Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 56711324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56711324 HAUS augmin-like complex, subunit 3 [Homo sapiens]
(603 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56711324 HAUS augmin-like complex, subunit 3 [Homo sapiens] 1172 0.0
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 68 2e-11
gi|55770834 centromere protein F [Homo sapiens] 61 3e-09
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 59 1e-08
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 57 4e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 57 6e-08
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 57 6e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 56 1e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 56 1e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 55 2e-07
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 55 2e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 54 3e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 3e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 3e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 3e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 3e-07
gi|110815815 centlein isoform 1 [Homo sapiens] 53 7e-07
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 52 1e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 52 2e-06
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 52 2e-06
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 51 3e-06
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 51 3e-06
gi|149363642 coiled-coil domain containing 144A [Homo sapiens] 51 3e-06
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 51 3e-06
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 51 3e-06
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 51 3e-06
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 50 5e-06
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 50 6e-06
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 50 6e-06
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 50 8e-06
>gi|56711324 HAUS augmin-like complex, subunit 3 [Homo sapiens]
Length = 603
Score = 1172 bits (3033), Expect = 0.0
Identities = 603/603 (100%), Positives = 603/603 (100%)
Query: 1 MSCGNEFVETLKKIGYPKADNLNGEDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEA 60
MSCGNEFVETLKKIGYPKADNLNGEDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEA
Sbjct: 1 MSCGNEFVETLKKIGYPKADNLNGEDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEA 60
Query: 61 FSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRR 120
FSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRR
Sbjct: 61 FSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRR 120
Query: 121 NKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFF 180
NKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFF
Sbjct: 121 NKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFF 180
Query: 181 RHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQL 240
RHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQL
Sbjct: 181 RHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQL 240
Query: 241 LDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSL 300
LDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSL
Sbjct: 241 LDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSL 300
Query: 301 TSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQI 360
TSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQI
Sbjct: 301 TSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQI 360
Query: 361 AKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY 420
AKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY
Sbjct: 361 AKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY 420
Query: 421 KQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQ 480
KQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQ
Sbjct: 421 KQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQ 480
Query: 481 NISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLN 540
NISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLN
Sbjct: 481 NISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLN 540
Query: 541 KLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVS 600
KLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVS
Sbjct: 541 KLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVS 600
Query: 601 LED 603
LED
Sbjct: 601 LED 603
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 68.2 bits (165), Expect = 2e-11
Identities = 116/610 (19%), Positives = 255/610 (41%), Gaps = 87/610 (14%)
Query: 57 ELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLK 116
E E S+ Q+ + ++ +D K+ + K +L +KEL + E E+ L+ + +
Sbjct: 449 EEERISLQQELSR--VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506
Query: 117 IQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQL 176
Q + K L S + + + KE++ + L++ + A++T+ N+L+ L E
Sbjct: 507 FQEQMKVALEKSQSEYLKIS-QEKEQQESLALEELELQKKAILTESENKLRDLQQEA--- 562
Query: 177 MMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYT---KKQFFQGIHEVVESS 233
+ + + SLEK L + + + L ++ K + + I +VE
Sbjct: 563 ----------ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKH 612
Query: 234 NEDNFQLLDIQTPSICDNQEILEER-RLEMARLQLAYICAQHQLIHLKASNSSMKSSIK- 291
+ L Q + ++L+++ + EM +L+ C Q + LK ++ I+
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK--CEQEKETLLKDKEIIFQAHIEE 670
Query: 292 WAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRS---------------- 335
E++L L K + E+L +++S + KLE+E++ +KD++
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 336 -----LPAVVRENA------------QLLNMPVVKGDFDLQIAKQDYYT-------ARQE 371
+ ++++E+ Q+ + ++ + D + + + R E
Sbjct: 731 HHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790
Query: 372 LVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSV 431
L Q + F+ Q + + + + + QL+ + +L ++L KQ+ +
Sbjct: 791 GELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVE---- 846
Query: 432 SQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQL-A 490
+Q+ + +D L Q LE +N + E + +L +V E ++ + Q+Q
Sbjct: 847 AQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVK--SLTQVYESKLEDGNKEQEQTKQ 904
Query: 491 VSAQEHSFFLSKR---NKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLT 547
+ ++ + L R K++++L L + + + ++E +F E ++ K+
Sbjct: 905 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Query: 548 DILADVKTK--------RKTLANN--KLHQMEREFYVYFLK----DEDYLKDIVENLETQ 593
++ +K K +K L N +L Q E++F L+ + + D V LET
Sbjct: 965 EMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN 1024
Query: 594 SKIKAVSLED 603
K + SL +
Sbjct: 1025 QKEQIESLTE 1034
Score = 46.2 bits (108), Expect = 9e-05
Identities = 115/564 (20%), Positives = 218/564 (38%), Gaps = 56/564 (9%)
Query: 66 KSGKPILEGAALDEALKTCKTSDL--KTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKC 123
+ K ++E D+ + +T +T + ++E+ +L ++ + +++ K
Sbjct: 349 RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKS 408
Query: 124 QLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKIS--------NELQALTDEVTQ 175
+ A K+L K EEA +KLK I K S EL + EV
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 176 LMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNE 235
+M + + + Q EK L+++EQ +++F + + +E S
Sbjct: 469 VMK--------KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 236 DNFQLLDIQTPSICDNQEILEERRLEMARLQLAYIC--AQHQLIHLKASNSSMKSSIKWA 293
+ + I +E E LE LQ I ++++L L+ + ++ I
Sbjct: 521 EYLK--------ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILEL 572
Query: 294 EESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVK 353
E SL S +K L +E K KE+T + ++ E L +
Sbjct: 573 ESSLEK--SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKH----KTELESLKHQQDAL 626
Query: 354 GDFDLQIAKQDYYTARQEL------VLNQLIKQKASF--ELLQLSYEIELRKHRDIYRQL 405
LQ+ KQ Y T ++L L+K K ++ E L K +L
Sbjct: 627 WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTEL 686
Query: 406 ENLVQELSQ---SNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKK 462
E+L ELS+ + L ++L +L D + + +D + H QV ++ K
Sbjct: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD--EQKNHHQQQV---DSIIK 741
Query: 463 ELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQL- 521
E ++ E+ + + L+ + +EH + D+ L Q +L
Sbjct: 742 EHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLD 801
Query: 522 -LLSDQELT-EQFHKVESQLNKLNHLLTDILAD--VKTKRKTLANNKLHQMEREFYVYFL 577
S Q T EQ E QL +L L D+ + + TK+ + + E + +
Sbjct: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Query: 578 KDEDYLKDI-VENLETQSKIKAVS 600
+ +D ++ + +N E + K+K+++
Sbjct: 862 QVQDLMQQLEKQNSEMEQKVKSLT 885
Score = 40.8 bits (94), Expect = 0.004
Identities = 109/568 (19%), Positives = 222/568 (39%), Gaps = 90/568 (15%)
Query: 57 ELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLK 116
EL+A I + LE + K + + +L+D E+ E Q L++ +N+
Sbjct: 855 ELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ-EQTKQILVEKENMI 913
Query: 117 IQRRN----KCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQA---- 168
+Q R + +++ S K ++ EE K K + + + K + E+Q
Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK-AKEMQETLKK 972
Query: 169 -LTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYT-KKQFFQGI 226
L D+ +L ++ L F ++ + S A L T +K+ + +
Sbjct: 973 KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESL 1032
Query: 227 HEVVESSNEDNFQL----LDIQTPSICDNQEI-LEERRLEMARLQLAYICAQHQLIHLKA 281
EV D + L+ Q + + EI L+E+ E+A L+ +++
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK-------QKILLFGC 1085
Query: 282 SNSSMKSSIKWAEE-------SLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDR 334
M I W +E +L+ L + K A ++SL + KL+ + ++ +
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS---AHVNSLAQDETKLKAHLEKL-EV 1141
Query: 335 SLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIE 394
L ++EN L V +L++ ++ EL ++L F+ L+ S+E
Sbjct: 1142 DLNKSLKENTFLQEQLV-----ELKMLAEEDKRKVSELT-SKLKTTDEEFQSLKSSHEKS 1195
Query: 395 LRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNT-----IDTKDYSTH 449
+ D + + L +EL+ + K+ E L + ++ IN ++ + + H
Sbjct: 1196 NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQH 1255
Query: 450 RLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDM 509
R +V K+ L + + E+ +L+Q L ++Q
Sbjct: 1256 RTTKV------KEALLIKTCTVSELEAQLRQ---LTEEQ--------------------- 1285
Query: 510 LCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQME 569
N L +S Q+ T Q + E+Q+ + + ++ + + +K N + E
Sbjct: 1286 ---------NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 570 REFYVYFLKDEDYLKDIVENLETQSKIK 597
+E + LK K++ EN+ + +K
Sbjct: 1337 KESCITQLK-----KELSENINAVTLMK 1359
Score = 40.8 bits (94), Expect = 0.004
Identities = 93/536 (17%), Positives = 208/536 (38%), Gaps = 102/536 (19%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
++EL+ LED +++ K +++R+ + Q +A++ ++ KEE+ K + L
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAE-QKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 156 NAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQ------ 209
N + + E+ L +++ + Q +V S ++ Y QEE
Sbjct: 1678 NTKLQEREREVHILEEKLKSV-------ESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730
Query: 210 --------STAALTLYTKKQFFQGIHEVVESSNEDNFQL----------LDIQTPSICDN 251
S L K++ Q + + E + +F++ L+ ++
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHED 1790
Query: 252 QEILE--ERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLH-SLTSKAVDKE 308
Q ++ + LE + + I AQH +N K +++ + + +L K + +
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQ 1850
Query: 309 NLDAKISSLTS------EIMKLEKE-----------VTQIKDRSLPA-VVRENAQ----- 345
L+ KI L S E+ ++E E + Q+ R+ P ++ EN +
Sbjct: 1851 ILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 346 -------LLNMPVVKGDFDLQIA--KQDYYTARQELVLNQ----LIKQKASFELLQLSYE 392
L NM D + ++A +++ +E+V Q +++++ EL L E
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE 1970
Query: 393 IELRKHRDIYRQLENL-------VQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKD 445
+ + I ++ E+L +++L + Q E + ++ + IN ++ +
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
Query: 446 YSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNK 505
+H+ E K++ +L+ A++ ++ + ++++ ++ L + K
Sbjct: 2031 LESHQE----ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK 2086
Query: 506 DVDMLCDTLYQGGNQLL--------------------LSDQELTEQFHKVESQLNK 541
+ GN + L +QE EQ H +E +L K
Sbjct: 2087 KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142
Score = 40.4 bits (93), Expect = 0.005
Identities = 105/561 (18%), Positives = 215/561 (38%), Gaps = 120/561 (21%)
Query: 81 LKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAK 140
+KTC S+L+ +L +L +E TL N+ Q+ QL KS++ + +
Sbjct: 1266 IKTCTVSELEA------QLRQLTEEQNTL----NISFQQATH-QLEEKENQIKSMKADIE 1314
Query: 141 ----EEEATKK----LKQSQGILNAMITKISNELQALTDEVTQLMMFFRH-----SNLGQ 187
E+EA +K +Q+ + IT++ EL + VT + + S+L +
Sbjct: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSK 1374
Query: 188 GTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPS 247
L Q S+ LS++E + ++L +KQ+ + E+++ + +F++ +
Sbjct: 1375 QLTDLNVQLQNSIS--LSEKEAAISSL----RKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428
Query: 248 IC------------------------DNQEILEERRLEMARLQLAYICAQHQLIHLKASN 283
I +Q ++E ++++ Q+ LK
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488
Query: 284 SSMKSSIKWAEESLHSLTSKAVDKE-NLDAKISSLTSEIMKLEKEVTQ--IKDRSLPAVV 340
+ + SK KE NL+ ++ S T+ IM+LE +TQ I+ SL V+
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 341 RENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRD 400
+ Y ++++ +L+++ F+ L + +++ +
Sbjct: 1549 KN-----------------------YNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE 1585
Query: 401 IYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENK 460
LEN V + K+LE + ++ +K+ L LE E+
Sbjct: 1586 KILTLENQVYSMKAELETKKKELE-----------HVNLSVKSKEEELKALEDRLESESA 1634
Query: 461 KKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQ 520
K L E+ K +Q I+ ++ QL +E + Y+ G +
Sbjct: 1635 AK--------LAELKRKAEQKIAAIKKQLLSQMEEK---------------EEQYKKGTE 1671
Query: 521 LLLSD-----QELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVY 575
LS+ QE + H +E +L + ++ L ++ + A + + + + V
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 576 FLKDEDYLKDIVENLETQSKI 596
+E + + NL + K+
Sbjct: 1732 KTYEEK-ISVLQRNLTEKEKL 1751
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 60.8 bits (146), Expect = 3e-09
Identities = 117/516 (22%), Positives = 225/516 (43%), Gaps = 63/516 (12%)
Query: 78 DEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNK--CQLMASVTSHKSL 135
DE + C LK + + L+ V+ L + L+I R N+ L A + +
Sbjct: 2313 DEKKQLCVLQQLKE---SEHHADLLKGRVENLER--ELEIARTNQEHAALEAENSKGEVE 2367
Query: 136 RLNAKEEEATKKLKQSQGILNAMIT------KISNELQALTDEVTQLMMFFRHSNLGQGT 189
L AK E T+ L+ G+ ++T ++NELQ + +++L + +S+
Sbjct: 2368 TLKAKIEGMTQSLR---GLELDVVTIRSEKENLTNELQKEQERISELEII--NSSFEN-- 2420
Query: 190 NPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSIC 249
L + EK +E+ STA L T+ + ++E V + + D + + ++
Sbjct: 2421 ----ILQEKEQEKVQMKEKSSTAMEMLQTQ---LKELNERVAALHNDQ-EACKAKEQNLS 2472
Query: 250 DNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSM-------KSSIKWAEESLHSLTS 302
E LE LE A+L A++ I L++S + + K ++ +E + L +
Sbjct: 2473 SQVECLE---LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529
Query: 303 KAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAK 362
+ D+E L +K+S + E +L KE ++ R+L + + Q+L L++ +
Sbjct: 2530 QIQDQEQLVSKLSQVEGE-HQLWKE-QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQ 2587
Query: 363 QDYYTARQELVLNQLIKQKASFELLQL-SYEIEL-RKHRDIYRQLENLVQELSQSNMMLY 420
Y EL L ++ K ++ ++ + E EL R+ ++ ++ L +ELS L
Sbjct: 2588 SSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLA 2647
Query: 421 KQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQ 480
+L++L + + K LE KK L H + E K+++
Sbjct: 2648 GELQLLLE-------------EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVRE 2694
Query: 481 NISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQ--GGNQLLLSDQELTEQFHKVESQ 538
I+ Q +L + ++H L NK ++ T + + LS Q+L + ++S
Sbjct: 2695 EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL--EIDLLKSS 2752
Query: 539 LNKLNHLL---TDILADVKTKRKTLANNKLHQMERE 571
+LN+ L T IL ++K K K ++Q+++E
Sbjct: 2753 KEELNNSLKATTQILEELK-KTKMDNLKYVNQLKKE 2787
Score = 51.6 bits (122), Expect = 2e-06
Identities = 113/556 (20%), Positives = 238/556 (42%), Gaps = 99/556 (17%)
Query: 85 KTSDLKTPRLDDKELEKLEDEVQ--------TLLKLKNLKIQRRN-KCQLMASVTSHKSL 135
K + + L DK +E LE E+Q +L +N K + K Q+ S K
Sbjct: 2143 KERERENDSLKDK-VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 136 RLN-----AKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTN 190
L+ +++E TK++++ QG L+ + K+ + ++L +E Q + +
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSE-LDKLLSSFKSLLEEKEQAEIQIKEE------- 2253
Query: 191 PLVFLSQFSLEKYLSQ-EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDI------ 243
S+ ++E +Q +E + A L ++ + + ++ E+ QL +
Sbjct: 2254 -----SKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRA 2308
Query: 244 -----QTPSICDNQEILE---------------ERRLEMARLQLAYICAQHQLIHLKASN 283
+ +C Q++ E ER LE+AR + + + + K
Sbjct: 2309 RLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE--NSKGEV 2366
Query: 284 SSMKSSIKWAEESLHSLTSKAV----DKENLDAKI--------------SSLTSEIMKLE 325
++K+ I+ +SL L V +KENL ++ SS + + + E
Sbjct: 2367 ETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426
Query: 326 KEVTQIKDRSLPAVVRENAQL--LN--MPVVKGDFDLQIAKQDYYTARQEL-------VL 374
+E Q+K++S A+ QL LN + + D + AK+ +++ E +L
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486
Query: 375 NQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQ 434
L + K ++ +LQ S +++ D ++LE +E+S+ + Q ++++ S Q
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS---Q 2543
Query: 435 INPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQ 494
+ + + K+ + +E E K + L + +L++ E L+ + ++++L ++
Sbjct: 2544 VEGEHQL-WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKM 2602
Query: 495 EHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVK 554
+ F+ K NK + L + +++ EL E+ + + N+L L +L ++K
Sbjct: 2603 DKMSFVEKVNKMTAKETE-LQREMHEMAQKTAELQEE---LSGEKNRLAGELQLLLEEIK 2658
Query: 555 T-----KRKTLANNKL 565
+ K TL N++L
Sbjct: 2659 SSKDQLKELTLENSEL 2674
Score = 40.4 bits (93), Expect = 0.005
Identities = 122/609 (20%), Positives = 229/609 (37%), Gaps = 117/609 (19%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTS--DLKTPRL--------DDKEL 99
Q++L +RE + K K E AL AL+ K +LK + ++K L
Sbjct: 571 QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
Query: 100 EKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSH----KSLRLNAKEEEATKKLKQSQGIL 155
++E E + L KI C + SH + L E + +++ +L
Sbjct: 631 TQMESEKENLQS----KINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 156 NAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALT 215
++ ++ + A E+ Q F + + N + SQ + + + + +
Sbjct: 687 DSKSVEVETQKLAYM-ELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNE 745
Query: 216 LYTKKQFFQGIHEVVES-------------SNEDNFQLLDI--QTPS--------ICDNQ 252
+ K + +Q +H ES +NED+ + L Q P+ I +
Sbjct: 746 IMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQG 805
Query: 253 EILEER---RLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTS-KAVDKE 308
+ ER RLE + Q+++ L+ S S K ++ L K +E
Sbjct: 806 SMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEE 865
Query: 309 NL-------DAKISSLTSEIMKLEKEVT---QIKDRSLPAVVRENA--QLLNMPVVKGDF 356
NL + ++ + I KL+++ + + +L A+ + QLLN V
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQA 925
Query: 357 DLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQE---LS 413
++Q K+ + L QL+ + S E ++S I L K R++E L QE L
Sbjct: 926 EIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK-----REIEELTQENGTLK 980
Query: 414 QSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRL---------------------- 451
+ N L ++ L S S N ID ++ S L
Sbjct: 981 EINASLNQEKMNLIQKSESF----ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 452 ------YQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSK--- 502
Y+ + +N K E L + E K + +++ A+EH FL+K
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLL--NECTSLCENRKNELEQLKEAF---AKEHQEFLTKLAF 1091
Query: 503 ---RNKDVDMLCDTLYQGGNQLLLSDQE--------LTEQFHKVESQLNKLNHLLTDILA 551
RN+++ + +T+ Q + +Q L ++ ++ + NK+ + D+L
Sbjct: 1092 AEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ 1151
Query: 552 DVKTKRKTL 560
+ + K +
Sbjct: 1152 ENEQLMKVM 1160
Score = 39.3 bits (90), Expect = 0.011
Identities = 107/541 (19%), Positives = 205/541 (37%), Gaps = 91/541 (16%)
Query: 94 LDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQG 153
L + L+K+++ L KLK K QR+ + + + + ++ ++ E T +++Q
Sbjct: 12 LPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71
Query: 154 I------LNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQE 207
+ L KIS+ELQ +V F+ L G + L Q L++ S+
Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVN-----FQEGQLNSGKKQIEKLEQ-ELKRCKSEL 125
Query: 208 EQSTAA------------------LTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSIC 249
E+S A T T Q++ G S ED +
Sbjct: 126 ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG------SKYEDLKEKY-------- 171
Query: 250 DNQEILEERRLE-----MARLQLAYICAQHQLIHLKASNSSMKSSI-KWAEESLHSLTSK 303
N+E+ E +RLE + + + Q + H + SS+ W +E S S
Sbjct: 172 -NKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSS 230
Query: 304 AVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQ 363
+ + S + E+EVT R Q+ FD +
Sbjct: 231 NSQRTPIRRDFS---ASYFSGEQEVTP---------SRSTLQIGKRDANSSFFDNSSSPH 278
Query: 364 --DYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYK 421
D A+ + + N++ + + + + + ++ K +++ QLE EL + +L K
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
Query: 422 QLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKK--KELFLTHGNLEEVAEKLK 479
+ L R T ST Y LE + KK ++L N E L+
Sbjct: 339 CRDELV----------RTTAQYDQASTK--YTALEQKLKKLTEDLSCQRQNAESARCSLE 386
Query: 480 QNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQL 539
Q I + + QE LS++ + L Q +L Q+ + ++++L
Sbjct: 387 QKIKEKEKEF----QEE---LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439
Query: 540 NKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAV 599
