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Search of human proteins with 57163987
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
(921 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 1850 0.0
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 1305 0.0
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 1302 0.0
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 1294 0.0
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 1276 0.0
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 1216 0.0
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 1212 0.0
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 1211 0.0
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 1207 0.0
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 500 e-141
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 490 e-138
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 76 2e-13
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens] 70 7e-12
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 66 1e-10
gi|108773804 Fraser syndrome 1 [Homo sapiens] 65 3e-10
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 64 6e-10
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 64 8e-10
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 64 8e-10
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 64 8e-10
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 60 1e-08
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 60 1e-08
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 60 1e-08
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 59 2e-08
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 55 3e-07
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens] 45 2e-04
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens] 45 2e-04
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens] 45 2e-04
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 37 0.084
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 37 0.084
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 36 0.19
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 1850 bits (4793), Expect = 0.0
Identities = 921/921 (100%), Positives = 921/921 (100%)
Query: 1 MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP 60
MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP
Sbjct: 1 MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEP 60
Query: 61 DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT 120
DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT
Sbjct: 61 DDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITSKEKEITITKANGETSVGT 120
Query: 121 VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC 180
VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC
Sbjct: 121 VRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC 180
Query: 181 IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV 240
IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV
Sbjct: 181 IYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCV 240
Query: 241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP 300
VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP
Sbjct: 241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGAEAPGELGGLGP 300
Query: 301 GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL 360
GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL
Sbjct: 301 GPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYYALLHQQKSRAFYRIQATRL 360
Query: 361 MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG 420
MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG
Sbjct: 361 MTGAGNVLRRHAADASRRAAPAEGAGEDEDDGASRIFFEPSLYHCLENCGSVLLSVTCQG 420
Query: 421 GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV 480
GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV
Sbjct: 421 GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV 480
Query: 481 RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT 540
RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT
Sbjct: 481 RLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGT 540
Query: 541 VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE 600
VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE
Sbjct: 541 VDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE 600
Query: 601 YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE 660
YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE
Sbjct: 601 YEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLE 660
Query: 661 VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS 720
VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS
Sbjct: 661 VIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPS 720
Query: 721 CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK 780
CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK
Sbjct: 721 CFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLK 780
Query: 781 DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY 840
DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY
Sbjct: 781 DSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVY 840
Query: 841 WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL 900
WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL
Sbjct: 841 WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFL 900
Query: 901 GLWLLYILFASLEAYCHIRGF 921
GLWLLYILFASLEAYCHIRGF
Sbjct: 901 GLWLLYILFASLEAYCHIRGF 921
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 1305 bits (3377), Expect = 0.0
Identities = 639/891 (71%), Positives = 763/891 (85%), Gaps = 23/891 (2%)
Query: 43 CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102
C GS C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 48 CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
Query: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162
+E+E+TI K NGETS T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
Query: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222
TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
Query: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282
VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD GIII EGD PK IE+
Sbjct: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
Query: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341
DG + + G L P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
Query: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400
AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+ DE +D S++FF+P
Sbjct: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
Query: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460
Y CLENCG+VLL+V +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
Query: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511
E +GIIDDDIFEEDEHFFVRL N+R+ + Q P+ G P+ L +P +
Sbjct: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
Query: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571
ATVTILDDDHAGIF+F+ +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG
Sbjct: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
Query: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDG 631
+ED GELEF +DET+KT++VKIVD+EEYE+++NFFI LG+P+W++RGISALLL+
Sbjct: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVT 638
Query: 632 DRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSW 691
DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHSW
Sbjct: 639 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 698
Query: 692 REQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750
R+QF+EAITVS AGDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA
Sbjct: 699 RDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 756
Query: 751 CFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQC 810
CF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD
Sbjct: 757 CFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVY 816
Query: 811 ADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGI 870
ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV I
Sbjct: 817 ADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 876
Query: 871 AVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 877 SVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 927
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 1302 bits (3369), Expect = 0.0
Identities = 639/891 (71%), Positives = 763/891 (85%), Gaps = 26/891 (2%)
Query: 43 CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102
C GS C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 48 CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
Query: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162
+E+E+TI K NGETS T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
Query: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222
TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
Query: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282
VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD GIII EGD PK IE+
Sbjct: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
Query: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341
DG + + G L P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
Query: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400
AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+ DE +D S++FF+P
Sbjct: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
Query: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460
Y CLENCG+VLL+V +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
Query: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511
E +GIIDDDIFEEDEHFFVRL N+R+ + Q P+ G P+ L +P +
Sbjct: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
Query: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571
ATVTILDDDHAGIF+F+ +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG
Sbjct: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
Query: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDG 631
+ED GELEF +DET+KT++VKIVD+EEYE+++NFFI LG+P+W++RGISALLL+
Sbjct: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSP--- 635
Query: 632 DRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSW 691
DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHSW
Sbjct: 636 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 695
Query: 692 REQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750
R+QF+EAITVS AGDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA
Sbjct: 696 RDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 753
Query: 751 CFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQC 810
