Search of human proteins with 57768564

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|57768564 hypothetical protein LOC23281 isoform b [Homo
sapiens]
         (348 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens]    686   0.0  
gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens]   640   0.0  
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap...   219   2e-57
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap...   219   2e-57
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap...   219   2e-57
gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo sap...   219   2e-57
gi|45935391 coiled-coil domain containing 69 [Homo sapiens]           137   1e-32
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    76   4e-14
gi|221139761 zinc finger protein 853 [Homo sapiens]                    73   3e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     73   3e-13
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap...    73   4e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    72   6e-13
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        72   7e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        72   7e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         72   7e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         72   7e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         72   7e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         72   7e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         72   7e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         72   7e-13
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         71   2e-12
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         71   2e-12
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 70   2e-12
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    70   3e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    70   4e-12
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    69   6e-12
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    69   6e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    69   6e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    69   8e-12
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    69   8e-12

>gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens]
          Length = 348

 Score =  686 bits (1769), Expect = 0.0
 Identities = 348/348 (100%), Positives = 348/348 (100%)

Query: 1   MGHCCCKPYNCLQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERR 60
           MGHCCCKPYNCLQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERR
Sbjct: 1   MGHCCCKPYNCLQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERR 60

Query: 61  FEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASH 120
           FEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASH
Sbjct: 61  FEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASH 120

Query: 121 DAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTF 180
           DAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTF
Sbjct: 121 DAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTF 180

Query: 181 QSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKIL 240
           QSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKIL
Sbjct: 181 QSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKIL 240

Query: 241 ELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
           ELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR
Sbjct: 241 ELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300

Query: 301 LSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR 348
           LSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR
Sbjct: 301 LSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR 348


>gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens]
          Length = 1379

 Score =  640 bits (1652), Expect = 0.0
 Identities = 330/332 (99%), Positives = 331/332 (99%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL 76
            + NESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL
Sbjct: 1048 RKNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL 1107

Query: 77   QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT 136
            QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT
Sbjct: 1108 QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT 1167

Query: 137  ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 196
            ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL
Sbjct: 1168 ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 1227

Query: 197  RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKI 256
            RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKI
Sbjct: 1228 RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKI 1287

Query: 257  QVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGD 316
            QVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGD
Sbjct: 1288 QVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGD 1347

Query: 317  PTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR 348
            PTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR
Sbjct: 1348 PTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR 1379


>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
           sapiens]
          Length = 436

 Score =  219 bits (559), Expect = 2e-57
 Identities = 125/332 (37%), Positives = 206/332 (62%), Gaps = 12/332 (3%)

Query: 12  LQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQ 71
           +Q L    E AL + K LS EL N+R E+   +  CEKL+K + EL+  +E  V+    Q
Sbjct: 106 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----Q 161

Query: 72  QQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
            QAE  E E RL+  +  E  +L++ + ++    + Q QEQ ++L A+H+ + LE+E +H
Sbjct: 162 HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 221

Query: 132 TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
           +  + +L+  ++  + E+   HE+EKK LE+   + + SL+ Q++ L  ++ +L ++ + 
Sbjct: 222 SEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 281

Query: 192 FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
            E+  ++   E+  +      +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N  
Sbjct: 282 EEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 339

Query: 252 LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
           L +K++  QQ+NE+LKAR+D++  ++RQLS E A LQE +EKE++  KRLS  NEELLWK
Sbjct: 340 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 399

Query: 312 LQTGDPTSPIKLSPTSPVY-----RGSSSGPS 338
           L  GD  SP K SPTS        R S S PS
Sbjct: 400 LHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 430


>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sapiens]
          Length = 1270

 Score =  219 bits (559), Expect = 2e-57
 Identities = 125/332 (37%), Positives = 206/332 (62%), Gaps = 12/332 (3%)

Query: 12   LQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQ 71
            +Q L    E AL + K LS EL N+R E+   +  CEKL+K + EL+  +E  V+    Q
Sbjct: 940  IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----Q 995

Query: 72   QQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
             QAE  E E RL+  +  E  +L++ + ++    + Q QEQ ++L A+H+ + LE+E +H
Sbjct: 996  HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 1055

Query: 132  TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
            +  + +L+  ++  + E+   HE+EKK LE+   + + SL+ Q++ L  ++ +L ++ + 
Sbjct: 1056 SEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 1115

Query: 192  FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
             E+  ++   E+  +      +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N  
Sbjct: 1116 EEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 1173

Query: 252  LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
            L +K++  QQ+NE+LKAR+D++  ++RQLS E A LQE +EKE++  KRLS  NEELLWK
Sbjct: 1174 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 1233

Query: 312  LQTGDPTSPIKLSPTSPVY-----RGSSSGPS 338
            L  GD  SP K SPTS        R S S PS
Sbjct: 1234 LHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 1264


>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sapiens]
          Length = 1216

 Score =  219 bits (559), Expect = 2e-57
 Identities = 125/332 (37%), Positives = 206/332 (62%), Gaps = 12/332 (3%)

Query: 12   LQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQ 71
            +Q L    E AL + K LS EL N+R E+   +  CEKL+K + EL+  +E  V+    Q
Sbjct: 886  IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----Q 941

Query: 72   QQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
             QAE  E E RL+  +  E  +L++ + ++    + Q QEQ ++L A+H+ + LE+E +H
Sbjct: 942  HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 1001

Query: 132  TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
            +  + +L+  ++  + E+   HE+EKK LE+   + + SL+ Q++ L  ++ +L ++ + 
Sbjct: 1002 SEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 1061

Query: 192  FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
             E+  ++   E+  +      +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N  
Sbjct: 1062 EEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 1119

Query: 252  LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
            L +K++  QQ+NE+LKAR+D++  ++RQLS E A LQE +EKE++  KRLS  NEELLWK
Sbjct: 1120 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 1179

Query: 312  LQTGDPTSPIKLSPTSPVY-----RGSSSGPS 338
            L  GD  SP K SPTS        R S S PS
Sbjct: 1180 LHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 1210


>gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
           sapiens]
          Length = 517

 Score =  219 bits (559), Expect = 2e-57
 Identities = 125/332 (37%), Positives = 206/332 (62%), Gaps = 12/332 (3%)

Query: 12  LQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQ 71
           +Q L    E AL + K LS EL N+R E+   +  CEKL+K + EL+  +E  V+    Q
Sbjct: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----Q 242

Query: 72  QQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
            QAE  E E RL+  +  E  +L++ + ++    + Q QEQ ++L A+H+ + LE+E +H
Sbjct: 243 HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 302

Query: 132 TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
           +  + +L+  ++  + E+   HE+EKK LE+   + + SL+ Q++ L  ++ +L ++ + 
Sbjct: 303 SEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 362

Query: 192 FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
            E+  ++   E+  +      +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N  
Sbjct: 363 EEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 420

Query: 252 LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
           L +K++  QQ+NE+LKAR+D++  ++RQLS E A LQE +EKE++  KRLS  NEELLWK
Sbjct: 421 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 480

Query: 312 LQTGDPTSPIKLSPTSPVY-----RGSSSGPS 338
           L  GD  SP K SPTS        R S S PS
Sbjct: 481 LHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 511


>gi|45935391 coiled-coil domain containing 69 [Homo sapiens]
          Length = 296

 Score =  137 bits (345), Expect = 1e-32
 Identities = 84/282 (29%), Positives = 158/282 (56%), Gaps = 2/282 (0%)

Query: 49  KLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQ 108
           +L   K   ++R E E ++    +  EL  L     +  +   +   E H   +  I  Q
Sbjct: 7   RLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQ 66

Query: 109 HQEQVEDLTASHDAAL-LEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKL 167
           H+E+ +      +    LE+ +       +L+  ++  +Q L +++E EK+ L  +F + 
Sbjct: 67  HEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREA 126

Query: 168 RLSLQDQVDTLTFQSQSLRDRARRFEEA-LRKNTEEQLEIALAPYQHLEEDMKSLKQVLE 226
             + Q+ +D LT Q ++ + + +R EE+ L +N ++ ++   +P Q  E++++SL  V+E
Sbjct: 127 SSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIE 186

Query: 227 MKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENAN 286
           MKN++IHE +++++ +E + EKN+ILEEKI  LQQ+NEDL  R     V++RQLSE+   
Sbjct: 187 MKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLL 246

Query: 287 LQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSP 328
            +E +EKE Q +++L +  EELL+++   + +    L+P +P
Sbjct: 247 TREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTP 288


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 66/295 (22%), Positives = 144/295 (48%), Gaps = 22/295 (7%)

Query: 17  KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL 76
           +  E    +E+++  +   IR++      + E++  EKEE  RR E+ +    W+++ ++
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEE-KMRRQEEMMWEKEEKMRRQEEMM----WEKEEKI 346

Query: 77  QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT 136
           +ELEE++    E E  R QEE   +   IR Q + Q ++      A +   E        
Sbjct: 347 RELEEKMH---EQEKIREQEEKRQEEEKIREQEKRQEQE------AKMWRQEEKIRE--- 394

Query: 137 ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 196
             Q++   + +E+M   E +  E EE   +    +Q+Q + +  Q + +R++ ++  E  
Sbjct: 395 --QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQE 452

Query: 197 RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQ--IHEQEKKILELEK-LAEKNIILE 253
            K  E++  +     +  E++ K  +Q  +M+ Q+  +  QE+KI E EK + E+   + 
Sbjct: 453 EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512

Query: 254 EKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           E+ +++Q+Q E +  + ++      ++ E+   ++   EK  +++ RL +  E++
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 63/291 (21%), Positives = 138/291 (47%), Gaps = 29/291 (9%)

Query: 23  LVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEER 82
           L+ +++L  E  ++  E+   +AK +  Q E+ EL  R   + +   W+Q+ ++QE EE+
Sbjct: 245 LLPQQQLQAEADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEREEK 303

Query: 83  LQLQFEAEMARLQEEHGDQLLSIRCQHQEQV---EDLTASHDAALLEMENNHTVAITILQ 139
           +Q Q   E  R QEE   +   +  + +E++   E++    +  + E+E           
Sbjct: 304 IQEQ--EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE---------- 351

Query: 140 DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALR 197
                K+ E     E E+K  EE   + +   Q+Q   +  Q + +R++  +   +E + 
Sbjct: 352 -----KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406

Query: 198 KNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQ 257
           +  EE++          EE+M+  ++ +  + ++I EQEKKI E E+       + E+ +
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK------IREQEE 460

Query: 258 VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           ++Q+Q E +  +  +      ++ E+   ++   EK  +++K++    E++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 52/219 (23%), Positives = 110/219 (50%), Gaps = 18/219 (8%)

Query: 48  EKLQKEKE--ELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSI 105
           EK Q+E++  E E+R E E K   W+Q+ +++E EE+++ Q E  M   +E+ G+Q   +
Sbjct: 364 EKRQEEEKIREQEKRQEQEAKM--WRQEEKIREQEEKIREQ-EEMMQEQEEKMGEQEEKM 420

Query: 106 RCQHQE--QVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEEN 163
             Q +E  + E+     +  + E E          Q++   + +E+M   E +  E E  
Sbjct: 421 WEQEEEMQEQEEKMRRQEEKIREQEKKIRE-----QEEKIREQEEMMQEQEEKMGEQEGK 475

Query: 164 FEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQ 223
             +    +Q+Q + +  Q + +R++ ++  E   K  E++        Q  EE M   ++
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE-----EMMQEQEEKMWEQEE 530

Query: 224 VLEMKNQQIHEQEKKI-LELEKLAEKNIILEEKIQVLQQ 261
            +  + +++ EQE+K+  + EK+ E+ + L ++ + +Q+
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 41/164 (25%), Positives = 75/164 (45%), Gaps = 23/164 (14%)

Query: 154 ELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQH 213
           E E+K   ++ E LR  L+ QV T+                  R  T ++ E+ +A Y +
Sbjct: 96  EDEQKASHQHQEALRRELEAQVQTI------------------RILTCQKTELQMALY-Y 136

Query: 214 LEEDMKSLKQVLEMKNQQIHEQEKKILELEK----LAEKNIILEEKIQVLQQQNEDLKAR 269
            +  +K L+        ++H+  K   ELE+    +A +    +  I+ L ++ + L   
Sbjct: 137 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 196

Query: 270 IDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
           + +NT+   +L E+NA LQE ++    EK  +    +EL  KL+
Sbjct: 197 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 240


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 71/323 (21%), Positives = 152/323 (47%), Gaps = 41/323 (12%)

Query: 49  KLQKEKEEL--ERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIR 106
           +LQ+EK +    +  + E++ +  QQQ + Q+++E+ +LQ + E  + Q+    Q+L  +
Sbjct: 132 QLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQ 191

Query: 107 CQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEK 166
            Q Q+QV+      +  LL+ +        +LQ     + Q+     + ++++L++  + 
Sbjct: 192 EQLQQQVQ------EQQLLQQQQEQLQQQQLLQQQEQLQQQQF----QQQQEQLQQQQQL 241

Query: 167 LRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLE 226
           L L  Q Q+     Q Q L+ +  + ++ L +  + QL+  L   Q  +   +  +Q+L+
Sbjct: 242 LLLQQQGQL-----QQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQ 296

Query: 227 MKNQQIHEQEKKILELEKLAEKNIILE------EKIQVLQQQNEDLK-----ARIDQNTV 275
            + +Q+ +Q+ +   LE   E+ + LE         Q L+QQ ++L+      R  +   
Sbjct: 297 QQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQ 356

Query: 276 VTRQLSEENANLQEYVEKETQEKKR-----------LSRTNEELLWKLQTGDPTSPIKLS 324
           +  +L EE   L++ +E++ Q+ ++           L    +E+  +L    P   ++L 
Sbjct: 357 LQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELV 416

Query: 325 PTSPVYRGSSSGPSSPARVSTTP 347
           P +    G ++ P +PA V   P
Sbjct: 417 PAAG--GGGAAVPGAPAAVVVAP 437



 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 53/249 (21%), Positives = 123/249 (49%), Gaps = 26/249 (10%)

Query: 71  QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
           Q++ +LQ+LE++ + Q + +  +LQ+        +  Q Q Q +        + L+ E +
Sbjct: 86  QRELQLQQLEQQPEPQQQPQHEQLQQPQP----HLELQQQPQQD---GQQQLSQLQQEKH 138

Query: 131 HTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRL-SLQDQVDTLTFQSQSLRDRA 189
            +V        H     EL   H+ ++ + ++  E+ RL   Q+Q+ T   Q Q +  + 
Sbjct: 139 QSV-------HHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQ- 190

Query: 190 RRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKN 249
              +E L++  +EQ    L   Q   +  + L+Q  +++ QQ  +Q++++ + ++L    
Sbjct: 191 ---QEQLQQQVQEQQ--LLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQL---- 241

Query: 250 IILEEKIQVLQQQNEDLKARIDQNTVVTRQLS-EENANLQEYVEKETQEKKRLSRTNEEL 308
           ++L+++ Q+ QQ  +  +A++ Q  +  +Q   ++   LQ+  + + Q++++L +  +E 
Sbjct: 242 LLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQ 301

Query: 309 LWKLQTGDP 317
           L + Q   P
Sbjct: 302 LQQQQLQPP 310



 Score = 35.4 bits (80), Expect = 0.076
 Identities = 28/106 (26%), Positives = 56/106 (52%), Gaps = 9/106 (8%)

Query: 25  KEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQ 84
           +E+E+ +EL  +           ++L+++++ELER+ E E ++   Q Q +LQE  ++L+
Sbjct: 316 EEEEVELELMPV------DLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLE 369

Query: 85  LQFEAEMARLQEEHGDQLLS---IRCQHQEQVEDLTASHDAALLEM 127
            Q E +  +L+++     L+   +  Q QE   +LT       LE+
Sbjct: 370 QQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLEL 415


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 88/329 (26%), Positives = 155/329 (47%), Gaps = 43/329 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQ------Q 73
            +  L  E EL  E   +R  +   TAK ++L++   +LE R E+E +R    Q      Q
Sbjct: 886  QEQLQAETELCAEAEELRARL---TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942

Query: 74   AELQELEERLQ-------------LQFEAEMARLQEEH---GDQLLSIRCQHQEQVEDLT 117
              +QELEE+L+             +  EA++ +L+EE     DQ   +  + ++ +ED  
Sbjct: 943  QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL-AKEKKLLEDRI 1001

Query: 118  ASHDAALLEMENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLR---LSL 171
            A     L E E   + ++  L++ H+  +   +E +   E +++ELE+   KL      L
Sbjct: 1002 AEFTTNLTE-EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

Query: 172  QDQVDTLTFQSQSLRDRARRFEE----ALRKNTEE--QLEIALAPYQHLEEDMKSLKQVL 225
             DQ+  L  Q   L+ +  + EE    AL +  EE  Q  +AL   + LE  +  L++ L
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 226  EMKNQQIHEQEKKILEL-EKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEEN 284
            E +    ++ EK+  +L E+L      LE+ +     Q E L+++ +Q   + ++  EE 
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE-LRSKREQEVNILKKTLEEE 1179

Query: 285  ANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
            A   E   +E ++K   S+  EEL  +L+
Sbjct: 1180 AKTHEAQIQEMRQKH--SQAVEELAEQLE 1206



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 76/325 (23%), Positives = 138/325 (42%), Gaps = 38/325 (11%)

Query: 22   ALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLG--WQQQAELQEL 79
            AL K +EL  +++ +++++    A   K +K+K +L    E     L       A  QEL
Sbjct: 1102 ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161

Query: 80   EERLQLQFEAEMARLQEE---HGDQLLSIRCQHQEQVEDLT----------ASHDAALLE 126
              + + +       L+EE   H  Q+  +R +H + VE+L           A+ + A   
Sbjct: 1162 RSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT 1221

