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Search of human proteins with 57863261
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57863261 testis expressed sequence 14 isoform b [Homo
sapiens]
(1451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57863261 testis expressed sequence 14 isoform b [Homo sapiens] 2914 0.0
gi|57863263 testis expressed sequence 14 isoform a [Homo sapiens] 2894 0.0
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 81 8e-15
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 81 8e-15
gi|4503787 fyn-related kinase [Homo sapiens] 78 7e-14
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 75 6e-13
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 75 6e-13
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 74 1e-12
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 73 2e-12
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 73 2e-12
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 73 2e-12
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 72 3e-12
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 72 4e-12
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 72 4e-12
gi|187475373 c-src tyrosine kinase [Homo sapiens] 71 7e-12
gi|4758078 c-src tyrosine kinase [Homo sapiens] 71 7e-12
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 70 1e-11
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 70 1e-11
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 70 1e-11
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 70 1e-11
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 70 1e-11
gi|148596974 TXK tyrosine kinase [Homo sapiens] 69 3e-11
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 69 3e-11
gi|29725609 epidermal growth factor receptor isoform a precursor... 68 7e-11
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 67 1e-10
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 67 1e-10
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 67 1e-10
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 67 1e-10
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 67 1e-10
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 67 1e-10
>gi|57863261 testis expressed sequence 14 isoform b [Homo sapiens]
Length = 1451
Score = 2914 bits (7554), Expect = 0.0
Identities = 1451/1451 (100%), Positives = 1451/1451 (100%)
Query: 1 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60
MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
Sbjct: 1 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60
Query: 61 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120
FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
Sbjct: 61 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120
Query: 121 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180
RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
Sbjct: 121 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180
Query: 181 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240
GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
Sbjct: 181 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240
Query: 241 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300
EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
Sbjct: 241 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300
Query: 301 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360
LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
Sbjct: 301 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360
Query: 361 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420
LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
Sbjct: 361 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420
Query: 421 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480
VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
Sbjct: 421 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480
Query: 481 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540
IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
Sbjct: 481 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540
Query: 541 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600
TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
Sbjct: 541 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600
Query: 601 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660
PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
Sbjct: 601 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660
Query: 661 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720
EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
Sbjct: 661 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720
Query: 721 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780
TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
Sbjct: 721 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780
Query: 781 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840
AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
Sbjct: 781 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840
Query: 841 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900
CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