CF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD
Sbjct: 754 CFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVY 813
Query: 811 ADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGI 870
ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV I
Sbjct: 814 ADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 873
Query: 871 AVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 874 SVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 924
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 1294 bits (3348), Expect = 0.0
Identities = 635/891 (71%), Positives = 759/891 (85%), Gaps = 29/891 (3%)
Query: 43 CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102
C GS C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 48 CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
Query: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162
+E+E+TI K NGETS T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
Query: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222
TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
Query: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282
VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD GIII EGD PK IE+
Sbjct: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
Query: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341
DG + + G L P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
Query: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400
AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+ DE +D S++FF+P
Sbjct: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
Query: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460
Y CLENCG+VLL+V +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
Query: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511
E +GIIDDDIFEEDEHFFVRL N+R+ + Q P+ G P+ L +P +
Sbjct: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
Query: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571
ATVTILDDDHAGIF+F+ +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG
Sbjct: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
Query: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDG 631
+ED GELEF +DET+KT++VKIVD+EEYE+++NFFI LG+P+W++RGIS +
Sbjct: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDVT------ 632
Query: 632 DRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSW 691
DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHSW
Sbjct: 633 DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSW 692
Query: 692 REQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750
R+QF+EAITVS AGDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA
Sbjct: 693 RDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWA 750
Query: 751 CFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQC 810
CF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD
Sbjct: 751 CFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVY 810
Query: 811 ADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGI 870
ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV I
Sbjct: 811 ADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 870
Query: 871 AVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 871 SVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 1276 bits (3303), Expect = 0.0
Identities = 630/892 (70%), Positives = 752/892 (84%), Gaps = 27/892 (3%)
Query: 43 CQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEVITS 102
C GS C+ GV+LP+W P++PSLGDK AR +VYFVA++YMFLGVSIIADRFMA+IEVITS
Sbjct: 48 CSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITS 107
Query: 103 KEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGP 162
+E+E+TI K NGETS T+R+WNETVSNLTLMALGSSAPEILLS+IEVCGH F AG+LGP
Sbjct: 108 QEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGP 167
Query: 163 GTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPG 222
TIVGSAAFNMF++I +C+YVIP GE+RKIKHLRVFF+TA+WSIFAY+WLY+ILAVFSPG
Sbjct: 168 STIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPG 227
Query: 223 VVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIEL 282
VVQVWE LLTL FFPVCV+ AW+ADKRLLFYKY++K+YRTD GIII EGD PK IE+
Sbjct: 228 VVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEM 287
Query: 283 DGTFVGAE-APGELGGLGPGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIANYY 341
DG + + G L P E +E+D SRRE+I+ILKDLKQKHP+KDL+QLV +ANYY
Sbjct: 288 DGKMMNSHFLDGNL-----VPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342
Query: 342 ALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGEDE-DDGASRIFFEP 400
AL HQQKSRAFYRIQATR+MTGAGN+L++HAA+ +++A+ DE +D S++FF+P
Sbjct: 343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDP 402
Query: 401 SLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQK 460
Y CLENCG+VLL+V +GG+ + T YVDY+TEDGSA AG+DYE++EGT+V KPGETQK
Sbjct: 403 CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQK 462
Query: 461 ELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG---------GRPKGRLVAPLL 511
E +GIIDDDIFEEDEHFFVRL N+R+ + Q P+ G P+ L +P +
Sbjct: 463 EFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQ----PEEGMPPAIFNSLPLPRAVLASPCV 518
Query: 512 ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGV 571
ATVTILDDDHAGIF+F+ +HVSE +G ++V+V+R+SGARGTV +P+RTV+GTA+GGG
Sbjct: 519 ATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGE 578
Query: 572 HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGI-SALLLNQGD 630
+ED GELEF +DET+KT+ +K++DDE YEK N+FIE+ P+ + ALLL+
Sbjct: 579 DFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSP-- 636
Query: 631 GDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHS 690
DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHS
Sbjct: 637 -DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHS 695
Query: 691 WREQFLEAITVS-AGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW 749
WR+QF+EAITVS AGDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW
Sbjct: 696 WRDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGW 753
Query: 750 ACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQ 809
ACF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD
Sbjct: 754 ACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDV 813
Query: 810 CADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVG 869
ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV
Sbjct: 814 YADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVC 873
Query: 870 IAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
I+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 874 ISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 925
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 1216 bits (3146), Expect = 0.0
Identities = 605/894 (67%), Positives = 731/894 (81%), Gaps = 14/894 (1%)
Query: 40 TGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEV 99
TG C GSY C+ GV+LP+WEP DPS GDK ARA VYFVAMVYMFLGVSIIADRFM++IEV
Sbjct: 46 TGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV 105
Query: 100 ITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGE 159
ITS+EKEITI K NGET+ TVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF AG+
Sbjct: 106 ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGD 165
Query: 160 LGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVF 219
LGP TIVGSAAFNMF++IA+C+YV+P GE+RKIKHLRVFFVTA+WSIFAY WLY+IL+V
Sbjct: 166 LGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVI 225
Query: 220 SPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS 279
SPGVV+VWE LLT FFP+CVVFAW+AD+RLLFYKYVYKRYR + G+II EGD P S
Sbjct: 226 SPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSS 285
Query: 280 ---IELDGTFVGAEAPGELGGLGPGPAEARELD--ASRREVIQILKDLKQKHPDKDLEQL 334
IE+DG V + L G + R+ D +RRE+ +ILK+LKQKHPDK++EQL
Sbjct: 286 KTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQL 345
Query: 335 VGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDG 392
+ +ANY L QQKSRAFYRIQATRLMTGAGN+L+RHAAD +R+A + E+D
Sbjct: 346 IELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDP 405
Query: 393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLV 452
S+IFFE Y CLENCG+V L++ +GG+ +T +VD+RTEDG+A AGSDYE++EGT+V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV---GDAQGMFEPDGGGRPKGRLVAP 509
FKPG+TQKE+R+GIIDDDIFEEDE+F V L N++V G+ E + L +P
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS-TLACLGSP 524
Query: 510 LLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG 569
ATVTI DDDHAGIF+F++ + HVSE +G ++V+V+R+SGARG V +PY+T++GTARGG
Sbjct: 525 STATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG 584
Query: 570 GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISA--LLLN 627
G +ED CGELEF +DE +K + ++I D EEYEK+ +F + L +P+W++RG+ + +
Sbjct: 585 GEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITD 644
Query: 628 QGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIG 687
+ D + LT++EEE RRIAEMG+P+LGE+ +LEVIIEESY+FK+TVDKLIKKTNLALV+G
Sbjct: 645 EYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVG 704
Query: 688 THSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCH 747
T+SWREQF+EAITVSAG E++++D EE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +
Sbjct: 705 TNSWREQFIEAITVSAG-EDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWN 763
Query: 748 GWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQ 807
GWACF VSIL+IGLLTA IGDLASHFGCT+GLKDSV AVVFVALGTS+PDTFASKVAA Q
Sbjct: 764 GWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQ 823
Query: 808 DQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAF 867
DQ ADASIGNVTGSNAVNVFLG+GVAWS+AA+Y A G F+V GTLAFSVTLFT+FAF
Sbjct: 824 DQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAF 883
Query: 868 VGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
+ + VLLYRRRP IGGELGGPR KL T+ LF+ LWLLYI F+SLEAYCHI+GF
Sbjct: 884 INVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 937
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 1212 bits (3137), Expect = 0.0
Identities = 612/925 (66%), Positives = 734/925 (79%), Gaps = 45/925 (4%)
Query: 40 TGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEV 99
TG C GSY C+ GV+LP+WEP DPS GDK ARA VYFVAMVYMFLGVSIIADRFM++IEV
Sbjct: 46 TGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV 105
Query: 100 ITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGE 159
ITS+EKEITI K NGET+ TVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF AG+
Sbjct: 106 ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGD 165
Query: 160 LGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVF 219
LGP TIVGSAAFNMF++IA+C+YV+P GE+RKIKHLRVFFVTA+WSIFAY WLY+IL+V
