Guide to the Human Genome
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Search of human proteins with 57863263

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|57863263 testis expressed sequence 14 isoform a [Homo
sapiens]
         (1491 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|57863263 testis expressed sequence 14 isoform a [Homo sapiens]    2994   0.0  
gi|57863261 testis expressed sequence 14 isoform b [Homo sapiens]    2894   0.0  
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]           81   9e-15
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]         81   9e-15
gi|4503787 fyn-related kinase [Homo sapiens]                           78   7e-14
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           75   6e-13
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            75   6e-13
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...    74   1e-12
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo...    73   2e-12
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo...    73   2e-12
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho...    73   2e-12
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...    72   3e-12
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                     72   4e-12
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...    72   4e-12
gi|187475373 c-src tyrosine kinase [Homo sapiens]                      71   7e-12
gi|4758078 c-src tyrosine kinase [Homo sapiens]                        71   7e-12
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2...    70   1e-11
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1...    70   1e-11
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    70   2e-11
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    70   2e-11
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...    70   2e-11
gi|148596974 TXK tyrosine kinase [Homo sapiens]                        69   3e-11
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...    69   3e-11
gi|29725609 epidermal growth factor receptor isoform a precursor...    68   8e-11
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                      67   1e-10
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              67   1e-10
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                67   1e-10
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              67   1e-10
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              67   1e-10
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              67   1e-10

>gi|57863263 testis expressed sequence 14 isoform a [Homo sapiens]
          Length = 1491

 Score = 2994 bits (7763), Expect = 0.0
 Identities = 1491/1491 (100%), Positives = 1491/1491 (100%)

Query: 1    MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60
            MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
Sbjct: 1    MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60

Query: 61   FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120
            FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
Sbjct: 61   FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120

Query: 121  RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180
            RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
Sbjct: 121  RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180

Query: 181  GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240
            GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
Sbjct: 181  GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240

Query: 241  EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300
            EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
Sbjct: 241  EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300

Query: 301  LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360
            LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
Sbjct: 301  LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360

Query: 361  LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420
            LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
Sbjct: 361  LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420

Query: 421  VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480
            VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
Sbjct: 421  VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480

Query: 481  IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540
            IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
Sbjct: 481  IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540

Query: 541  TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600
            TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
Sbjct: 541  TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600

Query: 601  PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660
            PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
Sbjct: 601  PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660

Query: 661  EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720
            EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
Sbjct: 661  EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720

Query: 721  TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780
            TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
Sbjct: 721  TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780

Query: 781  AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840
            AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
Sbjct: 781  AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840

Query: 841  CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900
            CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
Sbjct: 841  CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900

Query: 901  RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960
            RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
Sbjct: 901  RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960

Query: 961  AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020
            AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
Sbjct: 961  AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020

Query: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTP 1080
            SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTP
Sbjct: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTP 1080

Query: 1081 DGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS 1140
            DGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS
Sbjct: 1081 DGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS 1140

Query: 1141 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA 1200
            QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA
Sbjct: 1141 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA 1200

Query: 1201 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK 1260
            PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK
Sbjct: 1201 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK 1260

Query: 1261 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH 1320
            KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH
Sbjct: 1261 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH 1320

Query: 1321 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM 1380
            IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM
Sbjct: 1321 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM 1380

Query: 1381 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR 1440
            LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR
Sbjct: 1381 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR 1440

Query: 1441 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD 1491
            KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
Sbjct: 1441 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD 1491


>gi|57863261 testis expressed sequence 14 isoform b [Homo sapiens]
          Length = 1451

 Score = 2894 bits (7503), Expect = 0.0
 Identities = 1451/1491 (97%), Positives = 1451/1491 (97%), Gaps = 40/1491 (2%)

Query: 1    MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60
            MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
Sbjct: 1    MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60

Query: 61   FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120
            FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
Sbjct: 61   FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120

Query: 121  RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180
            RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
Sbjct: 121  RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180

Query: 181  GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240
            GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
Sbjct: 181  GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240

Query: 241  EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300
            EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
Sbjct: 241  EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300

Query: 301  LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360
            LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
Sbjct: 301  LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360

Query: 361  LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420
            LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
Sbjct: 361  LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420

Query: 421  VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480
            VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
Sbjct: 421  VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480

Query: 481  IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540
            IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
Sbjct: 481  IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540

Query: 541  TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600
            TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
Sbjct: 541  TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600

Query: 601  PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660
            PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
Sbjct: 601  PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660

Query: 661  EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720
            EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
Sbjct: 661  EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720