Sbjct: 841 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900
Query: 901 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960
RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
Sbjct: 901 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960
Query: 961 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020
AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
Sbjct: 961 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020
Query: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSTSSPIEEDFEGIQGAFAQPQVSG 1080
SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSTSSPIEEDFEGIQGAFAQPQVSG
Sbjct: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSTSSPIEEDFEGIQGAFAQPQVSG 1080
Query: 1081 EEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSIS 1140
EEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSIS
Sbjct: 1081 EEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSIS 1140
Query: 1141 YEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWN 1200
YEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWN
Sbjct: 1141 YEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWN 1200
Query: 1201 SQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSS 1260
SQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSS
Sbjct: 1201 SQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSS 1260
Query: 1261 PPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTA 1320
PPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTA
Sbjct: 1261 PPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTA 1320
Query: 1321 NDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDL 1380
NDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDL
Sbjct: 1321 NDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDL 1380
Query: 1381 PKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSR 1440
PKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSR
Sbjct: 1381 PKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSR 1440
Query: 1441 IIVLDQSDLSD 1451
IIVLDQSDLSD
Sbjct: 1441 IIVLDQSDLSD 1451
>gi|57863263 testis expressed sequence 14 isoform a [Homo sapiens]
Length = 1491
Score = 2894 bits (7503), Expect = 0.0
Identities = 1451/1491 (97%), Positives = 1451/1491 (97%), Gaps = 40/1491 (2%)
Query: 1 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60
MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
Sbjct: 1 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL 60
Query: 61 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120
FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
Sbjct: 61 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE 120
Query: 121 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180
RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
Sbjct: 121 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG 180
Query: 181 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240
GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
Sbjct: 181 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD 240
Query: 241 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300
EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
Sbjct: 241 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY 300
Query: 301 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360
LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
Sbjct: 301 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY 360
Query: 361 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420
LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
Sbjct: 361 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE 420
Query: 421 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480
VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
Sbjct: 421 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD 480
Query: 481 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540
IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
Sbjct: 481 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL 540
Query: 541 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600
TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
Sbjct: 541 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA 600
Query: 601 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660
PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
Sbjct: 601 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM 660
Query: 661 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720
EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
Sbjct: 661 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS 720
Query: 721 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780
TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
Sbjct: 721 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN 780
Query: 781 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840
AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
Sbjct: 781 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ 840
Query: 841 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900
CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
Sbjct: 841 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST 900
Query: 901 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960
RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
Sbjct: 901 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE 960
Query: 961 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020
AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
Sbjct: 961 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG 1020
Query: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS----------------------- 1057
SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS
Sbjct: 1021 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTP 1080
Query: 1058 -----------------TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS 1100
TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS
Sbjct: 1081 DGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS 1140
Query: 1101 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA 1160
QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA
Sbjct: 1141 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA 1200
Query: 1161 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK 1220
PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK
Sbjct: 1201 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK 1260
Query: 1221 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH 1280
KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH
Sbjct: 1261 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH 1320
Query: 1281 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM 1340
IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM
Sbjct: 1321 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM 1380
Query: 1341 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR 1400
LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR
Sbjct: 1381 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR 1440
Query: 1401 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD 1451
KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
Sbjct: 1441 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD 1491
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 80.9 bits (198), Expect = 8e-15
Identities = 102/416 (24%), Positives = 181/416 (43%), Gaps = 81/416 (19%)
Query: 83 NHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRL---------HDERGQNPKTWALTAG 133
NH+ DG T +H+A + G+ ++ LLD G D+ L ++ Q WA G
Sbjct: 334 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 393
Query: 134 KERSTQIVEFMQR------CASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCGGLVQGNP 187
+ +++ +R C + Q G SY V PS G +
Sbjct: 394 HDAIVTLLKHYKRPQDELPCNEYSQPGGDG-SY------------VSVPSPLGKIKSMTK 440
Query: 188 NGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADDEPTFSFF 247
+ LL+AG+ S F+L Q++ + +IG
Sbjct: 441 EKADILLLRAGLPS----------HFHL----QLSEIEFHEIIG---------------- 470
Query: 248 SGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAV 307
SG + + V +K T+ CS+ + D+ E +L HP ++Q +
Sbjct: 471 SGSFGKVYKGRCRNKIVAIKRYRANTY--CSKSDV-DMFCREVSILCQLNHPCVIQFVGA 527
Query: 308 CLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLH--FQG 365
CL+ D + +V + I+ G+LFS+LHE++ +L ++ + + + ++ + YLH Q
Sbjct: 528 CLN-DPSQFAIVTQYISGGSLFSLLHEQKR---ILDLQSKLIIAVDVAKGMEYLHNLTQP 583
Query: 366 FIHRSLSSYAVHIISPGEARLTNL--EYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVIL 423
IHR L+S+ + + G A + + L+S D + ++T+ P + W APEV
Sbjct: 584 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLD---EDNMTKQPGNLR---WMAPEVFT 637
Query: 424 QKAA-TVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPY 478
Q T+K+D++S+++ + EILT +IP+ L K A + + +R P Y
Sbjct: 638 QCTRYTIKADVFSYALCLWEILTGEIPFAHL-----KPAAAAADMAYHHIRPPIGY 688
Score = 52.4 bits (124), Expect = 3e-06
Identities = 33/107 (30%), Positives = 52/107 (48%)
Query: 27 LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
LH V + N + +L G + V G TAL +A + G + DVL+ +G++ N +
Sbjct: 105 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 164
Query: 87 FDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAG 133
TP+H AA+ G++ + LL G D+ + E G P A G
Sbjct: 165 AVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 211
Score = 35.8 bits (81), Expect = 0.31
Identities = 25/108 (23%), Positives = 47/108 (43%)
Query: 34 GNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPV 93
G ++ ++ KG+ + G TAL +A + + L+ G+D + G T +
Sbjct: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
Query: 94 HAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAGKERSTQIV 141
H A +G+ LL G ++ + D P A G E+ T+++
Sbjct: 139 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/101 (25%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 27 LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
LH G+ +L+ G V+ +++ T L +AA G + +L+ +G+D N
Sbjct: 138 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 197
Query: 87 FDGSTPVHAAAFSGNQWILSKLLDAG--GDLRLHDERGQNP 125
G P+H A+ G I L++ G D+ D P
Sbjct: 198 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 238
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 80.9 bits (198), Expect = 8e-15
Identities = 102/416 (24%), Positives = 181/416 (43%), Gaps = 81/416 (19%)
Query: 83 NHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRL---------HDERGQNPKTWALTAG 133
NH+ DG T +H+A + G+ ++ LLD G D+ L ++ Q WA G