Sbjct: 166 LGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVI 225
Query: 220 SPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS 279
SPGVV+VWE LLT FFP+CVVFAW+AD+RLLFYKYVYKRYR + G+II EGD P S
Sbjct: 226 SPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSS 285
Query: 280 ---IELDGTFVGAEAPGELGGLGPGPAEARELD--ASRREVIQILKDLKQKHPDKDLEQL 334
IE+DG V + L G + R+ D +RRE+ +ILK+LKQKHPDK++EQL
Sbjct: 286 KTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQL 345
Query: 335 VGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDG 392
+ +ANY L QQKSRAFYRIQATRLMTGAGN+L+RHAAD +R+A + E+D
Sbjct: 346 IELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDP 405
Query: 393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLV 452
S+IFFE Y CLENCG+V L++ +GG+ +T +VD+RTEDG+A AGSDYE++EGT+V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV---GDAQGMFEPDGGGRPKGRLVAP 509
FKPG+TQKE+R+GIIDDDIFEEDE+F V L N++V G+ E + L +P
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS-TLACLGSP 524
Query: 510 LLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG 569
ATVTI DDDHAGIF+F++ + HVSE +G ++V+V+R+SGARG V +PY+T++GTARGG
Sbjct: 525 STATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG 584
Query: 570 GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRG-ISALLLN- 627
G +ED CGELEF +DE +KT+ VK++DDEEYEK FF+E+G+P+ ++ ALLLN
Sbjct: 585 GEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNE 644
Query: 628 -------------------------------QGDGDRKLTAEEEEARRIAEMGKPVLGEN 656
+ D + LT++EEE RRIAEMG+P+LGE+
Sbjct: 645 LGGFTITGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEH 704
Query: 657 CRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREE 716
+LEVIIEESY+FK+TVDKLIKKTNLALV+GT+SWREQF+EAITVSAG E++++D EE
Sbjct: 705 TKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAG-EDDDDDECGEE 763
Query: 717 RLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCT 776
+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+IGLLTA IGDLASHFGCT
Sbjct: 764 KLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCT 823
Query: 777 VGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSV 836
+GLKDSV AVVFVALGTS+PDTFASKVAA QDQ ADASIGNVTGSNAVNVFLG+GVAWS+
Sbjct: 824 IGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSI 883
Query: 837 AAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATT 896
AA+Y A G F+V GTLAFSVTLFT+FAF+ + VLLYRRRP IGGELGGPR KL T+
Sbjct: 884 AAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTS 943
Query: 897 ALFLGLWLLYILFASLEAYCHIRGF 921
LF+ LWLLYI F+SLEAYCHI+GF
Sbjct: 944 CLFVLLWLLYIFFSSLEAYCHIKGF 968
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 1211 bits (3132), Expect = 0.0
Identities = 612/930 (65%), Positives = 734/930 (78%), Gaps = 50/930 (5%)
Query: 40 TGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEV 99
TG C GSY C+ GV+LP+WEP DPS GDK ARA VYFVAMVYMFLGVSIIADRFM++IEV
Sbjct: 46 TGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV 105
Query: 100 ITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGE 159
ITS+EKEITI K NGET+ TVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF AG+
Sbjct: 106 ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGD 165
Query: 160 LGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVF 219
LGP TIVGSAAFNMF++IA+C+YV+P GE+RKIKHLRVFFVTA+WSIFAY WLY+IL+V
Sbjct: 166 LGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVI 225
Query: 220 SPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS 279
SPGVV+VWE LLT FFP+CVVFAW+AD+RLLFYKYVYKRYR + G+II EGD P S
Sbjct: 226 SPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSS 285
Query: 280 ---IELDGTFVGAEAPGELGGLGPGPAEARELD--ASRREVIQILKDLKQKHPDKDLEQL 334
IE+DG V + L G + R+ D +RRE+ +ILK+LKQKHPDK++EQL
Sbjct: 286 KTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQL 345
Query: 335 VGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDG 392
+ +ANY L QQKSRAFYRIQATRLMTGAGN+L+RHAAD +R+A + E+D
Sbjct: 346 IELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDP 405
Query: 393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLV 452
S+IFFE Y CLENCG+V L++ +GG+ +T +VD+RTEDG+A AGSDYE++EGT+V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV---GDAQGMFEPDGGGRPKGRLVAP 509
FKPG+TQKE+R+GIIDDDIFEEDE+F V L N++V G+ E + L +P
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS-TLACLGSP 524
Query: 510 LLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG 569
ATVTI DDDHAGIF+F++ + HVSE +G ++V+V+R+SGARG V +PY+T++GTARGG
Sbjct: 525 STATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG 584
Query: 570 GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRG-ISALLLN- 627
G +ED CGELEF +DE +KT+ VK++DDEEYEK FF+E+G+P+ ++ ALLLN
Sbjct: 585 GEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNE 644
Query: 628 ------------------------------------QGDGDRKLTAEEEEARRIAEMGKP 651
+ D + LT++EEE RRIAEMG+P
Sbjct: 645 LGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRP 704
Query: 652 VLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEED 711
+LGE+ +LEVIIEESY+FK+TVDKLIKKTNLALV+GT+SWREQF+EAITVSAG E++++D
Sbjct: 705 ILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAG-EDDDDD 763
Query: 712 GSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLAS 771
EE+LPSCFDYVMHFLTVFWKVLFA VPPTEY +GWACF VSIL+IGLLTA IGDLAS
Sbjct: 764 ECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLAS 823
Query: 772 HFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLG 831
HFGCT+GLKDSV AVVFVALGTS+PDTFASKVAA QDQ ADASIGNVTGSNAVNVFLG+G
Sbjct: 824 HFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIG 883
Query: 832 VAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGP 891
VAWS+AA+Y A G F+V GTLAFSVTLFT+FAF+ + VLLYRRRP IGGELGGPR
Sbjct: 884 VAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTA 943
Query: 892 KLATTALFLGLWLLYILFASLEAYCHIRGF 921
KL T+ LF+ LWLLYI F+SLEAYCHI+GF
Sbjct: 944 KLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 973
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 1207 bits (3123), Expect = 0.0
Identities = 605/917 (65%), Positives = 731/917 (79%), Gaps = 37/917 (4%)
Query: 40 TGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMAAIEV 99
TG C GSY C+ GV+LP+WEP DPS GDK ARA VYFVAMVYMFLGVSIIADRFM++IEV
Sbjct: 46 TGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEV 105
Query: 100 ITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGE 159
ITS+EKEITI K NGET+ TVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF AG+
Sbjct: 106 ITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGD 165
Query: 160 LGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVF 219
LGP TIVGSAAFNMF++IA+C+YV+P GE+RKIKHLRVFFVTA+WSIFAY WLY+IL+V
Sbjct: 166 LGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVI 225
Query: 220 SPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS 279
SPGVV+VWE LLT FFP+CVVFAW+AD+RLLFYKYVYKRYR + G+II EGD P S
Sbjct: 226 SPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSS 285
Query: 280 ---IELDGTFVGAEAPGELGGLGPGPAEARELD--ASRREVIQILKDLKQKHPDKDLEQL 334
IE+DG V + L G + R+ D +RRE+ +ILK+LKQKHPDK++EQL
Sbjct: 286 KTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQL 345
Query: 335 VGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADASRRAAPAEGAGED--EDDG 392
+ +ANY L QQKSRAFYRIQATRLMTGAGN+L+RHAAD +R+A + E+D
Sbjct: 346 IELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDP 405
Query: 393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLV 452
S+IFFE Y CLENCG+V L++ +GG+ +T +VD+RTEDG+A AGSDYE++EGT+V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV---GDAQGMFEPDGGGRPKGRLVAP 509
FKPG+TQKE+R+GIIDDDIFEEDE+F V L N++V G+ E + L +P
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVS-TLACLGSP 524
Query: 510 LLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGG 569
ATVTI DDDHAGIF+F++ + HVSE +G ++V+V+R+SGARG V +PY+T++GTARGG
Sbjct: 525 STATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG 584
Query: 570 GVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISA------ 623
G +ED CGELEF +DE +K + ++I D EEYEK+ +F + L +P+W++RG+
Sbjct: 585 GEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITG 644
Query: 624 -------------------LLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIE 664
+ ++ D + LT++EEE RRIAEMG+P+LGE+ +LEVIIE
Sbjct: 645 QPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIE 704
Query: 665 ESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDY 724
ESY+FK+TVDKLIKKTNLALV+GT+SWREQF+EAITVSAG E++++D EE+LPSCFDY
Sbjct: 705 ESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAG-EDDDDDECGEEKLPSCFDY 763
Query: 725 VMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVN 784
VMHFLTVFWKVLFA VPPTEY +GWACF VSIL+IGLLTA IGDLASHFGCT+GLKDSV
Sbjct: 764 VMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVT 823
Query: 785 AVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQ 844
AVVFVALGTS+PDTFASKVAA QDQ ADASIGNVTGSNAVNVFLG+GVAWS+AA+Y A
Sbjct: 824 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAAN 883
Query: 845 GRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWL 904
G F+V GTLAFSVTLFT+FAF+ + VLLYRRRP IGGELGGPR KL T+ LF+ LWL
Sbjct: 884 GEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWL 943
Query: 905 LYILFASLEAYCHIRGF 921
LYI F+SLEAYCHI+GF
Sbjct: 944 LYIFFSSLEAYCHIKGF 960
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 500 bits (1288), Expect = e-141
Identities = 248/306 (81%), Positives = 277/306 (90%), Gaps = 9/306 (2%)
Query: 617 LKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKL 676
++RGIS + DRKLT EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKL
Sbjct: 1 MERGISDVT------DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKL 54
Query: 677 IKKTNLALVIGTHSWREQFLEAITVSA-GDEEEEEDGSREERLPSCFDYVMHFLTVFWKV 735
IKKTNLALV+GTHSWR+QF+EAITVSA GDE+E+E G EERLPSCFDYVMHFLTVFWKV
Sbjct: 55 IKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKV 112
Query: 736 LFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSI 795
LFACVPPTEYCHGWACF VSIL+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+
Sbjct: 113 LFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSV 172
Query: 796 PDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTL 855
PDTFASK AALQD ADASIGNVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTL
Sbjct: 173 PDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTL 232
Query: 856 AFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAY 915
AFSVTLFT+FAFV I+VLLYRRRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAY
Sbjct: 233 AFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAY 292
Query: 916 CHIRGF 921
