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Search of human proteins with 56118210
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|56118210 neurotrophic tyrosine kinase, receptor, type 1
isoform 3 [Homo sapiens]
(760 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 1550 0.0
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 1471 0.0
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 1465 0.0
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 741 0.0
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 731 0.0
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 707 0.0
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 697 0.0
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 285 8e-77
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo... 273 4e-73
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 251 2e-66
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo... 245 1e-64
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 244 3e-64
gi|62420886 discoidin domain receptor family, member 2 precursor... 244 3e-64
gi|62420884 discoidin domain receptor family, member 2 precursor... 244 3e-64
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 238 2e-62
gi|38327632 discoidin domain receptor family, member 1 isoform b... 238 2e-62
gi|83977450 discoidin domain receptor family, member 1 isoform a... 238 2e-62
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 237 3e-62
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 237 3e-62
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 237 3e-62
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo... 235 1e-61
gi|83977452 discoidin domain receptor family, member 1 isoform c... 231 2e-60
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 230 3e-60
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 227 3e-59
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 226 8e-59
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 226 8e-59
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 224 2e-58
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 224 2e-58
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 224 2e-58
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 224 2e-58
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 1550 bits (4014), Expect = 0.0
Identities = 760/760 (100%), Positives = 760/760 (100%)
Query: 1 MKEAALICLAPSVPPILTVKSWDTMQLRAARSRCTNLLAASYIENQQHLQHLELRDLRGL 60
MKEAALICLAPSVPPILTVKSWDTMQLRAARSRCTNLLAASYIENQQHLQHLELRDLRGL
Sbjct: 1 MKEAALICLAPSVPPILTVKSWDTMQLRAARSRCTNLLAASYIENQQHLQHLELRDLRGL 60
Query: 61 GELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPL 120
GELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPL
Sbjct: 61 GELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPL 120
Query: 121 HCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDD 180
HCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDD
Sbjct: 121 HCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDD 180
Query: 181 VLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAEND 240
VLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAEND
Sbjct: 181 VLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAEND 240
Query: 241 VGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFT 300
VGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFT
Sbjct: 241 VGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFT 300
Query: 301 EFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDP 360
EFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDP
Sbjct: 301 EFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDP 360
Query: 361 IPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL 420
IPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL
Sbjct: 361 IPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVL 420
Query: 421 APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWEL 480
APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWEL
Sbjct: 421 APEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWEL 480
Query: 481 GEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFF 540
GEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFF
Sbjct: 481 GEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFF 540
Query: 541 GVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAA 600
GVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAA
Sbjct: 541 GVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAA 600
Query: 601 GMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPP 660
GMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPP
Sbjct: 601 GMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPP 660
Query: 661 ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEV 720
ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEV
Sbjct: 661 ESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEV 720
Query: 721 YAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760
YAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Sbjct: 721 YAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 1471 bits (3809), Expect = 0.0
Identities = 720/723 (99%), Positives = 720/723 (99%)
Query: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
L YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL
Sbjct: 68 LTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 127
Query: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 157
ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP
Sbjct: 128 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 187
Query: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL
Sbjct: 188 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 247
Query: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 277
GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG
Sbjct: 248 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 307
Query: 278 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 337
QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF
Sbjct: 308 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 367
Query: 338 GQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLS 397
GQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLS
Sbjct: 368 GQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLS 427
Query: 398 TLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIEN 457
TLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIEN
Sbjct: 428 TLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIEN 487
Query: 458 PQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 517
PQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
Sbjct: 488 PQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 547