Sbjct: 435 NHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKG 494
Query: 134 KERSTQIVEFMQR------CASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCGGLVQGNP 187
+ +++ +R C + Q G SY V PS G +
Sbjct: 495 HDAIVTLLKHYKRPQDELPCNEYSQPGGDG-SY------------VSVPSPLGKIKSMTK 541
Query: 188 NGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADDEPTFSFF 247
+ LL+AG+ S F+L Q++ + +IG
Sbjct: 542 EKADILLLRAGLPS----------HFHL----QLSEIEFHEIIG---------------- 571
Query: 248 SGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAV 307
SG + + V +K T+ CS+ + D+ E +L HP ++Q +
Sbjct: 572 SGSFGKVYKGRCRNKIVAIKRYRANTY--CSKSDV-DMFCREVSILCQLNHPCVIQFVGA 628
Query: 308 CLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLH--FQG 365
CL+ D + +V + I+ G+LFS+LHE++ +L ++ + + + ++ + YLH Q
Sbjct: 629 CLN-DPSQFAIVTQYISGGSLFSLLHEQKR---ILDLQSKLIIAVDVAKGMEYLHNLTQP 684
Query: 366 FIHRSLSSYAVHIISPGEARLTNL--EYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVIL 423
IHR L+S+ + + G A + + L+S D + ++T+ P + W APEV
Sbjct: 685 IIHRDLNSHNILLYEDGHAVVADFGESRFLQSLD---EDNMTKQPGNLR---WMAPEVFT 738
Query: 424 QKAA-TVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPY 478
Q T+K+D++S+++ + EILT +IP+ L K A + + +R P Y
Sbjct: 739 QCTRYTIKADVFSYALCLWEILTGEIPFAHL-----KPAAAAADMAYHHIRPPIGY 789
Score = 52.4 bits (124), Expect = 3e-06
Identities = 33/107 (30%), Positives = 52/107 (48%)
Query: 27 LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
LH V + N + +L G + V G TAL +A + G + DVL+ +G++ N +
Sbjct: 206 LHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQD 265
Query: 87 FDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAG 133
TP+H AA+ G++ + LL G D+ + E G P A G
Sbjct: 266 AVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKG 312
Score = 35.8 bits (81), Expect = 0.31
Identities = 25/108 (23%), Positives = 47/108 (43%)
Query: 34 GNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPV 93
G ++ ++ KG+ + G TAL +A + + L+ G+D + G T +
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
Query: 94 HAAAFSGNQWILSKLLDAGGDLRLHDERGQNPKTWALTAGKERSTQIV 141
H A +G+ LL G ++ + D P A G E+ T+++
Sbjct: 240 HIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287
Score = 33.9 bits (76), Expect = 1.2
Identities = 26/101 (25%), Positives = 44/101 (43%), Gaps = 2/101 (1%)
Query: 27 LHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTALFVAALLGLRKFVDVLVDYGSDPNHRC 86
LH G+ +L+ G V+ +++ T L +AA G + +L+ +G+D N
Sbjct: 239 LHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSG 298
Query: 87 FDGSTPVHAAAFSGNQWILSKLLDAG--GDLRLHDERGQNP 125
G P+H A+ G I L++ G D+ D P
Sbjct: 299 EVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVP 339
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 77.8 bits (190), Expect = 7e-14
Identities = 62/250 (24%), Positives = 117/250 (46%), Gaps = 18/250 (7%)
Query: 248 SGPYMVMTNLVWNGSR-VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMA 306
SG + + +WN + V VK L + LR A ++ LRHP L+QL A
Sbjct: 242 SGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM-------KNLRHPKLIQLYA 294
Query: 307 VCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGF 366
VC +D ++ E + G+L L +H+ V + Q++ + YL + +
Sbjct: 295 VCTLED--PIYIITELMRHGSLQEYLQNDTGS--KIHLTQQVDMAAQVASGMAYLESRNY 350
Query: 367 IHRSLSSYAVHIISPGEARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQ 424
IHR L++ V + ++ + L + + ++ + + LP + W APE I
Sbjct: 351 IHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK---WTAPEAIRS 407
Query: 425 KAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIVK 483
++KSD++SF +++ EI+T +P+ G+ G+ V + + L P+ +Y+I+
Sbjct: 408 NKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIML 467
Query: 484 SGIHVKQKDR 493
+ + K+R
Sbjct: 468 ECWNAEPKER 477
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 74.7 bits (182), Expect = 6e-13
Identities = 55/204 (26%), Positives = 101/204 (49%), Gaps = 14/204 (6%)
Query: 282 LADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPV 341
L D L+AE +L +PY+++++ +C + E LV E +G L L + R
Sbjct: 390 LKDELLAEANVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYLQQNRH---- 442
Query: 342 LHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDRG 399
+ + I+ L+ Q+S ++YL F+HR L++ V +++ A++++ L L + D
Sbjct: 443 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA-DEN 501
Query: 400 VQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVV 458
+ T P + W APE I + KSD++SF ++M E + P++G+ GS V
Sbjct: 502 YYKAQTHGKWPVK---WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 558
Query: 459 KKAVVSGNYLEADVRLPKPYYDIV 482
+ G + P+ YD++
Sbjct: 559 TAMLEKGERMGCPAGCPREMYDLM 582
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 74.7 bits (182), Expect = 6e-13
Identities = 55/204 (26%), Positives = 101/204 (49%), Gaps = 14/204 (6%)
Query: 282 LADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPV 341
L D L+AE +L +PY+++++ +C + E LV E +G L L + R
Sbjct: 413 LKDELLAEANVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYLQQNRH---- 465
Query: 342 LHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDRG 399
+ + I+ L+ Q+S ++YL F+HR L++ V +++ A++++ L L + D
Sbjct: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA-DEN 524
Query: 400 VQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVV 458
+ T P + W APE I + KSD++SF ++M E + P++G+ GS V