C+I+GF
Sbjct: 293 CYIKGF 298
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 490 bits (1261), Expect = e-138
Identities = 239/285 (83%), Positives = 265/285 (92%), Gaps = 3/285 (1%)
Query: 638 EEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLE 697
EEEEA+RIAEMGKPVLGE+ +LEVIIEESY+FK TVDKLIKKTNLALV+GTHSWR+QF+E
Sbjct: 2 EEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFME 61
Query: 698 AITVSA-GDEEEEEDGSREERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFGVSI 756
AITVSA GDE+E+E G EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACF VSI
Sbjct: 62 AITVSAAGDEDEDESG--EERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSI 119
Query: 757 LVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIG 816
L+IG+LTA+IGDLASHFGCT+GLKDSV AVVFVA GTS+PDTFASK AALQD ADASIG
Sbjct: 120 LIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIG 179
Query: 817 NVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYR 876
NVTGSNAVNVFLG+G+AWSVAA+YWA+QG+ F V GTLAFSVTLFT+FAFV I+VLLYR
Sbjct: 180 NVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYR 239
Query: 877 RRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIRGF 921
RRPH+GGELGGPRG KLATT LF+ LWLLYILFA+LEAYC+I+GF
Sbjct: 240 RRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 284
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 75.9 bits (185), Expect = 2e-13
Identities = 69/225 (30%), Positives = 102/225 (45%), Gaps = 50/225 (22%)
Query: 25 TPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVV-YFVAMVYMF 83
TP P +S+ ST QG Y D SL ++ A++ + + M+YMF
Sbjct: 98 TPQPPLSKEGESENSTDHAQGDY-----------PKDIFSLEERRKGAIILHVIGMIYMF 146
Query: 84 LGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPE 142
+ ++I+ D F ++ VIT K +G ++ V+ T MA G SAPE
Sbjct: 147 IALAIVCDEFFVPSLTVITEK--------------LGI----SDDVAGATFMAAGGSAPE 188
Query: 143 ILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTA 202
+ S+I V +G GTIVGSA FN+ VI +C A SR+I +L
Sbjct: 189 LFTSLIGVF---IAHSNVGIGTIVGSAVFNILFVIGMC-----ALFSREILNL------T 234
Query: 203 SWSIFAYVWLYLI-----LAVFSPGVVQVWEALLTLVFFPVCVVF 242
W +F V Y++ + F V+ WE+LL L + VVF
Sbjct: 235 WWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVF 279
Score = 53.1 bits (126), Expect = 1e-06
Identities = 50/188 (26%), Positives = 80/188 (42%), Gaps = 8/188 (4%)
Query: 696 LEAITVSAGDEEEEEDGS----REERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWAC 751
+E DEEE++ S E R F V + W L P+
Sbjct: 443 IEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPIT 502
Query: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
F SI I + + L+ A G T+G+ + + + +A GTSIPD S + A +
Sbjct: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA-RKGLG 561
Query: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRT-GTLAFSVTLFTVFAFVGI 870
D ++ + GSN ++ +GL + W + V Q P V + G V LF + FV +
Sbjct: 562 DMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQ--PVAVSSNGLFCAIVLLFIMLLFVIL 619
Query: 871 AVLLYRRR 878
++ L + R
Sbjct: 620 SIALCKWR 627
>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
Length = 6306
Score = 70.5 bits (171), Expect = 7e-12
Identities = 68/218 (31%), Positives = 95/218 (43%), Gaps = 26/218 (11%)
Query: 413 LLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIF 472
LL + QG G T ++RT +A + DY+ GTL F+PGE K + I I D+ I
Sbjct: 1741 LLVIRAQGLLGRVT--AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIP 1798
Query: 473 EEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKG-------------RLVAPLLATVTILDD 519
E ++ F V LLNL G A+ +F DG G G L VTI
Sbjct: 1799 ELEKSFKVELLNLEGGVAE-LFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILVTIAAS 1857
Query: 520 DHA-GIFSFQDRLLHVS-----ECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHY 573
DHA G+F F L VS + TV + V+R G V L + +D G
Sbjct: 1858 DHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPDG---DL 1913
Query: 574 EDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
G + F +T + V+I+ DE+ E F + +
Sbjct: 1914 AFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
Score = 68.6 bits (166), Expect = 3e-11
Identities = 48/178 (26%), Positives = 82/178 (46%), Gaps = 6/178 (3%)
Query: 431 YRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDA 490
Y+T G+A+AG D+ + G L+F+ GE +K L + I+DDD E E F + + + +
Sbjct: 4302 YKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGR 4361
Query: 491 QGMFEPDGGG----RPKGRLVAPLLATVTILDDDHAGIFSFQDR--LLHVSECMGTVDVR 544
F G +P ++ + + +D+ GI F + V E +G + +
Sbjct: 4362 GYDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIP 4421
Query: 545 VVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYE 602
VVR G G V + + +A GGV Y + F + + + + I+DD E E
Sbjct: 4422 VVRLHGTYGYVTADFISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESE 4479
Score = 67.8 bits (164), Expect = 4e-11
Identities = 51/183 (27%), Positives = 86/183 (46%), Gaps = 30/183 (16%)
Query: 443 DYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
D ++ G + F+ G+T + + I+ D+ E D+ F V +L++
Sbjct: 1912 DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSVLSVS---------------- 1955
Query: 503 KGRLVAPLLATVTIL-DDDHAGIFSFQD--RLLHVSECMGTVDVRVVRSSGARGTVRLPY 559
G L A + AT+T+L DD GIF F + R + V E + + ++R G G V + Y
Sbjct: 1956 SGSLGAHINATLTVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSY 2015
Query: 560 RTVDGTAR-----------GGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFF 608
T+D + G Y A G FG +++ T+ + I+DD+E E+ ++ F
Sbjct: 2016 ATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVF 2075
Query: 609 IEL 611
IEL
Sbjct: 2076 IEL 2078
Score = 66.6 bits (161), Expect = 1e-10
Identities = 62/228 (27%), Positives = 105/228 (46%), Gaps = 24/228 (10%)
Query: 390 DDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEG 449
DD + + EN +++VT GG + V ++ +A AG DY +
Sbjct: 2114 DDAFGTLQLSAPIVRVAENHVGPIINVTRTGG-AFADVSVKFKAVPITAIAGEDYSIASS 2172
Query: 450 TLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAP 509
+V GET K + I +I+D E +E F V+L+N E GG R +
Sbjct: 2173 DVVLLEGETSKAVPIYVINDIYPELEESFLVQLMN----------ETTGGAR-----LGA 2217
Query: 510 LLATVTILD--DDHAGIFSFQDRLLHVSE---CMGTVDVRVVRSSGARGTVRLPY-RTVD 563
L V I++ DD G+F FQ L V E V++ ++R+SG G V + + T++
Sbjct: 2218 LTEAVIIIEASDDPYGLFGFQITKLIVEEPEFNSVKVNLPIIRNSGTLGNVTVQWVATIN 2277
Query: 564 GTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
G G + G + F ET++TL ++++ D+ E ++ ++L
Sbjct: 2278 GQLATGDLRV--VSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQL 2323
Score = 65.5 bits (158), Expect = 2e-10
Identities = 65/226 (28%), Positives = 98/226 (43%), Gaps = 30/226 (13%)
Query: 427 FYVDYRTE-DGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNL 485
FY + E DG D+ + GT+ F P + + L I ++DDDI E +E+F V L++
Sbjct: 1609 FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA 1668
Query: 486 RVGDAQGMFEPDGGGRPKGRLVAPLLAT--VTILDDDHA-GIFSFQDRL----------- 531
GD + P G + P T +TI DH G+ F L
Sbjct: 1669 IPGDGKLGSTPTSGAS-----IDPEKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLP 1723
Query: 532 ------LHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDD 585
+ V E G + + V+R+ G G V +RTV TA Y++ G LEF
Sbjct: 1724 ASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPG 1782
Query: 586 ETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDG 631
E K + + I D+ E + +F +EL L+ G++ L G G
Sbjct: 1783 ERYKYIFINITDNSIPELEKSFKVELLN---LEGGVAELFRVDGSG 1825
Score = 65.1 bits (157), Expect = 3e-10
Identities = 53/188 (28%), Positives = 88/188 (46%), Gaps = 17/188 (9%)
Query: 443 DYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
++ + G L + ++ + I ++DDI EE + +L + G G+
Sbjct: 4200 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEG---GVLSESSS--- 4253
Query: 503 KGRLVAPLLATVTILDDDHA-GIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRT 561
A +T++ D G F+F L VSE V++ ++RSSG G VRL Y+T
Sbjct: 4254 --------TANITVVASDSPYGRFAFSHEQLRVSEAQ-RVNITIIRSSGDFGHVRLWYKT 4304
Query: 562 VDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGI 621
+ GTA G+ + A GEL F E K+L V+I+DD+ E + F + + + + RG
Sbjct: 4305 MSGTAE-AGLDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGY 4363
Query: 622 SALLLNQG 629
+ G
Sbjct: 4364 DFTIQENG 4371
Score = 63.9 bits (154), Expect = 6e-10
Identities = 52/176 (29%), Positives = 84/176 (47%), Gaps = 26/176 (14%)
Query: 443 DYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
D++ S G L F + + I IIDD FE E F + L+++ G
Sbjct: 3966 DFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGG-------------- 4011
Query: 503 KGRLVAPLLATVTILDDDHA-GIFSFQDRLLHVSECMGTVD------VRVVRSSGARGTV 555
GRL ++ TV I +D G+F F+++ + + E + + D + VVRS G +GTV
Sbjct: 4012 -GRLGDDVVVTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTV 4070
Query: 556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
RL + T+D A+ + G L F + E+ KT+ + + D E+ F I+L
Sbjct: 4071 RLEW-TIDEKAKH---NLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQL 4122
Score = 59.3 bits (142), Expect = 2e-08
Identities = 47/176 (26%), Positives = 81/176 (46%), Gaps = 6/176 (3%)
Query: 438 AKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLN-LRVGDAQGMFEP 496
A G DY + G +F +++ + I I+DDD E E F+ LLN V Q P
Sbjct: 2034 ATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIP 2093
Query: 497 DGGGRPK-GRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
+ P+ G V + + I +DD G ++ V+E + V R+ GA V
Sbjct: 2094 NS---PRLGPKVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADV 2150
Query: 556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
+ ++ V TA G Y A ++ + ET K + + +++D E +++F ++L
Sbjct: 2151 SVKFKAVPITAI-AGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2205
Score = 58.5 bits (140), Expect = 3e-08
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 26/191 (13%)
Query: 435 DGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMF 494
D A DY E ++ K + + I+ DD+ E +E F V + + + ++
Sbjct: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDF-- 3884
Query: 495 EPDGGGRPKGRLVAPLLATVTILD-DDHAGIFSFQDRLLHVSECMGTV------------ 541
G+P R +A + I + DD GIF F HV+ G V
Sbjct: 3885 ---STGQPSVRRPGMEIAEIMIEENDDPRGIFMF-----HVTRGAGEVITAYEVPPPLNV 3936
Query: 542 -DVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEE 600
V VVR +G+ G V + ++ +A G ++ + G LEF D + +++ I+DD E
Sbjct: 3937 LQVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAE 3994
Query: 601 YEKKDNFFIEL 611
+E + F I L
Sbjct: 3995 FELTETFNISL 4005
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/187 (27%), Positives = 86/187 (45%), Gaps = 23/187 (12%)
Query: 429 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVG 488
V++R G+A G D+ + L F GET+K + + I+DD E+DE V L+