Query: 518 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 577
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG
Sbjct: 548 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 607
Query: 578 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 637
GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
Sbjct: 608 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 667
Query: 638 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 697
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN
Sbjct: 668 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 727
Query: 698 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 757
TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD
Sbjct: 728 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 787
Query: 758 VLG 760
VLG
Sbjct: 788 VLG 790
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 1465 bits (3792), Expect = 0.0
Identities = 720/729 (98%), Positives = 720/729 (98%), Gaps = 6/729 (0%)
Query: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
L YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL
Sbjct: 68 LTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 127
Query: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 157
ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP
Sbjct: 128 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 187
Query: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL
Sbjct: 188 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 247
Query: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 277
GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG
Sbjct: 248 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 307
Query: 278 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 337
QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF
Sbjct: 308 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 367
Query: 338 GQASASIMAAFMDNPFEFNPEDPIP------DTNSTSGDPVEKKDETPFGVSVAVGLAVF 391
GQASASIMAAFMDNPFEFNPEDPIP DTNSTSGDPVEKKDETPFGVSVAVGLAVF
Sbjct: 368 GQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVF 427
Query: 392 ACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 451
ACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ
Sbjct: 428 ACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 487
Query: 452 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK
Sbjct: 488 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 547
Query: 512 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD 571
EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD
Sbjct: 548 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD 607
Query: 572 AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG 631
AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG
Sbjct: 608 AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG 667
Query: 632 DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP 691
DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP
Sbjct: 668 DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP 727
Query: 692 WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA 751
WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA
Sbjct: 728 WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA 787
Query: 752 PPVYLDVLG 760
PPVYLDVLG
Sbjct: 788 PPVYLDVLG 796
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 741 bits (1913), Expect = 0.0
Identities = 397/749 (53%), Positives = 500/749 (66%), Gaps = 29/749 (3%)
Query: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
+ + +IEN + L L D+ L+ LTI SGLR + P AF P L +NLS N L
Sbjct: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
Query: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQGPL 153
+LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q PL
Sbjct: 140 TTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPL 199
Query: 154 AHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SATVMK 210
M + C +P + V N +V GD+ ++ C G L WI+T L+ T +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
Query: 211 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH-HW 269
+ ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH 319
Query: 270 CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNY 329
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NNGNY
Sbjct: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNNGNY 376
Query: 330 TLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVSVAV 386
TL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS+AV
Sbjct: 377 TLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
Query: 387 GLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSPTE- 444
GLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S +
Sbjct: 437 GLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDA 496
Query: 445 GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVFLAE 492
G + + G +IENPQYF D V HIKRRDIVLK ELGEGAFGKVFLAE
Sbjct: 497 GPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAE 556
Query: 493 CHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMV 552
C+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL+MV
Sbjct: 557 CYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMV 616
Query: 553 FEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 611
FEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +ASQ+A+GMVYLA HFV
Sbjct: 617 FEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFV 676
Query: 612 HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTE 671
HRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYRVGG TMLPIRWMPPESI+YRKFTTE
Sbjct: 677 HRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTE 736
Query: 672 SDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQRE 731
SDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR CP EVY +M GCWQRE
Sbjct: 737 SDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQRE 796
Query: 732 PQQRHSIKDVHARLQALAQAPPVYLDVLG 760
PQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 797 PQQRLNIKEIYKILHALGKATPIYLDILG 825
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 731 bits (1888), Expect = 0.0
Identities = 397/763 (52%), Positives = 500/763 (65%), Gaps = 43/763 (5%)
Query: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
+ + +IEN + L L D+ L+ LTI SGLR + P AF P L +NLS N L
Sbjct: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
Query: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQGPL 153
+LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q PL
Sbjct: 140 TTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPL 199
Query: 154 AHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SATVMK 210
M + C +P + V N +V GD+ ++ C G L WI+T L+ T +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
