAKRESAFLRSEN-----LELKEKMKELATTYKQMENDIQLY 672
Query: 213 ALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER 272
L+ K ++ +L+ L+S I L P + + + EL G ++E +
Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV-PKDLLCNLELEGKITDLQKELNK 731
Query: 273 ETEAAQMEHQK-----ERNSFEERIQALEEDLREKERE--IATEKKNSLKRDKAIQGLTM 325
E E + ++ E S ++ L +++++K E I T +K+ L +
Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE-------- 783
Query: 326 ALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRS 385
+ KE +V+ L EI K A ++ K+ QEFQ + K +
Sbjct: 784 -VVHKESRVQGLLEEIGKTKDDLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMVLE--- 838
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
EN R+ QE+ +L +E ++ + L E S +++ EV++
Sbjct: 839 -------ENERMN-------QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 446 LRNEVNEREKAMENRYKSLLSESNKK---LHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
NE+ + ++ +ENR +L + +K +Q ++ + T +KD L Q +E
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 503 ---------------VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
+ Q A E L+ E + T K + + ++
Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGET 1004
Query: 548 SD-YEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA-------LRKQLEQDVL 599
D +++ + + K+QD+ ++L N + + KIF+ L++ LE +
Sbjct: 1005 KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIA 1064
Query: 600 SYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSD 659
+ L+ L+E I +EE L + I +E N + ++++
Sbjct: 1065 EKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE 1124
Query: 660 LIQLVKE----LYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKI 715
+ + +KE L Q L ++S M + N + + EL + + +++
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184
Query: 716 GEDDEINFLSDQHLQQSNEIMKDLSKG-----GCKNGYLRHTES---------KISDCDG 761
+ N+ + + + +++K+L K GY+R E+ KI+
Sbjct: 1185 AQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHL 1244
Query: 762 AHAPGCLEE--GAFINLLAPLFN----EKATLLLESRPDLLKVVRELLLGQLFLTEQEVS 815
++E + A + N EK+ L+ +L +ELL ++E + +
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQET 1304
Query: 816 GEHLDGKTEK------TPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVK----AGEVP 864
L+ TE+ T + E+ F + +E+K L+ E +K A EV
Sbjct: 1305 MNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364
Query: 865 KVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLS 924
LK+ +T+A + + K E + E+ T + +E + +ALL
Sbjct: 1365 HDQLKEHIRETLAKIQE-SQSKQEQSLNMKEKDNETTKIVSE-----MEQFKPKDSALLR 1418
Query: 925 LP----GITNR-EAKKSRLPILIKPSRSLGNMYRLPATQ-----EVVTQLQSQILELQGE 974
+ G++ R + + + K L + + ++ E + ++ ++ LE + E
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
Query: 975 LKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVW 1034
LK C K+ + + + + T T+ + Q+ E ++
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE---------IY 1529
Query: 1035 RDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENP-EDVLSPTSVATYLSSKSQPSAKVS 1093
+E + +Q S E+ ++ K++ + + S T +SQ ++
Sbjct: 1530 EKEEQFNIKQIS-EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 1094 VMGTDQSESINTS--NETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE 1151
+ ++ + + + E + LK+ ++ +++ Q +Q K + +E +C E
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET-QEKMCEIE 1647
Query: 1152 GAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR-VLENLKQQLEEQE 1210
++ K + E L Q+ + ++++ + + E D R V E LK + ++ +
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILH-ENLEEMRSVTKERDDLRSVEETLKVERDQLK 1706
Query: 1211 YKLQK--EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICV 1268
L++ ++L Q +I ++ K + + +V + E+S ++ +
Sbjct: 1707 ENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL-------- 1758
Query: 1269 ISRQHMNTMIKAFEELLQAS-DVDYCVAEGFQEQLNQCAELL-EKLEKLFLNGKSVGVEM 1326
+H N +KA + +Q + + + QE +++ ++ EK +KL K +
Sbjct: 1759 ---EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDL---E 1812
Query: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
N+ +L E+I+E L+ + K + QK+ +E E+
Sbjct: 1813 NSNAKLQEKIQELKANEHQLI-----------------TLKKDVNETQKKVSEMEQLKKQ 1855
Query: 1387 VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHS 1446
+ S L I+ + L ++L E+++ + + K ER V+ + + +L
Sbjct: 1856 IKDQSLTLSKLEIENL-NLAQKLHENLEEMKSVMK--ERDNLRRVEETLKL--ERDQLKE 1910
Query: 1447 SL-TSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
SL ++ L Q + A ++ S++ ++ DKLRE +S KT+ + +Q++ K+E
Sbjct: 1911 SLQETKARDLEIQQELKTARML--SKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE- 1967
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE-LKAY 1564
LQK+ E ++ QL++ ++ E +L++Q +QN +QS+R++ +
Sbjct: 1968 --LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN-LSMQSVRMDNFQLT 2024
Query: 1565 EKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLA 1624
+KL E +R + K +D R + ++L+++ ++ I T L+E +A
Sbjct: 2025 KKLHESLEEIRIVA----KERDELRRIK------ESLKMERDQFIAT-------LREMIA 2067
Query: 1625 RGAEKAQ 1631
R + Q
Sbjct: 2068 RDRQNHQ 2074
Score = 104 bits (259), Expect = 9e-22
Identities = 345/1731 (19%), Positives = 686/1731 (39%), Gaps = 270/1731 (15%)
Query: 56 RARNMKDFENQITELKK--ENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESL 113
+ R +++ N++ +LK+ EN + L+ E+ + E T KT + K +++ L
Sbjct: 878 KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 114 KRELQ-EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK------RILL 166
+ LQ ER+QL V + +++ E ++ + + L +K R L
Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQETINTLKSKISEEVSRNLH 996
Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHE---GDLAMALVLDEKDRLI 223
+E++ + E ++ G + ++ L + L+ K +E + ++ EK+ L
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 224 EELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH-- 281
+ L+ + KE L LKE +M ++ ELR L +K++E A + H
Sbjct: 1057 QMLESVIAEKEQLKTDLKEN-IEMTIENQE----ELRLL--GDELKKQQEIVAQEKNHAI 1109
Query: 282 --QKERNSFEERIQALEEDLREKEREIATEKKNSL----------KRDKAIQGLTMALKS 329
+ E + +R+ +EE L+EK +++ +++ L K+ I+ L LK+
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKN 1169
Query: 330 KEKKVEELNSEIEKLSA----------AFAKAREALQKAQTQEFQGSEDY---------E 370
KE +E + +E +L+ + K R+ L++ Q + F+ D+
Sbjct: 1170 KELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ-KSFETERDHLRGYIREIEA 1228
Query: 371 TALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQEL---SDLQQERERLEKDLEEAHR 427
T L KE L A + T + LRRS+ + T ++ DL++ +L++++ H
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDE-LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287
Query: 428 EKS-----KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHL 482
E+ K ++ NE+E L + ++ R + N+K ++ IK L
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 483 T----------ESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQ- 531
T E+ K L++ + L IQ++ + L ++ + T K S+
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES-QSKQEQSLNMKEKDNETTKIVSEM 1406
Query: 532 ---QPPGSKTI------FSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
+P S + K+ ++E+ V K++ D+ ++ + +S+S + L+
Sbjct: 1407 EQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL--QRLQEVLQSES-DQLKE 1463
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR-RREEESFSLYSDQTSYLSICLEENN 641
+ +I A + E+++ K EE I+E+R E+ + + Q +I + N
Sbjct: 1464 NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN 1523
Query: 642 RFQVEHFSQEELK-KKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
+ Q + +E+ K++S++ + V EL +H K L + + +RL +++
Sbjct: 1524 KIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQE 1583
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKN-GYLRHT---ESKI 756
+ KE E+ ++ E +I DQ + + EI+ + + K +L+ T E++
Sbjct: 1584 EIQIMIKEKEEMKRVQEALQIE--RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641
Query: 757 SDCDGAHAPGCLE---------EGAFINLLAPLFN--EKATLLLESRPDL------LKVV 799
C+ H E E I L L E+ + + R DL LKV
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 800 RELLLGQLFLT-------EQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLS 852
R+ L L T ++E+ H+ K + K + +TN S +L+ S
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENL 912
+A +KA +D +Q + LR H +E E + L
Sbjct: 1762 NDA--LKA--------QDLKIQ------EELRIAHMHLKEQQE------------TIDKL 1793
Query: 913 HGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQ 972
G+ + LS ++ + S + K N ++L ++ V + Q ++ E++
Sbjct: 1794 RGIVSEKTDKLS---NMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 973 GELKEFK----TCNK----------QLHQKLILAEAVMEGRPT---PDKTLLNAQPPVGA 1015
K+ K T +K +LH+ L ++VM+ R ++TL + +
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910
Query: 1016 AYQDSPGE----QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
+ Q++ Q+ +KT + ++ + D+ R + I D L K+
Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE--- 1967
Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTS----NETEYLKQKIHDLETELEGYQ 1127
L K Q K + E +N S NE E LK++ ++ +
Sbjct: 1968 ----------LQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017
Query: 1128 NFIFQLQK--HSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF-SSLHQVRYVKHVK 1184
FQL K H E I +D L + K E F ++L ++ + +
Sbjct: 2018 MDNFQLTKKLHESLEEIRIVA-----KERDELRRIKESLKMERDQFIATLREM--IARDR 2070
Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
+ PE R+L + +Q L E L+++ + +L + + + L+ D
Sbjct: 2071 QNHQVKPE---KRLLSDGQQHLTE---SLREKCSRIKELLKRYSEMDDHYECLNRLSLDL 2124
Query: 1245 LVQSQ-ARELSLQRQQIKDGHGICVISRQHMNTMIKA-------FEELLQASDVDYCVAE 1296
+ + +ELS+ ++K + + +H+ + A F +++
Sbjct: 2125 EKEIEFQKELSM---RVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVT 2181
Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSAS 1356
+E+ + E + K E F++ E+ Q EL+ +I QHL + P S
Sbjct: 2182 KIKEEQH---ESINKFEMDFID------EVEKQKELLIKI-------QHLQQDCDVP--S 2223
Query: 1357 HALSDYETSEK---------SFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRK 1407
L D + ++ FS + +TE V+ N +E R +
Sbjct: 2224 RELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE 2283
Query: 1408 RLEESI-KTNEKLRK----------QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR 1456
+L+ I K N+++ + + + +EF + S +I + SL + L
Sbjct: 2284 KLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF 2343
Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSL--EHLQREYASVKEENERLQKEGSE 1514
K Q L L G++ D ++ + L E ++ S+ E E
Sbjct: 2344 KNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKE----SAMH 2399
Query: 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL----KAY-EKLDE 1569
KE ++ +E+ + ++++Q +V + L + + +Q L+ ++ K Y E++++
Sbjct: 2400 KESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED 2459
Query: 1570 EHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
+L + E K F EI A + +E E L+ L+
Sbjct: 2460 LKMKLVKIDLEKMKNAKEFE------KEISATKATVEYQKEVIRLLRENLR 2504
Score = 100 bits (248), Expect = 2e-20
Identities = 157/775 (20%), Positives = 329/775 (42%), Gaps = 112/775 (14%)
Query: 44 LPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTN 103
L + E ++ NMK+ +N+ T++ E K + L R++ E G ++ + +++
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL-RIEIEMLGLSKRLQESH 1434
Query: 104 IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
E+K V K +LQ +++L S ++ + +KE K ++ E+L
Sbjct: 1435 DEMK-SVAKEKDDLQRLQEVLQSESDQLK----------ENIKEIVAKHLETEEELKVAH 1483
Query: 164 ILLLEKDVTAAQAELEKAFAGTETE------KALRLRLESKLSEM-KKMHEGDLAMALVL 216
L E++ T + + + TE +A+ +L++K+ E+ +K + ++ +
Sbjct: 1484 CCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEV 1543
Query: 217 DEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
EK +++ K K+K++ +Q ++ + ++ R ++ +E
Sbjct: 1544 QEKVNELKQFKEHRKAKDSALQSIESKMLELT-----------------NRLQESQEEIQ 1586
Query: 277 AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE 336
++ ++E +E +Q + L+E +EI + K S +++ +T +++EK
Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM--- 1643
Query: 337 LNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAA---LRSQNLTKSTE 393
EIE L F + L+ +T+ + ++ L +++ LRS T E
Sbjct: 1644 --CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 394 NHRLRRSIKK-ITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE 452
+L+ ++++ IT++L + Q+E + + L+E H+E TI LR V + NE++
Sbjct: 1702 RDQLKENLRETITRDL-EKQEELKIVHMHLKE-HQE------TIDKLRGIVSEKTNEISN 1753
Query: 453 REKAMENRYKSLLSESNK----------KLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
+K +E+ +L ++ K L Q++ I L ++K L +KDLE
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM-QKDLE 1812
Query: 503 VIQQNCYLM-AAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQ 561
N L ++L+ LIT K + + + KKQ D + L+ E
Sbjct: 1813 --NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
Query: 562 -DIYTHLVKSLQESDSI------------------NNLQAELNKIFALRKQLEQDVLSYQ 602
++ L ++L+E S+ + L+ L + A +++Q++ + +
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930
Query: 603 NLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELK-------- 654
L K +E + ++R + E SD L +E + +++ ++EL+
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK-KIQELQKKELQLLRVKEDV 1989
Query: 655 ----KKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL-ASTEQTELLASKED 709
KK++++ QL K+ N ++ D FQ +L S E+ ++A + D
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMD----NFQ---LTKKLHESLEEIRIVAKERD 2042
Query: 710 E-----DTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
E +++K+ D I L + + K +G TES C
Sbjct: 2043 ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKC 2097
Score = 78.2 bits (191), Expect = 7e-14
Identities = 152/721 (21%), Positives = 293/721 (40%), Gaps = 106/721 (14%)
Query: 964 LQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGE 1023
L+S+ LEL+ ++KE T KQ+ + L ++ +E + K ++ + + +A+ +
Sbjct: 644 LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK---KKMQVDLEKELQSAFNEI--- 697
Query: 1024 QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLS 1083
K TS + D ++ D + E++ +I DL + KE E+ V
Sbjct: 698 ---TKLTSLI--DGKVPKDLLCNLELEGKI---TDLQKELN-KEVEENEALREEVILLSE 748
Query: 1084 SKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAI 1143
KS PS E E L+++I D EL I +K SE +
Sbjct: 749 LKSLPS------------------EVERLRKEIQDKSEELH-----IITSEKDKLFSE-V 784
Query: 1144 ITVLCGTEGAQDGLSKPKN----------GSDGEEMTFSSLHQVRYVKHVKILGP---LA 1190
+ +G + + K K+ +D E F +LH K+ +L +
Sbjct: 785 VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844
Query: 1191 PEMID-SRVLENLKQQL----EEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL 1245
E+++ S+ + L E YK Q+ Q ++ ++ ++ L DS
Sbjct: 845 QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE--NRDST 902
Query: 1246 VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305
+Q+ RE +L ++++ + + + T+ + ++L Q + + + ++
Sbjct: 903 LQTVEREKTLITEKLQQ-------TLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDT 955
Query: 1306 AEL-LEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364
+ ++ E+L +S+ T N L +I E+ H+ + E +
Sbjct: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK--------DE 1007
Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEH-------IQEIRTLRKRLEESIKTNE 1417
++ D+KQD E + T + + ++E IQE L++ LE I E
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477
+L+ L+ ++ + G EL EI +++N A IK + +
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQ--QEI-VAQEKNHA-----IKKEGELSRTC 1119
Query: 1478 DKL---RESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELS 1534
D+L E L K+ L+ Q++ +V+EE +QK+ +E E L E++ L
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE----NLKNELKNKELTLE 1175
Query: 1535 RVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKL------DEEHRR--LREASGEGWKGQD 1586
++ E Q L++N + ++S+ E K ++L + +H R +RE G + ++
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235
Query: 1587 PFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPE 1646
+ H L E Q +L RS+ + T Q + L + K QE L + +P
Sbjct: 1236 ELKIAHIHLKEHQETIDELRRSV-SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294
Query: 1647 V 1647
V
Sbjct: 1295 V 1295
Score = 68.9 bits (167), Expect = 4e-11
Identities = 157/756 (20%), Positives = 296/756 (39%), Gaps = 160/756 (21%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117
+ +KD +++L+ EN NL +++ E M+ +++ + LK+E + LK L
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMK-ERDNLRRVEETLKLERDQLKESL 1912
Query: 118 QE---REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAA 174
QE R+ + + K L++ + +++E +K Q+ D+ +KD+ +
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI--------QKDLDKS 1964
Query: 175 QAELEKAFAGTETEKALRLRLES-------KLSEM------------------------- 202
+ EL+K + ++ LR++ K++EM
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Query: 203 KKMHEGDLAMALVLDEKDRLIEELKLSLK-SKEALIQCLKE-----EKSQMACPDENVSS 256
KK+HE + +V E+D L +K SLK ++ I L+E ++ P++ + S
Sbjct: 2025 KKLHESLEEIRIVAKERDEL-RRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083
Query: 257 GELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK- 315
+ L + RE+ R E ++ E + E + L DL E+EI +K+ S++
Sbjct: 2084 DGQQHLTESLREKCSRIKEL--LKRYSEMDDHYECLNRLSLDL---EKEIEFQKELSMRV 2138
Query: 316 ---------RDKAIQGLTMA----------------------LKSKEKKVEELNS----- 339
+ K I+ L A K KE++ E +N
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 340 --EIEKLSAAFAKAREALQKAQTQEFQGSE---DYETALSGKEALSAALRSQNLTKSTEN 394
E+EK K + Q + + + L +E L S+ + TE
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEF 2258
Query: 395 HRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDL-RNEVEKLRNEVNER 453
++ + K++TQ L + R +EK L+ ++++ C + + N + + NE E
Sbjct: 2259 QQVLSNRKEMTQFLEEWLNTRFDIEK-LKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2317
Query: 454 E-------KAMENRYKSLLSESNKKLHNQEQVIK-------------------HLTESTN 487
E K E KSL E N+KL Q +K H+T
Sbjct: 2318 EERSATISKEWEQDLKSL-KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRAT 2376
Query: 488 QKDVLLQKFNE--------------KDLEVIQQNCYLMAAEDLELRSEGLITE--KCSSQ 531
Q + +K E K+ ++I+ L D+ + + + E KC +
Sbjct: 2377 Q--LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434
Query: 532 QPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVK-SLQESDSINNLQAELNKIFA- 589
+ + K + Y+E I+ LK + LVK L++ + + E++ A
Sbjct: 2435 TKETIQVLQDKVALGAKPYKEEIEDLKMK------LVKIDLEKMKNAKEFEKEISATKAT 2488
Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQV---E 646
+ Q E L +NLR++ + Q + + + T + +N + + E
Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSE 2548
Query: 647 HFSQEE----LKKKVSDLIQLVKELYTDNQHLKKTI 678
H E+ LK++ LI+ EL ++NQHL +
Sbjct: 2549 HIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584
Score = 53.9 bits (128), Expect = 1e-06
Identities = 105/469 (22%), Positives = 189/469 (40%), Gaps = 87/469 (18%)
Query: 270 KERETEAAQMEHQKERNSFEERIQALEED-----LREKE--REIATEKKNSLKR---DKA 319
K E ++ Q E S E R QA+E+D L EK+ +++ EK +L R +
Sbjct: 346 KRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSS 405
Query: 320 IQGLTMALKSKEKK-----------------------VEELNSEIEKLSAAFAKAREALQ 356
L LK+K K+ + ++ KLS + +
Sbjct: 406 SLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESV 465
Query: 357 KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE 416
+++ F + D + + A + L +N+ +E + LR + + L+ E+E
Sbjct: 466 CSESDVFSNTLDTLSEIEWNPA-TKLLNQENI--ESELNSLRADYDNLVLDYEQLRTEKE 522
Query: 417 RLEKDLE--------EAHREKSKGDCTIRDLRNEVEKLRNEVNERE---KAMENRYKS-- 463
+E L+ EA K+K D ++ L +E+ L+N V E + +EN S
Sbjct: 523 EMELKLKEKNDLDEFEALERKTKKDQEMQ-LIHEISNLKNLVKHAEVYNQDLENELSSKV 581
Query: 464 -LLSE------------SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD---LEVIQQN 507
LL E ++KL N + + + ES + Q + + L+ +++
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641
Query: 508 CYLMAAEDLELR---SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIY 564
+L +E+LEL+ E T K ++ +KK D E+ +Q E
Sbjct: 642 AFL-RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 565 THLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---------KTLEEQISEI 615
T L+ D + NL+ E KI L+K+L ++V + LR K+L ++ +
Sbjct: 701 TSLIDGKVPKDLLCNLELE-GKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERL 759
Query: 616 RR----REEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
R+ + EE + S++ S + + +R Q EE+ K DL
Sbjct: 760 RKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ---GLLEEIGKTKDDL 805
Score = 40.8 bits (94), Expect = 0.013
Identities = 88/419 (21%), Positives = 169/419 (40%), Gaps = 96/419 (22%)
Query: 347 AFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQ 406
+F + ALQ A T ++ + Y +S EAL R + + L++ +++++
Sbjct: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMD-------LKKQLEEVSL 364
Query: 407 ELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLS 466
E E+++L + LEE +DL ++K++NE E M SL
Sbjct: 365 ETRAQAMEKDQLAQLLEE------------KDL---LQKVQNEKIENLTRMLVTSSSLTL 409
Query: 467 ESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE 526
+ K + +V L + K+ N D I N IT
Sbjct: 410 QQELKAKRKRRVTWCLGKINKMKN-----SNYADQFNIPTN----------------ITT 448
Query: 527 KCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESD--------SIN 578
K K + E+ + + E D++++ + +L E + +
Sbjct: 449 K--------------THKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQE 494
Query: 579 NLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRR----EEESFSLYSDQTSYLS 634
N+++ELN +LR + VL Y+ LR EE +++ + E E+ + + +
Sbjct: 495 NIESELN---SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ 551
Query: 635 ICLEENN-RFQVEHFS--QEELKKKVSDLIQLVKEL---------YTDNQHLKKTIFDLS 682
+ E +N + V+H ++L+ ++S ++L++E Y D+Q L+ DLS
Sbjct: 552 LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611
Query: 683 CMGFQGNGFPDRLASTEQ-TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS 740
L S E ++ + D +T+ + E FL ++L + E MK+L+
Sbjct: 612 Y----------SLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKEKMKELA 659
Score = 38.9 bits (89), Expect = 0.048
Identities = 68/310 (21%), Positives = 128/310 (41%), Gaps = 58/310 (18%)
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
K+ IC ++ N +I E + + +++ +++ L L EK EKLF N +
Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS---LKEKNEKLFKNYQ 2347
Query: 1321 SV------GVEMNTQNE--------------LMERIEEDNLTYQHLLPESPEPSASHALS 1360
++ G ++N + E+I E ++ L E+ E SA H S
Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE----LENSLHEAKE-SAMHKES 2402
Query: 1361 DYETSEKSF------FSRDQKQDNET----EKTSVMVNSFSQDLLM---EHIQEIRTLRK 1407
+K ++ Q + +E+ EKT + + + + +EI L+
Sbjct: 2403 KIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKM 2462
Query: 1408 RLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLI 1467
+L + K K+ E++ + + + E+ L LR+ QA + +I
Sbjct: 2463 KLVKIDLEKMKNAKEFEKE----ISATKATVEYQKEVIRLLREN---LRRSQQAQDTSVI 2515
Query: 1468 KGSRDKQKENDKLR----ESLSRKTVSL----EH--LQREYASVKEENERLQKEGSEKER 1517
D Q N L + + T +L EH L++E + +K++NE+L K+ +E
Sbjct: 2516 SEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLS 2575
Query: 1518 HNQQLIQEVR 1527
+NQ L EV+
Sbjct: 2576 NNQHLSNEVK 2585
Score = 38.5 bits (88), Expect = 0.063
Identities = 94/457 (20%), Positives = 181/457 (39%), Gaps = 92/457 (20%)
Query: 58 RNMKDFENQITELKKENFNL--KLRIYFLEE------------RMQQEFHGPTEHI--YK 101
+ +K + +T++K+E K + F++E +QQ+ P+ + K
Sbjct: 2171 KKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK 2230
Query: 102 TNIELKVEVESLKRELQERE---------QLLIKASKAVESLAEAGGS--EIQRVKEDAR 150
N + + +E + ++ E E Q+L + + L E + +I+++K +
Sbjct: 2231 LNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQ 2290
Query: 151 K---KVQQVEDLLTKRILLL------------------EKDVTAAQAELEKAFAGTETEK 189
K ++ QV + RI+ + E+D+ + + + EK F +T K
Sbjct: 2291 KENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLK 2350
Query: 190 ---ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSL-KSKEALIQCLKEEKS 245
A ++ + K H A L ++ I EL+ SL ++KE+ + KE K
Sbjct: 2351 TSLASGAQVNPTTQDNKNPHVTSRATQLTTEK----IRELENSLHEAKESAMH--KESKI 2404
Query: 246 QMACPDENVSSGELRGLCAAPRE-----EKERET-EAAQMEHQKERNSFEERIQALEEDL 299
+ V++ + L A E EK +ET + Q + ++E I EDL
Sbjct: 2405 IKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEI----EDL 2460
Query: 300 REKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQ 359
+ K +I EK + K EK++ + +E RE L+++Q
Sbjct: 2461 KMKLVKIDLEKMKNAKEF-------------EKEISATKATVEYQKEVIRLLRENLRRSQ 2507
Query: 360 TQEFQG--SEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERER 417
+ SE + S K + ++T+ L+ ++ +E+S L+Q+ E+
Sbjct: 2508 QAQDTSVISEHTDPQPSNKPLTCGG--GSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2565
Query: 418 LEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNERE 454
L K E + L NEV+ + +RE
Sbjct: 2566 LIKQKNELLSNN-------QHLSNEVKTWKERTLKRE 2595
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 131 bits (330), Expect = 5e-30
Identities = 361/1762 (20%), Positives = 690/1762 (39%), Gaps = 295/1762 (16%)
Query: 48 SEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK 107
SEE ++ + + K+ + EL K+ L+ R +E+M+ K + E K
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELTKK---LQTREREFQEQMKVALEKSQSEYLKISQE-K 529
Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167
+ ESL E E ++ KA+ + +E ++Q+ E R ++ ++E L K +
Sbjct: 530 EQQESLALEELELQK------KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN 583
Query: 168 E---KDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLD------ 217
+ KD+ A E EK + K + + +E +E++ + H+ D L
Sbjct: 584 KNQSKDL-AVHLEAEK----NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQY 638
Query: 218 --EKDRLIE----ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAA------ 265
E ++L E E + LK KE + Q EE ++ +V EL L +
Sbjct: 639 QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 266 PREEKERETEAAQMEHQKERNSFEERIQALEEDLRE------KEREIATEKKNSLKRDKA 319
R + E E + + K + E ++ + ++ KE E++ ++ +D+
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ- 757
Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEAL 379
I L + LK ++K ++E + +E L A ++ LQ+A + + Y++A
Sbjct: 758 INQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK-LDVFQSYQSA------- 809
Query: 380 SAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT---- 435
+ TK+ E + ++ Q+L DL+ ER L K + E +K K CT
Sbjct: 810 -----THEQTKAYEEQ-----LAQLQQKLLDLETERILLTKQVAEVEAQK-KDVCTELDA 858
Query: 436 ----IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTN---- 487
++DL ++EK +E+ ++ K++ Y+S L + NK+ QEQ + L E N
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE---QEQTKQILVEKENMILQ 915
Query: 488 -------QKDVLLQKFNEKDLEV-IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539
+ ++L QK + K+ + I Y ++ E + E + +K Q K +
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME-KVKQKAKEMQETLKKKL 974
Query: 540 FSKEKKQSSDYEE-LIQVLKKEQDIYTHLVKSLQE-----SDSINNLQA----ELNKIFA 589
+E K + E +++ +KE+ +++ Q SD+++ L+ ++ +
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 590 LRKQLEQDVLSY--QNLRKTLEE--QISEIRRREEESFSLYSDQTSYLSICLEENNRFQV 645
+ ++ DV+S + L + EE +I EI+ +E+E Q L C +E ++
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
Query: 646 EHFS-------------QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
QE+LK+K + + L ++ HL+K DL+
Sbjct: 1095 TWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN------KSLK 1148
Query: 693 DRLASTEQTELLASKEDEDTIKIGE--------DDEINFLSDQHLQQSNEIMKDLSKGGC 744
+ EQ L +ED K+ E D+E L H ++SN+ ++D S
Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSH-EKSNKSLEDKSLEFK 1207
Query: 745 KNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLL 804
K + I C A + IN+ + N + + + KV LL+
Sbjct: 1208 KLSEELAIQLDIC-CKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 805 GQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQ-TNSFSKPHDELKLSCEAQLVKAGEV 863
++E E L T +Q + F Q T+ + +++K
Sbjct: 1267 KTCTVSELEAQLRQL------TEEQNTLNISFQQATHQLEEKENQIK------------- 1307
Query: 864 PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALL 923
A ++++ TE + L+ + ++A EK + EN++ V
Sbjct: 1308 ----SMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVT------- 1356
Query: 924 SLPGITNREAKKSRLPI------LIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKE 977
+ E K+ ++ I L + L N L + ++ L+ Q E + EL
Sbjct: 1357 ----LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL-- 1410
Query: 978 FKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDK 1037
L Q L+ V T K ++A V + + E K K S + +
Sbjct: 1411 -------LDQVQDLSFKV----DTLSKEKISALEQVD-DWSNKFSEWKK-KAQSRFTQHQ 1457
Query: 1038 EMDSDQQRSYEIDS-EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMG 1096
+ Q E+ S E D+ +L + + ++ KS+ K S +
Sbjct: 1458 NTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE 1517
Query: 1097 TD-QSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQD 1155
T+ +S++ +++ QK ++E+ E +N + QK + E + + +
Sbjct: 1518 TELKSQTARIMELEDHITQKTIEIESLNEVLKN--YNQQKDIEHKELVQKL---QHFQEL 1572
Query: 1156 GLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV------LENLKQQLEEQ 1209
G K + EE + +QV +K E ++ V L+ L+ +LE +
Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632
Query: 1210 ------EYKLQKEQN---LNMQLFSEIHNLQNKFRDLSPPRYDSL---VQSQARELSLQR 1257
E K + EQ + QL S++ + +++ + L +Q + RE+ +
Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 1258 QQIKDGHG----ICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLE 1313
+++K ++ R N + A+ E +A D CV + ++E+++ L + E
Sbjct: 1693 EKLKSVESSQSETLIVPRSAKN--VAAYTEQEEA-DSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 1314 KLFL-------NGKSVGVEMNTQ----------------------NELMERIEEDNLTYQ 1344
KL S EM Q L E +EE N Y
Sbjct: 1750 KLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 1345 HLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRT 1404
++ + E + + ++ F QK E E T ++ ++L +++
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
Query: 1405 LRKRLEESIKTNEKLRKQLERQG----SEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQ 1460
R +EE EKL+ + G +E ++ +T + + L S + Q+
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN---MEAQHN 1926
Query: 1461 ALNAMLIKGSRDKQKENDK-------LRESLSRKTVSLEHLQREYASVKEENERLQKEGS 1513
L L R+KQK + LR LE L++EY +EE + ++E
Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986
Query: 1514 EKERHNQQLIQEVRCSGQELSRVQEEVKLR-----QQLLSQNDKLLQSLRVE----LKAY 1564
E +HN L Q +R +L++ ++E+++ + +LL+S + E LK
Sbjct: 1987 EL-KHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
Query: 1565 EKLDEEHRRLREASGEGWKGQD-----PFRDLHSLLMEIQ-------------------A 1600
+ D++ +R + E ++ RDL + L E+Q
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTI 2105
Query: 1601 LRLQLERSIETSSTLQSRLKEQ 1622
+ LQ + + +T+ S+LKEQ
Sbjct: 2106 MELQTQLAQKTTLISDSKLKEQ 2127
Score = 105 bits (261), Expect = 5e-22
Identities = 301/1485 (20%), Positives = 591/1485 (39%), Gaps = 299/1485 (20%)
Query: 157 EDLLTKRILLLEKDVTAAQ---AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMA 213
++ L +R+ +E+ +++ + +EL A+ + EK + S+ + +L
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 214 LVLDE--KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKE 271
L +D+ K L EE SL+ K+ I L+ +Q++ + + +G + P + E
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQ---TQVSLLKQRLRNGPMNVDVLKPLPQLE 252
Query: 272 RETEAAQMEHQKERN--------SFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGL 323
+ E E E + + + ++ L++ ++ +E + K+ + L
Sbjct: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLL 312
Query: 324 TMALKSKEKKVEELNSEIEKLS----AAFAKAREALQKA-----QTQEFQGSEDYETALS 374
T ++ +++++E E+EK+ A K L+ A Q ++ +G ET
Sbjct: 313 TSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQ 372
Query: 375 GKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDC 434
E L K E +LR IK++T + +L++++E+ E+ A E K
Sbjct: 373 MHETLEM--------KEEEIAQLRSRIKQMTTQGEELREQKEKSER---AAFEELEKALS 421
Query: 435 TIRDLRNEVEKLRNEVNER----EKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490
T + KL+ E++E+ EK E SL E ++ +++V+ + +S+ ++
Sbjct: 422 TAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV---KQEVVDVMKKSSEEQI 478
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
LQK +EK+L R E +T+K +++ ++
Sbjct: 479 AKLQKLHEKEL----------------ARKEQELTKKLQTRE---------------REF 507
Query: 551 EELIQV-LKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLE 609
+E ++V L+K Q Y + + ++ +S+ + EL K A+ + E + Q +T
Sbjct: 508 QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK-KAILTESENKLRDLQQEAETYR 566
Query: 610 EQISEIRRREEESFSLYSDQTSYLSICLE-ENNRFQVE-HFSQEELKKKVSDLIQLVKEL 667
+I E+ E+S +Q+ L++ LE E N+ E E+ K ++ L L
Sbjct: 567 TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
+T+ + K + + E L K +++ + +D EI F
Sbjct: 627 WTEKLQVLKQQYQ------------------TEMEKLREKCEQEKETLLKDKEIIF--QA 666
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787
H+++ NE K L K K L S++S+ A LEE +++L +K
Sbjct: 667 HIEEMNE--KTLEKLDVKQTELESLSSELSEV--LKARHKLEEE--LSVLKDQ-TDKMKQ 719
Query: 788 LLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFV--QTNSFSKP 845
LE++ D K + + + + E EVS + +TEK K + + + + + K
Sbjct: 720 ELEAKMDEQKNHHQQQVDSI-IKEHEVSIQ----RTEKALKDQINQLELLLKERDKHLKE 774
Query: 846 HDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE---AWEEKPINTA 902
H + EA + ++ + +Q + + D+ + AT E A+EE+
Sbjct: 775 HQAHVENLEADIKRS---------EGELQQASAKLDVFQSYQSATHEQTKAYEEQ----L 821
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVT 962
+ + +L +L + EA+K ++V T
Sbjct: 822 AQLQQKLLDLE-----TERILLTKQVAEVEAQK----------------------KDVCT 854
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPG 1022
+L + +++Q +++ + N ++ QK+ V E + +D
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK-----------------LEDGNK 897
Query: 1023 EQKGIKTTSSVWRDKE-----MDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTS 1077
EQ + T + +KE M Q++ EI L S KE+ +L+
Sbjct: 898 EQ---EQTKQILVEKENMILQMREGQKKEIEI---------LTQKLSAKEDSIHILN-EE 944
Query: 1078 VATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETEL-EGYQNFIFQL-QK 1135
T ++ + KV + E+ LK+K+ D E +L + +N +L QK
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQET---------LKKKLLDQEAKLKKELENTALELSQK 995
Query: 1136 HSQCSEAIITVL-CGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMI 1194
Q + ++ + + G D +S+ + + + + +H+ E+
Sbjct: 996 EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR--------------RELN 1041
Query: 1195 DSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELS 1254
D V+ +++L +Q +LQ EIH +Q +Q + +E++
Sbjct: 1042 D--VISIWEKKLNQQAEELQ-----------EIHEIQ--------------LQEKEQEVA 1074
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL-- 1312
+Q+I + ++ MN I +E D QEQL Q + + L
Sbjct: 1075 ELKQKIL----LFGCEKEEMNKEITWLKEEGVKQDT---TLNELQEQLKQKSAHVNSLAQ 1127
Query: 1313 EKLFLNGKSVGVEMNTQNELMER-IEEDNLTYQHLLPESPEPSASHALSDYETSEKSF-- 1369
++ L +E++ L E ++ L +L E + S S +T+++ F
Sbjct: 1128 DETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 1370 -FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGS 1428
S +K + E S+ S++L ++ L+ K E L LE + +
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQ-----------LDICCKKTEAL---LEAKTN 1233
Query: 1429 EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGS---------RDKQKENDK 1479
E + S S+ ++ L+ H + + A+LIK R +E +
Sbjct: 1234 ELIN------ISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 1480 LRESLSRKTVSLEHLQREYASVK-------EENERLQKEG-------SEKERHNQQLIQE 1525
L S + T LE + + S+K E E LQKEG SEKE QL +E
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 1526 VRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+ + ++ ++EE+K ++ +S K L L V+L+ L E+
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392
Score = 99.8 bits (247), Expect = 2e-20
Identities = 316/1631 (19%), Positives = 670/1631 (41%), Gaps = 222/1631 (13%)
Query: 105 ELKVEVESLKRELQEREQLLIKAS-KAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
EL + L+RE ++ + +L ++ K++ +AE E ++ + A+K +Q+ D +
Sbjct: 159 ELVTAYQMLQREKKKLQGILSQSQDKSLRRIAEL--REELQMDQQAKKHLQEEFDASLEE 216
Query: 164 ----ILLLEKDVTAAQAELEKAFAGTETEKAL-RLRLESKLSEMKKMHEGDLAMALVLDE 218
I +L+ V+ + L + K L +L ++++ ++ E D
Sbjct: 217 KDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESD--------- 267
Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
+ E S+K+ E L Q +K +++ + E + S + + C EKE A
Sbjct: 268 -GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQ--CTLLTSEKE-----AL 319
Query: 279 MEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMA---------LKS 329
E ER E+I+ L + K + KN +++ + +G+ +A L+
Sbjct: 320 QEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM 379
Query: 330 KEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT 389
KE+++ +L S I++++ + RE +K++ F E+ E ALS + A R
Sbjct: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF---EELEKALSTAQKTEEARRK---L 433
Query: 390 KSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNE 449
K+ + +++ K +E LQQE R+++++ + ++ S+ ++ KL+ +
Sbjct: 434 KAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE---------EQIAKLQ-K 483
Query: 450 VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCY 509
++E+E A + + E KKL +E+ E Q V L+K + L++ Q+
Sbjct: 484 LHEKELARKEQ------ELTKKLQTRER------EFQEQMKVALEKSQSEYLKISQEKEQ 531
Query: 510 L--MAAEDLELRSEGLITEKCSSQQP--PGSKTIFSKEKKQSSDYEELIQVLKKE-QDIY 564
+A E+LEL+ + ++TE + + ++T ++ + S E+ +Q K + +D+
Sbjct: 532 QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591
Query: 565 THLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRRR-EE 620
HL + + + E +K + +QD L Q L++ + ++ ++R + E+
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQ 651
Query: 621 ESFSLYSDQTSYLSICLEENNRFQVEHFS--QEELKKKVSDLIQLVKELYTDNQHLKKTI 678
E +L D+ +EE N +E Q EL+ S+L +++K + + L
Sbjct: 652 EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLK 711
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLAS-KEDEDTIKIGED---DEINFLSDQHLQQSNE 734
M + D + Q ++ + KE E +I+ E D+IN L + L++ ++
Sbjct: 712 DQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL-ELLLKERDK 770
Query: 735 IMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPD 794
+K+ ++ + E+ I +G + F + + +E+ E
Sbjct: 771 HLKE------HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT-HEQTKAYEEQLAQ 823
Query: 795 LLKVVRELLLGQLFLTEQ--EVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLS 852
L + + +L ++ LT+Q EV + D TE H +Q + ++
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELD-------AHKIQVQDLMQQLEKQNSE 876
Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKP----INTALSAEHR 908
E ++ +V + L+D + + T+ L+ ++ + +K + LSA+
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE- 935
Query: 909 PENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQI 968
+++H + N+E K ++ K + L ++ +L++
Sbjct: 936 -DSIHILNEEYETKFK-----NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTA 989
Query: 969 LELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIK 1028
LEL + K+F + L +A+A G L Q + + ++ +
Sbjct: 990 LELSQKEKQFNA------KMLEMAQANSAGISDAVSRLETNQKEQIESLTEV--HRRELN 1041
Query: 1029 TTSSVWRDK--EMDSDQQRSYEI-----DSEICPPDDLASLPSCKENP----------ED 1071
S+W K + + Q +EI + E+ L C++ E
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIF 1131
V T++ Q SA V+ + D+++ LK + LE +L
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETK----------LKAHLEKLEVDLNK------ 1145
Query: 1132 QLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAP 1191
L++++ E ++ + E + +S+ + + F SL H K L
Sbjct: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS----SHEKSNKSLED 1201
Query: 1192 EMIDSRVL-ENLKQQLE----EQEYKLQKEQN--LNMQ------LFSEIHNLQNKFRDLS 1238
+ ++ + L E L QL+ + E L+ + N +N+ + S I + Q++ +
Sbjct: 1202 KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVK 1261
Query: 1239 PPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA--SDVDYCVAE 1296
+ EL Q +Q+ + IS Q ++ E +++ +D++ V E
Sbjct: 1262 EALL--IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE 1319
Query: 1297 --------GFQEQL----NQCA-----ELLEKLEKLFLNGKSVGVEMNTQNELMERIEED 1339
G Q+Q C EL E + + L + + + + L +++ +
Sbjct: 1320 KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
Query: 1340 NLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLL--ME 1397
N+ Q+ + S + +A +L EK DQ QD S V++ S++ + +E
Sbjct: 1380 NVQLQNSISLSEKEAAISSLRKQYDEEKCELL-DQVQD-----LSFKVDTLSKEKISALE 1433
Query: 1398 HIQEI--------RTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
+ + + + R + T ++L+ QLE + E + I + L
Sbjct: 1434 QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI--------NLLK 1485
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSL----EHLQREYASVKEEN 1505
E+ K+ L + +K+ L L +T + +H+ ++ ++ N
Sbjct: 1486 EELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLN 1545
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE-EVKLRQQLLSQNDKLLQSLRVELKAY 1564
E L+ +K+ +++L+Q+++ QEL ++ VK ++ + + + S++ EL+
Sbjct: 1546 EVLKNYNQQKDIEHKELVQKLQ-HFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET- 1603
Query: 1565 EKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRL-QLERSIETS-STLQSRLKEQ 1622
+K + EH L S E + + L L A +L +L+R E + ++ +L Q
Sbjct: 1604 KKKELEHVNLSVKSKE-----EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQ 1658
Query: 1623 LARGAEKAQEG 1633
+ E+ ++G
Sbjct: 1659 MEEKEEQYKKG 1669
Score = 68.2 bits (165), Expect = 7e-11
Identities = 253/1347 (18%), Positives = 522/1347 (38%), Gaps = 259/1347 (19%)
Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE--------- 452
KK+ Q++S+ QQ+ L++ L A + S T +R+ +++E
Sbjct: 3 KKLKQKISEEQQQ---LQQALAPA--QASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGD 57
Query: 453 ----------REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
R ++E+ ++S + ES + ++E +++ T+ ++ L N DL+
Sbjct: 58 TQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVR-----TSSRESL----NRLDLD 108
Query: 503 VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS---DYEELI---QV 556
D++ +E L+ S + + + E+ SS Y EL+ Q+
Sbjct: 109 --SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQM 166
Query: 557 LKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR 616
L++E+ ++ Q+ L +I LR++L+ D Q +K L+E+
Sbjct: 167 LQREKKKLQGILSQSQDKS--------LRRIAELREELQMD----QQAKKHLQEEFDASL 214
Query: 617 RREEESFSLYSDQTSYLSICLEENNRF------------QVEHFSQEELKKKVSDLI--- 661
+++ S+ Q S L L Q E F++EE + + +
Sbjct: 215 EEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVED 274
Query: 662 -QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
VK L T Q +K+ + L ++T + S +++ T+ E +
Sbjct: 275 GTSVKTLETLQQRVKRQ--------------ENLLKRCKET--IQSHKEQCTLLTSEKEA 318
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
+ D+ LQ+ +I KDL ++ I+ A NL+ L
Sbjct: 319 LQEQLDERLQELEKI-KDL--------HMAEKTKLITQLRDAK-----------NLIEQL 358
Query: 781 FNEKATLLLESRPDLLKVV--RELLLGQLF--LTEQEVSGEHLDGKTEKTP--------- 827
+K ++ E++ + + + +E + QL + + GE L + EK+
Sbjct: 359 EQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEK 418
Query: 828 -------------KQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQ 874
K K E+ ++T K +E ++S + +L + + +K +S +
Sbjct: 419 ALSTAQKTEEARRKLKAEMDEQIKT--IEKTSEEERISLQQELSRVKQEVVDVMKKSSEE 476
Query: 875 TVAT-----EGDLLRFKHEAT-----REAWEEKPINTALSAEHRPENLHGVPGWQAALLS 924
+A E +L R + E T RE ++ + AL Q L+
Sbjct: 477 QIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA 536
Query: 925 LPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQ 984
L E + + IL + L ++ Q+ +++ILEL+ L++ NK
Sbjct: 537 L-----EELELQKKAILTESENKLRDL------QQEAETYRTRILELESSLEKSLQENKN 585
Query: 985 LHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIK-TTSSVWRDKEMDSDQ 1043
+ L + + + + T++ + E + +K ++W +K Q
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVM---------VEKHKTELESLKHQQDALWTEKLQVLKQ 636
Query: 1044 QRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESI 1103
Q E++ C++ E +L + + + + Q+E
Sbjct: 637 QYQTEMEK---------LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687
Query: 1104 NTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNG 1163
+ S+E + + H LE EL ++ Q K Q EA + + KN
Sbjct: 688 SLSSELSEVLKARHKLEEELSVLKD---QTDKMKQELEA-------------KMDEQKNH 731
Query: 1164 SDGEEMTFSSLHQVRYVKHVKILG------PLAPEMIDSRV------LENLKQQLEEQEY 1211
+ + H+V + K L L + D + +ENL+ ++ E
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 1212 KLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISR 1271
+LQ + + + +F + Q+ + + + L Q Q + L L+ ++I + +
Sbjct: 792 ELQ-QASAKLDVF---QSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEA 847
Query: 1272 QHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
Q + + +Q D+ Q+ Q +E+ +K++ L +S + N + E
Sbjct: 848 QKKDVCTELDAHKIQVQDL-------MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 1332 LMERI--EEDNLTYQ---------HLLPE--SPEPSASHALSDYETSEKSFFSRDQKQDN 1378
++I E++N+ Q +L + S + + H L+ E E F ++++K +
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILN--EEYETKFKNQEKKMEK 958
Query: 1379 ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQ-GSTSI 1437
+K M + + LL + + L+K LE + + KQ + E Q S I
Sbjct: 959 VKQKAKEMQETLKKKLLDQEAK----LKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 1438 FASGSELHSSLTSEIHFLRK-QNQALNAMLIKGSRDKQKENDKLRE----SLSRKTVSLE 1492
+ S L ++ +I L + + LN ++ + ++ ++L+E L K +
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVA 1074
Query: 1493 HLQRE---YASVKEENER----LQKEGSEKERHNQQLIQEVRCSGQEL-SRVQEEVKLRQ 1544
L+++ + KEE + L++EG +++ +L ++++ + S Q+E KL+
Sbjct: 1075 ELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKA 1134
Query: 1545 QLLSQNDKLLQSLRVELKAYEKL-------DEEHRRLREASGEGWKGQDPFRDLHSLLME 1597
L L +SL+ E+L +E+ R++ E + + + F+ L S
Sbjct: 1135 HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS---- 1190
Query: 1598 IQALRLQLERSIETSSTLQSRLKEQLA 1624
+ +S+E S +L E+LA
Sbjct: 1191 ---SHEKSNKSLEDKSLEFKKLSEELA 1214
Score = 58.9 bits (141), Expect = 4e-08
Identities = 104/511 (20%), Positives = 212/511 (41%), Gaps = 91/511 (17%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV---EVESLKRELQ-- 118
E +I +KK+ + +EE+ +Q G H+ + N +L+ EV L+ +L+
Sbjct: 1645 EQKIAAIKKQLLSQ------MEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSV 1698
Query: 119 ---EREQLLI-KASKAVESLAEAGGSEIQR-VKEDARKKVQQVEDLLTKRILLL-----E 168
+ E L++ +++K V + E ++ Q V++ +K+ ++ LT++ LL E
Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE 1758
Query: 169 KDVTAAQ------------AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMAL-- 214
K+ T + +LE A A ++++ L+ +L E K + +A +
Sbjct: 1759 KEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK 1818
Query: 215 ---------------VLDEKDRLIEELKLSLKSKEALIQ----CLKEEKSQMACPDENVS 255
V D+ + ++E +L+ + E I+ CL +K E ++
Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878
Query: 256 SG--ELRGLCAA-----PREEKERETEAAQMEH----------QKERNSFEERIQALEED 298
S +L+ L P E E TE H + + N E ++ E +
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
Query: 299 LREKEREIATEKKNSLKRDKAIQGLTMALKSK--EKKVEELNSEIEKLSAAF-AKAREAL 355
++ +EI +K+ K Q LK + +++ E++ E E L + ++ +
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLM 1998
Query: 356 QKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415
++ TQ Q ++ E + KE ++ A + + + +KKI ++ DL++
Sbjct: 1999 REFNTQLAQKEQELEMTI--KETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTA 2056
Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ 475
+R E+ L+ E + +RDL+ ++E+L+ + ++ + EN N
Sbjct: 2057 KRYEEILDAREEEMT---AKVRDLQTQLEELQKKYQQKLEQEENP------------GND 2101
Query: 476 EQVIKHLTESTNQKDVLLQKFNEKDLEVIQQ 506
I L QK L+ K+ E +Q
Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQ 2132
>gi|50658075 phosphodiesterase 4D interacting protein isoform 3
[Homo sapiens]
Length = 310
Score = 127 bits (320), Expect = 8e-29
Identities = 70/148 (47%), Positives = 97/148 (65%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++DFE + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ+
Sbjct: 142 LRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQD 201
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E
Sbjct: 202 KKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAA 261
Query: 180 KAFAGTETEKALRLRLESKLSEMKKMHE 207
+ A E EK L L KL + K E
Sbjct: 262 RMAALVEAEKECNLELSEKLKGVTKNWE 289
Score = 32.0 bits (71), Expect = 5.9
Identities = 40/161 (24%), Positives = 70/161 (43%), Gaps = 22/161 (13%)
Query: 172 TAAQAELEKAFAGTETEK-ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSL 230
T A + EK + E +L+LR+ M++ +E D R IE LK+ +
Sbjct: 139 TQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRE-----DIYKRNIE-LKVEV 192
Query: 231 KSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEE 290
+S + +Q K+ + EN++S E R+ E Q E + E
Sbjct: 193 ESLKRELQDKKQHLDKTWADVENLNSQN--------EAELRRQFEERQQETEHVYELLEN 244
Query: 291 RIQALEEDLREKEREIA-------TEKKNSLKRDKAIQGLT 324
+IQ L+E+ R + E A EK+ +L+ + ++G+T
Sbjct: 245 KIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 285
>gi|50658077 phosphodiesterase 4D interacting protein isoform 4
[Homo sapiens]
Length = 173
Score = 120 bits (300), Expect = 2e-26
Identities = 67/147 (45%), Positives = 93/147 (63%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ + +LKKENF+LKLRIYFLEERMQQ++ E IYK NIELKVEVESLKRELQ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
+Q L K VE+L +E++R E+ +++ + V +LL +I LL+++ A+ E +
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAAR 125
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHE 207
A E EK L L KL + K E
Sbjct: 126 MAALVEAEKECNLELSEKLKGVTKNWE 152
Score = 32.7 bits (73), Expect = 3.4
Identities = 30/109 (27%), Positives = 60/109 (55%), Gaps = 15/109 (13%)
Query: 402 KKITQELSDLQQERERLEKD---LEEAHREK---SKGDCTIR--DLRNEVEKLRNEVNER 453
+ ++Q L+DL++E L+ LEE ++K S+ D R +L+ EVE L+ E+ ++
Sbjct: 6 RTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDK 65
Query: 454 EKAMENRY---KSLLSESNKKLHNQ----EQVIKHLTESTNQKDVLLQK 495
++ ++ + ++L S++ +L Q +Q +H+ E K LLQ+
Sbjct: 66 KQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQE 114
Score = 31.6 bits (70), Expect = 7.7
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 15/107 (14%)
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
ELK+ ++S + +Q K+ + EN++S E R+ E Q E +
Sbjct: 50 ELKVEVESLKRELQDKKQHLDKTWADVENLNSQN--------EAELRRQFEERQQETEHV 101
Query: 285 RNSFEERIQALEEDLREKEREIA-------TEKKNSLKRDKAIQGLT 324
E +IQ L+E+ R + E A EK+ +L+ + ++G+T
Sbjct: 102 YELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVT 148
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 120 bits (300), Expect = 2e-26
Identities = 351/1644 (21%), Positives = 660/1644 (40%), Gaps = 263/1644 (15%)
Query: 101 KTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL 160
K + L+ V+SL+ L+ ++Q+ K E L + G EI+ A + Q
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG-EIEENLMKAEQMHQSFVAET 881
Query: 161 TKRILLLEKDVTAAQAELEKAFAGTET-EKALRL---RLESKLSEMKKMHEGDLAMALVL 216
++RI L++D +A Q + + + E EK L+L ++E++ +E++++ + + + L
Sbjct: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
Query: 217 DEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEA 276
E L E L L K ++I K E ++ EN G L+ + A+ +EK
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELT--QEN---GTLKEINASLNQEK------ 990
Query: 277 AQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE 336
M ++ SF I E+ + E + EK L+R + L K K +E
Sbjct: 991 --MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE 1048
Query: 337 LNS------------------EIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEA 378
NS E+E+L AFAK Q+ T+ E + + E
Sbjct: 1049 KNSKLECLLNECTSLCENRKNELEQLKEAFAKEH---QEFLTKLAFAEERNQNLMLELET 1105
Query: 379 LSAALRS-----QNLTKST------ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHR 427
+ ALRS QN +KS E L+ K+ +E++DL QE E+L K ++ H
Sbjct: 1106 VQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
Query: 428 EKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL-LSESNKKLHNQEQVIKHLTEST 486
++ IR+ E E RN+ N + + M+ K + L N +L E ++++
Sbjct: 1166 CQNLESEPIRNSVKERESERNQCNFKPQ-MDLEVKEISLDSYNAQLVQLEAMLRN----- 1219
Query: 487 NQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSK--TIFSKEK 544
K++ LQ+ +EK+ E +Q + DLE + + SQ+ G K I ++EK
Sbjct: 1220 --KELKLQE-SEKEKECLQHELQTIRG-DLETSN----LQDMQSQEISGLKDCEIDAEEK 1271
Query: 545 KQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQN- 603
S +E L Q+ HL SLQ ++N L EL KI + + + ++++ N
Sbjct: 1272 YISGPHE-----LSTSQNDNAHLQCSLQ--TTMNKLN-ELEKICEILQAEKYELVTELND 1323
Query: 604 --------LRKTLEE---QISEIRRREEESFSLY----------------SDQTSYLSIC 636
RK EE ++E++ ++S L+ ++Q
Sbjct: 1324 SRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAP 1383
Query: 637 LEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLA 696
L+E+N ++ S +E++ ++L +E + Q K + D C
Sbjct: 1384 LDESNSYEHLTLSDKEVQMHFAEL----QEKFLSLQSEHKILHDQHCQ-----------M 1428
Query: 697 STEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKI 756
S++ +EL + D++K E LS +++K++ G + G + S
Sbjct: 1429 SSKMSEL---QTYVDSLKA----ENLVLSTNLRNFQGDLVKEMQL-GLEEGLVPSLSS-- 1478
Query: 757 SDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSG 816
S + + L + +F L + + L S + + + ++F + +
Sbjct: 1479 SCVPDSSSLSSLGDSSFYR---ALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS--SLQE 1533
Query: 817 EHLDGKTEKTPKQKG--ELVHFVQTNSFSKPHDELKLSCEAQ-LVKAGEVPKVGLKDASV 873
E+L K + KG EL + + + ++L+ E+Q ++K E+ ++ + +
Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEV--YRQSLEKLEEKMESQGIMKNKEIQEL---EQLL 1588
Query: 874 QTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREA 933
+ E D LR ++ + E W++K + L E + Q LSL E
Sbjct: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESK----LAAEKKQTEQLSL----ELEV 1640
Query: 934 KKSRLPILIKPSRSLGNMYRLPATQ------EVVTQLQSQILELQGELKEFKTCNKQLHQ 987
+ +L L SRSL + A Q ++ + S+ E + + C+K Q
Sbjct: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQ 1700
Query: 988 KLIL-AEAVME-GRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQR 1045
L L E + E G P Q P + PGE K ++ + +
Sbjct: 1701 DLNLDIEKITETGAVKPTGECSGEQSP--DTNYEPPGEDKTQGSSECI---------SEL 1749
Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINT 1105
S+ + + P D L N ED+ ++ + S + ++ + D+ + +
Sbjct: 1750 SFSGPNALVPMDFLG-------NQEDI---HNLQLRVKETSNENLRLLHVIEDRDRKVES 1799
Query: 1106 -SNETEYLKQKIHDLETELEGYQNFIFQLQK--------HSQCSEAIITVLCG------- 1149
NE + L K+H E +L +L+K +S SE + C
Sbjct: 1800 LLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQR 1859
Query: 1150 ---TEGAQDGLSKPKNGSDGEEM-----TFSSLHQVRYVKHVKILGPLAPEM-------- 1193
+EG L + S E++ + + R++ L + E
Sbjct: 1860 VETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEAL 1919
Query: 1194 ---IDSRVLENLKQQLEEQEYKLQK-----EQNLNMQLFSEIHNLQNKFRDLSPPRYDSL 1245
D V++ K LE+ QK E+ L++ + SE + L+ + +S + +
Sbjct: 1920 YLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSV-VTSERNQLRGELDTMS--KKTTA 1976
Query: 1246 VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305
+ + ++ + Q+++ C+ Q +K ELLQ D E L
Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSD------VSELLKDK 2030
Query: 1306 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS 1365
L EKL+ L + +++ + T+ EL +I + N + L+ ES A + SDYE
Sbjct: 2031 THLQEKLQSLEKDSQALSL---TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087
Query: 1366 EKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRLEESIKTNEKLRKQL 1423
S E V F+ L E + ++R ++L I+ +EK + +
Sbjct: 2088 NVS---------KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHI 2138
Query: 1424 ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRES 1483
+ E + + S+ L L + ++NQ L +I + + + E + L+
Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQ-----MSEENQEL---VILDAENSKAEVETLKTQ 2190
Query: 1484 LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLR 1543
+ SL+ + + +++ E E L K+ EK+ +L ++ S + L +E+ ++
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-DKLLSSFKSLLEEKEQAEI- 2248
Query: 1544 QQLLSQNDKLLQSLRVELKAYEKL------DEEHRRLREASGEGWKGQDPFRDLHSLLME 1597
Q+ ++ ++ L+ +LK + D+E + E S + P + H L
Sbjct: 2249 -QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD-----PPIEEEHQLRNS 2302
Query: 1598 IQALRLQLERSIETSSTLQSRLKE 1621
I+ LR +LE + + +LKE
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKE 2326
Score = 88.2 bits (217), Expect = 7e-17
Identities = 162/743 (21%), Positives = 311/743 (41%), Gaps = 84/743 (11%)
Query: 57 ARNMKDFENQITELKKENFNLKLRIYFLEERMQ-----QEFHGPTEHIYKTNIE------ 105
A +K+ E + LK + NL+ + EE + E KT IE
Sbjct: 2139 AEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSL 2198
Query: 106 ---------LKVEVESLKRELQEREQLLIKASKAVES----LAEAGGSEIQRVKEDARKK 152
L+ E E+L +++QE++ L + K + S L E +EIQ +KE+++
Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ-IKEESKTA 2257
Query: 153 VQQVEDLL---TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGD 209
V+ +++ L + + L D +A + E E LR +E + ++ +
Sbjct: 2258 VEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 210 LAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGE----------- 258
L + L E + + LK +++ E ++ + + A EN S GE
Sbjct: 2318 LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAEN-SKGEVETLKAKIEGM 2376
Query: 259 ---LRGL---CAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKN 312
LRGL R EKE T Q E Q+ + E + E L+EKE+E K+
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKE-QERISELEIINSSFENILQEKEQEKVQMKEK 2435
Query: 313 SLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETA 372
S A++ L LK ++V L+++ E A ++ + ++ Q + + A
Sbjct: 2436 S---STAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 373 LSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK--DLEEAHREKS 430
+ L +++ +L + ++I++ + +Q + + + K +E H+
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 431 KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490
+ + +R+L E+E+ + + ++++ + +L S K L N+ ++ K S +K
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLE-VLQSSYKNLENELELTKMDKMSFVEK- 2610
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
+ K K+ E +Q+ + MA + EL+ E L EK + G + +E K S D
Sbjct: 2611 --VNKMTAKETE-LQREMHEMAQKTAELQEE-LSGEK---NRLAGELQLLLEEIKSSKDQ 2663
Query: 551 EELIQVLKKEQDIYTHLVKSLQ--ESDSINNLQAELNKIFALRKQLEQDVLSYQNL---- 604
+ + + E L KSL D + +I + +L + +Q L
Sbjct: 2664 LKELTLENSE------LKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 605 RKTLEEQISEIRRR---EEESFSLYSDQTSYLSICLEE-NNRFQVEHFSQEELKKKVSDL 660
K E +I R + +EE S + L EE NN + EELKK D
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
Query: 661 IQLVKELYTDNQHL--KKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGED 718
++ V +L +N+ K + SC + + E ++L A++E + T + D
Sbjct: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEE---KEILQKELSQLQAAQEKQKTGTV-MD 2833
Query: 719 DEINFLSDQHLQQSNEIMKDLSK 741
+++ L+ + +++ E +++ +K
Sbjct: 2834 TKVDELTTE-IKELKETLEEKTK 2855
Score = 85.1 bits (209), Expect = 6e-16
Identities = 294/1521 (19%), Positives = 587/1521 (38%), Gaps = 221/1521 (14%)
Query: 181 AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL 240
++A E ++ L R K+ E+ EG L D+ + ++ + L S EA +Q
Sbjct: 2 SWALEEWKEGLPTRALQKIQEL----EGQL------DKLKKEKQQRQFQLDSLEAALQKQ 51
Query: 241 KEEKSQMACPDENVS--SGELRGLCAAPREEKERETEAAQMEHQK------ERNSFEERI 292
K++ N+ + L +C + + K++ + Q++ + + NS +++I
Sbjct: 52 KQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQI 111
Query: 293 QALEEDLREKEREIATEKKNSLKRDKAIQG-----------LTMALKSKEKKVEEL---- 337
+ LE++L+ + E+ ++ + D ++ LT + K E+L
Sbjct: 112 EKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKY 171
Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ------NLTKS 391
N E+E+ A+ + K +Q + ++ +A S+ Q +L+ +
Sbjct: 172 NKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSN 231
Query: 392 TENHRLRRSIKKI----TQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
++ +RR QE++ + + ++D + + S + L+ + ++LR
Sbjct: 232 SQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291
Query: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
N++NE E ++ K + + NK Q Q+ K E ++ VL + +E Q +
Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIY--- 564
LE + + L TE S Q+ S E+K +E + L ++Q +
Sbjct: 352 QASTKYTALEQKLKKL-TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTL 410
Query: 565 --------THLVKSLQESDSINN-LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI--- 612
L + LQ++ +++N LQAEL+K+ ++++QLE ++ ++ E+