Sbjct: 525 YYKAQTHGKWPVK---WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581
Query: 459 KKAVVSGNYLEADVRLPKPYYDIV 482
+ G + P+ YD++
Sbjct: 582 TAMLEKGERMGCPAGCPREMYDLM 605
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 73.6 bits (179), Expect = 1e-12
Identities = 68/234 (29%), Positives = 110/234 (47%), Gaps = 24/234 (10%)
Query: 259 WNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRL 318
W G V VK S A+ + E + L HP ++ L AVCL + L
Sbjct: 136 WRGELVAVKAARQDPDEDISVT--AESVRQEARLFAMLAHPNIIALKAVCLEEP--NLCL 191
Query: 319 VYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGF---IHRSLSSYA 375
V E G L L RR + V+V+ +QI+ + YLH + IHR L S
Sbjct: 192 VMEYAAGGPLSRALAGRR-----VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNN 246
Query: 376 VHIISPGEARLTNLEYM-LESEDRGVQRDLTRVPLPTQL-----YNWAAPEVILQKAATV 429
+ ++ P E+ ++E+ L+ D G+ R+ + TQ+ Y W APEVI +
Sbjct: 247 ILLLQPIES--DDMEHKTLKITDFGLAREWHKT---TQMSAAGTYAWMAPEVIKASTFSK 301
Query: 430 KSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAV-VSGNYLEADVRLPKPYYDIV 482
SD++SF +++ E+LT ++P++G+D V V V+ L P+P+ ++
Sbjct: 302 GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM 355
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 73.2 bits (178), Expect = 2e-12
Identities = 57/216 (26%), Positives = 110/216 (50%), Gaps = 23/216 (10%)
Query: 264 VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERI 323
V +K LN T P + + + LI + + HP+L++L+ VCLS ++ LV + +
Sbjct: 748 VAIKILNETTGPKANVEFMDEALIM-----ASMDHPHLVRLLGVCLSPTIQ---LVTQLM 799
Query: 324 TIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGE 383
G L +HE + + +++++ +QI+ + YL + +HR L++ V + SP
Sbjct: 800 PHGCLLEYVHEHKDN---IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH 856
Query: 384 ARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQ 441
++T+ L +LE +++ D ++P+ W A E I + T +SD++S+ + +
Sbjct: 857 VKITDFGLARLLEGDEKEYNADGGKMPI-----KWMALECIHYRKFTHQSDVWSYGVTIW 911
Query: 442 EILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKP 477
E++T K DG ++ + LE RLP+P
Sbjct: 912 ELMT--FGGKPYDGIPTREI---PDLLEKGERLPQP 942
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 73.2 bits (178), Expect = 2e-12
Identities = 57/216 (26%), Positives = 110/216 (50%), Gaps = 23/216 (10%)
Query: 264 VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERI 323
V +K LN T P + + + LI + + HP+L++L+ VCLS ++ LV + +
Sbjct: 748 VAIKILNETTGPKANVEFMDEALIM-----ASMDHPHLVRLLGVCLSPTIQ---LVTQLM 799
Query: 324 TIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGE 383
G L +HE + + +++++ +QI+ + YL + +HR L++ V + SP
Sbjct: 800 PHGCLLEYVHEHKDN---IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH 856
Query: 384 ARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQ 441
++T+ L +LE +++ D ++P+ W A E I + T +SD++S+ + +
Sbjct: 857 VKITDFGLARLLEGDEKEYNADGGKMPI-----KWMALECIHYRKFTHQSDVWSYGVTIW 911
Query: 442 EILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKP 477
E++T K DG ++ + LE RLP+P
Sbjct: 912 ELMT--FGGKPYDGIPTREI---PDLLEKGERLPQP 942
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 73.2 bits (178), Expect = 2e-12
Identities = 55/214 (25%), Positives = 93/214 (43%), Gaps = 13/214 (6%)
Query: 291 EHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHL 350
+H KL+HP ++ VC ++ E G L+ VL R P L +V
Sbjct: 206 KHLRKLKHPNIIAFKGVCTQAPCYC--IIMEYCAHGQLYEVLRAGRKITPRL----LVDW 259
Query: 351 LLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLP 410
I+ + YLH IHR L S V + ++++ E D+ +
Sbjct: 260 STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVA- 318
Query: 411 TQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGN-YLE 469
W APEVI + + K DI+SF +++ E+LT +IP+K +D S + V S + +L
Sbjct: 319 -----WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 373
Query: 470 ADVRLPKPYYDIVKSGIHVKQKDRTMNLQDIRYI 503
P + ++K K ++R Q + ++
Sbjct: 374 VPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHL 407
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 72.4 bits (176), Expect = 3e-12
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 17/197 (8%)
Query: 281 RLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFP 340
++ DL + +H KL+HP ++ VC ++ E G L+ VL R P
Sbjct: 153 KVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYC--ILMEFCAQGQLYEVLRAGRPVTP 210
Query: 341 VLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGV 400
L +V + I+ + YLH IHR L S + I ++++ E D+
Sbjct: 211 SL----LVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKST 266
Query: 401 QRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKK 460
+ W APEVI + + K DI+SF +++ E+LT +IP+K +D S +
Sbjct: 267 KMSFAGTVA------WMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIW 320
Query: 461 AVVSGNYLEADVRLPKP 477
V S + + LP P
Sbjct: 321 GVGSNS-----LHLPVP 332
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 72.0 bits (175), Expect = 4e-12
Identities = 70/254 (27%), Positives = 112/254 (44%), Gaps = 25/254 (9%)
Query: 248 SGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAV 307
+G + + W G V VK P A+ + E + LRHP +++L V
Sbjct: 132 AGGFGQVYRATWQGQEVAVKAAR--QDPEQDAAAAAESVRREARLFAMLRHPNIIELRGV 189
Query: 308 CLSQDLEKTRLVYERITIGTLFSVLHE------------RRSQFPVLHMEVIVHLLLQIS 355
CL Q LV E G L L RR++ H V+V+ +QI+
