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Search of human proteins with 57222269
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
(315 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens] 644 0.0
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 461 e-130
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 362 e-100
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 303 1e-82
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 303 1e-82
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 279 2e-75
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 279 2e-75
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 222 3e-58
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 218 4e-57
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 209 2e-54
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 209 2e-54
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 207 7e-54
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 201 7e-52
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 195 5e-50
gi|27477122 intestinal cell kinase [Homo sapiens] 187 1e-47
gi|7662388 intestinal cell kinase [Homo sapiens] 187 1e-47
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 186 3e-47
gi|11496279 male germ cell-associated kinase [Homo sapiens] 185 4e-47
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 184 7e-47
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 184 7e-47
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 182 3e-46
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 182 3e-46
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 182 3e-46
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 182 4e-46
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 181 6e-46
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 181 7e-46
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 181 7e-46
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 181 7e-46
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 181 7e-46
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 181 7e-46
>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
Length = 315
Score = 644 bits (1662), Expect = 0.0
Identities = 315/315 (100%), Positives = 315/315 (100%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH
Sbjct: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH
Sbjct: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
Query: 181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP 240
SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP
Sbjct: 181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP 240
Query: 241 EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARN 300
EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARN
Sbjct: 241 EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARN 300
Query: 301 EGRNRRRQQVLPLKS 315
EGRNRRRQQVLPLKS
Sbjct: 301 EGRNRRRQQVLPLKS 315
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 461 bits (1185), Expect = e-130
Identities = 213/302 (70%), Positives = 254/302 (84%), Gaps = 1/302 (0%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
MEKYEK+ K GEGSYGVVFKCRN+ +GQ+VA+KKF+ESEDDPV+KKIALREIRMLKQLKH
Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
PNLVNL+EVFRRKR++HLVFEYCDHT+L+EL+R GV + ++KS+ WQTLQA+NFCH H
Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILI-PGDAYTDYVATRWYRAPELLVGDTQYG 179
NCIHRD+KPENILITK +IK+CDFGFA++L P D YTDYVATRWYR+PELLVGDTQYG
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
VD+WAIGCVFAELL+G PLWPGKSDVDQLYLI +TLG LIPRHQ +F +N +F G+ I
Sbjct: 182 PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI 241
Query: 240 PEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKAR 299
P+PEDME LE KF ++ AL +KGCL M+P RLTC QLL YF++ +E + K
Sbjct: 242 PDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEH 301
Query: 300 NE 301
N+
Sbjct: 302 NK 303
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 362 bits (930), Expect = e-100
Identities = 171/318 (53%), Positives = 236/318 (74%), Gaps = 10/318 (3%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
MEKYE L GEGSYG+V KCRNK +G++VA+KKF+ES+DD +VKKIA+REI++LKQL+H
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
NLVNL+EV ++K++ +LVFE+ DHT+L++LE PNG+ V++ L+Q + + FCH H
Sbjct: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYG 179
N IHRDIKPENIL+++ G++K+CDFGFA+ L PG+ YTDYVATRWYRAPELLVGD +YG
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
+VD+WAIGC+ E+ G+PL+PG SD+DQLY I+ LG LIPRHQ +F N F G+ +
Sbjct: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
Query: 240 PEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF--DSF-----QEA 292