Query: 127  MEN------NHTVAITILQDDHDHK-------VQELM---STHELEKKELEENFEKLRLS 170
            +EN      N    +   + D +HK       +QEL    +  E  + EL +   KL++ 
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVE 1281

Query: 171  LQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKN- 229
            L D V  L  QS S   +  +   AL    ++  E+     +        LKQV + KN 
Sbjct: 1282 L-DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340

Query: 230  --QQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANL 287
              +Q+ E+E+    LEK   +   L  ++  ++++ ED    ++    V R+L ++   L
Sbjct: 1341 FREQLEEEEEAKHNLEK---QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGL 1397

Query: 288  QEYVEKETQEKKRLSRTNEELLWKL 312
             +  E++     +L +T   L  +L
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQEL 1422



 Score = 55.8 bits (133), Expect = 5e-08
 Identities = 66/311 (21%), Positives = 138/311 (44%), Gaps = 29/311 (9%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQ-E 78
            E+A   +++L  +L  +        A  +KL+K K  L++  +D +  L  Q+Q+    E
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440

Query: 79   LEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITIL 138
             +++   Q  AE   +  ++ ++    R + + + ++  A   A  LE        +  L
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEE--RDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498

Query: 139  QDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRK 198
                  ++++LMS+ +   K + E  EK + +L+ QV+ +  Q + L D  +  E+A   
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHE-LEKSKRALEQQVEEMKTQLEELEDELQATEDA--- 1554

Query: 199  NTEEQLEIAL-APYQHLEEDMKSLKQVLEMKNQQIHEQEKKI-LELEKLAEKNIILEEKI 256
              + +LE+ L A     E D++   +  E K +Q+  Q +++  ELE   ++  +     
Sbjct: 1555 --KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612

Query: 257  QVLQQQNEDLKARID------------------QNTVVTRQLSEENANLQEYVEKETQEK 298
            + L+   +DL+A ID                  Q     R+L +  A+ +E + +  + +
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672

Query: 299  KRLSRTNEELL 309
            K+L     E++
Sbjct: 1673 KKLKSMEAEMI 1683



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 76/297 (25%), Positives = 131/297 (44%), Gaps = 41/297 (13%)

Query: 45   AKCEKLQKEKEE---LERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQ 101
            AK E+L K +E+    E R   E++ L  Q  AE  +L+E  QLQ E E+    EE   +
Sbjct: 849  AKEEELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQE--QLQAETELCAEAEELRAR 905

Query: 102  LLSIRCQHQEQVEDLTASHD----------AALLEMENNHTVAITILQDDHD--HKVQEL 149
            L + + + +E   DL A  +          A   +M+ N       L+++     K+Q  
Sbjct: 906  LTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLE 965

Query: 150  MSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALA 209
              T E + K+LEE     ++ L+DQ   L  + + L DR   F   L +  E+   +A  
Sbjct: 966  KVTTEAKLKKLEEE----QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 210  PYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE--------KLAEKNIILEEKIQVLQQ 261
              +H E  +  L++ L  + +Q  E EK   +LE        ++AE    + E    L +
Sbjct: 1022 KNKH-EAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080

Query: 262  QNEDLK---ARIDQNTV-------VTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E+L+   AR+++            R+L  + + LQE +E E   + +  +   +L
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 75/343 (21%), Positives = 143/343 (41%), Gaps = 45/343 (13%)

Query: 16   DKTNESALVKEKEL-SIELANIRDEVAFHTAKCEKLQK----EKEELERRFED------- 63
            ++    A  +EKE  ++ LA   +E     A+ E+L K    E E+L    +D       
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522

Query: 64   -EVKRLGWQQQAE-----LQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLT 117
             E  +   +QQ E     L+ELE+ LQ     E A+L+ E   Q +  + +   Q  D  
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQA---TEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579

Query: 118  ASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEK--KELEENFEKLRLSLQDQV 175
            +      L  +     A   L+D+   +   + +  +LE   K+LE + +    +  + +
Sbjct: 1580 SEEKKKQLVRQVREMEAE--LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAI 1637

Query: 176  DTLTFQSQSLRDRARRFEE---------ALRKNTEEQLEIALAPYQHLEEDMKSLKQVLE 226
              L      ++D  R  ++         A  K  E++L+   A    L+E++ + ++   
Sbjct: 1638 KQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR 1697

Query: 227  MKNQQIHEQEKKI----------LELEKLAEKNII-LEEKIQVLQQQNEDLKARIDQNTV 275
               Q+  E   +I          LE ++  E  I  LEE+++  Q   E +  R+ +  +
Sbjct: 1698 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANL 1757

Query: 276  VTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPT 318
               Q++ +    + + +K    +++L R N+EL  KLQ  + T
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 76/334 (22%), Positives = 158/334 (47%), Gaps = 52/334 (15%)

Query: 15   LDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQA 74
            L+K+  +   + +E+  +L  + DE+        +L+   + ++ +FE +++  G  +Q+
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ--GRDEQS 1580

Query: 75   ELQELEERLQLQFEAEMARLQEEHGDQLLSI--RCQHQEQVEDLTASHDAA--------- 123
            E  E +++L  Q     A L++E   + +++  R + +  ++DL A  D+A         
Sbjct: 1581 E--EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638

Query: 124  -LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQV---DTLT 179
             L +++      +  L D    + + L    E EKK   ++ E   + LQ+++   +   
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK--LKSMEAEMIQLQEELAAAERAK 1696

Query: 180  FQSQSLRDRA------RRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIH 233
             Q+Q  RD           + AL    + +LE  +A    LEE+++  +   E+ N ++ 
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIA---QLEEELEEEQGNTELINDRLK 1753

Query: 234  EQEKKI------LELEKL-AEKNIILEEKIQVLQQQNEDLKARID--QNTVVTR------ 278
            +   +I      L LE+  A+KN   E   Q L++QN++LK ++   + TV ++      
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKN---ENARQQLERQNKELKVKLQEMEGTVKSKYKASIT 1810

Query: 279  QLSEENANLQEYVEKETQEK----KRLSRTNEEL 308
             L  + A L+E ++ ET+E+    K++ RT ++L
Sbjct: 1811 ALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 65/300 (21%), Positives = 128/300 (42%), Gaps = 33/300 (11%)

Query: 10   NCLQCLDKTNES-----ALVKEKE-----LSIELANIRDEVAFHTAKCEKLQKEKEELER 59
            +C++ LD T  S     A  KE E     +  E+  +++E+A       + Q+E++EL  
Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA- 1707

Query: 60   RFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGD-QLLSIRCQHQE-QVEDLT 117
               DE+     +    L+E + RL+ +       L+EE G+ +L++ R +    Q++ + 
Sbjct: 1708 ---DEIANSSGKGALALEE-KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763

Query: 118  ASHDAALLEMENNHTVAITILQDDHDHKV--QELMSTHELEKKELEENFEKLRLSLQDQV 175
               +      + N      + + + + KV  QE+  T + + K      E     L++Q+
Sbjct: 1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823

Query: 176  DTLTFQSQSLRDRARRFEEAL----------RKNTEEQLEIALAPYQHLEEDMKSLKQVL 225
            D  T + Q+   + RR E+ L          R+N E+  + A      L++  + L++  
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883

Query: 226  EMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENA 285
            E   +    + K   ELE   E    +  ++  L+ +      R D   VV R+++ + A
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKNK----LRRGDLPFVVPRRMARKGA 1939



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 39/137 (28%), Positives = 62/137 (45%), Gaps = 9/137 (6%)

Query: 191 RFEEALRKNTEEQLEIA---LAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAE 247
           R EE +    EE +++    LA    L E M++L+  L  +  Q+ EQ +   EL   AE
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTE-METLQSQLMAEKLQLQEQLQAETELCAEAE 900

Query: 248 K-NIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNE 306
           +    L  K Q L++   DL+AR+++     + L  E   +Q+ +    QE +      E
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI----QELEEQLEEEE 956

Query: 307 ELLWKLQTGDPTSPIKL 323
               KLQ    T+  KL
Sbjct: 957 SARQKLQLEKVTTEAKL 973



 Score = 30.0 bits (66), Expect = 3.2
 Identities = 17/75 (22%), Positives = 41/75 (54%), Gaps = 3/75 (4%)

Query: 225 LEMKNQQ---IHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLS 281
           L+++N Q   +  + K +L++ +  E+ +  EE++  ++++    + R+ +   +  QL 
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879

Query: 282 EENANLQEYVEKETQ 296
            E   LQE ++ ET+
Sbjct: 880 AEKLQLQEQLQAETE 894


>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
           sapiens]
          Length = 955

 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 77/322 (23%), Positives = 148/322 (45%), Gaps = 34/322 (10%)

Query: 25  KEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQ-QAELQELEERL 83
           K  +L  EL   +++      K E+  KEKEE   R   EV+RL  QQ  A L+E + ++
Sbjct: 552 KAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRV-TEVQRLQAQQADAALEEFKRQV 610

Query: 84  QLQFEAEMARLQEE----HGDQLLSIRCQHQE------QVEDLTASHDAALLEMENNHTV 133
           +L  E   A ++E+      D   S   + ++      Q+ED+   ++  ++E++  H  
Sbjct: 611 ELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQ 670

Query: 134 AITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQ-SQSLRDRARRF 192
             T L   H+ +   L+  HE E + LE+      +  ++Q+     + +Q + D   + 
Sbjct: 671 EKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQV 730

Query: 193 ----EEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEK--LA 246
               EE +  N++ + ++        EE  ++ ++   + N+   E EK  +EL+K   A
Sbjct: 731 HKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAA 790

Query: 247 EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQ-------LSEENA--------NLQEYV 291
           E  + LE+    L+Q  ++   ++ +++ +  +       L EEN+         LQ+  
Sbjct: 791 ETEMTLEKANSKLKQIEKEYTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVR 850

Query: 292 EKETQEKKRLSRTNEELLWKLQ 313
           +K   EKK+L R N++ +  LQ
Sbjct: 851 QKFEDEKKQLIRDNDQAIKVLQ 872



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 64/298 (21%), Positives = 140/298 (46%), Gaps = 28/298 (9%)

Query: 27  KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFE------DEVKR----LGWQQQAEL 76
           KEL   +  +  E      + +KL +EK ELER ++       EVK     L  ++   +
Sbjct: 411 KELEARVQQLTGEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLV 470

Query: 77  QELEER---LQLQFEAEMARLQEEHG----------DQLLSIRCQHQEQVEDLTASHDAA 123
            + E+    LQ +++A++  L++EH           ++L    CQ ++Q+++        
Sbjct: 471 NDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQ 530

Query: 124 LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
           L + EN   +  + L+  ++ K  +L S  +  K++ ++   K   +L+++ + LT  ++
Sbjct: 531 LRDQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTE 590

Query: 184 SLRDRARRFEEALRKNTEEQLEI-ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKIL-E 241
             R +A++ + AL +  + Q+E+ +   Y  ++E M+ ++  L        +Q K+ L +
Sbjct: 591 VQRLQAQQADAAL-EEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQ 649

Query: 242 LEKLAEK--NIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQE 297
           LE + ++    I+E K++  Q++   L+    +   + R    E  NL++ +     E
Sbjct: 650 LEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANME 707



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 63/318 (19%), Positives = 133/318 (41%), Gaps = 38/318 (11%)

Query: 24  VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
           ++EKEL ++   +  E  FH        +EK +L+++ + +V+++  ++  E++EL+   
Sbjct: 252 IREKELDMKTKMM--EAKFH--------EEKLKLQQKHDADVQKILERKNNEIEELKTLY 301

Query: 84  Q-LQFEAEMARLQEEHGDQLLSIRCQ-----HQEQVEDLTASHDAALLEMENN-----HT 132
           +  Q E E    + E   Q L   CQ      ++Q+ +L    + +   + N+     H 
Sbjct: 302 RSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHN 361

Query: 133 VAITI------LQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLR 186
               +      LQ  H   +QEL+    +   ++E  +     S    +  L  + Q L 
Sbjct: 362 AVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLT 421

Query: 187 DRARRFEEALRKNTEEQLEIALAPYQHLEE--DMKSLKQVLEMKNQQI---HEQEKKILE 241
             A       +K  +E+ E+         E  ++K+ +  L  +   +   +EQ  K+L+
Sbjct: 422 GEAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQ 481

Query: 242 LEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEEN-----ANLQEYVEKETQ 296
            +  A+ N++ +E      + +  ++  ++QN    +Q  +E+       L++   K   
Sbjct: 482 TKYDADINLLKQEHALSASKASSMIE-ELEQNVCQLKQQLQESELQRKQQLRDQENKFQM 540

Query: 297 EKKRLSRTNEELLWKLQT 314
           EK  L    E+    LQ+
Sbjct: 541 EKSHLKHIYEKKAHDLQS 558



 Score = 32.7 bits (73), Expect = 0.49
 Identities = 56/263 (21%), Positives = 113/263 (42%), Gaps = 45/263 (17%)

Query: 26  EKELSIELANIRDE--VAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
           E E  I+    RD   +A   A+  KL++E   +  + + ++  LG  ++ E Q    R 
Sbjct: 707 EHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQ----RA 762

Query: 84  QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHT----------- 132
             + E  + +L+ E     + ++  H  + E      ++ L ++E  +T           
Sbjct: 763 TREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKLAKSSQIIA 822

Query: 133 ---VAITILQDDH-------DHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQS 182
                I+ L++++       + ++Q++    E EKK+L  + ++    LQD+++    +S
Sbjct: 823 ELQTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELEN---RS 879

Query: 183 QSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMK-----SLKQVLEMKNQQIHEQEK 237
             +R   ++ +    K  E Q +I     Q  E  +K     SL+Q LE     I   + 
Sbjct: 880 NQVRCAEKKLQ---HKELESQEQITYI-RQEYETKLKGLMPASLRQELE---DTISSLKS 932

Query: 238 KILELEKLAEKNIILEEKIQVLQ 260
           ++  L+K A    IL+E++   Q
Sbjct: 933 QVNFLQKRAS---ILQEELTTYQ 952



 Score = 28.9 bits (63), Expect = 7.1
 Identities = 24/116 (20%), Positives = 55/116 (47%), Gaps = 1/116 (0%)

Query: 195 ALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAE-KNIILE 253
           +LRK++    +  L+  +  E DMK+     +   +++  Q+K   +++K+ E KN  +E
Sbjct: 236 SLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIE 295

Query: 254 EKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
           E   + + +  + +  I +     + L  +   ++E  E +  E K++   + E L
Sbjct: 296 ELKTLYRSKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESL 351


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 61/270 (22%), Positives = 136/270 (50%), Gaps = 18/270 (6%)

Query: 48  EKLQKEKE--ELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEE-HGDQLLS 104
           EK Q+E++  E E+R E E K   W+Q+ +++E EE+++ Q E +M R +E+ H  + + 
Sbjct: 397 EKRQEEEKIREQEKRQEQEAKM--WRQEEKIREQEEKIREQ-EKKMWRQEEKIHEQEKIR 453

Query: 105 IRCQHQEQVE-----DLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKE 159
              + QEQ E     +     +    + E  H       Q++   + +E M   E + +E
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513

Query: 160 LEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMK 219
            EE   +    +++Q + +  Q + +R++    +E   K  E++ ++        +E M+
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM------QEQEKMR 567

Query: 220 SLKQVLEMKNQQIHEQEKKILELE-KLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTR 278
             ++ +  + ++I EQ++KI E E K+ E+   + E+ +++Q+Q E +  + ++      
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627

Query: 279 QLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           ++ E+   ++   EK  +++ RL +  E++
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEKM 657



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 57/282 (20%), Positives = 130/282 (46%), Gaps = 28/282 (9%)

Query: 48  EKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRC 107
           E++  EKEE  RR E+ +    W+++ +++ELEE++    E E  R QEE   +   IR 
Sbjct: 355 EEMMWEKEEKMRRLEEMM----WEKEEKIRELEEKMH---EQEKIREQEEKRQEEEKIRE 407

Query: 108 QHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENF--- 164
           Q + Q ++         +  +              + K+ E     E EK++ +E     
Sbjct: 408 QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 467

Query: 165 -EKLRLS---------------LQDQVDTLTFQSQSLRDRARRFEEALRK--NTEEQLEI 206
            EK+R                 ++ Q + +  Q + + D+  +  E   K    EE++  
Sbjct: 468 EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIRE 527

Query: 207 ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
                +  EE ++  +++++ + +++ EQE+K+ E EK+  +   + E+ + +++Q E +
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587

Query: 267 KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           + + ++      ++ E+   +QE  EK  ++++++    E++
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 67/295 (22%), Positives = 137/295 (46%), Gaps = 55/295 (18%)

Query: 23  LVKEKE-LSIEL-------ANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQA 74
           L KE++ LS+EL         ++++ A    K + ++ EK E++   ++  ++L      
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL------ 251

Query: 75  ELQELEERLQLQFEAEMARLQEEH-GDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTV 133
                 ER +L    +  + + +H G +L S+  + Q QVE             EN    
Sbjct: 252 ------ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE-------------ENELWN 292

Query: 134 AITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFE 193
            +   Q++   + +E +   E + +E EE   +    +++Q + +  Q + + ++    E
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK----E 348

Query: 194 EALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILE 253
           E +R+  E   E         EE M+ L++++  K ++I E E+K+ E EK+ E+    +
Sbjct: 349 EKMRRQEEMMWE--------KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 400

Query: 254 EKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           E+ ++ +Q+      R +Q   + RQ  EE    QE  EK  +++K++ R  E++
Sbjct: 401 EEEKIREQEK-----RQEQEAKMWRQ--EEKIREQE--EKIREQEKKMWRQEEKI 446



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 60/275 (21%), Positives = 119/275 (43%), Gaps = 56/275 (20%)

Query: 39  EVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQ--LQFEAEMARLQE 96
           E   HT +    QK + ++   +     +   Q + E ++L  RL    +F  E+    E
Sbjct: 126 EAQVHTIRILTCQKTELQMALYYSQHAVK---QLEGEARDLISRLHDSWKFAGEL----E 178