Sbjct: 411 DQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQAS 470
Query: 613 ----SEIRRREEES------FSLYSDQTSY-----------LSICLEENNRFQVE----H 647
+E+RR EE +S+Q + + CL ++ F E +
Sbjct: 471 QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKN 530
Query: 648 FSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCM-GFQGNGFPDRLASTEQTELLAS 706
SQE + + + + I + T + LK + DL + R EQ S
Sbjct: 531 TSQETMLRDLQEKINQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLS 589
Query: 707 KEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPG 766
K ++++ + E+ + L++ + K +E + H
Sbjct: 590 KTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET 649
Query: 767 CLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKT 826
CL+ + + +NE+ L R +L +R L LD K+ +
Sbjct: 650 CLKTQ---QIKSHEYNERVRTLEMDRENLSVEIRNL-------------HNVLDSKSVEV 693
Query: 827 PKQKGELVHFVQTNSFS--KPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDL-- 882
QK + Q FS K E++ C G+V + K + + D
Sbjct: 694 ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCY 753
Query: 883 --LRFKHEATREAWEEKPINTALSAEHR---------PENLHG---VPGWQAALLSLPGI 928
L ++E+ R+ + K + + +H+ P H + G Q ++ S
Sbjct: 754 QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSE 813
Query: 929 TNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQ---ILELQGELKEFKTCNKQL 985
EA +S I +R + L + +++ + LQ Q +++++GE++E +Q+
Sbjct: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 986 HQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQR 1045
HQ + + +D+ Q + T S +KE + Q
Sbjct: 874 HQSFV----------------AETSQRISKLQEDTSAHQNVVAETLSALENKEKEL-QLL 916
Query: 1046 SYEIDSEICPPDDLASLPSCKENPEDVLSPTS-VATYLSSKSQPSAKVSVMGTDQSESIN 1104
+ ++++E ++ L ED L ++ LS + + + + + + E +
Sbjct: 917 NDKVETE---QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELT 973
Query: 1105 TSNET-----EYLKQKIHDLETELEGYQNFIFQLQKH-SQCSE------AIITVLCGTEG 1152
N T L Q+ +L + E + N+I + +K S+ S+ I+ C G
Sbjct: 974 QENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1033
Query: 1153 -AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSR--VLENLKQQL--E 1207
A + LS+ + + L + ++R LE LK+ E
Sbjct: 1034 NAYEDLSQKYKAAQEKNSKLECLLNE------------CTSLCENRKNELEQLKEAFAKE 1081
Query: 1208 EQEY--KLQKEQNLNMQLFSEIHNLQNKFR-------DLSPPRYDSLVQSQARELSLQRQ 1258
QE+ KL + N L E+ +Q R + S L Q Q +
Sbjct: 1082 HQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
Query: 1259 QIKDGHGICVISRQHMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQC---AELLEKLEK 1314
K+ + + + Q M M E + L++ + V E E+ NQC ++ ++++
Sbjct: 1142 MQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESER-NQCNFKPQMDLEVKE 1200
Query: 1315 LFL---NGKSVGVEMNTQNE--LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF 1369
+ L N + V +E +N+ ++ E++ QH L + L D ++ E S
Sbjct: 1201 ISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG 1260
Query: 1370 FSRDQKQDNETE--------KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
+D + D E + TS N+ Q L + ++ L K E +L
Sbjct: 1261 L-KDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
Query: 1422 QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIK---GSRDKQKEND 1478
+L SE + + + +E L +E+ L + L+ L++ G ++ N+
Sbjct: 1320 ELNDSRSECITATRKM----AEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNE 1375
Query: 1479 KLRESLS---------RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
+ SL+ T+S + +Q +A ++E+ LQ E K H+Q + S
Sbjct: 1376 QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE--HKILHDQHCQMSSKMS 1433
Query: 1530 GQELSRVQEEVKLRQQLLSQN 1550
EL + +K +LS N
Sbjct: 1434 --ELQTYVDSLKAENLVLSTN 1452
Score = 84.3 bits (207), Expect = 1e-15
Identities = 239/1205 (19%), Positives = 472/1205 (39%), Gaps = 191/1205 (15%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ- 118
++D + ++ L E L +++ E ++ + E + K ELK E L +L+
Sbjct: 1790 IEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIE-LEKIVGELKKENSDLSEKLEY 1848
Query: 119 ---EREQLL--IKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTA 173
+ ++LL ++ S+ + S E + R ED V +V D +R L +E +++
Sbjct: 1849 FSCDHQELLQRVETSEGLNSDLEMHADKSSR--EDIGDNVAKVNDSWKERFLDVENELSR 1906
Query: 174 AQAE----------LEKAFAGTETEK-ALRLRLESKLSEMKKMHEGDLAMALVLDEKDRL 222
++E LE +TEK L E+K + + E +++V E+++L
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE---ELSVVTSERNQL 1963
Query: 223 IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM--- 279
EL K AL Q L E+ + E+ S L + A E KE+ TE Q
Sbjct: 1964 RGELDTMSKKTTALDQ-LSEKMKEKTQELESHQSECLHCIQVAEAEVKEK-TELLQTLSS 2021
Query: 280 ---EHQKERNSFEERIQALEEDLR----------------EKEREIATEKKNSLKR---- 316
E K++ +E++Q+LE+D + KE+E+ ++ SL+
Sbjct: 2022 DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 317 --------DKAIQG-------LTMALKSKEKKVEELNSEIEKL----SAAFAKAREALQK 357
KA++ + L S +++V +L IEKL A K +K
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 358 AQTQEFQGSEDYETALSGKEALSAALRSQNL-------------TKSTENHRLRRSIKKI 404
+ +E + + + + L + +Q L T T+ + RS+K
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGD---CTIRDLRNEVEKLRNEVNEREKA----M 457
+L L+ E+E L K ++E + S+ D + + L E E+ ++ E K +
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261
Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLE 517
+N+ K L+E+ L ++++K +S D +++ ++ + + L A E +
Sbjct: 2262 QNQLKE-LNEAVAALCGDQEIMKATEQSL---DPPIEEEHQLRNSIEKLRARLEADEKKQ 2317
Query: 518 LRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQES-DS 576
L C QQ S+ K + + E +++ + Q+ H + S
Sbjct: 2318 L---------CVLQQLKESEHHADLLKGRVENLERELEIARTNQE---HAALEAENSKGE 2365
Query: 577 INNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC 636
+ L+A++ + + LE DV++ +R E +E+++ +E L +S+ +I
Sbjct: 2366 VETLKAKIEGMTQSLRGLELDVVT---IRSEKENLTNELQKEQERISELEIINSSFENIL 2422
Query: 637 LE-ENNRFQVEHFS---QEELKKKVSDLIQLVKELYTDNQHLKKTIFDLS----CMGFQG 688
E E + Q++ S E L+ ++ +L + V L+ D + K +LS C+ +
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 689 NGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGY 748
L + ++ I+ ED + Q L++ +E + L KN
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK------QKLEKKDEEISRL-----KNQI 2531
Query: 749 LRHTE--SKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806
+ SK+S +G H + NL L E+ +L+S+ L+ E+L
Sbjct: 2532 QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVEL--EQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 807 LFLTEQEVSGEHLDGKT--EKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVP 864
E E+ +D + EK K + +T + H+ + + E Q +GE
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAK-----ETELQREMHEMAQKTAELQEELSGEKN 2644
Query: 865 KV-GLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPE-NLHGVPGWQAAL 922
++ G ++ + + D L+ E T E E + +L H+ + G + A
Sbjct: 2645 RLAGELQLLLEEIKSSKDQLK---ELTLENSE---LKKSLDCMHKDQVEKEGKVREEIAE 2698
Query: 923 LSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCN 982
L EA+K +L+ ++ + +E +T + + + E+ K+
Sbjct: 2699 YQL---RLHEAEKKHQALLLDTNKQY--EVEIQTYREKLTSKEECLSSQKLEIDLLKSSK 2753
Query: 983 KQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSD 1042
++L+ L ++E + + +K + + ++ E
Sbjct: 2754 EELNNSLKATTQILE--------------------ELKKTKMDNLKYVNQLKKENERAQG 2793
Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSES 1102
+ + + SCK+ E+ + L + + +VM T E
Sbjct: 2794 KMK--------------LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839
Query: 1103 INTSNE-TEYLKQKIHDLETELEGYQNFIF---QLQKHSQCSEAIITVLCGTEGAQDGLS 1158
E E L++K + + L+ Y + + +L+K + E + LC + QD
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRG 2899
Query: 1159 KPKNG 1163
P G
Sbjct: 2900 SPLLG 2904
Score = 80.9 bits (198), Expect = 1e-14
Identities = 319/1506 (21%), Positives = 585/1506 (38%), Gaps = 242/1506 (16%)
Query: 234 EALIQCLKEE----KSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
E L+EE K + P + V EL LC R+ E+ E +ME Q + E
Sbjct: 1525 EVFCSSLQEENLTRKETPSAPAKGVE--ELESLCEVYRQSLEKLEE--KMESQGIMKNKE 1580
Query: 290 ERIQALEEDLREKEREIATEKKNSLKRDKAIQG-LTMALKSKEKKVEELNSEIEKLSAAF 348
IQ LE+ L + +E+ +K L ++ Q LT E K+ + E+LS
Sbjct: 1581 --IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLEL 1638
Query: 349 AKAREALQ--KAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQ 406
AR LQ ++ G D E A+ G+ S + ++ +++TE R+ K
Sbjct: 1639 EVARLQLQGLDLSSRSLLGI-DTEDAIQGRNE-SCDISKEHTSETTE-----RTPKHDVH 1691
Query: 407 ELSDLQQERERLEKDLE---EAHREKSKGDCTIRDL---------RNEVEKLRNEVNERE 454
++ D +++ L D+E E K G+C+ ++ + ++E
Sbjct: 1692 QICDKDAQQD-LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELS 1750
Query: 455 KAMENRYKSLLSESNKK-LHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAA 513
+ N + N++ +HN + +K E++N+ LL ++D +V +
Sbjct: 1751 FSGPNALVPMDFLGNQEDIHNLQLRVK---ETSNENLRLLHVIEDRDRKVESLLNEMKEL 1807
Query: 514 ED-LELRSEGLIT--EKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKS 570
+ L L+ L+T E C + I + KK++SD E ++ + + L++
Sbjct: 1808 DSKLHLQEVQLMTKIEACIELEK-----IVGELKKENSDLSEKLEYFSCD---HQELLQR 1859
Query: 571 LQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT----LEEQISEIRRR----EEES 622
++ S+ +N+ E++ + R+ + +V + K +E ++S IR E E+
Sbjct: 1860 VETSEGLNS-DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
Query: 623 FSLYSD----QTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
L +D QT L + + N+ +V +EEL S+ QL EL D K T
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL--DTMSKKTTA 1976
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDE--DTIKIGEDD--EINFLSDQHLQQSNE 734
D + E+T+ L S + E I++ E + E L +E
Sbjct: 1977 LDQLSEKMK-----------EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE 2025
Query: 735 IMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPD 794
++KD + H + K+ + L + N +A L EK L+ ES
Sbjct: 2026 LLKDKT----------HLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES--- 2072
Query: 795 LLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCE 854
E L Q L+E + ++ E +KGE ++ +S + +L+ E
Sbjct: 2073 ------ESL--QARLSESDYEKLNVSKALEAALVEKGEFA--LRLSSTQEEVHQLRRGIE 2122
Query: 855 AQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHG 914
V+ K L A + E ++ ++K N + EN
Sbjct: 2123 KLRVRIEADEKKQLHIAEKLK----------ERERENDSLKDKVENLERELQMSEENQE- 2171
Query: 915 VPGWQAALLSLPGITNREAKKSRLPILIKP-SRSLG----NMYRLPATQEVVT----QLQ 965
L + N +A+ L I+ +RSL ++ L + +E +T + Q
Sbjct: 2172 --------LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ 2223
Query: 966 SQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQK 1025
Q+ EL L FK+ ++ Q I + E T + L N + A G+Q+
Sbjct: 2224 GQLSELDKLLSSFKSLLEEKEQAEI---QIKEESKTAVEMLQNQLKELNEAVAALCGDQE 2280
Query: 1026 GIKTTSSVWRDKEMDSDQQRSYEIDS-----EICPPDDLASLPSCKENPEDVLSPTSVAT 1080
+K T D ++ + Q I+ E L L KE+ A
Sbjct: 2281 IMKATEQSL-DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHH-------AD 2332
Query: 1081 YLSSKSQP-SAKVSVMGTDQS----ESINTSNETEYLKQKIHDLETELEGYQNFIFQLQK 1135
L + + ++ + T+Q E+ N+ E E LK KI + L G +
Sbjct: 2333 LLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL------- 2385
Query: 1136 HSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKH-----VKILGPLA 1190
++T+ E + L K + E+ SS + K +K A
Sbjct: 2386 ------DVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 1191 PEMIDSRVLENLKQQL----EEQEYKLQKEQNLNMQL-------------FSEIHN---- 1229
EM+ ++ L+ L +++ +QE KEQNL+ Q+ E N
Sbjct: 2440 MEMLQTQ-LKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIV 2498
Query: 1230 LQNKFRDLSPPRYDSL--VQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA 1287
LQ+ L D ++ + E+S + QI+D + Q E+ L+
Sbjct: 2499 LQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLEL 2558
Query: 1288 SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLL 1347
++ + + Q ++ A L + LE L + K N +NEL E + D +++ +
Sbjct: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYK------NLENEL-ELTKMDKMSFVEKV 2611
Query: 1348 PESPEPSASHALSDYETS-EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLR 1406
+ ++ ET ++ QK E+ S N + +L + ++EI++ +
Sbjct: 2612 ---------NKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL-LEEIKSSK 2661
Query: 1407 KRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAML 1466
+L+E N +L+K L+ + V+ + +E L H K++QAL L
Sbjct: 2662 DQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRL----HEAEKKHQAL---L 2714
Query: 1467 IKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ----------------- 1509
+ ++ + E RE L+ K L + E +K E L
Sbjct: 2715 LDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
Query: 1510 ----KEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYE 1565
K ++ ++ N++ +++ + +++EE ++ Q+ LSQ + +
Sbjct: 2775 MDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDT 2834
Query: 1566 KLDE---EHRRLREASGEGWKGQDPFRDLH-SLLMEIQALRLQLERSIETSSTLQSRLKE 1621
K+DE E + L+E E K D + D + SLL+ + L E + L S+ +
Sbjct: 2835 KVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSK 2894
Query: 1622 QLARGA 1627
Q +RG+
Sbjct: 2895 QDSRGS 2900
Score = 79.7 bits (195), Expect = 2e-14
Identities = 177/829 (21%), Positives = 357/829 (43%), Gaps = 178/829 (21%)
Query: 49 EETVSPTRAR--------NMKDFENQ-----ITELKKENFNLKLRIYFLEERMQQEFHGP 95
E+ V+P+R+ N F+N + +LK +N L+ +I LE R+Q
Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308
Query: 96 TEHIYKTNIELKVEVESLKRELQEREQLLIKA-SKAVESLAE---------AGGSEIQRV 145
+ K EL++++E K EL E+E++L K + V + A+ A +++++
Sbjct: 309 KGQVNKFQ-ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL 367
Query: 146 KEDARKKVQQVEDL---LTKRILLLEKDVTAAQAELEKAFAGTETEKA-LRLRLESKLSE 201
ED + Q E L ++I EK+ + +++F + E ++ RL +L +
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 202 MKKMH---EGDL-AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV--- 254
K MH + +L + V + + +EE K L E Q + +++++ E +
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 255 -------SSGELRGLCAAPREEKE-----RETEAAQMEHQKERNSFEERIQALEEDLREK 302
S + R +C E K +++ E + + S E ++ L+E + ++
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 303 EREIATEK---------------KNSLKR---------------DKAIQGLTMALKSKEK 332
E + EK ++ LK+ +K + L AL+ K+K
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
Query: 333 KVEEL----------NSEIEKLSAAFAKAREALQK--------AQTQEFQGSEDYE---T 371
+ EEL SE EKL +E LQ +TQ+ + E E T
Sbjct: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 667
Query: 372 ALSGKEALSAALRS-QNLTKSTENHRLRRSIKKITQELS--DLQQERE----RLEKDLEE 424
+E LS +R+ N+ S +S++ TQ+L+ +LQQ+ E + +K++E
Sbjct: 668 LEMDRENLSVEIRNLHNVLDS-------KSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRY------KSLLSESNKKLHNQEQV 478
+ S+ + DL ++++ L NE+ ++++ ++ + + LL + L E
Sbjct: 721 MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 479 IKHLTESTNQKDVLLQKF-----NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533
+ L + +Q+ + F + + + C L A D ++ ++ + S +
Sbjct: 781 QRSLL-AFDQQPAMHHSFANIIGEQGSMPSERSECRLEA--DQSPKNSAILQNRVDSLE- 836
Query: 534 PGSKTIFSKEKKQSSDY----EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA 589
+K+ +SD EEL+Q+ + +I +L+K+ Q S AE ++ +
Sbjct: 837 ----FSLESQKQMNSDLQKQCEELVQI---KGEIEENLMKAEQMHQS---FVAETSQRIS 886
Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSD--QTSYLSIC-LEENNRFQVE 646
+L++D ++QN+ + E +S + +E+E L +D +T I L+++N +
Sbjct: 887 ---KLQEDTSAHQNV---VAETLSALENKEKE-LQLLNDKVETEQAEIQELKKSNHLLED 939
Query: 647 HFSQEEL--------KKKVSDLIQL----VKELYTDNQHLKKTIFDLSCMGFQGNGFPDR 694
+ +L KK++S +I L ++EL +N LK+ L+ ++
Sbjct: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN---------QEK 990
Query: 695 LASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGG 743
+ +++E A+ DE + I+ LSDQ+ Q+ +++ + G
Sbjct: 991 MNLIQKSESFANYIDE------REKSISELSDQYKQEKLILLQRCEETG 1033
Score = 73.6 bits (179), Expect = 2e-12
Identities = 368/1933 (19%), Positives = 723/1933 (37%), Gaps = 340/1933 (17%)
Query: 64 ENQITELK----KENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
+N++ +LK KE+ ++ F EER Q +EL+ ++L+ E+ +
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLM-----------LELETVQQALRSEMTD 1116
Query: 120 REQLLIKASKAVESLAEAGG--SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAE 177
+ S +EAGG EI +KE+ K ++V DLL + L++ T + +
Sbjct: 1117 NQN---------NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ 1167
Query: 178 LEKAFAGTETEKALRLRLESKLSEMKKMH---EGDLAMALV-LDEKDRLIEELKLSLKSK 233
E+E +R ++ + SE + + + DL + + LD + + +L+ L++K
Sbjct: 1168 ------NLESEP-IRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNK 1220
Query: 234 EALIQ-------CLKEEKSQMACPDE-----NVSSGELRGL--CAAPREEK--------- 270
E +Q CL+ E + E ++ S E+ GL C EEK
Sbjct: 1221 ELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280
Query: 271 --ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328
+ + Q Q N E ++ + E L+ ++ E+ TE +S R + I A +
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNE-LEKICEILQAEKYELVTELNDS--RSECIT----ATR 1333
Query: 329 SKEKKVEELNSEIEKLSAAFAKAR-EALQKAQTQEF--QGSEDYETALSGKEALSAALRS 385
++V +L +E++ L+ E ++ EF Q +E + +L+
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAP---------- 1383
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
L +S L S K++ ++LQ++ L+ + + H + + + +L+ V+
Sbjct: 1384 --LDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDS 1441
Query: 446 LRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ 505
L+ E + N L+ E L +E ++ L+ S L +
Sbjct: 1442 LKAENLVLSTNLRNFQGDLVKEMQLGL--EEGLVPSLSSSCVPDSSSLSSLGDSSF---- 1495
Query: 506 QNCYLMAAEDLELRS--EGLITEK--------CSSQQPPG--SKTIFSKEKKQSSDYEEL 553
L D+ L S EG ++ CSS Q K S K + E L
Sbjct: 1496 YRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESL 1555
Query: 554 IQVLKKEQDIYTHLVKSLQESDSINNLQA-ELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
+V ++ + L + ++ + N + EL ++ + +Q E D L Q L
Sbjct: 1556 CEVYRQSLE---KLEEKMESQGIMKNKEIQELEQLLSSERQ-ELDCLRKQYLS------- 1604
Query: 613 SEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQ 672
E E + Q S+ LE ++ E E+L L +
Sbjct: 1605 ------ENEQW-----QQKLTSVTLEMESKLAAEKKQTEQLS------------LELEVA 1641
Query: 673 HLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQS 732
L+ DLS G D + ++ ++ + +T + +++ + D+ QQ
Sbjct: 1642 RLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQ- 1700
Query: 733 NEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792
++ D+ K + G ++ T +C G +P E P +K E
Sbjct: 1701 -DLNLDIEKI-TETGAVKPT----GECSGEQSPDTNYE--------PPGEDKTQGSSECI 1746
Query: 793 PDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF---SKPHDEL 849
+L L+ FL QE +L + ++T + L+H ++ S ++
Sbjct: 1747 SELSFSGPNALVPMDFLGNQE-DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMK 1805
Query: 850 KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRP 909
+L + L + + K+ +A ++ G+L + + + + S +H+
Sbjct: 1806 ELDSKLHLQEVQLMTKI---EACIELEKIVGELKKENSDLSEKL-------EYFSCDHQE 1855
Query: 910 ENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS--RSLGNMYRLPATQEVVTQLQSQ 967
L + E S L + S +G+ +V + +
Sbjct: 1856 --------------LLQRVETSEGLNSDLEMHADKSSREDIGDN-----VAKVNDSWKER 1896
Query: 968 ILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGI 1027
L+++ EL ++ + + + EA +E T +K L +D+ +QK I
Sbjct: 1897 FLDVENELSRIRSEKASIEHEALYLEADLEVVQT-EKLCLE---------KDNENKQKVI 1946
Query: 1028 KTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPS-CKENPEDVLSPTSVATYLS--S 1084
+ +Q R E+D+ L L KE +++ S S + +
Sbjct: 1947 VCLEEELSVVTSERNQLRG-ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA 2005
Query: 1085 KSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY-------QNFIFQLQKHS 1137
+++ K ++ T S+ + +L++K+ LE + + +N I QL K
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
Query: 1138 QC----SEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS--------SLHQVRYVKHVKI 1185
+ SE++ L ++ + +SK + E+ F+ +HQ+R
Sbjct: 2066 ELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 1186 LGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYD-- 1243
+ A E + E LK++ E + K +NL +L N + D + +
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVE 2185
Query: 1244 ---SLVQSQARELSLQR--------------QQIKDGHGICVISRQHMNTMIKAFEELL- 1285
+ ++ AR L + +QI++ G ++ ++ +F+ LL
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQG----QLSELDKLLSSFKSLLE 2241
Query: 1286 -------QASDVDYCVAEGFQEQLNQCAELLEKL----EKLFLNGKSVGVEMNTQNELME 1334
Q + E Q QL + E + L E + +S+ + +++L
Sbjct: 2242 EKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRN 2301
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEK-SFFSRDQKQDNETEKTSVMVNSFSQD 1393
IE+ E+ E L + SE + + + ++ E E N
Sbjct: 2302 SIEKLRARL-----EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
Query: 1394 LLMEHIQ-EIRTLRKRLE---ESIKTNE----KLRKQLERQGSEFVQGSTSIFASGSELH 1445
L E+ + E+ TL+ ++E +S++ E +R + E +E + I SEL
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI----SELE 2412
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
+S + L+++ Q M K S + +L+E R V+ H +E KE+N
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNER--VAALHNDQEACKAKEQN 2470
Query: 1506 ERLQKE-----------GSEKERHN--------QQLIQEVRCSGQELSRVQEEVKLRQQL 1546
Q E G ++ ++N LIQEV Q+L + EE+ +
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQ 2530
Query: 1547 LSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLE 1606
+ ++L+ L ++ E++ LR + E L + +Q+ L+
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE----------LEQKIQVLQSKNASLQ 2580
Query: 1607 RSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNS 1666
++E + L+ +L K + + V ++ E LQ + H+ + E
Sbjct: 2581 DTLEVLQSSYKNLENELE--LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638
Query: 1667 FDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRH 1726
+ A + + E S + L+ ++ S C+ H K G+
Sbjct: 2639 LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM------HKDQVEKEGK- 2691
Query: 1727 VLGLIEDYEALLKQISQGQRLLA-------EMDIQTQEAPSSTSQELGTKGPHPAPLSKF 1779
V I +Y+ L + + + L E++IQT ++ +E LS
Sbjct: 2692 VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEEC---------LSSQ 2742
Query: 1780 VSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1839
+ K + EE LK ++ E++ + K + K +L ++ ++
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQI-----------LEELKKTKMDNLKYVNQLKKENERA 2791
Query: 1840 QNTMKLLQLSKRQ 1852
Q MKLL S +Q
Sbjct: 2792 QGKMKLLIKSCKQ 2804
Score = 45.8 bits (107), Expect = 4e-04
Identities = 81/385 (21%), Positives = 158/385 (41%), Gaps = 38/385 (9%)
Query: 1190 APEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQ 1247
+P ++D +N L+ ++ E E +LQ + E+ NKF++L + V+
Sbjct: 276 SPHLLDQLKAQNQELRNKINELELRLQGHEK-------EMKGQVNKFQELQLQLEKAKVE 328
Query: 1248 SQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDY-CVAEGFQEQLNQCA 1306
+E L + +D +T A E+ L+ D C + +
Sbjct: 329 LIEKEKVLNK--CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
Query: 1307 ELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQ-HLLPESPEPSASHALSDYETS 1365
+ +++ EK F E++ Q + ++++ + + L E + H + E
Sbjct: 387 QKIKEKEKEFQE------ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD 440
Query: 1366 EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425
+ + S Q+ +N E+ + Q I+E LR+ +EE K N L+ E+
Sbjct: 441 KLT--SVKQQLENNLEEFKQKLCRAEQAFQASQIKE-NELRRSMEEMKKENNLLKSHSEQ 497
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHF---LRKQNQALNAMLIKGSRDK--QKENDKL 1480
+ E + A + L +F ++ +N + ML + ++K Q+EN
Sbjct: 498 KAREVCH----LEAELKNIKQCLNQSQNFAEEMKAKNTSQETML-RDLQEKINQQENSLT 552
Query: 1481 RESLSRKTVSLEHLQREYAS---VKEEN--ERLQKEGSEKERHNQQLIQEVRCSGQELSR 1535
E L LE QR+ + K E+ E+L + S+ E+ ++ L+ + +E
Sbjct: 553 LEKLKLAVADLEK-QRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEE 611
Query: 1536 VQEEVKLRQQLLSQNDKLLQSLRVE 1560
++EE L S+N+KLL + E
Sbjct: 612 LKEEKTLFSCWKSENEKLLTQMESE 636
Score = 44.7 bits (104), Expect = 9e-04
Identities = 78/389 (20%), Positives = 171/389 (43%), Gaps = 36/389 (9%)
Query: 1200 ENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQAR---ELSLQ 1256
+ L+ QLE+ + +L +++ + + E+ ++ D + +Y +L Q + +LS Q
Sbjct: 316 QELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY-DQASTKYTALEQKLKKLTEDLSCQ 374
Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLF 1316
RQ + C + Q + K F+E L + + QE + A L ++L++
Sbjct: 375 RQNAESAR--CSLE-QKIKEKEKEFQEELSRQQRSFQTLD--QECIQMKARLTQELQQAK 429
Query: 1317 LNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376
+ E++ + +++E + ++ L + + + + + E ++
Sbjct: 430 NMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENEL---------RRS 480
Query: 1377 DNETEKTSVMVNSFSQDLLME--HIQ-EIRTLRKRLEESIKTNEKLRKQLERQGSEFVQG 1433
E +K + ++ S S+ E H++ E++ +++ L +S E+++ + Q +
Sbjct: 481 MEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL 540
Query: 1434 STSIFASGSELHSSLTSE-----IHFLRKQNQALNAMLIKGSRDKQKENDKLR--ESLSR 1486
I ++ +SLT E + L KQ +L K ++ NDKL E S+
Sbjct: 541 QEKI----NQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESK 596
Query: 1487 KTVS-LEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ 1545
+S LE ++EY +KEE SE E+ Q+ E +++ ++ +K +Q
Sbjct: 597 ALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQI 656
Query: 1546 LLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
+ ++ +++L ++ E L E R L
Sbjct: 657 KSHEYNERVRTLEMD---RENLSVEIRNL 682
Score = 42.0 bits (97), Expect = 0.006
Identities = 53/277 (19%), Positives = 113/277 (40%), Gaps = 34/277 (12%)
Query: 1455 LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSE 1514
L + + L ++ ++ + + DKL++ ++ L+ L+ K++ E + EG+
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL 1574
+R NQ+L++ + ++ E+++++ ++ + L S + K EKL++E +R
Sbjct: 65 LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK---KQIEKLEQELKRC 121
Query: 1575 R---EASGEGWKGQD----PFRDLHSLL------------MEIQALRLQLERSIETSSTL 1615
+ E S + + D P + + + L+ + + +E L
Sbjct: 122 KSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRL 181
Query: 1616 QSRLKEQLARGAEKAQEGAL----TLAVQAVSIPEVPLQPDK------HDGDKYPMESDN 1665
++ +K A+ A + A +A S Q +K + + P+ D
Sbjct: 182 EAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 1666 SFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSS 1702
S F Q VTP T + D +S D+ SS
Sbjct: 242 SASYFSGEQEVTPS--RSTLQIGKRDANSSFFDNSSS 276
Score = 33.1 bits (74), Expect = 2.6
Identities = 62/287 (21%), Positives = 115/287 (40%), Gaps = 38/287 (13%)
Query: 1354 SASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHI----QEIRTLRKRL 1409
SAS+ + E + SR Q + + S ++ S L++ + QE+R L
Sbjct: 242 SASYFSGEQEVTP----SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINEL 297
Query: 1410 EESIKTNEK-----------LRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQ 1458
E ++ +EK L+ QLE+ E ++ + EL + T++ +
Sbjct: 298 ELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT-TAQYDQASTK 356
Query: 1459 NQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERH 1518
AL L K + D + R++ SLE +KE+ + Q+E S ++R
Sbjct: 357 YTALEQKLKKLTEDLSCQ----RQNAESARCSLEQ------KIKEKEKEFQEELSRQQRS 406
Query: 1519 NQQLIQE-VRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREA 1577
Q L QE ++ + +Q+ + L ++ DKL V+ + L+E ++L A
Sbjct: 407 FQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTS---VKQQLENNLEEFKQKLCRA 463
Query: 1578 ----SGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
K + R + + E L+ E+ L++ LK
Sbjct: 464 EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK 510
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 117 bits (294), Expect = 8e-26
Identities = 330/1653 (19%), Positives = 645/1653 (39%), Gaps = 274/1653 (16%)
Query: 59 NMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ 118
N K+ E Q+ E ++E +K ++ + QQ+ +EL+ E + L+ E+
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKI-----------LELEEENDRLRAEVH 1704
Query: 119 EREQLLIKASKAVESLAEAGGS---EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
A + +E+L + S E++RVK + ++ + L++++ L E+
Sbjct: 1705 PAGDT---AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEE-----V 1756
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA 235
+L+ G +++A E ++ EG ++ +E+D LS+ ++
Sbjct: 1757 QDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQD------SLSMSTRPT 1810
Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQAL 295
+ + KS A P K+ + + ++ + +ERI L
Sbjct: 1811 CSESVPSAKS------------------ANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852
Query: 296 EEDLREKERE----IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKA 351
EE+ ++K +E + EK L + G L+ + K+ LN +I++ + K
Sbjct: 1853 EEE-KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKL 1911
Query: 352 REALQKAQTQEFQGSEDYETALSG------KEALSAALRSQNLTKSTENHRLRRSIKKIT 405
+E ++ + + + L+G ++ A ++++ L +N L++ + ++
Sbjct: 1912 KETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN--LKKCVSELE 1969
Query: 406 QELSDLQQERERLEKDLEEAHREKSKG--------------DCTIRDLRNEVEKLRNE-- 449
+E L +E+ ++E ++ + + EK +G +++ + EV++L+ +
Sbjct: 1970 EEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 450 -VNEREKAMENRYKSL---LSESNKKL----HNQEQVIKHLTESTNQK---DVLLQKFNE 498
E+ A+E K+L +ES K L N Q ++H ++ + VLL
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEK--KQSSDYEELIQV 556
+ V+ N L ++L+ E + ++ + + ++EK K+ + +E +
Sbjct: 2090 EAARVLADN--LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2147
Query: 557 LKKEQ--------DIYTHLVKSLQESDSI-NNLQAELNKIFALRK---QLEQDVLSYQNL 604
L++E+ +I L K +E + NL + + ++ A K L+ D +
Sbjct: 2148 LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
Query: 605 RKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLV 664
K E + S+ + +EE L D S L L + + EELK +S L +
Sbjct: 2208 AKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMS------IHMEELKINISRL-EHD 2260
Query: 665 KELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFL 724
K+++ + + C QG + L+ E+T L + K+ + E+ L
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGEN-KELLSQLEETRHLYHSSQNELAKL--ESELKSL 2317
Query: 725 SDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISD------------------CDGAHAPG 766
DQ SN + K + G G +R E+ I + H
Sbjct: 2318 KDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377
Query: 767 CLEEGAFINLLAPLFNEKATLLLESRPDLLKVVREL--LLGQ-----LFLTEQEVSG--- 816
++E I+LL+ + E R K ++EL LL Q + L E+
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
Query: 817 -----EHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E L ++ +QK +L FV++ S S +D ++ + Q ++ + + KD
Sbjct: 2438 TNQLMETLKTIKKENIQQKAQLDSFVKSMS-SLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Query: 872 SVQTVATEGDLLRFKHEATREAWEE-KPINTALSAE--HRPENLHGVPGWQAALLSLPGI 928
+Q A E + L+ + R ++ N L AE E+L+ V I
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV------------I 2544
Query: 929 TNREA-KKSRLPILIKPSRSLGNMY-----RLPATQEVVTQLQSQILELQGELKEFKTCN 982
T +++ +K L + ++ ++ L N Y +L ++E L+ LQ E
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE-------- 2596
Query: 983 KQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSD 1042
KQ K I + V + T T L + +G + +++ + S+++ S
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALF-----SSS 2651
Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSES 1102
Q+R E++ E+++ A + + K +
Sbjct: 2652 QKRIAELE-------------------EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG 2692
Query: 1103 INTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAII--------TVLCGTEGAQ 1154
I NETE ++++ +L +L + + + K ++ A I ++ + A
Sbjct: 2693 I-MRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVK--ILGPLAPEMIDSRV-----LENLKQQLE 1207
+ L + K D + L + + + +L A M + LE L QQL
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
Query: 1208 EQEYKL-----QKEQNLN-MQLFSE-IHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
++ +L Q E + N +Q FS+ + +LQN+ L ++ L + + E QR
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL----WNELEKFRKSEEGKQRSAA 2867
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
+ S + ++ KA L D + Q+Q Q + + +L L +
Sbjct: 2868 QPS-----TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQ 2922
Query: 1321 SVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNET 1380
+ + E + ++NL++QH L + +S + + E+ + K
Sbjct: 2923 EYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK----- 2977
Query: 1381 EKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFAS 1440
D + H+Q L + L S + L+ Q +RQ S TS
Sbjct: 2978 ------------DQQLSHLQ---NLIRELRSSSSQTQPLKVQYQRQASP----ETSASPD 3018
Query: 1441 GSELHSSLTSEIHFLRKQ-NQALNAMLIKGSRDKQ---------KENDKLRESLSRKTVS 1490
GS+ +L E LR Q N +L + K R +Q +E + L L + S
Sbjct: 3019 GSQ---NLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQS 3075
Query: 1491 LEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQ-----EEVKLRQQ 1545
L Q+ Y + L+K+ E + I + QE + V EE++ QQ
Sbjct: 3076 LRENQQHYGDLLNHCAVLEKQVQELQA-GPLNIDVAPGAPQEKNGVHRKSDPEELREPQQ 3134
Query: 1546 LLSQNDKLLQSLRVELKAYEKLDEEHRRLREAS 1578
S+ + L + R E+ KL EE R R A+
Sbjct: 3135 SFSEAQQQLCNTRQEVNELRKLLEEERDQRVAA 3167
Score = 114 bits (285), Expect = 9e-25
Identities = 395/1983 (19%), Positives = 777/1983 (39%), Gaps = 291/1983 (14%)
Query: 84 LEERM--QQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAG-GS 140
LEE++ +++F + + +T + +++ L+ E+ E + ++ K + S +A G
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAII---QKLITSNTDASDGD 1136
Query: 141 EIQRVKEDA------RKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGT--------E 186
+ VKE + + L ++IL LEK+ Q +L++A E
Sbjct: 1137 SVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE 1196
Query: 187 TEKALRL----------RLESKLSEMKKMHE--GDLAMALVLDEKDRLIEELKLSLKSK- 233
E+ LR RL+ + E K +E GD L + ++ + +L + + +
Sbjct: 1197 KERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQES 1256
Query: 234 --------EALIQCLKEEKSQMA-----CPD---ENVSSGELRG---LCAAPREEKERET 274
E L + ++ +Q CPD + + L+G + + KE E
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 275 EAAQMEHQKERNSFE-----ERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKS 329
E ++E + + E E + L+E + ++ EI + K S + + + L L+S
Sbjct: 1317 EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLES 1376
Query: 330 KEKKV------EELNSEIEKLSAAFAKAREALQ--KAQTQEFQGS-EDYETALSGKEALS 380
+ ++ EL ++++L +K E + Q E + + +T + +E L
Sbjct: 1377 SQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI 1436
Query: 381 AALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTI---R 437
AL +Q L + H R IK++ EL +++Q+ E + ++ + + K + +
Sbjct: 1437 KALHTQ-LEMQAKEHDER--IKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493
Query: 438 DLRNEVEKLRNEVNEREKAMENRYKSLLS-ESNKKLHNQEQ--VIKHLTESTNQKDVLLQ 494
+ E + L+ E++ +E KSL ES N+E+ V+ L ++D L+
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI- 1552
Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
E D +++ + E L+L EGL +K + +++ S + +S++++E
Sbjct: 1553 --TEMDRSLLENQSLSSSCESLKLALEGLTEDK--EKLVKEIESLKSSKIAESTEWQEKH 1608
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT------- 607
+ L+KE +I LQ ++++N + + +Q +Q++ Y LR T
Sbjct: 1609 KELQKEYEIL------LQSYENVSNEAERIQHVVEAVRQEKQEL--YGKLRSTEANKKET 1660
Query: 608 ---LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQ-------------- 650
L+E E+ +E+ + + EEN+R + E
Sbjct: 1661 EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720
Query: 651 --------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPD-RLASTEQT 701
E +K + L + + L ++ L + + DL +GN L +TE+
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ-IEGNVSKQANLEATEKH 1779
Query: 702 ELLASKEDEDTIKI-GEDDEINFLSDQHLQQSNE-----------IMKDLSKGGCKNGYL 749
+ + +E T I GE +E + LS +E + KD S N YL
Sbjct: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYL 1839
Query: 750 RHTESKISDCDGAHAPGCLEEGAFIN--LLAPLFNEKATLL--LESRPDLLKVVRELLLG 805
+ + G LEE N L NEK TLL + ++ LK+++E +
Sbjct: 1840 QQIDQLKERIAG------LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893
Query: 806 QLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPK 865
L +Q K ++T +++ + + N ++ + + C+
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ----------- 1942
Query: 866 VGLKDASVQTVATEGDLLRFKHEATREAWEEKPI----NTALSAEHRPENLHGVPGWQAA 921
+ DA ++ E ++ K + E EEK T + +E R E L + G Q
Sbjct: 1943 -DVTDAQIKNELLESEMKNLK-KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000
Query: 922 LLSLPGITNREAKKSRLPILIKPSRSLGNMYR--------LPATQEVVTQLQSQILELQG 973
PG N+ K +L + + + + + + A + V L+ E Q
Sbjct: 2001 ----PG--NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
Query: 974 ELKEFKTCNKQL--HQKLILAEAVMEGRPTPDKTLLN-AQPPVGAAYQDSPGEQKGIKTT 1030
+L+ K Q H+K AE K LL+ Q D+ +K +++
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASF------KVLLDDTQSEAARVLADNLKLKKELQSN 2108
Query: 1031 SSVWRD--KEMDSDQQRSYE------IDSEICPPDDLASLPSCKENPEDVLSPTSVATYL 1082
+ K+ D D +R E + + + L +L K + E+ + V
Sbjct: 2109 KESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNK 2168
Query: 1083 SSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQ---C 1139
K + ++ T + T + + + ++ + + F +Q +
Sbjct: 2169 KDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRL 2228
Query: 1140 SEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP--LAPEMIDSR 1197
E +VL +D L + + ++ S L + + K L ++ D+
Sbjct: 2229 KEDNCSVL------KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL 2282
Query: 1198 VLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSL 1255
EN L QLEE + QN +L SE+ +L+++ DLS +SL + + ++ +L
Sbjct: 2283 QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLS----NSLEKCKEQKGNL 2338
Query: 1256 Q---RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE--------GFQEQLN- 1303
+ RQQ D S + + T ++A EL + + E G +E +
Sbjct: 2339 EGIIRQQEADIQN-SKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQV 2397
Query: 1304 QCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYE 1363
AEL ++ +K E+ L+ + EE+N+ + ++ + + + +
Sbjct: 2398 AIAELRQQHDK----------EIKELENLLSQEEEENIVLEEENKKAVD-KTNQLMETLK 2446
Query: 1364 TSEKSFFSRDQKQDNETEKTSVMVNSFS------QDLLMEHIQEIRTLRKRLEESIKTNE 1417
T +K + + D+ + S + N Q L H+ I + ++E+ N
Sbjct: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506
Query: 1418 KLRKQ---LERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQ 1474
KL+++ L + + + A + L I Q + L + ++ +++ +
Sbjct: 2507 KLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELE 2566
Query: 1475 KENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE-- 1532
+ KL E L + E L+R + +++EE + L KE + QL ++V +E
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Query: 1533 -------LSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQ 1585
L +EEV L S + K + L EL +K EA+ + + +
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQK---------EAAKKVGEIE 2677
Query: 1586 DPF-RDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEG-ALTLAVQAVS 1643
D ++L L + +R + E + E + L L E + +E LT +Q+
Sbjct: 2678 DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737
Query: 1644 IPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSA 1703
LQ + ++ E +D ++ + + L + D+L ++ S
Sbjct: 2738 RSMSSLQNSRDHANEELDELKRKYD-----ASLKELAQLKEQGLLNRERDALLSETAFSM 2792
Query: 1704 TSTP--CVSRLVTGHHLWASKNGR--HVLGLIEDYEALLKQISQGQRLLA-EMDIQTQEA 1758
ST +S L + SK+ + H+ +ED ++ S+ L E D E
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852
Query: 1759 PSSTSQELGTK--GPHPAPLSKFVSSVSTAKLTLE-EAYRRLKLLWRVSLPEDGQCPLHC 1815
E G + P+ V S+ A +L+ + R LK L +
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ----------- 2901
Query: 1816 EQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKI--LRKARGN 1873
+Q ++ E+T+LH L Q ++ Q+ K Q+ QE++ + L H++ LR + +
Sbjct: 2902 QQYLQINQEITELH-PLKAQLQEYQDKTKAFQI--MQEELRQENLSWQHELHQLRMEKSS 2958
Query: 1874 LEL 1876
E+
Sbjct: 2959 WEI 2961
Score = 103 bits (256), Expect = 2e-21
Identities = 368/1921 (19%), Positives = 737/1921 (38%), Gaps = 257/1921 (13%)
Query: 101 KTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLL 160
K++ E ++E+E +K +LQE+E+L+ S L +A + + + + V + L
Sbjct: 137 KSSTEEEMEIEKIKHKLQEKEELI---STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQ 193
Query: 161 TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH-----EGDLAMALV 215
K + +Q + E+A EK R + +L E + + + + M
Sbjct: 194 EKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQK 253
Query: 216 LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSS---------GELRGLCAAP 266
L R +EE + SL + ++ L++E + ++ +S LR
Sbjct: 254 LRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 267 REEKERETEAAQMEHQKERNSF----EERIQALEEDLREKEREIATEKKNSL---KRDKA 319
REE + E ++E + + SF EE LE+ + + + E + S K
Sbjct: 314 REESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373
Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAKA-----REALQKAQT------QEFQGSED 368
++ T + S +K +EL S + L +K +A+Q AQT Q Q S++
Sbjct: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE 433
Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLR----RSIKKITQELSDLQQERERL---EKD 421
L+ SQ N + +I + + + +L+ E+ L +
Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 422 LEE--AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
LEE A EK T+ + +N + EV+E S++ +NK+ + E+
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSE---------ISIVDIANKRSSSAEESG 544
Query: 480 KHLTEST-----NQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPP 534
+ + E+T + VLL + E E+ L E E L ++ +
Sbjct: 545 QDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 535 G----SKTIFSKEKKQS----SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNK 586
G +F ++ Q + E + ++KEQ H ++ +E S+N+ EL
Sbjct: 605 GIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI-SLNDAGVELKS 663
Query: 587 IFALRKQLEQDVLS--------YQNLRKTLEEQISEIRRREEESFSLY-------SDQTS 631
KQ LS +Q+ + L+ QI E+ ++ +Y + + S
Sbjct: 664 ----TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEIS 719
Query: 632 YLSICLEE------NNRFQVEHFSQE--ELKKKVSDLIQLVKELYTDNQHLKKTIFDLS- 682
L+ +EE NN S+E +L +V +L +V EL + L+ + +
Sbjct: 720 NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL-SMVTELRAQVKQLEMNLAEAER 778
Query: 683 --CMGFQGNGFPDRLASTEQTELLASKEDEDTIKIG------EDDEINFLSDQHLQQSNE 734
+ ++ D L TEQ L+ + +KI +D ++ F L +S +
Sbjct: 779 QRRLDYESQTAHDNLL-TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ 837
Query: 735 IMKDLSKGGCKNG--YLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL---LL 789
+ G +RH SK+ + A + LE LL + TL +
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIE 897
Query: 790 ESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDEL 849
E + ++ + + L E++ S G KT K++ L+ + + ++
Sbjct: 898 EKDQQVTEISFSMTEKMVQLNEEKFS----LGVEIKTLKEQLNLLSRAEEAKKEQVEEDN 953
Query: 850 KLSCEA-----QLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALS 904
++S ++ AG++ K L+ E DLL+ ++E + + IN
Sbjct: 954 EVSSGLKQNYDEMSPAGQISKEELQH--------EFDLLKKENEQRKRKLQAALIN---- 1001
Query: 905 AEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPIL---------IKPSRSLGNMYRLP 955
R E L V + L +L ++ K +P+ K ++
Sbjct: 1002 ---RKELLQRVSRLEEELANL-----KDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053
Query: 956 ATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGA 1015
QE+ L+ I E + EL+ + K L +KL E ++TL + +
Sbjct: 1054 KCQEIEIYLKQTISEKEVELQHIR---KDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL 1110
Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSP 1075
+ Q I+ + D D D + I PP +S E E +L+
Sbjct: 1111 LQAEISENQAIIQKLITSNTDAS-DGDSVALVKETVVISPPCTGSSEHWKPELEEKILAL 1169
Query: 1076 TSVATYLSSKSQP--SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY----QNF 1129
L K Q +++ +++ Q + + E + K + L+ + + +N
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229
Query: 1130 IFQL-QKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188
QL Q Q E+I L T+ + S P G + + H + V +
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTP--GLEEPLFKATEQHHTQPVLESNLCPD 1287
Query: 1189 LAPEMIDSRVLE------NLKQQLEEQE--------------YKLQKEQNLNMQLFSEIH 1228
D+ L+ +K QL+E E +L K+ QL +I+
Sbjct: 1288 WPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347
Query: 1229 NLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTM---IKAFEELL 1285
+ L +++ V +++ + L+ Q++ + +H+ + + ++L+
Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ------IAGLEHLRELQPKLDELQKLI 1401
Query: 1286 QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQH 1345
+ D G QL++ L K++ + + + ++TQ E+ + ++ +
Sbjct: 1402 SKKEEDVSYLSG---QLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ 1458
Query: 1346 L----LPESPEPSASHALSDYETSEK---SFFSRDQK-QDNETEKTSVMVNSFSQDLLME 1397
+ + + PE + + + K + SR + ++N++ + + + + + L +
Sbjct: 1459 VELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518
Query: 1398 HIQEIR-----------TLRKRLEESIKTNEKL-----RKQLERQGSEFVQGSTSIFASG 1441
+ ++ T+ RL + +KL R LE Q S + G
Sbjct: 1519 SLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEG 1578
Query: 1442 -SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS 1500
+E L EI L+ A + + ++ QKE + L +S + E +Q +
Sbjct: 1579 LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEA 1638
Query: 1501 VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE 1560
V++E + L + E + ++ ++++ + QE+ ++E K+R+ S+ K+L+
Sbjct: 1639 VRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE--KMRKFAKSKQQKILE----- 1691
Query: 1561 LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
L+EE+ RLR G + +LL +++ +LER TL + +
Sbjct: 1692 ------LEEENDRLRAEVHPA--GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 1621 EQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKS 1680
+ +++ +L+ VQ + ++ K + + DN ++ + P
Sbjct: 1744 SLM------SEKDSLSEEVQDLK-HQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 1681 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGH-----HLWASKNGRHVLGLIEDYE 1735
E LS + + S S+ ++ P VS+ + H +L + + +E+ +
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856
Query: 1736 ALLKQISQ---GQRLLAEMDIQTQEAPSSTSQELGTK-GPHPAPLSKFVSSVSTAKLTLE 1791
K+ SQ ++ I T++ QE TK + + +S V+ K T E
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
Query: 1792 EAYRRLKLLWRVSLPE-DGQCPLHCEQIGE-------MKAEVTKLHKKLFEQEKKLQNTM 1843
E L+ L E +G +C+ + + +++E+ L K + E E++ Q +
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976
Query: 1844 K 1844
K
Sbjct: 1977 K 1977
Score = 96.7 bits (239), Expect = 2e-19
Identities = 374/1949 (19%), Positives = 757/1949 (38%), Gaps = 312/1949 (16%)
Query: 78 KLRIYFLEERMQQEFHGPTEHIYKTNIELKV-EVESLKRELQEREQLLIKASKAVESLAE 136
+L+ LE ++ FH E IY+ N++ K E+ +L + ++E ++ S A +L+E
Sbjct: 688 RLKSQILE--LELNFHKAQE-IYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSE 744
Query: 137 AGGSEIQRVKE-----DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKAL 191
+ +VKE + R +V+Q+E L + D E + A TE+
Sbjct: 745 ERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY-----ESQTAHDNLLTEQIH 799
Query: 192 RLRLESKLSEMK-KMHEGDLA-MALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMAC 249
L +E+K ++K ++ + +L + L E+ LI L+ L++KE+ + E ++
Sbjct: 800 SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS 859
Query: 250 PDENVSSGELRGLCAAPREEKERE-TEAAQMEHQKERNSFEERIQALEEDLREKEREIA- 307
E +S +KE E T+ Q+ +K+R+ ++ L++ + EK++++
Sbjct: 860 KVEELSQA---------LSQKELEITKMDQLLLEKKRD-----VETLQQTIEEKDQQVTE 905
Query: 308 -----TEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
TEK L +K G+ +++ L ++ LS A +E +++
Sbjct: 906 ISFSMTEKMVQLNEEKFSLGV---------EIKTLKEQLNLLSRAEEAKKEQVEEDNEVS 956
Query: 363 FQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDL 422
++Y+ + L+ + EN + +R ++ +L Q RLE++L
Sbjct: 957 SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL 1016
Query: 423 EEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHL 482
E K R EVE+ + EK + ++ + + + + +E ++H+
Sbjct: 1017 ANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHI 1076
Query: 483 TESTNQKDVLLQKFN------EKDLEVIQQNCYLMAAEDLELRS--EGLITEKCSSQQPP 534
+ +K ++F + L+ L+ AE E ++ + LIT +
Sbjct: 1077 RKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD-- 1134
Query: 535 GSKTIFSKE------------KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
G KE + + EE I L+KE++ L K LQE ++ + +A
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKE---QLQKKLQE--ALTSRKA 1189
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
L K + L +++ ++ L+EQ E + E DQ L I + E+
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN----IGDQLRQLQIQVRESID 1245
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLA---STE 699
++ Q+E L + + + T+ H + + C + + D A T
Sbjct: 1246 GKLPSTDQQESCSSTPGLEEPLFKA-TEQHHTQPVLESNLCPDWPSHS-EDASALQGGTS 1303
Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEI---MKDLSKGGCKNGYLRHTESKI 756
++ A ++ + K+ + +++ + + ++S E+ + ++K G + L+ T S
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK-TVSHE 1362
Query: 757 SDCDGAHAPGCLEEGAF-------INLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFL 809
++ LE + L P +E L+ + D+ + +L + L
Sbjct: 1363 AEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL 1422
Query: 810 T-------EQEVSGEHLDGKTEKTPKQKGELVHFVQTN--SFSKPHDEL--KLSCEAQLV 858
T EQE + L + E K+ E + +Q + +E+ + + Q+
Sbjct: 1423 TKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQ 1482
Query: 859 KAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRP--------- 909
+ + + K+A + + + +L + R + + +SA+++
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
Query: 910 ------------------ENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNM 951
EN ++ L+L G+T + K L+K SL +
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEK------LVKEIESLKSS 1596
Query: 952 YRLPAT--QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRP-------TP 1002
+T QE +LQ E + L+ ++ + + + + EAV + + +
Sbjct: 1597 KIAESTEWQEKHKELQK---EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST 1653
Query: 1003 DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASL 1062
+ + + A Q+ ++ ++ + + K ++ +++ + +E+ P D A
Sbjct: 1654 EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND-RLRAEVHPAGDTA-- 1710
Query: 1063 PSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETE 1122
KE E +LS + S K + T + + +E + L +++ DL+ +
Sbjct: 1711 ---KECMETLLSSNA-----SMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Query: 1123 LEG---YQNFIFQLQKH---SQCSEAIITVLCGTEGAQDGLS------------KPKNGS 1164
+EG Q + +KH + +E + G QD LS K+ +
Sbjct: 1763 IEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
Query: 1165 DGEEMTFSSLHQV-RYVKHVKILGPLAPEMIDSRV--LENLKQQLEEQEYKLQKEQNLNM 1221
FSS ++ Y++ + + + R+ LE KQ+ +E L+ E+N
Sbjct: 1823 PAVSKDFSSHDEINNYLQQI--------DQLKERIAGLEEEKQKNKEFSQTLENEKN--- 1871
Query: 1222 QLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAF 1281
L S+I + + ++Q + +++L QQI ++ ++ + K
Sbjct: 1872 TLLSQISTKDGELK---------MLQEEVTKMNLLNQQI----------QEELSRVTKLK 1912
Query: 1282 EELLQASDVDYCVAEGFQEQL-NQCAELLEKLEKLFLNGKSVG------VEMNTQNELME 1334
E + D +E+L NQ AE LNG S+G + +NEL+E
Sbjct: 1913 ETAEEEKD-------DLEERLMNQLAE---------LNG-SIGNYCQDVTDAQIKNELLE 1955
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL 1394
++ L E + K + + Q E S Q+L
Sbjct: 1956 SEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE--LQEL 2013
Query: 1395 LMEHIQEIRTLRK---RLEESIKTNEKLRKQLE---RQGSEFVQGSTSIFASGSELHSSL 1448
L E QE++ L+K R +E I E+ K LE + + ++ + A E
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 1449 TSEIHFLR-----KQNQALNAML--IKGSRDKQKENDKLRESLSRKTVSLEHL--QREYA 1499
+E+ + Q++A + +K ++ Q + ++ + +K LE Q E
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 1500 SVKEENERLQK-EGSEKER-HNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSL 1557
+KE+ +K + +E+ H ++ I E++ + L++ +EV QQL D + L
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVT---LNKKDKEV---QQLQENLDSTVTQL 2187
Query: 1558 RVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQS 1617
K+ L ++ R+ + E K + F D IQ+ ++ + S L+
Sbjct: 2188 AAFTKSMSSLQDDRDRVID---EAKKWERKFSD------AIQSKEEEIRLKEDNCSVLKD 2238
Query: 1618 RLK------EQLARGAEKAQEGALTLAVQAVSIPEVPLQP---DKHDGDKYPMES--DNS 1666
+L+ E+L + + +A + EV LQ D G+ + S + +
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQT--EVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 1667 FDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRH 1726
L+ SSQ K SE L TD S + C + +
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTD-------LSNSLEKC------------KEQKGN 2337
Query: 1727 VLGLIEDYEALLKQISQGQRLLAEMDIQ-TQEAPSSTSQELGTKGPHPAPLSKFVSSVST 1785
+ G+I EA ++ L E D+Q ++E S +E+ K K +S +S
Sbjct: 2338 LEGIIRQQEADIQNSKFSYEQL-ETDLQASRELTSRLHEEINMKE------QKIISLLSG 2390
Query: 1786 AKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKL 1845
+ ++ A L+ + E Q E + + +KK ++ +L T+K
Sbjct: 2391 KEEAIQVAIAELRQQHDKEIKELENL---LSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 1846 LQLSKRQEKVIFDQLVVTHKILRKARGNL 1874
++ Q+K D V + L+ R +
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Score = 78.6 bits (192), Expect = 5e-14
Identities = 302/1585 (19%), Positives = 601/1585 (37%), Gaps = 276/1585 (17%)
Query: 174 AQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE---KDRLIEELKLSL 230
A L + +T++ +R L+ +L + M + V + ++L+ ELK +
Sbjct: 9 ANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDII 68
Query: 231 KSKEALIQ----CLKEE---------------KSQMACPDENVSSGELRGLCAAPREEKE 271
+ K+ +Q L+EE K+++ ++ + + +G P E +
Sbjct: 69 RQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQS 128
Query: 272 RETEAAQMEHQKERNSFEERIQALEEDLREKEREIAT------------EKKNSLKRDKA 319
E + +H K E I+ ++ L+EKE I+T ++S + ++
Sbjct: 129 EEQLS---KHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF 185
Query: 320 IQGLTMALKSKEKKVEELNSEIEKLSAAFAK---AREALQKAQTQ--------------- 361
+ + L+ KE+ + L +++ + A A RE + +TQ
Sbjct: 186 VM-MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQA 244
Query: 362 ----EFQGS--------EDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS 409
E Q E++E +L G+ + L+ + N L + ++++ E +
Sbjct: 245 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304
Query: 410 DL----QQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL----------RNEVNEREK 455
L + ERE + LE+ E ++ + +L+ E+ L + E+ R
Sbjct: 305 TLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYS 364
Query: 456 AMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ-KDVLLQKFNEKDLEVIQQNCYLMAAE 514
A+E ++K+ + E + + ++ + L + + KD + +K+ + +Q + E
Sbjct: 365 ALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE 424
Query: 515 D-LELRSEGL---ITEKCSSQQPPGSKTIFS---KEKKQSSDYEELIQVLKKEQDIYTHL 567
D L+ +S+ + + Q S+T F E Q+ E + + K+ ++
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEK 484
Query: 568 VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESF---- 623
L S + L+AE K+ + LE + + R+ E I +I + S
Sbjct: 485 GALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESG 544
Query: 624 -----SLYSDQTSYLSICLEENN---------RFQVEHFSQEELKKKVSDLIQLVKELYT 669
+ +S + LS+ L E + Q++ EE +V D ++ +
Sbjct: 545 QDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGE 604
Query: 670 DNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKED----EDTIKIGEDDEINFLS 725
+K +F + G FP L E++ L A +++ E + E+ +N
Sbjct: 605 GIAPIKMKVF----LEDTGQDFP--LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAG 658
Query: 726 DQHLQQSNEIMKDLSK----GGCKNGYLRHTESKISDCD----------GAHAPGCLEEG 771
+ + K LS G C L +S+I + + + +E
Sbjct: 659 VELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEI 718
Query: 772 AFINLLAPLFNEKA-------TLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTE 824
+ +N L F + A T L E R LL V+EL + +TE + L+
Sbjct: 719 SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSM----VTELRAQVKQLEMNLA 774
Query: 825 KTPKQKGELVHFVQT---NSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGD 881
+ +Q+ L + QT N ++ L + +++ VK EV + L D +Q + +
Sbjct: 775 EAERQR-RLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI-EVLQNELDDVQLQ-FSEQST 831
Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRL-PI 940
L+R ++ + E + + A H + + ++ +E + +++ +
Sbjct: 832 LIR-SLQSQLQNKESEVLEGAERVRHISSKVEELS---------QALSQKELEITKMDQL 881
Query: 941 LIKPSRSLGNMYR-LPATQEVVTQLQSQILELQGELKEFKTC----NKQLHQKLILAEAV 995
L++ R + + + + + VT++ + E +L E K K L ++L L
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA 941
Query: 996 MEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMD----SDQQRSYEIDS 1051
E + K + V + + + E S E D ++QR ++ +
Sbjct: 942 EEAK----KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQA 997
Query: 1052 EICPPDDLASLPS-CKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETE 1110
+ +L S +E ++ + LS + + + SE TS E
Sbjct: 998 ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
Query: 1111 ---YLKQKIHDLETEL--------------EGYQNFIFQLQKHSQCSEAIITVLCGTEG- 1152
YLKQ I + E EL E +Q + Q+ + Q I +L
Sbjct: 1058 IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISE 1117
Query: 1153 ----AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEE 1208
Q ++ + SDG+ V VK ++ P + E+ K +LEE
Sbjct: 1118 NQAIIQKLITSNTDASDGD--------SVALVKETVVISPPC-----TGSSEHWKPELEE 1164
Query: 1209 QEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICV 1268
+ L+KE+ LQ K ++ R L ++Q +E L R+++K
Sbjct: 1165 KILALEKEK----------EQLQKKLQEALTSRKAILKKAQEKERHL-REELKQ------ 1207
Query: 1269 ISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNT 1328
+ N + + F+E + + E +QL Q L+ + ++GK +
Sbjct: 1208 -QKDDYNRLQEQFDEQSKEN-------ENIGDQLRQ----LQIQVRESIDGKLPSTDQQE 1255
Query: 1329 QNELMERIEED--NLTYQH---------LLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377
+EE T QH L P+ P S + TS ++ ++ +
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQ-LERQGSEFVQGSTS 1436
E + + V+S + + L K+ EE + E++ KQ LE + + V
Sbjct: 1316 AEKVELELKVSSTTSE-----------LTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364
Query: 1437 IFA-------SGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV 1489
+ A S+L + + L+ + L ++ K K+++ L LS K
Sbjct: 1365 VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK----KEEDVSYLSGQLSEKEA 1420
Query: 1490 SLEHLQREYAS----VKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ 1545
+L +Q E +K + +L+ + E + +QL E+ Q+ + EE + +QQ
Sbjct: 1421 ALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQ 1480
Query: 1546 LLSQNDKLLQSLRVELKAYEKLDEE 1570
+ + L S + LK + L EE
Sbjct: 1481 IQRKLQAALISRKEALKENKSLQEE 1505
Score = 78.2 bits (191), Expect = 7e-14
Identities = 138/682 (20%), Positives = 270/682 (39%), Gaps = 114/682 (16%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117
+ +K+ EN +++ ++EN L+ ++ Q + I K NI+ K +++S + +
Sbjct: 2408 KEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME-TLKTIKKENIQQKAQLDSFVKSM 2466
Query: 118 --------------QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKR 163
Q+ E+ + + L + +E ++KE+ R ++DL ++
Sbjct: 2467 SSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRL---------------RLESKLSEMKKMHEG 208
L + ++ + +L + ++++ L +LE KL E ++ +E
Sbjct: 2527 AKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE- 2584
Query: 209 DLAMAL--VLDEKDRL---IEELKLSLKSKEALIQCLKEE------KSQMACPDENV--- 254
DL + + +EK L IE LK+S+ + L+EE +Q+ +E V
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 255 ----SSGELR------GLCAAPRE--------EKERETEAAQMEH-----QKERNSFEER 291
SS + R L +E E + + E + H + E + EER
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704
Query: 292 IQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKA 351
+ L DL E E+++ K + IQ ++ S + + N E+++L + +
Sbjct: 2705 VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS 2764
Query: 352 REALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDL 411
+ L + + Q E AL + A S STE + L ++K+ Q+L
Sbjct: 2765 LKELAQLKEQGLLNRE--RDALLSETAFSM--------NSTEENSLSH-LEKLNQQLLSK 2813
Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKK 471
++ L LE+++ + + L+NE + L NE+ + K+ E + +S S
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2873
Query: 472 LHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDL--------------- 516
Q + K ++ N +D LL++ + +Q N + L
Sbjct: 2874 AEVQ-SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQ 2932
Query: 517 ----ELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI--YTHLVKS 570
ELR E L + Q + E++ Y L+ + K+Q + +L++
Sbjct: 2933 IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY--LMAISDKDQQLSHLQNLIRE 2990
Query: 571 LQESDS-INNLQAELNKIFALRKQLEQD-----VLSYQNLRKTLEEQISEIRRREEESFS 624