+KL + + +++ ++ KL + E+ F +K+ + + + E + + +K+
Sbjct: 440 DKLTSVKQQLENNLEEFKQ-----KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSH 494
Query: 600 S 600
S
Sbjct: 495 S 495
Score = 39.3 bits (90), Expect = 0.011
Identities = 87/409 (21%), Positives = 162/409 (39%), Gaps = 77/409 (18%)
Query: 216 LYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMAR-----LQLAYI 270
L TK + + ++V ++N L + CD+QE+L+ R+E + L++
Sbjct: 1818 LMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ--RVETSEGLNSDLEMHAD 1875
Query: 271 CAQHQLI--HLKASNSSMKSSIKWAEESLHSLTSKAVDKEN----LDAKISSLTSEIMKL 324
+ + I ++ N S K E L + S+ E+ L+A + + +E + L
Sbjct: 1876 KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCL 1935
Query: 325 EKE------VTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQ---DYYTARQELVLN 375
EK+ V + L V E QL +G+ D K D + + +
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQL------RGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 376 QLIK-QKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQ 434
+L Q +Q++ E E+++ ++ + L + V EL + L ++L+ L
Sbjct: 1990 ELESHQSECLHCIQVA-EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL-------- 2040
Query: 435 INPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE-EVAEKLKQNISLVQDQLAVSA 493
E + L LT LE ++A+ K+ LV++ ++ A
Sbjct: 2041 -----------------------EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQA 2077
Query: 494 QEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADV 553
+ K N + + +G L LS + E+ H++ + KL + +
Sbjct: 2078 RLSESDYEKLNVSKALEAALVEKGEFALRLSSTQ--EEVHQLRRGIEKLR-----VRIEA 2130
Query: 554 KTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLE 602
K++ KL + ERE D LKD VENLE + ++ + E
Sbjct: 2131 DEKKQLHIAEKLKERERE--------NDSLKDKVENLERELQMSEENQE 2171
Score = 38.9 bits (89), Expect = 0.014
Identities = 76/413 (18%), Positives = 172/413 (41%), Gaps = 63/413 (15%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+KEL+ L D+V+T + +IQ K + S K L+L ++ KK +
Sbjct: 910 EKELQLLNDKVET----EQAEIQELKKSNHLLE-DSLKELQLLSETLSLEKKE------M 958
Query: 156 NAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALT 215
+++I+ E++ LT E L +++L Q L+ S+ S Y+ + E+S + L+
Sbjct: 959 SSIISLNKREIEELTQENGTLKEI--NASLNQEKMNLIQKSE-SFANYIDEREKSISELS 1015
Query: 216 LYTKKQ-------------FFQGIHEVVESSNEDNFQL--LDIQTPSICDNQE------- 253
K++ ++ + + +++ E N +L L + S+C+N++
Sbjct: 1016 DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK 1075
Query: 254 --ILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHS--------LTSK 303
+E + + +L A Q+ ++ L+ +++S + + + S + +
Sbjct: 1076 EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTL 1135
Query: 304 AVDKENLDAKISSLTSE------IMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFD 357
++ + +++ L E +MK + E ++ + V+E N K D
Sbjct: 1136 KEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMD 1195
Query: 358 LQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNM 417
L++ + + +LV + + + +L + E E +H +L+ + +L SN+
Sbjct: 1196 LEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQH-----ELQTIRGDLETSNL 1250
Query: 418 --MLYKQLEMLTDPSVSQQ----INPRNTIDTKDYSTHRLYQVLEGENKKKEL 464
M +++ L D + + P +++ + H + NK EL
Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNEL 1303
Score = 38.5 bits (88), Expect = 0.018
Identities = 59/288 (20%), Positives = 118/288 (40%), Gaps = 23/288 (7%)
Query: 287 KSSIKWAEESLHSLTSKAV----DKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRE 342
++ +K E L +L+S DK +L K+ SL + L +++++ A + +
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQI--AQLNK 2063
Query: 343 NAQLLNMPVVKGDFDLQ--IAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRD 400
+LL VK LQ +++ DY L + +K F L S + E+ + R
Sbjct: 2064 EKELL----VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 401 IYRQLENLVQELSQSNMMLYKQL---EMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEG 457
+L ++ + + + ++L E D + N + + + + +L+
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELV--ILDA 2177
Query: 458 ENKKKELFLTHGNLEEVAEKLKQ-NISLV-----QDQLAVSAQEHSFFLSKRNKDVDMLC 511
EN K E+ +EE+A LK + LV ++ L QE LS+ +K +
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237
Query: 512 DTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKT 559
L + + +E +++QL +LN + + D + + T
Sbjct: 2238 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 59.3 bits (142), Expect = 1e-08
Identities = 121/575 (21%), Positives = 227/575 (39%), Gaps = 89/575 (15%)
Query: 55 ERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTL-LKLK 113
E+E+E + KP+ EG + +K T RLD LEK E E Q L LK +
Sbjct: 52 EKEIE-----ELRSKPVTEGTG--DIIKAL------TERLDALLLEKAETEQQCLSLKKE 98
Query: 114 NLKIQRRNKCQLMASVTSHKSLRL----------NAKEEEATKKLKQSQGILNAMITKIS 163
N+K+++ + + +HK L N K E + K S+ N + K
Sbjct: 99 NIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKAN--LQKQL 156
Query: 164 NELQALTDEVTQLMMFFRHSN------------LGQGTNPLVFLSQFSLEKYLSQEEQST 211
E E+++ + F +S + G + Q L+ +++++
Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216
Query: 212 AALT--LYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSI----CDNQEILEERRLEMARL 265
L + Q +Q + + S E+ QL I + C + +E E+ +L
Sbjct: 217 TQLQNIIEANSQHYQ---KNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKL 273
Query: 266 QLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLE 325
++ + +AS +++ + E+L TS A N D +I S+ +
Sbjct: 274 NEL---KENLVKQCEASEKNIQKKYECELENLRKATSNA----NQDNQICSILLQENTFV 326
Query: 326 KEVTQIKDRSLP----------AVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELV-- 373
++V K + L +++++ +N +K + D Q K +++ R++L
Sbjct: 327 EQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFK 386
Query: 374 LNQLI--KQKASFELLQLSYEIELRKHRDIY--RQLENLVQELSQSNMMLYKQLEMLTDP 429
+N+L+ K++ + +L E+ + Y Q VQ L + + K++ L +
Sbjct: 387 INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ---KEISELNET 443
Query: 430 SVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAE-----------KL 478
+S + T+ + + L+ E K+E L + +L E+ E K+
Sbjct: 444 FLSDSEKEKLTLMFEIQGLKEQCENLQQE--KQEAILNYESLREIMEILQTELGESAGKI 501
Query: 479 KQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTL--YQGGNQLLLSDQELTEQFHKVE 536
Q ++ Q A E L + D L +T+ QG N+ LLS QEL +
Sbjct: 502 SQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTI 561
Query: 537 SQLNKLNHLLTDILADVKTKRKTLANNKLHQMERE 571
L + N + L+ T K L K++ + E
Sbjct: 562 KNLQEKNGVYLLSLSQRDTMLKEL-EGKINSLTEE 595
Score = 46.6 bits (109), Expect = 7e-05
Identities = 137/644 (21%), Positives = 259/644 (40%), Gaps = 129/644 (20%)
Query: 25 EDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTC 84
E+ D + E E L G EQ + ELE QK + L G L+E LK
Sbjct: 608 EEMDNFHKKCEREERLILELGKKVEQTIQYNSELE-----QKVNE--LTGG-LEETLKEK 659
Query: 85 KTSDLKTPRL--------DDKEL------------EKLEDEVQTLLKLKNLKIQRRNKCQ 124
+D K +L +DKE+ KL E + L + + + ++
Sbjct: 660 DQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719
Query: 125 LMASVTS-HKSLRLNAKEEEATKKLKQSQ------------GILNAMITKIS-------- 163
L +T K L+L +E++ KL +++ G L M +++S
Sbjct: 720 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779
Query: 164 -NELQALTDEVTQL------MMFFRHSNLGQGTNPLVFLSQFS------LEKYLSQEEQS 210
N LQA+ + + ++ + F R + + + L + S L+ L EQ
Sbjct: 780 VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839
Query: 211 TAALT-----LYTKKQFFQGIHEVVESSNE----DNFQLLDIQTPSI---CDNQEILEER 258
L + ++K+ Q ++++NE +N LL IQ + C EI E+
Sbjct: 840 KVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL-IQVEEVSQTCSKSEIHNEK 898
Query: 259 RLEMARLQ--LAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISS 316
+ L + Q +L +A +K S+ + + S + L+ KI +
Sbjct: 899 EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSV---KELEEKIEN 955
Query: 317 LTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQ 376
L E + E+++ +IK ++ A ++ VK + + +++D +A +
Sbjct: 956 LEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSAS----MRD 1011
Query: 377 LIKQKASFELLQLSYE-------IELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDP 429
LI+ S++ L L YE +E + + ++E+L ++L S L+ T
Sbjct: 1012 LIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST------LQCETIN 1065
Query: 430 SVSQQINPRNTIDTKDYSTHRL-YQVLEGENKK----KELFLTHGNLEEVAEKLKQNISL 484
S ++ + R I+T + L Q+LE + K KEL + +K+K++ +
Sbjct: 1066 SDNEDLLAR--IETLQSNAKLLEVQILEVQRAKAMVDKEL---EAEKLQKEQKIKEHATT 1120
Query: 485 VQD--QLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKL 542
V + +L V Q+ L K ++++++ + Q L + E+ + E + +L
Sbjct: 1121 VNELEELQVQLQKEKKQLQKTMQELELV----KKDAQQTTLMNMEIADY----ERLMKEL 1172
Query: 543 NHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDI 586
N LT+ NNK+ +E+E + K E ++I
Sbjct: 1173 NQKLTN------------KNNKIEDLEQEIKIQKQKQETLQEEI 1204
Score = 39.3 bits (90), Expect = 0.011
Identities = 110/549 (20%), Positives = 212/549 (38%), Gaps = 76/549 (13%)
Query: 20 DNLN----GEDFDWLFEGVEDESFLKWFCGNVNEQNVLSERELEAFSILQKSGKPILEGA 75
DNLN E LF + FLK V+E + E + ++LQ G+ + +
Sbjct: 739 DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDS----EEKDVVNVLQAVGESLAK-- 792
Query: 76 ALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSL 135
+E D K L+ KE++ L++E ++++ + LK R+ Q L
Sbjct: 793 INEEKCNLAFQRDEKVLELE-KEIKCLQEE--SVVQCEELKSLLRDYEQ------EKVLL 843
Query: 136 RLNAKEEEATKKLKQSQGI-LNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVF 194
R +E ++ K+ QS + + K E Q L +V ++ S +
Sbjct: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFI 903
Query: 195 LSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQT--PSICDNQ 252
+L+ L Q+E L K + +S + N L ++ I + +
Sbjct: 904 KEHENLKPLLEQKELRDRRAELILLKD------SLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 253 EILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDA 312
+ +E+ ++ +++L + A+ +L S + + +E L SL S +K+ L A
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKEL-------DSSRKETQTVKEELESLRS---EKDQLSA 1007
Query: 313 KISSLT----------------SEIMKLEKEVTQIKDRSLPAVVRE-NAQLLNMPVVKGD 355
+ L SE + +EKE + + + R+ L + D
Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSD 1067
Query: 356 FDLQIAKQDYYTARQELVLNQLIK-QKAS------FELLQLSYEIELRKHRDIYRQLENL 408
+ +A+ + + +L+ Q+++ Q+A E +L E ++++H +LE L
Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEEL 1127
Query: 409 VQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYS--THRLYQVLEGENKKKELFL 466
+L + L K ++ L Q ++ DY L Q L +N K E
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIE--- 1184
Query: 467 THGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQ 526
+LE+ + KQ +Q+++ + K K +L T + L+D
Sbjct: 1185 ---DLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKE------LADS 1235
Query: 527 ELTEQFHKV 535
+ E H +
Sbjct: 1236 KQAETDHLI 1244
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 57.4 bits (137), Expect = 4e-08
Identities = 81/406 (19%), Positives = 168/406 (41%), Gaps = 71/406 (17%)
Query: 99 LEKLEDEVQTLLKLKNLKIQRRNKCQLMAS------------VTSHKSLRLNAKEEEATK 146
L+ LE E++T+ N +Q RN Q S +T+H S + E A K
Sbjct: 837 LQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEI--EMAQK 894
Query: 147 KLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQ 206
K+ + +S++ L +E+ L + + K +Q
Sbjct: 895 KMNSENSHSHEEEKDLSHKNSMLQEEIAMLRL------------------EIDTIKNQNQ 936
Query: 207 EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQ 266
E++ K+ F+ + ++V+ NED +I N+E L + + +
Sbjct: 937 EKE----------KKCFEDL-KIVKEKNED-------LQKTIKQNEETLTQT-ISQYNGR 977
Query: 267 LAYICAQHQLIHLKASNSSMKSSIKWAE-ESLHSLTSKAV-DKENLDAKISSLTSEIMKL 324
L+ + A++ +++ K N AE ES HS + A+ D++ + L +
Sbjct: 978 LSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRA 1037
Query: 325 EKEVTQIKDRSLPAV--VRENAQLLNMPVVKGDFDLQIAKQDYYTARQEL---------V 373
E ++++D+ V +++N ++L+ + K + L + +++ R L V
Sbjct: 1038 RDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERV 1097
Query: 374 LNQLIKQKASFELLQLSYE---IELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPS 430
L + + + ++ Y+ +++ K+ +E + +L NM+L +QL D +
Sbjct: 1098 QKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQL----DDA 1153
Query: 431 VSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAE 476
++ N T+ H + Q L+ E++K+ L L N E ++E
Sbjct: 1154 HNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISE 1199
Score = 37.7 bits (86), Expect = 0.031
Identities = 109/533 (20%), Positives = 211/533 (39%), Gaps = 110/533 (20%)
Query: 97 KELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILN 156
+E+ L E+ T+ KN ++ KC + K+ E+ K +KQ++ L
Sbjct: 919 EEIAMLRLEIDTI---KNQNQEKEKKCFEDLKIVKEKN-------EDLQKTIKQNEETLT 968
Query: 157 AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLS----------Q 206
I++ + L LT E M+ + N Q L + +E Y S Q
Sbjct: 969 QTISQYNGRLSVLTAE--NAMLNSKLENEKQSKERL----EAEVESYHSRLAAAIHDRDQ 1022
Query: 207 EEQSTAALTLYTKK-----QFFQGIHEVVESSNEDNFQLLDIQ---TPSICDNQEI---- 254
E S L L ++ Q S+ +DN ++L Q T S ++ EI
Sbjct: 1023 SETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHH 1082
Query: 255 ----LEERRLEMARLQ--LAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDK- 307
L E+ L + R+Q L+ Q + + K N +K +K + K
Sbjct: 1083 TRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVK-------------VNKYIGKQ 1129
Query: 308 ENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYT 367
E+++ ++S L SE M L +++ +++ + ++N ++ F + K +
Sbjct: 1130 ESVEERLSQLQSENMLLRQQLDDAHNKA----DNKEKTVIN---IQDQFHAIVQKLQAES 1182
Query: 368 ARQELVLNQ----LIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQL 423
+Q L+L + LI + + Q YE E + + RQL+ + + + M L
Sbjct: 1183 EKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASL 1242
Query: 424 EMLTDPSVSQQINP----------RNTI-DTKDYSTHRLYQVLEGENKKKELFLTHGNLE 472
E+ + ++ + RN + + +D T + + ++ K++L + L+
Sbjct: 1243 EVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLK 1302
Query: 473 EVAEKLKQNISLVQDQL--AVSAQEHSFFLSKR---------NKDVDMLCDTLYQGG--- 518
+K I +Q L A +++ L K N D +M + +
Sbjct: 1303 VTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITG 1362
Query: 519 --NQLLLSDQELTE------QFH--------KVESQLNKLNHLLTDILADVKT 555
N L ++ ++L E FH +++ Q+NKL H + D+ A+++T
Sbjct: 1363 FKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELET 1415
Score = 30.0 bits (66), Expect = 6.4
Identities = 38/216 (17%), Positives = 88/216 (40%), Gaps = 32/216 (14%)
Query: 308 ENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYT 367
E L KI + ++ L++E+++ K+ +K + Q + +
Sbjct: 747 ELLTVKIKKMEDKVNVLQRELSETKE------------------IKSQLEHQKVEWEREL 788
Query: 368 ARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLT 427
LNQ +++ + + L +LR+ + YR+ + Q+L S L +L +
Sbjct: 789 CSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVK 848
Query: 428 DPSVSQQINPRNTIDTK------------DYSTHRLYQVLEGENKKKELFLTHGNLEEVA 475
+++Q + RN + T+ L + E E +K++ + + E
Sbjct: 849 S-NLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEE 907
Query: 476 EKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLC 511
+ L S++Q+++A+ E + +N++ + C
Sbjct: 908 KDLSHKNSMLQEEIAMLRLEID-TIKNQNQEKEKKC 942
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 56.6 bits (135), Expect = 6e-08
Identities = 100/555 (18%), Positives = 234/555 (42%), Gaps = 74/555 (13%)
Query: 43 FCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPR---LDDKEL 99
FC N ++ ++ + ++ K KP+L+ A ++ + T K +T +
Sbjct: 816 FCIQYNIRSFMNVKHWPWMNLFFKI-KPLLKSAEAEKEMATMKEDFERTKEELARSEARR 874
Query: 100 EKLEDEVQTLLKLKN-LKIQRRNKCQLMASVTSH------KSLRLNAKEEEATKKLKQSQ 152
++LE+++ +LL+ KN L++Q +++ + + + L AK +E T++L++ +
Sbjct: 875 KELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEE 934
Query: 153 GILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTA 212
+ + ++ K N L D+ + L L L++ EK+ ++ +
Sbjct: 935 EMNSELVAKKRN----LEDKCSSLKRDIDDLELT--------LTKVEKEKHATENKVKNL 982
Query: 213 ALTLYTKKQFFQGIHEVVESSNEDNFQLLD-IQTPSICDNQEILEERRLEMARLQLAYIC 271
+ + ++ + + +S E + Q LD +Q N I +LE L
Sbjct: 983 SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 272 AQHQLIH--LKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT 329
Q + + L+ + ++ +K ++ES+ L + DK+ ++ K+ E+ +L+ ++
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLEN---DKQQIEEKLKKKEFELSQLQAKI- 1098
Query: 330 QIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQL 389
++ Q+ ++ K +LQ ++ +E+ ++ K
Sbjct: 1099 ------------DDEQVHSLQFQKKIKELQARIEEL---EEEIEAEHTLRAKIE------ 1137
Query: 390 SYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTID-TKDYST 448
++ D+ R+LE + + L +++ Q+EM Q R+ + T +
Sbjct: 1138 ------KQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 449 HRLYQVLEGENKKKELFLTHGNLEEVAEKL---KQNISLVQDQLAVSAQEHSFFLSKRNK 505
+ + EL NL+ V +KL K + + D +A + + LSK
Sbjct: 1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEA----LSKSKS 1247
Query: 506 DVDMLCDTLYQGGNQLLLSDQELTEQFH-------KVESQLNKLNHLL--TDILADVKTK 556
+++ C T+ +++ D++ T+ H ++++Q +L+H + + L TK
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307
Query: 557 RKTLANNKLHQMERE 571
K +L +++R+
Sbjct: 1308 SKQALTQQLEELKRQ 1322
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 56.6 bits (135), Expect = 6e-08
Identities = 104/521 (19%), Positives = 216/521 (41%), Gaps = 92/521 (17%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+K LED+ L +K + + +L+ +++ K+ RL+ + E +++L +
Sbjct: 1250 EKMCRTLEDQ------LSEIKTKEEEQQRLINELSAQKA-RLHTESGEFSRQLDEK---- 1298
Query: 156 NAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQ--STAA 213
+AM++++S QA T ++ +L ++ L +E + ST A
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEEL------------------------KRQLEEETKAKSTLA 1334
Query: 214 LTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYIC-A 272
L + + + E E E +L Q + + E+A+ + Y A
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAEL-----------QRGMSKANSEVAQWRTKYETDA 1383
Query: 273 QHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIK 332
+ L+ + + ++ AEE + ++ SK +SL +L+ EV +
Sbjct: 1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNSKC----------ASLEKTKQRLQNEVEDL- 1432
Query: 333 DRSLPAVVRENAQLLNMPVVKGDFDLQIA--KQDYYTARQELVLNQLIKQKASFELLQL- 389
+ V R NA + + + +FD +A KQ Y + EL +Q + S EL ++
Sbjct: 1433 ---MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK 1489
Query: 390 -SYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTD-PSVSQQINPRNTIDTKDYS 447
+YE L + R+ +NL QE+S + + + + + V +Q+ D+
Sbjct: 1490 NAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQL---------DHE 1540
Query: 448 THRLYQVLEGENKKKELFLTH--GNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNK 505
L LE + E L H G + + +L Q S + ++A +E +
Sbjct: 1541 KSELQTSLE----EAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLR 1596
Query: 506 DVDMLCDTL---YQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLAN 562
V+ + TL + N L +++ +++E QLN N + L +++ + L +
Sbjct: 1597 VVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKD 1656
Query: 563 NKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED 603
+LH + ++ +D LK+ + +E ++ + +E+
Sbjct: 1657 TQLHLDDA------IRGQDDLKEQLAMVERRANLMQAEVEE 1691
Score = 44.3 bits (103), Expect = 3e-04
Identities = 91/499 (18%), Positives = 208/499 (41%), Gaps = 78/499 (15%)
Query: 69 KPILEGAALDEALKTCKTSDLKTPR---LDDKELEKLEDEVQTLLKLKN-LKIQRRNKCQ 124
KP+L+ A ++ + K KT + + ++LE+++ TL++ KN L++Q + +
Sbjct: 841 KPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEAD 900
Query: 125 LMASVTSH------KSLRLNAKEEEATKKLKQSQGI---LNAMITKISNELQALTDEVTQ 175
+A ++L AK +E T++ + + I L A K+ +E L ++
Sbjct: 901 ALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 960
Query: 176 LMMFF------RHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEV 229
L + +H+ + N L + ++ +++ A LT +K+ Q H+
Sbjct: 961 LELTLAKVEKEKHATENKVKN---------LTEEMAGLDETIAKLT--KEKKALQEAHQ- 1008
Query: 230 VESSNEDNFQLLDIQTPSICDNQEILEER--RLEMARLQLAYICAQHQLIHLKASNSSMK 287
D+ Q+ + + ++ + LE++ LE + Q +C + L+ + ++
Sbjct: 1009 ---QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC-----MDLERAKRKLE 1060
Query: 288 SSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLL 347
+K A+ES + DK+ L+ K+ E+ L+ ++ E+ Q L
Sbjct: 1061 GDLKLAQESTMDTEN---DKQQLNEKLKKKEFEMSNLQGKI-------------EDEQAL 1104
Query: 348 NMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLEN 407
+ + K +LQ AR E + ++ ++AS + ++ D+ R+LE
Sbjct: 1105 AIQLQKKIKELQ--------ARIEELEEEIEAERASRAKAE-------KQRSDLSRELEE 1149
Query: 408 LVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLT 467
+ + L ++ Q+EM Q R D ++ + K +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRR---DLEESTLQHEATAAALRKKHADSVAE 1206
Query: 468 HGNLEEVAEKLKQNISLVQDQLAVSAQE---HSFFLSKRNKDVDMLCDTLYQGGNQLLLS 524
G + +++KQ + + +L + + + +SK + + +C TL +++
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTK 1266
Query: 525 DQELTEQFHKVESQLNKLN 543
++E +++ +Q +L+
Sbjct: 1267 EEEQQRLINELSAQKARLH 1285
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 161/404 (39%), Gaps = 51/404 (12%)
Query: 48 NEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQ 107
+E+ + +LE + + + I E DE L K + L+ +E ++ +
Sbjct: 1557 HEEGKILRIQLELNQVKSEIDRKIAEK---DEELDQLKRNHLRV-------VESMQSTLD 1606
Query: 108 TLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQ 167
++ +N ++ + K + + + N + EA + L+ +QGIL + + ++
Sbjct: 1607 AEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIR 1666
Query: 168 ALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIH 227
D QL M R +NL Q V + SLE+ ++ + A L + Q +H
Sbjct: 1667 GQDDLKEQLAMVERRANLMQAE---VEELRASLER--TERGRKMAEQELLDASERVQLLH 1721
Query: 228 ----EVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKA-- 281
++ + + + IQ + ++I++E R + + A A LK
Sbjct: 1722 TQNTSLINTKKKLETDISQIQG----EMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 282 -SNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVV 340
+++ ++ K E+++ L + + E L K +I KLE V +++
Sbjct: 1778 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK--KQIQKLEARVRELESEV----- 1830
Query: 341 RENAQLLNMPVVKG--DFDLQIAKQDYYTAR--------QELVLNQLIKQKA---SFELL 387
E+ Q N+ VKG + ++ + Y T Q+LV K KA E
Sbjct: 1831 -ESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEA 1889
Query: 388 QLSYEIELRKHRDIYRQLENLVQEL----SQSNMMLYKQLEMLT 427
+ + L K R + +LE + SQ N + K E+ T
Sbjct: 1890 EEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHT 1933
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 55.8 bits (133), Expect = 1e-07