PE ++ E LE ++ + V ++ K CL ++PD R C++LL +F D F QE
Sbjct: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
Query: 293 QIK--RKARNEGRNRRRQ 308
Q+K + ARN +++ Q
Sbjct: 301 QLKVQKDARNVSLSKKSQ 318
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 303 bits (777), Expect = 1e-82
Identities = 150/309 (48%), Positives = 211/309 (68%), Gaps = 7/309 (2%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
ME YE L K GEGSYG V KC++K +GQ+VA+K F E + V KIA+REI+ LKQ H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSV-NKIAMREIKFLKQFHH 59
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
NLVNLIEVFR+K+K+HLVFE+ DHT+L+EL+ +G+ ++ L+Q L+A+++ H +
Sbjct: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYG 179
N IHRDIKPENIL+++ GI K+CDFGFA+ L PGD YTDYVATRWYRAPEL++ DT YG
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
VDIWA+GC+ E+ TG P P SD+D L+ I+ +G L P Q+IF + F G+ +
Sbjct: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
Query: 240 PEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF--DSFQE---AQI 294
P+ + + +K+ ++ + + + CL+++P DR++ S LL YF D F E ++
Sbjct: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 299
Query: 295 KRKARNEGR 303
K K E +
Sbjct: 300 KAKLLQEAK 308
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 303 bits (777), Expect = 1e-82
Identities = 150/309 (48%), Positives = 211/309 (68%), Gaps = 7/309 (2%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
ME YE L K GEGSYG V KC++K +GQ+VA+K F E + V KIA+REI+ LKQ H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSV-NKIAMREIKFLKQFHH 59
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
NLVNLIEVFR+K+K+HLVFE+ DHT+L+EL+ +G+ ++ L+Q L+A+++ H +
Sbjct: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYG 179
N IHRDIKPENIL+++ GI K+CDFGFA+ L PGD YTDYVATRWYRAPEL++ DT YG
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
VDIWA+GC+ E+ TG P P SD+D L+ I+ +G L P Q+IF + F G+ +
Sbjct: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
Query: 240 PEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF--DSFQE---AQI 294
P+ + + +K+ ++ + + + CL+++P DR++ S LL YF D F E ++
Sbjct: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 299
Query: 295 KRKARNEGR 303
K K E +
Sbjct: 300 KAKLLQEAK 308
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 279 bits (714), Expect = 2e-75
Identities = 136/291 (46%), Positives = 199/291 (68%), Gaps = 4/291 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
M K+E L GEG+YGVV KCR+K + ++VA+KKF +SE++ VK+ LRE++ML+ LK
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L E FRR+ K++LVFEY + +L LE PNGV +KS ++Q ++A+++CH +
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGD--AYTDYVATRWYRAPELLVGDTQY 178
+ +HRDIKPEN+LI+ ++K+CDFGFA+ L G+ YT+YVATRWYR+PELL+G Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
Query: 179 GSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGIS 238
G SVD+W++GC+ EL GQPL+PG+S++DQL+ I + LG L +F SN FHG+
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 239 IPEPEDMETLEEKFSDV-HPVALNFMKGCLKMNPDDRLTCSQLLESSYFDS 288
P ++LE ++ + + V L+ MK LK++P DR Q L F +
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 279 bits (714), Expect = 2e-75
Identities = 136/291 (46%), Positives = 199/291 (68%), Gaps = 4/291 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
M K+E L GEG+YGVV KCR+K + ++VA+KKF +SE++ VK+ LRE++ML+ LK
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L E FRR+ K++LVFEY + +L LE PNGV +KS ++Q ++A+++CH +
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGD--AYTDYVATRWYRAPELLVGDTQY 178
+ +HRDIKPEN+LI+ ++K+CDFGFA+ L G+ YT+YVATRWYR+PELL+G Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
Query: 179 GSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGIS 238
G SVD+W++GC+ EL GQPL+PG+S++DQL+ I + LG L +F SN FHG+
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 239 IPEPEDMETLEEKFSDV-HPVALNFMKGCLKMNPDDRLTCSQLLESSYFDS 288
P ++LE ++ + + V L+ MK LK++P DR Q L F +
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 222 bits (566), Expect = 3e-58
Identities = 120/306 (39%), Positives = 186/306 (60%), Gaps = 18/306 (5%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
M+ ++K+ K GEG+YGVV+K +N+ +GQ+VA+KK + V A+REI +LK+LKH
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNG-VADGVIKSVLWQTLQALNFCHI 119
PN+V L++V +RK++LVFE+ L ++ P + +IKS L+Q LQ ++FCH
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 120 HNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQY 178
H IHRD+KP+N+LI + G IK+ DFG A+ +P YT V T WYRAPE+L+G Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 179 GSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGIS 238
++VDIW+IGC+FAE++T + L+PG S++DQL+ I R LG S + G++