Query: 211 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH-HW 269
+ ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH 319
Query: 270 CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNY 329
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NNGNY
Sbjct: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNNGNY 376
Query: 330 TLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVSVAV 386
TL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS+AV
Sbjct: 377 TLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
Query: 387 GLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSPTE- 444
GLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S +
Sbjct: 437 GLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDA 496
Query: 445 GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIVLKWELGEGAFGKVFLAE 492
G + + G +IENPQYF D V HIKRRDIVLK ELGEGAFGKVFLAE
Sbjct: 497 GPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAE 556
Query: 493 CHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMV 552
C+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+HIV+F+GVC +G PL+MV
Sbjct: 557 CYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMV 616
Query: 553 FEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 611
FEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +ASQ+A+GMVYLA HFV
Sbjct: 617 FEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFV 676
Query: 612 HRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR--------------VGGRTMLPIRW 657
HRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYR VGG TMLPIRW
Sbjct: 677 HRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRW 736
Query: 658 MPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACP 717
MPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR CP
Sbjct: 737 MPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCP 796
Query: 718 PEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760
EVY +M GCWQREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 797 KEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 707 bits (1824), Expect = 0.0
Identities = 387/758 (51%), Positives = 494/758 (65%), Gaps = 46/758 (6%)
Query: 42 YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101
+I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N + N L SLS
Sbjct: 72 FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
Query: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157
K + L L EL+L GNP CSC + W++ +E Q L C + PLA++
Sbjct: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESSKNIPLANLQ 190
Query: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
+CG+P+ + PN +V+ G + L C V G + W + L S SL
Sbjct: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
Query: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276
+T N++SD + K ++C AEN VG + SV + V F P L + HHWCIPF+V
Sbjct: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
Query: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336
G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG+YTL+A N
Sbjct: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
Query: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETPF-GVSVAV 386
+G+ I A FM D+ N D I + T+ GD + +E P V+
Sbjct: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
Query: 387 G---LAVFACLFLSTL-------LLVLNKCGRRNKFGINRPA-VLAPEDGLAMSLHFMTL 435
G L+V+A + ++++ +L L K R +KFG+ PA V++ +D A LH ++
Sbjct: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISN 486
Query: 436 GGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACVHHIKRRDIVLKWELGE 482
G ++ S +EG + + +IENPQYF D V HIKR +IVLK ELGE
Sbjct: 487 GSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGE 546
Query: 483 GAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGV 542
GAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAELLT LQH+HIV+F+GV
Sbjct: 547 GAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGV 606
Query: 543 CTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGM 602
C EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L Q+L +A Q+AAGM
Sbjct: 607 CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTELTQSQMLHIAQQIAAGM 664
Query: 603 VYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPES 662
VYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYRVGG TMLPIRWMPPES
Sbjct: 665 VYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPES 724
Query: 663 ILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYA 722
I+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQGR L+RPR CP EVY
Sbjct: 725 IMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYE 784
Query: 723 IMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760
+M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 785 LMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 697 bits (1799), Expect = 0.0
Identities = 385/774 (49%), Positives = 493/774 (63%), Gaps = 62/774 (8%)
Query: 42 YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101
+I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N + N L SLS
Sbjct: 72 FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
Query: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157
K + L L EL+L GNP CSC + W++ +E Q L C + PLA++
Sbjct: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESSKNIPLANLQ 190
Query: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
+CG+P+ + PN +V+ G + L C V G + W + L S SL
Sbjct: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
Query: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276
+T N++SD + K ++C AEN VG + SV + V F P L + HHWCIPF+V
Sbjct: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
Query: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336
G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG+YTL+A N
Sbjct: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
Query: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETPF-GVSVAV 386
+G+ I A FM D+ N D I + T+ GD + +E P V+
Sbjct: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
Query: 387 G---LAVFACLFLSTL-------LLVLNKCGRRNKFG-----------------INRPAV 419
G L+V+A + ++++ +L L K R +KFG + +V
Sbjct: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV 486
Query: 420 LAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACV 466
++ +D A LH ++ G ++ S +EG + + +IENPQYF D V
Sbjct: 487 ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFV 546
Query: 467 HHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE 526
HIKR +IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAE
Sbjct: 547 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAE 606
Query: 527 LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPL 586
LLT LQH+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L