L+ S S L+ + + + D V + LR L + + EI ++E
Sbjct: 2991 LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQ 3050
Query: 625 LYSDQTSYLSICLEENNRFQVE 646
L S+ S LEE N ++
Sbjct: 3051 LNSN----FSQLLEEKNTLSIQ 3068
Score = 72.8 bits (177), Expect = 3e-12
Identities = 133/669 (19%), Positives = 279/669 (41%), Gaps = 141/669 (21%)
Query: 64 ENQITELK-KENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQ 122
+ Q+ E++ ++N L+ + LEE+++ E E + ++ L+ E + L +E++ +
Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEKLK-ESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Query: 123 LLIKASKAVESLAEAGGSEIQ----RVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAEL 178
+ + ++ V +L E G + +VKE+ ++ + KRI LE+++ Q E
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 179 EKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLIEELKLSL-KSKEAL 236
K +E KL E+K +H M + + + EL L + ++ L
Sbjct: 2670 AKKVG----------EIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719
Query: 237 IQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALE 296
+ KE K A + S G R+ E + + ++ S +E Q E
Sbjct: 2720 LMVTKENKGLTA---QIQSFGRSMSSLQNSRDHANEELDELKRKYDA---SLKELAQLKE 2773
Query: 297 EDLREKERE---------IATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE---KL 344
+ L +ER+ + + ++NSL ++ L L SK++++ L+S++E
Sbjct: 2774 QGLLNRERDALLSETAFSMNSTEENSLSH---LEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRS-----QNLTKSTENHRLRR 399
+F+KA +LQ + + E + + GK+ +A + Q+L K+ + L+
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS--LQN 2888
Query: 400 SIKKITQELSDLQQERERLEKDLEEAH---------REKSKGDCTIRD--------LRNE 442
++ +EL +LQQ+ ++ +++ E H ++K+K +++ ++E
Sbjct: 2889 DRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHE 2948
Query: 443 VEKLRNEVNE---REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499
+ +LR E + E+ M+ +Y +S+ +++L + + +I+ L S++Q L ++
Sbjct: 2949 LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR- 3007
Query: 500 DLEVIQQNCYLMAAEDLELRSEGLI--TEKCSSQQPPGSKTIFSKE---KKQSSDYEELI 554
Q + A+ D S+ L+ TE +Q K I KE ++ +S++ +L+
Sbjct: 3008 -----QASPETSASPD---GSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLL 3059
Query: 555 --------------QVLKKEQDIYTHLV-------KSLQE-------------------- 573
Q L++ Q Y L+ K +QE
Sbjct: 3060 EEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNG 3119
Query: 574 --------------------SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQIS 613
+ N + E+N++ L ++ ++ +N EEQI
Sbjct: 3120 VHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR 3179
Query: 614 EIRRREEES 622
+ E +S
Sbjct: 3180 RLEHSEWDS 3188
Score = 55.8 bits (133), Expect = 4e-07
Identities = 115/508 (22%), Positives = 206/508 (40%), Gaps = 102/508 (20%)
Query: 48 SEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK 107
+EE V+ AR++ + E ++ + KEN L +I M +H + ELK
Sbjct: 2701 AEERVAEL-ARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS-LQNSRDHANEELDELK 2758
Query: 108 VEVESLKREL----------QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVE 157
+ ++ +EL +ER+ LL + + ++ S E S ++++ + K +Q+
Sbjct: 2759 RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818
Query: 158 DLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLD 217
L ++ LE Q+ KA A + E R L ++L + +K EG A
Sbjct: 2819 HLSSQ----LEDSYNQVQS-FSKAMASLQNE---RDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 218 EKDRLIEELKLSLKS----KEALIQCLKEEKSQMACPDENVSSGELRGLCAAPRE--EKE 271
++ LK ++ S ++ L++ LK + Q ++ ++ EL L A +E +K
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT--ELHPLKAQLQEYQDKT 2928
Query: 272 RETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKE 331
+ + Q E ++E S++ + L + E K+ L MA+ K+
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL----------MAISDKD 2978
Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQ---EFQGSED------YETAL-------SG 375
+++ L + I +L ++ ++ + + Q Q E S D YET L S
Sbjct: 2979 QQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSL 3038
Query: 376 KEALSAALRSQNLT---------KSTENHRL---RRSIKKITQELSDLQQERERLEKDLE 423
KE LR Q L K+T + +L +S+++ Q DL LEK ++
Sbjct: 3039 KEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQ 3098
Query: 424 E-------------AHREKS----KGD------------------CTIRDLRNEVEKLRN 448
E A +EK+ K D C R NE+ KL
Sbjct: 3099 ELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLE 3158
Query: 449 EVNEREKAMENRYKSLLSESNKKLHNQE 476
E ++ A EN S+ E ++L + E
Sbjct: 3159 EERDQRVAAENAL-SVAEEQIRRLEHSE 3185
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 116 bits (291), Expect = 2e-25
Identities = 167/777 (21%), Positives = 313/777 (40%), Gaps = 129/777 (16%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIE-LKVEVESLKRE 116
R ++D E +I LK N L EE M+Q +Y+++ + +K +VE LK E
Sbjct: 396 RGLRDLEEEIQMLKS---NGALSTEEREEEMKQM------EVYRSHSKFMKNKVEQLKEE 446
Query: 117 LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-------------R 163
L +E + K L +EI +VK++ +K ++ L TK
Sbjct: 447 LSSKEAQWEELKKKAAGLQ----AEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH 502
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESK-------------LSEMKKMHEGDL 210
I +L++ +TA E A TE + ALRLRLE K ++E K G++
Sbjct: 503 IEVLKESLTAK--EQRAAILQTEVD-ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Query: 211 A-MALVLDEKDRL-------IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSG----- 257
+ +LD K+R IE L+ L+ KE + LKE + N +
Sbjct: 560 HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619
Query: 258 ----ELRGLCAAPREEKERETEAAQME---HQKERNSFEERIQALEEDLREKEREIATEK 310
E +E+++R+ Q E ++K+ +E++ L+ DL EKE + K
Sbjct: 620 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
Query: 311 KNS-------LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEF 363
+++ LK+D ++ L +AL+ K+++ ++ S+++K
Sbjct: 680 EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA------------------- 720
Query: 364 QGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLE 423
+E AL + + + R Q+L R I + E S Q E +RL + L+
Sbjct: 721 -----HEAALEARASPEMSDRIQHL---------EREITRYKDESSKAQAEVDRLLEILK 766
Query: 424 EAHREKSKGDCTIRDLRNEVEKLRNEV---NEREKAMENRYKSLLSESNKKLHNQEQVIK 480
E EK+ D I +L +V+ +V +E+ + + +L E+ ++ N +
Sbjct: 767 EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQ 826
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQ----QNCYLMAAEDLELRSEGLITEKCSSQQPPGS 536
L +S +KD +++ E E +Q + L E +E + E + +
Sbjct: 827 QLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV-K 885
Query: 537 KTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQ 596
+ + S + K SS + L + KE + + + + + ++ E K
Sbjct: 886 QELESMKAKLSSTQQSLAE---KETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
Query: 597 DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN---NRFQVEHFSQEEL 653
+L + +K +E+++ ++R ++ QT + +N + F+ H +Q
Sbjct: 943 ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002
Query: 654 KKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTI 713
K +IQ + EL + LK I L+ L +L +
Sbjct: 1003 KPSPDQIIQPLLELDQNRSKLKLYIGHLTT-----------LCHDRDPLILRGLTPPASY 1051
Query: 714 KIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEE 770
+ +DD+ + ++ ++ +L KG N L+ + I H P LE+
Sbjct: 1052 NL-DDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQ 1107
Score = 67.8 bits (164), Expect = 1e-10
Identities = 189/923 (20%), Positives = 365/923 (39%), Gaps = 152/923 (16%)
Query: 40 GNGLLPNVSEETVSP-----TRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHG 94
G LP VS + P R + D + Q+ E+ +EN L+ + E ++ +
Sbjct: 126 GEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNS 185
Query: 95 PTEHIYKT--NIELKVEVESLKREL------QEREQLLIKASKAVESLAEAGGSEIQRVK 146
KT + ELK E K E +E+ +++ + ++ ++ +A E+ R++
Sbjct: 186 -----IKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-RIQ 239
Query: 147 EDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH 206
D + QQ T + E + ++ A E + L L EM+
Sbjct: 240 RDLNQLFQQDSSSRTGEPCVAE----LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI 295
Query: 207 EGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMA-CPDENVSSGELRGLCAA 265
E L+ +D I++L L+SK + +E+ + + + L L
Sbjct: 296 E---TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL-- 350
Query: 266 PREEKERETEAAQME-HQKERNS---------------FEERIQALEEDLREKEREI--- 306
E+KE+E + E H++ N+ + +I ++E LR+ E EI
Sbjct: 351 --EQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML 408
Query: 307 -------ATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQ 359
E++ +K+ + + + +K+K ++++ E+LS+ A+ E +KA
Sbjct: 409 KSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK------EELSSKEAQWEELKKKA- 461
Query: 360 TQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLE 419
+G +A ++ + K TE L+ ++ +T + SD +Q E L+
Sbjct: 462 --------------AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK 507
Query: 420 KDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQV- 478
+ L + + L+ EV+ LR + E+E + + K + + +K ++
Sbjct: 508 ESLTAKEQRAA-------ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
Query: 479 -IKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSK 537
+K + + +K +LQK E E ++ M++ ++S T + +
Sbjct: 561 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620
Query: 538 TIFSKEK-----KQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRK 592
+ KE+ K+ D +E + ++E D Y +K L+E S+ LQ +L++ A
Sbjct: 621 ALAEKERTIERLKEQRDRDE--REKQEEIDNYKKDLKDLKEKVSL--LQGDLSEKEASLL 676
Query: 593 QLEQDV--LSYQNLRKTLEEQISEI--RRREEESFSLYSDQTSYLSICLE----ENNRFQ 644
L++ L+ L+K + EI +++EE + S LE +
Sbjct: 677 DLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
Query: 645 VEHFSQE---------ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL 695
++H +E + + +V L++++KE+ + K I +L N L
Sbjct: 737 IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL 796
Query: 696 ASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESK 755
EQ E S + + + ED+ + S Q LQ S LR + +
Sbjct: 797 KHKEQVEKKKSAQMLEEARRREDNLND--SSQQLQDS----------------LRKKDDR 838
Query: 756 ISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLE---SRPDLLKVVRELLLGQLFLTEQ 812
I + + A L E I E+ +L + +R + K V ELL+ + +Q
Sbjct: 839 IEELEEA-----LRESVQITA------EREMVLAQEESARTNAEKQVEELLMA-MEKVKQ 886
Query: 813 EVSGEHLDGKTEKTPKQKGEL-VHFVQTNSFSKPHDE--LKLSCEAQLVKAGEV-PKVGL 868
E+ E + K T + E H + + H E L++ EA L E + L
Sbjct: 887 EL--ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
Query: 869 KDASVQTVATEGDLLRFKHEATR 891
+ S T+ ++ K E R
Sbjct: 945 LELSSSKKKTQEEVAALKREKDR 967
Score = 47.8 bits (112), Expect = 1e-04
Identities = 68/281 (24%), Positives = 115/281 (40%), Gaps = 56/281 (19%)
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
M ++ L I L+ +L+E ++ N+ LRK +E + S+ SI
Sbjct: 135 MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI----KTFW 190
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
S + LRK + + + R Q+EN ++ ++++ LQ E ++ N
Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-------MTIQALQDELRIQRDLN 243
Query: 1506 ERLQKEGSEK----------ERHNQQLIQEVRCSGQEL---SRVQEEVKLR----QQLLS 1548
+ Q++ S + E + Q+L E +EL + EE++LR +Q L+
Sbjct: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
Query: 1549 QNDK-------LLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQAL 1601
D+ +LQS + KA E+ E RRL EA M +
Sbjct: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAE-----------------MHVH-- 344
Query: 1602 RLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAV 1642
LE +E S L+E++ R E A + A T A+Q V
Sbjct: 345 --HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTV 383
Score = 41.6 bits (96), Expect = 0.007
Identities = 103/578 (17%), Positives = 231/578 (39%), Gaps = 89/578 (15%)
Query: 1099 QSESINTSNE---TEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQD 1155
Q +S + + E E ++ L E E +F L+K + E I T A+D
Sbjct: 247 QQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARD 306
Query: 1156 -------------GLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENL 1202
GLS D E T +V H++ L E +S + E +
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEED-HERTRRLAEAEMHVHHLESLLE-QKEKENSMLREEM 364
Query: 1203 KQQLEE--QEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPP----RYDSLVQSQARELSLQ 1256
++ E K + Q + S+I +++ RDL + + + ++ RE ++
Sbjct: 365 HRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK 424
Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDY----CVAEGFQEQLNQCAELLEKL 1312
+ ++ H + M ++ +E L + + + A G Q ++ Q + L +
Sbjct: 425 QMEVYRSHS------KFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK 478
Query: 1313 EKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSR 1372
+ L + T+ E + D+ + +L ES A + +T + R
Sbjct: 479 DTELL-------ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRA-AILQTEVDALRLR 530
Query: 1373 DQKQDNETEKTSVMVNSFSQ-------------DLLMEHIQEIRTLRKRLEESIKTNEKL 1419
++++ K + + ++ D+L +++ L+K++E E+L
Sbjct: 531 LEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN---LQEQL 587
Query: 1420 RKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDK 1479
R + E+Q S + S+ A + ++LT+ L ++ + + + + RD++++ ++
Sbjct: 588 RDK-EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 646
Query: 1480 LRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERH------------NQQLIQEVR 1527
+ ++ +++ +KE+ LQ + SEKE + L ++ R
Sbjct: 647 I-----------DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSR 695
Query: 1528 CSGQELS---RVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKG 1584
E++ + +E +K+ QL ++ L++ R + +++ R + E K
Sbjct: 696 LKTLEIALEQKKEECLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKA 754
Query: 1585 QDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQ 1622
Q L +L E++ + ++ I + L+ ++K+Q
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKI---AELERQVKDQ 789
Score = 41.2 bits (95), Expect = 0.010
Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 45/397 (11%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
+ENL++QL ++E ++ + L ++ N L ++L + + L+ Q
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE----EALAEKERTIERLKEQ 635
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
+ +D R+ + ++L + + E+ +L E L +
Sbjct: 636 RDRD-------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 688
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD-QKQD 1377
G + T +E+ +E+ L + L ++ E + S + R+ +
Sbjct: 689 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 748
Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRK-------RLEESIK------TNEKLRKQLE 1424
+E+ K V D L+E ++E+ + LE +K N K ++Q+E
Sbjct: 749 DESSKAQAEV-----DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 803
Query: 1425 RQGS-----EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN-AMLIKGSRDKQKEND 1478
++ S E + ++ S +L SL + + + +AL ++ I R+ +
Sbjct: 804 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 863
Query: 1479 KLRESLSRKTV-----SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
+ + + K V ++E +++E S+K + Q+ +EKE H L E R +E+
Sbjct: 864 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+++E L +S+ D + L EL + +K +E
Sbjct: 924 LEMKQEALL--AAISEKDANIALL--ELSSSKKKTQE 956
Score = 38.5 bits (88), Expect = 0.063
Identities = 77/448 (17%), Positives = 183/448 (40%), Gaps = 33/448 (7%)
Query: 1096 GTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKH-SQCSEAIITVLCGTEGAQ 1154
GT E + + + ++K++ L+ ++E Q + +K S E + ++ T
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDS--RVLENLKQQLEEQEYK 1212
L+ + +E T L + R + E ID+ + L++LK+++ +
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDERE-----KQEEIDNYKKDLKDLKEKVSLLQGD 667
Query: 1213 LQKEQNLNMQLFSEIHNLQNKF--RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
L +++ + L +L + +D + ++ + E Q+K H + +
Sbjct: 668 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 727
Query: 1271 RQ--HMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGV--- 1324
R M+ I+ E E+ + D + Q ++++ E+L+++E N K +
Sbjct: 728 RASPEMSDRIQHLEREITRYKDE----SSKAQAEVDRLLEILKEVENE-KNDKDKKIAEL 782
Query: 1325 --EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---- 1378
++ QN+ + ++ + + E + + ++S++ S +K D
Sbjct: 783 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 842
Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437
E + SV + + + +L + K++EE + EK++++LE ++ S+
Sbjct: 843 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497
+ L + L + + L+ +K L S S+K Q E
Sbjct: 903 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT-----QEE 957
Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQE 1525
A++K E +RL ++ ++ ++ +L+ +
Sbjct: 958 VAALKREKDRLVQQLKQQTQNRMKLMAD 985
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 116 bits (290), Expect = 2e-25
Identities = 195/896 (21%), Positives = 365/896 (40%), Gaps = 180/896 (20%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + TRAR+ K + EL+KEN LK +++ +E + E + + N+ L++
Sbjct: 364 EDQLEGTRARSDK-----LHELEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEM 417
Query: 109 -EVESLKRELQ---EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
+ +S+ L E EQ+ + S+ E+ ++ G E+ + K++ LTK +
Sbjct: 418 AQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLE----SKLSEMKKMHEGDLAMALVLDEKD 220
L V + + K + + L ++E + E + + ++ EK
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 221 RLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE----- 275
+L + ++ ++ E I+ L++E + ++ VSS R +A K+ E E
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 276 --------------------AAQMEHQKERNSFEERIQALEEDLR--EKEREI------- 306
++EH KE+ ER + LE +L EKE E+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEELENELHHLEKENELLQKKITN 650
Query: 307 ---------ATEKKNS-LKRDK--------AIQGLTMALKSKEKKVEELNSE-------I 341
A E++NS L+R+ + + LT L+S EK+ +L+ E +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 342 EKLSAAFAKAREA------LQKAQTQEFQGSEDYETALSGKEALSAA-----LRSQNLTK 390
E L A K + L+ + Q +G E + + E L + + +Q L K
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
+ EN + I+++ EL DL+ E + L+K+LEE + + L E + L E
Sbjct: 771 TLENSN--KKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQET 824
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE---KDLEVIQQN 507
++ EK K L + NK+L Q ++ E N K L+K N+ K++ + +++
Sbjct: 825 SQLEKD-----KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 508 CYLMAAEDLELRS----------------EGLITEKCSSQQPPGSKTIFSKE-KKQSSDY 550
C + + E + E L++EK +QQ + E +K +
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---KT 607
E L+ + D L++S ES +L+ + KI AL +LE+ Q LR KT
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQL---- 663
+++ +++R++E + S I E+N + + EL K LI++
Sbjct: 1000 VKKNYEALKQRQDEERMVQSSP----PISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 664 -------------VKELYTDNQHLKKTIFDL--SCMGFQGNG-----------FPDRLAS 697
+K+L T N +L+ I L + Q + +
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 698 TEQTELL----------ASKEDEDTIKIGEDDEINFLSDQ-----------HLQQSNEIM 736
++ T L+ +S E+E+ I E +++ L D H +Q++E
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 737 KDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792
+SK G ++ E + D + + ++G +L L E+ +LLE++
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1231
Score = 110 bits (274), Expect = 2e-23
Identities = 320/1466 (21%), Positives = 569/1466 (38%), Gaps = 268/1466 (18%)
Query: 40 GNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHI 99
G LP+ S SP + MK E++ L E + K +I R++QE TE +
Sbjct: 220 GLHFLPHASSSAQSPCGSPGMKRTESR-QHLSVELADAKAKI----RRLRQELEEKTEQL 274
Query: 100 YKTNIELKVEVESLKRELQEREQLLIKASKA------VESLAEAG------GSEIQRVKE 147
EL+ LKR QE LL A A +++L E SE+ R KE
Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE 334
Query: 148 ---DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK- 203
D +VE+L +LLE + LE GT LE + ++K
Sbjct: 335 RLHDIEFYKARVEELKEDNQVLLE-----TKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 204 KMHEGDLAMALVLDEKDRLIEE-LKLSLKSKEALIQCLK--EEKSQMACPDENVSSGELR 260
K+H+ ++ + + + L+EE + L + K+++ + L E Q++ E +S +
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-LSEAPQK 448
Query: 261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNS--LKRDK 318
L E +ME+Q + EE ++ + + EK+N K+ +
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 319 AIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ-------KAQTQEFQGSEDYET 371
++ + K + + L+ ++ K A K E L+ K QE + +
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSK 431
+L + +SA R +++ K EN L SIK+ + +LS ++ E+ +++K+LE K K
Sbjct: 569 SLRQRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELE---HYKEK 623
Query: 432 GDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--LSESNKKLHNQEQVIKHLTESTNQK 489
G+ E+L NE++ EK E K + L + +K+ EQ L +
Sbjct: 624 GE--------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 490 DVLLQKFNEK--DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
L F LE +++ + E+LELR + + KC+S + ++ + ++
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELR-RNVESLKCASMK-------MAQLQLEN 727
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT 607
+ E + LKK ++ L+A K L + + Q L+KT
Sbjct: 728 KELESEKEQLKKGLEL----------------LKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
LE +I++ E E L + + L LEE ++ E+L+K+ L Q +L
Sbjct: 772 LENSNKKIQQLESELQDLEMENQT-LQKNLEE---LKISSKRLEQLEKENKSLEQETSQL 827
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
D + L+K + +Q E+ + +E+ +KIG
Sbjct: 828 EKDKKQLEK----------------ENKRLRQQAEIKDTTLEENNVKIG----------- 860
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787
+L++ N K LSK G + C+ L L E L
Sbjct: 861 NLEKEN---KTLSKE-----------------IGIYKESCVR-------LKELEKENKEL 893
Query: 788 LLESRPDL--LKVVRELLLGQLFLTEQEVSG-EHLDGKTEKTPKQKGELVHFVQTNSFSK 844
+ + D+ L +RE L+ + T+Q + E L + EK K L+H Q+ S+
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 845 PHDELKLSCEAQLVKAGEV--PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTA 902
+ L+ E+ L K+ E+ K+ +A ++ LR + + ++ +E A
Sbjct: 954 -YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE------A 1006
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSR-----LPILIKPSRSLGNMYRLPAT 957
L E + + S P I+ + K R L+K L + R AT
Sbjct: 1007 LKQRQDEERM---------VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQPPVGA 1015
LQ++ L+ +LK+ +T N L +++ + + TL NA+ V
Sbjct: 1058 ------LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE--ICPPDDLASLPSCKENPEDVL 1073
+ +S ++S+ QQ S E ++E I +DL SL + L
Sbjct: 1112 STLNS--------QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE--------TEYLKQK--IHDLETEL 1123
+ S+ + +S GT +S N E + LKQK + DLE L
Sbjct: 1164 E----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1219
Query: 1124 EGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSL---HQVRYV 1180
+ Q + K+ + A LCG +D T+S L +V
Sbjct: 1220 KVEQEKMLLENKNHETVAAEYKKLCGE-------------NDRLNHTYSQLLKETEVLQT 1266
Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL---QKEQNLNMQLFSEIH-NLQNKFRD 1236
H + L ++ LE +L+EQ +L + N +L S++ NL+ + R
Sbjct: 1267 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1326
Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAE 1296
L Q + L LQ + + E+ +++ D+ +
Sbjct: 1327 L---------LDQIQTLMLQNRTL--------------------LEQNMESKDLFHVEQR 1357
Query: 1297 GFQEQLNQCAELLEKLEKLFLN-------------GKSVGVEMNTQNELMERIEEDNLTY 1343
+ ++LN+ EKLE+ ++ G + ++M +L++ ++ N
Sbjct: 1358 QYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM---RKLIKSKKDINRER 1414
Query: 1344 QHLLPESPEPSASH----ALSDYETSEKSFFSRDQKQDNET--EKTSVMVNSFSQDLLME 1397
Q L +P S S L ++ + S + +D +T K S +N Q +++
Sbjct: 1415 QKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLA 1474
Query: 1398 HIQEIRTLRKRLEESIKTNEKLRKQL 1423
T + + I T K RK+L
Sbjct: 1475 GQWTGSTENLEVPDDISTG-KRRKEL 1499
Score = 72.8 bits (177), Expect = 3e-12
Identities = 107/535 (20%), Positives = 227/535 (42%), Gaps = 56/535 (10%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL-VQSQARELSLQR 1257
L + KQ+LE+ E +L++ Q NM L S+ + + +L R ++ V E+S +
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333
Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFL 1317
+++ D + + + + + LL+ + EG + + ++ EL ++ +L
Sbjct: 334 ERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 1318 NGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377
+ +E + + +E + E+N+T + +S + S + S S S ++
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
Query: 1378 -----NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-------KTNEKLRKQLER 1425
NE + ++ L + ++E+RT +E + K N++L K++E
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
+E VQ S+ + L L E L K + L + + ++EN+ L +++S
Sbjct: 510 LENEIVQEKQSL-QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 1486 ----RKTVSLE----HLQRE----YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
R +S E +++E + S+KE + +L K EK + ++L + + G+
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRD--- 1590
++ E+ ++ K + +L++ + E L++E+ L + + K D F++
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 1591 -LHSLLMEIQAL---RLQLERSIETSSTLQSRL-------------KEQLARGAEKAQEG 1633
L SL E L L+L R++E+ ++ KEQL +G E +
Sbjct: 688 QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Query: 1634 -----ALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSE 1683
L ++ Q + I LQ + +K + ++ + K++ E
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Score = 72.4 bits (176), Expect = 4e-12
Identities = 151/817 (18%), Positives = 311/817 (38%), Gaps = 98/817 (11%)
Query: 1067 ENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126
EN + + T + S ++K+ M + E+ S + E L+ +I + L+
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKM---EKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 1127 QNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL 1186
QN L K E I L Q + + +N + T SSL Q +
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQIS----- 577
Query: 1187 GPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
A + EN L + ++E KL K + Q+ E+ + + K
Sbjct: 578 ---AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----------- 623
Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304
+A EL + ++ + + Q T +K E ++A +++ ++
Sbjct: 624 --GERAEELENELHHLEKENELL----QKKITNLKITCEKIEA----------LEQENSE 667
Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364
KL+K + K++ ++ + + +++E+NL + + S A E
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424
E K+ E K S + L Q + +RL+++++ + K +QLE
Sbjct: 728 KELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN---AMLIKGSRDKQKENDKLR 1481
+ + + ++ + EL S + + L K+N++L + L K + +KEN +LR
Sbjct: 784 SELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+ K +LE + ++++EN+ L K E+ +E
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSK---------------------EIGIYKESCV 881
Query: 1542 LRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQAL 1601
++L +N +L++ +++K L E + E K Q DL L E++ +
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLRE------DLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 1602 RLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPM 1661
L ER + + + L E + +L + + ++ E L+ + +
Sbjct: 936 GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 995
Query: 1662 ESDNSFDLFDS--SQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLW 1719
E +++ + + V +PP+SG D + S T+ + V +
Sbjct: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDN---KWERESQETTRELLK--VKDRLIE 1050
Query: 1720 ASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKF 1779
+N + + + LKQ+ L + Q S ++ T A L
Sbjct: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1110
Query: 1780 VSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1839
S++++ +L +L L+ + SL + E + + + ++ L+ L + +K
Sbjct: 1111 NSTLNSQSTSLMNQNAQL-LIQQSSLENEN------ESVIKEREDLKSLYDSLIKDHEK- 1162
Query: 1840 QNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLEL 1876
L+L ++ ++ L+ H L+ A NLE+
Sbjct: 1163 ------LELLHERQASEYESLISKHGTLKSAHKNLEV 1193
Score = 66.2 bits (160), Expect = 3e-10
Identities = 260/1409 (18%), Positives = 533/1409 (37%), Gaps = 241/1409 (17%)
Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201
++++K ++ +QQ+ + +L++ K+ + Q GTE K L L L
Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQ--------GTEEVKKLLLLL------ 128
Query: 202 MKKMHEGDLAMALVLDEKDRLIEELK-LSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
L A+ +K+ IE ++ L +K A+ ++E ENV +
Sbjct: 129 --------LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQ----ENVFDLQWM 176
Query: 261 GLCAAPREEKERETEAAQMEHQK---ERNSFEERIQALEEDLREKEREIATEKKNS---- 313
+ +E+ E + + ++ ER+ E I L E+ R+ + ++
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEE-RDGLHFLPHASSSAQSPC 235
Query: 314 ----LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369
+KR ++ Q L++ L + K+ L E+E+ + ++ L++ + + + ++
Sbjct: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 370 ETALSGKEALSAALRSQNL----TKSTENHRLRRSIKKITQELSDLQQERERLEK----- 420
LS +A SA + L K+ +L + + + L D++ + R+E+
Sbjct: 296 MNLLS--DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 421 ----------------------DLEEAHREKSKGDCTIRDL-------RNEVEKLRNE-- 449
L E +E + + D+ R ++E+L E
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 450 ----------------------VNEREKAMENRYKSLLSESNK-------KLHNQEQVIK 480
++ + E KSL E N+ KL + Q +
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
E ++ K L++ ++N L ++ +E+ ++ EK S Q
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 541 SKEKKQ--------SSDYEELIQVLKKEQDIYTHLVKSLQE------------------- 573
KEK Q + E I++L++E + V SL++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 574 -SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632
+SI ++L+KI ++Q+++++ Y+ + EE +E+ E+E+ L T+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
C +K+ L Q EL +N+ LKKT+ + FQ
Sbjct: 652 KITC------------------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 693 DRLASTEQTELLASKEDEDTIKIGEDDEINF-LSDQHLQQSNEIMK---DLSKGGCKNGY 748
+ ++ E L + + +++K L ++ L+ E +K +L K K
Sbjct: 694 KENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 749 LRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLF 808
+ D + LE + L +E L +E++ L K + EL +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSN--KKIQQLESELQDLEMENQ-TLQKNLEELKISSKR 809
Query: 809 LTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVKAGEVPKVG 867
L + E + L+ +T + K K +L + N + E+K + E VK G + K
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 868 LKDASVQTVATEGDLLRFK--HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSL 925
K S + + +R K + +E + I+ R + + Q L
Sbjct: 867 -KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 926 PGITNREAK----KSRLPILIKPSRSLGNMYRLPATQEVVTQLQS------QILELQGEL 975
+T+ K K RL L + + Y+L ++ T +S +I L+ L
Sbjct: 926 EKLTHELEKIGLNKERL--LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 976 KEFKTCNKQLHQKLILAEAVMEG--RPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSV 1033
+E N+QL Q+L + E + ++ ++ + PP+ +D+ E++ +TT +
Sbjct: 984 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--EDNKWERESQETTREL 1041
Query: 1034 WRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA-TYLSSKSQPSAKV 1092
+ K+ + +R+ A+L + K+ + L L ++ +
Sbjct: 1042 LKVKDRLIEVERNN------------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHS--QCSEAIITVLCGT 1150
+V +Q+ ++ T N ++ + ++ QN +Q+ S +E++I
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 1151 EGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQE 1210
+ D L K + +S ++ KH + ++ R LE+ QL +Q+
Sbjct: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209
Query: 1211 YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
+L+ + + +++ E L+NK + Y L R Q +K+ V+
Sbjct: 1210 GQLEDLEKM-LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE---VLQ 1265
Query: 1271 RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330
H N + LL S ++ E + ++L E+ ++L + + + +
Sbjct: 1266 TDHKN-----LKSLLNNSKLEQTRLEA------EFSKLKEQYQQLDITSTKLNNQCELLS 1314
Query: 1331 ELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389
+L +EE+N +HLL + + L + K F +Q+Q
Sbjct: 1315 QLKGNLEEEN---RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ------------- 1358
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEK 1418
++ + E+R +++LEE I K
Sbjct: 1359 -----YIDKLNELRRQKEKLEEKIMDQYK 1382
Score = 62.8 bits (151), Expect = 3e-09
Identities = 261/1412 (18%), Positives = 542/1412 (38%), Gaps = 234/1412 (16%)
Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
+++ F ERIQ L+ D + E ++ + +Q + + S+E +IE
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--------DIE 187
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
L A + L + + + + G L A S + + S +
Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
++ EL+D + + RL ++LEE + + D + E+E++ E+ K ++
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIEL----KRLQQENM 296
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+LLS++ ++++ D L +K D + + Y D+E
Sbjct: 297 NLLSDARSARMYRDEL-----------DALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
+ K +Q +KT+ + + + + + L+KE +LQ +++++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---------NLQLKAKLHDMEM 396
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
E + RK++E+ L E+ + +++S D++ +L LE+ +R
Sbjct: 397 ERDMD---RKKIEE-----------LMEENMTLEMAQKQSM----DESLHLGWELEQISR 438
Query: 643 F-QVEHFSQEELKKKVSDLIQL-VKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
++ Q+ L +V++L + +L +NQ L KT+ +L G ++ E+
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760
SK+ ++I E++ + Q LQ + KDL K + L T + +
Sbjct: 499 ENQRLSKK----VEILENEIVQ--EKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENS 549
Query: 761 GAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820
+E +N +++ + E+R ++ ++L + T ++S
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS----- 604
Query: 821 GKTEKTPKQ-KGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATE 879
K E +Q K EL H+ K+ + E
Sbjct: 605 -KIEFEKRQIKKELEHY--------------------------------KEKGERAEELE 631
Query: 880 GDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLP 939
+L + E E ++K N ++ E AL RE +K
Sbjct: 632 NELHHLEKE--NELLQKKITNLKITCEKIE-----------ALEQENSELERENRK---- 674
Query: 940 ILIKPSRSLGNM-YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEG 998
L K S N+ ++L + ++ +QL + LEL+ ++ K + ++ Q L L +E
Sbjct: 675 -LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELES 732
Query: 999 RPTPDKT---LLNAQ----PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDS 1051
K LL A + +YQ E + ++ T +++ ++ +++S
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT--------LENSNKKIQQLES 784
Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY 1111
E+ DL + + L +S K S + ++ + E +
Sbjct: 785 EL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKR 840
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF 1171
L+Q+ +T LE I L+K ++ I + + L K + +E+
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-----ENKELV- 894
Query: 1172 SSLHQVRYVKHVKILGPLAPEMIDSRV-LENLKQQLEEQEYKLQK-EQNLNMQLFSEIHN 1229
R +K L L +++ ++ + + LE+ ++L+K N L E
Sbjct: 895 -----KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 1230 LQNKFRDLSPPRYDSLVQS---QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
++++ L +L +S + +++ ++++ RQ + T+ K +E L Q
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009
Query: 1287 ASDVDYCVAEG-------------FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM 1333
D + V QE + ++ ++L ++ N ++ E +
Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
Query: 1334 ERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQD 1393
+++E N Q + + S L + T+ ++ ++ Q +++ S + + +
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127
Query: 1394 LLMEH----------IQEIRTLRKRLEESIKTNEKLRKQLERQGSEF---VQGSTSIFAS 1440
LL++ I+E L+ + IK +EKL ERQ SE+ + ++ ++
Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1187
Query: 1441 GSEL---HSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESLSRKTVSL---- 1491
L H L + L KQ L + ++K ++K +K E+++ + L
Sbjct: 1188 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1247
Query: 1492 EHLQREYASVKEENERLQKEGSE-KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN 1550
+ L Y+ + +E E LQ + K N +++ R E S+++E+ QQL +
Sbjct: 1248 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-EFSKLKEQY---QQLDITS 1303
Query: 1551 DKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQ----LE 1606
KL + + L+EE+R LL +IQ L LQ LE
Sbjct: 1304 TKLNNQCELLSQLKGNLEEENRH--------------------LLDQIQTLMLQNRTLLE 1343
Query: 1607 RSIETSSTLQSRLKE------QLARGAEKAQE 1632
+++E+ ++ +L R EK +E
Sbjct: 1344 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
Score = 32.3 bits (72), Expect = 4.5
Identities = 72/333 (21%), Positives = 132/333 (39%), Gaps = 47/333 (14%)
Query: 1310 EKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF 1369
E+++KL L V+ + E +ERI Q L ++ A+H E F
Sbjct: 119 EEVKKLLLLLLGCAVQCQKKEEFIERI-------QGLDFDTKAAVAAHIQEVTHNQENVF 171
Query: 1370 FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSE 1429
D + + + M + LL ++ L +E +T +L + ER G
Sbjct: 172 -------DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE--ERDGLH 222
Query: 1430 FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV 1489
F+ ++S S +E Q L+ L D + + +LR+ L KT
Sbjct: 223 FLPHASSSAQSPCGSPGMKRTE------SRQHLSVELA----DAKAKIRRLRQELEEKTE 272
Query: 1490 SLEHLQREYASVKEENERLQKEG------SEKERHNQQLIQEVRCSGQELSRVQEEVKLR 1543
L ++E ++ E +RLQ+E + R + + +R + +++ EV
Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
Query: 1544 QQLLSQNDKLLQSLRV-ELKAYEKLDEEHRRLREASGEGWKGQ-DPFRD----------- 1590
++ L +D RV ELK ++ E + + E EG + + D +
Sbjct: 333 KERL--HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 1591 LHSLLMEIQALRLQLERSIETSSTLQSRLKEQL 1623
LH + ME R ++E +E + TL+ K+ +
Sbjct: 391 LHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 115 bits (288), Expect = 4e-25
Identities = 196/896 (21%), Positives = 366/896 (40%), Gaps = 181/896 (20%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + TRAR+ K + EL+KEN LK +++ +E + E + + N+ L++
Sbjct: 364 EDQLEGTRARSDK-----LHELEKENLQLKAKLHDMEMERDMD-RKKIEELMEENMTLEM 417
Query: 109 -EVESLKRELQ---EREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
+ +S+ L E EQ+ + S+ E+ ++ G E+ + K++ LTK +
Sbjct: 418 AQKQSMDESLHLGWELEQIS-RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLE----SKLSEMKKMHEGDLAMALVLDEKD 220
L V + + K + + L ++E + E + + ++ EK
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 221 RLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE----- 275
+L + ++ ++ E I+ L++E + ++ VSS R +A K+ E E
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHL---NQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 276 --------------------AAQMEHQKERNSFEERIQALEEDLR--EKEREI------- 306
++EH KE+ ER + LE +L EKE E+
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEELENELHHLEKENELLQKKITN 650
Query: 307 ---------ATEKKNS-LKRDK--------AIQGLTMALKSKEKKVEELNSE-------I 341
A E++NS L+R+ + + LT L+S EK+ +L+ E +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 342 EKLSAAFAKAREA------LQKAQTQEFQGSEDYETALSGKEALSAA-----LRSQNLTK 390
E L A K + L+ + Q +G E + + E L + + +Q L K
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
+ EN + I+++ EL DL+ E + L+K+LEE + + L E + L E
Sbjct: 771 TLENSN--KKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQET 824
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE---KDLEVIQQN 507
++ EK K L + NK+L Q ++ E N K L+K N+ K++ + +++
Sbjct: 825 SQLEKD-----KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES 879
Query: 508 CYLMAAEDLELRS----------------EGLITEKCSSQQPPGSKTIFSKE-KKQSSDY 550
C + + E + E L++EK +QQ + E +K +
Sbjct: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---KT 607
E L+ + D Y L++S ES +L+ + KI AL +LE+ Q LR KT
Sbjct: 940 ERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQL---- 663
+++ +++R++E + S I E+N + + EL K LI++
Sbjct: 999 VKKNYEALKQRQDEERMVQSSP----PISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054
Query: 664 -------------VKELYTDNQHLKKTIFDL--SCMGFQGNG-----------FPDRLAS 697
+K+L T N +L+ I L + Q + +
Sbjct: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1114
Query: 698 TEQTELL----------ASKEDEDTIKIGEDDEINFLSDQ-----------HLQQSNEIM 736
++ T L+ +S E+E+ I E +++ L D H +Q++E
Sbjct: 1115 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174
Query: 737 KDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESR 792
+SK G ++ E + D + + ++G +L L E+ +LLE++
Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230
Score = 107 bits (267), Expect = 1e-22
Identities = 321/1466 (21%), Positives = 572/1466 (39%), Gaps = 241/1466 (16%)
Query: 40 GNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHI 99
G LP+ S SP + MK E++ L E + K +I R++QE TE +
Sbjct: 220 GLHFLPHASSSAQSPCGSPGMKRTESR-QHLSVELADAKAKI----RRLRQELEEKTEQL 274
Query: 100 YKTNIELKVEVESLKRELQEREQLLIKASKA------VESLAEAG------GSEIQRVKE 147
EL+ LKR QE LL A A +++L E SE+ R KE
Sbjct: 275 LDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE 334
Query: 148 ---DARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK- 203
D +VE+L +LLE + LE GT LE + ++K
Sbjct: 335 RLHDIEFYKARVEELKEDNQVLLE-----TKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 204 KMHEGDLAMALVLDEKDRLIEE-LKLSLKSKEALIQCLK--EEKSQMACPDENVSSGELR 260
K+H+ ++ + + + L+EE + L + K+++ + L E Q++ E +S +
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE-LSEAPQK 448
Query: 261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNS--LKRDK 318
L E +ME+Q + EE ++ + + EK+N K+ +
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 319 AIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ-------KAQTQEFQGSEDYET 371
++ + K + + L+ ++ K A K E L+ K QE + +
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSK 431
+L + +SA R +++ K EN L SIK+ + +LS ++ E+ +++K+LE K K
Sbjct: 569 SLRQRSQISAEARVKDIEK--ENKILHESIKETSSKLSKIEFEKRQIKKELE---HYKEK 623
Query: 432 GDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL--LSESNKKLHNQEQVIKHLTESTNQK 489
G+ E+L NE++ EK E K + L + +K+ EQ L +
Sbjct: 624 GE--------RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
Query: 490 DVLLQKFNEK--DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
L F LE +++ + E+LELR + + KC+S + ++ + ++
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELR-RNVESLKCASMK-------MAQLQLEN 727
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKT 607
+ E + LKK ++ L+A K L + + Q L+KT
Sbjct: 728 KELESEKEQLKKGLEL----------------LKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 608 LEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
LE +I++ E E L + + L LEE ++ E+L+K+ L Q +L
Sbjct: 772 LENSNKKIQQLESELQDLEMENQT-LQKNLEE---LKISSKRLEQLEKENKSLEQETSQL 827
Query: 668 YTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
D + L+K + +Q E+ + +E+ +KIG
Sbjct: 828 EKDKKQLEK----------------ENKRLRQQAEIKDTTLEENNVKIG----------- 860
Query: 728 HLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATL 787
+L++ N K LSK G + C+ L L E L
Sbjct: 861 NLEKEN---KTLSKE-----------------IGIYKESCVR-------LKELEKENKEL 893
Query: 788 LLESRPDL--LKVVRELLLGQLFLTEQEVSG-EHLDGKTEKTPKQKGELVHFVQTNSFSK 844
+ + D+ L +RE L+ + T+Q + E L + EK K L+H Q S
Sbjct: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ--STDD 951
Query: 845 PHDELKLSCEAQLVKAGEV--PKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTA 902
+ L+ E+ L K+ E+ K+ +A ++ LR + + ++ +E A
Sbjct: 952 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE------A 1005
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSR-----LPILIKPSRSLGNMYRLPAT 957
L E + + S P I+ + K R L+K L + R AT
Sbjct: 1006 LKQRQDEERM---------VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQPPVGA 1015
LQ++ L+ +LK+ +T N L +++ + + TL NA+ V
Sbjct: 1057 ------LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110
Query: 1016 AYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSE--ICPPDDLASLPSCKENPEDVL 1073
+ +S ++S+ QQ S E ++E I +DL SL + L
Sbjct: 1111 STLNS--------QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1162
Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE--------TEYLKQK--IHDLETEL 1123
+ S+ + +S GT +S N E + LKQK + DLE L
Sbjct: 1163 E----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1218
Query: 1124 EGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSL---HQVRYV 1180
+ Q + K+ + A LCG +D T+S L +V
Sbjct: 1219 KVEQEKMLLENKNHETVAAEYKKLCGE-------------NDRLNHTYSQLLKETEVLQT 1265
Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKL---QKEQNLNMQLFSEIH-NLQNKFRD 1236
H + L ++ LE +L+EQ +L + N +L S++ NL+ + R
Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
Query: 1237 LSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTM--IKAFEELLQASDVDYCV 1294
L D + + +L Q ++ V RQ+++ + ++ +E L+ +D
Sbjct: 1326 L----LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
Query: 1295 AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPS 1354
+ + K+ KL + K + E L + + + L + + S
Sbjct: 1382 FYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDS 1441
Query: 1355 A---SHALSDYET--SEKSF--------FSRDQKQDNETEKT----SVMVNSFSQDLLME 1397
+ S++L D +T ++KS F R++ +D + K S+ +N Q +++
Sbjct: 1442 SSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLA 1501
Query: 1398 HIQEIRTLRKRLEESIKTNEKLRKQL 1423
T + + I T K RK+L
Sbjct: 1502 GQWTGSTENLEVPDDISTG-KRRKEL 1526
Score = 72.8 bits (177), Expect = 3e-12
Identities = 107/535 (20%), Positives = 227/535 (42%), Gaps = 56/535 (10%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSL-VQSQARELSLQR 1257
L + KQ+LE+ E +L++ Q NM L S+ + + +L R ++ V E+S +
Sbjct: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYK 333
Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFL 1317
+++ D + + + + + LL+ + EG + + ++ EL ++ +L
Sbjct: 334 ERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKA 389
Query: 1318 NGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQD 1377
+ +E + + +E + E+N+T + +S + S + S S S ++
Sbjct: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
Query: 1378 -----NETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI-------KTNEKLRKQLER 1425
NE + ++ L + ++E+RT +E + K N++L K++E
Sbjct: 450 LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
+E VQ S+ + L L E L K + L + + ++EN+ L +++S
Sbjct: 510 LENEIVQEKQSL-QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 1486 ----RKTVSLE----HLQRE----YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
R +S E +++E + S+KE + +L K EK + ++L + + G+
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERA 627
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRD--- 1590
++ E+ ++ K + +L++ + E L++E+ L + + K D F++
Sbjct: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 1591 -LHSLLMEIQAL---RLQLERSIETSSTLQSRL-------------KEQLARGAEKAQEG 1633
L SL E L L+L R++E+ ++ KEQL +G E +
Sbjct: 688 QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Query: 1634 -----ALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSE 1683
L ++ Q + I LQ + +K + ++ + K++ E
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
Score = 72.8 bits (177), Expect = 3e-12
Identities = 153/817 (18%), Positives = 312/817 (38%), Gaps = 99/817 (12%)
Query: 1067 ENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGY 1126
EN + + T + S ++K+ M + E+ S + E L+ +I + L+
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKM---EKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 1127 QNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL 1186
QN L K E I L Q + + +N + T SSL Q +
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQIS----- 577
Query: 1187 GPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDS 1244
A + EN L + ++E KL K + Q+ E+ + + K
Sbjct: 578 ---AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----------- 623
Query: 1245 LVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQ 1304
+A EL + ++ + + Q T +K E ++A +++ ++
Sbjct: 624 --GERAEELENELHHLEKENELL----QKKITNLKITCEKIEA----------LEQENSE 667
Query: 1305 CAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYET 1364
KL+K + K++ ++ + + +++E+NL + + S A E
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 1365 SEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424
E K+ E K S + L Q + +RL+++++ + K +QLE
Sbjct: 728 KELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN---AMLIKGSRDKQKENDKLR 1481
+ + + ++ + EL S + + L K+N++L + L K + +KEN +LR
Sbjct: 784 SELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+ K +LE + ++++EN+ L K E+ +E
Sbjct: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSK---------------------EIGIYKESCV 881
Query: 1542 LRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQAL 1601
++L +N +L++ +++K L E + E K Q DL L E++ +
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLRE------DLVSEKLKTQQMNNDLEKLTHELEKI 935
Query: 1602 RLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPM 1661
L ER + + R K L E + +L + + ++ E L+ + +
Sbjct: 936 GLNKERLLHDEQSTDDRYK-LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994
Query: 1662 ESDNSFDLFDS--SQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLW 1719
E +++ + + V +PP+SG D + S T+ + V +
Sbjct: 995 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDN---KWERESQETTRELLK--VKDRLIE 1049
Query: 1720 ASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKF 1779
+N + + + LKQ+ L + Q S ++ T A L
Sbjct: 1050 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE 1109
Query: 1780 VSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKL 1839
S++++ +L +L L+ + SL + E + + + ++ L+ L + +K
Sbjct: 1110 NSTLNSQSTSLMNQNAQL-LIQQSSLENEN------ESVIKEREDLKSLYDSLIKDHEK- 1161
Query: 1840 QNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLEL 1876
L+L ++ ++ L+ H L+ A NLE+
Sbjct: 1162 ------LELLHERQASEYESLISKHGTLKSAHKNLEV 1192
Score = 69.3 bits (168), Expect = 3e-11
Identities = 260/1409 (18%), Positives = 534/1409 (37%), Gaps = 242/1409 (17%)
Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201
++++K ++ +QQ+ + +L++ K+ + Q GTE K L L L
Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQ--------GTEEVKKLLLLL------ 128
Query: 202 MKKMHEGDLAMALVLDEKDRLIEELK-LSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
L A+ +K+ IE ++ L +K A+ ++E ENV +
Sbjct: 129 --------LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQ----ENVFDLQWM 176
Query: 261 GLCAAPREEKERETEAAQMEHQK---ERNSFEERIQALEEDLREKEREIATEKKNS---- 313
+ +E+ E + + ++ ER+ E I L E+ R+ + ++
Sbjct: 177 EVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEE-RDGLHFLPHASSSAQSPC 235
Query: 314 ----LKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369
+KR ++ Q L++ L + K+ L E+E+ + ++ L++ + + + ++
Sbjct: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 370 ETALSGKEALSAALRSQNL----TKSTENHRLRRSIKKITQELSDLQQERERLEK----- 420
LS +A SA + L K+ +L + + + L D++ + R+E+
Sbjct: 296 MNLLS--DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 421 ----------------------DLEEAHREKSKGDCTIRDL-------RNEVEKLRNE-- 449
L E +E + + D+ R ++E+L E
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 450 ----------------------VNEREKAMENRYKSLLSESNK-------KLHNQEQVIK 480
++ + E KSL E N+ KL + Q +
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 481 HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF 540
E ++ K L++ ++N L ++ +E+ ++ EK S Q
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRL--SKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 541 SKEKKQ--------SSDYEELIQVLKKEQDIYTHLVKSLQE------------------- 573
KEK Q + E I++L++E + V SL++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 574 -SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632
+SI ++L+KI ++Q+++++ Y+ + EE +E+ E+E+ L T+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
C +K+ L Q EL +N+ LKKT+ + FQ
Sbjct: 652 KITC------------------EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 693 DRLASTEQTELLASKEDEDTIKIGEDDEINF-LSDQHLQQSNEIMK---DLSKGGCKNGY 748
+ ++ E L + + +++K L ++ L+ E +K +L K K
Sbjct: 694 KENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
Query: 749 LRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLF 808
+ D + LE + L +E L +E++ L K + EL +
Sbjct: 753 RLEVSYQGLDIENQRLQKTLENSN--KKIQQLESELQDLEMENQ-TLQKNLEELKISSKR 809
Query: 809 LTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELK-LSCEAQLVKAGEVPKVG 867
L + E + L+ +T + K K +L + N + E+K + E VK G + K
Sbjct: 810 LEQLEKENKSLEQETSQLEKDKKQL---EKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 868 LKDASVQTVATEGDLLRFK--HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSL 925
K S + + +R K + +E + I+ R + + Q L
Sbjct: 867 -KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL 925
Query: 926 PGITNREAK----KSRLPILIKPSRSLGNMYRLPATQEVVTQLQS------QILELQGEL 975
+T+ K K R L+ +S + Y+L ++ T +S +I L+ L
Sbjct: 926 EKLTHELEKIGLNKER---LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
Query: 976 KEFKTCNKQLHQKLILAEAVMEG--RPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSV 1033
+E N+QL Q+L + E + ++ ++ + PP+ +D+ E++ +TT +
Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG--EDNKWERESQETTREL 1040
Query: 1034 WRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA-TYLSSKSQPSAKV 1092
+ K+ + +R+ A+L + K+ + L L ++ +
Sbjct: 1041 LKVKDRLIEVERNN------------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 1093 SVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHS--QCSEAIITVLCGT 1150
+V +Q+ ++ T N ++ + ++ QN +Q+ S +E++I
Sbjct: 1089 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148
Query: 1151 EGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQE 1210
+ D L K + +S ++ KH + ++ R LE+ QL +Q+
Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208
Query: 1211 YKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
+L+ + + +++ E L+NK + Y L R Q +K+ V+
Sbjct: 1209 GQLEDLEKM-LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE---VLQ 1264
Query: 1271 RQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQN 1330
H N + LL S ++ E + ++L E+ ++L + + + +
Sbjct: 1265 TDHKN-----LKSLLNNSKLEQTRLEA------EFSKLKEQYQQLDITSTKLNNQCELLS 1313
Query: 1331 ELMERIEEDNLTYQHLLPE-SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389
+L +EE+N +HLL + + L + K F +Q+Q
Sbjct: 1314 QLKGNLEEEN---RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ------------- 1357
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEK 1418
++ + E+R +++LEE I K
Sbjct: 1358 -----YIDKLNELRRQKEKLEEKIMDQYK 1381
Score = 64.7 bits (156), Expect = 8e-10
Identities = 259/1411 (18%), Positives = 543/1411 (38%), Gaps = 233/1411 (16%)
Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
+++ F ERIQ L+ D + E ++ + +Q + + S+E +IE
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--------DIE 187
Query: 343 KLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIK 402
L A + L + + + + G L A S + + S +
Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 403 KITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
++ EL+D + + RL ++LEE + + D + E+E++ E+ K ++
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQ-------LLDCKQELEQMEIEL----KRLQQENM 296
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
+LLS++ ++++ D L +K D + + Y D+E
Sbjct: 297 NLLSDARSARMYRDEL-----------DALREKAVRVDKLESEVSRYKERLHDIEFYKAR 345
Query: 523 LITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQA 582
+ K +Q +KT+ + + + + + L+KE +LQ +++++
Sbjct: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE---------NLQLKAKLHDMEM 396
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
E + RK++E+ L E+ + +++S D++ +L LE+ +R
Sbjct: 397 ERDMD---RKKIEE-----------LMEENMTLEMAQKQSM----DESLHLGWELEQISR 438
Query: 643 F-QVEHFSQEELKKKVSDLIQL-VKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQ 700
++ Q+ L +V++L + +L +NQ L KT+ +L G ++ E+
Sbjct: 439 TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK 498
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760
SK+ ++I E++ + Q LQ + KDL K + L T + +
Sbjct: 499 ENQRLSKK----VEILENEIVQ--EKQSLQNCQNLSKDLMK---EKAQLEKTIETLRENS 549
Query: 761 GAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820
+E +N +++ + E+R ++ ++L + T ++S
Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS----- 604
Query: 821 GKTEKTPKQ-KGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATE 879
K E +Q K EL H+ K+ + E
Sbjct: 605 -KIEFEKRQIKKELEHY--------------------------------KEKGERAEELE 631
Query: 880 GDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLP 939
+L + E E ++K N ++ E AL RE +K
Sbjct: 632 NELHHLEKE--NELLQKKITNLKITCEKIE-----------ALEQENSELERENRK---- 674
Query: 940 ILIKPSRSLGNM-YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEG 998
L K S N+ ++L + ++ +QL + LEL+ ++ K + ++ Q L L +E
Sbjct: 675 -LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELES 732
Query: 999 RPTPDKT---LLNAQ----PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDS 1051
K LL A + +YQ E + ++ T +++ ++ +++S
Sbjct: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT--------LENSNKKIQQLES 784
Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEY 1111
E+ DL + + L +S K S + ++ + E +
Sbjct: 785 EL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK-QLEKENKR 840
Query: 1112 LKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTF 1171
L+Q+ +T LE I L+K ++ I + + L K + +E+
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-----ENKELV- 894
Query: 1172 SSLHQVRYVKHVKILGPLAPEMIDSRV-LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNL 1230
R +K L L +++ ++ + + LE+ ++L+K +L + +
Sbjct: 895 -----KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 1231 QNKFRDLSPPRYDSLVQS---QARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA 1287
++++ L +L +S + +++ ++++ RQ + T+ K +E L Q
Sbjct: 950 DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 1288 SDVDYCVAEG-------------FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELME 1334
D + V QE + ++ ++L ++ N ++ E ++
Sbjct: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069
Query: 1335 RIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL 1394
++E N Q + + S L + T+ ++ ++ Q +++ S + + + L
Sbjct: 1070 QLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 1395 LMEH----------IQEIRTLRKRLEESIKTNEKLRKQLERQGSEF---VQGSTSIFASG 1441
L++ I+E L+ + IK +EKL ERQ SE+ + ++ ++
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187
Query: 1442 SEL---HSSLTSEIHFLRKQNQALNAM--LIKGSRDKQKENDKLRESLSRKTVSL----E 1492
L H L + L KQ L + ++K ++K +K E+++ + L +
Sbjct: 1188 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND 1247
Query: 1493 HLQREYASVKEENERLQKEGSE-KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQND 1551
L Y+ + +E E LQ + K N +++ R E S+++E+ QQL +
Sbjct: 1248 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-EFSKLKEQY---QQLDITST 1303
Query: 1552 KLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQ----LER 1607
KL + + L+EE+R LL +IQ L LQ LE+
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRH--------------------LLDQIQTLMLQNRTLLEQ 1343
Query: 1608 SIETSSTLQSRLKE------QLARGAEKAQE 1632
++E+ ++ +L R EK +E
Sbjct: 1344 NMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
Score = 32.3 bits (72), Expect = 4.5
Identities = 72/333 (21%), Positives = 132/333 (39%), Gaps = 47/333 (14%)
Query: 1310 EKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSF 1369
E+++KL L V+ + E +ERI Q L ++ A+H E F
Sbjct: 119 EEVKKLLLLLLGCAVQCQKKEEFIERI-------QGLDFDTKAAVAAHIQEVTHNQENVF 171
Query: 1370 FSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSE 1429
D + + + M + LL ++ L +E +T +L + ER G
Sbjct: 172 -------DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE--ERDGLH 222
Query: 1430 FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV 1489
F+ ++S S +E Q L+ L D + + +LR+ L KT
Sbjct: 223 FLPHASSSAQSPCGSPGMKRTE------SRQHLSVELA----DAKAKIRRLRQELEEKTE 272
Query: 1490 SLEHLQREYASVKEENERLQKEG------SEKERHNQQLIQEVRCSGQELSRVQEEVKLR 1543
L ++E ++ E +RLQ+E + R + + +R + +++ EV
Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
Query: 1544 QQLLSQNDKLLQSLRV-ELKAYEKLDEEHRRLREASGEGWKGQ-DPFRD----------- 1590
++ L +D RV ELK ++ E + + E EG + + D +
Sbjct: 333 KERL--HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK 390
