Search of human proteins with 56961680

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
         (872 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|56961680 coiled-coil domain containing 147 [Homo sapiens]         1669   0.0  
gi|100814339 coiled-coil domain containing 146 [Homo sapiens]         182   2e-45
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    139   1e-32
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            137   4e-32
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   137   6e-32
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       134   3e-31
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       134   3e-31
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        134   3e-31
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        134   3e-31
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        134   3e-31
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        134   3e-31
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        134   3e-31
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        134   3e-31
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   134   5e-31
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   132   2e-30
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   132   2e-30
gi|71061468 centromere protein E [Homo sapiens]                       131   2e-30
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   131   3e-30
gi|118498368 kinectin 1 isoform c [Homo sapiens]                      130   4e-30
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   130   4e-30
gi|118498356 kinectin 1 isoform a [Homo sapiens]                      130   5e-30
gi|33620775 kinectin 1 isoform a [Homo sapiens]                       130   5e-30
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   130   7e-30
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   130   7e-30
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   130   7e-30
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   130   7e-30
gi|221219020 NYD-SP11 protein [Homo sapiens]                          129   2e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    129   2e-29
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...   127   4e-29
gi|118498362 kinectin 1 isoform b [Homo sapiens]                      126   8e-29

>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 1669 bits (4323), Expect = 0.0
 Identities = 872/872 (100%), Positives = 872/872 (100%)

Query: 1   MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL 60
           MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL
Sbjct: 1   MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL 60

Query: 61  MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
           MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI
Sbjct: 61  MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120

Query: 121 LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT 180
           LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT
Sbjct: 121 LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT 180

Query: 181 EQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIK 240
           EQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIK
Sbjct: 181 EQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIK 240

Query: 241 ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
           ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ
Sbjct: 241 ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300

Query: 301 ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
           ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG
Sbjct: 301 ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360

Query: 361 LEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGE 420
           LEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGE
Sbjct: 361 LEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGE 420

Query: 421 IQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAES 480
           IQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAES
Sbjct: 421 IQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAES 480

Query: 481 EIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESAL 540
           EIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESAL
Sbjct: 481 EIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESAL 540

Query: 541 VKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQK 600
           VKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQK
Sbjct: 541 VKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQK 600

Query: 601 KELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIK 660
           KELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIK
Sbjct: 601 KELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIK 660

Query: 661 KLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASD 720
           KLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASD
Sbjct: 661 KLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASD 720

Query: 721 PNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY 780
           PNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY
Sbjct: 721 PNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY 780

Query: 781 RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKD 840
           RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKD
Sbjct: 781 RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKD 840

Query: 841 TAPMDNTFLMVKPNGPGFTGGGFPLRSTKMTF 872
           TAPMDNTFLMVKPNGPGFTGGGFPLRSTKMTF
Sbjct: 841 TAPMDNTFLMVKPNGPGFTGGGFPLRSTKMTF 872


>gi|100814339 coiled-coil domain containing 146 [Homo sapiens]
          Length = 955

 Score =  182 bits (461), Expect = 2e-45
 Identities = 178/871 (20%), Positives = 397/871 (45%), Gaps = 61/871 (7%)

Query: 27  LHELSGDKSLEKFRI-----EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATA 81
           LHEL     L   R+     +Y  LH  +  + ++E +L+   +    +I      +  A
Sbjct: 50  LHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQA 109

Query: 82  LKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLS 141
               +   T ++ +++++ K     ++  ++E   +  + +LKEE + + K  E+ +   
Sbjct: 110 DNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPG 169

Query: 142 MDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQ 201
            +    ++ L    EE+ KE  Q   E+  LRE LA   +Q  + ++  EE        +
Sbjct: 170 -EMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLK 228

Query: 202 QEIQQRQN-------EASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQ 254
            E+   Q        E  +  RKK ++EK+   ++ ++ +    +K ++  V    +E +
Sbjct: 229 DEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKE 288

Query: 255 KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL------- 307
            + ++++ ++ L E   +E  Q  ++  +L +ENE  SL    +   N + +L       
Sbjct: 289 NVIKEVEGKRALLEIKEREHNQL-VKLLELARENEATSLTERGILDLNLRNSLIDKQNYH 347

Query: 308 -ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE 366
            EL  K+ E  +   ++ K+  + +     L  T+        H+  L         E+E
Sbjct: 348 DELSRKQREKERDFRNLRKMELLLKVSWDALRQTQ------ALHQRLLL--------EME 393

Query: 367 ASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKD 426
           A  K      +   EL +E ++  +N+ +    ++ ++ LV+     +  L  E +N K+
Sbjct: 394 AIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKE 453

Query: 427 EAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ 486
                 ++      E+++         QK    ++++K ++ +I  ++KK  E   +L++
Sbjct: 454 LVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLRE 513

Query: 487 QQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
              LY+ +R++RN +   L +A  ++ ++K + K+ +++++ L+    ++E  L    L+
Sbjct: 514 FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLK 573

Query: 547 QQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                  +E+++ +++K+  +  E K   E Q     +L   I   + E ++ +K  ++ 
Sbjct: 574 HANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKA 633

Query: 607 ISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREK 666
           +  R+  G QL+ R +E+ + YEKI IQ+ +   GE + +   E ++ L+++I + +R+ 
Sbjct: 634 VQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQI 693

Query: 667 GILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYEL 726
            +  + +     L  +   +Q +  +   R + LE++   P   +R R L   D    E+
Sbjct: 694 CVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEM 753

Query: 727 IQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMEL--KHVLARQPGPEAAEQLKLYRRTL 784
           IQK+  L+ +L  K E+++EK+ + ++  +L   L  K    +Q     A+++  Y+R +
Sbjct: 754 IQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRI 813

Query: 785 HDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNEL--------------QNLKKKYLAQK 830
            +  +++  L +EL+M +  + E + EV +  + +              + ++K++L   
Sbjct: 814 KNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVL 873

Query: 831 RKEQL------QKNKDTAPMDNTFLMVKPNG 855
           R E++      +K+++    DN  L   PNG
Sbjct: 874 RDEEMHALAIAEKSQEFLEADNRQL---PNG 901


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  139 bits (349), Expect = 1e-32
 Identities = 175/849 (20%), Positives = 384/849 (45%), Gaps = 82/849 (9%)

Query: 20   ERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL-NAEIVVNSAKV 78
            +++ + + H+L      E+ R ++  L A  KK   N + L  +  E  +A   +   KV
Sbjct: 910  KQELEEICHDLEARVEEEEERCQH--LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967

Query: 79   ATALKLS--QDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
             T  KL   +++Q  +     ++ K  K+++   D+  +    +   +E+  +L KL  +
Sbjct: 968  TTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAEFTTNLTEEEEKSKSLAKLKNK 1024

Query: 137  GSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLA----QTTEQQQETERSKEE 192
               +  D    +R   + ++E+ K R +L  +   L + +A    Q  E + +  + +EE
Sbjct: 1025 HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084

Query: 193  AEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEE 252
             + A+++ ++E  Q+    +   +K  +LE ++ ++Q D++S +      ++  +   EE
Sbjct: 1085 LQAALARVEEEAAQK----NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140

Query: 253  LQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAK 312
            L+ L+ +L++   L+  AA++         +L+ + EQ   + ++  +E      E K  
Sbjct: 1141 LEALKTELEDT--LDSTAAQQ---------ELRSKREQEVNILKKTLEE------EAKTH 1183

Query: 313  EEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEA---SK 369
            E ++ +MR    K ++  E++ ++L  T+  KA +E+ K+TL+N+   L  EV+     K
Sbjct: 1184 EAQIQEMRQ---KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240

Query: 370  KQAELDRKAMDELLRERDI-LNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA 428
              +E  RK ++  L+E  +  N+          K T L    +    N+ G +     ++
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL----QVELDNVTGLLSQSDSKS 1296

Query: 429  QKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEI---KLK 485
             K  K    LE +         +  ++ L     +K  E +   +R+++ E E     L+
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356

Query: 486  QQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHL 545
            +Q     A  +D     ++ V   +   ++KRKL+  +  + +  E+   K +A  KL  
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE---KVAAYDKLEK 1413

Query: 546  EQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQ 605
             + R+++E + L  +L   RQ A          E +++K  +++AE      +  +E D+
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNL-------EKKQKKFDQLLAEEKTISAKYAEERDR 1466

Query: 606  VISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE 665
              +E     ++ +     LA   E+   Q++ L +   Q+   +ED+   + ++ K   E
Sbjct: 1467 AEAEAREKETKAL----SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522

Query: 666  KGILARSMAN-VEELRQEFFHMQREL-------LKERTRCRALEEELENPLNVHRWRKLE 717
                 R++   VEE++ +   ++ EL       L+     +A++ + E  L      + E
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ----GRDE 1578

Query: 718  ASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHV-----LARQPGPE 772
             S+    +L++++  ++  L    +E  ++ + +  ++KL M+LK +      A +   E
Sbjct: 1579 QSEEKKKQLVRQVREMEAEL---EDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635

Query: 773  AAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKR- 831
            A +QL+  +  + D  ++L    +       Q+KE + +++ +  E+  L+++  A +R 
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695

Query: 832  KEQLQKNKD 840
            K Q Q+ +D
Sbjct: 1696 KRQAQQERD 1704



 Score =  118 bits (295), Expect = 3e-26
 Identities = 192/954 (20%), Positives = 408/954 (42%), Gaps = 134/954 (14%)

Query: 3    EEKGGKQVLEESAFEEMERDFQ-GVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLM 61
            E++  K   E+   E+   +F   +  E    KSL K + ++E +   +++    E++  
Sbjct: 984  EDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR 1043

Query: 62   AKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDK-EQKAKETI 120
             +  +   ++  +S  ++  +    + Q  IA LK ++ K  + + +A  + E++A +  
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIA---ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100

Query: 121  LALKEEIVNLTKLVEQGSGLSMD---QHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLA 177
            +ALK+    + +L  Q S L  D   + ++     + K ++ +E + L +E+    +S A
Sbjct: 1101 MALKK----IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA 1156

Query: 178  QTTEQQQETERS--------KEEAEHAISQFQQEIQQRQNEASREF--------RKKEKL 221
               E + + E+         +EEA+   +Q Q E++Q+ ++A  E         R K  L
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEEAKTHEAQIQ-EMRQKHSQAVEELAEQLEQTKRVKANL 1215

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRN 281
            EK  + ++ +      E+K L Q    S+ + +K+E QL+E ++      +   +   + 
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275

Query: 282  AKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTE 341
             KLQ E +  + +  Q   ++ +   +  A E ++   +  + + N+ +  +  KL   E
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335

Query: 342  DQK-------AEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNML 394
            D+K        E E+ K  L+ QI  L  +V   KK+ E     ++     +  L K++ 
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395

Query: 395  KAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKER---DRYINQASD 451
                  +++       E+ K  L+ E+ +   +   QR+   +LEK++   D+ + +   
Sbjct: 1396 GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKT 1455

Query: 452  LTQKVLMNME----DIKVRETQIFDYRKKI-------AESEIKLKQQQNLYEAVRSDRNL 500
            ++ K     +    + + +ET+     + +       AE E   KQ +   E + S ++ 
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDD 1515

Query: 501  YSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAE 560
              K++ E +     ++++++ M  Q++EL++++ A E A ++L +  Q ++ + E    +
Sbjct: 1516 VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER---D 1572

Query: 561  LQKLRQQALETKHFIEKQ------EAEERKLLRIIAEADGERLRQ------------KKE 602
            LQ   +Q+ E K  + +Q      E E+ +  R +A A  ++L               K 
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632

Query: 603  LDQVISERDILGSQL---VRRNDELALLYEKIKIQ----QSVLNKGESQYNQRLEDMRIL 655
             D+ I +   L +Q+   +R  D+     E+I  Q    +  L   E++  Q  E++   
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692

Query: 656  RLEIKKLRREKGILARSMAN------------------VEELRQEFFHMQ--RELLKERT 695
                ++ ++E+  LA  +AN                  + +L +E    Q   EL+ +R 
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752

Query: 696  RCRALE-EELENPLNVHR-----------------------WRKLEASDPNAYE-----L 726
            +   L+ +++   LN+ R                        +++E +  + Y+     L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812

Query: 727  IQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEA-AEQLKLYRRTLH 785
              KI  L+++L ++T+E   ++   ++  +   +LK VL +       AEQ   Y+    
Sbjct: 1813 EAKIAQLEEQLDNETKE---RQAACKQVRRTEKKLKDVLLQVDDERRNAEQ---YKDQAD 1866

Query: 786  DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +LK L  +L   E +++       KL  EL++  +   A  R+    KNK
Sbjct: 1867 KASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920



 Score =  107 bits (267), Expect = 5e-23
 Identities = 147/770 (19%), Positives = 326/770 (42%), Gaps = 99/770 (12%)

Query: 8    KQVLEESA------FEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLM 61
            K+ LEE A       +EM +     + EL+  + LE+ +     L    K++ +NE+  +
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELA--EQLEQTKRVKANLEKA-KQTLENERGEL 1229

Query: 62   A---------------KCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMV 106
            A               K +++ A++     K     ++  +    +  L+ E++    ++
Sbjct: 1230 ANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLL 1289

Query: 107  DSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLL----RFKEEVTKER 162
              +  K  K  +   AL+ ++ +  +L+++ +   +   + ++ +      F+E++ +E 
Sbjct: 1290 SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349

Query: 163  D---QLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKE 219
            +    L  ++  L   +A   ++ +++    E AE    + Q++++        +    +
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409

Query: 220  KLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQM 279
            KLEK   ++Q ++D    ++   +Q     +++ +K +Q L E+K ++ + A+E ++ + 
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469

Query: 280  RNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVH-QMRLDIGKLNKIREQIHKKLH 338
                  +E E  +L   +  +E    A+E KA+ E ++ Q R ++  L   ++ + K +H
Sbjct: 1470 E----AREKETKALSLARALEE----AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521

Query: 339  HTEDQKAEVEQHKETLKNQIVGLEREVEAS--------------KKQAELDRKAMDELLR 384
              E  K  +EQ  E +K Q+  LE E++A+              K Q E D +  DE   
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSE 1581

Query: 385  ERDILNKNMLKAVNAT----QKQTDLV----KLHEQAKRNLEGEIQNY---KDEAQKQRK 433
            E+       ++ + A     +KQ  +     K  E   ++LE  I +    +DEA KQ +
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641

Query: 434  IIFHLEKERDRYINQASDLTQKVLM----NMEDIKVRETQIFDYRKKIAESEIKLKQQQN 489
             +    K+  R ++      +++L     N + +K  E ++   ++++A +E   +Q Q 
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701

Query: 490  LYE---------------AVRSDRNLYSK------NLVEAQDEITDMKRKLKIMIHQVDE 528
              +               A+   R L ++       L E Q     +  +LK    Q+D+
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQ 1761

Query: 529  LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRI 588
            +  D++ + S   K    +Q++E++ + LK +LQ++  +      +     A E K+ ++
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEM--EGTVKSKYKASITALEAKIAQL 1819

Query: 589  IAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQR 648
              + D E   ++    QV      L   L++ +DE     E+ K Q    +    Q  ++
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNA-EQYKDQADKASTRLKQLKRQ 1878

Query: 649  LEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            LE+        ++ +R      +    +E+  +    M RE+   + + R
Sbjct: 1879 LEEAE------EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 52/253 (20%), Positives = 110/253 (43%), Gaps = 38/253 (15%)

Query: 33   DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTI 92
            +K L+    E  +L   +  +   +++   +  EL  EI  +S K A AL+  +  +  I
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731

Query: 93   ASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLL 152
            A L++E+E+     +   D+ +KA   I  +  ++ NL +   Q +  +  Q       L
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDL-NLERSHAQKNENARQQLERQNKEL 1790

Query: 153  RFK------------------------------EEVTKERDQLLSEV----VKLRESLAQ 178
            + K                              +  TKER     +V     KL++ L Q
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ 1850

Query: 179  TTEQQQETERSKEEAEHA---ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSR 235
              ++++  E+ K++A+ A   + Q ++++++ + EA R    + KL++EL+      D+ 
Sbjct: 1851 VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAM 1910

Query: 236  QTEIKALQQYVQK 248
              E+ +L+  +++
Sbjct: 1911 NREVSSLKNKLRR 1923


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  137 bits (345), Expect = 4e-32
 Identities = 212/998 (21%), Positives = 419/998 (41%), Gaps = 196/998 (19%)

Query: 9    QVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELN 68
            Q L E+  ++ E+D+   L E   ++S+ K  I+   LH         + RL A    L+
Sbjct: 305  QTLTENLLKK-EQDYTK-LEEKHNEESVSKKNIQ-ATLHQKDLDCQQLQSRLSASETSLH 361

Query: 69   AEIVVNSAKVATALKLSQD---DQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKE 125
               V  S K     KL ++    +T    LK E ++  +  +   +KEQ      L L+ 
Sbjct: 362  RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE---EKEQHG----LQLQS 414

Query: 126  EIVNL-TKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQ 184
            EI  L +KL+E    L  + H  +++  +   E   +++Q   +V  L+  L++  EQ +
Sbjct: 415  EINQLHSKLLETERQLG-EAHGRLKEQRQLSSEKLMDKEQ---QVADLQLKLSRLEEQLK 470

Query: 185  ETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQ 244
            E   +  E +H + + +Q+ Q++Q        K  + + +L+Q+   +  +  +I+ L+ 
Sbjct: 471  EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEA 530

Query: 245  YVQKSKEELQKLEQQLK-----------EQKILNERAAKE---LEQFQMRNAKLQQENEQ 290
             +QKSKE +  LE++ +           E  +LN+   K     EQ      KL+ ++E 
Sbjct: 531  LLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 590

Query: 291  HSLVCEQLSQENQQKALELKAKE---------------------EEVHQMRLDIG----- 324
            H    E L  + Q++   L+A +                     E+V Q+ + I      
Sbjct: 591  HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTEL 650

Query: 325  -------------------------------KLNKIR---EQIHKKLHHTEDQKAEVEQH 350
                                           +LNKI    +Q+  KL   ++  +++E H
Sbjct: 651  LLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESH 710

Query: 351  KETLKNQIVGLER-----------------EVEASKKQAELDRKAMDELLRERDILNKNM 393
             +  K + + LE+                 EV+ASK+QA  D +   +L  + ++    +
Sbjct: 711  LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATEL 770

Query: 394  LKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT 453
             K +   ++     +L  Q K      I+    + +++++I+    K+    ++Q + + 
Sbjct: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL----KQDFETLSQETKIQ 826

Query: 454  QKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQ--NLYEAVRSDRNLYSKNLVEAQDE 511
             + L N     V E Q     K+   +E+   + +   + +++++ ++ + K   + +  
Sbjct: 827  HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886

Query: 512  ITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET---LKAELQKLRQQA 568
            I D+++  K + HQ+    E+   ++  L K       +EKEKE    LK EL  +++Q 
Sbjct: 887  ILDLEKTCKELKHQLQVQMENTLKEQKELKK------SLEKEKEASHQLKLELNSMQEQL 940

Query: 569  LETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDI-----------LGSQL 617
            ++ ++ +++ E EE++L   I E      ++KK+++ +  E  I           L  QL
Sbjct: 941  IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000

Query: 618  VRRNDELALLYEKIKIQQSVLNKGESQYNQ-------RLEDMRILRLEIKKLRREKGILA 670
             +   ELA   EKI + Q+   K +  + Q       R  ++   R ++K +  +  +  
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060

Query: 671  RSMAN-----------VEELRQEFFHMQRELLKE----RTRCRAL-----EEELENPLNV 710
              + +           ++EL+     ++++  K+    + RC+AL     E+ L+    V
Sbjct: 1061 EDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELV 1120

Query: 711  HRWRKLEASDPNAYELIQKIHTLQKRLIS-KTEEVVE-------KELLLQEKEKLYMELK 762
            +   KL   +       ++I  L + L S K E + E       K+LL+Q+K +L  +  
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180

Query: 763  HVLARQPGPEAAEQLKLYRRTLHDK----KQQLKV--------LSSELNMYEVQSKEYKY 810
             + A      A EQ K  ++ L D+    +++LK         L SE+   EV  K+++ 
Sbjct: 1181 SLKA------AVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234

Query: 811  EVEKLTNELQNL--------KKKYLAQKRKEQLQKNKD 840
               KLT ++  L        K+   +Q+R  +L+K  D
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272



 Score =  124 bits (312), Expect = 3e-28
 Identities = 186/877 (21%), Positives = 387/877 (44%), Gaps = 115/877 (13%)

Query: 8   KQVLEESAFEEMERDFQGVLHELSGD-KSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRE 66
           K++ +    ++ E    G++ + S + +SLE+   E +  +  +K+  D  ++   K  +
Sbjct: 111 KELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQ---KAAQ 167

Query: 67  LNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDK--EQKAKETILALK 124
           L  EI    +K      L +  +  +  L +E+ K   ++     +  ++   E +  LK
Sbjct: 168 LATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK 227

Query: 125 EEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE---VVKLRESLAQTTE 181
           +E+V +  L++    +++++    R+  + K+E  K + Q  S    + +LR  LA+  +
Sbjct: 228 KELVQVQTLMDN---MTLERE---RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ 281

Query: 182 QQ----QETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKE----LKQIQADMD 233
           +     QE ++ K      ++Q  Q + +   +  +++ K E+   E     K IQA + 
Sbjct: 282 EVAVYVQELQKLKSSVNE-LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340

Query: 234 SRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSL 293
            +  + + LQ  +  S+  L ++  +L E+    ++  +EL + + +   L+ E +Q   
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ--- 397

Query: 294 VCEQLSQENQQKALELKAKEEEVHQMRLDI--------GKLNKIREQIHKKLHHTEDQKA 345
             +Q  +E +Q  L+L+++  ++H   L+         G+L + R+   +KL   E Q A
Sbjct: 398 -LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVA 456

Query: 346 EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTD 405
           +++     L+ Q+   E+   +++ Q +LD+       +E+  L ++    +   + Q D
Sbjct: 457 DLQLKLSRLEEQLK--EKVTNSTELQHQLDKTKQQH--QEQQALQQSTTAKLR--EAQND 510

Query: 406 LVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKER-DRYIN-QASDLTQKVLMNMED- 462
           L ++  Q   + + +IQN +   QK ++ I  LEKER D Y   QA +    VL  +++ 
Sbjct: 511 LEQVLRQIG-DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569

Query: 463 ---IKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKL 519
              ++ + TQ+ +  K   +SE   + Q+NL++ V+  +     +L  AQD +  ++  +
Sbjct: 570 NHTLQEQVTQLTEKLKN--QSESHKQAQENLHDQVQEQK----AHLRAAQDRVLSLETSV 623

Query: 520 KIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQE 579
             +  Q++E KE +S          L+ Q   K +  L AE  K  Q+A    H    Q 
Sbjct: 624 NELNSQLNESKEKVS---------QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 674

Query: 580 A---EERKLLRIIAEADG--ERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEK 630
           A   ++++L +I  + D    +L+ K+E    L+  + E       L ++ +EL    +K
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK 734

Query: 631 IKIQQSVLNKGESQYNQRLEDMRILRLEI--------KKLRREKGILARSMANVEELRQE 682
           ++     +   + Q  Q L+  R L  ++        K+L  EK I++ +  ++++  + 
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794

Query: 683 FFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTE 742
              ++++L K+    + L+++ E    + +  K++       EL  +I T          
Sbjct: 795 LESIKQKLTKQEEEKQILKQDFET---LSQETKIQHE-----ELNNRIQTT--------- 837

Query: 743 EVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYE 802
            V E + +  EKE L  EL  V                +  L      LK   SE     
Sbjct: 838 -VTELQKVKMEKEALMTELSTV----------------KDKLSKVSDSLKNSKSEFEKEN 880

Query: 803 VQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
            + K    ++EK   EL++  +  +    KEQ +  K
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917



 Score =  114 bits (286), Expect = 3e-25
 Identities = 184/886 (20%), Positives = 374/886 (42%), Gaps = 162/886 (18%)

Query: 95  LKKEIEKAWKM----------VDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQ 144
           LKKE+EK   +          V  +  + Q  ++ +   + E  N+ ++ +     +   
Sbjct: 109 LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL 168

Query: 145 HSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQ--TTEQQQETERSKEEAEHAISQFQQ 202
            + I D+    +E    R+    +V +L E L +  T  Q  +TE  +      ++  ++
Sbjct: 169 ATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK 228

Query: 203 EIQQRQ----NEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEE------ 252
           E+ Q Q    N      R+ EKL+ E K++Q+   S +  I  L+  + K  +E      
Sbjct: 229 ELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ 288

Query: 253 -LQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALE--- 308
            LQKL+  + E    N+   + L + +    KL++++ + S+  + +     QK L+   
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ 348

Query: 309 ----LKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTE--------------DQKAEVEQH 350
               L A E  +H++ +++ +  +  +++ ++L   E               Q+ E EQH
Sbjct: 349 LQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408

Query: 351 KETLKNQIVGL-------------------EREVEASKKQAELDRKAMDELLRERDILNK 391
              L+++I  L                   E+   +S+K  + +++  D  L+   +  +
Sbjct: 409 GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 468

Query: 392 NMLKAVNATQKQTDLVKLHEQ-----------------AKRNLE----------GEIQNY 424
              K  N+T+ Q  L K  +Q                 A+ +LE           +IQN 
Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528

Query: 425 KDEAQKQRKIIFHLEKER-DRYIN-QASDLTQKVLMNMED----IKVRETQIFDYRKKIA 478
           +   QK ++ I  LEKER D Y   QA +    VL  +++    ++ + TQ+ +  K   
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN-- 586

Query: 479 ESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
           +SE   + Q+NL++ V+  +     +L  AQD +  ++  +  +  Q++E KE +S    
Sbjct: 587 QSESHKQAQENLHDQVQEQK----AHLRAAQDRVLSLETSVNELNSQLNESKEKVS---- 638

Query: 539 ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEA---EERKLLRIIAEAD-- 593
                 L+ Q   K +  L AE  K  Q+A    H    Q A   ++++L +I  + D  
Sbjct: 639 -----QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693

Query: 594 GERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRL 649
             +L+ K+E    L+  + E       L ++ +EL    +K++     +   + Q  Q L
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753

Query: 650 EDMRILRLEI--------KKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALE 701
           +  R L  ++        K+L  EK I++ +  ++++  +    ++++L K+    + L+
Sbjct: 754 QQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813

Query: 702 EELENPLNVHRWRKLEASD--PNAYELIQKIHTLQKRLISKTEEVVEK------------ 747
           ++ E      + +  E ++        +QK+   ++ L+++   V +K            
Sbjct: 814 QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK 873

Query: 748 ----------ELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSE 797
                     +  + + EK   ELKH L  Q      EQ +L +++L  +K+    L  E
Sbjct: 874 SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL-KKSLEKEKEASHQLKLE 932

Query: 798 LNMYEVQ-------SKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
           LN  + Q        K+ + E ++L   +  LK+   ++++K+Q++
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS--SEQKKKQIE 976



 Score =  112 bits (280), Expect = 1e-24
 Identities = 144/687 (20%), Positives = 291/687 (42%), Gaps = 94/687 (13%)

Query: 197 ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
           ++  +QE+Q  Q     E    E+L+KEL++ Q     +Q E K     V  S  ELQ L
Sbjct: 85  VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG---LQQQEAKP-DGLVTDSSAELQSL 140

Query: 257 EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
           EQQL+E +  N    +  + F+ + A+L  E      + +  S+ +++++L   A++   
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATE------IADIKSKYDEERSLREAAEQ--- 191

Query: 317 HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDR 376
                   K+ ++ E+++K+    +D K E+ Q          G+E +V   KK+    +
Sbjct: 192 --------KVTRLTEELNKEATVIQDLKTELLQRP--------GIE-DVAVLKKELVQVQ 234

Query: 377 KAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIF 436
             MD +  ER+            ++K  D  K  +    + E  I   + E  K  + + 
Sbjct: 235 TLMDNMTLERE----------RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284

Query: 437 HLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRS 496
              +E  +  +  ++LTQK     E++  +E       +K  E  +  K  Q        
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344

Query: 497 DRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKL-----HLEQQRIE 551
           D       L  ++  +  +  +L        +LKE++S  E+    L      L+QQR E
Sbjct: 345 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404

Query: 552 KEKE--TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKE------- 602
           KE+    L++E+ +L  + LET    E+Q  E    L+   +   E+L  K++       
Sbjct: 405 KEQHGLQLQSEINQLHSKLLET----ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460

Query: 603 ----LDQVISERDILGSQLVRRNDELALLY-EKIKIQQSVLNKGESQYNQRLEDMRILRL 657
               L++ + E+    ++L  + D+    + E+  +QQS   K     N   + +R +  
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520

Query: 658 EIKKLRREKGILARSMANVEELRQEFFHMQREL------------LKERT-----RCRAL 700
           + +K++  + +L +S  N+  L +E   +  ++            L+E+      +   L
Sbjct: 521 KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL 580

Query: 701 EEELENPLNVHRWRK-------------LEASDPNAYELIQKIHTLQKRLISKTEEVVEK 747
            E+L+N    H+  +             L A+      L   ++ L  +L    E+V + 
Sbjct: 581 TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQL 640

Query: 748 ELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKE 807
           ++ ++ K +L +  +     Q   +    L   +  L DK+Q+L  ++++L+    + ++
Sbjct: 641 DIQIKAKTELLLSAEAAKTAQRA-DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD 699

Query: 808 YKYEVEKLTNELQNLKKKYLAQKRKEQ 834
            +    +L + L+  K+KYL+ ++K +
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTE 726



 Score =  103 bits (256), Expect = 9e-22
 Identities = 121/627 (19%), Positives = 294/627 (46%), Gaps = 82/627 (13%)

Query: 30   LSGDKSLEKFRIEYERLHA---VMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQ 86
            LS ++  E+   + ++L A    +K S +   + + + R+LN ++ + + +++  L++ +
Sbjct: 719  LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778

Query: 87   DDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHS 146
            +    ++S + +++K  + ++S   K  K +E    LK++   L+    Q + +  ++ +
Sbjct: 779  E---IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS----QETKIQHEELN 831

Query: 147  N-IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQ----QQETERSKEEAEHAISQFQ 201
            N I+  +   ++V  E++ L++E+  +++ L++ ++     + E E+  ++ + AI   +
Sbjct: 832  NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLE 891

Query: 202  QEIQQRQNEASREFRKKEKLEKELK-----------QIQADMDSRQTEIKALQQYVQKSK 250
            +  ++ +++   +     K +KELK           Q++ +++S Q ++   Q  +++++
Sbjct: 892  KTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE 951

Query: 251  EELQKLEQQLKEQKILNERAAKELEQFQ--MRNAKLQQENEQHSLVCEQLSQENQQKALE 308
            +E Q+L+  + E K  +E+  K++E  Q  ++ A LQ+   ++     +L Q+  Q A E
Sbjct: 952  KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN-----KLQQQLTQAAQE 1006

Query: 309  LKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETL-------------- 354
            L A++E++  ++ +  K  +  +Q+    +  E +     Q  +++              
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066

Query: 355  KNQIVG---LEREVEASKKQAELDRKAMDELLRER-----DILNKNMLKAVNATQKQTDL 406
            +NQI     L +E++ +K   E D    ++ L+ER     DI  +  LK      +++ L
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126

Query: 407  VKLHEQAKRNLEGEIQNYKDEAQKQR----KIIFHLEKERDRYINQASDLTQKV--LMNM 460
             ++ E+ K   E EI    +E +  +    K I +L+  +   I Q  +L  K   L   
Sbjct: 1127 AEI-EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAA 1185

Query: 461  EDIKVRETQIFDYRKKIAESEIK---LKQQQNLYEAVRSDR-----------------NL 500
             + + R  QI   + K  E E+K   ++++  L+  ++                      
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245

Query: 501  YSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAE 560
             ++NL   + E    +R++  +  Q D+L+ +I+  E+ +     E++ + +     + E
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305

Query: 561  LQKLRQQALETKHFIEKQEAEERKLLR 587
            ++KL+ + LE +  ++   A  ++L R
Sbjct: 1306 IEKLQTKVLELQRKLDNTTAAVQELGR 1332



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 83/383 (21%), Positives = 166/383 (43%), Gaps = 85/383 (22%)

Query: 18   EMERDFQGVLHELSGDKSLEKFRIE-----YERLHAVMKKS----YDNEKRLMAKCRELN 68
            E+E   Q  L + + + + EK +I      YE+     K+     Y  E  L+A  ++L 
Sbjct: 991  ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050

Query: 69   A----------EIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKE 118
            +          +++ N  ++    KL Q+ +T  A+L+++  K          KEQ+ +E
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK----------KEQQLQE 1100

Query: 119  TILAL----KEEIVNLTKLVEQGSGLSMDQHSNIR---DLLRFKEEVTKERDQLLSEVVK 171
               AL    KE+ +   +LV + S L+  +    R   ++ +  EE+   + + + E+  
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-------FQQEIQQRQNEASREFRKKE-KLEK 223
            L+++     +Q+ E +   +  + A+ Q        + ++++ + E  +EF +KE KL  
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220

Query: 224  ELKQIQADMDSRQT-------EIKALQQYV-------QKSKEELQKLEQQLK-------- 261
            E+K+ +  M   +        +I AL + +       Q S+  + +LE+Q          
Sbjct: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280

Query: 262  ----------EQKILNERAAK---ELEQFQMRNAKLQQENEQHSLVCEQLSQENQQ---- 304
                      E++ L ER  K   E+E+ Q +  +LQ++ +  +   ++L +ENQ     
Sbjct: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340

Query: 305  --KALELKAKEEEVHQMRLDIGK 325
              +AL  K  E+   Q  +  GK
Sbjct: 1341 HTQALNRKWAEDNEVQNCMACGK 1363



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 77/358 (21%), Positives = 149/358 (41%), Gaps = 66/358 (18%)

Query: 1    MAEEKGGKQVLE------ESAFEEMERDFQGVLHELSGDKS-----LEKFRIEYERLHAV 49
            +A EK    VL+      +  F++++ DF G   EL   +       EK  +  E L + 
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS- 1065

Query: 50   MKKSYDNEKRLMAKCRELNAEIVVNSAKVATAL----KLSQDDQTTIASLKKEIEKAWKM 105
             +    N+ +L+ + +   A +  +SAK    L    K  QD Q   +  +KE+      
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125

Query: 106  VDSAYDKEQKAKETILALKEE-----------IVNLT---------KLVEQGSGLSM--- 142
            +    + + + ++ I  L EE           I NL          KL  QG   S+   
Sbjct: 1126 LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAA 1185

Query: 143  -DQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQ-- 199
             +Q    + +L  K++V KE ++L  E ++    L    ++++   +  EE E  ++   
Sbjct: 1186 VEQEKRNQQIL--KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243

Query: 200  ---------FQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSK 250
                      ++E Q  Q   S   ++ + L  E+  ++A + + Q E +AL +   K +
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303

Query: 251  EELQKLEQQLKE------------QKILNERAAKELEQFQMRNAKLQQENE-QHSLVC 295
             E++KL+ ++ E            Q++  E  + +++  Q  N K  ++NE Q+ + C
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMAC 1361


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  137 bits (344), Expect = 6e-32
 Identities = 194/925 (20%), Positives = 398/925 (43%), Gaps = 103/925 (11%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVL-HELSGDKSLEKFRIEYE----RLHAVMKKSYD 55
            + E++  K + E+   E+   +    L  E    K+L K R + E     L   +KK   
Sbjct: 989  LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048

Query: 56   NEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQK 115
              + L    R+L+ E      ++A       + +  +A  ++E++ A    D     +  
Sbjct: 1049 TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNN 1108

Query: 116  AKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRES 175
            A + +  L+ +I  L +  E             RDL    E +  E +  L      +E 
Sbjct: 1109 ALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL 1168

Query: 176  LAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF--------RKKEKLEKELKQ 227
              +  ++  E +++ EE         Q+++QR   A  E         R K  LEK  + 
Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG 1228

Query: 228  IQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQE 287
            ++ D      E+K LQQ   +S+ + +KL+ Q++E         +   +   + +KLQ E
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE 1288

Query: 288  NEQHSLVCEQLSQENQQKALELKAKEEEVH--------QMRLDIGKLNKIREQIHKKLHH 339
             +  S + E+  ++  + A +  + E ++         + R  +   ++IR Q+ ++ + 
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR-QLEEEKNS 1347

Query: 340  TEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNA 399
             ++Q+ E E+ ++ L+ Q++ L+ ++  +KK+ + D   ++ L   +    K +LK   A
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK----KKLLKDAEA 1403

Query: 400  TQKQTDLVKLH----EQAKRNLEGEIQNYKDEAQKQRKIIFHLEKER---DRYINQASDL 452
              ++ +   L     E+ K  L+ E+ +   +   QR++  +LEK++   D+ + +   +
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 453  TQKVLMNME----DIKVRETQIFDYRKKIAES-------EIKLKQQQNLYEAVRSDRNLY 501
            + +     +    + + +ET+     + + E+       E + KQ +   E + S ++  
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523

Query: 502  SKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAEL 561
             KN+ E +     ++++++ M  Q++EL++++ A E A ++L +  Q ++ + E    +L
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER---DL 1580

Query: 562  QKLRQQALETKHFIEKQ------EAEERKLLRIIAEADGERLR-QKKELDQVISERDILG 614
            Q   +Q  E K  + KQ      E E+ +  R +A A  +++    K+L+  I   +   
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640

Query: 615  SQLVRRNDELALLYEKIKIQQSVLNKGES-------QYNQRLEDMRILRLEIKKLRREKG 667
             ++++   +L  L  ++K  Q  L +  +       Q  +  + ++ L  EI +L+ E  
Sbjct: 1641 DEVIK---QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697

Query: 668  ILARSMANVEELRQEFFHM-------QRELLKERTRCRA----LEEELENP-----LNVH 711
               R+  + E+ R E           +  LL E+ R  A    LEEELE       L   
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757

Query: 712  RWRK--LEASDPNAY-----ELIQKIHTLQKRLISKTEEVVEK--ELLLQEKEKLYMELK 762
            R+RK  L+    NA         QK    +++L  + +E+  K  EL    K K    + 
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817

Query: 763  HVLAR---------QPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVE 813
             + A+         Q   E A   KL RRT    +++LK +  ++      + +YK ++E
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRT----EKKLKEIFMQVEDERRHADQYKEQME 1873

Query: 814  KLTNELQNLKKKYLAQKRKEQLQKN 838
            K    ++ LK++ L +  +E  + N
Sbjct: 1874 KANARMKQLKRQ-LEEAEEEATRAN 1897