Sbjct: 607 LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTEL 664
Query: 587 GLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR 646
Q+L +A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYR
Sbjct: 665 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYR 724
Query: 647 VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ 706
VGG TMLPIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQ
Sbjct: 725 VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 784
Query: 707 GRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760
GR L+RPR CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 785 GRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 285 bits (730), Expect = 8e-77
Identities = 143/290 (49%), Positives = 186/290 (64%), Gaps = 10/290 (3%)
Query: 471 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLT 529
R +I ++GEGAFG+VF A LLP + +VAVK LKE AS + DFQREA L+
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
Query: 530 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---------DAKLLAGGED 580
+ +IV+ GVC G+P+ ++FEYM +GDLN FLRS P D + A
Sbjct: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
Query: 581 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 640
P PL + L +A QVAAGM YL+ FVHRDLATRNCLVG+ +VVKI DFG+SR+IY
Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
Query: 641 STDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 700
S DYY+ +PIRWMPPESI Y ++TTESDVW++GVVLWEIF+YG QP+Y +++ E
Sbjct: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
Query: 701 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 750
I + G L P CP E+Y +MR CW + P R S +H L+ + +
Sbjct: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861
Score = 35.0 bits (79), Expect = 0.26
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 168 VQVPNASVD--VGDDVLLRCQVEGRGLEQAGW----ILTEL-EQSATVMKSGGLPSLGLT 220
+ P +VD V + C VE + W IL +L + ++ ++G L LT
Sbjct: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQL----LT 85
Query: 221 LANVTSDLNRKNVTCWAENDVGRAEVS---VQVNVSF-----PASVQLHTAVEMHHWCIP 272
+ +V D + C A N VG A S +QV + P +V++ +E +P
Sbjct: 86 ILSV-EDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKI---IEGLKAVLP 141
Query: 273 FSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLL 332
+ G P PS+ W+ S L E S I + G LR++ + G Y +
Sbjct: 142 CTTMGNPKPSVSWIKGDSPLRENSRI----------AVLESGSLRIHNVQKEDAGQYRCV 191
Query: 333 AANPFGQASASIM 345
A N G A + ++
Sbjct: 192 AKNSLGTAYSKVV 204
Score = 33.9 bits (76), Expect = 0.58
Identities = 43/201 (21%), Positives = 80/201 (39%), Gaps = 26/201 (12%)
Query: 160 SCGVPTLKVQVP------NASVDVGDDVLLRCQVEGRGLEQAGWILTE--LEQSATVMKS 211
SCG +K++ N + G +L C G WI + L +++ +
Sbjct: 111 SCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV- 169
Query: 212 GGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-----EVSVQVNVSFPASVQLHTAVEM 266
L S L + NV + + C A+N +G A ++ V+V + + H
Sbjct: 170 --LESGSLRIHNVQKE-DAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
Query: 267 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 326
+ + G P P++ W+ NG+ ++ S ++ + + V L+L
Sbjct: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGS------IQESVKDRVIDSRLQL---FITKP 277
Query: 327 GNYTLLAANPFGQASASIMAA 347
G YT +A N G+ ++ AA
Sbjct: 278 GLYTCIATNKHGEKFSTAKAA 298
>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
c precursor [Homo sapiens]
Length = 612
Score = 273 bits (698), Expect = 4e-73
Identities = 170/441 (38%), Positives = 239/441 (54%), Gaps = 20/441 (4%)
Query: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
+ + +IEN + L L D+ L+ LTI SGLR + P AF P L +NLS N L
Sbjct: 80 ITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRL 139
Query: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQGPL 153
+LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q PL
Sbjct: 140 TTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPL 199
Query: 154 AHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SATVMK 210
M + C +P + V N +V GD+ ++ C G L WI+T L+ T +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLN 259
Query: 211 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH-HW 269
+ ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEH 319
Query: 270 CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNY 329
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NNGNY
Sbjct: 320 CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEG---EISEGCLLFNKPTHYNNGNY 376
Query: 330 TLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPV---EKKDETPFGVSVAV 386
TL+A NP G A+ +I F+ PF + ++ I + P+ K +E FGVS+AV
Sbjct: 377 TLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAV 436
Query: 387 GLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAMSLHFMTLGGSSLSPTE- 444
GLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A LH + G ++ S +
Sbjct: 437 GLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDA 496
Query: 445 GKGSGLQG----HIIENPQYF 461
G + + G +IENPQYF
Sbjct: 497 GPDTVVIGMTRIPVIENPQYF 517
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 251 bits (641), Expect = 2e-66
Identities = 128/273 (46%), Positives = 177/273 (64%), Gaps = 6/273 (2%)
Query: 479 ELGEGAFGKVFLAECHNLLPEQDK-MLVAVKALKEASESAR-QDFQREAELLTMLQHQHI 536
ELGE AFGK++ H LP D LVA+K LK+ + + +FQ+EA L+ L H +I
Sbjct: 478 ELGECAFGKIYKG--HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNI 535
Query: 537 VRFFGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAV 594
V G T+ +P+ M+FEY+ GDL+ FL RS D + + L G L +
Sbjct: 536 VCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
Query: 595 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 654
A Q+AAGM YL+ FVH+DLA RN L+G+ L VKI D G+SR+IYS DYYRV +++LP
Sbjct: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLP 655
Query: 655 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 714
IRWMPPE+I+Y KF+++SD+WSFGVVLWEIF++G QP+Y SN E I+ + + + L
Sbjct: 656 IRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSE 715
Query: 715 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 747
CPP +Y++M CW P +R KD+H RL++
Sbjct: 716 DCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS 748
>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
e precursor [Homo sapiens]
Length = 537
Score = 245 bits (625), Expect = 1e-64
Identities = 162/451 (35%), Positives = 240/451 (53%), Gaps = 36/451 (7%)
Query: 42 YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101
+I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N + N L SLS
Sbjct: 72 FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
Query: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157
K + L L EL+L GNP CSC + W++ +E Q L C + PLA++
Sbjct: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESSKNIPLANLQ 190
Query: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