Query: 1591 LHSLLMEIQALRLQLERSIETSSTLQSRLKEQL 1623
LH + ME R ++E +E + TL+ K+ +
Sbjct: 391 LHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 113 bits (283), Expect = 2e-24
Identities = 146/740 (19%), Positives = 303/740 (40%), Gaps = 124/740 (16%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQ---QEFHGPTEHI--YKTNIE--------LK 107
K +N+I ++K+E + L+ +++ +F +HI K ++ L+
Sbjct: 434 KFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 493
Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167
EV++L+ L+E+E +L K +K ++ +AE G++ + + ++ + D+ +++ +L
Sbjct: 494 TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD-----LKDMLDVKERKVNVL 548
Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK 227
+K + Q +L + EK + S L E K + D D + L+
Sbjct: 549 QKKIENLQEQLR------DKEKQM-----SSLKERVKSLQADTT------NTDTALTTLE 591
Query: 228 LSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS 287
+L KE I+ LKE++ R+E+E++ E ++K+
Sbjct: 592 EALAEKERTIERLKEQRD---------------------RDEREKQEEIDN--YKKDLKD 628
Query: 288 FEERIQALEEDLREKEREIATEKKNS-------LKRDKAIQGLTMALKSKEKKVEELNSE 340
+E++ L+ DL EKE + K+++ LK+D ++ L +AL+ K+++ ++ S+
Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
Query: 341 IEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRS 400
++K +E AL + + + R Q+L R
Sbjct: 689 LKKA------------------------HEAALEARASPEMSDRIQHL---------ERE 715
Query: 401 IKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV---NEREKAM 457
I + E S Q E +RL + L+E EK+ D I +L +V+ +V +E+
Sbjct: 716 ITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775
Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ----QNCYLMAA 513
+ + +L E+ ++ N + L +S +KD +++ E E +Q + L
Sbjct: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
Query: 514 EDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE 573
E +E + E + + + + S + K SS + L + KE + + +
Sbjct: 836 ESARTNAEKQVEELLMAMEKV-KQELESMKAKLSSTQQSLAE---KETHLTNLRAERRKH 891
Query: 574 SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
+ + ++ E K +L + +K +E+++ ++R ++ QT
Sbjct: 892 LEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNR 951
Query: 634 SICLEEN---NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNG 690
+ +N + F+ H +Q K +IQ + EL + LK I L+
Sbjct: 952 MKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTT------- 1004
Query: 691 FPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLR 750
L +L + + +DD+ + ++ ++ +L KG N L+
Sbjct: 1005 ----LCHDRDPLILRGLTPPASYNL-DDDQAAWENELQKMTRGQLQDELEKGERDNAELQ 1059
Query: 751 HTESKISDCDGAHAPGCLEE 770
+ I H P LE+
Sbjct: 1060 EFANAILQQIADHCPDILEQ 1079
Score = 70.9 bits (172), Expect = 1e-11
Identities = 131/684 (19%), Positives = 292/684 (42%), Gaps = 101/684 (14%)
Query: 127 ASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTE 186
AS SL +A + I ++ K+V + DLL K + + E ++++ + K F E
Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQL-KEVLRENDLLRKDVEVKESKLSSSMNSI-KTFWSPE 193
Query: 187 T--EKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEK 244
E+ALR SK++ K+ + V+ E++ + +++++++ + ++ ++ +
Sbjct: 194 LKKERALRKDEASKITIWKEQYR-------VVQEEN---QHMQMTIQALQDELR-IQRDL 242
Query: 245 SQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER 304
+Q+ D + +GE C A E E + EH+++ + + L + L E E
Sbjct: 243 NQLFQQDSSSRTGEP---CVA--ELTEENFQRLHAEHERQA----KELFLLRKTLEEMEL 293
Query: 305 EIATEKKNSLKRDKAIQGLTMALKSK---EKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
I T+K+ RD++I+ L L+SK K EE + +L+ A + +
Sbjct: 294 RIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
Query: 362 EFQGS-------EDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
E + S +E A A + AL++ K ++ + R ++ + +E+ L+
Sbjct: 354 EKENSMLREEMHRRFENA--PDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN 411
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK---AMENRYKSLLSE-SNK 470
++ EE ++ + ++N++ +++ E++ ++ A++ + ++L ++ S+
Sbjct: 412 GALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDS 471
Query: 471 KLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR---SEGLITEK 527
K H +V+K + Q+ +LQ + L LR E ++ +K
Sbjct: 472 KQH--IEVLKESLTAKEQRAAILQ----------------TEVDALRLRLEEKETMLNKK 513
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKI 587
Q + + + D ++++ V +++ ++ +++LQE + + + +++ +
Sbjct: 514 TKQIQDMAEEK--GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE--QLRDKEKQMSSL 569
Query: 588 FALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEH 647
K L+ D + TLEE ++E R E + R + E
Sbjct: 570 KERVKSLQADTTNTDTALTTLEEALAEKERTIERL----------------KEQRDRDER 613
Query: 648 FSQEEL---KKKVSDLIQLVKELYTDNQHLKKTIFDL----SCMGFQGNGFPDRLASTEQ 700
QEE+ KK + DL + V L D + ++ DL S + G RL +
Sbjct: 614 EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL---KT 670
Query: 701 TELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCD 760
E+ ++ E+ +K+ + L++++E + + ++H E +I+
Sbjct: 671 LEIALEQKKEECLKM----------ESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
Query: 761 GAHAPGCLEEGAFINLLAPLFNEK 784
+ E + +L + NEK
Sbjct: 721 DESSKAQAEVDRLLEILKEVENEK 744
Score = 47.8 bits (112), Expect = 1e-04
Identities = 68/281 (24%), Positives = 115/281 (40%), Gaps = 56/281 (19%)
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
M ++ L I L+ +L+E ++ N+ LRK +E + S+ SI
Sbjct: 135 MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI----KTFW 190
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
S + LRK + + + R Q+EN ++ ++++ LQ E ++ N
Sbjct: 191 SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-------MTIQALQDELRIQRDLN 243
Query: 1506 ERLQKEGSEK----------ERHNQQLIQEVRCSGQEL---SRVQEEVKLR----QQLLS 1548
+ Q++ S + E + Q+L E +EL + EE++LR +Q L+
Sbjct: 244 QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
Query: 1549 QNDK-------LLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQAL 1601
D+ +LQS + KA E+ E RRL EA M +
Sbjct: 304 ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAE-----------------MHVH-- 344
Query: 1602 RLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAV 1642
LE +E S L+E++ R E A + A T A+Q V
Sbjct: 345 --HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTV 383
Score = 41.2 bits (95), Expect = 0.010
Identities = 76/397 (19%), Positives = 162/397 (40%), Gaps = 45/397 (11%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
+ENL++QL ++E ++ + L ++ N L ++L + + L+ Q
Sbjct: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE----EALAEKERTIERLKEQ 607
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
+ +D R+ + ++L + + E+ +L E L +
Sbjct: 608 RDRD-------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRD-QKQD 1377
G + T +E+ +E+ L + L ++ E + S + R+ +
Sbjct: 661 GLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 720
Query: 1378 NETEKTSVMVNSFSQDLLMEHIQEIRTLRK-------RLEESIK------TNEKLRKQLE 1424
+E+ K V D L+E ++E+ + LE +K N K ++Q+E
Sbjct: 721 DESSKAQAEV-----DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 775
Query: 1425 RQGS-----EFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN-AMLIKGSRDKQKEND 1478
++ S E + ++ S +L SL + + + +AL ++ I R+ +
Sbjct: 776 KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 835
Query: 1479 KLRESLSRKTV-----SLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL 1533
+ + + K V ++E +++E S+K + Q+ +EKE H L E R +E+
Sbjct: 836 ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 895
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+++E L +S+ D + L EL + +K +E
Sbjct: 896 LEMKQEALL--AAISEKDANIALL--ELSSSKKKTQE 928
Score = 38.5 bits (88), Expect = 0.063
Identities = 77/448 (17%), Positives = 183/448 (40%), Gaps = 33/448 (7%)
Query: 1096 GTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKH-SQCSEAIITVLCGTEGAQ 1154
GT E + + + ++K++ L+ ++E Q + +K S E + ++ T
Sbjct: 525 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 584
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDS--RVLENLKQQLEEQEYK 1212
L+ + +E T L + R + E ID+ + L++LK+++ +
Sbjct: 585 TALTTLEEALAEKERTIERLKEQRDRDERE-----KQEEIDNYKKDLKDLKEKVSLLQGD 639
Query: 1213 LQKEQNLNMQLFSEIHNLQNKF--RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS 1270
L +++ + L +L + +D + ++ + E Q+K H + +
Sbjct: 640 LSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 699
Query: 1271 RQ--HMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGV--- 1324
R M+ I+ E E+ + D + Q ++++ E+L+++E N K +
Sbjct: 700 RASPEMSDRIQHLEREITRYKDE----SSKAQAEVDRLLEILKEVENE-KNDKDKKIAEL 754
Query: 1325 --EMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDN---- 1378
++ QN+ + ++ + + E + + ++S++ S +K D
Sbjct: 755 ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL 814
Query: 1379 -ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI 1437
E + SV + + + +L + K++EE + EK++++LE ++ S+
Sbjct: 815 EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 874
Query: 1438 FASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQRE 1497
+ L + L + + L+ +K L S S+K Q E
Sbjct: 875 AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT-----QEE 929
Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQE 1525
A++K E +RL ++ ++ ++ +L+ +
Sbjct: 930 VAALKREKDRLVQQLKQQTQNRMKLMAD 957
Score = 37.4 bits (85), Expect = 0.14
Identities = 73/456 (16%), Positives = 190/456 (41%), Gaps = 56/456 (12%)
Query: 1196 SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHN-LQNKFRDLSPPRYDSLVQSQARELS 1254
+R L + + E L++++ N L E+H +N ++++ + ++S
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 1255 LQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEK 1314
+ ++D + + + + EE ++ +V ++ + ++ Q + L + +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 1315 LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQ 1374
L + T+ E + D+ + +L ES A + +T + R +
Sbjct: 453 ELL-------ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRA-AILQTEVDALRLRLE 504
Query: 1375 KQDNETEKTSVMVNSFSQ-------------DLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
+++ K + + ++ D+L +++ L+K++E E+LR
Sbjct: 505 EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN---LQEQLRD 561
Query: 1422 QLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLR 1481
+ E+Q S + S+ A + ++LT+ L ++ + + + + RD++++ +++
Sbjct: 562 K-EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEI- 619
Query: 1482 ESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERH------------NQQLIQEVRCS 1529
++ +++ +KE+ LQ + SEKE + L ++ R
Sbjct: 620 ----------DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 669
Query: 1530 GQELS---RVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQD 1586
E++ + +E +K+ QL ++ L++ R + +++ R + E K Q
Sbjct: 670 TLEIALEQKKEECLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKAQA 728
Query: 1587 PFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQ 1622
L +L E++ + ++ I + L+ ++K+Q
Sbjct: 729 EVDRLLEILKEVENEKNDKDKKI---AELERQVKDQ 761
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 858 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 911
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1150
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1208 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1372
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1373 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1421 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKL 1563
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1064
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1237
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1238 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1284
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1340
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1460 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1495 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 616 RRREEE 621
+ + EE
Sbjct: 1545 KTQLEE 1550
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 904 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 942
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 943 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 998 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1086
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1138
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1139 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1419
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1420 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1583
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDER 1609
Score = 79.3 bits (194), Expect = 3e-14
Identities = 124/635 (19%), Positives = 255/635 (40%), Gaps = 129/635 (20%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1376 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1430
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 285 RNSFEERIQA------------------------------------LEEDLREKEREIAT 308
E+ +QA L+ L E E E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 309 EKKN------------------SLKRDKAIQGLTMALKSKEK---KVEELNSEIEKLSAA 347
E+K L+ D AI+G A+K K ++++ E+E A+
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667
Query: 348 ----FAKAREALQKAQTQE---FQGSEDYETALSGK-----------EALSAALRSQNLT 389
FA A+E +KA++ E Q ED A + E L+++L +N
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727
Query: 390 KSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDCT 435
+ E RL I ++ +EL + Q Q+ E+L +L K +
Sbjct: 1728 QD-EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
+ L + ++LR++++E E A+++++KS ++ K+ E+ ++ + +K +
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE---QEAREKQAATKS 1843
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
+KD ++ + L+ ED E + E+ Q G+ + +++ EE +
Sbjct: 1844 LKQKDKKLKE---ILLQVED-----ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 556 VLKKEQDIYTHLVKSLQESDS----INNLQAELNK 586
+ + + L ++ + +++ +N L+++L +
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 893
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1126
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1181 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1352
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1463
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1464 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1516
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1562
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1677
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1678 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1732
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1733 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1782
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1783 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1828
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1889 AEEESQRINANRRKLQR 1905
Score = 77.0 bits (188), Expect = 2e-13
Identities = 218/1220 (17%), Positives = 467/1220 (38%), Gaps = 148/1220 (12%)
Query: 296 EEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREAL 355
EE+++ KE E+ K+ K + LK E+K +L E L +E L
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEEKNLL-------QEQL 896
Query: 356 QKAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHR---LRRSIKKITQELSDL 411
Q A+T+ + +E+ L+ K + L L E R L+ KK+ Q++ DL
Sbjct: 897 Q-AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEV---EKLRNEVNEREKAMENRYKSLLSES 468
+++ E E ++ EK + I+ L +E+ + N++++ K +E R +S+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER----ISDL 1011
Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKC 528
L +E+ K+LT+ N+ + ++ +E ++ + ++ E L+ + EG ++
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKRKLEGDASD-- 1066
Query: 529 SSQQPPGSKTIFSKEKKQSSDYEELIQV----LKKEQDIYTHLVKSLQESDS-INNLQAE 583
+Q + ++ K Q + EE +Q L E + +K ++E + I++LQ +
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 584 LNKIFALRKQLEQ---DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
L+ A R + E+ D+ KT E + ++E + + + L L+E
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 641 NRFQVEHFSQ-EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699
R H +Q +E+++K + Q V+EL + K+ +L D+ T
Sbjct: 1187 TR---SHEAQVQEMRQKHA---QAVEELTEQLEQFKRAKANL-----------DKNKQTL 1229
Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
+ E A E + E+ + Q E+ S G L K+ +
Sbjct: 1230 EKEN-ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN- 1287
Query: 760 DGAHAPGCLEE--GAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGE 817
+ G L E G I L + + ++ L +++ L + R+ L L + E
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 818 HLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGL-KDASVQTV 876
L + ++ + K L + T + + KL A V+A E K K+ T
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 877 ATEGDLLRF-KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKK 935
E + K E T+ +++ + + +++ + ++N E K+
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----------------VSNLEKKQ 1450
Query: 936 SRLPILIKPSRSLGNMY--RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993
+ L+ +++ + Y + + +++ L L L+E ++L + + +
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
A ME L++++ VG + ++ ++T
Sbjct: 1511 AEMED-------LVSSKDDVGKNVHELEKSKRALET------------------------ 1539
Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113
+ + + E ED L T A + + K Q+ + L+
Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSS 1173
+++H+ ETELE + + A +K K D +++ +
Sbjct: 1596 RQLHEYETELEDERK----------------------QRALAAAAKKKLEGDLKDLELQA 1633
Query: 1174 LHQVRYVKH-VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
++ + +K L L +M D R LE+ + +E ++ + L +++ LQ
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 1232 NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVD 1291
R + ++ + EL+ + G ++ + I EE L+ +
Sbjct: 1694 EDLAAAERARKQADLEKE--ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESP 1351
E +++ + + E+L +S + + + +ER ++ + H + +
Sbjct: 1752 M---EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 1352 EPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRL 1409
+ ++ E + +++ E + + + + L ++ +++ R + ++
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
+E + KQL+RQ E + S I A+ +L L + +NA+ K
Sbjct: 1869 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 1470 SRDKQKENDKLRESLSRKTV 1489
R + R S R+ +
Sbjct: 1929 RRGNETSFVPSRRSGGRRVI 1948
Score = 72.4 bits (176), Expect = 4e-12
Identities = 103/466 (22%), Positives = 197/466 (42%), Gaps = 85/466 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1492 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1542
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1543 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1659 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488
E +N + ++ R +ESN+ + + +K N+
Sbjct: 1889 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 65.1 bits (157), Expect = 6e-10
Identities = 174/865 (20%), Positives = 337/865 (38%), Gaps = 141/865 (16%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 908 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 965 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1016 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1064
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1110
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1111 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
L +K + V D+ ET + ++ ++ QKH+Q E
Sbjct: 1168 LRAKREQEVTVLKKALDE--------ETRSHEAQVQEMR-------------QKHAQAVE 1206
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN 1201
+ L + A+ L K K + E + +++LG E+ + +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAG--------ELRVLGQAKQEVEHKK--KK 1256
Query: 1202 LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIK 1261
L+ Q++E + K + +L ++H LQN+ ++ L +++ + + L +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKD--- 1309
Query: 1262 DGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321
+ +S Q +T +ELLQ E+ Q + KL +L S
Sbjct: 1310 ----VASLSSQLQDT-----QELLQ-------------EETRQKLNVSTKLRQLEEERNS 1347
Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+ +++ + E + +E T L +S + A S E E+ ++ +N T+
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-STVEALEEGKKRFQKEIENLTQ 1406
Query: 1382 KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
+ ++ D L + ++ L + +L LE++ +F Q + A
Sbjct: 1407 QYEEKAAAY--DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----LLAEE 1460
Query: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
+ S E R + +A +R+K+ + L +L + E L+R +
Sbjct: 1461 KNISSKYADE----RDRAEA-------EAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL 1561
K E E L + ++ + E+ S + L EE+K + L+ L EL
Sbjct: 1510 KAEMEDLVSSKDDVGKN----VHELEKSKRALETQMEEMKTQ----------LEELEDEL 1555
Query: 1562 KAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSI-ETSSTLQSRLK 1620
+A E+ + E + + KGQ RDL + + + R QL+R + E + L+ K
Sbjct: 1556 QA----TEDAKLRLEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 1621 EQ-LARGAEKAQEGAL-TLAVQAVS 1643
++ LA A+K EG L L +QA S
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADS 1635
Score = 60.1 bits (144), Expect = 2e-08
Identities = 229/1176 (19%), Positives = 445/1176 (37%), Gaps = 175/1176 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 852 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 907 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1018
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1071
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1072 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1112
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1113 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1154 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1213 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1325
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1563 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1737 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER-- 1507
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R
Sbjct: 1843 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1508 -----LQKEGSEKERHNQQLIQEVRCSGQELSRVQE 1538
LQ+E E N+ + +EV +L R E
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1656
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1657 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 55.1 bits (131), Expect = 6e-07
Identities = 100/500 (20%), Positives = 201/500 (40%), Gaps = 70/500 (14%)
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGS---EFVQGSTSIFASGSELHSSLTSEIH 1453
+ +Q+ + +++ E +K E+ QL + + E +Q T ++A E+ L ++
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 1454 FLRKQNQALNAML---------IKGSRDKQK------ENDKLRESLSRKTVSLEHLQREY 1498
L + + A L ++ R K E E +R+ + LE + E
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQ--QLLSQNDKLLQS 1556
K E+E L + + ++ + E R S + +EE K + +L ++++ ++
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 1557 LRVELKAYEKLDEEHRRL-REASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTL 1615
L V LK EK +E +L R+ G+ + DL + + E L++QL + E
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAA 1095
Query: 1616 QSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQA 1675
+RL +++A+ + AL I E+ +G ++ D DS +A
Sbjct: 1096 LARLDDEIAQ-----KNNALK------KIREL-------EGHISDLQED-----LDSERA 1132
Query: 1676 VTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYE 1735
K+ + L G + ++L + + ST L + + + +E
Sbjct: 1133 ARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 1736 ALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLE 1791
A ++++ +Q L E Q + A ++ + T A L+ + + AK +E
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 1792 EAYRRLK-----LLWRVSLPEDGQCPLHCE-------------QIGEMKAEVTKLHKKLF 1833
++L+ L + S E + L+ + + E + + KL K +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 1834 EQEKKLQNTMKLLQLSKRQE 1853
+LQ+T +LLQ RQ+
Sbjct: 1312 SLSSQLQDTQELLQEETRQK 1331
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 865 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 918
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1157
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1215 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1379
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1380 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1428 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKL 1570
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1071
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1244
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1245 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1291
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1347
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1467 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1502 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 616 RRREEE 621
+ + EE
Sbjct: 1552 KTQLEE 1557
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 911 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 949
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 950 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 1005 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1093
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1145
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1146 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1426
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1427 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1590
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDER 1616
Score = 79.3 bits (194), Expect = 3e-14
Identities = 124/635 (19%), Positives = 255/635 (40%), Gaps = 129/635 (20%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1383 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1437
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 285 RNSFEERIQA------------------------------------LEEDLREKEREIAT 308
E+ +QA L+ L E E E+
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 309 EKKN------------------SLKRDKAIQGLTMALKSKEK---KVEELNSEIEKLSAA 347
E+K L+ D AI+G A+K K ++++ E+E A+
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674
Query: 348 ----FAKAREALQKAQTQE---FQGSEDYETALSGK-----------EALSAALRSQNLT 389
FA A+E +KA++ E Q ED A + E L+++L +N
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734
Query: 390 KSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDCT 435
+ E RL I ++ +EL + Q Q+ E+L +L K +
Sbjct: 1735 QD-EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
+ L + ++LR++++E E A+++++KS ++ K+ E+ ++ + +K +
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE---QEAREKQAATKS 1850
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
+KD ++ + L+ ED E + E+ Q G+ + +++ EE +
Sbjct: 1851 LKQKDKKLKE---ILLQVED-----ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 556 VLKKEQDIYTHLVKSLQESDS----INNLQAELNK 586
+ + + L ++ + +++ +N L+++L +
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 900
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1133
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1188 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1359
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1470
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1471 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1523
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1569
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1684
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1685 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1739
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1740 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1789
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1790 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1835
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1896 AEEESQRINANRRKLQR 1912
Score = 77.0 bits (188), Expect = 2e-13
Identities = 218/1220 (17%), Positives = 467/1220 (38%), Gaps = 148/1220 (12%)
Query: 296 EEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREAL 355
EE+++ KE E+ K+ K + LK E+K +L E L +E L
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEEKNLL-------QEQL 903
Query: 356 QKAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHR---LRRSIKKITQELSDL 411
Q A+T+ + +E+ L+ K + L L E R L+ KK+ Q++ DL
Sbjct: 904 Q-AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 412 QQERERLEKDLEEAHREKSKGDCTIRDLRNEV---EKLRNEVNEREKAMENRYKSLLSES 468
+++ E E ++ EK + I+ L +E+ + N++++ K +E R +S+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER----ISDL 1018
Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKC 528
L +E+ K+LT+ N+ + ++ +E ++ + ++ E L+ + EG ++
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMI---SELEVRLKKEEKSRQELEKLKRKLEGDASD-- 1073
Query: 529 SSQQPPGSKTIFSKEKKQSSDYEELIQV----LKKEQDIYTHLVKSLQESDS-INNLQAE 583
+Q + ++ K Q + EE +Q L E + +K ++E + I++LQ +
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 584 LNKIFALRKQLEQ---DVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
L+ A R + E+ D+ KT E + ++E + + + L L+E
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 641 NRFQVEHFSQ-EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699
R H +Q +E+++K + Q V+EL + K+ +L D+ T
Sbjct: 1194 TR---SHEAQVQEMRQKHA---QAVEELTEQLEQFKRAKANL-----------DKNKQTL 1236
Query: 700 QTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDC 759
+ E A E + E+ + Q E+ S G L K+ +
Sbjct: 1237 EKEN-ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN- 1294
Query: 760 DGAHAPGCLEE--GAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGE 817
+ G L E G I L + + ++ L +++ L + R+ L L + E
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 818 HLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGL-KDASVQTV 876
L + ++ + K L + T + + KL A V+A E K K+ T
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 877 ATEGDLLRF-KHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKK 935
E + K E T+ +++ + + +++ + ++N E K+
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL----------------VSNLEKKQ 1457
Query: 936 SRLPILIKPSRSLGNMY--RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993
+ L+ +++ + Y + + +++ L L L+E ++L + + +
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
A ME L++++ VG + ++ ++T
Sbjct: 1518 AEMED-------LVSSKDDVGKNVHELEKSKRALET------------------------ 1546
Query: 1054 CPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLK 1113
+ + + E ED L T A + + K Q+ + L+
Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 1114 QKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSS 1173
+++H+ ETELE + + A +K K D +++ +
Sbjct: 1603 RQLHEYETELEDERK----------------------QRALAAAAKKKLEGDLKDLELQA 1640
Query: 1174 LHQVRYVKH-VKILGPLAPEMID-SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
++ + +K L L +M D R LE+ + +E ++ + L +++ LQ
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 1232 NKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVD 1291
R + ++ + EL+ + G ++ + I EE L+ +
Sbjct: 1701 EDLAAAERARKQADLEKE--ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 1292 YCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESP 1351
E +++ + + E+L +S + + + +ER ++ + H + +
Sbjct: 1759 M---EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 1352 EPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDL--LMEHIQEIRTLRKRL 1409
+ ++ E + +++ E + + + + L ++ +++ R + ++
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
+E + KQL+RQ E + S I A+ +L L + +NA+ K
Sbjct: 1876 KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 1470 SRDKQKENDKLRESLSRKTV 1489
R + R S R+ +
Sbjct: 1936 RRGNETSFVPSRRSGGRRVI 1955
Score = 72.4 bits (176), Expect = 4e-12
Identities = 103/466 (22%), Positives = 197/466 (42%), Gaps = 85/466 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1499 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1549
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1550 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1666 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488
E +N + ++ R +ESN+ + + +K N+
Sbjct: 1896 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 65.1 bits (157), Expect = 6e-10
Identities = 174/865 (20%), Positives = 337/865 (38%), Gaps = 141/865 (16%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 915 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 972 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1023 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1071
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1117
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1118 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
L +K + V D+ ET + ++ ++ QKH+Q E
Sbjct: 1175 LRAKREQEVTVLKKALDE--------ETRSHEAQVQEMR-------------QKHAQAVE 1213
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN 1201
+ L + A+ L K K + E + +++LG E+ + +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAG--------ELRVLGQAKQEVEHKK--KK 1263
Query: 1202 LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIK 1261
L+ Q++E + K + +L ++H LQN+ ++ L +++ + + L +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKD--- 1316
Query: 1262 DGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321
+ +S Q +T +ELLQ E+ Q + KL +L S
Sbjct: 1317 ----VASLSSQLQDT-----QELLQ-------------EETRQKLNVSTKLRQLEEERNS 1354
Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+ +++ + E + +E T L +S + A S E E+ ++ +N T+
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-STVEALEEGKKRFQKEIENLTQ 1413
Query: 1382 KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
+ ++ D L + ++ L + +L LE++ +F Q + A
Sbjct: 1414 QYEEKAAAY--DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----LLAEE 1467
Query: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
+ S E R + +A +R+K+ + L +L + E L+R +
Sbjct: 1468 KNISSKYADE----RDRAEA-------EAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL 1561
K E E L + ++ + E+ S + L EE+K + L+ L EL
Sbjct: 1517 KAEMEDLVSSKDDVGKN----VHELEKSKRALETQMEEMKTQ----------LEELEDEL 1562
Query: 1562 KAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSI-ETSSTLQSRLK 1620
+A E+ + E + + KGQ RDL + + + R QL+R + E + L+ K
Sbjct: 1563 QA----TEDAKLRLEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 1621 EQ-LARGAEKAQEGAL-TLAVQAVS 1643
++ LA A+K EG L L +QA S
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADS 1642
Score = 60.1 bits (144), Expect = 2e-08
Identities = 229/1176 (19%), Positives = 445/1176 (37%), Gaps = 175/1176 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 859 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 914 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1025
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1078
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1079 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1119
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1120 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1161 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1220 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1332
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1570 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1744 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER-- 1507
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R
Sbjct: 1850 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1508 -----LQKEGSEKERHNQQLIQEVRCSGQELSRVQE 1538
LQ+E E N+ + +EV +L R E
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1663
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1664 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 55.1 bits (131), Expect = 6e-07
Identities = 100/500 (20%), Positives = 201/500 (40%), Gaps = 70/500 (14%)
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGS---EFVQGSTSIFASGSELHSSLTSEIH 1453
+ +Q+ + +++ E +K E+ QL + + E +Q T ++A E+ L ++
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 1454 FLRKQNQALNAML---------IKGSRDKQK------ENDKLRESLSRKTVSLEHLQREY 1498
L + + A L ++ R K E E +R+ + LE + E
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQ--QLLSQNDKLLQS 1556
K E+E L + + ++ + E R S + +EE K + +L ++++ ++
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 1557 LRVELKAYEKLDEEHRRL-REASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTL 1615
L V LK EK +E +L R+ G+ + DL + + E L++QL + E
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAA 1102
Query: 1616 QSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQA 1675
+RL +++A+ + AL I E+ +G ++ D DS +A
Sbjct: 1103 LARLDDEIAQ-----KNNALK------KIREL-------EGHISDLQED-----LDSERA 1139
Query: 1676 VTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYE 1735
K+ + L G + ++L + + ST L + + + +E
Sbjct: 1140 ARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 1736 ALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLE 1791
A ++++ +Q L E Q + A ++ + T A L+ + + AK +E
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 1792 EAYRRLK-----LLWRVSLPEDGQCPLHCE-------------QIGEMKAEVTKLHKKLF 1833
++L+ L + S E + L+ + + E + + KL K +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 1834 EQEKKLQNTMKLLQLSKRQE 1853
+LQ+T +LLQ RQ+
Sbjct: 1319 SLSSQLQDTQELLQEETRQK 1338
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 865 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 918
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1038
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1157
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1158 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1214
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1215 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1379
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1380 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1427
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1428 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKL 1570
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1071
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1244
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1245 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1291
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1347
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1467 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1502 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 616 RRREEE 621
+ + EE
Sbjct: 1552 KTQLEE 1557
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 911 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 949
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 950 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 1005 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1093
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1145
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1146 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1426
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1427 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1590
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1591 DEQNEEKRRQLQRQLHEYETELEDER 1616
Score = 79.3 bits (194), Expect = 3e-14
Identities = 130/609 (21%), Positives = 255/609 (41%), Gaps = 81/609 (13%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1383 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1437
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 285 RNSFEERIQALEE-DLR----------EKEREI-ATEKKNSLKRDKAIQGLTMALKSKEK 332
E+ +QA E+ LR + ER++ A +++N KR + L L E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR----RQLQRQLHEYET 1610
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
++E+ + +AA K L+ + Q + E A+ L A ++ + +
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--DFQREL 1668
Query: 393 ENHRLRR-----SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL- 446
E+ R R + K+ ++ L+ + +L++DL A R + + D +L E+
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 447 --RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKF------NE 498
RN + + ++ +E R L E ++ N E + + ++T Q + L + +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 499 KDLEVIQQNCYLMAAEDLELRS-----EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553
K+ QQ + ++ ELRS EG + K S TI + E K + E++
Sbjct: 1789 KNESARQQ----LERQNKELRSKLHEMEGAVKSKFKS-------TIAALEAKIAQLEEQV 1837
Query: 554 IQVLKKEQDIYTHLVKSLQESDS-----INNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
Q +++Q KSL++ D + ++ E ++Q E+ + L++ L
Sbjct: 1838 EQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 609 EEQISEIRR 617
EE E +R
Sbjct: 1894 EEAEEESQR 1902
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 900
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 960
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1133
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1188 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1300
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1301 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1359
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1417
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1470
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1471 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1523
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1524 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1569
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1684
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1685 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1739
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1740 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1789
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1790 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1835
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1896 AEEESQRINANRRKLQR 1912
Score = 72.0 bits (175), Expect = 5e-12
Identities = 102/458 (22%), Positives = 195/458 (42%), Gaps = 85/458 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1499 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1549
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1550 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1666 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1895
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
E +N + ++ R +ESN+ + + +K
Sbjct: 1896 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALK 1932
Score = 65.1 bits (157), Expect = 6e-10
Identities = 174/865 (20%), Positives = 337/865 (38%), Gaps = 141/865 (16%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 915 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 972 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1023 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1071
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1117
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1118 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
L +K + V D+ ET + ++ ++ QKH+Q E
Sbjct: 1175 LRAKREQEVTVLKKALDE--------ETRSHEAQVQEMR-------------QKHAQAVE 1213
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN 1201
+ L + A+ L K K + E + +++LG E+ + +
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAG--------ELRVLGQAKQEVEHKK--KK 1263
Query: 1202 LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIK 1261
L+ Q++E + K + +L ++H LQN+ ++ L +++ + + L +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKD--- 1316
Query: 1262 DGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321
+ +S Q +T +ELLQ E+ Q + KL +L S
Sbjct: 1317 ----VASLSSQLQDT-----QELLQ-------------EETRQKLNVSTKLRQLEEERNS 1354
Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+ +++ + E + +E T L +S + A S E E+ ++ +N T+
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-STVEALEEGKKRFQKEIENLTQ 1413
Query: 1382 KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
+ ++ D L + ++ L + +L LE++ +F Q + A
Sbjct: 1414 QYEEKAAAY--DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----LLAEE 1467
Query: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
+ S E R + +A +R+K+ + L +L + E L+R +
Sbjct: 1468 KNISSKYADE----RDRAEA-------EAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL 1561
K E E L + ++ + E+ S + L EE+K + L+ L EL
Sbjct: 1517 KAEMEDLVSSKDDVGKN----VHELEKSKRALETQMEEMKTQ----------LEELEDEL 1562
Query: 1562 KAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSI-ETSSTLQSRLK 1620
+A E+ + E + + KGQ RDL + + + R QL+R + E + L+ K
Sbjct: 1563 QA----TEDAKLRLEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 1621 EQ-LARGAEKAQEGAL-TLAVQAVS 1643
++ LA A+K EG L L +QA S
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADS 1642
Score = 60.1 bits (144), Expect = 2e-08
Identities = 222/1172 (18%), Positives = 446/1172 (38%), Gaps = 168/1172 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 859 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 914 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1025
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1078
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1079 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1119
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1120 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1161 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1220 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1332
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1450 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1509
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1570 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1744 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R+
Sbjct: 1850 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+ +R + + G+E++ ++ +++
Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1605 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1663
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1664 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Score = 55.1 bits (131), Expect = 6e-07
Identities = 100/500 (20%), Positives = 201/500 (40%), Gaps = 70/500 (14%)
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGS---EFVQGSTSIFASGSELHSSLTSEIH 1453
+ +Q+ + +++ E +K E+ QL + + E +Q T ++A E+ L ++
Sbjct: 866 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925
Query: 1454 FLRKQNQALNAML---------IKGSRDKQK------ENDKLRESLSRKTVSLEHLQREY 1498
L + + A L ++ R K E E +R+ + LE + E
Sbjct: 926 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985
Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQ--QLLSQNDKLLQS 1556
K E+E L + + ++ + E R S + +EE K + +L ++++ ++
Sbjct: 986 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 1557 LRVELKAYEKLDEEHRRL-REASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTL 1615
L V LK EK +E +L R+ G+ + DL + + E L++QL + E
Sbjct: 1046 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAA 1102
Query: 1616 QSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQA 1675
+RL +++A+ + AL I E+ +G ++ D DS +A
Sbjct: 1103 LARLDDEIAQ-----KNNALK------KIREL-------EGHISDLQED-----LDSERA 1139
Query: 1676 VTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYE 1735
K+ + L G + ++L + + ST L + + + +E
Sbjct: 1140 ARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 1736 ALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLE 1791
A ++++ +Q L E Q + A ++ + T A L+ + + AK +E
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 1792 EAYRRLK-----LLWRVSLPEDGQCPLHCE-------------QIGEMKAEVTKLHKKLF 1833
++L+ L + S E + L+ + + E + + KL K +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 1834 EQEKKLQNTMKLLQLSKRQE 1853
+LQ+T +LLQ RQ+
Sbjct: 1319 SLSSQLQDTQELLQEETRQK 1338
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 110 bits (276), Expect = 1e-23
Identities = 159/750 (21%), Positives = 325/750 (43%), Gaps = 121/750 (16%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E+ + T+ R K EN++ EL++++ L L+E++Q E +Y E++V
Sbjct: 858 EDELQKTKERQQKA-ENELKELEQKHSQLTEEKNLLQEQLQAE-----TELYAEAEEMRV 911
Query: 109 EVESLKRELQE---------------REQLLIKASKAVESL---------AEAGGSEIQR 144
+ + K+EL+E +QL + K + + EA ++Q
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 145 VKEDARKKVQQVED----------LLTKRILLLEK---DVTAAQAE----------LEKA 181
K A K++++ED L+K LLE+ D+T AE L+
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK 1031
Query: 182 FAGTETEKALRLRLESK----LSEMKKMHEGDLA-MALVLDEKDRLIEELKLSLKSKEAL 236
+E +RL+ E K L ++K+ EGD + + + I ELK+ L KE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 237 IQCLKEEKSQMACPDENV--SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA 294
+Q N EL G + +E+ + E AA+ + +K++ E ++A
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE-RAARNKAEKQKRDLGEELEA 1150
Query: 295 LEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREA 354
L+ +L + AT+++ KR+ Q +T+ K+ +++ ++++++ A+A E
Sbjct: 1151 LKTELEDTLDSTATQQELRAKRE---QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE 1207
Query: 355 LQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
L + Q ++F+ ++ A L T EN L ++ + Q +++ +
Sbjct: 1208 LTE-QLEQFKRAK-------------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 415 RERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV-------NEREKAMENRYKSLLSE 467
+++LE ++E + S G+ +L ++V KL+NEV NE E K + S
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 468 SNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
S++ QE + + + N L Q E++ Q + + A ++LE L +
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ- 1372
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSL-----QESDSINNLQA 582
S KK+ D+ ++ L++ + + +++L +++ + + L+
Sbjct: 1373 ------------LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK 1420
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
N+ L+++L+ V+ N R + +S + +++ + L +++ + S +E +R
Sbjct: 1421 TKNR---LQQELDDLVVDLDNQR----QLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 643 FQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL-SCMGFQGNGFPD---- 693
+ E +E L + + + ++ +EL N+ LK + DL S G +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 694 -RLASTEQTELLASKED-EDTIKIGEDDEI 721
R T+ E+ E+ ED ++ ED ++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKL 1563
Score = 96.7 bits (239), Expect = 2e-19
Identities = 126/606 (20%), Positives = 254/606 (41%), Gaps = 93/606 (15%)
Query: 43 LLPNVSEETVSPTRARNMKD-FENQITEL-----KKENFNLKLRIYFLEERMQQEFHGPT 96
L N++EE +K+ E+ I+EL K+E +L E+++++ G
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDA 1064
Query: 97 EHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
++ +L+ ++ LK +L ++E+ L A ++ + +++++E
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 157 EDLLTKRILL---------LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK--- 204
EDL ++R L +++ A + ELE T T++ LR + E +++ +KK
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 205 ----MHEGDL-----AMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
HE + A ++E +E+ K + + + Q L++E + +A
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA------- 1237
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
GELR L A +E +EH+K++ E ++Q L+ + ER A K
Sbjct: 1238 -GELRVLGQAKQE----------VEHKKKK--LEAQVQELQSKCSDGERARAELNDKVHK 1284
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
++ +T L E K +L ++ LS+ +E LQ+ Q+ S T L
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS----TKLRQ 1340
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
E +L+ Q + L R I + +LSD +++ + +E K +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
I +L + E+ ++ EK +NR + L + L NQ Q++ +L + + D LL +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKT-KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
E I+ K + ++ KE K S L +
Sbjct: 1460 -------------------------EKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEI 615
L+ +++ L+ ++ + L+AE+ + + + + ++V + ++ LE Q+ E+
Sbjct: 1495 ALEAKEE--------LERTNKM--LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 616 RRREEE 621
+ + EE
Sbjct: 1545 KTQLEE 1550
Score = 92.8 bits (229), Expect = 3e-18
Identities = 195/866 (22%), Positives = 347/866 (40%), Gaps = 148/866 (17%)
Query: 79 LRIYFLEERMQ---QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA-VESL 134
L++ EE MQ E E K ELK E+E +L E + LL + +A E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 135 AEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLR 194
AEA E RV+ A+K Q++E++L + +A LE+ E ++ +L+
Sbjct: 904 AEA---EEMRVRLAAKK--QELEEILHEM-----------EARLEE-----EEDRGQQLQ 942
Query: 195 LESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENV 254
+E KKM + L + L+E++ ++L+L + EA I+ L++E M + +
Sbjct: 943 -----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997
Query: 255 SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSL 314
S KER EERI L +L E+E + K
Sbjct: 998 S---------------------------KERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 315 KRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALS 374
K + I L + LK +EK +EL KL + E + Q Q + + L+
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ----IAELKMQLA 1086
Query: 375 GK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGD 433
K E L AAL + + +N+ L++ I+++ +SDLQ+ DL+ ++K +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKK-IRELEGHISDLQE-------DLDSERAARNKAE 1138
Query: 434 CTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI---KHLTESTNQKD 490
RDL E+E L+ E +E+ S ++ + +++V K L E T +
Sbjct: 1139 KQKRDLGEELEALKTE-------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 491 VLLQKFNEKDLEVIQQ-----NCYLMAAEDLELRSEGLITEKCSSQQP-----PGSKTIF 540
+Q+ +K + +++ + A +L+ + L E + +
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLE----- 595
K+KK + +EL + L +D ++ LQ E+ + + + E
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAEL------NDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 596 --QDVLS----YQNLRKTLEEQI-------SEIRRREEESFSLYSDQTSYLSICLEENNR 642
+DV S Q+ ++ L+E+ +++R+ EEE SL +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTE 702
+ + KKK+ D V+ L + +K I +L+ + ++ A+ ++ E
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT------QQYEEKAAAYDKLE 1419
Query: 703 LLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKIS----- 757
++ ++ DD + L +Q +++ +L K K L E IS
Sbjct: 1420 KTKNRLQQEL-----DDLVVDLDNQ-----RQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 758 DCDGAHAPGCLEEGAFINLLAPLFNE-KATLLLESRPDLLKVVRELLLGQ-----LFLTE 811
+ D A A +E ++L L +A LE +LK E L+ + E
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 812 QEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDA 871
E S L+ + E+ Q EL +Q +K L+L Q +K G+ + L+
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAK----LRLEVNMQALK-GQFER-DLQAR 1583
Query: 872 SVQTVATEGDLLRFKHEATREAWEEK 897
Q L R HE E +E+
Sbjct: 1584 DEQNEEKRRQLQRQLHEYETELEDER 1609
Score = 79.3 bits (194), Expect = 3e-14
Identities = 130/609 (21%), Positives = 255/609 (41%), Gaps = 81/609 (13%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++D + + E ++ N+ ++ LEE + + + L+ + +L +L +
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEE-RNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 120 REQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELE 179
++ L + VE+L E G Q+ E+ ++ ++ K LEK Q EL+
Sbjct: 1376 SKKKLQDFASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRLQQELD 1430
Query: 180 KAFAGTETEKALRLRLESKLSEMKKM-HEGDLAMALVLDEKDR--------------LIE 224
+ ++ L LE K + ++ E + DE+DR L
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 225 ELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKE 284
L+ +L++KE L + K K++M ++ VSS + G E+ +R E E + +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEM---EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 285 RNSFEERIQALEE-DLR----------EKEREI-ATEKKNSLKRDKAIQGLTMALKSKEK 332
E+ +QA E+ LR + ER++ A +++N KR + L L E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR----RQLQRQLHEYET 1603
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
++E+ + +AA K L+ + Q + E A+ L A ++ + +
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--DFQREL 1661
Query: 393 ENHRLRR-----SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL- 446
E+ R R + K+ ++ L+ + +L++DL A R + + D +L E+
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 447 --RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKF------NE 498
RN + + ++ +E R L E ++ N E + + ++T Q + L + +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 499 KDLEVIQQNCYLMAAEDLELRS-----EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553
K+ QQ + ++ ELRS EG + K S TI + E K + E++
Sbjct: 1782 KNESARQQ----LERQNKELRSKLHEMEGAVKSKFKS-------TIAALEAKIAQLEEQV 1830
Query: 554 IQVLKKEQDIYTHLVKSLQESDS-----INNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
Q +++Q KSL++ D + ++ E ++Q E+ + L++ L
Sbjct: 1831 EQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 609 EEQISEIRR 617
EE E +R
Sbjct: 1887 EEAEEESQR 1895
Score = 79.0 bits (193), Expect = 4e-14
Identities = 227/1157 (19%), Positives = 462/1157 (39%), Gaps = 170/1157 (14%)
Query: 258 ELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIA--TEKKNSLK 315
+++ L R+E+E + + +++ KER Q E +L+E E++ + TE+KN L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQ------QKAENELKELEQKHSQLTEEKNLLQ 893
Query: 316 RD--------KAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSE 367
+ + + L +K++++EE+ E+E + LQ + + Q
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML 953
Query: 368 DYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK---DLEE 424
D E L +EA L+ + +T + +L I + + + L +ER+ LE+ DL
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 425 AHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN---------- 474
E+ + + L+N+ E + +E+ R K E + + L + +KL
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 475 --QEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQ 532
Q Q+ + + +++ L D E+ Q+N L +L EG I++ +
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL----EGHISD--LQED 1126
Query: 533 PPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL-NKIFALR 591
+ +K +KQ D E ++ LK T L +L + + L+A+ ++ L+
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALK------TELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 592 KQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSIC----------LEENN 641
K L+++ S+ E Q+ E+R++ ++ ++Q LE+ N
Sbjct: 1181 KALDEETRSH-------EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 642 -------------RFQVEHFSQ------EELKKKVSDLIQLVKELYTDNQHLKKTIFDLS 682
+ +VEH + +EL+ K SD + EL L+ + ++
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT 1293
Query: 683 CMGFQGNGFPDRLA--------STEQTELLASKEDEDTIKIGE-----DDEINFLSDQHL 729
M + G +LA + T+ L +E + + ++E N L DQ L
Sbjct: 1294 GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-L 1352
Query: 730 QQSNEIMKDLSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEG-----AFINLLAPLFNE 783
+ E ++L + N L ++ K+ D A LEEG I L + E
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDF--ASTVEALEEGKKRFQKEIENLTQQYEE 1410
Query: 784 KATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNS 841
KA LE + L+ + L+ L Q VS +L+ K K + E + N
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFDQLLAE-----EKNI 1463
Query: 842 FSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
SK DE + EA+ + E + L A + + + +L E T + + + +
Sbjct: 1464 SSKYADE-RDRAEAE-AREKETKALSLARALEEALEAKEEL-----ERTNKMLKAEMEDL 1516
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
S + +N+H + + AL T E K++L L L AT++
Sbjct: 1517 VSSKDDVGKNVHELEKSKRAL-----ETQMEEMKTQLEELED---------ELQATEDAK 1562
Query: 962 TQLQSQILELQGEL-KEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDS 1020
+L+ + L+G+ ++ + ++Q +K + + T + + AA +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Query: 1021 PGEQKGIK-TTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVA 1079
G+ K ++ S + +E Q R + + D L + + +++ + T+