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGT---------PSEDTWPGVT 231
Query: 239 -IPEPE------DMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQE 291
+P+ + + LEE ++ P + + L+ +P R+T L YF S +
Sbjct: 232 QLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEP 291
Query: 292 AQIKRK 297
+ R+
Sbjct: 292 SPAARQ 297
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 218 bits (556), Expect = 4e-57
Identities = 105/220 (47%), Positives = 152/220 (69%), Gaps = 2/220 (0%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
ME ++K+ K GEG+YGVV+K RNK +G+VVA+KK + V A+REI +LK+L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNP-NGVADGVIKSVLWQTLQALNFCHI 119
PN+V L++V + K++LVFE+ L ++ + G+ +IKS L+Q LQ L FCH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 120 HNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQY 178
H +HRD+KP+N+LI +G IK+ DFG A+ +P YT V T WYRAPE+L+G Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 179 GSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218
++VDIW++GC+FAE++T + L+PG S++DQL+ I RTLG
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLG 220
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 209 bits (533), Expect = 2e-54
Identities = 104/221 (47%), Positives = 150/221 (67%), Gaps = 3/221 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
ME Y K+ K GEG+YGVV+K R+KT+GQVVA+KK ++ V A+REI +LK+L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNG--VADGVIKSVLWQTLQALNFCH 118
PN+V+L +V + +++L+FE+ L L+ P G + ++KS L+Q LQ + FCH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 119 IHNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQ 177
+HRD+KP+N+LI +G IK+ DFG A+ IP YT V T WYR+PE+L+G +
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 178 YGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218
Y + VDIW+IG +FAEL T +PL+ G S++DQL+ I R LG
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 209 bits (533), Expect = 2e-54
Identities = 114/292 (39%), Positives = 168/292 (57%), Gaps = 6/292 (2%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
M+KYEKL K GEG+YG VFK +N+ + ++VA+K+ +DD V ALREI +LK+LKH
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L +V +K+ LVFE+CD L + + ++KS L+Q L+ L FCH
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYG 179
N +HRD+KP+N+LI + G +K+ DFG A+ IP Y+ V T WYR P++L G Y
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 180 SSVDIWAIGCVFAELL-TGQPLWPGKSDVDQLYLIIRTLGKLIPRH-QSIFKSNGFFHGI 237
+S+D+W+ GC+FAEL G+PL+PG DQL I R LG S+ K +
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP 240
Query: 238 SIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSF 289
P + + K ++ + ++ LK NP R++ + L+ YF F
Sbjct: 241 MYPATTSLVNVVPK---LNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 289
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 207 bits (528), Expect = 7e-54
Identities = 103/221 (46%), Positives = 149/221 (67%), Gaps = 3/221 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
ME Y K+ K GEG+YGVV+K R+KT+GQVVA+KK ++ V A+REI +LK+L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNG--VADGVIKSVLWQTLQALNFCH 118
PN+V+L +V + +++L+FE+ L L+ P G + ++KS L+Q LQ + FCH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 119 IHNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQ 177
+HRD+KP+N+LI +G IK+ DFG A+ IP YT T WYR+PE+L+G +
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 178 YGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218
Y + VDIW+IG +FAEL T +PL+ G S++DQL+ I R LG
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 201 bits (511), Expect = 7e-52
Identities = 117/301 (38%), Positives = 168/301 (55%), Gaps = 27/301 (8%)
Query: 2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFV---ESEDDPVVKKIALREIRMLKQL 58
++YEKL GEG + V+K R+K + Q+VA+KK SE + + ALREI++L++L
Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69
Query: 59 KHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCH 118
HPN++ L++ F K + LVF++ + L ++ N + IK+ + TLQ L + H
Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLH 129
Query: 119 IHNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQ 177
H +HRD+KP N+L+ + G++K+ DFG A+ P AYT V TRWYRAPELL G
Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189
Query: 178 YGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGK----------LIPRHQSI 227
YG VD+WA+GC+ AELL P PG SD+DQL I TLG +P + +
Sbjct: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT- 248
Query: 228 FKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFD 287
FKS F GI L FS L+ ++G NP R+T +Q L+ YF
Sbjct: 249 FKS---FPGI---------PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296
Query: 288 S 288
+
Sbjct: 297 N 297
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 195 bits (495), Expect = 5e-50