 Score =  135 bits (340), Expect = 2e-31
 Identities = 166/862 (19%), Positives = 365/862 (42%), Gaps = 65/862 (7%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            KQ   E   EEMER  Q +L E +     E+ + E E    +  ++ +   RL AK +EL
Sbjct: 867  KQTKVEGELEEMERKHQQLLEEKN--ILAEQLQAETE----LFAEAEEMRARLAAKKQEL 920

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
              EI+ +   + + ++  ++    + + KK+++   + ++   D+E+ A++ +   K   
Sbjct: 921  E-EILHD---LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTA 976

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
                K +E+   L  DQ+S             KE+  +   + +    LA+  E+ +   
Sbjct: 977  EAKIKKMEEEILLLEDQNSKF----------IKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026

Query: 188  RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
            + + + E  IS  ++ +++ +       + K KL+ E   +Q  +   Q +I  L+  + 
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086

Query: 248  KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            K +EELQ    +  ++ +    A K + + Q + A+LQ++ E       +  ++ +  + 
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146

Query: 308  ELKAKEEEVH--------QMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIV 359
            EL+A + E+         Q  L   +  ++ E        T++ +A+++  ++     + 
Sbjct: 1147 ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALE 1206

Query: 360  GLEREVEASKK-QAELDRKAMD------ELLRERDILNKNMLKAVNATQK-QTDLVKLH- 410
             L  ++E +K+ +A L++          EL  E  +L +   ++ +  +K    + +LH 
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHA 1266

Query: 411  -----EQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKV 465
                 ++ +  L  +    ++E      ++   EK+  ++   A+ L  ++    E ++ 
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326

Query: 466  RETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQ 525
               Q  +   +I + E +    Q   E     R    K ++  Q ++ D K+K+   +  
Sbjct: 1327 ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT 1386

Query: 526  VDELKE-------DISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ 578
            ++ L+E       D  A    L +  L   ++EK K  L+ EL  L       +      
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNL 1446

Query: 579  EAEERKLLRIIAEADGERLRQKKELDQVISE---RDILGSQLVRRNDELALLYEKIKIQQ 635
            E +++K  +++AE      R  +E D+  +E   ++     L R  +E     E+ + Q 
Sbjct: 1447 EKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506

Query: 636  SVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSM-ANVEELRQEFFHMQRELLKER 694
              L           +D+     E++K +R        M   +EEL  E    +   L+  
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566

Query: 695  TRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEK 754
               +A++ + E  L        E ++     LI+++  L+  L    +E  ++ L +  K
Sbjct: 1567 VNMQAMKAQFERDLQTRD----EQNEEKKRLLIKQVRELEAEL---EDERKQRALAVASK 1619

Query: 755  EKLYMELKHV-----LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            +K+ ++LK +      A +   E  +QL+  +  + D +++L+   +  +    QSKE +
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE 1679

Query: 810  YEVEKLTNELQNLKKKYLAQKR 831
             +++ L  E+  L+++  + +R
Sbjct: 1680 KKLKSLEAEILQLQEELASSER 1701



 Score =  129 bits (323), Expect = 2e-29
 Identities = 193/844 (22%), Positives = 364/844 (43%), Gaps = 121/844 (14%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E+  ++M +     L ELS  + LE+ +    R  A ++K   N++ L    +EL  E+ 
Sbjct: 1191 EAQIQDMRQRHATALEELS--EQLEQAK----RFKANLEK---NKQGLETDNKELACEV- 1240

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTK 132
                KV   +K   + +     L  ++++    V        +  E    L+ E+ N++ 
Sbjct: 1241 ----KVLQQVKAESEHKRK--KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294

Query: 133  LVEQGS--GLSMDQ-----HSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            L+E+    G+   +      S ++D     +E T+++  L S + +L E      EQQ+E
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 186  TERSKEEAEHAISQFQQEIQQRQN---------EASREFRKK------------------ 218
             E +++  E  +   Q ++   +          E+  E +KK                  
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414

Query: 219  -EKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF 277
             +KLEK   ++Q ++D    ++   +Q     +++ +K +Q L E+K ++ R A+E ++ 
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474

Query: 278  QMRNAKLQQENEQHSLVCEQLSQENQQKALELKAK-EEEVHQMRLDIGKLNKIREQIHKK 336
            +       +E E  +L   +  +E    ALE K + E +  Q+R D+  L   ++ + K 
Sbjct: 1475 EAE----AREKETKALSLARALEE----ALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526

Query: 337  LHHTEDQKAEVEQHKETLKNQIVGLEREVEA---SKKQAELDRKAMDELLRERDILNKNM 393
            +H  E  K  +EQ  E ++ Q+  LE E++A   +K + E++ +AM     ERD+  ++ 
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF-ERDLQTRD- 1584

Query: 394  LKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT 453
                   +K+  L+K   + +  LE E +        ++K+   L K+ +  I  A+   
Sbjct: 1585 ---EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL-KDLEAQIEAANKAR 1640

Query: 454  QKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYS--KNLVEAQDE 511
             +V+  +  +   + Q+ DY++++ E+  +  + +   ++  S++ L S    +++ Q+E
Sbjct: 1641 DEVIKQLRKL---QAQMKDYQRELEEA--RASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695

Query: 512  ITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALET 571
            +   +R  +    + DEL ++I+   S    L  E++R+E     L+ EL++  Q  +E 
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEE-EQSNMEL 1754

Query: 572  KHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDEL-ALLYE- 629
             +  ++      ++  + AE   ER   +K         D    QL R+N EL A L E 
Sbjct: 1755 LN--DRFRKTTLQVDTLNAELAAERSAAQKS--------DNARQQLERQNKELKAKLQEL 1804

Query: 630  ------KIKIQQSVLNKGESQYNQRLEDMRILRLEIKKL-RREKGILARSMANVEELRQE 682
                  K K   S L     Q  ++LE     R    KL RR +  L      VE+ R+ 
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864

Query: 683  FFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTE 742
                + ++ K   R + L+ +LE         + EA+  NA         LQ+ L   TE
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEE-------AEEEATRANASR-----RKLQRELDDATE 1912

Query: 743  EVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYE 802
                 E L +E   L   L     R+ GP +    +  RR LH     L+  S EL+  +
Sbjct: 1913 ---ANEGLSREVSTLKNRL-----RRGGPISFSSSRSGRRQLH-----LEGASLELSDDD 1959

Query: 803  VQSK 806
             +SK
Sbjct: 1960 TESK 1963



 Score =  116 bits (291), Expect = 8e-26
 Identities = 142/711 (19%), Positives = 328/711 (46%), Gaps = 69/711 (9%)

Query: 157  EVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQE--IQQRQNEASRE 214
            +VT++ ++L ++     E L +  E+Q + E   EE E    Q  +E  I   Q +A  E
Sbjct: 846  QVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901

Query: 215  -FRKKEKL-------EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKIL 266
             F + E++       ++EL++I  D++SR  E +   Q +Q  K+++Q   Q L+EQ   
Sbjct: 902  LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961

Query: 267  NERAAKELEQFQM-RNAKLQQENEQHSLVCEQLSQENQQKAL----------ELKAKEEE 315
             E A ++L+  ++   AK+++  E+  L+ +Q S+  ++K L          +L  +EE+
Sbjct: 962  EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021

Query: 316  VHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELD 375
               +     K   +   + ++L   E  + E+E+ K  L  +   L+ ++  ++ QA++D
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI--AELQAQID 1079

Query: 376  RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII 435
               + +L ++ + L   + +  + T  + + +K+     R L+ +I   +++ + ++   
Sbjct: 1080 ELKL-QLAKKEEELQGALARGDDETLHKNNALKV----VRELQAQIAELQEDFESEK--- 1131

Query: 436  FHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD-YRKKIAESEIKLKQQQNLYEAV 494
                  R++   Q  DL+       E+++  +T++ D      A+ E++ K++Q + E  
Sbjct: 1132 ----ASRNKAEKQKRDLS-------EELEALKTELEDTLDTTAAQQELRTKREQEVAEL- 1179

Query: 495  RSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEK 554
               +    +     + +I DM+++    +   +EL E +   +     L   +Q +E + 
Sbjct: 1180 ---KKALEEETKNHEAQIQDMRQRHATAL---EELSEQLEQAKRFKANLEKNKQGLETDN 1233

Query: 555  ETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILG 614
            + L  E++ L+Q   E++H  +K +A+ ++L   ++E D  R+   ++  ++ +E D + 
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293

Query: 615  SQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMA 674
            + L     +     +     +S L   +    +       L   I++L  EK  L     
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353

Query: 675  NVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQ 734
              EE R+   ++++++L  +++    ++++++ L       +E+ +    +L++    L 
Sbjct: 1354 EEEEARK---NLEKQVLALQSQLADTKKKVDDDLGT-----IESLEEAKKKLLKDAEALS 1405

Query: 735  KRLISKT----EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQ 790
            +RL  K     +    K  L QE + L ++L H   RQ      ++ K + + L ++K  
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH--QRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 791  LKVLSSELNMYEVQSKEYKYEVEKLTNELQN-LKKKYLAQKRKEQLQKNKD 840
                + E +  E +++E + +   L   L+  L+ K   +++ +QL+ + +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1584 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1699

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2054

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2175 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2285 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2394 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2421



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1853 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1907

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2024

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2085 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2141 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2253

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2254 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2308 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2352

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2353 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2407

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2408 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2435

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2436 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2476

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2593

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2594 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1253 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1363

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1541 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1718

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1834

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 2012

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2066



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2344 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2394

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2511

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2512 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1122

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1123 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1181

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1182 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1468

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1469 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1641

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1748 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1799

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1800 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1830



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2444

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2445 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2490

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2583

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2584 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2622

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2683 ARREDVRHYLQG 2694



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 694  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 746

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 747  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 806

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 807  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 866

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 867  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 926

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 927  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 986

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 987  SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1034

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1155 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1194

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1195 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1249 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1285


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1587

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1588 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1703

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1823

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1883

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1884 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1943

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2058

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2179 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2289 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2337

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2338 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2398 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2425



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1857 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1911

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1972 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2028

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2089 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2145 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2201 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2257

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2258 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2312 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2356

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2357 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2411

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2412 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2439

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2440 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2480

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2541 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2597

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2598 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2633



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1257 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1367

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1368 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1427

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1484

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1545 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1604

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1605 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1664

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1665 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1722

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1782

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1783 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1838

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 2016

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2070



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2112

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2227

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2348 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2398

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2399 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2515

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2516 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2569 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2607



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1126

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1127 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1185

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1186 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1233

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1472

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1473 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1586

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1645

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1696

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1752 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1803

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1804 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1834



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2401

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2448

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2449 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2494

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2587

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2588 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2626

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2627 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2686

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2687 ARREDVRHYLQG 2698



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 638  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 697

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 698  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 750

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 751  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 810

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 811  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 870

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 871  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 930

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 931  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 990

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 991  SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1038

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1159 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1198

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1199 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1252

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1253 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1289


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1584 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1699

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1879

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1880 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1939

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2054

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2175 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2285 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2333

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2334 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2394 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2421



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1853 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1907

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1968 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2024

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2085 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2141 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2253

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2254 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2308 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2352

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2353 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2407

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2408 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2435

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2436 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2476

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2593

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2594 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2629



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1253 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1363

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1480

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1541 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1600

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1601 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1661 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1718

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1778

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1779 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1834

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 2012

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2066



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2344 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2394

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2395 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2511

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2512 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2565 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2603



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1122

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1123 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1181

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1182 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1468

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1469 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1641

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1748 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1799

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1800 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1830



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2444

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2445 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2490

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2583

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2584 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2622

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2623 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2682

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2683 ARREDVRHYLQG 2694



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 693

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 694  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 746

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 747  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 806

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 807  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 866

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 867  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 926

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 927  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 986

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 987  SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1034

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1155 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1194

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1195 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1249 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1285


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1492 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1551

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1552 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1667

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1787

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1847

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1848 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1907

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2022

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2143 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2253 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2301

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2302 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2362 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2389



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1821 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1875

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1936 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 1992

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2053 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2109 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2165 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2221

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2222 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2276 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2320

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2321 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2375

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2376 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2403

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2404 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2444

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2505 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2561

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2562 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2597



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1221 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1331

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1332 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1391

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1448

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1509 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1568

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1569 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1628

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1629 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1686

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1746

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1747 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1802

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 1980

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2034



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2076

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2191

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2312 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2362

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2363 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2479

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2480 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2533 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2571



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1090

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1091 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1149

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1150 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1197

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1198 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1257

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1436

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1437 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1491 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1550

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1609

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1660

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1716 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1767

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1768 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1798



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2365

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2412

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2413 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2458

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2551

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2552 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2590

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2591 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2650

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2651 ARREDVRHYLQG 2662



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 602  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 661

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 662  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 714

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 715  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 774

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 775  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 834

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 835  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 894

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 895  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 954

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 955  SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1002

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1123 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1162

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1163 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1216

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1217 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1253


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1661 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1720

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1721 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1836

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 2016

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 2017 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 2076

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2191

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2312 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2422 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2470

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2471 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2531 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2558



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1990 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 2044

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 2105 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2161

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2222 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2278 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2334 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2390

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2391 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2445 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2489

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2490 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2544

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2545 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2572

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2573 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2613

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2674 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2730

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2731 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2766



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1390 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1500

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1501 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1617

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1678 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1737

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1738 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1797

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1798 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1855

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1915

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1916 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1971

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 2149

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2203



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2245

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2360

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2481 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2531

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2532 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2648

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2649 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2702 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2740



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1259

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1260 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1318

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1319 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1366

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1367 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1426

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1605

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1606 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1660 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1719

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1778

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1829

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1885 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1936

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1937 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1967



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2534

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2581

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2582 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2627

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2720

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2721 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2759

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2760 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2819

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2820 ARREDVRHYLQG 2831



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 771  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 830

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 831  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 883

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 884  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 943

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 944  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 1003

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 1004 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 1063

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 1064 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 1123

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 1124 SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1171

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1292 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1331

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1332 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1385

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1386 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1422


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1502 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1561

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1562 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1677

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1797

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1857

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1858 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1917

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2032

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2153 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2263 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2311

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2312 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2372 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2399



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1831 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1885

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1946 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2002

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2063 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2119 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2231

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2232 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2286 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2330

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2331 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2385

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2386 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2413

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2414 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2454

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2515 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2571

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2572 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2607



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1231 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1341

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1342 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1401

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1458

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1519 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1578

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1579 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1638

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1639 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1696

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1756

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1812

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 1990

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 1991 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2044



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2086

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2201

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2322 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2372

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2373 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2489

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2490 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2543 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2581



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1100

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1101 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1159

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1160 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1207

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1208 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1267

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1446

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1447 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1619

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1670

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1726 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1777

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1778 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1808



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2316 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2375

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2376 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2422

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2423 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2468

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2561

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2562 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2600

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2601 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2660

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2661 ARREDVRHYLQG 2672



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 612  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 671

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 672  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 724

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 725  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 784

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 785  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 844

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 845  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 904

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 905  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 964

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 965  SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1012

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1133 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1172

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1173 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1226

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1227 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1263


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1510 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1569

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1570 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1685

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1805

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1865

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1866 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1925

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2040

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2161 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2271 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2319

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2320 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2380 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2407



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1839 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1893

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1954 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2010

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2071 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2127 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2239

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2240 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2294 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2338

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2339 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2393

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2394 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2421

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2422 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2462

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2523 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2579

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2580 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2615



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1239 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1349

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1350 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1409

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1466

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1527 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1586

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1587 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1646

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1647 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1704

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1764

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1765 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1820

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 1998

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 1999 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2052



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2094

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2209

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2330 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2380

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2381 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2497

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2498 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2551 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2589



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1108

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1109 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1167

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1168 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1215

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1216 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1275

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1454

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1455 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1509 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1568

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1627

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1678

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1734 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1785

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1786 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1816



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2324 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2383

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2384 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2430

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2431 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2476

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2569

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2570 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2608

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2609 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2668

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2669 ARREDVRHYLQG 2680



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 620  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 679

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 680  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 732

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 733  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 792

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 793  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 852

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 853  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 912

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 913  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 972

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 973  SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1020

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1140

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1141 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1180

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1181 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1234

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1235 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1271


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  134 bits (338), Expect = 3e-31
 Identities = 196/930 (21%), Positives = 386/930 (41%), Gaps = 134/930 (14%)

Query: 12   EESAFEEMERDFQGVLH-ELSGDKSLEKFR-IEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            E  A  E +R  Q +    L  +++  + R  E ER   V       ++   A+ +   A
Sbjct: 1551 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA 1610

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEK-AWKMVDSAYDKEQ----------KAKE 118
                 +A++  +L   Q++   +A L++E E+ A +  ++   +E+          KA E
Sbjct: 1611 SFAEKTAQLERSL---QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667

Query: 119  TI-LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFK--EEVTKERDQLLSEVVKLRES 175
             + L L+ E V   K + Q       + +      R K  E+  ++R+    E+ K R+ 
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ- 1726

Query: 176  LAQTTEQQ-----QETERSKEEAEHAISQ---FQQEIQQRQNEASREFRKKEKLEKELKQ 227
            LA+ T QQ     QE  R + E E    Q    ++E+ + Q EA+   +K+++LE EL +
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786

Query: 228  IQADM------------DSRQTEIKA--------------------LQQYVQKSKEELQK 255
            ++A+M            +SR T  K+                    L+   +++K + Q 
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1846

Query: 256  LEQQLKEQKILNERAAKELEQFQMRNAKLQQENE----QHSLVCEQLSQENQQKALELKA 311
             E+    Q+   ER   E         +L+ E E    +     E+L +  + +A + + 
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR 1906

Query: 312  KEEEVHQMRLDI-GKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE---A 367
             EE+  Q + DI  +L ++R+    +L   +    +  + +  ++ +I+ L+   E   A
Sbjct: 1907 LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA 1966

Query: 368  SKKQAELD---------------RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
             K + EL+                +A  E  R+R +  +   +   A ++    +   E+
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026

Query: 413  AKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
            A R  +    E++  K + ++ R++    E+E  R +  A +  QK L   E     +  
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE-----KAH 2081

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE- 528
             F  ++K  E +  L+Q+Q++ + +R +     +   EA++     +R+      QV+E 
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141

Query: 529  --LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
              LK+    +  A  +     +++ KE E   A   +  Q AL  K   + +  + +K  
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201

Query: 587  RIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYE---KIKIQQSVLNKGES 643
                    + LRQK +++Q   E   L  QL   + +  LL E   ++K + +   +  S
Sbjct: 2202 E-------QTLRQKAQVEQ---ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251

Query: 644  QYNQRLEDMRILRLEIKKLR-----REKGILARSMANVEELRQEFFHMQRELLKERTRCR 698
            Q  + L  +R+   E+ KL+       + ++ R   N +   QE     +++ +E  R  
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311

Query: 699  ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV-------VEKELLL 751
               +E        R R+L   D     L Q+    +K L  K + V        E ELL 
Sbjct: 2312 VAAQE------AARLRQLAEED-----LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2360

Query: 752  QEKEKLYMELKHVL--ARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
            Q+KE    + + +     Q   + AE+ + ++RTL  ++Q+   +S+E    +++  E  
Sbjct: 2361 QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420

Query: 810  YEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
                +   + Q  +K+  A++  E+L + +
Sbjct: 2421 RAQARAEEDAQRFRKQ--AEEIGEKLHRTE 2448



 Score =  119 bits (298), Expect = 1e-26
 Identities = 188/876 (21%), Positives = 371/876 (42%), Gaps = 132/876 (15%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E A +E E + +  L  L+ D++ ++ R+E +   A   K+ D E+RL    +  ++E+ 
Sbjct: 1880 EIALKEKEAENER-LRRLAEDEAFQRRRLEEQ---AAQHKA-DIEERLAQLRKASDSELE 1934

Query: 73   VNSAKVATALKLSQDDQTTIASLKKEIEKAWK---MVDSAYDKEQKAKETILALKE---- 125
                 V   L+  +  +  I +LK   EKA      ++    + +   E  L  KE    
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994

Query: 126  EIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQE 185
            E     +L  +      +    ++  L  +EE  ++R   L EV +L+   A+  E ++ 
Sbjct: 1995 EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK---AKVEEARRL 2051

Query: 186  TERSKEEAEHAISQFQQEIQQR--QNEASREF---RKKEKLEKELKQIQADMDSRQTEIK 240
             ER+++E+   +   Q+  Q+R    E +  F   +K+++L++ L+Q Q+ +D  + E +
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111

Query: 241  ALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ 300
            A     +++ EE ++   Q + +   + R  +E E+ +    +  Q   Q     E+L +
Sbjct: 2112 A----ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167

Query: 301  ENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKL-HHTEDQKAEVEQHKETLKNQIV 359
            E +Q+A    A+  +  Q  L   +      + HKK    T  QKA+VEQ   TL+ Q+ 
Sbjct: 2168 EAEQEA----ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEG 419
              + +     ++ +  +    E  R+R  + + +    +   +  +L KL  + +     
Sbjct: 2224 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF---SVRVQMEELSKLKARIEAENRA 2280

Query: 420  EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
             I   KD  Q+       L++E ++    A +  +  +   E  ++R+    D  ++ A 
Sbjct: 2281 LILRDKDNTQR------FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334

Query: 480  SEIKLKQQ-QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
            +E  LK++ Q + EA R          ++A+ E+   +++L     Q   L+ED   KE 
Sbjct: 2335 AEKMLKEKMQAVQEATR----------LKAEAELLQQQKELAQ--EQARRLQED---KEQ 2379

Query: 539  ALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLR 598
               +L  E Q  ++   TL+AE Q+  + + E +    K    E    +  AE D +R R
Sbjct: 2380 MAQQLAEETQGFQR---TLEAERQRQLEMSAEAERL--KLRVAEMSRAQARAEEDAQRFR 2434

Query: 599  QKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE 658
            ++ E          +G +L R   ELA   EK+ + Q+                    LE
Sbjct: 2435 KQAEE---------IGEKLHRT--ELAT-QEKVTLVQT--------------------LE 2462

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
            I++ + +         + E LR+    ++RE           +E+L+    + + +  E 
Sbjct: 2463 IQRQQSDH--------DAERLREAIAELERE-----------KEKLQQEAKLLQLKSEEM 2503

Query: 719  SDPNAYELIQKIHTLQKRLISKTEEVVEKELLL-QEKEKL----------YMELKHVLAR 767
                  +L+Q+   LQ+  +S+ + ++++E  + QEK KL            +L+    R
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563

Query: 768  QPGPEAAEQLKLY------RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQN 821
            Q      E+ +L       RR  H+ ++ ++    EL   E Q ++   + E L  E Q 
Sbjct: 2564 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ---QEELLAEENQR 2620

Query: 822  LKK--KYLAQKRKEQLQKNKDTAPMDNTFLMVKPNG 855
            L++  + L ++ +  L  +++            PNG
Sbjct: 2621 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNG 2656



 Score =  108 bits (270), Expect = 2e-23
 Identities = 173/838 (20%), Positives = 351/838 (41%), Gaps = 144/838 (17%)

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKL---------------VEQGS 138
            +L +EIE+  + V+     ++ AK+ I A+K+  + L                  V+ GS
Sbjct: 1280 ALLEEIERHGEKVEEC---QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336

Query: 139  GLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAIS 198
               + ++ ++R        +T +  + +SE ++  E   +  EQQ+  ER +      ++
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER------LA 1390

Query: 199  QFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS----RQTEIKALQQYVQKSKEELQ 254
            + +  +++++  A    + K + E+E K++Q  M      R+      QQ  +  +EELQ
Sbjct: 1391 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1450

Query: 255  KLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ-----ENQQKALEL 309
            +L Q  + +     R A+  E+ ++R   +++E     L  E   +     E + +AL  
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLR---IEEEIRVVRLQLEATERQRGGAEGELQALRA 1507

Query: 310  KAKE---------EEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVG 360
            +A+E         EE  ++R  +   ++ + Q   +L      +AE  + K+     +  
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567

Query: 361  LE---REVEASKKQAELDRK-----AMDELLR--ERDILNKNMLKAVNATQKQTDL---- 406
            L     E E   +QAE++R      A++   R  E ++ +K    A    Q +  L    
Sbjct: 1568 LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEH 1627

Query: 407  ---VKLHEQAKRNL--EGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT-QKVLMNM 460
                +L E+A+R    + E +  ++EA+++ +       E  R   QA ++  QK L   
Sbjct: 1628 VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1687

Query: 461  EDIKVRETQIFDYRKK------------IAESEIKLKQQQNLYEAVRSDRNLYSKNLVEA 508
            E  K +E    + R++            +AE E  L++Q+ L E     R    + L+  
Sbjct: 1688 EAEKQKEEAEREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELIRL 1745

Query: 509  QDEITDMKRKLKIMIHQVDELKEDISAK-------ESALVKLHLEQQRI----------- 550
            + E    +++ +++  ++  L+ + +A        E+ L K+  E + +           
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEES 1805

Query: 551  ----EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
                EK K+ L+AE  + R+ A E      +  AEE K  R +AE D    RQ+ E ++V
Sbjct: 1806 RSTSEKSKQRLEAEAGRFRELAEEAARL--RALAEEAKRQRQLAEEDA--ARQRAEAERV 1861

Query: 607  ISER--------------DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED- 651
            ++E+              +I   +    N+ L  L E    Q+  L +  +Q+   +E+ 
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921

Query: 652  -MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL------ 704
              ++ +    +L R+KG++  ++    ++ +E   ++    K       LE EL      
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981

Query: 705  ---------ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
                     +  L   R R+L A +       ++   +QK L ++ E   +++  L+E E
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEE--RVQKSLAAEEEAARQRKAALEEVE 2039

Query: 756  KLYMELKHV--LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            +L  +++    L  +   E+A QL+L +     + Q       + + + VQ KE + +
Sbjct: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQ----AEEKAHAFAVQQKEQELQ 2093



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 127/579 (21%), Positives = 247/579 (42%), Gaps = 93/579 (16%)

Query: 2    AEEKGGKQVLE--ESAFEEMERDFQGVLHELSGD--------KSLEKFRIEYERLHAVMK 51
            AEEK     ++  E   ++  +  Q VL +L G+        +  E+ R++ ER  A  +
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2135

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            +  +  +RL     E         A      K ++ +    A  ++   +  +  D+  +
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195

Query: 112  KEQKAKETILALK----EEIVNLTKLVEQGSGLSMDQHSNIRD--LLRFKEEVT---KER 162
            K +K  E  L  K    +E+  L   +E+      D   N+ D  L R K E T   ++R
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEE-----TDHQKNLLDEELQRLKAEATEAARQR 2250

Query: 163  DQLLSEVVKLRESLAQTTEQ-----------------------QQETERSKEEAEHA--I 197
             Q+  E+  +R  + + ++                        Q+E E+ K+ AE A  +
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310

Query: 198  SQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE 257
            S   QE  + +  A  +  ++  L +++ + +       T +KA  + +Q+ KE  Q+  
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370

Query: 258  QQLKEQKILNERAAKEL-EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++L+E K   E+ A++L E+ Q     L+ E ++      QL    + + L+L+  E   
Sbjct: 2371 RRLQEDK---EQMAQQLAEETQGFQRTLEAERQR------QLEMSAEAERLKLRVAEMSR 2421

Query: 317  HQMRL--DIGKLNKIREQIHKKLHHTE--------------DQKAEVEQHKETLKNQIVG 360
             Q R   D  +  K  E+I +KLH TE               Q+ + +   E L+  I  
Sbjct: 2422 AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481

Query: 361  LEREVEASKKQA--------ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQ 412
            LERE E  +++A        E+     ++LL+E   L ++ L   ++  ++   +   EQ
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI---EQ 2538

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             K  LE   Q ++DE  K ++    L +E+ R   Q     Q+++ +ME+ + R+ +  +
Sbjct: 2539 EKAKLE---QLFQDEVAKAQQ----LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591

Query: 473  YRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
              ++  E   +L+QQ+   E + ++ N   +  ++  +E
Sbjct: 2592 GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEE 2630



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 164/812 (20%), Positives = 336/812 (41%), Gaps = 94/812 (11%)

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
            + + R L+A  +     ++  ++ +Q  +  + + ++++++A           Q    T+
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA-----------QAVPATL 1149

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSE----VVKLRESL 176
              L+    +L KL  Q           +RD LR  +EV +   Q   E    V + RE +
Sbjct: 1150 PELEATKASLKKLRAQAEA-QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERV 1208

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQ-NEASREFRKKEKLEKELKQIQADMDSR 235
            AQ  E+ Q                Q +++QR+  +  R+ R   +    L     D   R
Sbjct: 1209 AQLLERWQAV------------LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1256

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQF--QMRNAKLQQENEQHSL 293
            Q +I+A+     ++  E  + EQ L E+   +    +E ++F  Q  NA    E +  + 
Sbjct: 1257 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1316

Query: 294  VCEQLSQENQQKALELKAKEEEVHQMRLDI----GKLNKIREQ----IHKKLHHTEDQKA 345
              +     +  K  ++++  E V Q  +D+     +L  +  Q    I + L   E+++ 
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 346  EVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLK--------AV 397
              EQ +   + ++  +E  +E  ++ AE   +A  +  RE   L + M +        AV
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +A Q++  + +  +Q +++ E EIQ    +A+   +    +E+E  R +    + T++  
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE-IRVVRLQLEATERQR 1495

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEI----- 512
               E       ++   R +  E+E + +Q Q   E +R      S+   +A+ E+     
Sbjct: 1496 GGAEG------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549

Query: 513  --TDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR-----IEKEKETLKAELQKLR 565
               +  R+ +  +  ++EL+      E  L +  +E+ R     +E  + + +AELQ  R
Sbjct: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609

Query: 566  QQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV--ISERDILGSQLVRRNDE 623
                E    +E+   EE   +  + E    R +Q+ E ++    +ER++   QL + N+ 
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL-KANEA 1668

Query: 624  LALLYEKIKI-QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            L L  +  ++ QQ  L + E++  +          E ++  R +G          EL ++
Sbjct: 1669 LRLRLQAEEVAQQKSLAQAEAEKQKE---------EAEREARRRGKAEEQAVRQRELAEQ 1719

Query: 683  FFHMQRELLKERTRCR-ALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKT 741
                QR+L +   + R A E+EL     +    + E  +     L +++  LQ+   + T
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQEL-----IRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774

Query: 742  EEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMY 801
            ++  E E    E  K+  E++ +LA +   E        R T    KQ+L+  +      
Sbjct: 1775 QKRQELE---AELAKVRAEMEVLLASKARAEEES-----RSTSEKSKQRLEAEAGRFREL 1826

Query: 802  EVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
              ++   +   E+   + Q L ++  A++R E
Sbjct: 1827 AEEAARLRALAEEAKRQRQ-LAEEDAARQRAE 1857



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 88/432 (20%), Positives = 178/432 (41%), Gaps = 88/432 (20%)

Query: 1    MAEEKGGK-QVLEESAFEEMERDFQGVLHELSGDKS--------LEKFRIEYERLHAVMK 51
            +A+E+  + Q  +E   +++  + QG    L  ++          E+ ++    +     
Sbjct: 2365 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2424

Query: 52   KSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
            ++ ++ +R   +  E+  ++  +  ++AT     Q+  T + +L  EI++      S +D
Sbjct: 2425 RAEEDAQRFRKQAEEIGEKL--HRTELAT-----QEKVTLVQTL--EIQRQ----QSDHD 2471

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
             E+        L+E I  L +  E+     + Q + +  L + +E  T +++QLL E   
Sbjct: 2472 AER--------LREAIAELEREKEK-----LQQEAKLLQL-KSEEMQTVQQEQLLQETQA 2517

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQ-FQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            L++S     +   + ER  E+ +  + Q FQ E+ + Q     + R+++++E+E +++ A
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             M+  +      ++ V++ +EELQ+LEQQ ++Q                           
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ--------------------------- 2610

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
                 E+L  E  Q+  E                +L  + EQ    L H+E+  A     
Sbjct: 2611 -----EELLAEENQRLRE----------------QLQLLEEQHRAALAHSEEVTASQVAA 2649

Query: 351  KETLKN---QIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLV 407
             +TL N    + G   E E       L RK   + L+E  IL+   L+ +       D +
Sbjct: 2650 TKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDEL 2709

Query: 408  KLHEQAKRNLEG 419
               E  +  L+G
Sbjct: 2710 ARREDVRHYLQG 2721



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 126/698 (18%), Positives = 274/698 (39%), Gaps = 129/698 (18%)

Query: 222  EKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE-------L 274
            EKE +++  D   R T + A ++       EL+  E+++KE +   +R  +E       +
Sbjct: 661  EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 720

Query: 275  EQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIH 334
            E FQ   A LQ +      +C  +    ++ A    A  +    +R   G+L K++E + 
Sbjct: 721  ESFQ---AALQTQWSWMLQLCCCIEAHLKENA----AYFQFFSDVREAEGQLQKLQEALR 773

Query: 335  KK--------LHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            +K        +   ED   + +  KE L      L    + +K   +L  +     +R R
Sbjct: 774  RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 833

Query: 387  -DILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEA-------------QKQR 432
              +L     K V  T  + D  +L   A+ +    + +   EA             Q+ +
Sbjct: 834  LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 893

Query: 433  KIIFHLEKERDRYINQASDL--TQKVLMNMEDIK-----VRETQIFDYRK-KIAESEIKL 484
            + +  LE +    +     L    K L+  + ++     +R   +  +R  K  E    L
Sbjct: 894  EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQAL 953

Query: 485  KQQQNLYEAVRSDR---------------------NLYSKNLVEAQDEITDMKRKLKIMI 523
               +  Y+A   D                      + + + L+++ ++    + + +  I
Sbjct: 954  HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCI 1013

Query: 524  HQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             ++ +++  + A E+  V     + R+  +KE  +   Q++ +Q        +K +AE  
Sbjct: 1014 SELKDIRLQLEACETRTV----HRLRLPLDKEPARECAQRIAEQ--------QKAQAEVE 1061

Query: 584  KLLRIIA--EADGERLRQKKE----LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
             L + +A   A+ E++    E       + SE ++   +L +     A+  EK+K    V
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121

Query: 638  LNKGES------QYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL- 690
            +   +        + ++L++ + +   + +L   K  L +  A  E  +  F  ++ EL 
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181

Query: 691  ----LKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE 746
                + ER + R  E ++E    V RWR+  A      +L+++   +          + +
Sbjct: 1182 GAQEVGERLQQRHGERDVE----VERWRERVA------QLLERWQAV----------LAQ 1221

Query: 747  KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL--------SSEL 798
             ++  +E E+L  +L++        E+A+ L  + +    +++Q++ +          +L
Sbjct: 1222 TDVRQRELEQLGRQLRYY------RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1275

Query: 799  NMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
               +   +E +   EK+  E Q   K+Y+   +  +LQ
Sbjct: 1276 RQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYELQ 1312


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  134 bits (336), Expect = 5e-31
 Identities = 210/989 (21%), Positives = 404/989 (40%), Gaps = 181/989 (18%)

Query: 13   ESAFEEMERDFQGVLHE-----LSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            E+  +E+E     +L E     L      E      ER   ++K     E ++      L
Sbjct: 871  EARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERL 930

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKET-ILALKEE 126
              E  +NS  VA    L    +   +SLK++I+   ++  +  +KE+ A E  +  L EE
Sbjct: 931  EEEEEMNSELVAKKRNL----EDKCSSLKRDIDDL-ELTLTKVEKEKHATENKVKNLSEE 985

Query: 127  IV----NLTKLVEQGSGLSMDQHSNIRDLLRFKEE----VTKERDQLLSEVVKLRESLAQ 178
            +     N++KL ++   L  + H    D L+ +E+    + K   +L  +   L  SL Q
Sbjct: 986  MTALEENISKLTKEKKSLQ-EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQ 1044

Query: 179  TTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTE 238
              + + + ER+K + E  +   Q+ I   +N+  +   K +K E EL Q+QA +D  Q  
Sbjct: 1045 EKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVH 1104

Query: 239  IKALQQYVQKSKEELQKLEQQLKEQ-----KILNERA--AKELE---------------- 275
                Q+ +++ +  +++LE++++ +     KI  +R+  A+ELE                
Sbjct: 1105 SLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQ 1164

Query: 276  ---------QFQMRNAKLQQENEQHSLVCEQLSQENQQKALEL---------------KA 311
                     +FQ     L++   QH      L ++      EL               K 
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKE 1224

Query: 312  KEE---EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVE-------------------- 348
            K E   E+  M  +I  L+K +  I +     EDQ +E++                    
Sbjct: 1225 KSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARL 1284

Query: 349  -----------QHKETLKNQIV----GLEREVEASKKQAELDRKAMD------------- 380
                       + KE+L +Q+      L +++E  K+Q E + KA +             
Sbjct: 1285 QTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDC 1344

Query: 381  ELLRE-------------RDILNKNMLKAVNATQKQTDLVKLH---EQAKRNLEGEIQNY 424
            +LLRE             R +   N   A   T+ +TD ++     E+AK+ L   +Q  
Sbjct: 1345 DLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1404

Query: 425  KDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL 484
            ++  +        LEK + R   +  DL + +  +       + +  ++ K +AE + KL
Sbjct: 1405 EENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKL 1464

Query: 485  KQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLH 544
             + Q   EA + +    S  L + ++   ++  +L+ +  +   L+E+IS     + +  
Sbjct: 1465 DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETG 1524

Query: 545  LEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAE----ERKLLRIIAEADGERLRQK 600
               Q  EK K+ ++ E   L+    E +  +E +E++    + +L ++ +E D + + + 
Sbjct: 1525 KNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKD 1584

Query: 601  KELDQVISE--------RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQY----NQR 648
            +E++Q+           + +L +++  RND L L     K  +  LN+ E Q      Q 
Sbjct: 1585 EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK----KKMEGDLNEMEIQLGHSNRQM 1640

Query: 649  LEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRE---LLKERTRCRALEEELE 705
             E  + LR    +L+  +  L  ++ + E+L+++   ++R    LL+E    +   E+ E
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTE 1700

Query: 706  NPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEV--------VEKELLLQEKEKL 757
                +     L+ASD      +Q +H+    LI+  +++         E E  +QE    
Sbjct: 1701 RTRRLSEQELLDASD-----RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNA 1755

Query: 758  YMELKHVLARQPGPEAAEQLKL-------YRRTLHDKKQQLKVLSSELNMYE-VQSKEYK 809
              + K  +        AE+LK          R   + +Q +K L   L+  E +  K  K
Sbjct: 1756 EEKAKKAIT--DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813

Query: 810  YEVEKLTNELQNLKKKY-LAQKRKEQLQK 837
             +++KL N ++ L+ +  + QKR  +  K
Sbjct: 1814 KQIQKLENRVRELENELDVEQKRGAEALK 1842