Sbjct: 190 CLQQP--HLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPH--VLVNWAVQIA 245
Query: 356 DALRYLHFQGFI---HRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQ 412
+ YLH + F+ HR L S + ++ E L+ D G+ R+ R +
Sbjct: 246 RGMLYLHEEAFVPILHRDLKSSNILLLEKIEHD-DICNKTLKITDFGLAREWHRTTKMST 304
Query: 413 L--YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAV-VSGNYLE 469
Y W APEVI + SDI+S+ +++ E+LT ++P++G+DG V V V+ L
Sbjct: 305 AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP 364
Query: 470 ADVRLPKPYYDIVK 483
P+P+ ++K
Sbjct: 365 IPSTCPEPFAKLMK 378
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 72.0 bits (175), Expect = 4e-12
Identities = 64/232 (27%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 259 WNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRL 318
W G V VK S+ + + E + + L+HP ++ L VCL + L
Sbjct: 163 WIGDEVAVKAARHDPDEDISQT--IENVRQEAKLFAMLKHPNIIALRGVCLKEP--NLCL 218
Query: 319 VYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGF---IHRSLSSYA 375
V E G L VL +R + +++V+ +QI+ + YLH + IHR L S
Sbjct: 219 VMEFARGGPLNRVLSGKR-----IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSN 273
Query: 376 VHIISPGE-ARLTNLEYMLESEDRGVQRDLTRVPLPTQL--YNWAAPEVILQKAATVKSD 432
+ I+ E L+N +L+ D G+ R+ R + Y W APEVI + SD
Sbjct: 274 ILILQKVENGDLSNK--ILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSD 331
Query: 433 IYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNY-LEADVRLPKPYYDIVK 483
++S+ +++ E+LT ++P++G+DG V V L P+P+ +++
Sbjct: 332 VWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLME 383
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 71.2 bits (173), Expect = 7e-12
Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 12/217 (5%)
Query: 283 ADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVL 342
A +AE ++LRH L+QL+ V + ++ +V E + G+L L R VL
Sbjct: 230 AQAFLAEASVMTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRS--VL 286
Query: 343 HMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQR 402
+ ++ L + +A+ YL F+HR L++ V + A++++ E+ +
Sbjct: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---Q 343
Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
D ++P+ W APE + +K + KSD++SF +++ EI + +P+ + V
Sbjct: 344 DTGKLPV-----KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398
Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQ 498
V G ++A P Y+++K+ H+ R LQ
Sbjct: 399 VEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 71.2 bits (173), Expect = 7e-12
Identities = 55/217 (25%), Positives = 104/217 (47%), Gaps = 12/217 (5%)
Query: 283 ADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVL 342
A +AE ++LRH L+QL+ V + ++ +V E + G+L L R VL
Sbjct: 230 AQAFLAEASVMTQLRHSNLVQLLGVIV-EEKGGLYIVTEYMAKGSLVDYLRSRGRS--VL 286
Query: 343 HMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQR 402
+ ++ L + +A+ YL F+HR L++ V + A++++ E+ +
Sbjct: 287 GGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASST---Q 343
Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
D ++P+ W APE + +K + KSD++SF +++ EI + +P+ + V
Sbjct: 344 DTGKLPV-----KWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPR 398
Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQ 498
V G ++A P Y+++K+ H+ R LQ
Sbjct: 399 VEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQ 435
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 70.5 bits (171), Expect = 1e-11
Identities = 56/212 (26%), Positives = 105/212 (49%), Gaps = 15/212 (7%)
Query: 286 LIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHME 345
++ E + +L +PY+++L+ VC ++ L LV E G L L +R + PV ++
Sbjct: 76 MMREAQIMHQLDNPYIVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREEIPVSNVA 132
Query: 346 VIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDR-GVQR 402
++H Q+S ++YL + F+HR L++ V +++ A++++ L L ++D R
Sbjct: 133 ELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 189
Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
+ PL W APE I + + +SD++S+ + M E L+ P+K + G V
Sbjct: 190 SAGKWPL-----KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 244
Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDR 493
+ G +E P Y ++ K +DR
Sbjct: 245 IEQGKRMECPPECPPELYALMSDCWIYKWEDR 276
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 70.5 bits (171), Expect = 1e-11
Identities = 56/212 (26%), Positives = 105/212 (49%), Gaps = 15/212 (7%)
Query: 286 LIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHME 345
++ E + +L +PY+++L+ VC ++ L LV E G L L +R + PV ++
Sbjct: 383 MMREAQIMHQLDNPYIVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREEIPVSNVA 439
Query: 346 VIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDR-GVQR 402
++H Q+S ++YL + F+HR L++ V +++ A++++ L L ++D R
Sbjct: 440 ELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496
Query: 403 DLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKA 461
+ PL W APE I + + +SD++S+ + M E L+ P+K + G V
Sbjct: 497 SAGKWPL-----KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551
Query: 462 VVSGNYLEADVRLPKPYYDIVKSGIHVKQKDR 493
+ G +E P Y ++ K +DR
Sbjct: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDR 583
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 70.1 bits (170), Expect = 1e-11