Identities = 111/289 (38%), Positives = 163/289 (56%), Gaps = 4/289 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK- 59
M++Y L + GEG++G+VFK ++ +G++VA+KK + ALREI+ L++++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 60 HPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHI 119
+ +V L VF L FE+ L + +A +KS L L+ + FCH
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 120 HNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDA--YTDYVATRWYRAPELLVGDTQ 177
+N +HRD+KP N+LI+ G +KI DFG A++ P + YT VATRWYRAPELL G Q
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 178 YGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGI 237
Y VD+W++GC+ ELL G PL+PGK+D++QL ++R LG P+ ++ I
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 238 SIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF 286
S E M LEE DV P AL+ + L P R+ S+ L YF
Sbjct: 241 SFKEQVPM-PLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 187 bits (474), Expect = 1e-47
Identities = 99/287 (34%), Positives = 163/287 (56%), Gaps = 4/287 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
M +Y + + G+G+YG V R+ SG+++A+KK ++ + + + LRE++ LK+L H
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKK-MKRKFYSWEECMNLREVKSLKKLNH 59
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L EV R ++ +FEY L ++ + I+++++Q LQ L F H H
Sbjct: 60 ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKH 119
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
HRD+KPEN+L ++KI DFG A+ + YTDYV+TRWYRAPE+L+ T Y S
Sbjct: 120 GFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSS 179
Query: 181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP 240
+D+WA+GC+ AE+ T +PL+PG S++D ++ I + LG P+ + ++
Sbjct: 180 PIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLG--TPKKTDWPEGYQLSSAMNFR 237
Query: 241 EPEDM-ETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF 286
P+ + L+ + A+ ++ L+ +P R T SQ L YF
Sbjct: 238 WPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 187 bits (474), Expect = 1e-47
Identities = 99/287 (34%), Positives = 163/287 (56%), Gaps = 4/287 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
M +Y + + G+G+YG V R+ SG+++A+KK ++ + + + LRE++ LK+L H
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKK-MKRKFYSWEECMNLREVKSLKKLNH 59
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L EV R ++ +FEY L ++ + I+++++Q LQ L F H H
Sbjct: 60 ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKH 119
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGS 180
HRD+KPEN+L ++KI DFG A+ + YTDYV+TRWYRAPE+L+ T Y S
Sbjct: 120 GFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSS 179
Query: 181 SVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIP 240
+D+WA+GC+ AE+ T +PL+PG S++D ++ I + LG P+ + ++
Sbjct: 180 PIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLG--TPKKTDWPEGYQLSSAMNFR 237
Query: 241 EPEDM-ETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF 286
P+ + L+ + A+ ++ L+ +P R T SQ L YF
Sbjct: 238 WPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 186 bits (471), Expect = 3e-47
Identities = 103/289 (35%), Positives = 161/289 (55%), Gaps = 4/289 (1%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
++++EKL + GEG+YG+V++ R+ + ++VA+KK ++ + +LREI +L +L+H
Sbjct: 36 VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95
Query: 61 PNLVNLIEVF--RRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCH 118
PN+V L EV + LV YC+ L + LE P ++ +K ++ Q L+ L + H
Sbjct: 96 PNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLH 155
Query: 119 IHNCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQ 177
+ IHRD+K N+L+T +G +K DFG A+ +P T V T WYRAPELL+G T
Sbjct: 156 RNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTT 215
Query: 178 YGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGI 237
+S+D+WA+GC+ AELL +PL PG S++ Q+ LI++ LG F
Sbjct: 216 QTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQY 275
Query: 238 SIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF 286
S+ + L+ KF + L + +P R T LESSYF
Sbjct: 276 SL-RKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF 323
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 185 bits (470), Expect = 4e-47
Identities = 113/324 (34%), Positives = 177/324 (54%), Gaps = 21/324 (6%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVE---SEDDPVVKKIALREIRMLKQ 57
M +Y + + G+G+YG V ++ SG++VA+K+ S D+ + LRE++ LK+
Sbjct: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECM----NLREVKSLKK 56
Query: 58 LKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFC 117
L H N++ L EV R ++ +FEY L ++ + VI+++++Q LQ L F
Sbjct: 57 LNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFI 116