 Score =  121 bits (304), Expect = 2e-27
 Identities = 180/834 (21%), Positives = 363/834 (43%), Gaps = 136/834 (16%)

Query: 77   KVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
            K+   LK S + +  +A++K++ E+  + +  +  + ++ +E +++L +E  +L   V+ 
Sbjct: 839  KIKPLLK-SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQS 897

Query: 137  GSGLSMDQHSNIRDLLRFK-------EEVT---KERDQLLSEVVKLRESLAQTTEQQQ-- 184
             +   MD       L++ K       +E+T   +E +++ SE+V  + +L       +  
Sbjct: 898  ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957

Query: 185  ---------ETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSR 235
                     + E+ K   E+ +    +E+   +   S+  ++K+ L++  +Q   D+   
Sbjct: 958  IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILN---ERAAKELEQFQMRNAKLQQENEQHS 292
            + ++  L +   K +++   LE  L+++K L    ERA ++LE     + K+ QE+    
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE----GDLKMSQES---- 1069

Query: 293  LVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKE 352
                 L  + QQ   +LK KE E+ Q++  I       EQ+H           + ++  +
Sbjct: 1070 --IMDLENDKQQIEEKLKKKEFELSQLQAKIDD-----EQVH---------SLQFQKKIK 1113

Query: 353  TLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHE- 411
             L+ +I  LE E+EA         K   +L RE + +++ + +A  AT  Q ++ K  E 
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173

Query: 412  ---QAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRY--INQASDLTQKVLMNMEDIKVR 466
               + +R+LE     ++  A   RK      K+ D    + +  D  Q+V   +E     
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRK------KQADSVAELGEQIDNLQRVKQKLE----- 1222

Query: 467  ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQV 526
                    K+ +E ++++    +  EA+   ++   +     +D+ +++K K      Q 
Sbjct: 1223 --------KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK----DEQQ 1270

Query: 527  DELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLL 586
             +L  D++ +++ L   + E     +EKE+L ++L K +Q   +    +++Q  EE K  
Sbjct: 1271 TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAK 1330

Query: 587  RIIAEA------DGERLRQKKELDQVISERDILGSQLVRRNDELA---LLYEKIKIQQS- 636
              +A A      D + LR++ E +Q    +  L   L + N E+A     YE   IQ++ 
Sbjct: 1331 NAMAHALQSSRHDCDLLREQYEEEQ--EAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388

Query: 637  VLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTR 696
             L + + +  QRL++        +         A      + L+ E   + R+L +  T 
Sbjct: 1389 ELEEAKKKLAQRLQEAE------ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442

Query: 697  CRALEEELENPLNV-HRWR--------KLEASDP-------------NAY-ELIQKIHT- 732
            C  L+++  N   V   W+        +LEA+               NAY E++ ++ T 
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502

Query: 733  ------LQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHD 786
                  LQ+ +   TE++ E    LQE EK        L  Q   +    L+    +L  
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEK-----TKKLVEQEKSDLQVALEEVEGSL-- 1555

Query: 787  KKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKD 840
            + ++ K+L  +L + +V+S+  +  +EK   E++ LK+   +Q+  E LQ   D
Sbjct: 1556 EHEESKILRVQLELSQVKSELDRKVIEK-DEEIEQLKRN--SQRAAEALQSVLD 1606



 Score =  101 bits (252), Expect = 3e-21
 Identities = 167/831 (20%), Positives = 344/831 (41%), Gaps = 108/831 (12%)

Query: 13   ESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIV 72
            E+ F++M RD             LE+  +++E   A ++K   +    + +  +    + 
Sbjct: 1172 EAEFQKMRRD-------------LEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVK 1218

Query: 73   VNSAKVATALKLSQDDQTT----IASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIV 128
                K  + LK+  DD  +    ++  K  IE+  + V+  +  E KAK+         +
Sbjct: 1219 QKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFS-EIKAKDEQQTQLIHDL 1277

Query: 129  NLTK--LVEQGSGLSM---DQHSNIRDLLRFKEEVTKERDQL---LSEVVKLRESLAQTT 180
            N+ K  L  Q   LS    ++ S I  L + K+ +T++ ++L   + E  K + ++A   
Sbjct: 1278 NMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHAL 1337

Query: 181  -----------EQQQETERSKEEAEHAISQFQQEIQQ-RQNEASREFRKKEKLEKELKQI 228
                       EQ +E + +K E + A+S+   E+ Q R    +   ++ E+LE+  K++
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397

Query: 229  QADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQEN 288
                  R  E +   +        L+K +Q+L+ +    E   ++LE+     A L ++ 
Sbjct: 1398 A----QRLQEAEENTETANSKCASLEKTKQRLQGEV---EDLMRDLERSHTACATLDKKQ 1450

Query: 289  EQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVE 348
                 V  +  Q+  +   EL+A ++E   +  ++ K+    E++  +L     +   ++
Sbjct: 1451 RNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQ 1510

Query: 349  QHKETLKNQIVGLER---EVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTD 405
            +    L  QI    +   E E +KK  E ++  +   L E +   ++    +   Q +  
Sbjct: 1511 EEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELS 1570

Query: 406  LVKLHEQAKR-NLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIK 464
             VK     K    + EI+  K  +Q+  + +  +     R  N A  L +K+     D+ 
Sbjct: 1571 QVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM---EGDLN 1627

Query: 465  VRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIH 524
              E Q+    +++AE++  L+  Q   +    D  L+  + + + +   D+K +L I+  
Sbjct: 1628 EMEIQLGHSNRQMAETQKHLRTVQGQLK----DSQLHLDDALRSNE---DLKEQLAIV-- 1678

Query: 525  QVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERK 584
                       + + L+   LE+ ++  E+      L +  Q+ L+    ++   ++   
Sbjct: 1679 ----------ERRNGLLLEELEEMKVALEQTERTRRLSE--QELLDASDRVQLLHSQNTS 1726

Query: 585  LLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQ 644
            L+    + + +  + + E++  I E      +  +   + A++ E++K +Q         
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT------- 1779

Query: 645  YNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL 704
             +  LE M+      K L +    L   +   E+L  +    Q + L+ R R      EL
Sbjct: 1780 -SAHLERMK------KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVR------EL 1826

Query: 705  ENPLNVHRWRKLEA-SDPNAYELIQKIHTLQ----KRLISKTEEVVEKELLLQEKEKLYM 759
            EN L+V + R  EA    + YE   K  T Q     + I + +++V+K   LQ K K Y 
Sbjct: 1827 ENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDK---LQAKVKSYK 1883

Query: 760  ELKHVLARQPGPEAAEQLKLYRRTLHDKK---QQLKVLSSELNMYEVQSKE 807
                  A +   +A  QL   RR  H+ +   ++  +  S++N    +S++
Sbjct: 1884 R----QAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRD 1930



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 122/626 (19%), Positives = 272/626 (43%), Gaps = 102/626 (16%)

Query: 17   EEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSA 76
            +E + + Q  L + + + +  + + E + +    ++  + +K+L  + +E        ++
Sbjct: 1355 QEAKAELQRALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAEENTETANS 1413

Query: 77   KVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILA-----LKEEIVNLT 131
            K A+  K  Q  Q  +  L +++E++     +  DK+Q+  + +LA     L E    L 
Sbjct: 1414 KCASLEKTKQRLQGEVEDLMRDLERSHTAC-ATLDKKQRNFDKVLAEWKQKLDESQAELE 1472

Query: 132  KLVEQGSGLSMD---QHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETER 188
               ++   LS +     +   +++   E + +E   L  E+  L E +A+T +  QE E+
Sbjct: 1473 AAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532

Query: 189  SKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQK 248
            +K+  E   S  Q  +++ +     E  K  +++ EL Q+++++D +  E          
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE---------- 1582

Query: 249  SKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALE 308
              EE+++L++        ++RAA+ L+   + +A+++  N+                AL 
Sbjct: 1583 KDEEIEQLKRN-------SQRAAEALQS--VLDAEIRSRND----------------ALR 1617

Query: 309  LKAKEE-EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH-------KETLKNQIVG 360
            LK K E ++++M + +G  N+   +  K L   + Q  + + H        E LK Q+  
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677

Query: 361  LEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQ----KQTDLVKLHE----- 411
            +ER      ++ E  + A+++  R R +  + +L A +  Q    + T L+   +     
Sbjct: 1678 VERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEAD 1737

Query: 412  --QAKRNLEGEIQNYKDEAQKQRKIIF-----------------HLEKERDRYINQASDL 452
              Q +  +E  IQ  ++  +K +K I                  HLE+ +        DL
Sbjct: 1738 IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797

Query: 453  TQKVLMNMEDIKVR----ETQIFDYRKKIAESEIKLKQQQN---LYEAVRSDRNLYS--- 502
              + L   E + ++    + Q  + R +  E+E+ ++Q++    L  A + +R +     
Sbjct: 1798 QHR-LDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTY 1856

Query: 503  ------KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET 556
                  KN++  QD +  ++ K+K    Q +E +E  + + S   ++  E +   +  + 
Sbjct: 1857 QAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADI 1916

Query: 557  LKAELQKLRQQALETKHFIEKQEAEE 582
             ++++ KLR ++ +    +  Q+ EE
Sbjct: 1917 AESQVNKLRAKSRD----VGSQKMEE 1938


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  132 bits (331), Expect = 2e-30
 Identities = 184/922 (19%), Positives = 383/922 (41%), Gaps = 127/922 (13%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMA----- 62
            K    E     M+ +FQ +  EL+  KS  K +   E++  ++K+  D + ++ A     
Sbjct: 847  KSAETEKEMATMKEEFQKIKDELA--KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 63   -----KCRELNAEIVVNSAKVATALKLSQDDQTTIASL--------------KKEIEKAW 103
                 +C +L    +   AK+    + ++D++   A L              KK+I+   
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL- 963

Query: 104  KMVDSAYDKEQKAKET-ILALKEEIVNL----TKLVEQGSGLSMDQHSNIRDLLRFKEEV 158
            ++  +  +KE+ A E  +  L EE+  L     KL ++   L       + DL   +++V
Sbjct: 964  ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1023

Query: 159  ---TKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
               TK + +L  +V  L  SL Q  + + + ER+K + E  +   Q+ I   +NE  +  
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083

Query: 216  RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELE 275
             K +K E E+  +Q+ ++  Q     LQ+ +++ +  +++LE++++ ++    +A K+  
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ-- 1141

Query: 276  QFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHK 335
                  + L +E E+ S   E+       +    K +E E  +MR D+ +     E    
Sbjct: 1142 -----RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 336  KLHHTE-DQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNK--- 391
             L     D  AE       L  QI  L+R  +  +K+    +  +D+L    + ++K   
Sbjct: 1197 TLRKKHADSVAE-------LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249

Query: 392  NMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASD 451
            N+ K     + Q   +K  E+ ++ L  ++   +   Q +         E++  ++Q S 
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309

Query: 452  LTQKVLMNMEDIKVRETQIFDYRKKIA-------------------ESEIKLKQQQNLYE 492
              Q     +E++K +  +    +  +A                   E E K + Q+ L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 493  A---VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR 549
            A   V   R  Y  + ++  +E+ + K+KL   +   +E  E ++AK ++L         
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASL--------- 1420

Query: 550  IEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
             EK K+ L+ E++ L      T       + ++R   +I+AE   +      EL+    E
Sbjct: 1421 -EKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDM---------RILRLE-- 658
               LG++L +    +   YE+   Q   L +      Q + D+         RI  LE  
Sbjct: 1480 ARSLGTELFK----IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1535

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
             K++ +EK       A +EE      H + ++L+ +     ++ E++  +   +  +++ 
Sbjct: 1536 KKQVEQEK---CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-AEKDEEIDQ 1591

Query: 719  SDPNAYELIQKIH-TLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQL 777
               N   +++ +  TL   + S+ + +  K+ +  +  ++ ++L H         AAE L
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA-----NRMAAEAL 1646

Query: 778  KLYR-----------------RTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQ 820
            + YR                 R+  D K+QL ++    N+ + + +E +  +E+     +
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706

Query: 821  NLKKKYLAQKRKEQLQKNKDTA 842
              +++ L    + QL   ++T+
Sbjct: 1707 IAEQELLDASERVQLLHTQNTS 1728



 Score =  108 bits (269), Expect = 3e-23
 Identities = 149/841 (17%), Positives = 356/841 (42%), Gaps = 91/841 (10%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMA 62
            EE GG    +    ++ E +FQ +  +L      E+  +++E   A ++K + +    + 
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDL------EEATLQHEATAATLRKKHADSVAELG 1210

Query: 63   KCRELNAEIVVNSAKVATALKLSQDDQT----TIASLKKEIEKAWKMVDSAYD----KEQ 114
            +  +    +     K  + +K+  DD      T++  K  +EK  + ++        KE+
Sbjct: 1211 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEE 1270

Query: 115  KAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQL---LSEVVK 171
            + +  I  L  +   L     + S    ++ + +  L R K+  T++ ++L   L E +K
Sbjct: 1271 EQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330

Query: 172  LRESLAQTT-----------EQQQETERSKEEAEHAISQFQQEIQQ-RQNEASREFRKKE 219
             + +LA              EQ +E + SK E + A+S+   E+ Q R    +   ++ E
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390

Query: 220  KLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQM 279
            +LE+  K++   + + +  ++A+       ++  Q+L+ ++++  +       ++E+   
Sbjct: 1391 ELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML-------DVERTNA 1443

Query: 280  RNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHH 339
              A L ++      +  +  Q+ ++   EL+A ++E   +  ++ K+    E+   +L  
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503

Query: 340  TEDQKAEVEQHKETLKNQIV-GLER--EVEASKKQAELDRKAMDELLRERDILNKNMLKA 396
             + +   ++Q    L  QI  G +R  E+E  KKQ E ++  +   L E +   ++    
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 397  VNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKV 456
            +   Q + + VK   +  R +  + +      +   +I+  ++   D  I   +D  +  
Sbjct: 1564 ILRIQLELNQVK--SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621

Query: 457  LMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMK 516
                 D+   E Q+    +  AE+   L+  +N  + +  D  ++  + + +Q+   D+K
Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEA---LRNYRNT-QGILKDTQIHLDDALRSQE---DLK 1674

Query: 517  RKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIE 576
             +L ++  + + L+ +I    + L       ++ E+ ++  + EL       L+    ++
Sbjct: 1675 EQLAMVERRANLLQAEIEELRATL-------EQTERSRKIAEQEL-------LDASERVQ 1720

Query: 577  KQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQS 636
                +   L+    + + +  + + E++ ++ E      +  +   + A++ E++K +Q 
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780

Query: 637  V---LNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKE 693
                L + +    Q ++D+++   E ++L  + G                   ++++ K 
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGG-------------------KKQIQKL 1821

Query: 694  RTRCRALEEELEN--PLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLL 751
              R R LE E+E+    N    + L   +    EL  +    +K ++ + +++V+K   L
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNIL-RLQDLVDK---L 1877

Query: 752  QEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            Q K K Y         Q     A+  KL +  L + +++  +  S++N   V+S+E   +
Sbjct: 1878 QAKVKSYKRQAEEAEEQSNTNLAKFRKL-QHELEEAEERADIAESQVNKLRVKSREVHTK 1936

Query: 812  V 812
            V
Sbjct: 1937 V 1937



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 126/646 (19%), Positives = 293/646 (45%), Gaps = 87/646 (13%)

Query: 7    GKQVLEESAFEEMERDFQGVLHELSG-DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCR 65
            GKQ   +   EE++R  +  +   +    +L+  R + + L    ++  +++  L     
Sbjct: 1310 GKQAFTQQ-IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALS 1368

Query: 66   ELNAEIVVNSAKVAT-ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALK 124
            + N E+     K  T A++ +++ +     L + ++ A + V++   K    ++T   L+
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428

Query: 125  EEIVNLTKLVEQGSG----LSMDQHSNIRDLLRFKEEVT----------KERDQLLSEVV 170
             E+ +L   VE+ +     L   Q +  + L  +K++            KE   L +E+ 
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 171  KLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            K++ +  ++ +Q +  +R  +  +  IS   ++I +         + K+++E+E  ++QA
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             ++  +  ++  +  + + + EL +++ ++ ++KI  +   +E++Q +  + ++  E+ Q
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEV-DRKIAEKD--EEIDQLKRNHIRIV-ESMQ 1604

Query: 291  HSLVCEQLSQENQQKALELKAKEE-EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQ 349
             +L  E  S+ +   A+ LK K E ++++M + +   N++  +  +   +T+    + + 
Sbjct: 1605 STLDAEIRSRND---AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661

Query: 350  H-------KETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQ- 401
            H       +E LK Q+  +ER     + + E  R  +++  R R I  + +L A    Q 
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721

Query: 402  ---KQTDLVKLHEQAKRNL---EGEIQNYKDEA----QKQRKIIF-------HLEKERDR 444
               + T L+   ++ + ++   +GE+++   EA    +K +K I         L+KE+D 
Sbjct: 1722 LHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD- 1780

Query: 445  YINQASDLTQKVLMNME----DIKVR--------------ETQIFDYRKKIAESEIKLKQ 486
                 S   +++  NME    D+++R              + Q  + R +  E E++ +Q
Sbjct: 1781 ----TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836

Query: 487  QQNLYEAVRSDRN--------LYS-----KNLVEAQDEITDMKRKLKIMIHQVDELKEDI 533
            ++N  EAV+  R          Y      KN++  QD +  ++ K+K    Q +E +E  
Sbjct: 1837 KRNA-EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895

Query: 534  SAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQE 579
            +   +   KL  E +  E+  +  ++++ KLR ++ E    +  +E
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 75/309 (24%), Positives = 149/309 (48%), Gaps = 36/309 (11%)

Query: 541  VKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKL--------LRIIAEA 592
            +K  L+    EKE  T+K E QK++ +  +++   +++E EE+ +        L++  +A
Sbjct: 842  IKPLLKSAETEKEMATMKEEFQKIKDELAKSE--AKRKELEEKMVTLLKEKNDLQLQVQA 899

Query: 593  DGERLRQKKE-LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV-LNKGESQYNQRLE 650
            + E L   +E  DQ+I  +  L ++ ++   E A   E+I  + +    K E + ++  +
Sbjct: 900  EAEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 651  DMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNV 710
            D+  L L + K+ +EK      + N+ E          +L KE+   +AL+E  +  L+ 
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLD- 1014

Query: 711  HRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPG 770
                 L+A +        K++TL K  I   ++V + E  L++++KL M+L+    +  G
Sbjct: 1015 ----DLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1063

Query: 771  PEAAEQLKLYRRTLHDKKQQLKVLSSELNM--YEVQSKEYKYEVEKLTNELQNLKKKYLA 828
                  LKL + ++ D + + + L  +L    +E+ + + K E E+    +Q  KK    
Sbjct: 1064 -----DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG-IQLQKKIKEL 1117

Query: 829  QKRKEQLQK 837
            Q R E+L++
Sbjct: 1118 QARIEELEE 1126


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  132 bits (331), Expect = 2e-30
 Identities = 184/922 (19%), Positives = 383/922 (41%), Gaps = 127/922 (13%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMA----- 62
            K    E     M+ +FQ +  EL+  KS  K +   E++  ++K+  D + ++ A     
Sbjct: 847  KSAETEKEMATMKEEFQKIKDELA--KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904

Query: 63   -----KCRELNAEIVVNSAKVATALKLSQDDQTTIASL--------------KKEIEKAW 103
                 +C +L    +   AK+    + ++D++   A L              KK+I+   
Sbjct: 905  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL- 963

Query: 104  KMVDSAYDKEQKAKET-ILALKEEIVNL----TKLVEQGSGLSMDQHSNIRDLLRFKEEV 158
            ++  +  +KE+ A E  +  L EE+  L     KL ++   L       + DL   +++V
Sbjct: 964  ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1023

Query: 159  ---TKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREF 215
               TK + +L  +V  L  SL Q  + + + ER+K + E  +   Q+ I   +NE  +  
Sbjct: 1024 NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD 1083

Query: 216  RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELE 275
             K +K E E+  +Q+ ++  Q     LQ+ +++ +  +++LE++++ ++    +A K+  
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ-- 1141

Query: 276  QFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHK 335
                  + L +E E+ S   E+       +    K +E E  +MR D+ +     E    
Sbjct: 1142 -----RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196

Query: 336  KLHHTE-DQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNK--- 391
             L     D  AE       L  QI  L+R  +  +K+    +  +D+L    + ++K   
Sbjct: 1197 TLRKKHADSVAE-------LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249

Query: 392  NMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASD 451
            N+ K     + Q   +K  E+ ++ L  ++   +   Q +         E++  ++Q S 
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSR 1309

Query: 452  LTQKVLMNMEDIKVRETQIFDYRKKIA-------------------ESEIKLKQQQNLYE 492
              Q     +E++K +  +    +  +A                   E E K + Q+ L +
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSK 1369

Query: 493  A---VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQR 549
            A   V   R  Y  + ++  +E+ + K+KL   +   +E  E ++AK ++L         
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASL--------- 1420

Query: 550  IEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
             EK K+ L+ E++ L      T       + ++R   +I+AE   +      EL+    E
Sbjct: 1421 -EKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDM---------RILRLE-- 658
               LG++L +    +   YE+   Q   L +      Q + D+         RI  LE  
Sbjct: 1480 ARSLGTELFK----IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI 1535

Query: 659  IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA 718
             K++ +EK       A +EE      H + ++L+ +     ++ E++  +   +  +++ 
Sbjct: 1536 KKQVEQEK---CELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-AEKDEEIDQ 1591

Query: 719  SDPNAYELIQKIH-TLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQL 777
               N   +++ +  TL   + S+ + +  K+ +  +  ++ ++L H         AAE L
Sbjct: 1592 LKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA-----NRMAAEAL 1646

Query: 778  KLYR-----------------RTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQ 820
            + YR                 R+  D K+QL ++    N+ + + +E +  +E+     +
Sbjct: 1647 RNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706

Query: 821  NLKKKYLAQKRKEQLQKNKDTA 842
              +++ L    + QL   ++T+
Sbjct: 1707 IAEQELLDASERVQLLHTQNTS 1728



 Score =  108 bits (269), Expect = 3e-23
 Identities = 149/841 (17%), Positives = 356/841 (42%), Gaps = 91/841 (10%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMA 62
            EE GG    +    ++ E +FQ +  +L      E+  +++E   A ++K + +    + 
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDL------EEATLQHEATAATLRKKHADSVAELG 1210

Query: 63   KCRELNAEIVVNSAKVATALKLSQDDQT----TIASLKKEIEKAWKMVDSAYD----KEQ 114
            +  +    +     K  + +K+  DD      T++  K  +EK  + ++        KE+
Sbjct: 1211 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEE 1270

Query: 115  KAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQL---LSEVVK 171
            + +  I  L  +   L     + S    ++ + +  L R K+  T++ ++L   L E +K
Sbjct: 1271 EQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIK 1330

Query: 172  LRESLAQTT-----------EQQQETERSKEEAEHAISQFQQEIQQ-RQNEASREFRKKE 219
             + +LA              EQ +E + SK E + A+S+   E+ Q R    +   ++ E
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390

Query: 220  KLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQM 279
            +LE+  K++   + + +  ++A+       ++  Q+L+ ++++  +       ++E+   
Sbjct: 1391 ELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML-------DVERTNA 1443

Query: 280  RNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHH 339
              A L ++      +  +  Q+ ++   EL+A ++E   +  ++ K+    E+   +L  
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503

Query: 340  TEDQKAEVEQHKETLKNQIV-GLER--EVEASKKQAELDRKAMDELLRERDILNKNMLKA 396
             + +   ++Q    L  QI  G +R  E+E  KKQ E ++  +   L E +   ++    
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 397  VNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKV 456
            +   Q + + VK   +  R +  + +      +   +I+  ++   D  I   +D  +  
Sbjct: 1564 ILRIQLELNQVK--SEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLK 1621

Query: 457  LMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMK 516
                 D+   E Q+    +  AE+   L+  +N  + +  D  ++  + + +Q+   D+K
Sbjct: 1622 KKMEGDLNEMEIQLNHANRMAAEA---LRNYRNT-QGILKDTQIHLDDALRSQE---DLK 1674

Query: 517  RKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIE 576
             +L ++  + + L+ +I    + L       ++ E+ ++  + EL       L+    ++
Sbjct: 1675 EQLAMVERRANLLQAEIEELRATL-------EQTERSRKIAEQEL-------LDASERVQ 1720

Query: 577  KQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQS 636
                +   L+    + + +  + + E++ ++ E      +  +   + A++ E++K +Q 
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780

Query: 637  V---LNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKE 693
                L + +    Q ++D+++   E ++L  + G                   ++++ K 
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGG-------------------KKQIQKL 1821

Query: 694  RTRCRALEEELEN--PLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLL 751
              R R LE E+E+    N    + L   +    EL  +    +K ++ + +++V+K   L
Sbjct: 1822 EARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNIL-RLQDLVDK---L 1877

Query: 752  QEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE 811
            Q K K Y         Q     A+  KL +  L + +++  +  S++N   V+S+E   +
Sbjct: 1878 QAKVKSYKRQAEEAEEQSNTNLAKFRKL-QHELEEAEERADIAESQVNKLRVKSREVHTK 1936

Query: 812  V 812
            V
Sbjct: 1937 V 1937



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 126/646 (19%), Positives = 293/646 (45%), Gaps = 87/646 (13%)

Query: 7    GKQVLEESAFEEMERDFQGVLHELSG-DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCR 65
            GKQ   +   EE++R  +  +   +    +L+  R + + L    ++  +++  L     
Sbjct: 1310 GKQAFTQQ-IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALS 1368

Query: 66   ELNAEIVVNSAKVAT-ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALK 124
            + N E+     K  T A++ +++ +     L + ++ A + V++   K    ++T   L+
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428

Query: 125  EEIVNLTKLVEQGSG----LSMDQHSNIRDLLRFKEEVT----------KERDQLLSEVV 170
             E+ +L   VE+ +     L   Q +  + L  +K++            KE   L +E+ 
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 171  KLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            K++ +  ++ +Q +  +R  +  +  IS   ++I +         + K+++E+E  ++QA
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             ++  +  ++  +  + + + EL +++ ++ ++KI  +   +E++Q +  + ++  E+ Q
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEV-DRKIAEKD--EEIDQLKRNHIRIV-ESMQ 1604

Query: 291  HSLVCEQLSQENQQKALELKAKEE-EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQ 349
             +L  E  S+ +   A+ LK K E ++++M + +   N++  +  +   +T+    + + 
Sbjct: 1605 STLDAEIRSRND---AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661

Query: 350  H-------KETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQ- 401
            H       +E LK Q+  +ER     + + E  R  +++  R R I  + +L A    Q 
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721

Query: 402  ---KQTDLVKLHEQAKRNL---EGEIQNYKDEA----QKQRKIIF-------HLEKERDR 444
               + T L+   ++ + ++   +GE+++   EA    +K +K I         L+KE+D 
Sbjct: 1722 LHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD- 1780

Query: 445  YINQASDLTQKVLMNME----DIKVR--------------ETQIFDYRKKIAESEIKLKQ 486
                 S   +++  NME    D+++R              + Q  + R +  E E++ +Q
Sbjct: 1781 ----TSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQ 1836

Query: 487  QQNLYEAVRSDRN--------LYS-----KNLVEAQDEITDMKRKLKIMIHQVDELKEDI 533
            ++N  EAV+  R          Y      KN++  QD +  ++ K+K    Q +E +E  
Sbjct: 1837 KRNA-EAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895

Query: 534  SAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQE 579
            +   +   KL  E +  E+  +  ++++ KLR ++ E    +  +E
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 75/309 (24%), Positives = 149/309 (48%), Gaps = 36/309 (11%)

Query: 541  VKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKL--------LRIIAEA 592
            +K  L+    EKE  T+K E QK++ +  +++   +++E EE+ +        L++  +A
Sbjct: 842  IKPLLKSAETEKEMATMKEEFQKIKDELAKSE--AKRKELEEKMVTLLKEKNDLQLQVQA 899

Query: 593  DGERLRQKKE-LDQVISERDILGSQLVRRNDELALLYEKIKIQQSV-LNKGESQYNQRLE 650
            + E L   +E  DQ+I  +  L ++ ++   E A   E+I  + +    K E + ++  +
Sbjct: 900  EAEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSELKK 958

Query: 651  DMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNV 710
            D+  L L + K+ +EK      + N+ E          +L KE+   +AL+E  +  L+ 
Sbjct: 959  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK---KALQEAHQQTLD- 1014

Query: 711  HRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPG 770
                 L+A +        K++TL K  I   ++V + E  L++++KL M+L+    +  G
Sbjct: 1015 ----DLQAEE-------DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1063

Query: 771  PEAAEQLKLYRRTLHDKKQQLKVLSSELNM--YEVQSKEYKYEVEKLTNELQNLKKKYLA 828
                  LKL + ++ D + + + L  +L    +E+ + + K E E+    +Q  KK    
Sbjct: 1064 -----DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG-IQLQKKIKEL 1117

Query: 829  QKRKEQLQK 837
            Q R E+L++
Sbjct: 1118 QARIEELEE 1126


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  131 bits (330), Expect = 2e-30
 Identities = 196/924 (21%), Positives = 406/924 (43%), Gaps = 155/924 (16%)

Query: 13   ESAFEEMER-DFQGVLHELSGD-KSLEK-FRIEYERLHAVMKKSYDNEKRLMAKCRELNA 69
            ESAF   E  + +  + EL+   K +E   ++   +L A  K   D EK L +   E+  
Sbjct: 640  ESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITK 699

Query: 70   EIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVN 129
               +   KV   L  + + +  I  L+KE+           +KE +  E   AL+EE++ 
Sbjct: 700  LTSLIDGKVPKDLLCNLELEGKITDLQKEL-----------NKEVEENE---ALREEVIL 745

Query: 130  LTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVV--------------KLRES 175
            L++L    S +       I+D       +T E+D+L SEVV              K ++ 
Sbjct: 746  LSELKSLPSEVER-LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDD 804

Query: 176  LAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSR 235
            LA T    + T++  +  +     F+Q+ +    E  R  ++   L KE ++  + + + 
Sbjct: 805  LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL 864

Query: 236  QTEIK-ALQQYVQKSKE------ELQKLEQQL-----------KEQKILNERAAKELEQF 277
            +TE+    Q+  +K++E      E+++L++QL           +E+ ++ E+  + LE+ 
Sbjct: 865  KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924

Query: 278  Q---MRNAKLQQENEQHSLVCEQL-------------SQENQQKALE-LKAKEEEVHQMR 320
            +        L+Q  E   +  +QL             +QE  + ALE LK  +E ++ ++
Sbjct: 925  KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984

Query: 321  LDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAEL------ 374
                  +KI E++ + LH  E+      + K+  + ++VG++++ +   K  +       
Sbjct: 985  ------SKISEEVSRNLHMEEN----TGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK 1034

Query: 375  ------DRKAMDELLRERDILNKNMLKAVNATQKQ--TDLVKLHEQAKRNLEGEIQNYKD 426
                   ++ +  L++E++ L + ML++V A ++Q  TDL +  E    N E E++   D
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNEL-QQMLESVIAEKEQLKTDLKENIEMTIENQE-ELRLLGD 1092

Query: 427  EAQKQRKII-------FHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAE 479
            E +KQ++I+          E E  R  ++ +++ +K+    + ++ ++ Q+ + +++++E
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152

Query: 480  SEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESA 539
             + K+ + +NL   +++        L   + E  ++ +KL     +V    + I+ +   
Sbjct: 1153 MQKKINEIENLKNELKNK----ELTLEHMETERLELAQKLNENYEEV----KSITKERKV 1204

Query: 540  LVKLHLEQQRIEKEKETLKAELQKLRQQALETK--------HFIEKQE-------AEERK 584
            L +L   Q+  E E++ L+  ++++    L+TK        H  E QE       +   K
Sbjct: 1205 LKEL---QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261

Query: 585  LLRIIAEADGERLRQK--KELDQVISERDILG-----SQLVRRNDELALLYEKIKIQQS- 636
              +II   D E+   K  +E+  +  E+++L      S+     +EL LL E+   + S 
Sbjct: 1262 TAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1321

Query: 637  VLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANV--------EELRQEFFHMQR 688
             L + E +  +  E  +  + EIK L +E+  L      +        E +R+    +Q 
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1381

Query: 689  ELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVE-- 746
               K+       E++ E    V    + +  D     +  ++  L KRL    +E+    
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA 1441

Query: 747  ---------KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSE 797
                     +E+L  E ++L   +K ++A+    E  E+LK+    L ++++ +  L   
Sbjct: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKH--LETEEELKVAHCCLKEQEETINELRVN 1499

Query: 798  LNMYEVQSKEYKYEVEKLTNELQN 821
            L+  E +    + ++E + ++LQN
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQN 1523



 Score =  125 bits (313), Expect = 2e-28
 Identities = 173/877 (19%), Positives = 391/877 (44%), Gaps = 100/877 (11%)

Query: 37   EKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLK 96
            EKF+   E + ++ K+  DN K +       + ++  +  +    ++ SQ  Q    ++K
Sbjct: 1335 EKFQESQEEIKSLTKER-DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK 1393

Query: 97   KEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKE 156
            ++  +  K+V S  ++ +     +L ++ E++ L+K +++        H  ++ + + K+
Sbjct: 1394 EKDNETTKIV-SEMEQFKPKDSALLRIEIEMLGLSKRLQES-------HDEMKSVAKEKD 1445

Query: 157  EVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFR 216
            ++ + ++ L SE  +L+E++ +   +  ETE   + A   + + ++ I + +   S +  
Sbjct: 1446 DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKET 1505

Query: 217  KKEKLEKELKQIQADMDSRQTEI--KALQQYVQKSKEELQKLEQ--QLKEQKILNERAAK 272
            +   ++K+L+ I   + ++  EI  K  Q  +++  E  +K+ +  Q KE +   + A +
Sbjct: 1506 EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565

Query: 273  ELE--QFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIR 330
             +E    ++ N   + + E   ++ E+   +  Q+AL+++  + + +   + + K+ + +
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI-VAKMKESQ 1624

Query: 331  EQIHKKL-----HHTEDQKAEVEQHKETLKNQIVGLE-----------------REVEAS 368
            E+ ++ L     + T+++  E+E  KE  + Q + LE                  E+ + 
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684

Query: 369  KKQAELDRKAMDELLR-ERDILNKNMLKAVNA-TQKQTDL------VKLHEQAKRNLEGE 420
             K+ + D ++++E L+ ERD L +N+ + +    +KQ +L      +K H++    L G 
Sbjct: 1685 TKERD-DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743

Query: 421  IQNYKDEAQKQRKIIFHLE---KERDRYINQASDLTQKVLMNMED--------IKVRETQ 469
            +    +E    +K + H     K +D  I +   +    L   ++        +  +  +
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKR------------ 517
            + + +K +  S  KL+++    +A         K++ E Q ++++M++            
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863

Query: 518  -KLKI-MIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFI 575
             KL+I  ++   +L E++   +S +     E+  + + +ETLK E  +L++   ETK   
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVM----KERDNLRRVEETLKLERDQLKESLQETK-AR 1918

Query: 576  EKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQ 635
            + +  +E K  R++++   E +    +L + ISE+ I  S + +  D+     +K KIQ+
Sbjct: 1919 DLEIQQELKTARMLSKEHKETV---DKLREKISEKTIQISDIQKDLDKSKDELQK-KIQE 1974

Query: 636  SVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERT 695
              L K E Q  +  ED+ +   +I ++ + K        +++ +R + F + ++L +   
Sbjct: 1975 --LQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLE 2032

Query: 696  RCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
              R + +E +    +    K+E       + I  +  +  R     +   EK LL   ++
Sbjct: 2033 EIRIVAKERDELRRIKESLKMERD-----QFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087

Query: 756  KLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKL 815
             L   L+   +R       E LK Y   + D  + L  LS +L       KE +++ E  
Sbjct: 2088 HLTESLREKCSR-----IKELLKRYSE-MDDHYECLNRLSLDL------EKEIEFQKELS 2135

Query: 816  TNELQNLKKKYLAQKRKEQLQKNKDTAPMDNTFLMVK 852
                 NL   YL  K  E+L        M+   +M K
Sbjct: 2136 MRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK 2172



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 186/988 (18%), Positives = 401/988 (40%), Gaps = 164/988 (16%)

Query: 5    KGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDN---EKRLM 61
            K    V E S  E + + ++  + +L   K LE+  +E  R  A+ K        EK L+
Sbjct: 330  KNTPYVNEVSTDEALLKRYRKEIMDLK--KQLEEVSLE-TRAQAMEKDQLAQLLEEKDLL 386

Query: 62   AKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIE----KAWKMVDSAYDKEQKAK 117
             K +    E +      +++L L Q+ +   A  K+ +     K  KM +S Y  +    
Sbjct: 387  QKVQNEKIENLTRMLVTSSSLTLQQELK---AKRKRRVTWCLGKINKMKNSNYADQFNIP 443

Query: 118  ETILALKEEI-VNLTKLVEQGSGLSMDQHSNIRDLLRFKE--EVTK--ERDQLLSEVVKL 172
              I     ++ +NL + +++      D  SN  D L   E    TK   ++ + SE+  L
Sbjct: 444  TNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSL 503

Query: 173  RESLAQTTEQQQETERSKEEAEHAIS---------------------QFQQEIQQRQNEA 211
            R          ++    KEE E  +                      Q   EI   +N  
Sbjct: 504  RADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563

Query: 212  SREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSK---------------EELQKL 256
                   + LE EL      +  ++ +IK LQ+Y+   K               E+ +++
Sbjct: 564  KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623

Query: 257  EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQ--QKALELKAK-- 312
            +Q L + + +   A +E    +  N +L+++ ++ +   +Q+  + Q  Q  LE K K  
Sbjct: 624  KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683

Query: 313  ---EEEVHQMRLDI----------------------GKLNKIREQIHKKLHHTEDQKAEV 347
               E+E+     +I                      GK+  ++++++K++   E  + EV
Sbjct: 684  VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743

Query: 348  EQHKE--TLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTD 405
                E  +L +++  L +E++   ++  +     D+L  E       +   +    K  D
Sbjct: 744  ILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKD 803

Query: 406  LVKLHEQAKRNLEGEIQNYK--------------DEAQKQRKIIFHLEKERDRYINQASD 451
             +   +   ++ + E QN+K              +E ++  + I +L KE  ++ +    
Sbjct: 804  DLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863

Query: 452  LTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDE 511
            L  ++    ++++ +  ++ +   ++ + + +L+ + +  + V  ++ L ++ L +  +E
Sbjct: 864  LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923