+CG+P+ + PN +V+ G + L C V G + W + L S SL
Sbjct: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
Query: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276
+T N++SD + K ++C AEN VG + SV + V F P L + HHWCIPF+V
Sbjct: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
Query: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336
G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG+YTL+A N
Sbjct: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
Query: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETP-FGVSVAV 386
+G+ I A FM D+ N D I + T+ GD + +E P V+
Sbjct: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
Query: 387 G---LAVFACLFLST-------LLLVLNKCGRRNKFGINRPA-VLAPEDGLAMSLHFMTL 435
G L+V+A + +++ ++L L K R +KFG+ PA V++ +D A LH ++
Sbjct: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISN 486
Query: 436 GGSSLSPTEGKGSGL-----QGHIIENPQYF 461
G ++ S +EG + + +IENPQYF
Sbjct: 487 GSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 517
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 244 bits (622), Expect = 3e-64
Identities = 124/291 (42%), Positives = 178/291 (61%), Gaps = 11/291 (3%)
Query: 457 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
NP+YFS A V+ + R I + ELG+G+FG V+ ++ ++ + VA+K +
Sbjct: 977 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN 1036
Query: 512 EA-SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570
EA S R +F EA ++ H+VR GV ++G+P L++ E M GDL +LRS P
Sbjct: 1037 EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 1096
Query: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
+ + + P L +++ +A ++A GM YL FVHRDLA RNC+V + VKI
Sbjct: 1097 EME-----NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 1151
Query: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
GDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 1152 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 1211
Query: 691 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 741
P+ LSN + + + +G L++P CP ++ +MR CWQ P+ R S ++
Sbjct: 1212 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 244 bits (622), Expect = 3e-64
Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%)
Query: 463 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 511
D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 512 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570
+A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
+ DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI
Sbjct: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726
Query: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 689
DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ +
Sbjct: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786
Query: 690 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742
QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H
Sbjct: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846
Query: 743 ARL 745
L
Sbjct: 847 LLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 244 bits (622), Expect = 3e-64
Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%)
Query: 463 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 511
D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 512 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570
+A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
+ DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI
Sbjct: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726
Query: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 689
DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ +
Sbjct: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786
Query: 690 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742
QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H
Sbjct: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846
Query: 743 ARL 745
L
Sbjct: 847 LLL 849
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 238 bits (607), Expect = 2e-62
Identities = 119/271 (43%), Positives = 169/271 (62%), Gaps = 2/271 (0%)
Query: 479 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTMLQHQHIV 537
ELGE FGKV+ P + VA+K LK+ +E R++F+ EA L LQH ++V
Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
Query: 538 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVAS 596
GV T+ +PL M+F Y HGDL+ FL P + + + +D L + + +
Sbjct: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
Query: 597 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 656
Q+AAGM YL+ H VH+DLATRN LV L VKI D G+ R++Y+ DYY++ G ++LPIR
Sbjct: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
Query: 657 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 716
WM PE+I+Y KF+ +SD+WS+GVVLWE+F+YG QP+ SN + ++ I + L P C
Sbjct: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
Query: 717 PPEVYAIMRGCWQREPQQRHSIKDVHARLQA 747
P VYA+M CW P +R KD+H+RL+A
Sbjct: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRA 748
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 471 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 518
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
Query: 519 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 578
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
Query: 579 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 634
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749
Query: 635 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 693
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809
Query: 694 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 471 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 518
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 666
Query: 519 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 578
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 667 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 726
Query: 579 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 634
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 727 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 786
Query: 635 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 693
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 787 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 846
Query: 694 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 847 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 902
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 237 bits (605), Expect = 3e-62
Identities = 127/296 (42%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 457 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
NP+YFS + ++ + R I + ELG+G+FG V+ L ++ VA+K +
Sbjct: 957 NPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN 1016