Query: 721  TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780
            TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
Sbjct: 721  TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780

Query: 781  AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840
            AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
Sbjct: 781  AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840

Query: 841  CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900
            CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
Sbjct: 841  CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900

Query: 901  RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960
            RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
Sbjct: 901  RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960

Query: 961  AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020
            AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
Sbjct: 961  AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020

Query: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTP 1080
            SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS                       
Sbjct: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS----------------------- 1057

Query: 1081 DGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS 1140
                             TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS
Sbjct: 1058 -----------------TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS 1100

Query: 1141 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA 1200
            QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA
Sbjct: 1101 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA 1160

Query: 1201 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK 1260
            PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK
Sbjct: 1161 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK 1220

Query: 1261 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH 1320
            KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH
Sbjct: 1221 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH 1280

Query: 1321 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM 1380
            IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM
Sbjct: 1281 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM 1340

Query: 1381 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR 1440
            LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR
Sbjct: 1341 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR 1400

Query: 1441 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD 1491
            KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
Sbjct: 1401 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD 1451


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 102/416 (24%), Positives = 181/416 (43%), Gaps = 81/416 (19%)

Query: 83  NHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRL---------HDERGQNPKTWALTAG 133
           NH+  DG T +H+A + G+  ++  LLD G D+ L          ++  Q    WA   G
Sbjct: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393

Query: 134 KERSTQIVEFMQR------CASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCGGLVQGNP 187
            +    +++  +R      C  + Q    G SY            V  PS  G +     
Sbjct: 394 HDAIVTLLKHYKRPQDELPCNEYSQPGGDG-SY------------VSVPSPLGKIKSMTK 440

Query: 188 NGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADDEPTFSFF 247
             +   LL+AG+ S           F+L    Q++ +    +IG                
Sbjct: 441 EKADILLLRAGLPS----------HFHL----QLSEIEFHEIIG---------------- 470

Query: 248 SGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAV 307
           SG +  +         V +K     T+  CS+  + D+   E     +L HP ++Q +  
Sbjct: 471 SGSFGKVYKGRCRNKIVAIKRYRANTY--CSKSDV-DMFCREVSILCQLNHPCVIQFVGA 527

Query: 308 CLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLH--FQG 365
           CL+ D  +  +V + I+ G+LFS+LHE++    +L ++  + + + ++  + YLH   Q 
Sbjct: 528 CLN-DPSQFAIVTQYISGGSLFSLLHEQKR---ILDLQSKLIIAVDVAKGMEYLHNLTQP 583

Query: 366 FIHRSLSSYAVHIISPGEARLTNL--EYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVIL 423
            IHR L+S+ + +   G A + +      L+S D   + ++T+ P   +   W APEV  
Sbjct: 584 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLD---EDNMTKQPGNLR---WMAPEVFT 637

Query: 424 QKAA-TVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPY 478
           Q    T+K+D++S+++ + EILT +IP+  L     K A  + +     +R P  Y
Sbjct: 638 QCTRYTIKADVFSYALCLWEILTGEIPFAHL-----KPAAAAADMAYHHIRPPIGY 688



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 33/107 (30%), Positives = 52/107 (48%)

Query: 27  LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
           LH  V + N   +  +L  G  +  V   G TAL +A + G  +  DVL+ +G++ N + 
Sbjct: 105 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 164

Query: 87  FDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAG 133
               TP+H AA+ G++ +   LL  G D+ +  E G  P   A   G
Sbjct: 165 AVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 211



 Score = 35.8 bits (81), Expect = 0.32
 Identities = 25/108 (23%), Positives = 47/108 (43%)

Query: 34  GNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPV 93
           G    ++ ++ KG+    +   G TAL +A      + +  L+  G+D     + G T +
Sbjct: 79  GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138

Query: 94  HAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAGKERSTQIV 141
           H A  +G+      LL  G ++ + D     P   A   G E+ T+++
Sbjct: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 26/101 (25%), Positives = 44/101 (43%), Gaps = 2/101 (1%)

Query: 27  LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
           LH     G+      +L+ G  V+  +++  T L +AA  G  +   +L+ +G+D N   
Sbjct: 138 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 197

Query: 87  FDGSTPVHAAAFSGNQWILSKLLDAG--GDLRLHDERGQNP 125
             G  P+H A+  G   I   L++ G   D+   D     P
Sbjct: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 102/416 (24%), Positives = 181/416 (43%), Gaps = 81/416 (19%)