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQMK----DFQRELEDARASRDEIFA-TAKE 1677
Query: 1080 TYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKI-HDLETELEGYQNFIFQLQKHSQ 1138
+KS A + + D + + + + K+++ +L + L G LQ +
Sbjct: 1678 NEKKAKSL-EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN----ALQDEKR 1732
Query: 1139 CSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRV 1198
EA I L E ++ + SD Q + LA E ++
Sbjct: 1733 RLEARIAQL--EEELEEEQGNMEAMSDRVRKATQQAEQ--------LSNELATERSTAQK 1782
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQ 1258
E+ +QQLE Q N +L S++H ++ + ++ S + + +++ +
Sbjct: 1783 NESARQQLERQ----------NKELRSKLHEMEGAVKS----KFKSTIAALEAKIAQLEE 1828
Query: 1259 QIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
Q++ + + + K +E+L + + +AE ++EQ + +++L++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 1319 GKSVGVEMNTQNELMER 1335
+ +N ++R
Sbjct: 1889 AEEESQRINANRRKLQR 1905
Score = 72.0 bits (175), Expect = 5e-12
Identities = 102/458 (22%), Positives = 195/458 (42%), Gaps = 85/458 (18%)
Query: 84 LEERMQQEFHGPTEHIYKTNIELKVEVESL---KRELQEREQLLIKASKAVESLAEAGGS 140
LEE ++ + E + +TN LK E+E L K ++ + L K+ +A+E+ E
Sbjct: 1492 LEEALEAK-----EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME---- 1542
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF-AGTETEKALRLRLESKL 199
E++ E+ ++Q ED L LE ++ A + + E+ A E + R +L+ +L
Sbjct: 1543 EMKTQLEELEDELQATEDAK----LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 200 SEMKKMHEGDLAM-ALVLDEKDRLIEELK-------LSLKSKEALIQCLKEEKSQMACPD 251
E + E + AL K +L +LK ++K +E I+ L++ ++QM
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 252 ENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKER------- 304
+ A R+E A E++K+ S E + L+EDL ER
Sbjct: 1659 RELEDAR------ASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 305 ---EIATEKKNSLKRDKAIQGLTMALKSKEKKVEE------------------LNSEIEK 343
E+A E +SL A+Q L+++ ++EE + E+
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 344 LSAAFAKAREALQKAQT----------------QEFQGS--EDYETALSGKEALSAALRS 385
LS A R QK ++ E +G+ +++ ++ EA A L
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 386 QNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
Q ++ E +S+K+ ++L ++ + E K E+ + KG+ ++ L+ ++E+
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEE 1888
Query: 446 LRNE---VNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
E +N + ++ R +ESN+ + + +K
Sbjct: 1889 AEEESQRINANRRKLQ-RELDEATESNEAMGREVNALK 1925
Score = 65.1 bits (157), Expect = 6e-10
Identities = 174/865 (20%), Positives = 337/865 (38%), Gaps = 141/865 (16%)
Query: 783 EKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSF 842
E L + +L +++ E+ + L E+E G+ L + +K +Q +L ++
Sbjct: 908 EMRVRLAAKKQELEEILHEM---EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 843 SKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINT 901
++ +L K++ EA++ K L+D + + + + L + + E + N
Sbjct: 965 ARQKLQLEKVTAEAKIKK--------LED-EILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 902 ALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVV 961
A E + +NL + +++S + ++ +KSR L K R L +
Sbjct: 1016 A-EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE-LEKLKRKL---------EGDA 1064
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
+ QI +LQ ++ E K + ++L A A ++ L
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL-------------- 1110
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K I+ D + D D +R+ +E D L + K ED L T+
Sbjct: 1111 ---KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSE 1141
L +K + V D+ ET + ++ ++ QKH+Q E
Sbjct: 1168 LRAKREQEVTVLKKALDE--------ETRSHEAQVQEMR-------------QKHAQAVE 1206
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN 1201
+ L + A+ L K K + E + +++LG E+ + +
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAG--------ELRVLGQAKQEVEHKK--KK 1256
Query: 1202 LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIK 1261
L+ Q++E + K + +L ++H LQN+ ++ L +++ + + L +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT----GMLNEAEGKAIKLAKD--- 1309
Query: 1262 DGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321
+ +S Q +T +ELLQ E+ Q + KL +L S
Sbjct: 1310 ----VASLSSQLQDT-----QELLQ-------------EETRQKLNVSTKLRQLEEERNS 1347
Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+ +++ + E + +E T L +S + A S E E+ ++ +N T+
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-STVEALEEGKKRFQKEIENLTQ 1406
Query: 1382 KTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
+ ++ D L + ++ L + +L LE++ +F Q + A
Sbjct: 1407 QYEEKAAAY--DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----LLAEE 1460
Query: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
+ S E R + +A +R+K+ + L +L + E L+R +
Sbjct: 1461 KNISSKYADE----RDRAEA-------EAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVEL 1561
K E E L + ++ + E+ S + L EE+K + L+ L EL
Sbjct: 1510 KAEMEDLVSSKDDVGKN----VHELEKSKRALETQMEEMKTQ----------LEELEDEL 1555
Query: 1562 KAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSI-ETSSTLQSRLK 1620
+A E+ + E + + KGQ RDL + + + R QL+R + E + L+ K
Sbjct: 1556 QA----TEDAKLRLEVNMQALKGQFE-RDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 1621 EQ-LARGAEKAQEGAL-TLAVQAVS 1643
++ LA A+K EG L L +QA S
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADS 1635
Score = 60.1 bits (144), Expect = 2e-08
Identities = 222/1172 (18%), Positives = 446/1172 (38%), Gaps = 168/1172 (14%)
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E+++ + +E +K E + K+ +L EQ LTE N LQ E E
Sbjct: 852 EEMQAKEDELQKTKERQQKA-----ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDI 563
+ L AA+ EL E ++ + + ++ KK + +L + L++E+
Sbjct: 907 EEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 564 YTHL-VKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIR----RR 618
L ++ + I L+ E+ + +L ++ RK LEE+IS++
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE-------RKLLEERISDLTTNLAEE 1018
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE++ +L + + S+ E R + E S++EL+K L ++L D + I
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK-------LKRKLEGDASDFHEQI 1071
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
DL E LA KE+E + L D+ Q++N + K
Sbjct: 1072 ADLQAQ------------IAELKMQLAKKEEELQAALAR------LDDEIAQKNNALKK- 1112
Query: 739 LSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKV 798
+R E ISD L+E A EK L + LK
Sbjct: 1113 ----------IRELEGHISD---------LQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 799 VRELLLGQLFLTEQEVSGEHLDGKTE-KTPKQKGELVHFVQTNSFSKPHDELKLSCEAQL 857
E L T+QE+ + T K + H Q + H + QL
Sbjct: 1154 ELEDTLDST-ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 858 VKAGEVPKVGLKDASVQTVATEG-DL---LRFKHEATREAWEEKPINTALSAEHRPENLH 913
+ K L D + QT+ E DL LR +A +E +K A E + +
Sbjct: 1213 EQFKRA-KANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 914 G----------VPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMY-RLPATQEVVT 962
G V Q + S+ G+ N K+ IK ++ + ++ +L TQE++
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKA-----IKLAKDVASLSSQLQDTQELLQ 1325
Query: 963 QLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTL--LNAQ---------- 1010
+ Q L + +L++ + L +L + ME + ++ + LN Q
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQL---DEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 1011 --PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQ------QRSYEIDSEICPPDDLASL 1062
V A + QK I+ + + +K D+ + E+D + D+ L
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 1063 PSCKENPEDVLSPTSV------ATYLSSKSQPSAKVSVMGTDQ-------SESINTSNET 1109
S E + + Y + + A+ T E++ E
Sbjct: 1443 VSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL 1502
Query: 1110 E----YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVL-CGTEGAQDGLSKPKNGS 1164
E LK ++ DL + + + +L+K + E + + E +D L ++
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 1165 DGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLF 1224
E+ +L + ++ + ++ A + + L++QL E E +L+ E+
Sbjct: 1563 LRLEVNMQAL-KGQFERDLQ-----ARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 1225 SEIHNLQNKFRDLSPPRYDSL------------VQSQARELSLQRQQIKDGHGICVISRQ 1272
+ L+ +DL ++ +Q+Q ++ + + + + +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 1273 HMNTMIKAFEELLQASDVDYCVAEGFQEQLN-QCAELLEKLEKLFLNGKSVGVEMNTQNE 1331
K+ E L D AE ++Q + + EL E+L ++ E
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1332 LMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNE--TEKTSVMVNS 1389
+ ++EE+ L E E A+SD + + ++ NE TE+++ N
Sbjct: 1737 RIAQLEEE-------LEE--EQGNMEAMSD---RVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
++ L +E+R+ +E ++K+ K + + ++ Q + E ++
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKS--KFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
S L+++++ L +L++ D++K ++ +E + ++ L+R+ +EE++R+
Sbjct: 1843 S----LKQKDKKLKEILLQ-VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+ +R + + G+E++ ++ +++
Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/359 (18%), Positives = 156/359 (43%), Gaps = 51/359 (14%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVE 109
ET +++ E+++ + L++ + L+ + +++ E + +L+ +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597
Query: 110 VESLKRELQ-EREQLLIKASKAVESLAEAGGSEIQ-----RVKEDARKKVQQVEDLLTKR 163
+ + EL+ ER+Q + A+ + + E+Q + +E+A K++++++ +
Sbjct: 1598 LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD- 1656
Query: 164 ILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDEKDRL 222
++++ A+A ++ FA + + LE+ L ++++ + + A EK+ L
Sbjct: 1657 ---FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 223 IEELKLSLKSKEALI--------------QCLKEEKSQMACPDENVSSG-----ELRGLC 263
EEL SL + AL + L+EE+ M + V +L
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 264 AAPREEKER-ETEAAQMEHQ-KERNS-------------------FEERIQALEEDLREK 302
A R ++ E+ Q+E Q KE S E +I LEE + ++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
RE K+ ++DK ++ + + ++ + K E+ + EK +A + + L++A+ +
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Score = 55.1 bits (131), Expect = 6e-07
Identities = 100/500 (20%), Positives = 201/500 (40%), Gaps = 70/500 (14%)
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGS---EFVQGSTSIFASGSELHSSLTSEIH 1453
+ +Q+ + +++ E +K E+ QL + + E +Q T ++A E+ L ++
Sbjct: 859 DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918
Query: 1454 FLRKQNQALNAML---------IKGSRDKQK------ENDKLRESLSRKTVSLEHLQREY 1498
L + + A L ++ R K E E +R+ + LE + E
Sbjct: 919 ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978
Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQ--QLLSQNDKLLQS 1556
K E+E L + + ++ + E R S + +EE K + +L ++++ ++
Sbjct: 979 KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 1557 LRVELKAYEKLDEEHRRL-REASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTL 1615
L V LK EK +E +L R+ G+ + DL + + E L++QL + E
Sbjct: 1039 LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE---LKMQLAKKEEELQAA 1095
Query: 1616 QSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQA 1675
+RL +++A+ + AL I E+ +G ++ D DS +A
Sbjct: 1096 LARLDDEIAQ-----KNNALK------KIREL-------EGHISDLQED-----LDSERA 1132
Query: 1676 VTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYE 1735
K+ + L G + ++L + + ST L + + + +E
Sbjct: 1133 ARNKAEKQKRDL-GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 1736 ALLKQI----SQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLE 1791
A ++++ +Q L E Q + A ++ + T A L+ + + AK +E
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 1792 EAYRRLK-----LLWRVSLPEDGQCPLHCE-------------QIGEMKAEVTKLHKKLF 1833
++L+ L + S E + L+ + + E + + KL K +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 1834 EQEKKLQNTMKLLQLSKRQE 1853
+LQ+T +LLQ RQ+
Sbjct: 1312 SLSSQLQDTQELLQEETRQK 1331
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 110 bits (275), Expect = 1e-23
Identities = 332/1692 (19%), Positives = 665/1692 (39%), Gaps = 237/1692 (14%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQ--EFHGPTEHIYKTNIELKVEVESLKR 115
+ + + ++ +E +L+L + L +++ E + E NI ++ + K
Sbjct: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
Query: 116 ELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
EL+ ++ LI+ ++ + E +++R+ E ++ +L K L DV+
Sbjct: 119 ELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
Query: 176 AELEKAFAGTETEKALRLRLESKLS-EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKE 234
E E EK L + L+ E+K + LA+ EK I ELK +L++K+
Sbjct: 179 REKR-----LEQEKELLHSQNTWLNTELKTKTDELLALGR---EKGNEILELKCNLENKK 230
Query: 235 ALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKER--------- 285
+ L+E+ + + +E++ + L +E KE++ + H +
Sbjct: 231 EEVSRLEEQMNGLKTSNEHLQK-HVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLY 289
Query: 286 NSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK-SKEKKVEELNSEIEKL 344
S + +A +L E+ K + + +KAIQ + ++ SK++ +E+ +I +L
Sbjct: 290 KSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRL 349
Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKI 404
A + L + + SE+ A+S A A + + K TE L + +
Sbjct: 350 EKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGM-KLTE---LYNAYVET 405
Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL 464
+L + E +R+ K L+E +E ++ R E E+ + V +E K +
Sbjct: 406 QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
Query: 465 --LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEG 522
L E K + Q V+ ++D + KDL Q ++ E E R
Sbjct: 466 QRLQEDTDKANKQSSVL--------ERDNRRMEIQVKDLS---QQIRVLLMELEEARGNH 514
Query: 523 LIT-EKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQ 581
+I E+ SS S + S+ + EEL Q + Q + L + L E+ +
Sbjct: 515 VIRDEEVSSADISSSSEVISQHLVSYRNIEELQQ---QNQRLLVAL-RELGETREREEQE 570
Query: 582 AELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRR--REEESFSLYSDQTSYLSICLEE 639
+KI L+ +LE + + LRK+ + Q+ + R+ + + + QT+ ++I L
Sbjct: 571 TTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHA 630
Query: 640 NNRFQV---------------------------EHFSQEELKKKVSDLIQLVKELYTDNQ 672
++ V E + K++ ++ + K+ +N+
Sbjct: 631 SSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENE 690
Query: 673 -----HLKKTIFDLSCMGFQGNGFPDRLA-STEQTELLASKEDEDTIKIGEDDEINFLSD 726
L+K ++ + Q +L ++++ E+L + +I E N
Sbjct: 691 KIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLT 750
Query: 727 QHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLL-APLFNEKA 785
Q+ +I+ +++ LR K++ + A +E + L L ++
Sbjct: 751 ATTQKQEQIINTMTQD------LRGANEKLAVAE-VRAENLKKEKEMLKLSEVRLSQQRE 803
Query: 786 TLLLESRPDLLKVV----------------RELLLGQLFLTEQEVSGEHLDGKTEKTPKQ 829
+LL E R L + ++ L Q+ E E+S HL K E +Q
Sbjct: 804 SLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEIS--HLKKKLENEVEQ 861
Query: 830 KGEL-----VHFVQTNSFSKPHDELKLSCEAQLVKAGE---VPKVGLKDASVQTVATEGD 881
+ L V + T L L+ + L A + K L + VQ VA++
Sbjct: 862 RHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQ-VASQSS 920
Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLH--------GVPGWQAALLSLPGITNREA 933
K + + + + ++ E + +L V +QA + SL N+E
Sbjct: 921 QRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEK 980
Query: 934 KKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAE 993
+ + RL + E TQL+ +++E++ E +E + ++ E
Sbjct: 981 Q-------VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRA------IE 1027
Query: 994 AVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEI 1053
++ + KTL + Q V A Q + T S + D +Q ++++
Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRA-------STALSNEQQARRDCQEQAKIAVEAQN 1080
Query: 1054 CPPDDL----ASLPSCKENPEDVLSPTSVATYLSSKSQP--SAKVSVMGTDQSESINTSN 1107
+L A + + + E V SV +L +Q S + + + +
Sbjct: 1081 KYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKD 1140
Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167
E + DLE QN + Q + + +V G +G + +S + G E
Sbjct: 1141 EVSKCVCRCEDLEK-----QNRLLHDQIEKLSDKVVASVKEGVQGPLN-VSLSEEGKSQE 1194
Query: 1168 EMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEI 1227
++ L +R+++ K + E+ L +Q++E E +LQ E+
Sbjct: 1195 QI----LEILRFIRREKEIAETRFEVAQVESLR-YRQRVELLERELQ-----------EL 1238
Query: 1228 HNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA 1287
+ N R+ VQ A+ ++ + +K + V+ N M++ +E L+
Sbjct: 1239 QDSLNAEREK--------VQVTAKTMAQHEELMKKTETMNVV--METNKMLREEKERLE- 1287
Query: 1288 SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER----IEEDNLTY 1343
+ L Q + KLE L + E++ ++ +++ +EED +
Sbjct: 1288 ------------QDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRW 1335
Query: 1344 ----QHLLPESPEPSASH---ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLM 1396
QHL+ + +P LS+ E K R Q+ E + + + S L
Sbjct: 1336 KARNQHLVSQQKDPDTEEYRKLLSEKEVHTK----RIQQLTEEIGRLKAEI-ARSNASLT 1390
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR 1456
+ I++L++ L + E ++K L+ + + +Q ++ ++ L+
Sbjct: 1391 NNQNLIQSLKEDLNKVRTEKETIQKDLDAKIID-IQEKVKTITQVKKIGRRYKTQYEELK 1449
Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKE 1516
Q + + S D Q+++ ++E K +L + + S++ + E LQK SEKE
Sbjct: 1450 AQQDKVMETSAQSSGDHQEQHVSVQEMQELKE-TLNQAETKSKSLESQVENLQKTLSEKE 1508
Query: 1517 RHNQQLIQEVRCSGQELSRVQ--------EEVKLRQQLLSQNDKLLQSLRVELKA----- 1563
+ L ++ ELSR++ +E +LRQQ+ + +K +++ V K+
Sbjct: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAI-VAAKSKIAHL 1567
Query: 1564 ---YEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK 1620
++L +E+ L++ +G + +D L + I AL+ Q E I S L+ L+
Sbjct: 1568 AGVKDQLTKENEELKQRNGALDQQKD------ELDVRITALKSQYEGRI---SRLERELR 1618
Query: 1621 EQLARGAEKAQE 1632
E R E+ E
Sbjct: 1619 EHQERHLEQRDE 1630
Score = 100 bits (249), Expect = 1e-20
Identities = 168/750 (22%), Positives = 314/750 (41%), Gaps = 102/750 (13%)
Query: 54 PTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESL 113
P+ ++ D +Q+ + +++ +LK R+ ++Q T N E +V E +
Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQV-TEEV 986
Query: 114 KRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTA 173
++ ++ R + + +E E Q +++D R+ ++ +E L++ L+K +++
Sbjct: 987 RKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSE----LKKTLSS 1042
Query: 174 AQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
Q E+++A T + + E K + ++ +++ EL L
Sbjct: 1043 VQNEVQEALQRASTALSNEQQARRDCQEQAK---------IAVEAQNKYERELMLHAADV 1093
Query: 234 EALIQCLKEEKSQMACP----DENVSSGELRGL-CAAPREEKER--ETEAAQM-----EH 281
EAL Q KE+ S+MA +E E + L C A EE+ER + E ++ +
Sbjct: 1094 EAL-QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDL 1152
Query: 282 QKERNSFEERIQALEEDLREKEREIATEKKN-SLKRDKAIQGLTMALKS---KEKKVEEL 337
+K+ ++I+ L + + +E N SL + Q + + +EK++ E
Sbjct: 1153 EKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAET 1212
Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTE---- 393
E+ ++ + + R L + + QE Q S + E A + A + + L K TE
Sbjct: 1213 RFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMA-QHEELMKKTETMNV 1271
Query: 394 ----NHRLRRSIKKITQELSDLQQERERLEKD---LEEAHREKSKGDCTIRDLRNEVE-- 444
N LR +++ Q+L +Q + +LE D L+EA+ E S+ ++ + +E
Sbjct: 1272 VMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEED 1331
Query: 445 ----KLRNE--VNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
K RN+ V++++ Y+ LLSE K++H + I+ LTE + + + N
Sbjct: 1332 VKRWKARNQHLVSQQKDPDTEEYRKLLSE--KEVHTKR--IQQLTEEIGRLKAEIARSNA 1387
Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEK------------KQ 546
QN EDL + TEK + Q+ +K I +EK +
Sbjct: 1388 SLTN--NQNLIQSLKEDLNK----VRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRY 1441
Query: 547 SSDYEELIQVLKKEQDIYTHLVKSLQES----DSINNLQAELNKIFALRKQLEQDVLSYQ 602
+ YEEL K + QE + L+ LN+ K LE V +
Sbjct: 1442 KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV---E 1498
Query: 603 NLRKTLEEQISEIRRREEESFSLYSD-----QTSYLSICLEENNRFQVEHFSQE------ 651
NL+KTL E+ +E R +E++ L S+ Q EE R Q+ ++
Sbjct: 1499 NLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIV 1558
Query: 652 ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDED 711
K K++ L + +L +N+ LK Q NG D+ + A K +
Sbjct: 1559 AAKSKIAHLAGVKDQLTKENEELK-----------QRNGALDQQKDELDVRITALKSQYE 1607
Query: 712 TIKIGEDDEINFLSDQHLQQSNEIMKDLSK 741
+ E+ ++HL+Q +E + +K
Sbjct: 1608 GRISRLERELREHQERHLEQRDEPQEPSNK 1637
Score = 60.5 bits (145), Expect = 2e-08
Identities = 88/423 (20%), Positives = 188/423 (44%), Gaps = 35/423 (8%)
Query: 46 NVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEE--RMQQEFHGPTEHIYKTN 103
N E V T A+ M E + + + N ++ EE R++Q+ + K
Sbjct: 1243 NAEREKVQVT-AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE 1301
Query: 104 IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDAR-------KKVQQV 156
+++ + ++ EL E+ +L K +E + + Q + + +K+
Sbjct: 1302 LDI-LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE 1360
Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM---KKMHEGDLAMA 213
+++ TKRI L +++ +AE+ ++ A + L L+ L+++ K+ + DL
Sbjct: 1361 KEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK 1420
Query: 214 LV-LDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER 272
++ + EK + I ++K + + + LK ++ ++ SSG+ + + +E +E
Sbjct: 1421 IIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQ-SSGDHQEQHVSVQEMQEL 1479
Query: 273 ETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEK 332
+ Q E + + S E +++ L++ L EKE E ++ +++ + L L+ +
Sbjct: 1480 KETLNQAETKSK--SLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTT 1537
Query: 333 KVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST 392
+ E+L +I + KA A K++ G +D T KE R+ L +
Sbjct: 1538 QEEQLRQQITEKEEKTRKAIVA-AKSKIAHLAGVKDQLT----KENEELKQRNGALDQQK 1592
Query: 393 ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE 452
+ +R IT S + RLE++L E H+E+ + R+E ++ N+V E
Sbjct: 1593 DELDVR-----ITALKSQYEGRISRLERELRE-HQERH------LEQRDEPQEPSNKVPE 1640
Query: 453 REK 455
+++
Sbjct: 1641 QQR 1643
Score = 58.5 bits (140), Expect = 6e-08
Identities = 253/1372 (18%), Positives = 528/1372 (38%), Gaps = 204/1372 (14%)
Query: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
EK + + SEI+ L K R K ++++ + + S + ++ Q+L
Sbjct: 26 EKFLADQQSEIDGL-----KGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRL 80
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
E +L +K +T++ +L+ ++R + R K + + RDL E+L E+
Sbjct: 81 ELE--KLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQEL 138
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYL 510
L+E K+L+ + L ES K L K +E L
Sbjct: 139 ------------EYLTEDVKRLNEK------LKESNTTKGELQLKLDE-----------L 169
Query: 511 MAAE-DLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVK 569
A++ ++ R + L EK + T + E K +D EL+ + +++ + L
Sbjct: 170 QASDVSVKYREKRLEQEK---ELLHSQNTWLNTELKTKTD--ELLALGREKGNEILELK- 223
Query: 570 SLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQ 629
NL+ + ++ L +Q+ S ++L+K +E+ +++++ +E+ S+
Sbjct: 224 --------CNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKF 275
Query: 630 TSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGN 689
+ L+ ++ +N ++ + ++ + K ++L + V+EL+ + LK+ G
Sbjct: 276 HNELNAHIKLSNLYK---SAADDSEAKSNELTRAVEELH---KLLKEA-------GEANK 322
Query: 690 GFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYL 749
D L EQ++ E E KIG ++ L+ +N+++ + K L
Sbjct: 323 AIQDHLLEVEQSK--DQMEKEMLEKIGR-------LEKELENANDLLSATKR---KGAIL 370
Query: 750 RHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFL 809
E A ++ G + L + E LL + + ++ + L +
Sbjct: 371 SEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYL---DEIV 427
Query: 810 TEQEVSGEHLDGKTEKTPK-QKGELVHFVQTNSFSKPHDELKLSCE------AQLVKAGE 862
E E L + E+ + QK V+ K L+ + + L +
Sbjct: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNR 487
Query: 863 VPKVGLKDAS--VQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQA 920
++ +KD S ++ + E + R H +E+ + +S+ + H
Sbjct: 488 RMEIQVKDLSQQIRVLLMELEEARGNHVIR----DEEVSSADISSSSEVISQH------- 536
Query: 921 ALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKT 980
L+S I + + RL + ++ T +T+LQ L+L+ L E +
Sbjct: 537 -LVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQ---LKLESALTELEQ 592
Query: 981 CNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMD 1040
K ++ L ++++ R D + G A P + S K
Sbjct: 593 LRKSRQHQMQLVDSIVRQR---DMYRILLSQTTGVAI---PLHASSLDDVSLASTPKRPS 646
Query: 1041 SDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPS--AKVSVMGTD 1098
+ Q S + + + + +++ + K Q K+ TD
Sbjct: 647 TSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTD 706
Query: 1099 -QSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQ--------CSEAIITVLCG 1149
+S++ S + ++ ++ L+ +EGY+ I L + +Q + I T+
Sbjct: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQD 766
Query: 1150 TEGAQDGLSKPKNGSDG--EEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENL----- 1202
GA + L+ + ++ +E L +VR + + L LA + + +L NL
Sbjct: 767 LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESL--LAEQRGQNLLLTNLQTIQG 824
Query: 1203 ---------KQQLEEQEYKLQKE-QNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARE 1252
KQ+L Q KL+ E +L +L +E+ R+L D+ Q E
Sbjct: 825 ILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT-E 883
Query: 1253 LSLQ---RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
+L ++ +K+ +QH++ M E+ AS +G +L+
Sbjct: 884 TNLHLNTKELLKNAQKEIATLKQHLSNM-----EVQVASQSSQRTGKGQPSNKEDVDDLV 938
Query: 1310 EKLEKLFLNGKSVGVEMNTQNELMERIE--EDNLTYQHLLPESPEPSASHALSDYETSEK 1367
+L + N+L ER++ N+ + S E S + E K
Sbjct: 939 SQLRQ----------TEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRK 988
Query: 1368 SFFSRDQKQ---DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLE 1424
+ R ++ + EK + V Q+L + + I ++ ++L E KT ++ +++
Sbjct: 989 NIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQ 1048
Query: 1425 RQGSEFVQGSTSIFASGSELHSSLTSEIHF-LRKQNQ--------ALNAMLIKGSRDKQK 1475
E +Q +++ ++ + + + QN+ A + ++ ++++
Sbjct: 1049 ----EALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVS 1104
Query: 1476 ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEK--------ERHNQQLIQEV- 1526
+ +R+ L T E E + EE ER+ K+ K E+ N+ L ++
Sbjct: 1105 KMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIE 1164
Query: 1527 RCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQD 1586
+ S + ++ V+E V+ L SL E K+ E++ E R +R +
Sbjct: 1165 KLSDKVVASVKEGVQ---------GPLNVSLSEEGKSQEQILEILRFIRR--------EK 1207
Query: 1587 PFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLA 1638
+ + ++++LR + + +E L++ L EK Q A T+A
Sbjct: 1208 EIAETRFEVAQVESLRYR--QRVELLERELQELQDSLNAEREKVQVTAKTMA 1257
Score = 57.0 bits (136), Expect = 2e-07
Identities = 273/1418 (19%), Positives = 544/1418 (38%), Gaps = 228/1418 (16%)
Query: 537 KTIFSKEKKQSSDYEELIQVLK--------KEQDIYTHLVKSLQESDSINNLQAELNKIF 588
K++ +K +K +D + I LK + + Y + K L S L E +
Sbjct: 19 KSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE--RLVNETRECQ 76
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHF 648
+LR +LE+ N K L E+ E+ ++ + ++ S T
Sbjct: 77 SLRLELEK----LNNQLKALTEKNKELEIAQDRNIAIQSQFTR----------------- 115
Query: 649 SQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE 708
++EEL+ + DLI+ + L + ++L + + L+ + N L Q +L +
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGEL----QLKLDELQA 171
Query: 709 DEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCL 768
+ ++K E + L+Q E++ +N +L +TE K + D A G
Sbjct: 172 SDVSVKYRE---------KRLEQEKELLHS------QNTWL-NTELK-TKTDELLALGRE 214
Query: 769 EEGAFINLLAPLFNEKATLL-LESRPDLLKVVRELLLGQL--FLTEQEVSGEHLDGKTEK 825
+ + L L N+K + LE + + LK E L + LT+ + + E EK
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
Query: 826 TPKQKGELVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRF 885
+ H +N + D+ + +L +A E LK+A A + LL
Sbjct: 275 FHNELN--AHIKLSNLYKSAADDSEAKSN-ELTRAVEELHKLLKEAGEANKAIQDHLLEV 331
Query: 886 KHEATREAWEEKPINTALSAEHRPEN---LHGVPGWQAALLSLPGITNREAKKSRLPILI 942
E +++ E++ + E EN L + A+LS + + + ++
Sbjct: 332 --EQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389
Query: 943 KPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTP 1002
KP L T+L + +E Q +L K NK++++ L E V E
Sbjct: 390 KPGMKL-------------TELYNAYVETQDQLLLEKLENKRINK--YLDEIVKE----- 429
Query: 1003 DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEID-----SEICPPD 1057
+ A+ P+ ++ + + SV ++ M Q+ + D S + D
Sbjct: 430 ----VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERD 485
Query: 1058 DLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIH 1117
+ K+ + + L + + + V+ ++ S + S+ +E + Q
Sbjct: 486 NRRMEIQVKDLSQQI-------RVLLMELEEARGNHVIRDEEVSSADISSSSEVISQ--- 535
Query: 1118 DLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQV 1177
L Y+N I +LQ+ +Q + L T ++ +E T S + ++
Sbjct: 536 ----HLVSYRN-IEELQQQNQRLLVALRELGETREREE-----------QETTSSKITEL 579
Query: 1178 RYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDL 1237
+ LE+ +LE+ L+K + MQL I ++ +R L
Sbjct: 580 QLK------------------LESALTELEQ----LRKSRQHQMQLVDSIVRQRDMYRIL 617
Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG 1297
L Q+ + L + D + + S + + ++ A
Sbjct: 618 -------LSQTTGVAIPLHASSLDD---VSLASTPKRPSTSQTVSTPAPVPVIESTEAIE 667
Query: 1298 FQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEED--NLTYQHLLPESPEPSA 1355
+ L Q E+ E +K + + QNE +E+++E +L Q+ + A
Sbjct: 668 AKAALKQLQEIFENYKKEKAENEKI------QNEQLEKLQEQVTDLRSQNTKISTQLDFA 721
Query: 1356 SHA-------LSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEH----IQEIRT 1404
S + Y S R+QK T+K ++N+ +QDL + + E+R
Sbjct: 722 SKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 1405 LR-KRLEESIKTNE-KLRKQ------------------------LERQGSEFVQGSTS-- 1436
K+ +E +K +E +L +Q LER +E Q +S
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQI 841
Query: 1437 --IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEND------KLRESLSRKT 1488
+ S L L +E+ + L+ L+ R E + +L ++ ++
Sbjct: 842 EKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEI 901
Query: 1489 VSL-EHLQREYASVKEENERLQKEGSEKERHN-QQLIQEVRCSGQELSRVQEEVKLRQQL 1546
+L +HL V ++ + +G + + L+ ++R + ++++ ++E +K
Sbjct: 902 ATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN 961
Query: 1547 LSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFR-DLHSLLMEIQALRLQL 1605
+ Q ++ SL L +++ EE R+ E K F+ L LME++ + +L
Sbjct: 962 VEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR---LKESAEFQTQLEKKLMEVEKEKQEL 1018
Query: 1606 E----RSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPM 1661
+ R+IE+ S LK+ L+ + QE AL A A+S E + D + K +
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQE-ALQRASTALS-NEQQARRDCQEQAKIAV 1076
Query: 1662 ESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWAS 1721
E+ N ++ + V + S T+ S+L+ W
Sbjct: 1077 EAQNK---YERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEE 1133
Query: 1722 KNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVS 1781
+ R + + + + + RLL + + + ++ +E G +GP LS+
Sbjct: 1134 RE-RMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE-GVQGPLNVSLSEEGK 1191
Query: 1782 SVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQN 1841
S L R ++ + + +++ ++ E+ +L L + +K+Q
Sbjct: 1192 SQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQV 1251
Query: 1842 TMKLL----QLSKRQEKVIFDQLVVTHKILRKARGNLE 1875
T K + +L K+ E + + ++ T+K+LR+ + LE
Sbjct: 1252 TAKTMAQHEELMKKTETM--NVVMETNKMLREEKERLE 1287
Score = 49.3 bits (116), Expect = 4e-05
Identities = 87/404 (21%), Positives = 166/404 (41%), Gaps = 47/404 (11%)
Query: 1268 VISRQHMNTMIKAFEELL------QASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKS 1321
V+ R +N + K+ + L Q S++D + ++ + E ++L + +
Sbjct: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 1322 VGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETE 1381
+ E L +E+ N + L ++ E + D + +S F+R K++ E E
Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQ---DRNIAIQSQFTRT-KEELEAE 123
Query: 1382 KTSVMVNSFSQDLLMEHIQE-IRTLRKRLEESIKTNEKLRKQL-ERQGSEFVQGSTSIFA 1439
K ++ + +E++ E ++ L ++L+ES T +L+ +L E Q S+
Sbjct: 124 KRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASD---------V 174
Query: 1440 SGSELHSSLTSEIHFLRKQNQALNAML-------IKGSRDKQKENDKLRESLSRKTVSLE 1492
S L E L QN LN L + R+K E +L+ +L K +
Sbjct: 175 SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVS 234
Query: 1493 HLQREYASVKEENERLQKEGSE-----KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLL 1547
L+ + +K NE LQK + KE QQ E + + + +KL
Sbjct: 235 RLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNE----LNAHIKLSNLYK 290
Query: 1548 SQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQ--- 1604
S D +A E+L H+ L+EA QD ++ +++ L+
Sbjct: 291 SAADDSEAKSNELTRAVEEL---HKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIG 347
Query: 1605 -LERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEV 1647
LE+ +E ++ L S K +GA ++E ++ A ++ ++
Sbjct: 348 RLEKELENANDLLSATKR---KGAILSEEELAAMSPTAAAVAKI 388
Score = 45.4 bits (106), Expect = 5e-04
Identities = 65/283 (22%), Positives = 125/283 (44%), Gaps = 42/283 (14%)
Query: 411 LQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNK 470
LQQ ER E + + ++K + + D ++E++ L+ + + E +Y E K
Sbjct: 5 LQQVLERTELN-KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQY----FEIEK 59
Query: 471 KL-HNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCS 529
+L H+QE+++ E + + + L+K N + + ++N L A+D + + T +
Sbjct: 60 RLSHSQERLVNETRECQSLR-LELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT-RTK 117
Query: 530 SQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA 589
+ + + ++ S + E L + +K+ L + L+ES N + EL
Sbjct: 118 EELEAEKRDLIRTNERLSQELEYLTEDVKR-------LNEKLKES---NTTKGEL----- 162
Query: 590 LRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQT-----------SYLSICLE 638
QL+ D L ++ E +R E+E L+S T L++ E
Sbjct: 163 ---QLKLDELQASDVSVKYRE-----KRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 639 ENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
+ N + E K++VS L + + L T N+HL+K + DL
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL 257
Score = 43.1 bits (100), Expect = 0.003
Identities = 71/295 (24%), Positives = 135/295 (45%), Gaps = 51/295 (17%)
Query: 386 QNLTKSTENHRLRRSIK-KITQELSDLQQERERLEKDLEEAHREKSKGDCTI-RDLRNEV 443
Q + + TE ++L +S++ K+ + L+D Q E + L+ E+ E + I + L +
Sbjct: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
Query: 444 EKLRNEVNERE------KAMENRYKSLLSESNKKLH-NQEQVIKHLTESTNQKDVLLQKF 496
E+L NE E + + + N+ K+L +E NK+L Q++ I ++ T K+ L +
Sbjct: 66 ERLVNETRECQSLRLELEKLNNQLKAL-TEKNKELEIAQDRNIAIQSQFTRTKEEL--EA 122
Query: 497 NEKDLEVIQQNCYLMAAEDLELRSEGL--ITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
++DL I+ N L +++LE +E + + EK + ++ Q+SD
Sbjct: 123 EKRDL--IRTNERL--SQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKY 178
Query: 555 QVLKKEQDIYTHLVKSLQESDSI---NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQ 611
+ + EQ+ K L S + L+ + +++ AL ++ ++L L+ LE +
Sbjct: 179 REKRLEQE------KELLHSQNTWLNTELKTKTDELLALGREKGNEILE---LKCNLENK 229
Query: 612 ISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKE 666
E+ R EE+ L + S E L+K V DL+ +KE
Sbjct: 230 KEEVSRLEEQMNGLKT---------------------SNEHLQKHVEDLLTKLKE 263
Score = 40.8 bits (94), Expect = 0.013
Identities = 85/400 (21%), Positives = 161/400 (40%), Gaps = 49/400 (12%)
Query: 1473 KQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE 1532
++ E +KL +S+ K L++ A + E + L K RH + ++ S Q+
Sbjct: 10 ERTELNKLPKSVQNK------LEKFLADQQSEIDGL------KGRHEKFKVE----SEQQ 53
Query: 1533 LSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLH 1592
+++ + Q+ L + QSLR+EL EKL+ + + L E + E QD +
Sbjct: 54 YFEIEKRLSHSQERLVNETRECQSLRLEL---EKLNNQLKALTEKNKELEIAQDRNIAIQ 110
Query: 1593 SLLM----EIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQE-----GALTLAVQAVS 1643
S E++A + L R+ E S L E + R EK +E G L L + +
Sbjct: 111 SQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQ 170
Query: 1644 IPEVPLQ--PDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGS 1701
+V ++ + + +K + S N++ ++ + GN+ L C+ +
Sbjct: 171 ASDVSVKYREKRLEQEKELLHSQNTW--LNTELKTKTDELLALGREKGNEILELKCNLEN 228
Query: 1702 SATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSS 1761
+ + G + H+ +ED LK+ + Q + E A
Sbjct: 229 KKEEVSRLEEQMNG----LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK 284
Query: 1762 TSQELGTKGPHPAPLSKFVSSVSTAKLT-LEEAYRRLKLLWRVSLPEDGQCPLHCEQIGE 1820
S L K + S AK L A L L + + + H ++ +
Sbjct: 285 LSN-----------LYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQ 333
Query: 1821 MKAEVTK-LHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQ 1859
K ++ K + +K+ EK+L+N LL +KR+ ++ ++
Sbjct: 334 SKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEE 373
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 107 bits (266), Expect = 1e-22
Identities = 314/1646 (19%), Positives = 623/1646 (37%), Gaps = 263/1646 (15%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL------ 117
E Q LKKEN +K + E + + + +++I E+E+LK EL
Sbjct: 89 EQQCLSLKKENIKMKQEV----EDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 118 --QEREQLLIKASKAVESLAEAGGS-EIQRVKEDARKKVQQ----VEDLLTKRILLLEKD 170
+++ L + +A+ + E + Q ED KK+Q+ + ++IL L+K
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQ 204
Query: 171 VTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAM-ALVLDEKDRLIEELKLS 229
+ A E ++ T+ + + + + + E L + A+ +E L+ +++ S
Sbjct: 205 LDATTDEKKETV--TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262
Query: 230 LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-----KE 284
K EA I L E K + E S ++ E + T A ++Q +
Sbjct: 263 AKEHEAEINKLNELKENLVKQCE-ASEKNIQKKYECELENLRKATSNANQDNQICSILLQ 321
Query: 285 RNSF-----EERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNS 339
N+F E+++ LE+ L+E E ++S+ +D+ + LK L
Sbjct: 322 ENTFVEQVVNEKVKHLEDTLKE------LESQHSILKDEVTYMNNLKLK--------LEM 367
Query: 340 EIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRR 399
+ + + F RE L+ + E+ + ++ A L Q +++R +
Sbjct: 368 DAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQ 427
Query: 400 SIKKITQE---------LSDLQQER-------ERLEKDLEEAHREKSKGDCTIRDLRNEV 443
S+K+ Q+ LSD ++E+ + L++ E +EK + LR +
Sbjct: 428 SLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM 487
Query: 444 EKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEV 503
E L+ E+ E + ++S+ + +H +Q ++ + +KD LL+ N E
Sbjct: 488 EILQTELGESAGKISQEFESMKQQQASDVHELQQKLR---TAFTEKDALLETVNRLQGE- 543
Query: 504 IQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI-FSKEKKQSSDYEELIQVLKKEQD 562
N L++ ++L E I + Q+ G + S+ + E I L +E+D
Sbjct: 544 ---NEKLLSQQELVPELENTIK---NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKD 597
Query: 563 IYTHLVK-SLQESDSINN-LQAELNKIFALRKQLEQDVLSYQNLRKT-------LEEQIS 613
+ + +K S +E D+ + + E I L K++EQ + L + LEE +
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK 657
Query: 614 EIRRREEE------SFSLYSDQTSYLSI----CLEENNRFQVEH----------FSQEE- 652
E + +++ + S+ LS EENN+ E SQ+E
Sbjct: 658 EKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED 717
Query: 653 --LKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGF----QGNGFPDRLASTEQTELLAS 706
LK+ ++ L + ++ + + +L K + + Q GF + S E+
Sbjct: 718 VILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS----EVSED 773
Query: 707 KEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPG 766
E++D + + LQ E + +++ C + R + K+ + +
Sbjct: 774 SEEKDVVNV-------------LQAVGESLAKINEEKCNLAFQR--DEKVLELEKEIK-- 816
Query: 767 CLEEGAFI------NLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLD 820
CL+E + + +LL EK L R +L ++ E Q L E + + E
Sbjct: 817 CLQEESVVQCEELKSLLRDYEQEKVLL----RKELEEIQSEKEALQSDLLEMKNANEKTR 872
Query: 821 GKTEKTPKQKGEL--------VHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDAS 872
+ + Q E+ +H + F K H+ LK E + ++ + LKD+
Sbjct: 873 LENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSL 932
Query: 873 VQTVATEGDLLRFKHEATREAWEEKPINTALSAEHRPENLHGV---------------PG 917
++ + + D L E EEK N + + E ++ +
Sbjct: 933 AKSPSVKNDPLSSVKEL-----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
Query: 918 WQAALLSLPGI-TNREAKKSRLPILIKPSRSLGNMY--------RLPATQEVVTQLQSQI 968
Q L + + ++ + + LI+ + S N+ +L +E + +I
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 969 LELQGELK----EFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQ 1024
+L +L+ + +T N L E + + +L Q
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ-------------- 1093
Query: 1025 KGIKTTSSVWRDKEMDSDQ-QRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLS 1083
+ DKE+++++ Q+ +I ++L L + + L T L
Sbjct: 1094 -----RAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
Query: 1084 SK-SQPSAKVSVMGTDQSESINTSNETEYLK-QKIHDLETELEGYQNFIFQLQKHSQCSE 1141
K +Q + +++ D + N+ K KI DLE E++ Q QK E
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK------IQKQKQETLQE 1202
Query: 1142 AIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE- 1200
I ++ + ++ +K K VK K L D +L+
Sbjct: 1203 EITSLQSSVQQYEEKNTKIKQ---------------LLVKTKKELADSKQAETDHLILQA 1247
Query: 1201 NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
+LK +LE + +++ + ++ SE H + + + +L Q R +LQ +
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECR 1307
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASD--VDYCVAEGFQEQLNQCAELLEKLEKLFLN 1318
++ + + ++ L Q + + EG +++ L+++L K+ L
Sbjct: 1308 AAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL-KIKLQ 1366
Query: 1319 GKSVGVEMNTQNELMERIEEDNLTYQH--LLPE--SPEPSASHALSDYETSEKSFFS-RD 1373
+++N + E D L +H +L E S E L ++ S
Sbjct: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHT 1426
Query: 1374 QKQDNETEKTSVMVNSFS---QDLLMEHIQEIRTLRKRLEE----------------SIK 1414
Q T + V+ NSF + L EH + + TL+++L + +
Sbjct: 1427 QTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVS 1486
Query: 1415 TNEKLRKQLERQGSE--FVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRD 1472
+ + L+ ER+ ++ + T G + ++ T + Q+L +L
Sbjct: 1487 SQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLL------ 1540
Query: 1473 KQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQE 1532
KL L + E L ++ +S + + L E E N L+++++ E
Sbjct: 1541 -NSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSE 1599
Query: 1533 LSRV---QEEVKLRQQLLSQNDKLLQ 1555
+ R+ QE K L + LLQ
Sbjct: 1600 IRRLERNQEREKSAANLEYLKNVLLQ 1625
Score = 101 bits (252), Expect = 6e-21
Identities = 304/1568 (19%), Positives = 606/1568 (38%), Gaps = 274/1568 (17%)
Query: 195 LESKLSEMKKMH----EGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACP 250
LE ++ E++ GD+ AL + D L+ L+ E QCL +K +
Sbjct: 51 LEKEIEELRSKPVTEGTGDIIKALT-ERLDALL------LEKAETEQQCLSLKKENIKMK 103
Query: 251 DENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEK 310
E S G + +E E + + + KE + + + A+ E + + +
Sbjct: 104 QEVEDSVTKMG-------DAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQL 156
Query: 311 KNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQK---AQTQEFQ--- 364
+ ++ + + E V++L EIEK+ F + LQK A T E +
Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216
Query: 365 ---------GSEDYETALSGKEALSAALRSQNLTKSTE-NHRLRRSIKKITQELSDLQQE 414
S+ Y+ ++ + L++ + + E ++ S K+ E++ L +
Sbjct: 217 TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNEL 276
Query: 415 RERLEKDLEEAHRE-KSKGDCTIRDLR---------NEVEKLRNEVNEREKAMENRYKSL 464
+E L K E + + + K +C + +LR N++ + + N + + N
Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336
Query: 465 LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR----- 519
L ++ K+L +Q ++K N + L E D + I+ + EDLE +
Sbjct: 337 LEDTLKELESQHSILKDEVTYMNNLKLKL----EMDAQHIKDE-FFHEREDLEFKINELL 391
Query: 520 ----SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESD 575
+G + EK S+ +K ++ + + + L + +KE S E +
Sbjct: 392 LAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKE 451
Query: 576 SIN---NLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSY 632
+ +Q + L+++ ++ +L+Y++LR+ +E +E+ ES S +
Sbjct: 452 KLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL----GESAGKISQEFES 507
Query: 633 LSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFP 692
+ +++ V +L Q ++ +T+ L +T+ L G
Sbjct: 508 M----------------KQQQASDVHELQQKLRTAFTEKDALLETVNRL-------QGEN 544
Query: 693 DRLASTEQTELLASKEDEDTIK-IGEDDEINFLSDQHLQQSNEIMKDL-----SKGGCKN 746
++L S Q EL+ E E+TIK + E + + LS L Q + ++K+L S K+
Sbjct: 545 EKLLS--QQELV--PELENTIKNLQEKNGVYLLS---LSQRDTMLKELEGKINSLTEEKD 597
Query: 747 GYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806
++ ++ + D H EE + L +K ++ +L + V EL G
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILEL-----GKKVEQTIQYNSELEQKVNELTGG- 651
Query: 807 LFLTEQEVSGEHLDGKTEKTPKQKGELVH------------FVQTNSFSKPHDELKLSCE 854
L E + D K EK Q L + + N S +L E
Sbjct: 652 --LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
Query: 855 AQLVKAGEV---PKVGLKDASVQTVATEGDLLR--FKHEATREAWEE-------KPINTA 902
L + +V + + +Q + E D L ++E ++ + + K + +
Sbjct: 710 VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSE 769
Query: 903 LSAEHRPENLHGVPGWQAALLSLPGIT--------NREAKKSRLPILIKPSRSLGNMYRL 954
+S + +++ V QA SL I R+ K L IK + ++ +
Sbjct: 770 VSEDSEEKDVVNV--LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE-ESVVQC 826
Query: 955 PATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVG 1014
+ ++ + + + L+ EL+E ++ + L L+ + E ++ LL V
Sbjct: 827 EELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVS 886
Query: 1015 AAYQDS----PGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPE 1070
S E+ IK ++ E + R E+ I D LA PS K +P
Sbjct: 887 QTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL---ILLKDSLAKSPSVKNDPL 943
Query: 1071 DVLSP-----TSVATYLSSKSQPSAKVSVMGTDQSESINTS-NETEYLKQKIHDLETE-- 1122
+ ++ K + K+ ++ + +++S ET+ +K+++ L +E
Sbjct: 944 SSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 1123 ------------LEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKN-------- 1162
E Y+N + + +K S+ + E + L++
Sbjct: 1004 QLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 1163 -GSDGEEM--TFSSLHQVRYVKHVKILG-PLAPEMIDSRV-LENL--KQQLEEQEYKLQK 1215
SD E++ +L + V+IL A M+D + E L +Q+++E + +
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
+ L +QL E LQ ++L LV+ A++ +L +I D + Q +
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQEL------ELVKKDAQQTTLMNMEIADYERLMKELNQKLT 1177
Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER 1335
E+L Q + E QE E+ + +++
Sbjct: 1178 NKNNKIEDLEQEIKIQKQKQETLQE------------------------EITSLQSSVQQ 1213
Query: 1336 IEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLL 1395
EE N + LL ++ + L+D + +E E E + V + L
Sbjct: 1214 YEEKNTKIKQLLVKTKK-----ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQL- 1267
Query: 1396 MEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSI---FASGSELHSSLTSE- 1451
EI + + ++ E +KT+ +Q +R S + Q T++ + +++TSE
Sbjct: 1268 ----AEITSEKHKIHEHLKTS---AEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF 1320
Query: 1452 ------IHFLRKQ--NQALNAMLIKGSRDKQKENDKLRESLSRK-----------TVSLE 1492
+H + KQ N++++ +G++ +++ + L + L K L+
Sbjct: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQ 1380
Query: 1493 HLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS--GQELSRVQEEVKLRQQLLSQN 1550
LQ E+ ++ E + ++ +E KE ++E CS + + E + QL SQN
Sbjct: 1381 TLQSEHDTLLERHNKMLQETVSKEAE----LREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436
Query: 1551 DKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIE 1610
+ L S R +++ L EEHR+ E L L +++A QL+
Sbjct: 1437 EVLRNSFRDQVR---HLQEEHRKTVET-------------LQQQLSKMEAQLFQLKNEPT 1480
Query: 1611 TSSTLQSR 1618
T S + S+
Sbjct: 1481 TRSPVSSQ 1488
Score = 98.2 bits (243), Expect = 7e-20
Identities = 276/1377 (20%), Positives = 553/1377 (40%), Gaps = 196/1377 (14%)
Query: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR 384
M ++ + + EL EIE+L + K T+ G+ D AL+ E L A L
Sbjct: 39 MLIQKAKSRCTELEKEIEELRS----------KPVTE---GTGDIIKALT--ERLDALLL 83
Query: 385 SQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE 444
+ T+ + L++ K+ QE+ D + K+LE++H K I +L+NE+
Sbjct: 84 EKAETEQ-QCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK---EIENLKNELM 139
Query: 445 KLRNEVNEREKAMENRYKSL------LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNE 498
+R++ +E + ++ + + LSE K +N E +K L E + ++ E
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEK----IRPGFE 195
Query: 499 KDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLK 558
+ + +Q+ E E ++ + +SQ +K +S EEL+Q+
Sbjct: 196 EQILYLQKQLDATTDEKKETVTQLQNIIEANSQH---------YQKNINSLQEELLQLKA 246
Query: 559 KEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQL-EQDVLSYQNLRKTLEEQISEIRR 617
Q+ L+ ++ S + +AE+NK+ L++ L +Q S +N++K E ++ +R+
Sbjct: 247 IHQEEVKELMCQIEASAKEH--EAEINKLNELKENLVKQCEASEKNIQKKYECELENLRK 304
Query: 618 REEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKT 677
+ + SI L+EN F ++ + +KV L +KEL + + LK
Sbjct: 305 ATSNA----NQDNQICSILLQENT------FVEQVVNEKVKHLEDTLKELESQHSILKDE 354
Query: 678 I---------FDLSCMGFQGNGFPDRL-ASTEQTELLASKEDEDTIKIGEDDEINFLSDQ 727
+ ++ + F +R + ELL +KE++ + E+ L+ Q
Sbjct: 355 VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414
Query: 728 H---LQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEK 784
++Q N ++ L + K E+ +SD + E L EK
Sbjct: 415 FCYTVEQHNREVQSLKEQHQKE-ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEK 473
Query: 785 ATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVH--------- 835
+L + L+ + E+L +L + ++S E E +Q+ VH
Sbjct: 474 QEAILNY--ESLREIMEILQTELGESAGKISQEF-----ESMKQQQASDVHELQQKLRTA 526
Query: 836 FVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQ--------TVATEGDLLRFKH 887
F + ++ + + L+ E L + VP++ ++Q +++ +L+
Sbjct: 527 FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELE 586
Query: 888 EATREAWEEKP--INTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPS 945
EEK IN ++ +N H ++ ++ IL
Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH-----------------KKCEREERLIL---- 625
Query: 946 RSLGNMYRLPATQEVVTQLQSQILELQGELKEF---KTCNKQLHQKLILAEAVMEGRPTP 1002
LG ++ T + ++L+ ++ EL G L+E K N Q +KL++ V+ +
Sbjct: 626 -ELGK--KVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVL----SE 678
Query: 1003 DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASL 1062
DK +L+A+ V + Y+++ K S RD E+ Q+ + I + L
Sbjct: 679 DKEVLSAE--VKSLYEENNKLSSEKKQLS---RDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 1063 PSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETE 1122
+++ + L L K+Q + MG++ SE + L+ L
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793
Query: 1123 LEGYQNFIFQ-------LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLH 1175
E N FQ L+K +C + V C ++ S ++ + + L
Sbjct: 794 NEEKCNLAFQRDEKVLELEKEIKCLQEESVVQC-----EELKSLLRDYEQEKVLLRKELE 848
Query: 1176 QVRYVKHVKILGPLAPEMIDSRVLE----NLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
+++ K E + S +LE N K +LE Q +Q E+ SEIHN +
Sbjct: 849 EIQSEK----------EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEK 898
Query: 1232 NK-----FRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
K +L P L Q + R+ + +KD + + +K EE ++
Sbjct: 899 EKCFIKEHENLKP----LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954
Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHL 1346
+ +C E EK+ K+ L E+++ + + ++E+ + L
Sbjct: 955 NLE-------------KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEE---LESL 998
Query: 1347 LPESPEPSAS-HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTL 1405
E + SAS L S K+ +KQ + + N+F + + + +++R
Sbjct: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNF-EHRIEDLTRQLRNS 1057
Query: 1406 RKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAM 1465
+ E NE L ++E S I + + E+ + Q +
Sbjct: 1058 TLQCETINSDNEDLLARIETLQSNAKLLEVQILEV-QRAKAMVDKELEAEKLQKE----Q 1112
Query: 1466 LIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENER---LQKEGSEKERHNQQL 1522
IK E ++L+ L ++ L+ +E VK++ ++ + E ++ ER ++L
Sbjct: 1113 KIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 1523 IQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRL-----REA 1577
Q++ ++ +++E+K+++Q + + SL+ ++ YE+ + + ++L +E
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1232
Query: 1578 SGEGWKGQDPFRDLHSLLMEIQALRLQLE---RSIETSSTLQSRLKEQLARGAEKAQ 1631
+ D SL E++A + Q+E + ++ + ++ E L AE+ Q
Sbjct: 1233 ADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQ 1289
Score = 83.6 bits (205), Expect = 2e-15
Identities = 297/1476 (20%), Positives = 562/1476 (38%), Gaps = 230/1476 (15%)
Query: 60 MKDFENQITELKKENF---NLKLRIYFLEERMQQEFHGPTEHI-YKTNIELKVE------ 109
+K+ E+Q + LK E NLKL++ + ++ EF E + +K N L +
Sbjct: 341 LKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400
Query: 110 VESLKRELQEREQLLI----KASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRIL 165
+E LK EL + + ++ V+SL E EI + E ++ + L I
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM--KKMHEGDLAMALVLDEKDRLI 223
L++ Q E ++A E+ + + L+++L E K E + + L
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 224 EELKLSLKSKEALIQC---LKEEKSQMACPDENVSSGE-----------LRGLCAAPREE 269
++L+ + K+AL++ L+ E ++ E V E + L + R+
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580
Query: 270 KERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKS 329
+E E +E++ F +++ E++ ++ E++ L+ K ++
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 330 KEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT 389
E+KV EL +E+ + + L+K Q SED KE LSA
Sbjct: 641 LEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED-------KEVLSA-------- 685
Query: 390 KSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK---- 445
+K + +E + L E+++L +DLE +K D +++ ++EK
Sbjct: 686 ----------EVKSLYEENNKLSSEKKQLSRDLEVFLSQKE--DVILKEHITQLEKKLQL 733
Query: 446 LRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDV--LLQKFNEKDLEV 503
+ E + K +EN L + +++ ++E + +KDV +LQ E ++
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKI 793
Query: 504 IQQNCYLMAAED---LELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560
++ C L D LEL E KC ++ S + K DYE+ +L+KE
Sbjct: 794 NEEKCNLAFQRDEKVLELEKE----IKCLQEE---SVVQCEELKSLLRDYEQEKVLLRKE 846
Query: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEE-----QISEI 615
L+E S +A + + ++ E+ L QNL +EE SEI
Sbjct: 847 ----------LEEIQS--EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEI 894
Query: 616 RRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVS---DLIQLVKELYTDNQ 672
+E+ F + L E +R ++ L K S D + VKEL +
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIE 954
Query: 673 HLKKTIFDLSCMGFQGNGFPDRLASTE-QTELLASKEDEDTIKIGEDDEINFLSDQHLQQ 731
+L+K C + +L + + + EL +S+++ T+K +E+ L + Q
Sbjct: 955 NLEK-----ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVK----EELESLRSEK-DQ 1004
Query: 732 SNEIMKDLSKG--GCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNE--KATL 787
+ M+DL +G KN L + E + D E +L L N +
Sbjct: 1005 LSASMRDLIQGAESYKNLLLEY-EKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 788 LLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHD 847
+ DLL + L L Q + + +K + + K
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAE-------------KLQK 1110
Query: 848 ELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPINTALSAEH 907
E K+ A V E +V L+ Q T +L K +A + T ++ E
Sbjct: 1111 EQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQ--------TTLMNME- 1161
Query: 908 RPENLHGVPGWQAALLSL-PGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQS 966
+ ++ + L +TN+ K L IK + + QE +T LQS
Sbjct: 1162 -------IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ-----KQETLQEEITSLQS 1209
Query: 967 QILELQGELKEFKTC----------NKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAA 1016
+ + + + + K +KQ ++ +A ++G + + A
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
Query: 1017 YQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPT 1076
+ TS+ + + + QQR + E C+ + + T
Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE------------CRAAKAEQATVT 1317
Query: 1077 S------VATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQN-- 1128
S V + K Q + +S Q+E+ E E+L+ I L+ +L+ QN
Sbjct: 1318 SEFESYKVRVHNVLKQQKNKSMS-----QAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 1129 --FIFQLQ----KHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKH 1182
+ +LQ +H E +L T + L + E M S +H
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKS-------EH 1425
Query: 1183 VKILGPLAP--EMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPP 1240
+ + L E++ + + ++ EE ++ Q ++ +++ L+N+ P
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE------P 1479
Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQE 1300
S V SQ +L+ ++ D + M+T+ + E ++ +D E
Sbjct: 1480 TTRSPVSSQQSLKNLRERRNTD------LPLLDMHTVTREEGEGMETTDT---------E 1524
Query: 1301 QLNQCAELLEKLEKLFLNGKSVGVEMN------TQNELMERIEEDNLTYQHLLPESPEPS 1354
++ + + LE+L LN +E T+ EL++++ + HL E
Sbjct: 1525 SVSSASTYTQSLEQL-LNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETE 1583
Query: 1355 ASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIK 1414
A++A+ + R +++ E EK++ + LL + + R+RL I
Sbjct: 1584 ATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVIN 1643
Query: 1415 TNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450
T +L S +G + A G E ++S +S
Sbjct: 1644 TMLQL--------SPEEKGKLAAVAQGEEENASRSS 1671
Score = 65.9 bits (159), Expect = 4e-10
Identities = 116/573 (20%), Positives = 233/573 (40%), Gaps = 94/573 (16%)
Query: 55 TRARNMKDFENQITELK--KENFNLKLRIYFLEERMQQEFHGPT-EHIYKTNIELKVEVE 111
T N K E QI E++ K + +L L++ + + H T + + ++L+ E +
Sbjct: 1077 TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKK 1136
Query: 112 SLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKV----QQVEDL------LT 161
L++ +QE E L+K +L ++ +R+ ++ +K+ ++EDL
Sbjct: 1137 QLQKTMQELE--LVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 162 KRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDR 221
++ L++++T+ Q+ +++ K L ++ + +L++ K+ E D
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA------------ETDH 1242
Query: 222 LIEELKLSLKSK-EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQME 280
LI L+ SLK + EA Q ++ K Q+A + + + + + +
Sbjct: 1243 LI--LQASLKGELEASQQQVEVYKIQLA-------------EITSEKHKIHEHLKTSAEQ 1287
Query: 281 HQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSK---EKKVEEL 337
HQ+ +++++R+ AL+E+ R + E AT + + K+K + + E
Sbjct: 1288 HQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA 1347
Query: 338 NSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRL 397
E E L + + LQ +Q + +T S + L L
Sbjct: 1348 KQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL-----------------L 1390
Query: 398 RRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAM 457
R K + + +S + RE+L E KS+ T+ L ++ E LRN ++ + +
Sbjct: 1391 ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450
Query: 458 ENRYKSLLSESNKKLHNQE-QVIKHLTESTNQKDVL-------LQKFNEKDLEVIQQNCY 509
+ ++ + ++L E Q+ + E T + V L++ DL ++ +
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 510 L------MAAEDLELRS---------EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
M D E S E L+ + +PP F+K EEL+
Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK--------EELV 1562
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKI 587
Q L HL L+E+++ N + E K+
Sbjct: 1563 QKLSSTTKSADHLNGLLRETEATNAILMEQIKL 1595
Score = 54.7 bits (130), Expect = 8e-07
Identities = 255/1281 (19%), Positives = 494/1281 (38%), Gaps = 238/1281 (18%)
Query: 443 VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLE 502
++K ++ E EK +E ++E +IK LTE + +LL+K
Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVTEGTG------DIIKALTERLDA--LLLEKAET---- 88
Query: 503 VIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYE----ELIQVLK 558
+Q C + E+++++ E E ++ K + + E EL+ V
Sbjct: 89 --EQQCLSLKKENIKMKQE---VEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRS 143
Query: 559 KEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRR 618
K + +L K L+E+ N Q EL++ + E +V K L+E+I +IR
Sbjct: 144 KYSEDKANLQKQLEEA---MNTQLELSEQLKFQNNSEDNV-------KKLQEEIEKIRPG 193
Query: 619 EEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
EE Q YL L+ +E K+ V+ L +++ ++QH +K I
Sbjct: 194 FEE-------QILYLQKQLDATT---------DEKKETVTQLQNIIE---ANSQHYQKNI 234