Query: 512 E-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570
E AS +F +EA ++ + H+VR GV ++G+P L++ E M GDL LRS P
Sbjct: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
Query: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
+A+ G P P LG+++ +A ++A GM YLA FVHRDLA RNC+V Q VKI
Sbjct: 1077 EAENNPG----LPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKI 1131
Query: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
GDFGM+RD+Y TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 1132 GDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQ 1191
Query: 691 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 746
P+ LSN + + + G LE CP ++ +M CWQ P+ R S + +Q
Sbjct: 1192 PYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 237 bits (604), Expect = 3e-62
Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)
Query: 457 NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 506
NP+Y S + V + R I L ELG+G+FG V+ +++ + + VA
Sbjct: 984 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1043
Query: 507 VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 565
VK + E AS R +F EA ++ H+VR GV ++G+P L+V E M HGDL +L
Sbjct: 1044 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1103
Query: 566 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 625
RS P+A+ G P L +++ +A+++A GM YL FVHRDLA RNC+V
Sbjct: 1104 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
Query: 626 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 685
VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SD+WSFGVVLWEI
Sbjct: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
Query: 686 TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 741
+ +QP+ LSN + + + G L++P CP V +MR CWQ P+ R + ++
Sbjct: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1274
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 237 bits (604), Expect = 3e-62
Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)
Query: 457 NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 506
NP+Y S + V + R I L ELG+G+FG V+ +++ + + VA
Sbjct: 996 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1055
Query: 507 VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 565
VK + E AS R +F EA ++ H+VR GV ++G+P L+V E M HGDL +L
Sbjct: 1056 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1115
Query: 566 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 625
RS P+A+ G P L +++ +A+++A GM YL FVHRDLA RNC+V
Sbjct: 1116 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1170
Query: 626 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 685
VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SD+WSFGVVLWEI
Sbjct: 1171 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1230
Query: 686 TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 741
+ +QP+ LSN + + + G L++P CP V +MR CWQ P+ R + ++
Sbjct: 1231 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1286
>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
d precursor [Homo sapiens]
Length = 553
Score = 235 bits (600), Expect = 1e-61
Identities = 160/467 (34%), Positives = 239/467 (51%), Gaps = 52/467 (11%)
Query: 42 YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101
+I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N + N L SLS
Sbjct: 72 FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
Query: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157
K + L L EL+L GNP CSC + W++ +E Q L C + PLA++
Sbjct: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESSKNIPLANLQ 190
Query: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
+CG+P+ + PN +V+ G + L C V G + W + L S SL
Sbjct: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
Query: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276
+T N++SD + K ++C AEN VG + SV + V F P L + HHWCIPF+V
Sbjct: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
Query: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336
G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG+YTL+A N
Sbjct: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
Query: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETP-FGVSVAV 386
+G+ I A FM D+ N D I + T+ GD + +E P V+
Sbjct: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
Query: 387 G---LAVFACLFLST-------LLLVLNKCGRRNKF-----------------GINRPAV 419
G L+V+A + +++ ++L L K R +KF G+ +V
Sbjct: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV 486
Query: 420 LAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 461
++ +D A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 487 ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 533
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 231 bits (589), Expect = 2e-60
Identities = 134/302 (44%), Positives = 185/302 (61%), Gaps = 30/302 (9%)
Query: 471 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESA- 517
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++A
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAS 666
Query: 518 -----RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 572
R DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H +
Sbjct: 667 FSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 726
Query: 573 KLLAGGE---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV 628
K G A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +
Sbjct: 727 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 786
Query: 629 KIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 688
KI DFGMSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+
Sbjct: 787 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 846
Query: 689 K-QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD 740
+ QP+ QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR
Sbjct: 847 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 906
Query: 741 VH 742
+H
Sbjct: 907 LH 908
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 230 bits (587), Expect = 3e-60
Identities = 122/290 (42%), Positives = 166/290 (57%), Gaps = 12/290 (4%)
Query: 469 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-SESARQDFQREAEL 527
+ R++I L LG GAFG+V+ + + + + VAVK L E SE DF EA +
Sbjct: 1111 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 1170
Query: 528 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 587
++ HQ+IVR GV + P ++ E M GDL FLR P P L
Sbjct: 1171 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPSSLA 1222
Query: 588 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDY 644
+ LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY Y
Sbjct: 1223 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1282
Query: 645 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 704
YR GG MLP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ SN E ++ +