Query: 83  NHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRL---------HDERGQNPKTWALTAG 133
           NH+  DG T +H+A + G+  ++  LLD G D+ L          ++  Q    WA   G
Sbjct: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494

Query: 134 KERSTQIVEFMQR------CASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCGGLVQGNP 187
            +    +++  +R      C  + Q    G SY            V  PS  G +     
Sbjct: 495 HDAIVTLLKHYKRPQDELPCNEYSQPGGDG-SY------------VSVPSPLGKIKSMTK 541

Query: 188 NGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADDEPTFSFF 247
             +   LL+AG+ S           F+L    Q++ +    +IG                
Sbjct: 542 EKADILLLRAGLPS----------HFHL----QLSEIEFHEIIG---------------- 571

Query: 248 SGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAV 307
           SG +  +         V +K     T+  CS+  + D+   E     +L HP ++Q +  
Sbjct: 572 SGSFGKVYKGRCRNKIVAIKRYRANTY--CSKSDV-DMFCREVSILCQLNHPCVIQFVGA 628

Query: 308 CLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLH--FQG 365
           CL+ D  +  +V + I+ G+LFS+LHE++    +L ++  + + + ++  + YLH   Q 
Sbjct: 629 CLN-DPSQFAIVTQYISGGSLFSLLHEQKR---ILDLQSKLIIAVDVAKGMEYLHNLTQP 684

Query: 366 FIHRSLSSYAVHIISPGEARLTNL--EYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVIL 423
            IHR L+S+ + +   G A + +      L+S D   + ++T+ P   +   W APEV  
Sbjct: 685 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLD---EDNMTKQPGNLR---WMAPEVFT 738

Query: 424 QKAA-TVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPY 478
           Q    T+K+D++S+++ + EILT +IP+  L     K A  + +     +R P  Y
Sbjct: 739 QCTRYTIKADVFSYALCLWEILTGEIPFAHL-----KPAAAAADMAYHHIRPPIGY 789



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 33/107 (30%), Positives = 52/107 (48%)

Query: 27  LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
           LH  V + N   +  +L  G  +  V   G TAL +A + G  +  DVL+ +G++ N + 
Sbjct: 206 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 265

Query: 87  FDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAG 133
               TP+H AA+ G++ +   LL  G D+ +  E G  P   A   G
Sbjct: 266 AVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 312



 Score = 35.8 bits (81), Expect = 0.32
 Identities = 25/108 (23%), Positives = 47/108 (43%)

Query: 34  GNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPV 93
           G    ++ ++ KG+    +   G TAL +A      + +  L+  G+D     + G T +
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239

Query: 94  HAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAGKERSTQIV 141
           H A  +G+      LL  G ++ + D     P   A   G E+ T+++
Sbjct: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 26/101 (25%), Positives = 44/101 (43%), Gaps = 2/101 (1%)

Query: 27  LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
           LH     G+      +L+ G  V+  +++  T L +AA  G  +   +L+ +G+D N   
Sbjct: 239 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 298

Query: 87  FDGSTPVHAAAFSGNQWILSKLLDAG--GDLRLHDERGQNP 125
             G  P+H A+  G   I   L++ G   D+   D     P
Sbjct: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score = 77.8 bits (190), Expect = 7e-14
 Identities = 62/250 (24%), Positives = 117/250 (46%), Gaps = 18/250 (7%)

Query: 248 SGPYMVMTNLVWNGSR-VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMA 306
           SG +  +   +WN +  V VK L   +      LR A ++         LRHP L+QL A
Sbjct: 242 SGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM-------KNLRHPKLIQLYA 294

Query: 307 VCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGF 366
           VC  +D     ++ E +  G+L   L         +H+   V +  Q++  + YL  + +
Sbjct: 295 VCTLED--PIYIITELMRHGSLQEYLQNDTGS--KIHLTQQVDMAAQVASGMAYLESRNY 350

Query: 367 IHRSLSSYAVHIISPGEARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQ 424
           IHR L++  V +      ++ +  L  + + ++  +      + LP +   W APE I  
Sbjct: 351 IHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK---WTAPEAIRS 407

Query: 425 KAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIVK 483
              ++KSD++SF +++ EI+T   +P+ G+ G+ V + +     L      P+ +Y+I+ 
Sbjct: 408 NKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIML 467

Query: 484 SGIHVKQKDR 493
              + + K+R
Sbjct: 468 ECWNAEPKER 477


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 55/204 (26%), Positives = 101/204 (49%), Gaps = 14/204 (6%)

Query: 282 LADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPV 341
           L D L+AE     +L +PY+++++ +C   + E   LV E   +G L   L + R     
Sbjct: 390 LKDELLAEANVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYLQQNRH---- 442