Identities = 105/499 (21%), Positives = 207/499 (41%), Gaps = 65/499 (13%)
Query: 97 KELEKLEDEVQTLLKL--KNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGI 154
KE +LE ++TL + + +KI + L +V+S + R E K +++ I
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAEARVKDIEKENKI 591
Query: 155 LNAMITKISNELQALTDEVTQLMMFFRH-SNLGQGTNPLVF-LSQFSLEKYLSQEEQSTA 212
L+ I + S++L + E Q+ H G+ L L E L Q++ +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 213 ALTLYTKKQFFQGIHEVVESSNE-----DNFQLLDIQTPSICDNQEILEERRLEMARLQL 267
+T + Q E+ + + D+F+ L Q S+ L+E LE+ R
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 268 AYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEK- 326
+ CA ++ L+ N ++S + ++ L L + E L+ L E +L+K
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 327 -EVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFE 385
E + K + L + + ++ ++ N + K +L+I+ + L QL K+ S E
Sbjct: 772 LENSNKKIQQLESEL-QDLEMENQTLQKNLEELKISSKR---------LEQLEKENKSLE 821
Query: 386 LLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQ------QINPRN 439
QLE ++L + N L +Q E + D ++ + + N
Sbjct: 822 --------------QETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEENNVKIGNLEKEN 866
Query: 440 TIDTKDYSTHR--LYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHS 497
+K+ ++ ++ E E + KEL ++ +K ++L +D ++ +
Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKEL------VKRATIDIKTLVTLREDLVSEKLK--- 917
Query: 498 FFLSKRNKDVDMLCDTLYQGG--NQLLLSDQELTEQFH-----KVESQLNKLNHLLTDIL 550
+ N D++ L L + G + LL D++ T+ + K+ES L K + + +
Sbjct: 918 --TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
Query: 551 A--DVKTKRKTLANNKLHQ 567
A + + + T N +L Q
Sbjct: 976 AALEARLEESTNYNQQLRQ 994
Score = 48.5 bits (114), Expect = 2e-05
Identities = 115/575 (20%), Positives = 228/575 (39%), Gaps = 136/575 (23%)
Query: 64 LQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEV----QTLLKLKNLKIQR 119
L+K K + + A + + T + +++K L+ KE + L E+ ++ ++LK L ++
Sbjct: 834 LEKENKRLRQQAEIKDT--TLEENNVKIGNLE-KENKTLSKEIGIYKESCVRLKEL--EK 888
Query: 120 RNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMF 179
NK +L+ T + +E+ ++KLK Q ++N+L+ LT E+ ++
Sbjct: 889 ENK-ELVKRATIDIKTLVTLREDLVSEKLKTQQ---------MNNDLEKLTHELEKI--- 935
Query: 180 FRHSNLGQGTNPLVFLSQFSLEKY--LSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDN 237
G L+ Q + ++Y L + +ST +L K++ + +E S N
Sbjct: 936 ------GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 989
Query: 238 FQLLDIQTPSICDNQEILEERRLEMARLQLA--------------------YICAQHQLI 277
QL + ++ N E L++R+ E +Q + + + +LI
Sbjct: 990 QQLRQ-ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 278 HLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT-------- 329
++ +N+++++ + + L L ++ NL A+I +L + + L+++ T
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQ---NNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
Query: 330 -QIKDRSL----PAVVRENAQLL---------NMPVVKGDFDLQIAKQDYYTARQELVL- 374
Q+++ +L +++ +NAQLL N V+K DL+ ++L L
Sbjct: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1165
Query: 375 ------------------------------------NQLIKQKASFELLQLSYEIELRK- 397
NQL+KQK E L+ ++E K
Sbjct: 1166 HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1225
Query: 398 ------HRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRL 451
H + + + L E + N Y QL T+ + N ++ ++ RL
Sbjct: 1226 LLENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1284
Query: 452 YQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLC 511
E + +L + L+ + KL L+ +E+ L +
Sbjct: 1285 ------EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ--------I 1330
Query: 512 DTLYQGGNQLLLSDQELTEQFHKVESQ-LNKLNHL 545
TL LL + E + FH + Q ++KLN L
Sbjct: 1331 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Score = 44.3 bits (103), Expect = 3e-04
Identities = 122/578 (21%), Positives = 233/578 (40%), Gaps = 100/578 (17%)
Query: 48 NEQNVLSERELEAFSILQKSGKPILEGAAL------DEALKTCKT-SDLKTPRLDDKELE 100
N++NV + +E + Q+ +P+L+ AL DE + +T +L R L
Sbjct: 166 NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 225
Query: 101 KLEDEVQTLLKLKNLK-IQRRNKCQLMASVTSHKSLRLNAKEEEATKKL---KQSQGILN 156
Q+ +K + R + + K RL + EE T++L KQ +
Sbjct: 226 HASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQME 285
Query: 157 AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTL 216
+ ++ E L + M+ L V + + LE +S+ ++ +
Sbjct: 286 IELKRLQQENMNLLSDARSARMY--RDELDALREKAVRVDK--LESEVSRYKERLHDIEF 341
Query: 217 YTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQL 276
Y + VE EDN LL+ +T + E +LE R + +L
Sbjct: 342 YKAR---------VEELKEDNQVLLETKT---------MLEDQLEGTRAR------SDKL 377
Query: 277 IHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSL 336
L+ N +K+ LH + ++++ KI L E M LE Q D SL
Sbjct: 378 HELEKENLQLKA-------KLHDM---EMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 337 P-----AVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSY 391
+ ++L P ++ EL ++L+K + + L +
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEV-----------NELTSSRLLKLEMENQSLTKTV 476
Query: 392 EIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTID-TKDYSTHR 450
E ELR D + + ++ + N L K++E+L + V ++ + +N + +KD +
Sbjct: 477 E-ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 451 --LYQVLE--GENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKD 506
L + +E EN ++++ + LE+ E L Q +S ++ + +SA+ R KD
Sbjct: 536 AQLEKTIETLRENSERQIKI----LEQENEHLNQTVSSLRQRSQISAE-------ARVKD 584
Query: 507 VDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLH 566
++ L++ S +E + + K+E + ++ L K +R N+LH
Sbjct: 585 IEKENKILHE-------SIKETSSKLSKIEFEKRQIKKELEHY--KEKGERAEELENELH 635
Query: 567 QMEREFYVYFLKDEDYLKDIVENLE-TQSKIKAVSLED 603
+E K+ + L+ + NL+ T KI+A+ E+
Sbjct: 636 HLE--------KENELLQKKITNLKITCEKIEALEQEN 665
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 55.8 bits (133), Expect = 1e-07
Identities = 115/553 (20%), Positives = 230/553 (41%), Gaps = 78/553 (14%)
Query: 79 EALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLN 138
+ L+ K + L D EL+ L++EV T + L N +IQ ++ VT K
Sbjct: 1864 QTLENEKNTLLSQISTKDGELKMLQEEV-TKMNLLNQQIQEE-----LSRVTKLKETAEE 1917
Query: 139 AKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQF 198
K++ + + Q L + I N Q +TD Q N L+
Sbjct: 1918 EKDDLEERLMNQ----LAELNGSIGNYCQDVTD--------------AQIKNELLESEMK 1959
Query: 199 SLEKYLSQ-EEQSTAALTLYTK------KQFFQGIHEVV-ESSNEDNFQLLDIQTPSICD 250
+L+K +S+ EE+ + TK K++ + I E N+ + + L
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL--------- 2010
Query: 251 NQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMK----SSIKWAEESLHSLTSKAVD 306
QE+L+E++ E+ +LQ I Q ++ L+ + +++ S K E + +L
Sbjct: 2011 -QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 307 KENLDAKISSLTSEIMKLEKEVTQI--KDRSLPAVVRENAQLLNMPVVKGDFDLQI---- 360
++ A+++S + + E ++ + L ++ N + + + + D DL+
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Query: 361 AKQDYYTARQELV--LNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMM 418
A++ + ++ + L+ L ++K E ++ L K + VQ+L ++
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK-------DKEVQQLQENLDS 2182
Query: 419 LYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKL 478
QL T S Q + ID + ++ +K++E+ L N + ++L
Sbjct: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ--SKEEEIRLKEDNCSVLKDQL 2240
Query: 479 KQ-NISLVQDQLAVSAQEHS--FFLSKRNKDVDM---LCDTLYQGGNQLLLSDQELTEQF 532
+Q +I + + ++ +S EH + SK +V + +CDTL +LL +E +
Sbjct: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300
Query: 533 H-------KVESQLNKLNHLLTDILADVKTKRKTLANNK--LHQMEREFYVYFLKDEDYL 583
H K+ES+L L LTD+ ++ ++ N + + Q E + E
Sbjct: 2301 HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360
Query: 584 KDIVENLETQSKI 596
D+ + E S++
Sbjct: 2361 TDLQASRELTSRL 2373
Score = 42.0 bits (97), Expect = 0.002
Identities = 118/615 (19%), Positives = 246/615 (40%), Gaps = 129/615 (20%)
Query: 53 LSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKL 112
++ER+L +F LQ+ +LE ++A + + + L+ K ++E++ +L L
Sbjct: 328 VAERKL-SFHNLQEEMHHLLE--QFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL 384
Query: 113 KNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDE 172
+ + ++ C ++ S L K E+A + + Q ++ ++LQ + E
Sbjct: 385 QKTGQELQSACD---ALKDQNSKLLQDKNEQAVQSAQTIQ--------QLEDQLQQKSKE 433
Query: 173 VTQLMMFF---RHSNLGQ---------GTNPLVFLSQFSLEKYLSQEEQSTAALTLYT-- 218
++Q + +H Q GT + + SL+K + + E AL L +
Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 219 ------KKQFFQGIHEVVESSNEDNFQLLDIQTPSICD------------NQEILE---- 256
+ + ++E+ N ++ SI D Q++LE
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 257 ERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSK------------- 303
++ E++ L L AQ ++ LK ++ K AEE+ H + +
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLK-----LQLQGKRAEEADHEVLDQKEMKQMEGEGIAP 608
Query: 304 -------------------------AVDKENLDAKISSLTSEIMKLEKEVTQIK------ 332
AV+KE + S TSE + L ++K
Sbjct: 609 IKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDG 668
Query: 333 DRSLPAVV------RENAQLLNMPVVKGDFDLQIAKQDYYT-----ARQELVLNQLIKQK 381
D+SL AV ++ + L +++ + + A++ Y A++ LNQLI++
Sbjct: 669 DKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF 728
Query: 382 ASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMML--YKQLEM-LTDPSVSQQINPR 438
S L + RD QL + V+ELS + KQLEM L + ++++
Sbjct: 729 KKNADNNSSAFTALSEERD---QLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYE 785
Query: 439 NTIDTKDYSTHRLYQV-LEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHS 497
+ + T +++ + +E ++K ++ + L++V + + +L++ S
Sbjct: 786 SQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIR----------S 835
Query: 498 FFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKR 557
+NK+ ++L + + +EL++ + E ++ K++ LL + DV+T +
Sbjct: 836 LQSQLQNKESEVLEGA--ERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQ 893
Query: 558 KTLANNKLHQMEREF 572
+T+ E F
Sbjct: 894 QTIEEKDQQVTEISF 908
Score = 42.0 bits (97), Expect = 0.002
Identities = 122/596 (20%), Positives = 234/596 (39%), Gaps = 105/596 (17%)
Query: 48 NEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQ 107
N+ ++L E +I+QK + + D +T + P E K E E +
Sbjct: 1106 NQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELE-E 1164
Query: 108 TLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEA-----TKKLKQSQGILNAMITKI 162
+L L+ K Q + K Q ++TS K++ A+E+E K+ K L +
Sbjct: 1165 KILALEKEKEQLQKKLQ--EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222
Query: 163 SNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQF 222
S E + + D++ QL + R S G K S ++Q + + T
Sbjct: 1223 SKENENIGDQLRQLQIQVRESIDG---------------KLPSTDQQESCSST------- 1260
Query: 223 FQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKAS 282
G+ E + + E + Q +LE +C AS
Sbjct: 1261 -PGLEEPLFKATEQHH------------TQPVLESN-----------LCPDWPSHSEDAS 1296
Query: 283 NSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDR-------- 334
+S+ + L + ++ V+ L+ K+SS TSE+ K +EV Q++++
Sbjct: 1297 ALQGGTSVAQIKAQLKEIEAEKVE---LELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
Query: 335 -SLPAVVRE---NAQLLNMPVVKGDFDLQIAKQDYYTARQELV--LNQLIKQK---ASFE 385
SL V E +A+ L + LQIA ++ Q + L +LI +K S+
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLESS--QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYL 1411
Query: 386 LLQLS--------YEIELRKHRDIYRQLENLVQELSQSNMMLYKQL-----EMLTDP-SV 431
QLS + E+ + D+ + L ++ ++ + KQL EM P +
Sbjct: 1412 SGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEI 1471
Query: 432 SQQINPRNTIDTKDYST--HRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQ- 488
++ + I K + R + E ++ ++EL L G +E + + L S V Q
Sbjct: 1472 GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQN 1531
Query: 489 ---------LAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQL 539
LA+ +E +++ ++ + + +L L L+ + LTE K+ ++
Sbjct: 1532 KEKDTVLGRLALLQEERDKLITEMDRSL-LENQSLSSSCESLKLALEGLTEDKEKLVKEI 1590
Query: 540 NKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSK 595
L + + K K L K +++ + Y + + ++ +VE + + +
Sbjct: 1591 ESLKSSKIAESTEWQEKHKEL--QKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ 1644
Score = 39.3 bits (90), Expect = 0.011
Identities = 118/594 (19%), Positives = 244/594 (41%), Gaps = 100/594 (16%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTL 109
+N S++ E +L + + E A L L+ + + LD KE++++E E
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAP 608
Query: 110 LKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATK----------------KLKQSQG 153
+K+K LM + S SL KE+ +T+ +LK ++
Sbjct: 609 IKMKVFLEDTGQDFPLMPNEES--SLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQ 666
Query: 154 ILNAMITKI-------SNELQALTDEVTQLMMFFR------HSNLGQGTNPLVFLSQFSL 200
+ ++ + +EL+ L ++ +L + F NL + + L+Q +
Sbjct: 667 DGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQL-I 725
Query: 201 EKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRL 260
E++ + +++A T + +E+ QLL S ++ E R
Sbjct: 726 EEFKKNADNNSSAFT----------------ALSEERDQLL-----SQVKELSMVTELRA 764
Query: 261 EMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSE 320
++ +L++ A+ Q + S + E +HSL+ +A K D KI E
Sbjct: 765 QVKQLEMNLAEAERQ---RRLDYESQTAHDNLLTEQIHSLSIEAKSK---DVKI-----E 813
Query: 321 IMKLEKEVTQIKDRSLPAVVRE-NAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIK 379
+++ E + Q++ ++R +QL N K L+ A++ + + + L+Q +
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQN----KESEVLEGAERVRHISSKVEELSQALS 869
Query: 380 QKASFELLQLSYEIELRKHRDI---YRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQIN 436
QK E+ ++ ++ L K RD+ + +E Q++++ + + +++ L + S +
Sbjct: 870 QK-ELEITKMD-QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVE 927
Query: 437 PRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQE- 495
I T + L + E + ++ E EV+ LKQN + +S +E
Sbjct: 928 ----IKTLKEQLNLLSRAEEAKKEQVE------EDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 496 -HSFFLSKRNKDVDMLCDTLYQGGNQL---LLSDQELTEQFHKVESQLNKLNHLLTDILA 551
H F L K+ + Q +L L++ +EL ++ ++E +L L +
Sbjct: 978 QHEFDLLKKENE---------QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 552 DVKTKRKTLANNKLHQMEREFYV--YFLKDEDYLKDIVENLETQSKIKAVSLED 603
+T+R + +K ++ E V + E YLK + E + + LE+
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1082
Score = 38.5 bits (88), Expect = 0.018
Identities = 125/603 (20%), Positives = 235/603 (38%), Gaps = 79/603 (13%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDL-KTPRLDD--KELEKLEDEV 106
+N+LS+ E E + +++ K + + L E LKT K ++ + +LD K + L+++
Sbjct: 2414 ENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473
Query: 107 QTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNEL 166
++ +R L ++ N K +E + L+ LN+ K+ EL
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533
Query: 167 QALTDEVTQLMMFFRHSNLGQ------GTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKK 220
+++ Q++ + S Q N + LE+ L + E++ L +
Sbjct: 2534 IQYREDLNQVIT-IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDL-----R 2587
Query: 221 QFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEIL-EERRLEMARLQLAYICAQHQLIHL 279
+ F + E + +++ + L + + L EE L + QL + ++ L
Sbjct: 2588 RSFNALQEEKQDLSKE-IESLKVSISQLTRQVTALQEEGTLGLYHAQLK--VKEEEVHRL 2644
Query: 280 KASNSSMKSSIKWAEESLHSLTSKAVDK-----ENLDAKISSLTSE--IMKLEKEVTQIK 332
A SS + I EE L + +A K + L ++ L + IM+ E E + +
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER 2704
Query: 333 DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQEL------VLNQLIKQKASF-- 384
L + E Q L M V K + L Q + + L +L + K +
Sbjct: 2705 VAELARDLVEMEQKLLM-VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDA 2763
Query: 385 ---ELLQLSYEIELRKHRD---------IYRQLENLVQELSQSNMMLYKQLEMLTDPSVS 432
EL QL + L + RD + EN + L + N L + E L S S
Sbjct: 2764 SLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS-S 2822
Query: 433 QQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEV--AEKLKQNISLVQDQLA 490
Q + N + + + L +N++ L+ LE+ +E+ KQ +
Sbjct: 2823 QLEDSYNQVQSFSKAMASL------QNERDHLW---NELEKFRKSEEGKQRSAAQPSTSP 2873
Query: 491 VSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLT--D 548
Q +S D D L L Q L +QE+TE H +++QL +
Sbjct: 2874 AEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE-LHPLKAQLQEYQDKTKAFQ 2932
Query: 549 ILADVKTKRKTLANNKLHQME-------------REFYVYFLKDED----YLKDIVENLE 591
I+ + + ++LHQ+ +E Y+ + D+D +L++++ L
Sbjct: 2933 IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELR 2992
Query: 592 TQS 594
+ S
Sbjct: 2993 SSS 2995
Score = 36.6 bits (83), Expect = 0.068
Identities = 97/529 (18%), Positives = 213/529 (40%), Gaps = 67/529 (12%)
Query: 100 EKLEDEVQTLLKLKNLKIQRRNKC---QLMASVTSHKSLRLNAKEEEATKKLKQSQGILN 156
E+L E++ +++ K++++Q++++ + A+ K L+L+AK KL +
Sbjct: 58 EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA-----KLTSLNKYIE 112
Query: 157 AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQ-EEQSTAALT 215
M + L QL + S + +EK + +E+ T
Sbjct: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTE----------EEMEIEKIKHKLQEKEELIST 162
Query: 216 LYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQ 275
L + Q S+ + F ++ Q + + +E + + ++++ Q A Q
Sbjct: 163 LQAQLTQAQAEQPAQSSTEMEEFVMMKQQ---LQEKEEFISTLQAQLSQTQAEQ--AAQQ 217
Query: 276 LIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEK------EVT 329
++ K ++ ++ ++ E+ L L ++A + + K+ L ++ + E+ +V
Sbjct: 218 VVREK--DARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275
Query: 330 QIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQ- 388
+ + L A + N Q+L+ + + + + + T R+E ++++ +K E+ +
Sbjct: 276 DLLQQELTAAEQRN-QILSQQLQQMEAEHNTLRNTVETEREE---SKILLEKMELEVAER 331
Query: 389 -LSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYS 447
LS+ + + Q E Q ++ Y LE + ++ + ++
Sbjct: 332 KLSFHNLQEEMHHLLEQFEQAGQAQAELESR-YSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 448 THRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSK----- 502
L+ +N K L N E A + Q I ++DQL ++E S FL++
Sbjct: 391 LQSACDALKDQNSK---LLQDKN--EQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
Query: 503 RNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDI-LADVKTKRKTL- 560
+Y G Q + + + Q VE + K LL+ I L ++K + + L
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLS 505
Query: 561 -------ANNKLHQMEREFYVYFLKD---------EDYLKDIVENLETQ 593
A N+ + +RE + D E+ +D++EN +Q
Sbjct: 506 SQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQ 554
Score = 35.4 bits (80), Expect = 0.15
Identities = 91/532 (17%), Positives = 207/532 (38%), Gaps = 88/532 (16%)
Query: 97 KELEKLEDEVQTLLKL--KNLK--IQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQ 152
K LE ++ E Q L++ +NL ++ R K Q A + S K L L+ + EA + L +
Sbjct: 2043 KALEFVQTESQKDLEITKENLAQAVEHRKKAQ--AELASFKVL-LDDTQSEAARVLADNL 2099
Query: 153 GI---LNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQ 209
+ L + + ++++ +++ + + +L + N L EK +E
Sbjct: 2100 KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETI 2159
Query: 210 STAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAY 269
+TL K + Q + E ++S+ + D +++E + + A
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDA- 2218
Query: 270 ICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEV- 328
I ++ + I LK N S+ L ++ E L IS L + E +
Sbjct: 2219 IQSKEEEIRLKEDNCSVLKD---------QLRQMSIHMEELKINISRLEHDKQIWESKAQ 2269
Query: 329 --TQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELV------------- 373
Q++ + + EN +LL+ L+ + Y++++ EL
Sbjct: 2270 TEVQLQQKVCDTLQGENKELLSQ--------LEETRHLYHSSQNELAKLESELKSLKDQL 2321
Query: 374 ------LNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLT 427
L + +QK + E + E +++ + Y QLE +Q + L++++ M
Sbjct: 2322 TDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM-- 2379
Query: 428 DPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQD 487
++ +L G+ + ++ + E+ ++ + I +++
Sbjct: 2380 -------------------KEQKIISLLSGKEEAIQVAIA-----ELRQQHDKEIKELEN 2415
Query: 488 QLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLT 547
L+ +E+ + K VD NQL+ + + + ++ + ++QL+
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKT--------NQLMETLKTIKKENIQQKAQLDS----FV 2463
Query: 548 DILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAV 599
++ ++ R + + ER + KD+ + EN + + +I+ +
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGL 2515
Score = 31.6 bits (70), Expect = 2.2
Identities = 73/393 (18%), Positives = 159/393 (40%), Gaps = 46/393 (11%)
Query: 45 GNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLED 104
G + Q + E E+ S L S + + A L+E L C + K++ ++ED
Sbjct: 2628 GLYHAQLKVKEEEVHRLSALFSSSQKRI--AELEEEL-VCVQKEAA------KKVGEIED 2678
Query: 105 EVQTLLK-LKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGI------LNA 157
+++ LK L + RN+ + + + L E++ K+++G+
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGR 2738
Query: 158 MITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLY 217
++ + N +E+ +L + S L L+Q + L++E + + T +
Sbjct: 2739 SMSSLQNSRDHANEELDELKRKYDAS--------LKELAQLKEQGLLNRERDALLSETAF 2790
Query: 218 TKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLI 277
+ + +E N+ QLL + + LE+ ++ A Q++
Sbjct: 2791 SMNSTEENSLSHLEKLNQ---QLLS-KDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERD 2846
Query: 278 HLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLP 337
HL + S + + S ++ + ++L +SSL ++ +L KE+ ++ + L
Sbjct: 2847 HLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL- 2905
Query: 338 AVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELV----------LNQLIKQKASFEL- 386
+ N ++ + +K K + QE + L+QL +K+S+E+
Sbjct: 2906 ---QINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIH 2962
Query: 387 ---LQLSYEIELRKHRDIYRQLENLVQELSQSN 416
++ Y + + L+NL++EL S+
Sbjct: 2963 ERRMKEQYLMAISDKDQQLSHLQNLIRELRSSS 2995
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 55.1 bits (131), Expect = 2e-07
Identities = 115/549 (20%), Positives = 218/549 (39%), Gaps = 79/549 (14%)
Query: 69 KPILEGAALDEALKTCKTSDLKTPRLDDK---ELEKLEDEVQTLLKLKN-LKIQRRNKCQ 124
KP+L+ +E L+ LK K ELE++E + Q LL+ KN L Q + + +
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 125 LMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSN 184
L A ++ RL AK++E + L L + + + Q L +E ++ +
Sbjct: 902 LFAEAEEMRA-RLAAKKQELEEILHD----LESRVEEEEERNQILQNEKKKMQAHIQ--- 953
Query: 185 LGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQ 244
LE+ L +EE + K Q + E E+ LL+ Q