Query: 118 HIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQ 177
H H HRD+KPEN+L ++KI DFG A+ L YTDYV+TRWYRAPE+L+ +
Sbjct: 117 HKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSV 176
Query: 178 YGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG----KLIPRHQSIFKSNGF 233
Y S +D+WA+G + AEL +PL+PG S+VD+++ I + LG P + S F
Sbjct: 177 YSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNF 236
Query: 234 FHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQ 293
+ P +++TL S+ A+ M L +P R T SQ L+ Y FQ Q
Sbjct: 237 RFPQCV--PINLKTLIPNASN---EAIQLMTEMLNWDPKKRPTASQALKHPY---FQVGQ 288
Query: 294 IKRKARN--EGRNRRRQQVLPLKS 315
+ + N E + +Q+ PL+S
Sbjct: 289 VLGPSSNHLESKQSLNKQLQPLES 312
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 184 bits (468), Expect = 7e-47
Identities = 107/306 (34%), Positives = 173/306 (56%), Gaps = 23/306 (7%)
Query: 2 EKYEKLAKTGEGSYGVVFKCRN-KTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK- 59
++YE +A+ GEG+YG VFK R+ K G+ VA+K+ + + +RE+ +L+ L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 60 --HPNLVNLIEVFR-----RKRKMHLVFEYCDHTLLNELERNPN-GVADGVIKSVLWQTL 111
HPN+V L +V R+ K+ LVFE+ D L L++ P GV IK +++Q L
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 112 QALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPEL 171
+ L+F H H +HRD+KP+NIL+T G IK+ DFG A+I A T V T WYRAPE+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190
Query: 172 LVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSN 231
L+ + Y + VD+W++GC+FAE+ +PL+ G SDVDQL I+ +G +P +
Sbjct: 191 LL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEED----- 242
Query: 232 GFFHGISIP----EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFD 287
+ +++P + + +E+ +D+ + + + CL NP R++ L YF
Sbjct: 243 -WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301
Query: 288 SFQEAQ 293
+ +
Sbjct: 302 DLERCK 307
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 184 bits (468), Expect = 7e-47
Identities = 107/306 (34%), Positives = 173/306 (56%), Gaps = 23/306 (7%)
Query: 2 EKYEKLAKTGEGSYGVVFKCRN-KTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK- 59
++YE +A+ GEG+YG VFK R+ K G+ VA+K+ + + +RE+ +L+ L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 60 --HPNLVNLIEVFR-----RKRKMHLVFEYCDHTLLNELERNPN-GVADGVIKSVLWQTL 111
HPN+V L +V R+ K+ LVFE+ D L L++ P GV IK +++Q L
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 112 QALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPEL 171
+ L+F H H +HRD+KP+NIL+T G IK+ DFG A+I A T V T WYRAPE+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEV 190
Query: 172 LVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSN 231
L+ + Y + VD+W++GC+FAE+ +PL+ G SDVDQL I+ +G +P +
Sbjct: 191 LL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEED----- 242
Query: 232 GFFHGISIP----EPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFD 287
+ +++P + + +E+ +D+ + + + CL NP R++ L YF
Sbjct: 243 -WPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301
Query: 288 SFQEAQ 293
+ +
Sbjct: 302 DLERCK 307
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 182 bits (463), Expect = 3e-46
Identities = 114/342 (33%), Positives = 187/342 (54%), Gaps = 38/342 (11%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQL-K 59
+ +Y + G+G+YG+V+K ++ +G+VVA+KK ++ D + REI +L++
Sbjct: 10 VRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGD 69
Query: 60 HPNLVNLIEVFRRK--RKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFC 117
HPN+++L++V R + R ++LVFE+ D T LN + R + D ++S+ +Q L+A F
Sbjct: 70 HPNIISLLDVIRAENDRDIYLVFEFMD-TDLNAVIRKGGLLQDVHVRSIFYQLLRATRFL 128
Query: 118 HIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGD--------AYTDYVATRWYRAP 169
H + +HRD KP N+L+ +K+CDFG A+ L GD A T+YVATRWYRAP
Sbjct: 129 HSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSL--GDLPEGPEDQAVTEYVATRWYRAP 186
Query: 170 ELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFK 229
E+L+ +Y VD+W++GC+ E+L G+PL+PG S + QL LI+ T+ P + +
Sbjct: 187 EVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPP--PSEEDLLA 244
Query: 230 SN-----GFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESS 284
H + + ++ L D P AL+ ++ L PD RL+ +Q L+
Sbjct: 245 LGSGCRASVLHQLGSRPRQTLDALLP--PDTSPEALDLLRRLLVFAPDKRLSATQALQHP 302
Query: 285 YFDSF--------QEAQIKRKARN-------EGRNRRRQQVL 311
Y F +EA ++ +A E R+R Q +L
Sbjct: 303 YVQRFHCPSDEWAREADVRPRAHEGVQLSVPEYRSRVYQMIL 344
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 182 bits (462), Expect = 3e-46
Identities = 102/297 (34%), Positives = 167/297 (56%), Gaps = 13/297 (4%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
++K++ + GEG+YG V+K ++K +G++VA+KK + A+REI++L+QL H