Query: 342 LHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDRG 399
           +  + I+ L+ Q+S  ++YL    F+HR L++  V +++   A++++  L   L + D  
Sbjct: 443 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA-DEN 501

Query: 400 VQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVV 458
             +  T    P +   W APE I     + KSD++SF ++M E  +    P++G+ GS V
Sbjct: 502 YYKAQTHGKWPVK---WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 558

Query: 459 KKAVVSGNYLEADVRLPKPYYDIV 482
              +  G  +      P+  YD++
Sbjct: 559 TAMLEKGERMGCPAGCPREMYDLM 582


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 55/204 (26%), Positives = 101/204 (49%), Gaps = 14/204 (6%)

Query: 282 LADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPV 341
           L D L+AE     +L +PY+++++ +C   + E   LV E   +G L   L + R     
Sbjct: 413 LKDELLAEANVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYLQQNRH---- 465

Query: 342 LHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDRG 399
           +  + I+ L+ Q+S  ++YL    F+HR L++  V +++   A++++  L   L + D  
Sbjct: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA-DEN 524

Query: 400 VQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVV 458
             +  T    P +   W APE I     + KSD++SF ++M E  +    P++G+ GS V
Sbjct: 525 YYKAQTHGKWPVK---WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581

Query: 459 KKAVVSGNYLEADVRLPKPYYDIV 482
              +  G  +      P+  YD++
Sbjct: 582 TAMLEKGERMGCPAGCPREMYDLM 605


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 68/234 (29%), Positives = 110/234 (47%), Gaps = 24/234 (10%)

Query: 259 WNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRL 318
           W G  V VK          S    A+ +  E    + L HP ++ L AVCL +      L
Sbjct: 136 WRGELVAVKAARQDPDEDISVT--AESVRQEARLFAMLAHPNIIALKAVCLEEP--NLCL 191

Query: 319 VYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGF---IHRSLSSYA 375
           V E    G L   L  RR     +   V+V+  +QI+  + YLH +     IHR L S  
Sbjct: 192 VMEYAAGGPLSRALAGRR-----VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNN 246

Query: 376 VHIISPGEARLTNLEYM-LESEDRGVQRDLTRVPLPTQL-----YNWAAPEVILQKAATV 429
           + ++ P E+   ++E+  L+  D G+ R+  +    TQ+     Y W APEVI     + 
Sbjct: 247 ILLLQPIES--DDMEHKTLKITDFGLAREWHKT---TQMSAAGTYAWMAPEVIKASTFSK 301

Query: 430 KSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAV-VSGNYLEADVRLPKPYYDIV 482
            SD++SF +++ E+LT ++P++G+D   V   V V+   L      P+P+  ++
Sbjct: 302 GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM 355


>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
           4 isoform JM-a/CVT-2 precursor [Homo sapiens]
          Length = 1292

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 57/216 (26%), Positives = 110/216 (50%), Gaps = 23/216 (10%)

Query: 264 VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERI 323
           V +K LN  T P  +   + + LI      + + HP+L++L+ VCLS  ++   LV + +
Sbjct: 748 VAIKILNETTGPKANVEFMDEALIM-----ASMDHPHLVRLLGVCLSPTIQ---LVTQLM 799

Query: 324 TIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGE 383
             G L   +HE +     +  +++++  +QI+  + YL  +  +HR L++  V + SP  
Sbjct: 800 PHGCLLEYVHEHKDN---IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH 856

Query: 384 ARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQ 441
            ++T+  L  +LE +++    D  ++P+      W A E I  +  T +SD++S+ + + 
Sbjct: 857 VKITDFGLARLLEGDEKEYNADGGKMPI-----KWMALECIHYRKFTHQSDVWSYGVTIW 911

Query: 442 EILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKP 477
           E++T     K  DG   ++     + LE   RLP+P
Sbjct: 912 ELMT--FGGKPYDGIPTREI---PDLLEKGERLPQP 942


>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
           isoform JM-a/CVT-1 precursor [Homo sapiens]
          Length = 1308

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 57/216 (26%), Positives = 110/216 (50%), Gaps = 23/216 (10%)

Query: 264 VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERI 323
           V +K LN  T P  +   + + LI      + + HP+L++L+ VCLS  ++   LV + +
Sbjct: 748 VAIKILNETTGPKANVEFMDEALIM-----ASMDHPHLVRLLGVCLSPTIQ---LVTQLM 799