Sbjct: 2622 VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSEPEDDESIIVSLV----- 2676
Query: 489 DAQGMFEPDGGGRPKGRLVAPLLATVTI---LDDDHAGIFSFQDRLLHVSECMGTV-DVR 544
+GG R + P TV + +D+ AGI SFQ V G +
Sbjct: 2677 ------YTEGGSR-----ILPSSDTVRVNILANDNVAGIVSFQTASRSVIGHEGEILQFH 2725
Query: 545 VVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKK 604
V+R+ RG V + ++ + +++ + G+L F + TL V ++DD E+K
Sbjct: 2726 VIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEGSLNTTLFVHLLDDNIPEEK 2782
Query: 605 DNFFIEL 611
+ + + L
Sbjct: 2783 EVYQVIL 2789
Score = 52.4 bits (124), Expect = 2e-06
Identities = 57/238 (23%), Positives = 99/238 (41%), Gaps = 27/238 (11%)
Query: 388 DEDDGASRIF-FEPSLYHCLENCGSV-LLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYE 445
D +DGA + ++ S + E GS+ L++ + G+ + +V ++ A+ G DY
Sbjct: 2953 DANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFV--YAQNLEAQVGLDYI 3010
Query: 446 YSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGR 505
++ L F GE K + I I+DDDI E DE F + L N G G+
Sbjct: 3011 FTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTN------------PSPGLELGK 3058
Query: 506 LVAPLLATVTILDDDHAGIFSF---------QDRLLHVSECMGTVDVRVVRSSGARGTVR 556
L+ + + +DD G+ SF + L+V E + + + + G GTV
Sbjct: 3059 NTIALI--IVLANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVT 3116
Query: 557 LPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP 614
+ + + + + G + + K LQ+ + D E E + F L P
Sbjct: 3117 VQFIVTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
Score = 50.8 bits (120), Expect = 6e-06
Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 10/168 (5%)
Query: 449 GTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVA 508
G L+ + GET + I I++DD+ E +E+F V L + + A P RL +
Sbjct: 2891 GFLILEEGETAAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPP-------RLDS 2943
Query: 509 PLLATVTILD--DDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTA 566
L I+D D G+ +Q V+E G++ + RS G V L +
Sbjct: 2944 EGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLE 3002
Query: 567 RGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP 614
G+ Y L F D E K + + I+DD+ E + F + L P
Sbjct: 3003 AQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
Score = 50.8 bits (120), Expect = 6e-06
Identities = 46/175 (26%), Positives = 76/175 (43%), Gaps = 25/175 (14%)
Query: 442 SDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGR 501
SD+ S G L+F+PGE + + + I+DD + E++E F V+L N + G G+ +
Sbjct: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDS----- 3639
Query: 502 PKGRLVAPLLATVTILDDDHA-GIFSFQDRLLHVS----ECMGTVDVRVVRSSGARGTVR 556
T+TIL +D A GI +F L+ E V + V R G G +
Sbjct: 3640 ----------VTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGRI- 3688
Query: 557 LPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
T+ A G G + F + + + T+ + I+ D E + + L
Sbjct: 3689 ----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739
Score = 49.3 bits (116), Expect = 2e-05
Identities = 61/221 (27%), Positives = 95/221 (42%), Gaps = 25/221 (11%)
Query: 397 FFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGS----DYEYSEGTLV 452
F EP + E G + G + T V Y T+DG A A E E TL+
Sbjct: 1006 FAEPRVVRVQE--GETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGE-TLI 1062
Query: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLA 512
F+ G Q+ + I + +D I E DE F++ LLN GD + +A
Sbjct: 1063 FEVGSRQQSISIFVNEDGIPETDEPFYIILLN-STGDTV--------------VYQYGVA 1107
Query: 513 TVTI-LDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTV-DGTARGGG 570
TV I +DD GIFS + V E T ++R G G+V + ++ + +A G
Sbjct: 1108 TVIIEANDDPNGIFSLEPIDKAVEEGK-TNAFWILRHRGYFGSVSVSWQLFQNDSALQPG 1166
Query: 571 VHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
+ + G + F D E K + + D+ E + +F++L
Sbjct: 1167 QEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFNEFYFLKL 1207
Score = 47.0 bits (110), Expect = 8e-05
Identities = 37/110 (33%), Positives = 61/110 (55%), Gaps = 7/110 (6%)
Query: 429 VDYRTEDGSAKAGSDYE-YSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV 487
V Y+T GSAK D+E G L F+ +T+ + I II+D + E +E F++ L ++ +
Sbjct: 5040 VSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEI 5099
Query: 488 GDAQGMFEPDGGGRPKGRLVAPLLATVTILD-DDHAGI-FSFQDRLLHVS 535
+G+ + D P+ L +A +TILD DD AG+ SF + + V+
Sbjct: 5100 ---RGLQKFDVNWSPRLNLDFS-VAVITILDNDDLAGMDISFPETTVAVA 5145
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/197 (26%), Positives = 78/197 (39%), Gaps = 24/197 (12%)
Query: 420 GGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFF 479
G N T V ED D+ + GET + + I + DDD+ E DE F
Sbjct: 59 GEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFI 113
Query: 480 VRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHA-GIFSFQD-RLLHVSEC 537
L + +P +L P TVTIL +D+A GI SF + VSE
Sbjct: 114 FHLT---------LQKPSA----NVKLGWPRTVTVTILSNDNAFGIISFNMLPSIAVSEP 160
Query: 538 MG---TVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVK 594
G ++ + ++R G G V + + V+G G + F +
Sbjct: 161 KGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNITFPPGRATVIYNLT 219
Query: 595 IVDDEEYEKKDNFFIEL 611
++DDE E + F I+L
Sbjct: 220 VLDDEVPENDEIFLIQL 236
Score = 43.1 bits (100), Expect = 0.001
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 24/172 (13%)
Query: 450 TLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLL-NLRVGDAQGMFEPDGGGRPKGRLVA 508
T+VF P + L+ I+DD I E E F + LL + GDA L++
Sbjct: 330 TVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGDAV--------------LIS 375
Query: 509 PLLATVTILDDDHA-GIFSFQ----DRLLHVSE--CMGTVDVRVVRSSGARGTVRLPYRT 561
P + VTI +D G+ SF +R + + E ++ VVR+ G G V +
Sbjct: 376 PSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVVRNGGTHGNVSANWVL 435
Query: 562 VDGTARGGGV--HYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
+ V + G L F + + T+ + +VDD+ E+ + + +++
Sbjct: 436 TRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAYLLQI 487
Score = 43.1 bits (100), Expect = 0.001
Identities = 47/202 (23%), Positives = 82/202 (40%), Gaps = 21/202 (10%)
Query: 420 GGEGN-STFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHF 478
G GN S +V R + +D S G L F G+ + + ++DDD+ EE E +
Sbjct: 424 GTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEAEAY 483
Query: 479 FVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGI--FSFQDRLLHVSE 536
+++L + + EP A LL + DD + I F +++ + S
Sbjct: 484 LLQILPHTIRGGAEVSEP-----------AELLFYIQDSDDVYGLITFFPMENQKIESSP 532
Query: 537 CMGTVDVRVVRSSGARGTVRL-------PYRTVDGTARGGGVHYEDACGELEFGDDETMK 589
+ + R G +G VRL P VD G+ +L F + +T
Sbjct: 533 GERYLSLSFTRLGGTKGDVRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQV 592
Query: 590 TLQVKIVDDEEYEKKDNFFIEL 611
T ++ I +D + +F ++L
Sbjct: 593 TTKLPIRNDAFLQNGAHFLVQL 614
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/192 (26%), Positives = 84/192 (43%), Gaps = 30/192 (15%)
Query: 428 YVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRV 487
++ YR E + +++ + G L FKPGE + + + D I E DEH++V L
Sbjct: 809 FLHYRVEP---RDSNEFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVL----- 860
Query: 488 GDAQGMFEPDGGGRPKGRLVAPLLATVTIL-DDDHAGIFSF--QDRLLHVSECMG----T 540
G + +L + + +TIL +DD GI F ++ ++E G +
Sbjct: 861 ---------SSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVMINESKGDAIYS 911
Query: 541 VDVRVVRSSGARGTVRLPY-RTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDE 599
VVR+ G G V + + + D T V G + FGD E K + + + DE
Sbjct: 912 AVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQ-----GTVVFGDQEFSKNITIYSLPDE 966
Query: 600 EYEKKDNFFIEL 611
E+ + F + L
Sbjct: 967 IPEEMEEFTVIL 978
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/179 (26%), Positives = 76/179 (42%), Gaps = 23/179 (12%)
Query: 440 AGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG 499
A SD G L F+ GET K I DD+ E +E F ++L+++ GG
Sbjct: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVY-----------GG 1551
Query: 500 GRPKGRLVAPLLATVTILDDDHA-GIFSFQDRLL-HVSECMGTVDVRVVRSSGARGTVRL 557
R A +TI D+A G+F F + ++E T+ V R+ GA V +
Sbjct: 1552 ARISEENTT---ARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYVHV 1608
Query: 558 PYRTVDGTARGGGVHY-----EDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
Y G++Y +A G + F + + L + ++DD+ E + F + L
Sbjct: 1609 FYTI--SQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL 1665
Score = 40.8 bits (94), Expect = 0.006
Identities = 29/87 (33%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 443 DYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
D+E TL+F GE ++++ + I+DDD E E F+V L N + G AQ + E D G
Sbjct: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQ-GGAQIVEEKDDTG-- 5349
Query: 503 KGRLVAPLLATVTILDDDHAGIFSFQD 529
A + D H GI F +
Sbjct: 5350 ----FAAFAMVIITGSDLHNGIIGFSE 5372
Score = 40.0 bits (92), Expect = 0.010
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 21/142 (14%)
Query: 433 TEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQG 492
TE S+ D S+G +V + G K L+I I D E DE+F L
Sbjct: 3122 TEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTL---------- 3171
Query: 493 MFEPDGGGRPKGRLVAPLLATVTILDDD-HAGIFSF-----QDRLLHVSECMGTVDVRVV 546
F P GG RL + +T+L + G+FS + + + E TV + V
Sbjct: 3172 -FNPTGG----ARLGVHVQTLITVLQNQAPLGLFSISAVENRATSIDIEEANRTVYLNVS 3226
Query: 547 RSSGARGTVRLPYRTVDGTARG 568
R++G V + + TV TA G
Sbjct: 3227 RTNGIDLAVSVQWETVSETAFG 3248
Score = 38.1 bits (87), Expect = 0.038
Identities = 51/206 (24%), Positives = 86/206 (41%), Gaps = 23/206 (11%)
Query: 448 EGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLV 507
+GT+VF E K + I + D+I EE E F V LLN GG + R
Sbjct: 944 QGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLN-----------GTGGAKVGNRTT 992
Query: 508 APLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDG--T 565
AT+ I +D I+ + R++ V E T + V+R+ T + Y T DG T
Sbjct: 993 ----ATLRIRRNDDP-IYFAEPRVVRVQE-GETANFTVLRNGSVDVTCMVQYATKDGKAT 1046
Query: 566 ARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL----GQPQWLKRGI 621
AR + L F +++ + + +D E + F+I L G + G+
Sbjct: 1047 ARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYIILLNSTGDTVVYQYGV 1106
Query: 622 SALLLNQGDGDRKLTAEEEEARRIAE 647
+ +++ D + + E + + E
Sbjct: 1107 ATVIIEANDDPNGIFSLEPIDKAVEE 1132
Score = 37.7 bits (86), Expect = 0.050
Identities = 35/147 (23%), Positives = 62/147 (42%), Gaps = 23/147 (15%)
Query: 435 DGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMF 494
D + + G ++ + GT+ F GE K + + D I E +E +F++L+N+
Sbjct: 1160 DSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFNEFYFLKLVNI--------- 1210