Query: 679 FDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKD 738
L Q ++ AS ++ + E +++N L + ++Q K+
Sbjct: 235 NSLQEELLQLKAIHQEEVKELMCQIEASAKEHEA----EINKLNELKENLVKQCEASEKN 290
Query: 739 LSKG-GCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLL------LES 791
+ K C+ LR S + D L+E F+ + NEK L LES
Sbjct: 291 IQKKYECELENLRKATSNANQ-DNQICSILLQENTFVEQVV---NEKVKHLEDTLKELES 346
Query: 792 RPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKL 851
+ +LK E+ + E+ +H+ K E H + F +EL L
Sbjct: 347 QHSILK--DEVTYMNNLKLKLEMDAQHI----------KDEFFHEREDLEFKI--NELLL 392
Query: 852 SCEAQ--LVKAGEVPKVGLKDASVQTVATEG-DLLRFKHEATREAWEEKPINTALSAEHR 908
+ E Q +++ + GL TV ++ K + +E E + S + +
Sbjct: 393 AKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEK 452
Query: 909 PENLHGVPGWQAALLSLP-----GITNREAKKSRLPIL-IKPSRSLGNMYRLPATQEVVT 962
+ + G + +L I N E+ + + IL + S G + + + +
Sbjct: 453 LTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQ--EFESMKQ 510
Query: 963 QLQSQILELQGELKEFKTCNKQL----------HQKLILAEAVMEGRPTPDKTLLNAQPP 1012
Q S + ELQ +L+ T L ++KL+ + ++ P + T+ N Q
Sbjct: 511 QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV---PELENTIKNLQ-- 565
Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDV 1072
E+ G+ S RD + + + + E DD + K + E++
Sbjct: 566 ----------EKNGVYLLSLSQRDTMLKELEGKINSLTEE---KDDFIN--KLKNSHEEM 610
Query: 1073 LSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDL-----ETELEGYQ 1127
+ + + +G ++I ++E L+QK+++L ET E Q
Sbjct: 611 ------DNFHKKCEREERLILELGKKVEQTIQYNSE---LEQKVNELTGGLEETLKEKDQ 661
Query: 1128 N------FIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE-EMTFSSLHQVRYV 1180
N + Q++ S+ E + + + LS K + E+ S V
Sbjct: 662 NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 1181 KHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPP 1240
+H+ L M++ + +NL + LE ++ + + + QL+ + + ++ +
Sbjct: 722 EHITQLEKKLQLMVEEQ--DNLNKLLENEQVQ---KLFVKTQLYGFLKEMGSEVSE---- 772
Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQE 1300
S+ +++ Q + G + I+ + N + E++L+ C+ E E
Sbjct: 773 ------DSEEKDVVNVLQAV--GESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE---E 821
Query: 1301 QLNQCAELLEKL-----EKLFLNGKSVGVEMNT---QNELMERI---EEDNLTYQHLLPE 1349
+ QC EL L EK+ L + ++ Q++L+E E+ L Q+LL +
Sbjct: 822 SVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQ 881
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRL 1409
E S + + S+ NE EK I+E L+ L
Sbjct: 882 VEEVSQTCSKSEIH--------------NEKEKC--------------FIKEHENLKPLL 913
Query: 1410 EESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKG 1469
E+ K+L + +E + S+ S S + L+S K+ + L K
Sbjct: 914 EQ---------KELRDRRAELILLKDSLAKSPSVKNDPLSSV-----KELEEKIENLEKE 959
Query: 1470 SRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
++K+++ +K++ + L+ ++E +VKEE E L+ E + + LIQ
Sbjct: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ----- 1014
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKA----YEKLDEEHRRLREASGE----G 1581
G E + LL + +K + L VE + ++++ R+LR ++ +
Sbjct: 1015 GAESYK---------NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETIN 1065
Query: 1582 WKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQA 1641
+D + +L + L +Q+ + + L+ + + +K +E A T V
Sbjct: 1066 SDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATT--VNE 1123
Query: 1642 VSIPEVPLQPDKHDGDKYPME 1662
+ +V LQ +K K E
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQE 1144
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 106 bits (264), Expect = 2e-22
Identities = 298/1438 (20%), Positives = 573/1438 (39%), Gaps = 239/1438 (16%)
Query: 206 HEGDLAMALVLDEKDRL---IEELKLSLKSKEALIQCLKEE-------KSQMACPDENV- 254
H G+ +AL D+ L +++L+ SLK ++ + LK+E + Q A PD V
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131
Query: 255 -SSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEK--- 310
SS EL+ L E++ E AQ E+ I+ +++ +K ++ATE
Sbjct: 132 DSSAELQSL--------EQQLEEAQTENFN--------IKQMKDLFEQKAAQLATEIADI 175
Query: 311 KNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYE 370
K+ +++++ ++ E+KV L E+ K + +Q +T+ Q +
Sbjct: 176 KSKYDEERSLR------EAAEQKVTRLTEELNKEATV-------IQDLKTELLQRPGIED 222
Query: 371 TALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKS 430
A+ KE + N+T E R +K+ E LQ + E + + E +
Sbjct: 223 VAVLKKELVQVQTLMDNMTLERE-----RESEKLKDECKKLQSQYASSEATISQLRSELA 277
Query: 431 KGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKD 490
KG + E++KL++ VNE + + ++LL + +E KH ES ++K+
Sbjct: 278 KGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE---KHNEESVSKKN 334
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
+ ++KDL+ Q L A+E R ++EK + Q K K++ S+
Sbjct: 335 I-QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQ---------KLKEELSEV 384
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSIN-NLQAELN----KIFALRKQL--------EQD 597
E Q LK E + L + +E + LQ+E+N K+ +QL EQ
Sbjct: 385 ETKYQHLKAE---FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441
Query: 598 VLSYQNLRKTLEEQISEIR----RREEESFSLYSDQTSYLSICLEENNRFQVEHFSQE-- 651
LS + L E+Q+++++ R EE+ ++ T + + Q + Q+
Sbjct: 442 QLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
Query: 652 --ELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKE- 708
+L++ +DL Q+++++ +Q ++ +L + Q + L E+ +L A +
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQ----NLEAL-LQKSKENISLLEKEREDLYAKIQA 555
Query: 709 -DEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS---KGGCKNGYLRHTESKISDCDGAHA 764
+ +T + + E N + + Q E +K+ S K +N + + E K AH
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK------AHL 609
Query: 765 PGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTE 824
+ + L NE + L ES+ + QL + + + L +
Sbjct: 610 RAAQDR---VLSLETSVNELNSQLNESKEK---------VSQLDIQIKAKTELLLSAEAA 657
Query: 825 KTPKQKGELVHFVQT--NSFSKPHDEL-KLSCEAQLVKAGEVPKVGLKDASVQTVATEGD 881
KT Q+ +L + + T N+ EL K++ + V A L+D E
Sbjct: 658 KT-AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA------KLQDKQEHCSQLESH 710
Query: 882 LLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPIL 941
L +K + LS E + E L G Q L + + +K+ L L
Sbjct: 711 LKEYKEK-------------YLSLEQKTEELEG----QIKKLEADSLEVKASKEQALQDL 753
Query: 942 IKPSRSLGNMYRLPATQ---------EVVTQLQSQILELQGELKEFK-TCNKQLHQKLIL 991
+ R L L AT+ E+V+ + + + L+ K KQ +K IL
Sbjct: 754 -QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 992 A---EAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDK-EMDSDQQRSY 1047
E + + + L N Q E++ + T S +DK SD ++
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 1048 EIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSN 1107
+ + E A++ ++ +++ V + K Q K S+
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL------------- 919
Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167
E K+ H L+ EL Q + Q Q + +E + Q +++ K S+ +
Sbjct: 920 --EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK------EEQQLQGNINELKQSSEQK 971
Query: 1168 EMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLEN-LKQQLEEQEYKLQKEQNLNMQLFSE 1226
+ +L G L ++ LEN L+QQL + +L E+ L +
Sbjct: 972 KKQIEALQ-----------GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1227 IHNLQNKFRDLSPPRY--DSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEEL 1284
Q F+ L Y +S + + ++L +++ + +R + K +EL
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 1285 LQA-SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTY 1343
A + ++ A+ Q+ +C L + ++ L K + +N +++L E IEE
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL---VNEKSKLAE-IEEIKCRQ 1136
Query: 1344 QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIR 1403
+ + + E SH L E+ ++ +D KQ +K + + S +E
Sbjct: 1137 EKEITKLNEELKSHKL---ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ----- 1188
Query: 1404 TLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALN 1463
KR ++ +K ++++K+ E EF++ ++LHS +
Sbjct: 1189 --EKRNQQILK--DQVKKEEEELKKEFIE-------KEAKLHSEI--------------- 1222
Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLI 1523
++K+ K E+ ++ T+ + L +VK+E + Q+ SE E+ L
Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 1524 QEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVE-LKAYEKLDEEHRRLREASGE 1580
E+ + Q+E + + + + ++ L+ + L+ KLD ++E E
Sbjct: 1276 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
Score = 92.0 bits (227), Expect = 5e-18
Identities = 287/1346 (21%), Positives = 525/1346 (39%), Gaps = 228/1346 (16%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE 119
++ E Q+ E + ENFN+K E++ Q L E+ +K + E
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ---------------LATEIADIKSKYDE 181
Query: 120 REQLLIKASKAVESLAEAGGSE---IQRVKED------------ARKKVQQVEDLLTKRI 164
L A + V L E E IQ +K + +K++ QV+ L+
Sbjct: 182 ERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241
Query: 165 LLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIE 224
L E++ + E +K + + +A +L S+L+ +G +A+ + E +L
Sbjct: 242 LERERESEKLKDECKKLQSQYASSEATISQLRSELA------KGPQEVAVYVQELQKLKS 295
Query: 225 EL-KLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQK 283
+ +L+ K++ LK+E+ +++ + A +K+ + + Q
Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355
Query: 284 ERNSFEERIQALEE--DLREKEREIATEKKNSLKRDKA-IQGLTMALKSKEKKVEELNSE 340
S L E + +K +E +E + + KA + L + KE+ +L SE
Sbjct: 356 SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415
Query: 341 IEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR----------SQNLTK 390
I +L + + L +A + + + L KE A L+ + +T
Sbjct: 416 INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475
Query: 391 STENHRLRRSIKKITQELSDLQQ----ERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446
STE K+ QE LQQ + + DLE+ R+ D I++L ++K
Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535
Query: 447 RNEVNEREKAMENRY---------KSLLSESNKKLHNQEQVIKHLTES-TNQKDVLLQKF 496
+ ++ EK E+ Y ++L++ +K H ++ + LTE NQ + Q
Sbjct: 536 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595
Query: 497 NEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQV 556
+V +Q +L AA+D L E + E S+ SKEK D IQ+
Sbjct: 596 ENLHDQVQEQKAHLRAAQDRVLSLETSVNEL-------NSQLNESKEKVSQLD----IQI 644
Query: 557 -LKKEQDIYTHLVKSLQESDSINNL----------QAELNKIFALRKQLEQDVLSYQNLR 605
K E + K+ Q +D N+L Q ELNKI QL+Q Q+ +
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI---TTQLDQVTAKLQDKQ 701
Query: 606 KTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK 665
+ + S ++ +E+ SL +T L + + + + + K++ +Q +
Sbjct: 702 EHCSQLESHLKEYKEKYLSL-EQKTEELE---GQIKKLEADSLEVKASKEQALQDLQQQR 757
Query: 666 ELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTI--KIGEDDEINF 723
+L TD L+ +LS + + S+ + +L E ++I K+ + +E
Sbjct: 758 QLNTD---LELRATELS----KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--- 807
Query: 724 LSDQHLQQSNEIMKDLSKGGCKNGYLRHTE--SKISDCDGAHAPGCLEEGAFINLLAPLF 781
Q L+Q E + +K ++H E ++I + L +
Sbjct: 808 -EKQILKQDFETLSQETK-------IQHEELNNRIQ--------------TTVTELQKVK 845
Query: 782 NEKATLL--LESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKT-----EKTPKQKGELV 834
EK L+ L + D L V + L ++ E E+ GK EKT K EL
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKN----SKSEFEKENQKGKAAILDLEKTCK---ELK 898
Query: 835 H--FVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE 892
H VQ + K ELK S E + +A K+ L Q + + L K E
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKE-KEASHQLKLELNSMQEQLIQAQNTL---KQNEKEE 954
Query: 893 AWEEKPIN-TALSAEHRPENLHGVPG-WQAALLSLPGITNR------------EAKKSRL 938
+ IN S+E + + + + G + A+L + N+ A+K ++
Sbjct: 955 QQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI 1014
Query: 939 PILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILA-EAVME 997
+ L N Y +QE QLQS + EL + K + +KL LA E ++
Sbjct: 1015 SV-------LQNNYE--KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 998 GR---PTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRD---------KEMDSDQQR 1045
R +K + + QDS +++ ++ +D KE+ +++ +
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125
Query: 1046 SYEIDSEICPPD-DLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESIN 1104
EI+ C + ++ L +E L T L Q + + +++S+
Sbjct: 1126 LAEIEEIKCRQEKEITKLN--EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183
Query: 1105 TSNETE-----YLKQKIHDLETELEGYQNFIFQLQK-HSQCSEAIITVLCGTEGAQDGLS 1158
+ E E LK ++ E EL+ + FI + K HS+ E + G+
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELK--KEFIEKEAKLHSEIKEKEV-----------GMK 1230
Query: 1159 KPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQN 1218
K + M ++L++ LG + E S + +LE+Q L+ E
Sbjct: 1231 KHEENEAKLTMQITALNE--------NLGTVKKEWQSS---QRRVSELEKQTDDLRGEIA 1279
Query: 1219 LNMQLFSEIHNLQNKFRDLSP---PRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
+ L + + N Q++ R L + + Q + L LQR+ + + R++ +
Sbjct: 1280 V---LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336
Query: 1276 TMIKAFEEL----LQASDVDYCVAEG 1297
IK + L + ++V C+A G
Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCMACG 1362
Score = 76.6 bits (187), Expect = 2e-13
Identities = 150/735 (20%), Positives = 315/735 (42%), Gaps = 93/735 (12%)
Query: 48 SEETVSPTR---ARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK--- 101
SE T+S R A+ ++ + EL+K LK + L ++ Q TE++ K
Sbjct: 265 SEATISQLRSELAKGPQEVAVYVQELQK----LKSSVNELTQKNQTL----TENLLKKEQ 316
Query: 102 --TNIELKVEVESL-KRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVED 158
T +E K ES+ K+ +Q + ++S A + + R+ + +K + +
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 159 LLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE 218
L + + +E +AE ++ E ++ L+L+S+++++ L E
Sbjct: 377 L-KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK----------LLE 425
Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
+R + E LK + L ++ ++ V+ +L+ L + KE+ T + +
Sbjct: 426 TERQLGEAHGRLKEQRQL------SSEKLMDKEQQVADLQLK-LSRLEEQLKEKVTNSTE 478
Query: 279 MEHQKERNSFE-ERIQALEEDLREKEREIATEKKNSLK----RDKAIQGLTMAL-KSKE- 331
++HQ ++ + + QAL++ K RE + + L+ +D+ IQ L L KSKE
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Query: 332 -----KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386
K+ E+L ++I+ A + +K T + Q ++ E + E+ A +
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA--QE 596
Query: 387 NLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIR--------- 437
NL + + ++ + L+ L L E+ + S+ D I+
Sbjct: 597 NLHDQVQEQKAH--LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 438 ---------DLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQ 488
DL+N ++ +N + ++++ + N+ + L + KL +++ E +Q
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQEL-NKITTQLDQVTAKLQDKQ-------EHCSQ 706
Query: 489 KDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSS 548
+ L+++ EK L ++Q + + +L ++ L K S +Q + ++++ ++
Sbjct: 707 LESHLKEYKEKYLS-LEQKTEELEGQIKKLEADSL-EVKASKEQ---ALQDLQQQRQLNT 761
Query: 549 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
D E L K+ ++ +V S + +LQ + + +++++L + Q L++
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTR-----LDLQKKSEALESIKQKLTKQEEEKQILKQDF 816
Query: 609 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVK-EL 667
E E + + EE + + L E E + ++ KVSD ++ K E
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF 876
Query: 668 YTDNQHLKKTIFDL--SCMGFQGNGFPDRLAST--EQTELLASKEDEDTIKIGEDDEINF 723
+NQ K I DL +C + + ++ +T EQ EL S E E E+N
Sbjct: 877 EKENQKGKAAILDLEKTCKELK-HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 724 LSDQHLQQSNEIMKD 738
+ +Q +Q N + ++
Sbjct: 936 MQEQLIQAQNTLKQN 950
Score = 76.3 bits (186), Expect = 3e-13
Identities = 145/759 (19%), Positives = 330/759 (43%), Gaps = 118/759 (15%)
Query: 59 NMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ 118
++ + +Q+ E K++ L ++I E + T +L+ +++ + LQ
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ----RADLQNHLDTAQNALQ 677
Query: 119 EREQLLIKASKAVESLA------EAGGSEIQRVKEDARKK---VQQVEDLLTKRILLLEK 169
+++Q L K + ++ + + S+++ ++ ++K ++Q + L +I LE
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 170 DVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLS 229
D +A E+A + ++ L LE + +E+ K L+ + ++ +L
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ----------LEMEKEIVSSTRLD 787
Query: 230 LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFE 289
L+ K ++ +K++ ++ + + +++ E ++ +++H++ N +
Sbjct: 788 LQKKSEALESIKQKLTKQEEEKQIL------------KQDFETLSQETKIQHEELNNRIQ 835
Query: 290 ERIQALEEDLREKE---REIATEK------KNSLKR-----DKAIQGLTMALKSKEKKVE 335
+ L++ EKE E++T K +SLK +K Q A+ EK +
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 336 ELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKST--E 393
EL +++ K ++ L+K+ +E + S + L+ + +++QN K E
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ--EQLIQAQNTLKQNEKE 953
Query: 394 NHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTI--------RDLRNEVEK 445
+L+ +I ++ Q +++ E L+ +L+ A +K++ + + ++L E EK
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 446 LRNEVNEREKAMENRYKSLLSE---SNKKLHNQEQVIKHLTE--STNQKDVLLQKFNEKD 500
+ N EK+ E +K L S+ +L Q +K + E S Q+D++ + +
Sbjct: 1014 ISVLQNNYEKSQET-FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Query: 501 LEVIQQNCYLMAA--EDLELRSEGLITEKCSS-QQPPGSKTIFSK----EKKQSSDYEEL 553
+ Q A E + E + E+C + Q K++ K EK + ++ EE+
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132
Query: 554 -----IQVLKKEQDIYTHLVKSLQESDSINNLQAEL--------NKIFALRKQLEQDVLS 600
++ K +++ +H ++S++E ++ + + L K +L+ +EQ+ +
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 601 YQNLRKTLEEQISEIR--------------RREEESFSLYSDQTSYLSI---CLEEN--- 640
Q L+ ++++ E++ + +E + + + L++ L EN
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 641 --NRFQVEHFSQEELKKKVSDL---IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL 695
+Q EL+K+ DL I +++ +NQ ++ + + C+ +G G ++L
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE-RCL--KGEGEIEKL 1309
Query: 696 ASTEQTELLASKEDEDTIKIGE-DDEINFLSDQHLQQSN 733
T+ E L K D T + E E L +H Q N
Sbjct: 1310 -QTKVLE-LQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346
Score = 71.2 bits (173), Expect = 9e-12
Identities = 135/713 (18%), Positives = 292/713 (40%), Gaps = 71/713 (9%)
Query: 1202 LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIK 1261
L+Q++++ + L++E+ + +L E+ Q + + P D LV + EL QQ++
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKP--DGLVTDSSAELQSLEQQLE 145
Query: 1262 DGHGICVISRQHMNTMIKAFEELLQAS---------------DVDYCVAEGFQ------- 1299
+ Q N IK ++L + D + + E +
Sbjct: 146 EA--------QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 1300 EQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELME-RIEEDNLTYQHLLP-ESPEPSASH 1357
E+LN+ A +++ L+ L + + EL++ + DN+T + E +
Sbjct: 198 EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257
Query: 1358 ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNE 1417
S Y +SE + + ++ +V V + L + E+ + L E++ E
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQK--LKSSVNELTQKNQTLTENLLKKE 315
Query: 1418 KLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKEN 1477
+ +LE + +E +I A+ + L +L+ + ++ S +K +
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS-EKGEAT 374
Query: 1478 DKLRESLSRKTVSLEHLQREYASVKEENERLQKEG----SEKERHNQQLIQEVRCSGQEL 1533
KL+E LS +HL+ E+ ++++ E ++ G SE + + +L++ R G+
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434
Query: 1534 SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHS 1593
R++E+ +L + L ++ + L+++L +L+E+ + S E D + H
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKL---SRLEEQLKEKVTNSTELQHQLDKTKQQH- 490
Query: 1594 LLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKAQ--EGALTLAVQAVSIPEVPLQP 1651
E QAL+ + + ++ Q+ +K Q E L + + +S+ L+
Sbjct: 491 --QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL----LEK 544
Query: 1652 DKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSR 1711
++ D + + + Q + L T+ L S S + +
Sbjct: 545 EREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL----TEKLKNQSESHKQAQENLHD 600
Query: 1712 LVTGH--HLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTK 1769
V HL A+++ VL L L Q+++ + ++++DIQ + + T L +
Sbjct: 601 QVQEQKAHLRAAQD--RVLSLETSVNELNSQLNESKEKVSQLDIQIK---AKTELLLSAE 655
Query: 1770 GPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWR-----VSLPEDGQCPLHCEQIGEMKAE 1824
A + + + TA+ L++ + L + + +D Q HC Q+ E
Sbjct: 656 AAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ--EHCSQLESHLKE 713
Query: 1825 VTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTHKILRKARGNLELR 1877
+ + L ++ ++L+ +K L+ + K +Q + + R+ +LELR
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
Score = 62.4 bits (150), Expect = 4e-09
Identities = 209/1108 (18%), Positives = 437/1108 (39%), Gaps = 123/1108 (11%)
Query: 575 DSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLS 634
D + L+ E+ L+ L+++ + L+K LE+ ++++E + L +D ++ L
Sbjct: 83 DDVTLLRQEVQD---LQASLKEEKWYSEELKKELEKY-QGLQQQEAKPDGLVTDSSAELQ 138
Query: 635 ICLEENNRFQVEHFSQEELK----KKVSDL---IQLVKELYTDNQHLKKTIFDLSCMGFQ 687
++ Q E+F+ +++K +K + L I +K Y + + L++ +
Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE 198
Query: 688 GNGFPDRLASTEQTELLASKEDEDTIKIGED-DEINFLSDQHLQQSNEIMKDLSKGGCKN 746
+ +TELL ED + ++ ++ L D ++ E + K CK
Sbjct: 199 ELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERESEKLKDECKK 257
Query: 747 GYLRH--TESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRP---DLLKVVRE 801
++ +E+ IS A G E ++ L L + L +++ +LLK ++
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
Query: 802 LLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTN--SFSKPHDELKLSCEAQLVK 859
+ E+ VS +++ + +L + + S + H EL EA
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL 377
Query: 860 AGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWE-EKPINTA----LSAEHRPENLHG 914
E+ +V K ++ A L + + E + + + IN L E + HG
Sbjct: 378 KEELSEVETKYQHLK--AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHG 435
Query: 915 VPGWQAALLSLP------GITNREAKKSRLPILIKP--SRSLGNMYRLPATQEVVTQLQS 966
Q L S + + + K SRL +K + S ++L T++ + Q+
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 967 -------QILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQD 1019
++ E Q +L++ QK+ EA+++ L + + A Q
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 1020 SPGE--------QKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
GE +K V + E +Q S++ E + +
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 1072 VLS-PTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIH-DLETELEGYQNF 1129
VLS TSV S ++ KVS + E K DL+ L+ QN
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 1130 IFQLQKH-SQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGP 1188
+ Q+ ++ + + V + Q+ S+ ++ + + SL Q K ++ G
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ----KTEELEGQ 731
Query: 1189 LAPEMIDSRVLENLKQQ-LEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQ 1247
+ DS ++ K+Q L++ + + Q +L ++ L+ + +S R D +
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 1248 SQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAE 1307
S+A E S++++ K + + + FE L Q + + + +E N+
Sbjct: 792 SEALE-SIKQKLTKQ--------EEEKQILKQDFETLSQETKIQH------EELNNRIQT 836
Query: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEK 1367
+ +L+K+ + +++ E++T + + ++ SD + K
Sbjct: 837 TVTELQKVKMEKEALMTELSTVKDKLSKV-----------------------SDSLKNSK 873
Query: 1368 SFFSRDQKQDN----ETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQL 1423
S F ++ ++ + EKT + Q + ++E + L+K LE+ + + +L+ +L
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933
Query: 1424 ERQGSEFVQGSTSIFASGSELHSSLTSEIHFLR-------KQNQALNAMLIKGSRDKQKE 1476
+ +Q ++ + E L I+ L+ KQ +AL L K +
Sbjct: 934 NSMQEQLIQAQNTLKQNEKE-EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 1477 NDKLRESLSRKTVSLEH-------LQREYASVKEENERLQKEGSEKERHNQQLIQEVRCS 1529
+KL++ L++ L LQ Y +E ++LQ + +E Q+++
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 1530 GQELSRVQEEVKLRQQLLSQNDKLLQSLRV--------ELKAYEKLDEEHRRLREASGEG 1581
++LS QE++ + + +KL+Q L+ K ++L E + L++ E
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 1582 WKGQDPFRDLHSLLMEIQALRLQLERSI 1609
+ + S L EI+ ++ + E+ I
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEI 1140
Score = 58.2 bits (139), Expect = 8e-08
Identities = 135/716 (18%), Positives = 285/716 (39%), Gaps = 118/716 (16%)
Query: 949 GNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLN 1008
G L ++ VT L+ ++ +LQ LKE K +++L ++L + + + PD + +
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD 132
Query: 1009 AQPPVGAAYQ---DSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSC 1065
+ + + Q ++ E IK ++ K Q + EI D+ SL
Sbjct: 133 SSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA----AQLATEIADIKSKYDEERSLREA 188
Query: 1066 KEN-----PEDVLSPTSVATYLSSK--SQPSAK---------VSVMGTDQSESINTSNET 1109
E E++ +V L ++ +P + V V + ++ E+
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 1110 EYLKQKIHDLETELEGYQNFIFQLQ----KHSQCSEAIITVLCGTEGAQDGLSKPKNGSD 1165
E LK + L+++ + I QL+ K Q + L + + + L++ KN +
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQ-KNQTL 307
Query: 1166 GE-----EMTFSSL---HQVRYVKHVKILGPLAPEMIDSRVLEN----LKQQLEEQEYKL 1213
E E ++ L H V I L + +D + L++ + L +L
Sbjct: 308 TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVIS--R 1271
++ +L E+ ++ K++ L +++ ++L QR++ K+ HG+ + S
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHL---------KAEFKQLQQQREE-KEQHGLQLQSEIN 417
Query: 1272 QHMNTMIKAFEELLQA----SDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMN 1327
Q + +++ +L +A + +E ++ Q A+L KL +L + + ++
Sbjct: 418 QLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVT 474
Query: 1328 TQNELMERIEEDNLTY--QHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSV 1385
EL ++++ + Q L +S A +D E + +DQK
Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK---------- 524
Query: 1386 MVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELH 1445
IQ + L ++ +E+I EK R+ L + + +G T++
Sbjct: 525 -------------IQNLEALLQKSKENISLLEKEREDLYAK-IQAGEGETAVL------- 563
Query: 1446 SSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
+ L + H L++Q L L S ++ + L + + + L Q S++
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYE 1565
L + +E S +++S++ ++K + +LL + + R +L+ +
Sbjct: 624 NELNSQLNE--------------SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH- 668
Query: 1566 KLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKE 1621
LD L QD ++L+ + ++ + +L+ E S L+S LKE
Sbjct: 669 -LDTAQNAL----------QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Score = 54.3 bits (129), Expect = 1e-06
Identities = 91/479 (18%), Positives = 206/479 (43%), Gaps = 61/479 (12%)
Query: 1196 SRVLENLKQQLEE---QEYKLQKEQNL----NMQLFSEIHNLQNKF------RDLSPPRY 1242
S L++L+QQLEE + + +++ ++L QL +EI ++++K+ R+ + +
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 1243 DSLVQSQARELS---------LQRQQIKDGHGICVISRQHM-------NTMIKAFEELLQ 1286
L + +E + LQR I+D + V+ ++ + N ++ E +
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIED---VAVLKKELVQVQTLMDNMTLERERESEK 250
Query: 1287 ASDV------DYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDN 1340
D Y +E QL +EL + +++ + + + ++ NEL ++
Sbjct: 251 LKDECKKLQSQYASSEATISQLR--SELAKGPQEVAVYVQELQKLKSSVNELTQK--NQT 306
Query: 1341 LTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQ 1400
LT L E ++ S+K+ + ++D + ++ +++ L H++
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 1401 ------EIRTLRKRLEESIKTNEKLR---KQLERQGSEFVQGSTSIFASGSELHSSLTS- 1450
+ L++ L E + L+ KQL++Q E Q + + ++LHS L
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 1451 -----EIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEEN 1505
E H K+ + L++ + DK+++ L+ LSR L+ ++ +
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLM---DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYE 1565
++ +++ E++ Q ++R + +L +V ++ + Q + + LLQ + + E
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE 543
Query: 1566 KLDEE-HRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQL 1623
K E+ + +++ GE H+L ++ L +L+ E+ Q L +Q+
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 105 bits (261), Expect = 5e-22
Identities = 160/748 (21%), Positives = 304/748 (40%), Gaps = 87/748 (11%)
Query: 43 LLPNVSEETVSPTRARNMKDFENQITELKKENFNLKL-RIYFLEERMQQEFHGPTEHIYK 101
L +EET +K+ + K NL +I L+ R G +
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNS 605
Query: 102 TN-----IELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQV 156
T+ +E K ++ ELQ + QL +K + ++ E + ++ ++ +KV++
Sbjct: 606 TSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEEN 665
Query: 157 EDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMH-EGDLAMALV 215
L + LE+ + LE+ F + + + ++ +MH E D A
Sbjct: 666 STLQQR----LEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 216 LDEKDRLIEELKLSLKSKEALIQCL--KEEKSQMACPDENVSSGELRGLCAAPREEKERE 273
EK LIEEL L++K+ L L KEE+ + E EL L A +EE
Sbjct: 722 DREKGALIEEL---LQAKQDLQDLLIAKEEQEDLLRKRER----ELTALKGALKEE---- 770
Query: 274 TEAAQMEHQKERNSFEERIQALEEDLRE--KEREIATEKKNSLKRDKAIQGLTMALKSKE 331
+ E K + ++ +QAL E + E K E+ + N+ ++D+A G M +K +
Sbjct: 771 VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA--GTEMRVKLLQ 828
Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED---YETALSGKEALSAALRSQNL 388
++ E+L E+L A+ + ++ + E + E YE + E R +
Sbjct: 829 EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888
Query: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRN 448
+ L ++ LS QE+++L + L+E +K + +R L+NE+E R
Sbjct: 889 EAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQ----LRRLKNEMENERW 944
Query: 449 EVNEREKAMENRYKSLLSES-NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQN 507
+ + + ++ ++ S L Q Q+ ++ ++ + + ++ EK LE +
Sbjct: 945 HLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR 1004
Query: 508 CYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYE---------ELIQVLK 558
M +D E + + +Q +K ++ + +YE + +++K
Sbjct: 1005 LTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVK 1064
Query: 559 KEQDIYTHLVKSLQES---------------DSINNLQAELNKIFALRKQLEQDVLSYQN 603
+ +D + L L+E + + L+ EL + A R+ LE D +S +
Sbjct: 1065 QMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLER 1124
Query: 604 LRKTLEEQISEIR---RREEESFSLYSD-QTSYLSICLEENNRFQVE-HFSQEELKKKVS 658
K L+ +I + R +E + + + + L LE R + S L++KV
Sbjct: 1125 QNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVK 1184
Query: 659 DLIQLVKELYTDNQHLKKT------IFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDT 712
+L+ V D++HL T L M Q + + E ++ +E E+
Sbjct: 1185 ELVMQV-----DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQ 1239
Query: 713 IKIGEDDEINFLSDQHLQ-QSNEIMKDL 739
+ + E HLQ Q N + KDL
Sbjct: 1240 MDMNE----------HLQGQLNSMKKDL 1257
Score = 70.1 bits (170), Expect = 2e-11
Identities = 103/491 (20%), Positives = 222/491 (45%), Gaps = 69/491 (14%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKREL 117
+N++ ++ +++ ++R+ L+E ++ G +E + + +L+ ++E LK +
Sbjct: 801 KNVEVLASRSNTSEQDQAGTEMRVKLLQEE-NEKLQGRSEELERRVAQLQRQIEDLKGDE 859
Query: 118 QEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAE 177
+ ++ L K + L EA ARK ++ E + +R L E ++ AAQ
Sbjct: 860 AKAKETLKKYEGEIRQLEEA--------LVHARK--EEKEAVSARRAL--ENELEAAQGN 907
Query: 178 L-----------EKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL 226
L EK +E ++ LR RL++++ E ++ H G L + D +
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLR-RLKNEM-ENERWHLGKTIEKLQKEMADIVEASR 965
Query: 227 KLSLKSKEALIQCLKEEKSQMACPD----ENVSSGELRGLCAAPREEKERETEAAQMEHQ 282
+L+ + L + ++ + ++A E E L A +++ R E ++Q
Sbjct: 966 TSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ 1025
Query: 283 KERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIE 342
+ ++ + Q LE+ L++ E E+ E K+ LK D+ + +K E KV +L E+E
Sbjct: 1026 RAQDEALTKRQLLEQTLKDLEYEL--EAKSHLKDDR-----SRLVKQMEDKVSQLEMELE 1078
Query: 343 K-------LSAAFAKAREALQKAQT---QEFQGSEDYETALSGKEALSAALRSQ--NLTK 390
+ LS +++RE +++ + QE +D E E + L+S+ +L
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138
Query: 391 STENHR-------------LRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIR 437
S + + L ++ ++ ++LQ RLE+ ++E + ++
Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
Query: 438 DLRNE----VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTN--QKDV 491
D +++ ++ ++ +V E E+ ++ R +S + ++L Q + +HL N +KD+
Sbjct: 1199 DQKDQLSLRLKAMKRQVEEAEEEID-RLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDL 1257
Query: 492 LLQKFNEKDLE 502
L+K K L+
Sbjct: 1258 RLKKLPSKVLD 1268
Score = 61.6 bits (148), Expect = 7e-09
Identities = 146/680 (21%), Positives = 271/680 (39%), Gaps = 123/680 (18%)
Query: 1010 QPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENP 1069
QP + ++ G Q+ S+V R + + ++ E+ + A+ +N
Sbjct: 463 QPNIDGKVLETEGSQE-----STVIRAPSLGAQSKKEEEVKT--------ATATLMLQNR 509
Query: 1070 EDVLSPTSVATYLSSKSQPSAKVSVMGTD----QSESINTSNET-------EYLKQKIHD 1118
SP S A +S K+ PSA + D Q E +NE YLK+ D
Sbjct: 510 ATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTD 569
Query: 1119 LETELEGYQNFIFQ----LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE--EMTFS 1172
+ + N +F+ L+ + S C + L + K+ E E+
Sbjct: 570 NDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQ 629
Query: 1173 SLHQVRYVKHVKI--------LGPLAPEMIDSRVLEN--LKQQLEEQEYKLQKEQNLNMQ 1222
+V+ +++K L L + + +V EN L+Q+LEE E +L+K Q
Sbjct: 630 LQLEVKNQQNIKEERERMRANLEELRSQH-NEKVEENSTLQQRLEESEGELRKNLEELFQ 688
Query: 1223 LFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFE 1282
+ E Q + RDL D L + S +R + ++ + E
Sbjct: 689 VKMEREQHQTEIRDLQ----DQLSEMHDELDSAKRSEDREKGAL--------------IE 730
Query: 1283 ELLQASD--VDYCVAEGFQEQLNQCAELLEKLEKLFLNGK-SVGVEMNTQNELMERIEED 1339
ELLQA D +A+ QE +LL K E+ K ++ E+++ ++ M++++E
Sbjct: 731 ELLQAKQDLQDLLIAKEEQE------DLLRKRERELTALKGALKEEVSSHDQEMDKLKEQ 784
Query: 1340 NLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHI 1399
L ES E + + + SR + + T + V LL E
Sbjct: 785 YDAELQALRESVEEATKNV--------EVLASRSNTSEQDQAGTEMRVK-----LLQE-- 829
Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQN 1459
E L+ R EE + +L++Q+E + + ++ E+ + +H +++
Sbjct: 830 -ENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888
Query: 1460 QALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHN 1519
+A++A R + E + + +LS+ T + L + E+ E+L++ +E E
Sbjct: 889 EAVSA-----RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENER 943
Query: 1520 QQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASG 1579
L G+ + ++Q+E+ D + S L+ +LDE + R
Sbjct: 944 WHL-------GKTIEKLQKEMA---------DIVEASRTSTLELQNQLDEYKEKNR---- 983
Query: 1580 EGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQS--RLKEQLARGAEKAQEGALT- 1636
R+L + +++ L+ E+S T+ +Q RL E+ R ++AQ+ ALT
Sbjct: 984 ---------RELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTK 1034
Query: 1637 --LAVQAVSIPEVPLQPDKH 1654
L Q + E L+ H
Sbjct: 1035 RQLLEQTLKDLEYELEAKSH 1054
Score = 50.4 bits (119), Expect = 2e-05
Identities = 97/454 (21%), Positives = 185/454 (40%), Gaps = 72/454 (15%)
Query: 1208 EQEYKLQKEQNLNMQLFSE-----IHNLQNKFRDLSPP---------RYDSLVQSQAREL 1253
E KL +E+N +Q SE + LQ + DL +Y+ ++ L
Sbjct: 821 EMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEAL 880
Query: 1254 SLQRQQIKDGHGICVISRQHMNTMIKAFE-ELLQASDVDYCVAEGFQEQLNQCAELLEKL 1312
R++ K+ V +R+ + ++A + L Q + ++E +E+ Q E L +L
Sbjct: 881 VHARKEEKEA----VSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ-KEQLRRL 935
Query: 1313 EKLFLN-----GKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASH-ALSDYETSE 1366
+ N GK++ +++E L Q+ L E E + A + E
Sbjct: 936 KNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE 995
Query: 1367 KSFFSRDQKQDNETEKTSVMVNSFSQDL-LMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425
K+ E EK+ + ++ LME +E+R ++ +E++ + L + L+
Sbjct: 996 KTL---------EAEKSRLTAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKD 1044
Query: 1426 QGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLS 1485
E E S L + L KQ + + L +++ +D L E +S
Sbjct: 1045 LEYEL------------EAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
Query: 1486 RKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEV-------RCSGQEL----- 1533
R +E L+ E + + L+ + ER N+ L + R S + L
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152
Query: 1534 SRVQE-EVKLRQQLLSQNDKLLQSLRVELKAYE---KLDEEHRRLREASGEGWKGQDPFR 1589
+R+ E E +L + + + L + R+E K E ++D+EH L + K Q R
Sbjct: 1153 ARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ-----KDQLSLR 1207
Query: 1590 DLHSLLMEIQALRLQLERSIETSSTLQSRLKEQL 1623
L ++ +++ +++R + LQ L+EQ+
Sbjct: 1208 -LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQM 1240
Score = 41.2 bits (95), Expect = 0.010
Identities = 158/831 (19%), Positives = 313/831 (37%), Gaps = 138/831 (16%)
Query: 818 HLDGKTEKTP-KQKGELVHFVQTNSFSKPHDELKLSCEAQLVK---AGEVPKVGLKDASV 873
++DGK +T Q+ ++ + SK +E+K + +++ P G K SV
Sbjct: 465 NIDGKVLETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISV 524
Query: 874 QTVATEG------DLLRFKHEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPG 927
+T + DLL+ + E T++ EE TA + L
Sbjct: 525 KTFPSASNTQATPDLLKGQQELTQQTNEE----TAKQILYN-------------YLKEGS 567
Query: 928 ITNREAKKSRLPILIKPSRSL---------GNMYRLPATQEVVTQLQS------QILELQ 972
N +A K ++ ++ + ++L GN +T EV L+ ++ ELQ
Sbjct: 568 TDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQ 627
Query: 973 GELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGE-QKGIKTTS 1031
+L+ + + ++ A +E + + + ++S GE +K ++
Sbjct: 628 RQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF 687
Query: 1032 SVWRDKE-------------------MDS-----DQQRSYEIDSEICPPDDLASLPSCKE 1067
V ++E +DS D+++ I+ + DL L KE
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE 747
Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127
ED+L + + ++ G + E + E + LK++ + EL+ +
Sbjct: 748 EQEDLL-----------RKRERELTALKGALKEEVSSHDQEMDKLKEQY---DAELQALR 793
Query: 1128 NFIFQLQKHSQC----SEAIITVLCGTEGAQDGLSKPKNGSDG--EEMTFSSLHQVRYVK 1181
+ + K+ + S GTE L + G EE+ R ++
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 1182 HVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHN-LQNKFRDLSPP 1240
+K G A + E +QLEE +KE+ + + N L+ +LS
Sbjct: 854 DLK--GDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQT 911
Query: 1241 RYDSLVQSQA-RELSLQRQQIKDGHGICVISRQHMNTMI----KAFEELLQAS-----DV 1290
+ S+ +E S Q++Q++ R H+ I K ++++AS ++
Sbjct: 912 TQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLEL 971
Query: 1291 DYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPES 1350
+ E ++ + AE+ +L++ L + + + M +EE+ YQ E+
Sbjct: 972 QNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEA 1031
Query: 1351 --PEPSASHALSD--YETSEKSFFSRDQKQ--DNETEKTSVMVNSFSQ-----DLLMEHI 1399
L D YE KS D+ + +K S + + DLL E I
Sbjct: 1032 LTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERI 1091
Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLE-------RQGSEF------VQGSTSIFASG----- 1441
R ++L + R+ LE RQ + ++GS G
Sbjct: 1092 SRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQM 1151
Query: 1442 ----SELHSSLTSEIHF---LRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL 1494
+EL L SE L+ N+ L + + E+ L + + ++ L+ +
Sbjct: 1152 EARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAM 1211
Query: 1495 QREYASVKEENERLQKEGSEKERH-NQQLIQEVRCSGQELSRVQEEVKLRQ 1544
+R+ +EE +RL+ + +R +Q+ GQ L+ ++++++L++
Sbjct: 1212 KRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ-LNSMKKDLRLKK 1261
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 103 bits (258), Expect = 1e-21
Identities = 139/658 (21%), Positives = 278/658 (42%), Gaps = 101/658 (15%)
Query: 60 MKDFENQITE-------LKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVES 112
+ D E+++ E L+ E ++ I LEE++ +E G + + + + +++
Sbjct: 924 LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE-EGARQKLQLEKVTAEAKIKK 982
Query: 113 LKRE---LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARK--KVQQVEDLLTKRILLL 167
++ E L+++ IK K +E S++ +E A+ K++ ++++ +
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK 227
K + ELEKA + +L+ + ++++ + E I+ELK
Sbjct: 1043 LKKEEKTRQELEKA----------KRKLDGETTDLQDQ----------IAELQAQIDELK 1082
Query: 228 LSLKSKEALIQCLKEEKSQMACPDENVSS--GELRGLCAAPREEKERETEAAQMEHQKER 285
L L KE +Q N EL+ A +E+ E E +A++ + +K++
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQK 1141
Query: 286 NSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLS 345
E ++AL+ +L + A +++ KR++ + L AL+ + K E ++I+ +
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE---AQIQDMR 1198
Query: 346 AAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKIT 405
A A E L SE E A + A L T+N L +K +
Sbjct: 1199 QRHATALEEL----------SEQLEQA----KRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 406 QELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLL 465
Q ++ + +R++L+ ++E H + S+GD +L + KL+NE+ + +LL
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL--------DNVSTLL 1296
Query: 466 SESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLIT 525
E+ KK + L LLQ+ + L +L R L
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL-------------NLSSRIRQLEE 1343
Query: 526 EKCSSQQPPGSKTIFSKE-KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAEL 584
EK S Q+ + K +KQ + + KK+ D ++SL+E+ AE
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE- 1402
Query: 585 NKIFALRKQLEQDVLSYQNLRKT---LEEQI--------------SEIRRREEESFSLYS 627
AL ++LE+ L+Y L KT L++++ S + +++++ L +
Sbjct: 1403 ----ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 628 DQTSYLSICLEENNRFQVEHFSQE----ELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
++ S + EE +R + E +E L + + + ++ +E N+ L+ + DL
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 95.1 bits (235), Expect = 6e-19
Identities = 131/581 (22%), Positives = 250/581 (43%), Gaps = 63/581 (10%)
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-RILLLEKDVTAAQAELE-KA 181
L++ ++ E L +A E+ +VKE K ++E++ K + LL EK++ A Q + E +
Sbjct: 844 LLQVTRQEEEL-QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902
Query: 182 FAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLK 241
FA E +R RL +K E++++ + +E++++++ K K +A IQ L+
Sbjct: 903 FAEAE---EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK---KKMQAHIQDLE 956
Query: 242 EEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-----KERNSFEERIQALE 296
E+ + +E A + K+ E E +E Q KE+ E+RI
Sbjct: 957 EQLDE----EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
L E+E + K K++ I L LK +EK +EL KL ++ +
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072
Query: 357 KAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415
+ Q Q ++ + L+ K E L AL + +N+ L K+ +E LQ +
Sbjct: 1073 ELQAQ----IDELKLQLAKKEEELQGALARGDDETLHKNNAL-----KVVRE---LQAQI 1120
Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNE--------------REKAMENRY 461
L++D E ++K + RDL E+E L+ E+ + RE+ +
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 462 KSLLSES-NKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRS 520
K+L E+ N + Q+ +H T + L Q K +++N + ++ EL
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK--ANLEKNKQGLETDNKELAC 1238
Query: 521 EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNL 580
E + ++ ++ K KK + +EL + + + L ++ + L
Sbjct: 1239 EVKVLQQVKAESE-------HKRKKLDAQVQELHAKVSEGDRLRVEL------AEKASKL 1285
Query: 581 QAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEEN 640
Q EL+ + L ++ E+ + + +LE Q+ + + +E + +S + EE
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 641 NRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
N Q + +EE +K + + ++ D + KK DL
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTK--KKVDDDL 1384
Score = 76.3 bits (186), Expect = 3e-13
Identities = 131/621 (21%), Positives = 254/621 (40%), Gaps = 105/621 (16%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEER------MQQEFHGPTEHIYKTNIELKVEVESL 113
++D + + E ++ NL RI LEE Q+E +++ K + L+ ++
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 114 KRE----------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK- 162
K++ L+E ++ L+K ++A+ E ++++ + Q+++DL
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 163 ------------------RILLLEKDVTAAQAE---------LEKAFAGTETEKALRLRL 195
++L EK ++A AE EK +AL L
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
E+K ++ + M ++ KD + + + KSK AL Q ++E ++Q+ ++ +
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Query: 256 SGELRGLCAAPREEKERETEAAQMEH--QKERNSFEERIQALEEDLREKEREIATEKKNS 313
+ E L R E + AQ E Q EE+ + L + +RE E E+ E+K
Sbjct: 1557 ATEDAKL----RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ- 1611
Query: 314 LKRDKAIQGLTMALKSK-EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETA 372
+ L +A K K E +++L ++IE A KAR+ + K + +DY+
Sbjct: 1612 -------RALAVASKKKMEIDLKDLEAQIE----AANKARDEVIKQLRKLQAQMKDYQRE 1660
Query: 373 LSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKG 432
L + A R + +S E+ + +K + E+ LQ+E E+ A +E+
Sbjct: 1661 LEE----ARASRDEIFAQSKES---EKKLKSLEAEILQLQEELASSERARRHAEQER--- 1710
Query: 433 DCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ-EQVIKHLTESTNQKDV 491
++L +E+ KS L + ++L + Q+ + L E + ++
Sbjct: 1711 -----------DELADEITNSASG-----KSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 492 LLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITE--------KCSSQQPPGS-----KT 538
L +F + L+V N L A +S+ + K Q+ G+ K
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814
Query: 539 IFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA--LRKQLEQ 596
S + + EE ++ KE+ LV+ ++ +Q E + A ++Q+E+
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK 1874
Query: 597 DVLSYQNLRKTLEEQISEIRR 617
+ L++ LEE E R
Sbjct: 1875 ANARMKQLKRQLEEAEEEATR 1895
Score = 71.2 bits (173), Expect = 9e-12
Identities = 257/1286 (19%), Positives = 489/1286 (38%), Gaps = 286/1286 (22%)
Query: 332 KKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQN-LTK 390
++ EEL ++ E+L K +E K + + + ++ L K L+ L+++ L
Sbjct: 849 RQEEELQAKDEEL----LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEV 450
E R R + KK QE E + DLE R E E+ RN++
Sbjct: 905 EAEEMRARLAAKK---------QELEEILHDLES---------------RVEEEEERNQI 940
Query: 451 NEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYL 510
+ EK + ++ + + ++L +E + L + ++K E+ L + QN
Sbjct: 941 LQNEK---KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF 997
Query: 511 MAAEDLELRSEGLITEKCSSQ---QPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHL 567
+ + L E I E CSSQ + +K + KQ +L + LKKE+ L
Sbjct: 998 IKEKKL---MEDRIAE-CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 568 VKSLQESDS-INNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLY 626
K+ ++ D +LQ ++ ++ Q + D L Q L K EE + R ++E+
Sbjct: 1054 EKAKRKLDGETTDLQDQIAEL-----QAQIDELKLQ-LAKKEEELQGALARGDDET---- 1103
Query: 627 SDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGF 686
L +NN +V EL+ ++++L + + +K DLS
Sbjct: 1104 ----------LHKNNALKVVR----ELQAQIAELQEDFESEKASRNKAEKQKRDLS---- 1145
Query: 687 QGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKN 746
E+ E L ++ ++ E+ +Q + + + +++ +K
Sbjct: 1146 ------------EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK----- 1188
Query: 747 GYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRPDLLKVVRELLLGQ 806
+ E++I D HA LEE
Sbjct: 1189 ----NHEAQIQDMRQRHATA-LEE------------------------------------ 1207
Query: 807 LFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDELKLSCEA---QLVKAGEV 863
L+EQ + EK N D +L+CE Q VKA
Sbjct: 1208 --LSEQLEQAKRFKANLEK--------------NKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 864 PKVGLKDASVQTV---ATEGDLLRFK--HEATREAWEEKPINTALSAEHRP--ENLHGVP 916
K DA VQ + +EGD LR + +A++ E ++T L + +
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 917 GWQAALLSLPGITNREAKK-----SRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILEL 971
++ L + E ++ SR+ L + SL +E L+ Q+L L
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE--EEEEARKNLEKQVLAL 1369
Query: 972 QGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTS 1031
Q +L + K K++ L E++ E + K L +A+ + + K KT +
Sbjct: 1370 QSQLADTK---KKVDDDLGTIESLEEAKK---KLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 1032 SVWR---DKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQP 1088
+ + D +D D QR +AS K+ D L L+ +
Sbjct: 1424 RLQQELDDLTVDLDHQRQ------------VASNLEKKQKKFDQL--------LAEEKSI 1463
Query: 1089 SAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLC 1148
SA+ + D++E+ ET+ L LE LE + F Q ++ E +++
Sbjct: 1464 SARYAEE-RDRAEAEAREKETKALSLA-RALEEALEAKEEFERQNKQLRADMEDLMS--- 1518
Query: 1149 GTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEE 1208
++D + K ++H++ K + +E ++ QLEE
Sbjct: 1519 ----SKDDVGK-------------NVHELEKSKRAL-----------EQQVEEMRTQLEE 1550
Query: 1209 QEYKLQKEQNLNMQLFSEIHNLQNKF------RDLSPPRYDSLVQSQARELSLQRQQIKD 1262
E +LQ ++ ++L + ++ +F RD L+ Q REL + + +
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610
Query: 1263 GHGICVISRQHMNTMIKAFEELLQASDV--DYCVAE---------GFQEQLNQC------ 1305
+ V S++ M +K E ++A++ D + + +Q +L +
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 1306 ----------------AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPE 1349
AE+L+ E+L + ++ ++EL + I LL E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEH--IQEIRTLRK 1407
A A + E E+ S + ++ KT++ V++ + +L E Q+ R+
Sbjct: 1731 KRRLEARIAQLEEELEEEQ--SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ 1788
Query: 1408 RLEESIKTNEKLRKQL-ERQG---SEFVQGSTSIFASGSELHSSLTSEI-------HFLR 1456
+LE + N++L+ +L E +G S+F +++ A +L L E +R
Sbjct: 1789 QLE---RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE-------NERLQ 1509
+ + L + ++ D+++ D+ +E + + ++ L+R+ +EE +LQ
Sbjct: 1846 RTEKKLKEIFMQ-VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSR 1535
+E + N+ L +EV L R
Sbjct: 1905 RELDDATEANEGLSREVSTLKNRLRR 1930
Score = 68.2 bits (165), Expect = 7e-11
Identities = 113/508 (22%), Positives = 211/508 (41%), Gaps = 107/508 (21%)
Query: 57 ARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRE 116
A N++ + + +L E ++ R + EER + E + ++ +E +E
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISAR--YAEERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 117 LQEREQLLIKAS-KAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
ER+ ++A + + S + G + +++ R QQVE++ T+ LE
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ----LE------- 1549
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDR--LIEELK------ 227
ELE TE K LRLE + MK E DL +E+ + LI++++
Sbjct: 1550 -ELEDELQATEDAK---LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL 1605
Query: 228 --------LSLKSKEALIQCLKEEKSQMACP----DENVSSGELRGLCAAPREEKERETE 275
L++ SK+ + LK+ ++Q+ DE + +LR L A ++ +RE E
Sbjct: 1606 EDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK--QLRKL-QAQMKDYQRELE 1662
Query: 276 AAQM----------EHQKERNSFEERIQALEEDLREKER----------EIATEKKNSLK 315
A+ E +K+ S E I L+E+L ER E+A E NS
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSAS 1722
Query: 316 RDKAIQGLTMALKSK----EKKVEELNSEIEKLSAAFAK--------------------- 350
A+ L+++ E+++EE S +E L+ F K
Sbjct: 1723 GKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK 1782
Query: 351 ---AREALQ------KAQTQEFQGS--EDYETALSGKEA----LSAALRSQNLTKSTENH 395
AR+ L+ KA+ QE +G+ ++ +S EA L L + ++ N
Sbjct: 1783 SDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANK 1842
Query: 396 RLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK 455
+RR+ KK+ + ++ ER ++ E + K + ++ L+ ++E+ E
Sbjct: 1843 LVRRTEKKLKEIFMQVEDERRHADQYKE----QMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 456 AMENRYKSL--LSESNKKLHNQEQVIKH 481
+ + L +E+N+ L + +K+
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKN 1926
Score = 66.2 bits (160), Expect = 3e-10
Identities = 126/616 (20%), Positives = 255/616 (41%), Gaps = 85/616 (13%)
Query: 1087 QPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEG-------YQNFIFQLQKHSQC 1139
Q A+ + + + + + L++ +HDLE+ +E QN ++Q H Q
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 1140 SEAIITVLCGTEGAQDGLSKPKNGSDG------EEMTFSSLHQVRYVKHVKIL------- 1186
E L EGA+ L K ++ EE+ +++K K++
Sbjct: 955 LEE---QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 1187 -GPLAPEMIDSRVLENLKQQLE----EQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPR 1241
LA E ++ L ++ + E + E +L+KE+ +L L + DL
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 1242 YDSLVQSQARELSLQ----RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG 1297
+ +Q+Q EL LQ ++++ H N +K EL QA + + E
Sbjct: 1072 AE--LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-QAQIAE--LQED 1126
Query: 1298 FQEQL-------NQCAELLEKLEKL------FLNGKSVGVEMNTQNE-----LMERIEED 1339
F+ + Q +L E+LE L L+ + E+ T+ E L + +EE+
Sbjct: 1127 FESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE 1186
Query: 1340 NLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHI 1399
++ + + + HA + E SE+ ++ K + E K + ++ E
Sbjct: 1187 TKNHEAQIQDMRQ---RHATALEELSEQLEQAKRFKANLEKNKQGLETDN------KELA 1237
Query: 1400 QEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGS---TSIFASGSELHSSLTSEIHFLR 1456
E++ L++ ES +KL Q++ ++ +G + S+L + L + + L
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDN-VSTLL 1296
Query: 1457 KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKE 1516
++ + K + + + +E L +T +L ++EE LQ++ E+E
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 1517 RHNQQLIQEVRCSGQELSRVQEEV-----------KLRQQLLSQNDKLLQSLRVELKAYE 1565
+ L ++V +L+ +++V + +++LL + L Q L + AY+
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 1566 KLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLAR 1625
KL++ RL++ + D R + S L + Q + ++ + ++ +R E+ R
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK---KFDQLLAEEKSISARYAEERDR 1473
Query: 1626 GAEKAQE---GALTLA 1638
+A+E AL+LA
Sbjct: 1474 AEAEAREKETKALSLA 1489
Score = 63.9 bits (154), Expect = 1e-09
Identities = 150/735 (20%), Positives = 291/735 (39%), Gaps = 109/735 (14%)
Query: 962 TQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSP 1021
T LQ QI ELQ ++ E K + ++L A+ G D+TL
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEEL--QGALARG---DDETL------------HKN 1107
Query: 1022 GEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATY 1081
K ++ + + + D + +++ +E D L + K ED L T+
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQK----IHDLETELEGYQNFIFQLQKHS 1137
L +K + + + E+ N + + ++Q+ + +L +LE + F L+K+
Sbjct: 1168 LRTKREQEV-AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 1138 QCSEAIITVL-CGTEGAQDGLSKPKNGSDGEEMTFSSLH-QVRYVKHVKI-LGPLAPEMI 1194
Q E L C + Q ++ ++ + LH +V +++ L A ++
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 1195 DSRVLENLKQQLEEQEYK--------------LQKEQNLNMQLFSEIHNLQNKFRDLSPP 1240
+ L+N+ LEE E K LQ Q L + + NL ++ R L
Sbjct: 1287 NE--LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344
Query: 1241 RYDSLVQSQARELSLQR---QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEG 1297
+ +SL + Q E ++ +Q+ +++ ++ + E L +A AE
Sbjct: 1345 K-NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 1298 FQEQLNQCAELLEKLEK----LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEP 1353
++L + A +KLEK L + V+++ Q ++ +E+ + LL E
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 1354 SASHA----LSDYETSEKSF------------------FSRDQKQ------DNETEKTSV 1385
SA +A ++ E EK F R KQ D + K V
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523
Query: 1386 MVNSF----SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
N S+ L + ++E+RT + LE+ ++ E + +LE +
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE--------------VNM 1569
Query: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
+ + ++ +QN+ +LIK R+ + E + R+ + S + ++ + +
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 1502 KEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQ---NDKLLQSLR 1558
+ + E K E + ++L +++ +EL +E R ++ +Q ++K L+SL
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQREL---EEARASRDEIFAQSKESEKKLKSLE 1686
Query: 1559 VE-LKAYEKLDEEHRRLREASGEGWKGQDPFRDLHS----LLME---IQALRLQLERSIE 1610
E L+ E+L R R A E + D + S LL E ++A QLE +E
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE 1746
Query: 1611 TSSTLQSRLKEQLAR 1625
+ L ++ +
Sbjct: 1747 EEQSNMELLNDRFRK 1761
Score = 56.6 bits (135), Expect = 2e-07
Identities = 107/508 (21%), Positives = 210/508 (41%), Gaps = 86/508 (16%)
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGS---EFVQGSTSIFASGSELHSSLTSE-- 1451
E + +++ + ++E ++ E+ +QL + + E +Q T +FA E+ + L ++
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 1452 -----IHFLR---KQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKE 1503
+H L ++ + N +L + Q L E L + + + LQ E + +
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978
Query: 1504 ENERLQKEGSEKERHNQQLIQEVR--------CSGQELSRVQEEVKLRQQLLSQNDKLLQ 1555
+ +++++E E N + I+E + CS Q L+ +E+ K ++ ++ + ++
Sbjct: 979 KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ-LAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 1556 SLRVELKAYEKLDEE-HRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSST 1614
L LK EK +E + R+ GE QD +L + +I L+LQL + E
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQA---QIDELKLQLAKKEE---- 1090
Query: 1615 LQSRLKEQLARGAEKA--QEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDS 1672
L+ LARG ++ + AL + V+ + LQ D F+S
Sbjct: 1091 ---ELQGALARGDDETLHKNNALKV-VRELQAQIAELQED-----------------FES 1129
Query: 1673 SQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIE 1732
+A K+ + LS + ++L + + +T L T ++ + + +
Sbjct: 1130 EKASRNKAEKQKRDLS-EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 1733 DYEALLKQISQGQRL-LAEMDIQTQEAP------SSTSQELGTKGPHPAPLSKFVSSVST 1785
++EA ++ + Q L E+ Q ++A Q L T A K + V
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 1786 AKLTLEEAYRRLKLLWRVS-----LPEDGQCPLH-CEQIGEMKAEVTKLHKKLFEQEKK- 1838
E ++R KL +V + E + + E+ +++ E+ + L E EKK
Sbjct: 1249 -----ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 1839 -------------LQNTMKLLQLSKRQE 1853
LQ+T +LLQ RQ+
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEETRQK 1331
Score = 54.3 bits (129), Expect = 1e-06
Identities = 120/624 (19%), Positives = 229/624 (36%), Gaps = 97/624 (15%)
Query: 1282 EELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVE-MNTQNELMERIEEDN 1340
EE LQA D + + Q ++ E +E+ + L K++ E + + EL EE
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 1341 LTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEH-- 1398
E E L D E+ + R+Q NE +K + + L E
Sbjct: 911 ARLAAKKQELEE-----ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 1399 IQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT--------- 1449
Q+++ + E IK E+ LE Q S+F++ + +E S L
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 1450 -----------SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREY 1498
S++ K+ + L K R E L++ ++ ++ L+ +
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085
Query: 1499 ASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLR 1558
A +EE + G ++ H ++ VR +++ +QE+ + + ++ +K + L
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 1559 VELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSI-ETSSTLQS 1617
EL+A + E+ A Q LR + E+ + E L+
Sbjct: 1146 EELEALKTELEDTLDTTAAQ--------------------QELRTKREQEVAELKKALEE 1185
Query: 1618 RLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVT 1677
K A+ + Q A L + + + + +K +E+DN A
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN------KELACE 1239
Query: 1678 PKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEAL 1737
K + + S + L V H S+ R + L E L
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQ--------------VQELHAKVSEGDRLRVELAEKASKL 1285
Query: 1738 LKQISQGQRLLAEMDIQ----TQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEA 1793
++ LL E + + ++A S SQ T +L EE
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQ-----------------LQDTQELLQEET 1328
Query: 1794 YRRLKLLWRVSLPEDGQCPLHCEQIGEMKA------EVTKLHKKLFEQEKKLQNTMKLLQ 1847
++L L R+ E+ + L +Q E +A +V L +L + +KK+ + + ++
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE 1388
Query: 1848 -LSKRQEKVIFDQLVVTHKILRKA 1870