Query: 324 TIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGE 383
             G L   +HE +     +  +++++  +QI+  + YL  +  +HR L++  V + SP  
Sbjct: 800 PHGCLLEYVHEHKDN---IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH 856

Query: 384 ARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQ 441
            ++T+  L  +LE +++    D  ++P+      W A E I  +  T +SD++S+ + + 
Sbjct: 857 VKITDFGLARLLEGDEKEYNADGGKMPI-----KWMALECIHYRKFTHQSDVWSYGVTIW 911

Query: 442 EILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKP 477
           E++T     K  DG   ++     + LE   RLP+P
Sbjct: 912 ELMT--FGGKPYDGIPTREI---PDLLEKGERLPQP 942


>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
           sapiens]
          Length = 966

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 55/214 (25%), Positives = 93/214 (43%), Gaps = 13/214 (6%)

Query: 291 EHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHL 350
           +H  KL+HP ++    VC         ++ E    G L+ VL   R   P L    +V  
Sbjct: 206 KHLRKLKHPNIIAFKGVCTQAPCYC--IIMEYCAHGQLYEVLRAGRKITPRL----LVDW 259

Query: 351 LLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLP 410
              I+  + YLH    IHR L S  V +      ++++     E  D+  +         
Sbjct: 260 STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVA- 318

Query: 411 TQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGN-YLE 469
                W APEVI  +  + K DI+SF +++ E+LT +IP+K +D S +   V S + +L 
Sbjct: 319 -----WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 373

Query: 470 ADVRLPKPYYDIVKSGIHVKQKDRTMNLQDIRYI 503
                P  +  ++K     K ++R    Q + ++
Sbjct: 374 VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 407


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 17/197 (8%)

Query: 281 RLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFP 340
           ++ DL   + +H  KL+HP ++    VC         ++ E    G L+ VL   R   P
Sbjct: 153 KVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYC--ILMEFCAQGQLYEVLRAGRPVTP 210

Query: 341 VLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGV 400
            L    +V   + I+  + YLH    IHR L S  + I      ++++     E  D+  
Sbjct: 211 SL----LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKST 266

Query: 401 QRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKK 460
           +              W APEVI  +  + K DI+SF +++ E+LT +IP+K +D S +  
Sbjct: 267 KMSFAGTVA------WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 320

Query: 461 AVVSGNYLEADVRLPKP 477
            V S +     + LP P
Sbjct: 321 GVGSNS-----LHLPVP 332


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 70/254 (27%), Positives = 112/254 (44%), Gaps = 25/254 (9%)

Query: 248 SGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAV 307
           +G +  +    W G  V VK       P       A+ +  E    + LRHP +++L  V
Sbjct: 132 AGGFGQVYRATWQGQEVAVKAAR--QDPEQDAAAAAESVRREARLFAMLRHPNIIELRGV 189

Query: 308 CLSQDLEKTRLVYERITIGTLFSVLHE------------RRSQFPVLHMEVIVHLLLQIS 355
           CL Q      LV E    G L   L              RR++    H  V+V+  +QI+
Sbjct: 190 CLQQP--HLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPH--VLVNWAVQIA 245

Query: 356 DALRYLHFQGFI---HRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQ 412
             + YLH + F+   HR L S  + ++   E         L+  D G+ R+  R    + 
Sbjct: 246 RGMLYLHEEAFVPILHRDLKSSNILLLEKIEHD-DICNKTLKITDFGLAREWHRTTKMST 304

Query: 413 L--YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAV-VSGNYLE 469
              Y W APEVI     +  SDI+S+ +++ E+LT ++P++G+DG  V   V V+   L 
Sbjct: 305 AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP 364

Query: 470 ADVRLPKPYYDIVK 483
                P+P+  ++K
Sbjct: 365 IPSTCPEPFAKLMK 378


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 64/232 (27%), Positives = 109/232 (46%), Gaps = 18/232 (7%)

Query: 259 WNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRL 318
           W G  V VK          S+    + +  E +  + L+HP ++ L  VCL +      L
Sbjct: 163 WIGDEVAVKAARHDPDEDISQT--IENVRQEAKLFAMLKHPNIIALRGVCLKEP--NLCL 218

Query: 319 VYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGF---IHRSLSSYA 375
           V E    G L  VL  +R     +  +++V+  +QI+  + YLH +     IHR L S  
Sbjct: 219 VMEFARGGPLNRVLSGKR-----IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSN 273