Query: 512  I-------TDMKRKLKIMIHQVDELKEDI-----------SAKESALVKLHLEQQRIEKE 553
            +        D+K+  + +  + D+LK DI               +AL  L   Q+ I   
Sbjct: 924  VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983

Query: 554  KETLKAELQK---LRQQALETKHFIE--------KQEAEERKLLRIIAEA-DGERLRQKK 601
            K  +  E+ +   + +   ETK   +        KQ+ E +    + A+  D E + Q++
Sbjct: 984  KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR 1043

Query: 602  E--------------LDQVISERDILGSQL-------VRRNDELALLYEKIKIQQSVLNK 640
            +              L+ VI+E++ L + L       +   +EL LL +++K QQ ++  
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIV-- 1101

Query: 641  GESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRAL 700
               + N  ++    L     +L   +  L      ++E +Q+  ++Q E+ + + +   +
Sbjct: 1102 -AQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160

Query: 701  EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEE-VVEKEL---LLQEKEK 756
             E L+N L  ++   LE  +    EL QK++   + + S T+E  V KEL      E++ 
Sbjct: 1161 -ENLKNELK-NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH 1218

Query: 757  LYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQ---QLKVLSSELNMYEVQSKEYKYEVE 813
            L   ++ + A   G +  E+LK+    L + ++   +L+   SE     + +++ +    
Sbjct: 1219 LRGYIREIEA--TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276

Query: 814  KLTNELQNLKKKYLAQKRKEQLQKNKDT 841
            KL  E+  L ++       +++ + ++T
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQET 1304



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 167/903 (18%), Positives = 391/903 (43%), Gaps = 146/903 (16%)

Query: 9    QVLEESAFEEMERDFQGVLHELSGDKSLEK-FRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            Q+L E+  EEM    + V  E    +S+E+  ++E ++L   ++++   +     + + +
Sbjct: 1672 QILHEN-LEEM----RSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEK---AWKMVDSAYDKEQKAKETILALK 124
            +  +  +   +     +  +    I++++K++E    A K  D    +E +     L  +
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ 1786

Query: 125  EEIVN-----LTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQT 179
            +E ++     +++  ++ S +  D  ++   L    +E+     QL++    + E+  + 
Sbjct: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846

Query: 180  TEQQQETERSKEEAEHAISQFQQE---IQQRQNEASREFRKKEKLEKELKQIQADMDSRQ 236
            +E +Q  ++ K+++   +S+ + E   + Q+ +E   E +   K    L++++  +   +
Sbjct: 1847 SEMEQLKKQIKDQSL-TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905

Query: 237  TEIKALQQYVQKSKEELQKLEQQLKEQKILN-------ERAAKELEQFQMRNAKLQQENE 289
             ++K   + +Q++K    +++Q+LK  ++L+       ++  +++ +  ++ + +Q++ +
Sbjct: 1906 DQLK---ESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD 1962

Query: 290  QHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIRE-----------------Q 332
            +     ++  QE Q+K L+L   +E+V+     I ++ ++++                 Q
Sbjct: 1963 KSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQ 2022

Query: 333  IHKKLHHTED-------QKAEVEQHKETLK---NQIVGLERE----------VEASKKQA 372
            + KKLH + +       ++ E+ + KE+LK   +Q +   RE          V+  K+  
Sbjct: 2023 LTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLL 2082

Query: 373  ELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQR 432
               ++ + E LRE+    K +LK  +   +  D  +   +   +LE EI+ ++ E   + 
Sbjct: 2083 SDGQQHLTESLREKCSRIKELLKRYS---EMDDHYECLNRLSLDLEKEIE-FQKELSMRV 2138

Query: 433  KIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL--KQQQNL 490
            K    L   + ++I +     Q+  M    I  +   +  Y  KI E + +   K + + 
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198

Query: 491  YEAVRSDRNLYSKNLVEAQD------EITDMKRKLKIMIHQVDELKEDISAKESALVKLH 544
             + V   + L  K     QD      E+ D+K    + +H ++E+ +D S          
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLH-IEEILKDFS---------- 2247

Query: 545  LEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQ--KKE 602
                  E E  ++K E Q++     E   F+E+          +    D E+L+   +KE
Sbjct: 2248 ------ESEFPSIKTEFQQVLSNRKEMTQFLEEW---------LNTRFDIEKLKNGIQKE 2292

Query: 603  LDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKL 662
             D++    +   ++++      A++ E  + ++    +  +   +  +D++ L+ + +KL
Sbjct: 2293 NDRICQVNNFFNNRII------AIMNESTEFEE----RSATISKEWEQDLKSLKEKNEKL 2342

Query: 663  RREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEE--ELENPLN----------- 709
             +    L  S+A+  ++       +   +  R      E+  ELEN L+           
Sbjct: 2343 FKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKES 2402

Query: 710  --VHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLAR 767
              +   ++LE ++    +L  K+H   K  + KT+E ++   +LQ+K          L  
Sbjct: 2403 KIIKMQKELEVTNDIIAKLQAKVHESNK-CLEKTKETIQ---VLQDKV--------ALGA 2450

Query: 768  QPGPEAAEQLKLYRRTLH-DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY 826
            +P  E  E LK+    +  +K +  K    E++  +  + EY+ EV +L  E  NL++  
Sbjct: 2451 KPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKA-TVEYQKEVIRLLRE--NLRRSQ 2507

Query: 827  LAQ 829
             AQ
Sbjct: 2508 QAQ 2510



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 61/328 (18%), Positives = 143/328 (43%), Gaps = 27/328 (8%)

Query: 131  TKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRE--SLAQTTEQQQETER 188
            T+  E+ + +S +   +++ L    E++ K    L + +    +     Q  +    T R
Sbjct: 2315 TEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSR 2374

Query: 189  SKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQK 248
            + +     I + +  + + +  A  +  K  K++KEL+     +   Q ++    + ++K
Sbjct: 2375 ATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEK 2434

Query: 249  SKEELQKLEQQLKEQKILNERAAKE-LEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            +KE +Q L+ ++     L  +  KE +E  +M+  K+  E  +++   ++  +E      
Sbjct: 2435 TKETIQVLQDKVA----LGAKPYKEEIEDLKMKLVKIDLEKMKNA---KEFEKEISATKA 2487

Query: 308  ELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAE-----------VEQHKET-LK 355
             ++ ++E +  +R ++ +  + ++       HT+ Q +            V+  K   LK
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVIS-EHTDPQPSNKPLTCGGGSGIVQNTKALILK 2546

Query: 356  NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKR 415
            ++ + LE+E+   K+Q E   K  +ELL      N+++   V   +++T   + H+Q   
Sbjct: 2547 SEHIRLEKEISKLKQQNEQLIKQKNELLSN----NQHLSNEVKTWKERTLKREAHKQVTC 2602

Query: 416  NLEGEIQNYKDEAQKQRKIIFHLEKERD 443
                +       A K+++I     KER+
Sbjct: 2603 ENSPKSPKVTGTASKKKQITPSQCKERN 2630



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 112/590 (18%), Positives = 233/590 (39%), Gaps = 59/590 (10%)

Query: 34   KSLEKFRI---EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQT 90
            +SLE+ RI   E + L  + +       + +A  RE+ A    N         LS   Q 
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH 2088

Query: 91   TIASLK------KEIEKAWKMVDSAYDKEQKAKETILALKEEIV---NLTKLVEQGSGLS 141
               SL+      KE+ K +  +D  Y+   +     L L++EI     L+  V+    L 
Sbjct: 2089 LTESLREKCSRIKELLKRYSEMDDHYECLNRLS---LDLEKEIEFQKELSMRVKANLSLP 2145

Query: 142  MDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKE-------EAE 194
              Q  +I  L    +  + E  +++ ++  +   + +  E+Q E+    E       E +
Sbjct: 2146 YLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQ 2205

Query: 195  HAISQFQQEIQQRQNEASREFRK---KEKLEKELKQIQADM-DSRQTEIKA-LQQYVQKS 249
              +    Q +QQ  +  SRE R     + ++  +++I  D  +S    IK   QQ +   
Sbjct: 2206 KELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNR 2265

Query: 250  KEELQKLEQQLKEQKIL----------NERAAKELEQFQMRNAKLQQENEQHSLVCEQLS 299
            KE  Q LE+ L  +  +          N+R  +    F  R   +  E+ +       +S
Sbjct: 2266 KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS 2325

Query: 300  QENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKET--LKNQ 357
            +E +Q    LK K E++ +    +        Q++     T+D K      + T     +
Sbjct: 2326 KEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT---TQDNKNPHVTSRATQLTTEK 2382

Query: 358  IVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNL 417
            I  LE  +  +K+ A      + ++ +E ++ N  + K      +    ++  ++  + L
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVL 2442

Query: 418  EGEI----QNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDY 473
            + ++    + YK+E +  +  +  ++ E+   +  A +  +++      ++ ++  I   
Sbjct: 2443 QDKVALGAKPYKEEIEDLKMKLVKIDLEK---MKNAKEFEKEISATKATVEYQKEVIRLL 2499

Query: 474  RKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI 533
            R+ +  S+   + Q     +  +D    +K L            K  I+  +   L+++I
Sbjct: 2500 RENLRRSQ---QAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEI 2556

Query: 534  SAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
            S       KL  + +++ K+K  L +  Q L  +    K    K+EA ++
Sbjct: 2557 S-------KLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQ 2599


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  131 bits (329), Expect = 3e-30
 Identities = 179/870 (20%), Positives = 365/870 (41%), Gaps = 118/870 (13%)

Query: 36   LEKFRIEYE-RLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKV---ATALKLSQDD-QT 90
            L K +I+ E ++  V +++ D E        E+NAE+     K+    + LK   DD + 
Sbjct: 912  LIKTKIQLEAKIKEVTERAEDEE--------EINAELTAKKRKLEDECSELKKDIDDLEL 963

Query: 91   TIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRD 150
            T+A ++KE         +  +K +   E +  L E I  LTK   +   L       + D
Sbjct: 964  TLAKVEKEKH-------ATENKVKNLTEEMAGLDETIAKLTK---EKKALQEAHQQTLDD 1013

Query: 151  LLRFKEEV---TKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQR 207
            L   +++V   TK + +L  +V  L  SL Q  + + + ER+K + E  +   Q+     
Sbjct: 1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDI 1073

Query: 208  QNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILN 267
            +N+  +   K +K E E+  +Q+ ++  Q     LQ+ +++ +  +++LE++++ ++   
Sbjct: 1074 ENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASR 1133

Query: 268  ERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLN 327
             +A K+        + L +E E+ S   E+       +    K +E E  +MR D+ +  
Sbjct: 1134 AKAEKQ-------RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 328  KIREQIHKKLHHTE-DQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
               E     L     D  AE       L  QI  L+R  +  +K+    +  +D+L    
Sbjct: 1187 LQHEATAATLRKKHADSVAE-------LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 1239

Query: 387  DILNK---NMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERD 443
            + ++K   N+ K   A + Q   +K  E+ ++ L  ++   +   Q +         E+D
Sbjct: 1240 ETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD 1299

Query: 444  RYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIA-------------------ESEIKL 484
              ++Q S   Q     +E++K +  +    +  +A                   E E K 
Sbjct: 1300 TLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359

Query: 485  KQQQNLYEA---VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALV 541
            + Q+ + +A   V   R  Y  + ++  +E+ + K+KL   +   +E  E ++AK ++L 
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL- 1418

Query: 542  KLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKK 601
                     EK K+ L+ E++ L      T       + ++R   +I+AE   +      
Sbjct: 1419 ---------EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1469

Query: 602  ELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDM--------- 652
            EL+    E   L ++L +    +   YE+   Q   L +      Q + D+         
Sbjct: 1470 ELEASQKESRSLSTELFK----IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525

Query: 653  RILRLE--IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNV 710
            RI  LE   K++ +EK  L    A +EE      H + ++L+ +     ++ E++  +  
Sbjct: 1526 RIHELEKIKKQVEQEKSEL---QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI-A 1581

Query: 711  HRWRKLEASDPNAYELIQKIH-TLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQP 769
             +  +++    N   +++ +  TL   + S+ + +  K+ +  +  ++ ++L H      
Sbjct: 1582 EKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA----- 1636

Query: 770  GPEAAEQLKLYRRT--------LH---------DKKQQLKVLSSELNMYEVQSKEYKYEV 812
               AAE L+ YR T        LH         D K+QL ++    N+ + + +E +  +
Sbjct: 1637 NRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1696

Query: 813  EKLTNELQNLKKKYLAQKRKEQLQKNKDTA 842
            E+     +  +++ L    + QL   ++T+
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQNTS 1726



 Score =  116 bits (290), Expect = 1e-25
 Identities = 171/858 (19%), Positives = 358/858 (41%), Gaps = 134/858 (15%)

Query: 40   RIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSA---------KVATALKLSQDDQT 90
            R+EY+++          E+R    C + N    +N           K+   LK S + + 
Sbjct: 802  RVEYQKMV---------ERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLK-SAETEK 851

Query: 91   TIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRD 150
             +A++K+E EK  + +     K ++ +E ++ L +E  +L   V+  +    D       
Sbjct: 852  EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQ 911

Query: 151  LLRFK---------------------EEVTKERDQLLSEVVKLRESLAQTTEQQQETERS 189
            L++ K                      E+T ++ +L  E  +L++ +        + E+ 
Sbjct: 912  LIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 971

Query: 190  KEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKS 249
            K   E+ +    +E+       ++  ++K+ L++  +Q   D+ + + ++  L +   K 
Sbjct: 972  KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKL 1031

Query: 250  KEELQKLEQQLKEQKILN---ERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKA 306
            ++++  LE  L+++K +    ERA ++LE     + KL QE+         +  + QQ  
Sbjct: 1032 EQQVDDLEGSLEQEKKIRMDLERAKRKLE----GDLKLAQESTM------DIENDKQQLD 1081

Query: 307  LELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE 366
             +LK KE E+  ++  I     +  Q+ KK+   ++ +A +E+           LE E+E
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQLQKKI---KELQARIEE-----------LEEEIE 1127

Query: 367  ASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHE----QAKRNLEGEIQ 422
            A +       K   +L RE + +++ + +A  AT  Q ++ K  E    + +R+LE    
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187

Query: 423  NYKDEAQKQRK-----------IIFHLEKERDRYINQASDLTQKV---LMNMEDIKVRET 468
             ++  A   RK            I +L++ + +   + S++  ++     NME +   + 
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247

Query: 469  QIFDYRKKIAE--SEIKLK--QQQNLYEAVRSDR-------NLYSKNLVEAQDEITDMKR 517
             +    + + +  SEIK K  +QQ L   + + R         YS+ L E    ++ + R
Sbjct: 1248 NLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307

Query: 518  KLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEK 577
              +    Q++ELK  +  +               K K  L   LQ  R      +   E+
Sbjct: 1308 GKQAFTQQIEELKRQLEEE--------------IKAKSALAHALQSSRHDCDLLREQYEE 1353

Query: 578  QEAEERKLLRIIAEADGE--RLRQKKELD--QVISERDILGSQLVRRNDELALLYEKIKI 633
            ++  + +L R +++A+ E  + R K E D  Q   E +    +L +R  +     E +  
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNA 1413

Query: 634  QQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVE----ELRQEFFHMQRE 689
            + + L K + +    +ED   L +++++       L +   N +    E +Q+      E
Sbjct: 1414 KCASLEKTKQRLQNEVED---LMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1470

Query: 690  LLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKEL 749
            L   +   R+L  EL    N +     E S      L ++   LQ+ +   TE++ E   
Sbjct: 1471 LEASQKESRSLSTELFKIKNAY-----EESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525

Query: 750  LLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYK 809
             + E EK+  +++     Q   E    L+    +L  + ++ K+L  +L + +V+S E  
Sbjct: 1526 RIHELEKIKKQVE-----QEKSELQAALEEAEASL--EHEEGKILRIQLELNQVKS-EVD 1577

Query: 810  YEVEKLTNELQNLKKKYL 827
             ++ +   E+  +K+ ++
Sbjct: 1578 RKIAEKDEEIDQMKRNHI 1595



 Score =  104 bits (259), Expect = 4e-22
 Identities = 168/816 (20%), Positives = 341/816 (41%), Gaps = 107/816 (13%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMA 62
            EE GG    +    ++ E +FQ +  +L      E+  +++E   A ++K + +    + 
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDL------EEATLQHEATAATLRKKHADSVAELG 1208

Query: 63   KCRELNAEIVVNSAKVATALKLSQDD----QTTIASLKKEIEKAWKMVDSAYD----KEQ 114
            +  +    +     K  + +K+  DD      T++  K  +EK  + ++        KE+
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268

Query: 115  KAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQL---LSEVVK 171
            + +  I  L  +   L     + S    ++ + +  L R K+  T++ ++L   L E +K
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK 1328

Query: 172  LRESLAQTT-----------EQQQETERSKEEAEHAISQFQQEIQQ----RQNEASREFR 216
             + +LA              EQ +E + +K E + A+S+   E+ Q     + +A +   
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388

Query: 217  KKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQL---------------K 261
            + E+ +K+L Q   D +     + A    ++K+K+ LQ   + L               K
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448

Query: 262  EQ----KILNERAAK------ELEQFQMRNAKLQQE-------NEQHSLVCEQLSQENQQ 304
            +Q    KIL E   K      ELE  Q  +  L  E        E+     E L +EN+ 
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508

Query: 305  KALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLERE 364
               E+    E++ +    I +L KI++Q+ ++    +    E E   E  + +I  L  +
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI--LRIQ 1566

Query: 365  VEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNY 424
            +E ++ ++E+DRK + E   E D + +N ++ V + Q               L+ EI++ 
Sbjct: 1567 LELNQVKSEVDRK-IAEKDEEIDQMKRNHIRIVESMQS-------------TLDAEIRSR 1612

Query: 425  KDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIK--VRETQIFDYRKKIAESEI 482
             D  + ++K+   L  E +  +N A+ +  + L N  + +  +++TQ+  +      S+ 
Sbjct: 1613 NDAIRLKKKMEGDL-NEMEIQLNHANRMAAEALRNYRNTQAILKDTQL--HLDDALRSQE 1669

Query: 483  KLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVK 542
             LK+Q  +   V    NL    + E +  +   +R  KI   ++ +  E +    +    
Sbjct: 1670 DLKEQLAM---VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726

Query: 543  LHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKL---LRIIAEADGERLRQ 599
            L   ++++E +   ++ E++ + Q+A   +   +K   +   +   L+   +      R 
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786

Query: 600  KKELDQVISERDILGSQLVRRNDE---LALLYEKIKIQQSVLNKGESQYNQRLEDMRILR 656
            KK L+Q + +       L  R DE   LAL   K +IQ+      E +     E  R + 
Sbjct: 1787 KKNLEQTVKD-------LQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVE 1839

Query: 657  LEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCR-----ALEEELENPLNVH 711
              +K LR+ +  +       EE R+    +Q  + K + + +     A E E ++ +N+ 
Sbjct: 1840 -AVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLS 1898

Query: 712  RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEK 747
            ++R+++     A E      +   +L  K+ EV  K
Sbjct: 1899 KFRRIQHELEEAEERADIAESQVNKLRVKSREVHTK 1934



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 120/625 (19%), Positives = 270/625 (43%), Gaps = 86/625 (13%)

Query: 10   VLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNE--KRLMAKCREL 67
            +L E   EE E   +        +  + ++R +YE   A+ +     E  K+L  + ++ 
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET-DAIQRTEELEEAKKKLAQRLQDA 1404

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
               +   +AK A+  K  Q  Q  +  L  ++E+      +A DK+Q+            
Sbjct: 1405 EEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT-NAACAALDKKQR------------ 1451

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
             N  K++ +      + H+ +       E   KE   L +E+ K++ +  ++ +Q +  +
Sbjct: 1452 -NFDKILAEWKQKCEETHAEL-------EASQKESRSLSTELFKIKNAYEESLDQLETLK 1503

Query: 188  RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
            R  +  +  IS   ++I +         + K+++E+E  ++QA ++  +  ++  +  + 
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKIL 1563

Query: 248  KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            + + EL +++ ++ ++KI    A K+ E  QM+   ++      S +  ++   N   A+
Sbjct: 1564 RIQLELNQVKSEV-DRKI----AEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRND--AI 1616

Query: 308  ELKAKEE-EVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH-------KETLKNQIV 359
             LK K E ++++M + +   N++  +  +   +T+    + + H       +E LK Q+ 
Sbjct: 1617 RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLA 1676

Query: 360  GLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQ----KQTDLVKLHEQAKR 415
             +ER     + + E  R  +++  R R I  + +L A    Q    + T L+   ++ + 
Sbjct: 1677 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1736

Query: 416  NL---EGEIQNYKDEAQ---------------------KQRKIIFHLEKERDRYINQASD 451
            ++   +GE+++   EA+                     K++    HLE+ +        D
Sbjct: 1737 DISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD 1796

Query: 452  LTQKVLMNMEDIKVR----ETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRN-------- 499
            L  + L   E + ++    + Q  + R +  E E++ +Q++N+ EAV+  R         
Sbjct: 1797 LQHR-LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNV-EAVKGLRKHERKVKEL 1854

Query: 500  LYS-----KNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEK 554
             Y      KN++  QD +  ++ K+K    Q +E +E  +   S   ++  E +  E+  
Sbjct: 1855 TYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERA 1914

Query: 555  ETLKAELQKLRQQALETKHFIEKQE 579
            +  ++++ KLR ++ E    I  +E
Sbjct: 1915 DIAESQVNKLRVKSREVHTKIISEE 1939


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score =  130 bits (328), Expect = 4e-30
 Identities = 190/937 (20%), Positives = 413/937 (44%), Gaps = 141/937 (15%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL 60
            + +EK G  V++++  +  + +   ++H+L           E ++L A +K+     K  
Sbjct: 307  LLKEKSG--VIQDALKKSSKGELTTLIHQLQ----------EKDKLLAAVKEDAAATKD- 353

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
              +C++L  E++    +    +   +D    I +L+KE       +  +Y + Q+ +   
Sbjct: 354  --RCKQLTQEMMTEKERSNVVITRMKD---RIGTLEKEHNVFQNKIHVSYQETQQMQMKF 408

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT 180
              ++E++      ++Q +G+  D  SN  + L  K+    E ++L  +  +L   L + T
Sbjct: 409  QQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA--ELNKLRQDYARLVNELTEKT 466

Query: 181  EQQQETERSKEEAEHAISQFQQEIQQ--RQNEASREFRKKEKLEKELKQ--IQADMDSRQ 236
             + Q+ E  K+ AE A +Q + ++Q+  R+ E  + + +K   E E  Q  +Q+   +++
Sbjct: 467  GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526

Query: 237  TEIKALQQYVQKSKEELQKLEQQL-----KEQKILNERAAKE------LEQFQMRNAKLQ 285
             E+++L   +  +    Q+LEQ+L      EQK +N+  + +      LEQ +   A++Q
Sbjct: 527  NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586

Query: 286  QENEQ--------------HSLVCE---QLSQENQQKALE---LKAKEEEVHQMRLDIGK 325
            Q + Q              H ++ E   Q+ Q     A E   L +KEEE+     DI  
Sbjct: 587  QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK----DIQN 642

Query: 326  LNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRE 385
            +N + +   +KL    +++A      E ++  +   + ++   ++Q + +   +   + E
Sbjct: 643  MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE---ISNKMEE 699

Query: 386  RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHL------- 438
              ILN       +  QK   LV   EQ  +++  +++    E  ++ K +  L       
Sbjct: 700  FKILNDQNKALKSEVQKLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757

Query: 439  ----EKERDRYINQASDLTQKVLMNMEDIKVRETQ-------IFDYRKKIAESEIKLKQQ 487
                E+E +    + S LT++V    +D+K ++         + + +K I E + K+K  
Sbjct: 758  VATKEEELNAIRTENSSLTKEV----QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813

Query: 488  QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQ 547
            + L EA           +   +  + D+K+++K +  ++  ++ +  A++ ++     E 
Sbjct: 814  EELLEA-------ELLKVANKEKTVQDLKQEIKALKEEIGNVQLE-KAQQLSITSKVQEL 865

Query: 548  QRIEKEKE----TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKEL 603
            Q + K KE    T+KA L++  +    T  +++  + E   L   + E     L++    
Sbjct: 866  QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925

Query: 604  DQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLR 663
             Q   E +I+   L  + +EL  L   +K ++S L+          ++ ++ + +I++L+
Sbjct: 926  SQ-FEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 981

Query: 664  REKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELEN--PLNVHRWRKLEASDP 721
            ++    A S    EEL +     ++E+        +L++ +E+    N  R +++EA + 
Sbjct: 982  QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVEL 1041

Query: 722  NAYELIQK----------------IHTLQKRL------ISKTEEVVEKELLLQEKEKLYM 759
             A E+++K                +H  +K+        S +EEV   E  L+E ++++ 
Sbjct: 1042 EAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT 1101

Query: 760  EL-------KHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSK--EYKY 810
             L       K VLA   G     Q  + +    + K ++KV  S   + ++QS     + 
Sbjct: 1102 LLQLECEKYKSVLAETEGILQKLQRSVEQ---EENKWKVKVDESHKTIKQMQSSFTSSEQ 1158

Query: 811  EVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPMDNT 847
            E+E+L +E ++++     ++ +E L+   + A M+ +
Sbjct: 1159 ELERLRSENKDIEN---LRREREHLEMELEKAEMERS 1192



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 157/812 (19%), Positives = 335/812 (41%), Gaps = 131/812 (16%)

Query: 86   QDDQTTIASLKKEIEKAW-KMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQ 144
            QD Q+   + + E++    K+ D+   K+Q  +  +  ++ E     K V +   L M  
Sbjct: 516  QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE----QKRVNKEESLQMQ- 570

Query: 145  HSNIRDLLRFKEEVTKERDQLLSEVV----------KLRESLAQTTEQQQETERSKEEAE 194
               ++D+L   E +  +  Q  S++           +L + +A+  +Q ++TE S     
Sbjct: 571  ---VQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER 627

Query: 195  HAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQ 254
              ++  ++E++  QN     F  K +++K L+ +  +  +   E++ +QQ V    ++++
Sbjct: 628  DRLTSKEEELKDIQN---MNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683

Query: 255  KLEQQLKEQ--------KILNER-AAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQK 305
             LE+QL+ +        KILN++  A + E  +++    +Q N+      E+  QE  +K
Sbjct: 684  LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743

Query: 306  A-----------LELKAKEEEVHQMRLDIGKLNK-----------------IREQIHKKL 337
                        +++  KEEE++ +R +   L K                 + E++ K +
Sbjct: 744  LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803

Query: 338  HHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAV 397
            H  + +   VE+  E    ++   E+ V+  K++     KA+ E +    +     L   
Sbjct: 804  HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI----KALKEEIGNVQLEKAQQLSIT 859

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
            +  Q+  +L+K  E+    ++  ++  + +     K +  L++E +       ++ Q  L
Sbjct: 860  SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 919

Query: 458  MNMED----------IKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVE 507
                           +K +E ++      + E E  L  +  L + V+ +  L+   + +
Sbjct: 920  KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979

Query: 508  AQDE-----------------ITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRI 550
             + +                 I++ ++++  + +++D LK+   A E    K +  QQ++
Sbjct: 980  LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD---AVEHQRKKNNERQQQV 1036

Query: 551  EKEKETLKAELQKLRQQAL--------ETKHFIEKQE---------AEERKLLRI-IAEA 592
            E  +   K  L+KL  +          E  H  EK+          +EE K+L   + EA
Sbjct: 1037 EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA 1096

Query: 593  DGERLRQKKELDQ---VISERDILGSQLVRRNDELALLYEKIKIQQS--VLNKGESQYN- 646
            D      + E ++   V++E + +  +L R  ++    + K+K+ +S   + + +S +  
Sbjct: 1097 DEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKW-KVKVDESHKTIKQMQSSFTS 1155

Query: 647  --QRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEEL 704
              Q LE +R    +I+ LRRE+  L   +   E  R  +    REL  +      L E L
Sbjct: 1156 SEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQ------LNETL 1209

Query: 705  ENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEE--VVEKELLLQEKEKLYMELK 762
                     R+  A D   ++  Q +  +Q +++    +  V+E   +  E E    E  
Sbjct: 1210 TKLRTEQNERQKVAGD--LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM 1267

Query: 763  HVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL 794
             V   Q   +  + L+   + L  +K+  +VL
Sbjct: 1268 SVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1299



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 119/559 (21%), Positives = 252/559 (45%), Gaps = 62/559 (11%)

Query: 59   RLMAKCRELNAEIVVNSA--KVATALKLSQDDQTTIASLKKEIEKAW-------KMVDSA 109
            ++  K  ELNA    NS+  K    LK  Q+DQ + ASL +E++K         K V+  
Sbjct: 757  QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816

Query: 110  YDKE-----------QKAKETILALKEEIVNLTKLVEQGSGLSMDQH-SNIRDLLRFKEE 157
             + E           Q  K+ I ALKEEI N+   +E+   LS+      +++LL+ KEE
Sbjct: 817  LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ--LEKAQQLSITSKVQELQNLLKGKEE 874

Query: 158  VTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASR---- 213
                   +L E  K    LA T +  Q+ +   E  +  + +  Q   +  + AS+    
Sbjct: 875  QMNTMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL 931

Query: 214  EFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE 273
            E   KEK E ELK+++A +  R++++ +  Q +Q  ++E +  + Q+++ K  N + A  
Sbjct: 932  EIVLKEK-ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 990

Query: 274  LEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQI 333
                +     + +  ++ S +  +L  ++ + A+E + K+    Q +++  +L    +++
Sbjct: 991  FPPHEELLKVISEREKEISGLWNEL--DSLKDAVEHQRKKNNERQQQVEAVELEA--KEV 1046

Query: 334  HKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEA--SKKQAELDRKAMDELLRERDILNK 391
             KKL      K  V  +  +    + G E++ +   +      + K ++  L+E D ++ 
Sbjct: 1047 LKKLF----PKVSVPSNL-SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT 1101

Query: 392  NM-LKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHL-------EKERD 443
             + L+         +   + ++ +R++E E   +K +  +  K I  +       E+E +
Sbjct: 1102 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1161

Query: 444  RYINQASDLT------QKVLMNMEDIKVRE----TQIFDYRKKIAESEIKLKQQQNLYEA 493
            R  ++  D+       + + M +E  ++      T++ + + ++ E+  KL+ +QN  + 
Sbjct: 1162 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQK 1221

Query: 494  VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKE 553
            V  D +   ++L   Q +I        ++ +     + + S KE+  V L+    ++++ 
Sbjct: 1222 VAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQL 1281

Query: 554  KETLKAELQKLRQ--QALE 570
             + +  +L K ++  Q LE
Sbjct: 1282 LQAVNQQLTKEKEHYQVLE 1300



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 69/379 (18%), Positives = 154/379 (40%), Gaps = 54/379 (14%)

Query: 42   EYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEK 101
            ++E L  V+K+  +  KRL A  +E  +++       ++  +L QD Q      K +IE+
Sbjct: 927  QFEELEIVLKEKENELKRLEAMLKERESDL-------SSKTQLLQDVQDENKLFKSQIEQ 979

Query: 102  AWKM---VDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEV 158
              +      S++   ++  + I   ++EI  L   ++        Q     +  +  E V
Sbjct: 980  LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAV 1039

Query: 159  TKERDQLLSEVV--------------------KLRESLAQTT--EQQQETERSKEEAEHA 196
              E  ++L ++                     K +E +A T+  E+ +  E   +EA+  
Sbjct: 1040 ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEM 1099

Query: 197  ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQ----ADMDSRQTEIKALQQYVQKSKEE 252
             +  Q E ++ ++  +      +KL++ ++Q +      +D     IK +Q     S++E
Sbjct: 1100 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1159

Query: 253  LQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAK 312
            L++L  + K+     E   +E E  +M   K + E   +     +L  +  +   +L+ +
Sbjct: 1160 LERLRSENKD----IENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTE 1215

Query: 313  EEEVHQMRLDIGKLNKIREQIHKKLHHT--------------EDQKAEVEQHKETLKNQI 358
            + E  ++  D+ K  +  E I  K+                 E + +E E    +L   +
Sbjct: 1216 QNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTV 1275

Query: 359  VGLEREVEASKKQAELDRK 377
              L++ ++A  +Q   +++
Sbjct: 1276 TQLQQLLQAVNQQLTKEKE 1294


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  130 bits (328), Expect = 4e-30
 Identities = 166/812 (20%), Positives = 349/812 (42%), Gaps = 92/812 (11%)

Query: 77   KVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQ 136
            K+   LK S + +  +A++K+E +K    +  +  K ++ +E ++ L +E  +L   V+ 
Sbjct: 836  KIKPLLK-SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQA 894

Query: 137  GSGLSMDQHSNIRDLLRFK---------------------EEVTKERDQLLSEVVKLRES 175
             S   +D       L++ K                      E+T ++ +L  E  +L++ 
Sbjct: 895  ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 954

Query: 176  LAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSR 235
            +        + E+ K   E+ +    +E+       ++  R+K+ L++  +Q   D+ + 
Sbjct: 955  IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014

Query: 236  QTEIKALQQYVQKSKEELQKLEQQLKEQKILN---ERAAKELEQFQMRNAKLQQENEQHS 292
            + ++ +L +   K +++++ LE  L+++K L    ER  ++LE     + KL QE+    
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLE----GDLKLAQES---- 1066

Query: 293  LVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKE 352
                 L  + QQ    LK K+ E  Q++  +     +  Q  KK+   ++ +A +E+   
Sbjct: 1067 --ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI---KELQARIEE--- 1118

Query: 353  TLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHE- 411
                    LE E+EA +       K   +  RE + L++ + +A   T  Q +L K  E 
Sbjct: 1119 --------LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREA 1170

Query: 412  ---QAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRET 468
               + +R+LE     ++      RK       E    I+    + QK+     + K+   
Sbjct: 1171 EFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID 1230

Query: 469  QIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDE 528
             +    + +++S+  L++     E   S+    ++ +  +  E+T  K +L+    +  E
Sbjct: 1231 DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT---EAGE 1287

Query: 529  LKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFI------------- 575
            L   +  KES + +L   +Q   ++ E LK +L++  +      H +             
Sbjct: 1288 LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQ 1347

Query: 576  -EKQEAEERKLLRIIAEADGE--RLRQKKELD--QVISERDILGSQLVRRNDELALLYEK 630
             E+++  + +L R +++A+ E  + R K E D  Q   E +    +L +R  +     E 
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

Query: 631  IKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQREL 690
            +  + + L K + +    +ED   L +++++        A S+A   + +Q  F   + L
Sbjct: 1408 VNAKCASLEKTKQRLQGEVED---LMVDVER--------ANSLAAALDKKQRNF--DKVL 1454

Query: 691  LKERTRCRALEEELENPLNVHRWRKLEASD-PNAY-ELIQKIHTLQKRLISKTEEVVEKE 748
             + +T+C   + ELE  L   R    E     NAY E + ++ T+++   +  +E+ +  
Sbjct: 1455 AEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLT 1514

Query: 749  LLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEY 808
              + E  K   EL+    +    +A  QL L       + ++ K+L  +L + +V+S E 
Sbjct: 1515 EQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS-EI 1573

Query: 809  KYEVEKLTNELQNLKKKYLAQKRKEQLQKNKD 840
              ++ +   E++ LK+ Y  Q+  E +Q   D
Sbjct: 1574 DRKIAEKDEEIEQLKRNY--QRTVETMQSALD 1603



 Score =  121 bits (303), Expect = 3e-27
 Identities = 161/853 (18%), Positives = 370/853 (43%), Gaps = 90/853 (10%)

Query: 38   KFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKV---ATALKLSQDD-QTTIA 93
            KF++E  ++  V +++ D E        E+NAE+     K+    + LK   DD + T+A
Sbjct: 913  KFQLE-AKIKEVTERAEDEE--------EINAELTAKKRKLEDECSELKKDIDDLELTLA 963

Query: 94   SLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLR 153
             ++KE       V +  ++     ETI  L  E     K +++    ++D      D + 
Sbjct: 964  KVEKEKHATENKVKNLTEELSGLDETIAKLTRE----KKALQEAHQQALDDLQAEEDKVN 1019

Query: 154  FKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASR 213
                + K + +L  +V  L  SL Q  + + + ER+K + E  +   Q+ I   +N+  +
Sbjct: 1020 ---SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQ 1076

Query: 214  EFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE 273
               + +K + E  Q+Q+ ++  QT     Q+ +++ +  +++LE++++ ++    +  K+
Sbjct: 1077 LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136

Query: 274  LEQFQMRNAKLQQENEQHSLVCE---QLSQENQQKALELKAK-EEEVHQMRLDIGKLNKI 329
               +     +L +  E+   V     +L+++ + + L+L+   EE   Q    +  L K 
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK 1196

Query: 330  R----EQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEA-SKKQAELDR--KAMDEL 382
                  ++ +++ + +  K ++E+ K   K +I  L   +E+ SK +A L++  + +++ 
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ 1256

Query: 383  LRERDILNKNMLKAVN--ATQK---QTDLVKLHEQ--AKRNLEGEIQNYKDEAQKQRKII 435
            L E    N+ + ++++   TQK   QT+  +L  Q   K ++  ++   K    +Q +  
Sbjct: 1257 LSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTE-- 1314

Query: 436  FHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVR 495
              L+++ +      + L   +  +  D  +   Q  + ++  AE +  L +  +    V 
Sbjct: 1315 -ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS---EVA 1370

Query: 496  SDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKE 555
              R  Y  + ++  +E+ + K+KL   +   +E  E ++AK ++L          EK K+
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL----------EKTKQ 1420

Query: 556  TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGS 615
             L+ E++ L              + ++R   +++AE   +    + EL+  + E   L +
Sbjct: 1421 RLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLST 1480

Query: 616  QLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLE----IKKLRREKGILAR 671
            +L +    L   YE+   Q   + +      Q + D+     E    I +L + +  +  
Sbjct: 1481 ELFK----LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIEL 1536

Query: 672  SMANV----EELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
              A++    EE      H + ++L+ +     ++ E++  +   +  ++E    N    +
Sbjct: 1537 EKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKI-AEKDEEIEQLKRNYQRTV 1595

Query: 728  QKIHT-LQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYR----- 781
            + + + L   + S+ E +  K+ +  +  ++ ++L H        +AAE LK  R     
Sbjct: 1596 ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA-----NRQAAETLKHLRSVQGQ 1650

Query: 782  ------------RTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQ 829
                        R   D K+QL ++    N+ + + +E +  +E+     +  +++ L  
Sbjct: 1651 LKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDS 1710