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 61 PNLVNLIEVFRRKRK----------MHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQT 110
++VN+ E+ K+ +LVFEY DH L+ LE ++ IKS + Q
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 111 LQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDA--YTDYVATRWYRA 168
++ L +CH N +HRDIK NIL+ G IK+ DFG A++ ++ YT+ V T WYR
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903
Query: 169 PELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIF 228
PELL+G+ +Y ++D+W+ GC+ EL T +P++ ++ QL LI R G P
Sbjct: 904 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963
Query: 229 KSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSY 285
+F+ + P+ + L E+FS + AL+ + L ++P R T Q L+S +
Sbjct: 964 IKLPYFNTMK-PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDF 1019
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 182 bits (462), Expect = 3e-46
Identities = 102/297 (34%), Positives = 167/297 (56%), Gaps = 13/297 (4%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
++K++ + GEG+YG V+K ++K +G++VA+KK + A+REI++L+QL H
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 61 PNLVNLIEVFRRKRK----------MHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQT 110
++VN+ E+ K+ +LVFEY DH L+ LE ++ IKS + Q
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 111 LQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDA--YTDYVATRWYRA 168
++ L +CH N +HRDIK NIL+ G IK+ DFG A++ ++ YT+ V T WYR
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903
Query: 169 PELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIF 228
PELL+G+ +Y ++D+W+ GC+ EL T +P++ ++ QL LI R G P
Sbjct: 904 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963
Query: 229 KSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSY 285
+F+ + P+ + L E+FS + AL+ + L ++P R T Q L+S +
Sbjct: 964 IKLPYFNTMK-PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDF 1019
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 182 bits (461), Expect = 4e-46
Identities = 91/242 (37%), Positives = 147/242 (60%), Gaps = 2/242 (0%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
ME Y KL K GEG+Y V+K R+K + +VA+K+ + E + A+RE+ +LK LKH
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKDLKH 247
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L ++ + + LVFEY D L ++ N ++ +K L+Q L+ L +CH
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRR 307
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQI-LIPGDAYTDYVATRWYRAPELLVGDTQYG 179
+HRD+KP+N+LI ++G +K+ DFG A+ +P Y++ V T WYR P++L+G ++Y
Sbjct: 308 KVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
+ +D+W +GC+F E+ +G+PL+PG + D+L+LI R LG SN F +
Sbjct: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
Query: 240 PE 241
P+
Sbjct: 428 PK 429
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 181 bits (460), Expect = 6e-46
Identities = 102/300 (34%), Positives = 161/300 (53%), Gaps = 14/300 (4%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
+ KYEKLAK G+G++G VFK R++ +GQ VA+KK + + ALREI++L+ LKH
Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
Query: 61 PNLVNLIEVFRRKR--------KMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQ 112
N+VNLIE+ R K ++LVF++C+H L L IK V+ L
Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135
Query: 113 ALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQIL-----IPGDAYTDYVATRWYR 167
L + H + +HRD+K N+LIT+ G++K+ DFG A+ + YT+ V T WYR
Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195
Query: 168 APELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSI 227
PELL+G+ YG +D+W GC+ AE+ T P+ G ++ QL LI + G + P
Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255
Query: 228 FKSNGFFHGISIPEPEDMETLEEKFSDVH-PVALNFMKGCLKMNPDDRLTCSQLLESSYF 286
+ + + + + + + + + V P AL+ + L ++P R+ L +F
Sbjct: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 181 bits (459), Expect = 7e-46
Identities = 88/219 (40%), Positives = 139/219 (63%), Gaps = 2/219 (0%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
+E Y KL K GEG+Y V+K ++K + +VA+K+ + E + A+RE+ +LK LKH
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKE-IRLEHEEGAPCTAIREVSLLKDLKH 226
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L ++ ++ + LVFEY D L L+ N + +K L+Q L+ L +CH
Sbjct: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 286
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQI-LIPGDAYTDYVATRWYRAPELLVGDTQYG 179
+HRD+KP+N+LI ++G +K+ DFG A+ IP Y++ V T WYR P++L+G T Y
Sbjct: 287 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 346
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218
+ +D+W +GC+F E+ TG+PL+PG + +QL+ I R LG
Sbjct: 347 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILG 385