Sbjct: 954 --------------DLEEQLDEEEGAR------QKLQLEKVTAEAKIKKMEEEILLLEDQ 993
Query: 245 TPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIK---WAEESLHSLT 301
++++E+R E + L ++ M S ++ EE
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 302 SKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQ-- 359
KA K LD + + L +I +L+ ++ ++K + + K + +LQ
Sbjct: 1054 EKA--KRKLDGETTDLQDQIAELQAQIDELK----------------LQLAKKEEELQGA 1095
Query: 360 IAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMML 419
+A+ D T + L + + +A LQ +E E +Q +L +EL L
Sbjct: 1096 LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE----AL 1151
Query: 420 YKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFL-----THGN-LEE 473
+LE D + +QQ ++ L + LE E K E + H LEE
Sbjct: 1152 KTELEDTLDTTAAQQ----ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE 1207
Query: 474 VAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH 533
++E+L+Q + + +++ L NK++ L Q + ++L Q
Sbjct: 1208 LSEQLEQ-----AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 534 KVESQLNKLNHLLTDILADVKTKRKTLAN-NKLHQMEREFYVYFLKD----EDYLKDIVE 588
++ +++++ + L ++ + L N + L + + + F KD E L+D E
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 589 NLETQSKIK 597
L+ +++ K
Sbjct: 1323 LLQEETRQK 1331
Score = 41.6 bits (96), Expect = 0.002
Identities = 106/568 (18%), Positives = 211/568 (37%), Gaps = 98/568 (17%)
Query: 86 TSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRL----NAKE 141
T++ K ++++ E+ LED+ +K K L R +C + K+ L N +E
Sbjct: 975 TAEAKIKKMEE-EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033
Query: 142 ------EEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFL 195
EE KK ++++ L K+ E L D++ +L L
Sbjct: 1034 VMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL---------- 1083
Query: 196 SQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEIL 255
+ +EE+ AL +G E + +N +++ I + QE
Sbjct: 1084 ------QLAKKEEELQGALA--------RGDDETLHKNNA--LKVVRELQAQIAELQEDF 1127
Query: 256 EERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKIS 315
E + + A+ Q L ++K+ ++ ++ + +E A++
Sbjct: 1128 ESEKASRNK-------AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 316 -SLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVL 374
+L E E ++ ++ R A+ + QL K + L+ KQ T +EL
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN--LEKNKQGLETDNKELAC 1238
Query: 375 N----QLIKQKASFELLQLSYEIE----------------LRKHRDIYRQLEN---LVQE 411
Q +K ++ + +L +++ K + +L+N L++E
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 412 LSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNL 471
+ + K L Q + K + R+ Q+ E +N +E
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE---QQEEE 1355
Query: 472 EEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQ 531
EE + L++ + +Q QLA + K+ D D+ + + LL D E Q
Sbjct: 1356 EEARKNLEKQVLALQSQLADT---------KKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 532 --------FHKVESQLNKLNHLLTDILADVKTKRKTLAN--------NKLHQMEREFYVY 575
+ K+E N+L L D+ D+ +R+ +N ++L E+
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 576 FLKDEDYLKDIVENLETQSKIKAVSLED 603
+ ++ D + ET++ A +LE+
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEE 1494
Score = 36.6 bits (83), Expect = 0.068
Identities = 81/418 (19%), Positives = 168/418 (40%), Gaps = 52/418 (12%)
Query: 95 DDKELEKLEDEVQTLLKLKNLK--------IQRRNKCQLMASV----TSHKSLRLNAKEE 142
D E E E E + L + L+ +R+NK QL A + +S + N E
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNK-QLRADMEDLMSSKDDVGKNVHEL 1530
Query: 143 EATKK-LKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLE 201
E +K+ L+Q + + ++ +ELQA D +L + N +QF +
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV-----------NMQAMKAQFERD 1579
Query: 202 KYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLE 261
E+ K+ + + E+ ++ Q + ++ +++ + +
Sbjct: 1580 LQTRDEQNEEK------KRLLIKQVRELEAELEDERKQ----RALAVASKKKMEIDLKDL 1629
Query: 262 MARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEI 321
A+++ A + L+ + MK + EE+ S + + K+ SL +EI
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689
Query: 322 MKLEKEVTQIKDRSLPAVVRENAQLLN-MPVVKGDFDLQIAKQDYYTARQELVLNQLIKQ 380
++L++E+ +R+ +E +L + + + ++ AR + +L ++
Sbjct: 1690 LQLQEELAS-SERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748
Query: 381 KASFELLQLSY----------EIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPS 430
+++ ELL + EL R ++ +N Q+L + N L +L+ L
Sbjct: 1749 QSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Query: 431 VSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQ 488
S+ + TI + +L + LE E KE + + +KLK+ V+D+
Sbjct: 1809 KSKF---KATISALEAKIGQLEEQLEQE--AKERAAANKLVRRTEKKLKEIFMQVEDE 1861
Score = 30.0 bits (66), Expect = 6.4
Identities = 65/333 (19%), Positives = 126/333 (37%), Gaps = 54/333 (16%)
Query: 49 EQNVLSERELEAFSILQKSGKPI--------LEGA--ALDEALKTCKT--SDLKTPRLDD 96
E + ER+ A ++ K I +E A A DE +K + + +K + +
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 97 KELEKLEDEV--QTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEE------EATKKL 148
+E DE+ Q+ K LK QL + S + R +A++E E T
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 149 KQSQGILN------AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEK 202
+L+ A I ++ EL+ + L FR + L T ++ + E+
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT----LNAELAAER 1777
Query: 203 YLSQEEQSTAALTLYTKKQF---FQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERR 259
+Q+ + K+ Q + V+S + L+ + + +E LE+
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL---EEQLEQEA 1834
Query: 260 LEMA-----------RLQLAYICAQHQLIH-------LKASNSSMKSSIKWAEESLHSLT 301
E A +L+ ++ + + H ++ +N+ MK + EE+ T
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 302 SKAVDKENLDAKISSLTSEIMKLEKEVTQIKDR 334
+ L ++ T L +EV+ +K+R
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREVSTLKNR 1927
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 55.1 bits (131), Expect = 2e-07
Identities = 105/500 (21%), Positives = 206/500 (41%), Gaps = 66/500 (13%)
Query: 97 KELEKLEDEVQTLLKL--KNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGI 154
KE +LE ++TL + + +KI + L +V+S + R E K +++ I
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISAEARVKDIEKENKI 591
Query: 155 LNAMITKISNELQALTDEVTQLMMFFRH-SNLGQGTNPLVF-LSQFSLEKYLSQEEQSTA 212
L+ I + S++L + E Q+ H G+ L L E L Q++ +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 213 ALTLYTKKQFFQGIHEVVESSNE-----DNFQLLDIQTPSICDNQEILEERRLEMARLQL 267
+T + Q E+ + + D+F+ L Q S+ L+E LE+ R
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 268 AYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEK- 326
+ CA ++ L+ N ++S + ++ L L + E L+ L E +L+K
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 327 -EVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFE 385
E + K + L + + ++ ++ N + K +L+I+ + L QL K+ S E
Sbjct: 772 LENSNKKIQQLESEL-QDLEMENQTLQKNLEELKISSKR---------LEQLEKENKSLE 821
Query: 386 LLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQ------QINPRN 439
QLE ++L + N L +Q E + D ++ + + N
Sbjct: 822 --------------QETSQLEKDKKQLEKENKRLRQQAE-IKDTTLEENNVKIGNLEKEN 866
Query: 440 TIDTKDYSTHR--LYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHS 497
+K+ ++ ++ E E + KEL ++ +K ++L +D ++ +
Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKEL------VKRATIDIKTLVTLREDLVSEKLK--- 917
Query: 498 FFLSKRNKDVDMLCDTLYQGG--NQLLLSDQELTEQFH------KVESQLNKLNHLLTDI 549
+ N D++ L L + G + LL D++ T+ K+ES L K + +
Sbjct: 918 --TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEK 975
Query: 550 LA--DVKTKRKTLANNKLHQ 567
+A + + + T N +L Q
Sbjct: 976 IAALEARLEESTNYNQQLRQ 995
Score = 47.0 bits (110), Expect = 5e-05
Identities = 116/573 (20%), Positives = 228/573 (39%), Gaps = 131/573 (22%)
Query: 64 LQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEV----QTLLKLKNLKIQR 119
L+K K + + A + + T + +++K L+ KE + L E+ ++ ++LK L ++
Sbjct: 834 LEKENKRLRQQAEIKDT--TLEENNVKIGNLE-KENKTLSKEIGIYKESCVRLKEL--EK 888
Query: 120 RNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMF 179
NK +L+ T + +E+ ++KLK Q +N + K+++EL+ + +L+
Sbjct: 889 ENK-ELVKRATIDIKTLVTLREDLVSEKLKTQQ--MNNDLEKLTHELEKIGLNKERLL-- 943
Query: 180 FRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQ 239
H Q T+ S K L + +ST +L K++ + +E S N Q
Sbjct: 944 --HDE--QSTDD-------SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 992
Query: 240 LLDIQTPSICDNQEILEERRLEMARLQLA--------------------YICAQHQLIHL 279
L + ++ N E L++R+ E +Q + + + +LI +
Sbjct: 993 LRQ-ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
Query: 280 KASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT---------Q 330
+ +N+++++ + + L L ++ NL A+I +L + + L+++ T Q
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQ---NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
Query: 331 IKDRSL----PAVVRENAQLL---------NMPVVKGDFDLQIAKQDYYTARQELVL--- 374
+++ +L +++ +NAQLL N V+K DL+ ++L L
Sbjct: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHE 1168
Query: 375 ----------------------------------NQLIKQKASFELLQLSYEIELRK--- 397
NQL+KQK E L+ ++E K
Sbjct: 1169 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1228
Query: 398 ----HRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQ 453
H + + + L E + N Y QL T+ + N ++ ++ RL
Sbjct: 1229 ENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL-- 1285
Query: 454 VLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDT 513
E + +L + L+ + KL L+ +E+ L + T
Sbjct: 1286 ----EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ--------IQT 1333
Query: 514 LYQGGNQLLLSDQELTEQFHKVESQ-LNKLNHL 545
L LL + E + FH + Q ++KLN L
Sbjct: 1334 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Score = 44.3 bits (103), Expect = 3e-04
Identities = 122/578 (21%), Positives = 233/578 (40%), Gaps = 100/578 (17%)
Query: 48 NEQNVLSERELEAFSILQKSGKPILEGAAL------DEALKTCKT-SDLKTPRLDDKELE 100
N++NV + +E + Q+ +P+L+ AL DE + +T +L R L
Sbjct: 166 NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 225
Query: 101 KLEDEVQTLLKLKNLK-IQRRNKCQLMASVTSHKSLRLNAKEEEATKKL---KQSQGILN 156
Q+ +K + R + + K RL + EE T++L KQ +
Sbjct: 226 HASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQME 285
Query: 157 AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTL 216
+ ++ E L + M+ L V + + LE +S+ ++ +
Sbjct: 286 IELKRLQQENMNLLSDARSARMY--RDELDALREKAVRVDK--LESEVSRYKERLHDIEF 341
Query: 217 YTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQL 276
Y + VE EDN LL+ +T + E +LE R + +L
Sbjct: 342 YKAR---------VEELKEDNQVLLETKT---------MLEDQLEGTRAR------SDKL 377
Query: 277 IHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSL 336
L+ N +K+ LH + ++++ KI L E M LE Q D SL
Sbjct: 378 HELEKENLQLKA-------KLHDM---EMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 337 P-----AVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSY 391
+ ++L P ++ EL ++L+K + + L +
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEV-----------NELTSSRLLKLEMENQSLTKTV 476
Query: 392 EIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTID-TKDYSTHR 450
E ELR D + + ++ + N L K++E+L + V ++ + +N + +KD +
Sbjct: 477 E-ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK 535
Query: 451 --LYQVLE--GENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKD 506
L + +E EN ++++ + LE+ E L Q +S ++ + +SA+ R KD
Sbjct: 536 AQLEKTIETLRENSERQIKI----LEQENEHLNQTVSSLRQRSQISAE-------ARVKD 584
Query: 507 VDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLH 566
++ L++ S +E + + K+E + ++ L K +R N+LH
Sbjct: 585 IEKENKILHE-------SIKETSSKLSKIEFEKRQIKKELEHY--KEKGERAEELENELH 635
Query: 567 QMEREFYVYFLKDEDYLKDIVENLE-TQSKIKAVSLED 603
+E K+ + L+ + NL+ T KI+A+ E+
Sbjct: 636 HLE--------KENELLQKKITNLKITCEKIEALEQEN 665
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 54.3 bits (129), Expect = 3e-07
Identities = 117/547 (21%), Positives = 222/547 (40%), Gaps = 68/547 (12%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKC--QLMASVTSHKSLRLNAKEEEATKKLKQSQG 153
+ +L+KLE+E Q +L+ +N K+ + K +A T++ + +EEE +K L + +
Sbjct: 970 EAKLKKLEEE-QIILEDQNCKLAKEKKLLEDRIAEFTTNLT-----EEEEKSKSLAKLKN 1023
Query: 154 ILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAA 213
AMIT + L+ ++ Q + R G T+ L +++ + A
Sbjct: 1024 KHEAMITDLEERLRR-EEKQRQELEKTRRKLEGDSTD---------LSDQIAELQAQIAE 1073
Query: 214 LTLYTKK---QFFQGIHEVVESSNEDNFQLLDIQ--TPSICDNQEILEERRLEMARLQLA 268
L + K + + V E + + N L I+ I + QE LE R + +
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 269 YICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEV 328
+L LK S +E L SK + N+ K +L E E ++
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQE----LRSKREQEVNILKK--TLEEEAKTHEAQI 1187
Query: 329 TQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELV--LNQLIKQKASFEL 386
+++ + AV QL VK +L+ AKQ R EL + L++ K E
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKA--NLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245
Query: 387 LQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDY 446
+ E +L++ + + + E + EL+ L +L+ +T + Q + +++ TKD+
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT--GLLSQSDSKSSKLTKDF 1303
Query: 447 ST-----HRLYQVLEGENKKKELFLTH---------------GNLEEVAEKLKQNISLVQ 486
S ++L+ EN++K T EE L++ I+ +
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 487 DQLA--VSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNH 544
Q+A E S + ++V +G +Q +E + K+E +L
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ---RHEEKVAAYDKLEKTKTRLQQ 1420
Query: 545 LLTDILADVKTKRKTLAN--------NKLHQMEREFYVYFLKDEDYLKDIVENLETQSKI 596
L D+L D+ +R++ N ++L E+ + ++ D + ET++
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 597 KAVSLED 603
A +LE+
Sbjct: 1481 LARALEE 1487
Score = 48.5 bits (114), Expect = 2e-05
Identities = 116/548 (21%), Positives = 204/548 (37%), Gaps = 83/548 (15%)
Query: 57 ELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLK 116
E + + QK + + E A E K K + K + + E +L +EV+ LL+ K
Sbjct: 1184 EAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG-- 1241
Query: 117 IQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQL 176
+ HK ++ A+ +E K + + + + K++ +LQ D VT L
Sbjct: 1242 ------------DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT-KLQVELDNVTGL 1288
Query: 177 MMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNED 236
+ + + SQ + L QEE + L+L TK + +V + N
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEE-NRQKLSLSTK------LKQVEDEKNSF 1341
Query: 237 NFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEES 296
QL + EE Q+A + AQ + +K ++ AEE
Sbjct: 1342 REQLEE-------------EEEAKHNLEKQIATLHAQ--VADMKKKMEDSVGCLETAEEV 1386
Query: 297 LHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIK---DRSLPAVVRENAQLLNMPVVK 353
L D E L + + KLEK T+++ D L + + N+ +
Sbjct: 1387 KRKLQK---DLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 354 GDFDLQIAKQDYYTARQE---------------------LVLNQLIKQKASFELLQLSYE 392
FD +A++ +A+ L + ++QKA E L +
Sbjct: 1444 KKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR 1503
Query: 393 IELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLY 452
E+ + V EL +S L +Q+E + + + T D K RL
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK----LRLE 1559
Query: 453 QVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQD---QLAVSAQEHSFFLSKRN----- 504
L+ + E L G E+ EK KQ + V++ +L ++ S ++ R
Sbjct: 1560 VNLQAMKAQFERDL-QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 505 -KDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANN 563
KD++ D+ + ++ + ++L Q +L+ +ILA K K
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK----- 1673
Query: 564 KLHQMERE 571
KL ME E
Sbjct: 1674 KLKSMEAE 1681
Score = 44.3 bits (103), Expect = 3e-04
Identities = 97/483 (20%), Positives = 186/483 (38%), Gaps = 82/483 (16%)
Query: 99 LEKLEDEVQTLLKLKNLKIQRR-NKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNA 157
++ L+ LKL+N + R K + + V S + + AKEEE K +++ Q
Sbjct: 809 MKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQV-SRQEEEMMAKEEELVK-VREKQLAAEN 866
Query: 158 MITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLY 217
+T++ L E QL Q E L E + A
Sbjct: 867 RLTEMETLQSQLMAEKLQLQ------------------EQLQAETELCAEAEELRARLTA 908
Query: 218 TKKQFFQGIHEVVESSNEDNFQLLDIQTP------SICDNQEILEERRLEMARLQLAYIC 271
K++ + H++ E+ + +Q +I + +E LEE +LQL +
Sbjct: 909 KKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 272 AQHQL-------IHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKL 324
+ +L I L+ N + K E+ + T+ ++E ++ L + K
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN---KH 1025
Query: 325 EKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELV--LNQLIKQKA 382
E +T +++R + RE Q +Q+ R++L L Q A
Sbjct: 1026 EAMITDLEER----LRREEKQ----------------RQELEKTRRKLEGDSTDLSDQIA 1065
Query: 383 SFELLQLSYEIEL-RKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTI 441
+ +++L +K ++ L + +E +Q NM L K E+ + S Q+
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE------- 1118
Query: 442 DTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLS 501
D + R + + E +K++L E E LK + D A + S
Sbjct: 1119 ---DLESERASRN-KAEKQKRDL-------GEELEALKTELEDTLDSTAAQQE----LRS 1163
Query: 502 KRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLA 561
KR ++V++L TL + QE+ ++ + +L + + A+++ ++TL
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE 1223
Query: 562 NNK 564
N +
Sbjct: 1224 NER 1226
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 54.3 bits (129), Expect = 3e-07
Identities = 106/518 (20%), Positives = 202/518 (38%), Gaps = 86/518 (16%)
Query: 69 KPILEGAALDEALKTCKTSDLKTPRLDDK---ELEKLEDEVQTLLKLKNLKIQRRNKCQL 125
KP+L+ +E ++ + KT K EL++LE + L + KNL ++
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 126 MASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNL 185
+ + +RL AK++E + L + + L + +LQA ++ Q M+
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQML------- 953
Query: 186 GQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQT 245
LE+ L +EE + L Q + E ED ++D Q
Sbjct: 954 -------------DLEEQLEEEEAARQKL------QLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 246 PSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSS----IKWAEESLHSLT 301
+ +++LEER ++ L LK + SM S +K E+S L
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 302 SKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQ-- 359
K L+ S +I L+ ++ ++K M + K + +LQ
Sbjct: 1055 KL---KRKLEGDASDFHEQIADLQAQIAELK----------------MQLAKKEEELQAA 1095
Query: 360 IAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMML 419
+A+ D A++ L ++ + + LQ + E +Q +L +EL L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----AL 1151
Query: 420 YKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLK 479
+LE D + +QQ ++ L + L+ E + E ++E+ +K
Sbjct: 1152 KTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHE-----AQVQEMRQKHA 1202
Query: 480 QNISLVQDQL------AVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH 533
Q + + +QL + ++ L K N D+ L Q + QE+ +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-------AKQEVEHKKK 1255
Query: 534 KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMERE 571
K+E+Q+ +L +D + + N+K+H+++ E
Sbjct: 1256 KLEAQVQELQSKCSD-----GERARAELNDKVHKLQNE 1288
Score = 46.6 bits (109), Expect = 7e-05
Identities = 112/558 (20%), Positives = 229/558 (41%), Gaps = 98/558 (17%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+ +++KLEDE+ ++ +N K+ + K L+ S + L A+EEE K L + +
Sbjct: 977 EAKIKKLEDEI-LVMDDQNNKLSKERK--LLEERISDLTTNL-AEEEEKAKNLTKLKNKH 1032
Query: 156 NAMITKISNELQALTDEVTQLMMFFR---------HSNLGQGTNPLVFLSQFSLEKYLSQ 206
+MI+++ L+ +L R H + + L +K
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---- 1088
Query: 207 EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQ 266
EE+ AAL + + + N ++ +++ I D QE L+ R + +
Sbjct: 1089 EEELQAALAR---------LDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAE 1138
Query: 267 LAYICAQHQLIHLKAS------NSSMKSSIKWAEESLHSLTSKAVDKENL--DAKISSLT 318
+L LK +++ + ++ E ++ KA+D+E +A++ +
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 319 SE----IMKLEKEVTQIK------DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTA 368
+ + +L +++ Q K D++ + +ENA L V G AKQ+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-----AKQEVEHK 1253
Query: 369 RQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY----KQLE 424
+++L +A + LQ R ++ ++ L E+ ML K ++
Sbjct: 1254 KKKL--------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 425 MLTD-PSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE-------EVAE 476
+ D S+S Q+ DT++ Q L K ++L +L+ E +
Sbjct: 1306 LAKDVASLSSQLQ-----DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 477 KLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH--- 533
L+++IS + QL+ S K+ +D + L +G + + LT+Q+
Sbjct: 1361 NLERHISTLNIQLSDS--------KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 534 ----KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYL------ 583
K+E N+L L D++ D+ +R+ ++N L + +R+F ++++
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 584 KDIVENLETQSKIKAVSL 601
+D E + + KA+SL
Sbjct: 1471 RDRAEAEAREKETKALSL 1488
Score = 34.7 bits (78), Expect = 0.26
Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 20/301 (6%)
Query: 268 AYICAQHQLIHLKASNSSMKSSIK---WAEESLHSLTSKAVDKENLDAKISSLTSEIMKL 324
A+ Q QL +K + + +K W L + + + ++ + E+ K
Sbjct: 805 AFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKT 864
Query: 325 EKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASF 384
KE Q + L + ++++QL + + LQ A+ + Y +E+ + K++
Sbjct: 865 -KERQQKAENELKELEQKHSQLTEEKNLLQE-QLQ-AETELYAEAEEMRVRLAAKKQELE 921
Query: 385 ELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQIN-PRNTIDT 443
E+L E L + D +QL+ ++++Q + L +QLE + + Q++ + T +
Sbjct: 922 EILH-EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAARQKLQLEKVTAEA 978
Query: 444 KDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKR 503
K V++ +N K L + + L++ IS + LA ++ +
Sbjct: 979 KIKKLEDEILVMDDQNNK---------LSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 504 NKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANN 563
NK M+ + L + S QEL + K+E + + + D+ A + + LA
Sbjct: 1030 NKHESMISE-LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 564 K 564
+
Sbjct: 1089 E 1089
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 54.3 bits (129), Expect = 3e-07