Identities = 52/205 (25%), Positives = 98/205 (47%), Gaps = 19/205 (9%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQI 354
+++HP L+QL+ VC + ++ E +T G L L E Q ++ V++++ QI
Sbjct: 292 EIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQ--EVNAVVLLYMATQI 347
Query: 355 SDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL- 413
S A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 348 SSAMEYLEKKNFIHRDLAARNC---------LVGENHLVKVADFGLSRLMTGDTYTAHAG 398
Query: 414 ----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNYL 468
W APE + ++KSD+++F +++ EI T + P+ G+D S V + + +
Sbjct: 399 AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM 458
Query: 469 EADVRLPKPYYDIVKSGIHVKQKDR 493
E P+ Y+++++ DR
Sbjct: 459 ERPEGCPEKVYELMRACWQWNPSDR 483
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 70.1 bits (170), Expect = 1e-11
Identities = 52/205 (25%), Positives = 98/205 (47%), Gaps = 19/205 (9%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQI 354
+++HP L+QL+ VC + ++ E +T G L L E Q ++ V++++ QI
Sbjct: 311 EIKHPNLVQLLGVCTREP--PFYIITEFMTYGNLLDYLRECNRQ--EVNAVVLLYMATQI 366
Query: 355 SDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL- 413
S A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 367 SSAMEYLEKKNFIHRDLAARNC---------LVGENHLVKVADFGLSRLMTGDTYTAHAG 417
Query: 414 ----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNYL 468
W APE + ++KSD+++F +++ EI T + P+ G+D S V + + +
Sbjct: 418 AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM 477
Query: 469 EADVRLPKPYYDIVKSGIHVKQKDR 493
E P+ Y+++++ DR
Sbjct: 478 ERPEGCPEKVYELMRACWQWNPSDR 502
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 70.1 bits (170), Expect = 1e-11
Identities = 64/228 (28%), Positives = 101/228 (44%), Gaps = 18/228 (7%)
Query: 258 VWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTR 317
+W G V VK L P A+ + E L+HP ++ L CL+
Sbjct: 116 LWRGEEVAVKAARLD--PEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPP--HLC 171
Query: 318 LVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQG---FIHRSLSSY 374
LV E G L VL RR + V+V+ +Q++ + YLH IHR L S
Sbjct: 172 LVMEYARGGALSRVLAGRR-----VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSI 226
Query: 375 AVHIISPGEARLTNL-EYMLESEDRGVQRDLTRVPLPTQL--YNWAAPEVILQKAATVKS 431
+ I+ E NL + +L+ D G+ R+ + + Y W APEVI + S
Sbjct: 227 NILILEAIENH--NLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSS 284
Query: 432 DIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNY-LEADVRLPKPY 478
D++SF +++ E+LT ++P++ +D V V L P+P+
Sbjct: 285 DVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPF 332
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 69.3 bits (168), Expect = 3e-11
Identities = 56/211 (26%), Positives = 101/211 (47%), Gaps = 16/211 (7%)
Query: 287 IAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEV 346
I E + KL H L+QL VC+ + + +V E + G L + L E + + L E+
Sbjct: 312 IEEAKVMMKLSHSKLVQLYGVCIQR--KPLYIVTEFMENGCLLNYLRENKGK---LRKEM 366
Query: 347 IVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNL---EYMLESEDRGVQRD 403
++ + I + + YL G+IHR L++ + S ++++ Y+L+ D V
Sbjct: 367 LLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLD--DEYVSSF 424
Query: 404 LTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQEILTD-DIPWKGLDGSVVKKAV 462
+ P+ W+ PEV L + KSD++SF ++M E+ T+ +P++ V +A+
Sbjct: 425 GAKFPI-----KWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAI 479
Query: 463 VSGNYLEADVRLPKPYYDIVKSGIHVKQKDR 493
G L P Y+++ S H K + R
Sbjct: 480 SEGFRLYRPHLAPMSIYEVMYSCWHEKPEGR 510
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 68.9 bits (167), Expect = 3e-11
Identities = 62/235 (26%), Positives = 106/235 (45%), Gaps = 31/235 (13%)
Query: 289 EQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLH------------ERR 336
E E + L+H ++++ VC D + +V+E + G L L + R
Sbjct: 588 EAELLTNLQHEHIVKFYGVC--GDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPR 645
Query: 337 SQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESE 396
L + ++H+ QI+ + YL Q F+HR L++ L +++
Sbjct: 646 QAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNC---------LVGANLLVKIG 696
Query: 397 DRGVQRDLT-----RVPLPTQL-YNWAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIP 449
D G+ RD+ RV T L W PE I+ + T +SD++SF +I+ EI T P
Sbjct: 697 DFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP 756
Query: 450 WKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIVKSGIHVKQKDRTMNLQDIRYIL 504
W L + V + + G LE PK YD++ G ++ + +N+++I IL
Sbjct: 757 WFQLSNTEVIECITQGRVLERPRVCPKEVYDVM-LGCWQREPQQRLNIKEIYKIL 810
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 67.8 bits (164), Expect = 7e-11
Identities = 50/217 (23%), Positives = 109/217 (50%), Gaps = 25/217 (11%)
Query: 264 VTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPYLLQLMAVCLSQDLEKTRLVYERI 323
V +KEL T P ++ L + + + + +P++ +L+ +CL+ ++ L+ + +
Sbjct: 742 VAIKELREATSPKANKEILDEAYVM-----ASVDNPHVCRLLGICLTSTVQ---LITQLM 793
Query: 324 TIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRYLHFQGFIHRSLSSYAVHIISPGE 383
G L + E + + + +++ +QI+ + YL + +HR L++ V + +P
Sbjct: 794 PFGCLLDYVREHKDN---IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH 850
Query: 384 ARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVILQKAATVKSDIYSFSMIMQ 441
++T+ L +L +E++ + +VP+ W A E IL + T +SD++S+ + +