Query: 376 VHIISPGE-ARLTNLEYMLESEDRGVQRDLTRVPLPTQL--YNWAAPEVILQKAATVKSD 432
           + I+   E   L+N   +L+  D G+ R+  R    +    Y W APEVI     +  SD
Sbjct: 274 ILILQKVENGDLSNK--ILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSD 331

Query: 433 IYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNY-LEADVRLPKPYYDIVK 483
           ++S+ +++ E+LT ++P++G+DG  V   V      L      P+P+  +++
Sbjct: 332 VWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLME 383


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 12/217 (5%)

Query: 283 ADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVL 342
           A   +AE    ++LRH  L+QL+ V + ++     +V E +  G+L   L  R     VL
Sbjct: 230 AQAFLAEASVMTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRS--VL 286

Query: 343 HMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQR 402
             + ++   L + +A+ YL    F+HR L++  V +     A++++     E+      +
Sbjct: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---Q 343

Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
           D  ++P+      W APE + +K  + KSD++SF +++ EI +   +P+  +    V   
Sbjct: 344 DTGKLPV-----KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398

Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQ 498
           V  G  ++A    P   Y+++K+  H+    R   LQ
Sbjct: 399 VEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 12/217 (5%)

Query: 283 ADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVL 342
           A   +AE    ++LRH  L+QL+ V + ++     +V E +  G+L   L  R     VL
Sbjct: 230 AQAFLAEASVMTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRS--VL 286

Query: 343 HMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQR 402
             + ++   L + +A+ YL    F+HR L++  V +     A++++     E+      +
Sbjct: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---Q 343

Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
           D  ++P+      W APE + +K  + KSD++SF +++ EI +   +P+  +    V   
Sbjct: 344 DTGKLPV-----KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398

Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQ 498
           V  G  ++A    P   Y+++K+  H+    R   LQ
Sbjct: 399 VEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435


>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
           [Homo sapiens]
          Length = 312

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 56/212 (26%), Positives = 105/212 (49%), Gaps = 15/212 (7%)

Query: 286 LIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHME 345
           ++ E +   +L +PY+++L+ VC ++ L    LV E    G L   L  +R + PV ++ 
Sbjct: 76  MMREAQIMHQLDNPYIVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREEIPVSNVA 132

Query: 346 VIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDR-GVQR 402
            ++H   Q+S  ++YL  + F+HR L++  V +++   A++++  L   L ++D     R
Sbjct: 133 ELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 189

Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
              + PL      W APE I  +  + +SD++S+ + M E L+    P+K + G  V   
Sbjct: 190 SAGKWPL-----KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 244

Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDR 493
           +  G  +E     P   Y ++      K +DR
Sbjct: 245 IEQGKRMECPPECPPELYALMSDCWIYKWEDR 276


>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
           [Homo sapiens]
          Length = 619

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 56/212 (26%), Positives = 105/212 (49%), Gaps = 15/212 (7%)

Query: 286 LIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHME 345
           ++ E +   +L +PY+++L+ VC ++ L    LV E    G L   L  +R + PV ++ 
Sbjct: 383 MMREAQIMHQLDNPYIVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREEIPVSNVA 439

Query: 346 VIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDR-GVQR 402
            ++H   Q+S  ++YL  + F+HR L++  V +++   A++++  L   L ++D     R
Sbjct: 440 ELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496

Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
              + PL      W APE I  +  + +SD++S+ + M E L+    P+K + G  V   
Sbjct: 497 SAGKWPL-----KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551

Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDR 493
           +  G  +E     P   Y ++      K +DR
Sbjct: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDR 583


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 52/205 (25%), Positives = 98/205 (47%), Gaps = 19/205 (9%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQI 354
           +++HP L+QL+ VC  +      ++ E +T G L   L E   Q   ++  V++++  QI
Sbjct: 292 EIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQ--EVNAVVLLYMATQI 347

Query: 355 SDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL- 413
           S A+ YL  + FIHR L++            L    ++++  D G+ R +T         
Sbjct: 348 SSAMEYLEKKNFIHRDLAARNC---------LVGENHLVKVADFGLSRLMTGDTYTAHAG 398

Query: 414 ----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNYL 468
                 W APE +     ++KSD+++F +++ EI T  + P+ G+D S V + +     +
Sbjct: 399 AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM 458

Query: 469 EADVRLPKPYYDIVKSGIHVKQKDR 493
           E     P+  Y+++++       DR
Sbjct: 459 ERPEGCPEKVYELMRACWQWNPSDR 483


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 52/205 (25%), Positives = 98/205 (47%), Gaps = 19/205 (9%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQI 354
           +++HP L+QL+ VC  +      ++ E +T G L   L E   Q   ++  V++++  QI
Sbjct: 311 EIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQ--EVNAVVLLYMATQI 366