L + ++K++ D ++ ++ KA
Sbjct: 1389 SLEEAKKKLLKDAEALSQRLEEKA 1412
Score = 46.6 bits (109), Expect = 2e-04
Identities = 91/453 (20%), Positives = 179/453 (39%), Gaps = 94/453 (20%)
Query: 58 RNMKDFENQITELKKE---NFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELK----VEV 110
+ +++ Q+ EL+ E + KLR+ + M+ +F + + N E K +V
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 111 ESLKRELQE--REQLLIKASKA--------VESLAEAGGSEIQRVKEDARKKVQQVEDLL 160
L+ EL++ +++ L ASK +E+ EA V + RK Q++D
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY- 1657
Query: 161 TKRILLLEKDVTAAQAELEKAFAGT-ETEKALRLRLESKLSEMKKMHEGDLAMALVLDEK 219
++++ A+A ++ FA + E+EK L+ L +++ + A E+
Sbjct: 1658 -------QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 220 DRLIEELKLSLKSKEALI--------------QCLKEEKSQMACPDEN-----VSSGELR 260
D L +E+ S K AL+ + L+EE+S M ++ + L
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 261 GLCAAPREEKERETEAAQ-MEHQKER--------------------NSFEERIQALEEDL 299
AA R ++ A Q +E Q + ++ E +I LEE L
Sbjct: 1771 AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQL 1830
Query: 300 REKEREIATEKKNSLKRDKAIQGLTMA---------------------LKSKEKKVEELN 338
++ +E A K + +K ++ + M +K ++++EE
Sbjct: 1831 EQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE 1890
Query: 339 SEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLR 398
E + +A+ K + L A T+ +G + L + + S+ + R +
Sbjct: 1891 EEATRANASRRKLQRELDDA-TEANEGLSREVSTLKNRLRRGGPIS----FSSSRSGRRQ 1945
Query: 399 RSIKKITQELSDLQQERERLEKDLEEAHREKSK 431
++ + ELSD + E D+ E +S+
Sbjct: 1946 LHLEGASLELSD--DDTESKTSDVNETQPPQSE 1976
Score = 43.9 bits (102), Expect = 0.001
Identities = 34/143 (23%), Positives = 70/143 (48%), Gaps = 5/143 (3%)
Query: 1484 LSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQE---EV 1540
++R+ L+ E VKE+ +++ E E ER +QQL++E ++L E E
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 1541 KLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQA 1600
+ + L+ + L+ + +L++ +++EE R + E K Q +DL L E +
Sbjct: 907 EEMRARLAAKKQELEEILHDLES--RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 1601 LRLQLERSIETSSTLQSRLKEQL 1623
R +L+ T+ +++E++
Sbjct: 965 ARQKLQLEKVTAEAKIKKMEEEI 987
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5
[Homo sapiens]
Length = 1132
Score = 103 bits (257), Expect = 2e-21
Identities = 116/488 (23%), Positives = 224/488 (45%), Gaps = 43/488 (8%)
Query: 202 MKKMHEGDLAMALVLDEKDRLIEEL---KLSLKSKEALIQCLKEEK---SQMACPDENVS 255
+K +++ ++ L L + L ++L L L+ + + LK++K + ++VS
Sbjct: 341 LKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVS 400
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLK 315
L L +EK ++TEA + L+E L E E+ +++S K
Sbjct: 401 DSHLAEL-----QEKIQQTEATN--------------KILQEKLNEMSYELKCAQESSQK 441
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSG 375
+D IQ L LKS+E++ EEL IE + AK RE L ++Q + SE T+ +
Sbjct: 442 QDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEG--TSPAQ 499
Query: 376 KEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCT 435
++ L+S E +L+R +++ ++L+D +Q + +E E+ ++K
Sbjct: 500 QQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKH 559
Query: 436 IRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQK 495
++LR +++L+ E+ + + + ++ +E ++ QEQ I+HL S + K+ LLQ+
Sbjct: 560 NQELRKALQQLQEELQNKSQQL----RAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQE 615
Query: 496 FNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQ 555
F E + L A E L + I +K + + + + E+K+ + +
Sbjct: 616 FRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA 675
Query: 556 VLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS--YQNLRKTLEEQIS 613
V +++ D+ + L++ S N + + K LE + LS QNL+ EE +
Sbjct: 676 VRERDHDL-----ERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMET 730
Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
+ R ++E S+ L L + N+ +VE S L K ++ +EL Q
Sbjct: 731 KFSRWQKEQESIIQQ----LQTSLHDRNK-EVEDLSATLLCKLGPGQSEIAEELCQRLQR 785
Query: 674 LKKTIFDL 681
++ + DL
Sbjct: 786 KERMLQDL 793
Score = 69.7 bits (169), Expect = 3e-11
Identities = 144/715 (20%), Positives = 294/715 (41%), Gaps = 125/715 (17%)
Query: 26 VPDDLDGINPNAGLGNGLLPNVSEETVSP------TRARNMKDFENQITELKKENFNLKL 79
V L G P + +G+ ++ P + + D + +L ++ L++
Sbjct: 315 VKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLRV 374
Query: 80 RIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGG 139
+ E QQ+ + ++T I + +S ELQE+ Q +K ++
Sbjct: 375 QPMTEELLKQQKLNS-----HETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMS 429
Query: 140 SEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKL 199
E++ +E ++K+ +++L ++ + + + E E+ + E + +L L
Sbjct: 430 YELKCAQESSQKQDGTIQNL--------KETLKSRERETEELYQVIEGQNDTMAKLREML 481
Query: 200 --SEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL----KEEKSQMACPDEN 253
S++ ++H + ++ + +L+ +L + IQ L ++++ Q+A +
Sbjct: 482 HQSQLGQLHSSEGTSPA---QQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQC 538
Query: 254 VSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIAT---EK 310
V E A E E++ EA+ +Q+ R + +Q L+E+L+ K +++ EK
Sbjct: 539 VQFVE------AAAHESEQQKEASWKHNQELRKA----LQQLQEELQNKSQQLRAWEAEK 588
Query: 311 KNSLK-RDKAIQGLTMALKSKEKKVEEL--------NSE---------IEKLSAAFAKAR 352
N ++ +++ IQ L +L KE+ ++E NS+ +EKL
Sbjct: 589 YNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKA 648
Query: 353 EALQKAQTQEFQGSEDYETALS-----------GKEALSAALRSQNLTKSTENHRLRRS- 400
AL++A ++F E+ E L E L L S T + LR
Sbjct: 649 VALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKG 708
Query: 401 --IKKITQELSDLQQERERLEKDLEEAHREKS----KGDCTIRDLRNEVEKLR------- 447
+++++ +LQ +E +E +E+ + ++ D EVE L
Sbjct: 709 LEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKL 768
Query: 448 --------NEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEK 499
E+ +R + E + LLS+ NK++ E I+ L +S + ++ Q EK
Sbjct: 769 GPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAAAEK 828
Query: 500 DLE-VIQQNCYLMAAEDL-----ELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL 553
++ ++++N L A L S+ I+ + + P G K+ Q S
Sbjct: 829 LVQALMERNSELQALRQYLGGRDSLMSQAPISNQQAEVTPTG---CLGKQTDQGS----- 880
Query: 554 IQVLKKEQDIYTHLVKSLQESDSI-NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQI 612
+Q+ +D T L + +E SI + +L+ + L K+L +E++
Sbjct: 881 MQI--PSRDDSTSL--TAKEDVSIPRSTLGDLDTVAGLEKEL-----------SNAKEEL 925
Query: 613 SEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKEL 667
+ ++E ES S S +++ EE QV+ E L + + L+K+L
Sbjct: 926 ELMAKKERESQMELSALQSMMAVQEEE---LQVQAADMESLTRNIQIKEDLIKDL 977
Score = 45.4 bits (106), Expect = 5e-04
Identities = 84/382 (21%), Positives = 152/382 (39%), Gaps = 63/382 (16%)
Query: 1308 LLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETS-- 1365
L L+ L+ S +E++ EL + + ED L + + P + E L+ +ET+
Sbjct: 337 LNRSLKPLYKTPVSYPLELSDLQELWDDLCEDYLPLR-VQPMTEELLKQQKLNSHETTIT 395
Query: 1366 ----EKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRK 1421
S + Q++ +TE T N Q+ L E E++ ++ ++ T + L++
Sbjct: 396 QQSVSDSHLAELQEKIQQTEAT----NKILQEKLNEMSYELKCAQESSQKQDGTIQNLKE 451
Query: 1422 QL---ERQGSEF---VQGSTSIFASGSE-LHSSLTSEIHFLRKQNQA--------LNAML 1466
L ER+ E ++G A E LH S ++H + A L + L
Sbjct: 452 TLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSAL 511
Query: 1467 IKGSRDKQKENDKLR---------------------ESLSRKTVSLEHLQREYASVKEEN 1505
+ QK +R ES +K S +H Q ++++
Sbjct: 512 FCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQ 571
Query: 1506 ERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQ---SLRVELK 1562
E LQ + + + E+R Q + + + ++QLL + +LLQ + L+
Sbjct: 572 EELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLE 631
Query: 1563 AYEKLDEEHRR--------LREASGEGWKG-QDPFRDLHSLLMEIQALRLQLERSIETSS 1613
A E L E+ R+ L A E + ++ ++L L + ++ LER + S
Sbjct: 632 ANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLS 691
Query: 1614 ----TLQSRLKEQLARGAEKAQ 1631
T+QS A+G E Q
Sbjct: 692 SNEATMQSMESLLRAKGLEVEQ 713
Score = 40.4 bits (93), Expect = 0.017
Identities = 112/521 (21%), Positives = 206/521 (39%), Gaps = 94/521 (18%)
Query: 1199 LENLKQQL---EEQEYKLQKEQNLNMQLFSEIHNLQNK------FRDLSPPRYDSLVQSQ 1249
L+N QQL E ++Y + Q N+Q + H+L +K FR+L R +S +
Sbjct: 574 LQNKSQQLRAWEAEKYNEIRTQEQNIQHLN--HSLSHKEQLLQEFRELLQYRDNSDKTLE 631
Query: 1250 ARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELL 1309
A E+ L++ RQ ++ A E +A D + E +++L Q +
Sbjct: 632 ANEMLLEKL------------RQRIHDKAVALE---RAIDEKFSALEEKEKELRQLRLAV 676
Query: 1310 EK----LEKLFLNGKSVGVEMNTQNELME----RIEEDNLTYQHL--LPESPEPSASHAL 1359
+ LE+L S M + L+ +E+ + T Q+L L E E S
Sbjct: 677 RERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQ 736
Query: 1360 SDYETSEKSFFSRDQKQDNETEKTSVMV----------------------NSFSQDLL-- 1395
+ E+ + + ++ E E S + QDLL
Sbjct: 737 KEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSD 796
Query: 1396 -----MEHIQEIRTLRK----RLEESIKTNEKLRKQLERQGSE------FVQGSTSIFAS 1440
+EH EI+ L + R +ES EKL + L + SE ++ G S+ +
Sbjct: 797 RNKQVLEHEMEIQGLLQSVSTREQESQAAAEKLVQALMERNSELQALRQYLGGRDSLMSQ 856
Query: 1441 G--SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTV----SLEHL 1494
S + +T ++ +Q +M I D K S+ R T+ ++ L
Sbjct: 857 APISNQQAEVTPTGCLGKQTDQG--SMQIPSRDDSTSLTAKEDVSIPRSTLGDLDTVAGL 914
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLL 1554
++E ++ KEE E + K+ E + L + +EL +++ + + + L+
Sbjct: 915 EKELSNAKEELELMAKKERESQMELSALQSMMAVQEEELQVQAADMESLTRNIQIKEDLI 974
Query: 1555 QSLRVEL------KAYEKLDEEHRRLRE--ASGEGWKGQDPFRDLHSLLMEIQAL---RL 1603
+ L+++L A E+L +E LRE AS E + LL+ ++ L R
Sbjct: 975 KDLQMQLVDPEDIPAMERLTQEVLLLREKVASVESQGQEISGNRRQQLLLMLEGLVDERS 1034
Query: 1604 QLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSI 1644
+L +++ L S L + A ++ L + ++ +
Sbjct: 1035 RLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV 1075
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 102 bits (254), Expect = 4e-21
Identities = 330/1641 (20%), Positives = 651/1641 (39%), Gaps = 253/1641 (15%)
Query: 58 RNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRE- 116
+ M+ E++I ++ K+ + + L R Q++ + I + LK+E L+
Sbjct: 306 KKMEQLEDKIKDINKKLSSAENDRDILR-REQEQLNVEKRQIMEECENLKLECSKLQPSA 364
Query: 117 ------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL----------- 159
+ E+E++L +++ E +Q+ DA ++ ++ L
Sbjct: 365 VKQSDTMTEKERILAQSASVEEVF------RLQQALSDAENEIMRLSSLNQDNSLAEDNL 418
Query: 160 -LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDE 218
L RI +LEK+ + E E E + +L L+L ++ +K D+++
Sbjct: 419 KLKMRIEVLEKEKSLLSQEKE------ELQMSL-LKLNNEYEVIKSTATRDISL------ 465
Query: 219 KDRLIEELKLSLKSKEA-LIQCLKEEKSQMACPDE----NVSSGELRGLCAAPREEKERE 273
D + +L+L+L++KE L Q + E+++ +A +E N + + L +++ E
Sbjct: 466 -DSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524
Query: 274 TEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKK 333
++ + +++ N ++R+ LE+D + +E+ +K+ ++ + A+ L + + E K
Sbjct: 525 GDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584
Query: 334 VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLT-KST 392
VE L ++ K + ++ + + +E + E + E + + + N K T
Sbjct: 585 VENLVDQLNKSQESNVSIQK--ENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642
Query: 393 ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNE---------- 442
++ + Q LS+L+Q E L+K + E K D+R++
Sbjct: 643 LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ 702
Query: 443 --------VEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ 494
VE L+ E E E + K LL E+NK E+ I+ L+ + N LQ
Sbjct: 703 LSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANK----YEKTIEELSNARNLNTSALQ 758
Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELI 554
+E +++ Q+ +D+E+ E+ + + S ++Q ++L
Sbjct: 759 LEHEHLIKLNQK-------KDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ----KQLT 807
Query: 555 QVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF-ALRKQLEQDVLSYQNLRKTLEEQIS 613
Q++ K++ ++ L+E S LQ EL+K ALRK + LR+T+EE+
Sbjct: 808 QLINKKE----IFIEKLKERSS--KLQEELDKYSQALRKN--------EILRQTIEEKDR 853
Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
+ +EE+ L + L EE +R + + V++L V +L T +H
Sbjct: 854 SLGSMKEENNHLQEE----LERLREEQSR--TAPVADPKTLDSVTELASEVSQLNTIKEH 907
Query: 674 LKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSN 733
L++ I + N +L + Q + K++ D + + +++N Q + +
Sbjct: 908 LEEEIKHHQKIIEDQNQSKMQLLQSLQEQ----KKEMDEFRY-QHEQMNATHTQLFLEKD 962
Query: 734 EIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKATLLLESRP 793
E +K L K + H E + D + +E +L +EK L
Sbjct: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNS---DIFQETKVQSLNIENGSEKHDLSKAETE 1019
Query: 794 DLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQK-GELVHFVQTNSFSKPHDELKLS 852
L+K ++E L L E+ +S L + ++ K + G+L +Q E++ +
Sbjct: 1020 RLVKGIKERELEIKLLNEKNIS---LTKQIDQLSKDEVGKLTQIIQQKDL-----EIQ-A 1070
Query: 853 CEAQLVKAGEVPKVGLKDASVQTVATEGD-LLRFKHEATREAWEEKPINTALSAEHRPEN 911
A++ V +Q A E + + +E TRE N+ L E+ +
Sbjct: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRE-------NSHLKTEYH-KM 1122
Query: 912 LHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILEL 971
+ V +AAL+ L E KK + + S +M+R E + L I E
Sbjct: 1123 MDIVAAKEAALIKL----QDENKK----LSTRFESSGQDMFR-----ETIQNLSRIIREK 1169
Query: 972 QGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTS 1031
E+ L QK AV++ T ++ Q+ ++ +K
Sbjct: 1170 DIEI-------DALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKME 1222
Query: 1032 SVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAK 1091
W+ + M + Q +E ++ L + S + +
Sbjct: 1223 E-WKQQVMTTVQNMQHE-----------------SAQLQEELHQLQAQVLVDSDNNSKLQ 1264
Query: 1092 VSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE 1151
V G QS N ET+L+ + + Q+Q HS I LC T+
Sbjct: 1265 VDYTGLIQSYEQN---------------ETKLKNFGQELAQVQ-HS------IGQLCNTK 1302
Query: 1152 ----GAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLE 1207
G D +S S +T S +R K ++L + E++ LE L++ L+
Sbjct: 1303 DLLLGKLDIISPQL--SSASLLTPQSAECLRASKS-EVLSE-SSELLQQE-LEELRKSLQ 1357
Query: 1208 EQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGIC 1267
E++ ++ Q N H L + S L + + + + +Q+K+ +
Sbjct: 1358 EKDATIRTLQENN-------HRLSDSIAATS-----ELERKEHEQTDSEIKQLKEKQDVL 1405
Query: 1268 VISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMN 1327
+ + +IKA + L +S+ ++ E L Q L+ E++ + +G
Sbjct: 1406 QKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLK--ERILILEMDIGKLKG 1463
Query: 1328 TQNELMERIEEDNLTYQHLLPESPEPSASHALSDYE---TSEKSFFSRD---QKQDNETE 1381
+++E YQ L + + S ++E EK+ +K+ +T
Sbjct: 1464 ENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTG 1523
Query: 1382 KTSVMVNSFS--QDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFA 1439
+ + ++N+ Q+ + QE + L++ N L+ +++R + F
Sbjct: 1524 ELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFR 1576
Query: 1440 SGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDK--QKENDKLRESLSRKTVSLEHLQRE 1497
S EL H L ++ L R+ +K+ L E L + ++E+ +
Sbjct: 1577 SNQELERLRN---HLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQ 1633
Query: 1498 YASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSL 1557
ASV+ E+ + Q K+R L +LS QE+VK L+ +L+
Sbjct: 1634 -ASVQVESLQEQLNVVSKQRDETAL---------QLSVSQEQVKQYALSLANLQMVLEHF 1683
Query: 1558 RVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQS 1617
+ E KA + E ++ A WK +L ++ +Q + +++++S L
Sbjct: 1684 QQEEKAMYSAELEKQKQLIAE---WKKN--AENLEGKVISLQECLDEANAALDSASRLTE 1738
Query: 1618 RLK------EQLARGAEKAQE 1632
+L E+L R E QE
Sbjct: 1739 QLDVKEEQIEELKRQNELRQE 1759
Score = 98.6 bits (244), Expect = 5e-20
Identities = 350/1698 (20%), Positives = 658/1698 (38%), Gaps = 300/1698 (17%)
Query: 43 LLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQ-QEFHGPTEHI-Y 100
+L +EE + K+ E L+ EN LK LEE+ + E + Y
Sbjct: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSY 96
Query: 101 KTNIELK-VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL 159
+ ++ K VE+ LK + L+K A +S+ G +
Sbjct: 97 RNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSA 156
Query: 160 LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEK 219
+ D+ ++Q E+ + RLES++ + H + A D
Sbjct: 157 FHDDDMDFG-DIISSQQEINRLSNEVS-------RLESEVGHWR--HIAQTSKAQGTDNS 206
Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM 279
D+ E KL + +I+ LK+ +SQ ++ S +++ TE ++
Sbjct: 207 DQS-EICKL-----QNIIKELKQNRSQEIDDHQHEMS-------VLQNAHQQKLTEISR- 252
Query: 280 EHQKERNSFEERIQALEEDLREK-EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELN 338
H++E + +EERI+ LE L++ I T+ + K IQ L + KK+E+L
Sbjct: 253 RHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLE 312
Query: 339 SEIEKLSAAFAKA---REALQKAQTQ----EFQGSEDYETALSGKEALSAALRSQNLTKS 391
+I+ ++ + A R+ L++ Q Q + Q E+ E L + Q+ T +
Sbjct: 313 DKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMT 372
Query: 392 TENHRLRRS-----IKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKL 446
+ L +S + ++ Q LSD + E RL +++ S + ++ K+
Sbjct: 373 EKERILAQSASVEEVFRLQQALSDAENEIMRLSS----LNQDNSLAEDNLK------LKM 422
Query: 447 RNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQ------------ 494
R EV E+EK++ ++ K L S KL+N+ +VIK ST +D+ L
Sbjct: 423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK----STATRDISLDSELHDLRLNLEA 478
Query: 495 KFNEKDLEVIQQNCYLMAAEDLELRSEG------LITEKCSSQQPPGSKTIFSKEKKQSS 548
K E + + ++ + E+L+ +++ LI ++ S QQ G +I SK K+ +
Sbjct: 479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGD-SIISKLKQDLN 537
Query: 549 DYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTL 608
D ++ + L+ ++ D L + K+ L L+ Q L +
Sbjct: 538 DEKKRVHQLEDDK------------MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
Query: 609 EEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELY 668
E + ++ + +E + S+ + L+E+ R ++EEL + ++L+Q + +
Sbjct: 586 ENLVDQLNKSQESNVSIQKENLE-----LKEHIRQ-----NEEELSRIRNELMQSLNQDS 635
Query: 669 TDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQH 728
N F D L + E+ K++ ++ ++ D
Sbjct: 636 NSN-------------------FKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
Query: 729 LQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNE-KATL 787
++ ++ C++ +RH ++ +C + LE+ + L E +A L
Sbjct: 677 MENEKLVL------ACED--VRH---QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
Query: 788 ------LLESRPDLLKVVRELLLGQLFLTEQ-EVSGEHLDGKTEKTPKQKGELVHFVQT- 839
LLE K + EL + T ++ EHL +K + EL ++
Sbjct: 726 CWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQM 785
Query: 840 -NSFSKPHDELKLSCE-----AQLVKAGEVPKVGLKDAS--VQTVATEGDLLRFKHEATR 891
+ D L S E QL+ E+ LK+ S +Q + K+E R
Sbjct: 786 DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILR 845
Query: 892 EAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNM 951
+ EEK + E EN H Q L L RE + P+
Sbjct: 846 QTIEEKDRSLGSMKE---ENNH----LQEELERL-----REEQSRTAPVAD--------- 884
Query: 952 YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLI---------LAEAVMEGRPTP 1002
P T + VT+L S++ +L +KE + HQK+I L +++ E +
Sbjct: 885 ---PKTLDSVTELASEVSQLN-TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEM 940
Query: 1003 DKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASL 1062
D+ YQ + T + +D+E+ S Q+ +I +++
Sbjct: 941 DEF----------RYQHE--QMNATHTQLFLEKDEEIKSLQKTIEQIKTQL--------- 979
Query: 1063 PSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETE 1122
E +D+ + S + +K Q +++ + ++ + ETE L + I + E E
Sbjct: 980 ---HEERQDIQTDNS-DIFQETKVQ---SLNIENGSEKHDLSKA-ETERLVKGIKERELE 1031
Query: 1123 LEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKH 1182
++ L K D LSK + G L Q+ K
Sbjct: 1032 IKLLNEKNISLTKQI-----------------DQLSKDEVGK---------LTQIIQQKD 1065
Query: 1183 VKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQ-----NLNMQLFSEIHNLQNKFRDL 1237
++I A S + + Q + Q Y +++E+ N + S + +K D+
Sbjct: 1066 LEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDI 1125
Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKA-----------FEELLQ 1286
+ +L++ Q L + G + + Q+++ +I+ + LL
Sbjct: 1126 VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLA 1185
Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVG--------VEMNTQNELMERIEE 1338
E NQ ELL++ +KL K + N Q+E + EE
Sbjct: 1186 VLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
Query: 1339 DNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQ-----D 1393
+ +L +S S DY +S+ + K N ++ + + +S Q D
Sbjct: 1246 LHQLQAQVLVDSDNNSKLQV--DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKD 1303
Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS-IFASGSELHSSLTSEI 1452
LL+ + + I L Q +E ++ S S + + SEL L E+
Sbjct: 1304 LLLGKL-----------DIISPQLSSASLLTPQSAECLRASKSEVLSESSEL---LQQEL 1349
Query: 1453 HFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS-----VKEENER 1507
LRK Q +A + R Q+ N +L +S++ T LE + E +KE+ +
Sbjct: 1350 EELRKSLQEKDATI----RTLQENNHRLSDSIAA-TSELERKEHEQTDSEIKQLKEKQDV 1404
Query: 1508 LQKEGSEKERHNQQLIQEVRCSGQEL-SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEK 1566
LQK EK+ + ++ S + ++V E LRQ + + +++L L +++ K
Sbjct: 1405 LQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL-ILEMDI---GK 1460
Query: 1567 LDEEHRRLREASGEGWKGQD-PFRDLHSLLMEIQALRLQLERSIETSSTLQSRLK-EQLA 1624
L E+ ++ E ++G++ ++ L M+ + E+ E S + L EQL
Sbjct: 1461 LKGENEKIVET----YRGKETEYQALQETNMKFS--MMLREKEFECHSMKEKALAFEQLL 1514
Query: 1625 RGAEKAQEGALTLAVQAV 1642
+ E+ + G L + AV
Sbjct: 1515 KEKEQGKTGELNQLLNAV 1532
Score = 74.7 bits (182), Expect = 8e-13
Identities = 143/767 (18%), Positives = 312/767 (40%), Gaps = 146/767 (19%)
Query: 50 ETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT------N 103
E ++ T + + + +I L+K +K +++ EER Q+ I++ N
Sbjct: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH--EER--QDIQTDNSDIFQETKVQSLN 1003
Query: 104 IE--------LKVEVESLKRELQERE---QLL----IKASKAVESLAEAGGSEIQRVKED 148
IE K E E L + ++ERE +LL I +K ++ L++ ++ ++ +
Sbjct: 1004 IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQ 1063
Query: 149 ARKKVQQVEDLL-----TKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK 203
++Q + + T+ ++ L++ + A E EK FA + L+++ +M
Sbjct: 1064 KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM 1123
Query: 204 KMHEG-DLAMALVLDEKDRL---------------IEELKLSLKSKEALIQCLKEEKSQM 247
+ + A+ + DE +L I+ L ++ K+ I L ++ +
Sbjct: 1124 DIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTL 1183
Query: 248 ACPDENVSSG-ELRGLCAAPREE--KERET---EAAQMEHQKER-----NSFEERIQALE 296
+ S+G E G+ + EE +ER+ + +ME K++ + + L+
Sbjct: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243
Query: 297 EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
E+L + + ++ + N+ K GL + + E K++ E+ ++ + Q
Sbjct: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIG------Q 1297
Query: 357 KAQTQEFQGSEDYETALSGK-EALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQER 415
T++ L GK + +S L S +L LR S ++ E S+L
Sbjct: 1298 LCNTKDL---------LLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL---- 1344
Query: 416 ERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQ 475
L+++LEE + + D TIR L+ +L + + + SE +K H Q
Sbjct: 1345 --LQQELEELRKSLQEKDATIRTLQENNHRLSDSI------------AATSELERKEHEQ 1390
Query: 476 -EQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAED----------------LEL 518
+ IK L E ++DVL + EKDL + ++ L+++ + L
Sbjct: 1391 TDSEIKQLKE---KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL 1447
Query: 519 RSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEEL------IQVLKKEQDIYTHLVKS-- 570
+ LI E + ++ I + + ++Y+ L ++ +E++ H +K
Sbjct: 1448 KERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKA 1507
Query: 571 ------LQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR---------KTLEEQI--S 613
L+E + ELN++ K +++ + +Q R K +E +
Sbjct: 1508 LAFEQLLKEKE--QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
Query: 614 EIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQH 673
E++R ++ F + + LE + + E + E+ + K+ + +++E + +
Sbjct: 1566 EVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSN 1625
Query: 674 LKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
+ + + + + EQ +++ + DE +++ E
Sbjct: 1626 AMENASHQASVQVE--------SLQEQLNVVSKQRDETALQLSVSQE 1664
Score = 44.7 bits (104), Expect = 9e-04
Identities = 160/843 (18%), Positives = 308/843 (36%), Gaps = 182/843 (21%)
Query: 954 LPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPV 1013
L A ++ + Q S+ L E++E N++ + +IL + + + ++++
Sbjct: 476 LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK-- 533
Query: 1014 GAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVL 1073
QD E+K + D + D Q+ I SE+ L L K+ ED +
Sbjct: 534 ----QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVA----LNDLHLTKQKLEDKV 585
Query: 1074 SPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQL 1133
V + Q +++ E LK+ I E EL +N + Q
Sbjct: 586 ENL---------------VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS 630
Query: 1134 QKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFS-----------------SLHQ 1176
S T+L E L + N S+ E++ + +
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQ--NLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 1177 VRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEY-------KLQKEQNLNMQLFSEIHN 1229
VR+ + G + + ++E LK + E E +L +E N + E+ N
Sbjct: 689 VRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSN 748
Query: 1230 LQNKFRDLSPPRYDSLV---QSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
+N ++ L+ Q + E++ ++ I+ ++ +++ ++ ++L Q
Sbjct: 749 ARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQ 808
Query: 1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK--------------SVGVEMNTQNEL 1332
+ E +E+ ++ E L+K + + S+ E N E
Sbjct: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Query: 1333 MERIEEDN---------------------LTYQHLLPESPEPSASH---ALSDYETSEKS 1368
+ER+ E+ ++ + + E E H + D S+
Sbjct: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
Query: 1369 FFSRDQKQDNETEKTSVM---VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLER 1425
Q+Q E ++ +N+ L +E +EI++L+K +E+ + R+ ++
Sbjct: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQT 988
Query: 1426 QGSEFVQGS---TSIFASGSELHSSLTSE--------------IHFLRKQNQALNAMLIK 1468
S+ Q + + +GSE H +E I L ++N +L + +
Sbjct: 989 DNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQ 1048
Query: 1469 GSRDK---------QKEND----KLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEK 1515
S+D+ QK+ + R S + T + +LQ++ + E E++ +EK
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEK 1108
Query: 1516 ERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLR 1575
R N L E K++ + + A KL +E+++L
Sbjct: 1109 TRENSHLKTEYH------------------------KMMDIVAAKEAALIKLQDENKKLS 1144
Query: 1576 EASGEGWKGQDPFRDLHSLL--------MEIQALRLQ---LERSIETSST---------- 1614
GQD FR+ L +EI AL + L ++TSST
Sbjct: 1145 TRFES--SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSN 1202
Query: 1615 -----LQSR--LKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHD-GDKYPMESDNS 1666
LQ R LK+Q+ + E Q+ T VQ + LQ + H + ++SDN+
Sbjct: 1203 QFEELLQERDKLKQQVKKMEEWKQQVMTT--VQNMQHESAQLQEELHQLQAQVLVDSDNN 1260
Query: 1667 FDL 1669
L
Sbjct: 1261 SKL 1263
Score = 31.6 bits (70), Expect = 7.7
Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 7/108 (6%)
Query: 44 LPNVSEETVSPTRARNMKDFENQ---ITELKKENFNLKLRIYFLEERMQQEFHGPTEHIY 100
L V E +A + E Q I E KK NL+ ++ L+E + E + +
Sbjct: 1676 LQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLD-EANAALDSAS 1734
Query: 101 KTNIELKV---EVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRV 145
+ +L V ++E LKR+ + R+++L K + SLA + ++ +V
Sbjct: 1735 RLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 98.6 bits (244), Expect = 5e-20
Identities = 137/611 (22%), Positives = 261/611 (42%), Gaps = 71/611 (11%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
EE V+ A + E++ TELKK+ +LKL + E+ Q TE+ K E
Sbjct: 978 EEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQ-----ATENKVKNLTEEMA 1032
Query: 109 EVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDL--LTKRILL 166
++ L + ++ L +A + +A + + + + QQVEDL ++
Sbjct: 1033 ALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKK 1092
Query: 167 LEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLI--- 223
L D A+ +LE T+ A + + +L E K + +L+ + E ++L+
Sbjct: 1093 LRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQ 1152
Query: 224 ------------EELKLSLKSKEALIQCLKEEKSQMACPDENVSS--GELRGLCAAPREE 269
EEL+ L+++ A +++++++ A E +S E G A RE
Sbjct: 1153 MQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREG 1212
Query: 270 -KERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328
++RE E ++ + E + R +A LR K+ E A E + + L +
Sbjct: 1213 CRKREAELGRLRRELEEAAL--RHEATVAALRRKQAEGAAE------LGEQVDSLQRVRQ 1264
Query: 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNL 388
EK+ EL E++ L+A E L +A+ + YE LS + L+ Q
Sbjct: 1265 KLEKEKSELRMEVDDLAANV----ETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 389 TKSTENHRLRRSIKKITQELSDLQ--------------QERERLEKDLEEAHREKSKGDC 434
ST+ RL+ ++++ L + + Q E L + LEE + KS
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 435 TIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN-----QEQVIKHLTESTNQK 489
++ LR++ + LR E +E E + + LLS++N ++ + I+ E K
Sbjct: 1381 AVQALRHDCDLLR-EQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAK 1439
Query: 490 DVLLQKFNEKD--LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
L + E + +E C + L L++E +E + + + + +KKQ
Sbjct: 1440 KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE---SEDVTLELERATSAAAALDKKQR 1496
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLR-- 605
L + ++E+++ L + +ES + ++F LR E+ + + + L+
Sbjct: 1497 HLERALEERRRQEEEMQRELEAAQRESRGLG------TELFRLRHGHEEALEALETLKRE 1550
Query: 606 -KTLEEQISEI 615
K L+E+IS++
Sbjct: 1551 NKNLQEEISDL 1561
Score = 87.4 bits (215), Expect = 1e-16
Identities = 157/690 (22%), Positives = 290/690 (42%), Gaps = 96/690 (13%)
Query: 43 LLPNVSEETVSPTRARNM-KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYK 101
L NV T + A + + +E+Q++E K + +EE +Q T+
Sbjct: 1280 LAANVETLTRAKASAEKLCRTYEDQLSEAKIK----------VEELQRQLADASTQRG-- 1327
Query: 102 TNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKK----VQQVE 157
L+ E L R L+E+E L+ + S+ ++LA E++R E+ K V+
Sbjct: 1328 ---RLQTESGELSRLLEEKECLISQLSRG-KALAAQSLEELRRQLEEESKAKSALAHAVQ 1383
Query: 158 DLLTKRILLLEK--DVTAAQAELEKAFAGTETEKAL-RLRLESK-LSEMKKMHEGDLAMA 213
L LL E+ + AQAEL++ + E A R + E+ + +++ E +A
Sbjct: 1384 ALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLA 1443
Query: 214 LVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGEL----------RGLC 263
L L E + +E S E L+ E + E +S R L
Sbjct: 1444 LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE 1503
Query: 264 AAPREEKE--RETEAAQMEHQ-------KERNSFEERIQALEEDLREK---EREIATEKK 311
R+E+E RE EAAQ E + + R+ EE ++ALE RE + EI+
Sbjct: 1504 ERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD 1563
Query: 312 NSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYET 371
K+IQ L K+ E + E+ + +E+ A + Q + Q + +
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623
Query: 372 ALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEE------- 424
L+ K+ A LR +N ++ E+ L+ S+ T+ ++ + ++++E DL +
Sbjct: 1624 KLAEKDEECANLR-RNHQRAVES--LQASLDAETRARNEALRLKKKMEGDLNDLELQLGH 1680
Query: 425 AHREKSKGDCTIRDL----------RNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHN 474
A R+ ++ R + R+E ++L E++E+ +A+E R L +E +
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAA 1740
Query: 475 QEQ-------VIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEK 527
EQ + L E+T + ++L + ++ ++ Q L A DL S G + E
Sbjct: 1741 LEQGERSRRLAEQELLEATERLNLL----HSQNTGLLNQKKKLEA--DLAQLS-GEVEEA 1793
Query: 528 CSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE-SDSINNLQAELNK 586
++ K KK +D + + LKKEQD HL + + ++ LQA L
Sbjct: 1794 AQERREAEEKA-----KKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLE- 1847
Query: 587 IFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVE 646
E + + + +K +++ +++R E E + L + R +
Sbjct: 1848 --------EAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKEL 1899
Query: 647 HFSQEELKKKVSDLIQLVKELYTDNQHLKK 676
+ EE +K ++ + LV +L + + K+
Sbjct: 1900 AYQAEEDRKNLARMQDLVDKLQSKVKSYKR 1929
Score = 75.5 bits (184), Expect = 5e-13
Identities = 142/637 (22%), Positives = 262/637 (41%), Gaps = 89/637 (13%)
Query: 69 ELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQE--------- 119
+++K+ L+ R LEE ++ E + K E E+E L L+E
Sbjct: 1152 QMQKKIKELQARAEELEEELEAE-RAARARVEKQRAEAARELEELSERLEEAGGASAGQR 1210
Query: 120 -----REQLLIKASKAVESLA---EAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDV 171
RE L + + +E A EA + ++R + + ++ + D L + LEK+
Sbjct: 1211 EGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEK 1270
Query: 172 TAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALV-LDEKDRLIEELKLS- 229
+ + E++ A ET R ++ ++ + +E L+ A + ++E R + +
Sbjct: 1271 SELRMEVDDLAANVET----LTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQR 1326
Query: 230 --LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNS 287
L+++ + L EEK C +S G + L A EE R+ E E K +++
Sbjct: 1327 GRLQTESGELSRLLEEKE---CLISQLSRG--KALAAQSLEELRRQLE----EESKAKSA 1377
Query: 288 FEERIQALEED---LREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKL 344
+QAL D LRE+ E A E + L+R L +V + S+ E
Sbjct: 1378 LAHAVQALRHDCDLLREQHEEEA-EAQAELQR---------LLSKANAEVAQWRSKYE-- 1425
Query: 345 SAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKI 404
A + E L++A+ + ++ E + A ++L L TE+ + +++
Sbjct: 1426 -ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERA 1484
Query: 405 TQELSDLQQERERLEKDLEEAHREKSKGDCTI-------RDLRNEVEKLRNEVNEREKAM 457
T + L +++ LE+ LEE R++ + + R L E+ +LR+ E +A+
Sbjct: 1485 TSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEAL 1544
Query: 458 ENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLE 517
E L NK N ++ I LT+ + +Q+ + + + + AA +
Sbjct: 1545 ET-----LKRENK---NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596
Query: 518 LRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSI 577
+ L K Q S+ ++K + EE + + Q V+SLQ S
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ----RAVESLQAS--- 1649
Query: 578 NNLQAEL---NKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFS---LYSDQTS 631
L AE N+ L+K++E D+ LE Q+ R+ E+ + L Q
Sbjct: 1650 --LDAETRARNEALRLKKKMEGDL-------NDLELQLGHATRQATEAQAATRLMQAQLK 1700
Query: 632 YLSICLEENNRFQVE-HFSQEELKKKVSDLIQLVKEL 667
+E R E H + L+++ S L ++EL
Sbjct: 1701 EEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737
Score = 75.1 bits (183), Expect = 6e-13
Identities = 124/565 (21%), Positives = 245/565 (43%), Gaps = 72/565 (12%)
Query: 226 LKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGL--CAAPREEKERETEAAQMEHQK 283
+KL K K L EE+ ELRGL A E K +E E + +
Sbjct: 879 MKLFFKMKPLLRSAQAEEELAAL-------RAELRGLRGALAAAEAKRQELEETHVSITQ 931
Query: 284 ERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEK 343
E+N ++QA +++L + E E+ + L + K + L+ K K++ E + E+
Sbjct: 932 EKNDLALQLQAEQDNLADAE-----ERCHLLIKSK------VQLEGKVKELSERLEDEEE 980
Query: 344 LSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403
++A A R L+ T+ + +D + L+ E A ++ + E L S+ +
Sbjct: 981 VNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR 1040
Query: 404 ITQELSDLQQERERLEKDLE-EAHREKSKGDCTIRDLRNEVEKLRNEVNEREK-AMENRY 461
+T+E LQ+ ++ DL+ E R + +R L +VE L + + +K M+
Sbjct: 1041 LTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLR-LEQQVEDLECSLEQEKKLRMDTER 1099
Query: 462 KSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQ-----QNCYLMAAE-- 514
E + KL QE V ++ K L +K +KD E+ Q ++ L+ A+
Sbjct: 1100 AKRKLEGDLKL-TQESV----ADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQ 1154
Query: 515 ----DLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKS 570
+L+ R+E L E+ +++ ++ + + + + + EEL + L++ +
Sbjct: 1155 KKIKELQARAEEL-EEELEAERAARAR-VEKQRAEAARELEELSERLEEAGGASAGQREG 1212
Query: 571 LQESDS-INNLQAELNK--------IFALRK-------QLEQDVLSYQNLRKTLEEQISE 614
++ ++ + L+ EL + + ALR+ +L + V S Q +R+ LE++ SE
Sbjct: 1213 CRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSE 1272
Query: 615 IRRREEESF----SLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTD 670
+R ++ +L + S +C ++ EEL+++++D L T+
Sbjct: 1273 LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTE 1332
Query: 671 NQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEI-------NF 723
+ L + + + C+ Q + LA+ EL E+E K + +
Sbjct: 1333 SGELSRLLEEKECLISQLSR-GKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 724 LSDQHLQQSN---EIMKDLSKGGCK 745
L +QH +++ E+ + LSK +
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAE 1416
Score = 53.1 bits (126), Expect = 2e-06
Identities = 124/590 (21%), Positives = 210/590 (35%), Gaps = 99/590 (16%)
Query: 1082 LSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELE-GYQNFIFQLQKHSQCS 1140
+ SK Q KV + + + + ++K+ D TEL+ + L K +
Sbjct: 958 IKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEK 1017
Query: 1141 EAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLE 1200
+A TE L++ D + + H + LG L E L
Sbjct: 1018 QA-------TENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070
Query: 1201 N----LKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQ 1256
L+QQ+E+ E L++E+ L M L+ + L Q + +
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLK---------LTQESVADAAQD 1121
Query: 1257 RQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLF 1316
+QQ+++ + K EL Q S EQL A++ +K+++L
Sbjct: 1122 KQQLEE-------------KLKKKDSELSQLS------LRVEDEQLLG-AQMQKKIKELQ 1161
Query: 1317 LNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376
+ + E+ + R+E+ L E E E S Q++
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSE----------RLEEAGGASAGQRE 1211
Query: 1377 DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS 1436
+ E+ LR+ LEE+ +E L R+ +E
Sbjct: 1212 GCRKREA-----------------ELGRLRRELEEAALRHEATVAALRRKQAEGAAELGE 1254
Query: 1437 IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLR---ESLSRKTVSLEH 1493
S + L E LR + L A + +R K R + LS + +E
Sbjct: 1255 QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314
Query: 1494 LQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSR-----VQEEVKLRQQLLS 1548
LQR+ A + RLQ E E R L++E C +LSR Q +LR+Q L
Sbjct: 1315 LQRQLADASTQRGRLQTESGELSR----LLEEKECLISQLSRGKALAAQSLEELRRQ-LE 1369
Query: 1549 QNDKLLQSLRVELKAY----EKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQ 1604
+ K +L ++A + L E+H EA E L LL + A Q
Sbjct: 1370 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAE----------LQRLLSKANAEVAQ 1419
Query: 1605 LERSIETSSTLQS----RLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQ 1650
E + ++ K++LA ++A+EG + S+ + L+
Sbjct: 1420 WRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Score = 51.2 bits (121), Expect = 9e-06
Identities = 77/325 (23%), Positives = 150/325 (46%), Gaps = 24/325 (7%)
Query: 62 DFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE 121
+ + ++ E +E NL+ E +Q T + + LK ++E +L+
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEA-LRLKKKMEGDLNDLEL-- 1676
Query: 122 QLLIKASKAVESLAEAGGSEIQRVKEDA-RKKVQQVEDLLTKRILLLEKDVTAAQAELEK 180
QL +A E+ A + Q +E A R + Q++ L ++ LE+ + AELE+
Sbjct: 1677 QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEE 1736
Query: 181 AFAGTET-EKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEEL-KLSLKSKEALIQ 238
A E E++ RL + L ++++ +L++K +L +L +LS + +EA +
Sbjct: 1737 LRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQE 1796
Query: 239 CLK-EEKSQMACPDENVSSGELRGL--CAAPREEKERETEAAQMEHQKERNSFEE----- 290
+ EEK++ A D + + EL+ +A E ++ E E Q E+
Sbjct: 1797 RREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG 1856
Query: 291 ---RIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAA 347
++Q LE +RE E E+ E+K K +A++G ++ E++V+EL + E+
Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQK---KHAEALKG----VRKHERRVKELAYQAEEDRKN 1909
Query: 348 FAKAREALQKAQTQEFQGSEDYETA 372
A+ ++ + K Q++ +E A
Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEEA 1934
Score = 50.1 bits (118), Expect = 2e-05
Identities = 68/324 (20%), Positives = 126/324 (38%), Gaps = 40/324 (12%)
Query: 55 TRARN------------MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKT 102
TRARN + D E Q+ ++ + ++ ++++E G E
Sbjct: 1654 TRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ--- 1710
Query: 103 NIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK 162
L E+ + L+ R LL + + + E G E +R+ +Q T+
Sbjct: 1711 --RLAAELHEQAQALERRASLLAAELEELRAALEQG--------ERSRRLAEQELLEATE 1760
Query: 163 RILLLEKDVTAA-----QAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLD 217
R+ LL T + E + A E E+A + R E++ K + + + +
Sbjct: 1761 RLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKK 1820
Query: 218 EKDRL--IEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETE 275
E+D +E +K +L+ +Q EE Q A +L E K RE E
Sbjct: 1821 EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKL--------EAKVRELE 1872
Query: 276 AAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVE 335
A QK+ + ++ E ++E + ++KN + + L +KS +++ E
Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFE 1932
Query: 336 ELNSEIEKLSAAFAKAREALQKAQ 359
E + A + KA+ L A+
Sbjct: 1933 EAEQQANTNLAKYRKAQHELDDAE 1956
Score = 44.7 bits (104), Expect = 9e-04
Identities = 137/732 (18%), Positives = 282/732 (38%), Gaps = 101/732 (13%)
Query: 953 RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPP 1012
R+ Q + Q+Q +I ELQ +E + ++L + V + R + L
Sbjct: 1142 RVEDEQLLGAQMQKKIKELQARAEELE---EELEAERAARARVEKQRAEAARELEELSER 1198
Query: 1013 VGAAYQDSPGEQKGIK---------------------TTSSVWRDKEMDSDQQRSYEIDS 1051
+ A S G+++G + T + R K+ + + ++DS
Sbjct: 1199 LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDS 1258
Query: 1052 EICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSN-ETE 1110
L KE E + +A + + ++ A + + ++ + + E
Sbjct: 1259 LQRVRQKLE-----KEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVE 1313
Query: 1111 YLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLC-GTEGAQDGLSKPKNGSDGEEM 1169
L++++ D T+ Q +L + + E +I+ L G A L + + + E
Sbjct: 1314 ELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESK 1373
Query: 1170 TFSSL-HQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIH 1228
S+L H V+ ++H L L++Q EE+ + Q L + +E+
Sbjct: 1374 AKSALAHAVQALRHDCDL---------------LREQHEEEAEAQAELQRLLSKANAEVA 1418
Query: 1229 NLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDG----HGICV-ISRQHMNTMIKAFEE 1283
++K+ + R + L +++ ++L+L+ Q+ ++G + C + + + ++ +
Sbjct: 1419 QWRSKYEADAIQRTEELEEAK-KKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477
Query: 1284 LLQASDVDYCVA----------EGFQEQLNQCAELLEKLEKLFLNGKSVGVEM----NTQ 1329
L+ A +E+ Q E+ +LE + +G E+ +
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGH 1537
Query: 1330 NELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNS 1389
E +E +E ++L E + + +LS E K+ E EK+ +
Sbjct: 1538 EEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELE----KTKKALEGEKSEIQAAL 1593
Query: 1390 FSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLT 1449
+ +E ++E +TLR +LE S + ++ ++L + E + + L +SL
Sbjct: 1594 EEAEGALE-LEETKTLRIQLELS-QVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLD 1651
Query: 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQ 1509
+E R +N+AL K+ E D L+ + L H R+ + +Q
Sbjct: 1652 AET---RARNEALRLK-------KKMEGD-----LNDLELQLGHATRQATEAQAATRLMQ 1696
Query: 1510 KEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDE 1569
+ ++E + E R+ E+ + Q L + LL + EL+A + E
Sbjct: 1697 AQ-----------LKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGE 1745
Query: 1570 EHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEK 1629
RRL E E + + LHS + + +LE + S ++ EK
Sbjct: 1746 RSRRLAEQ--ELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEK 1803
Query: 1630 AQEGALTLAVQA 1641
A++ A+ A
Sbjct: 1804 AKKAITDAAMMA 1815
Score = 42.4 bits (98), Expect = 0.004
Identities = 96/450 (21%), Positives = 180/450 (40%), Gaps = 59/450 (13%)
Query: 1332 LMERIEEDNLTYQ----HLLPESPEP------SASHALSDYETSEKSFFSRDQKQDNETE 1381
L + E+DNL HLL +S S L D E +R +K ++E
Sbjct: 938 LQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECT 997
Query: 1382 KTSVMVNSFSQDLLMEHIQEIRTLRK---------RLEESIKTNEKLRKQLERQGSEFVQ 1432
+ ++ L ++ T K L+ES+ K +K L+ E Q
Sbjct: 998 ELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ----EAHQ 1053
Query: 1433 GSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLE 1492
+ + + S+LT L +Q + L L ++ KLR R LE
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVEDLECSL--------EQEKKLRMDTERAKRKLE 1105
Query: 1493 H----LQREYASVKEENERLQKEGSEKERHNQQL---IQEVRCSGQELSRVQEEVKLRQQ 1545
Q A ++ ++L+++ +K+ QL +++ + G ++ + +E++ R +
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165
Query: 1546 LLSQNDKLLQSLRVELK-----AYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQA 1600
L + + ++ R ++ A +L+E RL EA G ++ R + E+
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREA---ELGR 1222
Query: 1601 LRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYP 1660
LR +LE + + L+ + A EGA L Q S+ V + +K +
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQA-------EGAAELGEQVDSLQRVRQKLEKEKSE-LR 1274
Query: 1661 MESDNSFDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWA 1720
ME D DL + + +T ++ + L D LS ++ T
Sbjct: 1275 MEVD---DLAANVETLT-RAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ 1330
Query: 1721 SKNGRHVLGLIEDYEALLKQISQGQRLLAE 1750
+++G + L+E+ E L+ Q+S+G+ L A+
Sbjct: 1331 TESGE-LSRLLEEKECLISQLSRGKALAAQ 1359
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 98.2 bits (243), Expect = 7e-20
Identities = 146/647 (22%), Positives = 267/647 (41%), Gaps = 101/647 (15%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123
EN++TE++ L L+E++Q E EL E E L+ L ++Q
Sbjct: 865 ENRLTEMETLQSQLMAEKLQLQEQLQAE------------TELCAEAEELRARLTAKKQE 912
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183
L + +E+ E Q ++ + +K Q +++L + LE++ +A Q
Sbjct: 913 LEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ----LEEEESARQ-------- 960
Query: 184 GTETEKALRLRLESKLSE--MKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL- 240
+L+LE +E +KK+ E + + D+ +L +E KL L
Sbjct: 961 --------KLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 241 -KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDL 299
+EEKS+ +N + L EE+ R E + E +K R E L + +
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDL-----EERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 300 REKEREIATEKKNSLKRDKAIQGLTMALKSKE-------KKVEELNSEIEKLSAAFAKAR 352
E + +IA K K+++ +Q ++ + KK+ EL S+I +L R
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 353 EALQKAQTQEFQGSEDYETALSGKE------ALSAALRSQ-----NLTKSTENHRLRRSI 401
+ KA+ Q+ E+ E + E A LRS+ N+ K T +
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRY 461
+I + Q E L + LE+ R K+ + + L NE +L NEV
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV----------- 1233
Query: 462 KSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSE 521
K LL H +++V L E L KFNE + V + + +EL +
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQE-------LQVKFNEGE-RVRTELADKVTKLQVELDNV 1285
Query: 522 GLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQ 581
+ + S+ +K FS + Q D +EL+Q +++ L S + ++
Sbjct: 1286 TGLLSQSDSKSSKLTKD-FSALESQLQDTQELLQEENRQK---------LSLSTKLKQVE 1335
Query: 582 AELNKIFALRKQLEQDVLSYQNLRK---TLEEQISEIRRREEESFSLYSDQTSYLSICLE 638
E N + R+QLE++ + NL K TL Q+++++++ E+S +
Sbjct: 1336 DEKN---SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQK 1392
Query: 639 E----NNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDL 681
+ + R + + + ++L+K + L Q + +L D H +++ +L
Sbjct: 1393 DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Score = 79.7 bits (195), Expect = 2e-14
Identities = 121/616 (19%), Positives = 267/616 (43%), Gaps = 68/616 (11%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQL 123
+++ ++L K+ L+ ++ +E +Q+E K +++ E S + +L+E E+
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLK-QVEDEKNSFREQLEEEEEA 1351
Query: 124 LIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFA 183
K + +L A +++++ ED+ ++ E++ K L+KD+ E+ A
Sbjct: 1352 KHNLEKQIATL-HAQVADMKKKMEDSVGCLETAEEVKRK----LQKDLEGLSQRHEEKVA 1406
Query: 184 GTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEE 243
+ + + RL+ +L ++ + A L++K + ++L L EE
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL-------------LAEE 1453
Query: 244 KSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQ-KERNSFEERIQALEEDLREK 302
K+ +S+ A E +E+ET+A + +E + ++ L + R +
Sbjct: 1454 KT--------ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 303 EREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQE 362
++ + K + K++ L + ++ E++VEE+ +++E+L +A + +
Sbjct: 1506 MEDLMSSKDDV---GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562
Query: 363 FQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDL 422
+E L G++ S + Q L R ++++ EL D ER ++ +
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQ----------LVRQVREMEAELED-----ERKQRSM 1607
Query: 423 EEAHREKSKGDCTIRDLRNEVE---KLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVI 479
A R+K + D ++DL ++ K R+E ++ + ++ + K + E + ++E+++
Sbjct: 1608 AVAARKKLEMD--LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 480 KHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTI 539
E N+K K + E+IQ L AAE + +++ E K
Sbjct: 1666 AQAKE--NEK-----KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 540 FSKEKKQ--SSDYEELIQVLKKEQD----IYTHLVKSLQESDSINNLQAELNKIFALRKQ 593
+ E+K+ + +L + L++EQ I L K+ + D IN L + A + +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT-DLNLERSHAQKNE 1777
Query: 594 LEQDVLSYQN--LRKTLEEQISEIRRREEESFSLYSDQTSYLSICLE-ENNRFQVEHFSQ 650
+ L QN L+ L+E ++ + + S + + + L L+ E Q
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 651 EELKKKVSDLIQLVKE 666
+KK+ D++ V +
Sbjct: 1838 RRTEKKLKDVLLQVDD 1853
Score = 72.8 bits (177), Expect = 3e-12
Identities = 120/531 (22%), Positives = 215/531 (40%), Gaps = 89/531 (16%)
Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQAL 295
L+Q ++E+ MA +E V E + L A E + E E Q + E+ +E++QA
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVRE-KQLAA---ENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 296 EEDLREKE--REIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKARE 353
E E E R T KK L+ E +VEE + L A K ++
Sbjct: 893 TELCAEAEELRARLTAKKQELEE---------ICHDLEARVEEEEERCQHLQAEKKKMQQ 943
Query: 354 ALQ--KAQTQEFQGSED--------YETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403
+Q + Q +E + + E L E L QN + E L I +
Sbjct: 944 NIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE 1003
Query: 404 ITQELSDLQQERERLEK----------DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNER 453
T L++ +++ + L K DLEE R + K + R ++E +++++
Sbjct: 1004 FTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ 1063
Query: 454 EKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAA 513
++ + L + KK + + + E QK++ L+K E + ++ +
Sbjct: 1064 IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE------LQ 1117
Query: 514 EDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQE 573
EDLE +E+ S +K +KQ D E ++ LK E +
Sbjct: 1118 EDLE-------SERASR----------NKAEKQKRDLGEELEALKTELE----------- 1149
Query: 574 SDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYL 633
D++++ A+ LR + EQ+V L+KTLEE+ + +E +S L
Sbjct: 1150 -DTLDSTAAQQE----LRSKREQEV---NILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 634 SICLEENNRFQVE-HFSQEELKKKVSDLIQLVKELYT---DNQHLKKTIFDLSCMGFQGN 689
+ LE+ R + +++ L+ + +L VK L D++H +K + + Q
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV-EAQLQELQVK 1260
Query: 690 GFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLS 740
TE LA K + +++ D + L Q +S+++ KD S
Sbjct: 1261 FNEGERVRTE----LADKVTKLQVEL---DNVTGLLSQSDSKSSKLTKDFS 1304
Score = 72.8 bits (177), Expect = 3e-12
Identities = 104/462 (22%), Positives = 195/462 (42%), Gaps = 64/462 (13%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEH-IYKTNIELK 107
+ET + + AR +++ Q EL E N + R + ++ G + H + K+ L+
Sbjct: 1474 KETKALSLARALEEAMEQKAEL--ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 108 VEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLL 167
+VE +K +L+E E L +A E +Q +K + +Q ++ ++ L
Sbjct: 1532 QQVEEMKTQLEELEDEL----QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQL 1587
Query: 168 EKDVTAAQAELEKAFAGTETEKALRLRLESKLSEM--------KKMHEGDLAMALVLDEK 219
+ V +AELE A R +LE L ++ K E + + +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQM 279
+ EL + S+E ++ KE + ++ + + + L AA R +++ + E ++
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ-EELAAAERAKRQAQQERDEL 1706
Query: 280 EHQ------------KERNSFEERIQALEEDLREKE--REIATE--KKNSLKRDKAIQGL 323
+ +E+ E RI LEE+L E++ E+ + KK +L+ D+ L
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 324 TMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAAL 383
+ +S +K E ++E+ + +E K Q E Y+ +++ EA A L
Sbjct: 1767 NLE-RSHAQKNENARQQLERQN------KELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 384 RSQ--NLTKSTEN--HRLRRSIKKITQELSDLQQER-----------------ERLEKDL 422
Q N TK + ++RR+ KK+ L + ER ++L++ L
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQL 1879
Query: 423 EEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSL 464
EEA E + + + R L+ E+E + E AM SL
Sbjct: 1880 EEAEEEAQRANASRRKLQRELE----DATETADAMNREVSSL 1917
Score = 72.4 bits (176), Expect = 4e-12
Identities = 103/469 (21%), Positives = 201/469 (42%), Gaps = 88/469 (18%)
Query: 97 EHIYKTNIELKVEVESLKRELQEREQL---LIKASKAVESLAEAGGSEIQRVKEDARKKV 153
+ + KT L+ E++ L +L + Q L K K + L + + E+ +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 154 QQVEDLLTKRILLLE--KDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLA 211
+ + TK + L ++ +AELE+ TE + + SK K +HE + +
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTE--MEDLMSSKDDVGKSVHELEKS 1526
Query: 212 MALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSG---ELRGLCAAPRE 268
+ ++ +EE+K L+ E +Q ++ K ++ + + + +L+G E
Sbjct: 1527 KRAL----EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 269 EKE------RETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQG 322
+K+ RE EA + +K+R+ + LE DL++ E I + KN RD+AI+
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN---RDEAIKQ 1639
Query: 323 L------------------------TMALKSKEKKVEELNSEIEKLSAAFAKAREALQKA 358
L K EKK++ + +E+ +L A A A ++A
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 359 QTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERE-- 416
Q + + +++ + SGK AL+ E RL I ++ +EL + Q E
Sbjct: 1700 QQERDELADEIANS-SGKGALAL----------EEKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 417 --RLEK------------DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYK 462
RL+K +LE +H +K++ + L + ++L+ ++ E E ++++YK
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNEN--ARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 463 SLLSESNKKLHNQEQVIKHLTESTNQ------------KDVLLQKFNEK 499
+ ++ K+ E+ + + T+ KDVLLQ +E+
Sbjct: 1807 ASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855
Score = 66.6 bits (161), Expect = 2e-10
Identities = 128/672 (19%), Positives = 272/672 (40%), Gaps = 77/672 (11%)
Query: 1207 EEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGI 1266
EE+ K++++Q +E+ LQ+ Q A +L LQ +Q++ +
Sbjct: 851 EEELVKVREKQLAAENRLTEMETLQS--------------QLMAEKLQLQ-EQLQAETEL 895
Query: 1267 CVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEM 1326
C + + + +EL ++ + + +E+ +C L + +K+ N + + ++
Sbjct: 896 CAEAEELRARLTAKKQEL---EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 1327 NTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
+ ++++ + +T + L + E + + +++ D+ + T T
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 1387 VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHS 1446
S S L + + T LEE ++ EK R++LE+ + ST + +EL +
Sbjct: 1013 EKSKSLAKLKNKHEAMIT---DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 1447 SLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENE 1506
+ L K+ + L A L + + ++N L++ + L+ + + ++E+ E
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK--------IRELESQISELQEDLE 1121
Query: 1507 RLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDK----LLQSLRVELK 1562
+ ++ E+ + L +E+ EL + +Q+L S+ ++ L ++L E K
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 1563 AYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQ 1622
+E +E R+ K +L L + + ++ LE++ +T + L +
Sbjct: 1182 THEAQIQEMRQ---------KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 1623 ---LARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPK 1679
L +G ++ + Q LQ ++G++ E L D + +
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQE-----LQVKFNEGERVRTE------LADKVTKLQVE 1281
Query: 1680 SVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLK 1739
+ T LS +D+ S SA S+L L +N R L L LK
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALE----SQLQDTQELLQEEN-RQKLSL----STKLK 1332
Query: 1740 QISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL 1799
Q+ + E + +EA + +++ T A + K + T EE R+L+
Sbjct: 1333 QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ- 1391
Query: 1800 LWRVSLPEDGQCPLHCEQIG---EMKAEVTKLHKKLFEQEKKLQN-TMKLLQLSKRQEKV 1855
+G H E++ +++ T+L ++L + L + L K+Q+K
Sbjct: 1392 -----KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK- 1445
Query: 1856 IFDQLVVTHKIL 1867
FDQL+ K +
Sbjct: 1446 -FDQLLAEEKTI 1456
Score = 63.2 bits (152), Expect = 2e-09
Identities = 226/1187 (19%), Positives = 445/1187 (37%), Gaps = 191/1187 (16%)
Query: 440 RNEVEKLRNE-----VNEREKAMENRYKSLLSESNK----KLHNQEQVIKHLTESTNQKD 490
R E E + E V E++ A ENR + + ++ KL QEQ ++ TE + +
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ-LQAETELCAEAE 900
Query: 491 VLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDY 550
L + K E +++ C+ DLE R E E+C Q +++KK +
Sbjct: 901 ELRARLTAKKQE-LEEICH-----DLEARVEEE-EERCQHLQ--------AEKKKMQQNI 945
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEE 610
+EL + L++E+ L + + + +A+L K+ + LE +K LE+
Sbjct: 946 QELEEQLEEEESARQKL-----QLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 611 QISE----IRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKE 666
+I+E + EE+S SL + + ++ + R + E ++EL+K ++
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR-------RK 1052
Query: 667 LYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSD 726
L D+ L I +L E LA KE+E + +E
Sbjct: 1053 LEGDSTDLSDQIAELQAQ------------IAELKMQLAKKEEELQAALARVEE------ 1094
Query: 727 QHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPLFNEKAT 786
Q N +K + R ES+IS+ L+E + EK
Sbjct: 1095 -EAAQKNMALKKI----------RELESQISE---------LQEDLESERASRNKAEKQK 1134
Query: 787 LLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPH 846
L + LK E L ++ S + K ++ H Q + H
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 847 DELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLR-------------FKHEATREA 893
+ QL + V K L+ A G+L K +
Sbjct: 1195 SQAVEELAEQLEQTKRV-KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 894 WEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYR 953
+E + R E V Q L ++ G+ ++ KS L K +L + +
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK--LTKDFSALES--Q 1309
Query: 954 LPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPV 1013
L TQE++ + Q L L +LK+ + ++L E TL +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 1014 GAAYQDSPGEQKGIKTTSSVWR--DKEMDSDQQRSYEIDSEICPPDDLASLPS-CKENPE 1070
+DS G ++T V R K+++ QR E ++ D L + ++ +
Sbjct: 1370 KKKMEDSVG---CLETAEEVKRKLQKDLEGLSQRHEE---KVAAYDKLEKTKTRLQQELD 1423
Query: 1071 DVLSPTSVATYLSSKSQPSAKV--SVMGTDQSESINTSNETEYLKQKIHDLETEL----E 1124
D+L + + K ++ +++ S + E + + + + ET+
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLAR 1483
Query: 1125 GYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVK 1184
+ + Q + + ++ T + ++D + K S+H++ K
Sbjct: 1484 ALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK-------------SVHELEKSKRAL 1530