Query: 830  KRKEQLQKNKDTA 842
              + QL   ++T+
Sbjct: 1711 NERVQLLHTQNTS 1723



 Score =  116 bits (290), Expect = 1e-25
 Identities = 169/893 (18%), Positives = 364/893 (40%), Gaps = 153/893 (17%)

Query: 7    GKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYD-------NEKR 59
            G   L + +  ++E D Q +      D+ L+K   EY +L + ++             K 
Sbjct: 1058 GDLKLAQESILDLENDKQQL------DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111

Query: 60   LMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKET 119
            L A+  EL  EI    A  A   K   D    +  L + +E+A  +  +  +  +K +  
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 1171

Query: 120  ILALKEEIVNLTKLVEQGSGLSMDQHSN--------IRDLLRFKEEVTKERDQLLSEVVK 171
             L L+ ++   T   E        +H++        I +L R K+++ KE+ +   E+  
Sbjct: 1172 FLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD 1231

Query: 172  LRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQAD 231
            L  S+   ++ +   E+     E  +S+ + + ++ Q   S    +K +L+ E  ++   
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291

Query: 232  MDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQ----MRNAKLQQE 287
            ++ +++ +  L +  Q   ++ ++L++QL+E+       A  L+  +    +   + ++E
Sbjct: 1292 LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEE 1351

Query: 288  NEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQK--- 344
             E  + +   LS+ N + A + + K E     R +  +L + ++++ ++L  +E+Q    
Sbjct: 1352 QEGKAELQRALSKANSEVA-QWRTKYETDAIQRTE--ELEEAKKKLAQRLQDSEEQVEAV 1408

Query: 345  ----AEVEQHKETLKNQIVGLEREVE-ASKKQAELDRKA--------------------M 379
                A +E+ K+ L+ ++  L  +VE A+   A LD+K                     +
Sbjct: 1409 NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL 1468

Query: 380  DELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLE 439
            +  L+E   L+  + K  NA ++  D ++  ++  +NLE EI +  ++  +  K I  LE
Sbjct: 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE 1528

Query: 440  KERDRYINQASDLT-----QKVLMNMEDIKVRETQI------FDYRKKIAESEIKLKQQQ 488
            K R +   + +D+       +  +  E+ K+   Q+       +  +KIAE + +++Q +
Sbjct: 1529 KSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLK 1588

Query: 489  NLY-------------------EAVRSDRNLYS--------------------KNLVEAQ 509
              Y                   EA+R  + +                      K+L   Q
Sbjct: 1589 RNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQ 1648

Query: 510  DEITD--------------MKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKE 555
             ++ D              +K +L I+  + + L+ ++    + L +    ++  E+E  
Sbjct: 1649 GQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELL 1708

Query: 556  TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGS 615
                 +Q L  Q     H  +K E +  +L   + +A  +    +++  + I++  ++  
Sbjct: 1709 DSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAE 1768

Query: 616  QLVRRNDELALLYE-KIKIQQSVLN-------------KGESQYNQRLEDMRILRLE--- 658
            +L +  D  A L   K  ++Q+V +             KG  +  Q+LE  RI  LE   
Sbjct: 1769 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE-TRIRELEFEL 1827

Query: 659  ----------IKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALE---EELE 705
                      +K LR+ +  +       EE R+    +Q  + K + + ++ +   EE +
Sbjct: 1828 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAD 1887

Query: 706  NPLNVH--RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEK 756
               N H  ++RK +     A E      +   +L +KT +     +++ E E+
Sbjct: 1888 EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  130 bits (327), Expect = 5e-30
 Identities = 186/929 (20%), Positives = 400/929 (43%), Gaps = 122/929 (13%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL 60
            + +EK G  V++++  +  + +   ++H+L           E ++L A +K+     K  
Sbjct: 307  LLKEKSG--VIQDALKKSSKGELTTLIHQLQ----------EKDKLLAAVKEDAAATKD- 353

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
              +C++L  E++    +    +   +D    I +L+KE       +  +Y + Q+ +   
Sbjct: 354  --RCKQLTQEMMTEKERSNVVITRMKD---RIGTLEKEHNVFQNKIHVSYQETQQMQMKF 408

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT 180
              ++E++      ++Q +G+  D  SN  + L  K+    E ++L  +  +L   L + T
Sbjct: 409  QQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA--ELNKLRQDYARLVNELTEKT 466

Query: 181  EQQQETERSKEEAEHAISQFQQEIQQ--RQNEASREFRKKEKLEKELKQ--IQADMDSRQ 236
             + Q+ E  K+ AE A +Q + ++Q+  R+ E  + + +K   E E  Q  +Q+   +++
Sbjct: 467  GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526

Query: 237  TEIKALQQYVQKSKEELQKLEQQL-----KEQKILNERAAKE------LEQFQMRNAKLQ 285
             E+++L   +  +    Q+LEQ+L      EQK +N+  + +      LEQ +   A++Q
Sbjct: 527  NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586

Query: 286  QENEQ--------------HSLVCE---QLSQENQQKALE---LKAKEEEVHQMRLDIGK 325
            Q + Q              H ++ E   Q+ Q     A E   L +KEEE+     DI  
Sbjct: 587  QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK----DIQN 642

Query: 326  LNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRE 385
            +N + +   +KL    +++A      E ++  +   + ++   ++Q + +   +   + E
Sbjct: 643  MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE---ISNKMEE 699

Query: 386  RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHL------- 438
              ILN       +  QK   LV   EQ  +++  +++    E  ++ K +  L       
Sbjct: 700  FKILNDQNKALKSEVQKLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757

Query: 439  ----EKERDRYINQASDLTQKVLMNMEDIKVRETQ-------IFDYRKKIAESEIKLKQQ 487
                E+E +    + S LT++V    +D+K ++         + + +K I E + K+K  
Sbjct: 758  VATKEEELNAIRTENSSLTKEV----QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813

Query: 488  QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQ 547
            + L EA           +   +  + D+K+++K +  ++  ++ + + + S   K+  E 
Sbjct: 814  EELLEAELL-------KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-EL 865

Query: 548  QRIEKEKE----TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKEL 603
            Q + K KE    T+KA L++  +    T  +++  + E   L   + E     L++    
Sbjct: 866  QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925

Query: 604  DQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLR 663
             Q   E +I+   L  + +EL  L   +K ++S L+          ++ ++ + +I++L+
Sbjct: 926  SQ-FEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 981

Query: 664  REKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNA 723
            ++    A S    EEL +     ++E+        +L++ +E     H+ +K        
Sbjct: 982  QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE-----HQRKKNNDLREKN 1036

Query: 724  YELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRT 783
            +E ++ + + +K L  K  +  ++    Q+ E + +E K VL +     +      Y   
Sbjct: 1037 WEAMEALASTEKMLQDKVNKTSKERQ--QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEW 1094

Query: 784  LH--DKK-----------QQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQK 830
            LH  +KK           +++KVL  +L   +      + E EK  + L   +      +
Sbjct: 1095 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1154

Query: 831  RKEQLQKNKDTAPMDNTFLMVKPNGPGFT 859
            R  + ++NK    +D +   +K     FT
Sbjct: 1155 RSVEQEENKWKVKVDESHKTIKQMQSSFT 1183



 Score =  100 bits (250), Expect = 4e-21
 Identities = 145/704 (20%), Positives = 313/704 (44%), Gaps = 69/704 (9%)

Query: 37   EKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLK 96
            +K R+  E+L   +    +  K L  + + L +E+     K+ T +   Q ++  +  ++
Sbjct: 680  DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV----QKLQTLVS-EQPNKDVVEQME 734

Query: 97   KEIEK-------AWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIR 149
            K I++         +++++   +    +E + A++ E  +LTK V+       DQ S   
Sbjct: 735  KCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS-FA 793

Query: 150  DLLRFKEEVTKERDQLLSEVVKLRES-LAQTTEQQQETERSKEEAEHAISQFQQEIQQRQ 208
             L+   ++V  E+D  +  V +L E+ L +   +++  +  K+E    I   ++EI   Q
Sbjct: 794  SLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQE----IKALKEEIGNVQ 849

Query: 209  NEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNE 268
             E +++     K++ EL+ +    + +   +KA+ +  +K      K  Q L+E+    +
Sbjct: 850  LEKAQQLSITSKVQ-ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLK 908

Query: 269  RAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVH-----QMRLDI 323
               +E+ Q  ++ A    + E+  +V ++  +EN+ K LE   KE E       Q+  D+
Sbjct: 909  AHVQEVAQHNLKEASSASQFEELEIVLKE--KENELKRLEAMLKERESDLSSKTQLLQDV 966

Query: 324  GKLNKI-REQIHKKLHHTEDQKAEVEQHKETLK------NQIVGLEREVEASKKQAELDR 376
               NK+ + QI +       Q +    H+E LK       +I GL  E+++ K   E  R
Sbjct: 967  QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1026

Query: 377  KAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIF 436
            K  ++L RE+   N   ++A+ +T+K     K+++ +K   + +++  + EA++  K +F
Sbjct: 1027 KKNNDL-REK---NWEAMEALASTEKMLQ-DKVNKTSKERQQ-QVEAVELEAKEVLKKLF 1080

Query: 437  HLEKERDRYINQASDLTQKVLMNMEDIKVRETQI-FDYRKKIAESEIKLKQQQNLYEAVR 495
                     ++  S+L+    ++  + K +E        +++   E KLK+   ++  ++
Sbjct: 1081 PK-------VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1133

Query: 496  SDRNLYSKNLVEAQDEITDMKRKLKIMIHQ----VDELKEDISAKESALVKLHLEQQRIE 551
             +   Y   L E +  +  ++R ++   ++    VDE  + I   +S+      E +R+ 
Sbjct: 1134 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193

Query: 552  KEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERD 611
             E +    +++ LR++    +  +EK E E    +  + E        +K+LD   SE  
Sbjct: 1194 SENK----DIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSE-- 1247

Query: 612  ILGSQLVRRNDELALL-------YEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRR 664
                  VR+N+EL LL         K++ +Q+   K     ++  + + +++ +I K   
Sbjct: 1248 -----AVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1302

Query: 665  EKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPL 708
            +  ++  S  + E    E   M   L +  T+ + L + +   L
Sbjct: 1303 DTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1346



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 129/609 (21%), Positives = 256/609 (42%), Gaps = 105/609 (17%)

Query: 59   RLMAKCRELNAEIVVNSA--KVATALKLSQDDQTTIASLKKEIEKAW-------KMVDSA 109
            ++  K  ELNA    NS+  K    LK  Q+DQ + ASL +E++K         K V+  
Sbjct: 757  QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816

Query: 110  YDKE-----------QKAKETILALKEEIVNLTKLVEQGSGLSMDQH-SNIRDLLRFKEE 157
             + E           Q  K+ I ALKEEI N+   +E+   LS+      +++LL+ KEE
Sbjct: 817  LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ--LEKAQQLSITSKVQELQNLLKGKEE 874

Query: 158  VTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASR---- 213
                   +L E  K    LA T +  Q+ +   E  +  + +  Q   +  + AS+    
Sbjct: 875  QMNTMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL 931

Query: 214  EFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE 273
            E   KEK E ELK+++A +  R++++ +  Q +Q  ++E +  + Q+++ K  N + A  
Sbjct: 932  EIVLKEK-ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 990

Query: 274  LEQFQMRNAKLQQENEQHSLVCEQLS------QENQQKALELKAKEEEVHQMRLDIGKLN 327
                +     + +  ++ S +  +L       +  ++K  +L+ K  E  +      K+ 
Sbjct: 991  FPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM- 1049

Query: 328  KIREQIHKKLHHTEDQKAEVE-QHKETLKNQ---------------IVGLEREVEA--SK 369
             ++++++K     + Q   VE + KE LK                 + G E++ +   + 
Sbjct: 1050 -LQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1108

Query: 370  KQAELDRKAMDELLRERDILN-----------------KNMLKAVNATQKQTD---LVKL 409
                 + K ++  L+E D ++                 + +L+ +  + +Q +    VK+
Sbjct: 1109 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1168

Query: 410  HEQAK-------------------RNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQAS 450
             E  K                   R+   +I+N + E +     +   E ER  Y+ +  
Sbjct: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228

Query: 451  DLT------QKVLMNMEDIKVRETQIFDYRK-KIAESEIKLKQQQNLYEAVRSDRNLYSK 503
            +L       QK L +     VR+ +  +  K ++ E+  KL+ +QN  + V  D +   +
Sbjct: 1229 ELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1288

Query: 504  NLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQK 563
            +L   Q +I        ++ +     + + S KE+  V L+    ++++  + +  +L K
Sbjct: 1289 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1348

Query: 564  LRQ--QALE 570
             ++  Q LE
Sbjct: 1349 EKEHYQVLE 1357



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 83/429 (19%), Positives = 187/429 (43%), Gaps = 67/429 (15%)

Query: 3    EEKGGKQVLEESAFEEMERDFQG---VLHELSGDKSLEKFRIE------YERLHA----- 48
            +EK  +    E+  +E E D      +L ++  +  L K +IE      Y++  +     
Sbjct: 936  KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE 995

Query: 49   -VMKKSYDNEKRLMAKCRELNA--EIVVNSAKVATALKLSQ-DDQTTIASLKKEIEKAWK 104
             ++K   + EK +     EL++  + V +  K    L+    +    +AS +K ++   K
Sbjct: 996  ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD--K 1053

Query: 105  MVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQH--------------SNIRD 150
            +  ++ +++Q+ +   L  KE +  L   V   S LS  +               ++  +
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113

Query: 151  LLRFKEEVTKERDQLLS----EVVKLRESLAQTTEQQQETERSKEEAEH----AISQFQQ 202
             ++  E   KE D++ +    E  K +  LA+T    Q+ +RS E+ E+     + +  +
Sbjct: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173

Query: 203  EIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
             I+Q Q+  +   ++ E+L  E K    D+++ + E + L+  ++K++ E      +++E
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENK----DIENLRREREHLEMELEKAEMERSTYVTEVRE 1229

Query: 263  QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLD 322
             K L     K+L+      ++  ++NE+ +L+  QL+    +   +L+ ++ E  ++  D
Sbjct: 1230 LKDLLTELQKKLDD---SYSEAVRQNEELNLLKAQLN----ETLTKLRTEQNERQKVAGD 1282

Query: 323  IGKLNKIREQIHKKLHHT--------------EDQKAEVEQHKETLKNQIVGLEREVEAS 368
            + K  +  E I  K+                 E + +E E    +L   +  L++ ++A 
Sbjct: 1283 LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1342

Query: 369  KKQAELDRK 377
             +Q   +++
Sbjct: 1343 NQQLTKEKE 1351


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  130 bits (327), Expect = 5e-30
 Identities = 186/929 (20%), Positives = 400/929 (43%), Gaps = 122/929 (13%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL 60
            + +EK G  V++++  +  + +   ++H+L           E ++L A +K+     K  
Sbjct: 307  LLKEKSG--VIQDALKKSSKGELTTLIHQLQ----------EKDKLLAAVKEDAAATKD- 353

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
              +C++L  E++    +    +   +D    I +L+KE       +  +Y + Q+ +   
Sbjct: 354  --RCKQLTQEMMTEKERSNVVITRMKD---RIGTLEKEHNVFQNKIHVSYQETQQMQMKF 408

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT 180
              ++E++      ++Q +G+  D  SN  + L  K+    E ++L  +  +L   L + T
Sbjct: 409  QQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA--ELNKLRQDYARLVNELTEKT 466

Query: 181  EQQQETERSKEEAEHAISQFQQEIQQ--RQNEASREFRKKEKLEKELKQ--IQADMDSRQ 236
             + Q+ E  K+ AE A +Q + ++Q+  R+ E  + + +K   E E  Q  +Q+   +++
Sbjct: 467  GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526

Query: 237  TEIKALQQYVQKSKEELQKLEQQL-----KEQKILNERAAKE------LEQFQMRNAKLQ 285
             E+++L   +  +    Q+LEQ+L      EQK +N+  + +      LEQ +   A++Q
Sbjct: 527  NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586

Query: 286  QENEQ--------------HSLVCE---QLSQENQQKALE---LKAKEEEVHQMRLDIGK 325
            Q + Q              H ++ E   Q+ Q     A E   L +KEEE+     DI  
Sbjct: 587  QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK----DIQN 642

Query: 326  LNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRE 385
            +N + +   +KL    +++A      E ++  +   + ++   ++Q + +   +   + E
Sbjct: 643  MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE---ISNKMEE 699

Query: 386  RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHL------- 438
              ILN       +  QK   LV   EQ  +++  +++    E  ++ K +  L       
Sbjct: 700  FKILNDQNKALKSEVQKLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757

Query: 439  ----EKERDRYINQASDLTQKVLMNMEDIKVRETQ-------IFDYRKKIAESEIKLKQQ 487
                E+E +    + S LT++V    +D+K ++         + + +K I E + K+K  
Sbjct: 758  VATKEEELNAIRTENSSLTKEV----QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813

Query: 488  QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQ 547
            + L EA           +   +  + D+K+++K +  ++  ++ + + + S   K+  E 
Sbjct: 814  EELLEAELL-------KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-EL 865

Query: 548  QRIEKEKE----TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKEL 603
            Q + K KE    T+KA L++  +    T  +++  + E   L   + E     L++    
Sbjct: 866  QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925

Query: 604  DQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLR 663
             Q   E +I+   L  + +EL  L   +K ++S L+          ++ ++ + +I++L+
Sbjct: 926  SQ-FEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 981

Query: 664  REKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNA 723
            ++    A S    EEL +     ++E+        +L++ +E     H+ +K        
Sbjct: 982  QQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE-----HQRKKNNDLREKN 1036

Query: 724  YELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRT 783
            +E ++ + + +K L  K  +  ++    Q+ E + +E K VL +     +      Y   
Sbjct: 1037 WEAMEALASTEKMLQDKVNKTSKERQ--QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEW 1094

Query: 784  LH--DKK-----------QQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQK 830
            LH  +KK           +++KVL  +L   +      + E EK  + L   +      +
Sbjct: 1095 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1154

Query: 831  RKEQLQKNKDTAPMDNTFLMVKPNGPGFT 859
            R  + ++NK    +D +   +K     FT
Sbjct: 1155 RSVEQEENKWKVKVDESHKTIKQMQSSFT 1183



 Score =  100 bits (250), Expect = 4e-21
 Identities = 145/704 (20%), Positives = 313/704 (44%), Gaps = 69/704 (9%)

Query: 37   EKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLK 96
            +K R+  E+L   +    +  K L  + + L +E+     K+ T +   Q ++  +  ++
Sbjct: 680  DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV----QKLQTLVS-EQPNKDVVEQME 734

Query: 97   KEIEK-------AWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIR 149
            K I++         +++++   +    +E + A++ E  +LTK V+       DQ S   
Sbjct: 735  KCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS-FA 793

Query: 150  DLLRFKEEVTKERDQLLSEVVKLRES-LAQTTEQQQETERSKEEAEHAISQFQQEIQQRQ 208
             L+   ++V  E+D  +  V +L E+ L +   +++  +  K+E    I   ++EI   Q
Sbjct: 794  SLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQE----IKALKEEIGNVQ 849

Query: 209  NEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNE 268
             E +++     K++ EL+ +    + +   +KA+ +  +K      K  Q L+E+    +
Sbjct: 850  LEKAQQLSITSKVQ-ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLK 908

Query: 269  RAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVH-----QMRLDI 323
               +E+ Q  ++ A    + E+  +V ++  +EN+ K LE   KE E       Q+  D+
Sbjct: 909  AHVQEVAQHNLKEASSASQFEELEIVLKE--KENELKRLEAMLKERESDLSSKTQLLQDV 966

Query: 324  GKLNKI-REQIHKKLHHTEDQKAEVEQHKETLK------NQIVGLEREVEASKKQAELDR 376
               NK+ + QI +       Q +    H+E LK       +I GL  E+++ K   E  R
Sbjct: 967  QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQR 1026

Query: 377  KAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIF 436
            K  ++L RE+   N   ++A+ +T+K     K+++ +K   + +++  + EA++  K +F
Sbjct: 1027 KKNNDL-REK---NWEAMEALASTEKMLQ-DKVNKTSKERQQ-QVEAVELEAKEVLKKLF 1080

Query: 437  HLEKERDRYINQASDLTQKVLMNMEDIKVRETQI-FDYRKKIAESEIKLKQQQNLYEAVR 495
                     ++  S+L+    ++  + K +E        +++   E KLK+   ++  ++
Sbjct: 1081 PK-------VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1133

Query: 496  SDRNLYSKNLVEAQDEITDMKRKLKIMIHQ----VDELKEDISAKESALVKLHLEQQRIE 551
             +   Y   L E +  +  ++R ++   ++    VDE  + I   +S+      E +R+ 
Sbjct: 1134 LECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLR 1193

Query: 552  KEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERD 611
             E +    +++ LR++    +  +EK E E    +  + E        +K+LD   SE  
Sbjct: 1194 SENK----DIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSE-- 1247

Query: 612  ILGSQLVRRNDELALL-------YEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRR 664
                  VR+N+EL LL         K++ +Q+   K     ++  + + +++ +I K   
Sbjct: 1248 -----AVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1302

Query: 665  EKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPL 708
            +  ++  S  + E    E   M   L +  T+ + L + +   L
Sbjct: 1303 DTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1346



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 129/609 (21%), Positives = 256/609 (42%), Gaps = 105/609 (17%)

Query: 59   RLMAKCRELNAEIVVNSA--KVATALKLSQDDQTTIASLKKEIEKAW-------KMVDSA 109
            ++  K  ELNA    NS+  K    LK  Q+DQ + ASL +E++K         K V+  
Sbjct: 757  QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816

Query: 110  YDKE-----------QKAKETILALKEEIVNLTKLVEQGSGLSMDQH-SNIRDLLRFKEE 157
             + E           Q  K+ I ALKEEI N+   +E+   LS+      +++LL+ KEE
Sbjct: 817  LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ--LEKAQQLSITSKVQELQNLLKGKEE 874

Query: 158  VTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASR---- 213
                   +L E  K    LA T +  Q+ +   E  +  + +  Q   +  + AS+    
Sbjct: 875  QMNTMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL 931

Query: 214  EFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE 273
            E   KEK E ELK+++A +  R++++ +  Q +Q  ++E +  + Q+++ K  N + A  
Sbjct: 932  EIVLKEK-ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 990

Query: 274  LEQFQMRNAKLQQENEQHSLVCEQLS------QENQQKALELKAKEEEVHQMRLDIGKLN 327
                +     + +  ++ S +  +L       +  ++K  +L+ K  E  +      K+ 
Sbjct: 991  FPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM- 1049

Query: 328  KIREQIHKKLHHTEDQKAEVE-QHKETLKNQ---------------IVGLEREVEA--SK 369
             ++++++K     + Q   VE + KE LK                 + G E++ +   + 
Sbjct: 1050 -LQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAG 1108

Query: 370  KQAELDRKAMDELLRERDILN-----------------KNMLKAVNATQKQTD---LVKL 409
                 + K ++  L+E D ++                 + +L+ +  + +Q +    VK+
Sbjct: 1109 TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1168

Query: 410  HEQAK-------------------RNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQAS 450
             E  K                   R+   +I+N + E +     +   E ER  Y+ +  
Sbjct: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228

Query: 451  DLT------QKVLMNMEDIKVRETQIFDYRK-KIAESEIKLKQQQNLYEAVRSDRNLYSK 503
            +L       QK L +     VR+ +  +  K ++ E+  KL+ +QN  + V  D +   +
Sbjct: 1229 ELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQ 1288

Query: 504  NLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQK 563
            +L   Q +I        ++ +     + + S KE+  V L+    ++++  + +  +L K
Sbjct: 1289 SLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK 1348

Query: 564  LRQ--QALE 570
             ++  Q LE
Sbjct: 1349 EKEHYQVLE 1357



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 83/429 (19%), Positives = 187/429 (43%), Gaps = 67/429 (15%)

Query: 3    EEKGGKQVLEESAFEEMERDFQG---VLHELSGDKSLEKFRIE------YERLHA----- 48
            +EK  +    E+  +E E D      +L ++  +  L K +IE      Y++  +     
Sbjct: 936  KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE 995

Query: 49   -VMKKSYDNEKRLMAKCRELNA--EIVVNSAKVATALKLSQ-DDQTTIASLKKEIEKAWK 104
             ++K   + EK +     EL++  + V +  K    L+    +    +AS +K ++   K
Sbjct: 996  ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD--K 1053

Query: 105  MVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQH--------------SNIRD 150
            +  ++ +++Q+ +   L  KE +  L   V   S LS  +               ++  +
Sbjct: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113

Query: 151  LLRFKEEVTKERDQLLS----EVVKLRESLAQTTEQQQETERSKEEAEH----AISQFQQ 202
             ++  E   KE D++ +    E  K +  LA+T    Q+ +RS E+ E+     + +  +
Sbjct: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173

Query: 203  EIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
             I+Q Q+  +   ++ E+L  E K    D+++ + E + L+  ++K++ E      +++E
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENK----DIENLRREREHLEMELEKAEMERSTYVTEVRE 1229

Query: 263  QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLD 322
             K L     K+L+      ++  ++NE+ +L+  QL+    +   +L+ ++ E  ++  D
Sbjct: 1230 LKDLLTELQKKLDD---SYSEAVRQNEELNLLKAQLN----ETLTKLRTEQNERQKVAGD 1282

Query: 323  IGKLNKIREQIHKKLHHT--------------EDQKAEVEQHKETLKNQIVGLEREVEAS 368
            + K  +  E I  K+                 E + +E E    +L   +  L++ ++A 
Sbjct: 1283 LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1342

Query: 369  KKQAELDRK 377
             +Q   +++
Sbjct: 1343 NQQLTKEKE 1351


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  130 bits (326), Expect = 7e-30
 Identities = 196/1004 (19%), Positives = 402/1004 (40%), Gaps = 205/1004 (20%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKS------YDN 56
            E++G +   E     +   D +  L E   + + +K ++E     A +KK        D+
Sbjct: 935  EDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992

Query: 57   EKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA 116
            +   ++K R+L  E +   + + T L   ++    +  LK + E     ++    KE+K+
Sbjct: 993  QNNKLSKERKLLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 117  KETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL----LRFKEEVTKERDQLLSEVVKL 172
            ++ +  LK ++           G + D H  I DL       K ++ K+ ++L + + +L
Sbjct: 1050 RQELEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 173  RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
             + +AQ     ++      E E  IS  Q+++   +   ++  ++K  L +EL+ ++ ++
Sbjct: 1100 DDEIAQKNNALKKIR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 233  DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE---------------LEQF 277
            +         Q+   K ++E+  L++ L E+   +E   +E               LEQF
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215

Query: 278  QMRNAKLQQ-----ENEQHSLVCE-----QLSQENQQKALELKAKEEE------------ 315
            +   A L +     E E   L  E     Q  QE + K  +L+A+ +E            
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275

Query: 316  ------VHQMRLDI-----------GKLNKIREQI---HKKLHHTEDQKAEVEQHKETLK 355
                  VH+++ ++           GK  K+ + +     +L  T++   E  + K  + 
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335

Query: 356  NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKR 415
             ++  LE E  + + Q + + +A   L R    LN  +  +    Q     V+  E+ K+
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 416  NLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT------QKVLMNMEDIKVRETQ 469
              + EI+N   + +++      LEK ++R   +  DL       ++++ N+E  + +  Q
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 470  IFDYRKKI----------AESEIKLKQQQNLY------EAVRSDRNLYSKN--------- 504
            +    K I          AE+E + K+ + L       EA+ +   L   N         
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 505  LVEAQD-------EITDMKRKLKIMIH----QVDELKEDISAKESALVKLHLEQQRI--- 550
            LV ++D       E+   KR L+  +     Q++EL++++ A E A ++L +  Q +   
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 551  -EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
             E++ +    + ++ R+Q     H  E +  +ERK   + A A       KK+L+  + +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA-------KKKLEGDLKD 1628

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGIL 669
             ++     ++  +E      K++ Q          + + LED R  R EI    +E    
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMK-------DFQRELEDARASRDEIFATAKENEKK 1681

Query: 670  ARSM-ANVEELRQEFFHMQR----------ELLKE------------------RTRCRAL 700
            A+S+ A++ +L+++    +R          EL +E                    R   L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 701  EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYME 760
            EEELE          +EA      +  Q+   L   L ++     + E   Q+ E+   E
Sbjct: 1742 EEELEEEQG-----NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 761  LKHVLARQPGP------------------------EAAEQLKLYRRTLHDKKQQLKVLSS 796
            L+  L    G                         + A + +   ++L  K ++LK +  
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 797  ELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQKNK 839
            ++      +++YK + EK    ++ LK++   A++  +++  N+
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900



 Score =  122 bits (306), Expect = 1e-27
 Identities = 142/706 (20%), Positives = 310/706 (43%), Gaps = 53/706 (7%)

Query: 33   DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTI 92
            DK+ +    E   L   ++     ++ +  K ++L A++    +K +   +   +    +
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282

Query: 93   ASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLL 152
              L+ E+E    M++ A  K  K  + + +L  ++ +  +L+++ +   ++  + +R L 
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL- 1341

Query: 153  RFKEEVTKERDQLLSE----------VVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ 202
              +EE    +DQL  E          +  L   L+ + ++ Q+   + E  E    +FQ+
Sbjct: 1342 --EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 203  EIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
            EI+    +   +    +KLEK   ++Q ++D    ++   +Q V   +++ +K +Q L E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 263  QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQM-RL 321
            +K ++ + A E ++ +       +E E  +L   +  +E    ALE K + E  ++M + 
Sbjct: 1460 EKNISSKYADERDRAEAE----AREKETKALSLARALEE----ALEAKEELERTNKMLKA 1511

Query: 322  DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEAS------------- 368
            ++  L   ++ + K +H  E  K  +E   E +K Q+  LE E++A+             
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 369  -KKQAELDRKAMDELLRE-RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKD 426
             K Q E D +A DE   E R  L + + +     + +     L   AK+ LEG++++ + 
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 427  EAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ 486
            +A    K      K+  +   Q  D  ++    +ED +    +IF   K   E+E K K 
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRE----LEDARASRDEIFATAK---ENEKKAKS 1684

Query: 487  QQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
             +     ++ D     +   +A  E  ++  +L   +   + L+++    E+ + +L  E
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 547  QQRIEKEKETLKAELQKLRQQA--LETKHFIEKQEAEERKLLRIIAEADGERLRQK-KEL 603
             +  +   E +   ++K  QQA  L  +   E+  A++ +  R   E   + LR K  E+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1804

Query: 604  DQVISERDILGSQLVRRNDELALLYEKIK---IQQSVLNKGESQYNQRLEDMRI-LRLEI 659
            +  +  +    S +     ++A L E+++    ++    K   Q +++L+++ + +  E 
Sbjct: 1805 EGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862

Query: 660  KKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELE 705
            K   + K    +  A V++L+++    + E  +     R L+ EL+
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908



 Score =  119 bits (297), Expect = 2e-26
 Identities = 162/737 (21%), Positives = 329/737 (44%), Gaps = 99/737 (13%)

Query: 157  EVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQE--IQQRQNEASRE 214
            +VT++ +++ ++     + L +T E+QQ+ E   +E E   SQ  +E  + Q Q +A  E
Sbjct: 846  QVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 215  F------------RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
                          KK++LE+ L +++A ++  +   + LQ   +K  +++  LE+QL+E
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 263  QKILNERAAKELEQFQMRNAKLQQE-----------NEQHSLVCEQLSQ------ENQQK 305
            ++   ++   E    + +  KL+ E           +++  L+ E++S       E ++K
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 306  A---LELKAKEEE-VHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGL 361
            A    +LK K E  + ++ + + K  K R+++ K     E   ++  +    L+ QI   
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-- 1079

Query: 362  EREVEASKKQAELD---RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLH------EQ 412
            E +++ +KK+ EL     +  DE+ ++ + L K      + +  Q DL          E+
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             KR+L  E++  K E +         ++ R +   + + L + +    E+ +  E Q+ +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL---DEETRSHEAQVQE 1196

Query: 473  YRKKIAESEIKLKQQQNLYEAVRS--DRN---LYSKN---------LVEAQDEITDMKRK 518
             R+K A++  +L +Q   ++  ++  D+N   L  +N         L +A+ E+   K+K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 519  LKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ 578
            L+    QV EL+   S  E A  +L+ +  +++ E E++   L +   +A++    +   
Sbjct: 1257 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 579  EAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVL 638
             ++ +    ++ E   ++L    +L Q+  ER+ L  QL    DE     + ++   S L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL----DEEMEAKQNLERHISTL 1369

Query: 639  NKGESQYNQRLEDM--RILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLK-ERT 695
            N   S   ++L+D    +  LE  K R +K         +E L Q++        K E+T
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQK--------EIENLTQQYEEKAAAYDKLEKT 1421

Query: 696  RCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISK-TEEVVEKELLLQEK 754
            + R  +E  +  +++   R+L ++         ++   +K + SK  +E    E   +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 755  EKLYMELKHVLARQPGPEAAEQLKLYRRTL-----------HDKKQQLKVLSSELNMYEV 803
            E   + L   L  +   EA E+L+   + L            D  + +  L       E 
Sbjct: 1482 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 804  QSKEYKYEVEKLTNELQ 820
            Q +E K ++E+L +ELQ
Sbjct: 1540 QMEEMKTQLEELEDELQ 1556



 Score =  117 bits (293), Expect = 5e-26
 Identities = 167/885 (18%), Positives = 371/885 (41%), Gaps = 91/885 (10%)

Query: 12   EESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEI 71
            + S F E   D Q  + EL     L K   E +   A +      +   + K REL   I
Sbjct: 1063 DASDFHEQIADLQAQIAELK--MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120

Query: 72   V-----VNSAKVAT--ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALK 124
                  ++S + A   A K  +D    + +LK E+E       +  +   K ++ +  LK
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180

Query: 125  EEIVNLTKLVEQGSGLSMDQHSN-IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQ 183
            + +   T+  E        +H+  + +L    E+  + +  L      L +  A    + 
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 184  QETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQ 243
            +   ++K+E EH   + + ++Q+ Q++ S   R + +L  ++ ++Q +++S    +   +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 244  QYVQKSKEELQKLEQQLKE-QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQEN 302
                K  +++  L  QL++ Q++L E   ++L      + KL+Q  E+ + + +QL +E 
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV----STKLRQLEEERNSLQDQLDEEM 1356

Query: 303  QQKA----------LELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAE------ 346
            + K           ++L   ++++      +  L + +++  K++ +   Q  E      
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416

Query: 347  -VEQHKETLKNQIVGLEREVEASKK---QAELDRKAMDELLRERDILNKNMLKA-----V 397
             +E+ K  L+ ++  L  +++  ++     E  ++  D+LL E   ++            
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
             A +K+T  + L    +  LE      K+E ++  K+   L+ E +  ++   D+ + V 
Sbjct: 1477 EAREKETKALSLARALEEALEA-----KEELERTNKM---LKAEMEDLVSSKDDVGKNVH 1528

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQN----LYEAVRSDRNLYSKNLVEAQDEIT 513
               +  +  ETQ+ + + ++ E E +L+  ++    L   +++ +  + ++L    ++  
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 514  DMKRKLKIMIHQVDELKED--------ISAK---ESALVKLHLEQQRIEKEKETLKAELQ 562
            + +R+L+  +H+ +   ED         +AK   E  L  L L+     K +E    +L+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 563  KLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRND 622
            KL+ Q  + +  +E   A   ++     E   E+  +  E D +  + D+  ++  R+  
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKE--NEKKAKSLEADLMQLQEDLAAAERARKQA 1706

Query: 623  ELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            +L       ++  S+  +   Q  +R  + RI +LE ++L  E+G +      V +  Q+
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE-EELEEEQGNMEAMSDRVRKATQQ 1765

Query: 683  FFHMQRELLKERTRCRALE---EELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLIS 739
               +  EL  ER+  +  E   ++LE      R +  E       +    I  L+ ++  
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825

Query: 740  KTEEVVE-------------------KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY 780
              E+V +                   KE+LLQ +++  M  ++    + G    +QLK  
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK-- 1883

Query: 781  RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKK 825
             R L + +++ + +++     + +  E     E +  E+  LK K
Sbjct: 1884 -RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score =  114 bits (285), Expect = 4e-25
 Identities = 159/871 (18%), Positives = 363/871 (41%), Gaps = 83/871 (9%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            +Q   E+  +E+E+       +L+ +K+L + +++ E    +  ++ +   RL AK +EL
Sbjct: 867  RQQKAENELKELEQKHS----QLTEEKNLLQEQLQAET--ELYAEAEEMRVRLAAKKQEL 920

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
               +    A+    L+  +D    + + +K++ +    ++   ++E+ A++ +   K   
Sbjct: 921  EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
                K +E    L MD  +N         +++KER  L   +  L  +LA+  E+ +   
Sbjct: 977  EAKIKKLEDEI-LVMDDQNN---------KLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 188  RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
            + K + E  IS+ +  +++ +       + K KLE +       +   Q +I  L+  + 
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 248  KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            K +EELQ    +L ++      A K++ + +   + LQ++ +       +  ++ +    
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 308  ELKAKEEEVHQMRLDIGKLNKIREQIHKKL--------HHTEDQKAEVEQHKETLKNQIV 359
            EL+A + E+           ++R +  +++          T   +A+V++ ++     + 
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 360  GLEREVEASKK-QAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLE 418
             L  ++E  K+ +A LD+          D+  +  L+ +   +++       E  K+ LE
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE--LRVLGQAKQEV------EHKKKKLE 1258

Query: 419  GEIQNYKDEAQKQRKI-------IFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIF 471
             ++Q  + +     +        +  L+ E +      ++   K +   +D+    +Q+ 
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 472  DYRKKIAES-------EIKLKQ--------QQNLYEAVRSDRNLYSKNLVEAQDEITDMK 516
            D ++ + E          KL+Q        Q  L E + + +NL  +++     +++D K
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK 1377

Query: 517  RKLKIMIHQVDELKEDISAKESALVKLHLEQQ-------RIEKEKETLKAELQKLRQQAL 569
            +KL+     V+ L+E     +  +  L  + +       ++EK K  L+ EL  L     
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 570  ETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV---ISERDILGSQLVRRNDELAL 626
              +  +   E ++RK  +++AE      +   E D+      E++     L R  +E   
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497

Query: 627  LYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSM-ANVEELRQEFFH 685
              E+++    +L           +D+     E++K +R        M   +EEL  E   
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557

Query: 686  MQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVV 745
             +   L+     +AL+ + E  L      + E ++    +L +++H  +  L    +E  
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQLQRQLHEYETEL---EDERK 1610