Query: 355 SDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL- 413
           S A+ YL  + FIHR L++            L    ++++  D G+ R +T         
Sbjct: 367 SSAMEYLEKKNFIHRDLAARNC---------LVGENHLVKVADFGLSRLMTGDTYTAHAG 417

Query: 414 ----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNYL 468
                 W APE +     ++KSD+++F +++ EI T  + P+ G+D S V + +     +
Sbjct: 418 AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM 477

Query: 469 EADVRLPKPYYDIVKSGIHVKQKDR 493
           E     P+  Y+++++       DR
Sbjct: 478 ERPEGCPEKVYELMRACWQWNPSDR 502


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 101/228 (44%), Gaps = 18/228 (7%)

Query: 258 VWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTR 317
           +W G  V VK   L   P       A+ +  E      L+HP ++ L   CL+       
Sbjct: 116 LWRGEEVAVKAARLD--PEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPP--HLC 171

Query: 318 LVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQG---FIHRSLSSY 374
           LV E    G L  VL  RR     +   V+V+  +Q++  + YLH       IHR L S 
Sbjct: 172 LVMEYARGGALSRVLAGRR-----VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226

Query: 375 AVHIISPGEARLTNL-EYMLESEDRGVQRDLTRVPLPTQL--YNWAAPEVILQKAATVKS 431
            + I+   E    NL + +L+  D G+ R+  +    +    Y W APEVI     +  S
Sbjct: 227 NILILEAIENH--NLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSS 284

Query: 432 DIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNY-LEADVRLPKPY 478
           D++SF +++ E+LT ++P++ +D   V   V      L      P+P+
Sbjct: 285 DVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPF 332


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 56/211 (26%), Positives = 101/211 (47%), Gaps = 16/211 (7%)

Query: 287 IAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEV 346
           I E +   KL H  L+QL  VC+ +  +   +V E +  G L + L E + +   L  E+
Sbjct: 312 IEEAKVMMKLSHSKLVQLYGVCIQR--KPLYIVTEFMENGCLLNYLRENKGK---LRKEM 366

Query: 347 IVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNL---EYMLESEDRGVQRD 403
           ++ +   I + + YL   G+IHR L++    + S    ++++     Y+L+  D  V   
Sbjct: 367 LLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLD--DEYVSSF 424

Query: 404 LTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILTD-DIPWKGLDGSVVKKAV 462
             + P+      W+ PEV L    + KSD++SF ++M E+ T+  +P++      V +A+
Sbjct: 425 GAKFPI-----KWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAI 479

Query: 463 VSGNYLEADVRLPKPYYDIVKSGIHVKQKDR 493
             G  L      P   Y+++ S  H K + R
Sbjct: 480 SEGFRLYRPHLAPMSIYEVMYSCWHEKPEGR 510


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 62/235 (26%), Positives = 106/235 (45%), Gaps = 31/235 (13%)

Query: 289 EQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLH------------ERR 336
           E E  + L+H ++++   VC   D +   +V+E +  G L   L             + R
Sbjct: 588 EAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPR 645

Query: 337 SQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESE 396
                L +  ++H+  QI+  + YL  Q F+HR L++            L     +++  
Sbjct: 646 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNC---------LVGANLLVKIG 696

Query: 397 DRGVQRDLT-----RVPLPTQL-YNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIP 449
           D G+ RD+      RV   T L   W  PE I+ +  T +SD++SF +I+ EI T    P
Sbjct: 697 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756

Query: 450 WKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQDIRYIL 504
           W  L  + V + +  G  LE     PK  YD++  G   ++  + +N+++I  IL
Sbjct: 757 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVM-LGCWQREPQQRLNIKEIYKIL 810


>gi|29725609 epidermal growth factor receptor isoform a precursor
           [Homo sapiens]
          Length = 1210

 Score = 67.8 bits (164), Expect = 8e-11
 Identities = 50/217 (23%), Positives = 109/217 (50%), Gaps = 25/217 (11%)

Query: 264 VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERI 323
           V +KEL   T P  ++  L +  +      + + +P++ +L+ +CL+  ++   L+ + +
Sbjct: 742 VAIKELREATSPKANKEILDEAYVM-----ASVDNPHVCRLLGICLTSTVQ---LITQLM 793

Query: 324 TIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGE 383
             G L   + E +     +  + +++  +QI+  + YL  +  +HR L++  V + +P  
Sbjct: 794 PFGCLLDYVREHKDN---IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH 850