Query: 1185 ILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKF-RDL------ 1237
+ +E +K QLEE E +LQ ++ ++L + ++ +F RDL
Sbjct: 1531 -----------EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVA-- 1295
S + LV+ Q RE+ + + + + V +R+ + +K E + +++ + A
Sbjct: 1580 SEEKKKQLVR-QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638
Query: 1296 --EGFQEQLNQCA-----------ELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLT 1342
Q Q+ C E+L + ++ KS+ EM E + E
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698
Query: 1343 YQHLLPESPEPSASH------ALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLM 1396
Q E + A+ AL + E +++ + E T ++ + + L
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 1397 EHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF------VQGS---------TSIFASG 1441
I +I T + NE R+QLERQ E ++G+ T++ A
Sbjct: 1759 --IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKI 1816
Query: 1442 SELHSSLTSE-------IHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHL 1494
++L L +E +R+ + L +L++ D+++ ++ ++ + + L+ L
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD-DERRNAEQYKDQADKASTRLKQL 1875
Query: 1495 QREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVK 1541
+R+ +EE +R + +R + + +E+S ++ +++
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 62.0 bits (149), Expect = 5e-09
Identities = 78/402 (19%), Positives = 176/402 (43%), Gaps = 35/402 (8%)
Query: 60 MKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQ- 118
+++ E+++ + L++ + ++ + +++ G E + +L +V ++ EL+
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 119 EREQ--LLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK-RILLLEKDVTAAQ 175
ER+Q + + A K +E + + I ++ + ++Q+ L + + + E D T A
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELK-------L 228
E E E EK L+ + +++ + A E+D L +E+ L
Sbjct: 1661 RE-EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGAL 1719
Query: 229 SLKSK---EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQME-HQKE 284
+L+ K EA I L+EE + E ++ + + + E + + ++
Sbjct: 1720 ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA 1779
Query: 285 RNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEE-LNSEIEK 343
R E + + L+ L+E E + ++ K S+ AL++K ++EE L++E ++
Sbjct: 1780 RQQLERQNKELKVKLQEMEGTVKSKYKASIT----------ALEAKIAQLEEQLDNETKE 1829
Query: 344 LSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKK 403
AA + R +K + Q ++ A K+ A ST +L+R +++
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA--------STRLKQLKRQLEE 1881
Query: 404 ITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEK 445
+E R +L+++LE+A + + L+N++ +
Sbjct: 1882 AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 57.0 bits (136), Expect = 2e-07
Identities = 95/443 (21%), Positives = 180/443 (40%), Gaps = 61/443 (13%)
Query: 1196 SRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSL 1255
S+ +E L +QLE+ + + L +E L N+ + L + DS + + E L
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254
Query: 1256 QRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKL 1315
Q Q+K G + + T + LQ + L+Q KL K
Sbjct: 1255 QELQVKFNEG------ERVRTELADKVTKLQVE------LDNVTGLLSQSDSKSSKLTKD 1302
Query: 1316 FLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQK 1375
F ++ ++ EL++ L S S L E + SF R+Q
Sbjct: 1303 F---SALESQLQDTQELLQEENRQKL------------SLSTKLKQVEDEKNSF--REQL 1345
Query: 1376 QDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESI---KTNEKLRKQLERQGSEFVQ 1432
++ E K ++ + + H Q + ++K++E+S+ +T E+++++L++ Q
Sbjct: 1346 EEEEEAK-----HNLEKQIATLHAQ-VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Query: 1433 GSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQK--ENDKLRESLSRKTVS 1490
A+ +L + T + Q L+ +L+ +Q +K ++ +
Sbjct: 1400 RHEEKVAAYDKLEKTKT-------RLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE 1452
Query: 1491 LEHLQREYASVKEENERLQKEGSEKERHNQQL---IQEVRCSGQELSRVQEEVKLRQQ-L 1546
+ + +YA EE +R + E EKE L ++E EL R+ ++ + + L
Sbjct: 1453 EKTISAKYA---EERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 1547 LSQND---KLLQSLRVELKAYEKLDEEHR-RLREASGEGWKGQDPFRDLHSLLMEIQALR 1602
+S D K + L +A E+ EE + +L E E +D L + +QA++
Sbjct: 1510 MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE---VNLQAMK 1566
Query: 1603 LQLERSIETSSTLQSRLKEQLAR 1625
Q ER ++ K+QL R
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVR 1589
Score = 54.7 bits (130), Expect = 8e-07
Identities = 176/831 (21%), Positives = 312/831 (37%), Gaps = 155/831 (18%)
Query: 811 EQEVSGEHLDGKTEKTPKQKGELVHFVQTNSFSKPHDEL-KLSCEAQLVKAGEVPKVGLK 869
E+E +HL + +K + EL ++ ++ +L K++ EA+L K E ++ L+
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE-EQIILE 984
Query: 870 DASVQTVATEGDLLRFK-HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGI 928
D + + +A E LL + E T EE+ + +L+ + +N H +A + L
Sbjct: 985 DQNCK-LAKEKKLLEDRIAEFTTNLTEEEEKSKSLA---KLKNKH-----EAMITDLEER 1035
Query: 929 TNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQK 988
RE K+ + L K R L + T L QI ELQ ++ E K + ++
Sbjct: 1036 LRREEKQRQE--LEKTRRKL---------EGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084
Query: 989 LILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYE 1048
L A A +E L K I+ S + + D + +R+
Sbjct: 1085 LQAALARVEEEAAQKNMAL-----------------KKIRELESQISELQEDLESERASR 1127
Query: 1049 IDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNE 1108
+E D L + K ED L T+ L SK + + +N +
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE-------------QEVNILKK 1174
Query: 1109 TEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEE 1168
T + K H+ + + QKHSQ E + L T+ + L K K + E
Sbjct: 1175 TLEEEAKTHEAQIQE--------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 1169 MTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIH 1228
++ VK+L L + + ++ QL+E + K + + + +L ++
Sbjct: 1227 GELAN--------EVKVL--LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276
Query: 1229 NLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQAS 1288
LQ + +++ G+ S + + K F L
Sbjct: 1277 KLQVELDNVT--------------------------GLLSQSDSKSSKLTKDFSAL---- 1306
Query: 1289 DVDYCVAEGFQEQLNQCAELL--EKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHL 1346
+ QL ELL E +KL L+ K VE + +N E++EE+ +L
Sbjct: 1307 ----------ESQLQDTQELLQEENRQKLSLSTKLKQVE-DEKNSFREQLEEEEEAKHNL 1355
Query: 1347 LPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLR 1406
+ A A D K+ E SV ++++ + +++ L
Sbjct: 1356 EKQIATLHAQVA--------------DMKKKMED---SVGCLETAEEVKRKLQKDLEGLS 1398
Query: 1407 KRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQAL---N 1463
+R EE + +KL K R E + S + +K +Q L
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQEL----DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK 1454
Query: 1464 AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEG--------SEK 1515
+ K + ++ + + RE K +SL E K E ERL K+ S K
Sbjct: 1455 TISAKYAEERDRAEAEAREK-ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSK 1513
Query: 1516 ERHNQQLIQEVRCSGQELSRVQEEVK-----LRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
+ + + E+ S + L + EE+K L +L + D L+ L V L+A + E
Sbjct: 1514 DDVGKS-VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR-LEVNLQAMKAQFER 1571
Query: 1571 HRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKE 1621
+ R+ E K Q R + + E++ R Q ++ L+ LK+
Sbjct: 1572 DLQGRDEQSEEKKKQ-LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Score = 53.5 bits (127), Expect = 2e-06
Identities = 107/547 (19%), Positives = 210/547 (38%), Gaps = 102/547 (18%)
Query: 1108 ETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGE 1167
E + ++Q I +LE +LE ++ +LQ +EA + L E
Sbjct: 937 EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL------------------EE 978
Query: 1168 EMTFSSLHQVRYVKHVKILGP--------LAPEMIDSRVLENLKQQLE----EQEYKLQK 1215
E + K K+L L E S+ L LK + E + E +L++
Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038
Query: 1216 EQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMN 1275
E+ +L L+ DLS D + + QA+ L+ Q K
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLS----DQIAELQAQIAELKMQLAKK------------- 1081
Query: 1276 TMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMER 1335
EE LQA+ E Q N + + +LE +EL E
Sbjct: 1082 ------EEELQAA---LARVEEEAAQKNMALKKIRELESQI-------------SELQED 1119
Query: 1336 IEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKT----SVMVNSFS 1391
+E + + +EK RD ++ E KT ++ +
Sbjct: 1120 LESER-------------------ASRNKAEKQ--KRDLGEELEALKTELEDTLDSTAAQ 1158
Query: 1392 QDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSE 1451
Q+L + QE+ L+K LEE KT+E +++ ++ S+ V+ + ++L
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218
Query: 1452 IHFLRKQNQALN---AMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERL 1508
L + L +L++G D + + K+ L V +R + ++ +L
Sbjct: 1219 KQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL 1278
Query: 1509 QKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLD 1568
Q E Q + ++ S ++ +++ Q+LL + ++ SL +LK E D
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE--D 1336
Query: 1569 EEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSI---ETSSTLQSRLKEQLAR 1625
E++ + E + + + +L ++ ++ ++E S+ ET+ ++ +L++ L
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 1626 GAEKAQE 1632
+++ +E
Sbjct: 1397 LSQRHEE 1403
Score = 51.6 bits (122), Expect = 7e-06
Identities = 76/446 (17%), Positives = 182/446 (40%), Gaps = 25/446 (5%)
Query: 1198 VLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQR 1257
+ +L+ ++EE+E + Q Q ++ I L+ + + R ++ E L++
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK 975
Query: 1258 QQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC-AELLEKLEKLF 1316
+ + I + N + ++LL+ ++ +E+ ++ A+L K E +
Sbjct: 976 LEEEQ------IILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 1317 LNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQ 1376
+ +E + E +R E + T + L +S + S A + +E +++
Sbjct: 1030 TD-----LEERLRREEKQRQELEK-TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 1377 DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTS 1436
+ + V + +++ ++ I+E+ + L+E +++ R + E+Q + + +
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143
Query: 1437 IFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQR 1496
+ + S ++ K+ Q +N + + + +++E + + ++E L
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203
Query: 1497 EYASVKEENERLQKEGSEKERHNQQLIQEVRC-----SGQELSRVQEEVKLRQQLLSQND 1551
+ K L+K E +L EV+ E R + E +L++ + N+
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263
Query: 1552 KLLQSLRVEL-----KAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLE 1606
+ +R EL K +LD L ++ + K F L S L + Q L +
Sbjct: 1264 G--ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321
Query: 1607 RSIETSSTLQSRLKEQLARGAEKAQE 1632
R + ST +++++ E+ +E
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEE 1347
Score = 45.4 bits (106), Expect = 5e-04
Identities = 63/259 (24%), Positives = 112/259 (43%), Gaps = 19/259 (7%)
Query: 1394 LLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIH 1453
LL QE + K EE +K EK + E + +E + + A +L L +E
Sbjct: 837 LLQVSRQEEEMMAKE-EELVKVREK-QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 1454 FLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGS 1513
L + + L A L ++ ++ L + + +HLQ E +++ + L+++
Sbjct: 895 -LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 1514 EKERHNQQLIQEVRCSGQELSRVQEE-VKLRQQ--LLSQNDKLLQSLRVELKAYEKLDEE 1570
E+E Q+L E + +L +++EE + L Q L++ KLL+ E L EE
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT--NLTEE 1011
Query: 1571 HRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLE---RSIETSST--------LQSRL 1619
+ + + K + DL L + R +LE R +E ST LQ+++
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 1620 KEQLARGAEKAQEGALTLA 1638
E + A+K +E LA
Sbjct: 1072 AELKMQLAKKEEELQAALA 1090
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 98.2 bits (243), Expect = 7e-20
Identities = 152/690 (22%), Positives = 295/690 (42%), Gaps = 105/690 (15%)
Query: 64 ENQITELKKENFNLKLRIYFLEERMQ---QEFHGPTEHIYKTNIEL-KVEVESLKRE--- 116
+ Q+ L++E+ +L ++ +E +Q Q H + L +++ E+ RE
Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768
Query: 117 -LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQ 175
L + E+++++A+ A++G E+ R + ++ + L K L +++
Sbjct: 769 CLLQNEKIILEAALQA---AKSGKEELDRGARRLEEGTEETSETLEK----LREELAIKS 821
Query: 176 AELEKAFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA 235
++E T K +++ + + K M E A KD+LI ELK + K ++
Sbjct: 822 GQVEHLQQETAALKKQMQKIKEQFLQQKVMVE---AYRRDATSKDQLISELKATRKRLDS 878
Query: 236 LIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKER--ETEAAQMEHQKERNSFEERIQ 293
++ L++E Q+ ++ + EL L + ++ + E QKER+ E +Q
Sbjct: 879 ELKELRQELMQVH-GEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQ 937
Query: 294 ALE--------------------EDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKK 333
+L+ E+L+++ R+ TE+K ++R + LT A K + K
Sbjct: 938 SLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGS--DLTSAQKEMKTK 995
Query: 334 VEELNSEIEKLSAAFAKAREALQKAQTQEFQ-----GSEDYETALSGK-EALSAALRSQN 387
+ + + LS +A A + A + Q GS D AL + +AL A L++ +
Sbjct: 996 HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVS 1055
Query: 388 LTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLR 447
+K+ L+ I +QEL + +++ LE +L+E+ + K I+ L +KL
Sbjct: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKK----IKRLEESNKKLA 1111
Query: 448 NEVNEREKAMENRYKSLLSESNKKLHNQEQVIK--------HLTESTNQKDVLLQKFNEK 499
E+ + + L +SN L +++ L + Q +LQ+ E+
Sbjct: 1112 LELEHEKGKLTG-----LGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166
Query: 500 DLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPG---------SKTIFSKEKKQSSDY 550
D ++ L A+ + E + E+ ++ + + S+ KK+
Sbjct: 1167 DRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK 1226
Query: 551 EELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFA----LRKQLEQDVLSY----- 601
E L+Q L+ E D ++ + S I QAEL + A L+KQL++ +
Sbjct: 1227 EHLVQKLQAEADDLQ--IREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQ 1284
Query: 602 --QNLRKTLEEQISEIR-------------RREEESFS-LYSDQTSYLSICLEENNRFQV 645
+NL+ ++++ EI+ R+E E L + S L + E+ + Q
Sbjct: 1285 EMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQK 1344
Query: 646 EHFSQEELKKKVSDLIQLVKELYTDNQHLK 675
+ F L+ KVS+L +K L NQ LK
Sbjct: 1345 DKFM---LQAKVSELKNNMKTLLQQNQQLK 1371
Score = 78.6 bits (192), Expect = 5e-14
Identities = 127/581 (21%), Positives = 240/581 (41%), Gaps = 64/581 (11%)
Query: 106 LKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRIL 165
LK+E SL ++L E + +K + A+ G E + ++A Q+++ T
Sbjct: 613 LKLENVSLSQQLTETQHRSMKEKGRIA--AQLQGIEADMLDQEAA--FMQIQEAKT---- 664
Query: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMK-KMHEGDLAMALVLDEKDRLIE 224
++E+D+ E E + LE +L ++K + + D + + E L++
Sbjct: 665 MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMK 724
Query: 225 ELKLS---LKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH 281
+L L+ L+S+E + L+ ++ GEL+G E RE +
Sbjct: 725 QLTLTQEALQSREQSLDALQTHYDEL-----QARLGELQG------EAASREDTICLL-- 771
Query: 282 QKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEI 341
Q E+ E +QA + E +R ++ + + + ++ L L K +VE L E
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQE- 830
Query: 342 EKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSI 401
+AA K + +++ Q+ E Y + K+ L + L++ RL +
Sbjct: 831 ---TAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATR-------KRLDSEL 880
Query: 402 KKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMEN-- 459
K++ QEL + E+ E +L HRE ++ + DL ++ + E +E E +++
Sbjct: 881 KELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ 940
Query: 460 ---RYKSLLSESNKKLHN-----QEQVIKHLTESTNQKDVLLQKFNEKDLEV-IQQNCYL 510
++E+N+ L Q++ K +TE + L E+ + Y
Sbjct: 941 FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYE 1000
Query: 511 MAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTH---- 566
A L R + + K ++ G S E IQ L+ E +H
Sbjct: 1001 NAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL 1060
Query: 567 LVKSLQESDSINNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREE--ESFS 624
L K LQE ++ + + E ++ L +LE ++ + RK +I+R EE + +
Sbjct: 1061 LEKELQEVIALTSQELEESREKVL--ELEDELQESRGFRK-------KIKRLEESNKKLA 1111
Query: 625 LYSDQTSYLSICLEENNRFQVEHFS--QEELKKKVSDLIQL 663
L + L ++N EH S + L K+ +DL+QL
Sbjct: 1112 LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Score = 62.0 bits (149), Expect = 5e-09
Identities = 142/722 (19%), Positives = 284/722 (39%), Gaps = 91/722 (12%)
Query: 958 QEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPPVGAAY 1017
QE T ++ +LQ L+EF+ ++L + A ++ + TLL + A
Sbjct: 660 QEAKTMVEE---DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQ 716
Query: 1018 QDSPGEQKGIKTTSSVWRDKEMDSD---------QQRSYEIDSEICPPDDLASLPSCKEN 1068
Q+ K + T + +E D Q R E+ E +D C
Sbjct: 717 QEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI----CLLQ 772
Query: 1069 PEDVLSPTSVATYLSSKSQ--PSAKVSVMGTDQ-SESINTSNETEYLKQ-KIHDLETELE 1124
E ++ ++ S K + A+ GT++ SE++ E +K ++ L+ E
Sbjct: 773 NEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETA 832
Query: 1125 GYQNFIFQLQKHSQCSEAIITVLCGTEGAQDGL-SKPKNGSDGEEMTFSSLHQVRYVKHV 1183
+ + ++++ + ++ ++D L S+ K + L Q H
Sbjct: 833 ALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHG 892
Query: 1184 KILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQ---------NKF 1234
+ A R + ++Q + + E LQ Q ++ + + +LQ +
Sbjct: 893 EKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEA 952
Query: 1235 RDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCV 1294
+ + + L Q + ++ Q+Q+++ +++ M T KA+E + +
Sbjct: 953 NEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVG------IL 1006
Query: 1295 AEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPS 1354
+ QE L +L +L ++ G ++ L ERI Q L E S
Sbjct: 1007 SRRLQEALAAKEAADAELGQL----RAQGGSSDSSLALHERI-------QALEAELQAVS 1055
Query: 1355 ASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIK 1414
S L + E E + Q+ E + V+ L + +QE R RK+++ +
Sbjct: 1056 HSKTLLEKELQEVIALT---SQELEESREKVLE-------LEDELQESRGFRKKIKRLEE 1105
Query: 1415 TNEKLRKQLERQGSEFV---QGSTSIFASGSELHSSLTSEIHFLRKQNQALNAML----- 1466
+N+KL +LE + + Q + ++ S L ++L L + N + A+L
Sbjct: 1106 SNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEE 1165
Query: 1467 -----------IKGSRDKQKEN-DKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSE 1514
++ S +K+KE + L+E ++ V H +R + + E ++KE
Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQA 1225
Query: 1515 KERHNQQLIQEVRCSGQEL----SRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEE 1570
KE L+Q+++ +L + +E+ Q L++ LQ L+ +L E+L ++
Sbjct: 1226 KE----HLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLD--EQLSKQ 1279
Query: 1571 HRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKA 1630
+E W+ R++ SL ++ Q + +E L +K +L E A
Sbjct: 1280 PVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL----EMA 1335
Query: 1631 QE 1632
QE
Sbjct: 1336 QE 1337
Score = 57.8 bits (138), Expect = 1e-07
Identities = 203/1130 (17%), Positives = 429/1130 (37%), Gaps = 136/1130 (12%)
Query: 275 EAAQMEHQKERNSFEERIQA----------LEEDLREKEREIATEKKNSLKRDKAIQGLT 324
+AA EHQ + +++ LE E + E+ K ++ + ++ L+
Sbjct: 366 QAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALS 425
Query: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALR 384
+ K+ EL +++ LS E +Q ++ S + +T L A+
Sbjct: 426 LEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMT 485
Query: 385 SQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE 444
+N L S +L +++ +RL +E+ R D T+ DLR ++
Sbjct: 486 DLQNMLEAKNASLASS----NNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMT 541
Query: 445 KLRNEVNE---REKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDL 501
L++++ + + ++ K+ +E + L + Q + + V LQ E
Sbjct: 542 ALQSQLQQVQLERTTLTSKLKASQAEIS-SLQSVRQWYQQQLALAQEARVRLQ--GEMAH 598
Query: 502 EVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQ 561
+ Q E L+L + L SQQ ++ KEK + + + I+ +Q
Sbjct: 599 IQVGQMTQAGLLEHLKLENVSL------SQQLTETQHRSMKEKGRIAAQLQGIEADMLDQ 652
Query: 562 DIYTHLVKSLQESDSI--NNLQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRRE 619
+ +QE+ ++ +LQ L + R++L++ S +L + LE+ + +R+
Sbjct: 653 EA---AFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRD 709
Query: 620 EESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIF 679
++ +L + + Q S + L+ +L + EL + + TI
Sbjct: 710 QQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTIC 769
Query: 680 DL--------SCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQ 731
L + + +G + + E + E K+ E+ I +HLQQ
Sbjct: 770 LLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQ 829
Query: 732 SNEIMKD---------LSKGGCKNGYLRHTESK---ISDCDGAHAPGCLEEGAFINLLAP 779
+K L + Y R SK IS+ E L
Sbjct: 830 ETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQ 889
Query: 780 LFNEKATLLLESRPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQKGELVHFVQT 839
+ EK T + +L ++ RE+ + + + L+G + K++ E+ +Q+
Sbjct: 890 VHGEKRT----AEAELSRLHREVAQVRQHMAD-------LEGHLQSAQKERDEMETHLQS 938
Query: 840 NSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPI 899
F K Q+V E + A + + + EA + E+K
Sbjct: 939 LQFDK----------EQMVAVTEANE-----------ALKKQIEELQQEARKAITEQKQK 977
Query: 900 NTAL-----SAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRL 954
L SA+ + H A + GI +R +++ L LG +
Sbjct: 978 MRRLGSDLTSAQKEMKTKH------KAYENAVGILSRRLQEA-LAAKEAADAELGQLRAQ 1030
Query: 955 PATQEVVTQLQSQILELQGELKEFKTCNKQLHQKL--ILAEAVMEGRPTPDKTLLNAQPP 1012
+ + L +I L+ EL+ L ++L ++A E + +K L
Sbjct: 1031 GGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVL-----E 1085
Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSY-----EIDSEICPPDDLASLPSCKE 1067
+ Q+S G +K IK + ++ + ++ + ++ + + + K
Sbjct: 1086 LEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKR 1145
Query: 1068 NPEDVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQ 1127
+ V V L K + ++ + +++ S E E K+K++ L+ ++ +
Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKHL----VQALQASLEKE--KEKVNSLKEQVAAAK 1199
Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187
++H + + ++ + A++ L + K ++ +++ Q+R KH + +
Sbjct: 1200 VEAGHNRRHFKAASLELSEVKKELQAKEHLVQ-KLQAEADDL------QIREGKHSQEIA 1252
Query: 1188 PLAPEMIDSRV-LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLV 1246
E+ ++R L+ L++QL+EQ L K+ N ++ + + K R+ +
Sbjct: 1253 QFQAELAEARAQLQLLQKQLDEQ---LSKQPVGNQEMENLKWEVDQKERE---------I 1300
Query: 1247 QSQARELSLQRQQ-IKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQC 1305
QS ++L L QQ K+ G+ + + + + A E+L + + E N
Sbjct: 1301 QSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNM 1360
Query: 1306 AELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355
LL++ ++L L+ + + T+ E N +P+ P P++
Sbjct: 1361 KTLLQQNQQLKLDLRRGAAK--TRKEPKGEASSSNPATPIKIPDCPVPAS 1408
Score = 57.0 bits (136), Expect = 2e-07
Identities = 84/438 (19%), Positives = 186/438 (42%), Gaps = 54/438 (12%)
Query: 55 TRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLK 114
T ++++ + Q+ + + N LK +I L++ ++ + + + +L + +K
Sbjct: 934 THLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMK 993
Query: 115 RE----------LQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRI 164
+ L R Q + A +A + AE G Q D+ + + L +
Sbjct: 994 TKHKAYENAVGILSRRLQEALAAKEAAD--AELGQLRAQGGSSDSSLALHERIQALEAEL 1051
Query: 165 LLLEKDVTAAQAELEKAFAGTETE----KALRLRLESKLSE-------MKKMHEGDLAMA 213
+ T + EL++ A T E + L LE +L E +K++ E + +A
Sbjct: 1052 QAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLA 1111
Query: 214 LVLD-EKDRL--IEELKLSLKSKEALIQ-CLKEEKSQMACPDENVSSGELRGLCAAPREE 269
L L+ EK +L + + +L+ ++++ L + ++ + + V + R +EE
Sbjct: 1112 LELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQR------KEE 1165
Query: 270 KERETE------AAQMEHQKER-NSFEERIQALEEDLREKER-------EIATEKKNSLK 315
++R+ + A +E +KE+ NS +E++ A + + R E++ KK
Sbjct: 1166 EDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQA 1225
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ-------GSED 368
++ +Q L + + + + EI + A A+AR LQ Q Q + G+++
Sbjct: 1226 KEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQE 1285
Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE 428
E + ++S + R+ ++ + Q L +++ E E ++DL ++
Sbjct: 1286 MENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKD 1345
Query: 429 KSKGDCTIRDLRNEVEKL 446
K + +L+N ++ L
Sbjct: 1346 KFMLQAKVSELKNNMKTL 1363
Score = 55.1 bits (131), Expect = 6e-07
Identities = 131/666 (19%), Positives = 264/666 (39%), Gaps = 112/666 (16%)
Query: 1043 QQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAKV--------SV 1094
Q Y ++ + P D L PS K DVL + A + + + +V S
Sbjct: 339 QDTPYMVNGQEIPADTLGQFPSIK----DVLQ-AAAAEHQDQGQEVNGEVRSRRDSICSS 393
Query: 1095 MGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQ 1154
+ + S + + LK+K+ LE +LE Q K +A + L AQ
Sbjct: 394 VSLESSAAETQEEMLQVLKEKMR-LEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQ 452
Query: 1155 DGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMID-SRVLENLKQQLEEQEYKL 1213
S + S + + SS +V +K + L M D +LE L L
Sbjct: 453 VECS---HSSQQRQDSLSS--EVDTLK--QSCWDLERAMTDLQNMLEAKNASLASSNNDL 505
Query: 1214 QKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQH 1273
Q + +L +++ ++Q +D Q A + LQ+ Q++ R
Sbjct: 506 QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLE---------RTT 556
Query: 1274 MNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM 1333
+ + +KA + + + V + +Q+QL E +L+ + + V TQ L+
Sbjct: 557 LTSKLKASQAEISSLQ---SVRQWYQQQLALAQEARVRLQGEMAH---IQVGQMTQAGLL 610
Query: 1334 ERIEEDNLTYQHLLPESPEPSASHA-------------LSDYETS-----------EKSF 1369
E ++ +N++ L E+ S + D E + E+
Sbjct: 611 EHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDL 670
Query: 1370 FSRDQKQDNETEKTSVMVNS---FSQDL------LMEHIQEIRTLRKR----------LE 1410
R ++ + E E+ M +S Q L L++ Q++ L++ +
Sbjct: 671 QRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQ 730
Query: 1411 ESIKTNEKLRKQLERQGSEF------VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNA 1464
E++++ E+ L+ E +QG AS + L +E L QA +
Sbjct: 731 EALQSREQSLDALQTHYDELQARLGELQGEA---ASREDTICLLQNEKIILEAALQAAKS 787
Query: 1465 ----------MLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSE 1514
L +G+ + + +KLRE L+ K+ +EHLQ+E A++K++ ++++++ +
Sbjct: 788 GKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ 847
Query: 1515 KE----------RHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAY 1564
++ QLI E++ + + L E +LRQ+L+ + + + + +
Sbjct: 848 QKVMVEAYRRDATSKDQLISELKATRKRLD--SELKELRQELMQVHGEKRTAEAELSRLH 905
Query: 1565 EKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLA 1624
++ + + + + G Q ++ + L +Q + Q+ E + L+ ++ E+L
Sbjct: 906 REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI-EELQ 964
Query: 1625 RGAEKA 1630
+ A KA
Sbjct: 965 QEARKA 970
Score = 46.2 bits (108), Expect = 3e-04
Identities = 191/1095 (17%), Positives = 412/1095 (37%), Gaps = 175/1095 (15%)
Query: 541 SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS 600
S E + EE++QVLK++ + L E+ +AEL A
Sbjct: 395 SLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAA---------- 444
Query: 601 YQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDL 660
L L+ Q+ ++ SL S+ + C + L++ ++DL
Sbjct: 445 ---LSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWD--------------LERAMTDL 487
Query: 661 IQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDE 720
+++ N L + DL ++A + L+A ED + +D+
Sbjct: 488 QNMLE---AKNASLASSNNDL------------QVAEEQYQRLMAKVEDMQRSMLSKDNT 532
Query: 721 INFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLEEGAFINLLAPL 780
++ L Q +++ + + L+ ++++IS + +
Sbjct: 533 VHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS---------------LQSVRQW 577
Query: 781 FNEKATLLLESRPDLLKVVRELLLGQL-------FLTEQEVS-GEHLDGKTEKTPKQKGE 832
+ ++ L E+R L + + +GQ+ L + VS + L ++ K+KG
Sbjct: 578 YQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGR 637
Query: 833 LVHFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATRE 892
+ +Q L EA ++ E + +D + EG+ R + A
Sbjct: 638 IAAQLQGIEADM------LDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSA 691
Query: 893 AWEEKPINTA-LSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNM 951
A E+ + L+ R + L + L+ +T +EA +SR
Sbjct: 692 ASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLT-QEALQSR-------------E 737
Query: 952 YRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQP 1011
L A Q +LQ+++ ELQGE + L + I+ EA ++ + + L
Sbjct: 738 QSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRG-- 795
Query: 1012 PVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPED 1071
A + G ++ +T + + + S Q + ++ + KE +
Sbjct: 796 ----ARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQ----MQKIKE--QF 845
Query: 1072 VLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHD----LETELEGYQ 1127
+ V Y + +S + + + E ++H E EL
Sbjct: 846 LQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLH 905
Query: 1128 NFIFQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILG 1187
+ Q+++H + EG K ++ + + L +++ K +
Sbjct: 906 REVAQVRQH----------MADLEGHLQSAQKERDEME------THLQSLQFDKEQMVAV 949
Query: 1188 PLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRD-------LSPP 1240
A E + ++ E ++ + + QK + L L S ++ K + LS
Sbjct: 950 TEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRR 1009
Query: 1241 RYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQA-SDVDYCVAEGFQ 1299
++L +A + L + + + G ++ ++ I+A E LQA S + + Q
Sbjct: 1010 LQEALAAKEAADAELGQLRAQGGSSDSSLA---LHERIQALEAELQAVSHSKTLLEKELQ 1066
Query: 1300 EQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDN----LTYQHLLPESPEPSA 1355
E + ++ LE+ + L + E + ++R+EE N L +H +
Sbjct: 1067 EVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQ 1126
Query: 1356 SHA-LSDYETSEKSFFSRDQKQ--DNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEES 1412
S+A L ++ + ++ ++ + + +V+ +D M+H+ ++ L+ LE+
Sbjct: 1127 SNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHL--VQALQASLEKE 1184
Query: 1413 IKTNEKLRKQLERQGSEFVQGSTSIFASG---SELHSSLTSEIHFLRKQNQALNAMLIKG 1469
+ L++Q+ E A+ SE+ L ++ H ++K + + I+
Sbjct: 1185 KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244
Query: 1470 SRDKQKE-----------------NDKLRESLSRKTVSLEHLQ----------REYASVK 1502
+ Q+ +L E LS++ V + ++ RE S+K
Sbjct: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
Query: 1503 EENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQ----LLSQNDKLLQSLR 1558
++ + +++G ++ QQL+Q V+ EL QE++ + Q+ L ++ +L +++
Sbjct: 1305 QQLDLTEQQGRKELEGLQQLLQNVK---SELEMAQEDLSMTQKDKFMLQAKVSELKNNMK 1361
Query: 1559 VELKAYEKLDEEHRR 1573
L+ ++L + RR
Sbjct: 1362 TLLQQNQQLKLDLRR 1376
Score = 43.5 bits (101), Expect = 0.002
Identities = 72/375 (19%), Positives = 164/375 (43%), Gaps = 31/375 (8%)
Query: 61 KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER 120
+ F +I L++ N L L + + G + ++N L+ L+ L +R
Sbjct: 1094 RGFRKKIKRLEESNKKLALEL--------EHEKGKLTGLGQSNAALREHNSILETALAKR 1145
Query: 121 EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTK---RILLLEKDVTAAQAE 177
E L++ + V+++ + E +++K VQ ++ L K ++ L++ V AA+ E
Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKH----LVQALQASLEKEKEKVNSLKEQVAAAKVE 1201
Query: 178 L---EKAFAGTETEKA-LRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSK 233
+ F E + ++ L++K ++K+ + + + + I + + L
Sbjct: 1202 AGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEA 1261
Query: 234 EALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQ 293
A +Q L+++ + + V + E+ L ++KERE ++ + + + ++
Sbjct: 1262 RAQLQLLQKQLDEQLSK-QPVGNQEMENL-KWEVDQKEREIQSLKQQLDLTEQQGRKELE 1319
Query: 294 ALEEDLR--EKEREIATEKKNSLKRDK-AIQGLTMALKSKEKKVEELNSEIE-KLSAAFA 349
L++ L+ + E E+A E + ++DK +Q LK+ K + + N +++ L A
Sbjct: 1320 GLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAA 1379
Query: 350 KAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS 409
K R+ + + S + T + + A + L + + +K + L
Sbjct: 1380 KTRK-----EPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVS-KEPLKNLNSCLQ 1433
Query: 410 DLQQERERLEKDLEE 424
L+QE + L++ +EE
Sbjct: 1434 QLKQEMDSLQRQMEE 1448
Score = 42.7 bits (99), Expect = 0.003
Identities = 118/552 (21%), Positives = 212/552 (38%), Gaps = 95/552 (17%)
Query: 1199 LENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFR------DLSPPRYDSLVQSQARE 1252
LE +K L +++ +L+ Q ++ L ++ Q + D YD L QAR
Sbjct: 698 LEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDEL---QARL 754
Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQAS-----DVDYCVAEGFQEQLNQCAE 1307
LQ + IC++ + + E LQA+ ++D A +E + +E
Sbjct: 755 GELQGEAASREDTICLLQNEKI-----ILEAALQAAKSGKEELDRG-ARRLEEGTEETSE 808
Query: 1308 LLEKL--EKLFLNGKSVGVEMNTQ--NELMERIEEDNLTYQHLLPESPEPSAS--HALSD 1361
LEKL E +G+ ++ T + M++I+E L + ++ + S +S+
Sbjct: 809 TLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE 868
Query: 1362 YETSEKSFFSR------------DQKQDNETEKTSV-----MVNSFSQDL---------- 1394
+ + K S +K+ E E + + V DL
Sbjct: 869 LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKE 928
Query: 1395 ---LMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSE 1451
+ H+Q ++ ++++ + NE L+KQ+E E + T L S LTS
Sbjct: 929 RDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSA 988
Query: 1452 IHFLRKQNQAL------------NAMLIKGSRDKQKENDKLRESLSRKTVSL----EHLQ 1495
++ +++A A+ K + D + + + S +++L + L+
Sbjct: 989 QKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALE 1048
Query: 1496 REYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQEL-SRVQEEVKLR---QQLLSQND 1551
E +V L+KE E Q ++E R EL +QE R ++L N
Sbjct: 1049 AELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNK 1108
Query: 1552 KLLQSLRVELKAYEKLDEEHRRLREASG--EGWKGQDPFRDLHSLLMEIQA--------- 1600
KL L E L + + LRE + E + DL L +++QA
Sbjct: 1109 KLALELEHEKGKLTGLGQSNAALREHNSILETALAKRE-ADLVQLNLQVQAVLQRKEEED 1167
Query: 1601 -----LRLQLERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEV--PLQPDK 1653
L L+ S+E + LKEQ+A +A ++ + EV LQ +
Sbjct: 1168 RQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKE 1227
Query: 1654 HDGDKYPMESDN 1665
H K E+D+
Sbjct: 1228 HLVQKLQAEADD 1239
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 96.7 bits (239), Expect = 2e-19
Identities = 142/623 (22%), Positives = 294/623 (47%), Gaps = 83/623 (13%)
Query: 66 QITELKKENFNLKLRIYFLEERMQQEFHGPTE--HIYKTNIELKVEVESLKRELQEREQL 123
+ +L+K N +L+I L+E++++ TE + + + K E +LQ RE
Sbjct: 623 EYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRED- 681
Query: 124 LIKASKAV-ESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAF 182
+S+ + + L EA E++ +A+ Q +E L ++ E+ + +++K
Sbjct: 682 ---SSEGIRKKLVEA--EELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDL 736
Query: 183 AGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEE--LKLSLKSKEALIQCL 240
A ET + + R E + E K+ AM +D K R +E+ ++LS +K A L
Sbjct: 737 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 796
Query: 241 KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALE-EDL 299
+++ M +E +S ELR +++ ET+A ++E Q + EE+++ + +D
Sbjct: 797 FTQRN-MKAQEEMIS--ELR------QQKFYLETQAGKLEAQNRK--LEEQLEKISHQDH 845
Query: 300 REKEREIATE---KKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQ 356
+K R + E ++ SL+ ++ L L + ++E S++ L AA A L+
Sbjct: 846 SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 905
Query: 357 KAQTQEFQGSEDYETALSGKEALSA----------ALRSQNLTKSTENHRLRRSIKKITQ 406
+A+T+ + + + E + +AL+A ALR+ + T T+ L + ++T+
Sbjct: 906 QAKTELEETTAEAEEEI---QALTAHRDEIQRKFDALRN-SCTVITD---LEEQLNQLTE 958
Query: 407 ELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLS 466
+ ++L + L K L+EA S + I LR+EV+ LR E+ ERE + ++ +++ +
Sbjct: 959 DNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 1014
Query: 467 ESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDL-------EVIQQNCYLMAAEDLELR 519
+EQV+ E+ N D LL+K + + E Q C + + +
Sbjct: 1015 LKTTCTMLEEQVMD--LEALN--DELLEKERQWEAWRSVLGDEKSQFECRVRELQRM--- 1067
Query: 520 SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINN 579
L TEK S+ + S++ + + E ++L +Q + +K+ SD +N+
Sbjct: 1068 ---LDTEK-QSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLND 1123
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEE 639
L+ + + + L+Q + + + L++ L E+ ++++++ + L++
Sbjct: 1124 LEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD----------------LQK 1167
Query: 640 NNRFQVEHFSQEELKKKVSDLIQ 662
N+ F++ QE L + +DL++
Sbjct: 1168 NHIFRLTQGLQEALDR--ADLLK 1188
Score = 73.9 bits (180), Expect = 1e-12
Identities = 124/576 (21%), Positives = 241/576 (41%), Gaps = 81/576 (14%)
Query: 160 LTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK-MHEGDLAMALVLDE 218
+ K++L+ K++ +Q + K E E RL ++SE++ + + ++ + +
Sbjct: 447 MEKKLLIKSKELQDSQDKCHKM----EQEMT---RLHRRVSEVEAVLSQKEVELKASETQ 499
Query: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
+ L ++L + +L + L++ + +++ D+ L RE+ + E +
Sbjct: 500 RSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQ-----LLHDIREQSRKLQEIKE 554
Query: 279 MEHQKERNSFEERIQALEEDL--------------------REKEREIATEKKNSLKRDK 318
E+Q + + LEEDL E+ + ATE ++ L + K
Sbjct: 555 QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAK 614
Query: 319 AIQG---------LTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDY 369
QG L ++ K++EL ++EK A +A E LQ + + + +
Sbjct: 615 D-QGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAEREL 673
Query: 370 ETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELS-DLQQERERLEKDLEEAHRE 428
E L +E S +R + L ++ E R + Q L L+Q+ + E+ ++ +
Sbjct: 674 E-KLQNREDSSEGIR-KKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQ 731
Query: 429 KSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTEST-- 486
K L N +++ E +E+ K + + K++++ + K+ + EQ I L+E+
Sbjct: 732 IKKDLADKETLENMMQRHEEEAHEKGKILSEQ-KAMINAMDSKIRSLEQRIVELSEANKL 790
Query: 487 -------NQKDVLLQKFNEKDLEVIQQNCYL-MAAEDLELRSEGL--ITEKCSSQQPPGS 536
Q+++ Q+ E E+ QQ YL A LE ++ L EK S Q
Sbjct: 791 AANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848
Query: 537 KTIFSKE---KKQSSDYEELIQVLKKEQDIYTHLVKSLQESDS-INNLQAELNKIFALRK 592
+ E ++ S ++EE LK++ T L SLQE +S + LQA AL
Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQ---LTELQLSLQERESQLTALQAAR---AALES 902
Query: 593 QLEQDVLSYQNLRKTLEEQISEIRRREEE----------SFSLYSDQTSYLSICLEENNR 642
QL Q + EE+I + +E S ++ +D L+ E+N
Sbjct: 903 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 962
Query: 643 FQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTI 678
++F + + S + +L ++ HL++ I
Sbjct: 963 LNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREI 998
Score = 69.7 bits (169), Expect = 3e-11
Identities = 102/435 (23%), Positives = 186/435 (42%), Gaps = 47/435 (10%)
Query: 49 EETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKV 108
E A+N K E Q+ ++ ++ + K R+ LE R+++ EH + +ELK
Sbjct: 820 ETQAGKLEAQNRK-LEEQLEKISHQDHSDKNRLLELETRLREV---SLEH-EEQKLELKR 874
Query: 109 EVESLKRELQEREQLLIK---ASKAVESLAEAGGSEIQRVKEDARKKVQQV---EDLLTK 162
++ L+ LQERE L A A+ES +E++ +A +++Q + D + +
Sbjct: 875 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQR 934
Query: 163 RILLLEKDVTAAQAELEKAFAGTETEKALRLR---LESKLSEMKKMHEGDLAMALVLDEK 219
+ L T E+ TE L + L +L E ++ + + +D
Sbjct: 935 KFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 994
Query: 220 DRLIEELKLSLKSKEALIQCLKEEKSQMA--CPDENVSSGELRGLCAAPREEKERETEAA 277
R I E ++ L S++ ++ LK + + D + EL EKER+ EA
Sbjct: 995 RREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELL--------EKERQWEAW 1046
Query: 278 QMEHQKERNSFEERIQAL------EEDLREKEREIATEKKN----SLKRDKA-IQGLTMA 326
+ E++ FE R++ L E+ R + + TE + ++K KA I L A
Sbjct: 1047 RSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQA 1106
Query: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQ 386
LK ++ K E L+ ++ L + + A+ + + Q + E L + L + Q
Sbjct: 1107 LKEQKLKAESLSDKLNDL-----EKKHAMLEMNARSLQQKLETERELK-QRLLEEQAKLQ 1160
Query: 387 NLTKSTENH--RLRRSIKKITQELSDLQQERERLEKDLEEAH----REKSKGDCTIRDLR 440
+NH RL + +++ L+ ER LE LE EK K + TI
Sbjct: 1161 QQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQT 1220
Query: 441 NEVEKLRNEVNEREK 455
++ L+ ++++ K
Sbjct: 1221 KLIDFLQAKMDQPAK 1235
Score = 57.8 bits (138), Expect = 1e-07
Identities = 76/346 (21%), Positives = 140/346 (40%), Gaps = 54/346 (15%)
Query: 62 DFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQERE 121
D E Q+ +L ++N L + ++L +++ E G + I ++L+ EV+ L+RE+ ERE
Sbjct: 948 DLEEQLNQLTEDNAELNNQNFYLSKQLD-EASGANDEI----VQLRSEVDHLRREITERE 1002
Query: 122 QLLIKASKAVESLA-----------------------------------------EAGGS 140
L + +E+L E
Sbjct: 1003 MQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVR 1062
Query: 141 EIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLS 200
E+QR+ + ++ + + +T+ ++E V +AE+ + +K L KL+
Sbjct: 1063 ELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLN 1122
Query: 201 EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEA-LIQCLKEEKSQMACPDENVSSG-E 258
+++K H A L +K ELK L ++A L Q + +K+ + + + +
Sbjct: 1123 DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD 1182
Query: 259 LRGLCAAPREEKERETEAAQMEHQKERNSFEERIQ---ALEEDLREKEREIATEKKNSLK 315
L R + E + E Q+ + E+ E I L + L+ K + A +KK
Sbjct: 1183 RADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFS 1242
Query: 316 RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQ 361
R K L + + EL +EK A A+ EALQK + +
Sbjct: 1243 RRKEDPALPTQV---PLQYNELKLALEKEKARCAELEEALQKTRIE 1285
Score = 52.0 bits (123), Expect = 5e-06
Identities = 165/763 (21%), Positives = 300/763 (39%), Gaps = 131/763 (17%)
Query: 465 LSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLI 524
L +S K H EQ + L ++ + +L + E +L+ + L+ +DL I
Sbjct: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ-KEVELKASETQRSLLE-QDLAT----YI 511
Query: 525 TEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLK--KEQDIYTHLVKSLQESDSINNLQA 582
TE CSS + +++ + S + ++ +Q+L +EQ + LQE QA
Sbjct: 512 TE-CSSLK----RSLEQARMEVSQEDDKALQLLHDIREQS------RKLQEIKE-QEYQA 559
Query: 583 ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNR 642
++ ++ + QLE+D++S + E ++ E R EE F + + + + ++ +
Sbjct: 560 QVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEE-FKRKATECQHKLLKAKDQGK 618
Query: 643 FQVEHFS----------------QEELKKKV---SDLIQLVKELYTDNQHLKKTIFDLSC 683
+V ++ QE+L+K V ++ +L++ + + ++ + L
Sbjct: 619 PEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQN 678
Query: 684 MGFQGNGFPDRLASTEQTELLASKEDEDTIKIGEDDEINFLSDQHLQQ-----SNEIMKD 738
G +L E+ E K E + + +QH ++ N+I KD
Sbjct: 679 REDSSEGIRKKLVEAEELE---EKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKD 735
Query: 739 LS-KGGCKNGYLRHTESKISDCDGAHAPGCL--EEGAFINLLAPLFNEKATLLLE-SRPD 794
L+ K +N RH E AH G + E+ A IN + ++E S +
Sbjct: 736 LADKETLENMMQRHEEE-------AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEAN 788
Query: 795 LL----------------KVVRELLLGQLFLTEQ----EVSGEHLDGKTEKTPKQ----K 830
L +++ EL + +L Q E L+ + EK Q K
Sbjct: 789 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848
Query: 831 GELVHF-VQTNSFSKPHDELKLSCEAQLVK---AGEVPKVGLKDASVQTVATEGDLLRFK 886
L+ + S H+E KL + QL + + + + L A E L + K
Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 908
Query: 887 ---HEATREAWEEKPINTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIK 943
E T EA EE TA HR E + A S IT+ E +L L +
Sbjct: 909 TELEETTAEAEEEIQALTA----HRDEIQR---KFDALRNSCTVITDLE---EQLNQLTE 958
Query: 944 PSRSLGN--------MYRLPATQEVVTQLQSQILELQGELKEFK---TCNKQLHQKL--- 989
+ L N + + + QL+S++ L+ E+ E + T KQ + L
Sbjct: 959 DNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 1018
Query: 990 --ILAEAVMEGRPTPDKTLLNAQPPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSY 1047
+L E VM+ D+ L + A++ G++K + +D+++Q
Sbjct: 1019 CTMLEEQVMDLEALNDELLEKERQ--WEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRA 1076
Query: 1048 EIDSEICPPDDLASLPSCKENPEDVLSPTSV-------ATYLSSKSQPSAKVSVMGTDQS 1100
D I + L + KE+ ++L+ A LS K K M +
Sbjct: 1077 RADQRITESRQVVEL-AVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNA 1135
Query: 1101 ESINTSNETE-YLKQKIHD----LETELEGYQNFIFQLQKHSQ 1138
S+ ETE LKQ++ + L+ +++ +N IF+L + Q
Sbjct: 1136 RSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ 1178
Score = 52.0 bits (123), Expect = 5e-06
Identities = 107/476 (22%), Positives = 186/476 (39%), Gaps = 92/476 (19%)
Query: 1195 DSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRD--LSPPRYDSLVQSQARE 1252
D R Q+++EQEY+ Q E E+ + N+ + +S R L +S+ RE
Sbjct: 541 DIREQSRKLQEIKEQEYQAQVE---------EMRLMMNQLEEDLVSARRRSDLYESELRE 591
Query: 1253 LSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDV------DYCVAEGFQ-EQLNQC 1305
L ++ K C QH +LL+A D +Y E EQ +
Sbjct: 592 SRLAAEEFKRKATEC----QH---------KLLKAKDQGKPEVGEYAKLEKINAEQQLKI 638
Query: 1306 AELLEKLEK----------LFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSA 1355
EL EKLEK L N + + E ++ E+ + + L E+ E
Sbjct: 639 QELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEE 698
Query: 1356 SHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKT 1415
H + + QK+ + EK V+ N +DL ++ LE ++
Sbjct: 699 KHREAQVSAQHLEVHLK-QKEQHYEEKIKVLDNQIKKDL---------ADKETLENMMQR 748
Query: 1416 NEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQK 1475
+E ++ +G + I A S++ S + A N+ L K +
Sbjct: 749 HE---EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ 805
Query: 1476 ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERH------NQQLIQEVRCS 1529
E E +S +L+ + ++ +N +L+ E EK H N+ L E R
Sbjct: 806 E-----EMISELRQQKFYLETQAGKLEAQNRKLE-EQLEKISHQDHSDKNRLLELETRLR 859
Query: 1530 GQELSRVQEEVKLRQQL------LSQNDKLLQSLRVELKAYE-KLDEEHRRLREASGEGW 1582
L +++++L++QL L + + L +L+ A E +L + L E + E
Sbjct: 860 EVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAE 919
Query: 1583 KGQDPFRDLHSLLMEIQAL---RLQLER---SIETSSTLQSRLKEQLARGAEKAQE 1632
+ EIQAL R +++R ++ S T+ + L+EQL + E E
Sbjct: 920 E-------------EIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 962
Score = 50.8 bits (120), Expect = 1e-05
Identities = 119/593 (20%), Positives = 228/593 (38%), Gaps = 88/593 (14%)
Query: 1086 SQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIIT 1145
++ K+ + +++ S E L Q I + E + +LQ SE I
Sbjct: 632 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAE---RELEKLQNREDSSEGIRK 688
Query: 1146 VLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKIL-GPLAPEMIDSRVLENLKQ 1204
L E ++ + + + E+ Q Y + +K+L + ++ D LEN+ Q
Sbjct: 689 KLVEAEELEEKHREAQVSAQHLEVHLKQKEQ-HYEEKIKVLDNQIKKDLADKETLENMMQ 747
Query: 1205 QLEEQEYK----LQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQI 1260
+ EE+ ++ L +++ + + S+I +L+ + +LS +A +L+
Sbjct: 748 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS----------EANKLAANSS-- 795
Query: 1261 KDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGK 1320
+ ++++M + EL Q A + Q + E LEK+ + K
Sbjct: 796 -------LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 848
Query: 1321 SVGVEMNTQ-NELMERIEEDNLTYQHLLPE---SPEPSASHALSDYETSEKSFFSRDQKQ 1376
+ +E+ T+ E+ EE L + L E S + S L+ + + + S+ ++
Sbjct: 849 NRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ-LTALQAARAALESQLRQA 907
Query: 1377 DNETEKTSVMVNSFSQ-------------DLLMEHIQEIRTLRKRLEESIKTNEKLRKQ- 1422
E E+T+ Q D L I L ++L + + N +L Q
Sbjct: 908 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQN 967
Query: 1423 --LERQGSEFVQGSTSIFASGSE---LHSSLTSEIHFLRKQNQALNA------MLIKGSR 1471
L +Q E + I SE L +T L Q Q + A ML +
Sbjct: 968 FYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVM 1027
Query: 1472 DKQKENDKLRES--------------LSRKTVSLEHLQREYASVKEENERLQKEGSEKER 1517
D + ND+L E S+ + LQR + K+ R + +E +
Sbjct: 1028 DLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 1087
Query: 1518 HNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREA 1577
+ ++E + L + +E KL+ + LS DKL L+++H L
Sbjct: 1088 VVELAVKEHKAEILALQQALKEQKLKAESLS--DKL-----------NDLEKKHAMLEMN 1134
Query: 1578 SGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEKA 1630
+ + + R+L L+E QA +L++ ++ RL + L ++A
Sbjct: 1135 ARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHIFRLTQGLQEALDRA 1184
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 96.7 bits (239), Expect = 2e-19
Identities = 117/564 (20%), Positives = 247/564 (43%), Gaps = 57/564 (10%)
Query: 90 QEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEI-QRVK-E 147
Q+ E K EL++ + L+ + E L ES ++ +E +R++ E
Sbjct: 1264 QQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAE 1323
Query: 148 DARKKVQQVEDLLTKRILLLEKDVTAAQ----AELEKAFAGTETEKALRLRLESKLSEM- 202
K++Q D L K++ ++E +V A+ AE+ + RL+ E + E+
Sbjct: 1324 KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVD 1383
Query: 203 --KKMHEGDLAMALVLDEK-----DRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVS 255
KK + + L ++++ +R + +L+ + + +Q LK+ K Q + +
Sbjct: 1384 FTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKK-KCQRLTAELQDT 1442
Query: 256 SGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQA--LEEDLREKEREIATEKKNS 313
L G ++ + E E Q E + E Q L+ + ++E+++ + S
Sbjct: 1443 KLHLEG-----QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 314 LK-----RDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSED 368
LK +D I G T + S E ++++++S+ K A+ AK ++ L+ + + +D
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKV----KD 1553
Query: 369 YETALSGKEALSAALRSQNLTKSTENHRLRRSIKK--------ITQELSDLQQERERLEK 420
E L + L L E R+R++ K + + Q++ +++E
Sbjct: 1554 QEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEV 1613
Query: 421 DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK 480
LEE + +K K R+L ++ L ++VN R+ E R + L + L + + ++
Sbjct: 1614 QLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLD 1673
Query: 481 HLTESTNQKDVLLQKFNEKD-------LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQP 533
HL S K + Q N+ + V + + EDL L+ + + K + ++
Sbjct: 1674 HLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEE- 1732
Query: 534 PGSKTIFSKEKKQ-----SSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIF 588
+ +EK + D E++ +++KK + + L + IN+LQA+L +
Sbjct: 1733 --QLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ---INDLQAQLEEAN 1787
Query: 589 ALRKQLEQDVLSYQNLRKTLEEQI 612
+++L++ + + Q+ + LE+ +
Sbjct: 1788 KEKQELQEKLQALQSQVEFLEQSM 1811
Score = 82.4 bits (202), Expect = 4e-15
Identities = 149/672 (22%), Positives = 270/672 (40%), Gaps = 128/672 (19%)
Query: 83 FLEERMQQEFHGPTEHIYKTNIELKVEVESL-KRELQEREQLLIKASKAVESLAEAGGSE 141
F ++R+QQEF E K+EVE KR+L+ R L +A E
Sbjct: 1384 FTKKRLQQEF------------EDKLEVEQQNKRQLERRLGDL-----------QADSEE 1420
Query: 142 IQRVKEDARKKVQQVEDLLTKRILLLE-KDVTAAQAELEKAFAGTETEKALRLRLESKLS 200
QR + +KK Q++ L L LE + V + E ++ +E +A KL
Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480
Query: 201 EMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
K E D+ +A LK L+ K+ I ++ + +++SS E +
Sbjct: 1481 REKLQREKDMLLAEAF--------SLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 261 GLCAAPREEKE-RETEAAQMEHQKERNSFEERIQALEE-DLR---EKEREIATEKKNSLK 315
+ + +K+ R+ EA + ++E + IQ LE+ LR E ER T K
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMES 1592
Query: 316 RDKAIQGLTMALKSKEKKVE-ELNSEIEKLSAAFAKAREALQKAQT-------QEFQGSE 367
RD+ ++ + + K K++E +L E E + RE K T ++F+ +
Sbjct: 1593 RDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEK 1652
Query: 368 DYETALSGKEAL--SAALRSQNLTKSTENHRLRRSIKKITQELSDLQ-------QERERL 418
L +AL A L +L S + +R I ++ +L + + + R+ +
Sbjct: 1653 RLRKDLKRTKALLADAQLMLDHLKNSAPS---KREIAQLKNQLEESEFTCAAAVKARKAM 1709
Query: 419 EKDLEEAH-------REKSKGDCTIRDLRNEVEKLRNEVNEREKAME---NRYKSLLSES 468
E ++E+ H + K+ + + L+ E +++N + E ++ M ++K+ ++++
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQA 1769
Query: 469 NKKLHNQEQVIKHLTESTNQKDVLLQKFN--EKDLEVIQQNCYLMAAEDLELRSEGLITE 526
++ L + L E+ +K L +K + +E ++Q+ M + L R E I E
Sbjct: 1770 SRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQS---MVDKSLVSRQEAKIRE 1826
Query: 527 KCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNK 586
+T E+ Q E L LK+ + K +E D +
Sbjct: 1827 ---------LETRLEFERTQVKRLESLASRLKENME------KLTEERD---------QR 1862
Query: 587 IFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVE 646
I A ++ EQ+ + LR T +E++ E+ R+E E+
Sbjct: 1863 IAAENREKEQNKRLQRQLRDT-KEEMGELARKEAEASR---------------------- 1899
Query: 647 HFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLAS 706
+ EL+ + L + L D + K I DL D + S E +L+ S
Sbjct: 1900 --KKHELEMDLESLEAANQSLQADLKLAFKRIGDLQA------AIEDEMESDENEDLINS 1951
Query: 707 KEDEDTIKIGED 718
+ D D ED
Sbjct: 1952 EGDSDVDSELED 1963
Score = 63.2 bits (152), Expect = 2e-09
Identities = 84/436 (19%), Positives = 183/436 (41%), Gaps = 41/436 (9%)
Query: 267 REEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMA 326
++E+ ++ + + +KERN LE + E E+ E+ + + T
Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAE 1318
Query: 327 LKSKEKKVEELNSEIEKLSAAFAKAREALQKA---QTQEFQGSEDYETALSGKEAL--SA 381
EK+++EL ++ + L + +A + E G D + A G+ L
Sbjct: 1319 RLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA-GGEWRLKYER 1377
Query: 382 ALRSQNLTKSTENHRL-------RRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDC 434
A+R + TK +++ +++ + L DLQ + E ++ L++ ++ +
Sbjct: 1378 AVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTA 1437
Query: 435 TIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLL- 493
++D + +E + +E EK + R+ S LS+++++ ++ + L +KD+LL
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEK-KQRRFDSELSQAHEEAQREKLQREKL---QREKDMLLA 1493
Query: 494 ------QKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQS 547
Q+ EKD+++ + LE + + S Q + +K KKQ
Sbjct: 1494 EAFSLKQQLEEKDMDIAG---FTQKVVSLEAELQDI------SSQESKDEASLAKVKKQL 1544
Query: 548 SDYEELIQVLKKEQDIYTHLVKSLQ------ESDSINNLQAELNKIFALRKQLEQDVLSY 601
D E ++ ++E D ++ L+ E + Q ++ + +++E+ S
Sbjct: 1545 RDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSC 1604
Query: 602 QNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLI 661
Q K +E Q+ E +++ + L+ ++ NR E S++ L+K +
Sbjct: 1605 QKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE--SEKRLRKDLKRTK 1662
Query: 662 QLVKELYTDNQHLKKT 677
L+ + HLK +
Sbjct: 1663 ALLADAQLMLDHLKNS 1678
Score = 49.7 bits (117), Expect = 3e-05
Identities = 110/614 (17%), Positives = 234/614 (38%), Gaps = 109/614 (17%)
Query: 953 RLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQPP 1012
+L Q+ QL+ ++ +LQ + +E + +QL +K A ++ T L+ +
Sbjct: 1396 KLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQD------TKLHLEGQ 1449
Query: 1013 VGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDV 1072
++ +++ S + + + Q+ + + ++ + + +E D+
Sbjct: 1450 QVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDI 1509
Query: 1073 LSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQ 1132
T L ++ Q + S D++ + L+ K+ D E EL+ I
Sbjct: 1510 AGFTQKVVSLEAELQDIS--SQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567
Query: 1133 LQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPE 1192
L+ +A + + E + SK D EE+ + + +K +++ L E
Sbjct: 1568 LE------QAKLRLEMEMERMRQTHSKEMESRD-EEVEEARQSCQKKLKQMEV--QLEEE 1618
Query: 1193 MIDSRVLENLKQQLE---------------EQEYKLQKEQNLNMQLFSEIHNLQNKFRDL 1237
D + + K++LE E E +L+K+ L ++ + + ++
Sbjct: 1619 YEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678
Query: 1238 SPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEEL-LQASDVDYCVAE 1296
+P + RE++ + Q+++ C + + M E+L LQ D+
Sbjct: 1679 APSK---------REIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT- 1728
Query: 1297 GFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSAS 1356
+EQL++ +NE+ R+EED L+
Sbjct: 1729 ALEEQLSRL--------------------QREKNEIQNRLEEDQEDMNELM--------- 1759
Query: 1357 HALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTN 1416
+K V S+DL +I L+ +LEE+ K
Sbjct: 1760 ------------------------KKHKAAVAQASRDLA-----QINDLQAQLEEANKEK 1790
Query: 1417 EKLRKQLERQGS--EFVQGST---SIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSR 1471
++L+++L+ S EF++ S S+ + L + + F R Q + L ++ +
Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKE 1850
Query: 1472 DKQK---ENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRC 1528
+ +K E D+ + +R+ + LQR+ KEE L ++ +E R +L ++
Sbjct: 1851 NMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLES 1910
Query: 1529 SGQELSRVQEEVKL 1542
+Q ++KL
Sbjct: 1911 LEAANQSLQADLKL 1924
Score = 47.0 bits (110), Expect = 2e-04
Identities = 68/319 (21%), Positives = 149/319 (46%), Gaps = 32/319 (10%)
Query: 400 SIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMEN 459
S ++I + ++QQ R +LEK A +E+++ L + + +L +E+ + E+
Sbjct: 1252 SEEQIRNKDEEIQQLRSKLEK----AEKERNELRLNSDRLESRISELTSELTDERNTGES 1307
Query: 460 RYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELR 519
+ L +E+ ++L + K + E Q D L ++ ++EV++ A + E+
Sbjct: 1308 ASQLLDAETAERLRAE----KEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVD 1363
Query: 520 SEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINN 579
+ E + + F+K++ Q ++E+ ++V ++ + + LQ +DS +
Sbjct: 1364 DDDAGGEWRLKYERAVREVDFTKKRLQ-QEFEDKLEVEQQNKRQLERRLGDLQ-ADSEES 1421
Query: 580 LQAELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEE 639
+A + L+K+ ++ Q+ + LE Q ++R E E D S LS EE
Sbjct: 1422 QRA----LQQLKKKCQRLTAELQDTKLHLEGQ--QVRNHELEKKQRRFD--SELSQAHEE 1473
Query: 640 NNRFQVEHFSQEELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTE 699
R E +E+L+++ L+ E ++ Q L++ D++ GF ++ S E
Sbjct: 1474 AQR---EKLQREKLQREKD---MLLAEAFSLKQQLEEKDMDIA-------GFTQKVVSLE 1520
Query: 700 -QTELLASKEDEDTIKIGE 717
+ + ++S+E +D + +
Sbjct: 1521 AELQDISSQESKDEASLAK 1539
Score = 45.1 bits (105), Expect = 7e-04
Identities = 96/471 (20%), Positives = 184/471 (39%), Gaps = 51/471 (10%)
Query: 1391 SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTS 1450
S++ + +EI+ LR +LE++ K +LR +R S SEL S LT
Sbjct: 1252 SEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRI-----------SELTSELTD 1300
Query: 1451 EIHFLRKQNQALNAMLI------KGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEE 1504
E + +Q L+A K ++ Q + D L++ + + + +E ++ E
Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQM--EVMEMEVMEARLIRAAEI 1358
Query: 1505 NERLQKE--GSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELK 1562
N + + G E ++ ++EV + + R+Q+E + + ++ QN + L+ +L+
Sbjct: 1359 NGEVDDDDAGGEWRLKYERAVREVDFTKK---RLQQEFEDKLEVEQQNKRQLERRLGDLQ 1415
Query: 1563 AYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLER-----SIETSSTLQS 1617
A +E R L++ + + +D L Q +LE+ E S +
Sbjct: 1416 A--DSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1473
Query: 1618 RLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKH-----------DGDKYPMESDNS 1666
+E+L R EK Q L +A S+ + + D + + + S S
Sbjct: 1474 AQREKLQR--EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQES 1531
Query: 1667 FDLFDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRH 1726
D ++S A K + + + + L +G+ RL + +
Sbjct: 1532 KD--EASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Query: 1727 VLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTA 1786
+ E+ E + Q+ L +M++Q +E + L K L+ V+
Sbjct: 1590 MESRDEEVEEARQSC---QKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1646
Query: 1787 KLTLEEAYRRLKLLWRVSLPEDGQCPL-HCEQIGEMKAEVTKLHKKLFEQE 1836
E+ R+ L +L D Q L H + K E+ +L +L E E
Sbjct: 1647 DFESEKRLRK-DLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESE 1696
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,797,188
Number of Sequences: 37866
Number of extensions: 3283442
Number of successful extensions: 34500
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 414
Number of HSP's successfully gapped in prelim test: 1321
Number of HSP's that attempted gapping in prelim test: 14297
Number of HSP's gapped (non-prelim): 10638
length of query: 1893
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1776
effective length of database: 13,817,196
effective search space: 24539340096
effective search space used: 24539340096
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.