Query: 495 EPDGGGRPKGRLVAPLLATVTIL---DDDHAGIFSFQDRLL--HVSECMGTVD------- 542
GG G +A VT++ +DD G+F L V+E + + D
Sbjct: 1211 --SGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLEREVAEDVLSEDDMSYITN 1268
Query: 543 VRVVRSSGARGTVRLPYRTVDGTARGG 569
++R G G V+L + + G
Sbjct: 1269 FTILRQQGVFGDVQLGWEILSSEFPAG 1295
Score = 37.7 bits (86), Expect = 0.050
Identities = 53/235 (22%), Positives = 100/235 (42%), Gaps = 29/235 (12%)
Query: 390 DDGASRIFFEP--SLYHCLENCGSVLLSVT-CQGGEGNSTFYVDYRTEDGSAKAGS-DYE 445
D+ I F+P + + E+ G +++ V G G T D+ ++ SA G DY
Sbjct: 4394 DNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT--ADFISQSSSASPGGVDYI 4451
Query: 446 YSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGR 505
T+ F+ G+ + I IIDD+ E +E + L GG GR
Sbjct: 4452 LHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGAT------------GGAVLGR 4499
Query: 506 LVAPLLATVTILDDDHAGIFSFQDR-LLHVSECMGTVDVRVV--RSSGARGTVRLPYRTV 562
+ + + D G+ F ++ + ++ T+ + +V R+ G G +++ + TV
Sbjct: 4500 HLVSRI--IIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETV 4557
Query: 563 DGTARGGGVHY-----EDACGELEFGDDE-TMKTLQVKIVDDEEYEKKDNFFIEL 611
++ + + G FG+ E ++T+ + I EE E ++ F I+L
Sbjct: 4558 GPNSQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKL 4612
Score = 37.4 bits (85), Expect = 0.065
Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 19/128 (14%)
Query: 440 AGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGG 499
A D G + F PGET + L + ++ DD+ E +E ++ +++ DA G
Sbjct: 2281 ATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEE-----VIQVQLTDASG------- 2328
Query: 500 GRPKGRLVAPLLATVTI-LDDDHAGIFSFQDRLLHVSECM---GTVDVRVVRSSGARGTV 555
G + +A + I +DD G +F + V E + ++ V RS G G +
Sbjct: 2329 ---GGTIGLDRIANIIIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRL 2385
Query: 556 RLPYRTVD 563
L Y T D
Sbjct: 2386 LLFYSTSD 2393
Score = 37.4 bits (85), Expect = 0.065
Identities = 41/208 (19%), Positives = 89/208 (42%), Gaps = 35/208 (16%)
Query: 413 LLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIF 472
L V GG+G T +++ ++ KA + GTL F E+QK + + + D +
Sbjct: 4058 LTVVRSPGGKG--TVRLEWTIDE---KAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVL 4112
Query: 473 EEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTIL---DDDHAGIFSFQD 529
EED F ++L+++ + ++P+ + +I+ D +G
Sbjct: 4113 EEDRRFTIQLISIDEVE-----------------ISPVKGSASIIIRGDKRASGEVGIAP 4155
Query: 530 RLLHV------SECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFG 583
H+ ++ GT + +VR G G V + +R + + + G+L
Sbjct: 4156 SSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVG----EFAETSGKLTMR 4211
Query: 584 DDETMKTLQVKIVDDEEYEKKDNFFIEL 611
D+++ + ++ ++D+ E+K + +L
Sbjct: 4212 DEQSAVIVVIQALNDDIPEEKSFYEFQL 4239
Score = 36.2 bits (82), Expect = 0.14
Identities = 36/133 (27%), Positives = 58/133 (43%), Gaps = 27/133 (20%)
Query: 509 PLLATVTILDDDHAGIFSFQDRLLHVSECM-----GTVDVRVVRSSGARGTVR------- 556
P +ATVT H G FS ++++ E M T +V + R+ G G V
Sbjct: 5205 PDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSITVKTFG 5263
Query: 557 ----------LPYRTVDGTARGGGV----HYEDACGELEFGDDETMKTLQVKIVDDEEYE 602
LP+R + G + +E+ L F D E + + V+I+DD+E E
Sbjct: 5264 ERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPE 5323
Query: 603 KKDNFFIELGQPQ 615
++ F++ L PQ
Sbjct: 5324 GQEFFYVFLTNPQ 5336
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 429 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVG 488
V + E G D +G + F PG + ++DD++ E DE F ++L ++ G
Sbjct: 183 VTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGG 242
Score = 30.8 bits (68), Expect = 6.1
Identities = 15/38 (39%), Positives = 23/38 (60%)
Query: 578 GELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQ 615
GEL F E T+ V I+DD EK+++F ++L P+
Sbjct: 3592 GELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629
Score = 30.8 bits (68), Expect = 6.1
Identities = 39/196 (19%), Positives = 76/196 (38%), Gaps = 26/196 (13%)
Query: 443 DYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
D+ + G GE++ + ++ D++ E +E + ++L+++ GG
Sbjct: 4695 DFLSTSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVE------------GGAE 4742
Query: 503 KGRLVAPLLATVTILDDDHAGIFSFQDR--LLHVSECMGTVDVRVVRSSGARGTVRLPYR 560
+ +V DD H + DR +L + ++ + + R +G G V + R
Sbjct: 4743 LDLEKSITWFSVYANDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVGLR 4802
Query: 561 TVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL--------- 611
+ + + E+A +L D T K V I + NF ++L
Sbjct: 4803 -ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVGGR 4861
Query: 612 --GQPQWLKRGISALL 625
G P L+ SA+L
Sbjct: 4862 FYGMPTILQEAKSAVL 4877
Score = 30.8 bits (68), Expect = 6.1
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 3/107 (2%)
Query: 508 APLLATVTILDDDHAGIFSFQ--DRLLHVSECMGTVDVRVVRSSGARGT-VRLPYRTVDG 564
A L + + + + G+F F R + VSE + + V R G +++ Y+T G
Sbjct: 4988 AQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAG 5047
Query: 565 TARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIEL 611
+A+ GEL F +T ++ I++D+ E ++ F+I L
Sbjct: 5048 SAKPLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 66.2 bits (160), Expect = 1e-10
Identities = 56/179 (31%), Positives = 84/179 (46%), Gaps = 16/179 (8%)
Query: 705 DEEEEEDGSREERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACF 752
DEEEEED +E + FD L TV W VL+ VP P F
Sbjct: 421 DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF 480
Query: 753 GVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCAD 812
S L I + ++ + + G T+G+ D + + F+A GTS+PD AS + A Q D
Sbjct: 481 ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GD 539
Query: 813 ASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQ-GRPFEVRTGTLAFSVTLFTVFAFVGI 870
++ N GSN ++ +GLG+ W++ + AV G + + L +SV L FV +
Sbjct: 540 MAVSNSIGSNVFDILIGLGLPWALQTL--AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
Score = 58.5 bits (140), Expect = 3e-08
Identities = 59/217 (27%), Positives = 96/217 (44%), Gaps = 43/217 (19%)
Query: 34 NDSDTST-GGCQGSYRCQPGVLLPVWEPDDPSLGD--KAARAVVYFVAMVYMFLGVSIIA 90
ND+ TS G + S C L P+D + + V++ + +YMF ++I+
Sbjct: 71 NDTLTSEDAGLRNSKNCTEPALHEF--PNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVC 128
Query: 91 DRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIE 149
D F ++E I + +E V+ T MA GSSAPE+ SVI
Sbjct: 129 DDFFVPSLEKICERLH------------------LSEDVAGATFMAAGSSAPELFTSVIG 170
Query: 150 VCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASW----- 204
V G++G GTIVGSA FN+ +I VC + AG+ +SW
Sbjct: 171 VF---ITKGDVGVGTIVGSAVFNILCIIGVC--GLFAGQ---------VVALSSWCLLRD 216
Query: 205 SIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVV 241
SI+ + + ++ V WE+L+ ++ + + +V
Sbjct: 217 SIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIV 253
Score = 32.7 bits (73), Expect = 1.6
Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGV 832
L + V F+A G+S P+ F S + + D +G + GS N+ +GV
Sbjct: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGV 197
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 65.1 bits (157), Expect = 3e-10
Identities = 74/278 (26%), Positives = 107/278 (38%), Gaps = 42/278 (15%)
Query: 394 SRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGS---------DY 444
S I F+ + Y+ E GSV ++V + G N V RTE G+A + S DY
Sbjct: 2552 SLISFKYTSYNVSEKAGSVSVTVQ-RTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDY 2610
Query: 445 EYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKG 504
G + F E K I I DDD+FE E F V L P
Sbjct: 2611 VEYAGQVQFDEREDTKSCTIVINDDDVFENVESFTVEL-----------------SMPAY 2653
Query: 505 RLVAPLL-ATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVD 563
L+ A V I D + F ++ V+E G + + R A V TV
Sbjct: 2654 ALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVP 2713
Query: 564 GTARGGGVHYED-----------ACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELG 612
+A G ++ + A + FG TM T V ++DD EYE+++ F I L
Sbjct: 2714 KSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALA 2773
Query: 613 QPQ---WLKRGISALLLNQGDGDRKLTAEEEEARRIAE 647
+ R +A +L G D + A ++E
Sbjct: 2774 DASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSE 2811
Score = 54.7 bits (130), Expect = 4e-07
Identities = 50/189 (26%), Positives = 85/189 (44%), Gaps = 21/189 (11%)
Query: 433 TEDGSAKAGSDYEYSEGT----LVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVG 488
T+ SA+ D+E + + F G+ K + I DD +FE +E F V L
Sbjct: 2956 TQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYL------ 3009
Query: 489 DAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMG-----TVDV 543
G+ P G R+ +AT+TI +D+ A F++ V E G +++
Sbjct: 3010 ---GL--PLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGPDAIAILNI 3064
Query: 544 RVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEK 603
+V+R T ++ T DG+A+ GV Y L+F +V+I+ +E+ E
Sbjct: 3065 KVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREW 3123
Query: 604 KDNFFIELG 612
++F + LG
Sbjct: 3124 HESFSLVLG 3132
Score = 50.1 bits (118), Expect = 1e-05
Identities = 55/235 (23%), Positives = 94/235 (40%), Gaps = 32/235 (13%)
Query: 398 FEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDY---RTEDGSA----KAGSDYEY---- 446
F+ +Y E+ G + + +G + + Y ++ GS+ ++GSD++
Sbjct: 2677 FDKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMS 2736
Query: 447 SEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRL 506
+ ++F PG T + +IDD +EE+E F + L + R+
Sbjct: 2737 AASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALAD---------------ASDNARI 2781
Query: 507 VAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGT---VRLPYRTVD 563
A V I + A S + VSE GTV + V+R T V R D
Sbjct: 2782 GRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSD 2841
Query: 564 GTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEY---EKKDNFFIELGQPQ 615
+ GV Y + ++EFG + + I+DD +Y E + F + L Q
Sbjct: 2842 PASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQ 2896
Score = 43.9 bits (102), Expect = 7e-04
Identities = 40/139 (28%), Positives = 59/139 (42%), Gaps = 20/139 (14%)
Query: 390 DDGASRIFFEPSLYHCLENCGSVLLSV----TCQGGEGNSTFYVDYRTEDGSAKAGSDYE 445
D+ A I FE + Y E G +++ + G+ N T V T DGSA++G DY
Sbjct: 3035 DEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYY 3094
Query: 446 YSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGR 505
L F PG ++ I+ ++ E E F + L G P
Sbjct: 3095 PKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVL---------------GPDDPVEA 3139
Query: 506 LVAPL-LATVTILDDDHAG 523
++ + ATVTILD + AG
Sbjct: 3140 VLGDVTTATVTILDQEAAG 3158
Score = 39.7 bits (91), Expect = 0.013
Identities = 65/276 (23%), Positives = 102/276 (36%), Gaps = 33/276 (11%)