Identities = 106/518 (20%), Positives = 202/518 (38%), Gaps = 86/518 (16%)
Query: 69 KPILEGAALDEALKTCKTSDLKTPRLDDK---ELEKLEDEVQTLLKLKNLKIQRRNKCQL 125
KP+L+ +E ++ + KT K EL++LE + L + KNL ++
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 126 MASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNL 185
+ + +RL AK++E + L + + L + +LQA ++ Q M+
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQML------- 960
Query: 186 GQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQT 245
LE+ L +EE + L Q + E ED ++D Q
Sbjct: 961 -------------DLEEQLEEEEAARQKL------QLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 246 PSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSS----IKWAEESLHSLT 301
+ +++LEER ++ L LK + SM S +K E+S L
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 302 SKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQ-- 359
K L+ S +I L+ ++ ++K M + K + +LQ
Sbjct: 1062 KL---KRKLEGDASDFHEQIADLQAQIAELK----------------MQLAKKEEELQAA 1102
Query: 360 IAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMML 419
+A+ D A++ L ++ + + LQ + E +Q +L +EL L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----AL 1158
Query: 420 YKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLK 479
+LE D + +QQ ++ L + L+ E + E ++E+ +K
Sbjct: 1159 KTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHE-----AQVQEMRQKHA 1209
Query: 480 QNISLVQDQL------AVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH 533
Q + + +QL + ++ L K N D+ L Q + QE+ +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-------AKQEVEHKKK 1262
Query: 534 KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMERE 571
K+E+Q+ +L +D + + N+K+H+++ E
Sbjct: 1263 KLEAQVQELQSKCSD-----GERARAELNDKVHKLQNE 1295
Score = 46.6 bits (109), Expect = 7e-05
Identities = 112/558 (20%), Positives = 229/558 (41%), Gaps = 98/558 (17%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+ +++KLEDE+ ++ +N K+ + K L+ S + L A+EEE K L + +
Sbjct: 984 EAKIKKLEDEI-LVMDDQNNKLSKERK--LLEERISDLTTNL-AEEEEKAKNLTKLKNKH 1039
Query: 156 NAMITKISNELQALTDEVTQLMMFFR---------HSNLGQGTNPLVFLSQFSLEKYLSQ 206
+MI+++ L+ +L R H + + L +K
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---- 1095
Query: 207 EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQ 266
EE+ AAL + + + N ++ +++ I D QE L+ R + +
Sbjct: 1096 EEELQAALAR---------LDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAE 1145
Query: 267 LAYICAQHQLIHLKAS------NSSMKSSIKWAEESLHSLTSKAVDKENL--DAKISSLT 318
+L LK +++ + ++ E ++ KA+D+E +A++ +
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 319 SE----IMKLEKEVTQIK------DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTA 368
+ + +L +++ Q K D++ + +ENA L V G AKQ+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-----AKQEVEHK 1260
Query: 369 RQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY----KQLE 424
+++L +A + LQ R ++ ++ L E+ ML K ++
Sbjct: 1261 KKKL--------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 425 MLTD-PSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE-------EVAE 476
+ D S+S Q+ DT++ Q L K ++L +L+ E +
Sbjct: 1313 LAKDVASLSSQLQ-----DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 477 KLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH--- 533
L+++IS + QL+ S K+ +D + L +G + + LT+Q+
Sbjct: 1368 NLERHISTLNIQLSDS--------KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 534 ----KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYL------ 583
K+E N+L L D++ D+ +R+ ++N L + +R+F ++++
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 584 KDIVENLETQSKIKAVSL 601
+D E + + KA+SL
Sbjct: 1478 RDRAEAEAREKETKALSL 1495
Score = 34.7 bits (78), Expect = 0.26
Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 20/301 (6%)
Query: 268 AYICAQHQLIHLKASNSSMKSSIK---WAEESLHSLTSKAVDKENLDAKISSLTSEIMKL 324
A+ Q QL +K + + +K W L + + + ++ + E+ K
Sbjct: 812 AFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKT 871
Query: 325 EKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASF 384
KE Q + L + ++++QL + + LQ A+ + Y +E+ + K++
Sbjct: 872 -KERQQKAENELKELEQKHSQLTEEKNLLQE-QLQ-AETELYAEAEEMRVRLAAKKQELE 928
Query: 385 ELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQIN-PRNTIDT 443
E+L E L + D +QL+ ++++Q + L +QLE + + Q++ + T +
Sbjct: 929 EILH-EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAARQKLQLEKVTAEA 985
Query: 444 KDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKR 503
K V++ +N K L + + L++ IS + LA ++ +
Sbjct: 986 KIKKLEDEILVMDDQNNK---------LSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 504 NKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANN 563
NK M+ + L + S QEL + K+E + + + D+ A + + LA
Sbjct: 1037 NKHESMISE-LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 564 K 564
+
Sbjct: 1096 E 1096
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 54.3 bits (129), Expect = 3e-07
Identities = 106/518 (20%), Positives = 202/518 (38%), Gaps = 86/518 (16%)
Query: 69 KPILEGAALDEALKTCKTSDLKTPRLDDK---ELEKLEDEVQTLLKLKNLKIQRRNKCQL 125
KP+L+ +E ++ + KT K EL++LE + L + KNL ++
Sbjct: 849 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 908
Query: 126 MASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNL 185
+ + +RL AK++E + L + + L + +LQA ++ Q M+
Sbjct: 909 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQML------- 960
Query: 186 GQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQT 245
LE+ L +EE + L Q + E ED ++D Q
Sbjct: 961 -------------DLEEQLEEEEAARQKL------QLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 246 PSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSS----IKWAEESLHSLT 301
+ +++LEER ++ L LK + SM S +K E+S L
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Query: 302 SKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQ-- 359
K L+ S +I L+ ++ ++K M + K + +LQ
Sbjct: 1062 KL---KRKLEGDASDFHEQIADLQAQIAELK----------------MQLAKKEEELQAA 1102
Query: 360 IAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMML 419
+A+ D A++ L ++ + + LQ + E +Q +L +EL L
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----AL 1158
Query: 420 YKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLK 479
+LE D + +QQ ++ L + L+ E + E ++E+ +K
Sbjct: 1159 KTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHE-----AQVQEMRQKHA 1209
Query: 480 QNISLVQDQL------AVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH 533
Q + + +QL + ++ L K N D+ L Q + QE+ +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-------AKQEVEHKKK 1262
Query: 534 KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMERE 571
K+E+Q+ +L +D + + N+K+H+++ E
Sbjct: 1263 KLEAQVQELQSKCSD-----GERARAELNDKVHKLQNE 1295
Score = 46.6 bits (109), Expect = 7e-05
Identities = 112/558 (20%), Positives = 229/558 (41%), Gaps = 98/558 (17%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+ +++KLEDE+ ++ +N K+ + K L+ S + L A+EEE K L + +
Sbjct: 984 EAKIKKLEDEI-LVMDDQNNKLSKERK--LLEERISDLTTNL-AEEEEKAKNLTKLKNKH 1039
Query: 156 NAMITKISNELQALTDEVTQLMMFFR---------HSNLGQGTNPLVFLSQFSLEKYLSQ 206
+MI+++ L+ +L R H + + L +K
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---- 1095
Query: 207 EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQ 266
EE+ AAL + + + N ++ +++ I D QE L+ R + +
Sbjct: 1096 EEELQAALAR---------LDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAE 1145
Query: 267 LAYICAQHQLIHLKAS------NSSMKSSIKWAEESLHSLTSKAVDKENL--DAKISSLT 318
+L LK +++ + ++ E ++ KA+D+E +A++ +
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 319 SE----IMKLEKEVTQIK------DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTA 368
+ + +L +++ Q K D++ + +ENA L V G AKQ+
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-----AKQEVEHK 1260
Query: 369 RQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY----KQLE 424
+++L +A + LQ R ++ ++ L E+ ML K ++
Sbjct: 1261 KKKL--------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 425 MLTD-PSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE-------EVAE 476
+ D S+S Q+ DT++ Q L K ++L +L+ E +
Sbjct: 1313 LAKDVASLSSQLQ-----DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 477 KLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH--- 533
L+++IS + QL+ S K+ +D + L +G + + LT+Q+
Sbjct: 1368 NLERHISTLNIQLSDS--------KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 534 ----KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYL------ 583
K+E N+L L D++ D+ +R+ ++N L + +R+F ++++
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADE 1477
Query: 584 KDIVENLETQSKIKAVSL 601
+D E + + KA+SL
Sbjct: 1478 RDRAEAEAREKETKALSL 1495
Score = 34.7 bits (78), Expect = 0.26
Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 20/301 (6%)
Query: 268 AYICAQHQLIHLKASNSSMKSSIK---WAEESLHSLTSKAVDKENLDAKISSLTSEIMKL 324
A+ Q QL +K + + +K W L + + + ++ + E+ K
Sbjct: 812 AFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKT 871
Query: 325 EKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASF 384
KE Q + L + ++++QL + + LQ A+ + Y +E+ + K++
Sbjct: 872 -KERQQKAENELKELEQKHSQLTEEKNLLQE-QLQ-AETELYAEAEEMRVRLAAKKQELE 928
Query: 385 ELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQIN-PRNTIDT 443
E+L E L + D +QL+ ++++Q + L +QLE + + Q++ + T +
Sbjct: 929 EILH-EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAARQKLQLEKVTAEA 985
Query: 444 KDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKR 503
K V++ +N K L + + L++ IS + LA ++ +
Sbjct: 986 KIKKLEDEILVMDDQNNK---------LSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 504 NKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANN 563
NK M+ + L + S QEL + K+E + + + D+ A + + LA
Sbjct: 1037 NKHESMISE-LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 564 K 564
+
Sbjct: 1096 E 1096
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 54.3 bits (129), Expect = 3e-07
Identities = 106/518 (20%), Positives = 202/518 (38%), Gaps = 86/518 (16%)
Query: 69 KPILEGAALDEALKTCKTSDLKTPRLDDK---ELEKLEDEVQTLLKLKNLKIQRRNKCQL 125
KP+L+ +E ++ + KT K EL++LE + L + KNL ++
Sbjct: 842 KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE 901
Query: 126 MASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNL 185
+ + +RL AK++E + L + + L + +LQA ++ Q M+
Sbjct: 902 LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAERKKMAQQML------- 953
Query: 186 GQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQT 245
LE+ L +EE + L Q + E ED ++D Q
Sbjct: 954 -------------DLEEQLEEEEAARQKL------QLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 246 PSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSS----IKWAEESLHSLT 301
+ +++LEER ++ L LK + SM S +K E+S L
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Query: 302 SKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQ-- 359
K L+ S +I L+ ++ ++K M + K + +LQ
Sbjct: 1055 KL---KRKLEGDASDFHEQIADLQAQIAELK----------------MQLAKKEEELQAA 1095
Query: 360 IAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMML 419
+A+ D A++ L ++ + + LQ + E +Q +L +EL L
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE----AL 1151
Query: 420 YKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLK 479
+LE D + +QQ ++ L + L+ E + E ++E+ +K
Sbjct: 1152 KTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHE-----AQVQEMRQKHA 1202
Query: 480 QNISLVQDQL------AVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH 533
Q + + +QL + ++ L K N D+ L Q + QE+ +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-------AKQEVEHKKK 1255
Query: 534 KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMERE 571
K+E+Q+ +L +D + + N+K+H+++ E
Sbjct: 1256 KLEAQVQELQSKCSD-----GERARAELNDKVHKLQNE 1288
Score = 46.6 bits (109), Expect = 7e-05
Identities = 112/558 (20%), Positives = 229/558 (41%), Gaps = 98/558 (17%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+ +++KLEDE+ ++ +N K+ + K L+ S + L A+EEE K L + +
Sbjct: 977 EAKIKKLEDEI-LVMDDQNNKLSKERK--LLEERISDLTTNL-AEEEEKAKNLTKLKNKH 1032
Query: 156 NAMITKISNELQALTDEVTQLMMFFR---------HSNLGQGTNPLVFLSQFSLEKYLSQ 206
+MI+++ L+ +L R H + + L +K
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---- 1088
Query: 207 EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQ 266
EE+ AAL + + + N ++ +++ I D QE L+ R + +
Sbjct: 1089 EEELQAALAR---------LDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAE 1138
Query: 267 LAYICAQHQLIHLKAS------NSSMKSSIKWAEESLHSLTSKAVDKENL--DAKISSLT 318
+L LK +++ + ++ E ++ KA+D+E +A++ +
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 319 SE----IMKLEKEVTQIK------DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTA 368
+ + +L +++ Q K D++ + +ENA L V G AKQ+
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ-----AKQEVEHK 1253
Query: 369 RQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLY----KQLE 424
+++L +A + LQ R ++ ++ L E+ ML K ++
Sbjct: 1254 KKKL--------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 425 MLTD-PSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE-------EVAE 476
+ D S+S Q+ DT++ Q L K ++L +L+ E +
Sbjct: 1306 LAKDVASLSSQLQ-----DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 477 KLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFH--- 533
L+++IS + QL+ S K+ +D + L +G + + LT+Q+
Sbjct: 1361 NLERHISTLNIQLSDS--------KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 534 ----KVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYL------ 583
K+E N+L L D++ D+ +R+ ++N L + +R+F ++++
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEKKQRKFDQLLAEEKNISSKYADE 1470
Query: 584 KDIVENLETQSKIKAVSL 601
+D E + + KA+SL
Sbjct: 1471 RDRAEAEAREKETKALSL 1488
Score = 34.7 bits (78), Expect = 0.26
Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 20/301 (6%)
Query: 268 AYICAQHQLIHLKASNSSMKSSIK---WAEESLHSLTSKAVDKENLDAKISSLTSEIMKL 324
A+ Q QL +K + + +K W L + + + ++ + E+ K
Sbjct: 805 AFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKT 864
Query: 325 EKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASF 384
KE Q + L + ++++QL + + LQ A+ + Y +E+ + K++
Sbjct: 865 -KERQQKAENELKELEQKHSQLTEEKNLLQE-QLQ-AETELYAEAEEMRVRLAAKKQELE 921
Query: 385 ELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQIN-PRNTIDT 443
E+L E L + D +QL+ ++++Q + L +QLE + + Q++ + T +
Sbjct: 922 EILH-EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAARQKLQLEKVTAEA 978
Query: 444 KDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKR 503
K V++ +N K L + + L++ IS + LA ++ +
Sbjct: 979 KIKKLEDEILVMDDQNNK---------LSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 504 NKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANN 563
NK M+ + L + S QEL + K+E + + + D+ A + + LA
Sbjct: 1030 NKHESMISE-LEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 564 K 564
+
Sbjct: 1089 E 1089
>gi|110815815 centlein isoform 1 [Homo sapiens]
Length = 1406
Score = 53.1 bits (126), Expect = 7e-07
Identities = 120/581 (20%), Positives = 239/581 (41%), Gaps = 68/581 (11%)
Query: 47 VNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEV 106
V+E+N +E FS L+K K + + + K C + + RL K LE+ ++
Sbjct: 197 VDEENAFLRKE---FSDLEKKFK---DKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKL 250
Query: 107 QTLLK--LKNLKIQRRNKCQLMASVTSHKSLRLNAKEE---EATKKLKQSQGILNAMITK 161
T L +L+ R+ + L S + ++ E+ EA K+++ SQ NA+ +
Sbjct: 251 STRCTDLLNDLEKLRKQEAHLRKEKYSTDA-KIKTFEDNLIEARKEVEVSQSKYNALSLQ 309
Query: 162 ISN----------ELQALTDEVTQLMMFFRHSNL-----GQGTNPLVFLSQFSLEKYLSQ 206
+SN ++ + E+ +L ++ ++ + L L+ + + +Q
Sbjct: 310 LSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQ 369
Query: 207 EEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQ 266
E+ TA Y K + +H E++ + L S+ + Q+ L ++ E A+L+
Sbjct: 370 EDVHTAESISYQK--LYNELHICFETTKSNEAML----RQSVTNLQDQLLQKEQENAKLK 423
Query: 267 LAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAV-DKENLDAKISSLTSEIMKLE 325
+Q + L + S+ SL SL + V K ++ L KL
Sbjct: 424 EKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLS 483
Query: 326 KEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFE 385
+ ++ K S +++ P VK L + + +T +E L +L K + E
Sbjct: 484 ENISANKGFSRKSIMTSAEGKHKEPPVKRSRSL--SPKSSFTDSEE--LQKLRKAERKIE 539
Query: 386 LLQLSYEIELRKH---RDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTID 442
L+ + +++ +++ RD + + + +Q L + + +QL+ + S +I D
Sbjct: 540 NLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRAD 599
Query: 443 ----TKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISL----VQDQLAVSAQ 494
++ S ++ + + +EL + NLEE ++LK +IS+ +Q+ A+
Sbjct: 600 PQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAE 659
Query: 495 EHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVK 554
L + +D ++ T + G ++L E L K+ L + + K
Sbjct: 660 RREEQLFRSGEDDEVKRSTPEKNGKEML-------------EQTLQKVTELENRLKSFEK 706
Query: 555 TKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSK 595
RK NK E +F LK + E+ ET+ K
Sbjct: 707 RSRKLKEGNKKLMKENDFLKSLLKQQQ------EDTETREK 741
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 52.4 bits (124), Expect = 1e-06
Identities = 99/553 (17%), Positives = 237/553 (42%), Gaps = 77/553 (13%)
Query: 37 ESFLKWFCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDD 96
+S LK N+ +L ++ FS++ ++ + + AA +E L C+ ++++ R++
Sbjct: 456 QSILKLESELENKDEILRDK----FSLMNENRELKVRVAAQNERLDLCQ-QEIESSRVEL 510
Query: 97 KELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILN 156
+ LEK+ ++ +L K + ++ ++ + KE+ + ++ +++
Sbjct: 511 RSLEKIISQLPLKRELFGFK----------SYLSKYQMSSFSNKEDRCIGCCEANKLVIS 560
Query: 157 AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTL 216
+ K++ + E+ +L H+NL +Q S + Q ++ L+
Sbjct: 561 ELRIKLAIK----EAEIQKL-----HANLTA--------NQLSQSLITCNDSQESSKLSS 603
Query: 217 YTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQL 276
+ G H+V ES + N + N++ +ER+ RL + +L
Sbjct: 604 LETEPVKLGGHQVAESVKDQNQHTM---------NKQYEKERQ----RLVTGIEELRTKL 650
Query: 277 IHLKASNSSMKSSIKWAEESLH----SLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIK 332
I ++A NS +K ++ L KA + L+++++ S+++ LEK++ + K
Sbjct: 651 IQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE-K 709
Query: 333 DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYE 392
+ ++ +NA+L + K + ++ + + T +++ L +FE + +
Sbjct: 710 IVAYSSIAAKNAELEQELMEKNE-KIRSLETNINTEHEKICL--------AFEKAK---K 757
Query: 393 IELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLY 452
I L +H+++ +Q+E L +L + + +K+ E I ++ +++ D
Sbjct: 758 IHLEQHKEMEKQIERLEAQLEKKDQQ-FKEQEKTMSMLQQDIICKQHHLESLDRLLTESK 816
Query: 453 QVLEGENKKK------------ELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFL 500
++ EN KK E + L+ E K+ + L +QL + ++ L
Sbjct: 817 GEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQL 876
Query: 501 SKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNH--LLTDILADVKTKRK 558
K++++V L L + L + ++ H ++ Q L + L D +TK +
Sbjct: 877 KKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLE 936
Query: 559 TLANNKLHQMERE 571
+ +++++
Sbjct: 937 KQVSKLEQELQKQ 949
Score = 48.5 bits (114), Expect = 2e-05
Identities = 110/599 (18%), Positives = 241/599 (40%), Gaps = 70/599 (11%)
Query: 45 GNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTS-DLKTPRLD------DK 97
G + ++N+ + L+A + + ++ LD AL+ CK L +L+ +K
Sbjct: 817 GEMKKENMKKDEALKALQ--NQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
Query: 98 ELEKLEDEVQTL---LKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGI 154
+L+K +EV L LK+KN +Q ++ ++ T + ++ +E +L+ +Q
Sbjct: 875 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 934
Query: 155 LNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAAL 214
L ++K+ ELQ + + + + + L + + + Q +
Sbjct: 935 LEKQVSKLEQELQKQRESSAEKLR--KMEEKCESAAHEADLKRQKVIELTGTARQVKIEM 992
Query: 215 TLYTKKQFFQGIHEVVESSNEDNFQLLDI-QTPSICDNQEILEERRL----EMARLQ--- 266
Y K++ + E++ + + + + Q I D + E++ E+ +LQ
Sbjct: 993 DQY-KEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHST 1051
Query: 267 ---LAYICAQHQLIHLKASNS--SMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEI 321
L + +++ + N+ +KS+++ +E L + E I LT+E+
Sbjct: 1052 ETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAEL 1111
Query: 322 MKLEKEVTQIKDRSL---PAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLI 378
+ + E+ K L A+ N +L D+ I ++ Q+++ +
Sbjct: 1112 RECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTI-REHRGEMEQKIIKLEGT 1170
Query: 379 KQKASFELLQLSYEIE-----LRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQ 433
+K+ EL + + +IE L+ ++ R+ E ++ + Q L K++E Q
Sbjct: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE-----RTQQ 1225
Query: 434 QINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE----EVAEKLKQNISLVQD-- 487
++ ++ K+ + Q E + +EL LT ++ E+AE Q + ++
Sbjct: 1226 RMKEMESV-MKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIE 1284
Query: 488 ----------QLAVSAQEHSFFLSKR---NKDVDMLCDTLYQGGNQLLLSDQELTEQFHK 534
QL+ H L++ +K + + Q + L ++ E ++ +
Sbjct: 1285 RLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYH 1344
Query: 535 VESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQ 593
+E ++ NH I AD + N +L + + E + +D V NL Q
Sbjct: 1345 MEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLEL--------EEAQDTVSNLHQQ 1395
Score = 32.7 bits (73), Expect = 0.99
Identities = 66/342 (19%), Positives = 136/342 (39%), Gaps = 40/342 (11%)
Query: 260 LEMARLQLAYI-CAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLT 318
LE A+ Q A + + Q+I+L+A S+ ++ AE L ++KE +
Sbjct: 276 LESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQ---SLQESK 332
Query: 319 SEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQ----IAKQDYYTARQELVL 374
E +KL+ ++ + + A + N L N + F K + A +E++
Sbjct: 333 EECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILE 392
Query: 375 NQLIKQKASFELLQLS---YEIELRKHRDIYRQL-ENLVQELSQSNMMLYKQLEMLTDPS 430
L + + LQ Y+ EL ++ RQL E + +M K E++ +
Sbjct: 393 RNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLT 452
Query: 431 VSQQ--INPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGN------------------ 470
S+Q + + ++ KD + ++ EN++ ++ + N
Sbjct: 453 ESRQSILKLESELENKDEILRDKFSLM-NENRELKVRVAAQNERLDLCQQEIESSRVELR 511
Query: 471 -LEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELT 529
LE++ +L L + +S + S F +K ++ + C+ N+L++S+ +
Sbjct: 512 SLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIG-CCE-----ANKLVISELRIK 565
Query: 530 EQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMERE 571
+ E Q N + + T + ++KL +E E