Query: 384 ARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQ 441
            ++T+  L  +L +E++    +  +VP+      W A E IL +  T +SD++S+ + + 
Sbjct: 851 VKITDFGLAKLLGAEEKEYHAEGGKVPI-----KWMALESILHRIYTHQSDVWSYGVTVW 905

Query: 442 EILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRLPKP 477
           E++T    P+ G+  S +       + LE   RLP+P
Sbjct: 906 ELMTFGSKPYDGIPASEI------SSILEKGERLPQP 936


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 49/190 (25%), Positives = 92/190 (48%), Gaps = 13/190 (6%)

Query: 298 HPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDA 357
           HP++L L  V   +  +   ++ E +  G L + L ER  Q   L    +V +L  I+  
Sbjct: 682 HPHILHLEGVVTKR--KPIMIITEFMENGALDAFLREREDQ---LVPGQLVAMLQGIASG 736

Query: 358 LRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYN 415
           + YL    ++HR L++  + +      ++++  L  +L+  D   +    ++P+      
Sbjct: 737 MNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPI-----R 791

Query: 416 WAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRL 474
           W APE I  +  T  SD++SF ++M E+L+  D P+  +    V K++  G  L   V  
Sbjct: 792 WTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDC 851

Query: 475 PKPYYDIVKS 484
           P P Y+++K+
Sbjct: 852 PAPLYELMKN 861


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
           +++HP L+QL+ VC  +      +V E +  G L   L E  R +   +   V++++  Q
Sbjct: 323 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 377

Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
           IS A+ YL  + FIHR L++            L    ++++  D G+ R +T        
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 428

Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
                  W APE +     ++KSD+++F +++ EI T  + P+ G+D S V   +  G  
Sbjct: 429 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 488

Query: 468 LEADVRLPKPYYDIVKS 484
           +E     P   Y+++++
Sbjct: 489 MEQPEGCPPKVYELMRA 505


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
           +++HP L+QL+ VC  +      +V E +  G L   L E  R +   +   V++++  Q
Sbjct: 338 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 392

Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
           IS A+ YL  + FIHR L++            L    ++++  D G+ R +T        
Sbjct: 393 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 443

Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
                  W APE +     ++KSD+++F +++ EI T  + P+ G+D S V   +  G  
Sbjct: 444 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 503

Query: 468 LEADVRLPKPYYDIVKS 484
           +E     P   Y+++++
Sbjct: 504 MEQPEGCPPKVYELMRA 520


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
           +++HP L+QL+ VC  +      +V E +  G L   L E  R +   +   V++++  Q
Sbjct: 317 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 371

Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
           IS A+ YL  + FIHR L++            L    ++++  D G+ R +T        
Sbjct: 372 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 422

Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
                  W APE +     ++KSD+++F +++ EI T  + P+ G+D S V   +  G  
Sbjct: 423 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 482

Query: 468 LEADVRLPKPYYDIVKS 484
           +E     P   Y+++++
Sbjct: 483 MEQPEGCPPKVYELMRA 499


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
           +++HP L+QL+ VC  +      +V E +  G L   L E  R +   +   V++++  Q
Sbjct: 323 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 377

Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
           IS A+ YL  + FIHR L++            L    ++++  D G+ R +T        
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 428

Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
                  W APE +     ++KSD+++F +++ EI T  + P+ G+D S V   +  G  
Sbjct: 429 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 488

Query: 468 LEADVRLPKPYYDIVKS 484
           +E     P   Y+++++
Sbjct: 489 MEQPEGCPPKVYELMRA 505


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)

Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
           +++HP L+QL+ VC  +      +V E +  G L   L E  R +   +   V++++  Q
Sbjct: 302 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 356

Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
           IS A+ YL  + FIHR L++            L    ++++  D G+ R +T        
Sbjct: 357 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 407

Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
                  W APE +     ++KSD+++F +++ EI T  + P+ G+D S V   +  G  
Sbjct: 408 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 467

Query: 468 LEADVRLPKPYYDIVKS 484
           +E     P   Y+++++
Sbjct: 468 MEQPEGCPPKVYELMRA 484


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.129    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,279,856
Number of Sequences: 37866
Number of extensions: 3062169
Number of successful extensions: 14309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 410
Number of HSP's successfully gapped in prelim test: 679
Number of HSP's that attempted gapping in prelim test: 10845
Number of HSP's gapped (non-prelim): 3654
length of query: 1491
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1376
effective length of database: 13,892,928
effective search space: 19116668928
effective search space used: 19116668928
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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