Query: 393 ASRIFFEPSLYHCLENCGSVLLSVTCQGGEGN---STFYVDYRTEDGSAKAGSDYEYSEG 449
AS + + + E+ G+V + V G + + S + ++ SA G DY S
Sbjct: 2797 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSR 2856
Query: 450 TLVFKPGETQKELRIGIIDD---DIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRL 506
+ F PG ++ + I+DD + E E F V L AQG L
Sbjct: 2857 KVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFL-----SSAQG-----------AEL 2900
Query: 507 VAPLLATVTILDD-DHAGIFSFQDRLLHVSECMGTVDVRVVRSS--GARGTVRLPYRTVD 563
P A + I D F LL V E G + V + RS +VR ++
Sbjct: 2901 TKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHS 2960
Query: 564 GTARGGGVHYEDA-CGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP---QW--- 616
++A + F + +K V I DD +E ++ F + LG P W
Sbjct: 2961 AQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLPLGNHWSGA 3020
Query: 617 -LKRGISALLLNQGDGDRKLTAEEEEARRIAEMGKP 651
+ + A + D D EE A ++ E P
Sbjct: 3021 RIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGP 3056
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 63.9 bits (154), Expect = 6e-10
Identities = 65/221 (29%), Positives = 98/221 (44%), Gaps = 55/221 (24%)
Query: 23 TPTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFV-AMVY 81
+P+PS+ PP D +G Y PD S+ ++ VV V M+Y
Sbjct: 421 SPSPSVLPPSLPDLHP-----KGEY-----------PPDLFSVEERRQGWVVLHVFGMMY 464
Query: 82 MFLGVSIIADR-FMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSA 140
+F+ ++I+ D F+ A+ VIT K + +E V+ T MA G SA
Sbjct: 465 VFVALAIVCDEYFVPALGVITDKLQI------------------SEDVAGATFMAAGGSA 506
Query: 141 PEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFV 200
PE+ S+I V +G GTIVGSA FN+ VI C SR+I +L
Sbjct: 507 PELFTSLIGVF---ISHSNVGIGTIVGSAVFNILFVIGTCSLF-----SREILNL----- 553
Query: 201 TASWSIFAYVWLY-----LILAVFSPGVVQVWEALLTLVFF 236
W +F V Y +++ F ++ WE+LL L+ +
Sbjct: 554 -TWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAY 593
Score = 52.0 bits (123), Expect = 3e-06
Identities = 48/176 (27%), Positives = 76/176 (43%), Gaps = 17/176 (9%)
Query: 705 DEEEEEDGSREERLPSCFDY--------VMHFLTVFWKVLFACVPPTEYCHGWACFGV-- 754
+EEEEE G+ E P D+ + FL L+ VP F
Sbjct: 885 EEEEEEKGNEE---PLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTF 941
Query: 755 --SILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCAD 812
SI+ I + + L+ A G T+G+ + + + +A GTSIPD S + A + D
Sbjct: 942 LGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA-RKGLGD 1000
Query: 813 ASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFV 868
++ + GSN ++ +GL V W + ++ +Q P G V LF + FV
Sbjct: 1001 MAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVS-SNGLFCAIVLLFLMLLFV 1055
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 63.5 bits (153), Expect = 8e-10
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 38/248 (15%)
Query: 389 EDDGASRIFFEPS----LYHCLE------NCGSVLLSVTC-QGGEGNSTFYVDYRTEDGS 437
ED+G +++ +P + CLE + S L VT + G T ++ T+D +
Sbjct: 1756 EDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDET 1815
Query: 438 AKAGSDYEYSEGTLV-FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEP 496
AK D+++ + F PG+T R+ II D+ +E E F + L EP
Sbjct: 1816 AKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILS-----------EP 1864
Query: 497 DGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVR 556
L P +ATV I+D + + E +G + + V RS A +
Sbjct: 1865 -----LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELI 1919
Query: 557 LPYRTVDGTARG---GGVHY-------EDACGELEFGDDETMKTLQVKIVDDEEYEKKDN 606
+ T G+A G V + ED L F +ET KT QV I+DD YE++++
Sbjct: 1920 VICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEES 1979
Query: 607 FFIELGQP 614
F + L P
Sbjct: 1980 FSVSLRLP 1987
Score = 57.4 bits (137), Expect = 6e-08
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 31/220 (14%)
Query: 394 SRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAG-------SDY-- 444
S ++ + Y E+ G +L+ V + G+ + V T GSA SDY
Sbjct: 1886 STVYIPEAEYKIEEDIGELLIPVR-RSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
Query: 445 --EYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
E L F ETQK ++ IIDD ++EE+E F V L L VG G P
Sbjct: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL-RLPVGGQLGARFPT----- 1998
Query: 503 KGRLVAPLLATVTILDDDH-AGIFSFQDRLLHVSECMGTVDVRVVRSS---GARGTVRLP 558
VTIL D + + F D HV+E V+V V R ++ +
Sbjct: 1999 ---------TKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVR 2049
Query: 559 YRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDD 598
R + + G Y L+F M+T QV I+DD
Sbjct: 2050 SRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 63.5 bits (153), Expect = 8e-10
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 38/248 (15%)
Query: 389 EDDGASRIFFEPS----LYHCLE------NCGSVLLSVTC-QGGEGNSTFYVDYRTEDGS 437
ED+G +++ +P + CLE + S L VT + G T ++ T+D +
Sbjct: 1756 EDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDET 1815
Query: 438 AKAGSDYEYSEGTLV-FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEP 496
AK D+++ + F PG+T R+ II D+ +E E F + L EP
Sbjct: 1816 AKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILS-----------EP 1864
Query: 497 DGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVR 556
L P +ATV I+D + + E +G + + V RS A +
Sbjct: 1865 -----LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELI 1919
Query: 557 LPYRTVDGTARG---GGVHY-------EDACGELEFGDDETMKTLQVKIVDDEEYEKKDN 606
+ T G+A G V + ED L F +ET KT QV I+DD YE++++
Sbjct: 1920 VICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEES 1979
Query: 607 FFIELGQP 614
F + L P
Sbjct: 1980 FSVSLRLP 1987
Score = 57.4 bits (137), Expect = 6e-08
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 31/220 (14%)
Query: 394 SRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAG-------SDY-- 444
S ++ + Y E+ G +L+ V + G+ + V T GSA SDY
Sbjct: 1886 STVYIPEAEYKIEEDIGELLIPVR-RSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
Query: 445 --EYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
E L F ETQK ++ IIDD ++EE+E F V L L VG G P
Sbjct: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL-RLPVGGQLGARFPT----- 1998
Query: 503 KGRLVAPLLATVTILDDDH-AGIFSFQDRLLHVSECMGTVDVRVVRSS---GARGTVRLP 558
VTIL D + + F D HV+E V+V V R ++ +
Sbjct: 1999 ---------TKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVR 2049
Query: 559 YRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDD 598
R + + G Y L+F M+T QV I+DD
Sbjct: 2050 SRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 63.5 bits (153), Expect = 8e-10
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 38/248 (15%)
Query: 389 EDDGASRIFFEPS----LYHCLE------NCGSVLLSVTC-QGGEGNSTFYVDYRTEDGS 437
ED+G +++ +P + CLE + S L VT + G T ++ T+D +
Sbjct: 1756 EDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDET 1815
Query: 438 AKAGSDYEYSEGTLV-FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEP 496
AK D+++ + F PG+T R+ II D+ +E E F + L EP
Sbjct: 1816 AKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILS-----------EP 1864
Query: 497 DGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVR 556
L P +ATV I+D + + E +G + + V RS A +
Sbjct: 1865 -----LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELI 1919
Query: 557 LPYRTVDGTARG---GGVHY-------EDACGELEFGDDETMKTLQVKIVDDEEYEKKDN 606
+ T G+A G V + ED L F +ET KT QV I+DD YE++++
Sbjct: 1920 VICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEES 1979
Query: 607 FFIELGQP 614
F + L P
Sbjct: 1980 FSVSLRLP 1987
Score = 57.4 bits (137), Expect = 6e-08
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 31/220 (14%)
Query: 394 SRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAG-------SDY-- 444
S ++ + Y E+ G +L+ V + G+ + V T GSA SDY
Sbjct: 1886 STVYIPEAEYKIEEDIGELLIPVR-RSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
Query: 445 --EYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
E L F ETQK ++ IIDD ++EE+E F V L L VG G P
Sbjct: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL-RLPVGGQLGARFPT----- 1998
Query: 503 KGRLVAPLLATVTILDDDH-AGIFSFQDRLLHVSECMGTVDVRVVRSS---GARGTVRLP 558
VTIL D + + F D HV+E V+V V R ++ +
Sbjct: 1999 ---------TKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVR 2049
Query: 559 YRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDD 598
R + + G Y L+F M+T QV I+DD
Sbjct: 2050 SRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
F + L I + + ++ L + G T+G+ D + + F+A GTS+PD AS + A Q
Sbjct: 393 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 451
Query: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTL 861
D ++ N GSN ++ +GLGV W + + G ++ + L +SV L
Sbjct: 452 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 500
Score = 56.2 bits (134), Expect = 1e-07
Identities = 47/165 (28%), Positives = 80/165 (48%), Gaps = 28/165 (16%)
Query: 73 VVYFVAMVYMFLGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
+++ + +YMF ++I+ D F ++E I + +E V+
Sbjct: 37 LLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGA 78
Query: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRK 191
T MA GSS PE+ SVI V G++G GTIVGSA FN+ +I VC + AG+ +
Sbjct: 79 TFMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVC--GLFAGQVVR 133
Query: 192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFF 236
+ V + ++I V LI+ ++ +V WE L+ ++ +
Sbjct: 134 LTWWAVCRDSVYYTISVIV---LIVFIYDEQIVW-WEGLVLIILY 174
Score = 35.4 bits (80), Expect = 0.25
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)
Query: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAA 838
L + V F+A G+S P+ FAS + D +G + GS N+ +GV A
Sbjct: 71 LSEDVAGATFMAAGSSTPELFASVIGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAG 129
Query: 839 -----VYWAV 843
+WAV
Sbjct: 130 QVVRLTWWAV 139
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
F + L I + + ++ L + G T+G+ D + + F+A GTS+PD AS + A Q
Sbjct: 421 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 479
Query: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTL 861
D ++ N GSN ++ +GLGV W + + G ++ + L +SV L
Sbjct: 480 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 528
Score = 56.2 bits (134), Expect = 1e-07
Identities = 47/165 (28%), Positives = 80/165 (48%), Gaps = 28/165 (16%)
Query: 73 VVYFVAMVYMFLGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
+++ + +YMF ++I+ D F ++E I + +E V+
Sbjct: 84 LLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGA 125
Query: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRK 191
T MA GSS PE+ SVI V G++G GTIVGSA FN+ +I VC + AG+ +
Sbjct: 126 TFMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVC--GLFAGQVVR 180
Query: 192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFF 236
+ V + ++I V LI+ ++ +V WE L+ ++ +