Query: 746  EKELLLQEKEKLYMELKHV-----LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNM 800
            ++ L    K+KL  +LK +      A +   EA +QL+  +  + D +++L+   +  + 
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1670

Query: 801  YEVQSKEYKYEVEKLTNELQNLKKKYLAQKR 831
                +KE + + + L  +L  L++   A +R
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAER 1701



 Score =  114 bits (284), Expect = 5e-25
 Identities = 145/669 (21%), Positives = 296/669 (44%), Gaps = 100/669 (14%)

Query: 197  ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
            +++ ++E+Q +++E  +   +++K E ELK+              L+Q   +  EE   L
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKAENELKE--------------LEQKHSQLTEEKNLL 892

Query: 257  EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++QL+ +  L      E E+ ++R A  +QE E+     E   +E + +  +L+A+ +++
Sbjct: 893  QEQLQAETEL----YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 317  HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREV---EASKKQAE 373
             Q  LD          + ++L   E  + +++  K T + +I  LE E+   +    +  
Sbjct: 949  AQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 374  LDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
             +RK ++E + +   L  N+ +     +  T L   HE     LE  ++  K+E  +Q  
Sbjct: 999  KERKLLEERISD---LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--KEEKSRQ-- 1051

Query: 434  IIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL-KQQQNLYE 492
                LEK + +    ASD  +              QI D + +IAE +++L K+++ L  
Sbjct: 1052 ---ELEKLKRKLEGDASDFHE--------------QIADLQAQIAELKMQLAKKEEELQA 1094

Query: 493  AV-RSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIE 551
            A+ R D  +  KN         +  +K++ +   + +L+ED+ ++ +A  K   +++ + 
Sbjct: 1095 ALARLDDEIAQKN---------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145

Query: 552  KEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERD 611
            +E E LK EL+         +    K+E E   L + + E       Q +E+ Q      
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------ 1199

Query: 612  ILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED----MRILRLEIKKLRREKG 667
                +  +  +EL    E+ K  ++ L+K +    +   D    +R+L    +++  +K 
Sbjct: 1200 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 668  ILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
             L    A V+EL+ +    +R   +   +   L+ E+E+   +     L  ++  A +L 
Sbjct: 1256 KLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-----LNEAEGKAIKLA 1307

Query: 728  QKIHTLQKRLISKTEEVVEKE----LLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRR- 782
            + + +L  +L   T+E++++E    L +  K +   E ++ L  Q   E   +  L R  
Sbjct: 1308 KDVASLSSQL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366

Query: 783  -----TLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQ 836
                  L D K++L+  +S +   E   K ++ E+E LT + +     Y   +K K +LQ
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426

Query: 837  KNKDTAPMD 845
            +  D   +D
Sbjct: 1427 QELDDLVVD 1435



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 69/307 (22%), Positives = 138/307 (44%), Gaps = 34/307 (11%)

Query: 5    KGGKQVLEE-SAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAK 63
            KG ++ +++    +   +DFQ         + LE  R   + + A  K   +NEK    K
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQ---------RELEDARASRDEIFATAK---ENEK----K 1681

Query: 64   CRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILAL 123
             + L A+++     +A A +  +        L +E+  +    ++  D++++ +  I  L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 124  KEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQ 183
            +EE+       EQG+  +M     +R   +  E+++ E     S   K  ES  Q  E+Q
Sbjct: 1742 EEELEE-----EQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQK-NESARQQLERQ 1793

Query: 184  QETERSK-EEAEHA--------ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS 234
             +  RSK  E E A        I+  + +I Q + +  +E R+K+   K LKQ    +  
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853

Query: 235  RQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLV 294
               +++  ++  ++ KE+ +K   ++K+ K   E A +E ++      KLQ+E ++ +  
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913

Query: 295  CEQLSQE 301
             E + +E
Sbjct: 1914 NEAMGRE 1920



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 59/259 (22%), Positives = 121/259 (46%), Gaps = 25/259 (9%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSL--EKFRIEYE--RLHAVMKKSYDN 56
            + E+    +   + A  E E   + +   LSG  +L  EK R+E    +L   +++   N
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751

Query: 57   EKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEI-EKAWKMVDSAYDKEQK 115
             + +  + R+   +    S ++AT    +Q +++    L+++  E   K+ +     + K
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811

Query: 116  AKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRES 175
             K TI AL+ +I  L + VEQ +              R K+  TK   Q   +  KL+E 
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEA--------------REKQAATKSLKQ---KDKKLKEI 1854

Query: 176  LAQTTEQQQETERSKEEAEHA---ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
            L Q  ++++  E+ KE+AE     + Q ++++++ + E+ R    + KL++EL +     
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1914

Query: 233  DSRQTEIKALQQYVQKSKE 251
            ++   E+ AL+  +++  E
Sbjct: 1915 EAMGREVNALKSKLRRGNE 1933


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  130 bits (326), Expect = 7e-30
 Identities = 196/1004 (19%), Positives = 402/1004 (40%), Gaps = 205/1004 (20%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKS------YDN 56
            E++G +   E     +   D +  L E   + + +K ++E     A +KK        D+
Sbjct: 942  EDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999

Query: 57   EKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA 116
            +   ++K R+L  E +   + + T L   ++    +  LK + E     ++    KE+K+
Sbjct: 1000 QNNKLSKERKLLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 117  KETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL----LRFKEEVTKERDQLLSEVVKL 172
            ++ +  LK ++           G + D H  I DL       K ++ K+ ++L + + +L
Sbjct: 1057 RQELEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 173  RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
             + +AQ     ++      E E  IS  Q+++   +   ++  ++K  L +EL+ ++ ++
Sbjct: 1107 DDEIAQKNNALKKIR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 233  DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE---------------LEQF 277
            +         Q+   K ++E+  L++ L E+   +E   +E               LEQF
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222

Query: 278  QMRNAKLQQ-----ENEQHSLVCE-----QLSQENQQKALELKAKEEE------------ 315
            +   A L +     E E   L  E     Q  QE + K  +L+A+ +E            
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282

Query: 316  ------VHQMRLDI-----------GKLNKIREQI---HKKLHHTEDQKAEVEQHKETLK 355
                  VH+++ ++           GK  K+ + +     +L  T++   E  + K  + 
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342

Query: 356  NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKR 415
             ++  LE E  + + Q + + +A   L R    LN  +  +    Q     V+  E+ K+
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 416  NLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT------QKVLMNMEDIKVRETQ 469
              + EI+N   + +++      LEK ++R   +  DL       ++++ N+E  + +  Q
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 470  IFDYRKKI----------AESEIKLKQQQNLY------EAVRSDRNLYSKN--------- 504
            +    K I          AE+E + K+ + L       EA+ +   L   N         
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 505  LVEAQD-------EITDMKRKLKIMIH----QVDELKEDISAKESALVKLHLEQQRI--- 550
            LV ++D       E+   KR L+  +     Q++EL++++ A E A ++L +  Q +   
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 551  -EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
             E++ +    + ++ R+Q     H  E +  +ERK   + A A       KK+L+  + +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA-------KKKLEGDLKD 1635

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGIL 669
             ++     ++  +E      K++ Q          + + LED R  R EI    +E    
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMK-------DFQRELEDARASRDEIFATAKENEKK 1688

Query: 670  ARSM-ANVEELRQEFFHMQR----------ELLKE------------------RTRCRAL 700
            A+S+ A++ +L+++    +R          EL +E                    R   L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 701  EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYME 760
            EEELE          +EA      +  Q+   L   L ++     + E   Q+ E+   E
Sbjct: 1749 EEELEEEQG-----NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 761  LKHVLARQPGP------------------------EAAEQLKLYRRTLHDKKQQLKVLSS 796
            L+  L    G                         + A + +   ++L  K ++LK +  
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 797  ELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQKNK 839
            ++      +++YK + EK    ++ LK++   A++  +++  N+
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907



 Score =  122 bits (306), Expect = 1e-27
 Identities = 142/706 (20%), Positives = 310/706 (43%), Gaps = 53/706 (7%)

Query: 33   DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTI 92
            DK+ +    E   L   ++     ++ +  K ++L A++    +K +   +   +    +
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289

Query: 93   ASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLL 152
              L+ E+E    M++ A  K  K  + + +L  ++ +  +L+++ +   ++  + +R L 
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL- 1348

Query: 153  RFKEEVTKERDQLLSE----------VVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ 202
              +EE    +DQL  E          +  L   L+ + ++ Q+   + E  E    +FQ+
Sbjct: 1349 --EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 203  EIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
            EI+    +   +    +KLEK   ++Q ++D    ++   +Q V   +++ +K +Q L E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 263  QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQM-RL 321
            +K ++ + A E ++ +       +E E  +L   +  +E    ALE K + E  ++M + 
Sbjct: 1467 EKNISSKYADERDRAEAE----AREKETKALSLARALEE----ALEAKEELERTNKMLKA 1518

Query: 322  DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEAS------------- 368
            ++  L   ++ + K +H  E  K  +E   E +K Q+  LE E++A+             
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578

Query: 369  -KKQAELDRKAMDELLRE-RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKD 426
             K Q E D +A DE   E R  L + + +     + +     L   AK+ LEG++++ + 
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 427  EAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ 486
            +A    K      K+  +   Q  D  ++    +ED +    +IF   K   E+E K K 
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRE----LEDARASRDEIFATAK---ENEKKAKS 1691

Query: 487  QQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
             +     ++ D     +   +A  E  ++  +L   +   + L+++    E+ + +L  E
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 547  QQRIEKEKETLKAELQKLRQQA--LETKHFIEKQEAEERKLLRIIAEADGERLRQK-KEL 603
             +  +   E +   ++K  QQA  L  +   E+  A++ +  R   E   + LR K  E+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM 1811

Query: 604  DQVISERDILGSQLVRRNDELALLYEKIK---IQQSVLNKGESQYNQRLEDMRI-LRLEI 659
            +  +  +    S +     ++A L E+++    ++    K   Q +++L+++ + +  E 
Sbjct: 1812 EGAVKSK--FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869

Query: 660  KKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELE 705
            K   + K    +  A V++L+++    + E  +     R L+ EL+
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915



 Score =  119 bits (297), Expect = 2e-26
 Identities = 162/737 (21%), Positives = 329/737 (44%), Gaps = 99/737 (13%)

Query: 157  EVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQE--IQQRQNEASRE 214
            +VT++ +++ ++     + L +T E+QQ+ E   +E E   SQ  +E  + Q Q +A  E
Sbjct: 853  QVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 215  F------------RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
                          KK++LE+ L +++A ++  +   + LQ   +K  +++  LE+QL+E
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 263  QKILNERAAKELEQFQMRNAKLQQE-----------NEQHSLVCEQLSQ------ENQQK 305
            ++   ++   E    + +  KL+ E           +++  L+ E++S       E ++K
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 306  A---LELKAKEEE-VHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGL 361
            A    +LK K E  + ++ + + K  K R+++ K     E   ++  +    L+ QI   
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-- 1086

Query: 362  EREVEASKKQAELD---RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLH------EQ 412
            E +++ +KK+ EL     +  DE+ ++ + L K      + +  Q DL          E+
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             KR+L  E++  K E +         ++ R +   + + L + +    E+ +  E Q+ +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL---DEETRSHEAQVQE 1203

Query: 473  YRKKIAESEIKLKQQQNLYEAVRS--DRN---LYSKN---------LVEAQDEITDMKRK 518
             R+K A++  +L +Q   ++  ++  D+N   L  +N         L +A+ E+   K+K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 519  LKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ 578
            L+    QV EL+   S  E A  +L+ +  +++ E E++   L +   +A++    +   
Sbjct: 1264 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 579  EAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVL 638
             ++ +    ++ E   ++L    +L Q+  ER+ L  QL    DE     + ++   S L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL----DEEMEAKQNLERHISTL 1376

Query: 639  NKGESQYNQRLEDM--RILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLK-ERT 695
            N   S   ++L+D    +  LE  K R +K         +E L Q++        K E+T
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQK--------EIENLTQQYEEKAAAYDKLEKT 1428

Query: 696  RCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISK-TEEVVEKELLLQEK 754
            + R  +E  +  +++   R+L ++         ++   +K + SK  +E    E   +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 755  EKLYMELKHVLARQPGPEAAEQLKLYRRTL-----------HDKKQQLKVLSSELNMYEV 803
            E   + L   L  +   EA E+L+   + L            D  + +  L       E 
Sbjct: 1489 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 804  QSKEYKYEVEKLTNELQ 820
            Q +E K ++E+L +ELQ
Sbjct: 1547 QMEEMKTQLEELEDELQ 1563



 Score =  117 bits (293), Expect = 5e-26
 Identities = 167/885 (18%), Positives = 371/885 (41%), Gaps = 91/885 (10%)

Query: 12   EESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEI 71
            + S F E   D Q  + EL     L K   E +   A +      +   + K REL   I
Sbjct: 1070 DASDFHEQIADLQAQIAELK--MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127

Query: 72   V-----VNSAKVAT--ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALK 124
                  ++S + A   A K  +D    + +LK E+E       +  +   K ++ +  LK
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187

Query: 125  EEIVNLTKLVEQGSGLSMDQHSN-IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQ 183
            + +   T+  E        +H+  + +L    E+  + +  L      L +  A    + 
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 184  QETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQ 243
            +   ++K+E EH   + + ++Q+ Q++ S   R + +L  ++ ++Q +++S    +   +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 244  QYVQKSKEELQKLEQQLKE-QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQEN 302
                K  +++  L  QL++ Q++L E   ++L      + KL+Q  E+ + + +QL +E 
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV----STKLRQLEEERNSLQDQLDEEM 1363

Query: 303  QQKA----------LELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAE------ 346
            + K           ++L   ++++      +  L + +++  K++ +   Q  E      
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423

Query: 347  -VEQHKETLKNQIVGLEREVEASKK---QAELDRKAMDELLRERDILNKNMLKA-----V 397
             +E+ K  L+ ++  L  +++  ++     E  ++  D+LL E   ++            
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
             A +K+T  + L    +  LE      K+E ++  K+   L+ E +  ++   D+ + V 
Sbjct: 1484 EAREKETKALSLARALEEALEA-----KEELERTNKM---LKAEMEDLVSSKDDVGKNVH 1535

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQN----LYEAVRSDRNLYSKNLVEAQDEIT 513
               +  +  ETQ+ + + ++ E E +L+  ++    L   +++ +  + ++L    ++  
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 514  DMKRKLKIMIHQVDELKED--------ISAK---ESALVKLHLEQQRIEKEKETLKAELQ 562
            + +R+L+  +H+ +   ED         +AK   E  L  L L+     K +E    +L+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 563  KLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRND 622
            KL+ Q  + +  +E   A   ++     E   E+  +  E D +  + D+  ++  R+  
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKE--NEKKAKSLEADLMQLQEDLAAAERARKQA 1713

Query: 623  ELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            +L       ++  S+  +   Q  +R  + RI +LE ++L  E+G +      V +  Q+
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE-EELEEEQGNMEAMSDRVRKATQQ 1772

Query: 683  FFHMQRELLKERTRCRALE---EELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLIS 739
               +  EL  ER+  +  E   ++LE      R +  E       +    I  L+ ++  
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832

Query: 740  KTEEVVE-------------------KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY 780
              E+V +                   KE+LLQ +++  M  ++    + G    +QLK  
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK-- 1890

Query: 781  RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKK 825
             R L + +++ + +++     + +  E     E +  E+  LK K
Sbjct: 1891 -RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score =  114 bits (285), Expect = 4e-25
 Identities = 159/871 (18%), Positives = 363/871 (41%), Gaps = 83/871 (9%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            +Q   E+  +E+E+       +L+ +K+L + +++ E    +  ++ +   RL AK +EL
Sbjct: 874  RQQKAENELKELEQKHS----QLTEEKNLLQEQLQAET--ELYAEAEEMRVRLAAKKQEL 927

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
               +    A+    L+  +D    + + +K++ +    ++   ++E+ A++ +   K   
Sbjct: 928  EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
                K +E    L MD  +N         +++KER  L   +  L  +LA+  E+ +   
Sbjct: 984  EAKIKKLEDEI-LVMDDQNN---------KLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 188  RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
            + K + E  IS+ +  +++ +       + K KLE +       +   Q +I  L+  + 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 248  KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            K +EELQ    +L ++      A K++ + +   + LQ++ +       +  ++ +    
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 308  ELKAKEEEVHQMRLDIGKLNKIREQIHKKL--------HHTEDQKAEVEQHKETLKNQIV 359
            EL+A + E+           ++R +  +++          T   +A+V++ ++     + 
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 360  GLEREVEASKK-QAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLE 418
             L  ++E  K+ +A LD+          D+  +  L+ +   +++       E  K+ LE
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE--LRVLGQAKQEV------EHKKKKLE 1265

Query: 419  GEIQNYKDEAQKQRKI-------IFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIF 471
             ++Q  + +     +        +  L+ E +      ++   K +   +D+    +Q+ 
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 472  DYRKKIAES-------EIKLKQ--------QQNLYEAVRSDRNLYSKNLVEAQDEITDMK 516
            D ++ + E          KL+Q        Q  L E + + +NL  +++     +++D K
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK 1384

Query: 517  RKLKIMIHQVDELKEDISAKESALVKLHLEQQ-------RIEKEKETLKAELQKLRQQAL 569
            +KL+     V+ L+E     +  +  L  + +       ++EK K  L+ EL  L     
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 570  ETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV---ISERDILGSQLVRRNDELAL 626
              +  +   E ++RK  +++AE      +   E D+      E++     L R  +E   
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504

Query: 627  LYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSM-ANVEELRQEFFH 685
              E+++    +L           +D+     E++K +R        M   +EEL  E   
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564

Query: 686  MQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVV 745
             +   L+     +AL+ + E  L      + E ++    +L +++H  +  L    +E  
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQLQRQLHEYETEL---EDERK 1617

Query: 746  EKELLLQEKEKLYMELKHV-----LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNM 800
            ++ L    K+KL  +LK +      A +   EA +QL+  +  + D +++L+   +  + 
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1677

Query: 801  YEVQSKEYKYEVEKLTNELQNLKKKYLAQKR 831
                +KE + + + L  +L  L++   A +R
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAER 1708



 Score =  114 bits (284), Expect = 5e-25
 Identities = 145/669 (21%), Positives = 296/669 (44%), Gaps = 100/669 (14%)

Query: 197  ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
            +++ ++E+Q +++E  +   +++K E ELK+              L+Q   +  EE   L
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELKE--------------LEQKHSQLTEEKNLL 899

Query: 257  EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++QL+ +  L      E E+ ++R A  +QE E+     E   +E + +  +L+A+ +++
Sbjct: 900  QEQLQAETEL----YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 317  HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREV---EASKKQAE 373
             Q  LD          + ++L   E  + +++  K T + +I  LE E+   +    +  
Sbjct: 956  AQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 374  LDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
             +RK ++E + +   L  N+ +     +  T L   HE     LE  ++  K+E  +Q  
Sbjct: 1006 KERKLLEERISD---LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--KEEKSRQ-- 1058

Query: 434  IIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL-KQQQNLYE 492
                LEK + +    ASD  +              QI D + +IAE +++L K+++ L  
Sbjct: 1059 ---ELEKLKRKLEGDASDFHE--------------QIADLQAQIAELKMQLAKKEEELQA 1101

Query: 493  AV-RSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIE 551
            A+ R D  +  KN         +  +K++ +   + +L+ED+ ++ +A  K   +++ + 
Sbjct: 1102 ALARLDDEIAQKN---------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152

Query: 552  KEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERD 611
            +E E LK EL+         +    K+E E   L + + E       Q +E+ Q      
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------ 1206

Query: 612  ILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED----MRILRLEIKKLRREKG 667
                +  +  +EL    E+ K  ++ L+K +    +   D    +R+L    +++  +K 
Sbjct: 1207 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 668  ILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
             L    A V+EL+ +    +R   +   +   L+ E+E+   +     L  ++  A +L 
Sbjct: 1263 KLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-----LNEAEGKAIKLA 1314

Query: 728  QKIHTLQKRLISKTEEVVEKE----LLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRR- 782
            + + +L  +L   T+E++++E    L +  K +   E ++ L  Q   E   +  L R  
Sbjct: 1315 KDVASLSSQL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 783  -----TLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQ 836
                  L D K++L+  +S +   E   K ++ E+E LT + +     Y   +K K +LQ
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 837  KNKDTAPMD 845
            +  D   +D
Sbjct: 1434 QELDDLVVD 1442



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 69/307 (22%), Positives = 138/307 (44%), Gaps = 34/307 (11%)

Query: 5    KGGKQVLEE-SAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAK 63
            KG ++ +++    +   +DFQ         + LE  R   + + A  K   +NEK    K
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQ---------RELEDARASRDEIFATAK---ENEK----K 1688

Query: 64   CRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILAL 123
             + L A+++     +A A +  +        L +E+  +    ++  D++++ +  I  L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 124  KEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQ 183
            +EE+       EQG+  +M     +R   +  E+++ E     S   K  ES  Q  E+Q
Sbjct: 1749 EEELEE-----EQGNMEAMSDR--VRKATQQAEQLSNELATERSTAQK-NESARQQLERQ 1800

Query: 184  QETERSK-EEAEHA--------ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS 234
             +  RSK  E E A        I+  + +I Q + +  +E R+K+   K LKQ    +  
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860

Query: 235  RQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLV 294
               +++  ++  ++ KE+ +K   ++K+ K   E A +E ++      KLQ+E ++ +  
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920

Query: 295  CEQLSQE 301
             E + +E
Sbjct: 1921 NEAMGRE 1927



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 59/259 (22%), Positives = 121/259 (46%), Gaps = 25/259 (9%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSL--EKFRIEYE--RLHAVMKKSYDN 56
            + E+    +   + A  E E   + +   LSG  +L  EK R+E    +L   +++   N
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758

Query: 57   EKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEI-EKAWKMVDSAYDKEQK 115
             + +  + R+   +    S ++AT    +Q +++    L+++  E   K+ +     + K
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818

Query: 116  AKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRES 175
             K TI AL+ +I  L + VEQ +              R K+  TK   Q   +  KL+E 
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEA--------------REKQAATKSLKQ---KDKKLKEI 1861

Query: 176  LAQTTEQQQETERSKEEAEHA---ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
            L Q  ++++  E+ KE+AE     + Q ++++++ + E+ R    + KL++EL +     
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN 1921

Query: 233  DSRQTEIKALQQYVQKSKE 251
            ++   E+ AL+  +++  E
Sbjct: 1922 EAMGREVNALKSKLRRGNE 1940


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  130 bits (326), Expect = 7e-30
 Identities = 196/1004 (19%), Positives = 402/1004 (40%), Gaps = 205/1004 (20%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKS------YDN 56
            E++G +   E     +   D +  L E   + + +K ++E     A +KK        D+
Sbjct: 942  EDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999

Query: 57   EKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA 116
            +   ++K R+L  E +   + + T L   ++    +  LK + E     ++    KE+K+
Sbjct: 1000 QNNKLSKERKLLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 117  KETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL----LRFKEEVTKERDQLLSEVVKL 172
            ++ +  LK ++           G + D H  I DL       K ++ K+ ++L + + +L
Sbjct: 1057 RQELEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 173  RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
             + +AQ     ++      E E  IS  Q+++   +   ++  ++K  L +EL+ ++ ++
Sbjct: 1107 DDEIAQKNNALKKIR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 233  DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE---------------LEQF 277
            +         Q+   K ++E+  L++ L E+   +E   +E               LEQF
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222

Query: 278  QMRNAKLQQ-----ENEQHSLVCE-----QLSQENQQKALELKAKEEE------------ 315
            +   A L +     E E   L  E     Q  QE + K  +L+A+ +E            
Sbjct: 1223 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282

Query: 316  ------VHQMRLDI-----------GKLNKIREQI---HKKLHHTEDQKAEVEQHKETLK 355
                  VH+++ ++           GK  K+ + +     +L  T++   E  + K  + 
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342

Query: 356  NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKR 415
             ++  LE E  + + Q + + +A   L R    LN  +  +    Q     V+  E+ K+
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 416  NLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT------QKVLMNMEDIKVRETQ 469
              + EI+N   + +++      LEK ++R   +  DL       ++++ N+E  + +  Q
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 470  IFDYRKKI----------AESEIKLKQQQNLY------EAVRSDRNLYSKN--------- 504
            +    K I          AE+E + K+ + L       EA+ +   L   N         
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 505  LVEAQD-------EITDMKRKLKIMIH----QVDELKEDISAKESALVKLHLEQQRI--- 550
            LV ++D       E+   KR L+  +     Q++EL++++ A E A ++L +  Q +   
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 551  -EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
             E++ +    + ++ R+Q     H  E +  +ERK   + A A       KK+L+  + +
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA-------KKKLEGDLKD 1635

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGIL 669
             ++     ++  +E      K++ Q          + + LED R  R EI    +E    
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMK-------DFQRELEDARASRDEIFATAKENEKK 1688

Query: 670  ARSM-ANVEELRQEFFHMQR----------ELLKE------------------RTRCRAL 700
            A+S+ A++ +L+++    +R          EL +E                    R   L
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1748

Query: 701  EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYME 760
            EEELE          +EA      +  Q+   L   L ++     + E   Q+ E+   E
Sbjct: 1749 EEELEEEQG-----NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 761  LKHVLARQPGP------------------------EAAEQLKLYRRTLHDKKQQLKVLSS 796
            L+  L    G                         + A + +   ++L  K ++LK +  
Sbjct: 1804 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863

Query: 797  ELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQKNK 839
            ++      +++YK + EK    ++ LK++   A++  +++  N+
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907



 Score =  123 bits (309), Expect = 6e-28
 Identities = 162/780 (20%), Positives = 333/780 (42%), Gaps = 100/780 (12%)

Query: 33   DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTI 92
            DK+ +    E   L   ++     ++ +  K ++L A++    +K +   +   +    +
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1289

Query: 93   ASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLL 152
              L+ E+E    M++ A  K  K  + + +L  ++ +  +L+++ +   ++  + +R L 
Sbjct: 1290 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL- 1348

Query: 153  RFKEEVTKERDQLLSE----------VVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ 202
              +EE    +DQL  E          +  L   L+ + ++ Q+   + E  E    +FQ+
Sbjct: 1349 --EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 203  EIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
            EI+    +   +    +KLEK   ++Q ++D    ++   +Q V   +++ +K +Q L E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 263  QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQM-RL 321
            +K ++ + A E ++ +       +E E  +L   +  +E    ALE K + E  ++M + 
Sbjct: 1467 EKNISSKYADERDRAEAE----AREKETKALSLARALEE----ALEAKEELERTNKMLKA 1518

Query: 322  DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEAS------------- 368
            ++  L   ++ + K +H  E  K  +E   E +K Q+  LE E++A+             
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578

Query: 369  -KKQAELDRKAMDELLRE-RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKD 426
             K Q E D +A DE   E R  L + + +     + +     L   AK+ LEG++++ + 
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 427  EAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ 486
            +A    K      K+  +   Q  D  ++    +ED +    +IF   K   E+E K K 
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRE----LEDARASRDEIFATAK---ENEKKAKS 1691

Query: 487  QQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
             +               +L++ Q+++   +R  K    + +EL E++++  S        
Sbjct: 1692 LE--------------ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG------- 1730

Query: 547  QQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
            +  ++ EK  L+A + +L ++  E +  +E      RK  +   +   E   ++    + 
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 607  ISERDILGSQLVRRNDEL-ALLYE-------KIKIQQSVLNKGESQYNQRLE-DMRILRL 657
             S R     QL R+N EL + L+E       K K   + L    +Q  +++E + R  + 
Sbjct: 1791 ESAR----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 658  EIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLE 717
              K L+++   L   +  VE+ R+     + +  K   R + L+ +LE            
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE------------ 1894

Query: 718  ASDPNAYELIQKIHTLQKRLISKTEEVVE-KELLLQEKEKLYMELKHVLARQPGPEAAEQ 776
                 A E  Q+I+  +++L  + +E  E  E + +E   L  +L     R P P+   Q
Sbjct: 1895 ----EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL-----RGPPPQETSQ 1945



 Score =  119 bits (297), Expect = 2e-26
 Identities = 162/737 (21%), Positives = 329/737 (44%), Gaps = 99/737 (13%)

Query: 157  EVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQE--IQQRQNEASRE 214
            +VT++ +++ ++     + L +T E+QQ+ E   +E E   SQ  +E  + Q Q +A  E
Sbjct: 853  QVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908

Query: 215  F------------RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
                          KK++LE+ L +++A ++  +   + LQ   +K  +++  LE+QL+E
Sbjct: 909  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 263  QKILNERAAKELEQFQMRNAKLQQE-----------NEQHSLVCEQLSQ------ENQQK 305
            ++   ++   E    + +  KL+ E           +++  L+ E++S       E ++K
Sbjct: 969  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028

Query: 306  A---LELKAKEEE-VHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGL 361
            A    +LK K E  + ++ + + K  K R+++ K     E   ++  +    L+ QI   
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-- 1086

Query: 362  EREVEASKKQAELD---RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLH------EQ 412
            E +++ +KK+ EL     +  DE+ ++ + L K      + +  Q DL          E+
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             KR+L  E++  K E +         ++ R +   + + L + +    E+ +  E Q+ +
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL---DEETRSHEAQVQE 1203

Query: 473  YRKKIAESEIKLKQQQNLYEAVRS--DRN---LYSKN---------LVEAQDEITDMKRK 518
             R+K A++  +L +Q   ++  ++  D+N   L  +N         L +A+ E+   K+K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 519  LKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ 578
            L+    QV EL+   S  E A  +L+ +  +++ E E++   L +   +A++    +   
Sbjct: 1264 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 579  EAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVL 638
             ++ +    ++ E   ++L    +L Q+  ER+ L  QL    DE     + ++   S L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL----DEEMEAKQNLERHISTL 1376

Query: 639  NKGESQYNQRLEDM--RILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLK-ERT 695
            N   S   ++L+D    +  LE  K R +K         +E L Q++        K E+T
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQK--------EIENLTQQYEEKAAAYDKLEKT 1428

Query: 696  RCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISK-TEEVVEKELLLQEK 754
            + R  +E  +  +++   R+L ++         ++   +K + SK  +E    E   +EK
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 755  EKLYMELKHVLARQPGPEAAEQLKLYRRTL-----------HDKKQQLKVLSSELNMYEV 803
            E   + L   L  +   EA E+L+   + L            D  + +  L       E 
Sbjct: 1489 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546

Query: 804  QSKEYKYEVEKLTNELQ 820
            Q +E K ++E+L +ELQ
Sbjct: 1547 QMEEMKTQLEELEDELQ 1563



 Score =  117 bits (294), Expect = 4e-26
 Identities = 169/896 (18%), Positives = 374/896 (41%), Gaps = 91/896 (10%)

Query: 12   EESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEI 71
            + S F E   D Q  + EL     L K   E +   A +      +   + K REL   I
Sbjct: 1070 DASDFHEQIADLQAQIAELK--MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127

Query: 72   V-----VNSAKVAT--ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALK 124
                  ++S + A   A K  +D    + +LK E+E       +  +   K ++ +  LK
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187

Query: 125  EEIVNLTKLVEQGSGLSMDQHSN-IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQ 183
            + +   T+  E        +H+  + +L    E+  + +  L      L +  A    + 
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 184  QETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQ 243
            +   ++K+E EH   + + ++Q+ Q++ S   R + +L  ++ ++Q +++S    +   +
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 244  QYVQKSKEELQKLEQQLKE-QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQEN 302
                K  +++  L  QL++ Q++L E   ++L      + KL+Q  E+ + + +QL +E 
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV----STKLRQLEEERNSLQDQLDEEM 1363

Query: 303  QQKA----------LELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAE------ 346
            + K           ++L   ++++      +  L + +++  K++ +   Q  E      
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423

Query: 347  -VEQHKETLKNQIVGLEREVEASKK---QAELDRKAMDELLRERDILNKNMLKA-----V 397
             +E+ K  L+ ++  L  +++  ++     E  ++  D+LL E   ++            
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
             A +K+T  + L    +  LE      K+E ++  K+   L+ E +  ++   D+ + V 
Sbjct: 1484 EAREKETKALSLARALEEALEA-----KEELERTNKM---LKAEMEDLVSSKDDVGKNVH 1535

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQN----LYEAVRSDRNLYSKNLVEAQDEIT 513
               +  +  ETQ+ + + ++ E E +L+  ++    L   +++ +  + ++L    ++  
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 514  DMKRKLKIMIHQVDELKED--------ISAK---ESALVKLHLEQQRIEKEKETLKAELQ 562
            + +R+L+  +H+ +   ED         +AK   E  L  L L+     K +E    +L+
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 563  KLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRND 622
            KL+ Q  + +  +E   A   ++     E   E+  +  E D +  + D+  ++  R+  
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKE--NEKKAKSLEADLMQLQEDLAAAERARKQA 1713

Query: 623  ELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            +L       ++  S+  +   Q  +R  + RI +LE ++L  E+G +      V +  Q+
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE-EELEEEQGNMEAMSDRVRKATQQ 1772

Query: 683  FFHMQRELLKERTRCRALE---EELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLIS 739
               +  EL  ER+  +  E   ++LE      R +  E       +    I  L+ ++  
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832

Query: 740  KTEEVVE-------------------KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY 780
              E+V +                   KE+LLQ +++  M  ++    + G    +QLK  
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK-- 1890

Query: 781  RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
             R L + +++ + +++     + +  E     E +  E+  LK K      +E  Q
Sbjct: 1891 -RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945



 Score =  114 bits (285), Expect = 4e-25
 Identities = 159/871 (18%), Positives = 363/871 (41%), Gaps = 83/871 (9%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            +Q   E+  +E+E+       +L+ +K+L + +++ E    +  ++ +   RL AK +EL
Sbjct: 874  RQQKAENELKELEQKHS----QLTEEKNLLQEQLQAET--ELYAEAEEMRVRLAAKKQEL 927

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
               +    A+    L+  +D    + + +K++ +    ++   ++E+ A++ +   K   
Sbjct: 928  EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
                K +E    L MD  +N         +++KER  L   +  L  +LA+  E+ +   
Sbjct: 984  EAKIKKLEDEI-LVMDDQNN---------KLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 188  RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
            + K + E  IS+ +  +++ +       + K KLE +       +   Q +I  L+  + 
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 248  KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            K +EELQ    +L ++      A K++ + +   + LQ++ +       +  ++ +    
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153

Query: 308  ELKAKEEEVHQMRLDIGKLNKIREQIHKKL--------HHTEDQKAEVEQHKETLKNQIV 359
            EL+A + E+           ++R +  +++          T   +A+V++ ++     + 
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213

Query: 360  GLEREVEASKK-QAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLE 418
             L  ++E  K+ +A LD+          D+  +  L+ +   +++       E  K+ LE
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE--LRVLGQAKQEV------EHKKKKLE 1265

Query: 419  GEIQNYKDEAQKQRKI-------IFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIF 471
             ++Q  + +     +        +  L+ E +      ++   K +   +D+    +Q+ 
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325

Query: 472  DYRKKIAES-------EIKLKQ--------QQNLYEAVRSDRNLYSKNLVEAQDEITDMK 516
            D ++ + E          KL+Q        Q  L E + + +NL  +++     +++D K
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK 1384

Query: 517  RKLKIMIHQVDELKEDISAKESALVKLHLEQQ-------RIEKEKETLKAELQKLRQQAL 569
            +KL+     V+ L+E     +  +  L  + +       ++EK K  L+ EL  L     
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444

Query: 570  ETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV---ISERDILGSQLVRRNDELAL 626
              +  +   E ++RK  +++AE      +   E D+      E++     L R  +E   
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504

Query: 627  LYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSM-ANVEELRQEFFH 685
              E+++    +L           +D+     E++K +R        M   +EEL  E   
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1564

Query: 686  MQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVV 745
             +   L+     +AL+ + E  L      + E ++    +L +++H  +  L    +E  
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQLQRQLHEYETEL---EDERK 1617

Query: 746  EKELLLQEKEKLYMELKHV-----LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNM 800
            ++ L    K+KL  +LK +      A +   EA +QL+  +  + D +++L+   +  + 
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1677

Query: 801  YEVQSKEYKYEVEKLTNELQNLKKKYLAQKR 831
                +KE + + + L  +L  L++   A +R
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAER 1708



 Score =  114 bits (284), Expect = 5e-25
 Identities = 145/669 (21%), Positives = 296/669 (44%), Gaps = 100/669 (14%)

Query: 197  ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
            +++ ++E+Q +++E  +   +++K E ELK+              L+Q   +  EE   L
Sbjct: 854  VTRQEEEMQAKEDELQKTKERQQKAENELKE--------------LEQKHSQLTEEKNLL 899

Query: 257  EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++QL+ +  L      E E+ ++R A  +QE E+     E   +E + +  +L+A+ +++
Sbjct: 900  QEQLQAETEL----YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955

Query: 317  HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREV---EASKKQAE 373
             Q  LD          + ++L   E  + +++  K T + +I  LE E+   +    +  
Sbjct: 956  AQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 374  LDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
             +RK ++E + +   L  N+ +     +  T L   HE     LE  ++  K+E  +Q  
Sbjct: 1006 KERKLLEERISD---LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--KEEKSRQ-- 1058

Query: 434  IIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL-KQQQNLYE 492
                LEK + +    ASD  +              QI D + +IAE +++L K+++ L  
Sbjct: 1059 ---ELEKLKRKLEGDASDFHE--------------QIADLQAQIAELKMQLAKKEEELQA 1101

Query: 493  AV-RSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIE 551
            A+ R D  +  KN         +  +K++ +   + +L+ED+ ++ +A  K   +++ + 
Sbjct: 1102 ALARLDDEIAQKN---------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152

Query: 552  KEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERD 611
            +E E LK EL+         +    K+E E   L + + E       Q +E+ Q      
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------ 1206

Query: 612  ILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED----MRILRLEIKKLRREKG 667
                +  +  +EL    E+ K  ++ L+K +    +   D    +R+L    +++  +K 
Sbjct: 1207 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262

Query: 668  ILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
             L    A V+EL+ +    +R   +   +   L+ E+E+   +     L  ++  A +L 
Sbjct: 1263 KLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-----LNEAEGKAIKLA 1314

Query: 728  QKIHTLQKRLISKTEEVVEKE----LLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRR- 782
            + + +L  +L   T+E++++E    L +  K +   E ++ L  Q   E   +  L R  
Sbjct: 1315 KDVASLSSQL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373

Query: 783  -----TLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQ 836
                  L D K++L+  +S +   E   K ++ E+E LT + +     Y   +K K +LQ
Sbjct: 1374 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433