Query: 97  EHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELE 156
           +    + + + +    +E+LT   DA  LE+  N T+    L++ +  K+QE +   E E
Sbjct: 179 QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKEKNA-KLQEKLQLVESE 236

Query: 157 KKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEE 216
           K E++ N ++L+                     R+ E A     ++QL+   A   HL +
Sbjct: 237 KSEIQLNVKELK---------------------RKLERAKLLLPQQQLQ---AEADHLGK 272

Query: 217 DMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVV 276
           +++S+   L+    Q+ E E      ++  EK    EEKIQ  +++              
Sbjct: 273 ELQSVSAKLQA---QVEENELWNRLNQQQEEKMWRQEEKIQEWEEK-------------- 315

Query: 277 TRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
              + E+   ++E  EK  ++++++ R  EE++W+
Sbjct: 316 ---IQEQEEKIREQEEKIREQEEKMRR-QEEMMWE 346



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 41/164 (25%), Positives = 75/164 (45%), Gaps = 23/164 (14%)

Query: 154 ELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQH 213
           E E+K   ++ E LR  L+ QV T+                  R  T ++ E+ +A Y +
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTI------------------RILTCQKTELQMALY-Y 148

Query: 214 LEEDMKSLKQVLEMKNQQIHEQEKKILELEK----LAEKNIILEEKIQVLQQQNEDLKAR 269
            +  +K L+        ++H+  K   ELE+    +A +    +  I+ L ++ + L   
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 208

Query: 270 IDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
           + +NT+   +L E+NA LQE ++    EK  +    +EL  KL+
Sbjct: 209 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2373 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2551

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2601

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2602 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2640



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2055 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2112

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2113 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2223

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2255



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1366 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1412

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1471

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1520

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1521 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1527

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1583

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1706

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1765

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1766 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1823 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1862



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1304 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1418

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1419 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2356

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2406

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2454

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2455 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2554



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2029 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2324

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1333

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1334 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1389

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1450 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1494

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2649

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2650 RRKVSAQRLQEAGILSAEELQRLA 2673



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1267

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1268 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1311

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1361

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2377 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2496 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2555

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2556 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2605

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2606 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2644



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1998

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 1999 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2058

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2059 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2116

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2117 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2174

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2175 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2227

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2259



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1370 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1416

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1417 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1475

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1524

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1525 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1531

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1532 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1587

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1647

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1708 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1710

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1769

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1770 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1827 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1866



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1308 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1422

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1423 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1476

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2360

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2410

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2458

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2459 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2503

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2504 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2558



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2033 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2152 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2211

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2269

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2328

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1337

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1338 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1393

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1394 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1453

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1454 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1498

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2476 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2593

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2594 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2653

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2654 RRKVSAQRLQEAGILSAEELQRLA 2677



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1153 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1212

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1213 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1271

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1272 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1315

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1316 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1365

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1406


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2373 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2551

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2601

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2602 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2640



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 1995 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2055 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2112

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2113 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2223

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2255



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1366 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1412

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1471

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1520

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1521 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1527

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1583

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1643

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1706

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1765

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1766 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1823 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1862



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1304 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1418

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1419 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2356

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2406

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2454

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2455 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2554



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2029 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2148 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2207

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2265

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2324

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1333

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1334 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1389

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1390 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1449

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1450 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1494

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2472 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2590 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2649

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2650 RRKVSAQRLQEAGILSAEELQRLA 2673



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1267

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1268 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1311

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1361

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1402


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2341 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2460 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2519

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2520 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2569

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2570 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2608



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1962

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 1963 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2022

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2023 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2080

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2081 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2138

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2139 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2191

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2223



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1334 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1380

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1381 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1439

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1488

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1489 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1594



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1495

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1496 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1551

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1611

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1672 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1674

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1733

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1734 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1791 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1830



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1272 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1386

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1387 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1440

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2324

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2374

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2422

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2423 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2467

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2468 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2522



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 1997 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2056 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2116 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2175

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2233

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2292

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1301

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1302 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1357

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1358 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1417

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1418 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1462

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1463 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1509



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2440 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2557

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2558 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2617

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2618 RRKVSAQRLQEAGILSAEELQRLA 2641



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1117 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1176

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1177 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1235

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1236 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1279

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1280 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1329

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1370


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2510 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2629 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2688

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2689 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2738

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2739 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2777



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2131

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 2132 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2191

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2192 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2249

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2250 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2360

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2392



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1503 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1549

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1550 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1608

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1609 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1657

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1658 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1763



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1664

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1665 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1720

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1780

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1843

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1902

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1903 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1960 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1999



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1441 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1555

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1556 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1609

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2493

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2543

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2591

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2592 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2636

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2637 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2691



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2166 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2225 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2285 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2402

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2461

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1470

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1471 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1526

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1527 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1586

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1587 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1631

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1632 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1678



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2609 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2726

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2727 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2786

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2787 RRKVSAQRLQEAGILSAEELQRLA 2810



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1286 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1345

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1346 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1404

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1405 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1448

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1449 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1498

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1539


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2351 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2470 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2529

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2530 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2579

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2580 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2618



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1972

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 1973 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2032

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2033 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2090

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2091 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2148

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2149 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2201

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2233



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1344 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1390

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1391 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1449

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1450 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1498

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1499 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1604



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1505

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1506 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1561

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1621

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1684

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1743

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1744 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1801 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1840



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1282 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1396

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1397 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1450

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2277 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2334

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2384

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2432

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2433 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2477

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2478 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2532



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2007 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2066 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2126 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2243

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2302

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1311

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1312 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1367

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1368 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1427

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1428 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1472

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1473 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1519



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2450 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2507

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2567

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2568 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2627

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2628 RRKVSAQRLQEAGILSAEELQRLA 2651



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1127 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1186

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1187 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1245

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1246 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1289

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1290 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1339

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1380


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2359 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2478 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2537

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2538 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2587

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2588 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2626



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1980

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 1981 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2040

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2041 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2098

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2099 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2156

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2157 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2209

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2241



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1352 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1398

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1399 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1457

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1458 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1506

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1507 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1513

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1514 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1569

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1629

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1690 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1692

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1751

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1752 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1809 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1848



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1290 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1404

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1405 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1458

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2285 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2342

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2392

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2440

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2441 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2485

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2486 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2540



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2015 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2074 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2134 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2193

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2251

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2310

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1319

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1320 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1375

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1376 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1435

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1436 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1480

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1481 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1527



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2458 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2515

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2575

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2576 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2635

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2636 RRKVSAQRLQEAGILSAEELQRLA 2659



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1135 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1194

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1195 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1253

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1254 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1297

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1298 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1347

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1388


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 72.0 bits (175), Expect = 7e-13
 Identities = 77/347 (22%), Positives = 157/347 (45%), Gaps = 41/347 (11%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVK------RLGW 70
            K    A+ +   L  E   ++ +      +  +LQ++KE++ ++  +E +          
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399

Query: 71   QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENN 130
            Q+Q E+    ERL+L+  AEM+R Q    +     R Q +E  E L  +  A   ++   
Sbjct: 2400 QRQLEMSAEAERLKLRV-AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458

Query: 131  HTVAITILQDDHD-HKVQELMSTHELEKKELEENFEKLRLSLQD----QVDTLTFQSQSL 185
             T+ I   Q DHD  +++E ++  E EK++L++  + L+L  ++    Q + L  ++Q+L
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518

Query: 186  RD----------RARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQ 235
            +           +  RF E  +   E+  +  +A  Q L E+ +  +Q +E + Q++   
Sbjct: 2519 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVAS 2578

Query: 236  EKKILELEKLAEKNIIL-EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             ++    +  AE+ +   +E++Q L+QQ    +            L+EEN  L+E ++  
Sbjct: 2579 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE----------ELLAEENQRLREQLQLL 2628

Query: 295  TQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPA 341
             ++ +     +EE+          S +  + T P  R +  GP++ A
Sbjct: 2629 EEQHRAALAHSEEV--------TASQVAATKTLPNGRDALDGPAAEA 2667



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 74/332 (22%), Positives = 141/332 (42%), Gaps = 53/332 (15%)

Query: 20   ESALVKEKELSIELANIR----------DEVAFHTAKCEKLQKEKEELERRFEDEVKR-- 67
            E A   + EL +EL  IR          ++     A+  +L  E+E   R  E+ V++  
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2021

Query: 68   -----LGWQQQAELQELEE---------------------RLQLQFEAEMARLQEEHGDQ 101
                    Q++A L+E+E                      +LQL  EA   RLQ E    
Sbjct: 2022 AAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH 2081

Query: 102  LLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELE 161
              +++ Q +++++       + L ++      A    ++  + +VQ      +  ++++E
Sbjct: 2082 AFAVQ-QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ-SRRQVE 2139

Query: 162  ENFEKLRLSLQDQVDTLTFQSQSLRDRARRF--EEALRKNTEEQ--LEIALAPYQHLEED 217
            E  E+L+ S ++Q      Q+Q+  ++ R+   +EA R+   EQ  L    A    +E+ 
Sbjct: 2140 EA-ERLKQSAEEQAQARA-QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2197

Query: 218  MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
             K  +Q L  K Q   E     L+LE+   +  +L+E++Q        LKA   +     
Sbjct: 2198 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ-------RLKAEATEAARQR 2250

Query: 278  RQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             Q+ EE  +++  +E+ ++ K R+   N  L+
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALI 2282



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/294 (21%), Positives = 127/294 (43%), Gaps = 39/294 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQEL 79
            E+AL K+++L+            H     + ++E +EL++R ++EV R   +++A +   
Sbjct: 1393 EAALEKQRQLA----------EAHAQAKAQAEREAKELQQRMQEEVVR---REEAAVDAQ 1439

Query: 80   EERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQ 139
            +++  +Q E +  R   E   Q  + + +  E+   L    +  ++ ++   T       
Sbjct: 1440 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATERQRGGA 1498

Query: 140  DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKN 199
            +     ++      E +K++ +E  E+LR  +QD+             R R+ E  L   
Sbjct: 1499 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE-----------SQRKRQAEVELASR 1547

Query: 200  TEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI--LELEKLAEKNIILEEKIQ 257
             + + E A        E  ++L Q LE    Q  E E+++   E+E+  +  + LE   +
Sbjct: 1548 VKAEAEAA-------REKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 258  VLQQQNEDLKARIDQNTV-VTRQLSEEN---ANLQEYVEKETQEKKRLSRTNEE 307
              + + +  +A   + T  + R L EE+   A L+E  E+  Q++    R  EE
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1653



 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 68/290 (23%), Positives = 128/290 (44%), Gaps = 30/290 (10%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            EL  +R       A+  + Q+E E L R+ +DE +R   ++QAE+ EL  R++   EAE 
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR---KRQAEV-ELASRVKA--EAEA 1554

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            AR ++     L  +R Q +E    L  +     +E      VA+   Q   + ++Q   +
Sbjct: 1555 AREKQRALQALEELRLQAEEAERRLRQAE----VERARQVQVALETAQRSAEAELQSKRA 1610

Query: 152  THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
            +   +  +LE + ++  +++    +    ++Q   +  R  EEA R+    QL+   A  
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1670

Query: 212  QHLEED----MKSLKQVLEMKNQQIHEQ--------EKKILELEKLAEKNIILEEKIQ-- 257
              L+ +     KSL Q    K ++  E+        E++ +   +LAE+ +  + ++   
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730

Query: 258  ------VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRL 301
                    +Q+   L+A  +Q     + L EE A LQ      TQ+++ L
Sbjct: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 17/282 (6%)

Query: 27   KELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQ 86
            +E  + +A +R+E      +  + ++ +EE ER  E    +     +  LQ  E   Q  
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1683

Query: 87   FEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKV 146
                 A  Q+E  ++    R + +EQ        + A  E+E    +A    Q       
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEEQA---VRQRELAEQELEKQRQLAEGTAQ------- 1733

Query: 147  QELMSTHELEKKELE-ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLE 205
            Q L +  EL +   E E  E+ R  L++++  L  ++ +   + +  E  L K    ++E
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK-VRAEME 1792

Query: 206  IALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED 265
            + LA     EE+ +S     E   Q++  +  +  EL + A +   L E+ +  +Q  E+
Sbjct: 1793 VLLASKARAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849

Query: 266  LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              AR  Q     R L+E+ A + E    +T+ +  L     E
Sbjct: 1850 DAAR--QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1889



 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 56/280 (20%), Positives = 120/280 (42%), Gaps = 26/280 (9%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQ 95
            +R+++    A  E++++  E++E       + +   +  ELQ +  + QL+  A  A+  
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330

Query: 96   EEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL 155
            +        I    QE V+  T   +   L  +    ++ T+ + + + ++ E     E 
Sbjct: 1331 KVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386

Query: 156  EK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHL 214
            E+  E+E   EK R   +          +  ++  +R +E + +  E  ++ A    + +
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD-AQQQKRSI 1445

Query: 215  EEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNED--------- 265
            +E+++ L+Q  E       E + K  + E      + +EE+I+V++ Q E          
Sbjct: 1446 QEELQQLRQSSEA------EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1499

Query: 266  -----LKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 300
                 L+AR ++     RQ  EE   L+  V+ E+Q K++
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 75/298 (25%), Positives = 119/298 (39%), Gaps = 70/298 (23%)

Query: 38   DEVAFHTAKCEKLQKEKEELER---RFEDEVKRLGWQQQAEL-QELEERLQLQFEAEMAR 93
            +++A   A  EK+ KEK +  +   R + E + L  QQQ EL QE   RLQ   E    +
Sbjct: 2326 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQ 2383

Query: 94   LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTH 153
            L EE      ++  + Q Q+E    +    L   E +   A          + +E     
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA----------RAEEDAQRF 2433

Query: 154  ELEKKELEENFEKLRLSLQDQV---DTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAP 210
              + +E+ E   +  L+ Q++V    TL  Q Q     A R  EA+ +            
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE------------ 2481

Query: 211  YQHLEEDMKSLKQVLEMKNQQIHEQEKKILEL---------------EKLAEKNIILEEK 255
               LE + + L            +QE K+L+L               E  A +   L EK
Sbjct: 2482 ---LEREKEKL------------QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2526

Query: 256  IQVLQQQN--EDLKARIDQ----NTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEE 307
              +LQ++   E  KA+++Q         +QL EE    Q+ +E   QE++RL  + EE
Sbjct: 2527 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEE 2581



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 72/333 (21%), Positives = 133/333 (39%), Gaps = 44/333 (13%)

Query: 20   ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDE---VKRLGWQQQAEL 76
            E    ++ +L+ E A  R + A   A    +Q++++EL++  + E   + +L  + +A  
Sbjct: 2056 EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114

Query: 77   QELEE----RLQLQFEAEMARLQEEHGDQL-------LSIRCQHQEQVEDLT--ASHDAA 123
            +  EE    R+Q + EA  +R Q E  ++L          R Q Q   E L   A  +AA
Sbjct: 2115 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174

Query: 124  LLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                     +      D    K ++       +K ++E+    LRL L++         +
Sbjct: 2175 RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2234

Query: 184  SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQI----------- 232
             L+       EA R+ ++ + E+     Q   E++  LK  +E +N+ +           
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSVRVQM--EELSKLKARIEAENRALILRDKDNTQRF 2292

Query: 233  --HEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL-----------KARIDQNTVVTRQ 279
               E EK     E+ A  ++  +E  ++ Q   EDL           K ++      TR 
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR- 2351

Query: 280  LSEENANLQEYVEKETQEKKRLSRTNEELLWKL 312
            L  E   LQ+  E   ++ +RL    E++  +L
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 60/287 (20%), Positives = 128/287 (44%), Gaps = 26/287 (9%)

Query: 24   VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERL 83
            +K+ EL +     + E     AK  K+Q   E + + + D          +EL  L  + 
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY-----SELTTLTSQY 1360

Query: 84   QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHD 143
             ++F +E  R  EE        R + +E++ ++ A+ +    ++   H  A    Q + +
Sbjct: 1361 -IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQAKA--QAERE 1416

Query: 144  HK-VQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS-LRDRARRFEEALRKNTE 201
             K +Q+ M    + ++E   + ++ + S+Q+++  L   S++ ++ +AR+ E A R    
Sbjct: 1417 AKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLR 1476

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
                        +EE+++ ++  LE   +Q    E ++  L   AE+    E + +  Q+
Sbjct: 1477 ------------IEEEIRVVRLQLEATERQRGGAEGELQALRARAEE---AEAQKRQAQE 1521

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            + E L+ ++   +   RQ   E A+  +   +  +EK+R  +  EEL
Sbjct: 1522 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1568



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 44/204 (21%), Positives = 89/204 (43%), Gaps = 15/204 (7%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKE------KEELERRFEDEVKRLGW 70
            K+ E   V++++L  E   ++   +F + K   LQ+E      K +LE+ F+DEV +   
Sbjct: 2499 KSEEMQTVQQEQLLQETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2556

Query: 71   ----QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
                QQ+ + Q  +ER +L    E AR ++   ++ +  + +  +Q+E      +  L E
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2616

Query: 127  MENNHTVAITILQDDHDHKV---QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
                    + +L++ H   +   +E+ ++     K L    + L     +     +F   
Sbjct: 2617 ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGL 2676

Query: 184  SLRDRARRFEEALRKNTEEQLEIA 207
              +  A+R +EA   + EE   +A
Sbjct: 2677 RRKVSAQRLQEAGILSAEELQRLA 2700



 Score = 33.5 bits (75), Expect = 0.29
 Identities = 60/283 (21%), Positives = 118/283 (41%), Gaps = 38/283 (13%)

Query: 36   IRDEVAFHTAKCEKLQKEKEELE---RRFEDEVKRLGWQQQAELQELEERL-QLQFEAEM 91
            +RDE+       E+LQ+   E +    R+ + V +L  + QA L + + R  +L+     
Sbjct: 1176 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1235