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 181 bits (459), Expect = 7e-46
Identities = 88/219 (40%), Positives = 139/219 (63%), Gaps = 2/219 (0%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
+E Y KL K GEG+Y V+K ++K + +VA+K+ + E + A+RE+ +LK LKH
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKE-IRLEHEEGAPCTAIREVSLLKDLKH 220
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L ++ ++ + LVFEY D L L+ N + +K L+Q L+ L +CH
Sbjct: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 280
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQI-LIPGDAYTDYVATRWYRAPELLVGDTQYG 179
+HRD+KP+N+LI ++G +K+ DFG A+ IP Y++ V T WYR P++L+G T Y
Sbjct: 281 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 340
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG 218
+ +D+W +GC+F E+ TG+PL+PG + +QL+ I R LG
Sbjct: 341 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILG 379
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 181 bits (459), Expect = 7e-46
Identities = 100/296 (33%), Positives = 164/296 (55%), Gaps = 11/296 (3%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
+E Y KL K GEG+Y VFK R+K + +VA+K+ + E + A+RE+ +LK LKH
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKH 229
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L ++ R + LVFEY D L L+ N ++ +K ++Q L+ L +CH
Sbjct: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 289
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQI-LIPGDAYTDYVATRWYRAPELLVGDTQYG 179
+HRD+KP+N+LI ++G +K+ DFG A+ +P Y++ V T WYR P++L+G T+Y
Sbjct: 290 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 349
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG----KLIPRHQSIFKSNGFFH 235
+ +D+W +GC+ E+ TG+PL+PG + ++L+LI R LG + P + + +
Sbjct: 350 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSF 409
Query: 236 GISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQE 291
+P+P L + ++ + L R++ L SYF S E
Sbjct: 410 PCYLPQP-----LINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGE 460
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 181 bits (459), Expect = 7e-46
Identities = 100/296 (33%), Positives = 164/296 (55%), Gaps = 11/296 (3%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
+E Y KL K GEG+Y VFK R+K + +VA+K+ + E + A+RE+ +LK LKH
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKH 199
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L ++ R + LVFEY D L L+ N ++ +K ++Q L+ L +CH
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQI-LIPGDAYTDYVATRWYRAPELLVGDTQYG 179
+HRD+KP+N+LI ++G +K+ DFG A+ +P Y++ V T WYR P++L+G T+Y
Sbjct: 260 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 319
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG----KLIPRHQSIFKSNGFFH 235
+ +D+W +GC+ E+ TG+PL+PG + ++L+LI R LG + P + + +
Sbjct: 320 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSF 379
Query: 236 GISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQE 291
+P+P L + ++ + L R++ L SYF S E
Sbjct: 380 PCYLPQP-----LINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGE 430
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 181 bits (459), Expect = 7e-46
Identities = 100/296 (33%), Positives = 164/296 (55%), Gaps = 11/296 (3%)
Query: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
+E Y KL K GEG+Y VFK R+K + +VA+K+ + E + A+RE+ +LK LKH
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKH 199
Query: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
N+V L ++ R + LVFEY D L L+ N ++ +K ++Q L+ L +CH
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 121 NCIHRDIKPENILITKQGIIKICDFGFAQI-LIPGDAYTDYVATRWYRAPELLVGDTQYG 179
+HRD+KP+N+LI ++G +K+ DFG A+ +P Y++ V T WYR P++L+G T+Y
Sbjct: 260 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 319
Query: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG----KLIPRHQSIFKSNGFFH 235
+ +D+W +GC+ E+ TG+PL+PG + ++L+LI R LG + P + + +
Sbjct: 320 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSF 379
Query: 236 GISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQE 291
+P+P L + ++ + L R++ L SYF S E
Sbjct: 380 PCYLPQP-----LINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGE 430
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,042,903
Number of Sequences: 37866
Number of extensions: 526017
Number of successful extensions: 3282
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 1050
Number of HSP's gapped (non-prelim): 920
length of query: 315
length of database: 18,247,518
effective HSP length: 102
effective length of query: 213
effective length of database: 14,385,186
effective search space: 3064044618
effective search space used: 3064044618
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.