Sbjct: 566 LAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE 607
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 52.0 bits (123), Expect = 2e-06
Identities = 130/621 (20%), Positives = 265/621 (42%), Gaps = 106/621 (17%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDE-VQT 108
+N E E +I+++ I+E E KT + D T DK L +L+++ VQ
Sbjct: 317 ENSNKEEIQEKETIIEELNTKIIE-----EEKKTLELKDKLTTA--DKLLGELQEQIVQK 369
Query: 109 LLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQ---GILNAMITKISNE 165
++KN+K++ N Q + + EE + K SQ I+ M + +
Sbjct: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 166 LQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTA--------ALTLY 217
L+ L E+ ++ GQ +V + Q + ++++Q E+ AL Y
Sbjct: 430 LEQLRAELDEMY--------GQ---QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478
Query: 218 TKKQFFQGIHEVVESS-NEDNFQLLDIQTPSICDNQE---ILEE-----RRLEMARLQLA 268
+ + +++ + NE N +L D + +E ILEE R+LE +L+
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 269 YICAQHQLIHLKASNSSMKSSIKWAEESLHS-------LTSKAVDKENLD----AKISSL 317
+ ++ Q+ + + + +S + A +SL + + S + ++ L+ A++++
Sbjct: 539 F--SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 318 TSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQD------------- 364
++ LEKE + DR + E +L + + +L K+D
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656
Query: 365 -----YYTARQELVLNQLIK-------QKASFELLQLSYEIELRKHRDIYRQLEN-LVQE 411
+Y + + + N++ + +K + Q +E+ K +D+ + L N +E
Sbjct: 657 DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEE 716
Query: 412 LSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTH--G 469
++ L K++E+L Q+ + T++ + ++LE + K+KE L
Sbjct: 717 MTLQINELQKEIEIL-----RQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
Query: 470 NLEEVAEKLKQNISLVQDQL----AVSAQEHSFFL-SKRNKDVDMLCDTLYQGGNQLLLS 524
LE LK ++D L VS +E FL S ++K D++++ ++L+
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK----DSVWEKEIEILIE 827
Query: 525 DQE-LTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYL 583
+ E L +Q ++ ++ K + + + + +Q +E Y LK +D L
Sbjct: 828 ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN---------YQELQEEYACLLKVKDDL 878
Query: 584 KDI--VENLETQSKIKAVSLE 602
+D + LE +SK+KA++ E
Sbjct: 879 EDSKNKQELEYKSKLKALNEE 899
Score = 48.5 bits (114), Expect = 2e-05
Identities = 101/524 (19%), Positives = 211/524 (40%), Gaps = 61/524 (11%)
Query: 49 EQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDK-ELEKLEDEVQ 107
+Q + EREL + QK G + L+ +T L +L+ + + EK+ D++Q
Sbjct: 1966 QQQIQEERELLS---RQKEAMKAEAGPVEQQLLQ--ETEKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 108 TLLKLKNLKIQRR-NKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNEL 166
+K + ++ + ++ + + + + L + + K+L++ + L+ +E
Sbjct: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080
Query: 167 QALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGI 226
E+ +L + Q + L +L ++ + L L +K+Q + I
Sbjct: 2081 DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLL-SKEQLQRDI 2139
Query: 227 HEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSM 286
E E + F++ R LE A L A
Sbjct: 2140 QERNEEIEKLEFRV-----------------RELEQALLVSA------------------ 2164
Query: 287 KSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQL 346
+ + E+ H +A + +L+ ++ + I + EKE+T ++++ RE +
Sbjct: 2165 -DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL--EQFREELEN 2221
Query: 347 LNMPVVKGDFDLQIAKQDYYTARQELVL-NQLIKQ---------KASFELLQLSYEIELR 396
N V + L+I K++ T QEL N+L K K S + +
Sbjct: 2222 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2281
Query: 397 KHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLE 456
K I ++ E + +L++ L +QL++ TD V ++ N +D T + +
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNEL----IRDLETQIECLMSD 2337
Query: 457 GENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQ 516
E K+ L EV EKL+Q ++ + + +++A S +D++
Sbjct: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
Query: 517 GGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTL 560
Q+ +++E+T + ++ K+N LT L +K +R+++
Sbjct: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQ-LTQELFSLKRERESV 2440
Score = 44.7 bits (104), Expect = 3e-04
Identities = 112/578 (19%), Positives = 229/578 (39%), Gaps = 68/578 (11%)
Query: 57 ELEAFSILQKSGKPIL----EGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKL 112
E+ S + ++GKP E +D++ D T LE +E E L
Sbjct: 117 EVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPT------HLEMMESE----LAG 166
Query: 113 KNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDE 172
K +I+ N+ VT +E EA +KQ GI IT+++ LQ E
Sbjct: 167 KQHEIEELNRELEEMRVTYGTEGLQQLQEFEAA--IKQRDGI----ITQLTANLQQARRE 220
Query: 173 VTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVES 232
+ M F + F + E + STAA L K+Q H+
Sbjct: 221 KDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQ---- 274
Query: 233 SNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKW 292
Q L+ Q + D Q+ E+ ++++ LQ +++ K +S K I+
Sbjct: 275 ------QQLEEQDHLLEDYQKKKEDFTMQISFLQEKI--KVYEMEQDKKVENSNKEEIQE 326
Query: 293 AEESLHSLTSKAVDKEN-----------LDAKISSLTSEIMKLEKEVTQIKDRSLPAVVR 341
E + L +K +++E D + L +I++ +E+ +K + +
Sbjct: 327 KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 342 ENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDI 401
E + + G + ++ K+++ ++ E + Q ++Q+ +L QL E++ ++
Sbjct: 387 ERQSSEEIKQLMGTVE-ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELD-----EM 440
Query: 402 Y-RQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKD-------YSTHRLYQ 453
Y +Q+ + QEL + +M ++++ + + + I + + + L
Sbjct: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
Query: 454 VLEGENKKKE--------LFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNK 505
L+ N +KE + L+ E L + +S ++Q+ + Q + SK N+
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 506 DVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKL 565
L T+ +++ + + E K E+++ L + + +A ++
Sbjct: 561 AHKSL-STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
Query: 566 HQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED 603
++ER E+ L + E+LE + +I L+D
Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKD 657
Score = 36.6 bits (83), Expect = 0.068
Identities = 75/397 (18%), Positives = 160/397 (40%), Gaps = 81/397 (20%)
Query: 158 MITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLY 217
++ IS+ LQA +++ + + Q + V ++ E + ++E A +L
Sbjct: 1842 LMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFRQKQE---ATESLK 1894
Query: 218 TKKQFFQGIHEVVESSNEDNFQLLDIQTPSICD---NQEILEERRLE-----MARLQLAY 269
+++ + +HE ES + + + + D +++ L ER+++ + RL+
Sbjct: 1895 CQEELRERLHE--ESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
Query: 270 ICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT 329
+CA ++L L+A ++ + ++ ++A E L E KL KE
Sbjct: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ------QLLQETEKLMKEKL 2006
Query: 330 QIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQL 389
+++ + E V + L KQ + L++
Sbjct: 2007 EVQ-----------------------------------CQAEKVRDDLQKQ---VKALEI 2028
Query: 390 SYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTH 449
E ++ + ++ ++ + +L Q N L KQLE + Q I+ + D
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088
Query: 450 RLYQVLE--------GENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLS 501
+L Q L+ E++ +E+ +L+E +K + + L ++QL QE
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE-LLLSKEQLQRDIQE------ 2141
Query: 502 KRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQ 538
RN++++ L + + LL+S + F KVE +
Sbjct: 2142 -RNEEIEKLEFRVRELEQALLVS----ADTFQKVEDR 2173
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 52.0 bits (123), Expect = 2e-06
Identities = 130/621 (20%), Positives = 265/621 (42%), Gaps = 106/621 (17%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDE-VQT 108
+N E E +I+++ I+E E KT + D T DK L +L+++ VQ
Sbjct: 317 ENSNKEEIQEKETIIEELNTKIIE-----EEKKTLELKDKLTTA--DKLLGELQEQIVQK 369
Query: 109 LLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQ---GILNAMITKISNE 165
++KN+K++ N Q + + EE + K SQ I+ M + +
Sbjct: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429
Query: 166 LQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTA--------ALTLY 217
L+ L E+ ++ GQ +V + Q + ++++Q E+ AL Y
Sbjct: 430 LEQLRAELDEMY--------GQ---QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY 478
Query: 218 TKKQFFQGIHEVVESS-NEDNFQLLDIQTPSICDNQE---ILEE-----RRLEMARLQLA 268
+ + +++ + NE N +L D + +E ILEE R+LE +L+
Sbjct: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELS 538
Query: 269 YICAQHQLIHLKASNSSMKSSIKWAEESLHS-------LTSKAVDKENLD----AKISSL 317
+ ++ Q+ + + + +S + A +SL + + S + ++ L+ A++++
Sbjct: 539 F--SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 318 TSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQD------------- 364
++ LEKE + DR + E +L + + +L K+D
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656
Query: 365 -----YYTARQELVLNQLIK-------QKASFELLQLSYEIELRKHRDIYRQLEN-LVQE 411
+Y + + + N++ + +K + Q +E+ K +D+ + L N +E
Sbjct: 657 DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEE 716
Query: 412 LSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTH--G 469
++ L K++E+L Q+ + T++ + ++LE + K+KE L
Sbjct: 717 MTLQINELQKEIEIL-----RQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771
Query: 470 NLEEVAEKLKQNISLVQDQL----AVSAQEHSFFL-SKRNKDVDMLCDTLYQGGNQLLLS 524
LE LK ++D L VS +E FL S ++K D++++ ++L+
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK----DSVWEKEIEILIE 827
Query: 525 DQE-LTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYL 583
+ E L +Q ++ ++ K + + + + +Q +E Y LK +D L
Sbjct: 828 ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN---------YQELQEEYACLLKVKDDL 878
Query: 584 KDI--VENLETQSKIKAVSLE 602
+D + LE +SK+KA++ E
Sbjct: 879 EDSKNKQELEYKSKLKALNEE 899
Score = 48.9 bits (115), Expect = 1e-05
Identities = 98/488 (20%), Positives = 206/488 (42%), Gaps = 40/488 (8%)
Query: 99 LEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAM 158
L++LE E Q + + + L +++ + A + L + T+KL + + +
Sbjct: 1959 LQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL-------QETEKLMKEKLEVQCQ 2011
Query: 159 ITKISNELQ----ALTDEVTQLMMFFRHSNLGQGTNPLVFLSQF-SLEKYLSQEEQ--ST 211
K+ ++LQ AL +V + + F + T + Q +LEK L + +
Sbjct: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
Query: 212 AALTLYTKKQFFQGIHEVVESSNE--DNFQ-LLDIQTPSICDNQEILEERRLEMARLQLA 268
A+ ++ FQ + +E + FQ + + QT + L+E+ + + L L+
Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
Query: 269 YICAQHQLIHLKASNSSMKSSIKWAEESL------HSLTSKAVDKENLDAKISSLTSEIM 322
Q + ++ ++ E++L H +A + +L+ ++ + I
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAID 2191
Query: 323 KLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVL-NQLIKQ- 380
+ EKE+T ++++ RE + N V + L+I K++ T QEL N+L K
Sbjct: 2192 RKEKEITNLEEQL--EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDD 2249
Query: 381 --------KASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVS 432
K S + + K I ++ E + +L++ L +QL++ TD V
Sbjct: 2250 MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI 2309
Query: 433 QQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVS 492
++ N +D T + + E K+ L EV EKL+Q ++ + + +++
Sbjct: 2310 EEKNEL----IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN 2365
Query: 493 AQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILAD 552
A S +D++ Q+ +++E+T + ++ K+N LT L
Sbjct: 2366 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ-LTQELFS 2424
Query: 553 VKTKRKTL 560
+K +R+++
Sbjct: 2425 LKRERESV 2432
Score = 44.7 bits (104), Expect = 3e-04
Identities = 112/578 (19%), Positives = 229/578 (39%), Gaps = 68/578 (11%)
Query: 57 ELEAFSILQKSGKPIL----EGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKL 112
E+ S + ++GKP E +D++ D T LE +E E L
Sbjct: 117 EVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPT------HLEMMESE----LAG 166
Query: 113 KNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDE 172
K +I+ N+ VT +E EA +KQ GI IT+++ LQ E
Sbjct: 167 KQHEIEELNRELEEMRVTYGTEGLQQLQEFEAA--IKQRDGI----ITQLTANLQQARRE 220
Query: 173 VTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVES 232
+ M F + F + E + STAA L K+Q H+
Sbjct: 221 KDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQ---- 274
Query: 233 SNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKW 292
Q L+ Q + D Q+ E+ ++++ LQ +++ K +S K I+
Sbjct: 275 ------QQLEEQDHLLEDYQKKKEDFTMQISFLQEKI--KVYEMEQDKKVENSNKEEIQE 326
Query: 293 AEESLHSLTSKAVDKEN-----------LDAKISSLTSEIMKLEKEVTQIKDRSLPAVVR 341
E + L +K +++E D + L +I++ +E+ +K + +
Sbjct: 327 KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 342 ENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDI 401
E + + G + ++ K+++ ++ E + Q ++Q+ +L QL E++ ++
Sbjct: 387 ERQSSEEIKQLMGTVE-ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELD-----EM 440
Query: 402 Y-RQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKD-------YSTHRLYQ 453
Y +Q+ + QEL + +M ++++ + + + I + + + L
Sbjct: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
Query: 454 VLEGENKKKE--------LFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNK 505
L+ N +KE + L+ E L + +S ++Q+ + Q + SK N+
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 506 DVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKL 565
L T+ +++ + + E K E+++ L + + +A ++
Sbjct: 561 AHKSL-STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619
Query: 566 HQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED 603
++ER E+ L + E+LE + +I L+D
Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKD 657
Score = 37.4 bits (85), Expect = 0.040
Identities = 84/462 (18%), Positives = 183/462 (39%), Gaps = 81/462 (17%)
Query: 158 MITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLY 217
++ IS+ LQA +++ + + Q + V ++ E + ++E A +L
Sbjct: 1842 LMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFRQKQE---ATESLK 1894
Query: 218 TKKQFFQGIHEVVESSNEDNFQLLDIQTPSICD---NQEILEERRLE-----MARLQLAY 269
+++ + +HE ES + + + + D +++ L ER+++ + RL+
Sbjct: 1895 CQEELRERLHE--ESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952
Query: 270 ICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT 329
+CA ++L L+A ++ + ++ ++A E L E KL KE
Sbjct: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ------QLLQETEKLMKEKL 2006
Query: 330 QIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQL 389
+++ + E V + L KQ + L++
Sbjct: 2007 EVQ-----------------------------------CQAEKVRDDLQKQ---VKALEI 2028
Query: 390 SYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTH 449
E ++ + ++ ++ + +L Q N L KQLE + Q I+ + D
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088
Query: 450 RLYQVLE--------GENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLS 501
+L Q L+ E++ +E+ +L+E +K + + L ++QL QE
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE-LLLSKEQLQRDIQE------ 2141
Query: 502 KRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLA 561
RN++++ L + + LL+ D+ + F VE++ + D +++
Sbjct: 2142 -RNEEIEKLEFRVRELEQALLVEDR---KHFGAVEAKPELSLEVQLQAERDAIDRKEKEI 2197
Query: 562 NNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED 603
N Q+E +F + ++ + LE Q K L++
Sbjct: 2198 TNLEEQLE-QFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2238
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 51.2 bits (121), Expect = 3e-06
Identities = 112/602 (18%), Positives = 232/602 (38%), Gaps = 85/602 (14%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTL 109
+N + + E+ + GK I E L + L C+ K R E+E E+
Sbjct: 551 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGR-KVTEMEGQAKELSAK 609
Query: 110 L-------KLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKI 162
L K +N+K N+ A K + + + E++ +++Q + L + K+
Sbjct: 610 LALSIPAEKFENMKSSLSNEVNEKAK----KLVEMEREHEKSLSEIRQLKRELENVKAKL 665
Query: 163 SNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQF---SLEK-YLSQE--EQSTAALTL 216
+ ++ E + + + LG+ L +Q +EK YL + ++ LT+
Sbjct: 666 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 725
Query: 217 YTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLA-------- 268
K + +V E + + ++D + D + E++LEM +L L
Sbjct: 726 EMKNHYVP--LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDV 783
Query: 269 ----------------YICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDA 312
I + ++ LK S +K +E +H+LTS EN +
Sbjct: 784 SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTS-----ENTNL 838
Query: 313 KISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQL-LNMPVVKGDFDLQIAKQDYYTARQE 371
K + ++ +P E ++ LN + K + +L K+ + QE
Sbjct: 839 K---------------KMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQE 883
Query: 372 LV----LNQLIKQKASFELLQLSYE-IELRKHRDIYRQLENLVQELSQSNMMLYK----- 421
V N+++K+ Q+ E I L +H L ++++ SN +
Sbjct: 884 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 943
Query: 422 QLEMLT-DPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQ 480
Q E++T + Q +TI ++ + ++ E +++ T L++ + Q
Sbjct: 944 QEEIVTLHAEIKAQKKELDTI--QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQ 1001
Query: 481 NISLVQDQLAVSAQEHS------FFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHK 534
S+ ++++ + QE+ F L K +D +L + ++ L EL +Q
Sbjct: 1002 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD 1061
Query: 535 VESQLNKLNHLLTDILAD-VKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQ 593
+ + ++ ++ ++ + K + LA L Q + + L +ENL+ +
Sbjct: 1062 LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1121
Query: 594 SK 595
K
Sbjct: 1122 LK 1123
Score = 44.7 bits (104), Expect = 3e-04
Identities = 107/525 (20%), Positives = 196/525 (37%), Gaps = 91/525 (17%)
Query: 25 EDFDWLFEGVEDES-FLKWFCGNVNEQ---NVLSERELEA-FSILQKSGKPILEGAALDE 79
ED + F ++D++ LK N Q +S E EA S L +S + + + A
Sbjct: 878 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 937
Query: 80 ALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVT--------S 131
A ++ T + K +K D +Q +K+K I +C+ T S
Sbjct: 938 ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLS 997
Query: 132 HKSLRLNAKEEEATKKLKQSQGILNAMIT----------------KISNELQALTDEVTQ 175
++ + + EEE K +++ + + T ++ L TDE+ +
Sbjct: 998 EQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK 1057
Query: 176 LMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNE 235
+ +L Q + + + +E+ Q + A L K+ E ++ S
Sbjct: 1058 QL-----KDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLN 1112
Query: 236 DNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEE 295
+ L + S+ Q E+ + + +L HQL+ + SS+ AE
Sbjct: 1113 GTIENLKEELKSM---QRCYEKEQQTVTKL--------HQLLE-----NQKNSSVPLAE- 1155
Query: 296 SLHSLTSKAVDKE---------NLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQL 346
H +A +KE + + + E+ KL+ EV K RE L
Sbjct: 1156 --HLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1213
Query: 347 LNMPVVKGDFDLQIAKQDYYTA----RQELVLNQL-------IKQKASFELLQLSYEIEL 395
K D + QI+ + A + E V ++ I K ELL S E E+
Sbjct: 1214 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI 1273
Query: 396 RKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVL 455
+ ++ + + EL + KQ+E D +++ +N RL Q L
Sbjct: 1274 KDQKERCDKSLTTITELQRRIQESAKQIE-AKDNKITELLN----------DVERLKQAL 1322
Query: 456 EGENKKKELFLTHGN----LEEVAEKLKQNISLVQDQLAVSAQEH 496
G +L T GN ++ + L+ + ++ QLA + ++H
Sbjct: 1323 NG---LSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQH 1364
Score = 43.1 bits (100), Expect = 7e-04
Identities = 104/536 (19%), Positives = 220/536 (41%), Gaps = 81/536 (15%)
Query: 97 KELEKL----EDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQ 152
KELE + E Q LKL+N + +C+ +A L +E++ +++KQ +
Sbjct: 431 KELEAMRTFCESAKQDRLKLQNELAHKVAECKALA-------LECERVKEDSDEQIKQLE 483
Query: 153 GILNAMITKISNELQALTDEVTQLMMFFRH--SNLGQGTNPLVFLSQFSLEKYLSQEEQS 210
L + ++ + T + H S G + L + L K L + +
Sbjct: 484 DALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL-KDLKVKYEG 542
Query: 211 TAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTP-----SICDNQEILEERRLEMARL 265
+A + Q Q +VE D +L++ S+C+ + + R++
Sbjct: 543 ASAEVGKLRNQIKQN-EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEG 601
Query: 266 QLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLE 325
Q + A+ L +MKSS+ + + KA ++ + SEI +L+
Sbjct: 602 QAKELSAKLALSIPAEKFENMKSSLS------NEVNEKAKKLVEMEREHEKSLSEIRQLK 655
Query: 326 KEVTQIKDRSLPAV-------VRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVL-NQL 377
+E+ +K + V V+ + + + K +L + Q +++ L N+L
Sbjct: 656 RELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL 715
Query: 378 IKQKASFELLQL-SYEIELRKHRDIYRQLENLVQELSQ-----SNMMLYKQLEM----LT 427
+K++A +++ ++ + L+ D+ + + ++ +L++ + K+LEM L
Sbjct: 716 LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 775
Query: 428 DPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQD 487
+ S+S+ ++ T+ + E +KE+ N+ E LK+ +S ++
Sbjct: 776 NDSLSKDVSRLETV------------FVPPEKHEKEIIALKSNIVE----LKKQLSELKK 819
Query: 488 QLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLT 547
+ QE L+ N ++ + ++S+Q + + H+ ++ L
Sbjct: 820 KCGED-QEKIHALTSENTNL------------KKMMSNQYVPVKTHE------EVKMTLN 860
Query: 548 DILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED 603
D LA KT R+ L K + + +V + LK +EN + Q K + +SL +
Sbjct: 861 DTLA--KTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE 914
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 51.2 bits (121), Expect = 3e-06
Identities = 112/602 (18%), Positives = 232/602 (38%), Gaps = 85/602 (14%)
Query: 50 QNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTL 109
+N + + E+ + GK I E L + L C+ K R E+E E+
Sbjct: 564 RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGR-KVTEMEGQAKELSAK 622
Query: 110 L-------KLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKI 162
L K +N+K N+ A K + + + E++ +++Q + L + K+
Sbjct: 623 LALSIPAEKFENMKSSLSNEVNEKAK----KLVEMEREHEKSLSEIRQLKRELENVKAKL 678
Query: 163 SNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQF---SLEK-YLSQE--EQSTAALTL 216
+ ++ E + + + LG+ L +Q +EK YL + ++ LT+
Sbjct: 679 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Query: 217 YTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLA-------- 268
K + +V E + + ++D + D + E++LEM +L L
Sbjct: 739 EMKNHYVP--LKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDV 796