Query: 92   ARLQEEHGDQL---LSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQE 148
             R   E  D L   L    + QEQ++ +  +   A+ E        +  ++  H  KV+E
Sbjct: 1236 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER-HGEKVEE 1294

Query: 149  LMSTHELEKKELEENFEKLRLS-LQD-QVDTLTFQSQSLRDRARRFEEALRKNTEEQLEI 206
                         + F K  ++ ++D ++  +T+++Q L   A     A +   +   E 
Sbjct: 1295 C------------QRFAKQYINAIKDYELQLVTYKAQ-LEPVA---SPAKKPKVQSGSES 1338

Query: 207  ALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDL 266
             +  Y  L      L  +     + I E  +++ E E+LAE+           + +  + 
Sbjct: 1339 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ----------RAEERER 1388

Query: 267  KARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELL 309
             A ++      RQL+E +A  +   E+E +E ++  R  EE++
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ--RMQEEVV 1429


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 87/339 (25%), Positives = 156/339 (46%), Gaps = 56/339 (16%)

Query: 25  KEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRF----EDEVKRLGWQ----QQAEL 76
           KE EL  E      EV  +  K E L+KEK  +  R     E E++RL  Q     + EL
Sbjct: 583 KELELKHEA-----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637

Query: 77  QELEERLQLQFEAEMARLQEEHG----DQLLSIRCQHQEQVEDLTASHDAALLEMENNHT 132
            +L+E L+++    + +L++  G     Q+  ++ +  +++E +    D  L+  +N   
Sbjct: 638 SKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN-LITKQNQLI 696

Query: 133 VAITILQDDHDHKVQELMSTHELEKKELEENFEKLRL------SLQDQVDTLTFQSQSLR 186
           + I+ L+D     V        L+  EL++  E LR       +L+ +V  L  +++ L 
Sbjct: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 756

Query: 187 DRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLA 246
            + +  E  L++    QLE   A    L+++ K+L+ +L++      E+    L+  K  
Sbjct: 757 KQMKEKENDLQEKFA-QLE---AENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812

Query: 247 EKNIILEEKIQVLQQQNEDLKAR-IDQNTVVTRQ-----LSEEN--ANLQEYVE------ 292
            K+ + E++I++L ++NEDLK + I  N  + +Q      +E+N   N QE  E      
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872

Query: 293 ------------KETQEKKRLSRTNEELLWKLQTGDPTS 319
                       +E + K +L   NEEL   LQ  +PT+
Sbjct: 873 KVKDDLEDSKNKQELEYKSKLKALNEEL--HLQRINPTT 909



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 74/316 (23%), Positives = 146/316 (46%), Gaps = 32/316 (10%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL 76
            K     L + +   +E+ +  DEV          QK+  EL+   E E  +LG  ++ + 
Sbjct: 3180 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDK 3239

Query: 77   QELEERLQLQFEAEMAR-----LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
            +ELE+ L+   E++  R     L  E   QLL+   + Q+++E     +DA L E E   
Sbjct: 3240 EELED-LKFSLESQKQRNLQLNLLLEQQKQLLN---ESQQKIESQRMLYDAQLSE-EQGR 3294

Query: 132  TVAITILQDDHDHKVQELMSTHELEKK-----ELEENFEKLRLSLQDQVDTLTFQSQSLR 186
             + + +L +    +++E+ ST + E++     +  +   + R  L  + D L    + L 
Sbjct: 3295 NLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-DLLKELQKQLE 3353

Query: 187  DRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLA 246
            ++  R  E L +  + +L+ +L   Q +E+D +  ++ L+ + +   E +KK+ E     
Sbjct: 3354 EKHSRIVELLNETEKYKLD-SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE----- 3407

Query: 247  EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLS--EENANLQEYVEKETQEKKRL--S 302
                 L+ K++ LQ+Q E+ + ++ +  +  ++L    +    QE   +E +E +R+   
Sbjct: 3408 -----LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ 3462

Query: 303  RTNEELLWKLQTGDPT 318
              NE   W L T D T
Sbjct: 3463 NLNEPTTWSL-TSDRT 3477



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 66/288 (22%), Positives = 139/288 (48%), Gaps = 34/288 (11%)

Query: 27  KELSIELANIRDEVAFHTAKCEKLQKEKEELERR------FE-DEVKRLGWQQQAELQEL 79
           K + +EL N + +    + + ++L    EEL++R      FE D V+R+  + Q +L++L
Sbjct: 374 KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433

Query: 80  EERLQLQFEAEMARLQEE----HGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAI 135
              L   +  ++ ++++E    H  Q+  ++ +H+ ++E+   S+    +  +    + +
Sbjct: 434 RAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493

Query: 136 TILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEA 195
            I  ++ + K+Q+  S  E  K+EL    E+ + +LQ Q++ L  +    R++ +R  + 
Sbjct: 494 AI--NELNIKLQDTNSQKEKLKEELGLILEE-KCALQRQLEDLVEELSFSREQIQRARQT 550

Query: 196 LRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQE-KKILELEKLAE------- 247
           + +   +           L E  KSL  V ++K + +   E +K LEL+  AE       
Sbjct: 551 IAEQESK-----------LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599

Query: 248 KNIILEEKIQVLQQQNEDLKARIDQ-NTVVTRQLSEENANLQEYVEKE 294
             ++ +EK  VL +  E  +A +++  T +     EE + L+E +E E
Sbjct: 600 LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 33/276 (11%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            E+  + + +   T KC +L   KE+L+R  ++        +  E+++LE R++       
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQE--------RNEEIEKLEFRVR------- 2154

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAAL-LEMENNHTVAITILQDDHDHKVQELM 150
                    +Q L +     ++VED    H  A+  + E +  V +   +D  D K +E+ 
Sbjct: 2155 ------ELEQALLVSADTFQKVED--RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206

Query: 151  STHE-LE--KKELE---ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRK---NTE 201
            +  E LE  ++ELE   E  ++L + L+ Q    T + Q L    + F++ + K     +
Sbjct: 2207 NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2266

Query: 202  EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
            E   ++      L      + Q  E++  Q++EQ  K+ +  K+   N ++EEK ++++ 
Sbjct: 2267 ESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD 2326

Query: 262  QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQE 297
                ++  +     V R   EE   L E +EK  QE
Sbjct: 2327 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 72/317 (22%), Positives = 139/317 (43%), Gaps = 51/317 (16%)

Query: 45   AKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELE----ERLQLQFEAEMAR------- 93
            A+ +++Q+E+E L R+ E      G  +Q  LQE E    E+L++Q +AE  R       
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV 2023

Query: 94   ----------------LQEEHGDQLLSIRCQHQ---EQVEDLTASHDAALLEMENNHTVA 134
                            L++E   +L+ +R Q+Q   +Q+E +    D   ++ E+   V 
Sbjct: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVF 2083

Query: 135  ITILQ--DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRF 192
               +Q  +     V       E + +E+E+    L+       + L  + Q  RD   R 
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143

Query: 193  EEALR-----KNTEEQLEIALAPYQHLEEDMK----------SLKQVLEMKNQQIHEQEK 237
            EE  +     +  E+ L ++   +Q +E+             SL+  L+ +   I  +EK
Sbjct: 2144 EEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEK 2203

Query: 238  KILELEKLAEK-NIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEK--- 293
            +I  LE+  E+    LE K + +QQ +  L+ +  ++T   ++L +EN   ++ +EK   
Sbjct: 2204 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGL 2263

Query: 294  ETQEKKRLSRTNEELLW 310
              +E   +S  ++ +L+
Sbjct: 2264 AIKESDAMSTQDQHVLF 2280



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 69/280 (24%), Positives = 127/280 (45%), Gaps = 41/280 (14%)

Query: 51  QKEKEELERRFEDEVKRLGWQQQAELQELEERL--------QLQFEAEMARLQ-EEHGDQ 101
           Q E EEL R  E+     G +   +LQE E  +        QL    + AR + +E   +
Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227

Query: 102 LLSIRCQHQE---QVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKK 158
            L +  Q Q+   Q + L AS     L    + + A  +LQ     K Q L    +LE++
Sbjct: 228 FLELTEQSQKLQIQFQQLQASET---LRNSTHSSTAADLLQA----KQQILTHQQQLEEQ 280

Query: 159 E-LEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEED 217
           + L E+++K +       +  T Q   L+++ + +E    K  E   +          E+
Sbjct: 281 DHLLEDYQKKK-------EDFTMQISFLQEKIKVYEMEQDKKVENSNK----------EE 323

Query: 218 MKSLKQVLEMKNQQIHEQEKKILEL-EKLAEKNIILEEKIQVLQQQNED---LKARIDQN 273
           ++  + ++E  N +I E+EKK LEL +KL   + +L E  + + Q+N++   +K  +  +
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383

Query: 274 TVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
               RQ SEE   L   VE+  +   + S+   +++ +++
Sbjct: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRME 423



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 71/313 (22%), Positives = 142/313 (45%), Gaps = 49/313 (15%)

Query: 28  ELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQF 87
           EL+I+L +   +      +   + +EK  L+R+ ED V+ L +      +E  +R +   
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-----REQIQRARQTI 551

Query: 88  EAEMARLQEEHG-----DQLLSIRCQHQEQVEDLTASHDAAL------LEM-ENNHTVAI 135
             + ++L E H      + L +      E  ++L   H+A +      LEM E      +
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611

Query: 136 TILQDDHDHKVQ----ELMSTHELEKKELEE--------NFEKLRLSL----QDQVDTLT 179
             + +  + +++    +L+ +HE E  +L+E        N EKL+ +L    + Q+D L 
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671

Query: 180 FQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI 239
               S +    +FE+      + QL + ++  + L++ + + K   E    QI+E +K+I
Sbjct: 672 -NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS--EEMTLQINELQKEI 728

Query: 240 LELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQE---YVEKETQ 296
             L +  ++   LE+++Q LQ + E          ++ +Q+ E+  +LQE    +E E  
Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTE----------LLEKQMKEKENDLQEKFAQLEAENS 778

Query: 297 EKKRLSRTNEELL 309
             K   +T E++L
Sbjct: 779 ILKDEKKTLEDML 791



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 70/295 (23%), Positives = 128/295 (43%), Gaps = 40/295 (13%)

Query: 48   EKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMAR--LQEEHGDQLLSI 105
            ++LQK+ EE   R    V+ L   ++ +L  L+ R Q++ + ++ R  LQ E        
Sbjct: 3346 KELQKQLEEKHSRI---VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ 3402

Query: 106  RCQH--QEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEEN 163
            +  H  Q +VEDL        LE +      +    D    ++Q +M   + ++ E EE 
Sbjct: 3403 KKMHELQSKVEDLQRQ-----LEEKRQQVYKL----DLEGQRLQGIMQEFQKQELEREEK 3453

Query: 164  FEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQ-------HLEE 216
             E  R+  Q+  +  T+   S R R    ++ +   T+E     L           H  E
Sbjct: 3454 RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE 3513

Query: 217  DMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII-----LEEKIQVLQ----QQNEDLK 267
             ++   Q +  K Q + ++  + L+ E   +++ I     ++E I  LQ    QQ E+  
Sbjct: 3514 MIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEE-P 3572

Query: 268  ARIDQNTV---VTRQLSEENANLQEYVEKETQEKKRL----SRTNEELLWKLQTG 315
            + +  +T    +T +L  +NA L  ++ + T+EK  L     +  E++ W  QTG
Sbjct: 3573 SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG 3627



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 60/285 (21%), Positives = 116/285 (40%), Gaps = 35/285 (12%)

Query: 48   EKLQKEKEELERR--FEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSI 105
            E + +   +LE     + E+ R  ++Q+   QE  E L+ Q E      +E    + L++
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQK---QEATESLKCQEELRERLHEESRAREQLAV 1915

Query: 106  RCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELM-STHELEKKELEENF 164
                 E V D  A  +  L E +      I       D   QEL+ +++ L++ E E+  
Sbjct: 1916 ELSKAEGVIDGYAD-EKTLFERQIQEKTDII------DRLEQELLCASNRLQELEAEQQ- 1967

Query: 165  EKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQV 224
                  +Q++ + L+ Q ++++  A   E+ L + TE+ ++  L      E+    L++ 
Sbjct: 1968 -----QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2022

Query: 225  LEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEEN 284
            ++     + EQ  + +ELE                Q++N +L     QN  + +QL +  
Sbjct: 2023 VKALEIDVEEQVSRFIELE----------------QEKNTELMDLRQQNQALEKQLEKMR 2066

Query: 285  ANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPV 329
              L E       E+    +  ++L  +L+      PI    T  V
Sbjct: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 55/253 (21%), Positives = 114/253 (45%), Gaps = 28/253 (11%)

Query: 74   AELQELEERLQLQFEAEMARLQEEH-------GDQLLSIRCQHQEQVEDLTASHDAALLE 126
            + L++L  ++QLQ EAE+    + H       G+ LL+++    E+   L A+    L  
Sbjct: 2992 SSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3051

Query: 127  MENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKL-RLSLQDQVDTLTFQSQSL 185
            +     V    L +  + ++QE      +E +   E  +K  R SL  ++  L  Q    
Sbjct: 3052 LGTTDAVG---LLNCLEQRIQE----QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3104

Query: 186  RDRARRFEEALRKNTEEQLEIALAPYQ----HLEEDMKSLKQVLEMKNQQIHEQEKKILE 241
            +   +R +E+  K ++E LE  +   Q     ++ ++ S+K       +Q+  ++  + E
Sbjct: 3105 KITLKREQES-EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3163

Query: 242  LE-KLAEKNIILEEKIQVLQQQNEDLKA-------RIDQNTVVTRQLSEENANLQEYVEK 293
            L+ +LA+  + LE  ++   +  ++L+A       + D+  ++   L+ E    +E    
Sbjct: 3164 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3223

Query: 294  ETQEKKRLSRTNE 306
              +EK +L R+ E
Sbjct: 3224 LEKEKAKLGRSEE 3236



 Score = 36.6 bits (83), Expect = 0.034
 Identities = 49/232 (21%), Positives = 93/232 (40%), Gaps = 27/232 (11%)

Query: 81   ERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQD 140
            E + ++F+ E   L +E G+    I   + +   D+  S D  L   E   +   T +  
Sbjct: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDP-HDIPESKDCVLTISEEMFSKDKTFIVR 1562

Query: 141  DHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNT 200
               H    + S     +  L E        L+D    L  Q Q  +       +A  +  
Sbjct: 1563 QSIHDEISVSSMDASRQLMLNEE------QLEDMRQELVRQYQEHQQATELLRQAHMRQM 1616

Query: 201  EEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQ 260
            E Q            ED + L++ ++  N+Q+  Q   I     ++E+  +L E+++ L+
Sbjct: 1617 ERQ-----------REDQEQLQEEIKRLNRQL-AQRSSIDNENLVSERERVLLEELEALK 1664

Query: 261  QQN----EDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            Q +    E L   +  ++  T+  +E     Q  VE++T ++K L R  E++
Sbjct: 1665 QLSLAGREKLCCELRNSSTQTQNGNEN----QGEVEEQTFKEKELDRKPEDV 1712



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 61/276 (22%), Positives = 109/276 (39%), Gaps = 36/276 (13%)

Query: 18   TNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRF-EDEVKRLGWQQQAEL 76
            T E   +K +  S+E      E + + A  + L K+K ELE    ED +K L  + Q   
Sbjct: 2427 TQELFSLKRERESVEKIQSIPENSVNVA-IDHLSKDKPELEVVLTEDALKSL--ENQTYF 2483

Query: 77   QELEERLQ---LQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTV 133
            +  EE  +   +  E  + +L+     + L +  Q  +Q++D+    +    E E     
Sbjct: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELT-QCYKQIKDM---QEQGQFETEMLQKK 2539

Query: 134  AITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFE 193
             + + +   +     L+S  +LE  +    F +         D  T  S+  R   +   
Sbjct: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ---------DNQTISSEPERTNIQNLN 2590

Query: 194  EALRKNTEEQLEIALAPYQHLEEDMKSL-------KQVLEMKNQQIHEQEKKILELEKLA 246
            +         +         LE  +  +       K+ +E+  + + E+EKK+LEL+KL 
Sbjct: 2591 QLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL 2650

Query: 247  EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSE 282
            E N    EK     +Q E  K R  Q+  V +  +E
Sbjct: 2651 EGN----EK-----KQREKEKKRSPQDVEVLKTTTE 2677



 Score = 33.9 bits (76), Expect = 0.22
 Identities = 45/229 (19%), Positives = 94/229 (41%), Gaps = 36/229 (15%)

Query: 28   ELSIELANIRDEVAFHTAKCEKLQKEKEELERRFED-----------EVKRLGWQQQAEL 76
            +LS +L     E++F   + + L++EKE++  R  +            V+    Q  + L
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020

Query: 77   QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT 136
              +        E  ++++ +  G++   I  + +   E++T   ++   ++  +H  ++T
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEES-KIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079

Query: 137  ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 196
                    K   L +T   E  +L++    L+    D           L+  A+R   +L
Sbjct: 1080 --------KESSLRATQPSENDKLQKELNVLKSEQNDL---------RLQMEAQRICLSL 1122

Query: 197  RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKL 245
              +T       +  Y   E+D    K +  +K + I  QE+KI EL+K+
Sbjct: 1123 VYSTHVD---QVREYMENEKD----KALCSLKEELIFAQEEKIKELQKI 1164



 Score = 33.1 bits (74), Expect = 0.38
 Identities = 71/317 (22%), Positives = 130/317 (41%), Gaps = 51/317 (16%)

Query: 23   LVKEKELSIELAN-----IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQ 77
            +++EKE+ I+  N     ++ ++   T    K+ +EK EL R  E +++ L   Q+   +
Sbjct: 2286 IIQEKEVEIDQLNEQVTKLQQQLKITTDN--KVIEEKNELIRDLETQIECLMSDQECVKR 2343