Sbjct: 851 VKITDFGLAKLLGAEEKEYHAEGGKVPI-----KWMALESILHRIYTHQSDVWSYGVTVW 905
Query: 442 EILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRLPKP 477
E++T P+ G+ S + + LE RLP+P
Sbjct: 906 ELMTFGSKPYDGIPASEI------SSILEKGERLPQP 936
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 67.0 bits (162), Expect = 1e-10
Identities = 49/190 (25%), Positives = 92/190 (48%), Gaps = 13/190 (6%)
Query: 298 HPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDA 357
HP++L L V + + ++ E + G L + L ER Q L +V +L I+
Sbjct: 682 HPHILHLEGVVTKR--KPIMIITEFMENGALDAFLREREDQ---LVPGQLVAMLQGIASG 736
Query: 358 LRYLHFQGFIHRSLSSYAVHIISPGEARLTN--LEYMLESEDRGVQRDLTRVPLPTQLYN 415
+ YL ++HR L++ + + ++++ L +L+ D + ++P+
Sbjct: 737 MNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPI-----R 791
Query: 416 WAAPEVILQKAATVKSDIYSFSMIMQEILT-DDIPWKGLDGSVVKKAVVSGNYLEADVRL 474
W APE I + T SD++SF ++M E+L+ D P+ + V K++ G L V
Sbjct: 792 WTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDC 851
Query: 475 PKPYYDIVKS 484
P P Y+++K+
Sbjct: 852 PAPLYELMKN 861
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 67.0 bits (162), Expect = 1e-10
Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
+++HP L+QL+ VC + +V E + G L L E R + + V++++ Q
Sbjct: 323 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 377
Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
IS A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 428
Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
W APE + ++KSD+++F +++ EI T + P+ G+D S V + G
Sbjct: 429 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 488
Query: 468 LEADVRLPKPYYDIVKS 484
+E P Y+++++
Sbjct: 489 MEQPEGCPPKVYELMRA 505
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 67.0 bits (162), Expect = 1e-10
Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
+++HP L+QL+ VC + +V E + G L L E R + + V++++ Q
Sbjct: 338 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 392
Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
IS A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 393 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 443
Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
W APE + ++KSD+++F +++ EI T + P+ G+D S V + G
Sbjct: 444 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 503
Query: 468 LEADVRLPKPYYDIVKS 484
+E P Y+++++
Sbjct: 504 MEQPEGCPPKVYELMRA 520
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 67.0 bits (162), Expect = 1e-10
Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
+++HP L+QL+ VC + +V E + G L L E R + + V++++ Q
Sbjct: 317 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 371
Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
IS A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 372 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 422
Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
W APE + ++KSD+++F +++ EI T + P+ G+D S V + G
Sbjct: 423 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 482
Query: 468 LEADVRLPKPYYDIVKS 484
+E P Y+++++
Sbjct: 483 MEQPEGCPPKVYELMRA 499
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 67.0 bits (162), Expect = 1e-10
Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
+++HP L+QL+ VC + +V E + G L L E R + + V++++ Q
Sbjct: 323 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 377
Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
IS A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 378 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 428
Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
W APE + ++KSD+++F +++ EI T + P+ G+D S V + G
Sbjct: 429 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 488
Query: 468 LEADVRLPKPYYDIVKS 484
+E P Y+++++
Sbjct: 489 MEQPEGCPPKVYELMRA 505
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 67.0 bits (162), Expect = 1e-10
Identities = 51/197 (25%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 295 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHE-RRSQFPVLHMEVIVHLLLQ 353
+++HP L+QL+ VC + +V E + G L L E R + + V++++ Q
Sbjct: 302 EIKHPNLVQLLGVCTLEP--PFYIVTEYMPYGNLLDYLRECNREEVTAV---VLLYMATQ 356
Query: 354 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL 413
IS A+ YL + FIHR L++ L ++++ D G+ R +T
Sbjct: 357 ISSAMEYLEKKNFIHRDLAARNC---------LVGENHVVKVADFGLSRLMTGDTYTAHA 407
Query: 414 -----YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDI-PWKGLDGSVVKKAVVSGNY 467
W APE + ++KSD+++F +++ EI T + P+ G+D S V + G
Sbjct: 408 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 467
Query: 468 LEADVRLPKPYYDIVKS 484
+E P Y+++++
Sbjct: 468 MEQPEGCPPKVYELMRA 484
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,687,072
Number of Sequences: 37866
Number of extensions: 2993224
Number of successful extensions: 13962
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 420
Number of HSP's successfully gapped in prelim test: 721
Number of HSP's that attempted gapping in prelim test: 10457
Number of HSP's gapped (non-prelim): 3689
length of query: 1451
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1336
effective length of database: 13,892,928
effective search space: 18560951808
effective search space used: 18560951808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.