Sbjct: 181 LTWWAVCRDSVYYTISVIV---LIVFIYDEQIVW-WEGLVLIILY 221
Score = 35.4 bits (80), Expect = 0.25
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)
Query: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAA 838
L + V F+A G+S P+ FAS + D +G + GS N+ +GV A
Sbjct: 118 LSEDVAGATFMAAGSSTPELFASVIGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAG 176
Query: 839 -----VYWAV 843
+WAV
Sbjct: 177 QVVRLTWWAV 186
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 2/110 (1%)
Query: 752 FGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCA 811
F + L I + + ++ L + G T+G+ D + + F+A GTS+PD AS + A Q
Sbjct: 440 FITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG-LG 498
Query: 812 DASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTL 861
D ++ N GSN ++ +GLGV W + + G ++ + L +SV L
Sbjct: 499 DMAVSNTIGSNVFDILVGLGVPWGLQTMV-VNYGSTVKINSRGLVYSVVL 547
Score = 56.2 bits (134), Expect = 1e-07
Identities = 47/165 (28%), Positives = 80/165 (48%), Gaps = 28/165 (16%)
Query: 73 VVYFVAMVYMFLGVSIIADRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
+++ + +YMF ++I+ D F ++E I + +E V+
Sbjct: 84 LLHILGALYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGA 125
Query: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRK 191
T MA GSS PE+ SVI V G++G GTIVGSA FN+ +I VC + AG+ +
Sbjct: 126 TFMAAGSSTPELFASVIGVF---ITHGDVGVGTIVGSAVFNILCIIGVC--GLFAGQVVR 180
Query: 192 IKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFF 236
+ V + ++I V LI+ ++ +V WE L+ ++ +
Sbjct: 181 LTWWAVCRDSVYYTISVIV---LIVFIYDEQIVW-WEGLVLIILY 221
Score = 35.4 bits (80), Expect = 0.25
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 6/70 (8%)
Query: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAA 838
L + V F+A G+S P+ FAS + D +G + GS N+ +GV A
Sbjct: 118 LSEDVAGATFMAAGSSTPELFASVIGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAG 176
Query: 839 -----VYWAV 843
+WAV
Sbjct: 177 QVVRLTWWAV 186
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/109 (32%), Positives = 61/109 (55%), Gaps = 22/109 (20%)
Query: 73 VVYFVAMVYMFLGVSIIADR-FMAAIEVITSKEKEITITKANGETSVGTVRIWNETVSNL 131
++YF+ +VYMF+ +SI+ D F+ ++E+I+ S+G ++ V+
Sbjct: 70 IIYFLIIVYMFMAISIVCDEYFLPSLEIISE--------------SLGL----SQDVAGT 111
Query: 132 TLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVC 180
T MA GSSAPE++ + + G G++G TI+GSA +N+ + A C
Sbjct: 112 TFMAAGSSAPELVTAFL---GVFITKGDIGISTILGSAIYNLLGICAAC 157
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 19/143 (13%)
Query: 732 FWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVAL 791
FWK F F +S + I T ++ + + G T+ + D+V + +A
Sbjct: 329 FWKNYFVIT-----------FFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA 377
Query: 792 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQG-RPFEV 850
GTSIPDT AS + A + + D ++ N+ GSN ++ L LG+ W + + + G P EV
Sbjct: 378 GTSIPDTIASVLVARKGK-GDMAMSNIVGSNVFDM-LCLGIPWFIKTAF--INGSAPAEV 433
Query: 851 RTGTLAF---SVTLFTVFAFVGI 870
+ L + S+ + +F F+ +
Sbjct: 434 NSRGLTYITISLNISIIFLFLAV 456
Score = 32.0 bits (71), Expect = 2.7
Identities = 18/48 (37%), Positives = 27/48 (56%), Gaps = 3/48 (6%)
Query: 126 ETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNM 173
+TV LTL+A G+S P+ + SV+ G++ IVGS F+M
Sbjct: 367 DTVMGLTLLAAGTSIPDTIASVLVA---RKGKGDMAMSNIVGSNVFDM 411
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 55.1 bits (131), Expect = 3e-07
Identities = 64/233 (27%), Positives = 98/233 (42%), Gaps = 33/233 (14%)
Query: 396 IFFEPSLYHCLENCGSVLLSVTCQG-GEGNSTFYVDYRTEDGSAKAGSDYE-YSEGTLVF 453
I FE Y L N S L V + G T ++ T D +A+ D++ ++ + F
Sbjct: 1771 ISFEKEYY--LVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQF 1828
Query: 454 KPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLAT 513
PG+T+ R+ I+ D E+ E F V L EP L P +AT
Sbjct: 1829 NPGQTRATWRVRILSDGEHEQSETFQVVLS-----------EP-----VLAALEFPTVAT 1872
Query: 514 VTILDD-DHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARG---- 568
V I+D D +F Q + V E +G + + + RS + + T GTA G
Sbjct: 1873 VEIVDPGDEPTVFIPQSKY-SVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPT 1931
Query: 569 GGVHY-------EDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP 614
+ Y ED + F DE K ++ I+DD YE+++ F + L P
Sbjct: 1932 SVLSYSDYISRPEDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMP 1984
Score = 41.2 bits (95), Expect = 0.004
Identities = 61/239 (25%), Positives = 100/239 (41%), Gaps = 29/239 (12%)
Query: 388 DEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYR---TEDGSAKAGSDY 444
D+DD +F Y E+ G V + V G + + + V R T+ SA AG+DY
Sbjct: 2003 DKDDEPI-FYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDY 2061
Query: 445 EYSEGTLVFKPGETQKELRIGIIDD---DIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGR 501
L F PG + +R+ I+DD E E F + +L + + A G
Sbjct: 2062 VGISRNLDFAPGVNMQPVRVVILDDLGQPALEGIEKFEL-VLRMPMNAALG--------- 2111
Query: 502 PKGRLVAPLLATVTILDD-DHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYR 560
P ATV+I D F++R+ SE G + + R+ + +
Sbjct: 2112 ------EPSKATVSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTGDVQYRSSVRCY 2165
Query: 561 TVDGTARGGGVHYEDA----CGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQ 615
T G+A+ + +E+ + F ET K ++++DD YE+ + + LG PQ
Sbjct: 2166 TRQGSAQ-VMMDFEERPNTDTSIITFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQ 2223
Score = 40.4 bits (93), Expect = 0.008
Identities = 23/62 (37%), Positives = 31/62 (50%)
Query: 421 GEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFV 480
G+ + V T+DGSA +G DY + FK GETQ + I + D + E E F V
Sbjct: 2280 GDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIEVTFDGVREMREAFTV 2339
Query: 481 RL 482
L
Sbjct: 2340 HL 2341
>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
Length = 1805
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 511 LATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGG 570
L +TI+ + + SF+ VS + V+R G ++ YRT DGTA+G
Sbjct: 978 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNR 1037
Query: 571 VHYEDACGELEFGDDETMKTLQVKIVDDEEYE------KKDNFFIELGQPQW 616
Y GEL F E K LQVK+++ +E + + F ++L P++
Sbjct: 1038 -DYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKF 1088
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/66 (37%), Positives = 39/66 (59%), Gaps = 6/66 (9%)
Query: 429 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIID----DDIF--EEDEHFFVRL 482
V YRT+DG+A+ DY EG L+F+PGE KEL++ +++ D + + F V+L
Sbjct: 1024 VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQL 1083
Query: 483 LNLRVG 488
N + G
Sbjct: 1084 SNPKFG 1089
>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
Length = 1822
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 511 LATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGG 570
L +TI+ + + SF+ VS + V+R G ++ YRT DGTA+G
Sbjct: 978 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNR 1037
Query: 571 VHYEDACGELEFGDDETMKTLQVKIVDDEEYE------KKDNFFIELGQPQW 616
Y GEL F E K LQVK+++ +E + + F ++L P++
Sbjct: 1038 -DYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKF 1088
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/66 (37%), Positives = 39/66 (59%), Gaps = 6/66 (9%)
Query: 429 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIID----DDIF--EEDEHFFVRL 482
V YRT+DG+A+ DY EG L+F+PGE KEL++ +++ D + + F V+L
Sbjct: 1024 VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQL 1083
Query: 483 LNLRVG 488
N + G
Sbjct: 1084 SNPKFG 1089
>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
Length = 1752
Score = 45.4 bits (106), Expect = 2e-04
Identities = 33/112 (29%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 511 LATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGG 570
L +TI+ + + SF+ VS + V+R G ++ YRT DGTA+G
Sbjct: 978 LVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNR 1037
Query: 571 VHYEDACGELEFGDDETMKTLQVKIVDDEEYE------KKDNFFIELGQPQW 616
Y GEL F E K LQVK+++ +E + + F ++L P++
Sbjct: 1038 -DYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKF 1088
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/66 (37%), Positives = 39/66 (59%), Gaps = 6/66 (9%)
Query: 429 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIID----DDIF--EEDEHFFVRL 482
V YRT+DG+A+ DY EG L+F+PGE KEL++ +++ D + + F V+L
Sbjct: 1024 VSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQL 1083
Query: 483 LNLRVG 488
N + G
Sbjct: 1084 SNPKFG 1089
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 37.0 bits (84), Expect = 0.084
Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 32/167 (19%)
Query: 762 LTALIGDLASHFGC--------TVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADA 813
L ++G A+ F C T+ L +V V F+A G PD F++ VA A
Sbjct: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
Query: 814 SIGNVTGSNAVNVFLGLGVAWSVAAVY-WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAV 872
++G + G+ V + VA + ++ + RPF F +F + A +
Sbjct: 170 ALGALFGA---GVLVTTVVAGGITILHPFMAASRPF--------FRDIVFYMVAVFLTFL 218
Query: 873 LLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIR 919
+L+R R + LG +LGL++ Y++ L + + R
Sbjct: 219 MLFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIYQR 253
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 37.0 bits (84), Expect = 0.084
Identities = 32/100 (32%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 394 SRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLV- 452
S I + + Y EN G + L + +G +S F V + SA G D+ L+
Sbjct: 1741 SHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAF-VGIKVNQVSAAVGKDFTVIPSKLIQ 1799
Query: 453 FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQG 492
F PG + K I I D + E+DE F V +LN V G
Sbjct: 1800 FDPGMSTKMWNIAITYDGLEEDDEVFEV-ILNSPVNAVLG 1838
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 35.8 bits (81), Expect = 0.19
Identities = 23/53 (43%), Positives = 28/53 (52%), Gaps = 2/53 (3%)
Query: 24 PTPSLPPPPANDSDTSTGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYF 76
P P LPP +DSD +GG G R +LLP DP L +AA AV +F
Sbjct: 371 PLP-LPPDSDSDSDAGSGGSSG-LRLTAQLLLPGEATQDPPLPTRAAAAVNFF 421
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,149,066
Number of Sequences: 37866
Number of extensions: 1819510
Number of successful extensions: 8218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 7972
Number of HSP's gapped (non-prelim): 118
length of query: 921
length of database: 18,247,518
effective HSP length: 112
effective length of query: 809
effective length of database: 14,006,526
effective search space: 11331279534
effective search space used: 11331279534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.