Query: 78   ELEERLQLQFEAEMARLQEEHGD--QLLSIRCQH-QEQVEDLTASHDAAL---------L 125
              EE ++ Q    + +LQ+E  +  Q  S+      E+ + L    D  +         +
Sbjct: 2344 NREEEIE-QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV 2402

Query: 126  EMENNHTVAITILQDDHDHKVQELMSTHEL-EKKELEENFEKLRL----SLQDQVDTLTF 180
            E  N     +  +  + + K+ +L  T EL   K   E+ EK++     S+   +D L+ 
Sbjct: 2403 ETANEEMTFMKNVLKETNFKMNQL--TQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460

Query: 181  QSQSLR-----DRARRFE-EALRKNTEE--------------QLEIALAPYQ-HLEEDMK 219
                L      D  +  E +   K+ EE              QLE  ++     L +  K
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520

Query: 220  SLKQVLEMKNQQIHEQEKKILELEKLAEKNI--ILEEKIQVLQQQNEDLKARIDQNTVVT 277
             +K + E    +    +KKI+ L+K+ E+ +   L  +IQ L+   E  K   D  T+ +
Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEYAKFCQDNQTISS 2579

Query: 278  RQLSEENANLQEYVEKE 294
                    NL +  E E
Sbjct: 2580 EPERTNIQNLNQLREDE 2596



 Score = 32.7 bits (73), Expect = 0.49
 Identities = 67/339 (19%), Positives = 135/339 (39%), Gaps = 55/339 (16%)

Query: 16   DKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAE 75
            DK N    + E E   EL + R EV       +  Q+    L  +  +E  +L       
Sbjct: 1226 DKENSGDYISENE-DPELQDYRYEV-------QDFQENMHTLLNKVTEEYNKL------- 1270

Query: 76   LQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE-MENNHTVA 134
               L+ RL   +  +   ++ E G++ L      +E+ E L+       LE ++ NH   
Sbjct: 1271 -LVLQTRLSKIWGQQTDGMKLEFGEENLP-----KEETEFLSIHSQMTNLEDIDVNHKSK 1324

Query: 135  ITILQDDHDHKVQE-------LMSTHELEKKELEENFEKLRLSLQDQVDTLTFQ------ 181
            ++ LQD    K++E       L+S+ + + KE E+N+E     LQ ++  ++        
Sbjct: 1325 LSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSL 1384

Query: 182  -------SQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHE 234
                   ++S   R       ++KN +  +E   +    ++E+   +K + +   +Q+ E
Sbjct: 1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIE--FSGEFGVKEETNIVKLLEKQYQEQLEE 1442

Query: 235  QEKKILELEKLA-----EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQE 289
            +  K++    +A     E + I   K      +      + +Q+     +LS++    Q 
Sbjct: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQT 1502

Query: 290  YVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSP 328
            +   + + K+     ++EL      G+    I LS + P
Sbjct: 1503 FETVDVKFKEEFKPLSKEL------GEHGKEILLSNSDP 1535



 Score = 29.6 bits (65), Expect = 4.2
 Identities = 36/175 (20%), Positives = 68/175 (38%), Gaps = 18/175 (10%)

Query: 152 THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
           T+ L ++E   +        QD    L      L  +    EE  R+  E ++       
Sbjct: 131 TNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL 190

Query: 212 QHLEEDMKSLK-------QVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQN- 263
           Q L+E   ++K       Q+     Q   E+++ + E  +L E++  L+ + Q LQ    
Sbjct: 191 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250

Query: 264 ----------EDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
                      DL     Q     +QL E++  L++Y +K+     ++S   E++
Sbjct: 251 LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKI 305


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 87/339 (25%), Positives = 156/339 (46%), Gaps = 56/339 (16%)

Query: 25  KEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRF----EDEVKRLGWQ----QQAEL 76
           KE EL  E      EV  +  K E L+KEK  +  R     E E++RL  Q     + EL
Sbjct: 583 KELELKHEA-----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637

Query: 77  QELEERLQLQFEAEMARLQEEHG----DQLLSIRCQHQEQVEDLTASHDAALLEMENNHT 132
            +L+E L+++    + +L++  G     Q+  ++ +  +++E +    D  L+  +N   
Sbjct: 638 SKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDN-LITKQNQLI 696

Query: 133 VAITILQDDHDHKVQELMSTHELEKKELEENFEKLRL------SLQDQVDTLTFQSQSLR 186
           + I+ L+D     V        L+  EL++  E LR       +L+ +V  L  +++ L 
Sbjct: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 756

Query: 187 DRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLA 246
            + +  E  L++    QLE   A    L+++ K+L+ +L++      E+    L+  K  
Sbjct: 757 KQMKEKENDLQEKFA-QLE---AENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812

Query: 247 EKNIILEEKIQVLQQQNEDLKAR-IDQNTVVTRQ-----LSEEN--ANLQEYVE------ 292
            K+ + E++I++L ++NEDLK + I  N  + +Q      +E+N   N QE  E      
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872

Query: 293 ------------KETQEKKRLSRTNEELLWKLQTGDPTS 319
                       +E + K +L   NEEL   LQ  +PT+
Sbjct: 873 KVKDDLEDSKNKQELEYKSKLKALNEEL--HLQRINPTT 909



 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 74/316 (23%), Positives = 146/316 (46%), Gaps = 32/316 (10%)

Query: 17   KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL 76
            K     L + +   +E+ +  DEV          QK+  EL+   E E  +LG  ++ + 
Sbjct: 3172 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDK 3231

Query: 77   QELEERLQLQFEAEMAR-----LQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
            +ELE+ L+   E++  R     L  E   QLL+   + Q+++E     +DA L E E   
Sbjct: 3232 EELED-LKFSLESQKQRNLQLNLLLEQQKQLLN---ESQQKIESQRMLYDAQLSE-EQGR 3286

Query: 132  TVAITILQDDHDHKVQELMSTHELEKK-----ELEENFEKLRLSLQDQVDTLTFQSQSLR 186
             + + +L +    +++E+ ST + E++     +  +   + R  L  + D L    + L 
Sbjct: 3287 NLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE-DLLKELQKQLE 3345

Query: 187  DRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLA 246
            ++  R  E L +  + +L+ +L   Q +E+D +  ++ L+ + +   E +KK+ E     
Sbjct: 3346 EKHSRIVELLNETEKYKLD-SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE----- 3399

Query: 247  EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLS--EENANLQEYVEKETQEKKRL--S 302
                 L+ K++ LQ+Q E+ + ++ +  +  ++L    +    QE   +E +E +R+   
Sbjct: 3400 -----LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ 3454

Query: 303  RTNEELLWKLQTGDPT 318
              NE   W L T D T
Sbjct: 3455 NLNEPTTWSL-TSDRT 3469



 Score = 58.5 bits (140), Expect = 8e-09
 Identities = 68/315 (21%), Positives = 136/315 (43%), Gaps = 55/315 (17%)

Query: 45   AKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELE----ERLQLQFEAEMAR------- 93
            A+ +++Q+E+E L R+ E      G  +Q  LQE E    E+L++Q +AE  R       
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV 2023

Query: 94   ----------------LQEEHGDQLLSIRCQHQ---EQVEDLTASHDAALLEMENNHTVA 134
                            L++E   +L+ +R Q+Q   +Q+E +    D   ++ E+   V 
Sbjct: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVF 2083

Query: 135  ITILQ---------------DDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLT 179
               +Q                +H  +  E ++ H  EK +        +  LQ  +    
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143

Query: 180  FQSQSLRDRARRFEEALRKNTEEQL-EIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKK 238
             + + L  R R  E+AL     +    +   P   LE  +++ +  ++ K ++I   E+ 
Sbjct: 2144 EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE- 2202

Query: 239  ILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEK---ET 295
              +LE+  E+   LE K + +QQ +  L+ +  ++T   ++L +EN   ++ +EK     
Sbjct: 2203 --QLEQFREE---LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2257

Query: 296  QEKKRLSRTNEELLW 310
            +E   +S  ++ +L+
Sbjct: 2258 KESDAMSTQDQHVLF 2272



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 66/288 (22%), Positives = 139/288 (48%), Gaps = 34/288 (11%)

Query: 27  KELSIELANIRDEVAFHTAKCEKLQKEKEELERR------FE-DEVKRLGWQQQAELQEL 79
           K + +EL N + +    + + ++L    EEL++R      FE D V+R+  + Q +L++L
Sbjct: 374 KNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433

Query: 80  EERLQLQFEAEMARLQEE----HGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAI 135
              L   +  ++ ++++E    H  Q+  ++ +H+ ++E+   S+    +  +    + +
Sbjct: 434 RAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493

Query: 136 TILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEA 195
            I  ++ + K+Q+  S  E  K+EL    E+ + +LQ Q++ L  +    R++ +R  + 
Sbjct: 494 AI--NELNIKLQDTNSQKEKLKEELGLILEE-KCALQRQLEDLVEELSFSREQIQRARQT 550

Query: 196 LRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQE-KKILELEKLAE------- 247
           + +   +           L E  KSL  V ++K + +   E +K LEL+  AE       
Sbjct: 551 IAEQESK-----------LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599

Query: 248 KNIILEEKIQVLQQQNEDLKARIDQ-NTVVTRQLSEENANLQEYVEKE 294
             ++ +EK  VL +  E  +A +++  T +     EE + L+E +E E
Sbjct: 600 LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 65/275 (23%), Positives = 121/275 (44%), Gaps = 39/275 (14%)

Query: 32   ELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEM 91
            E+  + + +   T KC +L   KE+L+R  ++        +  E+++LE R++   E E 
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQE--------RNEEIEKLEFRVR---ELEQ 2158

Query: 92   ARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMS 151
            A L E+          +H   VE           + E +  V +   +D  D K +E+ +
Sbjct: 2159 ALLVEDR---------KHFGAVE----------AKPELSLEVQLQAERDAIDRKEKEITN 2199

Query: 152  THE-LE--KKELE---ENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRK---NTEE 202
              E LE  ++ELE   E  ++L + L+ Q    T + Q L    + F++ + K     +E
Sbjct: 2200 LEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE 2259

Query: 203  QLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQ 262
               ++      L      + Q  E++  Q++EQ  K+ +  K+   N ++EEK ++++  
Sbjct: 2260 SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL 2319

Query: 263  NEDLKARIDQNTVVTRQLSEENANLQEYVEKETQE 297
               ++  +     V R   EE   L E +EK  QE
Sbjct: 2320 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2354



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 69/280 (24%), Positives = 127/280 (45%), Gaps = 41/280 (14%)

Query: 51  QKEKEELERRFEDEVKRLGWQQQAELQELEERL--------QLQFEAEMARLQ-EEHGDQ 101
           Q E EEL R  E+     G +   +LQE E  +        QL    + AR + +E   +
Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227

Query: 102 LLSIRCQHQE---QVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKK 158
            L +  Q Q+   Q + L AS     L    + + A  +LQ     K Q L    +LE++
Sbjct: 228 FLELTEQSQKLQIQFQQLQASET---LRNSTHSSTAADLLQA----KQQILTHQQQLEEQ 280

Query: 159 E-LEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEED 217
           + L E+++K +       +  T Q   L+++ + +E    K  E   +          E+
Sbjct: 281 DHLLEDYQKKK-------EDFTMQISFLQEKIKVYEMEQDKKVENSNK----------EE 323

Query: 218 MKSLKQVLEMKNQQIHEQEKKILEL-EKLAEKNIILEEKIQVLQQQNED---LKARIDQN 273
           ++  + ++E  N +I E+EKK LEL +KL   + +L E  + + Q+N++   +K  +  +
Sbjct: 324 IQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383

Query: 274 TVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
               RQ SEE   L   VE+  +   + S+   +++ +++
Sbjct: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRME 423



 Score = 52.0 bits (123), Expect = 8e-07
 Identities = 71/313 (22%), Positives = 142/313 (45%), Gaps = 49/313 (15%)

Query: 28  ELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQF 87
           EL+I+L +   +      +   + +EK  L+R+ ED V+ L +      +E  +R +   
Sbjct: 497 ELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS-----REQIQRARQTI 551

Query: 88  EAEMARLQEEHG-----DQLLSIRCQHQEQVEDLTASHDAAL------LEM-ENNHTVAI 135
             + ++L E H      + L +      E  ++L   H+A +      LEM E      +
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611

Query: 136 TILQDDHDHKVQ----ELMSTHELEKKELEE--------NFEKLRLSL----QDQVDTLT 179
             + +  + +++    +L+ +HE E  +L+E        N EKL+ +L    + Q+D L 
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671

Query: 180 FQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI 239
               S +    +FE+      + QL + ++  + L++ + + K   E    QI+E +K+I
Sbjct: 672 -NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKS--EEMTLQINELQKEI 728

Query: 240 LELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQE---YVEKETQ 296
             L +  ++   LE+++Q LQ + E          ++ +Q+ E+  +LQE    +E E  
Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTE----------LLEKQMKEKENDLQEKFAQLEAENS 778

Query: 297 EKKRLSRTNEELL 309
             K   +T E++L
Sbjct: 779 ILKDEKKTLEDML 791



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 70/295 (23%), Positives = 128/295 (43%), Gaps = 40/295 (13%)

Query: 48   EKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMAR--LQEEHGDQLLSI 105
            ++LQK+ EE   R    V+ L   ++ +L  L+ R Q++ + ++ R  LQ E        
Sbjct: 3338 KELQKQLEEKHSRI---VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQ 3394

Query: 106  RCQH--QEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEEN 163
            +  H  Q +VEDL        LE +      +    D    ++Q +M   + ++ E EE 
Sbjct: 3395 KKMHELQSKVEDLQRQ-----LEEKRQQVYKL----DLEGQRLQGIMQEFQKQELEREEK 3445

Query: 164  FEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQ-------HLEE 216
             E  R+  Q+  +  T+   S R R    ++ +   T+E     L           H  E
Sbjct: 3446 RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE 3505

Query: 217  DMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII-----LEEKIQVLQ----QQNEDLK 267
             ++   Q +  K Q + ++  + L+ E   +++ I     ++E I  LQ    QQ E+  
Sbjct: 3506 MIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEE-P 3564

Query: 268  ARIDQNTV---VTRQLSEENANLQEYVEKETQEKKRL----SRTNEELLWKLQTG 315
            + +  +T    +T +L  +NA L  ++ + T+EK  L     +  E++ W  QTG
Sbjct: 3565 SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG 3619



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 60/285 (21%), Positives = 116/285 (40%), Gaps = 35/285 (12%)

Query: 48   EKLQKEKEELERR--FEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSI 105
            E + +   +LE     + E+ R  ++Q+   QE  E L+ Q E      +E    + L++
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQK---QEATESLKCQEELRERLHEESRAREQLAV 1915

Query: 106  RCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELM-STHELEKKELEENF 164
                 E V D  A  +  L E +      I       D   QEL+ +++ L++ E E+  
Sbjct: 1916 ELSKAEGVIDGYAD-EKTLFERQIQEKTDII------DRLEQELLCASNRLQELEAEQQ- 1967

Query: 165  EKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQV 224
                  +Q++ + L+ Q ++++  A   E+ L + TE+ ++  L      E+    L++ 
Sbjct: 1968 -----QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2022

Query: 225  LEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEEN 284
            ++     + EQ  + +ELE                Q++N +L     QN  + +QL +  
Sbjct: 2023 VKALEIDVEEQVSRFIELE----------------QEKNTELMDLRQQNQALEKQLEKMR 2066

Query: 285  ANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPV 329
              L E       E+    +  ++L  +L+      PI    T  V
Sbjct: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111



 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 55/253 (21%), Positives = 114/253 (45%), Gaps = 28/253 (11%)

Query: 74   AELQELEERLQLQFEAEMARLQEEH-------GDQLLSIRCQHQEQVEDLTASHDAALLE 126
            + L++L  ++QLQ EAE+    + H       G+ LL+++    E+   L A+    L  
Sbjct: 2984 SSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3043

Query: 127  MENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKL-RLSLQDQVDTLTFQSQSL 185
            +     V    L +  + ++QE      +E +   E  +K  R SL  ++  L  Q    
Sbjct: 3044 LGTTDAVG---LLNCLEQRIQE----QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096

Query: 186  RDRARRFEEALRKNTEEQLEIALAPYQ----HLEEDMKSLKQVLEMKNQQIHEQEKKILE 241
            +   +R +E+  K ++E LE  +   Q     ++ ++ S+K       +Q+  ++  + E
Sbjct: 3097 KITLKREQES-EKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAE 3155

Query: 242  LE-KLAEKNIILEEKIQVLQQQNEDLKA-------RIDQNTVVTRQLSEENANLQEYVEK 293
            L+ +LA+  + LE  ++   +  ++L+A       + D+  ++   L+ E    +E    
Sbjct: 3156 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3215

Query: 294  ETQEKKRLSRTNE 306
              +EK +L R+ E
Sbjct: 3216 LEKEKAKLGRSEE 3228



 Score = 36.6 bits (83), Expect = 0.034
 Identities = 49/232 (21%), Positives = 93/232 (40%), Gaps = 27/232 (11%)

Query: 81   ERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQD 140
            E + ++F+ E   L +E G+    I   + +   D+  S D  L   E   +   T +  
Sbjct: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDP-HDIPESKDCVLTISEEMFSKDKTFIVR 1562

Query: 141  DHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNT 200
               H    + S     +  L E        L+D    L  Q Q  +       +A  +  
Sbjct: 1563 QSIHDEISVSSMDASRQLMLNEE------QLEDMRQELVRQYQEHQQATELLRQAHMRQM 1616

Query: 201  EEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQ 260
            E Q            ED + L++ ++  N+Q+  Q   I     ++E+  +L E+++ L+
Sbjct: 1617 ERQ-----------REDQEQLQEEIKRLNRQL-AQRSSIDNENLVSERERVLLEELEALK 1664

Query: 261  QQN----EDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            Q +    E L   +  ++  T+  +E     Q  VE++T ++K L R  E++
Sbjct: 1665 QLSLAGREKLCCELRNSSTQTQNGNEN----QGEVEEQTFKEKELDRKPEDV 1712