Query: 269 ----------------YICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDA 312
I + ++ LK S +K +E +H+LTS EN +
Sbjct: 797 SRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTS-----ENTNL 851
Query: 313 KISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQL-LNMPVVKGDFDLQIAKQDYYTARQE 371
K + ++ +P E ++ LN + K + +L K+ + QE
Sbjct: 852 K---------------KMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQE 896
Query: 372 LV----LNQLIKQKASFELLQLSYE-IELRKHRDIYRQLENLVQELSQSNMMLYK----- 421
V N+++K+ Q+ E I L +H L ++++ SN +
Sbjct: 897 FVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKG 956
Query: 422 QLEMLT-DPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQ 480
Q E++T + Q +TI ++ + ++ E +++ T L++ + Q
Sbjct: 957 QEEIVTLHAEIKAQKKELDTI--QECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQ 1014
Query: 481 NISLVQDQLAVSAQEHS------FFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHK 534
S+ ++++ + QE+ F L K +D +L + ++ L EL +Q
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKD 1074
Query: 535 VESQLNKLNHLLTDILAD-VKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQ 593
+ + ++ ++ ++ + K + LA L Q + + L +ENL+ +
Sbjct: 1075 LSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1134
Query: 594 SK 595
K
Sbjct: 1135 LK 1136
Score = 44.7 bits (104), Expect = 3e-04
Identities = 107/525 (20%), Positives = 196/525 (37%), Gaps = 91/525 (17%)
Query: 25 EDFDWLFEGVEDES-FLKWFCGNVNEQ---NVLSERELEA-FSILQKSGKPILEGAALDE 79
ED + F ++D++ LK N Q +S E EA S L +S + + + A
Sbjct: 891 EDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEIL 950
Query: 80 ALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVT--------S 131
A ++ T + K +K D +Q +K+K I +C+ T S
Sbjct: 951 ANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLS 1010
Query: 132 HKSLRLNAKEEEATKKLKQSQGILNAMIT----------------KISNELQALTDEVTQ 175
++ + + EEE K +++ + + T ++ L TDE+ +
Sbjct: 1011 EQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNK 1070
Query: 176 LMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNE 235
+ +L Q + + + +E+ Q + A L K+ E ++ S
Sbjct: 1071 QL-----KDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLN 1125
Query: 236 DNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEE 295
+ L + S+ Q E+ + + +L HQL+ + SS+ AE
Sbjct: 1126 GTIENLKEELKSM---QRCYEKEQQTVTKL--------HQLLE-----NQKNSSVPLAE- 1168
Query: 296 SLHSLTSKAVDKE---------NLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQL 346
H +A +KE + + + E+ KL+ EV K RE L
Sbjct: 1169 --HLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDL 1226
Query: 347 LNMPVVKGDFDLQIAKQDYYTA----RQELVLNQL-------IKQKASFELLQLSYEIEL 395
K D + QI+ + A + E V ++ I K ELL S E E+
Sbjct: 1227 SKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEI 1286
Query: 396 RKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVL 455
+ ++ + + EL + KQ+E D +++ +N RL Q L
Sbjct: 1287 KDQKERCDKSLTTITELQRRIQESAKQIE-AKDNKITELLN----------DVERLKQAL 1335
Query: 456 EGENKKKELFLTHGN----LEEVAEKLKQNISLVQDQLAVSAQEH 496
G +L T GN ++ + L+ + ++ QLA + ++H
Sbjct: 1336 NG---LSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQH 1377
Score = 43.1 bits (100), Expect = 7e-04
Identities = 104/536 (19%), Positives = 220/536 (41%), Gaps = 81/536 (15%)
Query: 97 KELEKL----EDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQ 152
KELE + E Q LKL+N + +C+ +A L +E++ +++KQ +
Sbjct: 444 KELEAMRTFCESAKQDRLKLQNELAHKVAECKALA-------LECERVKEDSDEQIKQLE 496
Query: 153 GILNAMITKISNELQALTDEVTQLMMFFRH--SNLGQGTNPLVFLSQFSLEKYLSQEEQS 210
L + ++ + T + H S G + L + L K L + +
Sbjct: 497 DALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQL-KDLKVKYEG 555
Query: 211 TAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTP-----SICDNQEILEERRLEMARL 265
+A + Q Q +VE D +L++ S+C+ + + R++
Sbjct: 556 ASAEVGKLRNQIKQN-EMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEG 614
Query: 266 QLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLE 325
Q + A+ L +MKSS+ + + KA ++ + SEI +L+
Sbjct: 615 QAKELSAKLALSIPAEKFENMKSSLS------NEVNEKAKKLVEMEREHEKSLSEIRQLK 668
Query: 326 KEVTQIKDRSLPAV-------VRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVL-NQL 377
+E+ +K + V V+ + + + K +L + Q +++ L N+L
Sbjct: 669 RELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKL 728
Query: 378 IKQKASFELLQL-SYEIELRKHRDIYRQLENLVQELSQ-----SNMMLYKQLEM----LT 427
+K++A +++ ++ + L+ D+ + + ++ +L++ + K+LEM L
Sbjct: 729 LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 788
Query: 428 DPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQD 487
+ S+S+ ++ T+ + E +KE+ N+ E LK+ +S ++
Sbjct: 789 NDSLSKDVSRLETV------------FVPPEKHEKEIIALKSNIVE----LKKQLSELKK 832
Query: 488 QLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLT 547
+ QE L+ N ++ + ++S+Q + + H+ ++ L
Sbjct: 833 KCGED-QEKIHALTSENTNL------------KKMMSNQYVPVKTHE------EVKMTLN 873
Query: 548 DILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVSLED 603
D LA KT R+ L K + + +V + LK +EN + Q K + +SL +
Sbjct: 874 DTLA--KTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE 927
>gi|149363642 coiled-coil domain containing 144A [Homo sapiens]
Length = 1427
Score = 51.2 bits (121), Expect = 3e-06
Identities = 109/525 (20%), Positives = 210/525 (40%), Gaps = 62/525 (11%)
Query: 99 LEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAM 158
L +L E++T+ +L +Q RN Q S + +++ T K K+ + M
Sbjct: 747 LRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARI---LQDQILTSKQKELEMARKKM 803
Query: 159 ITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYT 218
++IS+ Q D +F L + + L + ++ +Q +Q
Sbjct: 804 NSEISHRHQKEKD------LFHEDCMLQEE----IALLRLEIDTIKNQNKQK-------- 845
Query: 219 KKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIH 278
+K++F+ I V E + DN Q + I N+E L E L+ + QL + A++++++
Sbjct: 846 EKKYFEDIEAVKEKN--DNLQKI------IKLNEETLTETILQYSG-QLNNLTAENKILN 896
Query: 279 LKASNSSMKSS-IKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLP 337
+ N ++ ES + AV + L + + +E ++ D+
Sbjct: 897 SELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKV 956
Query: 338 AV--VRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLS----- 390
+ ++ ++L+ + + + + + R L LI ++ +L Q
Sbjct: 957 DMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKE 1016
Query: 391 ----YEIELRKHRDIYRQLENLVQELSQ---SNMMLYKQLEMLTDPSVSQQINPRNTIDT 443
Y+IE K + + E++ + LSQ NM+L +QL+ + SQ+ T T
Sbjct: 1017 TEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQE----KTSST 1072
Query: 444 KDYSTHRLYQVLEGENKKKELFLTHGNLEEVAE--KLKQNISLVQDQLAVSAQEHSFFLS 501
H + L+ E++K+ L L N E + E LK+ + DQ L+
Sbjct: 1073 IQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERM----DQCEKEKAGRKIDLT 1128
Query: 502 KRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLA 561
+ + V C L+ +L Q+ ++ Q L + +V + +
Sbjct: 1129 EAQETVPSRC--LHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYME 1186
Query: 562 NNKLHQMEREFYVYFLKDEDYLKDIVENLE----TQSKIKAVSLE 602
N L + + E++ L +E K+I E L T K AVS E
Sbjct: 1187 RNMLERGKAEWH-KLLIEERARKEIEEKLNEAILTLQKQAAVSHE 1230
Score = 34.7 bits (78), Expect = 0.26
Identities = 59/267 (22%), Positives = 107/267 (40%), Gaps = 51/267 (19%)
Query: 231 ESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQL--IHLKASNSSMKS 288
+ E +Q+ + QE +EER +++LQ + + QL H KA++ S
Sbjct: 1014 KKETEQMYQIEQSKLKKYIAKQESVEER---LSQLQSENMLLRQQLDDAHKKANSQEKTS 1070
Query: 289 SIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLN 348
S ++ HS +K + E+ + +I SL + +L E +K+R + + ++
Sbjct: 1071 ST--IQDQFHS-AAKNLQAES-EKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKID 1126
Query: 349 MPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENL 408
+ T QE V ++ + A E+LQL + K I +Q E L
Sbjct: 1127 L-----------------TEAQETVPSRCLHLDAENEVLQLQQTLFSMKA--IQKQCETL 1167
Query: 409 VQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTH 468
Q N KQ ++ K Y + + G+ + +L +
Sbjct: 1168 -----QKNKKQLKQ----------------EVVNLKSYMERNMLE--RGKAEWHKLLIEE 1204
Query: 469 GNLEEVAEKLKQNISLVQDQLAVSAQE 495
+E+ EKL + I +Q Q AVS ++
Sbjct: 1205 RARKEIEEKLNEAILTLQKQAAVSHEQ 1231
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 50.8 bits (120), Expect = 3e-06
Identities = 96/541 (17%), Positives = 211/541 (39%), Gaps = 49/541 (9%)
Query: 89 LKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKL 148
LK RL+++ EK+ + + +L K Q + + L S T+ N E+ +
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 149 KQSQGILN--AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQ 206
+ Q I N A++ K + L E L ++ + G L+Q + + Q
Sbjct: 520 DKDQKIQNLEALLQKSKENISLLEKEREDL-----YAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 207 EEQSTAALTLYTK----KQFFQGIHEVVESSNED----NFQLLDIQTPSICDNQEILEER 258
E+ + L + KQ + +H+ V+ ++L ++T S+ + L E
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET-SVNELNSQLNES 633
Query: 259 RLEMARLQLAYICAQHQLIHLKASNSSMKSSIK----WAEESLHS--------------L 300
+ ++++L + L+ +A+ ++ ++ ++ A+ +L +
Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
Query: 301 TSKAVDKE----NLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDF 356
T+K DK+ L++ + + + LE++ +++ + + + A L + K
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQ----IKKLEADSLEVKASKEQA 749
Query: 357 DLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSN 416
+ +Q EL +L KQ + + S ++L+K + ++ + + +
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 417 MMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAE 476
+L + E L+ + Q N I T ++ +E E EL L +V++
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKV--KMEKEALMTELSTVKDKLSKVSD 867
Query: 477 KLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVE 536
LK + + + Q+ + K L L L +EL + K +
Sbjct: 868 SLKNS----KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 537 SQLNKLNHLLTDILADVKTKRKTLANNKLHQMEREFYVYFLK-DEDYLKDIVENLETQSK 595
++L L + + + TL N+ + + + + LK + K +E L+ + K
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 596 I 596
I
Sbjct: 984 I 984
Score = 48.5 bits (114), Expect = 2e-05
Identities = 85/426 (19%), Positives = 174/426 (40%), Gaps = 44/426 (10%)
Query: 105 EVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEE-EATKKLKQSQGILNAMITKIS 163
E LK ++ + R+ L AS+ K K+E E + L+Q + + ++T S
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 164 NELQALTDE----------VTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQE-EQSTA 212
ELQ+L + + Q+ F T S++ E+ L + EQ
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194
Query: 213 ALTLYTKKQ--FFQGIH-EVVESSNEDNFQLLD---IQTPSICDNQEILEERRLEMAR-- 264
LT K+ Q + E+++ ++ +L +Q ++ DN + ER E +
Sbjct: 195 RLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 265 ---LQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEI 321
LQ Y ++ + L++ + + + L L S L K +LT +
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSV---NELTQKNQTLTENL 311
Query: 322 MKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLI--- 378
+K E++ T+++++ E+ N+ DL + + E L+++
Sbjct: 312 LKKEQDYTKLEEKHN----EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL 367
Query: 379 --KQKASFELLQLSYEIELRKH--RDIYRQLENLVQELSQSNMMLYKQLEMLTDP--SVS 432
K +A+ +L + E+E + + ++QL+ +E Q + L ++ L
Sbjct: 368 SEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 433 QQINPRN--TIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLA 490
+Q+ + + + S+ +L ++ E + +L L LEE ++ N + +Q QL
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKL---MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 484
Query: 491 VSAQEH 496
+ Q+H
Sbjct: 485 KTKQQH 490
Score = 48.1 bits (113), Expect = 2e-05
Identities = 103/479 (21%), Positives = 185/479 (38%), Gaps = 72/479 (15%)
Query: 111 KLKNLKIQRRNKCQLMASVTSHKSLR---LNAKEEEATKKLKQSQGILNAMITKISNELQ 167
K+ L IQ + K +L+ S + K+ + L + A L+ Q LN + T++
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Query: 168 ALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIH 227
L D+ H L ++ EKYLS E Q T L KK +
Sbjct: 696 KLQDKQEHCSQLESH------------LKEYK-EKYLSLE-QKTEELEGQIKKLEADSLE 741
Query: 228 EVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMK 287
V++S E Q L Q D LE R E+++ QL K SS +
Sbjct: 742 --VKASKEQALQDLQQQRQLNTD----LELRATELSK----------QLEMEKEIVSSTR 785
Query: 288 SSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLL 347
++ E+L S+ K +E +I+K + E + + + Q
Sbjct: 786 LDLQKKSEALESIKQKLTKQEE--------EKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 348 NMPVVKGDFDLQIAKQDYYTARQEL--VLNQLIKQKASFE---------LLQLSYEIELR 396
+ K + + + T + +L V + L K+ FE +L L +
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 397 KHRDIYRQLENLVQELSQSNMMLYK------QLEMLTDPSVSQQINPRNTIDTKDYSTHR 450
KH+ + Q+EN ++E + L K QL++ + Q I +NT+ + +
Sbjct: 898 KHQ-LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956
Query: 451 LYQVLE-----GENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNK 505
L + E KKK++ G L+ + + + +Q QL +AQE L+ +
Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE----LAAEKE 1012
Query: 506 DVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNK 564
+ +L + Y+ + ++L F+ ES+L L + + ++ L +N+
Sbjct: 1013 KISVLQNN-YEKSQETF---KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Score = 30.8 bits (68), Expect = 3.7
Identities = 51/218 (23%), Positives = 90/218 (41%), Gaps = 27/218 (12%)
Query: 358 LQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEI-ELRKHRDIYRQL-ENLVQELSQS 415
L+ A+ + + +Q + L +QKA+ QL+ EI +++ D R L E Q++++
Sbjct: 144 LEEAQTENFNIKQ---MKDLFEQKAA----QLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 416 NMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQV--------LEGENKKKELFLT 467
L K+ ++ D + ++ R I+ L QV LE E + ++L
Sbjct: 197 TEELNKEATVIQD--LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDE 254
Query: 468 HGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQE 527
L+ + IS ++ +LA QE + ++ + K L N+L +Q
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK--------LKSSVNELTQKNQT 306
Query: 528 LTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKL 565
LTE K E KL + K + TL L
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL 344
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 50.8 bits (120), Expect = 3e-06
Identities = 103/517 (19%), Positives = 215/517 (41%), Gaps = 65/517 (12%)
Query: 43 FCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTP---RLDDKEL 99
FC N ++ ++ + + K KP+L+ A ++ + T K K + +
Sbjct: 818 FCIQYNIRSFMNVKHWPWMKLFFKI-KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR 876
Query: 100 EKLEDEVQTLLKLKN-LKIQRRNKCQLMASVTSH------KSLRLNAKEEEATKKLKQSQ 152
++LE+++ TLLK KN L++Q + + + +A ++L AK +E T++ + +
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936
Query: 153 GILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTA 212
I NA +T +L+ DE ++L L L++ EK+ ++ +
Sbjct: 937 EI-NAELTAKKRKLE---DECSELKKDIDDLELT--------LAKVEKEKHATENKVKNL 984
Query: 213 ALTLYTKKQFFQGIHEVVESSNEDNFQLLD-IQTPSICDNQEILEERRLEMARLQLAYIC 271
+ + + + ++ E + Q LD +Q N + +LE L
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
Query: 272 AQHQLIH--LKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT 329
Q + + L+ + ++ +K A+ES+ + + +K+ LD K+ EI L+ ++
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN---EKQQLDEKLKKKEFEISNLQSKI- 1100
Query: 330 QIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQL 389
E+ Q L + + K +LQ AR E + ++ ++AS +
Sbjct: 1101 ------------EDEQALGIQLQKKIKELQ--------ARIEELEEEIEAERASRAKAE- 1139
Query: 390 SYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTID-TKDYST 448
++ D+ R+LE + + L ++ Q+EM Q R+ + T +
Sbjct: 1140 ------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 449 HRLYQVLEGENKKKELFLTHGNLEEVAEKL---KQNISLVQDQLAVSAQEHSFFLSKRNK 505
+ + EL NL+ V +KL K + + D LA + + +SK
Sbjct: 1194 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET----VSKAKG 1249
Query: 506 DVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKL 542
+++ +C TL ++L ++E + + +Q +L
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRL 1286
Score = 42.0 bits (97), Expect = 0.002
Identities = 108/561 (19%), Positives = 225/561 (40%), Gaps = 53/561 (9%)
Query: 76 ALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKI-QRRNKCQLMASVTSHKS 134
AL AL++ + D R +E ++ + E+Q L N ++ Q R K + A + +
Sbjct: 1334 ALAHALQSSR-HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 135 LRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLG------QG 188
K + + ++ +NA + Q L +EV LM+ +N +
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452
Query: 189 TNPLVFLSQFS-------LEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLL 241
N L+++ E SQ+E + L+ K ++ + +E+ +N L
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL- 1511
Query: 242 DIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLT 301
I D E + E + L+ + + L+A+ ++S++ E + +
Sbjct: 1512 ---QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
Query: 302 SKAVD-KENLDAKISSLTSEIMKLEK---EVTQIKDRSLPAVVRENAQLLNM-PVVKGDF 356
+ K +D KI+ EI +L++ + + +L A +R + + ++GD
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1628
Query: 357 DLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQL------ENLVQ 410
+ + ++ L + + Q+ + LR D+ QL NL+Q
Sbjct: 1629 NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQ 1688
Query: 411 -ELSQSNMMLYK--------QLEMLTDPSVSQQINPRNT--IDTKDYSTHRLYQVLEGEN 459
E+ + L + + E+L Q ++ +NT I+TK + Q+ +
Sbjct: 1689 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQM---QG 1745
Query: 460 KKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGN 519
+ +++ N EE A+K + +++ ++L Q+ S L + K+++ L
Sbjct: 1746 EMEDILQEARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNMEQTVKDL----- 1799
Query: 520 QLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKT--KRKTLANNKLHQMEREFYVYFL 577
QL L + E + Q+ KL + ++ +V++ KR A L + ER
Sbjct: 1800 QLRLDEAEQL-ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTY 1858
Query: 578 KDEDYLKDIVENLETQSKIKA 598
+ E+ K+I+ + K++A
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQA 1879
Score = 38.9 bits (89), Expect = 0.014
Identities = 121/586 (20%), Positives = 221/586 (37%), Gaps = 152/586 (25%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+K LED+ L LK + + +L+ +T+ + RL + E +++L + +
Sbjct: 1252 EKMCRTLEDQ------LSELKSKEEEQQRLINDLTAQRG-RLQTESGEFSRQLDEKE--- 1301
Query: 156 NAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFS------LEKYLSQEEQ 209
A+++++S QA T ++ +L + N L Q S L + +E++
Sbjct: 1302 -ALVSQLSRGKQAFTQQIEELKRQLEEEI--KAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 210 STAALTLYTKK-------------------------------QFFQGIHEVVES------ 232
S A L K Q Q E VE+
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418
Query: 233 ---------SNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASN 283
NE +LD++ + ++R + + C + L+AS
Sbjct: 1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA-ELEASQ 1477
Query: 284 SSMKS------SIKWA-EESLHSLTSKAVDKENLDAKISSLTS----------EIMKLEK 326
+S IK A EESL L + + +NL +IS LT E+ K++K
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 327 EVTQIKDRSLPAVVRENAQL-----------LNMPVVKGDFDLQIAKQDYYTARQELVLN 375
+V Q K A+ A L L + VK + D +IA++D ++
Sbjct: 1538 QVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE-------EID 1590
Query: 376 QLIKQKASF-ELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQ 434
QL + E +Q + + E+R D R + + +L++ + Q
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI----------------Q 1634
Query: 435 INPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQ 494
+N N + + R Y+ +G K ++ L + E LK+ +++V+ + +
Sbjct: 1635 LNHANRMAAE---ALRNYRNTQGILKDTQIHLDDALRSQ--EDLKEQLAMVERRANLLQA 1689
Query: 495 EHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVK 554
E ++ L TL Q +++QEL + +V+ L H L + K
Sbjct: 1690 E-----------IEELRATLEQTERSRKIAEQELLDASERVQ-----LLHTQNTSLINTK 1733
Query: 555 TKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVS 600
K +T + QM+ E ED L++ N E ++K KA++
Sbjct: 1734 KKLET----DISQMQGEM-------EDILQE-ARNAEEKAK-KAIT 1766
Score = 35.0 bits (79), Expect = 0.20
Identities = 70/304 (23%), Positives = 123/304 (40%), Gaps = 47/304 (15%)
Query: 75 AALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQ--RRNKCQLMASVTS- 131
AAL+EA + + + K R+ EL +++ EV + K+ +I +RN +++ S+ S
Sbjct: 1548 AALEEAEASLEHEEGKILRIQ-LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 132 --------HKSLRLNAKEE------------------EATKKLKQSQGILNAMITKISNE 165
+ ++RL K E EA + + +QGIL + +
Sbjct: 1607 LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDA 1666
Query: 166 LQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQS--TAALTLYTKKQFF 223
L++ D QL M R +NL Q L L Q E+S A L +
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERV 1719
Query: 224 QGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKA-- 281
Q +H S +L + + ++IL+E R + + A A LK
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 282 -SNSSMKSSIKWAEESLHSLTSKAVDKENLDAK-----ISSLTSEIMKLEKEVTQIKDRS 335
+++ ++ K E+++ L + + E L K I L + + +LE EV + R+
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 336 LPAV 339
AV
Sbjct: 1840 AEAV 1843
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 50.8 bits (120), Expect = 3e-06
Identities = 103/517 (19%), Positives = 215/517 (41%), Gaps = 65/517 (12%)
Query: 43 FCGNVNEQNVLSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTP---RLDDKEL 99
FC N ++ ++ + + K KP+L+ A ++ + T K K + +
Sbjct: 818 FCIQYNIRSFMNVKHWPWMKLFFKI-KPLLKSAETEKEMATMKEEFQKIKDELAKSEAKR 876
Query: 100 EKLEDEVQTLLKLKN-LKIQRRNKCQLMASVTSH------KSLRLNAKEEEATKKLKQSQ 152
++LE+++ TLLK KN L++Q + + + +A ++L AK +E T++ + +
Sbjct: 877 KELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 936
Query: 153 GILNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTA 212
I NA +T +L+ DE ++L L L++ EK+ ++ +
Sbjct: 937 EI-NAELTAKKRKLE---DECSELKKDIDDLELT--------LAKVEKEKHATENKVKNL 984
Query: 213 ALTLYTKKQFFQGIHEVVESSNEDNFQLLD-IQTPSICDNQEILEERRLEMARLQLAYIC 271
+ + + + ++ E + Q LD +Q N + +LE L
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
Query: 272 AQHQLIH--LKASNSSMKSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVT 329
Q + + L+ + ++ +K A+ES+ + + +K+ LD K+ EI L+ ++
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN---EKQQLDEKLKKKEFEISNLQSKI- 1100
Query: 330 QIKDRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQL 389
E+ Q L + + K +LQ AR E + ++ ++AS +