Sbjct: 1283 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1342
Query: 705 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV 754
T G ++ P+ CP VY IM CWQ +P+ R + + R++ Q P V
Sbjct: 1343 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV 1392
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 227 bits (579), Expect = 3e-59
Identities = 174/587 (29%), Positives = 270/587 (45%), Gaps = 50/587 (8%)
Query: 174 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 227
SV+V D RC AG I E + V+ LP L A VT D
Sbjct: 470 SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
Query: 228 LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 282
+ N TC A N +++V V ++F + T + H + G P P
Sbjct: 524 -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
Query: 283 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 342
++W +L+ T L P + ++G L ++ ++G YT +A N
Sbjct: 583 IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
Query: 343 SIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLV 402
+D P +P+ + G P K G+SV +A ++ +L +
Sbjct: 636 EAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA-----YIIAVLGL 682
Query: 403 LNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQY 460
+ C +R K +P PE S+ E + L +
Sbjct: 683 MFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 742
Query: 461 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 520
S + H R + LG+ FG+VFLA+ L + LV VK+L+ E + D
Sbjct: 743 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 802
Query: 521 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGE 579
F+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S D KL +
Sbjct: 803 FRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS--- 859
Query: 580 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 639
PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+ G+S+D+
Sbjct: 860 ----QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
Query: 640 YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 699
Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+ P ++ E
Sbjct: 916 YNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
Query: 700 AIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745
+ + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 975 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 341 SAS 343
+S
Sbjct: 210 CSS 212
Score = 30.8 bits (68), Expect = 4.9
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)
Query: 219 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 271
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
Query: 272 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 331
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
Query: 332 LAANPFGQASASIMAAFMD 350
+++ P G A +D
Sbjct: 482 MSSTPAGSIEAQARVQVLD 500
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 226 bits (575), Expect = 8e-59
Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)
Query: 219 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 273
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 555 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 613
Query: 274 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 333
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 614 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 666
Query: 334 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 393
N +D P +P+ + G P K G+SV +A
Sbjct: 667 GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 714
Query: 394 LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 451
++ +L ++ C +R K +P PE S+ E + L
Sbjct: 715 -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 773
Query: 452 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 774 SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 833
Query: 512 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 570
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S
Sbjct: 834 SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 893
Query: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 894 DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 946
Query: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+
Sbjct: 947 SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
Query: 691 PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745
P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 341 SAS 343
+S
Sbjct: 210 CSS 212
Score = 30.0 bits (66), Expect = 8.3
Identities = 32/146 (21%), Positives = 56/146 (38%), Gaps = 22/146 (15%)
Query: 219 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 271
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
Query: 272 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 331
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
Query: 332 LAANPFGQASASIMAAFMDNPFEFNP 357
+++ P G A ++ +F P
Sbjct: 482 MSSTPAGSIEAQARVQVLEK-LKFTP 506
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 226 bits (575), Expect = 8e-59
Identities = 161/536 (30%), Positives = 254/536 (47%), Gaps = 38/536 (7%)
Query: 219 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 273
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 425 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 483
Query: 274 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 333
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 484 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 536
Query: 334 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 393
N +D P +P+ + G P K G+SV +A
Sbjct: 537 GNSCNIKHTEAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA---- 584
Query: 394 LFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 451
++ +L ++ C +R K +P PE S+ E + L
Sbjct: 585 -YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLG 643
Query: 452 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 644 SGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQ 703
Query: 512 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGP 570
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S
Sbjct: 704 SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSK 763
Query: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 764 DEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKV 816
Query: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+
Sbjct: 817 SALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 875
Query: 691 PWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745
P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 876 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 931
Score = 40.0 bits (92), Expect = 0.008
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 341 SAS 343
+S
Sbjct: 210 CSS 212