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 61/276 (22%), Positives = 109/276 (39%), Gaps = 36/276 (13%)

Query: 18   TNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRF-EDEVKRLGWQQQAEL 76
            T E   +K +  S+E      E + + A  + L K+K ELE    ED +K L  + Q   
Sbjct: 2419 TQELFSLKRERESVEKIQSIPENSVNVA-IDHLSKDKPELEVVLTEDALKSL--ENQTYF 2475

Query: 77   QELEERLQ---LQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTV 133
            +  EE  +   +  E  + +L+     + L +  Q  +Q++D+    +    E E     
Sbjct: 2476 KSFEENGKGSIINLETRLLQLESTVSAKDLELT-QCYKQIKDM---QEQGQFETEMLQKK 2531

Query: 134  AITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFE 193
             + + +   +     L+S  +LE  +    F +         D  T  S+  R   +   
Sbjct: 2532 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ---------DNQTISSEPERTNIQNLN 2582

Query: 194  EALRKNTEEQLEIALAPYQHLEEDMKSL-------KQVLEMKNQQIHEQEKKILELEKLA 246
            +         +         LE  +  +       K+ +E+  + + E+EKK+LEL+KL 
Sbjct: 2583 QLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL 2642

Query: 247  EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSE 282
            E N    EK     +Q E  K R  Q+  V +  +E
Sbjct: 2643 EGN----EK-----KQREKEKKRSPQDVEVLKTTTE 2669



 Score = 33.9 bits (76), Expect = 0.22
 Identities = 45/229 (19%), Positives = 94/229 (41%), Gaps = 36/229 (15%)

Query: 28   ELSIELANIRDEVAFHTAKCEKLQKEKEELERRFED-----------EVKRLGWQQQAEL 76
            +LS +L     E++F   + + L++EKE++  R  +            V+    Q  + L
Sbjct: 961  DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020

Query: 77   QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT 136
              +        E  ++++ +  G++   I  + +   E++T   ++   ++  +H  ++T
Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEES-KIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079

Query: 137  ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 196
                    K   L +T   E  +L++    L+    D           L+  A+R   +L
Sbjct: 1080 --------KESSLRATQPSENDKLQKELNVLKSEQNDL---------RLQMEAQRICLSL 1122

Query: 197  RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKL 245
              +T       +  Y   E+D    K +  +K + I  QE+KI EL+K+
Sbjct: 1123 VYSTHVD---QVREYMENEKD----KALCSLKEELIFAQEEKIKELQKI 1164



 Score = 33.1 bits (74), Expect = 0.38
 Identities = 71/317 (22%), Positives = 130/317 (41%), Gaps = 51/317 (16%)

Query: 23   LVKEKELSIELAN-----IRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQ 77
            +++EKE+ I+  N     ++ ++   T    K+ +EK EL R  E +++ L   Q+   +
Sbjct: 2278 IIQEKEVEIDQLNEQVTKLQQQLKITTDN--KVIEEKNELIRDLETQIECLMSDQECVKR 2335

Query: 78   ELEERLQLQFEAEMARLQEEHGD--QLLSIRCQH-QEQVEDLTASHDAAL---------L 125
              EE ++ Q    + +LQ+E  +  Q  S+      E+ + L    D  +         +
Sbjct: 2336 NREEEIE-QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV 2394

Query: 126  EMENNHTVAITILQDDHDHKVQELMSTHEL-EKKELEENFEKLRL----SLQDQVDTLTF 180
            E  N     +  +  + + K+ +L  T EL   K   E+ EK++     S+   +D L+ 
Sbjct: 2395 ETANEEMTFMKNVLKETNFKMNQL--TQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2452

Query: 181  QSQSLR-----DRARRFE-EALRKNTEE--------------QLEIALAPYQ-HLEEDMK 219
                L      D  +  E +   K+ EE              QLE  ++     L +  K
Sbjct: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2512

Query: 220  SLKQVLEMKNQQIHEQEKKILELEKLAEKNI--ILEEKIQVLQQQNEDLKARIDQNTVVT 277
             +K + E    +    +KKI+ L+K+ E+ +   L  +IQ L+   E  K   D  T+ +
Sbjct: 2513 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ-LEAVQEYAKFCQDNQTISS 2571

Query: 278  RQLSEENANLQEYVEKE 294
                    NL +  E E
Sbjct: 2572 EPERTNIQNLNQLREDE 2588



 Score = 32.7 bits (73), Expect = 0.49
 Identities = 67/339 (19%), Positives = 135/339 (39%), Gaps = 55/339 (16%)

Query: 16   DKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAE 75
            DK N    + E E   EL + R EV       +  Q+    L  +  +E  +L       
Sbjct: 1226 DKENSGDYISENE-DPELQDYRYEV-------QDFQENMHTLLNKVTEEYNKL------- 1270

Query: 76   LQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE-MENNHTVA 134
               L+ RL   +  +   ++ E G++ L      +E+ E L+       LE ++ NH   
Sbjct: 1271 -LVLQTRLSKIWGQQTDGMKLEFGEENLP-----KEETEFLSIHSQMTNLEDIDVNHKSK 1324

Query: 135  ITILQDDHDHKVQE-------LMSTHELEKKELEENFEKLRLSLQDQVDTLTFQ------ 181
            ++ LQD    K++E       L+S+ + + KE E+N+E     LQ ++  ++        
Sbjct: 1325 LSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSL 1384

Query: 182  -------SQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHE 234
                   ++S   R       ++KN +  +E   +    ++E+   +K + +   +Q+ E
Sbjct: 1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIE--FSGEFGVKEETNIVKLLEKQYQEQLEE 1442

Query: 235  QEKKILELEKLA-----EKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQE 289
            +  K++    +A     E + I   K      +      + +Q+     +LS++    Q 
Sbjct: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQT 1502

Query: 290  YVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSP 328
            +   + + K+     ++EL      G+    I LS + P
Sbjct: 1503 FETVDVKFKEEFKPLSKEL------GEHGKEILLSNSDP 1535



 Score = 29.6 bits (65), Expect = 4.2
 Identities = 36/175 (20%), Positives = 68/175 (38%), Gaps = 18/175 (10%)

Query: 152 THELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
           T+ L ++E   +        QD    L      L  +    EE  R+  E ++       
Sbjct: 131 TNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL 190

Query: 212 QHLEEDMKSLK-------QVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQN- 263
           Q L+E   ++K       Q+     Q   E+++ + E  +L E++  L+ + Q LQ    
Sbjct: 191 QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASET 250

Query: 264 ----------EDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
                      DL     Q     +QL E++  L++Y +K+     ++S   E++
Sbjct: 251 LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKI 305


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 76/305 (24%), Positives = 145/305 (47%), Gaps = 45/305 (14%)

Query: 16  DKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAE 75
           ++ +E+AL K  E ++     +D+     +K EK+Q+ +E+L +  E+E+ RL  Q++  
Sbjct: 585 EQLSEAAL-KAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQS 643

Query: 76  LQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQV----EDLTASHDAALLEMENNH 131
           L  L ERLQ   E E AR++EE   +L  +R Q Q       + + A  +A+L ++    
Sbjct: 644 LSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLR--- 700

Query: 132 TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
                          +EL S  + E+  LE+   ++   L+++++      Q+  + A+ 
Sbjct: 701 ---------------EELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK- 744

Query: 192 FEEALRKNTEEQLE------IALAPYQHLEEDMKSLKQVLEMKNQQ-IHEQEKKILELEK 244
            E+AL++   EQLE      +A    +H  E ++ L   LE K+++ +   +KKI E ++
Sbjct: 745 -EKALQQ-LREQLEGERKEAVATLEKEHSAE-LERLCSSLEAKHREVVSSLQKKIQEAQQ 801

Query: 245 LAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANL--QEYVEKETQEKKRLS 302
             E           LQ+    ++ R+ Q +        E ++L  ++  E E + ++RL 
Sbjct: 802 KEEAQ---------LQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD 852

Query: 303 RTNEE 307
           +  EE
Sbjct: 853 KMKEE 857



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 68/277 (24%), Positives = 126/277 (45%), Gaps = 53/277 (19%)

Query: 26   EKELSIELANIRDEV-AFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQ 84
            E ELS  L   R EV   H  + +K+++E +++  +          ++Q E +E ++R +
Sbjct: 829  EHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKA---------REQYEAEERKQRAE 879

Query: 85   L--QFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDH 142
            L      E+ RLQ  H  +L ++R +  +++EDL   H                    + 
Sbjct: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRH-------------------REQ 920

Query: 143  DHKVQELMSTHELEKKELEENFEKLRLSLQD-QVDTLTFQSQSLRDRAR----RFEEALR 197
            + K+Q+L    E   K++     K RL+L + Q +T   + Q L D  R    + EEA  
Sbjct: 921  ERKLQDLELDLETRAKDV-----KARLALLEVQEETARREKQQLLDVQRQVALKSEEATA 975

Query: 198  KNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQ 257
              T +QLE A   + HL +  + L+++L+       E + + L+LE   +   +L+ + Q
Sbjct: 976  --THQQLEEAQKEHTHLLQSNQQLREILD-------ELQARKLKLESQVD---LLQAQSQ 1023

Query: 258  VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKE 294
             LQ+    L+A   +   + R+++ E  N   + E +
Sbjct: 1024 QLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPD 1060



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 38/176 (21%), Positives = 87/176 (49%), Gaps = 21/176 (11%)

Query: 157 KKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEE 216
           ++E E+  EK+ +S    V      ++ +    +  E AL+   E   ++     +HL E
Sbjct: 553 QEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLE 612

Query: 217 DMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNI----------ILEEKIQVLQQQNED- 265
             +   Q  +++ +   E+E++IL L +  E+++          I EE+ ++ +++++  
Sbjct: 613 SKQEKMQ--QLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRL 670

Query: 266 --LKARIDQNTVVTRQ--LSEENANLQEYVEK-ETQEKKR---LSRTNEELLWKLQ 313
             L+A++  +T        +E+ A+LQ+  E+ E+Q+K     L + N ++L +L+
Sbjct: 671 SWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLK 726


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 76/300 (25%), Positives = 140/300 (46%), Gaps = 49/300 (16%)

Query: 39  EVAFHTAK---CEKLQKE-----KEELERRFEDEVKRLGWQQQAELQELEERLQ--LQFE 88
           E   HT +   C+K + E      ++  R+FED    LG     E ++L  RL     F 
Sbjct: 88  EAQDHTIRILTCQKTELETALYYSQDAARKFEDG--NLG-----ESKDLAGRLHHSWHFA 140

Query: 89  AEMARLQEEHGDQLLSIRCQHQEQ---VEDLTASHDAALLEMENNHTVAITILQDDHDHK 145
            E+ R        L ++   H++    +E+LT   DA  LE+  N     TI  ++   K
Sbjct: 141 GELQRA-------LSAVSTWHKKADRYIEELTKERDALSLELYRN-----TITNEELKKK 188

Query: 146 ---VQELMSTHELEKKELEENFEKLRLSLQ------DQVDTLTFQSQSLR--DRARRFEE 194
              +QE +   E EK E++ N ++L+  L+       QV T T Q +  R  +  R  E+
Sbjct: 189 NAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEK 248

Query: 195 ALRKNTE------EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEK 248
            +RK  E      E+L       +  EE M+  ++ L  + +++ EQEK++ E +KL E+
Sbjct: 249 KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQ 308

Query: 249 NIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
              ++E+ + + +Q E ++ + ++      +L E+   ++E  +K   +++R+   +E L
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 368



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 66/317 (20%), Positives = 151/317 (47%), Gaps = 36/317 (11%)

Query: 16  DKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEEL---------ERRFEDEVK 66
           +K  E   ++E+E       +R+E      + EK+QK++E +         ++R  ++ +
Sbjct: 386 EKMQEEERIRERE-----KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440

Query: 67  RLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLE 126
           +L W+Q+ ++QE EE++  Q E ++   +E  G +    R +   + ED     +  + +
Sbjct: 441 KL-WEQE-KMQEQEEKIWEQ-EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497

Query: 127 MENNHTVAITIL--QDDHDHKVQELMSTHELEKKELEENFEKLR--LSLQDQVDTLTFQS 182
            E         +  QD+   + +E M     E+K++ +  EK+R     Q+Q      Q 
Sbjct: 498 QEQKMWDQEERMWEQDERLREKEERMR----EQKKMWQQEEKMREEKKTQEQEKKTWDQE 553

Query: 183 QSLRDRAR--------RFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHE 234
           + +R+  R        R EE + +  EE+++      +  EE M   ++ ++ + +++ E
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613

Query: 235 QEKKILELE---KLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYV 291
           QE+K+ E E   K+ E+  ++ E+ + +Q+Q E +  + ++      ++ E+   +Q   
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673

Query: 292 EKETQEKKRLSRTNEEL 308
           EK  ++++++    E++
Sbjct: 674 EKMREQEEKMQGQEEKM 690



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 65/318 (20%), Positives = 149/318 (46%), Gaps = 30/318 (9%)

Query: 16  DKTNESALVKEKELSIELAN-IRDEVAFHTAKCEKLQKEKE--ELERRFEDEVKRLGWQQ 72
           +K+     VKE +  +E A  +  +V  +T + E  ++E+E  E E++   + +++ W+Q
Sbjct: 202 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM-WRQ 260

Query: 73  QAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQE--------QVEDLTASHDAAL 124
           +  L+E E +++ Q E +M R ++   +Q   +R Q +E        + E+     +  +
Sbjct: 261 EERLREQEGKMREQ-EEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKM 319

Query: 125 LEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS 184
            E E          Q++   + +E +   E + +E E+        + +Q + L  + + 
Sbjct: 320 WEQEEKMRE-----QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 374

Query: 185 LRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEK 244
           +R++ + +E+  +   EE++       +  EE M+  ++ ++ + + + EQE+K  + ++
Sbjct: 375 MREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 434

Query: 245 LAEKNIIL---------EEKIQVLQQQNEDLKARIDQNTVVTRQ--LSEENANLQEYVEK 293
           L E+   L         EEKI   +++  D +    Q   + RQ  + E+   + E  EK
Sbjct: 435 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 494

Query: 294 ETQEKKRLSRTNEELLWK 311
              +++++    EE +W+
Sbjct: 495 MRDQEQKM-WDQEERMWE 511



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 58/268 (21%), Positives = 121/268 (45%), Gaps = 19/268 (7%)

Query: 51  QKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEA--EMARLQEEHGDQLLSIRCQ 108
           +K+  E E++  D+ +R+ W+Q   L+E EER++ Q +   +  ++QEE   + +  R +
Sbjct: 344 EKQMREQEQKMRDQEERM-WEQDERLREKEERMREQEKMWEQEEKMQEE---ERIREREK 399

Query: 109 HQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL--EKKELEENFEK 166
              + E+     +  + + E N        Q++ + + Q L    E   E+++++E  EK
Sbjct: 400 KMREEEETMREQEEKMQKQEENMWE-----QEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454

Query: 167 L---RLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQ 223
           +      ++DQ +    + +  R    R +E      EE++          EE M    +
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514

Query: 224 VLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEE 283
            L  K +++ EQ+K   + EK+ E+    E++ +   Q+    K R ++      +   E
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE---KMREEERMREREKKMRE 571

Query: 284 NANLQEYVEKETQEKKRLSRTNEELLWK 311
              +    E++ QE++   R  EE +W+
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWE 599



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 53/232 (22%), Positives = 108/232 (46%), Gaps = 27/232 (11%)

Query: 51  QKEKEELERRFEDEVKRLGWQQQAELQELEERLQ-----LQFEAEMARLQEEHGDQLLSI 105
           Q+EK   E++ +++ K+  W Q+ +++E EER++     ++ E EM R QEE        
Sbjct: 532 QEEKMREEKKTQEQEKKT-WDQEEKMRE-EERMREREKKMREEEEMMREQEE-------- 581

Query: 106 RCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKK--ELEEN 163
             + QEQ E +    +    + E          Q++   + +E M   E E K  E EE 
Sbjct: 582 --KMQEQEEKMREQEEKMWEQEEKMQE------QEEKMWEQEEKMWEQEEEDKMQEQEEM 633

Query: 164 FEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRK--NTEEQLEIALAPYQHLEEDMKSL 221
             +    +Q+Q + +  Q + +R++  +  E   K    EE++       Q  EE M+  
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693

Query: 222 KQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQN 273
           ++ +  + +++  QE+K+   E+       + EK + ++ Q E ++ R+ ++
Sbjct: 694 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEH 745



 Score = 37.4 bits (85), Expect = 0.020
 Identities = 43/170 (25%), Positives = 70/170 (41%), Gaps = 31/170 (18%)

Query: 154 ELEKKELEENFEKLRLSLQDQVDT---LTFQSQSL-------RDRARRFEEALRKNTEEQ 203
           E EKK   ++ E LR  ++ Q  T   LT Q   L       +D AR+FE+    N  E 
Sbjct: 70  EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDG---NLGES 126

Query: 204 LEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQN 263
            ++A     H       L++ L   +    + ++ I EL K                 + 
Sbjct: 127 KDLA-GRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTK-----------------ER 168

Query: 264 EDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
           + L   + +NT+   +L ++NA LQE +     EK  +    +EL  KL+
Sbjct: 169 DALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLE 218


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 67/305 (21%), Positives = 143/305 (46%), Gaps = 27/305 (8%)

Query: 16  DKTNESALVKEKELSIELANI-RDEVAFHTAKCEKLQKEK----EELERRFEDEVKRLGW 70
           +K +E   ++E+E   E   + R E   H  +    QKEK    EE  R+ E++V    W
Sbjct: 458 EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV----W 513

Query: 71  QQQAELQELEERLQLQFEA-----EMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALL 125
           +Q+ +++E EE+++ Q E      E  R QEE   +   +  Q +   E+     +  + 
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573