Sbjct: 1101 ------------EDEQALGIQLQKKIKELQ--------ARIEELEEEIEAERASRAKAE- 1139
Query: 390 SYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTID-TKDYST 448
++ D+ R+LE + + L ++ Q+EM Q R+ + T +
Sbjct: 1140 ------KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 449 HRLYQVLEGENKKKELFLTHGNLEEVAEKL---KQNISLVQDQLAVSAQEHSFFLSKRNK 505
+ + EL NL+ V +KL K + + D LA + + +SK
Sbjct: 1194 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVET----VSKAKG 1249
Query: 506 DVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKL 542
+++ +C TL ++L ++E + + +Q +L
Sbjct: 1250 NLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRL 1286
Score = 42.0 bits (97), Expect = 0.002
Identities = 108/561 (19%), Positives = 225/561 (40%), Gaps = 53/561 (9%)
Query: 76 ALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKI-QRRNKCQLMASVTSHKS 134
AL AL++ + D R +E ++ + E+Q L N ++ Q R K + A + +
Sbjct: 1334 ALAHALQSSR-HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 135 LRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVTQLMMFFRHSNLG------QG 188
K + + ++ +NA + Q L +EV LM+ +N +
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452
Query: 189 TNPLVFLSQFS-------LEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLL 241
N L+++ E SQ+E + L+ K ++ + +E+ +N L
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL- 1511
Query: 242 DIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLT 301
I D E + E + L+ + + L+A+ ++S++ E + +
Sbjct: 1512 ---QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
Query: 302 SKAVD-KENLDAKISSLTSEIMKLEK---EVTQIKDRSLPAVVRENAQLLNM-PVVKGDF 356
+ K +D KI+ EI +L++ + + +L A +R + + ++GD
Sbjct: 1569 LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1628
Query: 357 DLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQL------ENLVQ 410
+ + ++ L + + Q+ + LR D+ QL NL+Q
Sbjct: 1629 NEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQ 1688
Query: 411 -ELSQSNMMLYK--------QLEMLTDPSVSQQINPRNT--IDTKDYSTHRLYQVLEGEN 459
E+ + L + + E+L Q ++ +NT I+TK + Q+ +
Sbjct: 1689 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQM---QG 1745
Query: 460 KKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGN 519
+ +++ N EE A+K + +++ ++L Q+ S L + K+++ L
Sbjct: 1746 EMEDILQEARNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNMEQTVKDL----- 1799
Query: 520 QLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKT--KRKTLANNKLHQMEREFYVYFL 577
QL L + E + Q+ KL + ++ +V++ KR A L + ER
Sbjct: 1800 QLRLDEAEQL-ALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTY 1858
Query: 578 KDEDYLKDIVENLETQSKIKA 598
+ E+ K+I+ + K++A
Sbjct: 1859 QTEEDRKNILRLQDLVDKLQA 1879
Score = 38.9 bits (89), Expect = 0.014
Identities = 121/586 (20%), Positives = 221/586 (37%), Gaps = 152/586 (25%)
Query: 96 DKELEKLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGIL 155
+K LED+ L LK + + +L+ +T+ + RL + E +++L + +
Sbjct: 1252 EKMCRTLEDQ------LSELKSKEEEQQRLINDLTAQRG-RLQTESGEFSRQLDEKE--- 1301
Query: 156 NAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFS------LEKYLSQEEQ 209
A+++++S QA T ++ +L + N L Q S L + +E++
Sbjct: 1302 -ALVSQLSRGKQAFTQQIEELKRQLEEEI--KAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 210 STAALTLYTKK-------------------------------QFFQGIHEVVES------ 232
S A L K Q Q E VE+
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418
Query: 233 ---------SNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASN 283
NE +LD++ + ++R + + C + L+AS
Sbjct: 1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA-ELEASQ 1477
Query: 284 SSMKS------SIKWA-EESLHSLTSKAVDKENLDAKISSLTS----------EIMKLEK 326
+S IK A EESL L + + +NL +IS LT E+ K++K
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1537
Query: 327 EVTQIKDRSLPAVVRENAQL-----------LNMPVVKGDFDLQIAKQDYYTARQELVLN 375
+V Q K A+ A L L + VK + D +IA++D ++
Sbjct: 1538 QVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE-------EID 1590
Query: 376 QLIKQKASF-ELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQ 434
QL + E +Q + + E+R D R + + +L++ + Q
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI----------------Q 1634
Query: 435 INPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQ 494
+N N + + R Y+ +G K ++ L + E LK+ +++V+ + +
Sbjct: 1635 LNHANRMAAE---ALRNYRNTQGILKDTQIHLDDALRSQ--EDLKEQLAMVERRANLLQA 1689
Query: 495 EHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVK 554
E ++ L TL Q +++QEL + +V+ L H L + K
Sbjct: 1690 E-----------IEELRATLEQTERSRKIAEQELLDASERVQ-----LLHTQNTSLINTK 1733
Query: 555 TKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVENLETQSKIKAVS 600
K +T + QM+ E ED L++ N E ++K KA++
Sbjct: 1734 KKLET----DISQMQGEM-------EDILQE-ARNAEEKAK-KAIT 1766
Score = 35.0 bits (79), Expect = 0.20
Identities = 70/304 (23%), Positives = 123/304 (40%), Gaps = 47/304 (15%)
Query: 75 AALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQ--RRNKCQLMASVTS- 131
AAL+EA + + + K R+ EL +++ EV + K+ +I +RN +++ S+ S
Sbjct: 1548 AALEEAEASLEHEEGKILRIQ-LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 132 --------HKSLRLNAKEE------------------EATKKLKQSQGILNAMITKISNE 165
+ ++RL K E EA + + +QGIL + +
Sbjct: 1607 LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDA 1666
Query: 166 LQALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQS--TAALTLYTKKQFF 223
L++ D QL M R +NL Q L L Q E+S A L +
Sbjct: 1667 LRSQEDLKEQLAMVERRANLLQAEIE-------ELRATLEQTERSRKIAEQELLDASERV 1719
Query: 224 QGIHEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKA-- 281
Q +H S +L + + ++IL+E R + + A A LK
Sbjct: 1720 QLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQ 1779
Query: 282 -SNSSMKSSIKWAEESLHSLTSKAVDKENLDAK-----ISSLTSEIMKLEKEVTQIKDRS 335
+++ ++ K E+++ L + + E L K I L + + +LE EV + R+
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 336 LPAV 339
AV
Sbjct: 1840 AEAV 1843
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 50.4 bits (119), Expect = 5e-06
Identities = 101/537 (18%), Positives = 210/537 (39%), Gaps = 55/537 (10%)
Query: 70 PILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRR-NKCQLMAS 128
P+ + + +L+ + + + + KE+ + D ++ +++K K+ N + S
Sbjct: 132 PVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
Query: 129 VTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDEVT---QLMMFFRHSNL 185
K L E K+ ++ + +QAL DE+ L F+ +
Sbjct: 192 PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSS 251
Query: 186 GQGTNPLVF-LSQFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQ 244
+ P V L++ + ++ ++ E+ L L K E +E E Q L+ +
Sbjct: 252 SRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL------EEMELRIETQKQTLNAR 305
Query: 245 TPSICDNQEILEERRLEMA----------RLQLAYICAQH--QLIHLKASNSSM--KSSI 290
SI E+L+ + L RL A + H L+ K +SM +
Sbjct: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 291 KWAEESLHSLTSKAVDK--ENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLN 348
+ E + S +KA+ E D+KISS+ + LE+E+ +K + ++
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 349 MPVVK----------GDFDLQIAKQD----YYTARQELVLNQLIKQKASFELLQLSYEIE 394
M V + G +++++D + E + NQ K E+L+ S +
Sbjct: 426 MEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 485
Query: 395 LRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDY--STHRLY 452
++ + +++ L L + ML K+ + + D + + D KD R
Sbjct: 486 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 545
Query: 453 QVLEG--ENKKKELFLTHGNLEEVAEKLKQ-NISLVQDQLAVSAQEHSFFLSKRNKDVDM 509
VL+ EN +++L + + E++K A++ E + L+++ + ++
Sbjct: 546 NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA--LAEKERTIER 603
Query: 510 LCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLNHLLTDILADVKTKRKTLANNKLH 566
L + Q ++E E+ + L L ++ + D+ K +L + K H
Sbjct: 604 LKE-------QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEH 653
Score = 38.9 bits (89), Expect = 0.014
Identities = 91/546 (16%), Positives = 201/546 (36%), Gaps = 120/546 (21%)
Query: 101 KLEDEVQTLLKLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGI------ 154
+ D Q + LK + + ++ + LRL KE KK KQ Q +
Sbjct: 467 QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 526
Query: 155 ------------------LNAMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVFLS 196
+N + KI N + L D+ Q+ Q +
Sbjct: 527 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 586
Query: 197 QFSLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEILE 256
+LE+ L+++E++ + + E + + + +D + D +E +
Sbjct: 587 LTTLEEALAEKERT------------IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 634
Query: 257 ERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKEN------- 309
+ +++ + + + + L +S S +K E +L + + E+
Sbjct: 635 LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 694
Query: 310 --LDAKIS-SLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVV---KGDFDLQIAKQ 363
L+A+ S ++ I LE+E+T+ KD S A + L + V K D D +IA+
Sbjct: 695 AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAEL 754
Query: 364 DYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQL 423
+ Q+ Q L+ ++E +K + + L+ S+ L L
Sbjct: 755 E----------RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 804
Query: 424 EMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNIS 483
D +EE+ E L++++
Sbjct: 805 RKKDD-----------------------------------------RIEELEEALRESVQ 823
Query: 484 LVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKVESQLNKLN 543
+ ++ V AQE S ++ N + + +LL++ +++ ++ ++++L+
Sbjct: 824 ITAEREMVLAQEES---ARTNAEKQV---------EELLMAMEKVKQELESMKAKLSSTQ 871
Query: 544 HLLTD---ILADVKTKRKTLANNKLHQMEREFYVYFLKDEDYLKDIVE----NLETQSKI 596
L + L +++ +R+ L +M++E + + ++D ++E +TQ ++
Sbjct: 872 QSLAEKETHLTNLRAERRKHLEEVL-EMKQEALLAAISEKDANIALLELSSSKKKTQEEV 930
Query: 597 KAVSLE 602
A+ E
Sbjct: 931 AALKRE 936
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 50.1 bits (118), Expect = 6e-06
Identities = 123/554 (22%), Positives = 220/554 (39%), Gaps = 114/554 (20%)
Query: 98 ELEKLEDEVQTLL-KLKNLKIQRRNKCQLMASVTSHKSLRLNAKEEEATKKLKQSQGILN 156
ELEKL ++++ L K K L+I + + + T K +E EA K+ L
Sbjct: 81 ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTK------EELEAEKR------DLI 128
Query: 157 AMITKISNELQALTDEVTQLMMFFRHSNLGQGTNPLVF-------LSQFSLEKYLSQEEQ 209
++S EL+ LT++V +L + SN +G L +S EK L QE++
Sbjct: 129 RTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKE 188
Query: 210 STAALTLYTKKQFFQGIHEVVESSNEDNFQLLDIQTPSICDNQEI--LEER--------- 258
+ + + E++ E ++L+++ +E+ LEE+
Sbjct: 189 LLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNE 248
Query: 259 -----------RLEMARLQLAYICAQ-HQLI--HLKASN--------SSMKSS-IKWAEE 295
+L+ A+ Q A + + H + H+K SN S KS+ + A E
Sbjct: 249 HLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVE 308
Query: 296 SLHSLTSKAVD------------KENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVREN 343
LH L +A + +++ D + +I +LEKE+ D L A R+
Sbjct: 309 ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENAND-LLSATKRKG 367
Query: 344 AQLLN-------------MPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLS 390
A L +VK L Y + +L+L +L ++ + L ++
Sbjct: 368 AILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIV 427
Query: 391 YEIE-----LRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTD--------PSVSQQINP 437
E+E L++ R+ Y + + V LS K+++ L + SV ++ N
Sbjct: 428 KEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNR 487
Query: 438 RNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQLAVSAQEHS 497
R I KD S ++E E + + EEV+ + S V Q VS +
Sbjct: 488 RMEIQVKDLSQQIRVLLMELEEARGNHVIRD---EEVSSADISSSSEVISQHLVSYRN-- 542
Query: 498 FFLSKRNKDVDMLCDTLYQGGNQLLLSDQEL--TEQFHKVESQLNKLNHLLTDILADVKT 555
+ L Q +LL++ +EL T + + E+ +K+ L L T
Sbjct: 543 -------------IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK-LESALT 588
Query: 556 KRKTLANNKLHQME 569
+ + L ++ HQM+
Sbjct: 589 ELEQLRKSRQHQMQ 602
Score = 49.3 bits (116), Expect = 1e-05
Identities = 102/515 (19%), Positives = 220/515 (42%), Gaps = 87/515 (16%)
Query: 87 SDLKTPRLDDKELEKLEDEVQTLLKLKNLKIQRRN-------------KCQLMASVTSH- 132
S+ +T + ++EKLE E+ L K ++++R+ K QL H
Sbjct: 829 SETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHL 888
Query: 133 --KSLRLNAKEEEATKKLKQSQGILNAMITKISNEL---------QALTDEVTQLMMFFR 181
K L NA++E AT LKQ + + S++ + + D V+QL
Sbjct: 889 NTKELLKNAQKEIAT--LKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 182 HSN-----LGQGTNPLVFLSQF--SLEKYLSQEEQSTAALTLYTKKQFFQGIHEVVESSN 234
N L T+ + SLE+ L++E+Q T + +K + E E
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEV----RKNIEVRLKESAEFQT 1002
Query: 235 EDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWA- 293
+ +L++++ + QE+ +++R + ++ QL LK + SS+++ ++ A
Sbjct: 1003 QLEKKLMEVEK----EKQELQDDKRRAIESME-------QQLSELKKTLSSVQNEVQEAL 1051
Query: 294 EESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVK 353
+ + +L+++ + + + K E+E+ + + A+ Q+ M V+
Sbjct: 1052 QRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL-MLHAADVEALQAAKEQVSKMASVR 1110
Query: 354 GDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELS 413
+ K + +QL++ KAS+E + R +D + ++L
Sbjct: 1111 QHLEETTQKAE----------SQLLECKASWEERE-------RMLKDEVSKCVCRCEDLE 1153
Query: 414 QSNMMLYKQLEMLTD---PSVSQQI-NPRN-TIDTKDYSTHRLYQVLEGENKKKELFLTH 468
+ N +L+ Q+E L+D SV + + P N ++ + S ++ ++L ++KE+ T
Sbjct: 1154 KQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETR 1213
Query: 469 GNLEEVAE-KLKQNISLVQDQLAVSAQEHSFFLSKRNKDVDMLCDTLYQGG--------- 518
+ +V + +Q + L++ +L QE L+ + V + T+ Q
Sbjct: 1214 FEVAQVESLRYRQRVELLEREL----QELQDSLNAEREKVQVTAKTMAQHEELMKKTETM 1269
Query: 519 NQLLLSDQELTEQFHKVESQLNKLNHLLTDILADV 553
N ++ +++ L E+ ++E L ++ + + D+
Sbjct: 1270 NVVMETNKMLREEKERLEQDLQQMQAKVRKLELDI 1304
Score = 44.3 bits (103), Expect = 3e-04
Identities = 98/461 (21%), Positives = 178/461 (38%), Gaps = 59/461 (12%)
Query: 78 DEALK-TCKTSDL-KTPRLDDKELEKLEDEVQTLLK---------------------LKN 114
DE K C+ DL K RL ++EKL D+V +K L+
Sbjct: 1140 DEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEI 1199
Query: 115 LKIQRRNK--CQLMASVTSHKSLRLNAKEEEATKKLKQSQGILNAMITKISNELQALTDE 172
L+ RR K + V +SLR + E ++L++ Q LNA K+ + +
Sbjct: 1200 LRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQH 1259
Query: 173 VTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTL------------YTKK 220
+LM N+ TN ++ + LE+ L Q + L L K
Sbjct: 1260 -EELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS 1318
Query: 221 QFFQG----IHEVVESSNEDNFQLLDIQT-PSICDNQEILEERRLEMARLQLAYICAQHQ 275
Q + E V+ N L+ Q P + +++L E+ + R+Q
Sbjct: 1319 GMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL 1378
Query: 276 LIHLKASNSSMKSS---IKWAEESLHSL-TSKAVDKENLDAKISSLTSEIMKLEKEVTQI 331
+ SN+S+ ++ I+ +E L+ + T K +++LDAKI + ++ K +TQ+
Sbjct: 1379 KAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKV----KTITQV 1434
Query: 332 KDRSLPAVVR-ENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQLIKQKASFELLQLS 390
K + E + V++ Q+ + + QE + +L + E S
Sbjct: 1435 KKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE--MQELKETLNQAETKSKS 1492
Query: 391 YEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEML---TDPSVSQQINPRNTIDTKDYS 447
E ++ + + E + L + + L +L L +Q+ R I K+
Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
Query: 448 THRLYQVLEGENKKKELFLTHGNLEEVAEKLKQNISLVQDQ 488
T + ++ ++K L L + E+LKQ + Q
Sbjct: 1553 TRK--AIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQ 1591
Score = 43.5 bits (101), Expect = 6e-04
Identities = 97/484 (20%), Positives = 192/484 (39%), Gaps = 55/484 (11%)
Query: 77 LDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKLKNLKI--------QRRNKCQLMAS 128
L E + K + ++ +++LEKL+++V T L+ +N KI +R Q
Sbjct: 675 LQEIFENYKKEKAENEKIQNEQLEKLQEQV-TDLRSQNTKISTQLDFASKRYEMLQDNVE 733
Query: 129 VTSHKSLRLNAKEEEATKKLKQSQGILNAMITKI--SNELQALTDEVTQLMMFFRHSNLG 186
+ L+ + ++ T ++ + I+N M + +NE A+ + R NL
Sbjct: 734 GYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAE--------VRAENLK 785
Query: 187 QGTNPLVFLSQFSLEKYLSQEEQSTAALT-----LYTKKQFFQGIHEVVESSNEDNF--- 238
+ L E LSQ+ +S A L T Q QGI E E+ +
Sbjct: 786 KEKEMLKLS-----EVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
Query: 239 -QLLDIQTPSICDNQEILEERRLEMAR-LQLAYICAQHQLIHLKASNSSMKSSIKWAEES 296
+ L+ + + E E+R + R L + + + QL + + K +K A++
Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
Query: 297 LHSLTSKAVDKENLDAKISSLTSEIMKLEKEVTQIKDRSLPAVVRENAQLLNMPVVKGDF 356
+ +L N++ +++S +S+ + + L + +R+ + +N +K
Sbjct: 901 IATLKQHL---SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVND--LKERL 955
Query: 357 DLQIAKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSN 416
+ + Y A + L K+K E ++ + E+ L++ + QLE + E+ +
Sbjct: 956 KTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEK 1015
Query: 417 MMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLEEVAE 476
L Q + R I++ + L + L + + L + E
Sbjct: 1016 QEL--------------QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE 1061
Query: 477 KLKQNISLVQDQLAVSAQ-EHSFFLSKRNKDVDMLCDTLYQGGNQLLLSDQELTEQFHKV 535
+ + Q ++AV AQ ++ L DV+ L + +++ Q L E K
Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEAL-QAAKEQVSKMASVRQHLEETTQKA 1120
Query: 536 ESQL 539
ESQL
Sbjct: 1121 ESQL 1124
Score = 40.4 bits (93), Expect = 0.005
Identities = 76/408 (18%), Positives = 175/408 (42%), Gaps = 62/408 (15%)
Query: 78 DEALKTCKTSD--LKTPRLDDKELEKLEDEVQTL------LKLKNLKIQRRNKCQLMASV 129
+E +K +T + ++T ++ +E E+LE ++Q + L+L L +Q N +
Sbjct: 1260 EELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEAN------AE 1313
Query: 130 TSHKSLRLNAKE---EEATKKLK-QSQGILNAMITKISNE--------------LQALTD 171
S KS L A++ EE K+ K ++Q +++ + E +Q LT+
Sbjct: 1314 LSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTE 1373
Query: 172 EVTQLMMFFRHSNLGQGTNPLVF------LSQFSLEKYLSQEEQSTAALTLYTKKQFFQG 225
E+ +L SN N + L++ EK Q++ + + K +
Sbjct: 1374 EIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQ 1433
Query: 226 IHEV-------VESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIH 278
+ ++ E ++++ S D+QE + EM L+ A+ +
Sbjct: 1434 VKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQ-EMQELKETLNQAETKSKS 1492
Query: 279 LKASNSSMKSSIKWAEESLHSLTSKAVDKEN----LDAKISSLTSEIMKLEKEVTQIKDR 334
L++ +++ ++ E +L + V ++ L + T++ +L +++T+ +++
Sbjct: 1493 LESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
Query: 335 SLPAVVRENAQLLNMPVVKGDFDLQIAKQDYYTARQELVLNQ--------LIKQKASFEL 386
+ A+V +++ ++ VK Q+ K++ ++ L+Q + K+ +E
Sbjct: 1553 TRKAIVAAKSKIAHLAGVKD----QLTKENEELKQRNGALDQQKDELDVRITALKSQYEG 1608
Query: 387 LQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQ 434
E ELR+H++ + + + QE S +Q+ + T P+ ++
Sbjct: 1609 RISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGER 1656
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 50.1 bits (118), Expect = 6e-06
Identities = 98/463 (21%), Positives = 187/463 (40%), Gaps = 92/463 (19%)
Query: 53 LSERELEAFSILQKSGKPILEGAALDEALKTCKTSDLKTPRLDDKELEKLEDEVQTLLKL 112
L+E ++ A L+K + ++ G L E L T K + E KL DE +TLL+
Sbjct: 599 LTEGQIAANEALKKDLEGVISG--LQEYLGTIKGQATQA----QNECRKLRDEKETLLQR 652
Query: 113 KNLKIQRRNKCQLMASVTSHKSLRLN------AKEEEATKKLKQSQGILNAMITKISNEL 166
Q R++ +++A + L ++ E L+Q+QG L+A ++ L
Sbjct: 653 LTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARL 712
Query: 167 QALTDEVTQLMMFFRHSNLGQGTNPLVFLSQFSLEKYLSQEEQSTAALTLYTKKQFFQGI 226
E QL L + T L L Q +L+ L +E Q A K QF
Sbjct: 713 NLRDAEANQL-----KEELEKVTR-LTQLEQSALQAELEKERQ--ALKNALGKAQF---- 760
Query: 227 HEVVESSNEDNFQLLDIQTPSICDNQEILEERRLEMARLQLAYICAQHQLIHLKASNSSM 286
E ++N +L +L HL+ N+ +
Sbjct: 761 ---SEEKEQENSEL--------------------------------HAKLKHLQDDNNLL 785
Query: 287 KSSIKWAEESLHSLTSKAVDKENLDAKISSLTSEIMKLEKEV-----TQIKDRSLPAVVR 341
K +K + L+ + V E + A++ L ++ E+ + + +SL + +
Sbjct: 786 KQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQK 845
Query: 342 ENAQLLNMPVVKGDFDLQI----AKQDYYTARQELVLNQLIKQKASFELLQLSYEIELRK 397
+ +++L + D + Q+ +++ +++L Q ++A L+ + R+
Sbjct: 846 QFSEILARSKWERD-EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQ 904
Query: 398 HRDIYRQLENLVQELSQSNMMLYKQLEMLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEG 457
H +Q+EN + L Q N+ ++++ LTD + + + I L Q+ E
Sbjct: 905 HEARIQQMENEIHYL-QENLKSMEEIQGLTDLQLQEADEEKERI---------LAQLREL 954
Query: 458 ENKKK--------ELFLTHGNLEEVAEKLKQNISLVQDQLAVS 492
E KKK ++F L++ +KLK+ ++ D+LA +
Sbjct: 955 EKKKKLEDAKSQEQVF----GLDKELKKLKKAVA-TSDKLATA 992
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 49.7 bits (117), Expect = 8e-06
Identities = 83/371 (22%), Positives = 148/371 (39%), Gaps = 65/371 (17%)
Query: 252 QEILEERRLEMARLQLAYICAQHQLIHLKASNSSMKSSIKWAEESLHSLTSKAVDKEN-L 310
+++LEE E Q L L S K I++ E LH++ K+ D E L
Sbjct: 8 KQVLEESAFEEMERDF-----QGVLHELSGDKSLEKFRIEY--ERLHAVMKKSYDNEKRL 60
Query: 311 DAKISSLTSEIM-KLEKEVTQIK----DRSLPAVVRENAQLLNMPVVKGDFDLQIAKQDY 365
AK L +EI+ K T +K D++ A +++ + V Q AK+
Sbjct: 61 MAKCRELNAEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETI 120
Query: 366 YTARQELV-LNQLIKQKASFELLQLSYEIELRKHRDIYRQLENLVQELSQSNMMLYKQLE 424
++E+V L +L++Q + + Q S RD+ R E + +E Q + K E
Sbjct: 121 LALKEEIVNLTKLVEQGSGLSMDQHS------NIRDLLRFKEEVTKERDQLLSEVVKLRE 174
Query: 425 MLTDPSVSQQINPRNTIDTKDYSTHRLYQVLEGENKKKELFLTHGNLE------------ 472
L + QQ R+ + + + ++ + +N+ F LE
Sbjct: 175 SLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDS 234
Query: 473 ---------EVAEKLKQNISLVQDQLAV-------SAQEHSFF------LSKRNKDVDML 510
+ +K K+ + ++ QL +A+E F L + N+ ++
Sbjct: 235 RQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLV 294
Query: 511 CDTLYQGGNQLLLSDQELTEQFHKVESQLNKLN----------HLLTDILADVKTKRKTL 560
C+ L Q Q L + E+ H++ + KLN H D A+V+ ++TL
Sbjct: 295 CEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKETL 354
Query: 561 ANNKLHQMERE 571
N++ +ERE
Sbjct: 355 -KNQIVGLERE 364
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.348
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,453,244
Number of Sequences: 37866
Number of extensions: 807866
Number of successful extensions: 3411
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 378
Number of HSP's that attempted gapping in prelim test: 2889
Number of HSP's gapped (non-prelim): 778
length of query: 603
length of database: 18,247,518
effective HSP length: 108
effective length of query: 495
effective length of database: 14,157,990
effective search space: 7008205050
effective search space used: 7008205050
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.