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 466 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 524
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
Query: 525 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 584
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 613
Query: 585 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 641
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
Query: 642 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 701
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
Query: 702 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 759
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 791
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 466 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 524
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 441 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 500
Query: 525 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 584
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 501 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 552
Query: 585 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 641
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 553 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 612
Query: 642 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 701
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 613 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 672
Query: 702 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 759
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 673 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 730
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 224 bits (571), Expect = 2e-58
Identities = 186/621 (29%), Positives = 276/621 (44%), Gaps = 60/621 (9%)
Query: 174 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGL----PSLGLTLANVTSDLN 229
+V G+ V RC G W L + + + GG+ L + +V +
Sbjct: 161 AVPAGNTVKFRCPAAGNPTPTIRW-LKDGQAFHGENRIGGIRLRHQHWSLVMESVVPS-D 218
Query: 230 RKNVTCWAENDVGRAEVSVQVNV------------SFPASVQLHTAVEMHHWCIPFSVDG 277
R TC EN VG + ++V PA+ ++ C +S D
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS-DA 277
Query: 278 QPAPSLRWL----FNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 333
QP ++WL NGS F + + L+ A + L L + + G YT LA
Sbjct: 278 QP--HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 334 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 393
N G + S + P D T+ P + + S ++ LAV
Sbjct: 336 GNSIGLSYQSAWLTVL----------PEEDPTWTAAAPEARYTDIILYASGSLALAVL-- 383
Query: 394 LFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGH 453
L L+ L GR + PA + ++ F GSS + G++
Sbjct: 384 LLLAGLYRGQALHGRHPR----PPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLS 439
Query: 454 IIENPQYFSDAC--------VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML- 504
P + + R +VL LGEG FG+V AE + P +
Sbjct: 440 S-SGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 498
Query: 505 -VAVKALKE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDL 561
VAVK LK+ AS+ D E E++ ++ +H++I+ GVCT+ PL ++ E G+L
Sbjct: 499 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 558
Query: 562 NRFLRSH---GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR 618
FLR+ GPD L G + GPL L++ A QVA GM YL +HRDLA R
Sbjct: 559 REFLRARRPPGPD--LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 616
Query: 619 NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG 678
N LV + V+KI DFG++R ++ DYY+ LP++WM PE++ R +T +SDVWSFG
Sbjct: 617 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 676
Query: 679 VVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI 738
++LWEIFT G P+ + E + +G ++RP CPPE+Y +MR CW P QR +
Sbjct: 677 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 739 KD-VHARLQALAQAPPVYLDV 758
K V A + L YLD+
Sbjct: 737 KQLVEALDKVLLAVSEEYLDL 757
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 224 bits (571), Expect = 2e-58
Identities = 186/621 (29%), Positives = 276/621 (44%), Gaps = 60/621 (9%)
Query: 174 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGL----PSLGLTLANVTSDLN 229
+V G+ V RC G W L + + + GG+ L + +V +
Sbjct: 161 AVPAGNTVKFRCPAAGNPTPTIRW-LKDGQAFHGENRIGGIRLRHQHWSLVMESVVPS-D 218
Query: 230 RKNVTCWAENDVGRAEVSVQVNV------------SFPASVQLHTAVEMHHWCIPFSVDG 277
R TC EN VG + ++V PA+ ++ C +S D
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS-DA 277
Query: 278 QPAPSLRWL----FNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 333
QP ++WL NGS F + + L+ A + L L + + G YT LA
Sbjct: 278 QP--HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 334 ANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFAC 393
N G + S + P D T+ P + + S ++ LAV
Sbjct: 336 GNSIGLSYQSAWLTVL----------PEEDPTWTAAAPEARYTDIILYASGSLALAVL-- 383
Query: 394 LFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGH 453
L L+ L GR + PA + ++ F GSS + G++
Sbjct: 384 LLLAGLYRGQALHGRHPR----PPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLS 439
Query: 454 IIENPQYFSDAC--------VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML- 504
P + + R +VL LGEG FG+V AE + P +
Sbjct: 440 S-SGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQAS 498
Query: 505 -VAVKALKE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEYMRHGDL 561
VAVK LK+ AS+ D E E++ ++ +H++I+ GVCT+ PL ++ E G+L
Sbjct: 499 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNL 558
Query: 562 NRFLRSH---GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR 618
FLR+ GPD L G + GPL L++ A QVA GM YL +HRDLA R
Sbjct: 559 REFLRARRPPGPD--LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAAR 616
Query: 619 NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG 678
N LV + V+KI DFG++R ++ DYY+ LP++WM PE++ R +T +SDVWSFG
Sbjct: 617 NVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFG 676
Query: 679 VVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI 738
++LWEIFT G P+ + E + +G ++RP CPPE+Y +MR CW P QR +
Sbjct: 677 ILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF 736
Query: 739 KD-VHARLQALAQAPPVYLDV 758
K V A + L YLD+
Sbjct: 737 KQLVEALDKVLLAVSEEYLDL 757
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,645,742
Number of Sequences: 37866
Number of extensions: 1424217
Number of successful extensions: 6687
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 588
Number of HSP's successfully gapped in prelim test: 386
Number of HSP's that attempted gapping in prelim test: 3626
Number of HSP's gapped (non-prelim): 2042
length of query: 760
length of database: 18,247,518
effective HSP length: 110
effective length of query: 650
effective length of database: 14,082,258
effective search space: 9153467700
effective search space used: 9153467700
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.