Query: 837  KNKDTAPMD 845
            +  D   +D
Sbjct: 1434 QELDDLVVD 1442


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  130 bits (326), Expect = 7e-30
 Identities = 196/1004 (19%), Positives = 402/1004 (40%), Gaps = 205/1004 (20%)

Query: 3    EEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKS------YDN 56
            E++G +   E     +   D +  L E   + + +K ++E     A +KK        D+
Sbjct: 935  EDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992

Query: 57   EKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA 116
            +   ++K R+L  E +   + + T L   ++    +  LK + E     ++    KE+K+
Sbjct: 993  QNNKLSKERKLLEERI---SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 117  KETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL----LRFKEEVTKERDQLLSEVVKL 172
            ++ +  LK ++           G + D H  I DL       K ++ K+ ++L + + +L
Sbjct: 1050 RQELEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 173  RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
             + +AQ     ++      E E  IS  Q+++   +   ++  ++K  L +EL+ ++ ++
Sbjct: 1100 DDEIAQKNNALKKIR----ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 233  DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE---------------LEQF 277
            +         Q+   K ++E+  L++ L E+   +E   +E               LEQF
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215

Query: 278  QMRNAKLQQ-----ENEQHSLVCE-----QLSQENQQKALELKAKEEE------------ 315
            +   A L +     E E   L  E     Q  QE + K  +L+A+ +E            
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275

Query: 316  ------VHQMRLDI-----------GKLNKIREQI---HKKLHHTEDQKAEVEQHKETLK 355
                  VH+++ ++           GK  K+ + +     +L  T++   E  + K  + 
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335

Query: 356  NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKR 415
             ++  LE E  + + Q + + +A   L R    LN  +  +    Q     V+  E+ K+
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 416  NLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT------QKVLMNMEDIKVRETQ 469
              + EI+N   + +++      LEK ++R   +  DL       ++++ N+E  + +  Q
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 470  IFDYRKKI----------AESEIKLKQQQNLY------EAVRSDRNLYSKN--------- 504
            +    K I          AE+E + K+ + L       EA+ +   L   N         
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 505  LVEAQD-------EITDMKRKLKIMIH----QVDELKEDISAKESALVKLHLEQQRI--- 550
            LV ++D       E+   KR L+  +     Q++EL++++ A E A ++L +  Q +   
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 551  -EKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
             E++ +    + ++ R+Q     H  E +  +ERK   + A A       KK+L+  + +
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA-------KKKLEGDLKD 1628

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGIL 669
             ++     ++  +E      K++ Q          + + LED R  R EI    +E    
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMK-------DFQRELEDARASRDEIFATAKENEKK 1681

Query: 670  ARSM-ANVEELRQEFFHMQR----------ELLKE------------------RTRCRAL 700
            A+S+ A++ +L+++    +R          EL +E                    R   L
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQL 1741

Query: 701  EEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYME 760
            EEELE          +EA      +  Q+   L   L ++     + E   Q+ E+   E
Sbjct: 1742 EEELEEEQG-----NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 761  LKHVLARQPGP------------------------EAAEQLKLYRRTLHDKKQQLKVLSS 796
            L+  L    G                         + A + +   ++L  K ++LK +  
Sbjct: 1797 LRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856

Query: 797  ELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQKNK 839
            ++      +++YK + EK    ++ LK++   A++  +++  N+
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900



 Score =  123 bits (309), Expect = 6e-28
 Identities = 162/780 (20%), Positives = 333/780 (42%), Gaps = 100/780 (12%)

Query: 33   DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTI 92
            DK+ +    E   L   ++     ++ +  K ++L A++    +K +   +   +    +
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKV 1282

Query: 93   ASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLL 152
              L+ E+E    M++ A  K  K  + + +L  ++ +  +L+++ +   ++  + +R L 
Sbjct: 1283 HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL- 1341

Query: 153  RFKEEVTKERDQLLSE----------VVKLRESLAQTTEQQQETERSKEEAEHAISQFQQ 202
              +EE    +DQL  E          +  L   L+ + ++ Q+   + E  E    +FQ+
Sbjct: 1342 --EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 203  EIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
            EI+    +   +    +KLEK   ++Q ++D    ++   +Q V   +++ +K +Q L E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 263  QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQM-RL 321
            +K ++ + A E ++ +       +E E  +L   +  +E    ALE K + E  ++M + 
Sbjct: 1460 EKNISSKYADERDRAEAE----AREKETKALSLARALEE----ALEAKEELERTNKMLKA 1511

Query: 322  DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEAS------------- 368
            ++  L   ++ + K +H  E  K  +E   E +K Q+  LE E++A+             
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 369  -KKQAELDRKAMDELLRE-RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKD 426
             K Q E D +A DE   E R  L + + +     + +     L   AK+ LEG++++ + 
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 427  EAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQ 486
            +A    K      K+  +   Q  D  ++    +ED +    +IF   K   E+E K K 
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRE----LEDARASRDEIFATAK---ENEKKAKS 1684

Query: 487  QQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
             +               +L++ Q+++   +R  K    + +EL E++++  S        
Sbjct: 1685 LE--------------ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG------- 1723

Query: 547  QQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
            +  ++ EK  L+A + +L ++  E +  +E      RK  +   +   E   ++    + 
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 607  ISERDILGSQLVRRNDEL-ALLYE-------KIKIQQSVLNKGESQYNQRLE-DMRILRL 657
             S R     QL R+N EL + L+E       K K   + L    +Q  +++E + R  + 
Sbjct: 1784 ESAR----QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 658  EIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLE 717
              K L+++   L   +  VE+ R+     + +  K   R + L+ +LE            
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE------------ 1887

Query: 718  ASDPNAYELIQKIHTLQKRLISKTEEVVE-KELLLQEKEKLYMELKHVLARQPGPEAAEQ 776
                 A E  Q+I+  +++L  + +E  E  E + +E   L  +L     R P P+   Q
Sbjct: 1888 ----EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL-----RGPPPQETSQ 1938



 Score =  119 bits (297), Expect = 2e-26
 Identities = 162/737 (21%), Positives = 329/737 (44%), Gaps = 99/737 (13%)

Query: 157  EVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQE--IQQRQNEASRE 214
            +VT++ +++ ++     + L +T E+QQ+ E   +E E   SQ  +E  + Q Q +A  E
Sbjct: 846  QVTRQEEEMQAK----EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901

Query: 215  F------------RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKE 262
                          KK++LE+ L +++A ++  +   + LQ   +K  +++  LE+QL+E
Sbjct: 902  LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 263  QKILNERAAKELEQFQMRNAKLQQE-----------NEQHSLVCEQLSQ------ENQQK 305
            ++   ++   E    + +  KL+ E           +++  L+ E++S       E ++K
Sbjct: 962  EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021

Query: 306  A---LELKAKEEE-VHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGL 361
            A    +LK K E  + ++ + + K  K R+++ K     E   ++  +    L+ QI   
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-- 1079

Query: 362  EREVEASKKQAELD---RKAMDELLRERDILNKNMLKAVNATQKQTDLVKLH------EQ 412
            E +++ +KK+ EL     +  DE+ ++ + L K      + +  Q DL          E+
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 413  AKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFD 472
             KR+L  E++  K E +         ++ R +   + + L + +    E+ +  E Q+ +
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL---DEETRSHEAQVQE 1196

Query: 473  YRKKIAESEIKLKQQQNLYEAVRS--DRN---LYSKN---------LVEAQDEITDMKRK 518
             R+K A++  +L +Q   ++  ++  D+N   L  +N         L +A+ E+   K+K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 519  LKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ 578
            L+    QV EL+   S  E A  +L+ +  +++ E E++   L +   +A++    +   
Sbjct: 1257 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 579  EAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVL 638
             ++ +    ++ E   ++L    +L Q+  ER+ L  QL    DE     + ++   S L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL----DEEMEAKQNLERHISTL 1369

Query: 639  NKGESQYNQRLEDM--RILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLK-ERT 695
            N   S   ++L+D    +  LE  K R +K         +E L Q++        K E+T
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQK--------EIENLTQQYEEKAAAYDKLEKT 1421

Query: 696  RCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISK-TEEVVEKELLLQEK 754
            + R  +E  +  +++   R+L ++         ++   +K + SK  +E    E   +EK
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 755  EKLYMELKHVLARQPGPEAAEQLKLYRRTL-----------HDKKQQLKVLSSELNMYEV 803
            E   + L   L  +   EA E+L+   + L            D  + +  L       E 
Sbjct: 1482 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539

Query: 804  QSKEYKYEVEKLTNELQ 820
            Q +E K ++E+L +ELQ
Sbjct: 1540 QMEEMKTQLEELEDELQ 1556



 Score =  117 bits (294), Expect = 4e-26
 Identities = 169/896 (18%), Positives = 374/896 (41%), Gaps = 91/896 (10%)

Query: 12   EESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRELNAEI 71
            + S F E   D Q  + EL     L K   E +   A +      +   + K REL   I
Sbjct: 1063 DASDFHEQIADLQAQIAELK--MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120

Query: 72   V-----VNSAKVAT--ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALK 124
                  ++S + A   A K  +D    + +LK E+E       +  +   K ++ +  LK
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180

Query: 125  EEIVNLTKLVEQGSGLSMDQHSN-IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQ 183
            + +   T+  E        +H+  + +L    E+  + +  L      L +  A    + 
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 184  QETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQ 243
            +   ++K+E EH   + + ++Q+ Q++ S   R + +L  ++ ++Q +++S    +   +
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 244  QYVQKSKEELQKLEQQLKE-QKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQEN 302
                K  +++  L  QL++ Q++L E   ++L      + KL+Q  E+ + + +QL +E 
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV----STKLRQLEEERNSLQDQLDEEM 1356

Query: 303  QQKA----------LELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAE------ 346
            + K           ++L   ++++      +  L + +++  K++ +   Q  E      
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416

Query: 347  -VEQHKETLKNQIVGLEREVEASKK---QAELDRKAMDELLRERDILNKNMLKA-----V 397
             +E+ K  L+ ++  L  +++  ++     E  ++  D+LL E   ++            
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 398  NATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL 457
             A +K+T  + L    +  LE      K+E ++  K+   L+ E +  ++   D+ + V 
Sbjct: 1477 EAREKETKALSLARALEEALEA-----KEELERTNKM---LKAEMEDLVSSKDDVGKNVH 1528

Query: 458  MNMEDIKVRETQIFDYRKKIAESEIKLKQQQN----LYEAVRSDRNLYSKNLVEAQDEIT 513
               +  +  ETQ+ + + ++ E E +L+  ++    L   +++ +  + ++L    ++  
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 514  DMKRKLKIMIHQVDELKED--------ISAK---ESALVKLHLEQQRIEKEKETLKAELQ 562
            + +R+L+  +H+ +   ED         +AK   E  L  L L+     K +E    +L+
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 563  KLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRND 622
            KL+ Q  + +  +E   A   ++     E   E+  +  E D +  + D+  ++  R+  
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKE--NEKKAKSLEADLMQLQEDLAAAERARKQA 1706

Query: 623  ELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQE 682
            +L       ++  S+  +   Q  +R  + RI +LE ++L  E+G +      V +  Q+
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLE-EELEEEQGNMEAMSDRVRKATQQ 1765

Query: 683  FFHMQRELLKERTRCRALE---EELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLIS 739
               +  EL  ER+  +  E   ++LE      R +  E       +    I  L+ ++  
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825

Query: 740  KTEEVVE-------------------KELLLQEKEKLYMELKHVLARQPGPEAAEQLKLY 780
              E+V +                   KE+LLQ +++  M  ++    + G    +QLK  
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK-- 1883

Query: 781  RRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQ 836
             R L + +++ + +++     + +  E     E +  E+  LK K      +E  Q
Sbjct: 1884 -RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938



 Score =  114 bits (285), Expect = 4e-25
 Identities = 159/871 (18%), Positives = 363/871 (41%), Gaps = 83/871 (9%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            +Q   E+  +E+E+       +L+ +K+L + +++ E    +  ++ +   RL AK +EL
Sbjct: 867  RQQKAENELKELEQKHS----QLTEEKNLLQEQLQAET--ELYAEAEEMRVRLAAKKQEL 920

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
               +    A+    L+  +D    + + +K++ +    ++   ++E+ A++ +   K   
Sbjct: 921  EEILHEMEAR----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETE 187
                K +E    L MD  +N         +++KER  L   +  L  +LA+  E+ +   
Sbjct: 977  EAKIKKLEDEI-LVMDDQNN---------KLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 188  RSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
            + K + E  IS+ +  +++ +       + K KLE +       +   Q +I  L+  + 
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 248  KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKAL 307
            K +EELQ    +L ++      A K++ + +   + LQ++ +       +  ++ +    
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146

Query: 308  ELKAKEEEVHQMRLDIGKLNKIREQIHKKL--------HHTEDQKAEVEQHKETLKNQIV 359
            EL+A + E+           ++R +  +++          T   +A+V++ ++     + 
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206

Query: 360  GLEREVEASKK-QAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLE 418
             L  ++E  K+ +A LD+          D+  +  L+ +   +++       E  K+ LE
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE--LRVLGQAKQEV------EHKKKKLE 1258

Query: 419  GEIQNYKDEAQKQRKI-------IFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIF 471
             ++Q  + +     +        +  L+ E +      ++   K +   +D+    +Q+ 
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318

Query: 472  DYRKKIAES-------EIKLKQ--------QQNLYEAVRSDRNLYSKNLVEAQDEITDMK 516
            D ++ + E          KL+Q        Q  L E + + +NL  +++     +++D K
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK 1377

Query: 517  RKLKIMIHQVDELKEDISAKESALVKLHLEQQ-------RIEKEKETLKAELQKLRQQAL 569
            +KL+     V+ L+E     +  +  L  + +       ++EK K  L+ EL  L     
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437

Query: 570  ETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV---ISERDILGSQLVRRNDELAL 626
              +  +   E ++RK  +++AE      +   E D+      E++     L R  +E   
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497

Query: 627  LYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSM-ANVEELRQEFFH 685
              E+++    +L           +D+     E++K +R        M   +EEL  E   
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA 1557

Query: 686  MQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVV 745
             +   L+     +AL+ + E  L      + E ++    +L +++H  +  L    +E  
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQA----RDEQNEEKRRQLQRQLHEYETEL---EDERK 1610

Query: 746  EKELLLQEKEKLYMELKHV-----LARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNM 800
            ++ L    K+KL  +LK +      A +   EA +QL+  +  + D +++L+   +  + 
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1670

Query: 801  YEVQSKEYKYEVEKLTNELQNLKKKYLAQKR 831
                +KE + + + L  +L  L++   A +R
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAER 1701



 Score =  114 bits (284), Expect = 5e-25
 Identities = 145/669 (21%), Positives = 296/669 (44%), Gaps = 100/669 (14%)

Query: 197  ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKL 256
            +++ ++E+Q +++E  +   +++K E ELK+              L+Q   +  EE   L
Sbjct: 847  VTRQEEEMQAKEDELQKTKERQQKAENELKE--------------LEQKHSQLTEEKNLL 892

Query: 257  EQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEV 316
            ++QL+ +  L      E E+ ++R A  +QE E+     E   +E + +  +L+A+ +++
Sbjct: 893  QEQLQAETEL----YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948

Query: 317  HQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREV---EASKKQAE 373
             Q  LD          + ++L   E  + +++  K T + +I  LE E+   +    +  
Sbjct: 949  AQQMLD----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 374  LDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRK 433
             +RK ++E + +   L  N+ +     +  T L   HE     LE  ++  K+E  +Q  
Sbjct: 999  KERKLLEERISD---LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK--KEEKSRQ-- 1051

Query: 434  IIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL-KQQQNLYE 492
                LEK + +    ASD  +              QI D + +IAE +++L K+++ L  
Sbjct: 1052 ---ELEKLKRKLEGDASDFHE--------------QIADLQAQIAELKMQLAKKEEELQA 1094

Query: 493  AV-RSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIE 551
            A+ R D  +  KN         +  +K++ +   + +L+ED+ ++ +A  K   +++ + 
Sbjct: 1095 ALARLDDEIAQKN---------NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145

Query: 552  KEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERD 611
            +E E LK EL+         +    K+E E   L + + E       Q +E+ Q      
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ------ 1199

Query: 612  ILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED----MRILRLEIKKLRREKG 667
                +  +  +EL    E+ K  ++ L+K +    +   D    +R+L    +++  +K 
Sbjct: 1200 ----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255

Query: 668  ILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELI 727
             L    A V+EL+ +    +R   +   +   L+ E+E+   +     L  ++  A +L 
Sbjct: 1256 KLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-----LNEAEGKAIKLA 1307

Query: 728  QKIHTLQKRLISKTEEVVEKE----LLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRR- 782
            + + +L  +L   T+E++++E    L +  K +   E ++ L  Q   E   +  L R  
Sbjct: 1308 KDVASLSSQL-QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366

Query: 783  -----TLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY-LAQKRKEQLQ 836
                  L D K++L+  +S +   E   K ++ E+E LT + +     Y   +K K +LQ
Sbjct: 1367 STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426

Query: 837  KNKDTAPMD 845
            +  D   +D
Sbjct: 1427 QELDDLVVD 1435


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score =  129 bits (323), Expect = 2e-29
 Identities = 210/949 (22%), Positives = 414/949 (43%), Gaps = 178/949 (18%)

Query: 3    EEKGGKQVLEESA-FEEMERDFQGVLHELSGDKSLEKFRI---EYERLHAVMKKSY---- 54
            EE+   + +EE A  EE     +G L  +    S + ++    E++++H   +KS+    
Sbjct: 1423 EERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWK 1482

Query: 55   -DNEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLK-KEIEKAWKMVDSAYDK 112
             + EKRL+ +  +L+        K++   ++ Q+D+     LK +E ++ W+ + S+  K
Sbjct: 1483 EEWEKRLLQEEEKLHQA----GEKLSPEEEMLQEDK----KLKWEEWKQVWENMLSSKSK 1534

Query: 113  EQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEV--V 170
            EQ+ K+      EE V L + V              R+    +++VT+E+  +  E    
Sbjct: 1535 EQQYKD------EEEVTLEEEVS-------------REGEEKEQQVTEEQRHIQEEHKWA 1575

Query: 171  KLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQA 230
            ++    A+  +++ + ER   + E  ++Q ++++ Q + + ++ + K  + ++E+ Q + 
Sbjct: 1576 RIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEG 1635

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
                ++   + L Q  +K  +E +KL Q+ K+     E+ A+E E+   +  KL +    
Sbjct: 1636 KFAQKE---ETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNI 1692

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQH 350
             +   E+L Q  Q    + K   +E+ ++  D+ +L+   E+++++     ++K ++ + 
Sbjct: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752

Query: 351  KETLKNQIVGLERE-----------VEASKKQAELDRKAMDE---LLRERDILNKNMLKA 396
            +E L  Q   L  E           ++  +K A+   K  +E   L R+R+ L +  +K 
Sbjct: 1753 EEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812

Query: 397  VNATQKQTDLV------KLHEQAKRNLEGEIQNYKDEAQK--QRKIIFHLEKERDRY--- 445
                ++  + +      K+    K+NL  E +N   E +K  QRK      KER  +   
Sbjct: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872

Query: 446  ----INQASDLTQKVLMNMEDIKVRETQ-IFDYRKKIAESEIKLKQQQNLYEAVRSDRNL 500
                +     +  K+L  +E+   +E + +   ++K+AE+E KL Q ++           
Sbjct: 1873 QLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVED----------- 1921

Query: 501  YSKNLVEAQDEITDMKRKL---KIMIHQVDELKE--DISAKESAL----VKLHLEQQRIE 551
               +L + Q+++   K KL   K M+     L+   DI+ +E AL     +L  E+ R+ 
Sbjct: 1922 ---SLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLV 1978

Query: 552  KEKETL-KAELQKLRQQ----ALETKHFIEKQEAEERKLL---RIIAEADGERLRQKKEL 603
            + KETL K E  +  +Q     +E + F  K   EE+ LL   RI+A  + E  + K E 
Sbjct: 1979 EGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEF 2038

Query: 604  D------------------QVISERDILGSQLVRRN-----------DELALLYEKIK-- 632
                               ++I +R+ L  +  + N           DE  L  E+IK  
Sbjct: 2039 TRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMT 2098

Query: 633  --------------IQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILA---RSMAN 675
                          I+QS L+  E  ++++  +   L  + KKL R++  LA   R M N
Sbjct: 2099 KMKRALFVKERRLSIEQSKLDIKEWDFSEKRSE---LTKDEKKLARKQRKLANKMRRMIN 2155

Query: 676  VEELRQE----FFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIH 731
             EE   E          E++ +      +EEE   P    RWRK + +        ++  
Sbjct: 2156 KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA--------KRGD 2207

Query: 732  TLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQL 791
              +++  S+ +EV  +E   +E E L  EL+            +Q  L      +++++ 
Sbjct: 2208 KPKEKFSSQVDEVESEEHFSEEMESLLDELE------------KQESLSSEEEEEREEEE 2255

Query: 792  KVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKD 840
            +    E+   E + KE +   EK   + +  KKK   +K+KE++Q+ ++
Sbjct: 2256 EREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEE 2304



 Score =  103 bits (257), Expect = 7e-22
 Identities = 180/806 (22%), Positives = 356/806 (44%), Gaps = 92/806 (11%)

Query: 11   LEESAFEEMERDFQGVLHELSGDKSLEKF-RIEYERLHAVMKKSYDNEKRLMA--KCREL 67
            LEE    E E   Q V  E    +   K+ RI  +R  A  K++ +  K      K  + 
Sbjct: 1546 LEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQE 1605

Query: 68   NAEIVVNSAKVATA-LKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA-----KETIL 121
              ++     K+A A +K++QDD+    +  K  +K   +        Q+A     K   L
Sbjct: 1606 ERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKL 1665

Query: 122  ALKEEIV--NLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLS-EVVKLRESLAQ 178
            A K E V     KL ++G  L+      ++++L  K E   +R+Q L  +  +L + L +
Sbjct: 1666 AKKWEKVAREEEKLAKKGGKLA-----EVKNILAQKVEELPQREQNLDWQEKELAQELEE 1720

Query: 179  TTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTE 238
                 +E    +EE      +  +E ++   E      ++EKL +E  ++  + +    E
Sbjct: 1721 LEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQE 1780

Query: 239  IKALQQYVQKSKEELQKL---EQQLKEQKIL----NERAAKELEQ--------FQMRNAK 283
             + L Q+ +K  EE ++L    +QL E+K+      ER    +E+        +Q +N  
Sbjct: 1781 KEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKN-- 1838

Query: 284  LQQENEQHSLVCEQLSQENQQKALE---LKAKEEEVHQMRLDIGKLNKIREQIHKKLHHT 340
            L QE +  +   E+L+Q  +        L   ++++ Q++  +G  NKI  Q+ +KL  T
Sbjct: 1839 LAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKL--T 1896

Query: 341  EDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNAT 400
            ++++  +++ ++  + +   ++ E   +KKQ +L ++ M   L +  +  K  L+     
Sbjct: 1897 QEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDI 1956

Query: 401  QKQT-----DLVKLHEQAKRNLEGEIQNYKDEA---QKQRKIIFHLEKERDRYINQASDL 452
             K+      ++ +L E+  R +EG+    K E     +QRK+    + E++ +  + S L
Sbjct: 1957 AKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMT---QVEQELFERKLS-L 2012

Query: 453  TQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLY--SKNLVEAQD 510
             +K+L++ + I   E        +IA+ +++  + Q ++  V+  R L   S+ L++ ++
Sbjct: 2013 EEKILLHEDRILAME------ESEIAKGKLEFTRGQRIF--VQGQRKLAKASRKLIKKRE 2064

Query: 511  EITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKL--RQQA 568
             ++    KL  ++  + +L  D         KL  E+ ++ K K  L  + ++L   Q  
Sbjct: 2065 SLSKEPAKLNKILKALQKLTRDER-------KLTQEEIKMTKMKRALFVKERRLSIEQSK 2117

Query: 569  LETKH--FIEKQEA---EERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDE 623
            L+ K   F EK+     +E+KL R   +   +  R   + +++  E     S+L R++ E
Sbjct: 2118 LDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEE----SKLARKHSE 2173

Query: 624  LALLYEKIK--IQQSVLNKGESQYNQRLEDMR------ILRLEIKKLRREKGILARSMAN 675
            + L  E+     ++ V+   + ++ +R E  R          ++ ++  E+       + 
Sbjct: 2174 VILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESL 2233

Query: 676  VEEL-RQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQ 734
            ++EL +QE    + E  +E    R  EE  E        RK E          ++    +
Sbjct: 2234 LDELEKQESLSSEEEEEREEEEEREEEEVREE----EEERKEEEEGEEKQVEKEEEEKKK 2289

Query: 735  KRLISKTEEVVEKELLLQEKEKLYME 760
            K+   K EEV EKE + +EKE++  E
Sbjct: 2290 KKKEKKKEEVQEKEEVFEEKEEIMSE 2315



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 153/668 (22%), Positives = 286/668 (42%), Gaps = 94/668 (14%)

Query: 216  RKKEKLEKELKQIQADM-DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKEL 274
            +  E L  EL     +M   R    +  Q+     K+E + L + L    +  E+    +
Sbjct: 1260 KMSENLNAELVTFAQEMLVDRHPSWELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFI 1319

Query: 275  EQFQMRNAKLQ---QENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGK----LN 327
            ++  +R   +Q   QE  +H  V  +  ++ Q+KA ++   EE   Q+ L  GK    L 
Sbjct: 1320 QEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLGLEET--QVILKKGKKVIFLE 1377

Query: 328  KIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERD 387
                 + K++   E++K   +  K+  K   V  ER+V   K++   + + M E + E  
Sbjct: 1378 PGNVTMGKEISKKEEKKTFQKSPKQGRK--AVQKERKVGKIKREMTKEERDMSEEVEEMA 1435

Query: 388  ILNKNMLKA------VNATQKQTDLVKLHEQAKRNLEGEIQN----YKDEAQKQRKIIFH 437
             L + ++K       +  T    D  K  ++ K+ + GE +     +K+E +K+      
Sbjct: 1436 TLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQ-VHGETRKSWKAWKEEWEKR------ 1488

Query: 438  LEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLY---EAV 494
            L +E ++       L+ +  M  ED K++    ++  K++ E+ +  K ++  Y   E V
Sbjct: 1489 LLQEEEKLHQAGEKLSPEEEMLQEDKKLK----WEEWKQVWENMLSSKSKEQQYKDEEEV 1544

Query: 495  RSDRNLYSKNLVEAQDEITDMKRKLK-----IMIHQVDELKEDISAKESALVKLHLEQQR 549
              +  + S+   E + ++T+ +R ++       IH+     E   A+E    KL  E+++
Sbjct: 1545 TLEEEV-SREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEER--KLAQEEEK 1601

Query: 550  IEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISE 609
            + +E+  L  E +KL Q  ++    I + + E       +A+A+G+  ++++ L Q   +
Sbjct: 1602 LAQEERQLAQEERKLAQAYVK----ITQDDRE-------MAQAEGKFAQKEETLAQRGEK 1650

Query: 610  RDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGIL 669
                  +L ++  +LA  +EK+  ++  L K                    KL   K IL
Sbjct: 1651 LSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGG-----------------KLAEVKNIL 1693

Query: 670  ARSMANVEELRQEFFHMQRELLKERTRCRALEEEL---ENPLNVHRWRKLEASDPNAYEL 726
            A+ +  + +  Q     ++EL +E        EEL   E  LN    + +E     A E 
Sbjct: 1694 AQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEE 1753

Query: 727  IQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHD 786
                   +K    +T+   E+ELL+QEKEKL         ++  PE  E+L   R  L +
Sbjct: 1754 EALAWQREKLSEEETKLAQEEELLIQEKEKLAQH------KEKMPEEEERLGRKREQLIE 1807

Query: 787  KKQQLKVLSSELNMYEVQSKE-YKYEVEKLT-NELQNLKKKYLAQKRKEQLQKNKDTAPM 844
            KK +L            Q +E +   +E+LT N++   +KK LAQ++K   Q+ +  A  
Sbjct: 1808 KKMKL-----------AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQR 1856

Query: 845  DNTFLMVK 852
                L  K
Sbjct: 1857 KENLLYNK 1864



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 174/830 (20%), Positives = 336/830 (40%), Gaps = 164/830 (19%)

Query: 168  EVVKLRESLAQTTEQQQETERSK---EEAEHAISQFQQEI-----------QQRQNEASR 213
            EV++ +E + +  EQ Q+  R     EE +  + + ++ I           +  + E  +
Sbjct: 1335 EVIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKK 1394

Query: 214  EF--------------RKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLE-- 257
             F              RK  K+++E+ + + DM     E+  L++ V K + +L  +E  
Sbjct: 1395 TFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERT 1454

Query: 258  -------QQLKEQKILNERAAKELEQFQMR-NAKLQQENEQHSLVCEQLSQENQQKALEL 309
                   +   E K ++    K  + ++     +L QE E+     E+LS E +    + 
Sbjct: 1455 PSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDK 1514

Query: 310  KAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVE--- 366
            K K EE  Q+  ++   +K +EQ +K       ++ EV +  E  + Q+   +R ++   
Sbjct: 1515 KLKWEEWKQVWENM-LSSKSKEQQYKDEEEVTLEE-EVSREGEEKEQQVTEEQRHIQEEH 1572

Query: 367  -----------ASKKQAELDRKAMDE---LLRERDILNKNMLKAVNA------------- 399
                       A KK+A+ +RK   E   L +E   L +   K   A             
Sbjct: 1573 KWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQ 1632

Query: 400  -----TQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEK-------------- 440
                  QK+  L +  E+  +  E   Q  K  A+K  K+    EK              
Sbjct: 1633 AEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNI 1692

Query: 441  ---------ERDRYIN-QASDLTQ---KVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQ 487
                     +R++ ++ Q  +L Q   ++  +ME++  +E ++     K+ E + KL ++
Sbjct: 1693 LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEE 1752

Query: 488  QNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALV--KLHL 545
            +      R   +     L + ++ +   K KL     ++ E +E +  K   L+  K+ L
Sbjct: 1753 EEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL 1812

Query: 546  EQQR----------------------IEKEKETLKAELQKLRQQALETKHFIEKQEAEER 583
             Q+R                      + +EK+ L  E +KL Q+     +  E+    ++
Sbjct: 1813 AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKK 1872

Query: 584  KLL----------RIIAEADGERLRQKKELDQVISERDILG---SQLVRRNDELALLYEK 630
            +L+          +I+A+ + E+L Q+KE   VI +++ L     +LV+  D LA   EK
Sbjct: 1873 QLVQVKNKLGMFNKILAQVE-EKLTQEKE--TVIKKKEKLAETEKKLVQVEDSLAKKQEK 1929

Query: 631  IKIQQS--VLNKGESQYNQRL-------EDMRILRLEIKKLRREKGILARSMANVEELRQ 681
            +  ++    L K   Q  +RL       ++ + L LE+K+L  EK  L      + +   
Sbjct: 1930 LAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGET 1989

Query: 682  EFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPN------AYELIQKIHTLQK 735
                 QR++ +        +  LE  + +H  R L   +         +   Q+I    +
Sbjct: 1990 PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ 2049

Query: 736  RLISKTEE--VVEKELLLQEKEKLYMELKHV--LARQPGPEAAEQLKL--YRRTLHDKKQ 789
            R ++K     + ++E L +E  KL   LK +  L R       E++K+   +R L  K++
Sbjct: 2050 RKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKER 2109

Query: 790  QLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
            +L +  S+L++ E    E + E+ K   +L   K++ LA K +  + K +
Sbjct: 2110 RLSIEQSKLDIKEWDFSEKRSELTKDEKKLAR-KQRKLANKMRRMINKEE 2158



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 142/677 (20%), Positives = 302/677 (44%), Gaps = 107/677 (15%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCREL 67
            K++ +E   EE+E D +    ELS  +  E+   E  +L    KK  + E+ L  +  +L
Sbjct: 1712 KELAQE--LEELEWDME----ELSWKE--EELNQEEGKLVEEKKKLAEEEEALAWQREKL 1763

Query: 68   NAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEI 127
            + E            KL+Q+++  I   +K  +   KM +      +K ++ I    E+ 
Sbjct: 1764 SEE----------ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLI----EKK 1809

Query: 128  VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKL---RESLAQTTEQQQ 184
            + L +  E+    SM++ +  + +L  K+ + +E+  L  E  KL   +E+L    E+  
Sbjct: 1810 MKLAQKRERWIN-SMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLT 1868

Query: 185  ETERSKEEAEHAISQFQQEIQQRQNEASRE----FRKKEKL---EKELKQIQADMDSRQT 237
             +++   + ++ +  F + + Q + + ++E     +KKEKL   EK+L Q++  +  +Q 
Sbjct: 1869 HSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928

Query: 238  EIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQ 297
            ++   +  +   K  +Q  ++   E  I  E  A  LE  ++   K++    + +L   +
Sbjct: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGE 1988

Query: 298  LSQENQQKALELKAKEEEVHQMRLDIGKLNKIRE---------QIHK-KLHHTEDQKAEV 347
              + ++Q+  ++   E+E+ + +L + +   + E         +I K KL  T  Q+  V
Sbjct: 1989 TPETSRQR--KMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFV 2046

Query: 348  EQHKETLKNQIVGLEREVEASKKQAELDR--KAMDELLRERDILNKNMLKAVNATQKQTD 405
            +  ++  K     +++    SK+ A+L++  KA+ +L R+   L +  +K      K+  
Sbjct: 2047 QGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTK--MKRAL 2104

Query: 406  LVKLH----EQAKRNL------EGEIQNYKDE---AQKQRKIIFHLEK---ERDRYINQA 449
             VK      EQ+K ++      E   +  KDE   A+KQRK+   + +   + ++   + 
Sbjct: 2105 FVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEE 2164

Query: 450  SDLTQK----VLMNMEDIKVRETQIFDYRKK------------------------IAESE 481
            S L +K    +L + E+  + E ++  + K+                        +   E
Sbjct: 2165 SKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEE 2224

Query: 482  IKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALV 541
               ++ ++L + +    +L S+   E ++E    +R+ + +  + +E KE+   +E  + 
Sbjct: 2225 HFSEEMESLLDELEKQESLSSEEEEEREEE---EEREEEEVREEEEERKEEEEGEEKQVE 2281

Query: 542  KLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ--------EAEERKLLRIIAEAD 593
            K   E+++ +K+KE  K E+Q+ +++  E K  I  +        E EE +   +  E D
Sbjct: 2282 KE--EEEKKKKKKEKKKEEVQE-KEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD 2338

Query: 594  GERLRQKKELDQVISER 610
             E+   KKE    + E+
Sbjct: 2339 REKEILKKEKQFKLQEQ 2355



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 78/336 (23%), Positives = 159/336 (47%), Gaps = 58/336 (17%)

Query: 83   KLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETIL-------ALKEEIVNLTKL-- 133
            KL++  +     +++ I K  KM +      +K  E IL         +EE++   K   
Sbjct: 2138 KLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRW 2197

Query: 134  -----VEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETER 188
                  ++G     ++ S+  D +  +E  ++E + LL E+ K +ESL+   E+++E E 
Sbjct: 2198 RKRKEAKRGDK-PKEKFSSQVDEVESEEHFSEEMESLLDELEK-QESLSSEEEEEREEEE 2255

Query: 189  SKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQK 248
             +EE         +E+++ + E      +KE+ E E KQ++ + + ++ + K      +K
Sbjct: 2256 EREE---------EEVREEEEE------RKEEEEGEEKQVEKEEEEKKKKKK------EK 2294

Query: 249  SKEELQKLEQQLKE-QKILNERAAKEL--EQFQMRNAKLQQE--NEQHSLVCEQLSQENQ 303
             KEE+Q+ E+  +E ++I++E   + L  E+ +  +  L++E   E+  L  E+  +  +
Sbjct: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQE 2354

Query: 304  QKALELKAKEEEVHQMR-LDIGKLNKIR----EQIHKKLHHTEDQKAEVEQHKETLKNQI 358
            Q+   L+ +E  +  +R +  GK   IR    +   KKL  T  +  E        K  +
Sbjct: 2355 QRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKE--------KTPV 2406

Query: 359  VGLEREVEASKKQA---ELDRKAMDELLRERDILNK 391
               E+++    K+A   E+ RK +  + +ER+++ K
Sbjct: 2407 PVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGK 2442


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  129 bits (323), Expect = 2e-29
 Identities = 188/828 (22%), Positives = 378/828 (45%), Gaps = 85/828 (10%)

Query: 58   KRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKA-WKMVDSAYDKEQKA 116
            KR M +  E+  E +   A++ + +K        +   K++ E+A ++ ++ A    QK 
Sbjct: 370  KRQMHETLEMKEEEI---AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT 426

Query: 117  KETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVT----KERDQLLSEVVKL 172
            +E    LK E+    K +E+ S    ++ S  ++L R K+EV     K  ++ ++++ KL
Sbjct: 427  EEARRKLKAEMDEQIKTIEKTS--EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL 484

Query: 173  RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLE----KELK-Q 227
             E      EQ+   +    E E    Q +  +++ Q+E  +  ++KE+ E    +EL+ Q
Sbjct: 485  HEKELARKEQELTKKLQTREREFQ-EQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543

Query: 228  IQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKEL-----EQFQMRNA 282
             +A +   + +++ LQQ  +  +  + +LE  L++    N+  +K+L      +    N 
Sbjct: 544  KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603

Query: 283  KLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTED 342
            ++    E+H    E L  ++QQ AL  +  +    Q + ++ KL +  EQ  + L   ++
Sbjct: 604  EITVMVEKHKTELESL--KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661

Query: 343  --QKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNAT 400
               +A +E+  E    ++   + E+E+   +     KA  +L  E  +L     K     
Sbjct: 662  IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL 721

Query: 401  QKQTDLVKLHEQAK-----RNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQK 455
            + + D  K H Q +     +  E  IQ  +   + Q   +  L KERD+++ +     Q 
Sbjct: 722  EAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE----HQA 777

Query: 456  VLMNME-DIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITD 514
             + N+E DIK  E +       + ++  KL   Q+   A       Y + L + Q ++ D
Sbjct: 778  HVENLEADIKRSEGE-------LQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830

Query: 515  MKRKLKIMIHQVDEL---KEDISAK-ESALVKLHLEQQRIEKEKETLKAELQKLRQQALE 570
            ++ +  ++  QV E+   K+D+  + ++  +++    Q++EK+   ++ +++ L  Q  E
Sbjct: 831  LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL-TQVYE 889