Query: 126 EMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSL 185
             E          Q++   + +E +   E +++E EE   K    +++Q + +  Q + +
Sbjct: 574 RQEEKIRE-----QEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKI 628

Query: 186 RDRARRF--EEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELE 243
           R++  +   +E + +  EE++          EE M+  ++ +  + ++I EQEKKI E E
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688

Query: 244 KLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSR 303
           +       + E+ +++Q+Q E +  + ++      ++ E+   ++   EK  +++ RL +
Sbjct: 689 EK------IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 742

Query: 304 TNEEL 308
             E++
Sbjct: 743 QEEKM 747



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 63/274 (22%), Positives = 133/274 (48%), Gaps = 22/274 (8%)

Query: 48  EKLQKEKE--ELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSI 105
           EK Q+E++  E E+R E E K   W+Q+ +++E EE+++ Q E +M R QEE   +   I
Sbjct: 411 EKRQEEEKIREQEKRQEQEAKM--WRQEEKIREQEEKIREQ-EKKMWR-QEEKIHEQEKI 466

Query: 106 RCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFE 165
           R + + Q ++     +  + E E          Q +  H+ +E +   E +    EE   
Sbjct: 467 REEEKRQEQEEMWRQEEKIHEQEEIWR------QKEKMHEQEEKIRKQEEKVWRQEEKIR 520

Query: 166 KLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVL 225
           +    +++Q + +  Q + +R++   + E  + + +E++       Q  E+ M   ++ +
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE-EKRQEQEDKMWRQEEKI 579

Query: 226 EMKNQQIHEQEKKILELEKLA----EKNIILEEKI----QVLQQQNEDLKARIDQNTVVT 277
             + +++  QE+KI E E+      EK    EEKI    + +Q+Q E ++ + ++     
Sbjct: 580 REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQE 639

Query: 278 RQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
               E+   + E  EK  ++++++ +  EE +W+
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKM-QEQEETMWR 672



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 63/297 (21%), Positives = 135/297 (45%), Gaps = 26/297 (8%)

Query: 23  LVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEER 82
           L+ +++L  E  ++  E+   +AK +  Q E+ EL  R   + +   W+Q+ ++QE EE+
Sbjct: 257 LLPQQQLQAEADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 315

Query: 83  LQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDH 142
           +Q Q   E  R QEE          + +EQ E +    +    + E        + + + 
Sbjct: 316 IQEQ--EEKIREQEE----------KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363

Query: 143 DHKVQELMSTHELEKKELEENF-----EKLRLSLQDQVDTLTFQSQSLRDRARRFEEALR 197
             + QE M   + EK   +E       EK+R     +++    + + +R++  + +E  +
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR-----ELEEKMHEQEKIREQEEKRQEEEK 418

Query: 198 KNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQ 257
              +E+ +   A     EE ++  ++ +  + +++  QE+KI E EK+ E+    E++  
Sbjct: 419 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEM 478

Query: 258 VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYV---EKETQEKKRLSRTNEELLWK 311
             Q++    +  I +      +  E+    +E V   E++ +E++   R  EE +W+
Sbjct: 479 WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWR 535



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 65/297 (21%), Positives = 137/297 (46%), Gaps = 45/297 (15%)

Query: 23  LVKEKE-LSIEL-------ANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQA 74
           L KE++ LS+EL         ++++ A    K + ++ EK E++   ++  ++L      
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL------ 251

Query: 75  ELQELEERLQLQFEAEMARLQEEH-GDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTV 133
                 ER +L    +  + + +H G +L S+  + Q QVE             EN    
Sbjct: 252 ------ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE-------------ENELWN 292

Query: 134 AITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSL--RDRARR 191
            +   Q++   + +E +   E + +E EE   +    +++Q + +  Q + +  ++   R
Sbjct: 293 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352

Query: 192 FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
            +E +    EE++          EE M+  ++++  K ++I E E+K+ E EK+ E+   
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412

Query: 252 LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
            +E+ ++ +Q+      R +Q   + RQ  EE    QE  EK  +++K++ R  E++
Sbjct: 413 RQEEEKIREQEK-----RQEQEAKMWRQ--EEKIREQE--EKIREQEKKMWRQEEKI 460



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 41/164 (25%), Positives = 75/164 (45%), Gaps = 23/164 (14%)

Query: 154 ELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQH 213
           E E+K   ++ E LR  L+ QV T+                  R  T ++ E+ +A Y +
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTI------------------RILTCQKTELQMALY-Y 148

Query: 214 LEEDMKSLKQVLEMKNQQIHEQEKKILELEK----LAEKNIILEEKIQVLQQQNEDLKAR 269
            +  +K L+        ++H+  K   ELE+    +A +    +  I+ L ++ + L   
Sbjct: 149 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 208

Query: 270 IDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
           + +NT+   +L E+NA LQE ++    EK  +    +EL  KL+
Sbjct: 209 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 252


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 70/303 (23%), Positives = 143/303 (47%), Gaps = 26/303 (8%)

Query: 23  LVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEER 82
           L+ +++L +E   +  E+   +AK +  Q E+ EL      + +   W+Q+ ++QE EE+
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKLQA-QVEENELWNLLNQQQEEKMWRQEEKIQEQEEK 312

Query: 83  LQLQF------EAEMARLQEEHGDQLLSIRCQHQE--QVEDLTASHDAALLEMENNHTVA 134
           +  Q       E +M R +E+  +Q   IR Q  +  + E+     +  + E E      
Sbjct: 313 MCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ 372

Query: 135 ITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAR---R 191
              +++  D K+QE       +++++ E  EK +  +  Q   +  Q + +R++     R
Sbjct: 373 EEKIREQ-DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431

Query: 192 FEEALRK------NTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKL 245
            EE +R+      + EE+L       Q  EE M+  ++ ++ + ++I EQE+K    EKL
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491

Query: 246 AEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTN 305
            ++    EEKI    +Q E +  + ++      ++ E+   +Q   EK  +++ RL +  
Sbjct: 492 LKQ----EEKI---WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE 544

Query: 306 EEL 308
           E++
Sbjct: 545 EKM 547



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 62/292 (21%), Positives = 143/292 (48%), Gaps = 15/292 (5%)

Query: 22  ALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEEL---ERRFEDEVKRLGWQQQAELQE 78
           A V+E EL   L   ++E  +     EK+Q+++E++   E +  ++ +++ W+Q+ ++ E
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQE--EKIQEQEEKMCEQELKIREQEEKM-WRQEEKMHE 336

Query: 79  LEERLQLQFEAEMARLQEEHGDQLLSIRCQHQE--QVEDLTASHDAALLEMENNHTVAIT 136
            EE+++ Q E +M R +E+  +Q   IR Q ++  + E+     D  + E E        
Sbjct: 337 QEEKIREQ-EDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEE 395

Query: 137 ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 196
            +++  + K QE M   E + +E +E   +    +  Q + +    + ++D+  +  E  
Sbjct: 396 KIREQEE-KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 197 RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKI 256
            K  EE+ ++     Q  EE ++  ++ ++ + ++   QEK + + EK+ E+   +  + 
Sbjct: 455 EKMQEEEEKM-----QEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE 509

Query: 257 QVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           + + +Q E ++ + ++      ++ E+   L +  EK  +++ RL    E L
Sbjct: 510 EKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 77/314 (24%), Positives = 151/314 (48%), Gaps = 46/314 (14%)

Query: 23  LVKEKEL-SIEL-------ANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQA 74
           L KE++  S+EL         ++++ A    K   ++ EK E++   +D  ++L   ++A
Sbjct: 195 LTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL---ERA 251

Query: 75  ELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVA 134
           +L  L  + QLQ EA+        G +L S+  + Q QVE+        L  + N     
Sbjct: 252 QL--LLPQQQLQVEADRL------GKELQSVSAKLQAQVEE------NELWNLLNQQQEE 297

Query: 135 ITILQDDHDHKVQELMSTHELEKKELEENF----EKL---RLSLQDQVDTLTFQSQSLRD 187
               Q++   + +E M   EL+ +E EE      EK+      +++Q D +  Q + +R+
Sbjct: 298 KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIRE 357

Query: 188 RARRFEEALRK--NTEEQLEIALAPYQHLEEDM----KSLKQVLEMKNQQIHEQEKKILE 241
           +  +  E   K    EE++       Q  EE+M    + +++  E + +++  QEKK+ E
Sbjct: 358 QEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMRE 417

Query: 242 L-EKLAEKNIIL---EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQE 297
             EK+ E+   +   EEKI+ L++  +D + ++ +   V  ++ EE   +QE  EK  ++
Sbjct: 418 QDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLRE---VEEKMQEEEEKMQEQEEKIQRQ 474

Query: 298 KKRLSRTNEELLWK 311
           ++++ +  EE  W+
Sbjct: 475 EEKI-QEQEEKTWR 487



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 64/277 (23%), Positives = 127/277 (45%), Gaps = 51/277 (18%)

Query: 48  EKLQKEKE----ELERRF--EDEVKRLGWQQQAELQELE-ERLQLQFEAEMARLQEEHGD 100
           EKL KE++    EL R    ++E+K    + Q +L+ +E E+ ++Q   +  + + E   
Sbjct: 193 EKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQ 252

Query: 101 QLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKEL 160
            LL    Q Q QVE      D    E+++   V+  +     ++++  L++  + EK   
Sbjct: 253 LLLP---QQQLQVEA-----DRLGKELQS---VSAKLQAQVEENELWNLLNQQQEEKMWR 301

Query: 161 EENFEKLRLSLQDQVDTLTFQSQSLRDRARRF---EEALRKNTEEQLEIALAPYQHLEED 217
           +E        +Q+Q + +  Q   +R++  +    EE + +                EE 
Sbjct: 302 QEE------KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQ---------------EEK 340

Query: 218 MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
           ++  +  +  + ++I EQE+KI E E   EK    EEKI   ++Q+E ++ + ++     
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQE---EKMWRQEEKI---REQDEKIQEQEEEMWRQE 394

Query: 278 RQLSEENANLQEYV---EKETQEKKRLSRTNEELLWK 311
            ++ E+    QE +   EK+ +E+    R  EE +W+
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431



 Score = 35.8 bits (81), Expect = 0.058
 Identities = 56/300 (18%), Positives = 126/300 (42%), Gaps = 44/300 (14%)

Query: 33  LANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMA 92
           L++   ++ FH  K E  Q+ K   +   +   K +  ++  +L E+E  L+ +      
Sbjct: 25  LSDEDSDLDFHINKLE--QQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTK 82

Query: 93  RLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMST 152
           R  E+                +DL  S D+   + E+   V  T+  D+    +++   +
Sbjct: 83  RWDED----------------DDLEESEDSKQCK-ESLKRVTFTLPDDE---AIEDAGVS 122

Query: 153 H-ELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
           H +    E++ +F+K +  + ++  T   +    +   R  E   +K  E  L      +
Sbjct: 123 HVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHF 182

Query: 212 QHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQN-------E 264
            H       ++++ + ++    E  +  +  E+L EKN  L+EK+++++ +        +
Sbjct: 183 DHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVK 242

Query: 265 DLKARIDQNTVVT-------------RQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
           DLK ++++  ++              ++L   +A LQ  VE E +    L++  EE +W+
Sbjct: 243 DLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE-ENELWNLLNQQQEEKMWR 301



 Score = 31.6 bits (70), Expect = 1.1
 Identities = 19/78 (24%), Positives = 37/78 (47%)

Query: 236 EKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKET 295
           E  +LE     +  + +   I+ L ++ +     + +NT+   +L E+NA LQE +    
Sbjct: 172 ENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVE 231

Query: 296 QEKKRLSRTNEELLWKLQ 313
            EK  +    ++L  KL+
Sbjct: 232 SEKSEIQLNVKDLKRKLE 249


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 70/303 (23%), Positives = 143/303 (47%), Gaps = 26/303 (8%)

Query: 23  LVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEER 82
           L+ +++L +E   +  E+   +AK +  Q E+ EL      + +   W+Q+ ++QE EE+
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKLQA-QVEENELWNLLNQQQEEKMWRQEEKIQEQEEK 312

Query: 83  LQLQF------EAEMARLQEEHGDQLLSIRCQHQE--QVEDLTASHDAALLEMENNHTVA 134
           +  Q       E +M R +E+  +Q   IR Q  +  + E+     +  + E E      
Sbjct: 313 MCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQ 372

Query: 135 ITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRAR---R 191
              +++  D K+QE       +++++ E  EK +  +  Q   +  Q + +R++     R
Sbjct: 373 EEKIREQ-DEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431

Query: 192 FEEALRK------NTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKL 245
            EE +R+      + EE+L       Q  EE M+  ++ ++ + ++I EQE+K    EKL
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491

Query: 246 AEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTN 305
            ++    EEKI    +Q E +  + ++      ++ E+   +Q   EK  +++ RL +  
Sbjct: 492 LKQ----EEKI---WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQE 544

Query: 306 EEL 308
           E++
Sbjct: 545 EKM 547



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 78/314 (24%), Positives = 152/314 (48%), Gaps = 46/314 (14%)

Query: 23  LVKEKE-LSIEL-------ANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQA 74
           L KE++ LS+EL         ++++ A    K   ++ EK E++   +D  ++L   ++A
Sbjct: 195 LTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL---ERA 251

Query: 75  ELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVA 134
           +L  L  + QLQ EA+        G +L S+  + Q QVE+        L  + N     
Sbjct: 252 QL--LLPQQQLQVEADRL------GKELQSVSAKLQAQVEE------NELWNLLNQQQEE 297

Query: 135 ITILQDDHDHKVQELMSTHELEKKELEENF----EKL---RLSLQDQVDTLTFQSQSLRD 187
               Q++   + +E M   EL+ +E EE      EK+      +++Q D +  Q + +R+
Sbjct: 298 KMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIRE 357

Query: 188 RARRFEEALRK--NTEEQLEIALAPYQHLEEDM----KSLKQVLEMKNQQIHEQEKKILE 241
           +  +  E   K    EE++       Q  EE+M    + +++  E + +++  QEKK+ E
Sbjct: 358 QEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMRE 417

Query: 242 L-EKLAEKNIIL---EEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQE 297
             EK+ E+   +   EEKI+ L++  +D + ++ +   V  ++ EE   +QE  EK  ++
Sbjct: 418 QDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLRE---VEEKMQEEEEKMQEQEEKIQRQ 474

Query: 298 KKRLSRTNEELLWK 311
           ++++ +  EE  W+
Sbjct: 475 EEKI-QEQEEKTWR 487



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 62/292 (21%), Positives = 143/292 (48%), Gaps = 15/292 (5%)

Query: 22  ALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEEL---ERRFEDEVKRLGWQQQAELQE 78
           A V+E EL   L   ++E  +     EK+Q+++E++   E +  ++ +++ W+Q+ ++ E
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQE--EKIQEQEEKMCEQELKIREQEEKM-WRQEEKMHE 336

Query: 79  LEERLQLQFEAEMARLQEEHGDQLLSIRCQHQE--QVEDLTASHDAALLEMENNHTVAIT 136
            EE+++ Q E +M R +E+  +Q   IR Q ++  + E+     D  + E E        
Sbjct: 337 QEEKIREQ-EDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEE 395

Query: 137 ILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEAL 196
            +++  + K QE M   E + +E +E   +    +  Q + +    + ++D+  +  E  
Sbjct: 396 KIREQEE-KRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 197 RKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKI 256
            K  EE+ ++     Q  EE ++  ++ ++ + ++   QEK + + EK+ E+   +  + 
Sbjct: 455 EKMQEEEEKM-----QEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQE 509

Query: 257 QVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           + + +Q E ++ + ++      ++ E+   L +  EK  +++ RL    E L
Sbjct: 510 EKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 62/277 (22%), Positives = 125/277 (45%), Gaps = 51/277 (18%)

Query: 48  EKLQKEKEELERRF------EDEVKRLGWQQQAELQELE-ERLQLQFEAEMARLQEEHGD 100
           EKL KE++ L          ++E+K    + Q +L+ +E E+ ++Q   +  + + E   
Sbjct: 193 EKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQ 252

Query: 101 QLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKEL 160
            LL    Q Q QVE      D    E+++   V+  +     ++++  L++  + EK   
Sbjct: 253 LLLP---QQQLQVEA-----DRLGKELQS---VSAKLQAQVEENELWNLLNQQQEEKMWR 301

Query: 161 EENFEKLRLSLQDQVDTLTFQSQSLRDRARRF---EEALRKNTEEQLEIALAPYQHLEED 217
           +E        +Q+Q + +  Q   +R++  +    EE + +                EE 
Sbjct: 302 QEE------KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQ---------------EEK 340

Query: 218 MKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVT 277
           ++  +  +  + ++I EQE+KI E E   EK    EEKI   ++Q+E ++ + ++     
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQE---EKMWRQEEKI---REQDEKIQEQEEEMWRQE 394

Query: 278 RQLSEENANLQEYV---EKETQEKKRLSRTNEELLWK 311
            ++ E+    QE +   EK+ +E+    R  EE +W+
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431



 Score = 35.4 bits (80), Expect = 0.076
 Identities = 56/300 (18%), Positives = 126/300 (42%), Gaps = 44/300 (14%)

Query: 33  LANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMA 92
           L++   ++ FH  K E  Q+ K   +   +   K +  ++  +L E+E  L+ +      
Sbjct: 25  LSDEDSDLDFHINKLE--QQSKVRNKGHGKPREKSIADEKFFQLSEMEAYLENRKRRGTK 82

Query: 93  RLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMST 152
           R  E+                +DL  S D+   + E+   V  T+  D+    +++   +
Sbjct: 83  RWDED----------------DDLEESEDSKQCK-ESLKRVTFTLPDDE---AIEDAGVS 122

Query: 153 H-ELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPY 211
           H +    E++ +F+K +  + ++  T   +    +   R  E   +K  E  L      +
Sbjct: 123 HVKKNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHF 182