Query: 571  TKHFIEKQEAEERKLLRIIAEADGERLR----QKKELDQVISERDILGSQLVRRNDELAL 626
            +K  +E    E+ +  +I+ E +   L+    QKKE+       +IL  +L  + D + +
Sbjct: 890  SK--LEDGNKEQEQTKQILVEKENMILQMREGQKKEI-------EILTQKLSAKEDSIHI 940

Query: 627  LYE----KIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVE-ELRQ 681
            L E    K K Q+  + K + +  +  E ++      KKL  ++  L + + N   EL Q
Sbjct: 941  LNEEYETKFKNQEKKMEKVKQKAKEMQETLK------KKLLDQEAKLKKELENTALELSQ 994

Query: 682  EFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEA-SDPNAYELIQKIHTLQKRLISK 740
            +      ++L+      A   +  + L  ++  ++E+ ++ +  EL   I   +K+L  +
Sbjct: 995  KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ 1054

Query: 741  TEEVVE-KELLLQEKEKLYMELKHVLARQPGPEAAEQLK----------LYRRTLHDKKQ 789
             EE+ E  E+ LQEKE+   ELK  +    G E  E  K              TL++ ++
Sbjct: 1055 AEELQEIHEIQLQEKEQEVAELKQKILLF-GCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 790  QLKVLSSELNMYEVQSKEYKYEVEKLTNEL-QNLKKKYLAQKRKEQLQ 836
            QLK  S+ +N       + K  +EKL  +L ++LK+    Q++  +L+
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161



 Score =  115 bits (289), Expect = 1e-25
 Identities = 188/908 (20%), Positives = 382/908 (42%), Gaps = 114/908 (12%)

Query: 8    KQVLEESAFEEMERDFQGVLHELSG-----DKSLEKFRIEYERLHAVMKKSYDNEKR--- 59
            K+  E  A EE+E   + +L E         +  E +R     L + ++KS    K    
Sbjct: 529  KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 60   -----LMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKM--VDSAYDK 112
                 L A+  + N EI V   K  T L+  +  Q  + + K ++ K      ++   +K
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 113  EQKAKETILALKEEIVN----------LTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKER 162
             ++ KET+L  KE I            L KL  + + L     S + ++L+ + ++ +E 
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE-SLSSELSEVLKARHKLEEEL 707

Query: 163  DQLLSEVVKLRESLA-----QTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRK 217
              L  +  K+++ L      Q    QQ+ +   +E E +I + ++ ++ + N+     ++
Sbjct: 708  SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767

Query: 218  KEK------------------LEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQ 259
            ++K                   E EL+Q  A +D  Q+   A  +  +  +E+L +L+Q+
Sbjct: 768  RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827

Query: 260  LKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQ--ENQQKALELKAKE-EEV 316
            L + +       K++ + + +   +  E + H +  + L Q  E Q   +E K K   +V
Sbjct: 828  LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887

Query: 317  HQMRLDIGKLNKIREQ-----IHKK---LHHTEDQKAEV------------------EQH 350
            ++ +L+ G  NK +EQ     + K+   L   E QK E+                  E++
Sbjct: 888  YESKLEDG--NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEY 945

Query: 351  KETLKNQIVGLEREVEASKKQAE-LDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKL 409
            +   KNQ   +E+  + +K+  E L +K +D+  + +  L    L+ ++  +KQ +  K+
Sbjct: 946  ETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE-LSQKEKQFN-AKM 1003

Query: 410  HEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVL-MNMEDI-KVRE 467
             E A+ N  G           Q++ I  L +   R +N    + +K L    E++ ++ E
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHE 1063

Query: 468  TQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVD 527
             Q+ +  +++AE    LKQ+  L+   + + N           EIT +K +       ++
Sbjct: 1064 IQLQEKEQEVAE----LKQKILLFGCEKEEMN----------KEITWLKEEGVKQDTTLN 1109

Query: 528  ELKEDISAKESALVKLHLEQQRIEKEKETLKAELQK-LRQQALETKHFIE-KQEAEERKL 585
            EL+E +  K + +  L  ++ +++   E L+ +L K L++     +  +E K  AEE K 
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK- 1168

Query: 586  LRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQY 645
             R ++E   +     +E   + S  +     L  ++ E   L E++ IQ  +  K +++ 
Sbjct: 1169 -RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK-KTEA 1226

Query: 646  NQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELE 705
                +   ++ +   K       ++       ++++        + +   + R L EE +
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE-Q 1285

Query: 706  NPLNV---HRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELK 762
            N LN+       +LE  +     +   I +L     +  +E   ++    EKE    +LK
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLK 1345

Query: 763  HVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNL 822
              L+     E    + L +  L +KK ++  LS +L    VQ +     + +    + +L
Sbjct: 1346 KELS-----ENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN-SISLSEKEAAISSL 1399

Query: 823  KKKYLAQK 830
            +K+Y  +K
Sbjct: 1400 RKQYDEEK 1407



 Score =  109 bits (273), Expect = 1e-23
 Identities = 160/820 (19%), Positives = 372/820 (45%), Gaps = 133/820 (16%)

Query: 124 KEEIVNLTKLVEQGSGLSMDQHSNI--------RDLLRFKEEVTKERDQLLSEVVKLRES 175
           KE+++   + +E+       ++S +        R+  + +  +++ +D+ L  + +LRE 
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195

Query: 176 LAQTTEQ----QQETERSKEEAEHAISQFQQEI---QQR---------------QNEASR 213
           L    +     Q+E + S EE +  IS  Q ++   +QR               Q E   
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 255

Query: 214 E-FRKKEKLEKELKQIQAD------MDSRQTEIKALQQYVQKSKEELQKLEQQL----KE 262
           E F K+E  E + + +  D      +++ Q  +K  +  +++ KE +Q  ++Q      E
Sbjct: 256 EVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315

Query: 263 QKILNERAAKELEQF----------------QMRNAK--LQQENEQHSLVCEQLSQENQQ 304
           ++ L E+  + L++                 Q+R+AK  ++Q  +   +V   +++  +Q
Sbjct: 316 KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV---IAETKRQ 372

Query: 305 KALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETL----KNQIVG 360
               L+ KEEE+ Q+R  I ++    E++ ++   +E  +A  E+ ++ L    K +   
Sbjct: 373 MHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSE--RAAFEELEKALSTAQKTEEAR 430

Query: 361 LEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTD-----LVKLHEQA-- 413
            + + E  ++   +++ + +E +  +  L++   + V+  +K ++     L KLHE+   
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA 490

Query: 414 --KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIF 471
             ++ L  ++Q  + E Q+Q K+   LEK +  Y+  + +  Q+  + +E++++++  I 
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVA--LEKSQSEYLKISQEKEQQESLALEELELQKKAI- 547

Query: 472 DYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKE 531
                + ESE KL+  Q   E  R+               I +++  L+  + +     +
Sbjct: 548 -----LTESENKLRDLQQEAETYRT--------------RILELESSLEKSLQENKNQSK 588

Query: 532 DISAKESALVKLHLEQQRIEKEKE-TLKAELQKLRQQALETKHFIEKQEAEERKLLRIIA 590
           D++        +HLE ++ +  KE T+  E  K   ++L  KH  +    E+ ++L+   
Sbjct: 589 DLA--------VHLEAEKNKHNKEITVMVEKHKTELESL--KHQQDALWTEKLQVLKQQY 638

Query: 591 EADGERLRQK--KELDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQR 648
           + + E+LR+K  +E + ++ +++I+    +   +E  L  EK+ ++Q+ L    S+ ++ 
Sbjct: 639 QTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL--EKLDVKQTELESLSSELSEV 696

Query: 649 L-------EDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALE 701
           L       E++ +L+ +  K+++E         N  + + +    + E+  +RT  +AL+
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE-KALK 755

Query: 702 EELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQ-------EK 754
           +++     + + R     +  A+  ++ +    KR   + ++   K  + Q       E+
Sbjct: 756 DQINQLELLLKERDKHLKEHQAH--VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQ 813

Query: 755 EKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEK 814
            K Y E    L ++      E++ L ++    + Q+ K + +EL+ +++Q ++   ++EK
Sbjct: 814 TKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK-KDVCTELDAHKIQVQDLMQQLEK 872

Query: 815 LTNELQNLKKKYLAQKRKEQLQKNKDTAPMDNTFLMVKPN 854
             +E++  K K L Q  + +L+            L+ K N
Sbjct: 873 QNSEMEQ-KVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911



 Score =  104 bits (260), Expect = 3e-22
 Identities = 182/898 (20%), Positives = 375/898 (41%), Gaps = 162/898 (18%)

Query: 3    EEKGGKQVLEESAF------EEMERDFQGVLHELSG-DKSLEKFRIEYERLHAVMKKSYD 55
            E++  KQ+L E         E  +++ + +  +LS  + S+     EYE         + 
Sbjct: 898  EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYET-------KFK 950

Query: 56   NEKRLMAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQK 115
            N+++ M K ++        + ++   LK    DQ   A LKKE+E      ++A +  QK
Sbjct: 951  NQEKKMEKVKQ-------KAKEMQETLKKKLLDQE--AKLKKELE------NTALELSQK 995

Query: 116  AKETILALKEEI-VNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRE 174
             K+    + E    N   + +  S L  +Q   I       E +T+   + L++V+ + E
Sbjct: 996  EKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI-------ESLTEVHRRELNDVISIWE 1048

Query: 175  SLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS 234
                  +  Q+ E  +E  E  + + +QE+ + + +      +KE++ KE+  ++ +   
Sbjct: 1049 K-----KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVK 1103

Query: 235  RQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLV 294
            + T +  LQ+ +++    +  L Q   + K   E+   +L +    N  LQ++  +  ++
Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163

Query: 295  CEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKA--------E 346
             E+  ++  +   +LK  +EE   ++    K NK  E    +     ++ A        +
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223

Query: 347  VEQHKETLKNQIVGLEREVEASKKQAELDR--------------------------KAMD 380
             E   E   N+++     + +SK  A L R                            + 
Sbjct: 1224 TEALLEAKTNELI----NISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279

Query: 381  ELLRERDILNKNMLKAVNATQKQTDLVKLHE-------QAKRNLEGEIQNYKDEAQKQRK 433
            +L  E++ LN +  +A +  +++ + +K  +         K  L+ E  N +  A ++  
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339

Query: 434  IIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYE- 492
             I  L+KE    IN        V +  E++K ++ +I    K++ +  ++L+   +L E 
Sbjct: 1340 CITQLKKELSENIN-------AVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392

Query: 493  --AVRSDRNLYSKNLVEAQDEITDMKRKLKIM-------IHQVDELKEDISA-KESALVK 542
              A+ S R  Y +   E  D++ D+  K+  +       + QVD+     S  K+ A   
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA--- 1449

Query: 543  LHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKE 602
                Q R  + + T+K ELQ   Q  L++K   EK   E+  LL             K+E
Sbjct: 1450 ----QSRFTQHQNTVK-ELQ--IQLELKSKEAYEKD--EQINLL-------------KEE 1487

Query: 603  LDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKL 662
            LDQ              +N     L  +++  +S + K ES     L+      +E++  
Sbjct: 1488 LDQ--------------QNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533

Query: 663  RREKGILARSMANV-EELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDP 721
              +K I   S+  V +   Q+     +EL+++    + L EE +N        +++ ++ 
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN--------RVKEAEE 1585

Query: 722  NAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYR 781
                L  ++++++  L +K +E+    L ++ KE+   ELK +  R     AA+  +L R
Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKEE---ELKALEDRLESESAAKLAELKR 1642

Query: 782  RTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNK 839
            +     +Q++  +  +L + +++ KE +Y+ +   + L  L  K   ++R+  + + K
Sbjct: 1643 KA----EQKIAAIKKQL-LSQMEEKEEQYK-KGTESHLSELNTKLQEREREVHILEEK 1694



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 145/720 (20%), Positives = 322/720 (44%), Gaps = 80/720 (11%)

Query: 2    AEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRLM 61
            A EK  +  L +   ++  + F  +  E+  DKS  K   +   L   +K          
Sbjct: 1474 AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKS--KMEKKESNLETELKSQ-------T 1524

Query: 62   AKCRELNAEIVVNSAKVATALKLSQD-DQTTIASLKKEIEKAWKMVDSAYDKEQKAKET- 119
            A+  EL   I   + ++ +  ++ ++ +Q      K+ ++K     +   +K+ + KE  
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584

Query: 120  --ILALKEEIVNLTKLVE----QGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLR 173
              IL L+ ++ ++   +E    +   +++   S   +L   ++ +  E    L+E+ +  
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644

Query: 174  ESLAQTTEQQ------QETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQ 227
            E      ++Q      ++ E+ K+  E  +S+   ++Q+R+ E          LE++LK 
Sbjct: 1645 EQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREV-------HILEEKLKS 1697

Query: 228  IQADMDSR---QTEIKALQQYVQKSKEELQKLEQQLKEQKI-LNERAAKELEQFQMRNAK 283
            +++            K +  Y ++ + + Q   Q+  E+KI + +R   E E+   R   
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR--- 1754

Query: 284  LQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQ 343
            + QE E+      ++  + Q++ ++L+  E + H+ +  IG L +  E+ +KK      Q
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQ 1814

Query: 344  KAEVEQHKETL--KNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQ 401
              E E  K  +  K  +  +  +V+ + ++ EL  + +++ ++E D        +    Q
Sbjct: 1815 HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELD--------SCLVRQ 1866

Query: 402  KQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQ-KVLMNM 460
            K+   V++ E   +  + +     D   K  +++    +E+ +     S L Q K+L NM
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSK-----SHLVQPKLLSNM 1921

Query: 461  EDIKVRETQIFDYRKKIAESEIKLKQQQNL-YEAVRSDRNLYSKNLVEAQDEITDMKRKL 519
            E       Q  D   K+A +E   +++Q L  E VR  ++L      E Q E+  +K++ 
Sbjct: 1922 E------AQHNDLEFKLAGAE---REKQKLGKEIVRLQKDLRMLRK-EHQQELEILKKEY 1971

Query: 520  -KIMIHQVDELKEDISAKESALVKLHLEQ---QRIEKEKE---TLKAELQKLRQQALETK 572
             +    ++ + +ED+  K ++ +K  + +   Q  +KE+E   T+K  + K ++   E  
Sbjct: 1972 DQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE-- 2029

Query: 573  HFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIK 632
              +E  + E  +LL+ IAE D +  R  K  ++++  R+    ++  +  +L    E  +
Sbjct: 2030 -LLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE---EEMTAKVRDLQTQLE--E 2083

Query: 633  IQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLK 692
            +Q+    K E + N   +++ I+ L+  +L ++  +++ S    +E R++  +++  L K
Sbjct: 2084 LQKKYQQKLEQEENPGNDNVTIMELQ-TQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 129/659 (19%), Positives = 279/659 (42%), Gaps = 81/659 (12%)

Query: 215 FRK-KEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKE 273
           F+K K+K+ +E +Q+Q  +   Q    +      +S+       +QL E     E    +
Sbjct: 2   FKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTS--SFTEQLDEGTPNRESGDTQ 59

Query: 274 --LEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIRE 331
              ++ Q+R   +  E+   S + E L + + +++L   +  E ++++ LD    +    
Sbjct: 60  SFAQKLQLRVPSV--ESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTAS---- 113

Query: 332 QIHKKLHHTEDQKAEVEQ--------HKETLKNQIVGLEREVEASKKQAELDRKAMDELL 383
                     D  +E E         +KE L  ++  +ER + + + +      A   L 
Sbjct: 114 -----FDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQ 168

Query: 384 RERD----ILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKII---F 436
           RE+     IL+++  K++    +  + +++ +QAK++L+ E     +E  +   ++    
Sbjct: 169 REKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQV 228

Query: 437 HLEKERDRYINQASDLTQKV--LMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAV 494
            L K+R R      D+ + +  L    ++  +E       + + E    +K  + L + V
Sbjct: 229 SLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288

Query: 495 RSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEK 554
           +   NL    L   ++ I   K +  ++  + + L+E +  +           Q +EK K
Sbjct: 289 KRQENL----LKRCKETIQSHKEQCTLLTSEKEALQEQLDER----------LQELEKIK 334

Query: 555 ETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILG 614
           +   AE  KL  Q  + K+ IE+ E ++     +IAE        K+++ + +  ++   
Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKG---MVIAET-------KRQMHETLEMKEEEI 384

Query: 615 SQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRRE-KGILARSM 673
           +QL  R  ++    E+++ Q+    K E    + LE       + ++ RR+ K  +   +
Sbjct: 385 AQLRSRIKQMTTQGEELREQK---EKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQI 441

Query: 674 ANVEEL-RQEFFHMQRELLKERTRC-----RALEEELENPLNVHRWRKLEASDPNAYELI 727
             +E+   +E   +Q+EL + +        ++ EE++     +H             EL 
Sbjct: 442 KTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE-----------KELA 490

Query: 728 QKIHTLQKRLISKTEEVVEK-ELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRT-LH 785
           +K   L K+L ++  E  E+ ++ L++ +  Y+++     +Q    A E+L+L ++  L 
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQES-LALEELELQKKAILT 549

Query: 786 DKKQQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKEQLQKNKDTAPM 844
           + + +L+ L  E   Y  +  E +  +EK   E +N  K        E+ + NK+   M
Sbjct: 550 ESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM 608


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score =  127 bits (319), Expect = 4e-29
 Identities = 179/875 (20%), Positives = 398/875 (45%), Gaps = 112/875 (12%)

Query: 33   DKSLEKFRIEYERLHAVMKKSYDNEKRLMAKCRE---LNAEI----------VVNSAKVA 79
            +K++E  R   ER   ++++  ++  + ++  R+   ++AE           +++ +   
Sbjct: 539  EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598

Query: 80   TALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA----KETILALKEEIVNLTKLVE 135
            T+ KLS+ +      +KKE+E   +  + A + E +     KE  L L+++I NL    E
Sbjct: 599  TSSKLSKIEFEK-RQIKKELEHYKEKGERAEELENELHHLEKENEL-LQKKITNLKITCE 656

Query: 136  QGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEH 195
            +   L  +     R+  + K+ +   ++ L  ++  L +  +Q  E+  E  R+ E  + 
Sbjct: 657  KIEALEQENSELERENRKLKKTLDSFKN-LTFQLESLEKENSQLDEENLELRRNVESLKC 715

Query: 196  AISQFQQ-EIQQRQNEASREFRKK--EKLE---KELKQIQADMDSRQTEIKALQQYVQKS 249
            A  +  Q +++ ++ E+ +E  KK  E L+   K+ ++++        E + LQ+ ++ S
Sbjct: 716  ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775

Query: 250  KEELQKLEQQLKEQKILNER----------AAKELEQFQMRNAKLQQENEQHSLVCEQLS 299
             +++Q+LE +L++ ++ N+           ++K LEQ +  N  L+QE  Q     +QL 
Sbjct: 776  NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835

Query: 300  QENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQ----KAEVEQHKETLK 355
            +EN++   + + K+  + +  + IG L K  + + K++   ++     K   +++KE +K
Sbjct: 836  KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895

Query: 356  ------NQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKL 409
                    +V L  ++ + K + +     +++L  E + +  N  + ++  Q   D  KL
Sbjct: 896  RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL 955

Query: 410  HEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQ 469
             E     LE  ++   +  +++   +    +E   Y  Q     + V  N E +K R+ +
Sbjct: 956  LES---KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1012

Query: 470  IFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDEL 529
                 +++ +S   +  + N +E    +    ++ L++ +D + +++R    +  +   L
Sbjct: 1013 -----ERMVQSSPPISGEDNKWERESQET---TRELLKVKDRLIEVERNNATLQAEKQAL 1064

Query: 530  KEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ--EAEERKLLR 587
            K  +   E+     +L+ Q +  +++T+  + Q    Q    K  +E     ++   L+ 
Sbjct: 1065 KTQLKQLETQ--NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1122

Query: 588  IIAEADGERLRQKKELDQVISERDILGS---QLVRRNDELALLYEKIKIQ-QSVLNKG-- 641
              A+   ++   + E + VI ER+ L S    L++ +++L LL+E+   + +S+++K   
Sbjct: 1123 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1182

Query: 642  ---------------ESQYNQ------RLEDM-RILRLEIKKLRREKGILARSMANVEEL 679
                           E +YNQ      +LED+ ++L++E +K+  E        A  ++L
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1242

Query: 680  ---RQEFFHMQRELLKERTRCRALEEELENPLNVHRWR--KLEASDPNAYELIQKIHTLQ 734
                    H   +LLKE    +   + L++ LN  +    +LEA      E  Q++    
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD--- 1299

Query: 735  KRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL 794
               I+ T+   + ELL Q K  L  E +H+L      +  + L L  RTL ++  + K  
Sbjct: 1300 ---ITSTKLNNQCELLSQLKGNLEEENRHLL------DQIQTLMLQNRTLLEQNMESK-- 1348

Query: 795  SSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQ 829
                +++ V+ ++Y  ++ +L  + + L++K + Q
Sbjct: 1349 ----DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379



 Score =  122 bits (306), Expect = 1e-27
 Identities = 191/911 (20%), Positives = 366/911 (40%), Gaps = 126/911 (13%)

Query: 4    EKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL--- 60
            EK   Q+  +    EMERD           K +E+   E   L    K+S D    L   
Sbjct: 381  EKENLQLKAKLHDMEMERDMDR--------KKIEELMEENMTLEMAQKQSMDESLHLGWE 432

Query: 61   ---------MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYD 111
                     +++  + +    VN    +  LKL  ++Q    SL K +E+    VDS   
Sbjct: 433  LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ----SLTKTVEELRTTVDSVEG 488

Query: 112  KEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVK 171
               K    IL +++E   L+K VE      + +  ++++     +++ KE+ QL   +  
Sbjct: 489  NASK----ILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544

Query: 172  LRES-------LAQTTEQQQET-----ERSKEEAEHAISQFQQEIQQRQNEASREFRKKE 219
            LRE+       L Q  E   +T     +RS+  AE  +   ++E +           K  
Sbjct: 545  LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604

Query: 220  KLEKELKQIQADMD------SRQTEIKALQQYVQKSKEELQK--------------LEQQ 259
            K+E E +QI+ +++       R  E++    +++K  E LQK              LEQ+
Sbjct: 605  KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664

Query: 260  LKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQEN---QQKALELKAKEEEV 316
              E +  N +  K L+ F+    +L+   +++S    QL +EN   ++    LK    ++
Sbjct: 665  NSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVESLKCASMKM 720

Query: 317  HQMRLDIGKLNKIREQIHK-----KLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQ 371
             Q++L+  +L   +EQ+ K     K    + ++ EV      ++NQ   L++ +E S K+
Sbjct: 721  AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ--RLQKTLENSNKK 778

Query: 372  AELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQ 431
             +     + +L  E   L KN+           + +K+  +    LE E ++ + E  + 
Sbjct: 779  IQQLESELQDLEMENQTLQKNL-----------EELKISSKRLEQLEKENKSLEQETSQL 827

Query: 432  RKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIA---ESEIKLKQQQ 488
             K    LEKE  R   QA      +  N   I   E +     K+I    ES ++LK+ +
Sbjct: 828  EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887

Query: 489  NLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI--------------- 533
               + +     +  K LV  ++++   K K + M + +++L  ++               
Sbjct: 888  KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947

Query: 534  ----------SAKESALVK-LHLEQQRIEKEKETLKAEL---QKLRQQALETKHFIE--K 577
                      S  ES L K L +++++I   +  L+      Q+LRQ+    K   E  K
Sbjct: 948  STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007

Query: 578  QEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEKIKIQQSV 637
            Q  +E ++++      GE  + ++E  +   E   +  +L+      A L  + +  ++ 
Sbjct: 1008 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067

Query: 638  LNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRC 697
            L + E+Q N     +  L+ +   L+ +   L    A ++            L+ +  + 
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127

Query: 698  RALEEELENPLN--VHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKE 755
               +  LEN     +     L++   +  +  +K+  L +R  S+ E ++ K   L+   
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187

Query: 756  KLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKL 815
            K  +E++H    +   +   QL   +  L D ++ LKV   ++ +     +    E +KL
Sbjct: 1188 K-NLEVEH----RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1242

Query: 816  TNELQNLKKKY 826
              E   L   Y
Sbjct: 1243 CGENDRLNHTY 1253



 Score =  114 bits (286), Expect = 3e-25
 Identities = 166/779 (21%), Positives = 341/779 (43%), Gaps = 100/779 (12%)

Query: 123 LKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQT--- 179
           LK   ++L +L+++      D+HS          E+++ERD L    +    S AQ+   
Sbjct: 190 LKNMALHLKRLIDE-----RDEHSETII------ELSEERDGL--HFLPHASSSAQSPCG 236

Query: 180 ------TEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMD 233
                 TE +Q       +A+  I + +QE++++  +     ++ E++E ELK++Q +  
Sbjct: 237 SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENM 296

Query: 234 SRQTEIKALQQYVQKSKEELQKL-EQQLKEQKILNE--RAAKELEQFQMRNAKLQQENEQ 290
           +  ++ ++ + Y    ++EL  L E+ ++  K+ +E  R  + L   +   A++++  E 
Sbjct: 297 NLLSDARSARMY----RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352

Query: 291 HSLVCEQLSQENQQ------KALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQK 344
           + ++ E  +    Q      ++ +L   E+E  Q++  +  +   R+   KK+    ++ 
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412

Query: 345 AEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRE-RDILNKNMLKAVNATQKQ 403
             +E  ++   ++ + L  E+E   + +EL       L  E  ++ +  +LK     Q  
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472

Query: 404 TDLVKLHEQAKRNLEG---EIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNM 460
           T  V+       ++EG   +I   + E Q+  K +  LE E  +   Q+    Q +  ++
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE-KQSLQNCQNLSKDL 531

Query: 461 EDIKVRETQIFDYRKKIAESEIKLKQQQN--LYEAVRSDRNLYSKNLVEAQDEITDMKRK 518
              K +  +  +  ++ +E +IK+ +Q+N  L + V S   L  ++ + A+  + D++++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS---LRQRSQISAEARVKDIEKE 588

Query: 519 LKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQ 578
            KI       L E I    S L K+  E+++I+KE E  K + ++  +   E  H  ++ 
Sbjct: 589 NKI-------LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641

Query: 579 EAEERKLLRI-------------IAEADGERLRQKKELDQV------ISERDILGSQLVR 619
           E  ++K+  +              +E + E  + KK LD        +   +   SQL  
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 620 RNDELALLYEKIK------IQQSVLNKG-ESQYNQRLEDMRILRLEIKKLRREKGILARS 672
            N EL    E +K       Q  + NK  ES+  Q  + + +L+   KK  R +      
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE------ 755

Query: 673 MANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHT 732
             + + L  E   +Q+ L     + + LE EL++         LE  +    + ++++  
Sbjct: 756 -VSYQGLDIENQRLQKTLENSNKKIQQLESELQD---------LEMENQTLQKNLEELKI 805

Query: 733 LQKRL--ISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQ 790
             KRL  + K  + +E+E    EK+K  +E ++   RQ        L+     + + +++
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865

Query: 791 LKVLSSELNMYEVQSKEYKYEVEKLTNEL---QNLKKKYLAQKRKEQLQKNKDTAPMDN 846
            K LS E+ +Y+      K E+EK   EL     +  K L   R++ + +   T  M+N
Sbjct: 866 NKTLSKEIGIYKESCVRLK-ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score =  126 bits (317), Expect = 8e-29
 Identities = 185/926 (19%), Positives = 393/926 (42%), Gaps = 139/926 (15%)

Query: 1    MAEEKGGKQVLEESAFEEMERDFQGVLHELSGDKSLEKFRIEYERLHAVMKKSYDNEKRL 60
            + +EK G  V++++  +  + +   ++H+L           E ++L A +K+     K  
Sbjct: 307  LLKEKSG--VIQDALKKSSKGELTTLIHQLQ----------EKDKLLAAVKEDAAATKD- 353

Query: 61   MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
              +C++L  E++    +    +   +D    I +L+KE       +  +Y + Q+ +   
Sbjct: 354  --RCKQLTQEMMTEKERSNVVITRMKD---RIGTLEKEHNVFQNKIHVSYQETQQMQMKF 408

Query: 121  LALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTT 180
              ++E++      ++Q +G+  D  SN  + L  K+    E ++L  +  +L   L + T
Sbjct: 409  QQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA--ELNKLRQDYARLVNELTEKT 466

Query: 181  EQQQETERSKEEAEHAISQFQQEIQQ--RQNEASREFRKKEKLEKELKQ--IQADMDSRQ 236
             + Q+ E  K+ AE A +Q + ++Q+  R+ E  + + +K   E E  Q  +Q+   +++
Sbjct: 467  GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526

Query: 237  TEIKALQQYVQKSKEELQKLEQQL-----KEQKILNERAAKE------LEQFQMRNAKLQ 285
             E+++L   +  +    Q+LEQ+L      EQK +N+  + +      LEQ +   A++Q
Sbjct: 527  NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586

Query: 286  QENEQ--------------HSLVCE---QLSQENQQKALE---LKAKEEEVHQMRLDIGK 325
            Q + Q              H ++ E   Q+ Q     A E   L +KEEE+     DI  
Sbjct: 587  QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK----DIQN 642

Query: 326  LNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRE 385
            +N + +   +KL    +++A      E ++  +   + ++   ++Q + +   +   + E
Sbjct: 643  MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE---ISNKMEE 699

Query: 386  RDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHL------- 438
              ILN       +  QK   LV   EQ  +++  +++    E  ++ K +  L       
Sbjct: 700  FKILNDQNKALKSEVQKLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQ 757

Query: 439  ----EKERDRYINQASDLTQKVLMNMEDIKVRETQ-------IFDYRKKIAESEIKLKQQ 487
                E+E +    + S LT++V    +D+K ++         + + +K I E + K+K  
Sbjct: 758  VATKEEELNAIRTENSSLTKEV----QDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813

Query: 488  QNLYEA-VRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLE 546
            + L EA +    N      +    ++ +++  LK    Q++ +K  +  KE  L      
Sbjct: 814  EELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 873

Query: 547  QQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQV 606
             Q +++E E+LKA +Q++ Q  L+                      +     Q +EL+ V
Sbjct: 874  LQDLQEENESLKAHVQEVAQHNLK----------------------EASSASQFEELEIV 911

Query: 607  ISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREK 666
            + E++          +EL  L   +K ++S L+          ++ ++ + +I++L+++ 
Sbjct: 912  LKEKE----------NELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN 961

Query: 667  GILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYEL 726
               A S    EEL +     ++E+        +L++ +E     H+ +K        +E 
Sbjct: 962  YQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE-----HQRKKNNDLREKNWEA 1016

Query: 727  IQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH- 785
            ++ + + +K L  K  +  ++    Q+ E + +E K VL +     +      Y   LH 
Sbjct: 1017 MEALASTEKMLQDKVNKTSKERQ--QQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1074

Query: 786  -DKK-----------QQLKVLSSELNMYEVQSKEYKYEVEKLTNELQNLKKKYLAQKRKE 833
             +KK           +++KVL  +L   +      + E EK  + L   +      +R  
Sbjct: 1075 FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV 1134

Query: 834  QLQKNKDTAPMDNTFLMVKPNGPGFT 859
            + ++NK    +D +   +K     FT
Sbjct: 1135 EQEENKWKVKVDESHKTIKQMQSSFT 1160



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 161/821 (19%), Positives = 335/821 (40%), Gaps = 143/821 (17%)

Query: 86   QDDQTTIASLKKEIEKAW-KMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQ 144
            QD Q+   + + E++    K+ D+   K+Q  +  +  ++ E     K V +   L M  
Sbjct: 516  QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESE----QKRVNKEESLQMQ- 570

Query: 145  HSNIRDLLRFKEEVTKERDQLLSEVV----------KLRESLAQTTEQQQETERSKEEAE 194
               ++D+L   E +  +  Q  S++           +L + +A+  +Q ++TE S     
Sbjct: 571  ---VQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER 627

Query: 195  HAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQ 254
              ++  ++E++  QN     F  K +++K L+ +  +  +   E++ +QQ V    ++++
Sbjct: 628  DRLTSKEEELKDIQN---MNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683

Query: 255  KLEQQLKEQ--------KILNER-AAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQK 305
             LE+QL+ +        KILN++  A + E  +++    +Q N+      E+  QE  +K
Sbjct: 684  LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743

Query: 306  A-----------LELKAKEEEVHQMRLDIGKLNK-----------------IREQIHKKL 337
                        +++  KEEE++ +R +   L K                 + E++ K +
Sbjct: 744  LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVI 803

Query: 338  HHTEDQKAEVEQ-----------HKETLKNQIVGLEREVEASKKQAELDRKAMDELLRER 386
            H  + +   VE+            ++T++  I    +E++   K  E     M  +L E+
Sbjct: 804  HEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEK 863

Query: 387  DILNKNMLKAVNATQKQTDLVKLHEQ--AKRNLEG--------EIQNYKDEAQKQRKIIF 436
            +    N  K +   Q++ + +K H Q  A+ NL+         E++    E + + K + 
Sbjct: 864  EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 923

Query: 437  HLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRS 496
             + KER+  ++  + L Q V    ++ K+ ++QI   +++  +        + L + + S
Sbjct: 924  AMLKERESDLSSKTQLLQDV---QDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI-S 979

Query: 497  DRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKET 556
            +R    K +    +E+  +K  ++    + ++L+E       AL     E+   +K  +T
Sbjct: 980  ERE---KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALAST--EKMLQDKVNKT 1034

Query: 557  LKAELQKLRQQALETKHFIEKQEAE----------------ERKLLRIIAEADGERLRQK 600
             K   Q++    LE K  ++K   +                E+K    +A   G    + 
Sbjct: 1035 SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE--EV 1092

Query: 601  KELDQVISERDILGS--------------------QLVRRNDELALLYEKIKIQQS--VL 638
            K L+  + E D + +                    Q ++R+ E      K+K+ +S   +
Sbjct: 1093 KVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTI 1152

Query: 639  NKGESQYN---QRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERT 695
             + +S +    Q LE +R    +I+ LRRE+  L   +   E  R  +    REL  +  
Sbjct: 1153 KQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQ-- 1210

Query: 696  RCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEE--VVEKELLLQE 753
                L E L         R+  A D   ++  Q +  +Q +++    +  V+E   +  E
Sbjct: 1211 ----LNETLTKLRTEQNERQKVAGD--LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1264

Query: 754  KEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVL 794
             E    E   V   Q   +  + L+   + L  +K+  +VL
Sbjct: 1265 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVL 1305



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 111/562 (19%), Positives = 246/562 (43%), Gaps = 62/562 (11%)

Query: 59   RLMAKCRELNAEIVVNSA--KVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKA 116
            ++  K  ELNA    NS+  K    LK  Q+DQ + ASL +E++K        ++K+ K 
Sbjct: 757  QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV------IHEKDGKI 810

Query: 117  KETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESL 176
            K     L+ E++ +    +        +   +++LL+ KEE       +L E  K    L
Sbjct: 811  KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEK---DL 867

Query: 177  AQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASR----EFRKKEKLEKELKQIQADM 232
            A T +  Q+ +   E  +  + +  Q   +  + AS+    E   KEK E ELK+++A +
Sbjct: 868  ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAML 926

Query: 233  DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHS 292
              R++++ +  Q +Q  ++E +  + Q+++ K  N + A      +     + +  ++ S
Sbjct: 927  KERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEIS 986

Query: 293  LVCEQLS------QENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAE 346
             +  +L       +  ++K  +L+ K  E  +      K+  ++++++K     + Q   
Sbjct: 987  GLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM--LQDKVNKTSKERQQQVEA 1044

Query: 347  VE-QHKETLKNQ---------------IVGLEREVEA--SKKQAELDRKAMDELLRERDI 388
            VE + KE LK                 + G E++ +   +      + K ++  L+E D 
Sbjct: 1045 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADE 1104

Query: 389  LNKNM-LKAVNATQKQTDLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHL-------EK 440
            ++  + L+         +   + ++ +R++E E   +K +  +  K I  +       E+
Sbjct: 1105 MHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ 1164

Query: 441  ERDRYINQASDLT------QKVLMNMEDIKVRE----TQIFDYRKKIAESEIKLKQQQNL 490
            E +R  ++  D+       + + M +E  ++      T++ + + ++ E+  KL+ +QN 
Sbjct: 1165 ELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNE 1224

Query: 491  YEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRI 550
             + V  D +   ++L   Q +I        ++ +     + + S KE+  V L+    ++
Sbjct: 1225 RQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQL 1284

Query: 551  EKEKETLKAELQKLRQ--QALE 570
            ++  + +  +L K ++  Q LE
Sbjct: 1285 QQLLQAVNQQLTKEKEHYQVLE 1306



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 71/401 (17%), Positives = 159/401 (39%), Gaps = 69/401 (17%)

Query: 42   EYERLHAVMKKSYDNEKRLMAKCRELNAEI-----VVNSAKVATALKLSQDDQT------ 90
            ++E L  V+K+  +  KRL A  +E  +++     ++   +    L  SQ +Q       
Sbjct: 904  QFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQ 963

Query: 91   -------------TIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQG 137
                          I+  +KEI   W  +DS  D  +  ++    L+E+     + +   
Sbjct: 964  QASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALAST 1023

Query: 138  SGLSMDQ-HSNIRDLLRFKEEVTKERDQLLSEVV--------------------KLRESL 176
              +  D+ +   ++  +  E V  E  ++L ++                     K +E +
Sbjct: 1024 EKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1083

Query: 177  AQTT--EQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQ----A 230
            A T+  E+ +  E   +EA+   +  Q E ++ ++  +      +KL++ ++Q +     
Sbjct: 1084 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKV 1143

Query: 231  DMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQ 290
             +D     IK +Q     S++EL++L  + K+     E   +E E  +M   K + E   
Sbjct: 1144 KVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAEMERST 1199

Query: 291  HSLVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHT---------- 340
            +     +L  +  +   +L+ ++ E  ++  D+ K  +  E I  K+             
Sbjct: 1200 YVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1259

Query: 341  ----EDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRK 377
                E + +E E    +L   +  L++ ++A  +Q   +++
Sbjct: 1260 DVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1300


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,283,239
Number of Sequences: 37866
Number of extensions: 1302245
Number of successful extensions: 36850
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 830
Number of HSP's successfully gapped in prelim test: 1390
Number of HSP's that attempted gapping in prelim test: 8092
Number of HSP's gapped (non-prelim): 10455
length of query: 872
length of database: 18,247,518
effective HSP length: 111
effective length of query: 761
effective length of database: 14,044,392
effective search space: 10687782312
effective search space used: 10687782312
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.