Query: 212 QHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQN-------E 264
            H       ++++ + ++    E  +  +  E+L EKN  L+EK+++++ +        +
Sbjct: 183 DHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVK 242

Query: 265 DLKARIDQNTVVT-------------RQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
           DLK ++++  ++              ++L   +A LQ  VE E +    L++  EE +W+
Sbjct: 243 DLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE-ENELWNLLNQQQEEKMWR 301



 Score = 34.3 bits (77), Expect = 0.17
 Identities = 20/78 (25%), Positives = 38/78 (48%)

Query: 236 EKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKET 295
           E  +LE     +  + +   I+ L ++ + L   + +NT+   +L E+NA LQE +    
Sbjct: 172 ENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVE 231

Query: 296 QEKKRLSRTNEELLWKLQ 313
            EK  +    ++L  KL+
Sbjct: 232 SEKSEIQLNVKDLKRKLE 249


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 63/304 (20%), Positives = 143/304 (47%), Gaps = 28/304 (9%)

Query: 20  ESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKE---------ELERRFEDEVKRLGW 70
           E  + +++E+  E      E+     + EK+++++E         E E+R E E K   W
Sbjct: 423 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM--W 480

Query: 71  QQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQ-----VEDLTASHDAALL 125
           +Q+ +++E EE+++ Q E    + ++ H  + +    + QEQ      E+     +    
Sbjct: 481 RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR 540

Query: 126 EMENNHTVAITI-LQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQS 184
           + E  H     I  Q++   + +E M   E + +E EE   +    +++Q + +  Q + 
Sbjct: 541 QKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK 600

Query: 185 LRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEK 244
           +R++    +E   K  E++ ++        EE M+  ++ +  + ++I EQEKKI E E+
Sbjct: 601 IREQEEMTQEQEEKMGEQEEKMC-----EQEEKMQEQEEKMRRQEEKIREQEKKIREQEE 655

Query: 245 LAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRT 304
                  + E+ +++Q+Q E +  + ++      ++ E+   ++   EK  +++ RL + 
Sbjct: 656 K------IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 709

Query: 305 NEEL 308
            E++
Sbjct: 710 EEKM 713



 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 61/256 (23%), Positives = 124/256 (48%), Gaps = 27/256 (10%)

Query: 17  KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAEL 76
           +  E  + +++E   E   IR+E        EK Q+++E   +  +   +   W+Q+ ++
Sbjct: 494 REQEEKMWRQEEKIHEQEKIREE--------EKRQEQEEMWRQEEKIREQEEIWRQKEKI 545

Query: 77  QELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAIT 136
            E EE+++ Q E +M R +E+  DQ   IR Q     E+     +  + E E        
Sbjct: 546 HEQEEKIRKQ-EEKMWRQEEKMHDQEEKIREQ-----EEKVWRQEEKIREQEEK------ 593

Query: 137 ILQDDHDHKVQELMSTHELEKK-ELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEA 195
           I + +   + QE M+  + EK  E EE   +    +Q+Q + +  Q + +R++ ++  E 
Sbjct: 594 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ 653

Query: 196 LRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKIL-ELEKLAEKNIILEE 254
             K  E++  +     Q  EE M   ++ +  + +++ EQE+K+  + EK+ E+ + L +
Sbjct: 654 EEKIREQEEMM-----QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 708

Query: 255 KIQVLQQQNEDLKARI 270
           + + +Q+  E L+A I
Sbjct: 709 QEEKMQEHQEHLEAAI 724



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 66/299 (22%), Positives = 136/299 (45%), Gaps = 44/299 (14%)

Query: 23  LVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEER 82
           L+ +++L  E  ++  E+   +AK +  Q E+ EL  R   + +   W+Q+ ++QE EE+
Sbjct: 318 LLPQQQLQAEADHLGKELQSVSAKLQA-QVEENELWNRLNQQQEEKMWRQEEKIQEWEEK 376

Query: 83  LQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDH 142
           +Q Q   E  R QEE          + +EQ E +    +    + E        + + + 
Sbjct: 377 IQEQ--EEKIREQEE----------KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 424

Query: 143 DHKVQELMSTHELEK-KELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTE 201
             + QE M   + EK +ELEE                  + + +R++  + +E  +   +
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMH---------------EQEKIREQEEKRQEEEKIREQ 469

Query: 202 EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 261
           E+ +   A     EE ++  ++ +  + +++  QE+KI E EK+ E     EEK Q  Q+
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE-----EEKRQE-QE 523

Query: 262 QNEDLKARIDQNTVVTRQ---LSEENANLQEYVEKETQEKKRLS------RTNEELLWK 311
           +    + +I +   + RQ   + E+   +++  EK  ++++++       R  EE +W+
Sbjct: 524 EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWR 582



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 65/295 (22%), Positives = 136/295 (46%), Gaps = 55/295 (18%)

Query: 23  LVKEKE-LSIEL-------ANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQA 74
           L KE++ LS+EL         ++++ A    K + ++ EK E++   ++  ++L      
Sbjct: 259 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL------ 312

Query: 75  ELQELEERLQLQFEAEMARLQEEH-GDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTV 133
                 ER +L    +  + + +H G +L S+  + Q QVE             EN    
Sbjct: 313 ------ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE-------------ENELWN 353

Query: 134 AITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFE 193
            +   Q++   + +E +   E + +E EE   +    +++Q + +  Q + + ++    E
Sbjct: 354 RLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEK----E 409

Query: 194 EALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILE 253
           E +R+  E   E         EE M+  ++++  K ++I E E+K+ E EK+ E+    +
Sbjct: 410 EKMRRQEEMMWE--------KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 461

Query: 254 EKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
           E+ ++ +Q+      R +Q   + RQ  EE    QE  EK  ++++++ R  E++
Sbjct: 462 EEEKIREQEK-----RQEQEAKMWRQ--EEKIREQE--EKIREQEEKMWRQEEKI 507



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 41/164 (25%), Positives = 75/164 (45%), Gaps = 23/164 (14%)

Query: 154 ELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQH 213
           E E+K   ++ E LR  L+ QV T+                  R  T ++ E+ +A Y +
Sbjct: 169 EDEQKASHQHQEALRRELEAQVHTI------------------RILTCQKTELQMALY-Y 209

Query: 214 LEEDMKSLKQVLEMKNQQIHEQEKKILELEK----LAEKNIILEEKIQVLQQQNEDLKAR 269
            +  +K L+        ++H+  K   ELE+    +A +    +  I+ L ++ + L   
Sbjct: 210 SQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLE 269

Query: 270 IDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
           + +NT+   +L E+NA LQE ++    EK  +    +EL  KL+
Sbjct: 270 LYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 313


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 66/307 (21%), Positives = 148/307 (48%), Gaps = 28/307 (9%)

Query: 24  VKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFE-----------DEVKRLGWQQ 72
           +  +EL  + A +++++    ++  ++Q   +EL+R+ E           + ++   W+Q
Sbjct: 218 ITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 277

Query: 73  QAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQE--QVEDLTASHDAALLEMENN 130
           + EL+E E++++ Q E +M R +E   +Q   +R Q ++  + E      +  L E E  
Sbjct: 278 EEELREQEKKIRKQ-EEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKE 336

Query: 131 HTVAITIL-QDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRA 189
                 +  Q++   + +E M   E + +E EE   +    L +Q   +  Q Q +RD+ 
Sbjct: 337 LREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 396

Query: 190 RRF---EEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQ--IHEQEKKILELEK 244
            R    +E LR+  E   E      + + E ++ +++  +M+ Q+    +QE+K+ E E+
Sbjct: 397 ERMWEQDERLREKEERMRE-----QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451

Query: 245 LAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRT 304
           + E+   + E+ + +++Q E ++ + ++N     +   +   L E  EK  +++K   + 
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQ-EENMWEQEEKEWQQQRLPEQKEKLWEQEK--MQE 508

Query: 305 NEELLWK 311
            EE +W+
Sbjct: 509 QEEKIWE 515



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 66/305 (21%), Positives = 145/305 (47%), Gaps = 27/305 (8%)

Query: 16  DKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAE 75
           +K  E   ++E+E       +R+E      + EK+QK++E +  + E E     WQQQ  
Sbjct: 444 EKMQEEERIRERE-----KKMREEEETMREQEEKMQKQEENMWEQEEKE-----WQQQ-R 492

Query: 76  LQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAI 135
           L E +E+L  Q   +M   +E+  +Q   IR Q +   ++        + E E+      
Sbjct: 493 LPEQKEKLWEQ--EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 550

Query: 136 TILQD------DHDHKV------QELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ 183
             ++D      D + ++      QE  +  + EK   EE   +    ++++ + +  Q +
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610

Query: 184 SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQ-IHEQEKKILEL 242
            ++++  + +E   K  E++ ++     +  E++ K  +Q  +M  QQ + EQ++K+ E 
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670

Query: 243 EKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLS 302
           EK+ E+  + E++ ++ +Q+  + K +  +     ++   E  +++E  EK+ +E++ + 
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER-EKKMREEEEMM 729

Query: 303 RTNEE 307
           R  EE
Sbjct: 730 REQEE 734



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 66/332 (19%), Positives = 158/332 (47%), Gaps = 39/332 (11%)

Query: 17  KTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKE-----------------ELER 59
           +  E  L ++KEL  +   ++++      + EK+++++E                 E E+
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390

Query: 60  RFEDEVKRLGWQQQAELQELEERLQLQFE--AEMARLQEEHGDQLLSIRCQHQE---QVE 114
           +  D+ +R+ W+Q   L+E EER++ Q +   ++ +++EE   Q    + + QE   Q E
Sbjct: 391 KMRDQEERM-WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449

Query: 115 DLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKL--RLSLQ 172
           +     +  + E E         +Q   ++  ++     E +++ L E  EKL  +  +Q
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQ--EEKEWQQQRLPEQKEKLWEQEKMQ 507

Query: 173 DQVDTLTFQSQSLRDR-------ARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVL 225
           +Q + +  Q + +RD+        + + +   +  E+Q+       +  E+ M   ++ +
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567

Query: 226 EMKNQQ----IHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLS 281
           E K Q+      +QE+K+ E E++ E+   + E+ +++++Q E ++ + ++      ++ 
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627

Query: 282 EENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
           E+   +QE  EK  ++++++    EE +W+ Q
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWE-QEEKMWEQQ 658



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 54/213 (25%), Positives = 105/213 (49%), Gaps = 22/213 (10%)

Query: 113 VEDLTASHDAALLEMENNHTVAITILQDDHDHK---VQELMSTHELEKKELEENFEKLRL 169
           +E+LT   DA  LE+  N     TI  ++   K   +QE +   E EK E++ N ++L+ 
Sbjct: 199 IEELTKERDALSLELYRN-----TITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKR 253

Query: 170 SLQ------DQVDTLTFQSQSLR--DRARRFEEALRKNTE------EQLEIALAPYQHLE 215
            L+       QV T T Q +  R  +  R  E+ +RK  E      E+L       +  E
Sbjct: 254 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE 313

Query: 216 EDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTV 275
           E M   ++ L  + +++ EQEK++ E ++L E+   ++E+ + + +Q E ++ + ++   
Sbjct: 314 EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWR 373

Query: 276 VTRQLSEENANLQEYVEKETQEKKRLSRTNEEL 308
              +L E+   ++E  +K   +++R+   +E L
Sbjct: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406



 Score = 55.5 bits (132), Expect = 7e-08
 Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 56/297 (18%)

Query: 16  DKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAE 75
           +K  E   ++E+E       +R+E      + EK+Q+++E+++   E E K   W+Q+ +
Sbjct: 583 EKMREEERMRERE-----KKMREEEEMMREQEEKMQEQEEKMQ---EQEEKM--WEQEEK 632

Query: 76  LQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAI 135
           +QE EE++  Q E +M   +E+  +Q      +  EQ E L                   
Sbjct: 633 MQEQEEKMWEQ-EEKMWEQEEKMWEQQ-----RLPEQKEKLW------------------ 668

Query: 136 TILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEA 195
                +H+ K+QE     E E+K  E+  EK+    Q+Q      Q +   + + R  E 
Sbjct: 669 -----EHE-KMQEQEKMQEQEEKIWEQ--EKMEKKTQEQEKKTWDQEKMREEESMREREK 720

Query: 196 LRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIIL--E 253
             +  EE +       Q  EE M+  ++ +  + +++ EQE+K+ E ++L E+   L   
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780

Query: 254 EKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLW 310
           EK+Q  ++  E  +   DQ         EE    QE   +  +EK    R  EE +W
Sbjct: 781 EKMQEQEKIWEQEEKMRDQ---------EEKMRGQEEKMRGQEEK---MRGQEEKMW 825



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 69/339 (20%), Positives = 145/339 (42%), Gaps = 47/339 (13%)

Query: 16  DKTNESALVKEKELSIELAN-IRDEVAFHTAKCEKLQKEKE--ELERRFEDEVKRLGWQQ 72
           +K+     VKE +  +E A  +  +V  +T + E  ++E+E  E E++   + +++ W+Q
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM-WRQ 298

Query: 73  QAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHT 132
           +  L+E E +++ Q E +M R ++   +Q   +R Q +E  E          ++ +    
Sbjct: 299 EERLREQEGKMREQ-EEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357

Query: 133 VAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRF 192
                 Q++   + +E M   E    E E+   +    ++DQ + +  Q + LR++  R 
Sbjct: 358 WE----QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM 413

Query: 193 EEALR------------------KNT---------EEQLEIALAPYQHLEEDMKSLKQVL 225
            E  +                  K T         EE++       +  EE M+  ++ +
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM 473

Query: 226 EMKNQQIHEQEKKILELEKLAEKNIIL---------EEKIQVLQQQNEDLKARIDQNTVV 276
           + + + + EQE+K  + ++L E+   L         EEKI   +++  D +    Q   +
Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533

Query: 277 TRQ--LSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
            RQ  + E+   + E  EK   +++++    E +  K Q
Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ 572



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 53/224 (23%), Positives = 103/224 (45%), Gaps = 37/224 (16%)

Query: 48  EKLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRC 107
           EK++K+ +E E++  D+ K    +++  ++E E++++   E EM R QEE          
Sbjct: 690 EKMEKKTQEQEKKTWDQEKM---REEESMREREKKMRE--EEEMMREQEE---------- 734

Query: 108 QHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHEL--EKKELEENFE 165
           + QEQ E +    +    + E        + +     + +E +  HE   E++++ E  E
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794

Query: 166 KLRLSLQDQVDTLTFQSQSLR---DRARRFEEALRKNTEE----------QLEIALAPYQ 212
           K+R    DQ + +  Q + +R   ++ R  EE +    E+          Q E      +
Sbjct: 795 KMR----DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEE 850

Query: 213 HLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKI 256
            +EE M+  ++ +  + +++  QE+K+ E E   EK    EEKI
Sbjct: 851 KMEEKMQGQEEKMREQEEKMRGQEEKMREQE---EKMRGQEEKI 891



 Score = 36.6 bits (83), Expect = 0.034
 Identities = 41/176 (23%), Positives = 74/176 (42%), Gaps = 19/176 (10%)

Query: 156 EKKELEENFEKLRLSLQDQVDT---LTFQSQSL-------RDRARRFEEALRKNTEEQLE 205
           EKK   ++ E LR  ++ Q  T   LT Q   L       +D AR+FE+     T     
Sbjct: 82  EKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDG-NLGTPSSFN 140

Query: 206 IALA------PYQHLEEDM--KSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQ 257
           +AL+      P   +   +     K +    +   H   +    L  ++ ++   +  I+
Sbjct: 141 LALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIE 200

Query: 258 VLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQ 313
            L ++ + L   + +NT+   +L ++NA LQE +     EK  +    +EL  KL+
Sbjct: 201 ELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLE 256


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 68.6 bits (166), Expect = 8e-12
 Identities = 97/361 (26%), Positives = 162/361 (44%), Gaps = 75/361 (20%)

Query: 3   HCCCKPY------NCLQCLDKTNESALV--------KEKELSIELA---NIRDEVAFHTA 45
           HCC +         C+ C+   N +  +        +E   +I++A       + + H  
Sbjct: 265 HCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKD 324

Query: 46  KCEKLQKEKEELERRF---EDEVKRLGWQQQAE---LQELEERLQLQFEAEMARLQEEHG 99
             +K ++++E+ ERR    E+E+ RL   Q+ +   LQELE   + Q +AE   LQEE  
Sbjct: 325 LKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERL-LQEEEE 383

Query: 100 DQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKE 159
            +    R QH+E  + L    +  L E E     A   +Q + + K +E     +   KE
Sbjct: 384 RR----RSQHRELQQAL----EGQLREAEQ----ARASMQAEMELKEEEAARQRQ-RIKE 430

Query: 160 LEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMK 219
           LEE  ++L+ +LQ +V            +ARR EE++R          +A  + LEE+ +
Sbjct: 431 LEEMQQRLQEALQLEV------------KARRDEESVR----------IAQTRLLEEEEE 468

Query: 220 SLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQ 279
            LKQ++++K +Q    E+   E E+L ++       +Q  QQQ E+++    QN    RQ
Sbjct: 469 KLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVR----QN----RQ 520

Query: 280 LSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSS 339
            ++E+        +  Q K R + TN +  W +Q      PI+     PV   S SG   
Sbjct: 521 RADEDV-------EAAQRKLRQASTNVK-HWNVQMNRLMHPIEPGDKRPVTSSSFSGFQP 572

Query: 340 P 340
           P
Sbjct: 573 P 573


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,054,037
Number of Sequences: 37866
Number of extensions: 644708
Number of successful extensions: 12449
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 431
Number of HSP's successfully gapped in prelim test: 1070
Number of HSP's that attempted gapping in prelim test: 5224
Number of HSP's gapped (non-prelim): 4704
length of query: 348
length of database: 18,247,518
effective HSP length: 103
effective length of query: 245
effective length of database: 14,347,320
effective search space: 3515093400
effective search space used: 3515093400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.